National Library of Energy BETA

Sample records for drugs transportation fares

  1. Automating journey fare calculation for transport for London

    E-Print Network [OSTI]

    Maciejewski, Joshua J. (Joshua John)

    2008-01-01

    This thesis develops a method to automate journey fare calculation for Transport for London. Today, fares for every possible origin-destination station pair within the London Underground are prepared manually based on the ...

  2. Using Smart Card Fare Payment Data To Analyze Multi-Modal Public Transport Journeys in London

    E-Print Network [OSTI]

    Seaborn, Catherine

    This paper contributes to the emerging literature on the application of smart card fare payment data to public transportation planning. The research objective is to identify and assess complete, multimodal journeys using ...

  3. Assessing the impact of recent fare policy changes on public transport demand in London

    E-Print Network [OSTI]

    Jain, Nihit

    2011-01-01

    Public transit agencies across the world have been moving towards electronic ticketing technology and to take advantage of the greater flexibility, have made changes in fare structure. Over the last decade, Transport for ...

  4. Drug transport in brain via the cerebrospinal fluid

    E-Print Network [OSTI]

    Pardridge, William M

    2011-01-01

    diffusion. Drug transport into cerebrospinal fluid vs. brainDrug transport from blood to interstitial fluid (ISF) isDrug transport in brain via the cerebrospinal fluid William

  5. RM methods for multiple fare structure environments

    E-Print Network [OSTI]

    Kayser, Matthew R. (Matthew Russell)

    2008-01-01

    The rapid growth of Low Cost Carriers (LCC) and their simplified fare structures has created "semi-restricted" fare structures where lower classes are undifferentiated except for price, while higher fare classes are still ...

  6. The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

    E-Print Network [OSTI]

    Shugarts, Sarah; Benet, Leslie Z.

    2009-01-01

    A, Benet LZ. Effects of drug transporters on volume of4. Mizuno N, Sugiyama Y. Drug transporters: their role andand development of new drugs. Drug Metab. Pharmacokinet.

  7. Intermodal passenger flows on London's public transport network : automated inference of full passenger journeys using fare-transaction and vehicle-location data

    E-Print Network [OSTI]

    Gordon, Jason B. (Jason Benjamin)

    2012-01-01

    Urban public transport providers have historically planned and managed their networks and services with limited knowledge of their customers' travel patterns. While ticket gates and bus fareboxes yield counts of passenger ...

  8. THE DARK SIDE OF SECURITY BY OBSCURITY and Cloning MiFare Classic Rail and Building Passes, Anywhere, Anytime

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    , Anywhere, Anytime Nicolas T. Courtois University College London, Computer Science, Gower street, WC1E 6BT, London, UK Keywords: Access control, RFID, contactless smart cards, MiFare Classic, London Oyster card- wide and in public transportation. For more than 10 years the specification of these cards was kept

  9. Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2007-01-01

    Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

  10. Mechanical loading impacts intramuscular drug transport : impact on local drug delivery

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2008-01-01

    Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue ...

  11. Lothian Buses operate an exact fare system. If you are paying the driver (single fares or day tickets), please

    E-Print Network [OSTI]

    Adult and Young Student Ridacards offer unlimited travel on most Lothian Buses for 1 week, 4 weeks ­ any distance ­ Adult £1 NIGHT BUSES £2 flat fare for all-night travel (£1 when showing your valid's Buildings Moray House/Pleasance New College Old College Pollock Halls Royal Infirmary Western General NC KB

  12. SUPPLEMENTARY METHODS AND TABLES Drug transport from the blood into the lung tissue

    E-Print Network [OSTI]

    Kirschner, Denise

    1 SUPPLEMENTARY METHODS AND TABLES Drug transport from the blood into the lung tissue To study that enters the grid representing lung parenchyma via vascular sources, and diffuses among micro Once TNF inhibitors penetrate from blood into the lung tissue, they can bind TNF and thus block TNF

  13. A study of open payment fare systems : system design, fare engine algorithm and GTFS extension

    E-Print Network [OSTI]

    Wang, Yin, S.M. Massachusetts Institute of Technology

    2014-01-01

    This thesis describes the design and implementation of the key parts of an open payment system that supports mobile phone ticketing for the Long Island Railroad (LIRR), a part of the New York Metropolitan Transportation ...

  14. Drug disposition and targeting: Transport across the blood-brain barrier

    E-Print Network [OSTI]

    Rochat, Bertrand; Audus, Kenneth L.

    1999-01-01

    the BBB. Neutral amino-acid carriers have proven to be capable of transporting many amino acids, drugs and endogenous compounds with similar stuctures. Leucine, cysteine, serine, alanine, phenylalanine, L-dopa, L-tryptophan, the alkylating agent... the carriers for opioids at the BBB have not been resolved. The possibility obviously exists, however, for the design and development of opioid peptide therapeutics that target BBB carriers and achieve improve brain delivery (Thomas et al., 1997). The last...

  15. FaRe: a Mathematica package for tensor reduction of Feynman integrals

    E-Print Network [OSTI]

    Fiorentin, Michele Re

    2015-01-01

    We present FaRe, a package for Mathematica that implements the decomposition of a generic tensor Feynman integral, with arbitrary loop number, into scalar integrals in higher dimension. In order for FaRe to work, the package FeynCalc is needed, so that the tensor structure of the different contributions is preserved and the obtained scalar integrals are grouped accordingly. FaRe can prove particularly useful when it is preferable to handle Feynman integrals with free Lorentz indices and tensor reduction of high-order integrals is needed. This can then be achieved with several powerful existing tools.

  16. Rail transit OD matrix estimation and journey time reliability metrics using automated fare data

    E-Print Network [OSTI]

    Chan, Joanne, S.M. Massachusetts Institute of Technology

    2007-01-01

    The availability of automatic fare collection (AFC) data greatly enhances a transit planner's ability to understand and characterize passenger travel demands which have traditionally been estimated by manual surveys handed ...

  17. Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines

    SciTech Connect (OSTI)

    Brandon, Esther F.A.; Bosch, Tessa M.; Deenen, Maarten J.; Levink, Rianne; Wal, Everdina van der; Meerveld, Joyce B.M. van; Bijl, Monique; Beijnen, Jos H. |; Schellens, Jan H.M. |; Meijerman, Irma . E-mail: I.Meijerman@pharm.uu.nl

    2006-02-15

    Human cell lines are often used for in vitro biotransformation and transport studies of drugs. In vivo, genetic polymorphisms have been identified in drug-metabolizing enzymes and ABC-drug transporters leading to altered enzyme activity, or a change in the inducibility of these enzymes. These genetic polymorphisms could also influence the outcome of studies using human cell lines. Therefore, the aim of our study was to pharmacogenotype four cell lines frequently used in drug metabolism and transport studies, HepG2, IGROV-1, CaCo-2 and LS180, for genetic polymorphisms in biotransformation enzymes and drug transporters. The results indicate that, despite the presence of some genetic polymorphisms, no real effects influencing the activity of metabolizing enzymes or drug transporters in the investigated cell lines are expected. However, this characterization will be an aid in the interpretation of the results of biotransformation and transport studies using these in vitro cell models.

  18. Biogenic emissions from Citrus species in California Silvano Fares a,b,*, Drew R. Gentner c

    E-Print Network [OSTI]

    Goldstein, Allen

    Biogenic emissions from Citrus species in California Silvano Fares a,b,*, Drew R. Gentner c , Jeong May 2011 Accepted 26 May 2011 Keywords: BVOC emissions OVOC Terpene Basal emission rate Citrus a b such as the Central Valley of California. Moreover, the BVOC emissions from Citrus species have not been characterized

  19. Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport

    E-Print Network [OSTI]

    Tang, Hua, 1972-

    2002-01-01

    Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

  20. Estimating fare and expenditure elasticities of demand for air travel in the U.S. domestic market 

    E-Print Network [OSTI]

    Alwaked, Ahmad Abdelrahman Fahed

    2007-04-25

    This study estimates the demand for domestic air travel services in the United States in order to calculate the fare and expenditure elasticities of demand. We segmented the market according to number of operating airlines, ...

  1. Prediction of multi-drug resistance transporters using a novel sequence analysis method [version 2; referees: 2 approved

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    McDermott, Jason E.; Bruillard, Paul; Overall, Christopher C.; Gosink, Luke; Lindemann, Stephen R.

    2015-03-09

    There are many examples of groups of proteins that have similar function, but the determinants of functional specificity may be hidden by lack of sequencesimilarity, or by large groups of similar sequences with different functions. Transporters are one such protein group in that the general function, transport, can be easily inferred from the sequence, but the substrate specificity can be impossible to predict from sequence with current methods. In this paper we describe a linguistic-based approach to identify functional patterns from groups of unaligned protein sequences and its application to predict multi-drug resistance transporters (MDRs) from bacteria. We first showmore »that our method can recreate known patterns from PROSITE for several motifs from unaligned sequences. We then show that the method, MDRpred, can predict MDRs with greater accuracy and positive predictive value than a collection of currently available family-based models from the Pfam database. Finally, we apply MDRpred to a large collection of protein sequences from an environmental microbiome study to make novel predictions about drug resistance in a potential environmental reservoir.« less

  2. Algebra (Informatica) 9 gennaio 2003 Con pi di 18 punti si pu fare l'orale o accettare il voto dello scritto (30 e lode per chi

    E-Print Network [OSTI]

    Catenacci, Roberto

    Algebra (Informatica) ­ 9 gennaio 2003 Con più di 18 punti si può fare l'orale o accettare il voto

  3. Unaffordable fare : the cost of public transportation for low-income commuters working at three airports

    E-Print Network [OSTI]

    Nadeau, Carey Anne

    2015-01-01

    For airport employers, making sure the many low-income people they employ as baggage handlers and retail salespeople, amongst others, can get to work ensures the continued efficient operations of the airport and the ...

  4. In vitro intestinal transport of a poorly aqueous soluble drug and p-glycoprotein efflux using biorelevant medium simulating the intestinal fluids

    E-Print Network [OSTI]

    Lind, M. L.; Jacobsen, J.; Holm, R.; Mü llertz, A.

    2006-10-27

    In vitro intestinal transport of a poorly aqueous soluble drug and efflux using biorelevant medium simulating the intestinal fluids Marianne L. Lind 1,3 , Jette Jacobsen 1 , Ren? Holm 2 , Anette M?llertz 1 1 Department of Pharmaceutics... of the Caco-2 cell culture model, biorelevant media (BM) simulating the intestinal fluids have been tested for compatibility with the model (1). Use of BM in the Caco-2 cell model has previously been shown to affect transport of drugs (2). Poorly aqueous...

  5. Algebra (Informatica) 24 marzo 2004 Con pi`u di 18 punti si pu`o fare l'orale o accettare il voto dello scritto (30 e lode per chi

    E-Print Network [OSTI]

    Catenacci, Roberto

    Algebra (Informatica) ­ 24 marzo 2004 Con pi`u di 18 punti si pu`o fare l'orale o accettare il voto

  6. Algebra (Informatica) 22 giugno 2004 Con 18 o pi`u punti si pu`o fare l'orale o accettare il voto dello scritto (30 e lode per chi risolve

    E-Print Network [OSTI]

    Catenacci, Roberto

    Algebra (Informatica) ­ 22 giugno 2004 Con 18 o pi`u punti si pu`o fare l'orale o accettare il voto

  7. Transportation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservationBio-Inspired SolarAbout / Transforming Y-12Capacity-Forum Sign InTransportation

  8. Application of Smart Card fare payment data to bus network planning in London, UK

    E-Print Network [OSTI]

    Seaborn, Catherine Whitney

    2008-01-01

    This research contributes to an emerging body of literature on the application of smart card data to public transportation planning. It also addresses interchange planning, a key component of public transportation network ...

  9. Ozone uptake by citrus trees exposed to a range of ozone concentrations Silvano Fares a,b,*, Jeong-Hoo Park a

    E-Print Network [OSTI]

    Goldstein, Allen

    Ozone uptake by citrus trees exposed to a range of ozone concentrations Silvano Fares a,b,*, Jeong Received in revised form 26 May 2010 Accepted 2 June 2010 Keywords: Ozone fluxes Citrus Tropospheric ozone climates. In the summer, orchards in California experience high levels of tropospheric ozone, formed

  10. Effects of Atmospheric Ozone on Microarray Data Thomas L. Fare, Ernest M. Coffey, Hongyue Dai, Yudong D. He, Deborah A. Kessler,

    E-Print Network [OSTI]

    Kilian, Kristopher A.

    Effects of Atmospheric Ozone on Microarray Data Quality Thomas L. Fare, Ernest M. Coffey, Hongyue. Ozone levels were monitored and highly correlated with the batch effect. Controlled exposures of microarrays to ozone confirmed this factor as the root cause, and we present data that show susceptibility

  11. Antiarrhythmic Drugs

    E-Print Network [OSTI]

    Abbott, GW; Levi, R

    2012-01-01

    of beta blockers: from antianginal drugs to ligand-directedmechanisms of gating and drug block of sodium channels.Roden DM. Antiarrhythmic drugs: past, present and future. J

  12. Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice

    SciTech Connect (OSTI)

    Fu, Zidong Donna; Klaassen, Curtis D.

    2014-01-01

    Calorie restriction (CR) is one of the most effective anti-aging interventions in mammals. A modern theory suggests that aging results from a decline in detoxification capabilities and thus accumulation of damaged macromolecules. The present study aimed to determine how short-term CR alters mRNA profiles of genes that encode metabolism and detoxification machinery in the liver. Male C57BL/6 mice were fed CR (0, 15, 30, or 40%) diets for one month, followed by mRNA quantification of 98 xenobiotic processing genes (XPGs) in the liver, including 7 uptake transporters, 39 phase-I enzymes, 37 phase-II enzymes, 10 efflux transporters, and 5 transcription factors. In general, 15% CR did not alter mRNAs of most XPGs, whereas 30 and 40% CR altered over half of the XPGs (32 increased and 29 decreased). CR up-regulated some phase-I enzymes (fold increase), such as Cyp4a14 (12), Por (2.3), Nqo1 (1.4), Fmo2 (5.4), and Fmo3 (346), and numerous number of phase-II enzymes, such as Sult1a1 (1.2), Sult1d1 (2.0), Sult1e1 (33), Sult3a1 (2.2), Gsta4 (1.3), Gstm2 (1.3), Gstm3 (1.7), and Mgst3 (2.2). CR feminized the mRNA profiles of 32 XPGs in livers of male mice. For instance, CR decreased the male-predominantly expressed Oatp1a1 (97%) and increased the female-predominantly expressed Oatp1a4 (11). In conclusion, short-term CR alters the mRNA levels of over half of the 98 XPGs quantified in livers of male mice, and over half of these alterations appear to be due to feminization of the liver. - Highlights: • Utilized a graded CR model in male mice • The mRNA profiles of xenobiotic processing genes (XPGs) in liver were investigated. • CR up-regulates many phase-II enzymes. • CR tends to feminize the mRNA profiles of XPGs.

  13. Sustainable Transport

    E-Print Network [OSTI]

    Webber, Melvin

    2006-01-01

    THOUGHT PIECE Sustainable Transport by Melvin M. Webberwant to sustain any mode of transport only if we judge it todraconian in rejecting transport modes that have failed in

  14. Exploring transport and phase behavior in nanoporous carbon materials

    E-Print Network [OSTI]

    Shimizu, Steven (Steven Franklin Esau)

    2015-01-01

    Understanding transport and phase behavior in nanopores has a substantial impact on applications involving membrane fabrication, single-molecule detection, oil reservoir modeling, and drug delivery. While transport and ...

  15. DRUG DELIVERY IN BIOLOGICAL TISSUES: AN APPLICATION TO THE ELUTING STENT

    E-Print Network [OSTI]

    Pontrelli, Giuseppe

    DRUG DELIVERY IN BIOLOGICAL TISSUES: AN APPLICATION TO THE ELUTING STENT G. Pontrelli1 , F. de Monte2 , M. Prosi3 1. ABSTRACT The drug diffusion process through an arterial eluting stent is studied and a quantitative description for drug transport to evaluate feasibility of new drug delivery strategies

  16. DEVELOPMENTAL REGULATION OF THE DRUG-PROCESSING GENOME IN MOUSE LIVER

    E-Print Network [OSTI]

    Cui, Yue

    2010-07-29

    Despite the recent progress in understanding the expression patterns and regulatory mechanisms of drug-processing genes, namely phase-I and -II drug metabolizing enzymes and transporters in adults, very little is known of ...

  17. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  18. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  19. Drug interactions evaluation: An integrated part of risk assessment of therapeutics

    SciTech Connect (OSTI)

    Zhang, Lei; Reynolds, Kellie S.; Zhao, Ping [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States); Huang, Shiew-Mei, E-mail: shiewmei.huang@fda.hhs.go [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States)

    2010-03-01

    Pharmacokinetic drug interactions can lead to serious adverse events or decreased drug efficacy. The evaluation of a new molecular entity's (NME's) drug-drug interaction potential is an integral part of risk assessment during drug development and regulatory review. Alteration of activities of enzymes or transporters involved in the absorption, distribution, metabolism, or excretion of a new molecular entity by concomitant drugs may alter drug exposure, which can impact response (safety or efficacy). The recent Food and Drug Administration (FDA) draft drug interaction guidance ( (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072101.pdf)) highlights the methodologies and criteria that may be used to guide drug interaction evaluation by industry and regulatory agencies and to construct informative labeling for health practitioner and patients. In addition, the Food and Drug Administration established a 'Drug Development and Drug Interactions' website to provide up-to-date information regarding evaluation of drug interactions ( (http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm080499.htm)). This review summarizes key elements in the FDA drug interaction guidance and new scientific developments that can guide the evaluation of drug-drug interactions during the drug development process.

  20. Non-Tracial Free Transport and Applications

    E-Print Network [OSTI]

    Nelson, Brent Andrew

    2015-01-01

    tracial transport . . . . . . . . . . . . . . . . . . . .the transport element . . . . . . . . . . . . . .Free Transport . . . . . . . . . . . .

  1. Exanthematous allergic drug reactions due to four chemically unrelated drugs

    E-Print Network [OSTI]

    Gupta, Ramji; Gupta, Sameer

    2008-01-01

    16. Lachgar T, Touil Y. The drug hypersensitivity syndromeW, Bircher A, Romano A et al. Drug provocation testing inthe diagnosis of drug hypersensitivity reactions: general

  2. Resistance to currently used drugs is a serious problem in most fields of antimicrobial chemotherapy. Crossresistance

    E-Print Network [OSTI]

    Schnaufer, Achim

    Resistance to currently used drugs is a serious problem in most fields of antimicrobial chemotherapy. Crossresistance between two of the major classes of drug used in the treat- ment of African as a result of alterations in an unusual adenosine transporter involved in the uptake of these drugs. African

  3. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01

    and the risk of illicit drug use: the Adverse Childhoodalcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.

  4. Sustainable Transportation

    SciTech Connect (OSTI)

    2012-09-01

    This document highlights DOE's Office of Energy Efficiency and Renewable Energy's advancements in transportation technologies, alternative fuels, and fuel cell technologies.

  5. Orphanet Berichtsreihe Orphan Drugs Datenerhebung

    E-Print Network [OSTI]

    Manstein, Dietmar J.

    Orphanet Berichtsreihe Orphan Drugs Datenerhebung Verzeichnis der in Europa zugelassenen Orphan Drugs Mit europäischer Orphan-Drug-Designation und europäischer Marktzulassung* Mit europäischer Marktzulassung* ohne vorherige Orphan-Drug-Designation *Zentrales Zulassungsverfahren der Europäischen

  6. Transportation Plan 

    E-Print Network [OSTI]

    Boreo, Andrea; Li, Wei; Wunnenbuger, Douglas; Giusti, Cecilia; Cooper, John T.; Masterson, Jaimie

    2015-01-01

    Mobility throughout a community ensures freedom of movement and enhances quality of life. Traffic congestion, pollution, urban sprawl, social exclusion, safety and health can decrease mobility and should be a part of a sustainable transportation...

  7. electrifyingthefuture transportation

    E-Print Network [OSTI]

    Birmingham, University of

    programme of electrification and the potential introduction of diesel hybrids. The Department for Transport vehicles Wind turbine systems Industrial equipment The lab has full ethernet capability which will enable

  8. "...powered bodies turn to commodities..." -stereolab Drugs and Drug Abuse

    E-Print Network [OSTI]

    Teissére, Jeremy Alden

    "...powered bodies turn to commodities..." - stereolab BIO 115 Fall, 2008 Drugs and Drug Abuse the current narratives surrounding drug use. In parallel, we will closely examine the putative mechanisms by which drugs act in the central nervous system ­ and also discuss how the action of these drugs has

  9. Drug delivery Sustained Drug Release from Non-eroding Nanoporous

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Drug delivery Sustained Drug Release from Non-eroding Nanoporous Templates** Evin Gultepe, Dattatri drug, doxorubicin (Dox), from different non-eroding nanopor- ous coatings. Detailed studies of drug phosphate-buffered saline (PBS), which is commonly employed to simulate in vivo conditions for drug release

  10. Fixed drug eruption caused by the Japanese herbal drug kakkonto

    E-Print Network [OSTI]

    Furuichi, Megumi; Hara, Hiroshi; Asano, Yukie; Makino, Teruhiko; Shimizu, Tadamichi

    2010-01-01

    Topical provocation of fixed drug eruption. Br J Dermatol.neglected offender for fixed drug eruptions. Eur J Dermatoloral and non-oral herbal drugs may cause FDE. References 1.

  11. Drug Use and Drug Policy in a Prohibition Regime

    E-Print Network [OSTI]

    MacCoun, Robert; Martin, Karin D.

    2008-01-01

    Prisoners (prior to offense), Drug-related Emergency RoomVisits, 2007 DAWN All illicit drugs Marijuana Cocaine Crack2/4/2008 - 41 Other Sentence Drug Sentence Federal Prisoners

  12. Anticoagulation Drug Therapy: A Review

    E-Print Network [OSTI]

    Harter, Katherine; Levine, Michael; Henderson, Sean O.

    2015-01-01

    et al. Anticoagulation Drug Therapy: A Review 15. NishijimaRandomized antiplatelet drugs. In: Goodman & Gilman’s The2008;24:2757-65. Cardiovasc Drugs. 2006;6:265-85. 34. Nordt

  13. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01

    alcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.outcomes in an indicated drug prevention program for high-

  14. Preface: Nonclassical Transport

    E-Print Network [OSTI]

    Bolshov, L.

    2010-01-01

    models of solute transport in highly heterogeneous geologicSemenov. 2008b. Nonclassical transport processes in geologicand L. Matveev. 2008. Transport regimes and concentration

  15. Intelligent Transport Systems

    E-Print Network [OSTI]

    Deakin, Elizabeth; Frick, Karen Trapenberg; Skabardonis, Alexander

    2009-01-01

    in Sustainable Urban Transport: City Interview Synthesis (of Leeds, Institute for Transport Studies, forthcoming.I NTELLIGENT TRANSPORT SYSTEMS LINKING TECHNOLOGY AND

  16. Sustainability and Transport

    E-Print Network [OSTI]

    Gilbert, Richard

    2006-01-01

    Gilbert is a Toronto-based transport and energy consultantof the forthcoming book Transport Revolutions: Making theand substantial transition to transport systems based on

  17. Sandia Energy - Transportation Safety

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Transportation Safety Home Stationary Power Nuclear Fuel Cycle Nuclear Energy Safety Technologies Risk and Safety Assessment Transportation Safety Transportation SafetyTara...

  18. Drug Information Chart Notes Drug ad (intrinsic bias)

    E-Print Network [OSTI]

    Fletcher, Robin

    Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company Dosage Same or different? A drug in a different dosage can be used for a different therapy. Precautions Check for pregnancy A complete book on drugs in pregnancy and lactation in bibliography. (unbiased

  19. Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4;#8201;Å

    SciTech Connect (OSTI)

    Johnson, Zachary Lee; Cheong, Cheom-Gil; Lee, Seok-Yong (Duke)

    2012-07-11

    Nucleosides are required for DNA and RNA synthesis, and the nucleoside adenosine has a function in a variety of signalling processes. Transport of nucleosides across cell membranes provides the major source of nucleosides in many cell types and is also responsible for the termination of adenosine signalling. As a result of their hydrophilic nature, nucleosides require a specialized class of integral membrane proteins, known as nucleoside transporters (NTs), for specific transport across cell membranes. In addition to nucleosides, NTs are important determinants for the transport of nucleoside-derived drugs across cell membranes. A wide range of nucleoside-derived drugs, including anticancer drugs (such as Ara-C and gemcitabine) and antiviral drugs (such as zidovudine and ribavirin), have been shown to depend, at least in part, on NTs for transport across cell membranes. Concentrative nucleoside transporters, members of the solute carrier transporter superfamily SLC28, use an ion gradient in the active transport of both nucleosides and nucleoside-derived drugs against their chemical gradients. The structural basis for selective ion-coupled nucleoside transport by concentrative nucleoside transporters is unknown. Here we present the crystal structure of a concentrative nucleoside transporter from Vibrio cholerae in complex with uridine at 2.4 {angstrom}. Our functional data show that, like its human orthologues, the transporter uses a sodium-ion gradient for nucleoside transport. The structure reveals the overall architecture of this class of transporter, unravels the molecular determinants for nucleoside and sodium binding, and provides a framework for understanding the mechanism of nucleoside and nucleoside drug transport across cell membranes.

  20. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan Ogden and Lorraine Anderson #12;SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS #12;SUSTAINABLE;6 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS ACKNOWLEDGEMENTS #12;1 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS

  1. DRUG DISCOVERY AT PURDUE 2013-14

    E-Print Network [OSTI]

    Pittendrigh, Barry

    DRUG DISCOVERY AT PURDUE 2013-14 #12;PURDUE UNIVERSITY DRUG DISCOVERY 2 #12;PURDUE UNIVERSITY DRUG DISCOVERY 3 #12;PURDUE UNIVERSITY DRUG DISCOVERY 4 TABLE OF CONTENTS INTRODUCTION ..................................................................................................p. 8 ALPHABETICAL LIST OF DRUG DISCOVERY RESEARCHERS

  2. Beam Transport

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAudits & Inspections AuditsBarbara McClintockSecurityBeam Transport Beam

  3. Stochastic Transport

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect Photovoltaics -7541C.3X-rays3 Prepared by:'!Transport in PPCD Discharges by

  4. Greening Transportation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFESOpportunitiesNERSC GettingGraphene's 3DGreenGreenTransportation

  5. Ultrasound-Enhanced Drug Transport and Distribution in the Brain

    E-Print Network [OSTI]

    2010-01-01

    including water, mannitol, inulin, and dextran (70 kDa; ART-Da), mannitol (180 Da), inulin (5 kDa), and dextran (70 kDa;

  6. Ultrasound-Enhanced Drug Transport and Distribution in the Brain

    E-Print Network [OSTI]

    2010-01-01

    enhanced taxol delivery in brain tumor patients usingopening of the blood–brain barrier in rabbits. Radiology.and Distribution in the Brain Ying Liu, 1 Sumit Paliwal, 2

  7. Transporting particulate material

    DOE Patents [OSTI]

    Aldred, Derek Leslie (North Hollywood, CA); Rader, Jeffrey A. (North Hollywood, CA); Saunders, Timothy W. (North Hollywood, CA)

    2011-08-30

    A material transporting system comprises a material transporting apparatus (100) including a material transporting apparatus hopper structure (200, 202), which comprises at least one rotary transporting apparatus; a stationary hub structure (900) constraining and assisting the at least one rotary transporting apparatus; an outlet duct configuration (700) configured to permit material to exit therefrom and comprising at least one diverging portion (702, 702'); an outlet abutment configuration (800) configured to direct material to the outlet duct configuration; an outlet valve assembly from the material transporting system venting the material transporting system; and a moving wall configuration in the material transporting apparatus capable of assisting the material transporting apparatus in transporting material in the material transporting system. Material can be moved from the material transporting apparatus hopper structure to the outlet duct configuration through the at least one rotary transporting apparatus, the outlet abutment configuration, and the outlet valve assembly.

  8. Transportation Data Programs:Transportation Energy Data Book...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Transportation Data Programs:Transportation Energy Data Book,Vehicle Technologies Market Report, and VT Fact of the Week Transportation Data Programs:Transportation Energy Data...

  9. Oral Drug Absorption

    E-Print Network [OSTI]

    Yamashita, Shinji

    2006-10-26

    Stability 0 20 40 60 80 100 25 10 5 1 0.5 size? r 0 (?m) Fr action absor b ed in hum an (% ) Peff =5.0 Peff =3.0 Peff =1.0 Peff =0.5 Peff =0.1 Solubility? Cs = 1.0 (?g/ml) Effect of micronization on intestinal absorption of poorly soluble drugs Peff... ?? permeability to human intestine? (cm/sec x 10 -4 ) 8 Effect of Solubility on intestinal absorption of poorly soluble drugs Cs (?g/ml) 0 5 10 15 50 Fr action absor b ed in hum an (% ) 0 20 40 60 80 100 Peff =5.0 Peff =3.0 Peff =1.0 Peff =0.5 Peff =0.1 r 0 = 1...

  10. Erosion and Optimal Transport

    E-Print Network [OSTI]

    Birnir, Bjorn; Rowlett, Julie

    2010-01-01

    383 pp. EROSION AND OPTIMAL TRANSPORT [23] I. Ekeland and T.and D. Simons, Sediment transport capacity of overland ?ow,measure spaces via optimal transport, Ann. of Math. (2),

  11. Transporting Hazardous Materials

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Transporting Hazardous Materials The procedures given below apply to all materials that are considered to be hazardous by the U.S. Department of Transportation (DOT). Consult your...

  12. Sustainability and Transport

    E-Print Network [OSTI]

    Gilbert, Richard

    2006-01-01

    2005. Integrating Sustainability into the Trans- portationTHOUGHT PIECE Sustainability and Transport by Richardof the concept of sustainability to transport planning. In

  13. Systems Theory for Pharmaceutical Drug Discovery

    E-Print Network [OSTI]

    Aswani, Anil Jayanti

    2010-01-01

    model to identify multiple drug targets which can be candidates for the traditional process of drug discovery.

  14. Computational study of the transport mechanisms of molecules and ions in solid materials 

    E-Print Network [OSTI]

    Zhang, Yingchun

    2009-06-02

    Transport of ions and molecules in solids is a very important process in many technological applications, for example, in drug delivery, separation processes, and in power sources such as ion diffusion in electrodes or in ...

  15. An Analysis of the Impacts of British Transport Reforms on Transit Integration in the Metropolitan Areas

    E-Print Network [OSTI]

    Rivasplata, Charles Richard

    2006-01-01

    contrast to many other cities with the smart card system ofthe three case cities. Fare integration: transit smart cardsonly city in the country to have introduced a transit smart

  16. Drug Discovery Today Volume 11, Numbers 19/20 October 2006 REVIEWS Is the oral route possible for peptide and

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    small hydro- philic molecules that can fit in these spaces [7]. In the case of one of the most widely. Unlike conventional small molecular drugs, clinical development of these types of drug to be actively transported across the epithelial lining of the small intestine in membrane-bound vesicles after

  17. Transport Equations Thomas Hillen

    E-Print Network [OSTI]

    Hillen, Thomas

    Transport Equations Thomas Hillen supported by NSERC University of Alberta, Edmonton Transport V , V compact and symmetric. Transport Equations ­ p.2/33 #12;Directed Movement The equation pt(t, x of v. Transport Equations ­ p.3/33 #12;With Directional Changes µ: turning rate. T(v, v ): probability

  18. Motor Transport Co. 

    E-Print Network [OSTI]

    Unknown

    2011-09-05

    METROPOLITAN TRANSPORTATION PLAN Prepared by: The Longview Metropolitan Planning Organization In cooperation with: o City of Longview o City of White Oak o Gregg County o Harrison County o Texas Department of Transportation o U.S. Department... of Transportation o Federal Highway Administration o Federal Transit Administration Adopted November 12, 2009 TRANSPORTATION 2035 TABLE OF CONTENTS INTRODUCTION...

  19. Introduction Transport in disordered graphene

    E-Print Network [OSTI]

    Fominov, Yakov

    Introduction Transport in disordered graphene Summary Ballistic transport in disordered graphene P, Gornyi, Mirlin Ballistic transport in disordered graphene #12;Introduction Transport in disordered graphene Summary Outline 1 Introduction Model Experimental motivation Transport in clean graphene 2

  20. PHCL4003: Anti-infective drugs: Drugs that kill invaders -2015 Spring Course Co-Directors

    E-Print Network [OSTI]

    Marchant, Jonathan

    1 PHCL4003: Anti-infective drugs: Drugs that kill invaders - 2015 Spring Course Co to antimicrobial chemotherapy Jan. 26: 2. Principles of antibacterial drugs I: Drug targets and cytotoxicity Jan. 28: 3. Principles of antibacterial drugs II: Drug resistance Feb. 2: 4. Antibacterial drugs

  1. Certificate in Transit Management and

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    , and perform minor maintenance and staff responsibilities. UMass Transit has been a fare free public transit Intro to Transportation Systems FINOPMGT 341 Logistics & Transportation Functions FINOPMGT 347 Intro

  2. Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance

    E-Print Network [OSTI]

    Wu, Alan HB

    2011-01-01

    this article as: Wu: Drug metabolizing enzyme activitiesgenetic variances for drug of clinical pharmacogenomicPROTEOMICS Open Access Drug metabolizing enzyme activities

  3. Secure Transportation Management

    SciTech Connect (OSTI)

    Gibbs, P. W.

    2014-10-15

    Secure Transport Management Course (STMC) course provides managers with information related to procedures and equipment used to successfully transport special nuclear material. This workshop outlines these procedures and reinforces the information presented with the aid of numerous practical examples. The course focuses on understanding the regulatory framework for secure transportation of special nuclear materials, identifying the insider and outsider threat(s) to secure transportation, organization of a secure transportation unit, management and supervision of secure transportation units, equipment and facilities required, training and qualification needed.

  4. Water Transport Within the STack: Water Transport Exploratory...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Within the STack: Water Transport Exploratory Studies Water Transport Within the STack: Water Transport Exploratory Studies Part of a 100 million fuel cell award announced by DOE...

  5. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  6. Midwestern Radioactive Materials Transportation Committee Agenda...

    Office of Environmental Management (EM)

    Midwestern Radioactive Materials Transportation Committee Agenda Midwestern Radioactive Materials Transportation Committee Agenda Midwestern Radioactive Materials Transportation...

  7. Packaging and Transportation Safety

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1995-09-27

    Establishes safety requirements for the proper packaging and transportation of Department of Energy (DOE) offsite shipments and onsite transfers of hazardous materials and for modal transport. Canceled by DOE 460.1A

  8. Packaging and Transportation Safety

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2010-05-14

    The order establishes safety requirements for the proper packaging and transportation of DOE, including NNSA, offsite shipments and onsite transfers of radioactive and other hazardous materials and for modal transportation. Supersedes DOE O 460.1B.

  9. Sustainability and Transport

    E-Print Network [OSTI]

    Gilbert, Richard

    2006-01-01

    also known there as sustainable mobility. This de?nition wasfor De?ning Sustainable Transport and Mobility. [cited 13Sustainable transporta- tion is de?ned as a means to satisfy current transport and mobility

  10. Transportation Management Workshop: Proceedings

    SciTech Connect (OSTI)

    Not Available

    1993-10-01

    This report is a compilation of discussions presented at the Transportation Management Workshop held in Gaithersburg, Maryland. Topics include waste packaging, personnel training, robotics, transportation routing, certification, containers, and waste classification.

  11. Linear Motor Powered Transportation

    E-Print Network [OSTI]

    Thornton, Richard D.

    This special issue on linear-motor powered transportation covers both supporting technologies and innovative transport systems in various parts of the World, as this technology moves from the lab to commercial operations. ...

  12. Transportation Conference Speakers - 4 

    E-Print Network [OSTI]

    Unknown

    2011-08-17

    Laboratory experiments were performed to study and improve longshore sediment transport rate predictions. Measured total longshore transport in the laboratory was approximately three times greater for plunging breakers than spilling breakers. Three...

  13. Transportation Energy Futures Study

    Office of Energy Efficiency and Renewable Energy (EERE)

    Transportation accounts for 71% of total U.S. petroleum consumption and 33% of total greenhouse gas emissions. The Transportation Energy Futures (TEF) study examines underexplored oil-savings and...

  14. Transportation Market Distortions

    E-Print Network [OSTI]

    Litman, Todd

    2006-01-01

    roads and parking facilities is exempt from rent and taxes,road transport relative to rail (which pays rent and taxesroad tolls, parking fees, and Litman, Transportation Market Distortions higher fuel taxes

  15. Introduction to Transportation Planning

    E-Print Network [OSTI]

    Tipple, Brett

    Introduction to Transportation Planning CMP 4710/6710 Fall 2012 3 Credit Hours Room: ARCH 229 of City & Metropolitan Planning; Associate Dean, College of Architecture + Planning; former associate, social equity, fiscal health, and public health. Unfortunately, most transportation planning processes

  16. Transportation Conference Speakers - 1 

    E-Print Network [OSTI]

    Unknown

    2011-08-17

    Thiamin transport in Escherichia coli is a model system to establish the tolerance of derivatives for transport into the cell. Since little is known about what types of thiamin derivatives may be successfully taken into the cell through...

  17. Packaging and Transportation Safety

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1995-09-27

    Establishes safety requirements for the proper packaging and transportation of offsite shipments and onsite transfers of hazardous materials andor modal transport. Cancels DOE 1540.2 and DOE 5480.3

  18. Packaging and Transportation Safety

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-10-02

    Establishes safety requirements for the proper packaging and transportation of Department of Energy (DOE) offsite shipments and onsite transfers of hazardous materials and for modal transport. Cancels DOE O 460.1.

  19. Biofuels and Transportation

    E-Print Network [OSTI]

    Minnesota, University of

    Biofuels and Transportation Impacts and Uncertainties Some Observations of a Reformed Ethanol and Logistics Symposium 3 Topics · Why Biofuels · Ethanol Economics · Ethanol Transportation Equipment Biofuels? · National Security · Reduce Imports of oil · Peak Oil · Replace Fossil Resources

  20. Indianapolis Public Transportation Corporation

    SciTech Connect (OSTI)

    Not Available

    2004-12-01

    Fact sheet describes the National Renewable Energy Laboratory's evaluation of Indianapolis Public Transportation Corporation's (IndyGo's) hybrid electric buses.

  1. Parking & Transportation Services Sustainability &

    E-Print Network [OSTI]

    Minnesota, University of

    : 2011 #12;As a long-time leader in the areas of waste abatement, pollution reduction, energy management Metro Commuter Services Infinity Award ­ in recognition of alternative transportation programs. · 1996 to maintaining impressive and viable alternative transportation programs. TRANSPORTATION SYSTEM DESIGNS

  2. Analysis of Assembly Bill 310: Prescription Drugs

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01

    pdf. Accessed February 2011. Medco. 2010 Drug Trend Report.www.drugtrend.com/art/drug_trend/pdf/DT_Report_2010.pdf.chronic myeloid leukaemia. Drugs. 2007;67(2): p. 299- April

  3. Prescription Drug List effective January 1, 2015

    E-Print Network [OSTI]

    Arnold, Jonathan

    1 Your 2015 Prescription Drug List effective January 1, 2015 Student Resources Traditional ThreeZIPcode. ·Lookuppossiblelower-costmedicationalternatives. ·Comparemedicationpricingandoptions. #12;2 Your Prescription Drug List This Prescription Drug List (PDL) outlines the most commonly prescribed medications for certain

  4. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release is controlled by polymer degradation

  5. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    1 Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable The biodegradable polymer such as poly(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release

  6. Drug-Drug Interaction Detection: A New Approach Based on Maximal Frequent Sequences

    E-Print Network [OSTI]

    Rosso, Paolo

    Drug-Drug Interaction Detection: A New Approach Based on Maximal Frequent Sequences Detecci´on de´armacos, extracci´on de relaciones, secuencias frecuentes maximales Abstract: In this paper, a new approach for Drug-Drug that contain Drug-Drug Interactions. Maximal Frequent Sequences define word sequences that are frequent

  7. EBS Radionuclide Transport Abstraction

    SciTech Connect (OSTI)

    J. Prouty

    2006-07-14

    The purpose of this report is to develop and analyze the engineered barrier system (EBS) radionuclide transport abstraction model, consistent with Level I and Level II model validation, as identified in Technical Work Plan for: Near-Field Environment and Transport: Engineered Barrier System: Radionuclide Transport Abstraction Model Report Integration (BSC 2005 [DIRS 173617]). The EBS radionuclide transport abstraction (or EBS RT Abstraction) is the conceptual model used in the total system performance assessment (TSPA) to determine the rate of radionuclide releases from the EBS to the unsaturated zone (UZ). The EBS RT Abstraction conceptual model consists of two main components: a flow model and a transport model. Both models are developed mathematically from first principles in order to show explicitly what assumptions, simplifications, and approximations are incorporated into the models used in the TSPA. The flow model defines the pathways for water flow in the EBS and specifies how the flow rate is computed in each pathway. Input to this model includes the seepage flux into a drift. The seepage flux is potentially split by the drip shield, with some (or all) of the flux being diverted by the drip shield and some passing through breaches in the drip shield that might result from corrosion or seismic damage. The flux through drip shield breaches is potentially split by the waste package, with some (or all) of the flux being diverted by the waste package and some passing through waste package breaches that might result from corrosion or seismic damage. Neither the drip shield nor the waste package survives an igneous intrusion, so the flux splitting submodel is not used in the igneous scenario class. The flow model is validated in an independent model validation technical review. The drip shield and waste package flux splitting algorithms are developed and validated using experimental data. The transport model considers advective transport and diffusive transport from a breached waste package. Advective transport occurs when radionuclides that are dissolved or sorbed onto colloids (or both) are carried from the waste package by the portion of the seepage flux that passes through waste package breaches. Diffusive transport occurs as a result of a gradient in radionuclide concentration and may take place while advective transport is also occurring, as well as when no advective transport is occurring. Diffusive transport is addressed in detail because it is the sole means of transport when there is no flow through a waste package, which may dominate during the regulatory compliance period in the nominal and seismic scenarios. The advective transport rate, when it occurs, is generally greater than the diffusive transport rate. Colloid-facilitated advective and diffusive transport is also modeled and is presented in detail in Appendix B of this report.

  8. Regional Transportation Coordination Study 

    E-Print Network [OSTI]

    Golden Crescent Regional Planning Commission

    2006-01-01

    stream_source_info Golden Crescent Regional Transportation Coordination Study.pdf.txt stream_content_type text/plain stream_size 357268 Content-Encoding ISO-8859-1 stream_name Golden Crescent Regional Transportation Coordination... Study.pdf.txt Content-Type text/plain; charset=ISO-8859-1 Golden Crescent Regional Transit i Regional Transportation Coordination Study: 7-County Golden Crescent Region Regional...

  9. FUEL CELLS FOR TRANSPORTATION

    E-Print Network [OSTI]

    for Fuel Cells for Transportation Energy Efficiency and Renewable Energy Office of Transportation............................................................................................. 101 A. R&D of a 50-kW, High-Efficiency, High-Power-Density, CO-Tolerant PEM Fuel Cell Stack SystemFUEL CELLS FOR TRANSPORTATION 2 0 0 1 A N N U A L P R O G R E S S R E P O R T U.S. Department

  10. Discovering the Targets of Drugs Via Computational

    E-Print Network [OSTI]

    Discovering the Targets of Drugs Via Computational Systems Biology* Published, JBC Papers in Press is empowering the study of drug action. Studies on biological effects of chemical com- pounds have increased of drugs, with the collective potential to change the nature of drug discovery and pharmacological therapy

  11. Drug-Target Interaction Predicates Combining Similarities

    E-Print Network [OSTI]

    Daume III, Hal

    Drug-Target Interaction Predicates DataSet Combining Similarities Collective Inference Collective Inference and Multi-Relational Learning for Drug­Target Interaction Prediction Shobeir Fakhraei1, Bert Huang1 and Lise Getoor1,2 Poly-pharmacology Drug Repurposing Drug-Target Interaction Network Studies

  12. ELECTROCHEMICAL POWER FOR TRANSPORTATION

    E-Print Network [OSTI]

    Cairns, Elton J.

    2012-01-01

    of the Fuel Cell in Transportation Applications Workshop,practical fuel cell for commercial or consumer applicationfuel cell system engineer- ing is made, vehicle applications

  13. National Transportation Stakeholders Forum

    Office of Environmental Management (EM)

    Nuclear Fuel Grand BC and High-Level Radioactive Waste - Jeff Williams, Director, Nuclear Fuel Storage and Transportation Planning Project, DOEOffice of Nuclear Energy National...

  14. Radioactive Material Transportation Practices

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2002-09-23

    Establishes standard transportation practices for Departmental programs to use in planning and executing offsite shipments of radioactive materials including radioactive waste. Does not cancel other directives.

  15. Transportation Energy Futures Snapshot

    Office of Energy Efficiency and Renewable Energy (EERE)

    This snapshot is a summary of the EERE reports that provide a detailed analysis of opportunities and challenges along the path to a more sustainable transportation energy future.

  16. Transportation and its Infrastructure

    E-Print Network [OSTI]

    2007-01-01

    gas vehicles Annual road tax differentiated by vintageand charges for road transport Tax/pricing measure Optimalannual circulation taxes, tolls and road charges and parking

  17. Transportation Energy Futures

    E-Print Network [OSTI]

    Sperling, Daniel

    1989-01-01

    TRANSPORTATION ment of Oil Shale Technology. Washing- ton,interest and investments in oil shale, ethanol, coal liquidsbiomass materials, coal, oil shale, tar sands, natural gas,

  18. UZ Colloid Transport Model

    SciTech Connect (OSTI)

    M. McGraw

    2000-04-13

    The UZ Colloid Transport model development plan states that the objective of this Analysis/Model Report (AMR) is to document the development of a model for simulating unsaturated colloid transport. This objective includes the following: (1) use of a process level model to evaluate the potential mechanisms for colloid transport at Yucca Mountain; (2) Provide ranges of parameters for significant colloid transport processes to Performance Assessment (PA) for the unsaturated zone (UZ); (3) Provide a basis for development of an abstracted model for use in PA calculations.

  19. Transportation and its Infrastructure

    E-Print Network [OSTI]

    2007-01-01

    of reduction options/ AERO. Ministry of Transport, Publicfrom aviation with the AERO modeling system Part I.from aviation with the AERO modeling system. Montreal,

  20. Natural Gas Transportation Resiliency

    Broader source: Energy.gov (indexed) [DOE]

    Transportation Resiliency Anders Johnson Director Pipeline System Design April 29, 2014 Confidential and Illustrative for discussion purposes only. The views expressed in this...

  1. Transportation Energy Futures Snapshot

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    modes, manage the demand for transportation, and shift the fuel mix to more sustainable sources necessary to reach these significant outcomes. Coordinating a...

  2. WASTE PACKAGE TRANSPORTER DESIGN

    SciTech Connect (OSTI)

    D.C. Weddle; R. Novotny; J. Cron

    1998-09-23

    The purpose of this Design Analysis is to develop preliminary design of the waste package transporter used for waste package (WP) transport and related functions in the subsurface repository. This analysis refines the conceptual design that was started in Phase I of the Viability Assessment. This analysis supports the development of a reliable emplacement concept and a retrieval concept for license application design. The scope of this analysis includes the following activities: (1) Assess features of the transporter design and evaluate alternative design solutions for mechanical components. (2) Develop mechanical equipment details for the transporter. (3) Prepare a preliminary structural evaluation for the transporter. (4) Identify and recommend the equipment design for waste package transport and related functions. (5) Investigate transport equipment interface tolerances. This analysis supports the development of the waste package transporter for the transport, emplacement, and retrieval of packaged radioactive waste forms in the subsurface repository. Once the waste containers are closed and accepted, the packaged radioactive waste forms are termed waste packages (WP). This terminology was finalized as this analysis neared completion; therefore, the term disposal container is used in several references (i.e., the System Description Document (SDD)) (Ref. 5.6). In this analysis and the applicable reference documents, the term ''disposal container'' is synonymous with ''waste package''.

  3. Sustainable Transportation (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2012-09-01

    This document highlights DOE's Office of Energy Efficiency and Renewable Energy's advancements in transportation technologies, alternative fuels, and fuel cell technologies.

  4. CALIFORNIA CENTER FOR INNOVATIVE TRANSPORTATION INSTITUTE OF TRANSPORTATION STUDIES

    E-Print Network [OSTI]

    CALIFORNIA CENTER FOR INNOVATIVE TRANSPORTATION INSTITUTE OF TRANSPORTATION STUDIES UNIVERSITY Investigator CCIT Research Report UCB-ITS-CWP-2011-2 The California Center for Innovative Transportation works;CALIFORNIA CENTER FOR INNOVATIVE TRANSPORTATION INSTITUTE OF TRANSPORTATION STUDIES UNIVERSITY OF CALIFORNIA

  5. Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic

    E-Print Network [OSTI]

    Daume III, Hal

    Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic Shobeir, USA getoor@cs.umd.edu ABSTRACT The high development cost and low success rate of drug dis- covery from appro- ved drugs. Computational methods can be effective in focu- sing efforts for such drug repurposing

  6. An approach to drug delivery using novel carbohydrates to carry drugs

    E-Print Network [OSTI]

    Davis, Ben G.

    An approach to drug delivery using novel carbohydrates to carry drugs has recently been described of the cancer drug doxorubicin targeted to hepatocytes in a mouse liver tumour model. Known as the LEAPT step involves administering the rhamnose-capped pro-drug; the drug is activated in the target cell once

  7. Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates to paclitaxel and the subsequent ring-opening polymerization of lactide. The drug-initiated, controlled(-caprolactone)) was also achieved through drug/(BDI-II)ZnN(TMS)2-mediated controlled polymerization. These drug

  8. Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug-

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug- Poly(Ocarboxyanhydride) Nanoconjugates Qian Yin, Rong Tong,, Yunxiang Xu, Kwanghyun Baek of polymer-drug conjugates for nanoparticulate drug delivery: hydroxyl-containing drug (e.g., camptothecin

  9. Alcohol and Other Drugs -1 -Approved: 05/09/2014 Alcohol and Other Drugs

    E-Print Network [OSTI]

    Hammack, Richard

    Alcohol and Other Drugs - 1 - Approved: 05/09/2014 Alcohol and Other Drugs Policy Type: Board with the federal Drug Free Workplace Act of 1988, the federal Drug Free Schools and Communities Act of 1989, and the Commonwealth of Virginia's Policy on Alcohol and Other Drugs (AOD), it is the policy of Virginia Commonwealth

  10. Transportation Todd Litman

    E-Print Network [OSTI]

    consumer cost savings. #12;11 Per Capita Transport EnergyPer Capita Transport Energy 0 0.5 1 1.5 2 2.5 D Problem? · Traffic congestion? · Road construction costs? · Parking congestion or costs? · Excessive costs to consumers? · Government costs? · Traffic crashes? · Lack of mobility for non-drivers? · Poor freight

  11. Expert systems in transportation

    SciTech Connect (OSTI)

    O'Leary, K.P.

    1988-01-01

    The 5 papers in the report deal with the following areas: Knowledge representation and software selection for expert-systems design; Expert-system architecture for retaining-wall design; Development of expert-systems technology in the California Department of Transportation; Development of an expert system to assist in the interactive graphic transit system design process; Expert systems development for contingency transportation planing.

  12. Packaging and Transportation Safety

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-04-04

    To establish safety requirements for the proper packaging and transportation of Department of Energy (DOE)/National Nuclear Security Administration (NNSA) offsite shipments and onsite transfers of hazardous materials and for modal transport. Cancels DOE O 460.1A. Canceled by DOE O 460.1C.

  13. Transport Layer Cornell University

    E-Print Network [OSTI]

    Low, Steven H.

    Transport Layer Ao Tang Cornell University Ithaca, NY 14853 Lachlan L. H. Andrew California. Low California Institute of Technology Pasadena, CA 91125 I. INTRODUCTION The Internet has evolved of the physical layer, the link layer, the network layer, the transport layer and the application layer1 . See

  14. TRANSPORTATION ENERGY RESEARCH PIER Transportation Research

    E-Print Network [OSTI]

    . The project also tested a Caterpillar C15 engine certified to 2007 U.S. Environmental Protection Agency.energy.ca.gov/research/ transportation/ January 2011 Heavy-Duty Vehicle Emissions and Fuel Consumption Improvement Illustration of a heavy-duty tractor-trailer modified to meet the SmartWayTM Equipment Standards for lower fuel

  15. STRUCTURAL REQUIREMENTS OF ORGANIC ANION TRANSPORTING POLYPEPTIDE MEDIATED TRANSPORT

    E-Print Network [OSTI]

    Weaver, Yi Miao

    2010-04-12

    The organic anion transporting polypeptides (human: OATP; other: Oatp) form a mammalian transporter superfamily that mediates the transport of structurally unrelated compounds across the cell membrane. Members in this superfamily participate...

  16. Essays on Urban Transportation and Transportation Energy Policy

    E-Print Network [OSTI]

    Kim, Chun Kon

    2008-01-01

    and Transportation Energy Policy Chun Kon Kim University of California,California Goyang, KOREA viii P???????????? ??? W?????? P????? The Impacts of Transportation EnergyCalifornia Transportation Center (UCTC) Regents’ Dissertation Fellowship University of California, Irvine California Energy

  17. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

    E-Print Network [OSTI]

    Carlyle, Wenda C.

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

  18. Drug Trafficking Organizations and Counter-Drug Strategies in the U.S.-Mexican Context

    E-Print Network [OSTI]

    Astorga, Luis; Shirk, David A.

    2010-01-01

    Analytic Assessment of U.S. Drug Policy. Washington, D.C. ,K. (2008). Mexico Faces New Drug Challenge: Mini-Submarines.Mayors on Front Line of the Drug War. Los Angeles Times Los

  19. Implementing Advances in Transport Security Technologies | Department...

    Office of Environmental Management (EM)

    Implementing Advances in Transport Security Technologies Implementing Advances in Transport Security Technologies Implementing Advances in Transport Security Technologies More...

  20. Transportation Storage Interface | Department of Energy

    Office of Environmental Management (EM)

    Storage Interface Transportation Storage Interface Regulation of Future Extended Storage and Transportation. Transportation Storage Interface More Documents & Publications Gap...

  1. Automated Transportation Logistics and Analysis System (ATLAS...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Packaging and Transportation Automated Transportation Logistics and Analysis System (ATLAS) Automated Transportation Logistics and Analysis System (ATLAS) The Department of...

  2. Transport Services (TAPS) BOF plan

    E-Print Network [OSTI]

    Welzl, Michael

    Transport Services (TAPS) BOF plan T. Moncaster, M. Welzl, D. Ros: dra5-moncaster-tsvwg-transport-services-00 h Reducing Internet Transport Latency Michael Welzl, with help from (alphabe/cal): Anna

  3. Brain science, addiction and drugs

    E-Print Network [OSTI]

    Wiesner, Karoline

    Designing your future Page 7 Theme: Nanoscience and Quantum Information Exchanging keys in the Canaries Page:searchUniversity of Bristol · Research Review · Issue 10 · October 2005 research themes issue #12;Research themes 2005 Establishedresearchthemes Theme: Neuroscience Brain science, addiction and drugs Other established research themes

  4. Improving Efficiency and Equity in Transportation Finance

    E-Print Network [OSTI]

    Watts, Michael

    2006-01-01

    Fueling Transportation Finance. ” Ian W. H. Parry andFueling Transportation Finance. ” Transportation ResearchFueling Transportation Finance: A Primer on the Gas Tax •

  5. Superconnections and Parallel Transport

    E-Print Network [OSTI]

    Dumitrescu, Florin

    2007-01-01

    This note addresses the construction of a notion of parallel transport along superpaths arising from the concept of a superconnection on a vector bundle over a manifold $M$. A superpath in $M$ is, loosely speaking, a path in $M$ together with an odd vector field in $M$ along the path. We also develop a notion of parallel transport associated with a connection (a.k.a. covariant derivative) on a vector bundle over a \\emph{supermanifold} which is a direct generalization of the classical notion of parallel transport for connections over manifolds.

  6. EBS Radionuclide Transport Abstraction

    SciTech Connect (OSTI)

    J.D. Schreiber

    2005-08-25

    The purpose of this report is to develop and analyze the engineered barrier system (EBS) radionuclide transport abstraction model, consistent with Level I and Level II model validation, as identified in ''Technical Work Plan for: Near-Field Environment and Transport: Engineered Barrier System: Radionuclide Transport Abstraction Model Report Integration'' (BSC 2005 [DIRS 173617]). The EBS radionuclide transport abstraction (or EBS RT Abstraction) is the conceptual model used in the total system performance assessment for the license application (TSPA-LA) to determine the rate of radionuclide releases from the EBS to the unsaturated zone (UZ). The EBS RT Abstraction conceptual model consists of two main components: a flow model and a transport model. Both models are developed mathematically from first principles in order to show explicitly what assumptions, simplifications, and approximations are incorporated into the models used in the TSPA-LA. The flow model defines the pathways for water flow in the EBS and specifies how the flow rate is computed in each pathway. Input to this model includes the seepage flux into a drift. The seepage flux is potentially split by the drip shield, with some (or all) of the flux being diverted by the drip shield and some passing through breaches in the drip shield that might result from corrosion or seismic damage. The flux through drip shield breaches is potentially split by the waste package, with some (or all) of the flux being diverted by the waste package and some passing through waste package breaches that might result from corrosion or seismic damage. Neither the drip shield nor the waste package survives an igneous intrusion, so the flux splitting submodel is not used in the igneous scenario class. The flow model is validated in an independent model validation technical review. The drip shield and waste package flux splitting algorithms are developed and validated using experimental data. The transport model considers advective transport and diffusive transport from a breached waste package. Advective transport occurs when radionuclides that are dissolved or sorbed onto colloids (or both) are carried from the waste package by the portion of the seepage flux that passes through waste package breaches. Diffusive transport occurs as a result of a gradient in radionuclide concentration and may take place while advective transport is also occurring, as well as when no advective transport is occurring. Diffusive transport is addressed in detail because it is the sole means of transport when there is no flow through a waste package, which may dominate during the regulatory compliance period in the nominal and seismic scenarios. The advective transport rate, when it occurs, is generally greater than the diffusive transport rate. Colloid-facilitated advective and diffusive transport is also modeled and is presented in detail in Appendix B of this report.

  7. Transportation and Greenhouse Gas Mitigation

    E-Print Network [OSTI]

    Lutsey, Nicholas P.; Sperling, Dan

    2008-01-01

    natural gas and liquefied petroleum gas have continued to make small contributions to transportation,transportation actions include electric power sector actions, eg coal to natural gas

  8. Office of Secure Transportation Activities

    Office of Environmental Management (EM)

    6th, 2012 WIPP Knoxville, TN OFFICE OF SECURE TRANSPORTATION Agency Integration Briefing Our Mission To provide safe and secure ground and air transportation of nuclear weapons,...

  9. Spent Fuel Transportation Risk Assessment

    Office of Environmental Management (EM)

    Spent Fuel Transportation Risk Assessment (SFTRA) Draft NUREG-2125 Overview for National Transportation Stakeholders Forum John Cook Division of Spent Fuel Storage and...

  10. Transportation and its Infrastructure

    E-Print Network [OSTI]

    2007-01-01

    IEA personnel (WBCSD, 2004b), the WEO 2004 and Mobility 2030are quite similar. The WEO 2006 (IEA, 2006b) includes higherwhile the IEA’s more recent WEO 2006 projects transport

  11. Optimization of Maritime Transportation

    E-Print Network [OSTI]

    Grossmann, Ignacio E.

    and Technology Management Norwegian University of Science and Technology, Trondheim, Norway Enterprise and D. Ronen (2007). Maritime transportation. Handbooks in Operations Research and Management Science (consolidation in the manufacturing sector, increasing competition, profit margins reduced, mergers and pooling

  12. Accident resistant transport container

    DOE Patents [OSTI]

    Andersen, John A. (Albuquerque, NM); Cole, James K. (Albuquerque, NM)

    1980-01-01

    The invention relates to a container for the safe air transport of plutonium having several intermediate wood layers and a load spreader intermediate an inner container and an outer shell for mitigation of shock during a hypothetical accident.

  13. Transportation Baseline Report

    SciTech Connect (OSTI)

    Fawcett, Ricky Lee; Kramer, George Leroy Jr.

    1999-12-01

    The National Transportation Program 1999 Transportation Baseline Report presents data that form a baseline to enable analysis and planning for future Department of Energy (DOE) Environmental Management (EM) waste and materials transportation. In addition, this Report provides a summary overview of DOE’s projected quantities of waste and materials for transportation. Data presented in this report were gathered as a part of the IPABS Spring 1999 update of the EM Corporate Database and are current as of July 30, 1999. These data were input and compiled using the Analysis and Visualization System (AVS) which is used to update all stream-level components of the EM Corporate Database, as well as TSD System and programmatic risk (disposition barrier) information. Project (PBS) and site-level IPABS data are being collected through the Interim Data Management System (IDMS). The data are presented in appendices to this report.

  14. Atmospheric Transport of Radionuclides

    SciTech Connect (OSTI)

    Crawford, T.V.

    2003-03-03

    The purpose of atmospheric transport and diffusion calculations is to provide estimates of concentration and surface deposition from routine and accidental releases of pollutants to the atmosphere. This paper discusses this topic.

  15. National Transportation Stakeholders Forum

    Office of Environmental Management (EM)

    next webinar is scheduled to occur in June 2013 TRIBAL NATIONS CAUCUS UPDATE WIKI AND NTSF WEB SITES ntsf.wikidot.com www.em.doe.govPagesNationalTransportationForum.aspx...

  16. Transport in granular systems

    E-Print Network [OSTI]

    Wendell, Dawn M. (Dawn Marie), 1983-

    2011-01-01

    There are many situations in which a continuum view of granular systems does not fully capture the relevant mechanics. In order for engineers to be able to design systems for transporting granular materials, there needs ...

  17. Transportation Storage Interface

    Office of Environmental Management (EM)

    in above- ground bunkers, each of which is about the size of a one-car garage. Spent Fuel Storage: Dual Purpose Cask Systems 8 Spent Fuel Storage and Transportation: Framework...

  18. PBA Transportation Websites

    Broader source: Energy.gov [DOE]

    PBA Transportation Websites presented to the DOE Systems Analysis Workshop held in Washington, D.C. July 28-29, 2004 to discuss and define role of systems analysis in DOE Hydrogen Program.

  19. 1.259J / 11.542J / ESD.227J Transit Management, Spring 2003

    E-Print Network [OSTI]

    Wilson, Nigel H. M.

    Management methods of relevance to public transportation systems. Topics: strategic planning management; labor relations; maintenance planning and administration; financing; marketing and fare policy; and management ...

  20. Fluid transport container

    DOE Patents [OSTI]

    DeRoos, B.G.; Downing, J.P. Jr.; Neal, M.P.

    1995-11-14

    An improved fluid container for the transport, collection, and dispensing of a sample fluid that maintains the fluid integrity relative to the conditions of the location at which it is taken. More specifically, the invention is a fluid sample transport container that utilizes a fitting for both penetrating and sealing a storage container under controlled conditions. Additionally, the invention allows for the periodic withdrawal of portions of the sample fluid without contamination or intermixing from the environment surrounding the sample container. 13 figs.

  1. Transportation fuels from wood

    SciTech Connect (OSTI)

    Baker, E.G.; Elliott, D.C.; Stevens, D.J.

    1980-01-01

    The various methods of producing transportation fuels from wood are evaluated in this paper. These methods include direct liquefaction schemes such as hydrolysis/fermentation, pyrolysis, and thermochemical liquefaction. Indirect liquefaction techniques involve gasification followed by liquid fuels synthesis such as methanol synthesis or the Fischer-Tropsch synthesis. The cost of transportation fuels produced by the various methods are compared. In addition, three ongoing programs at Pacific Northwest Laboratory dealing with liquid fuels from wood are described.

  2. Packaging for a drug delivery microelectromechanical system

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2005-01-01

    Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

  3. Financing drug discovery for orphan diseases

    E-Print Network [OSTI]

    Fagnan, David Erik

    Recently proposed ‘megafund’ financing methods for funding translational medicine and drug development require billions of dollars in capital per megafund to de-risk the drug discovery process enough to issue long-term ...

  4. The pipeline and future of drug development in schizophrenia

    E-Print Network [OSTI]

    Gray, J A; Roth, B L

    2007-01-01

    The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

  5. Membrane Transport Chloride Transport Across Vesicle and Cell

    E-Print Network [OSTI]

    Smith, Bradley D.

    Membrane Transport Chloride Transport Across Vesicle and Cell Membranes by Steroid-Based Receptors-established that molecules which transport cations across cell membranes (cationophores) can have potent biological effects of biological activity. Indeed, chloride transporters have direct medical potential as treatments for cystic

  6. Parking and Transport Policy Page 1 Parking and Transport Policy

    E-Print Network [OSTI]

    Mucina, Ladislav

    Parking and Transport Policy Page 1 Parking and Transport Policy Category: Facilities, Campus Life 1. PURPOSE To standardise and manage parking and transport on the Curtin Bentley campus including that support both State Government and University objectives in a manner that encourages public transport use

  7. CALIFORNIA CENTER FOR INNOVATIVE TRANSPORTATION INSTITUTE OF TRANSPORTATION STUDIES

    E-Print Network [OSTI]

    CALIFORNIA CENTER FOR INNOVATIVE TRANSPORTATION INSTITUTE OF TRANSPORTATION STUDIES UNIVERSITY-ITS-CWP-2010-4 This work was performed by the California Center for Innovative Transportation, a research group at the University of California, Berkeley, in cooperation with the State of California Business, Transportation

  8. CALIFORNIA CENTER FOR INNOVATIVE TRANSPORTATION INSTITUTE OF TRANSPORTATION STUDIES

    E-Print Network [OSTI]

    CALIFORNIA CENTER FOR INNOVATIVE TRANSPORTATION INSTITUTE OF TRANSPORTATION STUDIES UNIVERSITY-ITS-CWP-2011-6 ISSN 1557-2269 The California Center for Innovative Transportation works with researchers that improve the efficiency, safety, and security of the transportation system. #12;#12;CALIFORNIA CENTER

  9. Predicting new molecular targets for known drugs

    E-Print Network [OSTI]

    Kaski, Samuel

    ARTICLES Predicting new molecular targets for known drugs Michael J. Keiser1,2 *, Vincent Setola3 drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug­target combinations exist, it would be useful to explore possible

  10. CMVO Drug Testing Program Reasonable Suspicion Testing

    E-Print Network [OSTI]

    Sin, Peter

    CMVO Drug Testing Program Reasonable Suspicion Testing CMVO Revised Suspicion Form (Revised 6/08) Guidelines for Reasonable Suspicion Drug and Alcohol Testing: A supervisor, trained in accordance with 49 CFR involved in an incident that requires drug/alcohol testing as set forth in 382.307. Remember: Reasonable

  11. Focus Article Open challenges in magnetic drug

    E-Print Network [OSTI]

    Shapiro, Benjamin

    Focus Article Open challenges in magnetic drug targeting Benjamin Shapiro,1,2 Sandip Kulkarni,1 Aleksander Nacev,3 Silvia Muro,1,4 Pavel Y. Stepanov3 and Irving N. Weinberg3 The principle of magnetic drug is that highlight- ing these challenges will help researchers translate magnetic drug targeting from a novel concept

  12. Drugs and Behavior (Psychology 320 Sec. 001)

    E-Print Network [OSTI]

    Hopfinger, Joseph B.

    1 Drugs and Behavior (Psychology 320 Sec. 001) Syllabus Example Text: Maisto, Galizio and Conners. Drug Use and Abuse. Harcourt Brace College Publishers. 2008, Fifth Edition. Prerequisites: This course of drugs of abuse. An overview of basic pharmacology and behavioral pharmacology will be provided followed

  13. Proctors' Memorandum on Drugs Misuse Guidelines from Proctors' Office on Dealing with Drugs Misuse

    E-Print Network [OSTI]

    Henderson, Gideon

    Proctors' Memorandum on Drugs Misuse Guidelines from Proctors' Office on Dealing with Drugs Misuse The use of specified drugs is illegal within the UK, and is inimical to the University's primary objectives of the pursuit of academic study and research. The presence of drugs within the University

  14. Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative Loading Efficiency

    E-Print Network [OSTI]

    Cheng, Jianjun

    Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative LoadingChampaign, Urbana, Illinois 61801, United States Key Laboratory of Smart Drug Delivery, Ministry of Education-molecule drugs in hydrophobic polymers or amphiphilic copolymers has been extensively used for preparing

  15. Experimenting with Drugs (and Topic Models): Multi-Dimensional Exploration of Recreational Drug Discussions

    E-Print Network [OSTI]

    Dredze, Mark

    Experimenting with Drugs (and Topic Models): Multi-Dimensional Exploration of Recreational Drug of new recreational drugs and trends re- quires mining current information from non-traditional text components. The resulting model learns factors that correspond to drug type, delivery method (smoking

  16. Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs

    E-Print Network [OSTI]

    Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs become empowered to share personal experiences regarding prescription drugs via Web page discussion from patient-provided drug reviews on health-related web sites. We focus on the statin class

  17. HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS

    E-Print Network [OSTI]

    Kim, Duck O.

    HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC AND OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS (5/3/2013) Introduction Drugs have a successful history of use in treating diseases and are responsible for many medical advances over the past century. However, virtually every drug has side effects

  18. Policy on Drug-Free Workplace Policy on Drug-Free Workplace

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Drug-Free Workplace 10/26/2014 Policy on Drug-Free Workplace I. Purpose and Scope responsible decision- making regarding the use of alcohol and other drugs. Northeastern strives to maintain drug use can create. Additionally, the University is committed to enforcing policies and laws relating

  19. NREL: Transportation Research - Transportation Deployment Support

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines lightGeospatial ToolkitSMARTSWorking WithSuccess StoriesTransportation

  20. NREL: Transportation Research - Transportation Secure Data Center

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines lightGeospatial ToolkitSMARTSWorking WithSuccessTransportation Secure Data

  1. NREL: Transportation Research - Transportation and Hydrogen Newsletter:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines lightGeospatial ToolkitSMARTSWorking WithSuccessTransportation Secure

  2. NREL: Transportation Research - Transportation and Hydrogen Newsletter:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines lightGeospatial ToolkitSMARTSWorking WithSuccessTransportation

  3. Thermal and Electrical Transport in Oxide Heterostructures

    E-Print Network [OSTI]

    Ravichandran, Jayakanth

    2011-01-01

    of thermal conductivity . . . . . . . . . . . . . . . .4.4 Thermal transport in2.3.2 Thermal transport . . . . . . . . . . . . . . . .

  4. SUMMARY OF TRAVEL AND HOSPITALITY EXPENSES FOR THE PERIOD October 1, 2014 December 31, 2014 DATE EVENT/ACTIVITY LOCATION DETAILED COSTS TOTAL

    E-Print Network [OSTI]

    Thompson, Michael

    , UK London, UK Airfare: $6,040.28 Airways Transit Transportation: $204.00 Taxi.32 Airways Transit Transportation: $179.00 Taxi Fares: $40.83 Meals: $205.22 $999.90 Airways Transit Transportation: $102.00 Taxi Fares: $72.52 Hotel Accommodation: $491

  5. Drugs in Cinema: Separating the Myths from Reality

    E-Print Network [OSTI]

    Iannicelli, Paul

    2001-01-01

    Drugs in Cinema: Separating the Myths from Reality PaulSUMMARY 7 (2000). DRUGS IN CINEMA policy has a significantviolence in film. DRUGS IN CINEMA III. HISTORY OF DRUG USE

  6. Attoheat transport phenomena

    E-Print Network [OSTI]

    J. Marciak-Kozlowska; M. Pelc; M. A. Kozlowski

    2009-06-09

    Fascinating developments in optical pulse engineering over the last 20 years lead to the generation of laser pulses as short as few femtosecond, providing a unique tool for high resolution time domain spectroscopy. However, a number of the processes in nature evolve with characteristic times of the order of 1 fs or even shorter. Time domain studies of such processes require at first place sub-fs resolution, offered by pulse depicting attosecond localization. The generation, characterization and proof of principle applications of such pulses is the target of the attoscience. In the paper the thermal processes on the attosecond scale are described. The Klein-Gordon and Proca equations are developed. The relativistic effects in the heat transport on nanoscale are discussed. It is shown that the standard Fourier equation can not be valid for the transport phenomena induced by attosecond laser pulses. The heat transport in nanoparticles and nanotubules is investigated.

  7. Multi-modal Transportation > Highway Transportation > Trucking > Railroad transportation > Public transit > Rural transportation > Rural transit > Freight pipeline transportation > Airport planning and development > Airport maintenance > Bicycle and pedes

    E-Print Network [OSTI]

    and development > Airport maintenance > Bicycle and pedestrian > Ports and waterways >>> Transportation operat and development > Airport maintenance > Bicycle and pedestrian > Ports and waterways >>> Transportation operations pipeline transportation > Airport planning and development > Airport maintenance > Bicycle and pedestrian

  8. Vaginal mesh grafts and the Food and Drug Administration

    E-Print Network [OSTI]

    Ostergard, Donald R.

    2010-01-01

    and the Food and Drug Administration Donald R. Ostergardthe food and drug administration's (FDA) 510(k) process of

  9. Heavy-flavor transport

    E-Print Network [OSTI]

    Andrea Beraudo

    2015-10-29

    The formation of a hot deconfined medium (Quark-Gluon Plasma) in high-energy nuclear collisions affects heavy-flavor observables. In the low/moderate-pT range transport calculations allow one to simulate the propagation of heavy quarks in the plasma and to evaluate the effect of the medium on the final hadronic spectra: results obtained with transport coefficients arising from different theoretical approaches can be compared to experimental data. Finally, a discussion of possible effects on heavy-flavor observables due to the possible formation of a hot-medium in small systems (like in p-A collisions) is presented.

  10. Testing Drugs Versus Testing For Drug Use: Private Risk Management in the Shadow of the Criminal Law

    E-Print Network [OSTI]

    MacCoun, Robert J.

    2007-01-01

    Preface: The Varieties of Drug Control at the Dawn of thetbl.1.1. Id. See Peter Reuter, Drug Use Measures: What AreBetween Student Illicit Drug Use and School Drug-Testing

  11. Mass Transport within Soils

    SciTech Connect (OSTI)

    McKone, Thomas E.

    2009-03-01

    Contaminants in soil can impact human health and the environment through a complex web of interactions. Soils exist where the atmosphere, hydrosphere, geosphere, and biosphere converge. Soil is the thin outer zone of the earth's crust that supports rooted plants and is the product of climate and living organisms acting on rock. A true soil is a mixture of air, water, mineral, and organic components. The relative proportions of these components determine the value of the soil for agricultural and for other human uses. These proportions also determine, to a large extent, how a substance added to soil is transported and/or transformed within the soil (Spositio, 2004). In mass-balance models, soil compartments play a major role, functioning both as reservoirs and as the principal media for transport among air, vegetation, surface water, deeper soil, and ground water (Mackay, 2001). Quantifying the mass transport of chemicals within soil and between soil and atmosphere is important for understanding the role soil plays in controlling fate, transport, and exposure to multimedia pollutants. Soils are characteristically heterogeneous. A trench dug into soil typically reveals several horizontal layers having different colors and textures. As illustrated in Figure 1, these multiple layers are often divided into three major horizons: (1) the A horizon, which encompasses the root zone and contains a high concentration of organic matter; (2) the B horizon, which is unsaturated, lies below the roots of most plants, and contains a much lower organic carbon content; and (3) the C horizon, which is the unsaturated zone of weathered parent rock consisting of bedrock, alluvial material, glacial material, and/or soil of an earlier geological period. Below these three horizons lies the saturated zone - a zone that encompasses the area below ground surface in which all interconnected openings within the geologic media are completely filled with water. Similarly to the unsaturated zone with three major horizons, the saturated zone can be further divided into other zones based on hydraulic and geologic conditions. Wetland soils are a special and important class in which near-saturation conditions exist most of the time. When a contaminant is added to or formed in a soil column, there are several mechanisms by which it can be dispersed, transported out of the soil column to other parts of the environment, destroyed, or transformed into some other species. Thus, to evaluate or manage any contaminant introduced to the soil column, one must determine whether and how that substance will (1) remain or accumulate within the soil column, (2) be transported by dispersion or advection within the soil column, (3) be physically, chemically, or biologically transformed within the soil (i.e., by hydrolysis, oxidation, etc.), or (4) be transported out of the soil column to another part of the environment through a cross-media transfer (i.e., volatilization, runoff, ground water infiltration, etc.). These competing processes impact the fate of physical, chemical, or biological contaminants found in soils. In order to capture these mechanisms in mass transfer models, we must develop mass-transfer coefficients (MTCs) specific to soil layers. That is the goal of this chapter. The reader is referred to other chapters in this Handbook that address related transport processes, namely Chapter 13 on bioturbation, Chapter 15 on transport in near-surface geological formations, and Chapter 17 on soil resuspention. This chapter addresses the following issues: the nature of soil pollution, composition of soil, transport processes and transport parameters in soil, transformation processes in soil, mass-balance models, and MTCs in soils. We show that to address vertical heterogeneity in soils in is necessary to define a characteristic scaling depth and use this to establish process-based expressions for soil MTCs. The scaling depth in soil and the corresponding MTCs depend strongly on (1) the composition of the soil and physical state of the soil, (2) the chemical and physic

  12. Contactless prepaid and bankcards in transit fare collection systems

    E-Print Network [OSTI]

    Brakewood, Candace Elizabeth

    2010-01-01

    Many public transit agencies are considering direct acceptance of contactless credit and debit cards (collectively contactless bankcards) at gates in rail stations and on board buses. Concerns have been raised about riders ...

  13. MuSa, acronimo di Musica Sapienza, significa fare, ascoltare,

    E-Print Network [OSTI]

    Di Pillo, Gianni

    spese gestionali ordinarie ed agli onorari dei soli maestri professionisti. Grazie anche all'efficienza

  14. The Bubble Has Burst - How Will California Fare?

    E-Print Network [OSTI]

    Jaffee, Dwight; Kroll, Cynthia

    2001-01-01

    energy supply system in California had affected both the cost andCalifornia’s major employers are not reliant on low cost energy (

  15. ADVANCED CUTTINGS TRANSPORT STUDY

    SciTech Connect (OSTI)

    Troy Reed; Stefan Miska; Nicholas Takach; Kaveh Ashenayi; Gerald Kane; Mark Pickell; Len Volk; Mike Volk; Barkim Demirdal; Affonso Lourenco; Evren Ozbayoglu; Paco Vieira

    2000-10-30

    This is the first quarterly progress report for Year 2 of the ACTS project. It includes a review of progress made in Flow Loop development and research during the period of time between July 14, 2000 and September 30, 2000. This report presents information on the following specific tasks: (a) Progress in Advanced Cuttings Transport Facility design and development (Task 2), (b) Progress on research project (Task 8): ''Study of Flow of Synthetic Drilling Fluids Under Elevated Pressure and Temperature Conditions'', (c) Progress on research project (Task 6): ''Study of Cuttings Transport with Foam Under LPAT Conditions (Joint Project with TUDRP)'', (d) Progress on research project (Task 7): ''Study of Cuttings Transport with Aerated Muds Under LPAT Conditions (Joint Project with TUDRP)'', (e) Progress on research project (Task 9): ''Study of Foam Flow Behavior Under EPET Conditions'', (f) Initiate research on project (Task 10): ''Study of Cuttings Transport with Aerated Mud Under Elevated Pressure and Temperature Conditions'', (g) Progress on instrumentation tasks to measure: Cuttings concentration and distribution (Tasks 11), and Foam properties (Task 12), (h) Initiate a comprehensive safety review of all flow-loop components and operational procedures. Since the previous Task 1 has been completed, we will now designate this new task as: (Task 1S). (i) Activities towards technology transfer and developing contacts with Petroleum and service company members, and increasing the number of JIP members.

  16. Spin Transport Shingo Katsumoto

    E-Print Network [OSTI]

    Iye, Yasuhiro

    -1-5 Kashiwanoha, Kashiwa, Chiba 277-8581, Japan According to DARPA's definition, "Spintronics"[1] means "Spin Transport Electronics". The issue "Spin Trans- port" thus covers all the fields of spintronics and one devices. In semiconductor spintronics devices, we therefore utilize the differences in n, , m for up

  17. EPAct Transportation Regulatory Activities

    SciTech Connect (OSTI)

    2011-11-21

    The U.S. Department of Energy's (DOE) Vehicle Technologies Program manages several transportation regulatory activities established by the Energy Policy Act of 1992 (EPAct), as amended by the Energy Conservation Reauthorization Act of 1998, EPAct 2005, and the Energy Independence and Security Act of 2007 (EISA).

  18. Artificial oxygen transport protein

    DOE Patents [OSTI]

    Dutton, P. Leslie

    2014-09-30

    This invention provides heme-containing peptides capable of binding molecular oxygen at room temperature. These compounds may be useful in the absorption of molecular oxygen from molecular oxygen-containing atmospheres. Also included in the invention are methods for treating an oxygen transport deficiency in a mammal.

  19. Storing and transporting energy

    DOE Patents [OSTI]

    McClaine, Andrew W. (Lexington, MA); Brown, Kenneth (Reading, MA)

    2010-09-07

    Among other things, hydrogen is released from water at a first location using energy from a first energy source; the released hydrogen is stored in a metal hydride slurry; and the metal hydride slurry is transported to a second location remote from the first location.

  20. "Educating transportation professionals."

    E-Print Network [OSTI]

    Zhigilei, Leonid V.

    @virginia.edu http://cts.virginia.edu/Demetsky.htm Dept. of Civil and Environmental Engineering University of Virginia Charlottesville, VA 434.924.7464 Transportation Engineering & Management Research Our group works and Operations The mobility of freight is vital to the national economy. The growth in demand for freight

  1. Ionic (Proton) Transport Hydrogen

    E-Print Network [OSTI]

    environments - #12;Technology Options -- Ionic Transport Separation Systems Central, Semi-Central (coal/Semi-Central Systems Coal is the cheapest fuel, but requires the greatest pre-conditioning Clean-up of syngas requires Energy Systems ChevronTexaco SRI Consulting SAIC ChevronTexaco Technology Ventures #12;Performance

  2. Climate Change and Transportation

    E-Print Network [OSTI]

    Minnesota, University of

    1 Climate Change and Transportation Addressing Climate Change in the Absence of Federal Guidelines;6 WSDOT Efforts · Climate Change Team · Project Level GHG Approach · Planning Level GHG Approach · Alternative Fuels Corridor · Recent legislation and research #12;7 WSDOT Efforts: Climate Change Team

  3. Saturated Zone Colloid Transport

    SciTech Connect (OSTI)

    H. S. Viswanathan

    2004-10-07

    This scientific analysis provides retardation factors for colloids transporting in the saturated zone (SZ) and the unsaturated zone (UZ). These retardation factors represent the reversible chemical and physical filtration of colloids in the SZ. The value of the colloid retardation factor, R{sub col} is dependent on several factors, such as colloid size, colloid type, and geochemical conditions (e.g., pH, Eh, and ionic strength). These factors are folded into the distributions of R{sub col} that have been developed from field and experimental data collected under varying geochemical conditions with different colloid types and sizes. Attachment rate constants, k{sub att}, and detachment rate constants, k{sub det}, of colloids to the fracture surface have been measured for the fractured volcanics, and separate R{sub col} uncertainty distributions have been developed for attachment and detachment to clastic material and mineral grains in the alluvium. Radionuclides such as plutonium and americium sorb mostly (90 to 99 percent) irreversibly to colloids (BSC 2004 [DIRS 170025], Section 6.3.3.2). The colloid retardation factors developed in this analysis are needed to simulate the transport of radionuclides that are irreversibly sorbed onto colloids; this transport is discussed in the model report ''Site-Scale Saturated Zone Transport'' (BSC 2004 [DIRS 170036]). Although it is not exclusive to any particular radionuclide release scenario, this scientific analysis especially addresses those scenarios pertaining to evidence from waste-degradation experiments, which indicate that plutonium and americium may be irreversibly attached to colloids for the time scales of interest. A section of this report will also discuss the validity of using microspheres as analogs to colloids in some of the lab and field experiments used to obtain the colloid retardation factors. In addition, a small fraction of colloids travels with the groundwater without any significant retardation. Radionuclides irreversibly sorbed onto this fraction of colloids also transport without retardation. The transport times for these radionuclides will be the same as those for nonsorbing radionuclides. The fraction of nonretarding colloids developed in this analysis report is used in the abstraction of SZ and UZ transport models in support of the total system performance assessment (TSPA) for the license application (LA). This analysis report uses input from two Yucca Mountain Project (YMP) analysis reports. This analysis uses the assumption from ''Waste Form and In-Drift Colloids-Associated Radionuclide Concentrations: Abstraction and Summary'' that plutonium and americium are irreversibly sorbed to colloids generated by the waste degradation processes (BSC 2004 [DIRS 170025]). In addition, interpretations from RELAP analyses from ''Saturated Zone In-Situ Testing'' (BSC 2004 [DIRS 170010]) are used to develop the retardation factor distributions in this analysis.

  4. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a user of that drug (e.g. it produces a positive result with probability .98 in the case that the tested individual uses the drug) and 90% accurate in the case of a non

  5. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug .98 in the case that the tested individual uses the drug) and 90% accurate in the case of a non it is known that 10% of the entire population uses this drug. You test someone and the test is positive. What

  6. A Transport Synthetic Acceleration method for transport iterations 

    E-Print Network [OSTI]

    Ramone, Gilles Lionel

    1996-01-01

    We present a family of Transport Synthetic Acceleration (TSA) methods to iteratively solve within-group scattering problems. A single iteration in these schemes consists of a transport sweep followed by a low-order calculation ...

  7. 35 Alternative Transportation Fuels in California ALTERNATIVE TRANSPORTATION

    E-Print Network [OSTI]

    potential means for diversifying an energy resource base for the transportation sector. Largely as a result, there is a potential for the entrance of an estimated one million alternative fuel vehicles (AFVs) into the California35 Alternative Transportation Fuels in California Chapter 4 ALTERNATIVE TRANSPORTATION FUELS

  8. To cite this document: Fares, Fares and Escrig, Benot and Boucheret, Marie-Laure and Calmettes, Thibaud

    E-Print Network [OSTI]

    Mailhes, Corinne

    : Wireless Telecommunications Symposium (WTS), 2012, 18-20 Apr 2012, London, UK. Open Archive Toulouse: http://oatao.univ-toulouse.fr/ Eprints ID: 5898 Official URL: http://dx.doi.org/10.1109/WTS.2012

  9. Integrated transportation system design optimization

    E-Print Network [OSTI]

    Taylor, Christine P. (Christine Pia), 1979-

    2007-01-01

    Traditionally, the design of a transportation system has focused on either the vehicle design or the network flow, assuming the other as given. However, to define a system level architecture for a transportation system, ...

  10. Emerging pathogens: Dynamics, mutation and drug resistance

    SciTech Connect (OSTI)

    Perelson, A.S.; Goldstein, B.; Korber, B.T. [and others

    1997-10-01

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objectives of this project were to develop models of the spread of pathogens, such as HIV-1 and influenza, in humans, and then to use the models to address the possibility of designing appropriate drug therapies that may limit the ability of the pathogen to escape treatment by mutating into a drug resistant form. We have developed a model of drug-resistance to amantidine and rimantadine, the two major antiviral drugs used to treat influenza, and have used the model to suggest treatment strategies during an epidemic.

  11. Automated High Throughput Drug Target Crystallography

    SciTech Connect (OSTI)

    Rupp, B

    2005-02-18

    The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.

  12. Analysis of Assembly Bill 310: Prescription Drugs

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01

    drugs related to infertility treatment (for those plans thatloss treatments; infertility treatments; smoking cessationfor the treatment of sexual dysfunction and infertility). In

  13. Transport Properties of Bilayer Graphene Nanoribbons

    E-Print Network [OSTI]

    Wang, Minsheng

    2013-01-01

    Electrical spin injection and transport in germanium”. Phys.P. , Temperature- Dependent Transport in Suspended Graphene.Y. M. , Quantum Transport: Introduction to Nanoscience.

  14. Contaminant Transport in the Southern California Bight

    E-Print Network [OSTI]

    Idica, Eileen Y.

    2010-01-01

    1987). The California Current transports Pacific Subarctic1987). The California Current transports Pacific Subarcticthe dynamics and transport of Southern California stormwater

  15. Computational Method for Drug Target Search and Application in Drug Discovery

    E-Print Network [OSTI]

    Chen, Yuzong

    Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug. A protein structure database is searched to find proteins to which a drug can bind ...

  16. Transforming California's Freight Transport System

    E-Print Network [OSTI]

    California at Davis, University of

    Transforming California's Freight Transport System Policy Forum on the Role of Freight Transport in Achieving Clean Air, Climate Goals, Economic Growth and Healthy Communities in California Jack Kitowski April 19, 2013 1 #12;Freight Impacts at Many Levels 2 #12;Freight Transport Today: Contribution

  17. Parallel Transports in Webs

    E-Print Network [OSTI]

    Christian Fleischhack

    2003-07-17

    For connected reductive linear algebraic structure groups it is proven that every web is holonomically isolated. The possible tuples of parallel transports in a web form a Lie subgroup of the corresponding power of the structure group. This Lie subgroup is explicitly calculated and turns out to be independent of the chosen local trivializations. Moreover, explicit necessary and sufficient criteria for the holonomical independence of webs are derived. The results above can even be sharpened: Given an arbitrary neighbourhood of the base points of a web, then this neighbourhood contains some segments of the web whose parameter intervals coincide, but do not include 0 (that corresponds to the base points of the web), and whose parallel transports already form the same Lie subgroup as those of the full web do.

  18. Fuel cell water transport

    DOE Patents [OSTI]

    Vanderborgh, Nicholas E. (Los Alamos, NM); Hedstrom, James C. (Los Alamos, NM)

    1990-01-01

    The moisture content and temperature of hydrogen and oxygen gases is regulated throughout traverse of the gases in a fuel cell incorporating a solid polymer membrane. At least one of the gases traverses a first flow field adjacent the solid polymer membrane, where chemical reactions occur to generate an electrical current. A second flow field is located sequential with the first flow field and incorporates a membrane for effective water transport. A control fluid is then circulated adjacent the second membrane on the face opposite the fuel cell gas wherein moisture is either transported from the control fluid to humidify a fuel gas, e.g., hydrogen, or to the control fluid to prevent excess water buildup in the oxidizer gas, e.g., oxygen. Evaporation of water into the control gas and the control gas temperature act to control the fuel cell gas temperatures throughout the traverse of the fuel cell by the gases.

  19. Rail transportation update

    SciTech Connect (OSTI)

    Buchsbaum, L.

    2009-01-15

    Record western coal shipments and lucrative export traffic lead America's railroad to their fourth most profitable year in history. But with the coal boom going bust, higher rates, and a new administration and congress, what sort of transportation year can coal mines and shippers expect in 2009? The article gives the opinions of company executives and discusses findings of the recent so-called Christenson Report which investigated growing railroad market power. 1 ref., 1 fig.

  20. Multiscale thermal transport.

    SciTech Connect (OSTI)

    Graham, Samuel Jr. (; .); Wong, C. C.; Piekos, Edward Stanley

    2004-02-01

    A concurrent computational and experimental investigation of thermal transport is performed with the goal of improving understanding of, and predictive capability for, thermal transport in microdevices. The computational component involves Monte Carlo simulation of phonon transport. In these simulations, all acoustic modes are included and their properties are drawn from a realistic dispersion relation. Phonon-phonon and phonon-boundary scattering events are treated independently. A new set of phonon-phonon scattering coefficients are proposed that reflect the elimination of assumptions present in earlier analytical work from the simulation. The experimental component involves steady-state measurement of thermal conductivity on silicon films as thin as 340nm at a range of temperatures. Agreement between the experiment and simulation on single-crystal silicon thin films is excellent, Agreement for polycrystalline films is promising, but significant work remains to be done before predictions can be made confidently. Knowledge gained from these efforts was used to construct improved semiclassical models with the goal of representing microscale effects in existing macroscale codes in a computationally efficient manner.

  1. Transportation of medical isotopes

    SciTech Connect (OSTI)

    Nielsen, D.L.

    1997-11-19

    A Draft Technical Information Document (HNF-1855) is being prepared to evaluate proposed interim tritium and medical isotope production at the Fast Flux Test Facility (FFTF). This assessment examines the potential health and safety impacts of transportation operations associated with the production of medical isotopes. Incident-free and accidental impacts are assessed using bounding source terms for the shipment of nonradiological target materials to the Hanford Site, the shipment of irradiated targets from the FFTF to the 325 Building, and the shipment of medical isotope products from the 325 Building to medical distributors. The health and safety consequences to workers and the public from the incident-free transportation of targets and isotope products would be within acceptable levels. For transportation accidents, risks to works and the public also would be within acceptable levels. This assessment is based on best information available at this time. As the medical isotope program matures, this analysis will be revised, if necessary, to support development of a final revision to the Technical Information Document.

  2. Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs

    E-Print Network [OSTI]

    Liu, Mei; Wu, Yonghui; Chen, Yukun; Sun, Jingchun; Zhao, Zhongming; Chen, Xue-wen; Matheny, Michael Edwin; Xu, Hua

    2012-06-19

    Abstract Objective Adverse drug reaction (ADR) is one of the major causes of failure in drug development. Severe ADRs that go undetected until the post-marketing phase of a drug often lead to patient morbidity. Accurate prediction of potential ADRs...

  3. Drug Testing Notification Form RV 2 May 22, 2013 DRUG TESTING NOTIFICATION FORM

    E-Print Network [OSTI]

    Drug Testing Notification Form RV 2 May 22, 2013 DRUG TESTING NOTIFICATION FORM Section 1: Employer testing collector. You are required to undergo urine drug testing as a condition of hiring. You must have of Collection: ___________________________ Date and time of Test* * For testing out side of Louisiana testing

  4. Transportation Energy Futures Analysis Snapshot

    Broader source: Energy.gov [DOE]

    Transportation currently accounts for 71% of total U.S. petroleum use and 33% of the nation's total carbon emissions. The TEF project explores how combining multiple strategies could reduce GHG emissions and petroleum use by 80%. Researchers examined four key areas – lightduty vehicles, non-light-duty vehicles, fuels, and transportation demand – in the context of the marketplace, consumer behavior, industry capabilities, technology and the energy and transportation infrastructure. The TEF reports support DOE long-term planning. The reports provide analysis to inform decisions about transportation energy research investments, as well as the role of advanced transportation energy technologies and systems in the development of new physical, strategic, and policy alternatives.

  5. ADVANCED CUTTINGS TRANSPORT STUDY

    SciTech Connect (OSTI)

    Stefan Miska; Troy Reed; Ergun Kuru

    2004-09-30

    The Advanced Cuttings Transport Study (ACTS) was a 5-year JIP project undertaken at the University of Tulsa (TU). The project was sponsored by the U.S. Department of Energy (DOE) and JIP member companies. The objectives of the project were: (1) to develop and construct a new research facility that would allow three-phase (gas, liquid and cuttings) flow experiments under ambient and EPET (elevated pressure and temperature) conditions, and at different angle of inclinations and drill pipe rotation speeds; (2) to conduct experiments and develop a data base for the industry and academia; and (3) to develop mechanistic models for optimization of drilling hydraulics and cuttings transport. This project consisted of research studies, flow loop construction and instrumentation development. Following a one-year period for basic flow loop construction, a proposal was submitted by TU to the DOE for a five-year project that was organized in such a manner as to provide a logical progression of research experiments as well as additions to the basic flow loop. The flow loop additions and improvements included: (1) elevated temperature capability; (2) two-phase (gas and liquid, foam etc.) capability; (3) cuttings injection and removal system; (4) drill pipe rotation system; and (5) drilling section elevation system. In parallel with the flow loop construction, hydraulics and cuttings transport studies were preformed using drilling foams and aerated muds. In addition, hydraulics and rheology of synthetic drilling fluids were investigated. The studies were performed under ambient and EPET conditions. The effects of temperature and pressure on the hydraulics and cuttings transport were investigated. Mechanistic models were developed to predict frictional pressure loss and cuttings transport in horizontal and near-horizontal configurations. Model predictions were compared with the measured data. Predominantly, model predictions show satisfactory agreements with the measured data. As a part of this project, instrumentation was developed to monitor cuttings beds and characterize foams in the flow loop. An ultrasonic-based monitoring system was developed to measure cuttings bed thickness in the flow loop. Data acquisition software controls the system and processes the data. Two foam generating devices were designed and developed to produce foams with specified quality and texture. The devices are equipped with a bubble recognition system and an in-line viscometer to measure bubble size distribution and foam rheology, respectively. The 5-year project is completed. Future research activities will be under the umbrella of Tulsa University Drilling Research Projects. Currently the flow loop is being used for testing cuttings transport capacity of aqueous and polymer-based foams under elevated pressure and temperature conditions. Subsequently, the effect of viscous sweeps on cuttings transport under elevated pressure and temperature conditions will be investigated using the flow loop. Other projects will follow now that the ''steady state'' phase of the project has been achieved.

  6. POLICY STATEMENT ON DRUG-FREE CAMPUS*

    E-Print Network [OSTI]

    Karsai, Istvan

    11 POLICY STATEMENT ON DRUG-FREE CAMPUS* It is the policy of ETSU that the unlawful manufacture, distribution, possession, use of alcohol and illicit drugs on the ETSU campus, in the workplace (on or off campus), on property owned or controlled by ETSU, or as part of any activity of ETSU is strictly

  7. Antiplatelet and Anticoagulant Drugs in Interventional Radiology

    SciTech Connect (OSTI)

    Altenburg, Alexander; Haage, Patrick, E-mail: patrick.haage@helios-kliniken.de [University Hospital Witten/Herdecke, Department of Diagnostic and Interventional Radiology, HELIOS Klinikum Wuppertal (Germany)

    2012-02-15

    In treating peripheral arterial disease, a profound knowledge of antiplatelet and anticoagulative drug therapy is helpful to assure a positive clinical outcome and to anticipate and avoid complications. Side effects and drug interactions may have fatal consequences for the patient, so interventionalists should be aware of these risks and able to control them. Aspirin remains the first-line agent for antiplatelet monotherapy, with clopidogrel added where dual antiplatelet therapy is required. In case of suspected antiplatelet drug resistance, the dose of clopidogrel may be doubled; prasugrel or ticagrelor may be used alternatively. Glycoprotein IIb/IIIa inhibitors (abciximab or eptifibatide) may help in cases of hypercoagulability or acute embolic complications. Desmopressin, tranexamic acid, or platelet infusions may be used to decrease antiplatelet drug effects in case of bleeding. Intraprocedurally, anticoagulant therapy treatment with unfractionated heparin (UFH) still is the means of choice, although low molecular-weight heparins (LMWH) are suitable, particularly for postinterventional treatment. Adaption of LMWH dose is often required in renal insufficiency, which is frequently found in elderly patients. Protamine sulphate is an effective antagonist for UFH; however, this effect is less for LMWH. Newer antithrombotic drugs, such as direct thrombin inhibitors or factor X inhibitors, have limited importance in periprocedural treatment, with the exception of treating patients with heparin-induced thrombocytopenia (HIT). Nevertheless, knowing pharmacologic properties of the newer drugs facilitate correct bridging of patients treated with such drugs. This article provides a comprehensive overview of antiplatelet and anticoagulant drugs for use before, during, and after interventional radiological procedures.

  8. Pricing in the Market for Anticancer Drugs

    E-Print Network [OSTI]

    Howard, David H.

    In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab— brand name Yervoy—at $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

  9. Transport optimization in stellaratorsa... H. E. Mynickb

    E-Print Network [OSTI]

    Mynick, Harry E.

    Transport optimization in stellaratorsa... H. E. Mynickb Plasma Physics Laboratory, Princeton transport in stellarators is presented. A primary deficiency of stellarators has been elevated transport this difficulty, developing a range of techniques for reducing transport, both neoclassical and, more recently

  10. Illegal Drugs Policy Swansea University and Students' Union

    E-Print Network [OSTI]

    Martin, Ralph R.

    Illegal Drugs Policy Swansea University and Students' Union #12;Illegal Drugs Policy for Swansea University and Students' Union Table of Contents Page Drugs Policy Statement 2 Drugs Policy 3 1. Introduction 2. Who is covered by the policy? 3. Aims of the policy 5. What do we mean by illegal drugs? 4

  11. Update on EM Transportation Program Activities

    Office of Environmental Management (EM)

    Organizations * DOE Orders, Policy, Guidance Transportation Risk Reduction * Motor Carrier Evaluations * Physical Protection * Transportation Compliance Reviews * Safety...

  12. Supertruck - Improving Transportation Efficiency through Integrated...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Improving Transportation Efficiency through Integrated Vehicle, Engine and Powertrain Research Supertruck - Improving Transportation Efficiency through Integrated Vehicle, Engine...

  13. Department of Transportation Pipeline and Hazardous Materials...

    Office of Environmental Management (EM)

    Transportation Pipeline and Hazardous Materials Safety Administration Activities Department of Transportation Pipeline and Hazardous Materials Safety Administration Activities...

  14. Africa's Transport Infrastructure Mainstreaming Maintenance and...

    Open Energy Info (EERE)

    Africa's Transport Infrastructure Mainstreaming Maintenance and Management Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Africa's Transport Infrastructure...

  15. Transportation and Stationary Power Integration Workshop Session...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Transportation and Stationary Power Integration Workshop Agenda, October 27, 2008, Phoenix, Arizonia Transportation and Stationary Power Integration: Workshop Proceedings...

  16. Enhancing Transportation Energy Security through Advanced Combustion...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Transportation Energy Security through Advanced Combustion and Fuels Technologies Enhancing Transportation Energy Security through Advanced Combustion and Fuels Technologies 2005...

  17. ADVANCED CUTTINGS TRANSPORT STUDY

    SciTech Connect (OSTI)

    Ergun Kuru; Stefan Miska; Nicholas Takach; Kaveh Ashenayi; Gerald Kane; Mark Pickell; Len Volk; Mike Volk; Barkim Demirdal; Affonso Lourenco; Evren Ozbayoglu; Paco Vieira; Neelima Godugu

    2000-07-30

    ACTS flow loop is now operational under elevated pressure and temperature. Currently, experiments with synthetic based drilling fluids under pressure and temperature are being conducted. Based on the analysis of Fann 70 data, empirical correlations defining the shear stress as a function of temperature, pressure and the shear rate have been developed for Petrobras synthetic drilling fluids. PVT equipment has been modified for testing Synthetic oil base drilling fluids. PVT tests with Petrobras Synthetic base mud have been conducted and results are being analyzed Foam flow experiments have been conducted and the analysis of the data has been carried out to characterize the rheology of the foam. Comparison of pressure loss prediction from the available foam hydraulic models and the test results has been made. Cuttings transport experiments in horizontal annulus section have been conducted using air, water and cuttings. Currently, cuttings transport tests in inclined test section are being conducted. Foam PVT analysis tests have been conducted. Foam stability experiments have also been conducted. Effects of salt and oil concentration on the foam stability have been investigated. Design of ACTS flow loop modification for foam and aerated mud flow has been completed. A flow loop operation procedure for conducting foam flow experiments under EPET conditions has been prepared Design of the lab-scale flow loop for dynamic foam characterization and cuttings monitoring instrumentation tests has been completed. The construction of the test loop is underway. As part of the technology transport efforts, Advisory Board Meeting with ACTS-JIP industry members has been organized on May 13, 2000.

  18. ADVANCED CUTTINGS TRANSPORT STUDY

    SciTech Connect (OSTI)

    Stefan Miska; Nicholas Takach; Kaveh Ashenayi; Mengjiao Yu; Ramadan Ahmed; Mark Pickell; Len Volk; Lei Zhou; Zhu Chen; Aimee Washington; Crystal Redden

    2003-09-30

    The Quarter began with installing the new drill pipe, hooking up the new hydraulic power unit, completing the pipe rotation system (Task 4 has been completed), and making the SWACO choke operational. Detailed design and procurement work is proceeding on a system to elevate the drill-string section. The prototype Foam Generator Cell has been completed by Temco and delivered. Work is currently underway to calibrate the system. Literature review and preliminary model development for cuttings transportation with polymer foam under EPET conditions are in progress. Preparations for preliminary cuttings transport experiments with polymer foam have been completed. Two nuclear densitometers were re-calibrated. Drill pipe rotation system was tested up to 250 RPM. Water flow tests were conducted while rotating the drill pipe up to 100 RPM. The accuracy of weight measurements for cuttings in the annulus was evaluated. Additional modifications of the cuttings collection system are being considered in order to obtain the desired accurate measurement of cuttings weight in the annular test section. Cutting transport experiments with aerated fluids are being conducted at EPET, and analyses of the collected data are in progress. The printed circuit board is functioning with acceptable noise level to measure cuttings concentration at static condition using ultrasonic method. We were able to conduct several tests using a standard low pass filter to eliminate high frequency noise. We tested to verify that we can distinguish between different depths of sand in a static bed of sand. We tested with water, air and a mix of the two mediums. Major modifications to the DTF have almost been completed. A stop-flow cell is being designed for the DTF, the ACTF and Foam Generator/Viscometer which will allow us to capture bubble images without the need for ultra fast shutter speeds or microsecond flash system.

  19. Resolving the mystery of transport within internal transport barriers

    SciTech Connect (OSTI)

    Staebler, G. M.; Belli, E. A.; Candy, J.; Waltz, R. E.; Greenfield, C. M.; Lao, L. L.; Smith, S. P.; Kinsey, J. E.; Grierson, B. A.; Chrystal, C.

    2014-05-15

    The Trapped Gyro-Landau Fluid (TGLF) quasi-linear model [G. M. Staebler, et al., Phys. Plasmas 12, 102508 (2005)], which is calibrated to nonlinear gyrokinetic turbulence simulations, is now able to predict the electron density, electron and ion temperatures, and ion toroidal rotation simultaneously for internal transport barrier (ITB) discharges. This is a strong validation of gyrokinetic theory of ITBs, requiring multiple instabilities responsible for transport in different channels at different scales. The mystery of transport inside the ITB is that momentum and particle transport is far above the predicted neoclassical levels in apparent contradiction with the expectation from the theory of suppression of turbulence by E×B velocity shear. The success of TGLF in predicting ITB transport is due to the inclusion of ion gyro-radius scale modes that become dominant at high E×B velocity shear and to improvements to TGLF that allow momentum transport from gyrokinetic turbulence to be faithfully modeled.

  20. Transportation | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservationBio-Inspired SolarAbout / Transforming Y-12Capacity-ForumTransportation

  1. Transportation | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION JEnvironmental Jump to:EA EISTJThin Film SolarTown ofTransportToolkit Prototype Jump

  2. Transportation Fuel Supply | NISAC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.WeekProducts >Transportation currently accounts for

  3. Transportation Representation | NISAC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.WeekProducts >Transportation currently

  4. Transportation and Parking

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.WeekProducts >Transportation

  5. Electron Heat Transport Measured

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submitKansas Nuclear ProfileMultiferroicAward |Electron CorrelationHeat Transport

  6. Sandia Energy - Transportation Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II)GeothermalFuel MagnetizationTransportation Energy Home Analysis Final

  7. Sandia Energy - Transportation Safety

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II)GeothermalFuel MagnetizationTransportation Energy Home

  8. Modeling Multiple Drugs on Lung Cancer and Normal Cells using Regression

    E-Print Network [OSTI]

    Chen, Michelle

    2013-01-01

    Drug Combination . . . . . . . . . . . . . . . .n 27 vii List of Tables Drug Concentration . . . . . . .Factorial Designs in Antiviral Drug Stud- ies. ” Quality and

  9. An implantable device for localized drug delivery and sensing

    E-Print Network [OSTI]

    Daniel, Karen D

    2009-01-01

    There are many potential clinical applications for localized drug delivery and sensing systems, such as cancer, vaccinations, pain management, and hormone therapy. Localized drug delivery systems reduce the amount of drug ...

  10. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print Tuesday, 23 June 2015 13:00 The cancer drug...

  11. Prescription Drug Monitoring Programs: Examining Limitations and Future Approaches

    E-Print Network [OSTI]

    Griggs, Christopher A.; Weiner, Scott G.; Feldman, James A.

    2015-01-01

    Li G, Brady JE, Lang B, et al. Prescription drug monitoringand drug overdose mortality. Inj Epidemiol. 2014;1:1-9.EM, Desai HA. Prescription drug monitoring programs and

  12. Drugs in Cinema: Separating the Myths from Reality

    E-Print Network [OSTI]

    Iannicelli, Paul

    2001-01-01

    Introduction: The Evolution of Drug Abuse in Americain HAND- BOOK OF DRUG CONTROL IN THE UNITED STATES (James A.See JOSEPH SPILLANE, MODERN DRUG, MODERN MENANCE 214 (1994).

  13. Optimizing Combination Therapies with Existing and Future CML Drugs

    E-Print Network [OSTI]

    Katouli, Allen A.; Komarova, Natalia L.

    2010-01-01

    kinase inhibitors. Nat Rev Drug Discov 3: 1001–10. 12.screen: high efficacy of drug combinations. Blood 108: 2332–Abl kinase domain mutations, drug resistance, and the road

  14. ELECTROCHEMICAL POWER FOR TRANSPORTATION

    SciTech Connect (OSTI)

    Cairns, Elton J.; Hietbrink, Earl H.

    1981-01-01

    This section includes some historical background of the rise and fall and subsequent rebirth of the electric vehicle; and a brief discussion of current transportation needs, and environmental and energy utilization issues that resulted in the renewed interest in applying electrochemical energy conversion technology to electric vehicle applications. Although energy utilization has evolved to be the most significant and important issue, the environmental issue will be discussed first in this section only because of its chronological occurrence. The next part of the chapter is a review of passenger and commercial electric vehicle technology with emphasis on vehicle design and demonstrated performance of vehicles with candidate power sources being developed. This is followed by a discussion of electrochemical power source requirements associated with future electric vehicles that can play a role in meeting modern transportation needs. The last part of the chapter includes first a discussion of how to identify candidate electrochemical systems that might be of interest in meeting electric vehicle power source requirements. This is then followed by a review of the current technological status of these systems and a discussion of the most significant problems that must be resolved before each candidate system can be a viable power source.

  15. ADVANCED CUTTINGS TRANSPORT STUDY

    SciTech Connect (OSTI)

    Troy Reed; Stefan Miska; Nicholas Takach; Kaveh Ashenayi; Mark Pickell; Len Volk; Mike Volk; Lei Zhou; Zhu Chen; Crystal Redden; Aimee Washington

    2003-07-30

    This Quarter has been divided between running experiments and the installation of the drill-pipe rotation system. In addition, valves and piping were relocated, and three viewports were installed. Detailed design work is proceeding on a system to elevate the drill-string section. Design of the first prototype version of a Foam Generator has been finalized, and fabrication is underway. This will be used to determine the relationship between surface roughness and ''slip'' of foams at solid boundaries. Additional cups and rotors are being machined with different surface roughness. Some experiments on cuttings transport with aerated fluids have been conducted at EPET. Theoretical modeling of cuttings transport with aerated fluids is proceeding. The development of theoretical models to predict frictional pressure losses of flowing foam is in progress. The new board design for instrumentation to measure cuttings concentration is now functioning with an acceptable noise level. The ultrasonic sensors are stable up to 190 F. Static tests with sand in an annulus indicate that the system is able to distinguish between different sand concentrations. Viscometer tests with foam, generated by the Dynamic Test Facility (DTF), are continuing.

  16. OXYGEN TRANSPORT CERAMIC MEMBRANES

    SciTech Connect (OSTI)

    Dr. Sukumar Bandopadhyay; Dr. Nagendra Nagabhushana

    2000-10-01

    This is the third quarterly report on oxygen Transport Ceramic Membranes. In the following, the report describes the progress made by our university partners in Tasks 1 through 6, experimental apparatus that was designed and built for various tasks of this project, thermodynamic calculations, where applicable and work planned for the future. (Task 1) Design, fabricate and evaluate ceramic to metal seals based on graded ceramic powder/metal braze joints. (Task 2) Evaluate the effect of defect configuration on ceramic membrane conductivity and long term chemical and structural stability. (Task 3) Determine materials mechanical properties under conditions of high temperatures and reactive atmospheres. (Task 4) Evaluate phase stability and thermal expansion of candidate perovskite membranes and develop techniques to support these materials on porous metal structures. (Task 5) Assess the microstructure of membrane materials to evaluate the effects of vacancy-impurity association, defect clusters, and vacancy-dopant association on the membrane performance and stability. (Task 6) Measure kinetics of oxygen uptake and transport in ceramic membrane materials under commercially relevant conditions using isotope labeling techniques.

  17. Transportation Statistics Annual Report 1997

    SciTech Connect (OSTI)

    Fenn, M.

    1997-01-01

    This document is the fourth Transportation Statistics Annual Report (TSAR) prepared by the Bureau of Transportation Statistics (BTS) for the President and Congress. As in previous years, it reports on the state of U.S. transportation system at two levels. First, in Part I, it provides a statistical and interpretive survey of the system—its physical characteristics, its economic attributes, aspects of its use and performance, and the scale and severity of unintended consequences of transportation, such as fatalities and injuries, oil import dependency, and environment impacts. Part I also explores the state of transportation statistics, and new needs of the rapidly changing world of transportation. Second, Part II of the report, as in prior years, explores in detail the performance of the U.S. transportation system from the perspective of desired social outcomes or strategic goals. This year, the performance aspect of transportation chosen for thematic treatment is “Mobility and Access,” which complements past TSAR theme sections on “The Economic Performance of Transportation” (1995) and “Transportation and the Environment” (1996). Mobility and access are at the heart of the transportation system’s performance from the user’s perspective. In what ways and to what extent does the geographic freedom provided by transportation enhance personal fulfillment of the nation’s residents and contribute to economic advancement of people and businesses? This broad question underlies many of the topics examined in Part II: What is the current level of personal mobility in the United States, and how does it vary by sex, age, income level, urban or rural location, and over time? What factors explain variations? Has transportation helped improve people’s access to work, shopping, recreational facilities, and medical services, and in what ways and in what locations? How have barriers, such as age, disabilities, or lack of an automobile, affected these accessibility patterns? How are commodity flows and transportation services responding to global competition, deregulation, economic restructuring, and new information technologies? How do U.S. patterns of personal mobility and freight movement compare with other advanced industrialized countries, formerly centrally planned economies, and major newly industrializing countries? Finally, how is the rapid adoption of new information technologies influencing the patterns of transportation demand and the supply of new transportation services? Indeed, how are information technologies affecting the nature and organization of transportation services used by individuals and firms?

  18. Nanoengineered membranes for controlled transport

    DOE Patents [OSTI]

    Doktycz, Mitchel J. (Oak Ridge, TN) [Oak Ridge, TN; Simpson, Michael L. (Knoxville, TN) [Knoxville, TN; McKnight, Timothy E. (Greenback, TN) [Greenback, TN; Melechko, Anatoli V. (Oak Ridge, TN) [Oak Ridge, TN; Lowndes, Douglas H. (Knoxville, TN) [Knoxville, TN; Guillorn, Michael A. (Knoxville, TN) [Knoxville, TN; Merkulov, Vladimir I. (Oak Ridge, TN) [Oak Ridge, TN

    2010-01-05

    A nanoengineered membrane for controlling material transport (e.g., molecular transport) is disclosed. The membrane includes a substrate, a cover definining a material transport channel between the substrate and the cover, and a plurality of fibers positioned in the channel and connected to an extending away from a surface of the substrate. The fibers are aligned perpendicular to the surface of the substrate, and have a width of 100 nanometers or less. The diffusion limits for material transport are controlled by the separation of the fibers. In one embodiment, chemical derivitization of carbon fibers may be undertaken to further affect the diffusion limits or affect selective permeability or facilitated transport. For example, a coating can be applied to at least a portion of the fibers. In another embodiment, individually addressable carbon nanofibers can be integrated with the membrane to provide an electrical driving force for material transport.

  19. Resistance proof, folding-inhibitor drugs

    E-Print Network [OSTI]

    R. Broglia; G. Tiana; R. Berera

    2002-10-09

    Conventional drugs work, as a rule, by inhibiting the enzymatic activity of specific proteins, capping their active site. In this paper we present a model of non- conventional drug design based on the inhibiting effects small peptides obtained from segments of the protein itself have on the folding ability of the system. Such peptides attach to the newly expressed (unfolded) protein and inhibit its folding, inhibition which cannot be avoided but through mutations which in any case denaturate the enzyme. These peptides, or their mimetic molecules, can be used as effective alternative drugs to those already available, displaying the advantage of not suffering from the upraise of resistence.

  20. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01

    International Journal of Drug Policy 10: 319-28. Zinberg,Norman E. 1984. Drug, Set, and Setting: The Basis forand Mirrors: The War on Drugs and the Politics of Failure.

  1. Flow cytometry aids basic cell biology research and drug discovery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Life Technologies Corporation and LANL have...

  2. Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug

    E-Print Network [OSTI]

    Hill, Wendell T.

    Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug's Nanotechnology Center are creating novel tools and developing new methods for crucial research areas of drug

  3. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein...

  4. Transportation and Greenhouse Gas Mitigation

    E-Print Network [OSTI]

    Lutsey, Nicholas P.; Sperling, Dan

    2008-01-01

    Summary of transportation greenhouse gas mitigation optionsof alternative fuels. Low greenhouse gas fuels Mixing ofMAC) refrigerant replacement. Greenhouse gas budgets for

  5. Heat transport within the Earth

    E-Print Network [OSTI]

    Herndon, J Marvin

    2011-01-01

    Numerous attempts have been made to interpret Earth's dynamic processes based upon heat transport concepts derived from ordinary experience. But, ordinary experience can be misleading, especially when underlain by false assumptions. Geodynamic considerations traditionally have embraced three modes of heat transport: conduction, convection, and radiation. Recently, I introduced a fourth, "mantle decompression thermal tsunami" that, I submit, is responsible for emplacing heat at the base of the Earth's crust. Here, I review thermal transport within the Earth and speculate that there might be a fifth mode: "heat channeling", involving heat transport from the core to "hot-spots" such as those that power the Hawaiian Islands and Iceland.

  6. Transportation Projects | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    share of petroleum use, carbon dioxide (a primary greenhouse gas) emissions, and air pollution, advances in fuel cell power systems for transportation could substantially improve...

  7. Transport Properties for Combustion Modeling

    E-Print Network [OSTI]

    Brown, N.J.

    2010-01-01

    a critical role in combustion processes just as chemicalparameters are essential for combustion modeling; molecularwith Application to Combustion. Transport Theor Stat 2003;

  8. TRANSPORTATION TOMORROW SURVEY DATA EXPANSION

    E-Print Network [OSTI]

    Toronto, University of

    in Transportation August 2007 #12;Table of Contents 1. Introduction and trip data associated with the households in that geographic area. The UTM coordinates belonging to each

  9. Alternative Transportation Technologies: Hydrogen, Biofuels,...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen, Biofuels, Advanced Efficiency, and Plug-in Hybrid Electric Vehicles Alternative Transportation Technologies: Hydrogen, Biofuels, Advanced Efficiency, and Plug-in...

  10. Transportation and Greenhouse Gas Mitigation

    E-Print Network [OSTI]

    Lutsey, Nicholas P.; Sperling, Dan

    2008-01-01

    thereby contributing to energy security. Most also reducesuch as improved energy security, many transport GHGincluding energy cost savings, oil security, and pollution

  11. Institute of Transport Studies PSU Transportation Seminar, 21 May 2010

    E-Print Network [OSTI]

    Bertini, Robert L.

    of Electric Bicycles Assoc. Prof. Geoff Rose Director, ITS (Monash) Transport Theme Leader, Monash expand the role of the bicycle in the context of urban transportation · This seminar examines electric Battery technology · Sealed lead acid (SLA) ­ Well understood and cheapest ­ Heavy ­ Modest life · Nickel

  12. Computational model of local intravascular drug delivery

    E-Print Network [OSTI]

    Balakrishnan, Brinda

    2007-01-01

    Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

  13. Transdermal drug delivery by localized intervention

    E-Print Network [OSTI]

    Weaver, James C.

    Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

  14. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01

    Drugs (ESSPAOD). 2003. The ESPAD Report 2003: Alcohol andModintryckoffset. http://www.espad.org/documents/Espad/ESPAD_reports/The_2003_ESPAD_report.pdf. Fainaru, Steve, and

  15. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01

    Throwing Away the Key or the Taxpayer’s Money? Santa Monica,sell these drugs has cost taxpayers billions of dollars eachdiffusely and the individual taxpayer cannot easily measure

  16. NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM

    E-Print Network [OSTI]

    Hart, Steven N.

    2011-02-22

    Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

  17. Climate and Transportation Solutions: Findings from the 2009 Asilomar Conference on Transportation and Energy Policy

    E-Print Network [OSTI]

    Sperling, Daniel; Cannon, James S.

    2010-01-01

    on Transportation, Energy and Policy convened in 1988. Oilon Transportation, Energy and Policy has been held at theon Transportation, Energy and Policy in July 2009 was the

  18. Climate and Transportation Solutions: Findings from the 2009 Asilomar Conference on Transportation and Energy Policy

    E-Print Network [OSTI]

    Sperling, Daniel; Cannon, James S.

    2010-01-01

    cials (AASHTO), Transport Canada, the California DepartmentA case study of California. ” Transport. Res. Part D. West,smaller transport-related carbon footprint than California,

  19. Climate and Transportation Solutions: Findings from the 2009 Asilomar Conference on Transportation and Energy Policy

    E-Print Network [OSTI]

    Sperling, Daniel; Cannon, James S.

    2010-01-01

    California Department of Transportation, the California EnergyCalifornia Energy Commission Climate and TransportationTransportation and Energy Policy, at Paci?c Grove, California.

  20. Transport in holographic superfluids

    E-Print Network [OSTI]

    Christopher P. Herzog; Nir Lisker; Piotr Surowka; Amos Yarom

    2011-01-17

    We construct a slowly varying space-time dependent holographic superfluid and compute its transport coefficients. Our solution is presented as a series expansion in inverse powers of the charge of the order parameter. We find that the shear viscosity associated with the motion of the condensate vanishes. The diffusion coefficient of the superfluid is continuous across the phase transition while its third bulk viscosity is found to diverge at the critical temperature. As was previously shown, the ratio of the shear viscosity of the normal component to the entropy density is 1/(4 pi). As a consequence of our analysis we obtain an analytic expression for the backreacted metric near the phase transition for a particular type of holographic superfluid.

  1. Heat transport system

    DOE Patents [OSTI]

    Harkness, Samuel D. (McMurray, PA)

    1982-01-01

    A falling bed of ceramic particles receives neutron irradiation from a neutron-producing plasma and thereby transports energy as heat from the plasma to a heat exchange location where the ceramic particles are cooled by a gas flow. The cooled ceramic particles are elevated to a location from which they may again pass by gravity through the region where they are exposed to neutron radiation. Ceramic particles of alumina, magnesia, silica and combinations of these materials are contemplated as high-temperature materials that will accept energy from neutron irradiation. Separate containers of material incorporating lithium are exposed to the neutron flux for the breeding of tritium that may subsequently be used in neutron-producing reactions. The falling bed of ceramic particles includes velocity partitioning between compartments near to the neutron-producing plasma and compartments away from the plasma to moderate the maximum temperature in the bed.

  2. OXYGEN TRANSPORT CERAMIC MEMBRANES

    SciTech Connect (OSTI)

    Dr. Sukumar Bandopadhyay; Dr. Nagendra Nagabhushana

    2003-01-01

    In the present quarter, experiments are presented on ceramic/metal interactions of Zirconia/Ni-B-Si system and with a thin Ti coating deposited on zirconia surface. Processing of perovskites of LSC, LSF and LSCF composition for evaluation of mechanical properties as a function of environment are begun. The studies are to be in parallel with LSFCO composition to characterize the segregation of cations and slow crack growth in environmental conditions. La{sub 1-x}Sr{sub x}FeO{sub 3-d} has also been characterized for paramagnetic ordering at room temperature and the evolution of magnetic moments as a function of temperature are investigated. Investigation on the thermodynamic properties of the membrane materials are continued to develop a complete model for the membrane transport.

  3. Hydrogen transport membranes

    DOE Patents [OSTI]

    Mundschau, Michael V.

    2005-05-31

    Composite hydrogen transport membranes, which are used for extraction of hydrogen from gas mixtures are provided. Methods are described for supporting metals and metal alloys which have high hydrogen permeability, but which are either too thin to be self supporting, too weak to resist differential pressures across the membrane, or which become embrittled by hydrogen. Support materials are chosen to be lattice matched to the metals and metal alloys. Preferred metals with high permeability for hydrogen include vanadium, niobium, tantalum, zirconium, palladium, and alloys thereof. Hydrogen-permeable membranes include those in which the pores of a porous support matrix are blocked by hydrogen-permeable metals and metal alloys, those in which the pores of a porous metal matrix are blocked with materials which make the membrane impervious to gases other than hydrogen, and cermets fabricated by sintering powders of metals with powders of lattice-matched ceramic.

  4. Transportation System Concept of Operations

    SciTech Connect (OSTI)

    N. Slater-Thompson

    2006-08-16

    The Nuclear Waste Policy Act of 1982 (NWPA), as amended, authorized the DOE to develop and manage a Federal system for the disposal of SNF and HLW. OCRWM was created to manage acceptance and disposal of SNF and HLW in a manner that protects public health, safety, and the environment; enhances national and energy security; and merits public confidence. This responsibility includes managing the transportation of SNF and HLW from origin sites to the Repository for disposal. The Transportation System Concept of Operations is the core high-level OCRWM document written to describe the Transportation System integrated design and present the vision, mission, and goals for Transportation System operations. By defining the functions, processes, and critical interfaces of this system early in the system development phase, programmatic risks are minimized, system costs are contained, and system operations are better managed, safer, and more secure. This document also facilitates discussions and understanding among parties responsible for the design, development, and operation of the Transportation System. Such understanding is important for the timely development of system requirements and identification of system interfaces. Information provided in the Transportation System Concept of Operations includes: the functions and key components of the Transportation System; system component interactions; flows of information within the system; the general operating sequences; and the internal and external factors affecting transportation operations. The Transportation System Concept of Operations reflects OCRWM's overall waste management system policies and mission objectives, and as such provides a description of the preferred state of system operation. The description of general Transportation System operating functions in the Transportation System Concept of Operations is the first step in the OCRWM systems engineering process, establishing the starting point for the lower level descriptions. of subsystems and components, and the Transportation System Requirements Document. Other program and system documents, plans, instructions, and detailed designs will be consistent with and informed by the Transportation System Concept of Operations. The Transportation System Concept of Operations is a living document, enduring throughout the OCRWM systems engineering lifecycle. It will undergo formal approval and controlled revisions as appropriate while the Transportation System matures. Revisions will take into account new policy decisions, new information available through system modeling, engineering investigations, technical analyses and tests, and the introduction of new technologies that can demonstrably improve system performance.

  5. Radioactive Material Transportation Practices Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-06-04

    This Manual establishes standard transportation practices for the Department of Energy, including National Nuclear Security Administration to use in planning and executing offsite shipments of radioactive materials and waste. The revision reflects ongoing collaboration of DOE and outside organizations on the transportation of radioactive material and waste. Supersedes DOE M 460.2-1.

  6. Charge-based transport and drug delivery into cartilage for localized treatment of degenerative joint diseases

    E-Print Network [OSTI]

    Bajpayee, Ambika Goel

    2015-01-01

    Traumatic joint injuries significantly increase synovial fluid levels of pro-inflammatory cytokines that can initiate cartilage degeneration leading to osteoarthritis (OA). Articular cartilage is a highly negatively charged, ...

  7. Tri-partite complex for axonal transport drug delivery achieves pharmacological effect

    E-Print Network [OSTI]

    Filler, Aaron G.; Whiteside, Garth T.; Bacon, Mark; Frederickson, Martyn; Howe, Franklyn A.; Rabinowitz, Miri D.; Sokoloff, Alan J.; Deacon, Terrence W.; Abell, Chris; Munglani, Raj; Griffiths, John R.; Bell, B. Anthony; Lever, Andrew M. L.

    2010-01-20

    be large when compared to the amount in the small volume of the nerve. In part, this reflects the fact that WGA adheres to muscle cell membranes [36] as well as being taken up by adsorptive endocytosis at nerve ter- mini. This also explains a depot effect...

  8. Coal Transportation Rate Sensitivity Analysis

    Reports and Publications (EIA)

    2005-01-01

    On December 21, 2004, the Surface Transportation Board (STB) requested that the Energy Information Administration (EIA) analyze the impact of changes in coal transportation rates on projected levels of electric power sector energy use and emissions. Specifically, the STB requested an analysis of changes in national and regional coal consumption and emissions resulting from adjustments in railroad transportation rates for Wyoming's Powder River Basin (PRB) coal using the National Energy Modeling System (NEMS). However, because NEMS operates at a relatively aggregate regional level and does not represent the costs of transporting coal over specific rail lines, this analysis reports on the impacts of interregional changes in transportation rates from those used in the Annual Energy Outlook 2005 (AEO2005) reference case.

  9. Energy Intensity Indicators: Transportation Energy Consumption

    Broader source: Energy.gov [DOE]

    This section contains an overview of the aggregate transportation sector, combining both passenger and freight segments of this sector. The specific energy intensity indicators for passenger and freight can be obtained from the links, passenger transportation, or freight transportation. For further detail within the transportation sector, download the appropriate Trend Data worksheet containing detailed data and graphics for specific transportation modes.

  10. Transportes em Revista.com Pas: Portugal

    E-Print Network [OSTI]

    Instituto de Sistemas e Robotica

    Transportes em Revista.com País: Portugal Period.: Diária Âmbito: Online Pag.: 1 de 2ID: 41904396 22-05-2012 Receba gr átis a Transportes Online | Assinar a Transportes em Revista | Fazer da TR a sua Transport Rodas de mudança Et si nos villes #12;Transportes em Revista.com País:

  11. February 2011 1906: Pure Food & Drugs Act regulated

    E-Print Network [OSTI]

    Arslan, Hüseyin

    February 2011 #12; 1906: Pure Food & Drugs Act ­ regulated adultered/misbranded food & drugs 1938: Food, Drugs, & Cosmetics Acts ­ required premarket review for safety 1962: FDCA Amendments ­ the birth for investigations of new drugs, including a requirement for informed consent #12; 21 CFR 312 Subpart A ­ general

  12. Uphill transport and the probabilistic transport model B. Ph. van Milligen

    E-Print Network [OSTI]

    van Milligen, Boudewijn

    Uphill transport and the probabilistic transport model B. Ph. van Milligen Asociacio´n EURATOM-CIEMAT

  13. Transport Survey 2008 (Staff and student)

    E-Print Network [OSTI]

    Burton, Geoffrey R.

    Transport Survey 2008 (Staff and student) April 2008 Ramon Arigoni Ortiz Wan-Jung Chou Department................................................................................................6 2. Transport use and travel behaviour......................................................................10 2.1. Modes of transport

  14. co2-transport | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Transport Cost Model FENETL CO2 Transport Cost Model About the model: This model was developed to estimate the cost of transporting a user-specified mass rate of CO2 by pipeline...

  15. Anomalous transport through porous and fractured media

    E-Print Network [OSTI]

    Kang, Peter Kyungchul

    2014-01-01

    Anomalous transport, understood as the nonlinear scaling with time of the mean square displacement of transported particles, is observed in many physical processes, including contaminant transport through porous and fractured ...

  16. Transportes em Revista.com Pas: Portugal

    E-Print Network [OSTI]

    Instituto de Sistemas e Robotica

    Transportes em Revista.com País: Portugal Period.: Diária Âmbito: Online Pag.: 1 de 2ID: 44168021 10-10-2012 Receba gr átis a Transportes Online | Assinar a Transportes em Revista | Fazer da TR a sua

  17. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance

    E-Print Network [OSTI]

    Clairambault, Jean

    period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

  18. Mar. Drugs 2015, 13, 3154-3181; doi:10.3390/md13053154 marine drugs

    E-Print Network [OSTI]

    Paré, Paul W.

    Mar. Drugs 2015, 13, 3154-3181; doi:10.3390/md13053154 marine drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs Review Molecular Architecture and Biomedical Leads of Terpenes from Red Sea Marine Invertebrates Mohamed Costantino Received: 9 April 2015 / Accepted: 7 May 2015 / Published: 20 May 2015 Abstract: Marine

  19. Mar. Drugs 2013, 11, 4370-4389; doi:10.3390/md11114370 marine drugs

    E-Print Network [OSTI]

    Eirin Lopez, Jose Maria

    Mar. Drugs 2013, 11, 4370-4389; doi:10.3390/md11114370 marine drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs Review Bivalve Omics: State of the Art and Potential Applications for the Biomonitoring of Harmful Marine of the marine ecosystem, constitute very valuable commercial resources in aquaculture, and have been widely used

  20. Transport Protocol Services (TAPS) Problem: more and more transport protocols available, with various features,

    E-Print Network [OSTI]

    Welzl, Michael

    Transport Protocol Services (TAPS) · Problem: more and more transport protocols that would not offer "TCP or UDP" but "transport services" ­ A transport system: transport-services@ifi.uio.no hXps://sympa.uio.no/ifi.uio.no/info/transport-services · Problem

  1. California’s Energy Future: Transportation Energy Use in California

    E-Print Network [OSTI]

    Yang, Christopher; Ogden, Joan M; Hwang, Roland; Sperling, Daniel

    2011-01-01

    truck activity in California. Transport Policy. Volume 16,in California Travel Demand Reductions Decreasing transportCalifornia, USA. Transportation Research, Part D: Transport

  2. Drug Free Workplace This notice is intended to meet the requirements of the Drug Free Workplace Act of 1988,

    E-Print Network [OSTI]

    Nicholson, Bruce J.

    Drug Free Workplace This notice is intended to meet the requirements of the Drug Free Workplace Act of 1988, United States Code Title 41, Chapter 81, and the Drug Free Schools and Communities Act Amendments revision date of September 1, 2016. Notice In accordance with the Drug Free Schools and Communities Act

  3. Predicting Drug-Target Interaction for New Drugs Using Enhanced Similarity Measures and Super-Target Clustering1

    E-Print Network [OSTI]

    Chin, Francis Y.L.

    Predicting Drug-Target Interaction for New Drugs Using Enhanced Similarity Measures and Super.hku.hk, FYLC: chin@cs.hku.hk * To whom correspondence should be addressed. Abstract--Predicting drug-target interaction using computa- tional approaches is an important step in drug discovery and repositioning

  4. Section 21: Drug Discovery/Delivery Pharmacokinetic Considerations of Local Drug Delivery to the Inner Ear by

    E-Print Network [OSTI]

    Salt, Alec N.

    1 Section 21: Drug Discovery/Delivery Pharmacokinetic Considerations of Local Drug Delivery.Plontke@uni-tuebingen.de Although there is increasing interest in the local delivery of drugs to the inner ear by applying them to the round window (RW) membrane, most drug application protocols have been empirically- based. As a result

  5. Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing

    E-Print Network [OSTI]

    Gates, Kent. S.

    CHEM 4170 Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing assignment, this is a literature research project. The data for your drug will be presented below. Do not choose a drug that has been discussed in detail in Silverman's Book or in class. You may

  6. Essays on Urban Transportation and Transportation Energy Policy

    E-Print Network [OSTI]

    Kim, Chun Kon

    2008-01-01

    E?ects of Transportation Energy policy on Tra?c Crashes .e?ciency standards. Energy Policy, 33(3), 407–419. Blincoe,what’s necessary? Energy Policy, 34(9), 971–974. Bose, R.

  7. Environment-Assisted Quantum Transport

    E-Print Network [OSTI]

    Patrick Rebentrost; Masoud Mohseni; Ivan Kassal; Seth Lloyd; Alán Aspuru-Guzik

    2009-02-10

    Transport phenomena at the nanoscale are of interest due to the presence of both quantum and classical behavior. In this work, we demonstrate that quantum transport efficiency can be enhanced by a dynamical interplay of the system Hamiltonian with pure dephasing induced by a fluctuating environment. This is in contrast to fully coherent hopping that leads to localization in disordered systems, and to highly incoherent transfer that is eventually suppressed by the quantum Zeno effect. We study these phenomena in the Fenna-Matthews-Olson protein complex as a prototype for larger photosynthetic energy transfer systems. We also show that disordered binary tree structures exhibit enhanced transport in the presence of dephasing.

  8. Momentum Transport in Granular Flows

    E-Print Network [OSTI]

    Gregg Lois; Anael Lemaitre; Jean M. Carlson

    2006-02-10

    We investigate the error induced by only considering binary collisions in the momentum transport of hard-sphere granular materials, as is done in kinetic theories. In this process, we first present a general microscopic derivation of the momentum transport equation and compare it to the kinetic theory derivation, which relies on the binary collision assumption. These two derivations yield different microscopic expressions for the stress tensor, which we compare using simulations. This provides a quantitative bound on the regime where binary collisions dominate momentum transport and reveals that most realistic granular flows occur in the region of phase space where the binary collision assumption does not apply.

  9. Quantum transport through aromatic molecules

    SciTech Connect (OSTI)

    Ojeda, J. H.; Rey-González, R. R.; Laroze, D.

    2013-12-07

    In this paper, we study the electronic transport properties through aromatic molecules connected to two semi-infinite leads. The molecules are in different geometrical configurations including arrays. Using a nearest neighbor tight-binding approach, the transport properties are analyzed into a Green's function technique within a real-space renormalization scheme. We calculate the transmission probability and the Current-Voltage characteristics as a function of a molecule-leads coupling parameter. Our results show different transport regimes for these systems, exhibiting metal-semiconductor-insulator transitions and the possibility to employ them in molecular devices.

  10. Turbulence Induced Transport in Tokamaks

    SciTech Connect (OSTI)

    Caldas, I. L.; Marcus, F. A.; Heller, M. V. A. P.; Guimaraes-Filho, Z. O. [Instituto de Fisica, Universidade de Sao Paulo, Caixa Postal 66318, 05315-970, Sao Paulo, SP (Brazil); Batista, A. M. [Departamento de Matematica e Estatistica, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR (Brazil); Viana, R. L.; Lopes, S. R. [Departamento de Fisica, Universidade Federal do Parana, 81531-990, Curitiba, PR (Brazil); Morrison, P. J.; Horton, W. [Department of Physics, University of Texas at Austin, Austin, Texas, 78712 (United States); Institute for Fusion Studies, The University of Texas at Austin, Austin, Texas, 78712 (United States)

    2006-12-04

    This report is concerned with plasma edge turbulence and its relation to anomalous particle transport in tokamaks. First, experimental evidence of turbulence driven particle transport and measurements of the gradients of the equilibrium profiles in the Brazilian tokamaks TBR and TCABR are presented. Next, diffusion in a two drift-wave system is discussed. In this nonintegrable system, particle transport is associated with the onset of chaotic orbits. Finally, numerical evidence suggesting that a nonlinear three-mode interaction could contribute to the intermittent plasma fluctuations observed in tokamaks is presented.

  11. UFD Storage and Transportation - Transportation Working Group Report

    SciTech Connect (OSTI)

    Maheras, Steven J.; Ross, Steven B.

    2011-08-01

    The Used Fuel Disposition (UFD) Transportation Task commenced in October 2010. As its first task, Pacific Northwest National Laboratory (PNNL) compiled a list of structures, systems, and components (SSCs) of transportation systems and their possible degradation mechanisms during extended storage. The list of SSCs and the associated degradation mechanisms [known as features, events, and processes (FEPs)] were based on the list of used nuclear fuel (UNF) storage system SSCs and degradation mechanisms developed by the UFD Storage Task (Hanson et al. 2011). Other sources of information surveyed to develop the list of SSCs and their degradation mechanisms included references such as Evaluation of the Technical Basis for Extended Dry Storage and Transportation of Used Nuclear Fuel (NWTRB 2010), Transportation, Aging and Disposal Canister System Performance Specification, Revision 1 (OCRWM 2008), Data Needs for Long-Term Storage of LWR Fuel (EPRI 1998), Technical Bases for Extended Dry Storage of Spent Nuclear Fuel (EPRI 2002), Used Fuel and High-Level Radioactive Waste Extended Storage Collaboration Program (EPRI 2010a), Industry Spent Fuel Storage Handbook (EPRI 2010b), and Transportation of Commercial Spent Nuclear Fuel, Issues Resolution (EPRI 2010c). SSCs include items such as the fuel, cladding, fuel baskets, neutron poisons, metal canisters, etc. Potential degradation mechanisms (FEPs) included mechanical, thermal, radiation and chemical stressors, such as fuel fragmentation, embrittlement of cladding by hydrogen, oxidation of cladding, metal fatigue, corrosion, etc. These degradation mechanisms are discussed in Section 2 of this report. The degradation mechanisms have been evaluated to determine if they would be influenced by extended storage or high burnup, the need for additional data, and their importance to transportation. These categories were used to identify the most significant transportation degradation mechanisms. As expected, for the most part, the transportation importance was mirrored by the importance assigned by the UFD Storage Task. A few of the more significant differences are described in Section 3 of this report

  12. Texarkana Urban Transportation Study 2035 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Texarkana Metropolitan Planning Organization

    2009-10-01

    And Local Resource Agencies 1-7 Inclusion of Indian Tribes in the Transportation Process 1-8 2 SOCIO-ECONOMIC DATA 5 ROADS & BRIDGES Population Data 2-1 Road Performance 5-1 Housing Data 2... to increased motor fuels taxes or alternative revenue sources 4. Decaying infrastructure 5. Increasing demand for new infrastructure and access to alternative modes Starting with the Intermodal Surface Transportation Act of 1991 (ISTEA), the regulatory...

  13. Transportation Issues and Resolutions Compilation of Laboratory...

    Office of Environmental Management (EM)

    of cladding (embrittled, high burnup cladding, loads applied to cladding during transport), criticality analyses of failed UNF within transport packages, moderator exclusion...

  14. Anomalous energy transport across topological insulator superconductor...

    Office of Scientific and Technical Information (OSTI)

    Anomalous energy transport across topological insulator superconductor junctions Citation Details In-Document Search Title: Anomalous energy transport across topological insulator...

  15. Coal Gasification and Transportation Fuels Magazine

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Coal Gasification and Transportation Fuels Magazine Current Edition: Coal Gasification and Transportation Fuels Quarterly News, Vol.1, Issue 4 (July 2015) Archived Editions: Coal...

  16. Nearly 200 Attend National Transportation Stakeholders Forum...

    Office of Environmental Management (EM)

    national transportation coordination. BUFFALO, N.Y. - In his keynote address at the fourth-annual DOE National Transportation Stakeholders Forum (NTSF) meeting, EM Senior...

  17. Spring 2015 National Transportation Stakeholders Forum Meeting...

    Broader source: Energy.gov (indexed) [DOE]

    Spring 2015 National Transportation Stakeholders Forum Meeting, New Mexico The Spring 2015 meeting of the National Transportation Stakeholders Forum will be held on May 12-14, 2015...

  18. Transportation Equipment (2010 MECS) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Equipment (2010 MECS) Transportation Equipment (2010 MECS) Manufacturing Energy and Carbon Footprint for Transportation Equipment Sector (NAICS 336) Energy use data source:...

  19. Transportation Safeguards & Security Test Bed (TSSTB) | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Transportation Safeguards and Security Test Bed May 30, 2013 The Transportation Safeguards and Security Test Bed consists of a test-bed vehicle and a monitoringlaboratorytraining...

  20. Standardization of Transport Properties Measurements: Internal...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Standardization of Transport Properties Measurements: Internal Energy Agency (IEA-AMT) Annex on Thermoelectric Standardization of Transport Properties Measurements: Internal Energy...

  1. We're All Transportation Planners

    E-Print Network [OSTI]

    Curry, Melanie

    2006-01-01

    transportation ment, has had some success in London’sLondon, offering our individual contribution to them. obser vations on current transportation

  2. Vehicle Technologies Office Merit Review 2015: Transportation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Transportation Energy Data Book, Vehicle Technologies Market Report, and VT Fact of the Week Vehicle Technologies Office Merit Review 2015: Transportation Energy Data Book, Vehicle...

  3. Vehicle Technologies Office Merit Review 2014: Transportation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Transportation Energy Data Book, Vehicle Technologies Market Report, and VT Fact of the Week Vehicle Technologies Office Merit Review 2014: Transportation Energy Data Book, Vehicle...

  4. Department of Transportation Pipeline and Hazardous Materials...

    Office of Environmental Management (EM)

    Conroy U S Department of Transportation - 1 - U.S. Department of Transportation Pipeline and Hazardous Materials Safety Administration Office of Hazardous Materials Safety...

  5. QER - Comment of Electric Drive Transportation Association |...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Drive Transportation Association QER - Comment of Electric Drive Transportation Association From: Genevieve Cullen gcullen@electricdrive.org Sent: Friday, October 10, 2014 11:58...

  6. EM Waste and Materials Disposition & Transportation

    Office of Environmental Management (EM)

    On Closure Success 1 EM Waste and Materials Disposition & Transportation National Transportation Stakeholders Forum Chicago, Illinois May 26, 2010 Frank Marcinowski Acting Chief...

  7. Assembly and electrical transport characterization of nanostructures...

    Office of Scientific and Technical Information (OSTI)

    Conference: Assembly and electrical transport characterization of nanostructures. Citation Details In-Document Search Title: Assembly and electrical transport characterization of...

  8. EM Waste and Materials Disposition & Transportation | Department...

    Office of Environmental Management (EM)

    & Transportation EM Waste and Materials Disposition & Transportation DOE's Radioactive Waste Management Priorities: Continue to manage waste inventories in a safe and compliant...

  9. Seamless Transport Policy: Institutional and Regulatory Aspects...

    Open Energy Info (EERE)

    Seamless Transport Policy: Institutional and Regulatory Aspects of Inter-Modal Coordination Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Seamless Transport Policy:...

  10. Spring 2013 National Transportation Stakeholders Forum Meeting...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Stakeholders Forum Spring 2013 National Transportation Stakeholders Forum Meeting, New York Spring 2013 National Transportation Stakeholders Forum Meeting, New York Spring...

  11. Mitochondrial Transport and Function in Axon Degeneration

    E-Print Network [OSTI]

    O'Donnell, Kelley

    2013-01-01

    OF CALIFORNIA Los Angeles Mitochondrial Transport andTransport and Function in Axon Degeneration by Kelley O’Donnell Doctor of Philosophy in Neuroscience University of California,

  12. Transportation and Stationary Power Integration Workshop Agenda...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Agenda, October 27, 2008, Phoenix, Arizonia Transportation and Stationary Power Integration Workshop Agenda, October 27, 2008, Phoenix, Arizonia Agenda for the Transportation and...

  13. Transportation, Aging and Disposal Canister System Performance...

    Broader source: Energy.gov (indexed) [DOE]

    document provides specifications for selected system components of the Transportation, Aging and Disposal (TAD) canister-based system. Transportation, Aging and Disposal Canister...

  14. Macrobiotic Vertical Transport of Litter Derived Carbon

    E-Print Network [OSTI]

    Post, Wilfred M.

    Macrobiotic Vertical Transport of Litter Derived Carbon (Earthworm Phase) Mac Callaham Corey Babb in each treatment Sampling #12;Macrobiotic Vertical Transport of Litter Derived Carbon (millipede phase

  15. Oxygen Transport Ceramic Membranes

    SciTech Connect (OSTI)

    S. Bandopadhyay; N. Nagabhushana

    2003-08-07

    In the present quarter, experiments are presented on ceramic/metal interactions of Zirconia/ Ni-B-Si system and with a thin Ti coating deposited on zirconia surface. Existing facilities were modified for evaluation of environmental assisted slow crack growth and creep in flexural mode. Processing of perovskites of LSC, LSF and LSCF composition were continued for evaluation of mechanical properties as a function of environment. These studies in parallel to those on the LSFCO composition is expect to yield important information on questions such as the role of cation segregation and the stability of the perovskite structure on crack initiation vs. crack growth. Studies have been continued on the La{sub 1-x}Sr{sub x}FeO{sub 3-d} composition using neutron diffraction and TGA studies. A transition from p-type to n-type of conductor was observed at relative low pO{sub 2}, at which the majority carriers changed from the holes to electrons because of the valence state decreases in Fe due to the further loss of oxygen. Investigation on the thermodynamic properties of the membrane materials are continued to develop a complete model for the membrane transport. Data obtained at 850 C show that the stoichiometry in La{sub 0.2}Sr{sub 0.8}Fe{sub 0.8}Cr{sub 0.2}O{sub 3-x} vary from {approx}2.85 to 2.6 over the pressure range studied. From the stoichiometry a lower limit of 2.6 corresponding to the reduction of all Fe{sup 4+} to Fe{sup 3+} and no reduction of Cr{sup 3+} is expected.

  16. Seasonality in air transportation demand

    E-Print Network [OSTI]

    Reichard Megwinoff, H?tor Nicolas

    1988-01-01

    This thesis investigates the seasonality of demand in air transportation. It presents three methods for computing seasonal indices. One of these methods, the Periodic Average Method, is selected as the most appropriate for ...

  17. Washington: Integrated Transportation Programs & Coordinated...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    trip planner site that pulls together all regional transportation options into one portal. The project has already resulted in a reduction of 5.9 million vehicle miles traveled...

  18. Aerosol penetration through transport lines 

    E-Print Network [OSTI]

    Dileep, V.R.

    1996-01-01

    It is very important to minimize the losses in aerosol transport systems for the Continuous Air Monitors (CAM) to have a prompt and a meaningful alarm and the U.S. Environmental Protection Agency (EPA) also Currently mandates continuous emissions...

  19. Transportation scenarios for risk analysis.

    SciTech Connect (OSTI)

    Weiner, Ruth F.

    2010-09-01

    Transportation risk, like any risk, is defined by the risk triplet: what can happen (the scenario), how likely it is (the probability), and the resulting consequences. This paper evaluates the development of transportation scenarios, the associated probabilities, and the consequences. The most likely radioactive materials transportation scenario is routine, incident-free transportation, which has a probability indistinguishable from unity. Accident scenarios in radioactive materials transportation are of three different types: accidents in which there is no impact on the radioactive cargo, accidents in which some gamma shielding may be lost but there is no release of radioactive material, and accident in which radioactive material may potentially be released. Accident frequencies, obtainable from recorded data validated by the U.S. Department of Transportation, are considered equivalent to accident probabilities in this study. Probabilities of different types of accidents are conditional probabilities, conditional on an accident occurring, and are developed from event trees. Development of all of these probabilities and the associated highway and rail accident event trees are discussed in this paper.

  20. Apparatus for transporting hazardous materials

    DOE Patents [OSTI]

    Osterman, Robert A. (Canonsburg, PA); Cox, Robert (West Mifflin, PA)

    1992-01-01

    An apparatus and method are provided for selectively receiving, transporting, and releasing one or more radioactive or other hazardous samples for analysis on a differential thermal analysis (DTA) apparatus. The apparatus includes a portable sample transporting apparatus for storing and transporting the samples and includes a support assembly for supporting the transporting apparatus when a sample is transferred to the DTA apparatus. The transporting apparatus includes a storage member which includes a plurality of storage chambers arrayed circumferentially with respect to a central axis. An adjustable top door is located on the top side of the storage member, and the top door includes a channel capable of being selectively placed in registration with the respective storage chambers thereby permitting the samples to selectively enter the respective storage chambers. The top door, when closed, isolates the respective samples within the storage chambers. A plurality of spring-biased bottom doors are located on the bottom sides of the respective storage chambers. The bottom doors isolate the samples in the respective storage chambers when the bottom doors are in the closed position. The bottom doors permit the samples to leave the respective storage chambers from the bottom side when the respective bottom doors are in respective open positions. The bottom doors permit the samples to be loaded into the respective storage chambers after the analysis for storage and transport to a permanent storage location.

  1. Alcohol Transportation Fuels Demonstration Program

    SciTech Connect (OSTI)

    Kinoshita, C.M. (ed.)

    1990-01-01

    Hawaii has abundant natural energy resources, especially biomass, that could be used to produce alternative fuels for ground transportation and electricity. This report summarizes activities performed during 1988 to June 1991 in the first phase of the Alcohol Transportation Fuels Demonstration Program. The Alcohol Transportation Fuels Demonstration Program was funded initially by the Energy Division of the State of Hawaii's Department of Business, Economic Development and Tourism, and then by the US Department of Energy. This program was intended to support the transition to an altemative transportation fuel, methanol, by demonstrating the use of methanol fuel and methanol-fueled vehicles, and solving the problems associated with that fuel. Specific objectives include surveying renewable energy resources and ground transportation in Hawaii; installing a model methanol fueling station; demonstrating a methanol-fueled fleet of (spark-ignition engine) vehicles; evaluating modification strategies for methanol-fueled diesel engines and fuel additives; and investigating the transition to methanol fueling. All major objectives of Phase I were met (survey of local renewable resources and ground transportation, installation of methanol refueling station, fleet demonstration, diesel engine modification and additive evaluation, and dissemination of information on alternative fueling), and some specific problems (e.g., relating to methanol fuel contamination during handling and refueling) were identified and solved. Several key issues emerging from Phase I (e.g., methanol corrosion, flame luminosity, and methanol-transition technoeconomics) were recommended as topics for follow-on research in subsequent phases of this program.

  2. Uranium Transport Modeling

    SciTech Connect (OSTI)

    Bostick, William D.

    2008-01-15

    Uranium contamination is prevalent at many of the U.S. DOE facilities and at several civilian sites that have supported the nuclear fuel cycle. The potential off-site mobility of uranium depends on the partitioning of uranium between aqueous and solid (soil and sediment) phases. Hexavalent U (as uranyl, UO{sub 2}{sup 2+}) is relatively mobile, forming strong complexes with ubiquitous carbonate ion which renders it appreciably soluble even under mild reducing conditions. In the presence of carbonate, partition of uranyl to ferri-hydrate and select other mineral phases is usually maximum in the near-neutral pH range {approx} 5-8. The surface complexation reaction of uranyl with iron-containing minerals has been used as one means to model subsurface migration, used in conjunction with information on the site water chemistry and hydrology. Partitioning of uranium is often studied by short-term batch 'equilibrium' or long-term soil column testing ; MCLinc has performed both of these methodologies, with selection of method depending upon the requirements of the client or regulatory authority. Speciation of uranium in soil may be determined directly by instrumental techniques (e.g., x-ray photoelectron spectroscopy, XPS; x-ray diffraction, XRD; etc.) or by inference drawn from operational estimates. Often, the technique of choice for evaluating low-level radionuclide partitioning in soils and sediments is the sequential extraction approach. This methodology applies operationally-defined chemical treatments to selectively dissolve specific classes of macro-scale soil or sediment components. These methods recognize that total soil metal inventory is of limited use in understanding bioavailability or metal mobility, and that it is useful to estimate the amount of metal present in different solid-phase forms. Despite some drawbacks, the sequential extraction method can provide a valuable tool to distinguish among trace element fractions of different solubility related to mineral phases. Four case studies are presented: Water and Soil Characterization, Subsurface Stabilization of Uranium and other Toxic Metals, Reductive Precipitation (in situ bioremediation) of Uranium, and Physical Transport of Particle-bound Uranium by Erosion.

  3. Alcohol and Other Drugs Education and Prevention

    E-Print Network [OSTI]

    . · The School's commitment to conducting a biennial review of its program. Employees, like students, are coveredAlcohol and Other Drugs Education and Prevention Policy Responsible Administrative Unit: Student.0 BACKGROUND AND PURPOSE The Colorado School of Mines is committed to: · Providing students educational

  4. RELATED ARTICLES Pricey Hepatitis C Drug Draws

    E-Print Network [OSTI]

    Kay, Mark A.

    Listen Tweet 28 RELATED ARTICLES Pricey Hepatitis C Drug Draws Criticism World Hepatitis Day Highlights Global Scourge, Hopes for Treatment News / Health Elimination of Chronic Hepatitis Feasible FILE A nurse vaccinates a child against hepatitis to prevent disease in Constitucion, Chile. Lisa Schlein July

  5. Poly(ethylene glycol)-conjugated multi-walled carbon nanotubes as an efficient drug carrier for overcoming multidrug resistance

    SciTech Connect (OSTI)

    Cheng Jinping [Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon (Hong Kong); Meziani, Mohammed J.; Sun Yaping [Department of Chemistry and Laboratory for Emerging Materials and Technology, Clemson University, Clemson, SC 29634-0973 (United States); Cheng, Shuk Han, E-mail: bhcheng@cityu.edu.hk [Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon (Hong Kong)

    2011-01-15

    The acquisition of multidrug resistance poses a serious problem in chemotherapy, and new types of transporters have been actively sought to overcome it. In the present study, poly(ethylene glycol)-conjugated (PEGylated) multi-walled carbon nanotubes (MWCNTs) were prepared and explored as drug carrier to overcome multidrug resistance. The prepared PEGylated MWCNTs penetrated into mammalian cells without damage plasma membrane, and its accumulation did not affect cell proliferation and cell cycle distribution. More importantly, PEGylated MWCNTs accumulated in the multidrug-resistant cancer cells as efficient as in the sensitive cancer cells. Intracellular translocation of PEGylated MWCNTs was visualized in both multidrug-resistant HepG2-DR cells and sensitive HepG2 cells, as judged by both fluorescent and transmission electron microscopy. PEGylated MWCNTs targeted cancer cells efficiently and multidrug-resistant cells failed to remove the intracellular MWCNTs. However, if used in combination with drugs without conjugation, PEGylated MWCNTs prompted drug efflux in MDR cells by stimulating the ATPase activity of P-glycoprotein. This study suggests that PEGylated MWCNTs can be developed as an efficient drug carrier to conjugate drugs for overcoming multidrug resistance in cancer chemotherapy.

  6. ENERGY TRANSPORT IN SEMICONDUCTOR DEVICES ANSGAR JUNGEL

    E-Print Network [OSTI]

    Jüngel, Ansgar

    ENERGY TRANSPORT IN SEMICONDUCTOR DEVICES ANSGAR J¨UNGEL Abstract. The modeling, analysis, and numerical approximation of energy-transport models for semiconductor devices is reviewed. The derivation-dependent energy-transport equations with physical transport coefficients. The discretization of the stationary

  7. Anomalous radial transport in tokamak edge plasma

    E-Print Network [OSTI]

    Bodi, Vasudeva Raghavendra Kowsik

    2010-01-01

    Transport in tokamak plasma . . . . . . . . . . . . . . .Numerical simulations of tokamak plasma . . . . . . . . .of blobs in tokamak edge plasmas . . . . . . . . . . . . . .

  8. Biofuel Feedstock Inter-Island Transportation

    E-Print Network [OSTI]

    of Honolulu Advertiser ISO Tank Container, courtesy of Hawaii Intermodal Tank Transport Petroleum products

  9. Public Transport and Sustainable Urbanism: Global Lesson

    E-Print Network [OSTI]

    Cervero, Robert

    2006-01-01

    Public Transport and Sustainable Urbanism: Global Lessonsviable and sustainable form of urbanism. Notes J. Kenworthy

  10. Pion capture and transport system for PRISM

    E-Print Network [OSTI]

    McDonald, Kirk

    solenoid cold mass Transport pions+muons in long 2T solenoid channelPion capture and transport system for PRISM M. Yoshida Osaka Univ. 2005/8/28 NuFACT06 at UCI #12 and transport system proton beam Phase rotator PRIME detector #12;Concepts of pion capture/transport system

  11. Enhancing Resource Sustainability by Transforming Urban and Suburban Transportation

    E-Print Network [OSTI]

    Delucchi, Mark

    2009-01-01

    Sustainable Transportation, Smart Growth, and New Urbanismsustainable transportation,” “smart growth,” and “new urbanism”

  12. Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bolla, Jani Reddy; Su, Chih-Chia; Delmar, Jared A.; Radhakrishnan, Abhijith; Kumar, Nitin; Chou, Tsung-Han; Long, Feng; Rajashankar, Kanagalaghatta R.; Yu, Edward W.

    2015-04-20

    The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been clinically validated. However, many pathogens have developed resistance to these antibiotics, prompting a re-evaluation of potential drug targets within the pathway. The ydaH gene of Alcanivorax borkumensis encodes an integral membrane protein of the AbgT family of transporters for which no structural information was available. Here we report the crystal structure of A. borkumensis YdaH, revealing a dimeric molecule with an architecture distinct from other families of transporters. YdaH is a bowl-shaped dimer with a solvent-filled basin extending from the cytoplasm tomore »halfway across the membrane bilayer. Each subunit of the transporter contains nine transmembrane helices and two hairpins that suggest a plausible pathway for substrate transport. Further analyses also suggest that YdaH could act as an antibiotic efflux pump and mediate bacterial resistance to sulfonamide antimetabolite drugs.« less

  13. Toledo Regional Economic PlanToledo Regional Economic Plan Transportation and LogisticsTransportation and Logistics

    E-Print Network [OSTI]

    Azad, Abdul-Majeed

    Toledo Regional Economic PlanToledo Regional Economic Plan Transportation and LogisticsTransportation and Logistics Industry SectorIndustry Sector Submitted by:Submitted by: Transportation and Logistics Working GroupTransportation and Logistics Working Group September 2009September 2009 #12;22 Transportation

  14. Luminal flow amplifies stent-based drug deposition in arterial

    E-Print Network [OSTI]

    Levine, Evan G.

    Background: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely ...

  15. Regression analysis of oncology drug licensing deal values

    E-Print Network [OSTI]

    Hawkins, Paul Allen

    2006-01-01

    This work is an attempt to explain wide variations in drug licensing deal value by using regression modeling to describe and predict the relationship between oncology drug deal characteristics and their licensing deal ...

  16. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Takeda Advances Diabetes Drug Development at the ALS Print Tuesday, 19 May 2015 12:25 Type 2 diabetes mellitus (T2DM),...

  17. Optimization of preclinical profiling operations in drug discovery

    E-Print Network [OSTI]

    Heiney, John P. (John Patrick)

    2007-01-01

    In early-stage drug discovery, thousands of compounds must be tested using in vitro assays to determine their exposure and safety characteristics. This data is used to guide the selection of potential drug candidates and ...

  18. Measuring the effects of drugs on single cancer cell growth

    E-Print Network [OSTI]

    Weng, Yaochung

    2012-01-01

    Understanding the effectiveness of a drug therapy on halting disease progression is an essential aspect of cancer biology. Conventional assays that study cell behavior after a drug intervention report the average response ...

  19. Specific and general binding in arterial drug delivery

    E-Print Network [OSTI]

    Levin, Andrew D. (Andrew David), 1976-

    2005-01-01

    Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

  20. Amphiphilic linear-dendritic block copolymers for drug delivery

    E-Print Network [OSTI]

    Nguyen, Phuong, Ph. D. Massachusetts Institute of Technology

    2007-01-01

    Polymeric drug delivery systems have been widely used in the pharmaceutical industry. Such systems can solubilize and sequester hydrophobic drugs from degradation, thereby increasing circulation half-life and efficacy. ...

  1. Alignment strategies for drug product process development and manufacturing

    E-Print Network [OSTI]

    Garvin, Christopher John

    2012-01-01

    The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the product-process interaction ...

  2. Overcoming Drug Resistance by Co-Targeting Marzieh Ayati1

    E-Print Network [OSTI]

    Wong, Limsoon

    , Statistics and Computer Science, University of Tehran, Tehran, Iran Abstract Removal or suppression of key to the drug. Communica- tion to the resistance machinery---e.g., efflux pumps and drug-modifying enzymes

  3. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  4. Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs

    E-Print Network [OSTI]

    Stauber, Zachary Jason

    2012-01-01

    Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

  5. Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System 

    E-Print Network [OSTI]

    Yu, Xiao

    2012-07-16

    Hydrophobic drug paclitaxel nanoparticles (PAX NPs) and pH sensitive hydrogels were prepared in this study to build a colon targeting nanoparticle based drug delivery system for oral administration. Negative charged PAX NPs at the size of 110...

  6. Research Articles Combining Drug and Gene Similarity Measures

    E-Print Network [OSTI]

    Sharan, Roded

    of drug-drug and gene-gene similarity measures, combined with a logistic regression component to detection problems due to multiple gene and compound names. Additional attempts were based on reverse

  7. Methods of producing transportation fuel

    DOE Patents [OSTI]

    Nair, Vijay (Katy, TX); Roes, Augustinus Wilhelmus Maria (Houston, TX); Cherrillo, Ralph Anthony (Houston, TX); Bauldreay, Joanna M. (Chester, GB)

    2011-12-27

    Systems, methods, and heaters for treating a subsurface formation are described herein. At least one method for producing transportation fuel is described herein. The method for producing transportation fuel may include providing formation fluid having a boiling range distribution between -5.degree. C. and 350.degree. C. from a subsurface in situ heat treatment process to a subsurface treatment facility. A liquid stream may be separated from the formation fluid. The separated liquid stream may be hydrotreated and then distilled to produce a distilled stream having a boiling range distribution between 150.degree. C. and 350.degree. C. The distilled liquid stream may be combined with one or more additives to produce transportation fuel.

  8. No energy transport without discord

    E-Print Network [OSTI]

    Seth Lloyd; Vazrik Chiloyan; Yongjie Hu; Samuel Huberman; Zi-Wen Liu; Gang Chen

    2015-10-16

    Quantum systems can be correlated in ways that classical systems can not. A wide variety of non-classical forms of correlation exist: amongst the best known are entanglement and discord. Quantum correlations can be used to enhance measurement accuracy and energy transport. This paper shows that quantum correlations -- in the form of discord -- are mandatory for any energy transport. Without discord, energy transport cannot occur. Moreover, we show that the initial rate of heat transfer between two systems prepared at different temperatures is directly proportional to the rate of increase in diagonal/energetic discord between the systems. We measured the increase of energetic discord induced by nanoscale heat flow across an aluminum-sapphire interface. The rate of increase of discord is measured to be 4.28*10^24 bits m^{-2} K^{-1} s^{-1}.

  9. Cavity enhanced transport of excitons

    E-Print Network [OSTI]

    Johannes Schachenmayer; Claudiu Genes; Edoardo Tignone; Guido Pupillo

    2015-05-20

    We show that exciton-type transport in certain materials can be dramatically modified by their inclusion in an optical cavity: the modification of the electromagnetic vacuum mode structure introduced by the cavity leads to transport via delocalized polariton modes rather than through tunneling processes in the material itself. This can help overcome exponential suppression of transmission properties as a function of the system size in the case of disorder and other imperfections. We exemplify massive improvement of transmission for excitonic wave-packets through a cavity, as well as enhancement of steady-state exciton currents under incoherent pumping. These results may have implications for experiments of exciton transport in disordered organic materials. We propose that the basic phenomena can be observed in quantum simulators made of Rydberg atoms, cold molecules in optical lattices, as well as in experiments with trapped ions.

  10. Quantum transport in ultracold atoms

    E-Print Network [OSTI]

    Chih-Chun Chien; Sebastiano Peotta; Massimiliano Di Ventra

    2015-04-11

    Ultracold atoms confined by engineered magnetic or optical potentials are ideal systems for studying phenomena otherwise difficult to realize or probe in the solid state because their atomic interaction strength, number of species, density, and geometry can be independently controlled. This review focuses on quantum transport phenomena in atomic gases that mirror and oftentimes either better elucidate or show fundamental differences with those observed in mesoscopic and nanoscopic systems. We discuss significant progress in performing transport experiments in atomic gases, contrast similarities and differences between transport in cold atoms and in condensed matter systems, and survey inspiring theoretical predictions that are difficult to verify in conventional setups. These results further demonstrate the versatility offered by atomic systems in the study of nonequilibrium phenomena and their promise for novel applications.

  11. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement.

    E-Print Network [OSTI]

    2009-01-01

    nonsteroidal anti-in? ammatory drugs and risk of colorectalof nonsteroidal antiin? ammatory drugs: a pooled analysis ofsteroidal anti-in? ammatory drugs on colorectal adenomas:

  12. Anti-cancer drugs elicit re-expression of UDP-glucuronosyltransferases in melanoma cells.

    E-Print Network [OSTI]

    Dellinger, Ryan W; Matundan, Harry H; Ahmed, Amelia S; Duong, Priscilla H; Meyskens, Frank L Jr

    2012-01-01

    effect of valproic acid on drug and steroid glucuronidationglucuronosyltrans- ferases. Curr Drug Metab 1: 143–161. 10.aerodigestive tract tissues. Drug Metab Dispos 30: 397–403.

  13. Vapor Transport in Dry Soils

    SciTech Connect (OSTI)

    Gee, Glendon W.; Ward, Anderson L.

    2001-11-16

    Water-vapor movement in soils is a complex process, controlled by both diffusion and advection and influenced by pressure and thermal gradients acting across tortuous flow paths. Wide-ranging interest in water-vapor transport includes both theoretical and practical aspects. Just how pressure and thermal gradients enhance water-vapor flow is still not completely understood and subject to ongoing research. Practical aspects include dryland farming (surface mulching), water harvesting (aerial wells), fertilizer placement, and migration of contaminants at waste-sites. The following article describes the processes and practical applications of water-vapor transport, with emphasis on unsaturated (dry) soil systems.

  14. San Augustine School Transportation Building 

    E-Print Network [OSTI]

    Raiford Stripling Associates, Inc.; Stripling, Raiford L.

    2011-08-29

    ON FLUCTUATIONS IN TEE GEOSTROPHIC VOLUKE TRANSPORT OF TEE LAEBADOR CURBZlT A Thesis RIC&MB FOSTER EOHNSON Suhmitted to the Graduate College of Texas AA":i University in partial fulf~meni of ths rec;uirement for the degree of NA, '3TER... OF SCIENCE August 19'Pg H" Jor Sub?'ect: Hctsci clogy' ON FLUCTUAT10NS IN THE GEOSTROPHIC VOLUME TRANSPORT OF THE LAHRADOR CURRENT A Thesis RICHARD FOSTER JOHNSON Approved as to style and oontent by: onairman of Committee Member Head of Department...

  15. Transportation Resources | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.WeekProducts >Transportation currentlyTransportation

  16. Influence of Transport Variables on Isospin Transport Ratios

    E-Print Network [OSTI]

    D. D. S. Coupland; W. G. Lynch; M. B. Tsang; P. Danielewicz; Yingxun Zhang

    2011-07-19

    The symmetry energy in the nuclear equation of state affects many aspects of nuclear astrophysics, nuclear structure, and nuclear reactions. Recent constraints from heavy ion collisions, including isospin diffusion observables, have started to put constraints on the symmetry energy below nuclear saturation density, but these constraints depend on the employed transport model and input physics other than the symmetry energy. To understand these dependencies, we study the influence of the symmetry energy, isoscaler mean field compressibility and momentum dependence, in-medium nucleon-nucleon cross sections, and light cluster production on isospin diffusion within the pBUU transport code. In addition to the symmetry energy, several uncertain issues strongly affect isospin diffusion, most notably the cross sections and cluster production. In addition, there is a difference in the calculated isospin transport ratios, depending upon whether they are computed using the isospin asymmetry of either the residue or of all forward moving fragments. Measurements that compare the isospin transport ratios of these two quantities would help place constraints on the input physics, such as the density dependence of the symmetry energy.

  17. WVU Transportation Services http://transportation.wvu.edu/

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    Route Options Greyhound · Daily Bus Service to Pittsburgh, PA, Washington, D.C., Clarksburg to Pittsburgh, PA and Washington, D.C. With Routes Through Canada Alternative Transportation Services http on the front of your permit. · Any permit area after 5:00 pm that is not 24 hour restricted Monday thru Friday

  18. Drug-Free Federal Workplace Testing Implementation Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1988-07-29

    The order provides guidance and policy for the administration, application and implementation of the DOE Drug-free Federal Workplace Plan and other regulations that facilitate the maintenance of a drug-free Federal workplace through the establishment of programs to test for the use of illegal drugs. Chg 1, dated 8-21-92

  19. Model-Based Dependability Analysis of Programmable Drug Infusion Pumps

    E-Print Network [OSTI]

    Sankaranarayanan, Sriram

    Model-Based Dependability Analysis of Programmable Drug Infusion Pumps Sriram Sankaranarayanan.lastname@colorado.edu Abstract. Infusion pumps are commonly used in home/hospital care to inject drugs into a patient a case-study involving an infusion pump used to manage pain through the infusion of analgesic drugs

  20. UNIVERSITY OF ABERDEEN POLICY ON DRUGS AND ALCOHOL

    E-Print Network [OSTI]

    Neri, Peter

    UNIVERSITY OF ABERDEEN POLICY ON DRUGS AND ALCOHOL 1 INTRODUCTION 1.1 The University of Aberdeen, and the introduction of a drugs and alcohol policy is intended to form an integral part of that approach. 1 and consistently. The University recognises that alcohol/drug dependency is an illness and will be treated

  1. An Algorithmic Framework for Predicting Side-Effects of Drugs

    E-Print Network [OSTI]

    Sharan, Roded

    An Algorithmic Framework for Predicting Side-Effects of Drugs Nir Atias and Roded Sharan Blavatnik,roded}@post.tau.ac.il Abstract. One of the critical stages in drug development is the iden- tification of potential side effects for promising drug leads. Large scale clinical experiments aimed at discovering such side effects are very

  2. Drug-free Workplace Policy Responsible Administrative Unit: Human Resources

    E-Print Network [OSTI]

    Drug-free Workplace Policy Responsible Administrative Unit: Human Resources Policy Contact, students, and other individuals in our workplace and campus community. Alcohol abuse and drug use can pose.1 There are many risks associated with the use of illicit drugs and the abuse of alcohol, including physical

  3. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  4. Media's Positive and Negative Frames in Reporting Celebrity Deaths From Illegal Drug Overdoses Versus Prescription Drug Overdoses

    E-Print Network [OSTI]

    Wood, Michelle

    2011-12-31

    This study compared the celebrity illegal drug overdose deaths of River Phoenix, Chris Farley, and Brad Renfro to the prescription drug overdose deaths of Anna Nicole Smith, Heath Ledger, and Brittany Murphy. This research ...

  5. Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes

    E-Print Network [OSTI]

    Chau, Ying

    2005-01-01

    We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

  6. Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating

    E-Print Network [OSTI]

    Zhu, Xiaoxiang, Ph. D. Massachusetts Institute of Technology

    2014-01-01

    Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant ...

  7. Transportation of Hazardous Evidentiary Material.

    SciTech Connect (OSTI)

    Osborn, Douglas.

    2005-06-01

    This document describes the specimen and transportation containers currently available for use with hazardous and infectious materials. A detailed comparison of advantages, disadvantages, and costs of the different technologies is included. Short- and long-term recommendations are also provided.3 DraftDraftDraftExecutive SummaryThe Federal Bureau of Investigation's Hazardous Materials Response Unit currently has hazardous material transport containers for shipping 1-quart paint cans and small amounts of contaminated forensic evidence, but the containers may not be able to maintain their integrity under accident conditions or for some types of hazardous materials. This report provides guidance and recommendations on the availability of packages for the safe and secure transport of evidence consisting of or contaminated with hazardous chemicals or infectious materials. Only non-bulk containers were considered because these are appropriate for transport on small aircraft. This report will addresses packaging and transportation concerns for Hazardous Classes 3, 4, 5, 6, 8, and 9 materials. If the evidence is known or suspected of belonging to one of these Hazardous Classes, it must be packaged in accordance with the provisions of 49 CFR Part 173. The anthrax scare of several years ago, and less well publicized incidents involving unknown and uncharacterized substances, has required that suspicious substances be sent to appropriate analytical laboratories for analysis and characterization. Transportation of potentially hazardous or infectious material to an appropriate analytical laboratory requires transport containers that maintain both the biological and chemical integrity of the substance in question. As a rule, only relatively small quantities will be available for analysis. Appropriate transportation packaging is needed that will maintain the integrity of the substance, will not allow biological alteration, will not react chemically with the substance being shipped, and will otherwise maintain it as nearly as possible in its original condition.The recommendations provided are short-term solutions to the problems of shipping evidence, and have considered only currently commercially available containers. These containers may not be appropriate for all cases. Design, testing, and certification of new transportation containers would be necessary to provide a container appropriate for all cases.Table 1 provides a summary of the recommendations for each class of hazardous material.Table 1: Summary of RecommendationsContainerCost1-quart paint can with ArmlockTM seal ringLabelMaster(r)%242.90 eachHazard Class 3, 4, 5, 8, or 9 Small ContainersTC Hazardous Material Transport ContainerCurrently in Use4 DraftDraftDraftTable 1: Summary of Recommendations (continued)ContainerCost55-gallon open or closed-head steel drumsAll-Pak, Inc.%2458.28 - %2473.62 eachHazard Class 3, 4, 5, 8, or 9 Large Containers95-gallon poly overpack LabelMaster(r)%24194.50 each1-liter glass container with plastic coatingLabelMaster(r)%243.35 - %243.70 eachHazard Class 6 Division 6.1 Poisonous by Inhalation (PIH) Small ContainersTC Hazardous Material Transport ContainerCurrently in Use20 to 55-gallon PIH overpacksLabelMaster(r)%24142.50 - %24170.50 eachHazard Class 6 Division 6.1 Poisonous by Inhalation (PIH) Large Containers65 to 95-gallon poly overpacksLabelMaster(r)%24163.30 - %24194.50 each1-liter transparent containerCurrently in UseHazard Class 6 Division 6.2 Infectious Material Small ContainersInfectious Substance ShipperSource Packaging of NE, Inc.%24336.00 eachNone Commercially AvailableN/AHazard Class 6 Division 6.2 Infectious Material Large ContainersNone Commercially Available N/A5

  8. Transporting Information and Energy Simultaneously

    E-Print Network [OSTI]

    Goyal, Vivek K

    Transporting Information and Energy Simultaneously Lav R. Varshney Laboratory for Information--The fundamental tradeoff between the rates at which energy and reliable information can be transmitted over received energy. A capacity-energy function is defined and a coding theorem is given. The capacity-energy

  9. Memory effects in turbulent transport

    E-Print Network [OSTI]

    Alexander Hubbard; Axel Brandenburg

    2009-11-13

    In the mean-field theory of magnetic fields, turbulent transport, i.e. the turbulent electromotive force, is described by a combination of the alpha effect and turbulent magnetic diffusion, which are usually assumed to be proportional respectively to the mean field and its spatial derivatives. For a passive scalar there is just turbulent diffusion, where the mean flux of concentration depends on the gradient of the mean concentration. However, these proportionalities are approximations that are valid only if the mean field or the mean concentration vary slowly in time. Examples are presented where turbulent transport possesses memory, i.e. where it depends crucially on the past history of the mean field. Such effects are captured by replacing turbulent transport coefficients with time integral kernels, resulting in transport coefficients that depend effectively on the frequency or the growth rate of the mean field itself. In this paper we perform numerical experiments to find the characteristic timescale (or memory length) of this effect as well as simple analytical models of the integral kernels in the case of passive scalar concentrations and kinematic dynamos. The integral kernels can then be used to find self-consistent growth or decay rates of the mean fields. In mean-field dynamos the growth rates and cycle periods based on steady state values of alpha effect and turbulent diffusivity can be quite different from the actual values.

  10. Electrofuels: Versatile Transportation Energy Solutions

    SciTech Connect (OSTI)

    None

    2010-07-01

    Electrofuels Project: ARPA-E’s Electrofuels Project is using microorganisms to create liquid transportation fuels in a new and different way that could be up to 10 times more energy efficient than current biofuel production methods. ARPA-E is the only U.S. government agency currently funding research on Electrofuels.

  11. Sustainable Transportation Energy Pathways Research

    E-Print Network [OSTI]

    Handy, Susan L.

    FUEL/VEHICLE PATHWAYS (ROAD VEH.) #12;Transport Fuels Today (94% petro-based, 2% biofuel) IEA Energy Technology Perspectives (2010) #12;IEA ETP 2012: THREE ENERGY SCENARIOS 6 DS (Current Policies), 4 DS, 2DS Source: IEA Energy Technology Perspectives (2012) #12;MEETING 2050 GHG REDUCTION GOALS => FUEL MIX

  12. Engineering transport by concatenated maps

    E-Print Network [OSTI]

    T. Schell; M. Sadgrove; K. Nakagawa; S. Wimberger

    2013-10-22

    We present a generalized kick rotor model in which the phase of the kick can vary from kick to kick. This additional freedom allows one to control the transport in phase space. For a specific choice of kick-to-kick phases, we predict novel forms of accelerator modes which are potentially of high relevance for future experimental studies.

  13. Saturation and linear transport equation

    E-Print Network [OSTI]

    Krzysztof Kutak

    2009-04-29

    We show that the GBW saturation model provides an exact solution to the one dimensional linear transport equation. We also show that it is motivated by the BK equation considered in the saturated regime when the diffusion and the splitting term in the diffusive approximation are balanced by the nonlinear term.

  14. LouisianaTransportation Research Center

    E-Print Network [OSTI]

    Stephens, Jacqueline

    Transportation and Development and Louisiana State University A.Wave propagation of the pile-energy is generated as the pile and provides technology assistance, engineering training and continuing education, technology transfer) and at the pile tip (5)]; C.Wave p

  15. AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery

    SciTech Connect (OSTI)

    Tsai, Yingssu; McPhillips, Scott E.; González, Ana; McPhillips, Timothy M.; Zinn, Daniel; Cohen, Aina E.; Feese, Michael D.; Bushnell, David; Tiefenbrunn, Theresa; Stout, C. David; Ludaescher, Bertram; Hedman, Britt; Hodgson, Keith O.; Soltis, S. Michael

    2013-05-01

    New software has been developed for automating the experimental and data-processing stages of fragment-based drug discovery at a macromolecular crystallography beamline. A new workflow-automation framework orchestrates beamline-control and data-analysis software while organizing results from multiple samples. AutoDrug is software based upon the scientific workflow paradigm that integrates the Stanford Synchrotron Radiation Lightsource macromolecular crystallography beamlines and third-party processing software to automate the crystallography steps of the fragment-based drug-discovery process. AutoDrug screens a cassette of fragment-soaked crystals, selects crystals for data collection based on screening results and user-specified criteria and determines optimal data-collection strategies. It then collects and processes diffraction data, performs molecular replacement using provided models and detects electron density that is likely to arise from bound fragments. All processes are fully automated, i.e. are performed without user interaction or supervision. Samples can be screened in groups corresponding to particular proteins, crystal forms and/or soaking conditions. A single AutoDrug run is only limited by the capacity of the sample-storage dewar at the beamline: currently 288 samples. AutoDrug was developed in conjunction with RestFlow, a new scientific workflow-automation framework. RestFlow simplifies the design of AutoDrug by managing the flow of data and the organization of results and by orchestrating the execution of computational pipeline steps. It also simplifies the execution and interaction of third-party programs and the beamline-control system. Modeling AutoDrug as a scientific workflow enables multiple variants that meet the requirements of different user groups to be developed and supported. A workflow tailored to mimic the crystallography stages comprising the drug-discovery pipeline of CoCrystal Discovery Inc. has been deployed and successfully demonstrated. This workflow was run once on the same 96 samples that the group had examined manually and the workflow cycled successfully through all of the samples, collected data from the same samples that were selected manually and located the same peaks of unmodeled density in the resulting difference Fourier maps.

  16. Drug testing Example for Conditional Probability and Bayes Theorem Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing Example for Conditional Probability and Bayes Theorem Suppose that a drug test a positive result with probability .98 in the case that the tested individual uses the drug) and 90% accurate not use the drug). Suppose it is known that 10% of the entire population uses this drug. You test someone

  17. Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery

    E-Print Network [OSTI]

    Seto, Jennifer Elizabeth

    2011-01-01

    Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to ...

  18. Transportation Research Record: Journal of the Transportation Research Board, No. 2378, Transportation Research Board of the National Academies, Washington,

    E-Print Network [OSTI]

    Bertini, Robert L.

    to develop trip generation rates for a variety of truck types and land use categories. This research confirms22 Transportation Research Record: Journal of the Transportation Research Board, No. 2378, Transportation Research Board of the National Academies, Washington, D.C., 2013, pp. 22­31. DOI: 10

  19. Transportation Research Record: Journal of the Transportation Research Board, No. 2247, Transportation Research Board of the National Academies, Washington,

    E-Print Network [OSTI]

    Bertini, Robert L.

    24 Transportation Research Record: Journal of the Transportation Research Board, No. 2247, Transportation Research Board of the National Academies, Washington, D.C., 2011, pp. 24­32. DOI: 10 for different types of vehi- cle and bicycle infrastructure is needed to understand how to lower exposures

  20. Life-Cycle Water Impacts of U.S. Transportation Fuels

    E-Print Network [OSTI]

    Scown, Corinne Donahue

    2010-01-01

    refining ? Electricity for transportation, storage, &other water ? Electricity for transportation, storage, &Electricity for extraction, transportation, storage, &

  1. Transportation Data Programs:Transportation Energy Data Book,Vehicle

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCEDInstallers/ContractorsPhotovoltaicsState ofSavingsTransmissionin PEMFC Stacks Transport in

  2. Energy Transport in the Vaidya System

    E-Print Network [OSTI]

    J. P. Krisch; E. N. Glass

    2005-03-21

    Energy transport mechanisms can be generated by imposing relations between null tetrad Ricci components. Several kinds of mass and density transport generated by these relations are studied for the generalized Vaidya system.

  3. Transportation Research Board 94th Annual Meeting

    Broader source: Energy.gov [DOE]

    The Transportation Research Board 94th Annual Meeting will be held January 11–15, 2015, in Washington, D.C. at the Walter E. Washington Convention Center. The event covers the entire transportation...

  4. Long range transport of acid rain precursors

    E-Print Network [OSTI]

    Fay, James A.

    1983-01-01

    A model of the long range transport of primary and secondary pollutants derived by Fay and Rosenzweig (1) is applied to the problem of the transport of acid rain precursors. The model describes the long term average (annual ...

  5. Hydrodynamic phonon transport in suspended graphene

    E-Print Network [OSTI]

    Lee, Sangyeop

    Recent studies of thermal transport in nanomaterials have demonstrated the breakdown of Fourier’s law through observations of ballistic transport. Despite its unique features, another instance of the breakdown of Fourier’s ...

  6. Climatic influences on hillslope soil transport efficiency

    E-Print Network [OSTI]

    Schurr, Naomi D. (Naomi Danika)

    2014-01-01

    The soil transport coefficient D represents the relationship between local topographical gradient and soil flux in the landscape evolution model. This work presents new estimates of the soil transport coefficient D at 9 ...

  7. Geologic selection methodology for transportation corridor routing 

    E-Print Network [OSTI]

    Shultz, Karin Wilson

    2002-01-01

    A lack of planning techniques and processes on long, linear, cut and cover-tunneling route transportation systems has resulted because of the advancement of transportation systems into underground corridors. The proposed methodology is tested...

  8. Particles in Surface Waters: Coagulation and Transport 

    E-Print Network [OSTI]

    Culkin, Gerald W.; Lawler, Desmond F.

    1991-01-01

    -averaged, unsteady particle transport were developed to approximate the size-dependent particle transport processes, which included advection, dispersion, and settling. Coupled exchange of discrete particles between the water column and sediment bed was modeled using...

  9. Hazardous Materials Packaging and Transportation Safety

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-04-20

    The Order establishes safety requirements for the proper packaging and transportation of Department of offsite shipments and onsite transfers of radioactive and other hazardous materials, and for modal transportation.

  10. Rotation generation and transport in tokamak plasmas

    E-Print Network [OSTI]

    Podpaly, Yuri Anatoly

    2012-01-01

    Plasma toroidal rotation is a factor important for plasma stability and transport, but it is still a fairly poorly understood area of physics. This thesis focuses on three aspects of rotation: momentum transport, Ohmic ...

  11. Departmental Materials Transportation and Packaging Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2010-11-18

    Establishes requirements and responsibilities for management of Department of Energy (DOE), including National Nuclear Security Administration, materials transportation and packaging and ensures the safe, secure, efficient packaging and transportation of materials, both hazardous and non-hazardous.

  12. Biofuel Feedstock Inter-Island Transportation

    E-Print Network [OSTI]

    Biofuel Feedstock Inter-Island Transportation Prepared for the U.S. Department of Energy Office Biofuels Feedstocks Hawaii Natural Energy Institute Desktop Study October 2012 Photographs, from left ........................................................................... 11 Options for liquid biofuel feedstock transport ...........................................................................

  13. The Electricity and Transportation Infrastructure Convergence

    E-Print Network [OSTI]

    The Electricity and Transportation Infrastructure Convergence Using Electrical Vehicles Final Project Report Power Systems Engineering Research Center Empowering Minds to Engineer the Future Electric Energy System #12;#12;The Electricity and Transportation Infrastructure Convergence Using Electrical

  14. Decision Models for Bulk Energy Transportation Networks

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    & pipelines · Coal mines & rail/barges · Storage · Electricity market · Electric gen & trans · Costs ... ... Primary Energy Supplies Gas Coal Railroad, Barge ... ... Storage & Transportation Systems Energy Transportation Networks #12;Structural Model: Energy Flows GAS COAL ELECTRIC Case A: 2002

  15. Macrobiotic Vertical Transport of Litter Derived Carbon

    E-Print Network [OSTI]

    Post, Wilfred M.

    Macrobiotic Vertical Transport of Litter Derived Carbon (UPDATE) Mac Callaham Corey Babb Paul vertical transport of litter derived carbon-millipede phase More germane to upland sites Sampled uplands

  16. The Energy Efficiency Potential of Global Transport to 2050 ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The Energy Efficiency Potential of Global Transport to 2050 The Energy Efficiency Potential of Global Transport to 2050 Broad view of sustainability of global transportation...

  17. Transport Study of Three-Dimensional Topological Insulators

    E-Print Network [OSTI]

    Lang, Murong

    2015-01-01

    34. Datta, S. , Electronic transport in mesoscopic systems.47 2.3. Transport Comparison Between Samples with and98 4.3. Transport Measurement of TI/YIG

  18. Table 1. Real Average Transportation and Delivered Costs of Coal...

    U.S. Energy Information Administration (EIA) Indexed Site

    Real Average Transportation and Delivered Costs of Coal, By Year and Primary Transport Mode" "Year","Average Transportation Cost of Coal (Dollars per Ton)","Average Delivered Cost...

  19. Transport Infrastructure and the Environment: Sustainable Mobility and Urbanism

    E-Print Network [OSTI]

    Cervero, Robert

    2013-01-01

    move: a World Bank transport strategy review. Washington:Fulton, l, 2005. Climate change mitigation and transport indeveloping nations’, Transport Reviews, 25(6): 691-717.

  20. Weather and the Transport of Hazardous Materials | Department...

    Office of Environmental Management (EM)

    Weather and the Transport of Hazardous Materials Weather and the Transport of Hazardous Materials Weather and the Transport of Hazardous Materials More Documents & Publications The...

  1. Sandia Energy - Offshore Wind RD&D: Sediment Transport

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sediment Transport Home Stationary Power Energy Conversion Efficiency Wind Energy Offshore Wind Offshore Wind RD&D: Sediment Transport Offshore Wind RD&D: Sediment TransportTara...

  2. Weather and the Transport of Hazardous Materials | Department...

    Office of Environmental Management (EM)

    Weather and the Transport of Hazardous Materials Weather and the Transport of Hazardous Materials Weather and the Transport of Hazardous Materials More Documents & Publications...

  3. Formulation of the Chip Cleanability Mechanics from fluid transport

    E-Print Network [OSTI]

    Garg, Saurabh; Dornfeld, David; Berger, K.

    2009-01-01

    Mechanics from Fluid Transport Author: Garg, Saurabh,Mechanics from fluid transport", International Conference onsimply relying on the fluid transport energy of high

  4. Electrical Transport Properties of Topological Insulators and Graphene

    E-Print Network [OSTI]

    Wang, Zhiyong

    2014-01-01

    OF CALIFORNIA RIVERSIDE Electrical Transport Properties ofABSTRACT OF THE DISSERTATION Electrical Transport Propertiesespecially on the electrical transport studies. There are

  5. Energy, Transportation Ministers from Asia-Pacific Nations Pledge...

    Office of Environmental Management (EM)

    Transportation Ministers from Asia-Pacific Nations Pledge Cooperation on Cleaner, More Energy-Efficient Transportation Energy, Transportation Ministers from Asia-Pacific Nations...

  6. China-Transportation Demand Management in Beijing: Mitigation...

    Open Energy Info (EERE)

    China-Transportation Demand Management in Beijing: Mitigation of Emissions in Urban Transport Jump to: navigation, search Name Transportation Demand Management in Beijing -...

  7. Department of Energy Office of Science Transportation Overview...

    Office of Environmental Management (EM)

    Energy Office of Science Transportation Overview Department of Energy Office of Science Transportation Overview Overview of the Office of Science for Transportation. Department of...

  8. Coherent Structures and Larval Transport in the California Current System

    E-Print Network [OSTI]

    Harrison, Cheryl S.

    2012-01-01

    eddies; ocean transport; California Current 1. Introductionand larval transport in the California Current system CherylEkman transport and pumping in the California Current based

  9. California’s Energy Future: Transportation Energy Use in California

    E-Print Network [OSTI]

    Yang, Christopher

    2011-01-01

    of meeting California’s transportation energy needs andEvidence California’s Energy Future - Transportation Energymarine. California’s Energy Future - Transportation Energy

  10. Vehicle Manufacturing Futures in Transportation Life-cycle Assessment

    E-Print Network [OSTI]

    Chester, Mikhail; Horvath, Arpad

    2011-01-01

    transportation vehicle manufacturing results are developedBERKELEY Vehicle Manufacturing Futures in TransportationAugust 2011 Vehicle Manufacturing Futures in Transportation

  11. Sustainable Transportation Program | ornl.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with government, industry, and academia, Oak Ridge National Laboratory's (ORNL) Sustainable Transportation Program research and development efforts are resulting in...

  12. Wireless Magnetic Sensor Applications in Transportation Infrastructure

    E-Print Network [OSTI]

    Sanchez, Rene Omar

    2012-01-01

    of wireless magnetic sensors in Intelligent Trans- portationof wireless magnetic sensors in Intelligent Transportationmagnetic sensors for different Intelligent Transportation

  13. Dualmode transportation - impact on the electric grid 

    E-Print Network [OSTI]

    Azcarate Lara, Francisco Javier

    2008-10-10

    with numerous challenges including traffic congestion, environmental pollution, safety and energy dependence. Texas particularly, has a challenge to grow transportation capacity at a pace adequate to meet the demand driven by population increases. The Texas... the most cost effective energy source for transportation. Cleaner alternatives do not have access to the transportation market. This thesis follows the style of the Journal of the Transportation Research Record. 2 On the safety front...

  14. Las Cruces MPO 2040 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Las Cruces Metropolitan Planning Organization

    2010-06-09

    /or regionally significant transportation projects determined by the Policy Committee. The list of projects is created in cooperation with residents, local governments, and the New Mexico Department of Transportation (NMDOT). The TIP must be in compliance... short and long-term strategies for maintaining and enhancing the area's transportation system and ? Develop implementation strategies and performance measures that will help achieve the desired results. TRANSPORT 2040 7 ?Y Existing...

  15. Waste Isolation Pilot Plant Transportation Security

    Office of Environmental Management (EM)

    Senior Management Operational Management Implementation OOB NTP Transportation Logistics OSO Operations Management Organization Security WIPP Security Conditions * TRU Waste...

  16. Enhancing Railroad Hazardous Materials Transportation Safety...

    Office of Environmental Management (EM)

    Safety Enhancing Railroad Hazardous Materials Transportation Safety Presented by Kevin R. Blackwell, Radioactive Materials Program Manager. Enhancing Railroad Hazardous Materials...

  17. Reliability of Transport Properties for Bulk Thermoelectrics

    Broader source: Energy.gov [DOE]

    Presents international round-robin study to ensure quality of transport data and figure of merit of thermoelectric materials

  18. A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions

    E-Print Network [OSTI]

    Baral, Chitta

    A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions Jörg, drug efficacy, and drug responses between individuals and sub-populations. Wrong dosages of drugs can lead to severe adverse drug reac- tions in individuals whose drug metabolism drastically differs from

  19. A search for interaction among combinations of drugs of abuse and the use of isobolographic analysis

    E-Print Network [OSTI]

    Obradovic, Zoran

    Commentary A search for interaction among combinations of drugs of abuse and the use: abused drugs, drug combinations, isobole, multi-drug abuse, synergy SUMMARY What is known and Objective: Individuals who abuse drugs usually use more than one substance. Toxic consequences of single and multi-drug

  20. Transport properties in resonant tunneling heterostructures

    E-Print Network [OSTI]

    Presilla, Carlo

    Transport properties in resonant tunneling heterostructures Carlo Presillaa) Dipartimento di Fisica approximation in terms of instantaneous resonances to study the steady-state and time-dependent transport leads, in a natural way, to a transport model of large applicability consisting of reservoirs coupled

  1. A Frequency Analysis of Light Transport

    E-Print Network [OSTI]

    Durand, Frédo

    #12;A Frequency Analysis of Light Transport F. Durand, MIT CSAIL N. Holzschuch, C. Soler, ARTIS lighting onlyDirect lighting only #12;Frequency aspects of light transport · Blurriness = frequency content ­ From equations of light transport #12;Unified framework: · Spatial frequency (e.g. shadows, textures

  2. Demand And Response Transportation Rider's Guide

    E-Print Network [OSTI]

    Acton, Scott

    Demand And Response Transportation Rider's Guide http://www.virginia.edu/parking/disabilities/dart Version 14.5 (8/13/14) Welcome DART Rider: The Demand and Response Transportation (DART) Service rides: #12;Demand And Response Transportation Rider's Guide http

  3. STUDENTS IN TRANSPORTATION ENGINEERING AND PLANNING

    E-Print Network [OSTI]

    Bertini, Robert L.

    STUDENTS IN TRANSPORTATION ENGINEERING AND PLANNING ACTIVITIES SUMMARY FOR FISCAL YEAR 2006 Students in Transportation Engineering and Planning Activities Summary 5. Report Date February 2009 6 Organization Name and Address Students in Transportation Engineering and Planning 10. Work Unit No. (TRAIS) 11

  4. STUDENTS IN TRANSPORTATION ENGINEERING AND PLANNING

    E-Print Network [OSTI]

    Bertini, Robert L.

    STUDENTS IN TRANSPORTATION ENGINEERING AND PLANNING ACTIVITIES SUMMARY FOR FISCAL YEAR 2010 Students in Transportation Engineering and Planning Activities Summary 5. Report Date June 2011 6 Organization Name and Address Students in Transportation Engineering and Planning 10. Work Unit No. (TRAIS) 11

  5. New Methods to Transport Fluids in

    E-Print Network [OSTI]

    Herr, Hugh

    New Methods to Transport Fluids in Micro-Sized Devices Shaun Berry and Jakub Kedzierski control and transport fluid in micro-sized structures presents its own unique set of challenges fluidic operations that are essential to the functionality of the system-- such as fluid transport, mixing

  6. Fluid Neutral Momentum Transport Reference Problem

    E-Print Network [OSTI]

    Budny, Robert

    Fluid Neutral Momentum Transport Reference Problem D. P. Stotler, PPPL S. I. Krasheninnikov, UCSD 1 Summary Type of problem: kinetic or fluid neutral transport Physics or algorithm stressed: thermal force term (spatial resolution) in momentum transport equation and treatment of collisions (charge ex- change

  7. Transport in Dynamical Astronomy and Multibody Problems

    E-Print Network [OSTI]

    Koon, Wang Sang

    Transport in Dynamical Astronomy and Multibody Problems Michael Dellnitz, Oliver Junge, Wang Sang key dynamical features, including almost invariant sets, resonance regions as well as transport rates of these different numerical tools and their applicability. In particular, we compute transport rates between two

  8. A little history of urban transportation

    E-Print Network [OSTI]

    Handy, Susan L.

    ? #12;Density ($) Distance from City Center0 So does lower transportation cost mean steeper or flatter innovation Higher travel speeds Outward expansion Lower densities Greater separation Travel time budget Transportation innovation Outward expansion Outward expansion Transportation innovation #12;Recreational Car Era

  9. Vibration-enhanced quantum transport

    E-Print Network [OSTI]

    F. L. Semião; K. Furuya; G. J. Milburn

    2010-08-17

    In this paper, we study the role of collective vibrational motion in the phenomenon of electronic energy transfer (EET) along a chain of coupled electronic dipoles with varying excitation frequencies. Previous experimental work on EET in conjugated polymer samples has suggested that the common structural framework of the macromolecule introduces correlations in the energy gap fluctuations which cause coherent EET. Inspired by these results, we present a simple model in which a driven nanomechanical resonator mode modulates the excitation energy of coupled quantum dots and find that this can indeed lead to an enhancement in the transport of excitations across the quantum network. Disorder of the on-site energies is a key requirement for this to occur. We also show that in this solid state system phase information is partially retained in the transfer process, as experimentally demonstrated in conjugated polymer samples. Consequently, this mechanism of vibration enhanced quantum transport might find applications in quantum information transfer of qubit states or entanglement.

  10. Generic principles of active transport

    E-Print Network [OSTI]

    Mauro Mobilia; Tobias Reichenbach; Hauke Hinsch; Thomas Franosch; Erwin Frey

    2006-12-20

    Nonequilibrium collective motion is ubiquitous in nature and often results in a rich collection of intringuing phenomena, such as the formation of shocks or patterns, subdiffusive kinetics, traffic jams, and nonequilibrium phase transitions. These stochastic many-body features characterize transport processes in biology, soft condensed matter and, possibly, also in nanoscience. Inspired by these applications, a wide class of lattice-gas models has recently been considered. Building on the celebrated {\\it totally asymmetric simple exclusion process} (TASEP) and a generalization accounting for the exchanges with a reservoir, we discuss the qualitative and quantitative nonequilibrium properties of these model systems. We specifically analyze the case of a dimeric lattice gas, the transport in the presence of pointwise disorder and along coupled tracks.

  11. Transportation Periodicals And Newsletters Currently Received At The Institute Of Transportation Studies Library, University Of California At Berkeley

    E-Print Network [OSTI]

    Hernandez, Paul A.

    2000-01-01

    ERTICO S.C. monthly Estudios de construccion, transportes y1985 - present Estudios de construccion, transportes ybroken file) SPAIN Estudios de construccion, transportes y

  12. Drains Debubbler Transport Liq. Flow

    E-Print Network [OSTI]

    Weber, Rodney

    Drains Debubbler Transport Liq. Flow (LiF) aq. Anion Cation Waste Vacuum Pump LiF H2 O Pure H2 O 1 Denuders Cyclon 16 L/min 2.5 µm cut Sample Tubing ColourFlow, mL/minTubing green/green-1 green/green-2, and Liquid Flow Rates Are Possible Cation: metrosep 2100B-100x4.0mm Eluent: 0.250g/L Dipicolinic acid 1000 u

  13. PNNL Coal Gasifier Transportation Logistics

    SciTech Connect (OSTI)

    Reid, Douglas J.; Guzman, Anthony D.

    2011-04-13

    This report provides Pacific Northwest National laboratory (PNNL) craftspeople with the necessary information and suggested configurations to transport PNNL’s coal gasifier from its current location at the InEnTec facility in Richland, Washington, to PNNL’s Laboratory Support Warehouse (LSW) for short-term storage. A method of securing the gasifier equipment is provided that complies with the tie-down requirements of the Federal Motor Carrier Safety Administration’s Cargo Securement Rules.

  14. Mobility 2035 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Killeen-Temple Urban Transportation Study

    2009-05-20

    braking while decelerating or traveling downhill will be captured with some conversion losses. 9 CHAPTER IV DATA GATHERING To investigate the effect of electrifying existing interstate/freeway transportation, as a start, the existing traffic... on the grid by conveying on the new guideway freight and passenger vehicles currently driven on the freeways and interstate highways. The calculation required total vehicle miles traveled (VMT) and the hourly volume pattern by each vehicle class and road...

  15. Declarative Transport No more transport protocols to design, only policies to specify #

    E-Print Network [OSTI]

    Declarative Transport No more transport protocols to design, only policies to specify # Karim ABSTRACT Transport protocols are an integral part of the inter­process communication (IPC) service used on transport, one would have hoped that we have a good handle on the problem. Unfortunately, that is not true

  16. Declarative Transport No more transport protocols to design, only policies to specify

    E-Print Network [OSTI]

    Declarative Transport No more transport protocols to design, only policies to specify Karim Mattar Transport protocols are an integral part of the inter-process communication (IPC) service used on transport, one would have hoped that we have a good handle on the problem. Unfortunately, that is not true

  17. TRANSPORTATION ENERGY DATA BOOK: EDITION 34--2015 TRANSPORTATION ENERGY DATA BOOK: EDITION 34--2015

    E-Print Network [OSTI]

    Pennycook, Steve

    C­1 TRANSPORTATION ENERGY DATA BOOK: EDITION 34--2015 APPENDIX C MAPS #12;C­2 TRANSPORTATION ENERGY DATA BOOK: EDITION 34--2015 #12;C­3 TRANSPORTATION ENERGY DATA BOOK: EDITION 34--2015 Table C.1 Census Illinois Indiana Michigan Ohio Wisconsin Source: U.S. Census Bureau. #12;C­4 TRANSPORTATION ENERGY DATA

  18. Title: Drug and Alcohol Policies --Drug-Free Workplace Code: 1-300-020

    E-Print Network [OSTI]

    Huang, Jianyu

    -free workplace, and, in the case of grantees who are individuals, by requiring each individual to certify to receiving a contract or grant from a federal agency. All grantees who fail to meet the drug-free workplace of the Act. Grantees are not required to make a certification in order to continue receiving funds under

  19. transportation

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal GasAdministration Medal01 Sandia4)9 FederalRivers andMEDA Station3/%2A ¡

  20. Method and apparatus for transporting liquid slurries

    DOE Patents [OSTI]

    Berry, G.F.; Lyczkowski, R.W.; Chisheng Wang.

    1993-03-16

    An improved method and device to prevent erosion of slurry transport devices is disclosed which uses liquid injection to prevent contact by the slurry composition with the inner surface of the walls of the transport system. A non-abrasive liquid is injected into the slurry transport system and maintains intimate contact with the entire inner surface of the transport system, thereby creating a fluid barrier between the non-abrasive liquid and the inner surface of the transport system which thereby prevents erosion.

  1. An Analysis of the Impacts of British Transport Reforms on Transit Integration in the Metropolitan Areas

    E-Print Network [OSTI]

    Rivasplata, Charles Richard

    2006-01-01

    dares – the London experience, Transportation Planning anddecisions, Transportation 27: 243-267. London Transport (transportation, Mass Transit (November). Transport for London (

  2. TEXAS TRANSPORTATION INSTITUTE THE TEXAS A&M UNIVERSITY SYSTEM

    E-Print Network [OSTI]

    .Sc. Center for Sustainable Mobility, Virginia Tech Transportation Institute 3500 Transportation ResearchD. Center for Sustainable Mobility, Virginia Tech Transportation Institute 3500 Transportation Research) NOx Emissions Testing Expanding MOBILE6 Rates to Accommodate High Speeds Sponsored By Houston Advanced

  3. Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance

    SciTech Connect (OSTI)

    Mickisch, G.H.; Merlino, G.T.; Galski, H.; Gottesman, M.M.; Pastan, I. )

    1991-01-15

    The development of preclinical models for the rapid testing of agents that circumvent multidrug resistance in cancer is a high priority of research on drug resistance. A common form of multidrug resistance in human cancer results from expression of the MDR1 gene, which encodes a M{sub r} 170,000 glycoprotein that functions as a plasma membrane energy-dependent multidrug efflux pump. The authors have engineered transgenic mice that express this multidrug transporter in their bone marrow and demonstrated that these animals are resistant to leukopenia by a panel of anticancer drugs including anthracyclines, vinca alkaloids, etoposide, taxol, and actinomycin D. Differential leukocyte counts indicate that both neutrophils and lympohcytes are pretected. Drugs such as cisplatin, methotrexate, and 5-fluorouracil, which are not handled by the multidrug transporter, produce bone marrow suppression in both normal and transgenic mice. The resistance conferred by the MDR1 gene can be circumvented in a dose-dependent manner by simultaneous administration of agents previously shown to be inhibitors of the multidrug transporter in vitro, including verapamil isomers, quinidine, and quinine. They conclude that MDR1-transgenic mice provide a rapid and reliable system to determine the bioactivity of agents that reverse multidrug resistance in animals.

  4. Utah Clean Cities Transportation Sector Petroleum Reduction Technologi...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    More Documents & Publications Utah Clean Cities Transportation Sector Petroleum Reduction Technologies Program Utah Clean Cities Transportation Sector Petroleum...

  5. Promoting a Green Economy through Clean Transportation Alternatives...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Documents & Publications Promoting a Green Economy through Clean Transportation Alternatives Promoting a Green Economy through Clean Transportation Alternatives EV Community...

  6. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Print Type 2 diabetes mellitus (T2DM), characterized by abnormally high blood glucose levels, affects hundreds of millions of...

  7. Intratumor heterogeneity alters most effective drugs in designed combinations

    E-Print Network [OSTI]

    Zhao, Boyang

    The substantial spatial and temporal heterogeneity observed in patient tumors poses considerable challenges for the design of effective drug combinations with predictable outcomes. Currently, the implications of tissue ...

  8. Nobel Laureate speaks on antibiotics and drug resistance | ornl...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nobel Laureate speaks on antibiotics and drug resistance Ramakrishnan cited several pioneers of antibiotic research in his talk. Ramakrishnan cited several pioneers of antibiotic...

  9. Cellulose, Chitosan, and Keratin Composite Materials. Controlled Drug Release

    E-Print Network [OSTI]

    Reid, Scott A.

    Cellulose, Chitosan, and Keratin Composite Materials. Controlled Drug Release Chieu D. Tran 53201, United States *S Supporting Information ABSTRACT: A method was developed in which cellulose (CEL

  10. Food and Drug Administration White Oak Campus Environmental Stewardshi...

    Energy Savers [EERE]

    Stewardship and Cost Savings FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus. PDF icon...

  11. In silico modeling to predict drug-induced phospholipidosis

    SciTech Connect (OSTI)

    Choi, Sydney S.; Kim, Jae S.; Valerio, Luis G., E-mail: luis.valerio@fda.hhs.gov; Sadrieh, Nakissa

    2013-06-01

    Drug-induced phospholipidosis (DIPL) is a preclinical finding during pharmaceutical drug development that has implications on the course of drug development and regulatory safety review. A principal characteristic of drugs inducing DIPL is known to be a cationic amphiphilic structure. This provides evidence for a structure-based explanation and opportunity to analyze properties and structures of drugs with the histopathologic findings for DIPL. In previous work from the FDA, in silico quantitative structure–activity relationship (QSAR) modeling using machine learning approaches has shown promise with a large dataset of drugs but included unconfirmed data as well. In this study, we report the construction and validation of a battery of complementary in silico QSAR models using the FDA's updated database on phospholipidosis, new algorithms and predictive technologies, and in particular, we address high performance with a high-confidence dataset. The results of our modeling for DIPL include rigorous external validation tests showing 80–81% concordance. Furthermore, the predictive performance characteristics include models with high sensitivity and specificity, in most cases above ? 80% leading to desired high negative and positive predictivity. These models are intended to be utilized for regulatory toxicology applied science needs in screening new drugs for DIPL. - Highlights: • New in silico models for predicting drug-induced phospholipidosis (DIPL) are described. • The training set data in the models is derived from the FDA's phospholipidosis database. • We find excellent predictivity values of the models based on external validation. • The models can support drug screening and regulatory decision-making on DIPL.

  12. Certificate in Transit Management and

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    , and perform minor maintenance and staff responsibilities. UMass Transit has been a fare free public transit operation, and management. CTTransit CEE 310 Intro to Transportation Systems FINOPMGT 341 Logistics

  13. Top transport in electroweak baryogenesis

    E-Print Network [OSTI]

    Lars Fromme; Stephan J. Huber

    2006-05-09

    In non-supersymmetric models of electroweak baryogenesis the top quark plays a crucial role. Its CP-violating source term can be calculated in the WKB approximation. We point out how to resolve certain discrepancies between computations starting from the Dirac equation and the Schwinger--Keldysh formalism. We also improve on the transport equations, keeping the W-scatterings at finite rate. We apply these results to a model with one Higgs doublet, augmented by dimension-6 operators, where our refinements lead to an increase in the baryon asymmetry by a factor of up to about 5.

  14. Methods of making transportation fuel

    DOE Patents [OSTI]

    Roes, Augustinus Wilhelmus Maria (Houston, TX); Mo, Weijian (Sugar Land, TX); Muylle, Michel Serge Marie (Houston, TX); Mandema, Remco Hugo (Houston, TX); Nair, Vijay (Katy, TX)

    2012-04-10

    A method for producing alkylated hydrocarbons is disclosed. Formation fluid is produced from a subsurface in situ heat treatment process. The formation fluid is separated to produce a liquid stream and a first gas stream. The first gas stream includes olefins. The liquid stream is fractionated to produce at least a second gas stream including hydrocarbons having a carbon number of at least 3. The first gas stream and the second gas stream are introduced into an alkylation unit to produce alkylated hydrocarbons. At least a portion of the olefins in the first gas stream enhance alkylation. The alkylated hydrocarbons may be blended with one or more components to produce transportation fuel.

  15. Analysis of RADTRAN transportation model

    SciTech Connect (OSTI)

    Resnikoff, M. [Radioactive Waste Management Associates, New York, NY (United States)

    1990-10-01

    This paper reviews the RADTRAN computer model, used to estimate the risks of transporting waste to a high-level repository. Ignoring high consequence accidents, human error, sabotage, realistic accident scenarios and recent health effects data leads to an underestimate of potential health effects. Potential economic costs following an accident in a rural area are low compared to a scale-up of the Palomares, Spain clean-up and other estimates. The author states that these costs can vary widely depending on the accident locale and whether certain direct and indirect costs are included.

  16. Badger Transport | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar Energy LLC Jump to:Greece: EnergyMontana)DistrictTransport Jump to:

  17. SATURATED ZONE FLOW AND TRANSPORT MODEL ABSTRACTION

    SciTech Connect (OSTI)

    B.W. ARNOLD

    2004-10-27

    The purpose of the saturated zone (SZ) flow and transport model abstraction task is to provide radionuclide-transport simulation results for use in the total system performance assessment (TSPA) for license application (LA) calculations. This task includes assessment of uncertainty in parameters that pertain to both groundwater flow and radionuclide transport in the models used for this purpose. This model report documents the following: (1) The SZ transport abstraction model, which consists of a set of radionuclide breakthrough curves at the accessible environment for use in the TSPA-LA simulations of radionuclide releases into the biosphere. These radionuclide breakthrough curves contain information on radionuclide-transport times through the SZ. (2) The SZ one-dimensional (I-D) transport model, which is incorporated in the TSPA-LA model to simulate the transport, decay, and ingrowth of radionuclide decay chains in the SZ. (3) The analysis of uncertainty in groundwater-flow and radionuclide-transport input parameters for the SZ transport abstraction model and the SZ 1-D transport model. (4) The analysis of the background concentration of alpha-emitting species in the groundwater of the SZ.

  18. Regulatory aspects of oncology drug safety evaluation: Past practice, current issues, and the challenge of new drugs

    SciTech Connect (OSTI)

    Rosenfeldt, Hans; Kropp, Timothy; Benson, Kimberly; Ricci, M. Stacey; McGuinn, W. David; Verbois, S. Leigh

    2010-03-01

    The drug development of new anti-cancer agents is streamlined in response to the urgency of bringing effective drugs to market for patients with limited life expectancy. FDA's regulation of oncology drugs has evolved from the practices set forth in Arnold Lehman's seminal work published in the 1950s through the current drafting of a new International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) safety guidance for anti-cancer drug nonclinical evaluations. The ICH combines the efforts of the regulatory authorities of Europe, Japan, and the United States and the pharmaceutical industry from these three regions to streamline the scientific and technical aspects of drug development. The recent development of new oncology drug classes with novel mechanisms of action has improved survival rates for some cancers but also brings new challenges for safety evaluation. Here we present the legacy of Lehman and colleagues in the context of past and present oncology drug development practices and focus on some of the current issues at the center of an evolving harmonization process that will generate a new safety guidance for oncology drugs, ICH S9. The purpose of this new guidance will be to facilitate oncology drug development on a global scale by standardizing regional safety requirements.

  19. Spin Transport in Semiconductor heterostructures

    SciTech Connect (OSTI)

    Domnita Catalina Marinescu

    2011-02-22

    The focus of the research performed under this grant has been the investigation of spin transport in magnetic semiconductor heterostructures. The interest in these systems is motivated both by their intriguing physical properties, as the physical embodiment of a spin-polarized Fermi liquid, as well as by their potential applications as spintronics devices. In our work we have analyzed several different problems that affect the spin dynamics in single and bi-layer spin-polarized two-dimensional (2D) systems. The topics of interests ranged from the fundamental aspects of the electron-electron interactions, to collective spin and charge density excitations and spin transport in the presence of the spin-orbit coupling. The common denominator of these subjects is the impact at the macroscopic scale of the spin-dependent electron-electron interaction, which plays a much more subtle role than in unpolarized electron systems. Our calculations of several measurable parameters, such as the excitation frequencies of magneto-plasma modes, the spin mass, and the spin transresistivity, propose realistic theoretical estimates of the opposite-spin many-body effects, in particular opposite-spin correlations, that can be directly connected with experimental measurements.

  20. MSIV leakage airborne iodine transport

    SciTech Connect (OSTI)

    Cline, J.E. (Cline Associates Inc., Rockville, MD (United States))

    1993-01-01

    Gaseous iodine deposits on surfaces exposed to vapors. Basic chemical and physical principles predict this behavior, and several laboratory and in-plant measurements demonstrate the characteristic. An empirical model was developed that describes the deposition, resuspension, and transformation of airborne radioiodine molecular species as a stream containing these forms moves along its pathway. The model uses a data base of measured values of deposition and resuspension rates in its application and describes the conversion of the more reactive inorganic iodine species I[sub 2] to the less reactive organic species CH[sub 3]I as the iodine deposits and resuspends along the path. It also considers radioactive decay and chemical surface bonding during residence on surfaces. For the 8-day [sup 131]I, decay during the airborne portion of the transport is negligible. Verification of the model included measurement tests of long gaseous-activity sampling lines of different diameters, operated at different flow rates and stream temperatures. The model was applied to the streams at a boiling water reactor nuclear power plant to describe the transport through leaking main steam isolation valves (MSIVs), following a loss-of-coolant accident.

  1. Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient

    E-Print Network [OSTI]

    Hinow, Peter

    Summary Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient powders variation in the drug release profile of the tablet. While fabrication of experimental tablets

  2. Environment Assisted Quantum Transport in Organic Molecules

    E-Print Network [OSTI]

    Vattay, Gabor

    2015-01-01

    One of the new discoveries in quantum biology is the role of Environment Assisted Quantum Transport (ENAQT) in excitonic transport processes. In disordered quantum systems transport is most efficient when the environment just destroys quantum interferences responsible for localization, but the coupling does not drive the system to fully classical thermal diffusion yet. This poised realm between the pure quantum and the semi-classical domains has not been considered in other biological transport processes, such as charge transport through organic molecules. Binding in receptor-ligand complexes is assumed to be static as electrons are assumed to be not able to cross the ligand molecule. We show that ENAQT makes cross ligand transport possible and efficient between certain atoms opening the way for the reorganization of the charge distribution on the receptor when the ligand molecule docks. This new effect can potentially change our understanding how receptors work. We demonstrate room temperature ENAQT on the c...

  3. Ordered transport and identification of particles

    DOE Patents [OSTI]

    Shera, E.B.

    1993-05-11

    A method and apparatus are provided for application of electrical field gradients to induce particle velocities to enable particle sequence and identification information to be obtained. Particle sequence is maintained by providing electroosmotic flow for an electrolytic solution in a particle transport tube. The transport tube and electrolytic solution are selected to provide an electroosmotic radius of >100 so that a plug flow profile is obtained for the electrolytic solution in the transport tube. Thus, particles are maintained in the same order in which they are introduced in the transport tube. When the particles also have known electrophoretic velocities, the field gradients introduce an electrophoretic velocity component onto the electroosmotic velocity. The time that the particles pass selected locations along the transport tube may then be detected and the electrophoretic velocity component calculated for particle identification. One particular application is the ordered transport and identification of labeled nucleotides sequentially cleaved from a strand of DNA.

  4. Transportation Energy Data Book, Edition 18

    SciTech Connect (OSTI)

    Davis, Stacy C.

    1998-09-01

    The Transportation Energy Data Book: Edition 18 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. This edition of the Data Book has 11 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 - energy Chapter 3 - emissions; Chapter 4 - transportation and the economy; Chapter 5 - highway vehicles; Chapter 6 - Light vehicles; Chapter 7 - heavy vehicles; Chapter 8 - alternative fuel vehicles; Chapter 9 - fleet vehicles; Chapter 10 - household vehicles; and Chapter 11 - nonhighway modes. The sources used represent the latest available data.

  5. Transportation Safety Excellence in Operations Through Improved Transportation Safety Document

    SciTech Connect (OSTI)

    Dr. Michael A. Lehto; MAL

    2007-05-01

    A recent accomplishment of the Idaho National Laboratory (INL) Materials and Fuels Complex (MFC) Nuclear Safety analysis group was to obtain DOE-ID approval for the inter-facility transfer of greater-than-Hazard-Category-3 quantity radioactive/fissionable waste in Department of Transportation (DOT) Type A drums at MFC. This accomplishment supported excellence in operations through safety analysis by better integrating nuclear safety requirements with waste requirements in the Transportation Safety Document (TSD); reducing container and transport costs; and making facility operations more efficient. The MFC TSD governs and controls the inter-facility transfer of greater-than-Hazard-Category-3 radioactive and/or fissionable materials in non-DOT approved containers. Previously, the TSD did not include the capability to transfer payloads of greater-than-Hazard-Category-3 radioactive and/or fissionable materials using DOT Type A drums. Previous practice was to package the waste materials to less-than-Hazard-Category-3 quantities when loading DOT Type A drums for transfer out of facilities to reduce facility waste accumulations. This practice allowed operations to proceed, but resulted in drums being loaded to less than the Waste Isolation Pilot Plant (WIPP) waste acceptance criteria (WAC) waste limits, which was not cost effective or operations friendly. An improved and revised safety analysis was used to gain DOE-ID approval for adding this container configuration to the MFC TSD safety basis. In the process of obtaining approval of the revised safety basis, safety analysis practices were used effectively to directly support excellence in operations. Several factors contributed to the success of MFC’s effort to obtain approval for the use of DOT Type A drums, including two practices that could help in future safety basis changes at other facilities. 1) The process of incorporating the DOT Type A drums into the TSD at MFC helped to better integrate nuclear safety requirements with waste requirements. MFC’s efforts illustrate that utilizing the requirements of other disciplines, beyond nuclear safety, can provide an efficient process. Analyzing current processes to find better ways of meeting the requirements of multiple disciplines within a safety basis can lead to a more cost-effective, streamlined process. 2) Incorporating the DOT Type A drums into the MFC TSD was efficient because safety analysts utilized a transportation plan that provided analysis that could also be used for the change to the TSD addendum. In addition, because the plan they used had already been approved and was in use by the Idaho Cleanup Project (ICP) at the INL, justification for the change to the TSD was more compelling. MFC safety analysts proved that streamlining a process can be made more feasible by drawing from analysis that has already been completed.

  6. Revealing the paradox of drug reward in human evolution

    E-Print Network [OSTI]

    ; Nestler 2005). Most commonly used psychoactive drugs are plant secondary metabolites (e.g. alkaloids secondary metabolites, including alkaloids such as nicotine, morphine and cocaine, are potent neurotoxins. However, the most commonly used drugs are plant neurotoxins that evolved to punish, not reward

  7. Drug-Free Federal Workplace Testing Implementation Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-06

    The subject directive provides requirements and responsibilities for the implementation of a workplace program to test for the use of illegal drugs to facilitate the maintenance of a drug-free Federal workplace. In the course of the revision, the document number will change from DOE O 3792.3 to DOE O 343.1.

  8. Experimental Models of Anxiety for Drug Discovery and Brain Research

    E-Print Network [OSTI]

    Kalueff, Allan V.

    Chapter 18 Experimental Models of Anxiety for Drug Discovery and Brain Research Peter C. Hart and anxiogenic drugs. Detailed protocols will be provided for these paradigms, and possible confounds+Business Media, LLC 2010 299 #12;300 Hart et al. It is important to understand, however, that any animal exper

  9. Alternative Breaks Alcohol and Drug Policy 2014-2015

    E-Print Network [OSTI]

    Tipple, Brett

    Alternative Breaks Alcohol and Drug Policy 2014-2015 In order to promote personal development order and stability on Alternative Break trips, the following standards concerning drug and alcohol use have been set and will be enforced on all Alternative Break trips: 1. Use, possession or distribution

  10. Transport and Dissipation in Quantum Pumps

    E-Print Network [OSTI]

    J. E. Avron; A. Elgart; G. M. Graf; L. Sadun

    2003-05-23

    This paper is about adiabatic transport in quantum pumps. The notion of ``energy shift'', a self-adjoint operator dual to the Wigner time delay, plays a role in our approach: It determines the current, the dissipation, the noise and the entropy currents in quantum pumps. We discuss the geometric and topological content of adiabatic transport and show that the mechanism of Thouless and Niu for quantized transport via Chern numbers cannot be realized in quantum pumps where Chern numbers necessarily vanish.

  11. Enhancing Railroad Hazardous Materials Transportation Safety...

    Office of Environmental Management (EM)

    Safety Rail Routing Enhancing Railroad Hazardous Materials Transportation Safety Rail Routing Presentation made by Kevin Blackwell for the NTSF annual meeting held from May 14-16,...

  12. "Multiscale Capabilities for Exploring Transport Phenomena in...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: "Multiscale Capabilities for Exploring Transport Phenomena in Batteries": Ab Initio Calculations on Defective LiFePO4 Citation Details In-Document Search Title:...

  13. Parallel Transport on Principal Bundles over Stacks

    E-Print Network [OSTI]

    Brian Collier; Eugene Lerman; Seth Wolbert

    2015-09-16

    In this paper we introduce a notion of parallel transport for principal bundles with connections over differentiable stacks. We show that principal bundles with connections over stacks can be recovered from their parallel transport thereby extending the results of Barrett, Caetano and Picken, and Schreiber and Waldof from manifolds to stacks. In the process of proving our main result we simplify Schreiber and Waldorf's definition of a transport functor for principal bundles with connections over manifolds and provide a more direct proof of the correspondence between principal bundles with connections and transport functors.

  14. SOLVING POWER-CONSTRAINED GAS TRANSPORTATION ...

    E-Print Network [OSTI]

    2014-11-27

    Nov 27, 2014 ... pressure and the mass flow at supply and demand nodes. Using mass flow ...... Modeling of Oil Product and Gas Pipeline Transportation. Wein-.

  15. DOE-Idaho's Packaging and Transportation Perspective

    Office of Environmental Management (EM)

    Idaho's Packaging and T t ti P ti Transportation Perspective Richard Provencher Manager DOE Idaho Operations Office DOE Idaho Operations Office Presented to the DOE National...

  16. Transportation in Community Strategic Energy Plans

    Broader source: Energy.gov [DOE]

    This presentation features Caley Johnson, a fuel and vehicle market analyst with the National Renewable Energy Laboratory. Johnson provides an overview of how and why to incorporate transportation...

  17. Transportation Energy Futures: Combining Strategies for Deep...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ENERGY FUTURES Combining Strategies for Deep Reductions in Energy Consumption and GHG Emissions Significant Energy Consumption - and Opportunities for Reduction Transportation is...

  18. Reducing Emissions Through Sustainable Transport: Proposal for...

    Open Energy Info (EERE)

    Reducing Emissions Through Sustainable Transport: Proposal for a Sectoral Approach Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Reducing Emissions Through Sustainable...

  19. Coal Transportation Issues (released in AEO2007)

    Reports and Publications (EIA)

    2007-01-01

    Most of the coal delivered to U.S. consumers is transported by railroads, which accounted for 64% of total domestic coal shipments in 2004. Trucks transported approximately 12% of the coal consumed in the United States in 2004, mainly in short hauls from mines in the East to nearby coal-fired electricity and industrial plants. A number of minemouth power plants in the West also use trucks to haul coal from adjacent mining operations. Other significant modes of coal transportation in 2004 included conveyor belt and slurry pipeline (12%) and water transport on inland waterways, the Great Lakes, and tidewater areas (9%).

  20. Electrical and Thermoelectrical Transport Properties of Graphene

    E-Print Network [OSTI]

    Wang, Deqi

    2011-01-01

    IV Large Memory Effect in Graphene Based Devices IV-1Transport Properties of Graphene A Dissertation submitted into study the new material, graphene. By investigating the