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Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Liposomal Vincristine Which Exhibits Increased Drug Retention and Increased Circulation Longevity Cures Mice Bearing P388 Tumors  

Science Journals Connector (OSTI)

...tumor models (9). Four mice were used per time point. The mice were anesthetized...the circulation half-lift of vincristine from approximately...retention. At every time point, .@. 0 0 a a. :3...the mean using at least four mice. higher drug...

Nancy L. Boman; Dana Masin; Lawrence D. Mayer; Pieter R. Cullis; and Marcel B. Bally

1994-06-01T23:59:59.000Z

2

Use of rare earth elements as external markers for mean retention time measurements in ruminants  

E-Print Network (OSTI)

Review Use of rare earth elements as external markers for mean retention time measurements -- The present review deals with the utilisation of rare earth (RE) elements as particulate markers for ruminant earth / retention time / feedstuff / methodology / ruminant Résumé -- Utilisation des terres rares comme

Paris-Sud XI, Université de

3

QSPR models of boiling point, octanolwater partition coefficient and retention time index of polycyclic aromatic hydrocarbons  

E-Print Network (OSTI)

QSPR models of boiling point, octanol­water partition coefficient and retention time index of polycyclic aromatic hydrocarbons Fabiana Alves de Lima Ribeiro, Ma´rcia Miguel Castro Ferreira* Laborato Structure­Property Relationship (QSPR) analysis and study of polycyclic aromatic hydrocarbons (PAHs

Ferreira, Márcia M. C.

4

The effect of solids retention time on tertiary ozonation and carbon adsorption of petrochemical wastewaters  

E-Print Network (OSTI)

and biochemical oxygen demands were measured before and after ozaontion as well as the amount of ozone consumed. Non-adsorbable COD was measured and a comparison of ozonized and unozonized wastewater made. BOD concentration rose after ozonation, but decreased... of solids retention time on nonadsorbable COD, with and without ozonation. 39 LIST OF TABLES Table Page Biochemical and chemical oxygen demand data. COD removal and ozone consumption data 21 26 iVon-adsorbable COD data for bio-oxidized effluent. . 3O...

Buys, Ronald Earl

2012-06-07T23:59:59.000Z

5

174. THE EFFECTS OF RESIDENCE TIME ON THE RETENTION OF ARSENATE BY GOETHITE. S.E. O'Reilly and D.L. Sparks, Department of Plant and Soil Sciences, University  

E-Print Network (OSTI)

174. THE EFFECTS OF RESIDENCE TIME ON THE RETENTION OF ARSENATE BY GOETHITE. S.E. O'Reilly and D on goethite. Batch sorption and desorption studies were conducted at pH 6 for periods up to 2 months. Arsenate sorption increased slowly with time. As residence time between arsenate and goethite increased

Sparks, Donald L.

6

Ultrasonic sludge disintegration for enhanced methane production in anaerobic digestion: effects of sludge hydrolysis efficiency and hydraulic retention time  

Science Journals Connector (OSTI)

Hydrolysis of waste activated sludge (WAS) has been regarded as the rate limiting step of anaerobic sludge digestion. Therefore, in this study, the ... effect of ultrasound and hydraulic residence time during sludge

Dong-Jin Kim; Jonghak Lee

2012-01-01T23:59:59.000Z

7

E-Print Network 3.0 - affects mibg retention Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

constipation, functional fecal retention, and non-retentive fecal soiling. A... time. Boys and girls are equally affected. 12;Infant Dyschezia Dyschezia ... Source: Louisiana...

8

Coatings for performance retention  

Science Journals Connector (OSTI)

Performance and performance retention are becoming increasingly important in todays gas turbine engines. The military aircraft engine operator wants the flexibility and flight envelope that increased performance will give and the commercial useraircraft utility generation or pumperdemands the long term fuel economy that improved performance retention will provide. Materials advances have provided the intrinsic strength and temperature increases to push the capability of todays engines and coatings have been an integral part of that advancement. Specifically in the performance retention area coatings and seal systems have become increasingly important in both compressor and turbine components. It is the intent of this overview paper to present a brief review of the coating systems presently in use and in development and to consider areas in which the technology might be heading.

R. V. Hillery

1986-01-01T23:59:59.000Z

9

Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http://www.robotic-lab.com/en/2011/04/22/nanotechnology-boosts-anticancer-drug-cocktail-many-times-over/[5/2/2011 12:11:22 PM  

E-Print Network (OSTI)

Robotic-Lab.COM » Nanotechnology boosts anticancer drug cocktail many times over http://www.robotic-lab.com/en/2011/04/22/nanotechnology-boosts-anticancer-drug-cocktail-many-times-over/[5/2/2011 12:11:22 PM] Nanotechnology boosts anticancer drug cocktail many times over Writte by Jim Lewis the 22/04/2011 Using

Brinker, C. Jeffrey

10

Work Force Retention Work Group Charter  

Energy.gov (U.S. Department of Energy (DOE))

The Work force Retention Work Group is established to support the Departments critical focus on maintaining a high-performing work force at a time when a significant number of the workers needed to support DOEs national security mission are reaching retirement age.

11

Drug Detection Study  

Office of Scientific and Technical Information (OSTI)

ORISE-07-NSEM-0544 ORISE-07-NSEM-0544 U.S. Department of Energy Office of Health, Safety and Security Office of Security Policy Drug Retention Times Center for Human Reliability Studies Oak Ridge Institute for Science and Education Operated by Oak Ridge Associated Universities For the U.S. Department of Energy Oak Ridge Associated Universities (ORAU) is a university consortium leveraging the scientific strength of major research institutions to advance science and education by partnering with national laboratories, government agencies, and private industry. ORAU manages the Oak Ridge Institute for Science and Education for the U.S. Department of Energy. The Oak Ridge Institute for Science and Education (ORISE) is a U.S. Department of Energy institute focusing on

12

Real-time electrochemical monitoring of drug release from therapeutic nanoparticles Laura Mora a,c  

E-Print Network (OSTI)

both academic and industrial investigators in the past two decades because of its many favorable, liposomes, solid lipid NPs, polymeric NPs, dendrimers, silica NPs, and nanoemulsions [3,4]. For all desirable for obtaining reliable assessment of the drug release kinetics. While several analytical

Zhang, Liangfang

13

Workforce Retention | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Services » Outreach & Collaboration » Focus Groups » Workforce Services » Outreach & Collaboration » Focus Groups » Workforce Retention Workforce Retention The HSS Workforce Retention Work Group was established to collaboratively address the needs of the Department to maintain a skilled work force in the face of anticipated retirements and to address the specific health and safety concerns of that work force that could impede retention. Objectives: Better understand relationship between skilled workforce retention; health, safety and productivity; and especially preventive health care. Inform and support improvement and/or development of wellness, fitness, and prevention programs through data collections and analyses. Promote the implementation of preventive health services designed to assure retention of the contractor work force.

14

Protections: Sediment Control = Contaminant Retention  

NLE Websites -- All DOE Office Websites (Extended Search)

Sediment Control Protections: Sediment Control Contaminant Retention LANL maintains hundreds of wells, stream sampling stations and stormwater control structures to protect...

15

Residence Time Effects on P Sorption/Desorption on Ferrihydrite Understanding mechanisms of P retention/release on soil mineral surfaces is  

E-Print Network (OSTI)

Residence Time Effects on P Sorption/Desorption on Ferrihydrite Y. Arai Understanding mechanisms through macroscopic and microscopic approaches. The effect of ionic strength (0.0, 0.1, 1.0) on P sorption pH, sorption decreased ad I decreased. The effect of pH (4, 7.l5, 9.5) on P sorption kinetics

Sparks, Donald L.

16

Relative Retention Data for an Ethofat Column  

Science Journals Connector (OSTI)

......Retention Data for an Ethofat Column David P. Mowry Marathon Oil Company, Littleton, Colorado 80121 ture. RECIPROCAL...Retention Data for an Ethofat Column by David P. Mowry, Marathon 011 Company, Littleton, Colorado 80121 Relative retention......

David P. Mowry

1966-11-01T23:59:59.000Z

17

Technetium Retention During LAW Vitrification  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Technetium Retention During Technetium Retention During LAW Vitrification Ian L. Pegg Vitreous State Laboratory The Catholic University of America Washington, DC November 18, 2010 Overview * Tc in borosilcate glass structure * Re as a surrogate for Tc * Summary of previous data on Tc incorporation into LAW glass * Summary of results from ongoing test program * Single-pass retention vs. retention with recycle * Tc volatilization during container filling Tc in LAW Glass Structure * Tc is present as Tc 7+ and Tc 4+ * Tc 7+ is dominant in more oxidized glasses and Tc 4+ is dominant in reduced glasses * Strongly reducing conditions produce Tc 0 * The structure and local environment of Tc in WTP LAW glasses has been investigated by: * Synchrotron X-Ray Absorption Spectroscopy * Lukens, McKeown, Buechele, Muller, Shuh, and Pegg, Chem. Mater., 19, 559 (2007)

18

July 2012, Work Force Retention Work Group Status Overview  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Work Force Retention Work Group Status Overview Work Force Retention Work Group Status Overview Accomplishments: 1. Progress on the completion of the 10 CFR 1046 modifications to address barriers to workforce retention. Written response to public comment is being drafted by HS-51. 2. Pro-Force (PF) union representative, Randy Lawson, identified this accomplishment as the single most significant step toward PF workforce retention in over 20 years. 3. Draft re-charter of PF Career Options Committee (PFCOC) to establish a PF Working Group approved by GC-63 and GC NNSA. Near Term Goals and Activities: 1. Publish 1046 as a final rule - anticipated completion no later than September, assuming timely OMB review and approval. 2. Draft PF Working Group charter final review by senior management to be

19

Neutron crystallography aids drug design  

NLE Websites -- All DOE Office Websites (Extended Search)

Neutron crystallography aids drug design Neutron crystallography aids drug design Researchers have used neutron crystallography for the first time to determine the structure of a...

20

Illicit drugs in the environment  

Science Journals Connector (OSTI)

...Nick Voulvoulis Illicit drugs in the environment Ettore Zuccato Sara Castiglioni...but risks for human health and the environment cannot be excluded. Morphine, cocaine...time. illicit drugs|drugs of abuse|environment|sewage treatment plant|wastewater...

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Account Sponsorship & Retention Policy | Argonne Leadership Computing...  

NLE Websites -- All DOE Office Websites (Extended Search)

Allocations MiraCetusVesta Tukey Policies Accounts Policy Account Sponsorship & Retention Policy ALCC Quarterly Report Policy ALCF Acknowledgment Policy Data Policy INCITE...

22

Workforce Retention Work Group | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

skilled workforce retention; health, safety and productivity; and especially preventive health care. Inform and support improvement andor development of wellness, fitness, and...

23

Radionuclide Retention in Concrete Wasteforms  

SciTech Connect

Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how wasteform performance is affected by the full range of environmental conditions within the disposal facility; the process of wasteform aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of wasteform aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the wasteforms come in contact with groundwater. Data collected throughout the course of this work will be used to quantify the efficacy of concrete wasteforms, similar to those used in the disposal of LLW and MLLW, for the immobilization of key radionuclides (i.e., uranium, technetium, and iodine). Data collected will also be used to quantify the physical and chemical properties of the concrete affecting radionuclide retention.

Wellman, Dawn M.; Jansik, Danielle P.; Golovich, Elizabeth C.; Cordova, Elsa A.

2012-09-24T23:59:59.000Z

24

Segmented vs conventional numerals: legibility and long term retention  

E-Print Network (OSTI)

the environmental chamber. Sub jects The subjects were thirty male students between the ages of 1g and 27 from the Industrial Engineering department at Texas A&M University. Subjects were divided into three groups of 10. Procedure Exposure time and number... December 1971 Ma]or Subject: Industrial Engineering SEGMENTED VS CONVENTIONAL NUMERALS: LEGIBILITY AND LONG TERM RETENTION A Thesis STEVE EDGAR HILL Approved as to style and content by: Elias Chairman of Committee) r. A. W. ortham (Head...

Hill, Steve Edgar

1971-01-01T23:59:59.000Z

25

Nanoscale retention-loss dynamics of polycrystalline PbTiO{sub 3} nanotubes.  

SciTech Connect

We observed the nanoscale retention dynamics of polycrystalline PbTiO{sub 3} nanotubes using piezoresponse force microscopy. We found that the retention loss of the nanodot domains on the nanotubes showed the stretched exponential relaxation behaviors with stretched exponential factor n being less than 1 (0.523 and 0.692), which are similar to the thin films. In addition, the nanodot domains showed a diverse relaxation time constant {tau} due to different remnant polarization of each dot domains.

Choi, H.; Kim, Y.; Hong, S.; Sung, T.-H.; Shin, H.; No, K. (Materials Science Division); (Korea Advanced Inst. of Science and Technology); (Hanyang Univ.); (Kookmin Univ.)

2011-07-01T23:59:59.000Z

26

(WPI-iCeMS) Pure Nano Drugs*  

E-Print Network (OSTI)

(WPI-iCeMS) SN-38 50 nm * Pure Nano Drugs* SN-38 10 HepG2* JST (-STEP Permeation and Retention (EPR)* EPR 20100 nm SN-38 SN-38 * SN-38 * SN-38 20 SN-38 Pure Nano Drugs

Takada, Shoji

27

Prescription Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Prescription Drugs Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue Cross and Blue Shield of New Mexico (BCBSNM) health plan includes a prescription drug benefit administered by Prime Therapeutics. The cost of the prescription drug plan is included in your medical premiums. Coverage The co-pays for prescription drugs are based on a 3-tier prescription drug benefit. Co-payments are different for formulary or non-formulary, generic, or brand/preferred name. Review the BCBSNM Drug List (pdf) to find out which tier a specific drug falls under. Co-pays Prescription drug co-pays vary from plan to plan. 2013 EPO Summary of Benefits (pdf) 2013 PPO Summary of Benefits (pdf)

28

Residential Refrigerator Recycling Ninth Year Retention Study  

E-Print Network (OSTI)

Residential Refrigerator Recycling Ninth Year Retention Study Study ID Nos. 546B, 563 Prepared RECYCLING PROGRAMS Study ID Nos. 546B and 563 Prepared for Southern California Edison Rosemead, California

29

Plan to speed up drug review approved  

Science Journals Connector (OSTI)

Plan to speed up drug review approved ... Proposed changes in the New Drug Application procedure will shorten review times, reduce paperwork, and save money ...

DAVID HANSON

1982-07-12T23:59:59.000Z

30

ADDITIVE TESTING FOR IMPROVED SULFUR RETENTION: PRELIMINARY REPORT  

SciTech Connect

The Savannah River National Laboratory is collaborating with Alfred University to evaluate the potential for additives in borosilicate glass to improve sulfur retention. This preliminary report provides further background on the incorporation of sulfur in glass and outlines the experiments that are being performed by the collaborators. A simulated waste glass composition has been selected for the experimental studies. The first phase of experimental work will evaluate the impacts of BaO, PbO, and V{sub 2}O{sub 5} at concentrations of 1.0, 2.0, and 5.0 wt % on sulfate retention in simulated high level waste borosilicate glass. The second phase of experimental work will evaluate the effects of time at the melt temperature on sulfur retention. The resulting samples will be characterized to determine the amount of sulfur remaining as well as to identify the formation of any crystalline phases. The results will be used to guide the future selection of frits and glass forming chemicals in vitrifying Department of Energy wastes containing high sulfur concentrations.

Amoroso, J.; Fox, K.

2011-09-07T23:59:59.000Z

31

Clinton plan to speed cancer drug approval  

Science Journals Connector (OSTI)

Clinton plan to speed cancer drug approval ... Accelerated approval and three other proposals "will affect at least 100 drugs now being studied," he notes, cutting FDA review time for some of these drugs from 12 months to six months. ...

1996-04-08T23:59:59.000Z

32

DOE Handbook on Recruitment and Retention Incentives | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Handbook on Recruitment and Retention Incentives Handbook on Recruitment and Retention Incentives DOE Handbook on Recruitment and Retention Incentives This desk reference contains sample recruitment, relocation, retention, and student loan incentive plans and service agreements for eligible employees; sample worksheets to assist in documenting the justification and approvals for all types of recruitment and retention incentives; information on superior qualification determinations; guidance and sample documents regarding crediting directly-related service for annual leave for new appointments; frequently asked questions regarding relocation expenses; and other relevant documents. This desk reference is intended to supplement information currently available in the following references. DOE Handbook on Recruitment and Retention Incentives

33

Auditing a database under retention policies  

Science Journals Connector (OSTI)

Auditing the changes to a database is critical for identifying malicious behavior, maintaining data quality, and improving system performance. But an accurate audit log is an historical record of the past that can also pose a serious threat to privacy. ... Keywords: Auditing, Privacy, Retention policy

Wentian Lu; Gerome Miklau; Neil Immerman

2013-04-01T23:59:59.000Z

34

Task Force on Undergraduate Retention and Graduation: Meeting Documentation  

E-Print Network (OSTI)

1 Task Force on Undergraduate Retention and Graduation: Meeting Documentation April 28, 2011 Part 1 such as tenacity impacting retention and graduation are more difficult to measure and have not been tracked

Bieber, Michael

35

Recruiting, Retention & Advancement Recruiting: Searching for Excellence and  

E-Print Network (OSTI)

#12;Recruiting, Retention & Advancement Recruiting: Searching for Excellence and Diversity: A Workshop for Faculty Search Committee Chairs Retention: Enhancing Department Climate: A Chair's Role Advancement: Senior women meetings #12;Recruiting 3-part workshops for chairs of hiring committees Based

Sheridan, Jennifer

36

300 Area Building Retention Evaluation Mitigation Plan  

SciTech Connect

Evaluate the long-term retention of several facilities associated with the PNNL Capability Replacement Laboratory and other Hanfor mission needs. WCH prepared a mitigation plan for three scenarios with different release dates for specific buildings. The evaluations present a proposed plan for providing utility services to retained facilities in support of a long-term (+20 year) lifespan in addition to temporary services to buildings with specified delayed release dates.

D. J. McBride

2007-07-03T23:59:59.000Z

37

Retention and entrainment effects: Experiments and theory for porous spheres settling in sharply stratified fluids  

E-Print Network (OSTI)

be important for accurate modeling of the vertical carbon flux in the ocean. A first step in this direction with a first-principle model based on diffusive processes. The model correctly predicts accelerations. With this parametrization, which exhibits a power law dependence on Reynolds numbers, retention times are accurately

McLaughlin, Richard M.

38

Deuterium Retention in NSTX with Lithium Conditioning  

SciTech Connect

High (approximate to 90%) deuterium retention was observed in NSTX gas balance measurements both with- and without lithiumization of the carbon plasma-facing components. The gas retained in ohmic discharges was measured by comparing the vessel pressure rise after a discharge to that of a gas-only pulse with the pumping valves closed. For neutral beam heated discharges the gas input and gas pumped by the NB cryopanels were tracked. The discharges were followed by outgassing of deuterium that reduced the retention. The relationship between retention and surface chemistry was explored with a new plasma-material interface probe connected to an in vacuo surface science station that exposed four material samples to the plasma. XPS and TDS analysis demonstrated that binding of D atoms in graphite is fundamentally changed by lithium - in particular atoms are weakly bonded in regions near lithium atoms bound to either oxygen or the carbon matrix. This is in contrast to the strong ionic bonding that occurs between D and pure Li. (C) 2010 Elsevier B.V. All rights reserved.

Skinner, C. H. [Princeton Plasma Physics Laboratory (PPPL); Allain, J. P. [Purdue University; Blanchard, W. [Princeton Plasma Physics Laboratory (PPPL); Kugel, H. W. [Princeton Plasma Physics Laboratory (PPPL); Maingi, Rajesh [ORNL; Roquemore, L. [Princeton Plasma Physics Laboratory (PPPL); Soukhanovskii, V. A. [Lawrence Livermore National Laboratory (LLNL); Taylor, C. N. [Purdue University

2011-01-01T23:59:59.000Z

39

Antiretroviral drugs  

Science Journals Connector (OSTI)

In October 2010, it will be exactly 25 years ago that the first antiretroviral drug, AZT (zidovudine, 3?-azido-2?,3?-dideoxythymidine), was described. It was the first of 25 antiretroviral drugs that in the past 25 years have been formally licensed for clinical use. These antiretroviral drugs fall into seven categories [nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), fusion inhibitors (FIs), co-receptor inhibitors (CRIs) and integrase inhibitors (INIs). The \\{INIs\\} (i.e. raltegravir) represent the most recent advance in the search for effective and selective anti-HIV agents. Combination of several anti-HIV drugs [often referred to as highly active antiretroviral therapy (HAART)] has drastically altered AIDS from an almost uniformly fatal disease to a chronic manageable one.

Erik De Clercq

2010-01-01T23:59:59.000Z

40

Cooking utensil with improved heat retention  

DOE Patents (OSTI)

A cooking utensil with improved heat retention includes an inner pot received within an outer pot and separated in a closely spaced-apart relationship to form a volume or chamber therebetween. The chamber is evacuated and sealed with foil leaves at the upper edges of the inner and outer pot. The vacuum created between the inner and outer pot, along with the minimum of thermal contact between the inner and outer pot, and the reduced radiative heat transfer due to low emissivity coatings on the inner and outer pot, provide for a highly insulated cooking utensil. Any combination of a plurality of mechanisms for selectively disabling and re-enabling the insulating properties of the pot are provided within the chamber. These mechanisms may include: a hydrogen gas producing and reabsorbing device such as a metal hydride, a plurality of metal contacts which can be adjusted to bridge the gap between the inner and outer pot, and a plurality of bimetallic switches which can selectively bridge the gap between the inner and outer pot. In addition, phase change materials with superior heat retention characteristics may be provided within the cooking utensil. Further, automatic and programmable control of the cooking utensil can be provided through a microprocessor and associated hardware for controlling the vacuum disable/enable mechanisms to automatically cook and save food.

Potter, Thomas F. (Denver, CO); Benson, David K. (Golden, CO); Burch, Steven D. (Golden, CO)

1997-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Radionuclide Retention in Concrete Wasteforms - FY13  

SciTech Connect

Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how wasteform performance is affected by the full range of environmental conditions within the disposal facility; the process of wasteform aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of wasteform aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the wasteforms come in contact with groundwater. Data collected throughout the course of this work will be used to quantify the efficacy of concrete wasteforms, similar to those used in the disposal of low-level waste and mixed low-level waste, for the immobilization of key radionuclides (i.e., uranium, technetium, and iodine). Data collected will also be used to quantify the physical and chemical properties of the concrete affecting radionuclide retention.

Snyder, Michelle MV; Golovich, Elizabeth C.; Wellman, Dawn M.; Crum, Jarrod V.; Lapierre, Robert; Dage, Denomy C.; Parker, Kent E.; Cordova, Elsa A.

2013-10-15T23:59:59.000Z

42

Volatile Species Retention During Metallic Fuel Casting  

SciTech Connect

Metallic nuclear fuels are candidate transmutation fuel forms for advanced fuel cycles. Through the operation of the Experimental Breeder Reactor II metallic nuclear fuels have been shown to be robust and easily manufactured. However, concerns have been raised concerning loss of americium during the casting process because of its high vapor pressure. In order to address these concerns a gaseous diffusion model was developed and a series of experiments using both manganese and samarium as surrogates for americium were conducted. The modeling results showed that volatility losses can be controlled to essentially no losses with a modest overpressure. Experimental results also showed volatile species retention down to no detectable losses through overpressure, although the loss values varied from the model results the same trend was seen. Bases on these results it is very probably that americium losses through volatility can be controlled to no detectable losses through application of a modest overpressure during casting.

Randall S. Fielding; Douglas L. Proter

2013-10-01T23:59:59.000Z

43

Water retention and gas relative permeability of two industrial concretes  

SciTech Connect

This experimental study aims at identifying the water retention properties of two industrial concretes to be used for long term underground nuclear waste storage structures. Together with water retention, gas transfer properties are identified at varying water saturation level, i.e. relative gas permeability is assessed directly as a function of water saturation level S{sub w}. The influence of the initial de-sorption path and of the subsequent re-saturation are analysed both in terms of water retention and gas transfer properties. Also, the influence of concrete microstructure upon water retention and relative gas permeability is assessed, using porosity measurements, analysis of the BET theory from water retention properties, and MIP. Finally, a single relative gas permeability curve is proposed for each concrete, based on Van Genuchten-Mualem's statistical model, to be used for continuous modelling approaches of concrete structures, both during drying and imbibition.

Chen Wei; Liu Jian; Brue, Flore; Skoczylas, Frederic [Univ Lille Nord de France, F-59000 Lille (France); ECLille, LML, BP 48, F-59650 Villeneuve d'Ascq (France); CNRS, UMR 8107, F-59650 Villeneuve d'Ascq (France); Davy, C.A., E-mail: catherine.davy@ec-lille.fr [Univ Lille Nord de France, F-59000 Lille (France); ECLille, LML, BP 48, F-59650 Villeneuve d'Ascq (France); CNRS, UMR 8107, F-59650 Villeneuve d'Ascq (France); Bourbon, Xavier; Talandier, Jean [Andra, 1-7 rue Jean Monnet, F-92298 Chatenay-Malabry Cedex (France)

2012-07-15T23:59:59.000Z

44

E-Print Network 3.0 - analysis retention behaviour Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

retention, which... the criterion for retention analysis) into account (Table 1). Kruskal-Wallis ANOVA revealed a significant effect... Part One SCN AND MEMORY PROCESSES...

45

Impact of approach used to determine removal levels of drugs of abuse during wastewater treatment  

Science Journals Connector (OSTI)

Abstract In this study the levels of 19 drugs of abuse were estimated throughout a wastewater treatment plant using polar organic chemical integrative samplers (POCIS), 24h composite samples and grab samples. Overall removal efficiencies and removals in between each treatment unit were calculated using load data for each sampling technique as well as removals that take into account the hydraulic residence time distribution of the treatment plant (time-shifted mass balancing approach). Amphetamine-type stimulants, cocaine and its major metabolite, benzoylecgonine and opioid levels determined with 24h composite samples were generally comparable to those obtained with POCIS and grab samples. Negative mass balances resulting from the estimation of overall removal efficiencies by POCIS, day-to-day mass balancing of 24h composite and grab sample data did not occur when the hydraulic retention time (HRT) distributions of the plant were taken into account for calculation. Among the compounds investigated, cocaine exhibited the highest overall removal (90%) while codeine had the lowest with 13%, respectively. Sampling between the treatment units revealed that highest removal occurs during biological treatment as compared to primary or secondary clarification. Methylenedioxyamphetamine (MDA), fentanyl, dihydrocodeine and heroin were not detected in wastewater at any of the sampling locations at the treatment plant regardless of the sampling technique. The study demonstrates the benefits of applying the time-shifted mass balancing approach to the calculation of removals of drugs of abuse during wastewater treatment.

Angela Rodayan; Marius Majewsky; Viviane Yargeau

2014-01-01T23:59:59.000Z

46

Mexicos ley de narcomenudeo drug policy reform and the international drug control regime  

Science Journals Connector (OSTI)

It has been over half a century since the landmark Single Convention on Narcotic Drugs was adopted, for the first time unifying international drug policy under a single treaty aimed at limiting use, manufacture, ...

Tim K Mackey; Daniel Werb; Leo Beletsky; Gudelia Rangel

2014-11-01T23:59:59.000Z

47

Formation and retention of methane in coal  

SciTech Connect

The formation and retention of methane in coalbeds was studied for ten Utah coal samples, one Colorado coal sample and eight coal samples from the Argonne Premium Coal Sample Bank.Methane gas content of the Utah and Colorado coals varied from zero to 9 cm{sup 3}/g. The Utah coals were all high volatile bituminous coals. The Colorado coal was a gassy medium volatile bituminous coal. The Argonne coals cover a range or rank from lignite to low volatile bituminous coal and were used to determine the effect of rank in laboratory studies. The methane content of six selected Utah coal seams and the Colorado coal seam was measured in situ using a special sample collection device and a bubble desorbometer. Coal samples were collected at each measurement site for laboratory analysis. The cleat and joint system was evaluated for the coal and surrounding rocks and geological conditions were noted. Permeability measurements were performed on selected samples and all samples were analyzed for proximate and ultimate analysis, petrographic analysis, {sup 13}C NMR dipolar-dephasing spectroscopy, and density analysis. The observed methane adsorption behavior was correlated with the chemical structure and physical properties of the coals.

Hucka, V.J.; Bodily, D.M.; Huang, H.

1992-05-15T23:59:59.000Z

48

September 2012, Work Force Retention Work Group Status Overview  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Work Force Retention Work Group Status Overview Work Force Retention Work Group Status Overview 2 Subgroups: Pro-Force and Non-Pro-Force Pro-Force Subgroup: Accomplishments: 1. Completion of 10 CFR 1046 [Protective Force Personnel Medical, Physical Readiness, Training, and Access Authorization Standards] as a final rule that includes modification efforts to address barriers to workforce retention. 2. Pro-Force (PF) union representative, Randy Lawson, identified this accomplishment as the single most significant step toward PF workforce retention in over 20 years. 3. Draft re-charter of PF Career Options Committee (PFCOC) to establish a PF Working Group approved by GC-63 and GC NNSA. Near Term Goals and Activities: 1. Publish 1046 as a final rule - publication anticipated this month.

49

Task Force on Undergraduate Retention and Graduation: Meeting Documentation  

E-Print Network (OSTI)

1 Task Force on Undergraduate Retention and Graduation: Meeting Documentation March 17, 2011 Part 1 Altenkirch Charge to the Committee, February 3, 2011 Meeting Date: March 17, 2011; minutes revised on April

Bieber, Michael

50

Bubble retention in synthetic sludge: Testing of alternative gas retention apparatus  

SciTech Connect

Several of the underground storage tanks currently used to store waste at Hanford have been placed on the Flammable Gas Watch List, because the waste is either known or suspected to generate, store, and episodically release flammable gases. The objective of this experimental study is to develop a method to measure gas bubble retention in simulated tank waste and in diluted simulant. The method and apparatus should (1) allow for reasonably rapid experiments, (2) minimize sample disturbance, and (3) provide realistic bubble nucleation and growth. The scope of this experimental study is to build an apparatus for measuring gas retention in simulated waste and to design the apparatus to be compatible with future testing on actual waste. The approach employed for creating bubbles in sludge involves dissolving a soluble gas into the supernatant liquid at an elevated pressure, recirculating the liquid containing the dissolved gas through the sludge, then reducing the pressure to allow bubbles to nucleate and grow. Results have been obtained for ammonia as the soluble gas and SY1-SIM-91A, a chemically representative simulated tank waste. In addition, proof-of-principle experiments were conducted with both ammonia and CO{sub 2} as soluble gases and sludge composed of 90-micron glass beads. Results are described.

Rassat, S.D.; Gauglitz, P.A.

1995-07-01T23:59:59.000Z

51

Thirtieth anniversary of the retention index according to Kovts in gas-liquid chromatography  

Science Journals Connector (OSTI)

GC retention data measured in various laboratories are given in many different forms and therefore their usefulness is limited. The retention index system according to Kovts solves the problem of the uniform expression of retention data. In this review, the main theoretical and practical results relating to retention index systems published in the past 5 years are summarized.

G. Tarjn; Sz. Nyiredy; M. Gyr; E.R. Lombosi; T.S. Lombosi; M.V. Budahegyi; S.Y. Mszros; J.M. Takcs

1989-01-01T23:59:59.000Z

52

Reactive barriers for {sup 137}Cs retention  

SciTech Connect

{sup 137}Cs was dispersed globally by cold war activities and, more recently, by the Chernobyl accident. Engineered extraction of {sup 137}Cs from soils and groundwaters is exceedingly difficult. Because the half life of {sup 137}Cs is only 30.2 years, remediation might be more effective (and less costly) if {sup 137}Cs bioavailability could be demonstrably limited for even a few decades by use of a reactive barrier. Essentially permanent isolation must be demonstrated in those few settings where high nuclear level wastes contaminated the environment with {sup 135}Cs (half life 2.3x10{sup 6} years) in addition to {sup 137}Cs. Clays are potentially a low-cost barrier to Cs movement, though their long-term effectiveness remains untested. To identify optimal clays for Cs retention Cs resorption was measured for five common clays: Wyoming Montmorillonite (SWy-1), Georgia Kaolinites (KGa-1 and KGa-2), Fithian Illite (F-Ill), and K-Metabentonite (K-Mbt). Exchange sites were pre-saturated with 0.16 M CsCl for 14 days and readily exchangeable Cs was removed by a series of LiNO{sub 3} and LiCl washes. Washed clay were then placed into dialysis bags and the Cs release to the deionized water outside the bags measured. Release rates from 75 to 139 days for SWy-1, K-Mbt and F- 111 were similar; 0.017 to 0.021% sorbed Cs released per day. Both kaolinites released Cs more rapidly (0.12 to 0.05% of the sorbed Cs per day). In a second set of experiments, clays were doped for 110 days and subjected to an extreme and prolonged rinsing process. All the clays exhibited some capacity for irreversible Cs uptake so most soils have some limited ability to act as a natural barrier to Cs migration. However, the residual loading was greatest on K-Mbt ({approximately} 0.33 wt% Cs). Thus, this clay would be the optimal material for constructing artificial reactive barriers.

KRUMHANSL,JAMES L.; BRADY,PATRICK V.; ANDERSON,HOWARD L.

2000-05-19T23:59:59.000Z

53

Portable conduit retention apparatus for releasably retaining a conduit therein  

DOE Patents (OSTI)

Portable conduit retention apparatus for releasably retaining a conduit therein. The apparatus releasably retains the conduit out of the way of nearby personnel and equipment. The apparatus includes a portable support frame defining a slot therein having an open mouth portion in communication with the slot for receiving the conduit through the open mouth portion and into the slot. A retention bar is pivotally connected to the support frame adjacent the mouth portion for releasably retaining the conduit in the slot. The retention bar freely pivots to a first position, so that the mouth portion is unblocked in order that the conduit is received through the mouth portion and into the slot. In addition, the retention bar freely pivots to a second position, so that the mouth portion is blocked in order that the conduit is retained in the slot. The conduit is released from the slot by pivoting the retention bar to the first position to unblock the mouth portion and thereafter manipulating the conduit from the slot and through the mouth portion. The apparatus may further include a mounting member attached to the support frame for mounting the apparatus on a vertical support surface. Another embodiment of the apparatus includes a shoe assembly of predetermined weight removably connected to the support frame for resting the apparatus on a floor in such a manner that the apparatus is substantially stationary on the floor.

Metzger, Richard H. (West Seneca, NY)

1998-01-01T23:59:59.000Z

54

SUBJECT: Guidance on Retention of Facility Representative Technical  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

SUBJECT: Guidance on Retention of Facility Representative Technical SUBJECT: Guidance on Retention of Facility Representative Technical Competence during Reductions in Force, 4/21/1998 SUBJECT: Guidance on Retention of Facility Representative Technical Competence during Reductions in Force, 4/21/1998 The Department's Revised Implementation Plan (IP) for Defense Nuclear Facilities Safety Board Recommendation 93-3 renews the Department's commitment to maintaining the technical capability necessary to safely manage and operate defense nuclear facilities. Retaining highly qualified employees in critical technical skills areas is vital to the maintenance of these technical capabilities. The Department has therefore committed in the revised R? to the development of a model that offices can use to proactively manage and preserve critical technical capabilities. During the

55

Japan Retools Drug Research  

Science Journals Connector (OSTI)

Japan Retools Drug Research ... Like Takedas stock price, Japans drug R&D engineflagging in recent yearsappears to be recovering. ...

JEAN-FRANOIS TREMBLAY

2013-08-05T23:59:59.000Z

56

Workforce Retention Accomplishments Presentation - Sustainability Assessment of Workforce Well-Being and Mission Readiness  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Sustainability Assessment of Workforce Sustainability Assessment of Workforce Well-Being and Mission Readiness Jodi M. Jacobson, Ph.D., University of Maryland 2 Illness and Injury Lost Work Time Generational Divide Recruitment & Retention Competition Retirement & Aging Workforce Health & Well-Being Stress Depression & Anxiety Budget Cuts Technology Talent Management Work/Life Balance Safety Accountability Security Leadership Development Workforce Sustainability Chronic Health Conditions Globalization Critical Skills Shortage Job Skill Re-Alignment Job Transitioning Healthcare Costs YOU ARE NOT ALONE! 3 Indirect Costs  "You can"t manage what you can"t measure" (Dr. Ron Goetzel, Director, Institute for Health & Productivity Studies, Cornell University)

57

Retention of neptunium in uranyl alteration phases formed during spent fuel corrosion  

SciTech Connect

Uranyl oxide hydrate phases are known to form during contact of oxide spent nuclear fuel with water under oxidizing conditions; however, less is known about the fate of fission and neutron capture products during this alteration. We describe, the first time, evidence that neptunium can become incorporated into the uranyl secondary phase, dehydrated schoepite (UO{sub 3}{lg_bullet}0.8H{sub 2}O). Based on the long-term durability of natural schoepite, the retention of neptunium in this alteration phase may be significant during spent fuel corrosion in an unsaturated geologic repository.

Buck, E.C.; Finch, R.J.; Finn, P.A.; Bates, J.K.

1997-10-01T23:59:59.000Z

58

Evolutionary Computing for Detection of Retentive Structures in Coastal Waters  

E-Print Network (OSTI)

,robillia,poty,fonlupt}@lil.univ-littoral.fr, Abstract-- The demography of anchovy fishes in the Gulf of Biscay seems to be related to the presence of so- called "retentive" hydrodynamical structures, that keep fish eggs and larvae in a favorable environment be used to decide fishing quotas or bans for the sake of preserving the natural resource. We propose two

Fernandez, Thomas

59

Arsenate and Chromate Retention Mechanisms on Goethite. 2.  

E-Print Network (OSTI)

Arsenate and Chromate Retention Mechanisms on Goethite. 2. Kinetic Evaluation Using a Pressure on goethite (R-FeOOH) were investigated using apressure-jump(p-jump)relaxationtechnique. Information provided. The adsorption/desorption of these oxyanions on goethite involved a double relaxation event. The proposed

Sparks, Donald L.

60

Oral Drug Absorption  

E-Print Network (OSTI)

properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

Yamashita, Shinji

2006-10-26T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance  

E-Print Network (OSTI)

period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

Clairambault, Jean

62

Nanotechnology Now -Press Release: "Sandia and UNM lead effort to destroy cancers: Boosting medicine with nanotechnology strengthens drug cocktail many times over" http://www.nanotech-now.com/news.cgi?story_id=42258[4/21/2011 11:23:41 AM  

E-Print Network (OSTI)

Nanotechnology Now - Press Release: "Sandia and UNM lead effort to destroy cancers: Boosting medicine with nanotechnology strengthens drug cocktail many times over" http://www.nanotech-now.com/news.cgi?story_id=42258[4/21/2011 11:23:41 AM] About Us Nanotechnology News Columns Products Directories Career Center

Brinker, C. Jeffrey

63

Selective control of SNARE recycling by Golgi retention  

Science Journals Connector (OSTI)

Abstract Two distinct sets of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) catalyze membrane fusion in the cis-Golgi and trans-Golgi. The mechanism that controls Golgi localization of \\{SNAREs\\} remains largely unknown. Here we tested three potential mechanisms, including vesicle recycling between the Golgi and the endoplasmic reticulum, partitioning in Golgi lipid microdomains, and selective intra-Golgi retention. Recycling rates showed a linear relationship with intra-Golgi mobility of SNAREs. The cis-Golgi \\{SNAREs\\} had higher mobility than intra-Golgi SNAREs, whereas vesicle \\{SNAREs\\} had higher mobility than target membrane SNAREs. The differences in SNARE mobility were not due to preferential partitioning into detergent-resistant membrane microdomains. We propose that intra-Golgi retention precludes entropy-driven redistribution of \\{SNAREs\\} to the endoplasmic reticulum and endocytic compartments.

Masayoshi Fukasawa; Anda Cornea; Oleg Varlamov

2013-01-01T23:59:59.000Z

64

Shrew response to variable woody debris retention: Implications for sustainable forest bioenergy  

Science Journals Connector (OSTI)

Abstract Shrews are integral components of forest food webs and may rely on downed woody debris to provide microhabitats that satisfy high moisture and metabolic requirements. However, woody biomass harvests glean downed woody debris to use as a bioenergy feedstock. Biomass Harvesting Guidelines (BHGs) provide guidance on the amount and distribution of downed woody debris retained after harvest to ensure ecological sustainability of woody biomass harvesting and limit detrimental effects on wildlife. However, the success of Biomass Harvesting Guidelines at reaching sustainability goals, including conservation of wildlife habitat, has not been tested in an operational setting. Thus, we compared shrew captures among six woody biomass harvesting treatments in pine plantations in North Carolina, USA from April to August 20112014 (n=4) and Georgia, USA from April to August 20112013 (n=4). Treatments included: (1) woody biomass harvest with no BHGs; (2) 15% retention with woody biomass dispersed; (3) 15% retention with woody biomass clustered; (4) 30% retention with woody biomass dispersed; (5) 30% retention with woody biomass clustered; and (6) no woody biomass harvested. We sampled shrews with drift fence arrays and compared relative abundance of shrews among treatments using analysis of variance. Additionally, we used general linear regression models to evaluate the influence of downed woody debris volume and vegetation structure on shrew capture success at each drift fence for species with >100 captures/state/year. In 53,690 trap nights, we had 1,712 shrew captures representing three species, Cryptotis parva, Blarina carolinensis, and Sorex longirostris. We did not detect consistent differences in shrew relative abundance among woody biomass harvest treatments, but relative abundance of all species increased over time as vegetation became established. In North Carolina, total shrew capture success was negatively related to volume of downed woody debris within 50m of the drift fence array (P=0.05) in 2013 and positively related to bare groundcover in 2013 (P=0.02) and 2014 (P<0.01). In Georgia, total shrew capture success was negatively related to herbaceous groundcover (P<0.01) and leaf litter groundcover (P=0.02) and positively related to woody vegetation groundcover (P<0.01) and vertical vegetation structure (P=0.03) in 2013. Our results suggest that shrews in our study area were associated more with vegetation characteristics than downed woody debris and that woody biomass harvests may have little influence on shrew abundances in the southeastern United States Coastal Plain.

S.R. Fritts; C.E. Moorman; S.M. Grodsky; D.W. Hazel; J.A. Homyack; C.B. Farrell; S.B. Castleberry

2015-01-01T23:59:59.000Z

65

Acquisition and retention performance of a rapid force production task  

E-Print Network (OSTI)

was designed to investigate (a) concurrent feedback and (b) terminal feedback under acquisition and retention conditions. It was the purpose of Experiment 2 to investigate the influences of (a) blocked presentation of practice trials and (b) random practice... performed five blocks. Subjects from both contexts were divided into concurrent, terminal, or no augmented feedback contexts. In Exper1ment 2, the subjects (N = 64) and the procedures were the same, except subjects were to learn 5 cr1terion forces (75...

Indermill, Catherine

2012-06-07T23:59:59.000Z

66

Liposomes in Drug Targeting  

Science Journals Connector (OSTI)

Transport of drugs to target tissues, cells or subcellular organelles by the use of carrier systems is now a recognized useful method of improving drug selectivity. The types of carrier that have been proposed...

G. Gregoriadis

1980-01-01T23:59:59.000Z

67

Drug Conjugates Lure Investment  

Science Journals Connector (OSTI)

Drug Conjugates Lure Investment ... Only two antibody-drug conjugates are on the market Roches Kadcyla for breast cancer and Seattle Geneticss Adcetris for lymphomabut developers are stepping up investment in this new drug class. ... The new plant is part of a larger investment by the company in biologics manufacturing (see page 17). ...

ANN THAYER

2013-10-21T23:59:59.000Z

68

Phosphorus release and retention by soils of natural isolated wetlands  

Science Journals Connector (OSTI)

Hydrological restoration of historically isolated wetlands may mitigate phosphorus (P) loss. The objectives of this study were to quantify P in soil, and to determine the effect of (1) soil characteristics on P release, and (2) antecedent soil hydrological conditions on P dynamics. Humic/fulvic acid bound P and residual P accounted for majority of P (>78%) in surface soils. Soils with highest nutrient status and labile P fractions released most P during initial flooding. Phosphorus dynamics during additional flooding were dependent on soil characteristics, antecedent soil hydrological conditions, and P levels in the water. Phosphorus retention varied between 0.3 and 8 mg m-2 d-1.

E.J. Dunne; K.R. Reddy; M.W. Clark

2006-01-01T23:59:59.000Z

69

E-Print Network 3.0 - age-dependent skeletal retention Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

Riparian Forest Soil Jodi B. Lyons... of nutrients movingfrom the upland areas to aquatic eco- systems (Lowrance, 1991). Nutrient retention varies... is considered to be generally...

70

Superior Long-Term Energy Retention and Volumetric Energy Density for Li-Rich Cathode Materials  

Science Journals Connector (OSTI)

Superior Long-Term Energy Retention and Volumetric Energy Density for Li-Rich Cathode Materials ... Department of Energy Engineering, School of

Pilgun Oh; Seungjun Myeong; Woongrae Cho; Min-Joon Lee; Minseong Ko; Hu Young Jeong; Jaephil Cho

2014-09-02T23:59:59.000Z

71

E-Print Network 3.0 - alliance rubiaceae retention Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: alliance rubiaceae retention Page: << < 1 2 3 4 5 > >> 1 Razafimandimbison & al. A basal grade...

72

A LANDSCAPE SCALE EVALUATION OF PHOSPHORUS RETENTION IN WETLANDS OF THE  

E-Print Network (OSTI)

217 A LANDSCAPE SCALE EVALUATION OF PHOSPHORUS RETENTION IN WETLANDS OF THE LAPLATTE RIVER BASIN approach to examine phosphorus retention in wetlands of the LaPlatte River basin (13,723 ha), Vermont information system. Most wetland variables had significant (p

Wang, Deane

73

RETENTION OF SULFATE IN HIGH LEVEL RADIOACTIVE WASTE GLASS  

SciTech Connect

High level radioactive wastes are being vitrified at the Savannah River Site for long term disposal. Many of the wastes contain sulfate at concentrations that can be difficult to retain in borosilicate glass. This study involves efforts to optimize the composition of a glass frit for combination with the waste to improve sulfate retention while meeting other process and product performance constraints. The fabrication and characterization of several series of simulated waste glasses are described. The experiments are detailed chronologically, to provide insight into part of the engineering studies used in developing frit compositions for an operating high level waste vitrification facility. The results lead to the recommendation of a specific frit composition and a concentration limit for sulfate in the glass for the next batch of sludge to be processed at Savannah River.

Fox, K.

2010-09-07T23:59:59.000Z

74

drug safety monitoring (DSM)  

Science Journals Connector (OSTI)

Active surveillance for drug safety (in contrast to spontaneous report system); active surveillance systems usually have higher response rates than passive systems such as the yellow card programme; ? see also

Dr. med. Dr. phil. Gerhard Nahler

2009-01-01T23:59:59.000Z

75

Career Opportunities in Biotechnology and Drug Developmentand Drug Development  

E-Print Network (OSTI)

Career Opportunities in Biotechnology and Drug Developmentand Drug Development Career Opportunities.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 1 #12-inflammatories www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development

Puglisi, Joseph

76

Anaerobic digestion of wool scouring wastewater in a digester operated semi-continuously for biomass retention  

Science Journals Connector (OSTI)

An anaerobic digester, operated semi-continuously in order to retain high concentrations of biomass in the digester, was used to treat wool scouring wastewater. At a space load of 99 kg COD m?3 day ?1 (hydraulic retention time, 28 days) >56% of the COD and >47% of the grease were removed. At these efficiencies, this rate was estimated to be at least 253 times greater than that which would be achieved in a continuously stirred digester. Preliminary studies of enzymatic pretreatment of the scouring effluent showed that significantly improved treatment rates and/or efficiencies could be achievedi.e. >70% removal of both the COD and grease at a space load of 12 kg COD m?3 day?1. It is unlikely that any substancial levels of flocculation would develop in this system and it is expected that the moderate use of polyelectrolytes would be required to help maintain the VSS concentration in the reactor.

R.G. Cail; J.P. Barford; R. Lichacz

1986-01-01T23:59:59.000Z

77

Plasma Drug Activity in Patients on Treatment for Multidrug-Resistant Tuberculosis  

Science Journals Connector (OSTI)

...research-article Clinical Therapeutics Plasma Drug Activity in Patients on Treatment...Florida, USA Little is known about plasma drug concentrations relative to quantitative...the ratio of the time to detection of plasma-cocultured Mycobacterium tuberculosis...

Stellah G. Mpagama; Norah Ndusilo; Suzanne Stroup; Happiness Kumburu; Charles A. Peloquin; Jean Gratz; Eric R. Houpt; Gibson S. Kibiki; Scott K. Heysell

2013-11-18T23:59:59.000Z

78

E-Print Network 3.0 - anticancer drug oracin Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

results for: anticancer drug oracin Page: << < 1 2 3 4 5 > >> 1 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

79

E-Print Network 3.0 - anticancer drug combretastatin-a2 Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

for: anticancer drug combretastatin-a2 Page: << < 1 2 3 4 5 > >> 1 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

80

E-Print Network 3.0 - anticancer drug development Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

for: anticancer drug development Page: << < 1 2 3 4 5 > >> 1 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

E-Print Network 3.0 - anticancer drug treatment Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

results for: anticancer drug treatment Page: << < 1 2 3 4 5 > >> 1 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

82

Increased intrapulmonary retention of radiolabeled neutrophils in early oxygen toxicity  

SciTech Connect

Sequential lung injuries, such as oxygen toxicity followed by septicemia, are common during the adult respiratory distress syndrome (ARDS). As these forms of vascular injury may be mediated in part by polymorphonuclear leukocytes (PMN), aberrant interactions between PMN and previously injured pulmonary endothelium are of both theoretical interest and clinical importance. The present study was undertaken to test the hypothesis that early oxygen toxicity at a dose that injuries pulmonary endothelium relatively selectively alters intrapulmonary neutrophil kinetics. Unanesthetized rats breathing 1.0 atmospheres oxygen for 36 h showed ultrastructural endothelial damage but no edema, injury, or neutrophilic inflammation by histologic criteria. However, in these oxygen-toxic animals, whereas initial accumulation of radiolabeled PMN in lungs was normal, washout of PMN was abnormal at 120 min after infusion, at which point the pulmonary retention of radiolabeled PMN in the lungs of oxygen-treated animals was significantly higher than in control animals (139% of control, p less than 0.0096). Features of our methodology, including avoidance of osmotic stress and use of paired control animals, appear to have greatly enhanced the sensitivity of radiolabeled neutrophils for detecting a subtle abnormality of neutrophil-endothelial interactions. Our studies in the oxygen toxicity model provide the first demonstration in vivo of abnormal intrapulmonary neutrophil kinetics in early oxygen toxicity prior to the onset of histologic evidence of lung injury or inflammation.

Rinaldo, J.E.; English, D.; Levine, J.; Stiller, R.; Henson, J.

1988-02-01T23:59:59.000Z

83

Formation and retention of methane in coal. Final report  

SciTech Connect

The formation and retention of methane in coalbeds was studied for ten Utah coal samples, one Colorado coal sample and eight coal samples from the Argonne Premium Coal Sample Bank.Methane gas content of the Utah and Colorado coals varied from zero to 9 cm{sup 3}/g. The Utah coals were all high volatile bituminous coals. The Colorado coal was a gassy medium volatile bituminous coal. The Argonne coals cover a range or rank from lignite to low volatile bituminous coal and were used to determine the effect of rank in laboratory studies. The methane content of six selected Utah coal seams and the Colorado coal seam was measured in situ using a special sample collection device and a bubble desorbometer. Coal samples were collected at each measurement site for laboratory analysis. The cleat and joint system was evaluated for the coal and surrounding rocks and geological conditions were noted. Permeability measurements were performed on selected samples and all samples were analyzed for proximate and ultimate analysis, petrographic analysis, {sup 13}C NMR dipolar-dephasing spectroscopy, and density analysis. The observed methane adsorption behavior was correlated with the chemical structure and physical properties of the coals.

Hucka, V.J.; Bodily, D.M.; Huang, H.

1992-05-15T23:59:59.000Z

84

Employee Retention and Integrated Disability Management Practices as Demand Side Factors  

Science Journals Connector (OSTI)

Introduction Demand-side employment research on company policies and practices related to retention and absence and disability management (ADM) can contribute to our understanding...Aim To examin...

Rochelle Habeck; Allan Hunt; Colleen Head Rachel

2010-12-01T23:59:59.000Z

85

Shale-Gas Permeability and Diffusivity Inferred by Improved Formulation of Relevant Retention and Transport Mechanisms  

Science Journals Connector (OSTI)

A theoretically improved model incorporating the relevant mechanisms of gas retention and transport in gas-bearing shale formations is presented for determination of intrinsic gas permeability and diffusivity. Th...

Faruk Civan; Chandra S. Rai; Carl H. Sondergeld

2011-02-01T23:59:59.000Z

86

Absorption and retention of different chemical forms of trace minerals by mature horses  

E-Print Network (OSTI)

This study was undertaken to compare the absorption and retention of copper, manganese and zinc when supplemented to the diet in the form of oxide, sulfate or organic-chelate mineral supplements. Six mature Miniature Horses were used in a...

Wagner, Elizabeth Lynn

2012-06-07T23:59:59.000Z

87

Estimation of heterosis and heterosis retention in the development of a synthetic breed of goat  

E-Print Network (OSTI)

ESTIMATION OF HETEROSIS AND HETEROSIS RETENTION IN THE DEVELOPMENT OF A SYNTHETIC BREED OF GOAT A Thesis by MATTHEW BLAIN JONES Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 1994 Major Subject Animal Breeding ESTIMATION OF HETEROSIS AND HETEROSIS RETENTION IN THE DEVELOPMENT OF A SYNTHETIC BREED OF GOAT A Thesis by MATTHEW BLAIN JONES Submitted to Texas A&M University in partial...

Jones, Matthew Blain

2012-06-07T23:59:59.000Z

88

Behavior of deuterium retention and surface morphology for VPSW/F82H  

SciTech Connect

The deuterium (D) retention for Vacuum Plasma Spray (VPS)tungsten (W)/F82H was studied using two different implantation methods, namely D plasma exposure and View the MathML source implantation. The D retention for polished VPSW/F82H after plasma exposure was found to be reduced compared to that for polycrystalline tungsten. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations indicated that porous structures around grain boundaries and the interface between VPSW layers would be potential D diffusion paths, leading to low D retention. In the case of View the MathML source implantation, the shape of D2 TDS spectrum was almost the same as that for D plasma-exposed VPSW/F82H; however, the D retention was quite high for unpolished VPSW/F82H, indicating that most of D was trapped by the oxide layer, which was produced by the VPS process. The reduction of surface area due to the polishing process also reduces D retention for VPSW/F82H. These results indicate that controlling the surface chemical states is important for the reduction of tritium retention for future fusion reactors.

Yasuhisa Oya; Masashi Shimada; Tomonori Tokunaga; Hideo Watanabe; Naoaki Yoshida; Yuji Hatano; Ryuta Kasada; Takuya Nagasaka; Akihiko Kimura; Kenji Okuno

2013-11-01T23:59:59.000Z

89

Marketing of New Drugs  

Science Journals Connector (OSTI)

Marketing of New Drugs ... But there was no doubt an excess of expenditure for promotional purposes in recent years and the industry is gradually reducing this because the sales department cannot ask for the marketing of as many new products has it did in the past. ...

PAUL DE HAEN

1964-10-12T23:59:59.000Z

90

Candidate Radiation Drugs Inch Forward  

Science Journals Connector (OSTI)

Candidate Radiation Drugs Inch Forward 10.1126/science.331.6024...radiation, workers at the damaged Fukushima nuclear plant wear protective gear...Candidate radiation drugs inch forward. | News | 0 (E)-4-carboxystyryl-4-chlorobenzylsulfone...

Yudhijit Bhattacharjee

2011-03-25T23:59:59.000Z

91

Dangerous Deception Hiding the Evidence of Adverse Drug Effects  

Science Journals Connector (OSTI)

...to address these issues, and payers spend huge sums on the drug, despite the dearth of evidence that it is better than older, cheaper agents. The health care system has a hard time performing drug-safety analyses, in large part because it relies on the pharmaceutical industry to conduct most research... On September 30, the New York Times reported that the FDA had issued a warning that the antifibrinolytic drug aprotinin could cause renal failure, congestive heart failure, stroke, and death. Dr. Jerry Avorn writes that many aspects of the aprotinin saga ...

Avorn J.

2006-11-23T23:59:59.000Z

92

Control of retention and fatigue-free characteristics in CaBi{sub 4}Ti{sub 4}O{sub 15} thin films prepared by chemical method  

SciTech Connect

Ferroelectric CaBi{sub 4}Ti{sub 4}O{sub 15} (CBTi144) thin films were deposited on Pt/Ti/SiO{sub 2}/Si substrates by the polymeric precursor method. The films present a single phase of layered-structured perovskite with polar axis orientation after annealing at 700 deg. C for 2 h in static air and oxygen atmosphere. The a/b-axis orientation of the ferroelectric film is considered to be associated with the preferred orientation of the Pt bottom electrode. It is noted that the films annealed in static air showed good polarization fatigue characteristics at least up to 10{sup 10} bipolar pulse cycles and excellent retention properties up to 10{sup 4} s. On the other hand, oxygen atmosphere seems to be crucial in the decrease of both, fatigue and retention characteristics of the capacitors. Independently of the applied electric field, the retained switchable polarization approached a nearly steady-state value after a retention time of 10 s. - Graphical abstract: Fatigue of CBTi144 thin film obtained by polymeric precursor method.

Simoes, A.Z. [Chemistry Institute, Universidade Estadual Paulista (UNESP), Rua Prof. Francisco Degni s/n, 14801-970 Araraquara-SP (Brazil)]. E-mail: alezipo@yahoo.com; Ramirez, M.A. [Chemistry Institute, Universidade Estadual Paulista (UNESP), Rua Prof. Francisco Degni s/n, 14801-970 Araraquara-SP (Brazil); Gonzalez, A.H.M. [Chemistry Institute, Universidade Estadual Paulista (UNESP), Rua Prof. Francisco Degni s/n, 14801-970 Araraquara-SP (Brazil); Riccardi, C.S. [Chemistry Institute, Universidade Estadual Paulista (UNESP), Rua Prof. Francisco Degni s/n, 14801-970 Araraquara-SP (Brazil); Ries, A. [Chemistry Institute, Universidade Estadual Paulista (UNESP), Rua Prof. Francisco Degni s/n, 14801-970 Araraquara-SP (Brazil); Longo, E. [Chemistry Institute, Universidade Estadual Paulista (UNESP), Rua Prof. Francisco Degni s/n, 14801-970 Araraquara-SP (Brazil); Varela, J.A. [Chemistry Institute, Universidade Estadual Paulista (UNESP), Rua Prof. Francisco Degni s/n, 14801-970 Araraquara-SP (Brazil)

2006-07-15T23:59:59.000Z

93

Effect of graded hypoxia on retention of technetium-99m-nitroheterocycle in perfused rat heart  

SciTech Connect

The purpose of this investigation was to determine the effects of graded hypoxia on the retention of a {sup 99m}Tc-labeled nitroimidazole. Rat hearts were perfused retrogradely with Krebs-Henseleit buffer at 37{degrees}C and paced at 5 Hz. After a 20-min stabilization period, coronary flow was maintained at 8 ml/min/g wet wt and the hearts were perfused with media equilibrated with gas mixtures containing 5% CO{sub 2} and various levels of O{sub 2}, from 544 to 29 Torr. Technetium-99m-O(PnAO-1-(2-nitroimidazole)), BMS-181321, was infused for 20 min into a side port of the aortic cannula. Perfusion continued for an additional 40 min to allow for compound clearance. Each decrease of perfusate PO{sub 2} brought about an increase in the retention of BMS-181321, resulting in a good correlation between its retention and perfusate PO{sub 2} (r=0.97). Myocardial oxygen consumption was independent of oxygen delivery when the perfusate oxygen pressure was greater than 350 Torr. Below this value, oxygen consumption declined markedly as influent PO{sub 2}. A good correlation was obtained between retention of the nitroheterocycle and the cytosolic lactate/pyruvate ratio (r=0.98). When glucose was omitted from the perfusate (PO{sub 2}=27 Torr), retention of the nitroheterocycle was increased by about 25% as compared to hearts perfused in the presence of this substrate. These results indicate that myocardial retention of BMS-181321 is coupled to the level of tissue oxygenation and that hypoxic retention may be affected by substrate input. 24 refs., 3 figs., 1 tab.

Rumsey, W.L.; Patel, B.; Linder, K.E. [Bristol-Myers Squibb Pharmaceutical Research Inst., Princeton, NJ (United States)

1995-04-01T23:59:59.000Z

94

Drug Testing for DOE Positions | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing Matrix Secretary Bodman's Memorandum Regarding Drug Testing at DOE Fact...

95

Intraosseous Venography with Carbon Dioxide in Percutaneous Vertebroplasty: Carbon Dioxide Retention in Renal Veins  

SciTech Connect

The objective of the present study was to determine the frequency of gas retention in the renal vein following carbon dioxide intraosseous venography in the prone position and, while citing references, to examine its onset mechanisms. All percutaneous vertebroplasties performed at our hospital from January to December 2005 were registered and retrospectively analyzed. Of 43 registered procedures treating 79 vertebrae, 28 procedures treating 54 vertebrae were analyzed. Vertebral intraosseous venography was performed using carbon dioxide as a contrast agent in all percutaneous vertebroplasty procedures. In preoperative and postoperative vertebral CT, gas retention in the renal vein and other areas was assessed. Preoperative CT did not show gas retention (0/28 procedures; 0%). Postoperative CT confirmed gas retention in the renal vein in 10 of the 28 procedures (35.7%). Gas retention was seen in the right renal vein in 8 procedures (28.6%), in the left renal vein in 5 procedures (17.9%), in the left and right renal veins in 3 procedures (10.7%), in vertebrae in 22 procedures (78.6%), in the soft tissue around vertebrae in 14 procedures (50.0%), in the spinal canal in 12 procedures (42.9%), and in the subcutaneous tissue in 5 procedures (17.9%). In conclusion, in our study, carbon dioxide gas injected into the vertebra frequently reached and remained in the renal vein.

Komemushi, Atsushi, E-mail: kome64@yo.rim.or.jp; Tanigawa, Noboru; Kariya, Shuji; Kojima, Hiroyuki; Shomura, Yuzo; Tokuda, Takanori; Nomura, Motoo; Terada, Jiro; Kamata, Minoru; Sawada, Satoshi [Kansai Medical University, Department of Radiology (Japan)

2008-11-15T23:59:59.000Z

96

Fission product retention in newly discovered organic-rich natural fission reactors at Oklo and Bangombe, Gabon  

SciTech Connect

The discovery of naturally occurring fission reactors in the rock strata of the Paleoproterozoic Francevillian Basin in the Republic of Gabon in equatorial West Africa led to several programs to define migration and/or retention of uranium and fissiogenic isotopes from/in the natural reactor zones. Although much understanding has been gained, new insight is needed regarding the chemical and physical parameters that control movement and retention of fission products over almost two billion years from/in the natural reactors. Seventeen known natural fission reactors sustained criticality for 0.1 to 1 million years in hydrothermally altered sedimentary rocks 1968 +/- 50 million years ago. These natural nuclear reactors attained criticality because of high concentrations of uranium in small pockets in uranium ores, the lack of neutron poisons, and because at the time they reached criticality, the abundance of [sup 235]U was five times greater than it is today. Water acted as a moderator, and temperature in the natural reactors was between 160 and 360[degrees]C. Both the uranium-rich pockets and the uranium ore bodies in which these pockets are located were formed when aqueous solutions moving through highly fractured zones in the Francevillian sedimentary rocks met organic-rich sediments. This resulted in the reduction of U(VI) in the dissolved uranyl ions to U(IV), causing the precipitation of pitchblende and uraninite. It has been proposed that between 2.2 and 1.9 billion years ago, the earth's atmosphere experienced a remarkable temporary rise in O[sub 2] content; this event may account for the uranium-bearing, oxidizing aqueous solutions in the Francevillian rocks.

Nagy, B.; Rigali, M.J. (Univ. of Arizona, Tucson (United States))

1993-01-01T23:59:59.000Z

97

E-Print Network 3.0 - aerosolized drugs encapsulated Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

University of California at San Diego Collection: Materials Science 11 Boosting medicine with nanotechnology strengthens drug cocktail many times over http:...

98

E-Print Network 3.0 - anticancer drug targets Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

University of Toronto Collection: Biology and Medicine 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

99

E-Print Network 3.0 - anticancer drug delivery Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Chemistry, University of Utah Collection: Chemistry 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

100

Multiresponse multilayer vadose zone model calibration using Markov chain Monte Carlo simulation and field water retention data  

E-Print Network (OSTI)

and field water retention data Thomas Wöhling1,2 and Jasper A. Vrugt3,4,5 Received 4 March 2010; revised 14

Vrugt, Jasper A.

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Drug Therapy: Alzheimer's Disease  

Science Journals Connector (OSTI)

...provide evidence supporting the concept that vitamin E, as well as vitamin C, has a role in delaying the onset of Alzheimer's disease. Memantine. Memantine, an N-methyl-D-aspartate antagonist recently approved by the Food and Drug Administration (FDA) for the treatment of moderate-to-severe Alzheimer's... The prevalence of Alzheimer's disease is predicted to reach 13.2 million cases in the United States. This article considers current therapeutic approaches for Alzheimer's disease. Optimal management requires accurate diagnosis, which is increasingly based on an understanding of pathophysiology. Neuroprotective strategies, cholinesterase inhibitors, psychopharmacologic agents that may reduce behavioral disturbances, and newer agents such as memantine are discussed.

Cummings J.L.

2004-07-01T23:59:59.000Z

102

Charge Retention by Gold Clusters on Surfaces Prepared Using...  

NLE Websites -- All DOE Office Websites (Extended Search)

kinetic energies. Using in-situ time of flight secondary ion mass spectrometry (TOF-SIMS) it is demonstrated that the Au11L53+ cluster retains its 3+ charge state when soft...

103

Competing retention pathways of uranium upon reaction with Fe(II)  

SciTech Connect

Biogeochemical retention processes, including adsorption, reductive precipitation, and incorporation into host minerals, are important in contaminant transport, remediation, and geologic deposition of uranium. Recent work has shown that U can become incorporated into iron (hydr)oxide minerals, with a key pathway arising from Fe(II)-induced transformation of ferrihydrite, (Fe(OH)3nH2O) to goethite (?-FeO(OH)); this is a possible U retention mechanism in soils and sediments. Several key questions, however, remain unanswered regarding U incorporation into iron (hydr)oxides and this pathways contribution to U retention, including: (i) the competitiveness of U incorporation versus reduction to U(IV) and subsequent precipitation of UO2; (ii) the oxidation state of incorporated U; (iii) the effects of uranyl aqueous speciation on U incorporation; and, (iv) the mechanism of U incorporation. Here we use a series of batch reactions conducted at pH ~7, [U(VI)] from 1 to 170 ?M, [Fe(II)] from 0 to 3 mM, and [Ca] at 0 or 4 mM) coupled with spectroscopic examination of reaction products of Fe(II)-induced ferrihydrite transformation to address these outstanding questions. Uranium retention pathways were identified and quantified using extended x-ray absorption fine structure (EXAFS) spectroscopy, x-ray powder diffraction, x-ray photoelectron spectroscopy, and transmission electron microscopy. Analysis of EXAFS spectra showed that 14 to 89% of total U was incorporated into goethite, upon reaction with Fe(II) and ferrihydrite. Uranium incorporation was a particularly dominant retention pathway at U concentrations ? 50 ?M when either uranyl-carbonato or calcium-uranyl-carbonato complexes were dominant, accounting for 64 to 89% of total U. With increasing U(VI) and Fe(II) concentrations, U(VI) reduction to U(IV) became more prevalent, but U incorporation remained a functioning retention pathway. These findings highlight the potential importance of U(V) incorporation within iron oxides as a retention process of U across a wide range of biogeochemical environments and the sensitivity of uranium retention processes to operative (bio)geochemical conditions.

Massey, Michael S.; Lezama Pacheco, Juan S.; Jones, Morris; Ilton, Eugene S.; Cerrato, Jose M.; Bargar, John R.; Fendorf, Scott

2014-10-01T23:59:59.000Z

104

Gas-Phase Identity SN2 Reactions of Halide Anions and Methyl Halides with Retention of Configuration  

E-Print Network (OSTI)

Gas-Phase Identity SN2 Reactions of Halide Anions and Methyl Halides with Retention back-side and front-side SN2 reactions are found to involve the same ion-molecule complex (X-,,,H3CX of a front-side SN2 reaction with retention of configuration at saturated carbon. Analysis of our

Schlegel, H. Bernhard

105

Body retention and tissue distribution of59Fe and 54Mn in newborn rats fed iron-supplemented cow's milk  

E-Print Network (OSTI)

Body retention and tissue distribution of59Fe and 54Mn in newborn rats fed iron-supplemented cow distribution has been studied in newborn rats. Six-day old rats, divided into three groups were artificially retention in newborn rats, whereas it enhanced 59Fe deposition in the liver and the intestinal wall and

Boyer, Edmond

106

Interventions to improve recruitment and retention in clinical trials: a survey and workshop to assess current practice and future priorities  

Science Journals Connector (OSTI)

Recruitment and retention in clinical trials is still a major challenge and are of high priority for many Clinical Trials Units. Using survey and workshop data, methods used to encourage recruitment and retention were categorised and the authors highlighted areas for prioritising further methodological research.

Peter Bower; Valerie Brueton; Carrol Gamble; Shaun Treweek; Catrin Smith; Bridget Young; Paula Williamson

2014-10-16T23:59:59.000Z

107

Larval retention and recruitment in an island population of a coral-reef fish  

Science Journals Connector (OSTI)

... windward shore (Jack's Bay) and two down-current sites on the leeward shore (Northstar and Butler Bay) during the summer and autumn of 1992. For this analysis, ... of local retention of larvae to recruitment. At both leeward reefs (Butler Bay and Northstar, Fig. 2a, b), recruitment levels were positively correlated with CF1, indicating that ...

Stephen E. Swearer; Jennifer E. Caselle; David W. Lea; Robert R. Warner

1999-12-16T23:59:59.000Z

108

Uptake and retention kinetics of para-fluorine-18-fluorobenzylguanidine in isolated rat heart  

SciTech Connect

Para-[{sup 18}F]fluorobenzylguanidine ([{sup 18}F]PFBG) is a newly developed tracer for imaging myocardial sympathetic neuronal innervation. This study investigated the uptake and retention mechanisms of [{sup 18}F]PFBG in perfused, isolated rat heart. 31 refs., 3 figs., 2 tabs.

Berry, C.R.; Garg, P.K.; Zalutsky, M.R. [North Carolina State Univ., Raleigh, NC (United States)]|[Duke Univ. Medical Center, Durham, NC (United States)] [and others

1996-12-01T23:59:59.000Z

109

On the long-term retention of geometry-centric digital engineering artifacts  

Science Journals Connector (OSTI)

This paper discusses the challenges of long-term preservation of digital geometric models and the engineering processes associated with them. For engineering, design, manufacturing, and physics-based simulation data this requires formats that are accessible ... Keywords: Digital preservation, Knowledge capture, Long-term knowledge retention, Representation, Standards

William C. Regli; Joseph B. Kopena; Michael Grauer

2011-07-01T23:59:59.000Z

110

Ca RETENTION IN YOUNG PULLETS AND LAYING HENS FED A Ca47 LABELLED DIET  

E-Print Network (OSTI)

Ca RETENTION IN YOUNG PULLETS AND LAYING HENS FED A Ca47 LABELLED DIET OF DIFFERENT Ca LEVELS K levels of dietary calcium. A basal diet poor in calcium but otherwise optimal was supplemented with CaC03 and Na2HP04 as seen below : #12;CaCO, supplement of the diet was replaced by Ca&dquo; labelled Calcium

Paris-Sud XI, Université de

111

Nuclear magnetic relaxation dispersion investigations1 of water retention mechanism by cellulose ethers in mortars2  

E-Print Network (OSTI)

Nuclear magnetic relaxation dispersion investigations1 of water retention mechanism by cellulose : 10.1016/j.cemconres.2012.06.002 #12;2 ABSTRACT22 23 We show how nuclear magnetic spin-lattice relaxation dispersion of protons-water24 (NMRD) can be used to elucidate the effect of cellulose ethers

Boyer, Edmond

112

Retention of Radioactive Substances in the Body of Rats and the Lethal Dose  

Science Journals Connector (OSTI)

... proved to be dangerous1. For this reason only two elements have been studied, namely, radon and polonium, with regard to their retention in the organism and quick elimination by ... 66 gm. to 290 gm. The present communication deals with the results obtained with radon only. A physiological solution, namely, a 10 per cent solution of glucose or ...

F. BHOUNEK; F. V. NOVK

1937-07-17T23:59:59.000Z

113

Mesh Width Influences Prey Retention in Spider Orb Webs Todd A. Blackledge & Jacquelyn M. Zevenbergen  

E-Print Network (OSTI)

Mesh Width Influences Prey Retention in Spider Orb Webs Todd A. Blackledge & Jacquelyn M. Zevenbergen Department of Biology, The University of Akron, Akron, OH, USA Introduction Orb webs depend upon threads, the sticky spirals of orb webs perform two important functions during prey cap- ture. First

Blackledge, Todd

114

Canadian study fuels move to limit rise in drug prices  

Science Journals Connector (OSTI)

... body charged with holding down the cost of patented drugs is proposing amendments to its pricing guidelines at the same time a study shows that Canadian ... guidelines at the same time a study shows that Canadian prices are often higher than the international median. The Canadian parliament recently extended patent protection ...

David Spurgeon

1993-04-29T23:59:59.000Z

115

Report on AOAC, Narcotic and Dangerous Drugs  

Science Journals Connector (OSTI)

......Report on AOAC, narcotic and dangerous drugs. | Journal Article...Report on AOAC, Narcotic and Dangerous Drugs by Anthony Romano...Bureau of Narcotics and Dangerous Drugs, Miami, Florida 33132...substances affect- ing public health." The AOAC itself maintains......

Anthony Romano; Jr.

1972-05-01T23:59:59.000Z

116

Clinical Manifestations of Allergic Diseases: Drug Hypersensitivity  

Science Journals Connector (OSTI)

Drug allergies are those adverse drug reactions that are mediated by the specific immune system. Primary sensitization may involve T-cells alone or both T and B-cells with consecutive production of drug specif...

Benno Schnyder; Werner J. Pichler

2009-01-01T23:59:59.000Z

117

266 VOLUME 13 | NUMBER 3 | MARCH 2007 NATURE MEDICINE After decades of drought, new drug possibilities floodTB pipeline  

E-Print Network (OSTI)

possibilities floodTB pipeline For the first time in decades, there are nearly 30 drugs for tuberculosis (TB--but less than just five years ago, the pipeline was running empty. The newest drug used to treat the infection and don't interact with AIDS medications. "The drug pipeline is larger than it has ever been

Cai, Long

118

A Discussion of SY-101 Crust Gas Retention and Release Mechanisms  

SciTech Connect

The flammable gas hazard in Hanford waste tanks was made an issue by the behavior of double-shell Tank (DST) 241-SY-101 (SY-101). Shortly after SY-101 was filled in 1980, the waste level began rising periodically, due to the generation and retention of gases within the slurry, and then suddenly dropping as the gases were released. An intensive study of the tank's behavior revealed that these episodic releases posed a safety hazard because the released gas was flammable, and, in some cases, the volume of gas released was sufficient to exceed the lower flammability limit (LFL) in the tank headspace (Allemann et al. 1993). A mixer pump was installed in SY-101 in late 1993 to prevent gases from building up in the settled solids layer, and the large episodic gas releases have since ceased (Allemann et al. 1994; Stewart et al. 1994; Brewster et al. 1995). However, the surface level of SY-101 has been increasing since at least 1995, and in recent months the level growth has shown significant and unexpected acceleration. Based on a number of observations and measurements, including data from the void fraction instrument (VFI), we have concluded that the level growth is caused largely by increased gas retention in the floating crust. In September 1998, the crust contained between about 21 and 43% void based on VFI measurements (Stewart et al. 1998). Accordingly, it is important to understand the dominant mechanisms of gas retention, why the gas retention is increasing, and whether the accelerating level increase will continue, diminish or even reverse. It is expected that the retained gas in the crust is flammable, with hydrogen as a major constituent. This gas inventory would pose a flammable gas hazard if it were to release suddenly. In May 1997, the mechanisms of bubble retention and release from crust material were the subject of a workshop. The evaluation of the crust and potential hazards assumed a more typical void of roughly 15% gas. It could be similar to percolati on in single-shell tank (SST) waste forms. The much higher void being currently observed in SY-101 represents essentially a new crust configuration, and the mechanisms for sudden gas release need to be evaluated. The purpose of this study is to evaluate the situation of gas bubbles in crust based on the previous work on gas bubble retention, migration, and release in simulants and actual waste. We have also conducted some visual observations of bubble migration through simulated crusts to help understand the interaction of the various mechanisms.

SD Rassat; PA Gauglitz; SM Caley; LA Mahoney; DP Mendoza

1999-02-23T23:59:59.000Z

119

THUMBS DOWN ON DRUG WAR WEAPON  

Science Journals Connector (OSTI)

THUMBS DOWN ON DRUG WAR WEAPON ... Mycoherbicides have been viewed as a potentially potent weapon in the worldwide war on illicit drugs. ...

CHERYL HOGUE

2011-12-05T23:59:59.000Z

120

November 13 - 15, 2012 HSS Work Group Leadership Meeting Summary - Work Force Retention  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Work Force Retention Work Group Work Force Retention Work Group Co-Lead Telecom November 16, 2012 DRAFT Discussion Overview Purpose: This HSS Focus Group Work Group telecom was held with the Work Group Co-Leads to discuss change elements and strategic direction to support accelerated efforts to advancing progress, productivity and performance within each of the Work Groups. Although current roles within all of the Work Groups and Focus Group efforts remain the same, the addition of centralized leadership and oversight by representatives (2) of the Departmental Representative to the Defense Nuclear Facilities Safety Board are established. 1. Leadership Transition * Co-Leads will continue to provide technical functions * Functions of the Focus Group Program will remain the same. [Lily/Stephanie]

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

RESRAD soil concentration guidelines for the Old F-Area Retention Basin  

SciTech Connect

Concentration guidelines for residual radionuclides in soil at the site of the Old F-Area Retention Basin have been calculated using a dose-based approach. Estimation of these soil guidelines was completed using RESRAD 5.0 in accordance with the DOE RESRAD methodology specified in DOE/CH/8901. Guidelines are provided for the two predominant nuclides, Sr-90 and Cs-137, known to be present in the soil beneath the old basin. A guideline is also given for Pu-238 since it is known to exist at the H-Area Retention Basin. Site-specific soil characteristics are defined for the areas above, within, and beneath the contaminated zone.

Hamby, D.M.

1994-02-24T23:59:59.000Z

122

Arsenate and Arsenite Retention and Release in Oxide and Sulfide Dominated Systems  

E-Print Network (OSTI)

Arsenate and Arsenite Retention and Release in Oxide and Sulfide Dominated Systems Principal Investigator: Richard H. Loeppert Co-Investigators: Amita Jain Klaus Raven Jianlin Wang Soil & Crop Sciences Dept. Texas A&M University College Station, TX... Resources Institute. Non-Federal matching funds were provided by the Soil & Crop Sciences Dept., Texas A&M University, College Station, TX. A portion of this report was adapted from a part of a dissertation by Jianlin Wang which will be submitted...

Loeppert, Richard H.; Jain, Amita; Raven, Klaus; Wang, Jianlin

123

Determination of the retention function of [superscript 67]Ga in canine  

E-Print Network (OSTI)

()))()] Fecal excretion was the primary route of elimination of gallium, accounting for 63K of the gallium excreted, during the 12 days of observation, Due to the wide variation in gallium retention exhibited by the individual dogs, it is recommended... ABSTRACT . . . ~ ACKNOWLEDGEMENTS TABLE OF CONTENTS LIST OF TABLES LIST OF FIGURES INTRODUCTION LITERATURE REVIEW vi vii viii 3 History Gallium Kinetics Physical Properties of 67Ga METHODS AND MATERIAL 3 4 18 21 Research Subjects...

Schoenbucher, Bruce

2012-06-07T23:59:59.000Z

124

Heterosis and Heterosis Retention for Reproductive and Maternal Traits in Nellore-Angus Crossbred Cows  

E-Print Network (OSTI)

HETEROSIS AND HETEROSIS RETENTION FOR REPRODUCTIVE AND MATERNAL TRAITS IN NELLORE-ANGUS CROSSBRED COWS A Dissertation by MOHAMMAD DIYA TALAL HAMED OBEIDAT Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements hqt the degree of DOCTOR OF PHILOSOPHY Chair of Committee, David G. Riley Committee Members, James O. Sanders Andy D. Herring Jason E. Sawyer Head of Department, H. Russell Cross August 2013 Major...

Obeidat, Mohammad Diya Talal Hamed

2013-07-08T23:59:59.000Z

125

A Study of Prevention and Retention Strategies for Successful Urban Secondary High School Hispanic Students  

E-Print Network (OSTI)

A STUDY OF PREVENTION AND RETENTION STRATEGIES FOR SUCCESSFUL URBAN SECONDARY HIGH SCHOOL HISPANIC STUDENTS A Dissertation by ROBERTO IBARRA LOPEZ Submitted to the Office of Graduate Studies of Texas A&M University... in partial fulfillment of the requirements for the degree of DOCTOR OF EDUCATION Approved by: Chair of Committee, Mario S. Torres Committee Members, Virginia Collier Larry Dooley Ben Welch Head of Department, Fredrick M. Nafukho May 2013...

Lopez, Roberto I

2013-01-14T23:59:59.000Z

126

Professional School Psychology Programs' Recruitment and Retention of Culturally and Linguistically Diverse Students  

E-Print Network (OSTI)

graduate students of color. American Psychologist, 61, 143-156. Sanders, J. B., Wilson, M., & Jones, J. (2010). Generating Markets: Recruitment for programs and program faculty, encouraging diversity. Trainers Forum, 29 (2),32-35. Solomon, David J... PROFESSIONAL PSYCHOLOGY PROGRAMS? RECRUITMENT AND RETENTION OF CULTURALLY AND LINGUISTICALLY DIVERSE STUDENTS Major: Mathematics April 2011 Submitted to the Office of Undergraduate Research Texas A&M University...

Smith, Leann

2011-08-08T23:59:59.000Z

127

Theoretical Analysis of Antibody Targeting of Tumor Spheroids: Importance of Dosage for Penetration, and Affinity for Retention  

Science Journals Connector (OSTI)

...processes determine tumor penetration rate and subsequent retention...incrementally affect the rate of tumor penetration. The moving reaction front...different parameters affect the rate of tumor penetration. R, Ag t , and describe...

Christilyn P. Graff and K. Dane Wittrup

2003-03-15T23:59:59.000Z

128

Investigation of the use of nanofluids to enhance the In-Vessel Retention capabilities of Advanced Light Water Reactors  

E-Print Network (OSTI)

Nanofluids at very low concentrations experimentally exhibit a substantial increase in Critical Heat Flux (CHF) compared to water. The use of a nanofluid in the In-Vessel Retention (IVR) severe accident management strategy, ...

Hannink, Ryan Christopher

2007-01-01T23:59:59.000Z

129

Investigation of downward facing critical heat flux with water-based nanofluids for In-Vessel Retention applications  

E-Print Network (OSTI)

In-Vessel Retention ("IVR") is a severe accident management strategy that is power limiting to the Westinghouse AP1000 due to critical heat flux ("CHF") at the outer surface of the reactor vessel. Increasing the CHF level ...

DeWitt, Gregory L

2011-01-01T23:59:59.000Z

130

The effect of stone retention walls on soil productivity and crop performance on selected hillside farms in southern Honduras  

E-Print Network (OSTI)

THE EFFECT OF STONE RETENTION WALLS ON SOIL PRODUCTIVITY AND CROP PERFORMANCE ON SELECTED HILLSIDE FARMS IN SOUTHERN HONDURAS A Thesis by MARC ELLERY THOMPSON Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1992 Major Subject Soil Science THE EFFECT OF STONE RETENTION WALLS ON SOIL PRODUCTIVITY AND CROP PERFORMANCE ON SELECTED HILLSIDE FARMS IN SOUTHERN HONDURAS A Thesis by MARC...

Thompson, Marc Ellery

1992-01-01T23:59:59.000Z

131

The overdose of drugs in Japan  

Science Journals Connector (OSTI)

... spenders on prescription drugs. Among the top-selling drugs are anti-cancer agents peculiar to Japan that are of questionable efficacy and yet have sales of hundreds of millions of dollars ... -cancer drugs in other developed nations. Moreover, several of the drugs sold only in Japan have serious side effects. Justification of these contentions is to be found in Tables ...

Masanori Fukushima

1989-12-28T23:59:59.000Z

132

Fission product retention in TRISCO coated UO sub 2 particle fuels subjected to HTR simulated core heating tests  

SciTech Connect

Results of the examination and analysis of 25,730 individual microspheres from spherical fuel elements HFR-K3/1 and HFR-K3/3 are reported. The parent spheres were irradiated in excess of end-of-life exposure and subsequently subjected to simulated core heating tests in a special high-temperature furnace at Forschungszentrum, Juelich, GmbH (KFA). Following the heating tests, the spheres were electrolytically deconsolidated to obtain unbonded fuel particles for Irradiated Microsphere Gamma Analyzer (IMGA) analysis. For sphere HFR-K3/1, which was heated for 500 h at 1600{degree}C, only four particles were identified as having released fission products. The remaining particles from the sphere showed no statistical evidence of fission product release. Scanning Electron Microscopy (SEM) examination showed that three of the defect particles had large sections of the TRISO coating missing, while the fourth appeared normal. For sphere HFR-K3/3, which was heated for 100 h at 1800{degree}C, the IMGA data revealed that fission product release (cesium) from individual particles was significant and that there was large particle-to-particle variation in retention capabilities. Individual particle release (cesium) averaged ten times the KFA-measured integral spherical fuel element release value. In addition, the bimodal distribution of the individual particle data indicated that two distinct modes of failure at fuel temperatures of 1800{degree}C and above may exist. 6 refs., 6 figs., 4 tabs.

Baldwin, C.A.; Kania, M.J.

1990-11-01T23:59:59.000Z

133

Optimal periodic control of a drug delivery system Subbarao Varigonda 1  

E-Print Network (OSTI)

drug infusion strategies for maximizing a time averaged measure of drug effect are investigated infusion provides a locally improved average effect compared to steady infusion are characterized using 1­2 hr), as steady infusion leads to nearly complete sup- pression of gonadal function [24

Georgiou, Tryphon T.

134

Comparison of mean retention time (MRT) of markers in the reticulorumen (RR) estimated by modelling their faecal  

E-Print Network (OSTI)

-EDTA) were injected via the rumen cannula through the reticulo-omasal orifice prior to duodenal sampling (9 by modelling and algebraic methods were close. Markers (digesta phases) had an effect on accuracy of MRTRR

Paris-Sud XI, Université de

135

SUMMARY OF FY11 SULFATE RETENTION STUDIES FOR DEFENSE WASTE PROCESSING FACILITY GLASS  

SciTech Connect

This report describes the results of studies related to the incorporation of sulfate in high level waste (HLW) borosilicate glass produced at the Savannah River Site (SRS) Defense Waste Processing Facility (DWPF). A group of simulated HLW glasses produced for earlier sulfate retention studies was selected for full chemical composition measurements to determine whether there is any clear link between composition and sulfate retention over the compositional region evaluated. In addition, the viscosity of several glasses was measured to support future efforts in modeling sulfate solubility as a function of predicted viscosity. The intent of these studies was to develop a better understanding of sulfate retention in borosilicate HLW glass to allow for higher loadings of sulfate containing waste. Based on the results of these and other studies, the ability to improve sulfate solubility in DWPF borosilicate glasses lies in reducing the connectivity of the glass network structure. This can be achieved, as an example, by increasing the concentration of alkali species in the glass. However, this must be balanced with other effects of reduced network connectivity, such as reduced viscosity, potentially lower chemical durability, and in the case of higher sodium and aluminum concentrations, the propensity for nepheline crystallization. Future DWPF processing is likely to target higher waste loadings and higher sludge sodium concentrations, meaning that alkali concentrations in the glass will already be relatively high. It is therefore unlikely that there will be the ability to target significantly higher total alkali concentrations in the glass solely to support increased sulfate solubility without the increased alkali concentration causing failure of other Product Composition Control System (PCCS) constraints, such as low viscosity and durability. No individual components were found to provide a significant improvement in sulfate retention (i.e., an increase of the magnitude necessary to have a dramatic impact on blending, washing, or waste loading strategies for DWPF) for the glasses studied here. In general, the concentrations of those species that significantly improve sulfate solubility in a borosilicate glass must be added in relatively large concentrations (e.g., 13 to 38 wt % or more of the frit) in order to have a substantial impact. For DWPF, these concentrations would constitute too large of a portion of the frit to be practical. Therefore, it is unlikely that specific additives may be introduced into the DWPF glass via the frit to significantly improve sulfate solubility. The results presented here continue to show that sulfate solubility or retention is a function of individual glass compositions, rather than a property of a broad glass composition region. It would therefore be inappropriate to set a single sulfate concentration limit for a range of DWPF glass compositions. Sulfate concentration limits should continue to be identified and implemented for each sludge batch. The current PCCS limit is 0.4 wt % SO{sub 4}{sup 2-} in glass, although frit development efforts have led to an increased limit of 0.6 wt % for recent sludge batches. Slightly higher limits (perhaps 0.7-0.8 wt %) may be possible for future sludge batches. An opportunity for allowing a higher sulfate concentration limit at DWPF may lay lie in improving the laboratory experiments used to set this limit. That is, there are several differences between the crucible-scale testing currently used to define a limit for DWPF operation and the actual conditions within the DWPF melter. In particular, no allowance is currently made for sulfur partitioning (volatility versus retention) during melter processing as the sulfate limit is set for a specific sludge batch. A better understanding of the partitioning of sulfur in a bubbled melter operating with a cold cap as well as the impacts of sulfur on the off-gas system may allow a higher sulfate concentration limit to be established for the melter feed. This approach would have to be taken carefully to ensure that a

Fox, K.; Edwards, T.

2012-05-08T23:59:59.000Z

136

Soil Water Retention and Relative Permeability for Full Range of Saturation  

SciTech Connect

Common conceptual models for unsaturated flow often rely on the oversimplified representation of medium pores as a bundle of cylindrical capillaries and assume that the matric potential is attributed to capillary forces only. The adsorptive surface forces are ignored. It is often assumed that aqueous flow is negligible when a soil is near or at the residual water content. These models are successful at high and medium water contents but often give poor results at low water contents. These models do not apply to conditions at which water content is less than the residual water content. We extend the lower bound of existing water-retention functions and conductivity models from residual water content to the oven-dry condition (i.e., zero water content) by defining a state-dependent, residual-water content for a soil drier than a critical value. Furthermore, a hydraulic conductivity model for smooth uniform spheres was modified by introducing a correction factor to describe the film flow-induced hydraulic conductivity for natural porous media. The total unsaturated hydraulic conductivity is the sum of those due to capillary and film flow. The extended retention and conductivity models were verified with six datasets from the literature. Results show that, when the soil is at high and intermediate water content, there is no difference between the un-extended and the extended models; when the soil is at low water content, the un-extended models overestimate the water content but under-estimate the conductivity while the extended models match the retention and conductivity measurements well.

Zhang, Z. F.

2010-09-28T23:59:59.000Z

137

Hanford Facility dangerous waste permit application, liquid effluent retention facility and 200 area effluent treatment facility  

SciTech Connect

The Hanford Facility Dangerous Waste Permit Application is considered to 10 be a single application organized into a General Information Portion (document 11 number DOE/RL-91-28) and a Unit-Specific Portion. The scope of the 12 Unit-Specific Portion is limited to Part B permit application documentation 13 submitted for individual, `operating` treatment, storage, and/or disposal 14 units, such as the Liquid Effluent Retention Facility and 200 Area Effluent 15 Treatment Facility (this document, DOE/RL-97-03). 16 17 Both the General Information and Unit-Specific portions of the Hanford 18 Facility Dangerous Waste Permit Application address the content of the Part B 19 permit application guidance prepared by the Washington State Department of 20 Ecology (Ecology 1987 and 1996) and the U.S. Environmental Protection Agency 21 (40 Code of Federal Regulations 270), with additional information needs 22 defined by the Hazardous and Solid Waste Amendments and revisions of 23 Washington Administrative Code 173-303. For ease of reference, the Washington 24 State Department of Ecology alpha-numeric section identifiers from the permit 25 application guidance documentation (Ecology 1996) follow, in brackets, the 26 chapter headings and subheadings. A checklist indicating where information is 27 contained in the Liquid Effluent Retention Facility and 200 Area Effluent 28 Treatment Facility permit application documentation, in relation to the 29 Washington State Department of Ecology guidance, is located in the Contents 30 Section. 31 32 Documentation contained in the General Information Portion is broader in 33 nature and could be used by multiple treatment, storage, and/or disposal units 34 (e.g., the glossary provided in the General Information Portion). Wherever 35 appropriate, the Liquid Effluent Retention Facility and 200 Area Effluent 36 Treatment Facility permit application documentation makes cross-reference to 37 the General Information Portion, rather than duplicating text. 38 39 Information provided in this Liquid Effluent Retention Facility and 40 200 Area Effluent Treatment Facility permit application documentation is 41 current as of June 1, 1997.

Coenenberg, J.G.

1997-08-15T23:59:59.000Z

138

Axial thermal medium delivery tubes and retention plates for a gas turbine rotor  

DOE Patents (OSTI)

In a multi-stage turbine rotor, tubes are disposed in openings adjacent the rotor rim for flowing a thermal medium to rotor buckets and returning spent thermal medium. The tubes have axially spaced lands of predetermined wall thickness with thin-walled tube sections between the lands and of increasing thickness from the forward to the aft ends of the tubes. A pair of retention plates are carried on the aft end face of the aft wheel and straddle the tube and engage against a shoulder on the tube to preclude displacement of the tube in an aft direction.

Mashey, Thomas Charles (Coxsackie, NY)

2002-01-01T23:59:59.000Z

139

Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance  

E-Print Network (OSTI)

as: Wu: Drug metabolizing enzyme activities versus geneticRoles for Old Molecules: Enzymes in Personalized Medicine,Access Drug metabolizing enzyme activities versus genetic

Wu, Alan HB

2011-01-01T23:59:59.000Z

140

Flow cytometry aids basic cell biology research and drug discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Life Technologies Corporation and LANL have released the Attune® Acoustic Focusing Cytometer, featuring a reduced footprint, reduced consumables, and an affordable price. April 3, 2012 Attune® Acoustic Focusing Cytometer The Attune® Acoustic Focusing Cytometer achieves sample throughput at rates over 10 times faster than other cytometers-up to 1,000 μL per minute. In December 2009, Life Technologies Corporation announced the release of the Attune® Acoustic Focusing Cytometer, a first-of-its-kind cytometer system based on technology developed at Los Alamos National Laboratory (LANL). Examining cells has never been clearer with LANL's use of acoustic waves

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Identifying Drug (Cocaine) Intake Events from Acute Physiological Response in the Presence of  

E-Print Network (OSTI)

of healthcare (called mobile health or mHealth), where consumers can monitor, manage, and improve health worthy of real-time intervention for a drug user wanting to quit. The first step in building such mHealth

Kumar, Santosh

142

Radionuclide Retention Mechanisms in Secondary Waste-Form Testing: Phase II  

SciTech Connect

This report describes the results from laboratory tests performed at Pacific Northwest National Laboratory (PNNL) for Washington River Protection Solutions (WRPS) to evaluate candidate stabilization technologies that have the potential to successfully treat liquid secondary waste stream effluents produced by the Hanford Tank Waste Treatment and Immobilization Plant (WTP). WRPS is considering the design and construction of a Solidification Treatment Unit (STU) for the Effluent Treatment Facility (ETF) at Hanford. The ETF, a multi-waste, treatment-and-storage unit that has been permitted under the Resource Conservation and Recovery Act (RCRA), can accept dangerous, low-level, and mixed wastewaters for treatment. The STU needs to be operational by 2018 to receive secondary liquid waste generated during operation of the WTP. The STU will provide the additional capacity needed for ETF to process the increased volume of secondary waste expected to be produced by WTP. This report on radionuclide retention mechanisms describes the testing and characterization results that improve understanding of radionuclide retention mechanisms, especially for pertechnetate, {sup 99}TcO{sub 4}{sup -} in four different waste forms: Cast Stone, DuraLith alkali aluminosilicate geopolymer, encapsulated fluidized bed steam reforming (FBSR) product, and Ceramicrete phosphate bonded ceramic. These data and results will be used to fill existing data gaps on the candidate technologies to support a decision-making process that will identify a subset of the candidate waste forms that are most promising and should undergo further performance testing.

Um, Wooyong; Valenta, Michelle M.; Chung, Chul-Woo; Yang, Jungseok; Engelhard, Mark H.; Serne, R. Jeffrey; Parker, Kent E.; Wang, Guohui; Cantrell, Kirk J.; Westsik, Joseph H.

2011-09-26T23:59:59.000Z

143

RETENTION AND CHEMICAL SPECIATION OF URANIUM IN A WETLAND ON THE SAVANNAH RIVER SITE  

SciTech Connect

Uranium speciation and retention mechanism onto Savannah River Site (SRS) wetland sediments was studied using batch (ad)sorption experiments, sequential extraction desorption tests and U L{sub 3}-edge X-ray absorption near-edge structure (XANES) spectroscopy of contaminated wetland sediments. U was highly retained by the SRS wetland sediments. In contrast to other similar but much lower natural organic matter (NOM) sediments, significant sorption of U onto the SRS sediments was observed at pH <4 and pH >8. Sequential extraction tests indicated that the U(VI) species were primarily associated with the acid soluble fraction (weak acetic acid extractable) and NOM fraction (Na-pyrophosphate extractable). Uranium L3- edge XANES spectra of the U-retained sediments were nearly identical to that of uranyl acetate. The primary oxidation state of U in these sediments was as U(VI), and there was little evidence that the high sorptive capacity of the sediments could be ascribed to abiotic or biotic reduction to the less soluble U(IV) species. The molecular mechanism responsible for the high U retention in the SRS wetland sediments is likely related to the chemical bonding of U to organic carbon.

Li, D.; CHANG, H.: SEAMAN, J.; Jaffe, P.; Groos, P.; Jiang, D.; Chen, N.; Lin, J.; Arthur, Z.; Scheckel, K.; Kaplan, D.

2013-06-17T23:59:59.000Z

144

Adulteration of Drugs-of-Abuse Specimens  

Science Journals Connector (OSTI)

Persons abusing drugs attempt to adulterate urine specimens in ... fluid and various detoxifying agents available through the Internet is a common practice. Household chemicals such ... mask drug testing if the c...

Amitava Dasgupta

2005-01-01T23:59:59.000Z

145

Vetting Threats To Safe Drug Supplies  

Science Journals Connector (OSTI)

Vetting Threats To Safe Drug Supplies ... Representatives from government, drug companies, and national and international law enforcement agencies struggled to characterize what all agree is a large, growing, and frustratingly nebulous threat to public health and safety. ...

RICK MULLIN

2012-04-01T23:59:59.000Z

146

Prostate drug Proscar cleared for marketing  

Science Journals Connector (OSTI)

Prostate drug Proscar cleared for marketing ... The Food & Drug Administration has approved marketing of a pill developed by Merck & Co., Rahway, N.J., as an alternative to surgery for treating enlargement of the prostate gland. ...

STEPHEN STINSON

1992-06-29T23:59:59.000Z

147

Protein-Based Nanomedicine Platforms for Drug Delivery. | EMSL  

NLE Websites -- All DOE Office Websites (Extended Search)

Protein-Based Nanomedicine Platforms for Drug Delivery. Protein-Based Nanomedicine Platforms for Drug Delivery. Abstract: Drug delivery systems have been developed for many years,...

148

The pipeline and future of drug development in schizophrenia  

E-Print Network (OSTI)

The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

Gray, J A; Roth, B L

2007-01-01T23:59:59.000Z

149

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...  

NLE Websites -- All DOE Office Websites (Extended Search)

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

150

Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast  

SciTech Connect

Nuclear retention of pre-mRNAs is tightly regulated by several security mechanisms that prevent pre-mRNA export into the cytoplasm. Recently, spliceostatin A, a methylated derivative of a potent antitumor microbial metabolite FR901464, was found to cause pre-mRNA accumulation and translation in mammalian cells. Here we report that spliceostatin A also inhibits splicing and nuclear retention of pre-mRNA in a fission yeast strain that lacks the multidrug resistance protein Pmd1. As observed in mammalian cells, spliceostatin A is bound to components of the SF3b complex in the spliceosome. Furthermore, overexpression of nup211, a homolog of Saccharomyces cerevisiae MLP1, suppresses translation of pre-mRNAs accumulated by spliceostatin A. These results suggest that the SF3b complex has a conserved role in pre-mRNA retention, which is independent of the Mlp1 function.

Lo, Chor-Wai [Chemical Genetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Department of Biotechnology, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657 (Japan); Kaida, Daisuke; Nishimura, Shinichi; Matsuyama, Akihisa; Yashiroda, Yoko; Taoka, Hiroshi [Chemical Genetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Ishigami, Ken; Watanabe, Hidenori [Department of Applied Biological Chemistry, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657 (Japan); Nakajima, Hidenori [Drug Discovery Research, Fermentation Research Laboratories, Astellas Pharma Inc., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698 (Japan); Tani, Tokio [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555 (Japan); Horinouchi, Sueharu [Department of Biotechnology, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657 (Japan); Yoshida, Minoru [Chemical Genetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Japan Science and Technology Corporation (JST), CREST Research Project, Kawaguchi, Saitama 332-0012 (Japan)], E-mail: yoshidam@riken.jp

2007-12-21T23:59:59.000Z

151

The Effect of Blocked Versus Random Task Practice Schedules on the Acquisition and Retention of Surgical Skills  

Science Journals Connector (OSTI)

Background When learning multiple tasks, blocked or random training schedules may be used. We assessed the effects of blocked and random schedules on the acquisition and retention of laparoscopic skills. Methods 36 laparoscopy novices were randomized to practice laparoscopic tasks using blocked, random, or no additional training. Participants performed immediate post-tests, followed by retention tests six weeks later. Outcomes included previously validated Fundamentals of Laparoscopic Surgery (FLS) and hand-motion efficiency (HME) scores. Results Both blocked and random groups had significantly higher FLS and HME scores over baseline on post-tests for each task (p<0.05) and higher overall FLS scores than controls on retention tests (p<0.01). No difference was seen between the blocked and random groups in the amount of skill acquired or skill retained. Conclusion Both blocked and random training schedules can be considered as valid training options to allow programs and learners to tailor training to their individual needs.

Justin D. Rivard; Ashley S. Vergis; Bertram J. Unger; Lawrence M. Gillman; Krista M. Hardy; Jason Park

2014-01-01T23:59:59.000Z

152

Drugs: A tangled web of targets  

Science Journals Connector (OSTI)

... was a good year. The US Food and Drug Administration (FDA) had just approved memantine, the first in a class of drugs that reduces abnormal brain activity. Scientists had ... based on each, and the field seemed to be moving in the right direction. Memantine is one of several drugs on the market in Europe and the United States that ...

Lauren Gravitz

2011-07-13T23:59:59.000Z

153

Iontophoretic drug delivery system: A review  

Science Journals Connector (OSTI)

Among the recent developments in the field of transdermal drug delivery, iontophoresis has emerged as a very promising tool for this purpose. Various studies have been performed on drug delivery through the skin using electric current. Iontophoresis ... Keywords: Iontophoresis, iontophoretic systems, transdermal drug delivery

Ajay Semalty; Mona Semalty; Ranjit Singh; Shailendra K. Saraf; Shubhini Saraf

2007-09-01T23:59:59.000Z

154

Mechanisms of gas retention and release: Experimental results for Hanford waste tanks 241-AW-101 and 241-AN-103  

SciTech Connect

The 177 storage tanks at Hanford contain a vast array of radioactive waste forms resulting, primarily, from nuclear materials processing. Through radiolytic, thermal, and other decomposition reactions of waste components, gaseous species including hydrogen, ammonia, and the oxidizer nitrous oxide are generated within the waste tanks. Many of these tanks are known to retain and periodically release quantities of these flammable gas mixtures. The primary focus of the Flammable Gas Project is the safe storage of Hanford tank wastes. To this end, we strive to develop an understanding of the mechanisms of flammable gas retention and release in Hanford tanks through laboratory investigations on actual tank wastes. These results support the closure of the Flammable Gas Unreviewed Safety Question (USQ) on the safe storage of waste tanks known to retain flammable gases and support resolution of the broader Flammable Gas Safety Issue. The overall purpose of this ongoing study is to develop a comprehensive and thorough understanding of the mechanisms of flammable gas retention and release. The first objective of the current study was to classify bubble retention and release mechanisms in two previously untested waste materials from Tanks 241-AN-103 (AN-103) and 241-AW-101 (AW-101). Results were obtained for retention mechanisms, release characteristics, and the maximum gas retention. In addition, unique behavior was also documented and compared with previously studied waste samples. The second objective was to lengthen the duration of the experiments to evaluate the role of slowing bubble growth on the retention and release behavior. Results were obtained for experiments lasting from a few hours to a few days.

Rassat, S.D.; Gauglitz, P.A.; Bredt, P.R.; Mahoney, L.A.; Forbes, S.V.; Tingey, S.M.

1997-09-01T23:59:59.000Z

155

Time dependences of atmospheric Carbon dioxide fluxes  

E-Print Network (OSTI)

Understanding the lifetime of CO2 in the atmosphere is critical for predictions regarding future climate changes. A simple mass conservation analysis presented here generates tight estimations for the atmosphere's retention time constant. The analysis uses a leaky integrator model that combines the observed deficit (only less than 40% of CO2 produced from combustion of fossil fuels is actually retained in the atmosphere, while more than 60% is continuously shed) with the exponential growth of fossil fuel burning. It reveals a maximum characteristic time of less than 23 year for the transfer of atmospheric CO2 to a segregation sink. This time constant is further constrained by the rapid disappearance of 14C after the ban of atmospheric atomic bomb tests, which provides a lower limit of 18 years for this transfer. The study also generates evaluations of other CO2 fluxes, exchange time constants and volumes exchanged. Analysis of large harmonic oscillations of atmospheric CO2 concentration, often neglected in th...

DeSalvo, Riccardo

2014-01-01T23:59:59.000Z

156

May 21, 2012, Office of Health, Safety and Security (HSS) Focus Group Work Force Retention Work Group Charter  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Work Force Retention Work Group Charter Work Force Retention Work Group Charter In an ongoing effort to further the improvement of health, safety, environmental, and security performance within the Department, DOE is engaged in the establishment of work groups to pursue health and safety improvements across the DOE Complex. These efforts support DOE's responsibility as owner/manager to protect its greatest asset: the worker. The work groups support DOE's integrated safety management system and further DOE's best interests by fostering worker involvement and partnerships to maximize continuity of operations and the success of the Department's national security mission.

157

Power Law Size-Distributed Heterogeneity Explains Colloid Retention on Soda Lime Glass in the Presence of Energy Barriers  

Science Journals Connector (OSTI)

Power Law Size-Distributed Heterogeneity Explains Colloid Retention on Soda Lime Glass in the Presence of Energy Barriers ... This is shown in Figure 1 under the condition of 80 nm heterodomains and 6 mM IS, where the ZOIs and the corresponding colloidcollector interaction force profiles as a function of minimum separation distance (H) are shown for the three colloid sizes examined in this study (blue = 0.25 ?m, green = 1.1 ?m, red = 1.95 ?m). ... Such work will determine whether representing retention via discrete heterogeneity yields a distinct but logical set of heterodomain representations among mineral surfaces predominant in groundwater aquifers. ...

Eddy Pazmino; Jacob Trauscht; Brittany Dame; William P. Johnson

2014-04-28T23:59:59.000Z

158

Plant and microbial controls on nitrogen retention and loss in a Humid Tropical Forest  

SciTech Connect

Humid tropical forests are generally characterized by the lack of nitrogen (N) limitation to net primary productivity, yet paradoxically have high potential for N loss. We conducted an intensive field experiment with {sup 15}NH{sub 4} and {sup 15}NO{sub 3} additions to highly weathered tropical forest soils to determine the relative importance of N retention and loss mechanisms. Over half of all the NH{sub 4}{sup +} produced from gross mineralization was rapidly converted to NO{sub 3}{sup -} during the process of gross nitrification. During the first 24 h plant roots took up 28 % of the N mineralized, dominantly as NH{sub 4}{sup +}, and were a greater sink for N than soil microbial biomass. Soil microbes were not a significant sink for added {sup 15}NH{sub 4}{sup +} or {sup 15}NO{sub 3}{sup -} during the first 24 hr, and only for {sup 15}NH{sub 4}{sup +} after 7 d. Patterns of microbial community composition, as determined by Terminal Restriction Fragment Length Polymorphism analysis, were weakly, but significantly correlated with nitrification and denitrification to N{sub 2}O. Rates of dissimilatory NO{sub 3}{sup -} reduction to NH{sub 4}{sup +} (DNRA) were high in this forest, accounting for up to 25 % of gross mineralization and 35 % of gross nitrification. DNRA was a major sink for NO{sub 3}{sup -} which may have contributed to the lower rates of N{sub 2}O and leaching losses. Despite considerable N conservation via DNRA and plant NH{sub 4}{sup +} uptake, the fate of approximately 45% of the NO{sub 3}{sup -} produced and 22% of the NH{sub 4}{sup +} produced were not measured in our fluxes, suggesting that other important pathways for N retention and loss (e.g., denitrification to N{sub 2}) are important in this system. The high proportion of mineralized N that was rapidly nitrified and the fates of that NO{sub 3}{sup -} highlight the key role of gross nitrification as a proximate control on N retention and loss in humid tropical forest soils. Furthermore, our results demonstrate the importance of the coupling between DNRA and plant uptake of NH{sub 4}{sup +} as a potential N conserving mechanism within tropical forests.

Templer, P.; Silver, W.; Pett-Ridge, J.; DeAngelis, K.M.; Firestone, M.K.

2009-09-15T23:59:59.000Z

159

Guidelines for acceptable soil concentrations in the old F- and H-Area Retention Basins  

SciTech Connect

Concentration guidelines for residual radionuclides in soil at the sites of the Old F- and H-Area Retention Basins (281-3F, 281-3H) have been calculated using a dose-based approach. The guidelines also are being applied to areas around the F-Basin`s Process Line. Estimation of these soil guidelines was completed using RESRAD 5.0 in accordance with the DOE RESRAD methodology specified in DOE/CH/8901 (Gi89). Guidelines are provided for the nuclides known to be present in the soils at each basin (Sc87). Soil and hydrologic characteristics specific to each basin are defined for the areas above, within, and beneath the contaminated zones.

Hamby, D.M.

1994-04-18T23:59:59.000Z

160

Colloids and Surfaces A: Physicochem. Eng. Aspects 289 (2006) 254255 Erratum to "Retention of mineral colloids in unsaturated  

E-Print Network (OSTI)

Colloids and Surfaces A: Physicochem. Eng. Aspects 289 (2006) 254­255 Erratum Erratum to "Retention. Physicochem. Eng. Aspects 256 (2005) 207­216) Gang Chen, Markus Flury Department of Crop and Soil Sciences.colsurfa.2006.06.029 #12;G. Chen, M. Flury / Colloids and Surfaces A: Physicochem. Eng. Aspects 289 (2006) 254

Flury, Markus

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Colloids and Surfaces A: Physicochem. Eng. Aspects 256 (2005) 207216 Retention of mineral colloids in unsaturated porous  

E-Print Network (OSTI)

Colloids and Surfaces A: Physicochem. Eng. Aspects 256 (2005) 207­216 Retention of mineral colloids theory, where removal of col- loidal particles from the fluid phase is governed by physico- chemical transport is also subject to physical constraint, i.e., colloid physical entrap- ment in pore throats

Flury, Markus

162

Nitrogen gas emissions from stormwater retention basins during wet weather events in the Phoenix Metropolitan area: an additional ecosystem service?  

E-Print Network (OSTI)

Nitrogen gas emissions from stormwater retention basins during wet weather events in the Phoenix Special thanks to all of our field and lab help: Rebecca Hale, Stevan Earl, Bony Ahmed, Lin Ye, Jolene. Samples were then taken throughout the day to assess water concentrations and gas losses (see photos

Hall, Sharon J.

163

The perceptions of novice and veteran teachers on the role of the principal in the retention of urban novice teachers  

E-Print Network (OSTI)

in the perceptions of novice and veteran teachers on the role of the principal in teacher retention. Participants for the study were selected from 15 elementary schools in an urban school district in the Southwestern part of the United States. The study included 270...

Sarpy-Simpson, Claudine L.

2007-04-25T23:59:59.000Z

164

O2, CH4 and CO2 gas retentions by acid smectites before and after thermal treatment  

Science Journals Connector (OSTI)

Acid smectites in natural condition and after thermal treatment up to 900 C were studied for their O2, CH4 and CO2 gas retentions at 25 C and 1 kg/cm2. Two smectites, one dioctahedral and one trioctahedral, wer...

C. Volzone; J. Ortiga

165

Neuroimaging for drug addiction and related behaviors  

SciTech Connect

In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

2011-10-01T23:59:59.000Z

166

Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis  

Science Journals Connector (OSTI)

......of structural features in chemicals associated with cancer drug...analyses of a large number of chemical features of drugs against...the most abundant microarray platform (HT-HG-U133A). The...times 11 327 genes. 2.2 Chemical descriptor datasets The chemical......

Suleiman A. Khan; Seppo Virtanen; Olli P. Kallioniemi; Krister Wennerberg; Antti Poso; Samuel Kaski

2014-09-01T23:59:59.000Z

167

GERMAN REFORMS AFFECT DRUG R&D  

Science Journals Connector (OSTI)

Under the national health care system, insurers pay for consumers' prescription drugs and get a 6% rebate from manufacturers to help contain costs; the remainder ... ...

PATRICIA SHORT

2003-09-01T23:59:59.000Z

168

Was Sherlock Holmes a Drug Addict?  

Science Journals Connector (OSTI)

... AN occasional correspondent contributes an amusing article to The Lancet of December 26 entitled Was Sherlock Holmes a Drug Addict?, as his friend Dr. Watson ...

1937-01-02T23:59:59.000Z

169

FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS  

E-Print Network (OSTI)

Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs ...

Flynn, Colleen A.

2011-12-31T23:59:59.000Z

170

Anion retention in soil: Possible application to reduce migration of buried technetium and iodine  

SciTech Connect

This report summarizes a literature review of our present knowledge of the anion exchange properties of a number of soils and minerals, which may potentially be used as anion exchangers to retard migration of such anions as iodide (I{sup {minus}}), iodate (IO{sub 3}{sup {minus}}) and pertechnetate (TcO{sub 4}{sup {minus}}) away from disposal site. The amorphous clays allophane and imogolite, are found to be among the most important soil components capable of developing appreciable amounts of positive charge for anion exchange even at about neutral pH. Decreases in the SiO{sub 2}/Al{sub 2}O{sub 3} ratio and soil pH result in an increase in soil AEC. Allophane and imogolite rich soils have an AEC ranging from 1 to 18 meq/100g at pH about 6. Highly weathered soils dominated by Fe and Al oxides and kaolinite may develop a significant amount of AEC as soil pH falls. The retention of iodine (I) and technetium ({Tc}), by soils is associated with both soil organic matter, and Fe and Al oxides, whereas sorption on layer silicate minerals in negligible. Fe and Al oxides become more important in the retention of anionic I{sup {minus}}, IO{sub 3}{sup {minus}}, and TcO{sub 4}{sup {minus}} as pH falls, since more positive charge is developed on the oxide surfaces. Although few studies, if any, have been conducted on I and {Tc} sorption by soil allophane and imogolite, it is estimated that a surface plough soil (2 million pounds soil per acre) with 5 meq/100g AEC, as is commonly found in andisols, shall retain approximately 5900 kg I and 4500 kg {Tc}. It is conceivable that an anion exchanger such as an andisol could be used to modify the near field environment of a radioactive waste disposal facility. This whole disposal system would then offer similar migration resistance to anions as is normally afforded to cations by usual and normal soils. 93 refs., 10 figs., 7 tabs.

Gu, B.; Schulz, R.K. (California Univ., Berkeley, CA (United States). Dept. of Soil Science)

1991-10-01T23:59:59.000Z

171

NONEQUILIBRIUM SULFUR CAPTURE AND RETENTION IN AN AIR COOLED SLAGGING COAL COMBUSTOR  

SciTech Connect

Calcium oxide injected in a slagging combustor reacts with the sulfur from coal combustion to form sulfur-bearing particles. They are deposited on the liquid slag layer on the combustor wall. Due to the low solubility of sulfur in slag, slag must be rapidly drained from the combustor to limit sulfur gas re-evolution. Analysis indicated that slag mass flow rates in excess of 400 lb/hr should limit sulfur re-evolution. The objective of this 42-month project was to perform a series of tests to determine the factors that control the retention of the sulfur in the slag. 36 days of testing on the combustor were completed prior to the end of this reporting period, 12/31/98. This compares with 16 tests required in the original project plan. Combustor tests in early 1997 with high (37%) ash, Indian coal confirmed that high slag mass flow rates of about 500 lb/hr resulted in retention in the slag of up to 20% of the injected sulfur content mineral matter. To further increase the slag flow rate, rice husks, which contain 20% ash, and rice husk char, which contain 70% ash, were co-fired with coal in the combustor. A series of 13 combustor tests were performed in fourth quarter of 1997 and a further 6 tests were performed in January 1998 and in the summer of 1998. The test objective was to achieve slag flow rates between 500 and 1,000 lb/hr. Due to the very low bulk density of rice husk, compared to pulverized coal, almost the entire test effort focused on developing methods for feeding the rice husks into combustor. In the last test of December 1997, a peak mineral matter, injection rate of 592 lb/hr was briefly achieved by injection of coal, rice husk char, gypsum, and limestone into the combustor. However, no significant sulfur concentration was measured in the slag removed from the combustor. The peak injection rate reached with biomass in the 1997 tests was 310 lb/hr with rice husk, and 584 lb/hr with rice husk char.

Dr. Bert Zauderer

1999-03-15T23:59:59.000Z

172

Network predicting drug's anatomical therapeutic chemical code  

Science Journals Connector (OSTI)

......validated on four drug datasets with various target...couple receptors and nuclear receptors. We found...well-collected drug datasets, the ATC-code assignments...For example, the dataset in Yamanishi et al...receptors (GPCRs) and nuclear receptors (NRs......

Yong-Cui Wang; Shi-Long Chen; Nai-Yang Deng; Yong Wang

2013-05-15T23:59:59.000Z

173

The World of Youthful Drug Use  

E-Print Network (OSTI)

they meet the fact that the use of drugs is illegal and exposes them to arrest and criminal prosecution. It was obvious that such kinds of information could be secured: only from the youths who were themselves in the drug using world. We could not rely on a...

Blumer, Herbert; Sutter, Alan; Smith, Roger; Ahmed, Samir

2000-04-01T23:59:59.000Z

174

Evaluation of in-vessel corium retention through external reactor vessel cooling for integral reactor  

SciTech Connect

In-vessel corium retention through external reactor vessel cooling (IVR-ERVC) for a small integral reactor has been evaluated to determine the thermal margin for the prevention of a reactor vessel failure. A thermal load analysis from the corium pool to the outer reactor vessel wall in the lower plenum of the reactor vessel has been performed to determine the heat flux distribution. The critical heat flux (CHF) on the outer reactor vessel wall has been determined to fix the maximum heat removal rate through the external coolant between the outer reactor vessel and the insulation of the reactor vessel. Finally, the thermal margin has been evaluated by comparison of the thermal load with the maximum heat removal rate of the CHF on the outer reactor vessel wall. The maximum heat flux from the corium pool to the outer reactor vessel is estimated at approximately 0.25 MW/m{sup 2} in the metallic layer because of the focusing effect. The CHF of the outer reactor vessel is approximately 1.1 MW/m{sup 2} because of a two phase natural circulation mass flow. Since the thermal margin for the IVR-ERVC is sufficient, the reactor vessel integrity is maintained during a severe accident of a small integral reactor. (authors)

Park, R. J.; Lee, J. R.; Kim, S. B.; Jin, Y.; Kim, H. Y. [Korea Atomic Energy Research Inst., 1045 Daedeok-daero, Yuseong-gu, Daejeon, 305-353 (Korea, Republic of)

2012-07-01T23:59:59.000Z

175

In-vessel coolability and retention of a core melt. Volume 2  

SciTech Connect

The efficacy of external flooding of a reactor vessel as a severe accident management strategy is assessed for an AP600-like reactor design. The overall approach is based on the Risk Oriented Accident Analysis Methodology (ROAAM), and the assessment includes consideration of bounding scenarios and sensitivity studies, as well as arbitrary parametric evaluations that allow the delineation of the failure boundaries. Quantification of the input parameters is carried out for an AP600-like design, and the results of the assessment demonstrate that lower head failure is physically unreasonable. Use of this conclusion for any specific application is subject to verifying the required reliability of the depressurization and cavity-flooding systems, and to showing the appropriateness (in relation to the database presented here, or by further testing as necessary) of the thermal insulation design and of the external surface properties of the lower head, including any applicable coatings. The AP600 is particularly favorable to in-vessel retention. Some ideas to enhance the assessment basis as well as performance in this respect, for applications to larger and/or higher power density reactors are also provided.

Theofanous, T.G.; Liu, C.; Additon, S.; Angelini, S.; Kymaelaeinen, O.; Salmassi, T. [California Univ., Santa Barbara, CA (United States). Center for Risk Studies and Safety

1996-10-01T23:59:59.000Z

176

Gas retention and release behavior in Hanford single-shell waste tanks  

SciTech Connect

This report describes the current understanding of flammable gas retention and release in Hanford single-shell waste tanks based on theory, experimental results, and observations of tank behavior. The single-shell tanks likely to pose a flammable gas hazard are listed and described, and photographs of core extrusions and the waste surface are included. The credible mechanisms for significant flammable gas releases are described, and release volumes and rates are quantified as much as possible. The only mechanism demonstrably capable of producing large ({approximately}100 m{sup 3}) spontaneous gas releases is the buoyant displacement, which occurs only in tanks with a relatively deep layer of supernatant liquid. Only the double-shell tanks currently satisfy this condition. All release mechanisms believed plausible in single-shell tanks have been investigated, and none have the potential for large spontaneous gas releases. Only small spontaneous gas releases of several cubic meters are likely by these mechanisms. The reasons several other postulated gas release mechanisms are implausible or incredible are also given.

Stewart, C.W.; Brewster, M.E.; Gauglitz, P.A.; Mahoney, L.A.; Meyer, P.A.; Recknagle, K.P.; Reid, H.C.

1996-12-01T23:59:59.000Z

177

Preliminary Study of Strong-Sludge Gas Retention and Release Mechanisms in Clay Simulants  

SciTech Connect

The Hanford Site has 28 double-shell tanks (DSTs) and 149 single-shell tanks (SSTs) containing radioactive wastes that are complex mixes of radioactive and chemical products. The mission of the Department of Energys River Protection Project is to retrieve and treat the Hanford tank waste for disposal and close the tank farms. A key aspect of the mission is to retrieve and transfer waste from the SSTs, which are at greater risk for leaking, into DSTs for interim storage until the waste is transferred to and treated in the Waste Treatment and Immobilization Plant. There is, however, limited space in the existing DSTs to accept waste transfers from the SSTs, and approaches to overcoming the limited DST space will benefit the overall mission. The purpose of this study is to summarize and analyze the key previous experiment that forms the basis for the relaxed controls and to summarize initial progress and results on new experiments focused on understanding the conditions that result in low gas retention. The work is ongoing; this report provides a summary of the initial findings. The previous large-scale test used about 50 m3 of sediment, which would be unwieldy for doing multiple parametric experiments. Accordingly, experiments will begin with smaller-scale tests to determine whether the desired mechanisms can be studied without the difficulty of conducting very large experiments.

Gauglitz, Phillip A.; Buchmiller, William C.; Probert, Samuel G.; Owen, Antionette T.

2010-10-12T23:59:59.000Z

178

Nanoparticle Agglomeration via Ionic Colloidal Destabilization as a Novel Approach to Dry Powder Formulations for Pulmonary Drug Delivery  

E-Print Network (OSTI)

Efficient administration of poorly water soluble drugs represents a leading challenge in pulmonary medicine. This route of administration has been used for steroidal treatments for some time, but with room for advancement. New inhalable medicines...

Plumley, Carl Joseph

2008-08-05T23:59:59.000Z

179

Evaluation of heterosis and heterosis retention in Bos taurus-Bos indicus crossbred cattle for productivity traits in cows  

E-Print Network (OSTI)

appreciation and gratitude to my committee chair, Dr. Sanders, and my committee members, Dr. Herring and Dr. Speed, who gave me support, guidance, and answers to my many questions from the moment I came to Texas A&M University. I would also like to thank my... of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE August 2005 Major Subject: Animal Breeding EVALUATION OF HETEROSIS AND HETEROSIS RETENTION IN BOS TAURUS -BOS INDICUS...

Meuchel, Meredith Christine

2005-11-01T23:59:59.000Z

180

Sorption of MS2 Bacteriophage to Layered Double Hydroxides: Effects of Reaction Time, pH, and Competing Anions  

E-Print Network (OSTI)

Sorption of MS2 Bacteriophage to Layered Double Hydroxides: Effects of Reaction Time, pBatch sorption and column breakthrough studies were conducted carbon could be used for virus removal. For example very high retention capacities for from an aqueous solution by bituminous coal (Oza and MS2. Sorption

Sparks, Donald L.

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Does UV disinfection compromise sutures? An evaluation of tissue response and suture retention in salmon surgically implanted with transmitters  

SciTech Connect

Ultraviolet radiation (UVR) can be used as a tool to disinfect surgery tools used for implanting transmitters into fish. However, the use of UVR could possibly degrade monofilament suture material used to close surgical incisions. This research examined the effect of UVR on monofilament sutures to determine if they were compromised and negatively influenced tag and suture retention, incision openness, or tissue reaction. Eighty juvenile Chinook salmon Oncorhynchus tshawytscha were surgically implanted with an acoustic transmitter and a passive integrated transponder. The incision was closed with a single stitch of either a suture exposed to 20 doses of UV radiation (5 minute duration per dose) or a new, sterile suture. Fish were then held for 28 d and examined under a microscope at day 7, 14, 21 and 28 for incision openness, ulceration, redness, and the presence of water mold. There was no significant difference between treatments for incision openness, redness, ulceration or the presence of water mold on any examination day. On day 28 post-surgery, there were no lost sutures; however, 2 fish lost their transmitters (one from each treatment). The results of this study do not show any differences in negative influences such as tissue response, suture retention or tag retention between a new sterile suture and a suture disinfected with UVR.

Walker, Ricardo W.; Brown, Richard S.; Deters, Katherine A.; Eppard, M. B.; Cooke, Steven J.

2013-10-01T23:59:59.000Z

182

Aerosol retention during SGTR meltdown sequences: Experimental insights of the effect of size and shape of the breach  

SciTech Connect

This paper summarizes the major insights gained from aerosol retention capability of a tube bundle that simulates the break stage of the secondary side of a failed steam generator under dry SGTR conditions. This scenario is highly relevant in nuclear safety since it affects the potential retention of radioactive particles in case of meltdown sequences with a SGTR. An 8-test experimental campaign has been carried out, extending the current database on the decontamination capability of the steam generator. The effects of the breach features (shape and size) and the particle nature (SiO{sub 2} and TiO{sub 2}) on the collection efficiency have been explored. The results confirmed the strong effect of the physical nature even when tube breaks in a fish-mouth mode. Loose aggregates (i.e. TiO{sub 2}) would be trapped to a limited extent (less than 25%); while single- or few-aggregates (i.e. SiO{sub 2}) would undergo a quite effective removal (i.e. over 75%). For fish-mouth breaches and SiO{sub 2} particles, the breach size has been found to moderately affect retention efficiency. Furthermore, the breach shape does not seem to have any effect on the net collection efficiency within the break stage, no matter the particle type. However, individual tube measurements indicate notably different deposition patterns, although an effect of the facility geometry cannot be disregarded as a key player in this observation. (authors)

Herranz, L. E.; Tardaguila, R. D.; Lopez, C. [Unit of Nuclear Safety Research, CIEMAT, Avd. Complutense, 22, 28040 Madrid (Spain)

2012-07-01T23:59:59.000Z

183

Controlling drug delivery across the placenta: A commentary  

E-Print Network (OSTI)

A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ...

Audus, Kenneth L.

1999-01-01T23:59:59.000Z

184

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network (OSTI)

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

185

Nano compartments may aid drug delivery, catalyst design > Archived...  

NLE Websites -- All DOE Office Websites (Extended Search)

Nano compartments may aid drug delivery, catalyst design April 18th, 2013 By Bill Steele Spongelike nanoparticles whose pores can be filled with drugs offer the promise of drug...

186

E-Print Network 3.0 - adverse antiepileptic drug Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... Dosage Same or different? A drug in a different...

187

Molecular Mechanisms of Drug Resistance Involving Ribonucleotide Reductase: Hydroxyurea Resistance in a Series of Clonally Related Mouse Cell Lines Selected in the Presence of Increasing Drug Concentrations  

Science Journals Connector (OSTI)

...processes that lead to the development of cells resistant to...mechanisms important in the development of drug resistance have...CDP as substrate and snake venom to hydrolyze the...37'C in the presence of snake venom. Both reactions...0.1 % SDS at room temperature, then 2 times for 30...

Bob K. Choy; Grant A. McClarty; Arthur K. Chan; Lars Thelander; and Jim A. Wright

1988-04-15T23:59:59.000Z

188

Optical measurement of drug concentrations in tissue  

SciTech Connect

This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The aim of this project was to develop noninvasive fiber-optic methods for measuring drug concentrations in tissue. Such a system would make possible the study of chemotherapy drug kinetics at specific, targeted locations in the body after the drug is administered. The major result of this project is the development of techniques for measuring changes in absorption of a medium with unknown scattering properties. The developed method was verified by testing on several media with scattering properties in the range typically found for tissue.

Mourant, J.R.; Bigio, I.J.; Jack, D.A.; Johnson, T.M.; Miller, H.D. [Los Alamos National Lab., NM (United States). Chemical Sciences and Technology Div.

1997-10-01T23:59:59.000Z

189

Data evaluation technical memorandum on the K-1407C Retention Basin at the Oak Ridge K-25 Site, Oak Ridge, Tennessee  

SciTech Connect

The K-1407-C Retention Basin was a surface impoundment at the Oak Ridge K-25 Site. The basin was used primarily for storing potassium hydroxide scrubber sludge generated at the K-25 Site. In addition, from 1960 to 1973, metal hydroxide sludges that were removed from the K-1407-B Holding Pond were discharged to the K-1407-C Retention Basin. The sludge in the K-1407-B Pond contained discharge from the K-1420 Decontamination and Uranium Recovery, the K-1501 Steam Plant, the K-1413 Laboratory, and the K-1401 Maintenance Building. Radioactive material is also present in the K-1407-C Retention Basin, probably the result of cleaning and decontamination activities at some of the aforementioned facilities. The discharge of waste materials to K-1407-C was discontinued before November of 1988, and all sludge was removed from the retention basin. Some of the sludge was stored, and the remainder was fixed in concrete. This report is specific to the K-1407-C Retention Basin and includes information pertinent to the evaluation of soil contamination. The focus of this evaluation is the effectiveness of the Phase 1 investigation of the K-1407-C Retention Basin to define site conditions adequately to support decisions regarding appropriate closure alternatives. This includes the physical characterization of the site area and the characterization of the nature and extent of contamination at the site in relation to risk characterization and statistical evaluation.

Beal, D.; Bock, J.; Hatmaker, T.; Zolyniak, J.; Goddard, P. (Oak Ridge K-25 Site, TN (United States)); Kucsmas, D. (Oak Ridge National Lab., TN (United States))

1991-10-01T23:59:59.000Z

190

Data evaluation technical memorandum on the K-1407C Retention Basin at the Oak Ridge K-25 Site, Oak Ridge, Tennessee. Environmental Restoration Program  

SciTech Connect

The K-1407-C Retention Basin was a surface impoundment at the Oak Ridge K-25 Site. The basin was used primarily for storing potassium hydroxide scrubber sludge generated at the K-25 Site. In addition, from 1960 to 1973, metal hydroxide sludges that were removed from the K-1407-B Holding Pond were discharged to the K-1407-C Retention Basin. The sludge in the K-1407-B Pond contained discharge from the K-1420 Decontamination and Uranium Recovery, the K-1501 Steam Plant, the K-1413 Laboratory, and the K-1401 Maintenance Building. Radioactive material is also present in the K-1407-C Retention Basin, probably the result of cleaning and decontamination activities at some of the aforementioned facilities. The discharge of waste materials to K-1407-C was discontinued before November of 1988, and all sludge was removed from the retention basin. Some of the sludge was stored, and the remainder was fixed in concrete. This report is specific to the K-1407-C Retention Basin and includes information pertinent to the evaluation of soil contamination. The focus of this evaluation is the effectiveness of the Phase 1 investigation of the K-1407-C Retention Basin to define site conditions adequately to support decisions regarding appropriate closure alternatives. This includes the physical characterization of the site area and the characterization of the nature and extent of contamination at the site in relation to risk characterization and statistical evaluation.

Beal, D.; Bock, J.; Hatmaker, T.; Zolyniak, J.; Goddard, P. [Oak Ridge K-25 Site, TN (United States); Kucsmas, D. [Oak Ridge National Lab., TN (United States)

1991-10-01T23:59:59.000Z

191

Digestion time  

NLE Websites -- All DOE Office Websites (Extended Search)

Digestion time Digestion time Name: Don Mancosh Location: N/A Country: N/A Date: N/A Question: I have always given the rule of thumb in class that material we eat is with us for about 24 hours before exiting the body. The question arises about the time value of liquids. Getting a big coke prior to a 3 hour drive generally means that there will be a stop along the way. Is there a generalization made about liquids in the body similar to the one for solid food? Replies: A physician would give a better answer, but I hazard this: the only liquids which people consume (deliberately) in significant quantities are water, ethyl alcohol and various oils. Water and alcohol are absorbed on a time scale of seconds to minutes through the mouth, stomach and digestive tract. The oils are huge molecules, so I'd guess like any other greasy food they get absorbed in the upper digestive tract. Some of them, perhaps the longest and most nonpolar, are not absorbed at all --- cf. the old-time remedy of mineral oil for constipation --- so there should be some average time-before-what's-left-is-excreted such as you're looking for, and my (wild) guess is that it would not differ substantially from that for food. You can define an average lifetime in the body for alcohol, since the natural level is zero. Rough guidelines are widespread in the context of drunk driving laws. But this is not really possible for water. One's body is normally full up to the brim with water, and there's no way for the body to distinguish between water molecules recently absorbed and molecules that've been moping around since the Beatles split up. Thus the water entering the toilet bowl after the pit stop is not in general the same water as was in the big coke. If you were to consider for water just the average time between drinking and peeing, it would seem to depend strongly on how well hydrated the body was before the drink, and how much was drunk. During sustained heavy exertion in the sun and dry air one can easily drink a pint of water an hour without peeing at all. On the other hand, if one is willing to drink enough water fast enough, so as to establish a high excess of body water one can pee 8 ounces 15 minutes or less after drinking 8 ounces.

192

Book Review of Handbook of Drug Metabolism. Second Edition  

Science Journals Connector (OSTI)

Book Review of Handbook of Drug Metabolism. ... This book is divided into four sections: Fundamentals, Factors Affecting Drug Metabolism, Technologies, and Applications. ...

Jeffrey P. Jones

2009-06-22T23:59:59.000Z

193

Apoferritin-based nanomedicine platform for drug delivery: equilibrium...  

NLE Websites -- All DOE Office Websites (Extended Search)

Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA. Apoferritin-based nanomedicine platform for drug delivery: equilibrium...

194

Drugs and oil flow through the Eagle Ford Shale.  

E-Print Network (OSTI)

??This report is a work of original reporting which investigates the proliferation of drug use and drug trafficking in the Eagle Ford Shale, a region (more)

Marks, Michael Perry

2014-01-01T23:59:59.000Z

195

Implementation Guidance, Drug Testing - December 3, 2007 | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Implementation Guidance, Drug Testing - December 3, 2007 Implementation Guidance, Drug Testing - December 3, 2007 December 3, 2007 Implementation guidance for applicants for, and...

196

Secretary Bodman's Memorandum Regarding Drug Testing at DOE ...  

Office of Environmental Management (EM)

Secretary Bodman's Memorandum Regarding Drug Testing at DOE Secretary Bodman's Memorandum Regarding Drug Testing at DOE September 14, 2007 In consideration of the report on the...

197

Alignment strategies for drug product process development and manufacturing .  

E-Print Network (OSTI)

??The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the (more)

Garvin, Christopher John

2012-01-01T23:59:59.000Z

198

Memorandum, Drug Testing at DOE - September 14, 2007 | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

on the Consequences of a Positive Drug Test Secretary Bodman's Memorandum Regarding Drug Testing at DOE Environment Worker Health & Safety Nuclear Safety Facility Safety Security...

199

E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...  

NLE Websites -- All DOE Office Websites (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

200

Mathematical Modeling of HIV-1 Infection and Drug Therapy  

E-Print Network (OSTI)

also discuss how drug treatment affects the emergence of drug resistance during treatment, and how a low level of virus and latently infected cells can persist in.

2008-12-16T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Drug Shows Promise for Advanced Disease  

Science Journals Connector (OSTI)

...session of the congress that the drug memantine significantly slowed the progression...transmit their signals. In contrast, memantine turns down the activity of the so-called...damage in Alzheimer's. In Germany, memantine has been approved for treating dementias...

Jean Marx

2000-07-21T23:59:59.000Z

202

NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM  

E-Print Network (OSTI)

Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

Hart, Steven N.

2011-02-22T23:59:59.000Z

203

Conflict of interest over Harvard drug  

Science Journals Connector (OSTI)

... an unusually candid statement released last week by Harvard Medical School, Dean Daniel C. Tosteson acknowledged that a "significant conflict of interest occurred" in a drug study undertaken by ...

Seth Shulman

1988-10-27T23:59:59.000Z

204

Pollution from drug manufacturing: review and perspectives  

Science Journals Connector (OSTI)

...19] and Europe [9,14] as pollution sources, with concentrations of...the picture of pharmaceutical pollution from manufacturing is still highly...for some drugs, possibly even air pollution. 2. Effect studies A number of...

2014-01-01T23:59:59.000Z

205

Female Team Overall Name Age Rank Time Rank Time Rank Time Pace Rank Time Rank Time Pace Time  

E-Print Network (OSTI)

Female Team Overall Name Age Rank Time Rank Time Rank Time Pace Rank Time Rank Time Pace Time 1 Amy:56:27.6 Deborah Mc Eligot Deborah Storrings Male Team Overall Name Age Rank Time Rank Time Rank Time Pace Rank Time Rank Time Pace Time 1 Macon Fessenden 20 1 5:42.2 2 0:26.9 1 34:29.7 3:23 1 0:12.8 1 17:41.1 3

Suzuki, Masatsugu

206

Temporal targets of drug action  

Science Journals Connector (OSTI)

...or Medicine recognized the role of the hypothalamus in orienting us in space. How does our orientation in time, in the same brain region, intersect with this system? The range of integrative signals between the master clock in the hypothalamus and peripheral...

Garret A. FitzGerald

2014-11-21T23:59:59.000Z

207

The Changing Face of Teenage Drug Abuse The Trend toward Prescription Drugs  

Science Journals Connector (OSTI)

...friends, or on the Internet." They can also get them all too easily from physicians, according to recent data from the National Center on Addiction and Substance Abuse at Columbia University. A 2004 survey of physicians found that 43 percent did not ask about prescription-drug abuse when taking a patient's... Dr. Richard Friedman describes an emerging pattern in drug use by teenagers: illicit street drugs such as ecstasy and cocaine are decreasing in popularity, whereas the nonmedical use of certain prescription drugs is on the rise.

Friedman R.A.

2006-04-06T23:59:59.000Z

208

FORMATION OF A PHYSICALLY STABLE AMORPHOUS DRUG COMPLEX  

E-Print Network (OSTI)

ABSTRACT In this paper we explore the use of Neusilin, an inorganic magnesium aluminometasilicate, to stabilize the amorphous form of an acidic drug a neutral drug and two basic drugs. Both cryomilling and ball milling of the drug with Neusilin were...

MacLean, Jenifer Anne

2010-12-16T23:59:59.000Z

209

Mahanaxar: quality of service guarantees in high-bandwidth, real-time streaming data storage  

SciTech Connect

Large radio telescopes, cyber-security systems monitoring real-time network traffic, and others have specialized data storage needs: guaranteed capture of an ultra-high-bandwidth data stream, retention of the data long enough to determine what is 'interesting,' retention of interesting data indefinitely, and concurrent read/write access to determine what data is interesting, without interrupting the ongoing capture of incoming data. Mahanaxar addresses this problem. Mahanaxar guarantees streaming real-time data capture at (nearly) the full rate of the raw device, allows concurrent read and write access to the device on a best-effort basis without interrupting the data capture, and retains data as long as possible given the available storage. It has built in mechanisms for reliability and indexing, can scale to meet arbitrary bandwidth requirements, and handles both small and large data elements equally well. Results from our prototype implementation shows that Mahanaxar provides both better guarantees and better performance than traditional file systems.

Bigelow, David [Los Alamos National Laboratory; Bent, John [Los Alamos National Laboratory; Chen, Hsing - Bung [Los Alamos National Laboratory; Brandt, Scott [UCSC

2010-01-01T23:59:59.000Z

210

Time Brightness  

NLE Websites -- All DOE Office Websites (Extended Search)

Perlmutter, et al., in Thermonuclear Supernovae, NATO ASI, v. 486 (1997) Perlmutter, et al., in Thermonuclear Supernovae, NATO ASI, v. 486 (1997) Cosmology from . . . Time Brightness ... . . . 50-100 Fields Lunar Calendar Scheduled Follow-Up Imaging at Hubble, Cerro Tololo, WIYN, Isaac Newton Scheduled Follow-Up Spectroscopy at Keck Almost 1000 Galaxies per Field RESULT: ~24 Type Ia supernovae discovered while still brightening, at new moon Berkeley Lab Keck WIYN Cerro Tololo Isaac Newton Hubble Strategy We developed a strategy to guarantee a group of supernova discoveries on a certain date. Just after a new moon, we observe some 50 to 100 high-galactic lattitute fields-each containing almost a thousand high-redshift galaxies-in two nights on the Cerro Tololo 4-meter telescope with Tyson & Bernstein's wide-field camera. We return three weeks later to observe the same

211

Using a drug-word Stroop task to differentiate recreational from dependent drug use  

E-Print Network (OSTI)

, Garavan H. A consistent attentional bias for drug-related material in active cocaine users across word and picture versions of the emotional Stroop task. Drug Alcohol Depend. 2006;81(3):251257. 38. Franken IHA, Kroon LY, Wiers RW, Jansen A. Selective...

Smith, Dana G.; Ersche, Karen D.

2014-03-14T23:59:59.000Z

212

Retention and management of stormwater runoff with rain gardens and rainwater harvesting systems.  

E-Print Network (OSTI)

??The alteration of natural flow regimes associated with land use change increases the volume of stormwater runoff and peak flows, and reduces the time to (more)

Schlea, Derek Alan

2011-01-01T23:59:59.000Z

213

The influence of anti-viral drug therapy on the evolution of HIV-1 ...  

E-Print Network (OSTI)

the infected steady states are shown for the case when the viral production rate ... time t, and V (t) denotes the population of infectious virus at t. s is the recruitment ...... [1] Z. Feng, J. Curtis, and D. Minchella, The influence of drug treatment on...

2006-08-05T23:59:59.000Z

214

Unibody coreshell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging  

Science Journals Connector (OSTI)

Abstract Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody coreshell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. By conjugating Gd3+ at the stable core and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we developed a theranostic \\{NPs\\} (UCS-Gd-Dox) that achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1=0.9 and 14.5mm?1s?1 at pH 7.4 and 5.5, respectively). The anti-cancer effect of UCS-Gd-Dox is significantly better than free Dox in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. To the best of our knowledge, this is the simplest approach to obtain the theranostic \\{NPs\\} with Gd-conjugation and Dox doping.

Lin-Chen Ho; Chao-Hsiung Hsu; Chung-Mao Ou; Chia-Wei Wang; Tsang-Pai Liu; Lian-Pin Hwang; Yung-Ya Lin; Huan-Tsung Chang

2015-01-01T23:59:59.000Z

215

Drug Testing for New Clearance Holders  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Drug Testing Prerequisite for DOE Security Clearance Applicants Drug Testing Prerequisite for DOE Security Clearance Applicants The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Current Status Clearance Action Test Required? Uncleared - Applicant Grant (Q/L, T/S/C) Yes Previously Cleared DOE-now uncleared DOE Reinstate (Q/L, T/S/C) Yes* Coming from another Federal agency, regardless of clearance status Grant (Q/L, T/S/C) Yes**

216

Drug Testing for New Clearance Holders  

NLE Websites -- All DOE Office Websites (Extended Search)

Drug Testing Prerequisite for DOE Security Clearance Applicants Drug Testing Prerequisite for DOE Security Clearance Applicants The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Current Status Clearance Action Test Required? Uncleared - Applicant Grant (Q/L, T/S/C) Yes Previously Cleared DOE-now uncleared DOE Reinstate (Q/L, T/S/C) Yes* Coming from another Federal agency, regardless of clearance status Grant (Q/L, T/S/C) Yes**

217

Protein-Based Nanomedicine Platforms for Drug Delivery  

SciTech Connect

Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drugs efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein based drug delivery system.

Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

2009-08-03T23:59:59.000Z

218

Web Sites with Misinformation about Illicit Drugs  

Science Journals Connector (OSTI)

To the Editor: As part of our research on the relation between the Internet and substance abuse, we have identified several Web sites that promulgate information about illicit drugs. These "partisan" Web sites are easily identified by common search engines if one uses the names of illicit substances... To the Editor: As part of our research on the relation between the Internet and substance abuse, we have identified several Web sites that promulgate information about illicit drugs. These partisan Web sites are easily identified by common search ...

2001-08-09T23:59:59.000Z

219

Prescription drug abuse: Problem, policies, andimplications  

Science Journals Connector (OSTI)

This article provides an overview on prescription drug abuse and highlights a number of related legislative bills introduced during the 112th Congress in response to this growing epidemic. Prescription drug abuse has emerged as thenations fastest growing drug problem. Although prescription drugs have been used effectively and appropriately for decades, deaths from prescription pain medicine in particular have reached epidemic proportions. Bills related to prescription drug abuse introduced during the 112th Congress focus on strengthening provider and consumer education, tracking and monitoring prescription drug abuse, improving data collection on drug overdose fatalities, combating fraud and abuse in Medicare and Medicaid programs, reclassifying drugs to make them more difficult to prescribe and obtain, and enforcing stricter penalties for individuals who operate scam pain clinics and sell pain pills illegitimately. This article underscores the importance of a multifaceted approach to combating prescription drug abuse and concludes with implications for nursing.

Janice Phillips

2013-01-01T23:59:59.000Z

220

Twelve or 30 Months of Dual Antiplatelet Therapy after Drug-Eluting Stents  

Science Journals Connector (OSTI)

...noncardiovascular causes of death. Statistical Analysis. The primary efficacy analysis was a superiority analysis performed with the use of the log-rank test, with stratification according to geographic region (North America, Europe, or Australia and New Zealand), thienopyridine drug received at the time... Patients who had received a drug-eluting stent and then dual antiplatelet therapy for 12 months were randomly assigned to 18 more months of therapy or aspirin alone. Continued therapy resulted in lower rates of stent thrombosis and major adverse cardiovascular events but more bleeding.

Mauri L.; Kereiakes D.J.; Yeh R.W.

2014-12-04T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Carbon Sequestration in Subtropical Oxisol Profiles: Retention Capacity and Effect of Soil Management  

Science Journals Connector (OSTI)

Recent studies in temperate regions have shown that the increase in C stocks in surface soil layers does not respond linearly to C addictions over time, due to a saturation of the sorption sites. The obtained res...

Deborah P. Dick; Ceclia S. Reis

2013-01-01T23:59:59.000Z

222

Charge Retention by Peptide Ions Soft-Landed onto Self-Assembled...  

NLE Websites -- All DOE Office Websites (Extended Search)

spectrometry or ex situ 15 keV Ga+ time-of-flight secondary ion mass spectrometry (ToF-SIMS). The results demonstrate that a fraction of multiply protonated peptide ions retain...

223

DOE/EA-1444: Environmental Assessment for the Construction of New Office Building, Child-Care Facility, Parking Garage, And Storm Water Retention Pond (September 2002)  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

4 4 ENVIRONMENTAL ASSESSMENT For the Construction of New Office Building, Child-Care Facility, Parking Garage, And Storm Water Retention Pond United States Department of Energy National Energy Technology Laboratory September 2002 DOE/EA-1444 ENVIRONMENTAL ASSESSMENT For the Construction of New Office Building, Child-Care Facility, Parking Garage, And Storm Water Retention Pond United States Department of Energy National Energy Technology Laboratory September 2002 National Environmental Policy Act (NEPA) Compliance Cover Sheet Proposed Action: The U.S. Department of Energy (DOE) proposes to upgrade facilities and infrastructure at the National Energy Technology Laboratory (NETL), Morgantown, WV, through acquisition of a 5-acre

224

Mechanisms of gas bubble retention and release: results for Hanford Waste Tanks 241-S-102 and 241-SY-103 and single-shell tank simulants  

SciTech Connect

Research at Pacific Northwest National Laboratory (PNNL) has probed the physical mechanisms and waste properties that contribute to the retention and release of flammable gases from radioactive waste stored in underground tanks at Hanford. This study was conducted for Westinghouse Hanford Company as part of the PNNL Flammable Gas Project. The wastes contained in the tanks are mixes of radioactive and chemical products, and some of these wastes are known to generate mixtures of flammable gases, including hydrogen, nitrous oxide, and ammonia. Because these gases are flammable, their retention and episodic release pose a number of safety concerns.

Gauglitz, P.A.; Rassat, S.D.; Bredt, P.R.; Konynenbelt, J.H.; Tingey, S.M.; Mendoza, D.P.

1996-09-01T23:59:59.000Z

225

Drug Innovation "Bridging Molecules and Diseases"  

E-Print Network (OSTI)

in the pharmaceutical industry. This focus area wishes to provide a knowledge and expertise platform, which platforms with the pharmaceutical industry are presently organized at three different levels: - Strategic, that allows high-level concerted drug research efforts in the molecular sciences, pharmaceutical sciences

Utrecht, Universiteit

226

2012 Women's Contraceptive Drugs and Devices List  

E-Print Network (OSTI)

as the health care reform law, will comply with requirements for Women's Preventive Health Services. This means2012 Women's Contraceptive Drugs and Devices List Aetna Student Health PlansSM Quality health plans plans effective or renewing after August 1, 2012 and subject to the Affordable Care Act, also known

Buehrer, R. Michael

227

Drug smuggling safety tests [July 1, 2006  

E-Print Network (OSTI)

enough to be utilized as drug carriers. Suslick adds that the three tests on mammalian cells they carried evidence of nano safety Login | Register Search: Site X-Ray Page 1 of 2X-Ray - Your Guide to All the Key X About Us | Contact Us | Privacy Policy | Terms & Conditions | Advertising | RSS Interested

Suslick, Kenneth S.

228

Human Cytomegalovirus Resistance to Antiviral Drugs  

Science Journals Connector (OSTI)

American Society for Microbiology MINIREVIEW MINIREVIEW Human...Resistance to Antiviral Drugs C. Gilbert 1 G. Boivin 1 Corresponding...523-528. 20 Boivin, G., C. Gilbert, A. Gaudreau, I. Greenfield...G., N. Goyette, C. Gilbert, N. Roberts, K. Macey...

C. Gilbert; G. Boivin

2005-03-01T23:59:59.000Z

229

Genomics-based drug discovery venture  

Science Journals Connector (OSTI)

Genomics-based drug discovery venture ... The Cambridge, Mass.-based company calls its DiscoverEase program "functional genomics"designed to isolate and rapidly determine not only genes but also the related functions of critical proteins. ... Other genomics programs sequence vast amounts of human genetic information. ...

ANN THAYER

1996-10-07T23:59:59.000Z

230

Genomics Rises To Drug Discovery Challenge  

Science Journals Connector (OSTI)

Genomics Rises To Drug Discovery Challenge ... Functional genomics and functional proteomics provide a set of powerful tools to help identify novel cellular targets ... With pharmaceutical companies and biotechnology firms always looking for ways to discover new medicines more quickly and more efficiently, they are increasingly turning to new genomics and proteomics technologies to speed things along. ...

STU BORMAN

1999-04-19T23:59:59.000Z

231

New Life for an Old Drug: the Anthelmintic Drug Niclosamide Inhibits Pseudomonas aeruginosa Quorum Sensing  

Science Journals Connector (OSTI)

...mellonella insect model of infection (33). Larvae of the wax moth G. mellonella are extremely sensitive to P. aeruginosa...2006. Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious...

Francesco Imperi; Francesco Massai; Cejoice Ramachandran Pillai; Francesca Longo; Elisabetta Zennaro; Giordano Rampioni; Paolo Visca; Livia Leoni

2012-12-17T23:59:59.000Z

232

Guidelines for acceptable soil concentrations in the Old F- and H-Area Retention Basins. Revision 1  

SciTech Connect

Concentration guidelines for residual radionuclides in soil at the sites of the Old F- and a Retention Basins (281-3F, 281-3H) have been calculated using a dose-based approach. The guidelines also are being applied to areas around the F-Basin`s Process Line. Estimation of these soil guidelines was completed using RESRAD 5.0 in accordance with the DOE RESRAD methodology specified in DOE/CH/8901 (Gi89). Guidelines are provided for the nuclides known to be present in the soils at each basin (Sc87). Soil and hydrologic characteristics specific to each basin are defined for the areas above, within, and beneath the contaminated zones.

Hamby, D.M.

1994-04-18T23:59:59.000Z

233

Deaths Involving MDMA and the Concomitant Use of Pharmaceutical Drugs  

Science Journals Connector (OSTI)

......are associated with chronic abuse resulting in chronic heart disease...maceutical drug, usually young males concurrently using ec...Micromedex Healthcare Series [Internet database]. 19742010. 20...Postmortem toxicology of drugs of abuse. Forensic Sci. Int. 142......

J.L. Pilgrim; D. Gerostamoulos; Olaf H. Drummer

2011-05-01T23:59:59.000Z

234

Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System  

E-Print Network (OSTI)

Hydrophobic drug paclitaxel nanoparticles (PAX NPs) and pH sensitive hydrogels were prepared in this study to build a colon targeting nanoparticle based drug delivery system for oral administration. Negative charged PAX NPs at the size of 110...

Yu, Xiao

2012-07-16T23:59:59.000Z

235

Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs  

E-Print Network (OSTI)

Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

Stauber, Zachary Jason

2012-01-01T23:59:59.000Z

236

Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...May 2014 review-article Minireview Energy Metabolism and Drug Efflux in Mycobacterium...availability of ATP. This suggests that energy metabolism and ATP production through...We also highlight the importance of energy metabolism in mediating drug tolerance...

Philippa A. Black; Robin M. Warren; Gail E. Louw; Paul D. van Helden; Thomas C. Victor; Bavesh D. Kana

2014-03-10T23:59:59.000Z

237

E-Print Network 3.0 - analyzing drug combination Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

, Saadat Anwar2 , Shanshan Liang2... : Identifying drug-drug interactions is a critical process in drug administration and ... Source: Baral, Chitta - Department of Computer...

238

E-Print Network 3.0 - antiviral drug resistance Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Opin Emerg Drugs . Author manuscript Emerging drugs for hepatitis B Summary: and to design new trials of combination therapy to delay drug resistance. In the future, antiviral...

239

E-Print Network 3.0 - anticancer drug levels Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Chemistry 7 Oxford University Press 2005 1 Discovering drug interactions: a text-mining and reasoning ap- Summary: is responsible for metabol- ism of drug B. Such drug...

240

E-Print Network 3.0 - anticancer drug topotecan Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

E-Print Network 3.0 - anticancer drugs mitoxantrone Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

242

E-Print Network 3.0 - anticancer drug roscovitine Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

243

E-Print Network 3.0 - anticancer drug mitoxantrone Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

244

Sexuality Under the Influence: The Queer Pleasures of Illicit Drugs in Transatlantic Gay and Lesbian Culture  

E-Print Network (OSTI)

of Illicit Drugs in Transatlantic Gay and Lesbian Culture Aof Illicit Drugs in Transatlantic Gay and Lesbian Culture byof Illicit Drugs in Transatlantic Gay and Lesbian Culture

Randolph, Patrick

2011-01-01T23:59:59.000Z

245

Nonequilibrium sulfur capture and retention in an air cooled slagging coal combustor. Quarterly technical progress report, 1996  

SciTech Connect

The objective of this 24 month project is to determine the degree of sulfur retention in slag in a full scale cyclone coal combustor with sulfur capture by calcium oxide sorbent injection into the combustor. This sulfur capture process consists of two steps: Capture of sulfur with calcined calcium oxide followed by impact of the reacted sulfur-calcium particles on the liquid slag lining the combustor. The sulfur bearing slag must be removed within several minutes from the combustor to prevent re-evolution of the sulfur from the slag. To accomplish this requires slag mass flow rates in the range of several 100 lb/hr. To study this two step process in the combustor, two groups of tests are being implemented. In the first group, calcium sulfate in the form of gypsum, or plaster of Paris, was injected in the combustor to determine sulfur evolution from slag. In the second group, the entire process is tested with limestone and/or calcium hydrate injected into the combustor. This entire effort consists of a series of up to 16 parametric tests in a 20 MMtu/hr slagging, air cooled, cyclone combustor. During the present quarterly reporting period ending September 30,1996, three tests in this project were implemented, bringing the total tests to 5. In addition, a total of 10 test days were completed during this quarter on the parallel project that utilizes the same 20 MMtu/hr combustor. The results of that project, especially those related to improved slagging performance, have a direct bearing on this project in assuring proper operation at the high slag flow rates that may be necessary to achieve high sulfur retention in slag.

Zauderer, B.

1996-11-01T23:59:59.000Z

246

Biogeochemical cycling in an organic-rich coastal marine basin. 7. Sulfur mass balance, oxygen uptake and sulfide retention  

SciTech Connect

Sulfur and oxygen fluxes were quantified in the seasonally varying anoxic marine sedimentary system of Cape Lookout Bight, N.C., U.S.A. Over the three year study period, 1981-1983, the mean annual sulfate reduction rate was determined to be 18.2 +/- 1.6 moles x m/sup -2/ x y/sup -1/. This value, added to the estimate of the detrital sulfur input of 1.2 +/- 4.4 gave a total sulfur input of 19.4 +/- 4.7 moles x m/sup -1/ x y/sup 2/)/sup 1/. The sulfide flux to the sediment-water interface, measured in anaerobic benthic chambers was 4.6 +/- 0.5 moles x m/sup -2/ x y/sup -1/, and represented 37% of the annual oxygen uptake rate of 25.2 +/- 2.8 moles x m/sup -2/ x y/sup -1/. The sulfide burial rate, determined to be 15.5 +/- 3.1 moles x m/sup -2/ x y/sup -1/, was within 5% of the value predicted by summing the fluxes at the sediment-water interface. The C/S weight ratio of sediment below the depth of diagenetic reaction was determined to be 2.75. The sulfide retention rate in these rapidly accumulating sediments (10 cm/yr) was 77 +/- 19%. Comparison of this result with previous studies shows that rapid sediment accumulation and the lack of bioturbation control this unusually high degree of sulfide retention.

Chanton, J.P.; Martens, C.S.

1987-05-01T23:59:59.000Z

247

PET IMAGING STUDIES IN DRUG ABUSE RESEARCH.  

SciTech Connect

There is overwhelming evidence that addiction is a disease of the brain (Leshner, 1997). Yet public perception that addiction is a reflection of moral weakness or a lack of willpower persists. The insidious consequence of this perception is that we lose sight of the fact that there are enormous medical consequences of addiction including the fact that a large fraction of the total deaths from cancer and heart disease are caused by smoking addiction. Ironically the medical school that educates physicians in addiction medicine and the cancer hospital that has a smoking cessation clinic are vanishingly rare and efforts at harm reduction are frequently met with a public indignation. Meanwhile the number of people addicted to substances is enormous and increasing particularly the addictions to cigarettes and alcohol. It is particularly tragic that addiction usually begins in adolescence and becomes a chronic relapsing problem and there are basically no completely effective treatments. Clearly we need to understand how drugs of abuse affect the brain and we need to be creative in using this information to develop effective treatments. Imaging technologies have played a major role in the conceptualization of addiction as a disease of the brain (Fowler et al., 1998a; Fowler et al., 1999a). New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology and medicine. This topic cuts across the medical specialties of neurology, psychiatry, cancer and heart disease because of the high medical, social and economic toll that drugs of abuse, including and especially the legal drugs, cigarettes and alcohol, take on society. In this chapter we will begin by highlighting the important role that chemistry has played in making it possible to quantitatively image the movement of drugs as well as their effects on the human brain. This will be followed by highlights of PET studies of the acute effects of the psychostimulant drugs cocaine and methylphenidate (ritalin) and studies of the chronic effects of cocaine and of tobacco smoke on the human brain. This chapter concludes with the description of a study which uses brain imaging coupled with a specific pharmacological challenge to address the age-old question of why some people who experiment with drugs become addicted while others do not.

Fowler, J.S.; Volkow, N.D.; Ding, Y.S.; Logan, J.; Wang, G.J.

2001-01-29T23:59:59.000Z

248

The Role of Pore Size and Stationary Phase Composition in Preventing Aqueous-Induced Retention Time Loss in Reversed-Phase HPLC  

Science Journals Connector (OSTI)

......thank John Henderson, Jr., who did some early...York, NY, 1993. 2. R.K. Gilpin and M...407782 (1984). 4. R.G. Bogar, J.C...1986). 7. M.E. McNally and L.B. Rogers...E. Montgomery, Jr. and M.J. Wirth...K. Kazakevich, R. LoBrutto, F. Chan......

Brian A. Bidlingmeyer; Alan D. Broske

249

Evaluating the Impact of Embodied Conversational Agents (ECAs) Attentional Behaviors on User Retention of Cultural Content in a Simulated Mobile Environment  

Science Journals Connector (OSTI)

The paper presents an evaluation study of the impact of an ECA's attentional behaviors using a custom research method that combines facial expression analysis, eye-tracking and a retention test. The method provides additional channels to EEG-based methods ... Keywords: embodied conversational agents (ecas), eye tracking

Ioannis Doumanis, Serengul Smith

2014-11-01T23:59:59.000Z

250

Drug-Free Federal Workplace Testing Implementation Program  

Directives, Delegations, and Requirements

The order provides guidance and policy for the administration, application and implementation of the DOE Drug-free Federal Workplace Plan and other regulations that facilitate the maintenance of a drug-free Federal workplace through the establishment of programs to test for the use of illegal drugs. Chg 1, dated 8-21-92

1988-07-29T23:59:59.000Z

251

Division of Human Resources Alcohol & Drug Testing (CDL)  

E-Print Network (OSTI)

Division of Human Resources Alcohol & Drug Testing (CDL) Definitions of Terms Employee Relations/Alcohol & Drug Testing (CDL) Questions: (813) 974-2970 Rev. 12/2008 The definitions listed below are for common words/phrases used in the alcohol and drug testing procedures. Accident - An occurrence associated

Meyers, Steven D.

252

The University of Mississippi Drug and Alcohol Testing  

E-Print Network (OSTI)

The University of Mississippi Drug and Alcohol Testing Summary/Purpose: In furtherance of the University's interest to maintain a drug-free workplace, the University reserves the right to test any of the University's interest to maintain a drug-free workplace, the University reserves the right to test any

Tchumper, Gregory S.

253

Model-Based Dependability Analysis of Programmable Drug Infusion Pumps  

E-Print Network (OSTI)

Model-Based Dependability Analysis of Programmable Drug Infusion Pumps Sriram Sankaranarayanan.lastname@colorado.edu Abstract. Infusion pumps are commonly used in home/hospital care to inject drugs into a patient a case-study involving an infusion pump used to manage pain through the infusion of analgesic drugs

Sankaranarayanan, Sriram

254

Media's Positive and Negative Frames in Reporting Celebrity Deaths From Illegal Drug Overdoses Versus Prescription Drug Overdoses  

E-Print Network (OSTI)

This study compared the celebrity illegal drug overdose deaths of River Phoenix, Chris Farley, and Brad Renfro to the prescription drug overdose deaths of Anna Nicole Smith, Heath Ledger, and Brittany Murphy. This research used quantitative...

Wood, Michelle

2011-12-31T23:59:59.000Z

255

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network (OSTI)

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

256

High-Cost Generic Drugs Implications for Patients and Policymakers  

Science Journals Connector (OSTI)

It is well known that new brand-name drugs are often expensive, but U.S. health care is also witnessing a lesser-known but growing and seemingly paradoxical phenomenon: certain older drugs, many of which are generic and not protected by patents or market exclusivity, are now also extremely expensive... Some older generic drugs have become very expensive, owing to factors including drug shortages, supply disruptions, and consolidations in the generic-drug industry. But generics manufacturers that legally obtain a market monopoly can also unilaterally raise prices.

Alpern J.D.Stauffer W.M.Kesselheim A.S.

2014-11-13T23:59:59.000Z

257

Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer  

Science Journals Connector (OSTI)

...Molecular Targets, and Chemical Biology Nanoparticle Targeting of Anticancer Drug Improves...14263. Prior studies suggested that nanoparticle drug delivery might improve the therapeutic...responses not possible with a free drug. Nanoparticle|drug delivery|PAMAM dendrimer...

Jolanta F. Kukowska-Latallo; Kimberly A. Candido; Zhengyi Cao; Shraddha S. Nigavekar; Istvan J. Majoros; Thommey P. Thomas; Lajos P. Balogh; Mohamed K. Khan; James R. Baker, Jr.

2005-06-15T23:59:59.000Z

258

Continuous-time random-walk model of transport in variably saturated heterogeneous porous media  

Science Journals Connector (OSTI)

We propose a unified physical framework for transport in variably saturated porous media. This approach allows fluid flow and solute migration to be treated as ensemble averages of fluid and solute particles, respectively. We consider the cases of homogeneous and heterogeneous porous materials. Within a fractal mobile-immobile continuous time random-walk framework, the heterogeneity will be characterized by algebraically decaying particle retention times. We derive the corresponding (nonlinear) continuum-limit partial differential equations and we compare their solutions to Monte Carlo simulation results. The proposed methodology is fairly general and can be used to track fluid and solutes particles trajectories for a variety of initial and boundary conditions.

Andrea Zoia; Marie-Christine Nel; Andrea Cortis

2010-03-04T23:59:59.000Z

259

Extension of the Isobolographic Approach to Interactions Studies between More than Two Drugs: Illustration  

E-Print Network (OSTI)

received the drugs separately or in various combinations. Drug infusion was stopped at the onset of maximal

Gelman, Andrew

260

A review of age-old antimalarial drug to combat malaria: efficacy up-gradation by nanotechnology based drug delivery  

Science Journals Connector (OSTI)

Abstract Malaria is uncontrolled burden in the world till now. Despite of different efforts to develop antimalarial drug for decades, any anti-malarial drug can able to eradicate completely till now. Many anti-malarial substances are practically ineffectual because of their physicochemical limitations, cytotoxicity, chemical instability and degradation, and limited activities against intracellular parasites. Taking into consideration, the amount of research is going to conduct in the field of nanoparticle based drug delivery systems, lead to new ways of improving the treatment of infectious diseases. The study has focused on the progress and advancement of research on nanotechnology based drug delivery to eradicate the malaria. We like to focus the efficacy of nanotechnology based drug application for the opening out of novel chemotherapeutics in laboratory research, which may show the way to better use with age-old antimalarial drug and may draw the attention of pharmaceutical industries for the improvement and designing of effective anti-malarial drugs in future.

Satyajit Tripathy; Somenath Roy

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Molecular mechanism of an adverse drugdrug interaction of allopurinol and furosemide in gout treatment  

Science Journals Connector (OSTI)

Abstract Gout patients receiving a combination of allopurinol and furosemide require higher allopurinol doses to achieve the target serum urate (SU) of gout patients is based on two further complementary mechanisms, the direct inhibition of XO activity by the allopurinol metabolite oxypurinol and a down-regulation of XO protein expression. The latter is compromised by addition of furosemide and might explain why patients receiving furosemide therapy require higher allopurinol doses. miR-448 was identified as a potential drug-dependent XO regulator. Finally, down-regulation of AMPK protein expression in HRCE cells by administration of oxypurinol/furosemide reveals a possible new mechanism of renal drug-induced hyperuricemia.

Claudia Knake; Lisa Stamp; Andrew Bahn

2014-01-01T23:59:59.000Z

262

Charge Retention by Gold Clusters on Surfaces Prepared Using Soft Landing of Mass Selected Ions  

SciTech Connect

Monodisperse gold clusters have been prepared on surfaces in different charge states through soft landing of mass-selected ions. Ligand-stabilized gold clusters were prepared in methanol solution by reduction of chloro(triphenylphosphine)gold(I) with borane tert-butylamine complex in the presence of 1,3-bis(diphenylphosphino)propane. Electrospray ionization was used to introduce the clusters into the gas-phase and mass-selection was employed to isolate a single ionic cluster species (Au11L53+, L = 1,3-bis(diphenylphosphino)propane) which was delivered to surfaces at well controlled kinetic energies. Using in-situ time of flight secondary ion mass spectrometry (TOF-SIMS) it is demonstrated that the Au11L53+ cluster retains its 3+ charge state when soft landed onto the surface of a 1H,1H,2H,2H-

Johnson, Grant E.; Priest, Thomas A.; Laskin, Julia

2012-01-24T23:59:59.000Z

263

Magnetic Silica Nanotubes: Synthesis, Drug Release, and Feasibility for Magnetic Hyperthermia  

Science Journals Connector (OSTI)

Magnetic Silica Nanotubes: Synthesis, Drug Release, and Feasibility for Magnetic Hyperthermia ... After removal of RhB@?-Fe2O3@SiO2 by magnet, 3 mL of the clear solution was extracted with a syringe at given time intervals and then analyzed by UVvis spectroscopy at a wavelength of 4001000 nm. ... The work was supported by Foundation for Polish Science within Focus with contract F4/2010. ...

Xuecheng Chen; Rdiger Klingeler; Matthias Kath; Ahmed A. El Gendy; Krzysztof Cendrowski; Ryszard J. Kalenczuk; Ewa Borowiak-Palen

2012-04-09T23:59:59.000Z

264

Improving cancer treatment with cyclotron produced radionuclides. [Multiple Drug Resistance (MDR)  

SciTech Connect

The overall objective of this work was to promote nuclear medicine applications in oncology. This is being done by improving the scientific basis of diagnosis, treatment and treatment follow-up with cyclotron-produced tracers. For diagnostic use, positron-emitting isotopes such as Ga-66 and I-124 are being used. Initial studies on the characterization of He-4 particle energies required for Ga-66 production have been completed. Parameters for I-124 radiolabelling of monoclonal antibodies have been determined; the labelled antibodies have been used in animal studies using positron emission tomography (PET) to quantify antibody concentration within tumors in vivo. Imaging physics studies have demonstrated that I-124 can be quantitatively imaged by PET, even in the presence of 100-told greater concentrations of I-131. Measurement of concentrations of label in vivo has been accomplished in nuclei mice bearing neuroblastoma tumors and nude rats bearing human ovarian cancer cells. These studies have major implications for both the quantification of dosimetry and quantification kinetic assessment of anti-tumor antibody localization in vivo. For treatment of tumors, F-18 has been incorporated in 2-fluoro-2-deoxy glucose and 5-fluoro uridine, and O-15 labelled water has been produced. Reagents incorporating C-11 and N-13 are under development. In a related area, C-14 labelled colchicine is being studied as a means of assaying cells for multiple drug resistance (MDR). Cells expressing MDR are shown to retain significantly less C-14 colchiene. This suggest that colchiene retention may be of useful probe in modelling and studying MDR development in human tumors. The precursor required for producing C-11 colchicine has also been synthesized. 11 refs. (MHB)

Larson, S.M.; Finn, R.D.

1990-10-15T23:59:59.000Z

265

Precision Timed Machines  

E-Print Network (OSTI)

1.4 Precision Timed Machines . . . . .Precision Timed Machine 2.1precision timed (PRET) machine. pages 264265, June 2007. [

Liu, Isaac Suyu

2012-01-01T23:59:59.000Z

266

A Time of Scary Opportunity Stephen R. Forrest  

E-Print Network (OSTI)

manufacturing, green energy, and health care and drug discovery are a few examples. Among these, advanced government, business and educational institutions) take steps that may seem risky, but which will prove beneficial over time. If we act boldly, use our imaginations and our energy, then we can take advantage

Shyy, Wei

267

Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors  

Science Journals Connector (OSTI)

...mum of tissue, using a 543 excitation laser and LP 560 emission filter. A plane approximately...to local tumors can be thought of as the fusion of 2 traditional approaches to drug delivery...Ther 2010;9:1798-808. 11. Dvorak HF , Nagy JA, Dvorak JT Dvorak AM.Identification...

Ashley A. Manzoor; Lars H. Lindner; Chelsea D. Landon; Ji-Young Park; Andrew J. Simnick; Matthew R. Dreher; Shiva Das; Gabi Hanna; Won Park; Ashutosh Chilkoti; Gerben A. Koning; Timo L.M. ten Hagen; David Needham; and Mark W. Dewhirst

2012-11-01T23:59:59.000Z

268

1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds  

E-Print Network (OSTI)

proteins including enzymes, ion channels, GPCRs and nuclear receptors. However, current drug and nuclear receptors [5]. Publicly available databases have been built and maintained, such as KEGG BRITE [6 using chemical and interaction information about known compounds in the dataset. The WNN method can

Marchiori, Elena

269

Quantitative Selected Ion Monitoring (QSIM) of Drugs and/or Drug Metabolites in Biological Matrices  

Science Journals Connector (OSTI)

......continued. Substance Thiothixene Haloperidol Lithium Trazodone Hormones Testosterone 5n...Table I were chosen based on ease of synthesis. The one exception was amitriptyline-d6...deactivated by injecting aliquots of an ethyl acetate extract of a drug-free matrix. Aliquots......

W.A. Garland; M.L. Powell

1981-08-01T23:59:59.000Z

270

Modeling of the Time-Dependency of in Vitro Drug Cytotoxicity and Resistance  

Science Journals Connector (OSTI)

...The experimental and modeling results from our study...DW2); and (c) rapid uptake and strong binding...reported data (29), the simulations show that RTX, MTX...universal PD candidate for modeling the growth inhibitory...using high-resolution automated image analysis. Cytometry...

Laurence M. Levasseur; Harry K. Slocum; Youcef M. Rustum; and William R. Greco

1998-12-15T23:59:59.000Z

271

Real-time Fluorescent Resonance Energy Transfer Analysis to Monitor Drug Resistance in Chronic Myelogenous Leukemia  

Science Journals Connector (OSTI)

...and dasatinib (bottom) to provide a pharmaceutical signature for...simply identify the Bcr-Abl fusion oncogene but provide no useful information with regard...therapeutic development, could provide the necessary technology to push...

Ahmet Tunceroglu; Michiyuki Matsuda; and Raymond B. Birge

2010-11-01T23:59:59.000Z

272

Real-time Fluorescent Resonance Energy Transfer Analysis to Monitor Drug Resistance in Chronic Myelogenous Leukemia  

Science Journals Connector (OSTI)

...NH2-terminal YFP (yellow mutant of green fluorescent protein) and a COOH-terminal CFP (cyan mutant of green fluorescent protein). However...conformation change and yielding an energy transfer from CFP to YFP. To...pair of fluorescent resonance energy transfer-based probes for...

Ahmet Tunceroglu; Michiyuki Matsuda; and Raymond B. Birge

2010-11-01T23:59:59.000Z

273

Light Sources Help Discover New Drug Against Melanoma | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma July 18, 2011 - 12:07pm Addthis The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. Mike Ross Science Writer at SLAC National Accelerator Laboratory What does this mean for me? A new drug designed to fight melanoma was discovered thanks to the

274

Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 September 1, 2011 The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Matrix, Drug Testing for DOE security clearance - September 1, 2011

275

DOE Laboratories Help Develop Promising New Cancer Fighting Drug,  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Laboratories Help Develop Promising New Cancer Fighting Drug, Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm Addthis Powerful X-Rays Enable Development of Successful Treatment for Melanoma and Other Life-Threatening Diseases WASHINGTON, DC - Powerful X-ray technology developed at the U.S. Department of Energy's (DOE's) national laboratories is revealing new insights into diseases ranging from Alzheimer's to the swine flu, and, most recently, enabled the discovery of a groundbreaking new drug treatment for malignant melanoma, the deadliest form of skin cancer. The drug, Zelboraf (vemurafenib), received Food and Drug Administration (FDA) approval on Wednesday. In showing the structures of diseased and

276

DOE Laboratories Help Develop Promising New Cancer Fighting Drug,  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Laboratories Help Develop Promising New Cancer Fighting Drug, Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm Addthis Powerful X-Rays Enable Development of Successful Treatment for Melanoma and Other Life-Threatening Diseases WASHINGTON, DC - Powerful X-ray technology developed at the U.S. Department of Energy's (DOE's) national laboratories is revealing new insights into diseases ranging from Alzheimer's to the swine flu, and, most recently, enabled the discovery of a groundbreaking new drug treatment for malignant melanoma, the deadliest form of skin cancer. The drug, Zelboraf (vemurafenib), received Food and Drug Administration (FDA) approval on Wednesday. In showing the structures of diseased and

277

Hippocampal ``Time Cells'': Time versus Path Integration  

E-Print Network (OSTI)

Neuron Article Hippocampal ``Time Cells'': Time versus Path Integration Benjamin J. Kraus,1 function of hippocampal networks (Etienne and Jeffery, 2004; McNaughton et al., 1991, 1996, 2006; O

Hasselmo, Michael

278

Time in quantum mechanics  

E-Print Network (OSTI)

OF CONTENTS I. INTRODUCTION II. HISTORICAL DEVELOPMENT A. Classical Mechanics B. Quantum Theory . C. The Problem 3 4 6 III. TIME ATOMS AND DISCRETE TIME A. The Earliest Applications of Atomistic and Discrete Time . . . . . B. The Radiating Electron... . C. Quantum Field Theory 8 10 l2 IV. TIME OPERATOR FORMULATIONS 16 A. Advocates Against a Time Operator . B. The Possibility of a Time Operator C, Advocates in Favor of a Time Operator D. A Restricted Time Delay Operator: Scattering Theory...

Chapin, Kimberly R.

2012-06-07T23:59:59.000Z

279

Factors Associated with Recruitment and Retention Rates of Minority Youth 4-H Members as Perceived by Adult Club Leaders and County Extension Agents in Texas  

E-Print Network (OSTI)

FACTORS ASSOCIATED WITH RECRUITMENT AND RETENTION RATES OF MINORITY YOUTH 4-H MEMBERS AS PERCEIVED BY ADULT CLUB LEADERS AND COUNTY EXTENSION AGENTS IN TEXAS A Thesis by NICOLE ANN GONZALES Submitted to the Office of Graduate.... Holub Head of Department, Jack Elliot December 2012 Major Subject: Agricultural Leadership, Education, and Communications Copyright 2012 Nicole Ann Gonzales ii ABSTRACT According to enrollment data from the National 4-H Headquarters...

Gonzales, Nicole 1989-

2012-12-05T23:59:59.000Z

280

Evaluation of the 3M Organic Vapor Monitor #3500 as a sampling device for ethyl acrylate and the effect of discontinued exposure on vapor retention  

E-Print Network (OSTI)

Sampling Theories of Adsorption Forces of Adsorption Activation Procedures Surface Structure Statement of Hypotheses METHODOLOGV Test Atmosphere Generation Exposure Chamber MIRAN Calibration and Use Monitor Exposure to EA Analytical Procedures...EVALUATION OF THE 3M ORGANIC VAPOR MONITOR 53500 AS A SAMPLING DEVICE FOR ETHYL ACRYLATE AND THE EFFECT OF DISCONTINUED EXPOSURE ON VAPOP, RETENTION A Thesis by ROBERT WAYNE BARR Submitted to the Graduate College of Texas Al!M University...

Barr, Robert Wayne

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Analysis of possible future atmospheric retention of fossil fuel CO/sub 2/  

SciTech Connect

This report investigates the likely rates and the potential range of future CO/sub 2/ emissions, combined with knowledge of the global cycle of carbon, to estimate a possible range of future atmospheric CO/sub 2/ concentrations through the year 2075. Historic fossil fuel usage to the present, growing at a rate of 4.5% per year until 1973 and at a slower rate of 1.9% after 1973, was combined with three scenarios of projected emissions growth ranging from approximately 0.2 to 2.8% per year to provide annual CO/sub 2/ emissions data for two different carbon cycle models. The emissions scenarios were constructed using an energy-economic model and by varying key parameters within the bounds of currently expected future values. The extreme values for CO/sub 2/ emissions in the year 2075 are 6.8 x 10/sup 15/ and 91 x 10/sup 15/ g C year/sup -1/. Carbon cycle model simulations used a range of year - 1800 preindustrial atmospheric concentrations of 245 to 292 ppM CO/sub 2/ and three scenarios of bioshere conversion as additional atmospheric CO/sub 2/ source terms. These simulations yield a range of possible atmospheric CO/sub 2/ concentrations in year 2075 of approximately 500 to 1500 ppM, with a median of about 700 ppM. The time at which atmospheric CO/sub 2/ would potentially double from the preindustrial level ranges from year 2025 to >2075. The practical, programmatic value of this forecast exercise is that it forces quantitative definition of the assumptions, and the uncertainties therein, which form the basis of our understanding of the natural biogeochemical cycle of carbon and both historic and future human influences on the dynamics of the global cycle. Assumptions about the possible range of future atmospheric CO/sub 2/ levels provide a basis on which to evaluate the implications of these changes on climate and the biosphere. 44 references, 17 figures, 21 tables.

Edmonds, J.A.; Reilly, J.; Trabalka, J.R.; Reichle, D.E.

1984-09-01T23:59:59.000Z

282

Mechanisms of gas retention and release: Experimental results for Hanford single-shell waste tanks 241-A-101, 241-S-106, and 241-U-103  

SciTech Connect

The 177 underground waste storage tanks at the Hanford Site contain millions of gallons of radioactive waste resulting from the purification of nuclear materials and related processes. Through various mechanisms, flammable gas mixtures of hydrogen, ammonia, methane, and nitrous oxide are generated and retained in significant quantities within the waste in many ({approximately}25) of these tanks. The potential for large releases of retained gas from these wastes creates a flammability hazard. It is a critical component of the effort to understand the flammability hazard and a primary goal of this laboratory investigation to establish an understanding of the mechanisms of gas retention and release in these wastes. The results of bubble retention experimental studies using waste samples from several waste tanks and a variety of waste types support resolution of the Flammable Gas Safety Issue. Gas bubble retention information gained in the pursuit of safe storage will, in turn, benefit future waste operations including salt-well pumping, waste transfers, and sluicing/retrieval.

Rassat, S.D.; Caley, S.M.; Bredt, P.R.; Gauglitz, P.A.; Rinehart, D.E.; Forbes, S.V.

1998-09-01T23:59:59.000Z

283

A theoretical study of the gas-phase ion pair SN2 reactions of lithium halide and methyl halide with inversion and retention mechanisms  

Science Journals Connector (OSTI)

Identity and non-identity ion pair SN2 reactions, LiX+CH3X, LiY+CH3X (Y, X=F, Cl, Br and I) were investigated using CCSD(T) calculations. Two possible reaction mechanisms, inversion and retention, were discussed. Introduction of lithium cation will significantly raise the inversion barriers and may lower the retention barriers. The analysis of barrier gaps between the two channels indicates that the retention mechanism is favorable for all of the reactions involving fluorine, in contrast to the anionic SN2 reactions at carbon where inversion reaction pathway is much more favorable for all halogens. The stabilization energies for dipoledipole complexes CH3X?LiY (Y=FI) are found to have a good correlation with the electronegativity of X. The CCSD(T) central barriers and overall barriers show good agreement with the predictions of Marcus equation and its modification, respectively. Further interesting feature of the non-identity ion pair SN2 reactions is a good correlation between inversion central barriers and the composite geometric looseness (%L).

Yan Xiong; Hua-jie Zhu; Yi Ren

2003-01-01T23:59:59.000Z

284

Matrix, Drug Testing for DOE Security Clearance- September 1, 2011  

Energy.gov (U.S. Department of Energy (DOE))

The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance

285

Unlocking enzyme synthesis of rare sugars to create drugs with...  

NLE Websites -- All DOE Office Websites (Extended Search)

this study is to dramatically improve the performance of enzymes that can be used by the pharmaceutical industry to synthesize drug precursors," said ORNL's Andrey Kovalevsky, the...

286

In silico modeling to predict drug-induced phospholipidosis  

SciTech Connect

Drug-induced phospholipidosis (DIPL) is a preclinical finding during pharmaceutical drug development that has implications on the course of drug development and regulatory safety review. A principal characteristic of drugs inducing DIPL is known to be a cationic amphiphilic structure. This provides evidence for a structure-based explanation and opportunity to analyze properties and structures of drugs with the histopathologic findings for DIPL. In previous work from the FDA, in silico quantitative structureactivity relationship (QSAR) modeling using machine learning approaches has shown promise with a large dataset of drugs but included unconfirmed data as well. In this study, we report the construction and validation of a battery of complementary in silico QSAR models using the FDA's updated database on phospholipidosis, new algorithms and predictive technologies, and in particular, we address high performance with a high-confidence dataset. The results of our modeling for DIPL include rigorous external validation tests showing 8081% concordance. Furthermore, the predictive performance characteristics include models with high sensitivity and specificity, in most cases above ? 80% leading to desired high negative and positive predictivity. These models are intended to be utilized for regulatory toxicology applied science needs in screening new drugs for DIPL. - Highlights: New in silico models for predicting drug-induced phospholipidosis (DIPL) are described. The training set data in the models is derived from the FDA's phospholipidosis database. We find excellent predictivity values of the models based on external validation. The models can support drug screening and regulatory decision-making on DIPL.

Choi, Sydney S.; Kim, Jae S.; Valerio, Luis G., E-mail: luis.valerio@fda.hhs.gov; Sadrieh, Nakissa

2013-06-01T23:59:59.000Z

287

Emergence of HIV-1 Drug Resistance During Antiretroviral Treatment  

E-Print Network (OSTI)

Bulletin of Mathematical Biology (2007). DOI 10.1007/s11538-007-9203-3. ORIGINAL ARTICLE. Emergence of HIV-1 Drug Resistance During Antiretroviral.

2007-08-22T23:59:59.000Z

288

Emergence of drug resistance - Department of Mathematics, Purdue ...  

E-Print Network (OSTI)

Emergence of drug resistance: implications for antiviral control of pandemic influenza. Murray E. Alexander. 1. , Christopher S. Bowman. 1. , Zhilan Feng. 2.

2007-08-22T23:59:59.000Z

289

Ethics and Drug-Free Certification Form  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

NEW EMPLOYEE ORIENTATION NEW EMPLOYEE ORIENTATION ETHICS BRIEFING CERTIFICATION OF ______________________________ (Print Name) I hereby certify that I have reviewed the New Employee Orientation information on the Standards of Ethical Conduct for Employees in the Executive Branch, 5 C.F. R. Part 2635, and the DOE 3792.3 Drug-Free Federal Workplace Testing Program. Further, I certify that I understand that all Department of Energy employees, other than Special Government Employees, must obtain prior written approval from their immediate supervisor and an ethics counselor prior to engaging in outside activities, regardless of whether those activities are compensated. I understand that this requirement includes approval of any activities in which I am engaged upon entering Federal

290

A Fluorescence Displacement Assay for Antidepressant Drug Discovery Based on Ligand-Conjugated Quantum Dots  

SciTech Connect

The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) protein plays a central role in terminating 5-HT neurotransmission and is the most important therapeutic target for the treatment of major depression and anxiety disorders. We report an innovative, versatile, and target-selective quantum dot (QD) labeling approach for SERT in single Xenopus oocytes that can be adopted as a drug-screening platform. Our labeling approach employs a custom-made, QD-tagged indoleamine derivative ligand, IDT318, that is structurally similar to 5-HT and accesses the primary binding site with enhanced human SERT selectivity. Incubating QD-labeled oocytes with paroxetine (Paxil), a high-affinity SERT-specific inhibitor, showed a concentration- and time-dependent decrease in QD fluorescence, demonstrating the utility of our approach for the identification of SERT modulators. Furthermore, with the development of ligands aimed at other pharmacologically relevant targets, our approach may potentially form the basis for a multitarget drug discovery platform.

Chang, Jerry [Vanderbilt University; Tomlinson, Ian [Oak Ridge National Laboratory (ORNL); Warnement, Michael [Vanderbilt University; Iwamoto, Hideki [Vanderbilt University

2011-01-01T23:59:59.000Z

291

Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance  

E-Print Network (OSTI)

Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance J. J. Westman-7045 USA Abstract A compartment model for the evolution of cancer subject to multiple chemotherapeutic agents is presented. The formulation accounts for the heterogeneous nature of cancer and drug resistance

Hanson, Floyd B.

292

A Drug Toxicity Death Involving Propylhexedrine and Mitragynine  

Science Journals Connector (OSTI)

......dismantled to extract the drug for abuse, propylhexedrine became the...the decedent's computer and internet usage history indicated he had...Online , and CEDIA for drugs of abuse. A full-scan (m/z 42550...propylhexedrine (Benzedrex ) abuse and sudden death. Am. J......

Justin M. Holler; Shawn P. Vorce; Pamela C. McDonough-Bender; Joseph Magluilo; Jr.; Carol J. Solomon; Barry Levine

2011-01-01T23:59:59.000Z

293

Polysaccharide-based aerogel microspheres for oral drug delivery  

Science Journals Connector (OSTI)

Abstract Polysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides and the enhanced drug loading capacity of dry aerogels. Aerogel microspheres from starch, pectin and alginate were loaded with ketoprofen (anti-inflammatory drug) and benzoic acid (used in the management of urea cycle disorders) via supercritical CO2-assisted adsorption. Amount of drug loaded depended on the aerogel matrix structure and composition and reached values up to 1.0נ10?3 and 1.7נ10?3g/m2 for ketoprofen and benzoic acid in starch microspheres. After impregnation, drugs were in the amorphous state in the aerogel microspheres. Release behavior was evaluated in different pH media (pH 1.2 and 6.8). Controlled drug release from pectin and alginate aerogel microspheres fitted Gallagher-Corrigan release model (R2>0.99 in both cases), with different relative contribution of erosion and diffusion mechanisms depending on the matrix composition. Release from starch aerogel microspheres was driven by dissolution, fitting the first-order kinetics due to the rigid starch aerogel structure, and showed different release rate constant (k1) depending on the drug (0.075 and 0.160min?1 for ketoprofen and benzoic acid, respectively). Overall, the results point out the possibilities of tuning drug loading and release by carefully choosing the polysaccharide used to prepare the aerogels.

C.A. Garca-Gonzlez; M. Jin; J. Gerth; C. Alvarez-Lorenzo; I. Smirnova

2014-01-01T23:59:59.000Z

294

Division of Human Resources Alcohol & Drug Testing (CDL)  

E-Print Network (OSTI)

Division of Human Resources Alcohol & Drug Testing (CDL) Summary of Program Responsibilities Employee Relations/Alcohol & Drug Testing (CDL) Questions: (813) 974-2970 Rev. 12/2008 · Report for duty for eight hours following an accident or until undergoing a post-accident test. · Report for duty or remain

Meyers, Steven D.

295

Division of Human Resources Alcohol & Drug Testing for  

E-Print Network (OSTI)

Division of Human Resources Alcohol & Drug Testing for Jobs Requiring CDL Employee Relations/Alcohol & Drug Testing (CDL) Questions: (813) 974-2970 Rev. 12/2008 · Report for duty or remain on duty requiring-accident testing is required, or until he/she undergoes a post-accident alcohol test, whichever occurs first

Meyers, Steven D.

296

Identification of new drug classification terms in textual resources  

Science Journals Connector (OSTI)

......F-score by 14% on the standard DrugBank corpus compared...obtained on the DrugBank standard (89% F-score) and on the Medline standard corpus (83% F-score...classifications. We plan to provide these...One very detailed review especially pinpointed...Evaluation of text mining in biology. In......

Corinna Kolrik; Martin Hofmann-Apitius; Marc Zimmermann; Juliane Fluck

2007-07-01T23:59:59.000Z

297

Drug-Free Federal Workplace Testing Implementation Program  

Directives, Delegations, and Requirements

The subject directive provides requirements and responsibilities for the implementation of a workplace program to test for the use of illegal drugs to facilitate the maintenance of a drug-free Federal workplace. In the course of the revision, the document number will change from DOE O 3792.3 to DOE O 343.1.

2012-12-06T23:59:59.000Z

298

ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY  

E-Print Network (OSTI)

are more related to the kind of cancer than to drug activity patterns. Dependency analysis using Bayesian1 11 ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY CLUSTERING AND BAYESIAN of data produced from up- to-date biological experimental processes needs appropriate data mining

299

Identifying novel drug indications through automated reasoning Authors and Affiliations  

E-Print Network (OSTI)

of these drugs have potential anti-cancer activities based on information on their targets and molecular discovery, text mining, automated reasoning Abstract Background With the large amount of pharmacological interaction types alone. A total of 507 drugs were found to have the potential to be used for cancer

Baral, Chitta

300

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
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they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

302

Plant Drug Analysis by Planar Chromatography  

Science Journals Connector (OSTI)

......during the time required to obtain a start of the elution process. Upon observing that migration was linear with time, it...Planar chromatography has become a modern technique with the commercialization of a large choice of adsorbents and the arrival of automated......

Nicole Galand; Jacques Pothier; Claude Viel

303

Fact Sheet on the Consequences of a Positive Drug Test | Department...  

Office of Environmental Management (EM)

Fact Sheet on the Consequences of a Positive Drug Test Fact Sheet on the Consequences of a Positive Drug Test FACT SHEET ON THE CONSEQUENCES OF A POSITIVE DRUG TEST The Secretary...

304

Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...EXPERIMENTAL THERAPEUTICS Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs...India We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs...histopathology, suggesting that the nanoparticle drug delivery system has potential...

Christine M. Johnson; Rajesh Pandey; Sadhna Sharma; G. K. Khuller; Randall J. Basaraba; Ian M. Orme; Anne J. Lenaerts

2005-10-01T23:59:59.000Z

305

Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine.  

Science Journals Connector (OSTI)

...that of placebo. Recovery of drug-resistant...for Microbiology Recovery of Drug-Resistant...Oklahoma 731063; and National Institute for Medical...documented the recovery of drug- resistant...respective institutional review boards ofthe participating...

F G Hayden; S J Sperber; R B Belshe; R D Clover; A J Hay; S Pyke

1991-09-01T23:59:59.000Z

306

An emerging platform for drug delivery: Aerogel based systems  

Science Journals Connector (OSTI)

Abstract Over the past few decades, advances in aerogel science have provoked an increasing interest for these materials in pharmaceutical sciences for drug delivery applications. Because of their high surface areas, high porosities and open pore structures which can be tuned and controlled by manipulation of synthesis conditions, nanostructured aerogels represent a promising class of materials for delivery of various drugs as well as enzymes and proteins. Along with biocompatible inorganic aerogels and biodegradable organic aerogels, more complex systems such as surface functionalized aerogels, composite aerogels and layered aerogels have also been under development and possess huge potential. Emphasis is given to the details of the aerogel synthesis and drug loading methods as well as the influence of synthesis parameters and loading methods on the adsorption and release of the drugs. Owing to their ability to increase the bioavailability of low solubility drugs, to improve both their stability and their release kinetics, there are an increasing number of research articles concerning aerogels in different drug delivery applications. This review presents an up to date overview of the advances in all kinds of aerogel based drug delivery systems which are currently under investigation.

Zeynep Ulker; Can Erkey

2014-01-01T23:59:59.000Z

307

Clinical, Laboratorial, and Urodynamic Findings of Prostatic Artery Embolization for the Treatment of Urinary Retention Related to Benign Prostatic Hyperplasia. A Prospective Single-Center Pilot Study  

SciTech Connect

PurposeThis study was designed to describe the clinical, laboratorial, and urodynamic findings of prostatic artery embolization (PAE) in patients with urinary retention due to benign prostatic hyperplasia (BPH).MethodsA prospective study of 11 patients with urinary retention due to BPH was conducted. Patients underwent physical examination, prostate specific antigen (PSA) measurement, transrectal ultrasound, and magnetic resonance imaging. International prostate symptom score (IPSS), quality of life (QoL), and urodynamic testing were used to assess the outcome before and after 1 year.ResultsClinical success was 91 % (10/11 patients) with a mean follow-up of 22.3 months (range, 12-41 months). At the first year follow-up, the mean IPSS score was 2.8 points (p = 0.04), mean QoL was 0.4 points (p = 0.001), mean PSA decreased from 10.1 to 4.3 ng/mL (p = 0.003), maximum urinary flow (Qmax) improved from 4.2 to 10.8 mL/sec (p = 0.009), and detrusor pressure (Pdet) decreased from 85.7 to 51.5 cm H{sub 2}O (p = 0.007). Before PAE, Bladder Outlet Obstruction Index (BOOI) showed values >40 in 100 % of patients. After PAE, 30 % of patients were >40 (obstructed), 40 % were between 20 and 40 (undetermined), and 30 % were <20 (unobstructed). Patients with a BOOI <20 had higher PSA values at 1-day after PAE.ConclusionsClinical and urodynamic parameters improved significantly after PAE in patients with acute urinary retention due to BPH. Total PSA at day 1 after PAE was higher in patients with unobstructed values in pressure flow studies.

Antunes, Alberto A. [University of Sao Paulo Medical School, Division of Urology (Brazil); Carnevale, Francisco C., E-mail: fcarnevale@uol.com.br; Motta Leal Filho, Joaquim M. da [University of Sao Paulo Medical School, Interventional Radiology Unit (Brazil); Yoshinaga, Eduardo M. [University of Sao Paulo Medical School, Division of Urology (Brazil); Cerri, Luciana M. O. [University of Sao Paulo Medical School, Ultrasound Unit (Brazil); Baroni, Ronaldo H. [University of Sao Paulo Medical School, Magnetic Resonance Unit (Brazil); Marcelino, Antonio S. Z. [University of Sao Paulo Medical School, Ultrasound Unit (Brazil); Cerri, Giovanni G. [University of Sao Paulo Medical School, Radiology Department (Brazil); Srougi, Miguel [University of Sao Paulo Medical School, Division of Urology (Brazil)

2013-08-01T23:59:59.000Z

308

Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis  

SciTech Connect

Isoniazid (INH) is a frontline antitubercular drug that inhibits the enoyl acyl carrier protein reductase InhA. Novel inhibitors of InhA that are not cross-resistant to INH represent a significant goal in antitubercular chemotherapy. The design, synthesis, and biological activity of a series of triclosan-based inhibitors is reported, including their promising efficacy against INH-resistant strains of M. tuberculosis. Triclosan has been previously shown to inhibit InhA, an essential enoyl acyl carrier protein reductase involved in mycolic acid biosynthesis, the inhibition of which leads to the lysis of Mycobacterium tuberculosis. Using a structure-based drug design approach, a series of 5-substituted triclosan derivatives was developed. Two groups of derivatives with alkyl and aryl substituents, respectively, were identified with dramatically enhanced potency against purified InhA. The most efficacious inhibitor displayed an IC{sub 50} value of 21 nM, which was 50-fold more potent than triclosan. X-ray crystal structures of InhA in complex with four triclosan derivatives revealed the structural basis for the inhibitory activity. Six selected triclosan derivatives were tested against isoniazid-sensitive and resistant strains of M. tuberculosis. Among those, the best inhibitor had an MIC value of 4.7 {mu}g mL{sup -1} (13 {mu}M), which represents a tenfold improvement over the bacteriocidal activity of triclosan. A subset of these triclosan analogues was more potent than isoniazid against two isoniazid-resistant M. tuberculosis strains, demonstrating the significant potential for structure-based design in the development of next generation antitubercular drugs.

Freundlich, Joel S.; Wang, Feng; Vilchze, Catherine; Gulten, Gulcin; Langley, Robert; Schiehser, Guy A.; Jacobus, David P.; Jacobs, Jr., William R.; Sacchettini, James C.; (Einstein); (TAM); (Jacobus)

2009-06-30T23:59:59.000Z

309

Our Current Approach to Drug Abuse -- Progress, Problems, Proposals  

Science Journals Connector (OSTI)

...treatment settings as appropriate. The intensity of a treatment is often independent of its setting. In addition, systematic research on outcomes is essential to improve the cost effectiveness of treatment and determine what works for whom and why. Such a system would be affordable, could be integrated... Most drug-abuse experts and historians agree that we are in the declining phase of a drug epidemic that began about 30 years ago. Still, drug abuse remains one of the nation's critical domestic problems, linked to crime, neglect of children, family ...

Kleber H.D.

1994-02-03T23:59:59.000Z

310

Sources of Regional Variation in Medicare Part D Drug Spending  

Science Journals Connector (OSTI)

...covariates demographic factors (age, sex, and race or ethnic group [black, white, Hispanic, or other]) and socioeconomic characteristics (individual-level Part D LIS status and ZIP Codelevel measures of median household income [by quintile] and proportion of the population living in poverty). An indicator... This analysis of 2008 Medicare data shows that regional variation in drug spending is driven primarily by the use of more expensive drugs (i.e., brand-name rather than generic drugs) in the highest-spending geographic areas.

Donohue J.M.; Morden N.E.; Gellad W.F.

2012-02-09T23:59:59.000Z

311

Time-Resolved  

NLE Websites -- All DOE Office Websites (Extended Search)

Time-Resolved Time-Resolved Time-Resolved Print Of the four fundamental parameters that we use to perceive the physical world (energy, momentum, position, and time) three correspond to the three broad categories of synchrotron experimental measurement techniques: spectroscopy (energy), scattering (momentum), and imaging (position). The fourth parameter-time-can in principle be applied to all the techniques. At the ALS, many experiments can be carried out in real time, with data being recorded from the same sample as it changes over time. Some time-resolved experiments take advantage of the pulsed nature of the ALS's synchrotron radiation, which, like a strobe light, can capture a series of "snapshots" of a process that, when viewed sequentially, show us how a given process evolves over time. Other experiments simply require two pulses: one to "pump" energy into the sample system and a second to probe the system's excited state.

312

E-Print Network 3.0 - age-related drug design Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

as improving symptom control... , London NW1 2BE. HIGHLIGHT Zebrafish as a drug screening platform ENABLING TECHNOLOGIES, PRODUCTS... of zebrafish to facilitate drug discovery....

313

E-Print Network 3.0 - antimalarial drug artemisinin Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

drug... artemisinin as the lead drug, using Partial Least Squares (PLS) regression. Methodology: All biological data... LQTA-QSAR ANALYSIS OF A SET OF ANTIMALARIAL COMPOUNDS...

314

E-Print Network 3.0 - antithyroid drug treatment Sample Search...  

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Science 57 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

315

E-Print Network 3.0 - acute cutaneous drug Sample Search Results  

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of Dundee Collection: Biology and Medicine 72 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: -inflammatory drugs are often...

316

E-Print Network 3.0 - alternative drug interaction Sample Search...  

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Mathematics 69 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

317

E-Print Network 3.0 - assessing drug treatment Sample Search...  

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Mathematics 28 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

318

E-Print Network 3.0 - avoiding drug development Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

diseases. To maximize drug viability and profit, one... development for use in the pharmaceutical industry in helping to determine viability of drugs... on the field of...

319

E-Print Network 3.0 - advanced drug design Sample Search Results  

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to this problem could be from rational drug design using Bioinformatics. The focus of the pharmaceutical industry... design. A successful and reliable drug design process could...

320

E-Print Network 3.0 - antipsychotic drug ykp1358 Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

and Idle, J.R. (1997). Antipsychotic drug-induced movement disorders... Fleischhacker, W.W., Meise, U., Gunther, V., and Kurz, M. (1994). Compliance with antipsychotic drug...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
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to obtain the most current and comprehensive results.


321

E-Print Network 3.0 - active drug delivery Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Drug Delivery, Bionanotechnology and Molecular Recognition, Departments... 78712, USA Recent advances in the discovery and delivery of drugs to cure chronic diseases are...

322

E-Print Network 3.0 - anticancer drug analysis Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

products, can have antibiotic, anticancer, anticholesterolemic... , and other activities that make them useful as drugs or drug leads for the treatment ... Source: New...

323

E-Print Network 3.0 - artery disease drugs Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Drug Plan Benefit Guide Revised 101510 Summary: artery disease or congestive heart failure) are eligible for the Value-Based Prescription Drug Plan... (Coronary Artery...

324

E-Print Network 3.0 - antirheumatic drug treatment Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

elderly: Pharmacy data as a tool for improvement Summary: Rochon PA, Gurwitz JH. Optimising drug treatment for elderly people: the prescribing cascade. BMJ 1997... for Drug...

325

E-Print Network 3.0 - amplifies stent-based drug Sample Search...  

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assessment for antiparasitic drug discovery Julie A. Frearson, Paul... G. Wyatt, Ian H. Gilbert and Alan H. Fairlamb Drug Discovery Unit, College of Life Sciences... , University...

326

E-Print Network 3.0 - antimalarial drug discovery Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

assessment for antiparasitic drug discovery Julie A. Frearson, Paul... G. Wyatt, Ian H. Gilbert and Alan H. Fairlamb Drug Discovery Unit, College of Life Sciences... , University...

327

E-Print Network 3.0 - antimicrobial drug discovery Sample Search...  

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assessment for antiparasitic drug discovery Julie A. Frearson, Paul... G. Wyatt, Ian H. Gilbert and Alan H. Fairlamb Drug Discovery Unit, College of Life Sciences... , University...

328

E-Print Network 3.0 - arsenic-based antineoplastic drugs Sample...  

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Summary: Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Health Care Settings" (http... Group 1 Carcinogens, Chemotherapy Waste and other Hazardous Drug...

329

E-Print Network 3.0 - antiparasitic drug nitazoxanide Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

330

E-Print Network 3.0 - antiinflammatory drug chemistry Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

drug chemistry Search Powered by Explorit Topic List Advanced Search Sample search results for: antiinflammatory drug chemistry Page: << < 1 2 3 4 5 > >> 1 Novel Anti-Inflammatory...

331

E-Print Network 3.0 - anticancer drug pump Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Therapeutic Delivery (2010) 1(2), 323334 Special FocuS: oncology Summary: drug efflux pumps, increasing drug metabolism, enhancing self-repairing ability or expressing altered......

332

Modeling within-host HIV-1 dynamics and the evolution of drug ...  

E-Print Network (OSTI)

Apr 19, 2007 ... of drug resistance: Trade-offs between viral enzyme function and drug susceptibility. Libin Ronga, Michael A. Gilchristb, Zhilan Fenga, Alan S.

2007-08-22T23:59:59.000Z

333

E-Print Network 3.0 - acquired drug resistance Sample Search...  

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drug resistance, especially if the focus of the analysis... 2010 pp. 905-918 AN ELEMENTARY APPROACH TO MODELING DRUG RESISTANCE IN CANCER Cristian Tomasetti... the problem of...

334

E-Print Network 3.0 - antiretroviral drug resistance Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

HIV in Summary: EDITORIAL REVIEW The antiretroviral rollout and drug-resistant HIV in Africa: insights from... , antiretroviral therapies, drug resistance, mathematical model,...

335

E-Print Network 3.0 - antiretroviral drug failure Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

HIV in Summary: EDITORIAL REVIEW The antiretroviral rollout and drug-resistant HIV in Africa: insights from... , antiretroviral therapies, drug resistance, mathematical model,...

336

E-Print Network 3.0 - antiretroviral drug exposure Sample Search...  

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HIV in Summary: EDITORIAL REVIEW The antiretroviral rollout and drug-resistant HIV in Africa: insights from... , antiretroviral therapies, drug resistance, mathematical model,...

337

FACT SHEET ON THE CONSEQUENCES OF A FAILED DRUG TEST  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

SHEET ON THE CONSEQUENCES OF A POSITIVE DRUG TEST SHEET ON THE CONSEQUENCES OF A POSITIVE DRUG TEST The Secretary has determined that applicants for, and holders of, a DOE "Q" or "L" access authorization (security clearance) will be in Testing Designated Positions (TDP) as specified in DOE Order 3792.3, Drug-Free Federal Workplace Testing Implementation Program, for federal employees, and Title 10 Code of Federal Regulations, Part 707, Workplace Substance Abuse Programs at DOE Sites, for contractor employees. Accordingly, individuals who are either in, or are selected for, a TDP are subject to applicant, random, and "for cause" testing. The information below summarizes the consequences of a positive test for drugs for each category of

338

Implementation Guidance, Drug Testing - December 3, 2007 | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Implementation Guidance, Drug Testing - December 3, 2007 Implementation Guidance, Drug Testing - December 3, 2007 Implementation Guidance, Drug Testing - December 3, 2007 December 3, 2007 Implementation guidance for applicants for, and holders of, a Department of Energy (DOE) Q or L access authorization (security clearance) selected for Testing Designated Positions (TDP) As established in his memorandum dated September 14, 2007, the Secretary has determined that applicants for, and holders of, a Department of Energy (DOE) Q or L access authorization (security clearance) will be in Testing Designated Positions (TDP) as specified in DOE Order 3792.3, Drug-Free Federal Workplace Testing Implementation Program, for Federal employees, and Title 10, Code of Federal Regulations, Part 707, Workplace Substance Abuse Programs at DOE Sites, for contractor employees. Accordingly,

339

Mechanism Based Anticancer Drugs that Degrade Sp Transcription Factors  

E-Print Network (OSTI)

Curcumin is the active component of tumeric, and this polyphenolic compound has been extensively investigated as an anticancer drug that modulates multiple pathways and genes. We demonstrated that curcumin inhibited 253JB-V and KU7 bladder cancer...

Chadalapaka, Gayathri

2013-03-14T23:59:59.000Z

340

Needle-free drug delivery using shock wave techniques  

E-Print Network (OSTI)

A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

Pavlov, Atanas (Atanas Ivanov)

2006-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Essays on prescription drug benefits in Medicare managed care  

E-Print Network (OSTI)

In this thesis, I estimate a structural demand model for prescription drug benefits by Medicare beneficiaries using data from the Medicare HMO program. I then use the utility parameter estimates to explore other questions ...

Hall, Anne Elizabeth, 1971-

2005-01-01T23:59:59.000Z

342

Abstract 4036: Drug repurposing to treat melanoma brain metastases  

Science Journals Connector (OSTI)

...4036: Drug repurposing to treat melanoma brain metastases Terje Sundstrom 1 Jobin K...of patients with metastatic melanoma, brain metastases remain an intractable problem...target single genes or pathways critical to brain metastasis formation. In this work we...

Terje Sundstrm; Jobin K. Varughese; Francisco Azuaje; Kjell Petersen; Clifford G. Tepper; Elizabeth Ingham; Lisa Even; Sarah Tam; Kai Ove Skaftnesmo; Morten Lund-Johansen; Rolf Bjerkvig; Katherine W. Ferrara; Frits A. Thorsen

2014-10-01T23:59:59.000Z

343

Revealing a Novel Mode of Action for an Osteoporosis Drug  

NLE Websites -- All DOE Office Websites (Extended Search)

is a U.S. Food and Drug Administration (FDA)-approved treatment for decreasing fracture risk in osteoporosis. While raloxifene is as effective at reducing fracture risk as...

344

Support for new US bill to safeguard country's drug supply  

Science Journals Connector (OSTI)

The proposed 'Drug Safety and Accountability Act' would establish quality standards for the FDA, pharmaceutical firms and their contractors, who are increasingly based overseas where safeguards may be lower than ...

2010-08-01T23:59:59.000Z

345

Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery  

E-Print Network (OSTI)

The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

Tan, Mei Chee

346

Pharmacokinetic and Pharmacodynamic Drug Interactions with Ethanol (Alcohol)  

Science Journals Connector (OSTI)

Ethanol (alcohol) is one of the most widely used legal drugs in the world. Ethanol is metabolized by alcohol dehydrogenase (ADH) ... lead to a clinically significant pharmacokinetic interaction with ethanol, whic...

Lingtak-Neander Chan; Gail D. Anderson

2014-12-01T23:59:59.000Z

347

Engineered microtissue platforms for modeling human pathophysiology and drug metabolism  

E-Print Network (OSTI)

Over 50% of all drug candidates entering clinical trials are abandoned due to insufficient efficacy or unexpected safety issues despite extensive pre-clinical testing. Liver metabolites that cause toxicity or other side ...

Li, Cheri Yingjie

2013-01-01T23:59:59.000Z

348

CHAPTER XV - TIME SERIES  

Science Journals Connector (OSTI)

Publisher Summary This chapter provides an overview of time series. A time series is a set of observations of a variable made at different points of time and arranged in chronological order, each observation representing the value of the variable either at a given moment or during the interval of time between this observation and the preceding one. In general, the observations forming a time-series as made at equidistant intervals of time are considered. The factors affecting time-series may be recurring or nonrecurring, or evolutionary, periodic, or random. The method of moving averages consists in determining the average value for a certain number of terms of a time series and taking this average as the trend normal value for the middle of the period covered in the calculation of the average, that is, the period extent of the moving average.

ISAAC PAENSON

1970-01-01T23:59:59.000Z

349

The Y-12 Times  

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good use Pages 4 and 5 The comings and goings during June Page 7 Y-12's new talent Ray Smith Donna Watson Bill Wilburn Lisa Xiques times times the B&W Technical Services Y-12,...

350

Towards engineering hormone-binding globulins as drug delivery agents  

E-Print Network (OSTI)

directly for destruction by the bodys immune system. There are currently three antibody-drug conjugates and 11 naked monoclonal antibodies approved by the Food and Drug Administration for the treatment of cancers [9, 10]. Another form of immunotherapy... efficacy in many cases [50]. Currently, the most common chemotherapeutic treatment for malignant metastatic prostate cancer is docetaxel, a mitotic poison [51]. In the next part of this proof-of-concept experiment, we sought to show that it is possible...

Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

2014-11-26T23:59:59.000Z

351

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure  

Science Journals Connector (OSTI)

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure ... The human brain is a uniquely complex organ, which has evolved a sophisticated protection system to prevent injury from external insults and toxins. ... Designing molecules that can overcome this protection system and achieve optimal concentration at the desired therapeutic target in the brain is a specific and major challenge for medicinal chemists working in CNS drug discovery. ...

Zoran Rankovic

2014-12-11T23:59:59.000Z

352

Noncommutative Two Time Physics  

E-Print Network (OSTI)

We present a classical formalism describing two-time physics with Abelian canonical gauge field backgrounds. The formalism can be used as a starting point for the construction of an interacting quantized two-time physics theory in a noncommutative soace-time.

W. Chagas-Filho

2006-04-03T23:59:59.000Z

353

Asia Times -Search Asia  

E-Print Network (OSTI)

Asia Times - Search Asia Times Advanced Search Southeast Asia Scapegoats for Indonesia's timber://www.atimes.com/atimes/Southeast_Asia/EI19Ae01.html (1 of 4)9/4/2007 3:01:50 PM Search #12;Asia Times - rather than on the nationwide band

354

Asia Times -Search Asia  

E-Print Network (OSTI)

Asia Times - Search Asia Times Advanced Search Southeast Asia Scapegoats for Indonesia's timber://www.atimes.com/atimes/Southeast_Asia/EI19Ae01.html (1 of 4)9/4/2007 12:55:07 PM Search #12;Asia Times - rather than on the nationwide band

355

Brave new interactions: performance-enhancing drugs for human-computer interaction  

Science Journals Connector (OSTI)

In sports, some athletes resort to performance enhancing drugs to gain an advantage. Similarly, people use pharmaceutical drugs to aid learning, dexterity, or concentration. We look at how such drugs could potentially be used to enhance interactions. ... Keywords: augmentation, boosting performance, enhanced interaction, performance-enhancing drugs

Henning Pohl

2014-04-01T23:59:59.000Z

356

A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products  

Science Journals Connector (OSTI)

Gillman, P. K. ( 2007) Tricyclic antidepressant pharmacology and therapeutic drug interactions updated Br. ... Gillman, P. K. ...

Anne Mai Wassermann; Eugen Lounkine; Laszlo Urban; Steven Whitebread; Shanni Chen; Kevin Hughes; Hongqiu Guo; Elena Kutlina; Alexander Fekete; Martin Klumpp; Meir Glick

2014-05-06T23:59:59.000Z

357

Trade Associations - The Chemical Alliance; Dyestuff Convention; American Drug Manufacturers Association.  

Science Journals Connector (OSTI)

Trade Associations - The Chemical Alliance; Dyestuff Convention; American Drug Manufacturers Association. ...

1918-01-01T23:59:59.000Z

358

Intrinsic Time Quantum Geometrodynamics  

E-Print Network (OSTI)

Quantum Geometrodynamics with intrinsic time development and momentric variables is presented. An underlying SU(3) group structure at each spatial point regulates the theory. The intrinsic time behavior of the theory is analyzed, together with its ground state and primordial quantum fluctuations. Cotton-York potential dominates at early times when the universe was small; the ground state naturally resolves Penrose's Weyl Curvature Hypothesis, and thermodynamic and gravitational `arrows of time' point in the same direction. Ricci scalar potential corresponding to Einstein's General Relativity emerges as a zero-point energy contribution. A new set of fundamental canonical commutation relations without Planck's constant emerges from the unification of Gravitation and Quantum Mechanics.

Eyo Eyo Ita III; Chopin Soo; Hoi-Lai Yu

2015-01-26T23:59:59.000Z

359

Time Series Analysis  

Science Journals Connector (OSTI)

Know how to apply simple methods for time series forecasting such as moving averages and the three levels of exponential smoothing.

Marc Goetschalckx

2011-01-01T23:59:59.000Z

360

Molecular Detection of Mutations Associated with First- and Second-Line Drug Resistance Compared with Conventional Drug Susceptibility Testing of Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...both first-line and second-line anti-TB drugs...reduction in the transmission of TB. Supplemental material for...acetyltransferase eis confers kanamycin...20004-20009. Supplemental material Supplemental...and second-line drug resistance...

Patricia J. Campbell; Glenn P. Morlock; R. David Sikes; Tracy L. Dalton; Beverly Metchock; Angela M. Starks; Delaina P. Hooks; Lauren S. Cowan; Bonnie B. Plikaytis; James E. Posey

2011-02-07T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Time functions as utilities  

E-Print Network (OSTI)

Every time function on spacetime gives a (continuous) total preordering of the spacetime events which respects the notion of causal precedence. The problem of the existence of a (semi-)time function on spacetime and the problem of recovering the causal structure starting from the set of time functions are studied. It is pointed out that these problems have an analog in the field of microeconomics known as utility theory. In a chronological spacetime the semi-time functions correspond to the utilities for the chronological relation, while in a K-causal (stably causal) spacetime the time functions correspond to the utilities for the K^+ relation (Seifert's relation). By exploiting this analogy, we are able to import some mathematical results, most notably Peleg's and Levin's theorems, to the spacetime framework. As a consequence, we prove that a K-causal (i.e. stably causal) spacetime admits a time function and that the time or temporal functions can be used to recover the K^+ (or Seifert) relation which indeed turns out to be the intersection of the time or temporal orderings. This result tells us in which circumstances it is possible to recover the chronological or causal relation starting from the set of time or temporal functions allowed by the spacetime. Moreover, it is proved that a chronological spacetime in which the closure of the causal relation is transitive (for instance a reflective spacetime) admits a semi-time function. Along the way a new proof avoiding smoothing techniques is given that the existence of a time function implies stable causality, and a new short proof of the equivalence between K-causality and stable causality is given which takes advantage of Levin's theorem and smoothing techniques.

E. Minguzzi

2009-09-04T23:59:59.000Z

362

Drug-Free Workplace Program UT-B Contracts Page 1 of 1  

E-Print Network (OSTI)

Drug-Free Workplace Program UT-B Contracts Sep 2012 Page 1 of 1 drug-free-workplace-ext-sep12 DRUG-FREE, the Seller and its subcontractors working on the project site must maintain a drug-free workplace program. (B) If the Seller is an out-of-state entity, the Company may upon request allow a drug-free workplace

Pennycook, Steve

363

Acceleration of Time Integration  

SciTech Connect

We outline our strategies for accelerating time integration for long-running simulations, such as those for global climate modeling. The strategies target the Cray XT systems at the National Center for Computational Sciences at Oak Ridge National Laboratory. Our strategies include fully implicit, parallel-in-time, and curvelet methods.

White III, James B [ORNL; Drake, John B [ORNL; Worley, Patrick H [ORNL; Archibald, Richard K [ORNL; Evans, Katherine J [ORNL; Kothe, Douglas B [ORNL

2007-01-01T23:59:59.000Z

364

Is Time Inhomogeneous ?  

E-Print Network (OSTI)

In this article, we discuss probability of inhomogeneous time in high or low energy scale of physics. Consequently, the possibility was investigated of using theories such as varying speed of light (VSL) and fractal mathematics to build a framework within which answers can be found to some of standard cosmological problems and physics theories on the basis of time non-homogeneity.

S. Davood Sadatian

2014-05-08T23:59:59.000Z

365

TIMELY WARNING CAMPUS ALERT  

E-Print Network (OSTI)

TIMELY WARNING CAMPUS ALERT 13 September 2007 This communication is prepared as part of the Timely of 1990. This federal law requires a general communication to the campus community of all crimes reported. Consider carefully whether your presence at or near the Lancaster Green Apartments while unaccompanied

Hardy, Christopher R.

366

Drug-SNPing: an integrated drug-based, protein interaction-based tagSNP-based pharmacogenomics platform for SNP genotyping  

Science Journals Connector (OSTI)

......Representative query results in the pipeline of Drug-SNPing. (A) Drug...results in the Drug-SNPing pipeline For the example of AHF (synonym...alignment and SNP identification pipeline. Bioinformatics (2009) 25...Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3......

Cheng-Hong Yang; Yu-Huei Cheng; Li-Yeh Chuang; Hsueh-Wei Chang

2013-03-15T23:59:59.000Z

367

Drugs affecting autonomic functions or the extrapyramidal system  

Science Journals Connector (OSTI)

Publisher Summary This chapter discusses the drugs that stimulate ?- and ?-adrenoceptors. These drugs include Adrenaline (epinephrine), ephedrine, and pseudoephrine. The effects of ephedrine and pseudoephedrine on the cardiovascular system are presented. Ephedrine and pseudoephedrine also have the potential for neuropsychiatric adverse events. The chapter discusses the adverse effects of levodopa, a drug that acts on dopamine receptors, on the nervous- and psychiatric-system. The adverse effects of dopamine receptor agonists are discussed on cardiovascular-, respiratory-, and nervous system. Most of the dopamine receptor agonists in current use are ergot derivatives, and these are known to cause serosal fibroinflammatory syndromes. The ergot alkaloids and related agents are discussed in the chapter. Despite the advent of the triptans, ergotamine is still used in the treatment of migraine, sometimes with predictable adverse effects.

Michael Schachter

2001-01-01T23:59:59.000Z

368

Finding of No Significant Impact/Construction of a New Office Building, Child-Care Facility, Parking Garage, and Storm-Water Retention Pond  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

NEW OFFICE BUILDING, CHILD-CARE FACILITY, PARKING GARAGE, NEW OFFICE BUILDING, CHILD-CARE FACILITY, PARKING GARAGE, AND STORM- WATER RETENTION POND AGENCY: U.S. Department of Energy (DOE) ACTION: Finding of No Significant Impact (FaNS I) SUMMARY: The DOE has prepared an Environmental Assessment (EA), DOE/EA-1444, to analyze the potential environmental consequences of a major facilities construction effort at the Morgantown, West Virginia, campus of the National Energy Technology Laboratory (NETL). Within the existing NETL site, the DOE would construct a new 3-story office building with 48,000 ft2 of usable office space, sufficient to accommodate approximately 135 employees. Existing parking space lost to the proposed new office building would be replaced by construction of a 3-level parking garage plus the addition of one or more new paved parking areas. Several

369

A theoretical study of the ion pair SN2 reaction between lithium isocyanates with methyl fluoride with inversion and retention mechanism  

Science Journals Connector (OSTI)

This paper is devoted to a detailed theoretical study of an ion pair SN2 reaction LiNCO+CH3F in the gas phase and in solution at the level of MP2(full)/6-31+G**//HF/6-31+G**. Two possible reaction mechanisms, inversion and retention, are discussed. There are eight possible reaction pathways. The inversion mechanism is more favorable no matter in the gas phase or in solution based on analyses of the transition structures. Methyl isocyanate should form preferentially in the gas phase and more stable methyl cyanate is the main product in solution. The retardation of the reaction in solvents was attributed to the difference in solvation in the separated reactants and in the transition state.

Hua-jie Zhu; Yi Ren; Jie Ren

2004-01-01T23:59:59.000Z

370

Overview of the US-Japan collaborative investigation on hydrogen isotope retention in neutron-irradiated and ion-damaged tungsten  

SciTech Connect

Plasma-facing components (PFCs) will be exposed to 14 MeV neutrons from deuterium-tritium (D-T) fusion reactions, and tungsten, a candidate PFC for the divertor in ITER, is expected to receive a neutron dose of 0.7 displacement per atom (dpa) by the end of operation in ITER. The effect of neutron-irradiation damage has been mainly simulated using high-energy ion bombardment. While this prior database of results is quite valuable for understanding the behavior of hydrogen isotopes in PFCs, it does not encompass the full range of effects that must be considered in a practical fusion environment due to short penetration depth, damage gradient, high damage rate, and high PKA energy spectrum of the ion bombardment. In addition, neutrons change the elemental composition via transmutations, and create a high radiation environment inside PFCs, which influence the behavior of hydrogen isotope in PFCs, suggesting the utilization of fission reactors is necessary for neutron irradiation. Therefore, the effort to correlate among high-energy ions, fission neutrons, and fusion neutrons is crucial for accurately estimating tritium retention under a neutron-irradiation environment. Under the framework of the US-Japan TITAN program, tungsten samples (99.99 at. % purity from A.L.M.T. Co.) were irradiated by neutron in the High Flux Isotope Reactor (HFIR), ORNL, at 50 and 300C to 0.025, 0.3, and 1.2 dpa, and the investigation of deuterium retention in neutron-irradiation was performed in the INL Tritium Plasma Experiment (TPE), the unique high-flux linear plasma facility that can handle tritium, beryllium and activated materials. This paper reports the recent results from the comparison of ion-damaged tungsten via various ion species (2.8 MeV Fe2+, 20 MeV W2+, and 700 keV H-) with that from neutron-irradiated tungsten to identify the similarities and differences among them.

Masashi Shimada; Y. Hatano; Y. Oya; T. Oda; M. Hara; G. Cao; M. Kobayashi; M. Sokolov; H. Watanabe; B. Tyburska; Y. Ueda; P. Calderoni

2011-09-01T23:59:59.000Z

371

EUROPIUM RETENTION ONTO CLAY MINERALS FROM 25 TO 150C: EXPERIMENTAL MEASUREMENTS, SPECTROSCOPIC FEATURES AND SORPTION MODELLING.  

E-Print Network (OSTI)

FEATURES AND SORPTION MODELLING. Tertre E.1,2 , Berger G.1 , Simoni E.3 , Castet S.1 , Giffaut E.2 , Loubet.Tertre@univ-lille1.fr Keywords: europium, sorption, clays, experimental, temperature, Time-Resolved Laser Fluorescence Spectroscopy (TRLFS) #12;2 Abstract The sorption of Eu (III) onto kaolinite and montmorillonite

Paris-Sud XI, Université de

372

Kairoscope : coordinating time socially  

E-Print Network (OSTI)

If everyone says time is relative, why is it still so rigidly defined? There have been many attempts to address the issue of coordinating schedules, but each of these attempts runs into an issue of rigidity: in order to ...

Martin, Reed Eric

2010-01-01T23:59:59.000Z

373

California's Shaking Next Time  

Science Journals Connector (OSTI)

...ground along a road. Only 10 hours...expect that the design expertise lavished...architectural designs ofthat time as...the left. The pipelines, rail lines, and aqueducts crossing the San Andreas...block mountain roads. Forty-six...

RICHARD A. KERR

1982-01-22T23:59:59.000Z

374

Physicochemical investigations of a drug delivery oscillator  

E-Print Network (OSTI)

75 mM Glucose/10 % MAA /kmarble= 0.00199 s-1 I = 50 mM (50 mM NaCl+0 mM CaCl2) I = 95 mM (50 mM NaCl + 15 mM CaCl2) I = 155 mM (50 mM NaCl+ 35 mM CaCl2) I = 155 mM (155 mM NaCl+ 0 mM CaCl2) p H Device Membrane - Hydrogel N...4.6 4.7 4.8 4.9 5 5.1 5.2 5.3 5.4 0 0.2 0.4 0.6 0.8 1 Time (Days) p H Glucose Gluconic acid Gluconic acid Gluconate- + H+ H+ + CaCO3 Ca 2+ + HCO3- H+ + HCO3- H2CO3 pKa = 6.37 H2CO3 CO2 ? + H2O pKa = 3.6 ? Buffer Build-Up Affects...

Bhalla, A. S.; Siegel, R. A.

2006-10-27T23:59:59.000Z

375

Stress, Risk Taking, Alcohol/Drugs, and Parents as Partners  

E-Print Network (OSTI)

college � Particular Interests Alcohol and other drug abuse Prescription stimulant abuse Marijuana, bronchitis, Strep throat 9.0% Internet use/computer games 17.3% Finances 8.9% Depression 16.3% Alcohol use 8 other students are doing #12;Parents Still Matter! � In adolescents and young adults, shift

Stowell, Michael

376

A Drug Toxicity Death Involving Propylhexedrine and Mitragynine  

Science Journals Connector (OSTI)

......toxicity urine Substance Abuse Detection methods Substance-Related...Tandem Mass Spectrometry Young Adult A death involving abuse of propylhexedrine and...decedent's computer and internet usage history indicated...and CEDIA for drugs of abuse. A full-scan (m......

Justin M. Holler; Shawn P. Vorce; Pamela C. McDonough-Bender; Joseph Magluilo; Jr.; Carol J. Solomon; Barry Levine

2011-01-01T23:59:59.000Z

377

Pharmacokinetics of tobramycin and gentamicin in abusers of intravenous drugs.  

Science Journals Connector (OSTI)

...Median duration (days) of 7 (1-100) 5 (1-100) 26 (5-60) symptoms before admis- sion (range) Reported drug usec Heroin 9 (50) 4 (33) 5 (83) Pentazocine-pyribenzamine 8 (44) 5 (42) 3 (50) ("T's and blues") Meperidine 5...

C H King; R J Creger; J J Ellner

1985-03-01T23:59:59.000Z

378

Optimization and Simulation in Drug Development -Review and Analysis  

E-Print Network (OSTI)

in the context of the pharmaceutical industry. 4 #12; 1 Introduction The presen-Eriksen and Jens Clausen Keywords: Pharmaceutical R&D, Drug Discovery and Development, Modelling and sim- ulation, Clinical Trial Simulation Portfolio optimization 1 #12; Contents 1 Introduction 5 2 Pharmaceutical products

379

Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...review-article Minireview Energy Metabolism and Drug Efflux...of ATP. This suggests that energy metabolism and ATP production...treatment of XDR-TB patients in Argentina and is currently being used...bacterial targets involved in energy metabolism. These combinations...

Philippa A. Black; Robin M. Warren; Gail E. Louw; Paul D. van Helden; Thomas C. Victor; Bavesh D. Kana

2014-03-10T23:59:59.000Z

380

Cryogenic Chiral Chromatography for Rapid Resolution of Drug Candidates  

Science Journals Connector (OSTI)

Cryogenic Chiral Chromatography for Rapid Resolution of Drug Candidates ... The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to ?25 C. ... Although none of the studied compounds could be completely separated at room temperature, a baseline separation was achieved at cryogenic temperatures. ...

Martti Alkio; Olli Aaltonen; Harri Setl

2005-09-13T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Kelly Scientific Resources Kelly Scientific Resources yy BIOTECHNOLOGY DRUG &  

E-Print Network (OSTI)

Kelly Scientific Resources Kelly Scientific Resources yy BIOTECHNOLOGY DRUG & PHARMACEUTICAL · What Kelly Scientific Resources or staffing agencies are and how they work?they work? · How to work Role: ­ Northern California Recruiting and Business efforts for Kelly Scientific Resources ­ Promote

Puglisi, Joseph

382

Protein Dynamics in Drug Combinations: a Linear Superposition  

E-Print Network (OSTI)

on cells and organisms. Little is known about how drugs affect protein dynamics that deter- mine or activity) of one of the cells proteins (Figure 1). The goal is to guide the cell from a ``sick state'' to a ``healthy state'' in a rational manner (or, in the case of cancer, from a living cancer cell to a dead

383

Molecular Fragment Mining for Drug Discovery Christian Borgelt1  

E-Print Network (OSTI)

Molecular Fragment Mining for Drug Discovery Christian Borgelt1 , Michael R. Berthold2 , and David will be active or inactive, so that future chemical tests can be focused on the most promis- ing candidates that discriminate between active and inactive molecules. In this paper we review this approach as well as two

Berthold, Michael R.

384

A PARYLENE BELLOWS ELECTROCHEMICAL ACTUATOR FOR INTRAOCULAR DRUG DELIVERY  

E-Print Network (OSTI)

Implant INTRODUCTION Water electrolysis using coplanar microelectrodes offers a promising pumping with the contents of the drug reservoir. Electrolysis-induced gas generation (phase change of water into hydrogen) water and then joined together (Figure 2). Electrolysis pumping is selected over other actuation methods

Meng, Ellis

385

Application of Ion Chromatography in Pharmaceutical and Drug Analysis  

Science Journals Connector (OSTI)

......provided. Citrate, acetate Bio-Rad HPX-87H...conductivity Measured this drug synthesis 52 (150 4.1 mm...sulfate. Including lithium, sodium, ammonium...hydrogen carbonate mixture synthesis byproduct. Method validation...9 to 100.3% or acetate. Pooled data, 99 exclusion......

Dennis Jenke

2011-08-01T23:59:59.000Z

386

Potentially Inappropriate Drug Prescribing and Associated Factors in Nursing Homes  

Science Journals Connector (OSTI)

AbstractImportance Polymedication is frequent in nursing home (NH) residents. This increases the risk of potentially inappropriate drug prescribing (PIDP), which can lead to adverse drug events, such as falls and hospitalization. Objective To identify PIDP in NH residents and to investigate subject-related and NH structural and organizational factors associated with PIDP. Design Cross-sectional study. Setting A total of 175 \\{NHs\\} in Midi-Pyrnes region, South-Western France. Participants A total of 974 subjects randomly selected from the 6275 NH residents participating in the IQUARE study. Exposure Patients with PIDP. Main Outcomes and Measures PIDP was the main outcome measure. It was defined using a specific indicator, based on the Summary of Product Characteristics, on the Laroche list, and on residents' clinical data. PIDP was defined as the presence of at least 1 of the following criteria: (1) drug with an unfavorable benefit-to-risk ratio; (2) drug with questionable efficacy according to the Laroche list; (3) absolute contraindication; (4) significant drug-drug interaction. Associated factors were identified by using multivariable logistic regression models. Results Among the 974 residents included, 71% had PIDP. PIDP was more frequent in patients without dementia, with several comorbidities and taking multiple medications. In the multivariable analysis, age (odds ratio [OR] 1.02; 95% confidence interval [CI] 1.011.03) and Charlson Comorbidity Index (CCI; P=.003, CCI= 1 versus 0: OR1/0 1.22; 95% CI 0.851.74, CCI ? 2 versus 0: OR2/0 1.72; 95% CI 1.232.41) were associated with an increased likelihood of PIDP. By contrast, dementia was associated with a lower likelihood of PIDP (OR 0.70; 95% CI 0.530.94). Among NH structural and organizational characteristics, the access to psychiatric advice and/or to hospitalization in a psychiatric unit (OR 1.36; 95% CI 1.021.82) and the presence of a reevaluation of drug prescriptions (OR 1.45; 95% CI 1.071.96) were associated with an increased likelihood of PIDP. Conclusions and Relevance Our work suggests that some NH characteristics are associated with an increased likelihood of PIDP. Gaining a better understanding of the factors influencing PIDP, especially structural andorganizational NH factors, can help to determine the interventions that should be implemented.

Charlne Cool; Philippe Cestac; Charlotte Laborde; Ccile Lebaudy; Laure Rouch; Benoit Lepage; Bruno Vellas; Philipe de Souto Barreto; Yves Rolland; Maryse Lapeyre-Mestre

2014-01-01T23:59:59.000Z

387

Validation of LCTOF-MS Screening for Drugs, Metabolites, and Collateral Compounds in Forensic Toxicology Specimens  

Science Journals Connector (OSTI)

......quantitation of multiclass drugs of abuse and pharmaceuticals in hair...pharmaceuticals and drugs of abuse in hair using UPLC-TOF-MS...toxicology of emerging drugs of abuse. Therapeutic Drug Monitoring...police investigation of a Danish Internet company. Drug Testing and Analysis......

Fessessework Guale; Shahriar Shahreza; Jeffrey P. Walterscheid; Hsin-Hung Chen; Crystal Arndt; Anna T. Kelly; Ashraf Mozayani

2013-01-01T23:59:59.000Z

388

Abstract CN01-02: canSAR: An integrated cancer drug discovery informatics platform allowing systematic target evaluation.  

Science Journals Connector (OSTI)

...drugs, due to their chemical composition, are unsuitable...nanogel drug delivery platform that can (i) encapsulate...nanogels: a versatile platform for drug delivery to...drugs, due to their chemical composition, are unsuitable...nanogel drug delivery platform that can (i) encapsulate...

Bissan Al-Lazikani; Mishal Patel; Krishna Bulusu; and Mark Halling-Brown

2011-11-01T23:59:59.000Z

389

New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis  

E-Print Network (OSTI)

We report results of an experimental study, complemented by detailed statistical analysis of the experimental data, on the development of a more effective control method of drug delivery using a pH sensitive acrylic polymer. New copolymers based on acrylic acid and fatty acid are constructed from dodecyl castor oil and a tercopolymer based on methyl methacrylate, acrylic acid and acryl amide were prepared using this new approach. Water swelling characteristics of fatty acid, acrylic acid copolymer and tercopolymer respectively in acid and alkali solutions have been studied by a step-change method. The antibiotic drug cephalosporin and paracetamol have also been incorporated into the polymer blend through dissolution with the release of the antibiotic drug being evaluated in bacterial stain media and buffer solution. Our results show that the rate of release of paracetamol getss affected by the pH factor and also by the nature of polymer blend. Our experimental data have later been statistically analyzed to quantify the precise nature of polymer decay rates on the pH density of the relevant polymer solvents. The time evolution of the polymer decay rates indicate a marked transition from a linear to a strictly non-linear regime depending on the whether the chosen sample is a general copolymer (linear) or a tercopolymer (non-linear). Non-linear data extrapolation techniques have been used to make probabilistic predictions about the variation in weight percentages of retained polymers at all future times, thereby quantifying the degree of efficacy of the new method of drug delivery.

N. Panja; A. K. Chattopadhyay

2014-12-05T23:59:59.000Z

390

Detecting drug-induced prolongation of the QRS complex: New insights for cardiac safety assessment  

SciTech Connect

Background: Drugs slowing the conduction of the cardiac action potential and prolonging QRS complex duration by blocking the sodium current (I{sub Na}) may carry pro-arrhythmic risks. Due to the frequency-dependent block of I{sub Na}, this study assesses whether activity-related spontaneous increases in heart rate (HR) occurring during standard dog telemetry studies can be used to optimise the detection of class I antiarrhythmic-induced QRS prolongation. Methods: Telemetered dogs were orally dosed with quinidine (class Ia), mexiletine (class Ib) or flecainide (class Ic). QRS duration was determined standardly (5 beats averaged at rest) but also prior to and at the plateau of each acute increase in HR (3 beats averaged at steady state), and averaged over 1 h period from 1 h pre-dose to 5 h post-dose. Results: Compared to time-matched vehicle, at rest, only quinidine and flecainide induced increases in QRS duration (E{sub max} 13% and 20% respectively, P < 0.010.001) whereas mexiletine had no effect. Importantly, the increase in QRS duration was enhanced at peak HR with an additional effect of + 0.7 0.5 ms (quinidine, NS), + 1.8 0.8 ms (mexiletine, P < 0.05) and + 2.8 0.8 ms (flecainide, P < 0.01) (calculated as QRS at basal HR-QRS at high HR). Conclusion: Electrocardiogram recordings during elevated HR, not considered during routine analysis optimised for detecting QT prolongation, can be used to sensitise the detection of QRS prolongation. This could prove useful when borderline QRS effects are detected. Analysing during acute increases in HR could also be useful for detecting drug-induced effects on other aspects of cardiac function. -- Highlights: ? We aimed to improve detection of drug-induced QRS prolongation in safety screening. ? We used telemetered dogs to test class I antiarrhythmics at low and high heart rate. ? At low heart rate only quinidine and flecainide induced an increase in QRS duration. ? At high heart rate the effects of two out of three antiarrhythmics were enhanced. ? Detection of a drug-induced prolongation of QRS was improved at high heart rate.

Cros, C., E-mail: caroline.cros@hotmail.co.uk [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Skinner, M., E-mail: Matthew.Skinner@astrazeneca.com [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Moors, J. [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom)] [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Lainee, P. [Sanofi-Aventis R and D, 371, rue du Pr Joseph Blayac, 34184 Montpellier Cedex 04 (France)] [Sanofi-Aventis R and D, 371, rue du Pr Joseph Blayac, 34184 Montpellier Cedex 04 (France); Valentin, J.P. [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom)] [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom)

2012-12-01T23:59:59.000Z

391

Probabilistic timed behavior trees  

Science Journals Connector (OSTI)

The Behavior Tree notation has been developed as a method for systematically and traceably capturing user requirements. In this paper we extend the notation with probabilistic behaviour, so that reliability, performance, and other dependability properties ... Keywords: behavior trees, model checking, probabilities, timed automata

Robert Colvin; Lars Grunske; Kirsten Winter

2007-07-01T23:59:59.000Z

392

Time reversal communication system  

DOE Patents (OSTI)

A system of transmitting a signal through a channel medium comprises digitizing the signal, time-reversing the digitized signal, and transmitting the signal through the channel medium. The channel medium may be air, earth, water, tissue, metal, and/or non-metal.

Candy, James V. (Danville, CA); Meyer, Alan W. (Danville, CA)

2008-12-02T23:59:59.000Z

393

Time-Encoded Imagers.  

SciTech Connect

This report provides a short overview of the DNN R&D funded project, Time-Encoded Imagers. The project began in FY11 and concluded in FY14. The Project Description below provides the overall motivation and objectives for the project as well as a summary of programmatic direction. It is followed by a short description of each task and the resulting deliverables.

Marleau, Peter; Brubaker, Erik

2014-11-01T23:59:59.000Z

394

Genepool Time Heatmaps  

NLE Websites -- All DOE Office Websites (Extended Search)

Genepool Time Heatmaps Genepool Time Heatmaps Heatmap of Time and Slots Requested vs Time Waited (in hours) | Queue: All | Last 7 Days Time Requested Slots 1wk Job Count Longest Wait 1 23.0 (233) 0.37 (1819) 27.54 (49888) 5.85 (124593) 1.23 (39835) 0.34 (732) 0 0.4 (224) 0.02 (1) 217325 538.96 2 0 0.01 (19) 2.54 (78) 0.2 (140) 0.99 (2683) 0 0 0 0 2920 9.1 4 0.08 (1) 0 2.82 (141) 0.36 (143) 1.07 (12) 0.06 (5) 0.01 (5) 0.06 (1) 1.3 (5) 313 20.48 6 0.01 (2) 0 0.09 (32) 0.07 (1) 0 0 0 0 0 35 1.22 8 0.04 (24) 4.32 (7423) 5.31 (1999) 0.53 (316) 13.14 (2486) 0.01 (2) 1.21 (88) 1.3 (34) 8.33 (68) 12440 46.16 10 0 0 0 0 0 0 0 8.56 (1) 0 1 8.56 16 0 0 0 0.03 (1) 0 0 0 0 0 1 0.03 24 0 0 0 0 0 0 0 0 0.01 (1) 1 0.01 32 0 0 0 0.04 (14) 0 0 0 0.01 (6) 0 20 0.26

395

E-Print Network 3.0 - anti-cancer drug design Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: anti-cancer drug design Page: << < 1 2 3 4 5 > >> 1 Biology-based Drug Design Summary: - New...

396

Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport  

E-Print Network (OSTI)

Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

Tang, Hua, 1972-

2002-01-01T23:59:59.000Z

397

Development of lymphatic drug delivery platforms for the treatment of carcinomas  

E-Print Network (OSTI)

, and evaluated in preclinical rodent models. The route of drug administration along with the controlled release of the drug from the platforms, both play an important role in improving the biopharmaceutical properties of these conjugates. This is demonstrated...

Cai, Shuang

2011-05-31T23:59:59.000Z

398

Two Fatal Intoxications with the New Designer Drug Methedrone (4-Methoxymethcathinone)  

Science Journals Connector (OSTI)

......poisoning Substance Abuse Detection Tandem Mass Spectrometry Young Adult We report two...available through the internet. Even though gov...substances have hit the internet drug market as a...medications and drugs of abuse were performed in......

Maria Wikstrm; Gunilla Thelander; Ingrid Nystrm; Robert Kronstrand

2010-01-01T23:59:59.000Z

399

An Evaluation of Rapid Point-of-Collection Oral Fluid Drug-Testing Devices  

Science Journals Connector (OSTI)

......Street Drugs analysis Substance Abuse Detection instrumentation methods...ofincreasedtesting fordrugs of abuse intheworkplace,in treatment...matrix for detecting drugs of abuse (2-6). Mixed saliva,or...literature, researched the Internet, and contacteda variety of......

J. Michael Walsh; Ron Flegel; Dennis J. Crouch; Leo Cangianelli; Jakub Baudys

2003-10-01T23:59:59.000Z

400

Computational analysis of biochemical networks for drug target identification and therapeutic intervention design  

E-Print Network (OSTI)

Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear ...

Paudel, Nirmala

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Magnetically-triggered Nanocomposite Membranes: a Versatile Platform for Triggered Drug Release  

E-Print Network (OSTI)

Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field. The dose of drug delivered can be tuned by engineering the phase transition temperature of the nanogel, the loading of nanogels in the membrane, and the membrane thickness, allowing for the delivery of drugs over several orders of magnitude of release rates. The zero-order kinetics of drug release through the membranes permit drug doses from a specific device to be tuned according to the duration of the magnetic field. Drugs over a broad range of molecular weights (500-40,000 Da) can be delivered by the same membrane device. Membrane-to-membrane and cycle-to-cycle reproducibility is demonstrated, suggesting the general utility of these membranes for drug delivery.

Todd Hoare; Brian P. Timko; Jesus Santamaria; Gerardo F. Goya; Silvia Irusta; Debora Lin; Samantha Lau; Robert Langer; Daniel S. Kohane

2011-06-27T23:59:59.000Z

402

Assessing the impact of tumor evolution on oncology drug development and commercialization  

E-Print Network (OSTI)

This thesis investigates the commercial viability of developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs ...

Sterk, Joseph P. (Sterk, Joseph Phillip)

2011-01-01T23:59:59.000Z

403

The Drug Evaluation and Classification Program in the state of Texas: a validation study  

E-Print Network (OSTI)

drug categories were most frequently called by DREs who evaluated subjects: depressants, 182; cannabis, 142; narcotic analgesics, 83; stimulants, 62; PCP, 18; inhalants, 4; and hallucinogens, 1. To determine which drug categories were most frequently...

Walden, Troy Duane

2005-08-29T23:59:59.000Z

404

E-Print Network 3.0 - antihistaminic drugs modify Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

amount of drug in GI tract y(t) amount of drug... 0.1386 per hour and A 1. Use Matlab to graph x and y. Estimate the highest level of antihistamine... for k1 0.06931,...

405

E-Print Network 3.0 - albumin impaired drug-binding Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

acid concentrations and variants on Summary: such as quinidine to ORM1 S and* 5 * ORM1 F1 ( , ). drug-binding studies are warranted to determine the possible... . Drug Metab...

406

Changes in the characteristics of approved New Drug Applications for antihypertensives  

E-Print Network (OSTI)

In this thesis, the control of hypertension provides the backdrop for my effort to investigate how clinical trial design has evolved for antihypertensive drug submissions reviewed and approved by the Food and Drug ...

MacNeil, John Simon Howe

2007-01-01T23:59:59.000Z

407

The dual-piston jet injector and the viability of drug delivery  

E-Print Network (OSTI)

Drug delivery through jet-injection opens the doors to very rapid drug dispersion by eliminating the need for needle sterilization. With this comes the need for a continuous flow of fluids from a large reservoir, currently ...

Cunningham, Daniel (Daniel P.)

2007-01-01T23:59:59.000Z

408

Medical data mining : improving information accessibility using online patient drug reviews  

E-Print Network (OSTI)

We address the problem of information accessibility for patients concerned about, pharmaceutical drug side effects and experiences. We create a new corpus of online patient-provided drug reviews and present our initial ...

Li, Yueyang Alice

2011-01-01T23:59:59.000Z

409

E-Print Network 3.0 - anticancer drugs infusion Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

drugs infusion Search Powered by Explorit Topic List Advanced Search Sample search results for: anticancer drugs infusion Page: << < 1 2 3 4 5 > >> 1 Friday, April 29, 2011 UNM...

410

E-Print Network 3.0 - activation inhibits drug-resistant Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

as a function of: (i) the transmissibility (i.e., fitness) of the drug-resistant... that transmission of drug-resistant strains in Botswana could increase to ,15% by 2009 if...

411

STOPPING TIMES IN QUANTUM MECHANICS  

E-Print Network (OSTI)

(Stinespring, Kraus). 3". Time-dependant case General time evolution of an open quantum sys- tem = (Pt)t0

Attal, Stéphane

412

Rick Grush Brain time and phenomenological time (draft) Page 1/37 Brain time and phenomenological time  

E-Print Network (OSTI)

Rick Grush Brain time and phenomenological time (draft) Page 1/37 Brain time and phenomenological "forthwith" in a common structure. - Edmund Husserl, Phenomenology of Inner Time Consciousness1 1 time and phenomenological time (draft) Page 2/37 information-processing structure that accounts

Grush, Rick

413

Nanomedicine for Cancer: Lipid-Based Nanostructures for Drug Delivery and Monitoring  

Science Journals Connector (OSTI)

Nanomedicine for Cancer: Lipid-Based Nanostructures for Drug Delivery and Monitoring ... Lipid-Based Nanomedicines for Cancer ...

Yoshihisa Namiki; Teruaki Fuchigami; Norio Tada; Ryo Kawamura; Satoshi Matsunuma; Yoshitaka Kitamoto; Masaru Nakagawa

2011-07-26T23:59:59.000Z

414

ESPC Success Story- Food and Drug Administration (FDA) White Oak Campus  

Energy.gov (U.S. Department of Energy (DOE))

FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus.

415

E-Print Network 3.0 - antimalarial drug resistance Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

disease pathophysiology, drug resistance... and antimalarial resistance, and optimising treatments for pregnant women melioidosis - conducting clinical... treatments,...

416

E-Print Network 3.0 - antiretroviral drug costs Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Summary: pediatric antiretroviral drug formulations, lack of personnel with health care expertise in treatment... formulations and simplified ARV regimens optimized...

417

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics  

Science Journals Connector (OSTI)

...transport of molecular drugs in cancer theranostics 10.1073/pnas.1220817110 Guizhi...drug transport platform for cancer theranostics. Although chemotherapeutic drugs are widely used in...promising TDT platform for targeted cancer theranostics. Results and Discussion Construction...

Guizhi Zhu; Jing Zheng; Erqun Song; Michael Donovan; Kejing Zhang; Chen Liu; Weihong Tan

2013-01-01T23:59:59.000Z

418

Tevatron injection timing  

SciTech Connect

Bunched beam transfer from one accelerator to another requires coordination and synchronization of many ramped devices. During collider operation timing issues are more complicated since one has to switch from proton injection devices to antiproton injection devices. Proton and antiproton transfers are clearly distinct sequences since protons and antiprotons circulate in opposite directions in the Main Ring (MR) and in the Tevatron. The time bumps are different, the kicker firing delays are different, the kickers and lambertson magnets are different, etc. Antiprotons are too precious to be used for tuning purposes, therefore protons are transferred from the Tevatron back into the Main Ring, tracing the path of antiprotons backwards. This tuning operation is called ``reverse injection.`` Previously, the reverse injection was handled in one supercycle. One batch of uncoalesced bunches was injected into the Tevatron and ejected after 40 seconds. Then the orbit closure was performed in the MR. In the new scheme the lambertson magnets have to be moved and separator polarities have to be switched, activities that cannot be completed in one supercycle. Therefore, the reverse injection sequence was changed. This involved the redefinition of TVBS clock event $D8 as MRBS $D8 thus making it possible to inject 6 proton batches (or coalesced bunches) and eject them one at a time on command, performing orbit closure each time in the MR. Injection devices are clock event driven. The TCLK is used as the reference clock. Certain TCLK events are triggered by the MR beam synchronized clock (MRBS) events. Some delays are measured in terms of MRBS ticks and MR revolutions. See Appendix A for a brief description of the beam synchronized clocks.

Saritepe, S.; Annala, G.

1993-06-01T23:59:59.000Z

419

Multiple-Drug Toxicity Caused by the Coadministration of 4-Methylmethcathinone (Mephedrone) and Heroin  

Science Journals Connector (OSTI)

......of Results Substance Abuse Detection Young Adult An accidental death...found for sale on the internet as a re- search chemical...be discovered through internet drug user forums. Multiple-DrugToxicity...considered a rare drug of abuse. However, in July 2009......

Amber J. Dickson; Shawn P. Vorce; Barry Levine; Marilyn R. Past

2010-04-01T23:59:59.000Z

420

Multiple Fatalities Involving a New Designer Drug: Para-Methyl-4-Methylaminorex  

Science Journals Connector (OSTI)

......so-called head shops or over the internet and are often described as not...submitted in a number of drug abuse deaths; some of which were...Aks S.E. Emerging drugs of abuse. Emergency Medicine Clinics...Future synthetic drugs of abuse. (1988) Castonguay, R......

S. Cosbey; S. Kirk; M. McNaul; L. Peters; B. Prentice; A. Quinn; S.P. Elliott; S.D. Brandt; R.P. Archer

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Two Fatal Intoxications with the New Designer Drug Methedrone (4-Methoxymethcathinone)  

Science Journals Connector (OSTI)

......chemistry poisoning Substance Abuse Detection Tandem Mass...available through the internet. Even though gov- ernments...substances have hit the internet drug market as a "safe...medications and drugs of abuse were performed in femoral...screened for drugs of abuse using an liquid chromatography......

Maria Wikstrm; Gunilla Thelander; Ingrid Nystrm; Robert Kronstrand

2010-01-01T23:59:59.000Z

422

Mathematical modelling of drug transport in tumour multicell spheroids and monolayer cultures  

E-Print Network (OSTI)

an enhanced survival rate in multicell spheroids compared to monolayer cultures, consistent with experimental observations, and indicate that the key factor determining this is drug penetration. An analysis of the large penetration of effective quantities of drugs deep into the tumour, due to drug transport being mainly

423

CABM Symposium Applications of NMR to structure-based drug design in structural  

E-Print Network (OSTI)

CABM Symposium Applications of NMR to structure-based drug design in structural genomics Robert, structure-based drug design, structural genomics Abstract Structural genomics is poised to have a tremendous design in the era of structural genomics. Introduction Structure-based drug design has established itself

Powers, Robert

424

A Key Target for Diabetes Drugs | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Molten Metal Solidifies into a New Kind of Glass Molten Metal Solidifies into a New Kind of Glass Organic Polymers Show Sunny Potential A New Family of Quasicrystals Cool Muscles: Storing Elastic Energy for Flight A Further Understanding of Superconductivity Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor, which could help scientists design new drugs for type 2 diabetes. (Image courtesy of Katya Kadyshevskaya, The Scripps Research Institute) The three-dimensional (3-D) atomic structure of the human glucagon receptor has been identified by an international team of researchers carrying out

425

Computer modeling reveals how surprisingly potent hepatitis C drug works  

NLE Websites -- All DOE Office Websites (Extended Search)

Hepatitis C computer modeling Hepatitis C computer modeling Computer modeling reveals how surprisingly potent hepatitis C drug works A study reveals how daclatasvir targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment. February 19, 2013 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

426

SF 6432-TM Standard Terms and Conditions for Time and Materials Labor Hour Contracts  

NLE Websites -- All DOE Office Websites (Extended Search)

TM (04-95) TM (04-95) Sections II & III SECTION II STANDARD TERMS AND CONDITIONS FOR TIME AND MATERIAL OR LABOR HOURS CONTRACTS INDEX OF CLAUSES THE FOLLOWING CLAUSES APPLY TO THIS CONTRACT AS INDICATED UNLESS SPECIFICALLY DELETED, OR EXCEPT TO THE EXTENT THEY ARE SPECIFICALLY SUPPLEMENTED OR AMENDED IN WRITING IN THE SIGNATURE PAGE OR SECTION I. No. Title Page "A" Clauses apply to Requests for Quotation and Contracts at any value A10 Definitions 2 A11 Unclassified Contract 2 A12 Assignment 2 *A13 Releases Void 2 *A14 Notice of Labor Disputes 2 *A16 Contractor's Information 2 A17 Delegated Representatives 2 *A18 Defense Priority and Allocation System 2 A19 Terms and Conditions 3 *A20 Permits 3 *A23 Applicable Law 3 *A24 Contractor Records Retention 3 A25 Commerce in Explosives, Firearms and

427

Use of Preventative and Therapeutic Drugs in Show Market Animals  

E-Print Network (OSTI)

Various preventive and therapeutic medicines may be used for disease management in show mar- ket livestock and poultry. These include vaccines and bacterins, antibiotics and antibacterials, para- siticides and corticosteroids. Exhibitors of show ani.... These instructions are to be followed precisely. L-2335 2-01 Use of Preventive and Therapeutic Drugs in Show Market Animals F.C. Faries, Jr. Associate Professor and Extension Program Leader for Veterinary Medicine The Texas A&M University System Testing The Food...

Faries Jr., Floron C.

2001-03-12T23:59:59.000Z

428

The fibrate drug gemfibrozil disrupts lipoprotein metabolism in rainbow trout  

SciTech Connect

Gemfibrozil (GEM) is a fibrate drug consistently found in effluents from sewage treatment plants. This study characterizes the pharmacological effects of GEM on the plasma lipoproteins of rainbow trout (Oncorhynchus mykiss). Our goals were to quantify the impact of the drug on: 1) lipid constituents of lipoproteins (phospholipids (PL), triacylglycerol (TAG), and cholesterol), 2) lipoprotein classes (high, low and very low density lipoproteins), and 3) fatty acid composition of lipoproteins. Potential mechanisms of GEM action were investigated by measuring lipoprotein lipase activity (LPL) and the hepatic gene expression of LPL and of the peroxisome proliferator-activated receptor (PPAR) {alpha}, {beta}, and {gamma} isoforms. GEM treatment resulted in decreased plasma lipoprotein levels (- 29%) and a reduced size of all lipoprotein classes (lower PL:TAG ratios). However, the increase in HDL-cholesterol elicited by GEM in humans failed to be observed in trout. Therefore, HDL-cholesterol cannot be used to assess the impact of the drug on fish. GEM also modified lipoprotein composition by reducing the abundance of long-chain n-3 fatty acids, thereby potentially reducing the nutritional quality of exposed fish. The relative gene expression of LPL was increased, but the activity of the enzyme was not, and we found no evidence for the activation of PPAR pathways. The depressing effects of GEM on fish lipoproteins demonstrated here may be a concern in view of the widespread presence of fibrates in aquatic environments. Work is needed to test whether exposure to environmental concentrations of these drugs jeopardizes the capacity of fish for reproduction, temperature acclimation or migratory behaviors.

Prindiville, John S., E-mail: jprin041@uottawa.ca; Mennigen, Jan A.; Zamora, Jake M.; Moon, Thomas W.; Weber, Jean-Michel

2011-03-15T23:59:59.000Z

429

Consolidation effect of the processing of declarative knowledge during human sleep: evidence from long-term retention of interrelated contents of mental sleep experiences  

Science Journals Connector (OSTI)

Sleep may partly exert a positive influence on memory through the processing underlying the transformation of items of declarative knowledge into contents of mental sleep experience (MSE). This hypothesis implies that the level of consolidation (and thus, long-term retention) should be enhanced for those items which are repeatedly processed and transformed into identical or very similar (so-called interrelated) contents of distinct \\{MSEs\\} developed over the same night. To test this prediction, we examined accessibility at delayed recall (i.e., the next morning) of the interrelated contents of \\{MSEs\\} reported (immediate recall) by 14 subjects who were awakened during the first four periods of rapid eye-movement (REM) sleep in two experimental nights. Interrelated contents were much more frequent, and at delayed recall much better retained, than other, non-interrelated contents in report pairs of MSEs. Moreover, they were also more frequent and better retained than by-chance similar or identical contents, as estimated in report pairs of \\{MSEs\\} of different subjects. These findings provide partial but coherent evidence in favour of the hypothesis that a generation effect occurs during sleep, with a further consolidation of the input and the output of MSE processing (respectively, the items of declarative knowledge and the contents of \\{MSEs\\} resulting from their elaboration during sleep).

Carlo Cipolli; Igino Fagioli; Michela Mazzetti; Giovanni Tuozzi

2005-01-01T23:59:59.000Z

430

Exploiting VERITAS Timing Information  

E-Print Network (OSTI)

The 499 pixel photomultiplier cameras of the VERITAS gamma ray telescopes are instrumented with 500MHz sampling Flash ADCs. This paper describes a preliminary investigation of the best methods by which to exploit this information so as to optimize the signal-to-noise ratio for the detection of Cherenkov light pulses. The FADCs also provide unprecedented resolution for the study of the timing characteristics of Cherenkov images of cosmic-ray and gamma-ray air showers. This capability is discussed, together with the implications for gamma-hadron separation.

J. Holder; for the VERITAS Collaboration

2005-07-19T23:59:59.000Z

431

Invariant time-series factorization  

Science Journals Connector (OSTI)

Time-series analysis is an important domain of machine learning and a plethora of methods have been developed for the task. This paper proposes a new representation of time series, which in contrast to existing approaches, decomposes a time-series dataset ... Keywords: Data mining, Time-series classification, Time-series factorization

Josif Grabocka; Lars Schmidt-Thieme

2014-09-01T23:59:59.000Z

432

Accurate-Mass Databases for Comprehensive Screening of Pesticide Residues in Food by Fast Liquid Chromatography Time-of-Flight Mass Spectrometry  

Science Journals Connector (OSTI)

The use of agrochemicals at various stages of cultivation has an important impact in food protection and quality preservation. ... The chromatographic method held the initial mobile phase composition (10% B) constant for 1 min, followed by a linear gradient to 100% B up to 12 min, and kept for 5 min at 100% B. The flow rate used was 0.6 mL min?1. ... Accurate-Mass Database of the Studied Pesticides Including Retention Times (RT), Theoretical Accurate Masses, and Elemental Compositions of the Detected Ions ...

Milagros Mezcua; Octavio Malato; Juan F. Garca-Reyes; Antonio Molina-Daz; Amadeo R. Fernndez-Alba

2008-12-31T23:59:59.000Z

433

Stigma trajectories among people living with HIV (PLHIV) embarking on a life time journey with antiretroviral drugs in Jinja, Uganda  

E-Print Network (OSTI)

therapy in Jinja, Uganda. Cult Health Sexuality 2011, 13(5):of HIV and AIDS in Rakai, Uganda. 19751990. Afr J AIDS Restested HIV negative in Uganda. Sociol Health Illn 2011, 36.

Mbonye, Martin; Nakamanya, Sarah; Birungi, Josephine; King, Rachel; Seeley, Janet; Jaffar, Shabbar

2013-01-01T23:59:59.000Z

434

Genetic variation of the HIV-1 integrase region in newly diagnosed anti-retroviral drug-nave patients with HIV/AIDS in Korea  

Science Journals Connector (OSTI)

Abstract The survival time of HIV/AIDS patients in Korea has increased since HAART (highly active anti-retroviral therapy) was introduced. However, the occurrence of drug-resistant strains requires new anti-retroviral drugs, one of which, an integrase inhibitor (INI), was approved by the US Food and Drug Administration (FDA) in 2007. \\{INIs\\} have been used for therapy in many countries and are about to be employed in Korea. Therefore, it is important to identify basic mutant variants prior to the introduction of \\{INIs\\} in order to estimate their efficacy. To monitor potential drug-resistant INI mutations in Korean HIV/AIDS patients, the polymorphism of the int gene was investigated together with the pol gene using a genotypic assay for 75 randomly selected Korean HIV-1 patients newly diagnosed in 2007. The drug-resistant mutation sequences were analysed using the Stanford HIV DB and the International AIDS Society resistance testing-USA panel (IAS-USA). Seventy strains of Korean subtype B were compared with foreign subtype-B strains, and there were no significantly different variants of the int gene region in the study population. Major mutation sites in the integrase (E92Q, F121Y, G140A/S, Y143C/R, Q148H/R/K and N155H) were not detected, and only a few minor mutation sites (L74M, V151I, E157Q, V165I, I203M, S230N and D232N) were identified in 21 strains (28%). Resistance due to mutations in the pol gene was observed in a single strain (1.3%) resistant to protease inhibitors (PIs) and in four strains (5.3%) resistant to reverse transcriptase inhibitors (RTIs). In summary, this demonstrates that \\{INIs\\} will be susceptible to drug nave HIV/AIDS patients in Korea.

J.-Y. Kim; E.-J. Kim; J.-Y. Choi; O.-K. Kwon; G.J. Kim; S.Y. Choi; S.S. Kim

2011-01-01T23:59:59.000Z

435

Real time automated inspection  

DOE Patents (OSTI)

A method and apparatus relating to the real time automatic detection and classification of characteristic type surface imperfections occurring on the surfaces of material of interest such as moving hot metal slabs produced by a continuous steel caster. A data camera transversely scans continuous lines of such a surface to sense light intensities of scanned pixels and generates corresponding voltage values. The voltage values are converted to corresponding digital values to form a digital image of the surface which is subsequently processed to form an edge-enhanced image having scan lines characterized by intervals corresponding to the edges of the image. The edge-enhanced image is thresholded to segment out the edges and objects formed by the edges are segmented out by interval matching and bin tracking. Features of the objects are derived and such features are utilized to classify the objects into characteristic type surface imperfections.

Fant, Karl M. (Minneapolis, MN); Fundakowski, Richard A. (Saint Paul, MN); Levitt, Tod S. (Minneapolis, MN); Overland, John E. (Plymouth, MN); Suresh, Bindinganavle R. (New Brighton, MN); Ulrich, Franz W. (Minneapolis, MN)

1985-01-01T23:59:59.000Z

436

Real time automated inspection  

DOE Patents (OSTI)

A method and apparatus are described relating to the real time automatic detection and classification of characteristic type surface imperfections occurring on the surfaces of material of interest such as moving hot metal slabs produced by a continuous steel caster. A data camera transversely scans continuous lines of such a surface to sense light intensities of scanned pixels and generates corresponding voltage values. The voltage values are converted to corresponding digital values to form a digital image of the surface which is subsequently processed to form an edge-enhanced image having scan lines characterized by intervals corresponding to the edges of the image. The edge-enhanced image is thresholded to segment out the edges and objects formed by the edges by interval matching and bin tracking. Features of the objects are derived and such features are utilized to classify the objects into characteristic type surface imperfections. 43 figs.

Fant, K.M.; Fundakowski, R.A.; Levitt, T.S.; Overland, J.E.; Suresh, B.R.; Ulrich, F.W.

1985-05-21T23:59:59.000Z

437

Time encoded radiation imaging  

DOE Patents (OSTI)

The various technologies presented herein relate to detecting nuclear material at a large stand-off distance. An imaging system is presented which can detect nuclear material by utilizing time encoded imaging relating to maximum and minimum radiation particle counts rates. The imaging system is integrated with a data acquisition system that can utilize variations in photon pulse shape to discriminate between neutron and gamma-ray interactions. Modulation in the detected neutron count rates as a function of the angular orientation of the detector due to attenuation of neighboring detectors is utilized to reconstruct the neutron source distribution over 360 degrees around the imaging system. Neutrons (e.g., fast neutrons) and/or gamma-rays are incident upon scintillation material in the imager, the photons generated by the scintillation material are converted to electrical energy from which the respective neutrons/gamma rays can be determined and, accordingly, a direction to, and the location of, a radiation source identified.

Marleau, Peter; Brubaker, Erik; Kiff, Scott

2014-10-21T23:59:59.000Z

438

SAMPLING AND MASS SPECTROMETRY APPROACHES FOR THE DETECTION OF DRUGS AND FOREIGN CONTAMINANTS IN BREATH FOR HOMELAND SECURITY APPLICATIONS  

SciTech Connect

Homeland security relies heavily on analytical chemistry to identify suspicious materials and persons. Traditionally this role has focused on attribution, determining the type and origin of an explosive, for example. But as technology advances, analytical chemistry can and will play an important role in the prevention and preemption of terrorist attacks. More sensitive and selective detection techniques can allow suspicious materials and persons to be identified even before a final destructive product is made. The work presented herein focuses on the use of commercial and novel detection techniques for application to the prevention of terrorist activities. Although drugs are not commonly thought of when discussing terrorism, narcoterrorism has become a significant threat in the 21st century. The role of the drug trade in the funding of terrorist groups is prevalent; thus, reducing the trafficking of illegal drugs can play a role in the prevention of terrorism by cutting off much needed funding. To do so, sensitive, specific, and robust analytical equipment is needed to quickly identify a suspected drug sample no matter what matrix it is in. Single Particle Aerosol Mass Spectrometry (SPAMS) is a novel technique that has previously been applied to biological and chemical detection. The current work applies SPAMS to drug analysis, identifying the active ingredients in single component, multi-component, and multi-tablet drug samples in a relatively non-destructive manner. In order to do so, a sampling apparatus was created to allow particle generation from drug tablets with on-line introduction to the SPAMS instrument. Rules trees were developed to automate the identification of drug samples on a single particle basis. A novel analytical scheme was also developed to identify suspect individuals based on chemical signatures in human breath. Human breath was sampled using an RTube{trademark} and the trace volatile organic compounds (VOCs) were preconcentrated using solid phase microextraction (SPME) and identified using gas chromatography - mass spectrometry (GC-MS). Modifications to the sampling apparatus allowed for increased VOC collection efficiency, and reduced the time of sampling and analysis by over 25%. The VOCs are present in breath due to either endogenous production, or exposure to an external source through absorption, inhalation, or ingestion. Detection of these exogenous chemicals can provide information on the prior location and activities of the subject. Breath samples collected before and after exposure in a hardware store and nail salon were analyzed to investigate the prior location of a subject; breath samples collected before and after oral exposure to terpenes and terpenoid compounds, pseudoephedrine, and inhalation exposure to hexamine and other explosive related compounds were analyzed to investigate the prior activity of a subject. The elimination of such compounds from the body was also monitored. In application, this technique may provide an early warning system to identify persons of interest in the prevention and preemption stages of homeland security.

Martin, A N

2009-01-27T23:59:59.000Z

439

Manganese-loaded lipid-micellar theranostics for simultaneous drug and gene delivery to lungs  

Science Journals Connector (OSTI)

Abstract Gadolinium (Gd) contrast agents are predominantly used for T1 MR imaging. However, the high toxicity of Gd3+ and potential side effects including nephrogenic systemic fibrosis have led to the search for alternative T1 contrast agents. Since manganese (Mn) has paramagnetic properties with five unpaired electrons that permit high spin number, long electronic relaxation times, and labile water exchange, we evaluated Mn as a T1 magnetic resonance imaging (MRI) contrast agent for lung imaging. Here we report on the design and synthesis of multifunctional lipid-micellar nanoparticles (LMNs) containing Mn oxide (M-LMNs) for MRI that can also be used for DNA and drug delivery. Oleic acid-coated MnO nanoparticles were encapsulated in micelles composed of polyethylene glycol (PEG-2000), phosphatidylethanolamine (PE), DC-cholesterol, and dioleoyl-phosphatidylethanolamine (DOPE). The particles are taken up in vitro by human embryonic kidney (HEK293), Lewis lung carcinoma (LLC1), and A549 cells and are devoid of cytotoxicity. When administered to mice intranasally, they preferentially accumulate in the lungs. In vitro phantom and ex vivo lung MRI results confirmed that M-LMNs are able to enhance T1 MRI contrast. M-LMNs loaded with plasmid DNA and/or doxorubicin are efficiently taken up by HEK293 cells in vitro and by target cells in vivo. Taken together, these results demonstrate that M-LMNs are capable of simultaneously providing MRI contrast and DNA and/or drug delivery to target cells in the lung and therefore may prove useful as a lung theranostic, especially for lung cancers.

M. Howell; J. Mallela; C. Wang; S. Ravi; S. Dixit; U. Garapati; S. Mohapatra

2013-01-01T23:59:59.000Z

440

SLH Timing Belt Powertrain  

SciTech Connect

The main goal of this proposal was to develop and test a novel powertrain solution for the SLH hydroEngine?, a low-cost, efficient low-head hydropower technology. Nearly two-thirds of U.S. renewable electricity is produced by hydropower (EIA 2010). According to the U.S. Department of Energy; this amount could be increased by 50% with small hydropower plants, often using already-existing dams (Hall 2004). There are more than 80,000 existing dams, and of these, less than 4% generate power (Blankinship 2009). In addition, there are over 800 irrigation districts in the U.S., many with multiple, non-power, low-head drops. These existing, non-power dams and irrigation drops could be retrofitted to produce distributed, baseload, renewable energy with appropriate technology. The problem is that most existing dams are low-head, or less than 30 feet in height (Ragon 2009). Only about 2% of the available low-head hydropower resource in the U.S. has been developed, leaving more than 70 GW of annual mean potential low-head capacity untapped (Hall 2004). Natel Energy, Inc. is developing a low-head hydropower turbine that operates efficiently at heads less than 6 meters and is cost-effective for deployment across multiple low-head structures. Because of the unique racetrack-like path taken by the prime-movers in the SLH, a flexible powertrain is required. Historically, the only viable technological solution was roller chain. Despite the having the ability to easily attach blades, roller chain is characterized by significant drawbacks, including high cost, wear, and vibration from chordal action. Advanced carbon-#12;fiber-reinforced timing belts have been recently developed which, coupled with a novel belt attachment system developed by Natel Energy, result in a large reduction in moving parts, reduced mass and cost, and elimination of chordal action for increased fatigue life. The work done in this project affirmatively addressed each of the following 3 major uncertainties concerning a timing-belt based hydroEngine ?powertrain: 1. Can a belt handle the high torques and power loads demanded by the SLH? (Yes.) 2. Can the SLH blades be mounted to belt with a connection that can withstand the loads encountered in operation? (Yes.) 3. Can the belt, with blade attachments, live through the required cyclic loading? (Yes.) The research adds to the general understanding of sustainable small hydropower systems by using innovative system testing to develop and demonstrate performance of a novel powertrain solution, enabling a new type of hydroelectric turbine to be commercially developed. The technical effectiveness of the methods investigated has been shown to be positive through an extensive design and testing process accommodating many constraints and goals, with a major emphasis on high cycle fatigue life. Economic feasibility of the innovations has been demonstrated through many iterations of design for manufacturability and cost reduction. The project is of benefit to the public because it has helped to develop a solution to a major problem -- despite the large available potential for new low-head hydropower, high capital costs and high levelized cost of electricity (LCOE) continue to be major barriers to project development. The hydroEngine? represents a significant innovation, leveraging novel fluid mechanics and mechanical configuration to allow lower-cost turbine manufacture and development of low head hydropower resources.

Schneider, Abe

2014-04-09T23:59:59.000Z

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441

Local drug delivery for enhancing fracture healing in osteoporotic bone  

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Abstract Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an osteoporotic fracture is challenging due to the decreased strength of the surrounding bone and suboptimal healing capacity, predisposing both to fixation failure and non-union. Whereas a systemic osteoporosis treatment acts slowly, local release of osteogenic agents in osteoporotic fracture would act rapidly to increase bone strength and quality, as well as to reduce the bone healing period and prevent development of a problematic non-union. The identification of agents with potential to stimulate bone formation and improve implant fixation strength in osteoporotic bone has raised hope for the fast augmentation of osteoporotic fractures. Stimulation of bone formation by local delivery of growth factors is an approach already in clinical use for the treatment of non-unions, and could be utilized for osteoporotic fractures as well. Small molecules have also gained ground as stable and inexpensive compounds to enhance bone formation and tackle osteoporosis. The aim of this paper is to present the state of the art on local drug delivery in osteoporotic fractures. Advantages, disadvantages and underlying molecular mechanisms of different active species for local bone healing in osteoporotic bone are discussed. This review also identifies promising new candidate molecules and innovative approaches for the local drug delivery in osteoporotic bone.

Laura Kyllnen; Matteo DEste; Mauro Alini; David Eglin

2014-01-01T23:59:59.000Z

442

First-passage-time problems in time-aware networks  

E-Print Network (OSTI)

First passage time or the first time that a stochastic process crosses a boundary is a random variable whose probability distribution is sought in engineering, statistics, finance, and other disciplines. The probability ...

Suwansantisuk, Watcharapan, 1978-

2012-01-01T23:59:59.000Z

443

Multiscale modeling and uncertainty quantification in nanoparticle-mediated drug/gene delivery  

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Nanoparticle (NP)-mediated drug/gene delivery involves phenomena at broad range spatial and temporal scales. The interplay between these phenomena makes the NP-mediated drug/gene delivery process very complex. In this paper, we have identified four key ... Keywords: Coarse-grained molecular dynamics, Drug delivery, Fluid-structure interaction, Immersed molecular electrokinetic finite element, Molecular mean-field theory, Multiscale modeling

Ying Li, Wylie Stroberg, Tae-Rin Lee, Han Sung Kim, Han Man, Dean Ho, Paolo Decuzzi, Wing Kam Liu

2014-03-01T23:59:59.000Z

444

A client management system for criminal justice referrals to drug abuse treatment  

E-Print Network (OSTI)

. These modalities included methadone maintenance (MM), outpatient drug-free (DF), therapeutic community (TC), and short-term detoxification (DT). In a review of findings in 1979, Sel ls described each of the four modalities. Methadone maintenance programs... over the years of research. Therapeutic communities are typically residential, drug-free programs offering 24-hour care and they concentrate on rehabilitation through resocialization of the addict toward more adaptive and productive pursuits. Drug...

Pate, Wayland Gordon

2012-06-07T23:59:59.000Z

445

Report: Employee Recruitment and Retention  

Office of Environmental Management (EM)

to retrain and develop current employees. Recommendation 2006-05: Develop advanced management training modules and review the DOD's career development processes to devise a...

446

ORISE Research Participation Programs at the U.S. Food and Drug...  

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Research Participation Programs at the U.S. Food and Drug Administration (FDA) Home About FDA About ORISE Current Research Opportunities Site Map Contact ORISE Facebook Twitter...

447

E-Print Network 3.0 - antiepileptic drugs carbamazepine Sample...  

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for: antiepileptic drugs carbamazepine Page: << < 1 2 3 4 5 > >> 1 Folic acid sensitive birth defects in association with intrauterine exposure to folic acid Summary: to...

448

E-Print Network 3.0 - antiarrhythmic drug therapy Sample Search...  

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Collection: Biology and Medicine 13 TEXAS A&M UNIVERSITY LIBRARIES CITING THE INTERNET USING CSE STYLE Summary: Institute on Drug Abuse (US); 1994 revised 2000 Jul; cited...

449

E-Print Network 3.0 - act drug policies Sample Search Results  

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and Immunology, Stanford University Collection: Biology and Medicine 14 BRIGHAM YOUNG UNIVERSITY Report of Institutional Compliance with the Drug-Free Schools and...

450

E-Print Network 3.0 - antiviral drug design Sample Search Results  

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of Pharmacology and Pharmaceutical Sciences. his research interests include drug design and discovery, database mining of small- Summary: an internationally recognized...

451

Drug trafficking and gun carrying: a co-occurring phenomenon among urban male youth.  

E-Print Network (OSTI)

??This study examines an often-observed, but rarely studied, phenomenon of drug trafficking and gun carrying behaviors among urban male youth, as much of social science (more)

Allen, Andrea Nicole

2009-01-01T23:59:59.000Z

452

E-Print Network 3.0 - anti-tuberculosis drug resistance Sample...  

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University Collection: Biology and Medicine 10 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

453

E-Print Network 3.0 - anti-inflammatory drug naproxen Sample...  

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Collection: Biology and Medicine ; Environmental Sciences and Ecology 47 Management of gout Chapter 2.1 Summary: - inflammatory drugs (glucocorticosteroids, colchicine, and...

454

E-Print Network 3.0 - anti-inflammatory drug-induced ulcer Sample...  

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<< < 1 2 3 4 5 > >> Page: << < 1 2 3 4 5 > >> 61 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: episodic arthritis, which...

455

E-Print Network 3.0 - anti-inflammatory drug etoricoxib Sample...  

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Vanderbilt University Collection: Biology and Medicine ; Chemistry 4 Management of gout Chapter 2.1 Summary: - inflammatory drugs (glucocorticosteroids, colchicine, and...

456

E-Print Network 3.0 - antituberculosis drug-induced hepatotoxicity...  

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Collection: Biology and Medicine ; Mathematics 14 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

457

E-Print Network 3.0 - anti-tuberculosis drug ethionamide Sample...  

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Harvard University Collection: Biology and Medicine 5 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

458

E-Print Network 3.0 - antituberculosis drugs carriers Sample...  

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Harvard University Collection: Biology and Medicine 3 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: Practice research in the...

459

E-Print Network 3.0 - antituberculosis drug resistance Sample...  

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British Columbia Collection: Biology and Medicine 12 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: Practice research in the...

460

E-Print Network 3.0 - adrs adverse drug Sample Search Results  

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and Medicine ; Environmental Sciences and Ecology 60 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: Practice research in the...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
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they are not comprehensive nor are they the most current set.
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to obtain the most current and comprehensive results.


461

E-Print Network 3.0 - adverse drug interactions Sample Search...  

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Sciences and Ecology 12 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School Summary: ; Early labels decorative Drug...

462

E-Print Network 3.0 - antibacterial drug resistances Sample Search...  

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Exposing plasmids as the Achilles' heel of drug-resistant bacteria Summary: in the pharmaceutical industry away from the development of novel antibacterials 4,5. New...

463

E-Print Network 3.0 - anti-infective drugs advisory Sample Search...  

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drug classes of anti-infectives and their mechanisms of action... advisory role or in the pharmaceutical industry. An interest in antibiotic prescribing practice... changes to...

464

E-Print Network 3.0 - anticholinergic antiparkinson drugs Sample...  

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4 5 > >> 1 Arch Intern Med . Author manuscript Drugs with anticholinergic properties, cognitive decline, and dementia in Summary: Arch Intern Med . Author manuscript Page 1 14...

465

E-Print Network 3.0 - antipsychotic drug treatment Sample Search...  

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and Medicine 38 PHARMACOGENETICS OF PARKINSONISM, RIGIDITY, Summary: Fleischhacker, W.W., Meise, U., Gunther, V., and Kurz, M. (1994). Compliance with antipsychotic drug...

466

Mold-Templated InorganicOrganic Hybrid Supraparticles for Codelivery of Drugs  

Science Journals Connector (OSTI)

Mold-Templated InorganicOrganic Hybrid Supraparticles for Codelivery of Drugs ... The Bionics Institute acknowledges funding from the Victorian Government's Operational Infrastructure Support Program. ...

James W. Maina; Jiwei Cui; Mattias Bjrnmalm; Andrew K. Wise; Robert K. Shepherd; Frank Caruso

2014-10-16T23:59:59.000Z

467

E-Print Network 3.0 - antimicrobial drug resistance Sample Search...  

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Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

468

E-Print Network 3.0 - antimicrobial drug resistanceestudio Sample...  

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Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

469

E-Print Network 3.0 - aetiology antimicrobial drug Sample Search...  

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Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

470

E-Print Network 3.0 - anti-malarial drug precursor Sample Search...  

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JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

471

E-Print Network 3.0 - anti-malarial drug quality Sample Search...  

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JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

472

E-Print Network 3.0 - anti-malarial drug sensitivity Sample Search...  

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JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

473

E-Print Network 3.0 - anti-hiv drug regimens Sample Search Results  

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body's natural anti-HIV immune... , there are no therapeutic HIV vaccines approved by the Food and DrugAdministration (FDA). However, therapeutic HIV vaccines... response, people...

474

E-Print Network 3.0 - anticancer drug discovery Sample Search...  

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2 From the University of Mississippi Medical Center Division of Public Affairs ANTI-CANCER DRUG DISCOVERY PARTNERSHIP FORMED BETWEEN UMMC CANCER INSTITUTE AND Summary: From the...

475

E-Print Network 3.0 - antihypertensive drug treatment Sample...  

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the medical treatment of vascular risk factors. Cardiovasc Drugs Ther 2005 Dec... , Stricker BHC, Leufkens HGM, de Boer A. Methods to assess intended effects of ... Source:...

476

E-Print Network 3.0 - antimalaria drug mefloquine Sample Search...  

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EP van, Heeringa M. Bijwerkingen van mefloquine. Onrust ondermijnt objectieve... , Stricker BHC. Attitudinal survey of voluntary reporting of adverse drug reactions. Br J Clin...

477

Plasmonic Nanobubble Theranostics: Detection and Destruction of Drug-Resistant Tumors in a Single Rapid Procedure  

Science Journals Connector (OSTI)

On-demand plasmonic nanobubbles combine highly sensitive detection and guided destruction of drug-resistant tumors, minimize non-specific toxicity in a rapid theranostic procedure that...

Lapotko, Dmitri

478

Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.  

E-Print Network (OSTI)

?? The purpose of this study was to design, synthesize and develop novel transporter targeting agents for image-guided therapy and drug delivery. Two novel agents, (more)

Tsao, Ning

2013-01-01T23:59:59.000Z

479

Novel Polysaccharide Based Polymers and Nanoparticles for Controlled Drug Delivery and Biomedical Imaging.  

E-Print Network (OSTI)

??The use of polysaccharides as building blocks in the development of drugs and contrast agents delivery systems is rapidly growing. This can be attributed to (more)

Shalviri, Alireza

2013-01-01T23:59:59.000Z

480

E-Print Network 3.0 - atovaquone drug resistance Sample Search...  

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spontaneously arising muta- tions that confer resistance to the drug 39. In principle... the molecular basis of atovaquone resistance in parasites and ... Source: Trumpower,...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

E-Print Network 3.0 - antithyroid drugs Sample Search Results  

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Perchlorate Drugs like tamoxifen, nafoxidine Persistent organic pollutants such as dioxins... water sup- plies have measurable levels of residues from various prescription...

482

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates  

Science Journals Connector (OSTI)

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates ... In the present work we sought to gain a mechanistic understanding of the physicochemical properties that influence the transport of unbound drug across the blood-brain barrier (BBB) as well as the intra- and extracellular drug exposure in the brain. ... Interpretable molecular descriptors that significantly contribute to the three key neuropharmacokinetic properties related to BBB drug transport (Kp,uu,brain), intracellular accumulation (Kp,uu,cell) and binding and distribution in the brain (Vu,brain) for a set of 40 compounds were identified using partial least squares (PLS) analysis. ...

Irena Loryan; Vikash Sinha; Claire Mackie; Achiel van Peer; Wilhelmus H. Drinkenburg; An Vermeulen; Donald Heald; Margareta Hammarlund-Udenaes; Carola M. Wassvik

2014-12-15T23:59:59.000Z

483

E-Print Network 3.0 - antiretroviral drug-naive children Sample...  

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HIV in Summary: EDITORIAL REVIEW The antiretroviral rollout and drug-resistant HIV in Africa: insights from... is to provide antiretroviral treatment (ART) to millions. Here, we...

484

Dust time in quantum cosmology  

E-Print Network (OSTI)

We give a formulation of quantum cosmology with a pressureless dust and arbitrary additional matter fields. The dust provides a natural time gauge corresponding to a cosmic time, yielding a physical time independent Hamiltonian. The approach simplifies the analysis of both Wheeler-deWitt and loop quantum cosmology models, broadening the applicability of the latter.

Husain, Viqar

2013-01-01T23:59:59.000Z

485

Myeloablative 131I-Tositumomab Radioimmunotherapy in Treating Non-Hodgkins Lymphoma: Comparison of Dosimetry Based on Whole-Body Retention and Dose to Critical Organ Receiving the Highest Dose  

SciTech Connect

Objectives: Myeloablative radioimmunotherapy (RIT) using 131I tositumomab (anti-CD 20) monoclonal antibodies is an effective new therapy for B-cell non-Hodgkins lymphoma (NHL). The goal of this work is to determine optimum methods to deliver maximal myeloablative radioactivity without exceeding the radiation tolerance of critical normal organs such as liver and lungs, and avoiding serious toxicity. Methods: We reviewed dosimetry records for 100 consecutive patients who underwent biodistribution and dosimetry after a test infusion of 131I- tositumomab. Serial gamma camera images were used to determine organ and tissue activities over time and to calculate radiation-absorbed doses. Volumes of critical normal organs were determined from CT scans to adjust the dose estimates for the individual patient. These dose estimates helped us determine an appropriate therapy based on projected dose to the critical normal organ receiving a maximum tolerable radiation dose. We compared our method of organ-specific dosimetry for treatment planning with the standard clinical approaches using a whole-body dose-assessment method by assessing the difference in projected amounts of radiation-absorbed doses, as well as the ratios of projected amounts, that would be prescribed for therapy by each of these two strategies. Results: The mean organ doses (mGy/MBq) estimated by both methods were (1) Whole body method: liver = 0.33 and lungs = 0.33; and (2) Organ-specific method: liver 1.52 and lungs 1.72 (p = .0001). The median difference between the radiation-absorbed dose estimates was 3.40 (range of 1.37 to 7.96) for the lungs, 3.05 (range of 1.04 to 6.20) for the liver, and 0.05 for whole body (range of 0.18 to 0.16). The median ratio (OS divided by WB method) of radiation-absorbed dose estimates was 5.12 (range of 2.33 to 10.01) for the lungs, 4.14 (range of 2.16 to 6.67) for the liver, and 0.94 (range of 0.79 to 1.22) for whole body. There was significant difference between the dose estimated by the two methods for liver and lungs (p = 0.0001) and a significant correlation for whole body dose estimates by the two methods (R = 0.97) indicating confidence in the whole body dose estimation methods. Conclusions: Dosimetry based only on whole body retention will under-estimate the organ doses in a substantial number of patients, likely because it assumes a uniform distribution and clearance without accounting for patient-specific variations in biodistribution. Myeloablative treatment based on individual organ radiation absorbed dose provides the ability to safely administer the largest possible amounts of radioactivity and deliver an optimized radiation dose to tumor within the tolerance of normal organs.

Rajendran, Joseph G.; Gopal, Ajay K.; Fisher, Darrell R.; Durack, L. D.; Gooley, Ted; Press, Oliver W.

2008-05-01T23:59:59.000Z

486

Shedding Light on Protein Drug Interactions | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Science Highlights Archives: 2013 | 2012 | 2011 | 2010 Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Shedding Light on Protein Drug Interactions JANUARY 23, 2008 Bookmark and Share In this e-coli cell, the proteins (shown in blue) crowd around ribosomes (purple). These regions have a high concentration of protein, typically greater than 30 percent, which limits the ensemble of states into which the proteins can bend themselves. Download hi-res image.) Proteins, the biological molecules that are involved in virtually every action of every organism, may themselves move in surprising ways, according to a recent study carried out at the Biophysics Collaborative Access Team x-ray beamline 18-ID at the Advanced Photon Source, a national user

487

Prevalence of serologic markers of HBV, HDV, HCV and HIV in non-injection drug users compared to injection drug users in Gran Canaria, Spain  

Science Journals Connector (OSTI)

Injection drug use (IDU) is one of the most significant risk factors for viral hepatitis (B, D and C) and human immunodeficiency virus (HIV) infection. However, there is little information about the risk of infec...

Otilia Evora Santana Rodrguez; Mara Luisa Mal Gil

1998-09-01T23:59:59.000Z

488

ATHENA desktop human "body" reduces need for animal drug tests  

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methane levels three times larger than expected over Four Corners region Probing Fukushima with cosmic rays should help speed cleanup of damaged plant Dark spaces could change...

489

Detection and Quantification of New Designer Drugs in Human Blood: Part 2 Designer Cathinones  

Science Journals Connector (OSTI)

......marketed over the internet or in so-called...fatalities due to the abuse of these drugs in...available over the internet or in so-called...17, 18). The abuse of cathinone-derived...marketed over the internet or in so-called...fatalities due to the abuse of these drugs in recent......

Dominic Ammann; Jenna M. McLaren; Dimitri Gerostamoulos; Jochen Beyer

2012-07-01T23:59:59.000Z

490

Data Warehouse Design for Pharmaceutical Drug Discovery Research Melinda G. Axel and Il-Yeol Song  

E-Print Network (OSTI)

an analysis of the principal activities involved in drug discovery in the pharmaceutical industry, and a setData Warehouse Design for Pharmaceutical Drug Discovery Research Melinda G. Axel and Il-Yeol Song: axel@superlink.net, songiy@post.drexel.edu Abstract Pharmaceutical companies spend billions of dollars

Song, Il-Yeol

491

A New Protocol To Determine the Solubility of Drugs into Polymer Matrixes  

Science Journals Connector (OSTI)

A New Protocol To Determine the Solubility of Drugs into Polymer Matrixes ... For all the experiments, the sample was placed in an open aluminum pan (container with no cover) and was flushed with highly pure nitrogen gas. ... Forster, A.; Hempenstall, J.; Rades, T.Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers J. Pharm. ...

Aurlien Mahieu; Jean-Franois Willart; Emeline Dudognon; Florence Dande; Marc Descamps

2012-12-19T23:59:59.000Z

492

Prevalence and Molecular Characteristics of Drug-Resistant Mycobacterium tuberculosis in Hunan, China  

Science Journals Connector (OSTI)

...Table S2 in the supplemental material). Isolates...Table S3 in the supplemental material. The...Table S10 in the supplemental material. The...regions of tlyA, eis, and gyrB among...region and that the transmission of drug-resistant...percentages of second-line injectable drug...

Li-li Zhao; Yan Chen; Zhong-nan Chen; Hai-can Liu; Pei-lei Hu; Qing Sun; Xiu-qin Zhao; Yi Jiang; Gui-lian Li; Yun-hong Tan; Kang-lin Wan

2014-04-14T23:59:59.000Z

493

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs  

E-Print Network (OSTI)

theranostics Guizhi Zhua,b,c , Jing Zhenga,b , Erqun Songb,d , Michael Donovana , Kejing Zhangb , Chen LiueNTrs a promising targeted drug transport platform for cancer theranostics. self-assembly | DNA nanomedicines). A theranostic (4) platform with targeted and efficient drug transport would solve these problems, and, by its

Tan, Weihong

494

A Trojan horse: Anti-communism and the war on drugs  

Science Journals Connector (OSTI)

This work argues the U.S. War on Drugs is a misnomer. We suggest, instead, that it is secondary to traditional anti-Communist foreign policy concerns. Thus, the war on drugs serves to mask the U.S. counter...

Bruce Bullington; Alan A. Block

1990-03-01T23:59:59.000Z

495

The Drug Transporter?Metabolism Alliance: Uncovering and Defining the Interplay  

Science Journals Connector (OSTI)

The Drug Transporter?Metabolism Alliance: Uncovering and Defining the Interplay ... Work characterizing the rate limiting processes in the drug transporter?metabolism alliance is then addressed, ending with a review of areas of the interplay that require further studies and analysis. ...

Leslie Z. Benet

2009-10-29T23:59:59.000Z

496

Memorandum, Drug Testing at DOE - September 14, 2007 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Memorandum, Drug Testing at DOE - September 14, 2007 Memorandum, Drug Testing at DOE - September 14, 2007 Memorandum, Drug Testing at DOE - September 14, 2007 As established in his memorandum dated September 14, 2007, the Secretary has determined that applicants for, and holders of, a Department of Energy (DOE) Q or L access authorization (security clearance) will be in Testing Designated Positions (TDP) as specified in DOE Order 3792.3, Drug-Free Federal Workplace Testing Implementation Program, for Federal employees, and Title 10, Code of Federal Regulations, Part 707, Workplace Substance Abuse Programs at DOE Sites, for contractor employees. Accordingly, individuals who are either in, or are selected for, a TDP are subject to applicant, random and for cause testing. Additionally, the Secretary has determined individuals who have used illegal drugs within 12

497

Impulsivity in disorders of food and drug misuse  

E-Print Network (OSTI)

-time by the University of Cambridge and part-time by GSK PLC and is a shareholder of GSK. TWR is a consultant for Cambridge Cognition, Eli Lilly, GSK, Merck, Sharpe and Dohme, Lundbeck, Teva and Shire Pharmaceuticals. He is or has been in receipt of research grants...

Mole, T. B.; Irvine, M. A.; Worbe, Y.; Collins, P.; Mitchell, S. P.; Bolton, S.; Harrison, N. A.; Robbins, T. W.; Voon, V.

2014-08-14T23:59:59.000Z

498

Subsystem real-time Time Dependent Density Functional Theory  

E-Print Network (OSTI)

We present the extension of Frozen Density Embedding (FDE) theory to real-time Time Dependent Density Functional Theory (rt-TDDFT). FDE a is DFT-in-DFT embedding method that allows to partition a larger Kohn-Sham system into a set of smaller, coupled Kohn-Sham systems. Additional to the computational advantage, FDE provides physical insight into the properties of embedded systems and the coupling interactions between them. The extension to rt-TDDFT is done straightforwardly by evolving the Kohn-Sham subsystems in time simultaneously, while updating the embedding potential between the systems at every time step. Two main applications are presented: the explicit excitation energy transfer in real time between subsystems is demonstrated for the case of the Na$_4$ cluster and the effect of the embedding on optical spectra of coupled chromophores. In particular, the importance of including the full dynamic response in the embedding potential is demonstrated.

Krishtal, Alisa; Pavanello, Michele

2015-01-01T23:59:59.000Z

499

EMSL - time-of-flight  

NLE Websites -- All DOE Office Websites (Extended Search)

time-flight en Physical Properties of Ambient and Laboratory-Generated Secondary Organic Aerosol. http:www.emsl.pnl.govemslwebpublicationsphysical-properties-ambient-and-labor...

500

Time for money? Prathap Haridoss  

E-Print Network (OSTI)

Time for money? Prathap Haridoss "The more money you earn, the less time you will have to spend, you have to keep enquiring around. To get the maximum money that you possibly can get, you can't just `get a salary', you have to actively work towards increasing your income. Making money can be a full

Krishnapura, Nagendra