Sample records for drug retention times

  1. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  2. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  3. The effect of solids retention time on tertiary ozonation and carbon adsorption of petrochemical wastewaters 

    E-Print Network [OSTI]

    Buys, Ronald Earl

    1980-01-01T23:59:59.000Z

    as solids retention time increased. COD concentration decreased after ozonation and its percent removal increased with a lengthening of the solids retention time, Ozone consumption decreased and the ratio of COD reduction to ozone consumed increased..., with and without ozonation. . . . . . . . . . . . . 22 Effect of solids retention time on COD removal. Effect of solids retention time on ozone concentration consumed. 27 Effect of solids retention time on the ratio of COD reduction to ozone consumed. 28...

  4. Soil Water Retention Measurements Using a Combined Tensiometer-Coiled Time Domain Reflectometry Probe

    E-Print Network [OSTI]

    Wildenschild, Dorthe

    Soil Water Retention Measurements Using a Combined Tensiometer-Coiled Time Domain Reflectometry al., 1975; Arya et al.,that can be used to determine soil water retention curves in both 1975; Royer of a standard tensiometer. The combined tensiometer-coiled TDR probe was con- of soil water retention curves

  5. QSPR models of boiling point, octanolwater partition coefficient and retention time index of polycyclic aromatic hydrocarbons

    E-Print Network [OSTI]

    Ferreira, Márcia M. C.

    QSPR models of boiling point, octanol­water partition coefficient and retention time index Structure­Property Relationship (QSPR) analysis and study of polycyclic aromatic hydrocarbons (PAHs (bp), octanol­ water partition coefficient ðlog KowÞ and retention time index (RI) for reversed

  6. Influence of addition order and contact time on thorium (IV) retention by hematite in the presence

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Influence of addition order and contact time on thorium (IV) retention by hematite.reiller@cea.fr The influence of addition order and contact time in the system hematite (-Fe2O3) ­ humic acid (HA) ­ thorium (IV) was studied in batch experiments. Thorium (IV) is considered here as a chemical analogue of other actinides

  7. Retention Time and the Functional Response of Beavers J. M. Fryxell; S. M. Vamosi; R. A. Walton; C. M. Doucet

    E-Print Network [OSTI]

    Vamosi, Steven

    lower consumption rates than aspen with a short retention time. Net rates of energy gain were also Station, TX 77843-2258, USA1. Theoretical considerations of predation rates in relation tion and energy of food intake and energy gain by beavers. Ad libitum intake rates by beavers were a hyperbolic function

  8. The retention time of inorganic mercury in the brain — A systematic review of the evidence

    SciTech Connect (OSTI)

    Rooney, James P.K., E-mail: jrooney@rcsi.ie

    2014-02-01T23:59:59.000Z

    Reports from human case studies indicate a half-life for inorganic mercury in the brain in the order of years—contradicting older radioisotope studies that estimated half-lives in the order of weeks to months in duration. This study systematically reviews available evidence on the retention time of inorganic mercury in humans and primates to better understand this conflicting evidence. A broad search strategy was used to capture 16,539 abstracts on the Pubmed database. Abstracts were screened to include only study types containing relevant information. 131 studies of interest were identified. Only 1 primate study made a numeric estimate for the half-life of inorganic mercury (227–540 days). Eighteen human mercury poisoning cases were followed up long term including autopsy. Brain inorganic mercury concentrations at death were consistent with a half-life of several years or longer. 5 radionucleotide studies were found, one of which estimated head half-life (21 days). This estimate has sometimes been misinterpreted to be equivalent to brain half-life—which ignores several confounding factors including limited radioactive half-life and radioactive decay from surrounding tissues including circulating blood. No autopsy cohort study estimated a half-life for inorganic mercury, although some noted bioaccumulation of brain mercury with age. Modelling studies provided some extreme estimates (69 days vs 22 years). Estimates from modelling studies appear sensitive to model assumptions, however predications based on a long half-life (27.4 years) are consistent with autopsy findings. In summary, shorter estimates of half-life are not supported by evidence from animal studies, human case studies, or modelling studies based on appropriate assumptions. Evidence from such studies point to a half-life of inorganic mercury in human brains of several years to several decades. This finding carries important implications for pharmcokinetic modelling of mercury and potentially for the regulatory toxicology of mercury.

  9. Residence Time Effects on P Sorption/Desorption on Ferrihydrite Understanding mechanisms of P retention/release on soil mineral surfaces is

    E-Print Network [OSTI]

    Sparks, Donald L.

    Residence Time Effects on P Sorption/Desorption on Ferrihydrite Y. Arai Understanding mechanisms of P retention/release on soil mineral surfaces is fundamental in assessing the P biogeochemistry that are high ammonium oxalate extractable P, due to long-term manure amendments. Since there is a high

  10. The effect of solids retention time on tertiary ozonation and carbon adsorption of petrochemical wastewaters

    E-Print Network [OSTI]

    Buys, Ronald Earl

    1980-01-01T23:59:59.000Z

    . Biological treatment of wastewater has been used since the turn of the century, and while its application has grown in complexity since that time, the fundamental biological reaction mechanisms have remained unchanged. Most important... organic carbon from the wastewater by conversion into microbial cells, or some other desirable form. Biological waste treatment is usually intended for the removal of organic matter, but certain other contaminants are also removed, For example...

  11. Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient

    E-Print Network [OSTI]

    Hinow, Peter

    Summary Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient powders variation in the drug release profile of the tablet. While fabrication of experimental tablets

  12. 174. THE EFFECTS OF RESIDENCE TIME ON THE RETENTION OF ARSENATE BY GOETHITE. S.E. O'Reilly and D.L. Sparks, Department of Plant and Soil Sciences, University

    E-Print Network [OSTI]

    Sparks, Donald L.

    174. THE EFFECTS OF RESIDENCE TIME ON THE RETENTION OF ARSENATE BY GOETHITE. S.E. O'Reilly and D on goethite. Batch sorption and desorption studies were conducted at pH 6 for periods up to 2 months. Arsenate sorption increased slowly with time. As residence time between arsenate and goethite increased

  13. West Virginia University -Main Campus Student Retention and Graduation Rates

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    West Virginia University - Main Campus Student Retention and Graduation Rates First-Time, Full ---------------------------------------------------------------------Continuation Rates and Cumulative Graduation Rates

  14. Time-Resolved SAXS/WAXS Study of the Phase Behavior and Microstructural Evolution of Drug/PEG Solid Dispersions

    SciTech Connect (OSTI)

    Zhu, Qing; Harris, Michael T.; Taylor, Lynne S. (Purdue)

    2013-03-07T23:59:59.000Z

    Simultaneous small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS) was employed to elucidate the physical state and location of various small molecule drugs blended with polyethylene glycol (PEG), as well as the time dependent microstructural evolution of the systems. Samples were prepared by comelting physical mixtures of the drug and PEG, followed by solidification at 25 C. The model drugs selected encompassed a wide variety of physicochemical properties in terms of crystallization tendency and potential for interaction with PEG. It was observed that compounds which crystallized rapidly and had weak interactions with PEG tended to be excluded from the interlamellar region of the PEG matrix. In contrast, drugs which had favorable interactions with PEG were incorporated into the interlamellar regions of the polymer up until the point at which the drug crystallized whereby phase separation occurred. These factors are likely to impact the effectiveness of drug/PEG systems as drug delivery systems.

  15. Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug–drug interaction induced by liver metabolites

    SciTech Connect (OSTI)

    Nakanishi, Takeo; Ikenaga, Miho; Fukuda, Hajime; Matsunaga, Norikazu; Tamai, Ikumi, E-mail: tamai@p.kanazawa-w.ac.jp

    2012-09-01T23:59:59.000Z

    We previously reported a quantitative time-lapse imaging (QTLI)-based analysis method to assess drug–drug interactions (DDI) at multidrug resistance-associated protein 2 (Mrp2) in rat sandwich-cultured hepatocyte (SCH) system, utilizing the fluorescent Mrp2 substrate, 5-(and 6)-carboxy-2?,7?-dichlorofluorescein (CDF). Here, we aimed to examine the feasibility of using QTLI to evaluate DDI involving drug metabolite(s) generated in hepatocytes. We used estradiol (E2) and bilirubin as model compounds; both are not substrates of MRP2, whereas their hepatic metabolites, estradiol-17?-glucuronide (E17G) or bilirubin glucuronides, are known to be its substrates as well as inhibitors. When rat SCHs were pre-exposed with E2, fluorescence of CDF accumulated in bile canaliculi decreased depending upon both the duration of pre-exposure and the concentration of extracellular E2. The decrease corresponded with the increase in intracellular concentration of E17G in hepatocytes. Furthermore, cytotoxicity of vinblastine, a substrate of MRP2, was enhanced in SCHs treated with E2. Similarly, CDF accumulated in bile canaliculi was significantly reduced in rat SCHs pre-exposed with bilirubin. In conclusion, these results suggest that phase II biotransformation of a competitor is reflected in alteration of MRP2-mediated CDF transport detected in QTLI. The QTLI might provide a convenient platform to evaluate transporter-based DDIs involving hepatic metabolites of drug candidates without the need to identify the metabolites. -- Highlights: ? Mrp2-mediated CDF transport is inhibited by E2, but not E17G in vesicle study. ? Both E2 and E17G do not compromise CDF formation from CDFDA in hepatocytes. ? CDF accumulation in bile canaliculi is inhibited by E2 or E17G in QTLI. ? Increasing exposure to E2 decreases CDF accumulation in bile canaliculi in QTLI. ? QTLI is feasible to assess Mrp2-based DDI involving drug metabolite in hepatocytes.

  16. Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http://www.robotic-lab.com/en/2011/04/22/nanotechnology-boosts-anticancer-drug-cocktail-many-times-over/[5/2/2011 12:11:22 PM

    E-Print Network [OSTI]

    Brinker, C. Jeffrey

    Robotic-Lab.COM » Nanotechnology boosts anticancer drug cocktail many times over http://www.robotic-lab.com/en/2011/04/22/nanotechnology-boosts-anticancer-drug-cocktail-many-times-over/[5/2/2011 12:11:22 PM] Nanotechnology boosts anticancer drug cocktail many times over Writte by Jim Lewis the 22/04/2011 Using

  17. Understanding the drivers of value creation for biopharmaceuticals around the time of drug launch

    E-Print Network [OSTI]

    You, Sung Min

    2012-01-01T23:59:59.000Z

    The purpose of this research is to investigate potential strategic variables that executives at small to mid-sized biopharmaceutical companies should consider during the period of a drug launch. Bringing a product to market ...

  18. drug discovery drug discovery

    E-Print Network [OSTI]

    drug discovery at Purdue #12;drug discovery 2 #12;drug discovery 3 Introduction The drug discovery and innovative drug candidates to treat chronic and acute illnesses. Our researchers also continue to be invested in various approaches to drug discovery, which include understanding of drug targets for future drug

  19. Boosting medicine with nanotechnology strengthens drug cocktail many times over http://www.nanowerk.com/news/newsid=21055.php[4/21/2011 11:18:27 AM

    E-Print Network [OSTI]

    Brinker, C. Jeffrey

    Boosting medicine with nanotechnology strengthens drug cocktail many times over http a report of consumers' views on the use of nanotechnology Posted: Apr 21st, 2011 Using niosomes: Apr 18th, 2011 Boosting medicine with nanotechnology strengthens drug cocktail many times over

  20. Optimal Sampling Times for a Drug and its Metabolite using SIMCYP Simulations as Prior Information

    E-Print Network [OSTI]

    Boyer, Edmond

    ; (ii) optimize the pharmacokinetic sampling times for an upcoming clinical study using a multi-response design approach, considering clinical constraints; and iii) evaluate the resulting design taking data

  1. Retention and switching kinetics of protonated gate field effect transistors

    SciTech Connect (OSTI)

    DEVINE,R.A.B.; HERRERA,GILBERT V.

    2000-05-23T23:59:59.000Z

    The switching and memory retention time has been measured in 50 {micro}m gatelength pseudo-non-volatile memory MOSFETS containing, protonated 40 nm gate oxides. Times of the order of 3.3 seconds are observed for fields of 3 MV cm{sup {minus}1}. The retention time with protons placed either at the gate oxide/substrate or gate oxide/gate electrode interfaces is found to better than 96{percent} after 5,000 seconds. Measurement of the time dependence of the source-drain current during switching provides clear evidence for the presence of dispersive proton transport through the gate oxide.

  2. Retention and Switching Kinetics of Protonated Gate Field Effect Transistors

    SciTech Connect (OSTI)

    DEVINE,R.A.B.; HERRERA,GILBERT V.

    2000-06-27T23:59:59.000Z

    The switching and memory retention time has been measured in 50 {micro}m gatelength pseudo-non-volatile memory MOSFETs containing, protonated 40 nm gate oxides. Times of the order of 3.3 seconds are observed for fields of 3 MV cm{sup {minus}1}. The retention time with protons placed either at the gate oxide/substrate or gate oxide/gate electrode interfaces is found to better than 96% after 5,000 seconds. Measurement of the time dependence of the source-drain current during switching provides clear evidence for the presence of dispersive proton transport through the gate oxide.

  3. Drug delivery by organ-specific immunoliposomes

    SciTech Connect (OSTI)

    Maruyama, Kazuo; Mori, Atsuhide; Hunag, Leaf (Tennessee Univ., Knoxville, TN (USA). Dept. of Biochemistry); Kennel, S.J. (Oak Ridge National Lab., TN (USA))

    1990-01-01T23:59:59.000Z

    Monoclonal antibodies highly specific to the mouse pulmonary endothelial cells were conjugated to liposomes. The resulting immunoliposomes showed high levels of lung accumulation when injected intravenously into mice. Optimal target binding and retention were achieved if the lipid composition included ganglioside GM{sub 1} to reduce the uptake of immunoliposomes by the reticuloendothelial system. Details of the construction and optimization of these organ-specific immunoliposomes are reviewed. The drug delivery potential of this novel liposome system was demonstrated in an experimental pulmonary metastasis model. Immunoliposomes containing a lipophilic prodrug of deoxyfluorouridine effectively prolonged the survival time of the tumor-bearing mice. This and other therapeutic applications of the immunoliposomes are discussed. 25 refs., 5 figs.

  4. Oxygen plasma immersion ion implantation treatment to enhance data retention of tungsten nanocrystal nonvolatile memory

    SciTech Connect (OSTI)

    Wang, Jer-Chyi, E-mail: jcwang@mail.cgu.edu.tw; Chang, Wei-Cheng; Lai, Chao-Sung, E-mail: cslai@mail.cgu.edu.tw [Department of Electronic Engineering, Chang Gung University, Kweishan 333, Taoyuan, Taiwan (China); Chang, Li-Chun [Department of Material Engineering and Center for Thin Film Technologies and Applications, Ming Chi University of Technology, Taishan 24301, New Taipei City, Taiwan (China); Ai, Chi-Fong; Tsai, Wen-Fa [Institute of Nuclear Energy Research, Atomic Energy Council, Longtan 325, Taoyuan, Taiwan (China)

    2014-03-15T23:59:59.000Z

    Data retention characteristics of tungsten nanocrystal (W-NC) memory devices using an oxygen plasma immersion ion implantation (PIII) treatment are investigated. With an increase of oxygen PIII bias voltage and treatment time, the capacitance–voltage hysteresis memory window is increased but the data retention characteristics become degraded. High-resolution transmission electron microscopy images show that this poor data retention is a result of plasma damage on the tunneling oxide layer, which can be prevented by lowering the bias voltage to 7?kV. In addition, by using the elevated temperature retention measurement technique, the effective charge trapping level of the WO{sub 3} film surrounding the W-NCs can be extracted. This measurement reveals that a higher oxygen PIII bias voltage and treatment time induces more shallow traps within the WO{sub 3} film, degrading the retention behavior of the W-NC memory.

  5. In vivo real-time monitoring system of electroporation mediated control of transdermal and topical drug delivery

    E-Print Network [OSTI]

    Ljubljana, University of

    ), doxorubicin (DOX) or fentanyl (FEN), were applied to the skin before and after EP. The new monitoring system as a positive control. The non-invasive monitoring of the delivery of DOX, a fluorescent chemotherapeutic drug the observed effects as obtained with FD and DOX, by the measured physiological responses of the mice as well

  6. Technetium Retention During LAW Vitrification

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2Uranium Transferon the PassingRouting TECFinish LineTaraTechnetium Retention

  7. Internal Combustion Engine Energy Retention (ICEER)

    Broader source: Energy.gov (indexed) [DOE]

    ICEER Internal Combustion Engine Energy Retention PI: Jeffrey Gonder Team: Eric Wood & Sean Lopp National Renewable Energy Laboratory June 18, 2014 Project ID: VSS126 This...

  8. Workforce Retention Work Group | Department of Energy

    Energy Savers [EERE]

    skilled workforce retention; health, safety and productivity; and especially preventive health care. Inform and support improvement andor development of wellness, fitness, and...

  9. Radionuclide Retention in Concrete Wasteforms

    SciTech Connect (OSTI)

    Wellman, Dawn M.; Jansik, Danielle P.; Golovich, Elizabeth C.; Cordova, Elsa A.

    2012-09-24T23:59:59.000Z

    Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how wasteform performance is affected by the full range of environmental conditions within the disposal facility; the process of wasteform aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of wasteform aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the wasteforms come in contact with groundwater. Data collected throughout the course of this work will be used to quantify the efficacy of concrete wasteforms, similar to those used in the disposal of LLW and MLLW, for the immobilization of key radionuclides (i.e., uranium, technetium, and iodine). Data collected will also be used to quantify the physical and chemical properties of the concrete affecting radionuclide retention.

  10. (WPI-iCeMS) Pure Nano Drugs*

    E-Print Network [OSTI]

    Takada, Shoji

    (WPI-iCeMS) SN-38 50 nm * Pure Nano Drugs* SN-38 10 HepG2* JST (-STEP Permeation and Retention (EPR)* EPR 20100 nm SN-38 SN-38 * SN-38 * SN-38 20 SN-38 Pure Nano Drugs

  11. Residential Refrigerator Recycling Ninth Year Retention Study

    E-Print Network [OSTI]

    Residential Refrigerator Recycling Ninth Year Retention Study Study ID Nos. 546B, 563 Prepared RECYCLING PROGRAMS Study ID Nos. 546B and 563 Prepared for Southern California Edison Rosemead, California

  12. Drug Trafficking Organizations and Counter-Drug Strategies in the U.S.-Mexican Context

    E-Print Network [OSTI]

    Astorga, Luis; Shirk, David A.

    2010-01-01T23:59:59.000Z

    Analytic Assessment of U.S. Drug Policy. Washington, D.C. ,K. (2008). Mexico Faces New Drug Challenge: Mini-Submarines.Mayors on Front Line of the Drug War. Los Angeles Times Los

  13. Deuterium Retention in NSTX with Lithium Conditioning

    SciTech Connect (OSTI)

    C.H. Skinner, J.P. Allain, W. Blanchard, H.W. Kugel, R. Maingi, L. Roquemore, V. Soukhanovskii, C.N. Taylor

    2010-06-02T23:59:59.000Z

    High (? 90%) deuterium retention was observed in NSTX gas balance measurements both withand without lithiumization of the carbon plasma facing components. The gas retained in ohmic discharges was measured by comparing the vessel pressure rise after a discharge to that of a gasonly pulse with the pumping valves closed. For neutral beam heated discharges the gas input and gas pumped by the NB cryopanels were tracked. The discharges were followed by outgassing of deuterium that reduced the retention. The relationship between retention and surface chemistry was explored with a new plasma-material interface probe connected to an in-vacuo surface science station that exposed four material samples to the plasma. XPS and TDS analysis showed that the binding of D atoms is fundamentally changed by lithium - in particular atoms are weakly bonded in regions near lithium atoms bound to either oxygen or the carbon matrix.

  14. High temperature ceramic composition for hydrogen retention

    DOE Patents [OSTI]

    Webb, R.W.

    1974-01-01T23:59:59.000Z

    A ceramic coating for H retention in fuel elements is described. The coating has relatively low thermal neutron cross section, is not readily reduced by H at 1500 deg F, is adherent to the fuel element base metal, and is stable at reactor operating temperatures. (JRD)

  15. California Institute of Technology Records Retention and Disposition Policy

    E-Print Network [OSTI]

    of the Records Retention and Disposition Policy is to establish and maintain a uniform records management policy activities and are subject to records management review and evaluation prior to any decisions regarding of Technology Records Retention Schedule ("Retention Schedule"). Department and division management should

  16. California Institute of Technology Records Retention and Disposition Policy

    E-Print Network [OSTI]

    Goddard III, William A.

    management policy for the control, retention, storage, retrieval, and disposal of recorded information, operations, or other activities and are subject to records management review and evaluation prior to any of Technology Records Retention Schedule ("Retention Schedule"). Department and division management should

  17. Drug delivery Combinatorial Drug Conjugation Enables Nanoparticle

    E-Print Network [OSTI]

    Zhang, Liangfang

    Drug delivery Combinatorial Drug Conjugation Enables Nanoparticle Dual-Drug Delivery Santosh Aryal, Che-Ming Jack Hu, and Liangfang Zhang* A new approach to loading multiple drugs onto the same drug through hydrolyzable linkers to form drug conjugates, is reported. In contrast to loading individual types

  18. PRIMARY RESEARCH PAPER Effects of travertine and flow on leaf retention

    E-Print Network [OSTI]

    Marks, Jane

    retention. Travertine, or calcium carbonate (CaCO3), is a mineral precipitate deposited when turbulence- induced CO2 out-gassing shifts the bicarbonate equilibrium, causing CaCO3 to deposit in the stream channel-fed, karst streams with supersaturated levels of CaCO3 (frequently 5­10 times saturation with respect

  19. Influence of plasticizer molecular weight on plasticizer retention in PVC geomembranes

    E-Print Network [OSTI]

    PROOFS Influence of plasticizer molecular weight on plasticizer retention in PVC geomembranes T. D, accepted 31 October 2004 ABSTRACT: Plasticizers are used to make PVC flexible so it can be used as a geomembrane. Plasticizers can migrate from PVC geomembranes over time because of contact with air, liquid, and

  20. Impact limiter retention using a tape joint

    SciTech Connect (OSTI)

    Gonzales, A.; Eakes, R.G.

    1986-01-01T23:59:59.000Z

    The Beneficial Uses Shipping System (BUSS) Cask employs polyurethane foam impact limiters that fit onto the ends of the cask. A foam impact limiter takes energy out of a system during a hypothetical accident condition by allowing foam crush and large deformations to occur. This, in turn, precludes high stresses or deformations from occurring to the cask. Because of the need to transmit significant amounts of heat to the environment, the BUSS cask impact limiters were designed to shield a minimum amount of the cask surface area. With this design impact limiter retention after the initial impact resulting from the 9 meter regulatory drops becomes a concern. Retention is essential to ensure the cask does not experience higher stresses during any secondary or rebound effects without impact limiters than it does during the 9 meter regulatory drop with impact limiters in place.

  1. 300 Area Building Retention Evaluation Mitigation Plan

    SciTech Connect (OSTI)

    D. J. McBride

    2007-07-03T23:59:59.000Z

    Evaluate the long-term retention of several facilities associated with the PNNL Capability Replacement Laboratory and other Hanfor mission needs. WCH prepared a mitigation plan for three scenarios with different release dates for specific buildings. The evaluations present a proposed plan for providing utility services to retained facilities in support of a long-term (+20 year) lifespan in addition to temporary services to buildings with specified delayed release dates.

  2. Competing retention pathways of uranium upon reaction with Fe...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    upon reaction with Fe(II). Abstract: Biogeochemical retention processes, including adsorption, reductive precipitation, and incorporation into host minerals, are important in...

  3. Radionuclide Retention in Concrete Wasteforms - FY13

    SciTech Connect (OSTI)

    Snyder, Michelle MV; Golovich, Elizabeth C.; Wellman, Dawn M.; Crum, Jarrod V.; Lapierre, Robert; Dage, Denomy C.; Parker, Kent E.; Cordova, Elsa A.

    2013-10-15T23:59:59.000Z

    Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how wasteform performance is affected by the full range of environmental conditions within the disposal facility; the process of wasteform aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of wasteform aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the wasteforms come in contact with groundwater. Data collected throughout the course of this work will be used to quantify the efficacy of concrete wasteforms, similar to those used in the disposal of low-level waste and mixed low-level waste, for the immobilization of key radionuclides (i.e., uranium, technetium, and iodine). Data collected will also be used to quantify the physical and chemical properties of the concrete affecting radionuclide retention.

  4. Radionuclide Retention in Concrete Waste Forms

    SciTech Connect (OSTI)

    Mattigod, Shas V.; Bovaird, Chase C.; Wellman, Dawn M.; Wood, Marcus I.

    2010-09-30T23:59:59.000Z

    Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how waste form performance is affected by the full range of environmental conditions within the disposal facility; the process of waste form aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of waste form aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the waste forms come in contact with groundwater. The information presented in the report provides data that 1) quantify radionuclide retention within concrete waste form materials similar to those used to encapsulate waste in the Low-Level Waste Burial Grounds (LLBG); 2) measure the effect of concrete waste form properties likely to influence radionuclide migration; and 3) quantify the stability of uranium-bearing solid phases of limited solubility in concrete.

  5. Retention of Halogens in Waste Glass

    SciTech Connect (OSTI)

    Hrma, Pavel R.

    2010-05-01T23:59:59.000Z

    In spite of their potential roles as melting rate accelerators and foam breakers, halogens are generally viewed as troublesome components for glass processing. Of five halogens, F, Cl, Br, I, and At, all but At may occur in nuclear waste. A nuclear waste feed may contain up to 10 g of F, 4 g of Cl, and ?100 mg of Br and I per kg of glass. The main concern is halogen volatility, producing hazardous fumes and particulates, and the radioactive iodine 129 isotope of 1.7x10^7-year half life. Because F and Cl are soluble in oxide glasses and tend to precipitate on cooling, they can be retained in the waste glass in the form of dissolved constituents or as dispersed crystalline inclusions. This report compiles known halogen-retention data in both high-level waste (HLW) and low-activity waste (LAW) glasses. Because of its radioactivity, the main focus is on I. Available data on F and Cl were compiled for comparison. Though Br is present in nuclear wastes, it is usually ignored; no data on Br retention were found.

  6. Cooking utensil with improved heat retention

    DOE Patents [OSTI]

    Potter, T.F.; Benson, D.K.; Burch, S.D.

    1997-07-01T23:59:59.000Z

    A cooking utensil with improved heat retention includes an inner pot received within an outer pot and separated in a closely spaced-apart relationship to form a volume or chamber there between. The chamber is evacuated and sealed with foil leaves at the upper edges of the inner and outer pot. The vacuum created between the inner and outer pot, along with the minimum of thermal contact between the inner and outer pot, and the reduced radiative heat transfer due to low emissivity coatings on the inner and outer pot, provide for a highly insulated cooking utensil. Any combination of a plurality of mechanisms for selectively disabling and re-enabling the insulating properties of the pot are provided within the chamber. These mechanisms may include: a hydrogen gas producing and reabsorbing device such as a metal hydride, a plurality of metal contacts which can be adjusted to bridge the gap between the inner and outer pot, and a plurality of bimetallic switches which can selectively bridge the gap between the inner and outer pot. In addition, phase change materials with superior heat retention characteristics may be provided within the cooking utensil. Further, automatic and programmable control of the cooking utensil can be provided through a microprocessor and associated hardware for controlling the vacuum disable/enable mechanisms to automatically cook and save food. 26 figs.

  7. Cooking utensil with improved heat retention

    DOE Patents [OSTI]

    Potter, Thomas F. (Denver, CO); Benson, David K. (Golden, CO); Burch, Steven D. (Golden, CO)

    1997-01-01T23:59:59.000Z

    A cooking utensil with improved heat retention includes an inner pot received within an outer pot and separated in a closely spaced-apart relationship to form a volume or chamber therebetween. The chamber is evacuated and sealed with foil leaves at the upper edges of the inner and outer pot. The vacuum created between the inner and outer pot, along with the minimum of thermal contact between the inner and outer pot, and the reduced radiative heat transfer due to low emissivity coatings on the inner and outer pot, provide for a highly insulated cooking utensil. Any combination of a plurality of mechanisms for selectively disabling and re-enabling the insulating properties of the pot are provided within the chamber. These mechanisms may include: a hydrogen gas producing and reabsorbing device such as a metal hydride, a plurality of metal contacts which can be adjusted to bridge the gap between the inner and outer pot, and a plurality of bimetallic switches which can selectively bridge the gap between the inner and outer pot. In addition, phase change materials with superior heat retention characteristics may be provided within the cooking utensil. Further, automatic and programmable control of the cooking utensil can be provided through a microprocessor and associated hardware for controlling the vacuum disable/enable mechanisms to automatically cook and save food.

  8. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01T23:59:59.000Z

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  9. CLINICAL RETENTION EXPECTATIONS AND UNLV ATHLETIC TRAINING PROGRAM

    E-Print Network [OSTI]

    Hemmers, Oliver

    CLINICAL RETENTION EXPECTATIONS AND STANDARDS UNLV ATHLETIC TRAINING PROGRAM The Program Director and Clinical Education Coordinator will evaluate retention in the Athletic Training Program. Athletic training, the athletic training student will be permitted to take the scheduled SIM clinical course and will be given

  10. 207-A retention basins system design description

    SciTech Connect (OSTI)

    Wahlquist, R.A.

    1994-09-29T23:59:59.000Z

    The 242-A Evaporator is a waste treatment facility designed to reduce liquid waste volumes currently stored in the Hanford Area double shell Waste Storage Tanks. The evaporator uses evaporative concentration to achieve this volume reduction, returning the concentrated slurry to the double-shell tanks for storage. The process effluent is transferred to various retention/treatment facilities for eventual release to the environment. The process utilizes an evaporator vessel and various supporting systems for heating, evaporating, and condensing low-heat-generating liquid waste produced it the Hanford Site. The process reduces the total volume of the liquid waste requiring storage in a double shell tank, making it more manageable for current storage as well as for future treatment and disposal. The main components of the 242-A Evaporator are the Reboiler, Vapor-Liquid Separator, Recirculation Pump and Pump Loop, Slurry System, Condenser System, Steam Jet Vacuum System, Condensate Collection Tank, and Ion Exchange System.

  11. Running heading: Water retention properties of the clay in clayey soils Water retention properties of the clay in soils developed

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Running heading: Water retention properties of the clay in clayey soils Water retention properties of the clay in soils developed on clayey sediments: Significance of parent material and soil of clayey subsoils horizons according to the variation of clay characteristics. The horizons studied

  12. Drug Overdose Deaths, Hospitalizations,

    E-Print Network [OSTI]

    MacAdam, Keith

    Drug Overdose Deaths, Hospitalizations, and Emergency Department Visits in Kentucky, 2000 - 2012 #12; Kentucky Injury Preven on and Research Center Drug Overdose Deaths, Hospitaliza ons . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Drug overdose deaths, 20002012

  13. EUROPIUM RETENTION ONTO CLAY MINERALS FROM 25 TO 150C: EXPERIMENTAL MEASUREMENTS, SPECTROSCOPIC FEATURES AND SORPTION MODELLING.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 EUROPIUM RETENTION ONTO CLAY MINERALS FROM 25 TO 150°C: EXPERIMENTAL MEASUREMENTS, SPECTROSCOPIC.Tertre@univ-lille1.fr Keywords: europium, sorption, clays, experimental, temperature, Time-Resolved Laser was investigated up to 150°C. The clays were purified samples, saturated with Na in the case of montmorillonite

  14. Formation and retention of methane in coal

    SciTech Connect (OSTI)

    Hucka, V.J.; Bodily, D.M.; Huang, H.

    1992-05-15T23:59:59.000Z

    The formation and retention of methane in coalbeds was studied for ten Utah coal samples, one Colorado coal sample and eight coal samples from the Argonne Premium Coal Sample Bank.Methane gas content of the Utah and Colorado coals varied from zero to 9 cm{sup 3}/g. The Utah coals were all high volatile bituminous coals. The Colorado coal was a gassy medium volatile bituminous coal. The Argonne coals cover a range or rank from lignite to low volatile bituminous coal and were used to determine the effect of rank in laboratory studies. The methane content of six selected Utah coal seams and the Colorado coal seam was measured in situ using a special sample collection device and a bubble desorbometer. Coal samples were collected at each measurement site for laboratory analysis. The cleat and joint system was evaluated for the coal and surrounding rocks and geological conditions were noted. Permeability measurements were performed on selected samples and all samples were analyzed for proximate and ultimate analysis, petrographic analysis, {sup 13}C NMR dipolar-dephasing spectroscopy, and density analysis. The observed methane adsorption behavior was correlated with the chemical structure and physical properties of the coals.

  15. Retention of Nursing Faculty: Associate Degree Administrators' Perspectives

    E-Print Network [OSTI]

    Harris, Jennifer

    2014-08-31T23:59:59.000Z

    Retention of faculty is a complex and dynamic challenge for nursing education. Nursing is facing the growing dilemma of a shrinking population of current nursing faculty (AACN, 2012; Banks, 2012; Evans, 2013, & Proto & ...

  16. Segmented vs conventional numerals: legibility and long term retention

    E-Print Network [OSTI]

    Hill, Steve Edgar

    1971-01-01T23:59:59.000Z

    SEGMENTED VS CONVENTIONAL NUMERALS: LEGIBILITY AND LONG TERM RETENTION A Thesis by STEVE EDGAR HILL Submitted to the Graduate College of Texas A8cM University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE... December 1971 Ma]or Subject: Industrial Engineering SEGMENTED VS CONVENTIONAL NUMERALS: LEGIBILITY AND LONG TERM RETENTION A Thesis STEVE EDGAR HILL Approved as to style and content by: Elias Chairman of Committee) r. A. W. ortham (Head...

  17. Pilot-Scale Benzene Retention and Release Demonstration

    SciTech Connect (OSTI)

    Marek, J.C.

    2003-11-10T23:59:59.000Z

    During the initial months of In-Tank Precipitation radioactive operation in 1995 the process experienced high rates of tetraphenylborate decomposition with assumed corresponding high rates of benzene generation. In March 1996 after a two month quiescent period, a water addition to Tank 48H resulted in an unexpected benzene release to the tank vapor phase. This was the first time a low energy input resulted in a significant release rate. This led to questions about how benzene, generated in-situ by TPB decomposition, was retained in the surrounding potassium tetraphenylborate slurry. It was postulated the retention mechanism may have changed during the quiescent period prior to March so the benzene present became readily releasable to the vapor phase with low energy input to the slurry or that enough benzene accumulated that some of it was in a different, more releasable form. Readily releasable is a qualitative term defined as a rapid release of benzene at a rate approaching evaporation of a free benzene layer. It is intended to distinguish between benzene in a form with high liquid phase resistance to mass transfer diffusion controlled from benzene in a form with minimal liquid phase resistance to mass transfer free benzene layer evaporation. If a readily releasable form of benzene was present, the vapor space profile during release tests was anticipated to have an initial benzene vapor space concentration peak followed by a lower vapor concentration, longer duration release.

  18. Oral Drug Absorption

    E-Print Network [OSTI]

    Yamashita, Shinji

    2006-10-26T23:59:59.000Z

    properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

  19. Liquid Effluent Retention Facility (LERF) Final Hazard Category Determination

    SciTech Connect (OSTI)

    HUTH, L.L.

    2001-06-06T23:59:59.000Z

    The Liquid Effluent Retention Facility was designed to store 242-A Evaporator process condensate and other liquid waste streams for treatment at the 200 East Area Effluent Treatment Facility. The Liquid Effluent Retention Facility has been previously classified as a Category 3 Nonreactor Nuclear Facility. As defined in Hazard Categorization and Accident Analysis Techniques for Compliance with DOE Order 5480.23, Nuclear Safety Analysis Reports (DOE 1992, DOE 1997), Category 3 Nuclear Facilities have the potential for significant localized (radiological) consequences. However, based on current facility design, operations, and radioactive constituent concentrations, the Liquid Effluent Retention Facility does not have the potential for significant localized (radiological) consequences and is categorized as a Radiological Facility. This report documents the final hazard categorization process performed in accordance with DOE Order 5480.23, Nuclear Safety Analysis Reports. This report describes the current configuration and operations of the Liquid Effluent Retention Facility. Also included is a preliminary hazard categorization, which is based on current and proposed radioactive and hazardous material inventories, a preliminary hazards and accident analysis, and a final hazard category determination. The results of the hazards and accident analysis, based on the current configuration and operations of the Liquid Effluent Retention Facility and the current and proposed radioactive and hazardous material inventories, demonstrate that the Liquid Effluent Retention Facility does not have the potential for significant localized (radiological) consequences. Based on the final hazard category analysis, the Liquid Effluent Retention Facility is a Radiological Facility. The final hazard category determination is based on a comparative evaluation of the consequence basis for the Category 3 threshold quantities to the calculated consequences for credible releases The basis for the Category 3 threshold quantities is 10 rem-equivalent man at 30 meters (98 feet) (DOE 1992, DOE 1997). The calculated 12 hour consequences to an individual located at 30 meters (98 feet) for two credible scenarios, spray release and a pool release, are 3.50 rem and 1.32 rem, respectively, which based upon the original hazard categorization criteria (DOE 1992) classified the Liquid Effluent Retention Facility as a Radiological Facility. Comparison of the calculated 24 hour consequences to an individual located at 30 meters (98 feet) for two credible scenarios, spray release and a pool release, 7.00 rem and 2.64 rem respectively, confirmed the Liquid Effluent Retention Facility classification as a Radiological Facility under the current hazard categorization criteria (DOE 1997). Both result in dose consequence values less than the allowable, 10 rem, meeting the requirements for categorizing the Liquid Effluent Retention Facility as a Radiological Facility.

  20. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance

    E-Print Network [OSTI]

    Clairambault, Jean

    period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

  1. OFWAR: Reducing SSD Response Time Using On-Demand Fast-Write-and-Rewrite

    E-Print Network [OSTI]

    Zhang, Tong

    OFWAR: Reducing SSD Response Time Using On-Demand Fast-Write-and-Rewrite Qi Wu and Tong Zhang to degrade SSD response time, we speed up memory programming at the penalty of shorter data retention time the average SSD response time by up to 52.3%. Index Terms--Solid-state drive, data retention, workload

  2. Retention of Tracer Gas from Instantaneous Releases of SF6 in an Urban Environment

    SciTech Connect (OSTI)

    Doran, J. C.; Allwine, K Jerry; Clawson, Kirk L.; Carter, Roger G.

    2006-01-01T23:59:59.000Z

    Data from a series of instantaneous releases of SF6 tracer during the Joint Urban 2003 study in Oklahoma City have been analyzed to determine characteristic retention times for puffs in an urban environment. Results from nine real-time tracer detectors with a time response of 0.5 seconds were used in the analysis. Distances from the source ranged from less than 200 m to over 1 km. For each individual intensive operating period (IOP), the detector locations were adjusted so that, given the expected wind directions during the releases, the detectors would lie generally downwind of the release point. As a result, building characteristics upwind of the detectors varied from one IOP to the next. Animations of the tracer concentrations show clear evidence of channeling along street canyons approximately parallel to the prevailing wind directions, trapping in street canyons perpendicular to the flow, and other complex circulation patterns. Retention times for individual puffs ranged from a few minutes to over 20 minutes, with a strong mode in the distribution around 11 minutes. There was surprisingly little correlation with wind speed or direction. Comparisons with simple puff models are presented.

  3. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01T23:59:59.000Z

    and the risk of illicit drug use: the Adverse Childhoodalcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.

  4. Nanotechnology Now -Press Release: "Sandia and UNM lead effort to destroy cancers: Boosting medicine with nanotechnology strengthens drug cocktail many times over" http://www.nanotech-now.com/news.cgi?story_id=42258[4/21/2011 11:23:41 AM

    E-Print Network [OSTI]

    Brinker, C. Jeffrey

    Nanotechnology Now - Press Release: "Sandia and UNM lead effort to destroy cancers: Boosting medicine with nanotechnology strengthens drug cocktail many times over" http://www.nanotech-now.com/news.cgi?story_id=42258[4/21/2011 11:23:41 AM] About Us Nanotechnology News Columns Products Directories Career Center

  5. Faculty Retention and Gender Adrienne Kertzer and Jenny Godley

    E-Print Network [OSTI]

    Calgary, University of

    1 Faculty Retention and Gender Adrienne Kertzer and Jenny Godley Advisory Committee on the Status, and home faculty; by year, rank, and total number of faculty members across the 1 E-mail Adrienne Kertzer, and total number of faculty members in the home faculty.3 In January 2013, Jenny Godley, Department

  6. Evolutionary Computing for Detection of Retentive Structures in Coastal Waters

    E-Print Network [OSTI]

    Fernandez, Thomas

    ,robillia,poty,fonlupt}@lil.univ-littoral.fr, Abstract-- The demography of anchovy fishes in the Gulf of Biscay seems to be related to the presence of so- called "retentive" hydrodynamical structures, that keep fish eggs and larvae in a favorable environment be used to decide fishing quotas or bans for the sake of preserving the natural resource. We propose two

  7. Predicting Student Retention and Academic Success at New Mexico Tech

    E-Print Network [OSTI]

    Borchers, Brian

    Predicting Student Retention and Academic Success at New Mexico Tech by Julie Luna Submitted Research and Statistics Option New Mexico Institute of Mining and Technology Socorro, New Mexico August at the New Mexico Institute of Mining and Technology. Joe Franklin of the Information Services Department

  8. Techniques and Technology Article Optimizing Radio Retention and Minimizing Radio

    E-Print Network [OSTI]

    Sandercock, Brett K.

    Techniques and Technology Article Optimizing Radio Retention and Minimizing Radio Impacts the duration of transmitter attachment and minimizing the impacts of radios on the behavior and demography of the study animal. We tested 4 methods of radio attachment for a breeding population of upland sandpipers

  9. Guidelines for the Management and Retention of Public Record

    E-Print Network [OSTI]

    Sheridan, Jennifer

    v1.2 1 11/23/2010 Guidelines for the Management and Retention of Public Record E-Mail Wisconsin Public Records Board #12;v1.2 2 11/23/2010 Contents Introduction .............................................................................................................................3 Determine if you have a public record

  10. ORIGINAL PAPER Argon retention properties of silicate glasses and implications

    E-Print Network [OSTI]

    Harrison, Mark

    data from rocks depends on many factors, knowing the Ar transport properties of any dated materialORIGINAL PAPER Argon retention properties of silicate glasses and implications for 40 Ar/39 Ar age fused from igneous-derived cohesive fault rock and igneous rock, and step-heated from $400 to >1,200 °C

  11. Retention of ferrite in AluminiumAlloyed TRIPassisted steels

    E-Print Network [OSTI]

    Cambridge, University of

    Retention of ­ferrite in Aluminium­Alloyed TRIP­assisted steels Young Joo Choi1, Dong­Woo Suh1 properties (Yi et al., 2011a). It is known in this context, that alloying with aluminium makes the ­phase), thus necessitating the empirical study of a series of seven alloys with varying aluminium contents

  12. Arsenate and Chromate Retention Mechanisms on Goethite. 1.

    E-Print Network [OSTI]

    Sparks, Donald L.

    Research Arsenate and Chromate Retention Mechanisms on Goethite. 1. Surface Structure S C O T T F E environment of two environmental contaminants, arsenate and chromate, on the mineral goethite (R-FeOOH). Based on the oxyanion- Fe distances, it was concluded that three different surface complexes exist on goethite for both

  13. Arsenate and Chromate Retention Mechanisms on Goethite. 2.

    E-Print Network [OSTI]

    Sparks, Donald L.

    Arsenate and Chromate Retention Mechanisms on Goethite. 2. Kinetic Evaluation Using a Pressure on goethite (R-FeOOH) were investigated using apressure-jump(p-jump)relaxationtechnique. Information provided. The adsorption/desorption of these oxyanions on goethite involved a double relaxation event. The proposed

  14. PLASTICIZER RETENTION IN PVC GEOMEMBRANES T. D. Stark1

    E-Print Network [OSTI]

    1 PLASTICIZER RETENTION IN PVC GEOMEMBRANES T. D. Stark1 , H. Choi2 , and P. W. Diebel3 1, Ontario, Canada, N1R 5T6; PH (519)623-1630; email: PDiebel@cgtower.com ABSTRACT: Plasticizers are used to make PVC flexible so it can be used as a geomembrane for containment purposes. Plasticizers can migrate

  15. Offering Sign-On and Retention Bonus Payments to Faculty March 12, 2012

    E-Print Network [OSTI]

    Acton, Scott

    Offering Sign-On and Retention Bonus Payments to Faculty March 12, 2012 page 1 Policy on Offering Sign-On and Retention Bonus Payments to Faculty Date: March 12, 2012 Policy ID: 1.600 Status: Final for Policy: This policy was developed to clarify the approval required to offer a sign ­on or retention bonus

  16. Environmental effects of dredging. Documentation of the dyecon module for ADDAMS: Determining the hydraulic retention and efficiency of confined disposal facilities. Technical note

    SciTech Connect (OSTI)

    Hayes, D.F.; Schroeder, P.R.; Engler, R.M.; Patin, T.R.

    1992-12-01T23:59:59.000Z

    This technical note describes procedures for determining mean hydraulic retention time and efficiency of a confined disposal facility (CDF) from a dye tracer slug test. These parameters are required to properly design a CDF for solids retention and for effluent quality considerations. Detailed information on conduct and analysis of dye tracer studies can be found in Engineer Manual 1110-2-5027, Confined Dredged Material Disposal. This technical note documents the DYECON computer program which facilitates the analysis of dye tracer concentration data and computes the hydraulic efficiency of a CDF as part of the Automated Dredging and Disposal Alternatives Management System (ADDAMS).

  17. Chemoinformatics in drug development

    E-Print Network [OSTI]

    2012-05-01T23:59:59.000Z

    ORAL PRESENTATION Open Access Chemoinformatics in drug development Colin R Groom From 7th German Conference on Chemoinformatics: 25 CIC-Workshop Goslar, Germany. 6-8 November 2011 It would be unimaginable to prosecute a drug discovery program... to the contributions that can be made as a candidate molecule progresses towards becoming part of a drug substance. This presentation will highlight the opportunities for the application of chemoinformatics techniques to the area of pharmaceutical materials science, a...

  18. Environmental measurement-while-drilling-gamma ray spectrometer (EMWD-GRS) system technology demonstration plan for use at the Savannah River Site F-Area Retention Basin

    SciTech Connect (OSTI)

    Williams, C.V.; Lockwood, G.J.; Normann, R.A. [Sandia National Labs., Albuquerque, NM (United States)] [Sandia National Labs., Albuquerque, NM (United States); Gruebel, R.D. [Tech Reps, Inc., Albuquerque, NM (United States)] [Tech Reps, Inc., Albuquerque, NM (United States)

    1996-08-01T23:59:59.000Z

    The Environmental Measurement-While-Drilling-Gamma Ray Spectrometer (EMWD-GRS) system represents an innovative blend of new and existing technology that provides the capability of producing real-time environmental and drillbit data during drilling operations. This demonstration plan presents information on the EMWD-GRS technology, demonstration design, Cs-137 contamination at the Savannah River Site F-Area Retention Basin, responsibilities of demonstration participants, and the policies and procedures for the demonstration to be conducted at the Savannah River Site F-Area Retention Basin. The EMWD-GRS technology demonstration will consist of continuously monitoring for gamma-radiation contamination while drilling two horizontal boreholes below the backfilled retention basin. These boreholes will pass near previously sampled vertical borehole locations where concentrations of contaminant levels are known. Contaminant levels continuously recorded by the EMWD-GRS system during drilling will be compared to contaminant levels previously determined through quantitative laboratory analysis of soil samples.

  19. Nanoparticle drug delivery enhances the cytotoxicity of hydrophobichydrophilic drug conjugates

    E-Print Network [OSTI]

    Zhang, Liangfang

    Nanoparticle drug delivery enhances the cytotoxicity of hydrophobic­hydrophilic drug conjugates, Accepted 4th October 2011 DOI: 10.1039/c1jm13834k We report a drug conjugation approach to concurrently load both hydrophobic and hydrophilic drugs into the same drug delivery nanocarrier in a precisely

  20. Sulfate Retention and Segregation in Simulated Radioactive Waste Borosilicate Glasses

    SciTech Connect (OSTI)

    Li, Hong; Hrma, Pavel R.; Vienna, John D.

    2000-04-19T23:59:59.000Z

    Sulfate segregation from processing radioactive waste glasses causes an acceleration of the melter refractory corrosion and partitioning of radionuclides in the segregated layer. A sulfate retention (SR)-composition relationship has been established for various simulated high-level and low-activity waste glass compositions in terms of the relative non-bridging oxygen (NBO) concentration in the melt. Phosphate was found to significantly increase sulfate retention. However, the correlation between SR and NBO could not explain the sulfate segregation tendency. For instance, glasses with a higher ratio of boron to sodium suppress sulfate segreation in the melt in which SR is expected to be lower. As sulfate segregation is a kinetic process, occurring in the batch to glass conversion process, initial reactions of the batch materials are considered to have stronger effects on the sulfate segregation tendency, pointing out the need to study the impact of batch materials on sulfate segregation.

  1. Average Soil Water Retention Curves Measured by Neutron Radiography

    SciTech Connect (OSTI)

    Cheng, Chu-Lin [ORNL; Perfect, Edmund [University of Tennessee, Knoxville (UTK); Kang, Misun [ORNL; Voisin, Sophie [ORNL; Bilheux, Hassina Z [ORNL; Horita, Juske [Texas Tech University (TTU); Hussey, Dan [NIST Center for Neutron Research (NCRN), Gaithersburg, MD

    2011-01-01T23:59:59.000Z

    Water retention curves are essential for understanding the hydrologic behavior of partially-saturated porous media and modeling flow transport processes within the vadose zone. In this paper we report direct measurements of the main drying and wetting branches of the average water retention function obtained using 2-dimensional neutron radiography. Flint sand columns were saturated with water and then drained under quasi-equilibrium conditions using a hanging water column setup. Digital images (2048 x 2048 pixels) of the transmitted flux of neutrons were acquired at each imposed matric potential (~10-15 matric potential values per experiment) at the NCNR BT-2 neutron imaging beam line. Volumetric water contents were calculated on a pixel by pixel basis using Beer-Lambert s law after taking into account beam hardening and geometric corrections. To remove scattering effects at high water contents the volumetric water contents were normalized (to give relative saturations) by dividing the drying and wetting sequences of images by the images obtained at saturation and satiation, respectively. The resulting pixel values were then averaged and combined with information on the imposed basal matric potentials to give average water retention curves. The average relative saturations obtained by neutron radiography showed an approximate one-to-one relationship with the average values measured volumetrically using the hanging water column setup. There were no significant differences (at p < 0.05) between the parameters of the van Genuchten equation fitted to the average neutron radiography data and those estimated from replicated hanging water column data. Our results indicate that neutron imaging is a very effective tool for quantifying the average water retention curve.

  2. Drug delivery Sustained Drug Release from Non-eroding Nanoporous

    E-Print Network [OSTI]

    Sridhar, Srinivas

    drug, doxorubicin (Dox), from different non-eroding nanopor- ous coatings. Detailed studies of drug, in the case of small molecules such as Dox, enzymes would not interfere with the drug and hence the elution

  3. Fixed drug eruption caused by the Japanese herbal drug kakkonto

    E-Print Network [OSTI]

    Furuichi, Megumi; Hara, Hiroshi; Asano, Yukie; Makino, Teruhiko; Shimizu, Tadamichi

    2010-01-01T23:59:59.000Z

    Topical provocation of fixed drug eruption. Br J Dermatol.neglected offender for fixed drug eruptions. Eur J Dermatoloral and non-oral herbal drugs may cause FDE. References 1.

  4. Drug Use and Drug Policy in a Prohibition Regime

    E-Print Network [OSTI]

    MacCoun, Robert; Martin, Karin D.

    2008-01-01T23:59:59.000Z

    Prisoners (prior to offense), Drug-related Emergency RoomVisits, 2007 DAWN All illicit drugs Marijuana Cocaine Crack2/4/2008 - 41 Other Sentence Drug Sentence Federal Prisoners

  5. A Decentralized Public Key Infrastructure with Identity Retention Conner Fromknecht (conner@mit.edu), Dragos Velicanu (velicanu@mit.edu),

    E-Print Network [OSTI]

    provided by cryptocurrencies such as Bitcoin and Namecoin to build a PKI that ensures identity retention

  6. Chapter 3.5: Freshman Undergraduate Retention1 Improve retention and graduation rates for all first-year engineering undergraduate students,

    E-Print Network [OSTI]

    Chapter 3.5: Freshman Undergraduate Retention1 Objective Improve retention and graduation rates graduation rate for transfer student. Strategies 1. Develop a program that continuously improves the delivery pass/fail efforts, either continue or adopt best practices form project for long-term implementation. 2

  7. Noninvasive quantification of drug delivery from an implantable MEMS device

    E-Print Network [OSTI]

    Johnson, Audrey M., 1976-

    2005-01-01T23:59:59.000Z

    (cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

  8. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01T23:59:59.000Z

    alcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.outcomes in an indicated drug prevention program for high-

  9. Anticoagulation Drug Therapy: A Review

    E-Print Network [OSTI]

    Harter, Katherine; Levine, Michael; Henderson, Sean O.

    2015-01-01T23:59:59.000Z

    et al. Anticoagulation Drug Therapy: A Review 15. NishijimaRandomized antiplatelet drugs. In: Goodman & Gilman’s The2008;24:2757-65. Cardiovasc Drugs. 2006;6:265-85. 34. Nordt

  10. Drug Information Chart Notes Drug ad (intrinsic bias)

    E-Print Network [OSTI]

    Abolmaesumi, Purang

    Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company Dosage Same or different? A drug in a different dosage can be used for a different therapy. Precautions Check for pregnancy A complete book on drugs in pregnancy and lactation in bibliography. (unbiased

  11. Chemical signatures and new drug targets for gametocytocidal drug

    E-Print Network [OSTI]

    Arnold, Jonathan

    Chemical signatures and new drug targets for gametocytocidal drug development Wei Sun1 *, Takeshi Q antimalarial drugs are not active against P. falciparum gametocytes, responsible for the spread of malaria screening 5,215 known drugs and compounds. All these compounds were active against three strains

  12. Intake retention functions and derived investigation levels for selected radioelements

    E-Print Network [OSTI]

    Buitron Sanchez, Susana

    1990-01-01T23:59:59.000Z

    of these metabolic processes as well as those that occur in all compartments that feed the systemic circulation. 16 INHALATION I INGESTION ST (1) SI (2) ULI (3) j j LYMPH NODES UPTAKE LLI (4) 1S 2S . . . . iS . " nS F f WOUND E SYSTEMIC EXCRETION 1-F..., Sr. (Chair of Committee) Milton . McLain (Member) Wesl E. Bolch (Member) Dan ightower (Member) ohn W. oston, Sr (Department Head) August 1990 ABSTRACT Intake Retention Functions and Derived Investigation Levels for Selected Radioelements...

  13. Nuclear reactor melt-retention structure to mitigate direct containment heating

    DOE Patents [OSTI]

    Tutu, Narinder K. (Manorville, NY); Ginsberg, Theodore (East Setauket, NY); Klages, John R. (Mattituck, NY)

    1991-01-01T23:59:59.000Z

    A light water nuclear reactor melt-retention structure to mitigate the extent of direct containment heating of the reactor containment building. The structure includes a retention chamber for retaining molten core material away from the upper regions of the reactor containment building when a severe accident causes the bottom of the pressure vessel of the reactor to fail and discharge such molten material under high pressure through the reactor cavity into the retention chamber. In combination with the melt-retention chamber there is provided a passageway that includes molten core droplet deflector vanes and has gas vent means in its upper surface, which means are operable to deflect molten core droplets into the retention chamber while allowing high pressure steam and gases to be vented into the upper regions of the containment building. A plurality of platforms are mounted within the passageway and the melt-retention structure to direct the flow of molten core material and help retain it within the melt-retention chamber. In addition, ribs are mounted at spaced positions on the floor of the melt-retention chamber, and grid means are positioned at the entrance side of the retention chamber. The grid means develop gas back pressure that helps separate the molten core droplets from discharged high pressure steam and gases, thereby forcing the steam and gases to vent into the upper regions of the reactor containment building.

  14. Hamerschlag Hall Green Roof Storm Water Retention and Runoff Reduction Performance Lucheng Chen

    E-Print Network [OSTI]

    Andrews, Peter B.

    Hamerschlag Hall Green Roof Storm Water Retention and Runoff Reduction Performance ......................................................................................................................... 2 2. Hamerschlag Hall Green Roof .............................................................................. 13 4. Methods of Storm Analysis and Green Roof Performance Analysis

  15. Local coordination of Zn in hydroxy-interlayered minerals and implications for Zn retention in soils

    E-Print Network [OSTI]

    -interlayered minerals (HIM) for Zn retention in contaminated soils. Published and newly collected extended XLocal coordination of Zn in hydroxy-interlayered minerals and implications for Zn retention. In a second part, we determined the spe- ciation of Zn in eight contaminated soils (251­1039 mg/kg Zn

  16. UNC Tomorrow Phase II Campus Response Faculty and Staff Recruitment and Retention

    E-Print Network [OSTI]

    1 UNC Tomorrow Phase II Campus Response Faculty and Staff Recruitment and Retention Submitted to/Tenure Track Faculty Hires 2009-2017 #12; 4 The projected demand for faculty and EPA and SPA staff create a range of implications for recruitment and retention in academic and non- academic units. The most

  17. PPPL-3311, Preprint: August 1998, UC-420, 423 Modeling of Tritium Retention in TFTR*

    E-Print Network [OSTI]

    - 1 - PPPL-3311, Preprint: August 1998, UC-420, 423 Modeling of Tritium Retention in TFTR* C Fusion Test Reactor tritium retention experience is reviewed and the data related to models of plasma surface interactions. Over 3.5 years of TFTR DT operations, approximately 51% of the tritium injected

  18. Retention of Butt-End Aluminum Leg Bands by Wild Turkeys

    E-Print Network [OSTI]

    Butler, Matthew J.

    Note Retention of Butt-End Aluminum Leg Bands by Wild Turkeys MATTHEW J. BUTLER,1,2 Department wild turkeys (Meleagris gallopavo intermedia) captured in Texas and Kansas, USA, 2000­2009. We examined 187 recaptured or harvested radiotagged wild turkeys to determine band retention and modeled band

  19. RETENTION OF SULFATE IN HIGH LEVEL RADIOACTIVE WASTE GLASS

    SciTech Connect (OSTI)

    Fox, K.

    2010-09-07T23:59:59.000Z

    High level radioactive wastes are being vitrified at the Savannah River Site for long term disposal. Many of the wastes contain sulfate at concentrations that can be difficult to retain in borosilicate glass. This study involves efforts to optimize the composition of a glass frit for combination with the waste to improve sulfate retention while meeting other process and product performance constraints. The fabrication and characterization of several series of simulated waste glasses are described. The experiments are detailed chronologically, to provide insight into part of the engineering studies used in developing frit compositions for an operating high level waste vitrification facility. The results lead to the recommendation of a specific frit composition and a concentration limit for sulfate in the glass for the next batch of sludge to be processed at Savannah River.

  20. Deuterium Retention in Beryllium Exposed to a 60kV Deuterium Beam ­ Consequences for Next Step Devices

    E-Print Network [OSTI]

    Deuterium Retention in Beryllium Exposed to a 60kV Deuterium Beam ­ Consequences for Next Step Devices

  1. Essays on Drug Use and Crime

    E-Print Network [OSTI]

    Deza, Monica

    2012-01-01T23:59:59.000Z

    Prinz. A. , 1997, Do European drugs policies mater? Economicruin? Sequences of initiation to drugs and crime in Britain.and P. Grimes, 2001, Adolescent Drug Use and Educational

  2. Annu. Rev. Med. 2002. 53:595614 RATIONAL APPROACH TO AIDS DRUG DESIGN

    E-Print Network [OSTI]

    Annu. Rev. Med. 2002. 53:595­614 RATIONAL APPROACH TO AIDS DRUG DESIGN THROUGH STRUCTURAL BIOLOGY than a dozen drugs in the past 15 years for the treatment of AIDS offer an excellent example of progress in the field of rational drug design. At this time, the principal targets are reverse

  3. USC Drug-Free Prevention, education and counseling services along with university

    E-Print Network [OSTI]

    Southern California, University of

    USC Drug-Free Prevention, education and counseling services along with university policies and procedures for preserving a drug-free workplace and study environment A message from President C. L. Max, and other drugs. Academic life can be stressful at times. Students often feel the weight of the goal

  4. Quantification of absorption, retention and elimination of two different oral doses of vitamin A in Zambian boys using accelerator mass spectrometry

    SciTech Connect (OSTI)

    Aklamati, E K; Mulenga, M; Dueker, S R; Buchholz, B A; Peerson, J M; Kafwembe, E; Brown, K H; Haskell, M J

    2009-10-12T23:59:59.000Z

    A recent survey indicated that high-dose vitamin A supplements (HD-VAS) had no apparent effect on vitamin A (VA) status of Zambian children <5 y of age. To explore possible reasons for the lack of response to HD-VAS among Zambian children, we quantified the absorption, retention, and urinary elimination of either a single HDVAS (60 mg) or a smaller dose of stable isotope (SI)-labeled VA (5 mg), which was used to estimate VA pool size, in 3-4 y old Zambian boys (n = 4 for each VA dose). A 25 nCi tracer dose of [{sup 14}C{sub 2}]-labeled VA was co-administered with the HD-VAS or SI-labeled VA, and 24-hr stool and urine samples were collected for 3 and 7 consecutive days, respectively, and 24-hr urine samples at 4 later time points. Accelerator Mass Spectrometry (AMS) was used to measure the cumulative excretion of {sup 14}C in stool and urine 3d after dosing to estimate, respectively, absorption and retention of the VAS and SI-labeled VA. The urinary elimination rate (UER) was estimated by plotting {sup 14}C in urine vs. time, and fitting an exponential equation to the data. Estimates of mean absorption, retention and the UER were 83.8 {+-} 7.1%, 76.3 {+-} 6.7%, and 1.9 {+-} 0.6%/d, respectively, for the HD-VAS and 76.5 {+-} 9.5%, 71.1 {+-} 9.4%, and 1.8 {+-} 1.2%/d, respectively for the smaller dose of SI-labeled VA. Estimates of absorption, retention and the UER did not differ by size of the VA dose administered (P=0.26, 0.40, 0.88, respectively). Estimated absorption and retention were negatively associated with reported fever (P=0.011) and malaria (P =0.010). HD-VAS and SI-labeled VA were adequately absorbed, retained and utilized in apparently healthy Zambian preschool-age boys, although absorption and retention may be affected by recent infections.

  5. Pulsatile Drug Delivery System Based on Electrohydrodynamic Method

    E-Print Network [OSTI]

    Zheng, Yi; Hu, Junqiang; Gao, Wenle

    2012-01-01T23:59:59.000Z

    Electrohydrodynamic (EHD) generation, a commonly used method in BioMEMS, plays a significant role in the pulsatile drug delivery system for a decade. In this paper, an EHD based drug delivery system is well designed, which can be used to generate a single drug droplet as small as 2.83 nL in 8.5 ms with a total device of 2\\times2\\times3 mm^3, and an external supplied voltage of 1500 V. Theoretically, we derive the expressions for the size and the formation time of a droplet generated by EHD method, while taking into account the drug supply rate, properties of liquid, gap between two electrodes, nozzle size, and charged droplet neutralization. This work proves a repeatable, stable and controllable droplet generation and delivery system based on EHD method experimentally as well as theoretically.

  6. Retention of Hydrogen Isotopes in Neutron Irradiated Tungsten

    SciTech Connect (OSTI)

    Yuji Hatano; Masashi Shimada; Yasuhisa Oya; Guoping Cao; Makoto Kobayashi; Masanori Hara; Brad J. Merrill; Kenji Okuno; Mikhail A. Sokolov; Yutai Katoh

    2013-03-01T23:59:59.000Z

    To investigate the effects of neutron irradiation on hydrogen isotope retention in tungsten, disk-type specimens of pure tungsten were irradiated in the High Flux Isotope Reactor in Oak Ridge National Laboratory followed by exposure to high flux deuterium (D) plasma in Idaho National Laboratory. The results obtained for low dose n-irradiated specimens (0.025 dpa for tungsten) are reviewed in this paper. Irradiation at coolant temperature of the reactor (around 50 degrees C) resulted in the formation of strong trapping sites for D atoms. The concentrations of D in n-irradiated specimens were ranging from 0.1 to 0.4 mol% after exposure to D plasma at 200 and 500 degrees C and significantly higher than those in non-irradiated specimens because of D-trapping by radiation defects. Deep penetration of D up to a depth of 50-100 µm was observed at 500 degrees C. Release of D in subsequent thermal desorption measurements continued up to 900 degrees C. These results were compared with the behaviour of D in ion-irradiated tungsten, and distinctive features of n-irradiation were discussed.

  7. Formation and retention of methane in coal. Final report

    SciTech Connect (OSTI)

    Hucka, V.J.; Bodily, D.M.; Huang, H.

    1992-05-15T23:59:59.000Z

    The formation and retention of methane in coalbeds was studied for ten Utah coal samples, one Colorado coal sample and eight coal samples from the Argonne Premium Coal Sample Bank.Methane gas content of the Utah and Colorado coals varied from zero to 9 cm{sup 3}/g. The Utah coals were all high volatile bituminous coals. The Colorado coal was a gassy medium volatile bituminous coal. The Argonne coals cover a range or rank from lignite to low volatile bituminous coal and were used to determine the effect of rank in laboratory studies. The methane content of six selected Utah coal seams and the Colorado coal seam was measured in situ using a special sample collection device and a bubble desorbometer. Coal samples were collected at each measurement site for laboratory analysis. The cleat and joint system was evaluated for the coal and surrounding rocks and geological conditions were noted. Permeability measurements were performed on selected samples and all samples were analyzed for proximate and ultimate analysis, petrographic analysis, {sup 13}C NMR dipolar-dephasing spectroscopy, and density analysis. The observed methane adsorption behavior was correlated with the chemical structure and physical properties of the coals.

  8. Transparent hydrogel with enhanced water retention capacity by introducing highly hydratable salt

    E-Print Network [OSTI]

    Suo, Zhigang

    Transparent hydrogel with enhanced water retention capacity by introducing highly hydratable salt 2014; published online 14 October 2014) Polyacrylamide hydrogels containing salt as electrolyte have of polyacrylamide hydrogel by introducing highly hydratable salts into the hydrogel. These hydrogels show enhanced

  9. Abnormal Acidification of Melanoma Cells Induces Tyrosinase Retention in the Early Secretory Pathway*

    E-Print Network [OSTI]

    Hebert, Daniel N.

    Abnormal Acidification of Melanoma Cells Induces Tyrosinase Retention in the Early Secretory, Pennsylvania 19107 In tyrosinase-positive amelanotic melanoma cells, in- active tyrosinase accumulates-ATPase)-mediated proton transport in melanoma cells disrupts tyrosinase trafficking through the secretory pathway

  10. CHEMICAL TRACER RETENTION IN POROUS MEDIA Submitted to the Department of Petroleum Engineering

    E-Print Network [OSTI]

    Stanford University

    * CHEMICAL TRACER RETENTION IN POROUS MEDIA A Report Submitted to the Department of Petroleum Engineering of Stanford University in Fulfillment of the Requirement for the Degree of Master of Science

  11. Comparison of Different Forms of Creatine on Creatine Availability, Retention, and Training Adaptations 

    E-Print Network [OSTI]

    Jagim, Andrew Ryan

    2013-03-25T23:59:59.000Z

    The purpose of this study was to determine if a buffered creatine monohydrate (KA) that has been purported to promote greater creatine retention and training adaptations with fewer side effects at lower doses is more ...

  12. An Analysis of Texas Superintendents' Bilingual/ESL Teacher Recruitment and Retention Practices

    E-Print Network [OSTI]

    Lara-Alecio, Rafael; Galloway, Martha; Irby, Beverly J.; Brown, Genevieve

    2010-10-22T23:59:59.000Z

    year prior to the AAEE report, the Urban Teacher Collaborative Bilingual/ESL Teacher Recruitment/Retention 4 had already determined that bilingual educators were in very high demand, as were ESL teachers (The Urban Teacher Collaborative, 2000... organizations/conferences. Bilingual/ESL Teacher Recruitment/Retention 13 Several other questions related to recruitment were included on the survey. Response to a question related to in-district/in-state recruitment indicated that 53.4% (N=285...

  13. Retention of passive integrated transponder tags in largemouth bass brood fish

    SciTech Connect (OSTI)

    Harvey, W.D.; Campbell, D.L. (Texas Parks and Wildlife Dept., Austin (USA))

    1989-07-01T23:59:59.000Z

    Passive integrated transponder (PIT) tags were injected into 22 largemouth bass (Micropterus salmoides) brood fish to determine the retention rate of the tags, the effect on spawning success, and the utility of the tags as a means of individual fish identification. Fish were evaluated 12, 17, and 24 months after implantation. All tags were retained and all tagged fish were recognized. Tag injection and retention had no discernible effect on spawning success.

  14. Review of fission product retention experiment results and application to the LWR design

    SciTech Connect (OSTI)

    Lischer, D.J.; Elia, F.A. Jr. (Stone and Webster Engineering Corp., Boston, MA (United States))

    1992-01-01T23:59:59.000Z

    This paper examines the available literature on pipe retention of aerosols to determine the feasiblity of taking credit for attenuation of radioactive release from the plant through pipes when calculating off-site dose rates for plant licensing and emergency planning considerations. The results show that deposition in pipes can be significant. Experimental work on aerosol plugging shows that this phenomenon may provide the dominant mechanism for fission product retention.

  15. The retention and distribution of Salmonella typhimurium in the channel catfish (Ictalurus punctatus) 

    E-Print Network [OSTI]

    Cook, Gary Lee

    1981-01-01T23:59:59.000Z

    THE RETENTION AND DISTRIBUTION OF SALMONELLA TYPHIMURIUM IN THE CHANNEL CATFISH (ICTALURUS PUNCTATUS) A Thesis by GARY LEE COON Submitted to the Graduate College of' Texas A8d~ University in partial fulfillment of the requirement... for the degree of MASTER OF SCIENCE December Ig81 Major Subject: Veterinary Microbiology THE RETENTION AND DISTRIBUTION OF SALMONELLA TYPHIMURIUM IN THE CHANNEL CATFISH (ICTALURUS PUNCTATUS) A Thesis by GARY LEE COON Approved as to style and content by...

  16. informedRx Preferred Drug List -Effective July 1, 2012 Preferred Drug List

    E-Print Network [OSTI]

    Scharer, John E.

    informedRx Preferred Drug List - Effective July 1, 2012 Preferred Drug List Brand name drugs are listed in CAPITAL letters and generic drugs are listed in lowercase italics. Generic drugs are preferred, if available. If generic drugs are available and not listed on the formulary, but the brand name drug is

  17. Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance

    E-Print Network [OSTI]

    Wu, Alan HB

    2011-01-01T23:59:59.000Z

    this article as: Wu: Drug metabolizing enzyme activitiesgenetic variances for drug of clinical pharmacogenomicPROTEOMICS Open Access Drug metabolizing enzyme activities

  18. 61.99.01.V1.01 RETENTION OF STATE RECORDS Supplements System Regulation 61.99.01, Retention and

    E-Print Network [OSTI]

    ) will maintain an active and continuing state records management program in compliance with the Texas A&M System to manage and retain state records according to the Texas A&M System Regulations, Records Retention Schedule, and disposition of public records are established by the State and Local Records Management Division of the Texas

  19. Drug-drug similarity networks for anti-cancer drug discovery Case studies on Breast Cancer, Colorectal Cancer and Leukemia

    E-Print Network [OSTI]

    Zhou, Yaoqi

    Drug-drug similarity networks for anti-cancer drug discovery ­ Case studies on Breast Cancer the decades, the medical industry has been challenged with the issue of producing drugs that would avoid sidetracking to other targets (off-targets) and keep away from harmful side effects (drug adverse reactions

  20. Correlation of gas-chromatographic retention indices and high-order bonding indices for polycyclic aromatic hydrocarbons

    SciTech Connect (OSTI)

    Bulycheva, Z.Y.; Dylevskaya, L.V.; Kutenev, V.F.; Rudenko, B.A.

    1985-08-10T23:59:59.000Z

    The authors apply multifactor correlation equations between the retention indices on OV-101, OV-17, and PFMS-6 polysiloxanes and the bonding indices from the zeroth to fourth orders. Certain fragment descriptors are also applied which give higher significance levels and standard deviations for the retention indices less by 18-25 units, than do correlation equations between the retention indices and the first-order bonding indices.

  1. MODELING SHALLOW GROUNDWATER TABLE CONTRIBUTION TO SOIL WATER RETENTION IN THE UNSATURATED ZONE OF A CALCAREOUS SOIL OF SOUTH

    E-Print Network [OSTI]

    Migliaccio, Kati White

    1 MODELING SHALLOW GROUNDWATER TABLE CONTRIBUTION TO SOIL WATER RETENTION IN THE UNSATURATED ZONE...................................................................................................................................13 CHAPTER 1 GENERAL INTRODUCTION.............................................................................................................................15 Shallow Groundwater Capillarity

  2. antirheumatic drugs dmards: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  3. antineoplastic drugs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  4. antineoplastic drugs chimio-radiotherapie: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  5. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release is controlled by polymer degradation

  6. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    1 Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable The biodegradable polymer such as poly(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release

  7. Computer-Aided Drug Target Search

    E-Print Network [OSTI]

    Chen, Yuzong

    Identification of the unknown targets of drugs, investigative drugs and herbal ingredients is an important task in drug discovery. It can potentially help in several aspects including: (1) determination of unknown therapeutic ...

  8. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01T23:59:59.000Z

    2006. “The Market for Illegal Goods: The Case of Drugs. ”Informing America’s Policy on Illegal Drugs: What We Don’tViewpoints. Should Illegal Drugs Be Decriminalized? ” In

  9. Energy-band engineering for improved charge retention in fully self-aligned double floating-gate single-electron memories

    E-Print Network [OSTI]

    Xiaohui Tang; Christophe Krzeminski; Aurélien Lecavelier des Etangs-Levallois; Zhenkun Chen; Emmanuel Dubois; Erich Kasper; Alim Karmous; Nicolas Reckinger; Denis Flandre; Laurent A. Francis; Jean-Pierre Colinge; Jean-Pierre Raskin

    2011-11-15T23:59:59.000Z

    We present a new fully self-aligned single-electron memory with a single pair of nano floating gates, made of different materials (Si and Ge). The energy barrier that prevents stored charge leakage is induced not only by quantum effects but also by the conduction-band offset that arises between Ge and Si. The dimension and position of each floating gate are well defined and controlled. The devices exhibit a long retention time and single-electron injection at room temperature.

  10. Influence of rainfall on the retention of sludge trace metals by the leaves of forage crops

    E-Print Network [OSTI]

    Jones, Stephen Grady

    1977-01-01T23:59:59.000Z

    INFLUENCE OF RAINFALL ON THE RETENTION OF SLUDGE TRACE METALS BY THE LEAVES OF FORAGE CROPS A Thesis STEPHEN GRADY JONES Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree... of MASTER OF SCIENCE December 1977 Major Subject: Soil Science INFLUENCE OF RAINFALL ON THE RETENTION OF SLUDGE TRACE MFTALS BY THE LEAVES OF FORAGE CROPS A Thesis by STEPHEN GRADY JONES Approved a to style and content by: 1 (Chairman of Committee...

  11. Retention by vegetation of radionuclides deposited in rainfall: A literature summary

    SciTech Connect (OSTI)

    Anspaugh, L.R.

    1987-06-01T23:59:59.000Z

    Data include the results of experiments with artificial tracers and information from direct measurements of naturally occurring and fallout-produced radionuclides washed out or rained out by storms. Individual measurements of retention varied from negative to over 100%. The conclusion is that a value of 0.4 to 0.5 would be appropriate for average retention, and a value of 1.0 would not be unreasonable if one wished to be conservative, particularly where high vegetation densities might be expected. 35 refs., 16 tabs.

  12. Charge Retention by Organometallic Dications on Self-Assembled...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on gold was examined using in situ time-resolved secondary ion mass spectrometry in a Fourier transform ion cyclotron resonance apparatus (FT-ICR SIMS). FT-ICR SIMS analysis was...

  13. Exhibit 1C Patent Rights Retention by the Seller ITER UT-B Contracts Div Page 1 of 5

    E-Print Network [OSTI]

    Pennycook, Steve

    Exhibit 1C ­ Patent Rights ­ Retention by the Seller ­ ITER UT-B Contracts Div March 2007 Page 1 of 5 ex1c-ITER-mar07.doc Exhibit 1C ­ ITER Ref: DEAR 952.227-11 PATENT RIGHTS - RETENTION BY THE SELLER is or may be patentable or otherwise protectable under title 35 of the United States Code, or any novel

  14. Communications Drug Delivery

    E-Print Network [OSTI]

    Tan, Weihong

    ] Further, the strategy based on targeting a specific binding site is impeded by the heterogeneity of tumors exhibit pH values between 6.15 and 7.40 (the latter value representing the mean pH value of arterial blood of these polymeric nanoparticle systems is time-consuming and requires a technical knowledge of synthesis. Recently

  15. Intake retention functions and derived investigation levels for selected radioelements 

    E-Print Network [OSTI]

    Buitron Sanchez, Susana

    1990-01-01T23:59:59.000Z

    for radionuclide exposure control. Here, both routes of entry into the body are considered, i. e. , inhalation and ingestion, and ALI values are tabulated for both. 2. Introduction of the term Derived Air Concentration (DAC) instead of the term (MPC)a to prevent... per unit intake of the various quantities that can be measured: i. e. , activity in the body or an organ, or activity excreted per unit time, at time t, after a uni( intake. The derived investigation level for routine monitoring is then: DILR...

  16. DRUG STUDY QUESTIONNAIRE PROGRAM DIRECTOR:______________________________________ DATE:_____________________________

    E-Print Network [OSTI]

    Acton, Scott

    DRUG STUDY QUESTIONNAIRE PROGRAM DIRECTOR:______________________________________ DATE and/or efficacy of a drug? A. If yes, is the testing, study, evaluation or research primarily for use in pharmaceutical pre-market clearance applications to the Food and Drug Administration? 2. Is drug administered

  17. Finance Program Retention for FALL 2014 Instructions for Transcript Review Form

    E-Print Network [OSTI]

    Kostic, Milivoje M.

    Finance Program ­ Retention for FALL 2014 Instructions for Transcript Review Form College of Business at Northern Illinois University The Department of Finance Transcript Review Form should in the finance core). All NIU students are eligible to declare a major in Finance; however, students must meet

  18. REVIEW ARTICLE Pakistan Vet. J., 24(1): 2004 FACTORS CONTRIBUTING TO YOLK RETENTION

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    REVIEW ARTICLE Pakistan Vet. J., 24(1): 2004 46 FACTORS CONTRIBUTING TO YOLK RETENTION IN POULTRY Department of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan ABSTRACT Yolk) stated that it was the commonest cause of early chick mortality in Pakistan. Jordan (1990) and Singh et

  19. NMR investigations of water retention mechanism by cellulose ethers in cement-based materials

    E-Print Network [OSTI]

    Boyer, Edmond

    1 NMR investigations of water retention mechanism by cellulose ethers in cement-based materials J of freshly-mixed white cement pastes. NMRD is useful to determine the surface diffusion coefficient of water, the specific surface area and the hydration kinetics of the cement-based material. In spite of modifications

  20. Digestibility and energy retention by young rabbits fed different levels of intake

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Note Digestibility and energy retention by young rabbits fed different levels of intake Fernando in digestibility cages, were fed a standard diet at four levels of intake: ad libitum (AL), 60, 40 and 10 % of the AL intake. Digestibility of dietary dry matter, organic matter, crude protein, ether extract and ash

  1. Trace Metal Retention in the Incorporation Zone of Land-Applied

    E-Print Network [OSTI]

    Walter, M.Todd

    , with agricultural, forest, and range lands as well as land reclamation sites increasingly used for land applicationTrace Metal Retention in the Incorporation Zone of Land-Applied Sludge T A M M O S . S T E E N H U, Ithaca, New York 14853 Recycling nutrients in wastewater sludge (biosolids) via land application

  2. Mesh Width Influences Prey Retention in Spider Orb Webs Todd A. Blackledge & Jacquelyn M. Zevenbergen

    E-Print Network [OSTI]

    Blackledge, Todd

    Mesh Width Influences Prey Retention in Spider Orb Webs Todd A. Blackledge & Jacquelyn M. Zevenbergen Department of Biology, The University of Akron, Akron, OH, USA Introduction Orb webs depend upon threads, the sticky spirals of orb webs perform two important functions during prey cap- ture. First

  3. Toxicity of nickel to the earthworm and the applicability of the neutral red retention assay

    E-Print Network [OSTI]

    Hopkin, Steve

    Toxicity of nickel to the earthworm and the applicability of the neutral red retention assay JANECK of nickel on survival, growth, and reproduction of Eisenia veneta were investigated following 4 weeks of exposure to a nickel-chloride spiked loamy sand soil. The ability of a simple earthworm biomarker

  4. Background: Subsurface Water Retention Technology (SWRT) Durable and easy to install: Water

    E-Print Network [OSTI]

    Background: Subsurface Water Retention Technology (SWRT) Benefits Durable and easy to install: Water retaining membranes can last at least 40 years and can be installed quickly and costeffectively permeable marginal soils converting them to much higher production levels of food crops. Better water

  5. Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism

    E-Print Network [OSTI]

    Hebert, Daniel N.

    Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism, March 16, 2000 (received for review February 17, 2000) Tyrosinase is a melanocyte-specific enzyme albino substitution TYR(T373K), and the temperature-sensitive tyrosinase TYR(R402Q) Tyr(H402A) found

  6. Recent Advances on Hydrogenic Retention in ITER's Plasma-Facing Materials: BE, C, W.

    SciTech Connect (OSTI)

    Skinner, C H; Alimov, Kh; Bekris, N; Causey, R A; Clark, R.E.H.; Coad, J P; Davis, J W; Doerner, R P; Mayer, M; Pisarev, A; Roth, J

    2008-03-29T23:59:59.000Z

    Management of tritium inventory remains one of the grand challenges in the development of fusion energy and the choice of plasma-facing materials is a key factor for in-vessel tritium retention. The Atomic and Molecular Data Unit of the International Atomic Energy Agency organized a Coordinated Research Project (CRP) on the overall topic of tritium inventory in fusion reactors during the period 2001-2006. This dealt with hydrogenic retention in ITER's plasma-facing materials, Be, C, W, and in compounds (mixed materials) of these elements as well as tritium removal techniques. The results of the CRP are summarized in this article together with recommendations for ITER. Basic parameters of diffusivity, solubility and trapping in Be, C and W are reviewed. For Be, the development of open porosity can account for transient hydrogenic pumping but long term retention will be dominated by codeposition. Codeposition is also the dominant retention mechanism for carbon and remains a serious concern for both Be and C containing layers. Hydrogenic trapping in unirradiated tungsten is low but will increase with ion and neutron damage. Mixed materials will be formed in a tokamak and these can also retain significant amounts of hydrogen isotopes. Oxidative and photon-based techniques for detritiation of plasma-facing components are described.

  7. September 2013 Most Viewed Documents for Biology And Medicine...

    Office of Scientific and Technical Information (OSTI)

    September 2013 Most Viewed Documents for Biology And Medicine Science Subject Feed Drug Retention Times Center for Human Reliability Studies (2007) 29 > Oleoresin Capsicum...

  8. Strong-Sludge Gas Retention and Release Mechanisms in Clay Simulants

    SciTech Connect (OSTI)

    Gauglitz, Phillip A.; Buchmiller, William C.; Probert, Samuel G.; Owen, Antionette T.; Brockman, Fred J.

    2012-02-24T23:59:59.000Z

    The Hanford Site has 28 double-shell tanks (DSTs) and 149 single-shell tanks (SSTs) containing radioactive wastes that are complex mixes of radioactive and chemical products. The mission of the Department of Energy's River Protection Project is to retrieve and treat the Hanford tank waste for disposal and close the tank farms. A key aspect of the mission is to retrieve and transfer waste from the SSTs, which are at greater risk for leaking, into DSTs for interim storage until the waste is transferred to and treated in the Waste Treatment and Immobilization Plant. There is, however, limited space in the existing DSTs to accept waste transfers from the SSTs, and approaches to overcoming the limited DST space will benefit the overall mission. The purpose of this study is to summarize and analyze the key previous experiment that forms the basis for the relaxed controls and to summarize progress and results on new experiments focused on understanding the conditions that result in low gas retention. The previous large-scale test used about 50 m3 of sediment, which would be unwieldy for doing multiple parametric experiments. Accordingly, experiments began with smaller-scale tests to determine whether the desired mechanisms can be studied without the difficulty of conducting very large experiments. The most significant results from the current experiments are that progressively lower gas retention occurs in tests with progressively deeper sediment layers and that the method of gas generation also affects the maximum retention. Based on the results of this study, it is plausible that relatively low gas retention could occur in sufficiently deep tank waste in DSTs. The current studies and previous work, however, have not explored how gas retention and release will behave when two or more layers with different properties are present.

  9. HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS

    E-Print Network [OSTI]

    Kim, Duck O.

    containers, pickup hazardous drug waste and provide chemo spill kits to appropriate areas. The OfficeHAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC AND OTHER HAZARDOUS DRUGS, administration and disposal of drug residues. Drugs are classified as hazardous if studies in animals and

  10. Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic

    E-Print Network [OSTI]

    Getoor, Lise

    Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic Shobeir, USA getoor@cs.umd.edu ABSTRACT The high development cost and low success rate of drug dis- covery from appro- ved drugs. Computational methods can be effective in focu- sing efforts for such drug repurposing

  11. Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates to paclitaxel and the subsequent ring-opening polymerization of lactide. The drug-initiated, controlled(-caprolactone)) was also achieved through drug/(BDI-II)ZnN(TMS)2-mediated controlled polymerization. These drug

  12. ForPeerReview Drug user dynamics: a compartmental model of drug users

    E-Print Network [OSTI]

    Triolo, Livio

    ForPeerReview Only Drug user dynamics: a compartmental model of drug users for scenario analyses Journal: Drugs: Education, Prevention & Policy Manuscript ID: CDEP-2012-0094.R1 Manuscript Type: Original papers Keywords: Drug use, Epidemics, Compartmental modeling, Scenario analysis, Evaluation, Drug policy

  13. Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug-

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug- Poly(Ocarboxyanhydride) Nanoconjugates Qian Yin, Rong Tong,, Yunxiang Xu, Kwanghyun Baek of polymer-drug conjugates for nanoparticulate drug delivery: hydroxyl-containing drug (e.g., camptothecin

  14. Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery

    SciTech Connect (OSTI)

    Saha, Dipendu [ORNL] [ORNL; Warren, Kaitlyn E [ORNL] [ORNL; Naskar, Amit K [ORNL] [ORNL

    2014-01-01T23:59:59.000Z

    Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

  15. 8.6 Closeout The requirement for timely closeout is a grantee responsibility. Failure to submit timely and

    E-Print Network [OSTI]

    Acton, Scott

    8.6 Closeout The requirement for timely closeout is a grantee responsibility. Failure to submit for amounts due the grantee or NIH. Closeout of a grant does not automatically cancel any requirements for property accountability, record retention, or financial accountability. Following closeout, the grantee

  16. Rigor Through the Lens of Drug Discovery and Development

    E-Print Network [OSTI]

    flavors of incentives: economic, social, and moral. · Academic and Industrial cultures/ incentivesRigor Through the Lens of Drug Discovery and Development · The game · Culture and incentives · Our and development? · Resources: Money, time, and access to multiple non-academic skill sets · Incentives/ Culture

  17. Interim Report on Customer Acceptance, Retention, and Response to

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613 122Commercial602 1,39732on ArmedManufacturing |Time-Based Rates from the Consumer

  18. Now Available: Interim Report on Customer Acceptance, Retention, and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking ofOilNEWResponse to Time-Based Rates from the Consumer Behavior Studies |

  19. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

    E-Print Network [OSTI]

    Carlyle, Wenda C.

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

  20. A Discussion of SY-101 Crust Gas Retention and Release Mechanisms

    SciTech Connect (OSTI)

    SD Rassat; PA Gauglitz; SM Caley; LA Mahoney; DP Mendoza

    1999-02-23T23:59:59.000Z

    The flammable gas hazard in Hanford waste tanks was made an issue by the behavior of double-shell Tank (DST) 241-SY-101 (SY-101). Shortly after SY-101 was filled in 1980, the waste level began rising periodically, due to the generation and retention of gases within the slurry, and then suddenly dropping as the gases were released. An intensive study of the tank's behavior revealed that these episodic releases posed a safety hazard because the released gas was flammable, and, in some cases, the volume of gas released was sufficient to exceed the lower flammability limit (LFL) in the tank headspace (Allemann et al. 1993). A mixer pump was installed in SY-101 in late 1993 to prevent gases from building up in the settled solids layer, and the large episodic gas releases have since ceased (Allemann et al. 1994; Stewart et al. 1994; Brewster et al. 1995). However, the surface level of SY-101 has been increasing since at least 1995, and in recent months the level growth has shown significant and unexpected acceleration. Based on a number of observations and measurements, including data from the void fraction instrument (VFI), we have concluded that the level growth is caused largely by increased gas retention in the floating crust. In September 1998, the crust contained between about 21 and 43% void based on VFI measurements (Stewart et al. 1998). Accordingly, it is important to understand the dominant mechanisms of gas retention, why the gas retention is increasing, and whether the accelerating level increase will continue, diminish or even reverse. It is expected that the retained gas in the crust is flammable, with hydrogen as a major constituent. This gas inventory would pose a flammable gas hazard if it were to release suddenly. In May 1997, the mechanisms of bubble retention and release from crust material were the subject of a workshop. The evaluation of the crust and potential hazards assumed a more typical void of roughly 15% gas. It could be similar to percolati on in single-shell tank (SST) waste forms. The much higher void being currently observed in SY-101 represents essentially a new crust configuration, and the mechanisms for sudden gas release need to be evaluated. The purpose of this study is to evaluate the situation of gas bubbles in crust based on the previous work on gas bubble retention, migration, and release in simulants and actual waste. We have also conducted some visual observations of bubble migration through simulated crusts to help understand the interaction of the various mechanisms.

  1. Retention of Anionic Species on Granite: Influence of Granite Composition - 12129

    SciTech Connect (OSTI)

    Videnska, Katerina [Institute of Chemical Technology, Prague (Czech Republic); Havlova, Vaclava [Nuclear Research Institute Rez, Rez, 25068 (Czech Republic)

    2012-07-01T23:59:59.000Z

    Technetium (Tc-99, T{sub 1/2} = 2.1.10{sup 5} yrs) and selenium (Se-79, T{sub 1/2} = 6.5.10{sup 4} yrs) belong among fission products, being produced by fission of nuclear fuel. Both elements can significantly contribute to risk due to their complicated chemistry, long life times, high mobility and prevailing anionic character. Therefore, knowledge of migration behaviour under different conditions can significantly improve input into performance and safety assessment models. Granite is considered as a potential host rock for deep geological disposal of radioactive waste in many countries. Granitic rocks consist usually of quartz, feldspar, plagioclase (main components), mica, chlorite, kaolinite (minor components). The main feature of the rock is advection governed transport in fractures, complemented with diffusion process from fracture towards undisturbed rock matrix. The presented work is focused on interaction of anionic species (TcO{sub 4}{sup -}, SeO{sub 4}{sup 2-}, SeO{sub 3}{sup 2-}) with granitic rock. Furthermore, the importance of mineral composition on sorption of anionic species was also studied. The batch sorption experiments were conducted on the crushed granite from Bohemian Massive. Five fractions with defined grain size were used for static batch method. Mineral composition of each granitic fraction was evaluated using X-ray diffraction. The results showed differences in composition of granitic fractions, even though originating from one homogenized material. Sorption experiments showed influence of granite composition on adsorption of both TcO4{sup -} and SeO3{sup 2-} on granitic rock. Generally, Se(IV) showed higher retention than Tc(VII). Se(VI) was not almost sorbed at all. Fe containing minerals are pronounced as a selective Se and Tc sorbent, being reduced on their surface. As micas in granite are usually enriched in Fe, increased sorption of anionic species onto mica enriched fractions can be explained by this reason. On the other hand, fractions enriched in feldspar did not show increased sorption affinity to Tc and Se. (authors)

  2. A new metallographic procedure for edge retention of enclosed surfaces

    SciTech Connect (OSTI)

    Katz, O.M.

    1994-08-01T23:59:59.000Z

    Utilization of a low melting point, metallic alloy that on solidification has provided a reproducible means of preserving edges and accurately measuring deposits on surfaces mounted for metarographic study. In normal laboratory practice the electrically conducting mounting material generates no hazardous waste, needs no special equipment to prepare and is available commercially at a relatively reasonable price. Previous standard edge preservation techniques were found to be 90% inefficient from a time utilization view compared with the new procedure. This new mounting procedure has greatly improved the quality and efficiency of microstructural studies of all materials, especially those on the inside diameters of heat exchanger components. These studies have included reaction products, shallow creep cracks and deposits on tubing, for which the procedure has proved indispensable.

  3. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug is the probability that the tested individual uses this illegal drug? What is the probability of a false positive

  4. Solute retention in column liquid chromatography. X. Determination of solute infinite-dilution activity coefficients in methanol, water, and their mixtures, by combined gas-liquid and liquid-liquid chromatography

    SciTech Connect (OSTI)

    Djerki, R.A.; Laub, R.J.

    1988-01-01T23:59:59.000Z

    The Raoult's-law activity coefficients of 3- to 7-carbon aliphatic aldehyde, ketone, ester, and alcohol solutes at infinite dilution in methanol, water, and mixtures of the two and in polydimethysiloxane, all at 293-308 K, have been determined for the first time by appropriate combination of GLC and LLC retention data. The latter data are reported in terms of mole factions, while the former are given in concentration units of molality. However, interpretation of the data is difficult because of the multiplicity of the retention mechanisms. Nevertheless, the combined GLC/LLC technique, which had been applied previously only to pure solvents, is said to offer a number of advantages over static techniques for the determination of solute infinite-dilution activity coefficients with volatile solvents, especially with mixtures of solvents.

  5. Systems level characterizations of single and combination drug mechanisms of action in vitro and in vivo

    E-Print Network [OSTI]

    Pritchard, Justin (Justin Robert)

    2012-01-01T23:59:59.000Z

    Small molecule characterization is a critical limiting step in cancer drug development. At the present time, high throughput screens of natural products and combinatorial synthesis libraries generate more pharmaceutical ...

  6. A bright idea? : the promise and peril of a memory drug

    E-Print Network [OSTI]

    Dowd, William (William Michael)

    2007-01-01T23:59:59.000Z

    In the MIT lab of neuropharmacologist Richard Wurtman, rodents that received a new Alzheimer's drug have shown a marked improvement in learning and memory. They are able to master elaborate mazes in half the time of their ...

  7. Effects of Globally Waste Disturbing Activities on Gas Generation, Retention, and Release in Hanford Waste Tanks

    SciTech Connect (OSTI)

    Stewart, Charles W.; Fountain, Matthew S.; Huckaby, James L.; Mahoney, Lenna A.; Meyer, Perry A.; Wells, Beric E.

    2005-08-02T23:59:59.000Z

    Various operations are authorized in Hanford single- and double-shell tanks that disturb all or a large fraction of the waste. These globally waste-disturbing activities have the potential to release a large fraction of the retained flammable gas and to affect future gas generation, retention, and release behavior. This report presents analyses of the expected flammable gas release mechanisms and the potential release rates and volumes resulting from these activities. The background of the flammable gas safety issue at Hanford is summarized, as is the current understanding of gas generation, retention, and release phenomena. Considerations for gas monitoring and assessment of the potential for changes in tank classification and steady-state flammability are given.

  8. Rayleigh-Taylor Instability within Sediment Layers Due to Gas Retention: Preliminary Theory and Experiments

    SciTech Connect (OSTI)

    Gauglitz, Phillip A.; Wells, Beric E.; Buchmiller, William C.; Rassat, Scot D.

    2013-03-21T23:59:59.000Z

    In Hanford underground waste storage tanks, a typical waste configuration is settled beds of waste particles beneath liquid layers. The settled beds are typically composed of layers, and these layers can have different physical and chemical properties. One postulated configuration within the settled bed is a less-dense layer beneath a more-dense layer. The different densities can be a result of different gas retention in the layers or different degrees of settling and compaction in the layers. This configuration can experience a Rayleigh-Taylor (RT) instability where the less dense lower layer rises into the upper layer. Previous studies of gas retention and release have not considered potential buoyant motion within a settle bed of solids. The purpose of this report is to provide a review of RT instabilities, discuss predictions of RT behavior for sediment layers, and summarize preliminary experimental observations of RT instabilities in simulant experiments.

  9. Retention sleeve for a thermal medium carrying tube in a gas turbine

    DOE Patents [OSTI]

    Lathrop, Norman Douglas (Ballston Lake, NY); Czachor, Robert Paul (Cincinnati, OH)

    2003-01-01T23:59:59.000Z

    Multiple tubes are connected to steam supply and spent cooling steam return manifolds for supplying cooling steam to buckets and returning spent cooling steam from the buckets to the manifolds, respectively. The tubes are prevented from axial movement in one direction by flanges engaging end faces of the spacer between the first and second-stage wheels. Retention sleeves are disposed about cantilevered ends of the tubes. One end of the retention sleeve engages an enlarged flange on the tube, while an opposite end is spaced axially from an end face of the adjoining wheel, forming a gap, enabling thermal expansion of the tubes and limiting axial displacement of the tube in the opposite direction.

  10. Recruitment and retention initiatives for African American and Hispanic teachers in selected school districts in Texas

    E-Print Network [OSTI]

    Perry, Anita Jane

    2005-08-29T23:59:59.000Z

    RECRUITMENT AND RETENTION INITIATIVES FOR AFRICAN AMERICAN AND HISPANIC TEACHERS IN SELECTED SCHOOL DISTRICTS IN TEXAS A Dissertation by ANITA JANE PERRY Submitted to the Office of Graduate Studies of Texas A&M University... IN SELECTED SCHOOL DISTRICTS IN TEXAS A Dissertation by ANITA JANE PERRY Submitted to Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved as to style and content by...

  11. Heterosis and Heterosis Retention for Reproductive and Maternal Traits in Nellore-Angus Crossbred Cows

    E-Print Network [OSTI]

    Obeidat, Mohammad Diya Talal Hamed

    2013-07-08T23:59:59.000Z

    HETEROSIS AND HETEROSIS RETENTION FOR REPRODUCTIVE AND MATERNAL TRAITS IN NELLORE-ANGUS CROSSBRED COWS A Dissertation by MOHAMMAD DIYA TALAL HAMED OBEIDAT Submitted to the Office of Graduate Studies of Texas A&M University in partial... Subject: Animal Breeding Copyright 2013 Mohammad Diya Talal Hamed Obeidat ii ABSTRACT Calving rate, weaning rate, birth weight, weaning weight, and ADG from 1997 to 2011 were investigated in Angus, Nellore, F1 Nellore-Angus, first generation 3...

  12. The pipeline and future of drug development in schizophrenia

    E-Print Network [OSTI]

    Gray, J A; Roth, B L

    2007-01-01T23:59:59.000Z

    The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

  13. adverse drug effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

  14. antiepileptic drug effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

  15. Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

  16. Packaging for a drug delivery microelectromechanical system

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2005-01-01T23:59:59.000Z

    Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

  17. Financing drug discovery for orphan diseases

    E-Print Network [OSTI]

    Fagnan, David Erik

    Recently proposed ‘megafund’ financing methods for funding translational medicine and drug development require billions of dollars in capital per megafund to de-risk the drug discovery process enough to issue long-term ...

  18. Investigation of the use of nanofluids to enhance the In-Vessel Retention capabilities of Advanced Light Water Reactors

    E-Print Network [OSTI]

    Hannink, Ryan Christopher

    2007-01-01T23:59:59.000Z

    Nanofluids at very low concentrations experimentally exhibit a substantial increase in Critical Heat Flux (CHF) compared to water. The use of a nanofluid in the In-Vessel Retention (IVR) severe accident management strategy, ...

  19. Investigation of downward facing critical heat flux with water-based nanofluids for In-Vessel Retention applications

    E-Print Network [OSTI]

    DeWitt, Gregory L

    2011-01-01T23:59:59.000Z

    In-Vessel Retention ("IVR") is a severe accident management strategy that is power limiting to the Westinghouse AP1000 due to critical heat flux ("CHF") at the outer surface of the reactor vessel. Increasing the CHF level ...

  20. RETENTION OF STELLAR-MASS BLACK HOLES IN GLOBULAR CLUSTERS

    SciTech Connect (OSTI)

    Morscher, Meagan; Umbreit, Stefan; Farr, Will M.; Rasio, Frederic A., E-mail: m.morscher@u.northwestern.edu, E-mail: s-umbreit@northwestern.edu, E-mail: w-farr@northwestern.edu, E-mail: rasio@northwestern.edu [Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA), and Department of Physics and Astronomy, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (United States)

    2013-01-20T23:59:59.000Z

    Globular clusters should be born with significant numbers of stellar-mass black holes (BHs). It has been thought for two decades that very few of these BHs could be retained through the cluster lifetime. With masses {approx}10 M{sub Sun }, BHs are {approx}20 times more massive than an average cluster star. They segregate into the cluster core, where they may eventually decouple from the remainder of the cluster. The small-N core then evaporates on a short timescale. This is the so-called Spitzer instability. Here we present the results of a full dynamical simulation of a globular cluster containing many stellar-mass BHs with a realistic mass spectrum. Our Monte Carlo simulation code includes detailed treatments of all relevant stellar evolution and dynamical processes. Our main finding is that old globular clusters could still contain many BHs at present. In our simulation, we find no evidence for the Spitzer instability. Instead, most of the BHs remain well mixed with the rest of the cluster, with only the innermost few tens of BHs segregating significantly. Over the 12 Gyr evolution, fewer than half of the BHs are dynamically ejected through strong binary interactions in the cluster core. The presence of BHs leads to long-term heating of the cluster, ultimately producing a core radius on the high end of the distribution for Milky Way globular clusters (and those of other galaxies). A crude extrapolation from our model suggests that the BH-BH merger rate from globular clusters could be comparable to the rate in the field.

  1. Drug delivery Preparation of Monodisperse Biodegradable Polymer

    E-Print Network [OSTI]

    Prentiss, Mara

    Drug delivery Preparation of Monodisperse Biodegradable Polymer Microparticles Using a Microfluidic Flow-Focusing Device for Controlled Drug Delivery Qiaobing Xu, Michinao Hashimoto, Tram T. Dang, Todd microparticles have broad utility as vehicles for drug delivery and form the basis of several therapies approved

  2. prescription drug program highlights retail pharmacy prescriptions

    E-Print Network [OSTI]

    Scharer, John E.

    prescription drug program highlights SHIP retail pharmacy prescriptions The informedRx retail interactions and duplicate therapies. Brand name and generic drugs are included in your pharmacy benefit, but you will save the most money by selecting generic drug options when available. On myinformedRx.com you

  3. Imaging in Drug Discovery and Development

    E-Print Network [OSTI]

    Zanibbi, Richard

    Imaging in Drug Discovery and Development Raymond Gibson Senior Investigator Merck, Sharp and Dohme aaarrrccchhhiiivvveeesss aaannnddd aaabbbssstttrrraaaccctttsss... #12;Abstract With the desire to develop novel drugs faster and more cost-effectively, drug companies are searching for clear strategies to manage the complex

  4. CMVO Drug Testing Program Request for Information

    E-Print Network [OSTI]

    Mazzotti, Frank

    CMVO Drug Testing Program Request for Information TO: RE: Name (First, M.I., Last) Social Security substances testing records. Please complete this form and return it to: University of Florida CMVO Drug or she has tested positive, or refused to test, on any pre-employment drug or alcohol test administered

  5. Investigational Drug/Device Accountability Policy Introduction

    E-Print Network [OSTI]

    Subramanian, Venkat

    2/11/08 Investigational Drug/Device Accountability Policy Introduction: Good clinical research investigational drug or device used in a research trial at Washington University. This is true whether the study-initiated trial using department funds. Our institutional responsibility requires that any investigational drug

  6. A. UNIVERSITY POLICIES ON ILLEGAL DRUGS AND

    E-Print Network [OSTI]

    Wang, Yuqing

    A. UNIVERSITY POLICIES ON ILLEGAL DRUGS AND ALCOHOL In conformance with the existing law or be under the influence of illegal drugs and/or alcohol as prohibited by state and federal law at University enforcement agencies responsible for enforcing laws related to the use of illegal drugs and alcohol. Students

  7. TRENDS (Transport and Retention of Nuclides in Dominant Sequences): A code for modeling iodine behavior in containment during severe accidents

    SciTech Connect (OSTI)

    Weber, C.F.; Beahm, E.C.; Kress, T.S.; Daish, S.R.; Shockley, W.E.

    1989-01-01T23:59:59.000Z

    The ultimate aim of a description of iodine behavior in severe LWR accidents is a time-dependent accounting of iodine species released into containment and to the environment. Factors involved in the behavior of iodine can be conveniently divided into four general categories: (1) initial release into containment, (2) interaction of iodine species in containment not directly involving water pools, (3) interaction of iodine species in, or with, water pools, and (4) interaction with special systems such as ice condensers or gas treatment systems. To fill the large gaps in knowledge and to provide a means for assaying the iodine source term, this program has proceeded along two paths: (1) Experimental studies of the chemical behavior of iodine under containment conditions. (2) Development of TRENDS (Transport and Retention of Nuclides in Dominant Sequences), a computer code for modeling the behavior of iodine in containment and its release from containment. The main body of this report consists of a description of TRENDS. These two parts to the program are complementary in that models within TRENDS use data that were produced in the experimental program; therefore, these models are supported by experimental evidence that was obtained under conditions expected in severe accidents. 7 refs., 1 fig., 2 tabs.

  8. Detect adverse drug reactions for drug Atorvastatin Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Atorvastatin Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Atorvastatin. Major side

  9. Drug Saf . Author manuscript Discourse on safe drug use: symbolic logics and ethical aspects

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Drug Saf . Author manuscript Page /1 5 Discourse on safe drug use: symbolic logics and ethical.fainzang@orange.fr > Abstract Drug safety is not a matter for healthcare professionals alone. As actors, patients are also concerned, at three different levels: 1) with regard to their behaviour and choices of drugs, with a view

  10. 1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds

    E-Print Network [OSTI]

    Marchiori, Elena

    1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds using a weighted@cs.ru.nl,elenam@cs.ru.nl Abstract In silico discovery of interactions between drug compounds and target proteins is of core importance for improving the efficiency of the laborious and costly experimental determination of drug

  11. Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs

    E-Print Network [OSTI]

    Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs become empowered to share personal experiences regarding prescription drugs via Web page discussion from patient-provided drug reviews on health-related web sites. We focus on the statin class

  12. Detect adverse drug reactions for drug Simvastatin Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Simvastatin Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Simvastatin. Major side

  13. Detect adverse drug reactions for drug Alendronate Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Alendronate Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Alendronate. Major side

  14. 2012 Biennial Review: Drug-Free Schools and Communities Act and Drug-Free

    E-Print Network [OSTI]

    Tullos, Desiree

    2012 Biennial Review: Drug-Free Schools and Communities Act and Drug-Free Schools & Campuses from drugs and alcohol. The University supports programs for the prevention of abuse of alcohol. Biennial Review Process Oregon State University has a long history of engaging in drug and alcohol

  15. Detect adverse drug reactions for drug Pioglitazone Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Pioglitazone Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Pioglitazone. Major side

  16. Policy on Drug-Free Workplace Policy on Drug-Free Workplace

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Drug-Free Workplace 10/26/2014 Policy on Drug-Free Workplace I. Purpose and Scope responsible decision- making regarding the use of alcohol and other drugs. Northeastern strives to maintain drug use can create. Additionally, the University is committed to enforcing policies and laws realting

  17. SUMMARY OF FY11 SULFATE RETENTION STUDIES FOR DEFENSE WASTE PROCESSING FACILITY GLASS

    SciTech Connect (OSTI)

    Fox, K.; Edwards, T.

    2012-05-08T23:59:59.000Z

    This report describes the results of studies related to the incorporation of sulfate in high level waste (HLW) borosilicate glass produced at the Savannah River Site (SRS) Defense Waste Processing Facility (DWPF). A group of simulated HLW glasses produced for earlier sulfate retention studies was selected for full chemical composition measurements to determine whether there is any clear link between composition and sulfate retention over the compositional region evaluated. In addition, the viscosity of several glasses was measured to support future efforts in modeling sulfate solubility as a function of predicted viscosity. The intent of these studies was to develop a better understanding of sulfate retention in borosilicate HLW glass to allow for higher loadings of sulfate containing waste. Based on the results of these and other studies, the ability to improve sulfate solubility in DWPF borosilicate glasses lies in reducing the connectivity of the glass network structure. This can be achieved, as an example, by increasing the concentration of alkali species in the glass. However, this must be balanced with other effects of reduced network connectivity, such as reduced viscosity, potentially lower chemical durability, and in the case of higher sodium and aluminum concentrations, the propensity for nepheline crystallization. Future DWPF processing is likely to target higher waste loadings and higher sludge sodium concentrations, meaning that alkali concentrations in the glass will already be relatively high. It is therefore unlikely that there will be the ability to target significantly higher total alkali concentrations in the glass solely to support increased sulfate solubility without the increased alkali concentration causing failure of other Product Composition Control System (PCCS) constraints, such as low viscosity and durability. No individual components were found to provide a significant improvement in sulfate retention (i.e., an increase of the magnitude necessary to have a dramatic impact on blending, washing, or waste loading strategies for DWPF) for the glasses studied here. In general, the concentrations of those species that significantly improve sulfate solubility in a borosilicate glass must be added in relatively large concentrations (e.g., 13 to 38 wt % or more of the frit) in order to have a substantial impact. For DWPF, these concentrations would constitute too large of a portion of the frit to be practical. Therefore, it is unlikely that specific additives may be introduced into the DWPF glass via the frit to significantly improve sulfate solubility. The results presented here continue to show that sulfate solubility or retention is a function of individual glass compositions, rather than a property of a broad glass composition region. It would therefore be inappropriate to set a single sulfate concentration limit for a range of DWPF glass compositions. Sulfate concentration limits should continue to be identified and implemented for each sludge batch. The current PCCS limit is 0.4 wt % SO{sub 4}{sup 2-} in glass, although frit development efforts have led to an increased limit of 0.6 wt % for recent sludge batches. Slightly higher limits (perhaps 0.7-0.8 wt %) may be possible for future sludge batches. An opportunity for allowing a higher sulfate concentration limit at DWPF may lay lie in improving the laboratory experiments used to set this limit. That is, there are several differences between the crucible-scale testing currently used to define a limit for DWPF operation and the actual conditions within the DWPF melter. In particular, no allowance is currently made for sulfur partitioning (volatility versus retention) during melter processing as the sulfate limit is set for a specific sludge batch. A better understanding of the partitioning of sulfur in a bubbled melter operating with a cold cap as well as the impacts of sulfur on the off-gas system may allow a higher sulfate concentration limit to be established for the melter feed. This approach would have to be taken carefully to ensure that a

  18. Joint production and economic retention quantity decisions in capacitated production systems serving multiple market segments

    E-Print Network [OSTI]

    Katariya, Abhilasha Prakash

    2009-05-15T23:59:59.000Z

    : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : 44 VITA : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : 46 viii LIST OF FIGURES FIGURE Page 1 Sensitivity of the economic retention quantity with respect to the lost sales penalty when r1 = 100, p = 50, h = 12:5, E[X1...] = E[X2] = E[X3] = 100, C1 = C2 = C2 = 100 : : : : : : : : : : : : : : 36 2 Sensitivity of the optimal-produce up-to level with respect to the lost sales penalty when r1 = 100, p = 50, r2 = 40, h = 12:5, E[X1] = E[X2] = E[X3] = 100, C1 = C2 = C2 = 100...

  19. 242-A Evaporator/Liquid Effluent Retention Facility data quality objectives

    SciTech Connect (OSTI)

    Von Bargen, B.H.

    1994-09-29T23:59:59.000Z

    The purpose of data quality objectives (DQO) is to determine the most cost effective methods of gathering the essential data necessary to make decisions to support successful operation of the facility. The essential data is defined by such information as sample amount, sample location, required analyses, and how sampling and analyses are performed. Successful operation is defined as meeting the campaign objectives while operating within established requirements. This DQO document addresses that portion of the system from 242-A Evaporator candidate feed tanks through discharge of process condensate to the Liquid Effluent Retention of Facility (LERF). Later revisions will incorporate and integrate the entire system, including the Effluent Treatment Facility (ETF).

  20. Hanford Facility dangerous waste permit application, liquid effluent retention facility and 200 area effluent treatment facility

    SciTech Connect (OSTI)

    Coenenberg, J.G.

    1997-08-15T23:59:59.000Z

    The Hanford Facility Dangerous Waste Permit Application is considered to 10 be a single application organized into a General Information Portion (document 11 number DOE/RL-91-28) and a Unit-Specific Portion. The scope of the 12 Unit-Specific Portion is limited to Part B permit application documentation 13 submitted for individual, `operating` treatment, storage, and/or disposal 14 units, such as the Liquid Effluent Retention Facility and 200 Area Effluent 15 Treatment Facility (this document, DOE/RL-97-03). 16 17 Both the General Information and Unit-Specific portions of the Hanford 18 Facility Dangerous Waste Permit Application address the content of the Part B 19 permit application guidance prepared by the Washington State Department of 20 Ecology (Ecology 1987 and 1996) and the U.S. Environmental Protection Agency 21 (40 Code of Federal Regulations 270), with additional information needs 22 defined by the Hazardous and Solid Waste Amendments and revisions of 23 Washington Administrative Code 173-303. For ease of reference, the Washington 24 State Department of Ecology alpha-numeric section identifiers from the permit 25 application guidance documentation (Ecology 1996) follow, in brackets, the 26 chapter headings and subheadings. A checklist indicating where information is 27 contained in the Liquid Effluent Retention Facility and 200 Area Effluent 28 Treatment Facility permit application documentation, in relation to the 29 Washington State Department of Ecology guidance, is located in the Contents 30 Section. 31 32 Documentation contained in the General Information Portion is broader in 33 nature and could be used by multiple treatment, storage, and/or disposal units 34 (e.g., the glossary provided in the General Information Portion). Wherever 35 appropriate, the Liquid Effluent Retention Facility and 200 Area Effluent 36 Treatment Facility permit application documentation makes cross-reference to 37 the General Information Portion, rather than duplicating text. 38 39 Information provided in this Liquid Effluent Retention Facility and 40 200 Area Effluent Treatment Facility permit application documentation is 41 current as of June 1, 1997.

  1. November 13 - 15, 2012 HSS Work Group Leadership Meeting Summary - Work Force Retention

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of Contamination in ManyDepartment of Energy NorthB O|Work Force Retention Work Group

  2. Interim Report on Consumer Acceptance, Retention, and response to Time-based rates from the Consumer Behavior Studies

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment of EnergyIndustry15Among States in theWAPA1Interim Final

  3. Neuroimaging for drug addiction and related behaviors

    SciTech Connect (OSTI)

    Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

    2011-10-01T23:59:59.000Z

    In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

  4. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01T23:59:59.000Z

    treatment); health care costs (drug-related illnesses, injuries); reduced performance in school; reduced performance at workplace; poor parenting, child abuse;

  5. Emerging pathogens: Dynamics, mutation and drug resistance

    SciTech Connect (OSTI)

    Perelson, A.S.; Goldstein, B.; Korber, B.T. [and others

    1997-10-01T23:59:59.000Z

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objectives of this project were to develop models of the spread of pathogens, such as HIV-1 and influenza, in humans, and then to use the models to address the possibility of designing appropriate drug therapies that may limit the ability of the pathogen to escape treatment by mutating into a drug resistant form. We have developed a model of drug-resistance to amantidine and rimantadine, the two major antiviral drugs used to treat influenza, and have used the model to suggest treatment strategies during an epidemic.

  6. Analysis of Assembly Bill 310: Prescription Drugs

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01T23:59:59.000Z

    survey found that fourth-tier drug copayments averaged $85 in 2009 (KFF, Differential cost sharing is one utilization management technique plans

  7. RETENTION AND CHEMICAL SPECIATION OF URANIUM IN A WETLAND ON THE SAVANNAH RIVER SITE

    SciTech Connect (OSTI)

    Li, D.; CHANG, H.: SEAMAN, J.; Jaffe, P.; Groos, P.; Jiang, D.; Chen, N.; Lin, J.; Arthur, Z.; Scheckel, K.; Kaplan, D.

    2013-06-17T23:59:59.000Z

    Uranium speciation and retention mechanism onto Savannah River Site (SRS) wetland sediments was studied using batch (ad)sorption experiments, sequential extraction desorption tests and U L{sub 3}-edge X-ray absorption near-edge structure (XANES) spectroscopy of contaminated wetland sediments. U was highly retained by the SRS wetland sediments. In contrast to other similar but much lower natural organic matter (NOM) sediments, significant sorption of U onto the SRS sediments was observed at pH <4 and pH >8. Sequential extraction tests indicated that the U(VI) species were primarily associated with the acid soluble fraction (weak acetic acid extractable) and NOM fraction (Na-pyrophosphate extractable). Uranium L3- edge XANES spectra of the U-retained sediments were nearly identical to that of uranyl acetate. The primary oxidation state of U in these sediments was as U(VI), and there was little evidence that the high sorptive capacity of the sediments could be ascribed to abiotic or biotic reduction to the less soluble U(IV) species. The molecular mechanism responsible for the high U retention in the SRS wetland sediments is likely related to the chemical bonding of U to organic carbon.

  8. Radionuclide Retention Mechanisms in Secondary Waste-Form Testing: Phase II

    SciTech Connect (OSTI)

    Um, Wooyong; Valenta, Michelle M.; Chung, Chul-Woo; Yang, Jungseok; Engelhard, Mark H.; Serne, R. Jeffrey; Parker, Kent E.; Wang, Guohui; Cantrell, Kirk J.; Westsik, Joseph H.

    2011-09-26T23:59:59.000Z

    This report describes the results from laboratory tests performed at Pacific Northwest National Laboratory (PNNL) for Washington River Protection Solutions (WRPS) to evaluate candidate stabilization technologies that have the potential to successfully treat liquid secondary waste stream effluents produced by the Hanford Tank Waste Treatment and Immobilization Plant (WTP). WRPS is considering the design and construction of a Solidification Treatment Unit (STU) for the Effluent Treatment Facility (ETF) at Hanford. The ETF, a multi-waste, treatment-and-storage unit that has been permitted under the Resource Conservation and Recovery Act (RCRA), can accept dangerous, low-level, and mixed wastewaters for treatment. The STU needs to be operational by 2018 to receive secondary liquid waste generated during operation of the WTP. The STU will provide the additional capacity needed for ETF to process the increased volume of secondary waste expected to be produced by WTP. This report on radionuclide retention mechanisms describes the testing and characterization results that improve understanding of radionuclide retention mechanisms, especially for pertechnetate, {sup 99}TcO{sub 4}{sup -} in four different waste forms: Cast Stone, DuraLith alkali aluminosilicate geopolymer, encapsulated fluidized bed steam reforming (FBSR) product, and Ceramicrete phosphate bonded ceramic. These data and results will be used to fill existing data gaps on the candidate technologies to support a decision-making process that will identify a subset of the candidate waste forms that are most promising and should undergo further performance testing.

  9. Computational Method for Drug Target Search and Application in Drug Discovery

    E-Print Network [OSTI]

    Chen, Yuzong

    Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug. A protein structure database is searched to find proteins to which a drug can bind ...

  10. Mechanisms of gas retention and release: Experimental results for Hanford waste tanks 241-AW-101 and 241-AN-103

    SciTech Connect (OSTI)

    Rassat, S.D.; Gauglitz, P.A.; Bredt, P.R.; Mahoney, L.A.; Forbes, S.V.; Tingey, S.M.

    1997-09-01T23:59:59.000Z

    The 177 storage tanks at Hanford contain a vast array of radioactive waste forms resulting, primarily, from nuclear materials processing. Through radiolytic, thermal, and other decomposition reactions of waste components, gaseous species including hydrogen, ammonia, and the oxidizer nitrous oxide are generated within the waste tanks. Many of these tanks are known to retain and periodically release quantities of these flammable gas mixtures. The primary focus of the Flammable Gas Project is the safe storage of Hanford tank wastes. To this end, we strive to develop an understanding of the mechanisms of flammable gas retention and release in Hanford tanks through laboratory investigations on actual tank wastes. These results support the closure of the Flammable Gas Unreviewed Safety Question (USQ) on the safe storage of waste tanks known to retain flammable gases and support resolution of the broader Flammable Gas Safety Issue. The overall purpose of this ongoing study is to develop a comprehensive and thorough understanding of the mechanisms of flammable gas retention and release. The first objective of the current study was to classify bubble retention and release mechanisms in two previously untested waste materials from Tanks 241-AN-103 (AN-103) and 241-AW-101 (AW-101). Results were obtained for retention mechanisms, release characteristics, and the maximum gas retention. In addition, unique behavior was also documented and compared with previously studied waste samples. The second objective was to lengthen the duration of the experiments to evaluate the role of slowing bubble growth on the retention and release behavior. Results were obtained for experiments lasting from a few hours to a few days.

  11. New safety concerns over diabetes drugs Two drugs commonly prescribed to treat diabetes

    E-Print Network [OSTI]

    Feigon, Brooke

    New safety concerns over diabetes drugs Two drugs commonly prescribed to treat diabetes double of Type II Diabetes. Prescriptions for the drugs, known as thiazolidinediones, have doubled over the last. The results are published in the August edition of the journal Diabetes Care. Congregation 2007 page 5­9 Race

  12. POLICY STATEMENT ON DRUG-FREE CAMPUS*

    E-Print Network [OSTI]

    Karsai, Istvan

    11 POLICY STATEMENT ON DRUG-FREE CAMPUS* It is the policy of ETSU that the unlawful manufacture, distribution, possession, use of alcohol and illicit drugs on the ETSU campus, in the workplace (on or off campus), on property owned or controlled by ETSU, or as part of any activity of ETSU is strictly

  13. Novel polyoxazolines polymer drug delivery platform

    E-Print Network [OSTI]

    performed with 4 different polymers in multi- drug resistant (MCF7/ADR) human adenocarcinoma cells, non-resistant (MCF7) human adenocarcinoma cells and Madin-Darby canine kidney (MDCK) cells. All polymers were found lines. 2. To investigate the effect of the addition of drugs to the polymers on cell toxicity, micelles

  14. Pricing in the Market for Anticancer Drugs

    E-Print Network [OSTI]

    Howard, David H.

    In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab— brand name Yervoy—at $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

  15. Prescription Drug List --To be used by members

    E-Print Network [OSTI]

    Mullins, Dyche

    Prescription Program Drug List -- To be used by members (both National Accounts and Local Group), who have a tiered drug plan. Anthem Blue Cross prescription drug benefits include medications available on the Anthem Drug List. Our prescription drug benefits can offer potential savings when your

  16. Plant and microbial controls on nitrogen retention and loss in a Humid Tropical Forest

    SciTech Connect (OSTI)

    Templer, P.; Silver, W.; Pett-Ridge, J.; DeAngelis, K.M.; Firestone, M.K.

    2009-09-15T23:59:59.000Z

    Humid tropical forests are generally characterized by the lack of nitrogen (N) limitation to net primary productivity, yet paradoxically have high potential for N loss. We conducted an intensive field experiment with {sup 15}NH{sub 4} and {sup 15}NO{sub 3} additions to highly weathered tropical forest soils to determine the relative importance of N retention and loss mechanisms. Over half of all the NH{sub 4}{sup +} produced from gross mineralization was rapidly converted to NO{sub 3}{sup -} during the process of gross nitrification. During the first 24 h plant roots took up 28 % of the N mineralized, dominantly as NH{sub 4}{sup +}, and were a greater sink for N than soil microbial biomass. Soil microbes were not a significant sink for added {sup 15}NH{sub 4}{sup +} or {sup 15}NO{sub 3}{sup -} during the first 24 hr, and only for {sup 15}NH{sub 4}{sup +} after 7 d. Patterns of microbial community composition, as determined by Terminal Restriction Fragment Length Polymorphism analysis, were weakly, but significantly correlated with nitrification and denitrification to N{sub 2}O. Rates of dissimilatory NO{sub 3}{sup -} reduction to NH{sub 4}{sup +} (DNRA) were high in this forest, accounting for up to 25 % of gross mineralization and 35 % of gross nitrification. DNRA was a major sink for NO{sub 3}{sup -} which may have contributed to the lower rates of N{sub 2}O and leaching losses. Despite considerable N conservation via DNRA and plant NH{sub 4}{sup +} uptake, the fate of approximately 45% of the NO{sub 3}{sup -} produced and 22% of the NH{sub 4}{sup +} produced were not measured in our fluxes, suggesting that other important pathways for N retention and loss (e.g., denitrification to N{sub 2}) are important in this system. The high proportion of mineralized N that was rapidly nitrified and the fates of that NO{sub 3}{sup -} highlight the key role of gross nitrification as a proximate control on N retention and loss in humid tropical forest soils. Furthermore, our results demonstrate the importance of the coupling between DNRA and plant uptake of NH{sub 4}{sup +} as a potential N conserving mechanism within tropical forests.

  17. The following values were studied : pH, water retention ability, coloring, transformation yield, amount of residual nitrite, and distributior of sodium chloride in the finished product.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    The following values were studied : pH, water retention ability, coloring, transformation yield, amount of residual nitrite, and distributior of sodium chloride in the finished product. As a general sampling sites, lard weight, coloration index, and water retention ability in fresh ham. Values obtained

  18. antiretroviral treatment start-time: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    parking, depending on time Sjlander, Kimmen 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  19. anti-tuberculosis drug ethionamide: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  20. anti-parkinsonian drug selegiline: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  1. Pakistan Vt. ./., 22(4): 2002 A STUDY ON THE PATHOGENESIS OF YOLK RETENTION IN BROILER CHICKS

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Pakistan Vêt. ./., 22(4): 2002 A STUDY ON THE PATHOGENESIS OF YOLK RETENTION IN BROILER CHICKS Laboratories Complex. Lahore, Pakistan ABSTRACT The présent project was designed to identify thé factors commonest cause of early chick mortality in Pakistan (Anjum, 1997). Whcn thé chick émerges from it's shell

  2. ALTERATION OF KAOLINITE TO CANCRINITE AND SODALITE BY SIMULATED HANFORD TANK WASTE AND ITS IMPACT ON CESIUM RETENTION

    E-Print Network [OSTI]

    Flury, Markus

    ON CESIUM RETENTION HONGTING ZHAO, YOUJUN DENG, JAMES B. HARSH, MARKUS FLURY* AND JEFFREY S. BOYLE--Cancrinite, Cation Exchange, Cesium Sorption, Feldspathoid , Hanford Waste Tanks, Kaolinite, Mineral Stability and transport of tank contaminants. Recent studies have shown that cancrinite, a feldspathoid, was formed after

  3. Revised By: Lucy Paltoo, Retention Specialist & Mentor Program Coordinator Revised: August 10, 2012 2012-2013 Mentee Application

    E-Print Network [OSTI]

    Revised By: Lucy Paltoo, Retention Specialist & Mentor Program Coordinator Revised: August 10, 2012 2012-2013 Mentee Application If you'd like to be paired with an AAC Mentor for the 2012-2013 academic year, please complete and submit this application. Applications for mentoring will be reviewed

  4. Revised By: Lucy Paltoo, AAC Retention Specialist & Mentor Program Coordinator Last Revised: March 2012 2012 -2013 Peer Mentor Position Description

    E-Print Network [OSTI]

    Rutledge, Steven

    Revised By: Lucy Paltoo, AAC Retention Specialist & Mentor Program Coordinator Last Revised: March 2012 2012 - 2013 Peer Mentor Position Description Thank you for your interest in applying to be a Peer Mentor for the AAC Mentoring for Leadership program. The Peer Mentor is a volunteer member

  5. Revised By: Lucy Paltoo, Retention Specialist & Mentor Program Coordinator Revised: March 2012 Peer Mentor Application 2012-2013

    E-Print Network [OSTI]

    Rutledge, Steven

    Revised By: Lucy Paltoo, Retention Specialist & Mentor Program Coordinator Revised: March 2012 Peer Mentor Application 2012-2013 To be consider for a Peer Mentor position for the 2012-2013 academic year information or if you have any questions, please contact Mentor Program Coordinator, Lucy Paltoo. Contact

  6. Revised By: Lucy Paltoo, Retention Specialist & Mentor Program Coordinator Revised: January 2013 Peer Mentor Application 2013-2014

    E-Print Network [OSTI]

    Stephens, Graeme L.

    Revised By: Lucy Paltoo, Retention Specialist & Mentor Program Coordinator Revised: January 2013 Peer Mentor Application 2013-2014 To be consider for a Peer Mentor position for the 2013-2014 academic year, please complete and submit this application along with a copy of your resume. Peer Mentor

  7. Forest carbon storage in the northeastern United States: Net effects of harvesting frequency, post-harvest retention, and wood products

    E-Print Network [OSTI]

    Vermont, University of

    26 December 2009 Keywords: Carbon sequestration Wood products Structural retention Harvesting tradeoffs among scenarios using a factorial treatment design and two-way ANOVA. Mean carbon sequestrationForest carbon storage in the northeastern United States: Net effects of harvesting frequency, post

  8. ISU Policy Library All of this information can be found Under the ISU Policy Library --File retention.

    E-Print Network [OSTI]

    Chen, Tsing-Chang "Mike"

    ISU Policy Library All of this information can be found Under the ISU Policy Library -- File retention. http://records.policy.iastate.edu/ Here are a few links we pulled out for you to get you started: · Personnel Files -- http://records.policy.iastate.edu/view.php?id=151 · Accounting Transactions

  9. The Mate Retention Inventory-Short Form (MRI-SF) David M. Buss a,*, Todd K. Shackelford b

    E-Print Network [OSTI]

    Pillow, Jonathan

    The Mate Retention Inventory-Short Form (MRI-SF) David M. Buss a,*, Todd K. Shackelford b , William . E-mail address: dbuss@psy.utexas.edu (D.M. Buss). www.elsevier.com/locate/paid Personality distinct domains--effort devoted to attracting a mate (Buss, 1988a; Buss & Schmitt, 1996) and effort

  10. RETENTION OF IRB RECORDS AND OTHER DOCUMENTS All IRB files and documents that relate to the protection of human research

    E-Print Network [OSTI]

    site. The IRB File Manager and eIRB support staff are available to scan paper documents as needed into Paperhost. The File Manager and all the Board Specialists have access to documents kept on the Paperhost web1 RETENTION OF IRB RECORDS AND OTHER DOCUMENTS 04/18/2011 All IRB files and documents that relate

  11. Chest Swelling and Fever in an Intravenous Drug User

    E-Print Network [OSTI]

    Grijalva, Ray A.; Ritter, Michael; Langdorf, Mark I.

    2008-01-01T23:59:59.000Z

    aeruginosa serotype 011 from drug addicts. J Infect Dis,JA, Pierre JD. Injection drug use in North America. Infectand Fever in an Intravenous Drug User Ray A. Grijalva Jr. ,

  12. RESEARCH Open Access Impact of physical incompatibility on drug mass

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    RESEARCH Open Access Impact of physical incompatibility on drug mass flow rates: example drugs simultaneously but through limited venous accesses. Several intravenous therapies have rates of drugs infused simultaneously to the patient, through an in vitro study. Methods: Furosemide

  13. Drug Discovery and Development from Marine Biology-Based Research

    E-Print Network [OSTI]

    Jawitz, James W.

    Drug Discovery and Development from Marine Biology- Based Research Oceanyx Pharmaceuticals is a novel drug discovery and development company that leverages marine biology-based natural identified two lead candidates, largazole and apratoxin, as potential drug candidates for the treatment

  14. Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug

    E-Print Network [OSTI]

    Hill, Wendell T.

    Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug manufacturing, drug delivery, and medical diagnostics. By learning how substances behave differently's Nanotechnology Center are creating novel tools and developing new methods for crucial research areas of drug

  15. Prescription Drug Monitoring Programs: Examining Limitations and Future Approaches

    E-Print Network [OSTI]

    Griggs, Christopher A.; Weiner, Scott G.; Feldman, James A.

    2015-01-01T23:59:59.000Z

    Li G, Brady JE, Lang B, et al. Prescription drug monitoringand drug overdose mortality. Inj Epidemiol. 2014;1:1-9.EM, Desai HA. Prescription drug monitoring programs and

  16. FORMATION OF A PHYSICALLY STABLE AMORPHOUS DRUG COMPLEX

    E-Print Network [OSTI]

    MacLean, Jenifer Anne

    2010-12-16T23:59:59.000Z

    ABSTRACT In this paper we explore the use of Neusilin, an inorganic magnesium aluminometasilicate, to stabilize the amorphous form of an acidic drug a neutral drug and two basic drugs. Both cryomilling and ball milling of ...

  17. WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    14 WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria Vincent Breton, Doman Kim ................................................................................ 354 14.2 Grid-Enabled Drug Discovery .................................................. 354 14.2.1 In Silico Drug Discovery: Requirements and Grid Added Value

  18. A resorbable polymeric microreservoir device for controlled release drug delivery

    E-Print Network [OSTI]

    Grayson, Amy Catherine Richards, 1975-

    2003-01-01T23:59:59.000Z

    The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

  19. Proper Usage of Drugs and Chemicals in Food Animals

    E-Print Network [OSTI]

    Faries Jr., Floron C.

    2002-02-15T23:59:59.000Z

    Federal regulations exist to ensure the proper distribution and usage of veterinary drugs and to prevent adulteration of the food supply with illegal drug residues through drug misuse in food produc- ing animals. The Food and Drug Administration... of omission or commission, violative residues in livestock and poultry (by irresponsible and illegal distribution and use of drugs) violates state and federal laws. When FSIS inspectors detect violative drug residues in food products derived from ani- mals...

  20. Enhancement of the predicted drug hepatotoxicity in gel entrapped hepatocytes within polysulfone-g-poly (ethylene glycol) modified hollow fiber

    SciTech Connect (OSTI)

    Shen Chong [Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou, Zhejiang 310027 (China); Zhang Guoliang [Institute of Biological and Environmental Engineering, Zhejiang University of Technology, Zhejiang 310012 (China); Meng Qin, E-mail: mengq@zju.edu.c [Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou, Zhejiang 310027 (China)

    2010-12-01T23:59:59.000Z

    Collagen gel-based 3D cultures of hepatocytes have been proposed for evaluation of drug hepatotoxicity because of their more reliability than traditional monolayer culture. The collagen gel entrapment of hepatocytes in hollow fibers has been proven to well reflect the drug hepatotoxicity in vivo but was limited by adsorption of hydrophobic drugs onto hollow fibers. This study aimed to investigate the impact of hollow fibers on hepatocyte performance and drug hepatotoxicity. Polysulfone-g-poly (ethylene glycol) (PSf-g-PEG) hollow fiber was fabricated and applied for the first time to suppress the drug adsorption. Then, the impact of hollow fibers was evaluated by detecting the hepatotoxicity of eight selected drugs to gel entrapped hepatocytes within PSf and PSf-g-PEG hollow fibers, or without hollow fibers. The hepatocytes in PSf-g-PEG hollow fiber showed the highest sensitivity to drug hepatotoxicity, while those in PSf hollow fiber and cylindrical gel without hollow fiber underestimated the hepatotoxicity due to either drug adsorption or low hepatic functions. Therefore, the 3D culture of gel entrapped hepatocytes within PSf-g-PEG hollow fiber would be a promising tool for investigation of drug hepatotoxicity in vitro.

  1. Structural genomics of infectious disease drug targets: the SSGCID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

  2. E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

  3. Emergence of HIV-1 Drug Resistance During Antiretroviral Treatment

    E-Print Network [OSTI]

    2007-04-20T23:59:59.000Z

    Smith and Wahl (2005) used an impulsive differential equation to model drug ... In Smith (2006), the dynamics of drug are modeled by impulsive differential ...

  4. DOE Laboratories Help Develop Promising New Cancer Fighting Drug...

    Office of Environmental Management (EM)

    Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm...

  5. Apoferritin-based nanomedicine platform for drug delivery: equilibrium...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA. Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study...

  6. antiepileptic drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of drug design and development Bommarius Reading Jan 15 Tutorial Sherrill, David 28 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  7. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01T23:59:59.000Z

    how drug policy reformers used the ballot initiative processand future directions for reformers. Bock’s (2000) work isto analyze how drug policy reformers frame their actions and

  8. Intradermal needle-free powdered drug injection

    E-Print Network [OSTI]

    Liu, John (John Hsiao-Yung)

    2012-01-01T23:59:59.000Z

    This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

  9. Computational model of local intravascular drug delivery

    E-Print Network [OSTI]

    Balakrishnan, Brinda

    2007-01-01T23:59:59.000Z

    Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

  10. Transdermal drug delivery by localized intervention

    E-Print Network [OSTI]

    Weaver, James C.

    Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

  11. NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM

    E-Print Network [OSTI]

    Hart, Steven N.

    2011-02-22T23:59:59.000Z

    Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

  12. Entropic Time

    SciTech Connect (OSTI)

    Caticha, Ariel [Department of Physics, University at Albany-SUNY, Albany, NY 12222 (United States)

    2011-03-14T23:59:59.000Z

    The formulation of quantum mechanics within the framework of entropic dynamics includes several new elements. In this paper we concentrate on one of them: the implications for the theory of time. Entropic time is introduced as a book-keeping device to keep track of the accumulation of changes. One new feature is that, unlike other concepts of time appearing in the so-called fundamental laws of physics, entropic time incorporates a natural distinction between past and future.

  13. biocompatibility, stability, , p-p multi-drug

    E-Print Network [OSTI]

    Hong, Deog Ki

    , biocompatibility, stability, , p-p .2 Ø multi-drug resistance gene co- delivered photothermal , , . Ø , biocompatibility, stability, , p-p .2 Ø multi-drug resistance gene co graphene oxide-para amino benzoic acid nanosheet as effective drug delivery system to treat drug resistant

  14. Drug Delivery DOI: 10.1002/anie.200802260

    E-Print Network [OSTI]

    Zare, Richard N.

    Drug Delivery DOI: 10.1002/anie.200802260 Sustained Release of Drugs Dispersed in Polymer) was observed for up to 40 days with up to 90% drug recovery. In vivo bioluminescence imaging of transgenic mice, represents a new drug delivery approach with great potential, particularly if particles can be targeted

  15. SIXTEENTH INTERNATIONAL SYMPOSIUM ON RECENT ADVANCES IN DRUG

    E-Print Network [OSTI]

    Tipple, Brett

    SIXTEENTH INTERNATIONAL SYMPOSIUM ON RECENT ADVANCES IN DRUG DELIVERY SYSTEMS Register on-line: www on Recent Advances in Drug Delivery Systems "Drug Delivery: the penetrating challenges" Pioneering event in the field New drug targeting methods Improved delivery strategies Imaging and treatment combinations

  16. B. Comp Dissertation SNP Data Integration and Analysis for Drug-

    E-Print Network [OSTI]

    Wong, Limsoon

    B. Comp Dissertation SNP Data Integration and Analysis for Drug- Response Biomarker Discovery 2008/2009 #12;i B. Comp Dissertation SNP Data Integration and Analysis for Drug- Response methods to develop drugs targeted at various diseases. To maximize drug viability and profit, one

  17. Illegal Drugs Policy Swansea University and Students' Union

    E-Print Network [OSTI]

    Martin, Ralph R.

    Illegal Drugs Policy Swansea University and Students' Union #12;Illegal Drugs Policy for Swansea 2. Who is covered by the policy? 3. Aims of the policy 5. What do we mean by illegal drugs? 4 illegal drug use. · Take very seriously our legal duty of care to our students, staff and visitors and aim

  18. In-vessel coolability and retention of a core melt. Volume 2

    SciTech Connect (OSTI)

    Theofanous, T.G.; Liu, C.; Additon, S.; Angelini, S.; Kymaelaeinen, O.; Salmassi, T. [California Univ., Santa Barbara, CA (United States). Center for Risk Studies and Safety

    1996-10-01T23:59:59.000Z

    The efficacy of external flooding of a reactor vessel as a severe accident management strategy is assessed for an AP600-like reactor design. The overall approach is based on the Risk Oriented Accident Analysis Methodology (ROAAM), and the assessment includes consideration of bounding scenarios and sensitivity studies, as well as arbitrary parametric evaluations that allow the delineation of the failure boundaries. Quantification of the input parameters is carried out for an AP600-like design, and the results of the assessment demonstrate that lower head failure is physically unreasonable. Use of this conclusion for any specific application is subject to verifying the required reliability of the depressurization and cavity-flooding systems, and to showing the appropriateness (in relation to the database presented here, or by further testing as necessary) of the thermal insulation design and of the external surface properties of the lower head, including any applicable coatings. The AP600 is particularly favorable to in-vessel retention. Some ideas to enhance the assessment basis as well as performance in this respect, for applications to larger and/or higher power density reactors are also provided.

  19. Preliminary Study of Strong-Sludge Gas Retention and Release Mechanisms in Clay Simulants

    SciTech Connect (OSTI)

    Gauglitz, Phillip A.; Buchmiller, William C.; Probert, Samuel G.; Owen, Antionette T.

    2010-10-12T23:59:59.000Z

    The Hanford Site has 28 double-shell tanks (DSTs) and 149 single-shell tanks (SSTs) containing radioactive wastes that are complex mixes of radioactive and chemical products. The mission of the Department of Energy’s River Protection Project is to retrieve and treat the Hanford tank waste for disposal and close the tank farms. A key aspect of the mission is to retrieve and transfer waste from the SSTs, which are at greater risk for leaking, into DSTs for interim storage until the waste is transferred to and treated in the Waste Treatment and Immobilization Plant. There is, however, limited space in the existing DSTs to accept waste transfers from the SSTs, and approaches to overcoming the limited DST space will benefit the overall mission. The purpose of this study is to summarize and analyze the key previous experiment that forms the basis for the relaxed controls and to summarize initial progress and results on new experiments focused on understanding the conditions that result in low gas retention. The work is ongoing; this report provides a summary of the initial findings. The previous large-scale test used about 50 m3 of sediment, which would be unwieldy for doing multiple parametric experiments. Accordingly, experiments will begin with smaller-scale tests to determine whether the desired mechanisms can be studied without the difficulty of conducting very large experiments.

  20. Influence of salts on the sulfur retention of limestone in atmospheric fluidized-bed combustors

    SciTech Connect (OSTI)

    Smith, G.W.; Lenc, J.F.; Shearer, J.A.; Chopra, O.K.; Myles, K.M.; Johnson, I.

    1981-06-01T23:59:59.000Z

    Increased utilization of the available CaO can reduce the amount of limestone required for SO/sub 2/ retention in atmospheric fluidized-bed combustion systems. In laboratory experiments, a pretreatment with inorganic salts, such as NaCl, CaCl/sub 2/, or Na/sub 2/CO/sub 3/, has been found to be an effective method of improving the CaO utilization. This report provides quantitative information on the effectiveness of the same sulfation-enhancement salts in reducing the limestone requirements in an atmospheric fluidized-bed combustor (AFBC). Some laboratory experiments indicated that only 0.1 mol % of salt was required to produce the structural changes in the limestone necessary to increase the CaO utilization. In contrast, the AFBC runs indicated that as much as 2.0 mol % salt was required to obtain a significant increase in the CaO utilization. The increased utilization of the salt-treated limestone in the AFBC reduced the total amount of limestone needed to meet the EPA emission standard for sulfur dioxide to one-half of that required when no treatment is used.

  1. In-vessel coolability and retention of a core melt. Volume 1

    SciTech Connect (OSTI)

    Theofanous, T.G.; Liu, C.; Additon, S.; Angelini, S.; Kymaelaeinen, O.; Salmassi, T. [California Univ., Santa Barbara, CA (United States). Center for Risk Studies and Safety

    1996-10-01T23:59:59.000Z

    The efficacy of external flooding of a reactor vessel as a severe accident management strategy is assessed for an AP600-like reactor design. The overall approach is based on the Risk Oriented Accident Analysis Methodology (ROAAM), and the assessment includes consideration of bounding scenarios and sensitivity studies, as well as arbitrary parametric evaluations that allow the delineation of the failure boundaries. Quantification of the input parameters is carried out for an AP600-like design, and the results of the assessment demonstrate that lower head failure is physically unreasonable. Use of this conclusion for any specific application is subject to verifying the required reliability of the depressurization and cavity-flooding systems, and to showing the appropriateness (in relation to the database presented here, or by further testing as necessary) of the thermal insulation design and of the external surface properties of the lower head, including any applicable coatings. The AP600 is particularly favorable to in-vessel retention. Some ideas to enhance the assessment basis as well as performance in this respect, for applications to larger and/or higher power density reactors are also provided.

  2. Evaluation of in-vessel corium retention through external reactor vessel cooling for integral reactor

    SciTech Connect (OSTI)

    Park, R. J.; Lee, J. R.; Kim, S. B.; Jin, Y.; Kim, H. Y. [Korea Atomic Energy Research Inst., 1045 Daedeok-daero, Yuseong-gu, Daejeon, 305-353 (Korea, Republic of)

    2012-07-01T23:59:59.000Z

    In-vessel corium retention through external reactor vessel cooling (IVR-ERVC) for a small integral reactor has been evaluated to determine the thermal margin for the prevention of a reactor vessel failure. A thermal load analysis from the corium pool to the outer reactor vessel wall in the lower plenum of the reactor vessel has been performed to determine the heat flux distribution. The critical heat flux (CHF) on the outer reactor vessel wall has been determined to fix the maximum heat removal rate through the external coolant between the outer reactor vessel and the insulation of the reactor vessel. Finally, the thermal margin has been evaluated by comparison of the thermal load with the maximum heat removal rate of the CHF on the outer reactor vessel wall. The maximum heat flux from the corium pool to the outer reactor vessel is estimated at approximately 0.25 MW/m{sup 2} in the metallic layer because of the focusing effect. The CHF of the outer reactor vessel is approximately 1.1 MW/m{sup 2} because of a two phase natural circulation mass flow. Since the thermal margin for the IVR-ERVC is sufficient, the reactor vessel integrity is maintained during a severe accident of a small integral reactor. (authors)

  3. Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing

    E-Print Network [OSTI]

    Gates, Kent. S.

    CHEM 4170 Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing assignment, this is a literature research project. The data for your drug will be presented below. Do not choose a drug that has been discussed in detail in Silverman's Book or in class. You may

  4. Automatic Drug-Drug Interaction Detection: A Machine Learning Approach With Maximal

    E-Print Network [OSTI]

    Rosso, Paolo

    Automatic Drug-Drug Interaction Detection: A Machine Learning Approach With Maximal Frequent-level and character-level have been proven to have a high discrim- inative power for detecting DDI, while pattern% precision and 84% recall. In [3] the authors propose a first approximation for DDI detection based

  5. In-Vessel Retention Technology Development and Use for Advanced PWR Designs in the USA and Korea

    SciTech Connect (OSTI)

    T.G. Theofanous; S.J. Oh; J.H. Scobel

    2004-05-18T23:59:59.000Z

    In-Vessel Retention (IVR) of molten core debris by means of external reactor vessel flooding is a cornerstone of severe accident management for Westinghouse's AP600 (advanced passive light water reactor) design. The case for its effectiveness (made in previous work by the PI) has been thoroughly documented, reviewed as part of the licensing certification, and accepted by the US Nuclear Regulatory Commission. A successful IVR would terminate a severe accident, passively, with the core in a stable, coolable configuration (within the lower head), thus avoiding the largely uncertain accident evolution with the molten debris on the containment floor. This passive plant design has been upgraded by Westinghouse to the AP1000, a 1000 MWe plant very similar to the AP600. The severe accident management approach is very similar too, including In-Vessel Retention as the cornerstone feature, and initial evaluations indicated that this would be feasible at the higher power as well. A similar strategy is adopted in Korea for the APR1400 plant. The overall goal of this project is to provide experimental data and develop the necessary basic understanding so as to allow the robust extension of the AP600 In-Vessel Retention strategy for severe accident management to higher power reactors, and in particular, to the AP1000 advanced passive design.

  6. Summary of remedial investigations at the 307 retention basins and 307 trenches (316-3), 300-FF-2 Operable Unit

    SciTech Connect (OSTI)

    Hulstrom, L.C.

    1994-06-30T23:59:59.000Z

    Remedial investigations at the 307 retention basins and 307 trenches (316-3) in the 300 Area of the Hanford Site were conducted as part of the 300-FF-1 operable unit Phase 1 remedial investigation (RI) in accordance with the approved RI work plan. During the RI, the southwestern boundary of the 300-FF-1 operable unit was modified by all signatories to the Hanford Federal Facility Agreement and Consent Order, which shifted the 307 retention basins and 307 trenches to the 300-FF-3 operable unit. As a consequence, the RI results from these waste management units were not included in the Phase 1 Remedial Investigation Report for the 300-FF-1 Operable Unit. As a results of recent Hanford Federal Facility Agreement and Consent Order negotiations, the 300-FF-2 operable unit now consists of the remaining 300 Area operable units within the 300 Area National Priorities List (NPL), which includes the former 300-FF-3 operable unit. Therefore, this document summarizes the RI results from the 307 retention basins and 307 trenches in the 300-FF-2 operable unit. Analysis and evaluation of these results well be included in the 300-FF-2 RI report.

  7. An identification of policies and practices that hinder and facilitate the admission and retention of Hispanics in institutions of higher education 

    E-Print Network [OSTI]

    Cantu, Linda Valdez

    2006-04-12T23:59:59.000Z

    and that facilitate or hinder institutions of higher education in the recruitment, admission, retention, and graduation of students, particularly Hispanic students. The researcher utilized the Delphi method to conduct the study. This research method produces a...

  8. Factor influencing the recruitment and retention of undergradutes as reported by African-American graduates of Texas A&M University between May 1998 and December 2003 

    E-Print Network [OSTI]

    Harnsberry, John Gabriel

    2005-11-01T23:59:59.000Z

    The purpose of this study was to examine the influential effects various factors had on the recruitment and the retention of African American undergraduates at Texas A&M University, as perceived by those African Americans ...

  9. Successful practices in teacher recruitment, preparation and retention as perceived by the Texas A&M University System Regents' Initiative project directors

    E-Print Network [OSTI]

    Holt, Michael Lee

    2006-10-30T23:59:59.000Z

    The purpose of the study is to identify the perceived successful practices that led to improved teacher recruitment, preparation and retention efforts within the nine universities of The Texas A&M University System brought about by the Regents...

  10. The impact of an alternative certification program on teacher retention in selected Texas public school districts as reported by personnel in Education Service Center, Region 20, Texas

    E-Print Network [OSTI]

    Goldhorn, Jeffery Lee

    2005-11-01T23:59:59.000Z

    The purpose of this study was to determine the impact of an alternative certification program on the retention of teachers in Region 20, Texas, as reported by Education Service Center, Region 20, Texas. Demographic variables were used to determine...

  11. 5.16: LIBRARY RETENTION, TENURE AND PROMOTIONS CRITERIA Approved by Library Faculty, Department Co-Chairs, and University Librarian 9/21/06

    E-Print Network [OSTI]

    5.16: LIBRARY RETENTION, TENURE AND PROMOTIONS CRITERIA Approved by Library Faculty, Department Co in Library Assignment and amplifications are noted below for Professional Achievement and Growth & Research Libraries (ACRL), the national organization associated with academic librarians. For tenure

  12. Successful practices in teacher recruitment, preparation and retention as perceived by the Texas A&M University System Regents' Initiative project directors 

    E-Print Network [OSTI]

    Holt, Michael Lee

    2006-10-30T23:59:59.000Z

    The purpose of the study is to identify the perceived successful practices that led to improved teacher recruitment, preparation and retention efforts within the nine universities of The Texas A&M University System brought ...

  13. EXPERIMENTAL STUDY OF CRITICAL HEAT FLUX WITH ALUMINA-WATER NANOFLUIDS IN DOWNWARD-FACING CHANNELS FOR IN-VESSEL RETENTION APPLICATIONS

    E-Print Network [OSTI]

    Park, R.J.

    The Critical Heat Flux (CHF) of water with dispersed alumina nanoparticles was measured for the geometry and flow conditions relevant to the In-Vessel Retention (IVR) situation which can occur during core melting sequences ...

  14. Drugdiscoverytypicallyinvestigatesinteractionsbetween a lead compound (for example, a potential drug) and a

    E-Print Network [OSTI]

    mass transfer (Fick's law), heat dissipation, multi- plexing (arrays) or the surface-to-volume ratio of drug discovery and development5,6 . More fundamentally, scaling laws predict that molec- ular assays. A tenfold reduction in size should lead to a 100-fold increase in the time to result in molecular binding

  15. DRUG DELIVERY IN BIOLOGICAL TISSUES: AN APPLICATION TO THE ELUTING STENT

    E-Print Network [OSTI]

    Pontrelli, Giuseppe

    [3]. The present work provides a fundamental study of the mass transfer process of a substance across range and it is recognized that the time and quantity of release of the drug is crucial for the therapy models predicting the dynamics of solute concentration and mass flux are of interest for biomedical

  16. Exhibit 1C Patent Rights-Retention by the Seller (Short Form) UT-B Contracts Div Page 1 of 3

    E-Print Network [OSTI]

    Pennycook, Steve

    Exhibit 1C ­ Patent Rights-Retention by the Seller (Short Form) UT-B Contracts Div Mar 2001 Page 1 of 3 ex1C-mar01format2005 Exhibit 1C Ref: DEAR 952.227-11 PATENT RIGHTS - RETENTION BY THE SELLER be patentable or otherwise protectable under title 35 of the United States Code, or any novel variety of plant

  17. Above- and below-ground Litter Manipulation: Effect on Retention and Release of DOC, DON and DIN in the Sikfokut Forest, Hungary

    E-Print Network [OSTI]

    Evetts, Elizabeth A.; Peterson, Jacqueline A.

    2009-09-30T23:59:59.000Z

    ABOVE- AND BELOW-GROUND LITTER MANIPULATION: EFFECT ON RETENTION AND RELEASE OF DOC, DON AND DIN IN THE SIKFOKUT FOREST, HUNGARY A Senior Scholars Thesis by ELIZABETH A. EVETTS Submitted to the Office...: EFFECT ON RETENTION AND RELEASE OF DOC, DON AND DIN IN THE SIKFOKUT FOREST, HUNGARY A Senior Scholars Thesis by ELIZABETH A. EVETTS Submitted to the Office of Undergraduate Research Texas A&M University in partial...

  18. Protein-Based Nanomedicine Platforms for Drug Delivery

    SciTech Connect (OSTI)

    Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

    2009-08-03T23:59:59.000Z

    Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drug’s efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein based drug delivery system.

  19. Federal Student Aid Penalties for Drug Convictions Students convicted of a federal or state offense or possessing illegal drugs that occurred while they were

    E-Print Network [OSTI]

    Sadeh, Norman M.

    offense or possessing illegal drugs that occurred while they were receiving federal student aid should convictions for conspiring to sell drugs.) Possession of Sale of illegal Illegal drugs drugs 1st offense 1

  20. Pretreatment Nomogram to Predict the Risk of Acute Urinary Retention After I-125 Prostate Brachytherapy

    SciTech Connect (OSTI)

    Roeloffzen, Ellen M., E-mail: e.m.a.roeloffzen@umcutrecht.nl [Department of Radiation Oncology, University Medical Center Utrecht (Netherlands); Vulpen, Marco van; Battermann, Jan J. [Department of Radiation Oncology, University Medical Center Utrecht (Netherlands); Roermund, Joep G. van [Department of Urology, University Medical Center Utrecht (Netherlands); Saibishkumar, Elantholi P. [Department of Radiation Oncology, Princess Margaret Hospital, Toronto, ON (Canada); Monninkhof, Evelyn M. [Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht (Netherlands)

    2011-11-01T23:59:59.000Z

    Purpose: Acute urinary retention (AUR) after iodine-125 (I-125) prostate brachytherapy negatively influences long-term quality of life and therefore should be prevented. We aimed to develop a nomogram to preoperatively predict the risk of AUR. Methods: Using the preoperative data of 714 consecutive patients who underwent I-125 prostate brachytherapy between 2005 and 2008 at our department, we modeled the probability of AUR. Multivariate logistic regression analysis was used to assess the predictive ability of a set of pretreatment predictors and the additional value of a new risk factor (the extent of prostate protrusion into the bladder). The performance of the final model was assessed with calibration and discrimination measures. Results: Of the 714 patients, 57 patients (8.0%) developed AUR after implantation. Multivariate analysis showed that the combination of prostate volume, IPSS score, neoadjuvant hormonal treatment and the extent of prostate protrusion contribute to the prediction of AUR. The discriminative value (receiver operator characteristic area, ROC) of the basic model (including prostate volume, International Prostate Symptom Score, and neoadjuvant hormonal treatment) to predict the development of AUR was 0.70. The addition of prostate protrusion significantly increased the discriminative power of the model (ROC 0.82). Calibration of this final model was good. The nomogram showed that among patients with a low sum score (<18 points), the risk of AUR was only 0%-5%. However, in patients with a high sum score (>35 points), the risk of AUR was more than 20%. Conclusion: This nomogram is a useful tool for physicians to predict the risk of AUR after I-125 prostate brachytherapy. The nomogram can aid in individualized treatment decision-making and patient counseling.

  1. Comparison of Deuterium Retention for Ion-irradiated and Neutron-irradiated Tungsten

    SciTech Connect (OSTI)

    Yasuhisa Oya; Masashi Shimada; Makoto Kobayashi; Takuji Oda; Masanori Hara; Hideo Watanabe; Yuji Hatano; Pattrick Calderoni; Kenji Okuno

    2011-12-01T23:59:59.000Z

    The behavior of D retention for Fe{sup 2+}-irradiated tungsten with a damage of 0.025-3 dpa was compared with that for neutron-irradiated tungsten with 0.025 dpa. The D{sub 2} thermal desorption spectroscopy (TDS) spectra for Fe{sup 2+}-irradiated tungsten consisted of two desorption stages at 450 and 550 K, while that for neutron-irradiated tungsten was composed of three stages and an addition desorption stage was found at 750 K. The desorption rate of the major desorption stage at 550K increased as the displacement damage increased due to Fe{sup 2+} irradiation increasing. In addition, the first desorption stage at 450K was found only for damaged samples. Therefore, the second stage would be based on intrinsic defects or vacancy produced by Fe{sup 2+} irradiation, and the first stage should be the accumulation of D in mono-vacancy and the activation energy would be relatively reduced, where the dislocation loop and vacancy is produced. The third one was found only for neutron irradiation, showing the D trapping by a void or vacancy cluster, and the diffusion effect is also contributed to by the high full-width at half-maximum of the TDS spectrum. Therefore, it can be said that the D{sub 2} TDS spectra for Fe{sup 2+}-irradiated tungsten cannot represent that for the neutron-irradiated one, indicating that the deuterium trapping and desorption mechanism for neutron-irradiated tungsten is different from that for the ion-irradiated one.

  2. This Is Your Data on Drugs: Lessons Computer Security Can Learn From The Drug War

    E-Print Network [OSTI]

    Sadeh, Norman M.

    policy surrounding computer security. 1. INTRODUCTION The last three years have seen a growing amount in using observed market prices to draw conclu- sions about illicit drugs, such as marijuana, cocaine

  3. Drug and alcohol abuse: The pattern and magnitude of the problem

    SciTech Connect (OSTI)

    Ajayi, P.A.

    1996-12-31T23:59:59.000Z

    In the last 12 months, many more cases of alcohol and drug (substance) abuse in the workplace were seen in the Escravos operations of Chevron Nigeria Limited than in previous years. This called the attention to the rising prevalence of drug and alcohol abuse in contradistinction to reports from similar organizations in other parts of the world. Chevron Nigeria has a written Drug and Alcohol Policy which has been dormant for some time because of the apparent rarity of the problem of substance abuse in the workplace. This Policy is being reviewed to broaden its scope and make it more effective. A total of 30 employees were tested for drugs and alcohol .6 exceeded the legal limits of Blood Alcohol Concentration (BAC) and 5 tested positive for drugs. Tests were mainly post-accident, reasonable cause and random. The common substances abused were alcohol, cannabis, cocaine and morphine in that order. The findings are compared with those of similar organizations in UK and USA. Efforts to control substance abuse in the workplace are being put into place.

  4. Just in time | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    simulation programs. This research is important for toxic waste disposal, nuclear waste storage, carbon sequestration, energy storage, drug discovery, disease treatment,...

  5. Attitudes toward the integration of smoking cessation treatment into drug abuse clinics.

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    Direct Care Workforce in the National Drug Abuse Treatmentdependence treatment into drug abuse care reduces thesecare settings but not yet in independent drug abuse treatment

  6. A Juarez drug lord saved my life. Confessions of an accidental narco

    E-Print Network [OSTI]

    Cruz Rosas, Monica

    2013-01-01T23:59:59.000Z

    Cruz Rosas A Juarez drug lord saved my life Confessions ofarrest someone involved in drug trafficking, they make sureviolent years of the Mexican drug war. Five armed soldiers

  7. Research paper Drug diffusion and binding in ionizable interpenetrating networks

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    Research paper Drug diffusion and binding in ionizable interpenetrating networks from poly) (PVA), poly(acrylic acid) (PAA), and their interpenetrating networks (IPNs) were prepared using by measuring their equilibrium polymer volume fraction, equilibrium swelling ratio, and mesh size. Drug

  8. Optimization of preclinical profiling operations in drug discovery

    E-Print Network [OSTI]

    Heiney, John P. (John Patrick)

    2007-01-01T23:59:59.000Z

    In early-stage drug discovery, thousands of compounds must be tested using in vitro assays to determine their exposure and safety characteristics. This data is used to guide the selection of potential drug candidates and ...

  9. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  10. Use of Preventative and Therapeutic Drugs in Show Market Animals

    E-Print Network [OSTI]

    Faries Jr., Floron C.

    2001-03-12T23:59:59.000Z

    Various medicines are used in show market livestock and poultry, but exhibitors must ensure that the carcasses do not contain illegal residues of drugs, chemicals and feed additives. Only approved substances should be used. Illegal uses of drugs...

  11. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Takeda Advances Diabetes Drug Development at the ALS Print Tuesday, 19 May 2015 12:25 Type 2 diabetes mellitus (T2DM),...

  12. Luminal flow amplifies stent-based drug deposition in arterial

    E-Print Network [OSTI]

    Levine, Evan G.

    Background: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely ...

  13. Specific and general binding in arterial drug delivery

    E-Print Network [OSTI]

    Levin, Andrew D. (Andrew David), 1976-

    2005-01-01T23:59:59.000Z

    Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

  14. Alignment strategies for drug product process development and manufacturing

    E-Print Network [OSTI]

    Garvin, Christopher John

    2012-01-01T23:59:59.000Z

    The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the product-process interaction ...

  15. Results of Large-Scale Testing on Effects of Anti-Foam Agent on Gas Retention and Release

    SciTech Connect (OSTI)

    Stewart, Charles W.; Guzman-Leong, Consuelo E.; Arm, Stuart T.; Butcher, Mark G.; Golovich, Elizabeth C.; Jagoda, Lynette K.; Park, Walter R.; Slaugh, Ryan W.; Su, Yin-Fong; Wend, Christopher F.; Mahoney, Lenna A.; Alzheimer, James M.; Bailey, Jeffrey A.; Cooley, Scott K.; Hurley, David E.; Johnson, Christian D.; Reid, Larry D.; Smith, Harry D.; Wells, Beric E.; Yokuda, Satoru T.

    2008-01-03T23:59:59.000Z

    The U.S. Department of Energy (DOE) Office of River Protection’s Waste Treatment Plant (WTP) will process and treat radioactive waste that is stored in tanks at the Hanford Site. The waste treatment process in the pretreatment facility will mix both Newtonian and non-Newtonian slurries in large process tanks. Process vessels mixing non-Newtonian slurries will use pulse jet mixers (PJMs), air sparging, and recirculation pumps. An anti-foam agent (AFA) will be added to the process streams to prevent surface foaming, but may also increase gas holdup and retention within the slurry. The work described in this report addresses gas retention and release in simulants with AFA through testing and analytical studies. Gas holdup and release tests were conducted in a 1/4-scale replica of the lag storage vessel operated in the Pacific Northwest National Laboratory (PNNL) Applied Process Engineering Laboratory using a kaolin/bentonite clay and AZ-101 HLW chemical simulant with non-Newtonian rheological properties representative of actual waste slurries. Additional tests were performed in a small-scale mixing vessel in the PNNL Physical Sciences Building using liquids and slurries representing major components of typical WTP waste streams. Analytical studies were directed at discovering how the effect of AFA might depend on gas composition and predicting the effect of AFA on gas retention and release in the full-scale plant, including the effects of mass transfer to the sparge air. The work at PNNL was part of a larger program that included tests conducted at Savannah River National Laboratory (SRNL) that is being reported separately. SRNL conducted gas holdup tests in a small-scale mixing vessel using the AZ-101 high-level waste (HLW) chemical simulant to investigate the effects of different AFAs, their components, and of adding noble metals. Full-scale, single-sparger mass transfer tests were also conducted at SRNL in water and AZ-101 HLW simulant to provide data for PNNL’s WTP gas retention and release modeling.

  16. Model-Based Dependability Analysis of Programmable Drug Infusion Pumps

    E-Print Network [OSTI]

    Sankaranarayanan, Sriram

    Model-Based Dependability Analysis of Programmable Drug Infusion Pumps Sriram Sankaranarayanan.lastname@colorado.edu Abstract. Infusion pumps are commonly used in home/hospital care to inject drugs into a patient a case-study involving an infusion pump used to manage pain through the infusion of analgesic drugs

  17. Drug-Free Federal Workplace Testing Implementation Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1988-07-29T23:59:59.000Z

    The order provides guidance and policy for the administration, application and implementation of the DOE Drug-free Federal Workplace Plan and other regulations that facilitate the maintenance of a drug-free Federal workplace through the establishment of programs to test for the use of illegal drugs. Chg 1, dated 8-21-92

  18. Similarity Between Obesity and Drug Addiction as Assessed

    E-Print Network [OSTI]

    Homes, Christopher C.

    Similarity Between Obesity and Drug Addiction as Assessed by Neurofunctional Imaging: A Concept. Overeating in obese individuals shares similarities with the loss of control and compulsive drug taking]: "Similarity Between Obesity and Drug Addiction as Assessed by Neurofunctional Imaging: A Concept Review." Wang

  19. Meeting the FDA's Initiative for Protecting the US Drug Supply

    E-Print Network [OSTI]

    Brock, David

    Meeting the FDA's Initiative for Protecting the US Drug Supply Tatsuya Inaba Research Affiliate rapidly. Demographic changes, along with a host of new drugs, are causing greater volumes of raw materials. To achieve these goals for the public good, the Food and Drug Administration (FDA) and individual States

  20. 1. Introduction 2. Apicoplast as a drug target

    E-Print Network [OSTI]

    McFadden, Geoff

    1. Introduction 2. Apicoplast as a drug target 3. Conclusion 4. Expert opinion Review Targeting an excellent drug target. Areas covered: This review focuses on the biological role of the apicoplast in the erythrocytic life cycle and what that reveals about existing drug targets. We also discuss the future

  1. DIVISION OF DRUG ABUSE CONTROL A Project Evaluation

    E-Print Network [OSTI]

    Touretzky, David S.

    L,: . -'" -- . : NARCONON 1/1 DIVISION OF DRUG ABUSE CONTROL FA-48-72 74-007 75-009 A Project. In Relation to the Stated Objectives of the Division of Drug Abuse Control's Application .......... II ........·..··.· Appendix C - NARCONON - Division of Drug Abuse Control Contract ..·.............·..... Appendix D - Job

  2. Samples of Drug Testing Language Memorandum for Human Resources File

    E-Print Network [OSTI]

    Almor, Amit

    Samples of Drug Testing Language Memorandum for Human Resources File DATE: TO: Employee FROM: Supervisor RE: Drug Testing As you know, the position that you have been selected for requires that you pass a pre-employment drug and alcohol test. In addition to the pre-employment test, you will also be subject

  3. NARCSim An Agent-Based Illegal Drug Market Daniela Romano

    E-Print Network [OSTI]

    Romano, Daniela

    NARCSim An Agent-Based Illegal Drug Market Simulation Daniela Romano Computer Science University.Richmond@sheffield.ac.uk Abstract-- Combined forces interventions in the UK's illegal drug market can be designed and evaluated using a serious game, where the illegal drug market can be simulated using an Agent- Based Model

  4. Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes

    E-Print Network [OSTI]

    Chau, Ying

    2005-01-01T23:59:59.000Z

    We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

  5. Media's Positive and Negative Frames in Reporting Celebrity Deaths From Illegal Drug Overdoses Versus Prescription Drug Overdoses

    E-Print Network [OSTI]

    Wood, Michelle

    2011-12-31T23:59:59.000Z

    This study compared the celebrity illegal drug overdose deaths of River Phoenix, Chris Farley, and Brad Renfro to the prescription drug overdose deaths of Anna Nicole Smith, Heath Ledger, and Brittany Murphy. This research used quantitative...

  6. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01T23:59:59.000Z

    reputation-2009-2). Carter, Jimmy. 1977. “Drug Abuse Messagea presidential candidate in 1976, Jimmy Carter even adopted

  7. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01T23:59:59.000Z

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  8. Advances in Lymphatic Imaging and Drug Delivery

    SciTech Connect (OSTI)

    Nune, Satish K.; Gunda, Padmaja; Majeti, Bharat K.; Thallapally, Praveen K.; Laird, Forrest M.

    2011-09-10T23:59:59.000Z

    Cancer remains the second leading cause of death after heart disease in the US. While metastasized cancers such as breast, prostate, and colon are incurable, before their distant spread, these diseases will have invaded the lymphatic system as a first step in their progression. Hence, proper evaluation of the disease state of the lymphatics which drain a tumor site is crucial to staging and the formation of a treatment plan. Current lymphatic imaging modalities with visible dyes and radionucleotide tracers offer limited sensitivity and poor resolution; however, newer tools using nanocarriers, quantum dots, and magnetic resonance imaging promise to vastly improve the staging of lymphatic spread without needless biopsies. Concurrent with the improvement of lymphatic imaging agents, has been the development of drug carriers that can localize chemotherapy to the lymphatic system, thus improving the treatment of localized disease while minimizing the exposure of healthy organs to cytotoxic drugs. This review will focus on polymeric systems that have been developed for imaging and drug delivery to the lymph system, how these new devices improve upon current technologies, and where further improvement is needed.

  9. Time Off

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solidSynthesis ofwas publishedThree scientistsDepartmentTime Off

  10. Extension of the Isobolographic Approach to Interactions Studies between More than Two Drugs: Illustration

    E-Print Network [OSTI]

    Gelman, Andrew

    received the drugs separately or in various combinations. Drug infusion was stopped at the onset of maximal

  11. TECHNETIUM RETENTION IN WTP LAW GLASS WITH RECYCLE FLOW-SHEET DM10 MELTER TESTING VSL-12R2640-1 REV 0

    SciTech Connect (OSTI)

    Abramowitz, Howard [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Brandys, Marek [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Cecil, Richard [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; D'Angelo, Nicholas [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Matlack, Keith S. [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Muller, Isabelle S. [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Pegg, Ian L. [Energy Solutions, Federal EPC, Inc., Columbia, MD (United States); Callow, Richard A. [Energy Solutions, Federal EPC, Inc., Columbia, MD (United States); Joseph, Innocent

    2012-12-11T23:59:59.000Z

    Melter tests were conducted to determine the retention of technetium and other volatiles in glass while processing simulated Low Activity Waste (LAW) streams through a DM10 melter equipped with a prototypical off-gas system that concentrates and recycles fluid effiuents back to the melter feed. To support these tests, an existing DM10 system installed at Vitreous State Laboratory (VSL) was modified to add the required recycle loop. Based on the Hanford Tank Waste Treatment and Immobilization Plant (WTP) LAW off-gas system design, suitably scaled versions of the Submerged Bed Scrubber (SBS), Wet Electrostatic Precipitator (WESP), and TLP vacuum evaporator were designed, built, and installed into the DM10 system. Process modeling was used to support this design effort and to ensure that issues associated with the short half life of the {sup 99m}Tc radioisotope that was used in this work were properly addressed and that the system would be capable of meeting the test objectives. In particular, this required that the overall time constant for the system was sufficiently short that a reasonable approach to steady state could be achieved before the {sup 99m}Tc activity dropped below the analytical limits of detection. The conceptual design, detailed design, flow sheet development, process model development, Piping and Instrumentation Diagram (P&ID) development, control system design, software design and development, system fabrication, installation, procedure development, operator training, and Test Plan development for the new system were all conducted during this project. The new system was commissioned and subjected to a series of shake-down tests before embarking on the planned test program. Various system performance issues that arose during testing were addressed through a series of modifications in order to improve the performance and reliability of the system. The resulting system provided a robust and reliable platform to address the test objectives.

  12. Complete information below if not found on receipt #2 National Drug Code

    E-Print Network [OSTI]

    Aalberts, Daniel P.

    Complete information below if not found on receipt #2 National Drug Code Drug Name___________________________Drug Supply 5. National Drug Code (NDC) 6. Name of drug and strength 7. DAW code (if applicable) 8. Amount paid Tape Prescription Receipt #1 Here ­ No Staples DRUG CLAIM FORM 1. Please type or print clearly

  13. An analysis of retention issues of scientists, engineers, and program managers in the US Air Force

    E-Print Network [OSTI]

    Beck, Derek William, 1977-

    2005-01-01T23:59:59.000Z

    The United States Air Force is having a difficult time retaining their technical officers, who are critical to the success of their research, development, and acquisitions of major military and defense systems. A statistical ...

  14. Prediction of the saturated hydraulic conductivity from Brooks and Corey's water retention parameters

    E-Print Network [OSTI]

    Vrugt, Jasper A.

    's equation with Darcy's law [Burdine, 1953; Brutsaert, 1967]. The model proposed by Mualem [1976] represents is time consuming and expensive. In this study, we derive a simple closed-form equation that predicts

  15. Sociodemographic and drug use characteristics, sex behaviors, and motivations for drug use among HIV- seronegative, heterosexual, methamphetamine users in San Diego, CA

    E-Print Network [OSTI]

    Cheng, Wei-Woon Susan

    2009-01-01T23:59:59.000Z

    TL A Comparison of Injection Drug Users (IDU) vs. Non-IDU inDISSERTATIO Sociodemographic and Drug Use Characteristics,and Motivations for Drug Use among HIV-Seronegative,

  16. Drug addiction is a common problem in this country, especially for adolescents. The detrimental effects of exposure to addictive drugs during adolescence continue to

    E-Print Network [OSTI]

    Minnesota, University of

    Background Drug addiction is a common problem in this country, especially for adolescents. The detrimental effects of exposure to addictive drugs during adolescence continue to affect individuals throughout their lifetimes (Yucel, Lubman, Solowlj & Brewer, 2007). Understanding the nature of drug

  17. Alcohol, Drugs, and Accident Prevention (RC-371/-571) Course Description The role of alcohol and drugs and their relationship to accident causation will be examined. The problem

    E-Print Network [OSTI]

    Wu, Mingshen

    Alcohol, Drugs, and Accident Prevention (RC-371/-571) Course Description The role of alcohol and drugs and their relationship to accident causation will be examined. The problem of alcoholism and drug

  18. Title: Drug and Alcohol Policies --Drug-Free Workplace Code: 1-300-020

    E-Print Network [OSTI]

    Huang, Jianyu

    -free workplace, and, in the case of grantees who are individuals, by requiring each individual to certify to receiving a contract or grant from a federal agency. All grantees who fail to meet the drug-free workplace of the Act. Grantees are not required to make a certification in order to continue receiving funds under

  19. Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells

    SciTech Connect (OSTI)

    El-Awady, Raafat A., E-mail: relawady@sharjah.ac.ae [Pharmacology unit, Department of Cancer Biology, National, Cancer Institute, Cairo University, Fom El-Khalig, Cairo (Egypt); Department of Pharmacology and Pharmaceutics, College of Pharmacy, University of Sharjah, University City road, 27272 Sharjah (United Arab Emirates); Saleh, Ekram M. [Clinical Biochemistry and Molecular Biology unit, Department of Cancer Biology, National, Cancer Institute, Cairo University, Fom El-Khalig, Cairo (Egypt); Ezz, Marwa [College of Pharmacy, Cairo University, Cairo (Egypt); Elsayed, Abeer M. [Tissue Culture unit, Pathology Department, National Cancer Institute, Cairo University (Egypt)

    2011-09-15T23:59:59.000Z

    Celecoxib, an inhibitor of cyclooxygenase-2, is being investigated for enhancement of chemotherapy efficacy in cancer clinical trials. This study investigates the ability of cyclooxygenase-2 inhibitors to sensitize cells from different origins to several chemotherapeutic agents. The effect of the drug's mechanism of action and sequence of administration are also investigated. The sensitivity, cell cycle, apoptosis and DNA damage of five different cancer cell lines (HeLa, HCT116, HepG2, MCF7 and U251) to 5-FU, cisplatin, doxorubicin and etoposide {+-} celecoxib following different incubation schedules were analyzed. We found antagonism between celecoxib and the four drugs in the breast cancer cells MCF7 following all incubation schedules and between celecoxib and doxorubicin in all cell lines except for two combinations in HCT116 cells. Celecoxib with the other three drugs in the remaining four cell lines resulted in variable interactions. Mechanistic investigations revealed that celecoxib exerts different molecular effects in different cells. In some lines, it abrogates the drug-induced G2/M arrest enhancing pre-mature entry into mitosis with damaged DNA thus increasing apoptosis and resulting in synergism. In other cells, it enhances drug-induced G2/M arrest allowing time to repair drug-induced DNA damage before entry into mitosis and decreasing cell death resulting in antagonism. In some synergistic combinations, celecoxib-induced abrogation of G2/M arrest was not associated with apoptosis but permanent arrest in G1 phase. These results, if confirmed in-vivo, indicate that celecoxib is not a suitable chemosensitizer for breast cancer or with doxorubicin for other cancers. Moreover, combination of celecoxib with other drugs should be tailored to the tumor type, drug and administration schedule. - Graphical abstract: Display Omitted Highlights: > Celecoxib may enhance effects of anticancer drugs. > Its combination with four drugs was tested in five cancer cell lines. > It antagonized the effects of the four drugs in the breast cancer cell line MCF7. > Doxorubicin's cytotoxic effects were antagonized by celecoxib in four cell lines. > Cell cycle, apoptosis and DNA damage explain the different interactive effects.

  20. Final Report - Gas Retention and Release Tests Supporting the Concentrate Receipt Vessel (CRV-VSL-00002A/2B) Configuration

    SciTech Connect (OSTI)

    GUERRERO, HECTOR

    2004-09-01T23:59:59.000Z

    Gas Retention and Release (GR and R) tests were performed in the scaled Concentrate Receipt Vessel (CRV) Test Stand at the Savannah River National Laboratory to validate the capability of candidate Hybrid-Mixing systems for the CRV to safely release hydrogen during normal and upset conditions. Hydrogen is generated in the radioactive waste as a result of natural and plant processes and must not be allowed to accumulate above flammability limits. Two types of tests were conducted. Gas holdup tests determined the steady state amount of gas accumulated in the simulant under normal PJM only or PJM plus sparging conditions. Gas release tests determined what operating conditions are necessary to fully release gas after a steady state gas fraction of 4 per cent tank volume or more was reached in the simulant.

  1. "Smoking Cessation Interventions and Program Availability for Drug and Alcohol Addicted Low Income Populations in Substance Abuse Treatment"

    E-Print Network [OSTI]

    Arnold, Jonathan

    "Smoking Cessation Interventions and Program Availability for Drug and Alcohol Addicted Low Income. The first aim examines longitudinally the availability of EBTs for smoking among those seeking treatment for co-occurring substance abuse and explores the predictors of changes in service availability over time

  2. Drugs offshore: companies stepping up fight against hidden adversary

    SciTech Connect (OSTI)

    Redden, J.

    1986-01-01T23:59:59.000Z

    Oil companies worldwide are effectively fighting a growing nemesis, drug and alcohol abuse on offshore installations. It is estimated that companies are losing millions of dollars in lost productivity, accidents, and thefts caused by on-the-job use of illegal drugs. Some of the measures being employed to combat the use of such drugs, e.g., tight control, better communications, diversions for employees, and the use of sniffer dogs, are discussed.

  3. Peer Mentor Program Application The purpose of the Peer Mentor Program is to increase retention of Asian/Pacific American students at

    E-Print Network [OSTI]

    Peer Mentor Program Application The purpose of the Peer Mentor Program is to increase retention the college experience of the mentors, mentees and the rest of the campus community by the students' increased involvement and engagement with campus programs and resources. The commitment required of the Peer Mentors

  4. Revised By: Lucy Paltoo, AAC Retention Specialist & Mentor Program Coordinator Last Revised: January 2013 2013-2014 Peer Mentor Position Description

    E-Print Network [OSTI]

    Stephens, Graeme L.

    Revised By: Lucy Paltoo, AAC Retention Specialist & Mentor Program Coordinator Last Revised: January 2013 2013-2014 Peer Mentor Position Description Thank you for your interest in applying to be a Peer Mentor for the AAC Mentoring for Leadership program. The Peer Mentor is a volunteer staff member

  5. antithyroid drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  6. antidiabetic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  7. antiretroviral drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  8. acute cutaneous drug: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  9. antipsychotic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  10. adverse drug events: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  11. adverse drug event: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  12. antiepileptic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  13. antiarrhythmic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  14. antiinflammatory drugs nsaids: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  15. acute drug intoxication: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  16. adhd drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  17. antihypertensive drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  18. alternative drug interaction: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brenda Fenton 230 The Crystal Structures of Psoralen Cross-linked DNAs: Drug-dependent Formation of Biology and Medicine Websites Summary: 12;The Crystal Structures of Psoralen...

  19. Food and Drug Administration White Oak Campus Environmental Stewardshi...

    Office of Environmental Management (EM)

    Stewardship and Cost Savings FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus....

  20. antimalarial drug artemisinin: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Isolation of Artemisinin as Antimalarial Drugs from Artemisia annua L. Cultivated in Indonesia CiteSeer Summary: Abstract-- Malaria disease is endemic in developing countries like...

  1. act drug policies: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcoholic beverages. These standards conform to state and federal laws. The policy described in this brochure pertains to alcohol and other drug use behaviors in...

  2. anticancer drug analysis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    or preclinical development. Preeti Singh Sisodiya 2012-01-01 68 Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON Computer Technologies and Information Sciences...

  3. Drug representatives: Giving you lunch or stealing your soul?

    E-Print Network [OSTI]

    Higgins, Steven P

    2007-01-01T23:59:59.000Z

    with pharmaceutical representatives are too useful topharmaceutical sales representatives. JAMA. 1995 Apr 26;273(Drug representatives: Giving you lunch or stealing your

  4. Revealing a Novel Mode of Action for an Osteoporosis Drug

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to APS Science Highlights rss feed Revealing a Novel Mode of Action for an Osteoporosis Drug August 13, 2014 Bookmark and Share Schematic of mechanical testing apparatus...

  5. anticancer drug levels: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: Summary.-The effects of hormone and drug treatments on plasma prolactin (PRL) levels and mammary tumour growth were investigated in rats bearing continuously...

  6. antipsychotic drug treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    prognosis. ... Scott, Alexander Wesley 2010-01-01 45 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  7. antihypertensive drug treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    prognosis. ... Scott, Alexander Wesley 2010-01-01 28 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  8. anticancer drug treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    prognosis. ... Scott, Alexander Wesley 2010-01-01 48 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  9. animal drugs change: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to many antibiotics. In an increasing number of cases, vancomycin is the only treatment drug that remains effective. Because E. faecium was untreatable with practically all...

  10. animal drug availability: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to many antibiotics. In an increasing number of cases, vancomycin is the only treatment drug that remains effective. Because E. faecium was untreatable with practically all...

  11. antidepressant drug treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    prognosis. ... Scott, Alexander Wesley 2010-01-01 50 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  12. antiretroviral drug exposure: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SKILLS AQUIRED THROUGH Auerbach, Scott M. 2 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  13. antiretroviral drugs arvs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on (more) Wilson, Kinsley Rose 2009-01-01 4 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  14. antiretroviral drug combination: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    carrying various combinations Ahlers, Guenter 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  15. antidepressant drug design: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ylenedioxymethamphetamine (MDMA) also known as Ecstasy is a common recreational drug of abuse and reports of abuse of tricyclic antidepressants are also known. We report two cases...

  16. Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2007-01-01T23:59:59.000Z

    Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

  17. Intermittent Preventive Treatment (IPT) and the spread of drug ...

    E-Print Network [OSTI]

    2014-12-25T23:59:59.000Z

    drug resistant malaria. Miranda I. Teboh-Ewungkem, Olivia Prosper, Katharine Gurski, Carrie A. Manore, Angela Peace, and. Zhilan Feng. Abstract Intermittent ...

  18. In silico modeling to predict drug-induced phospholipidosis

    SciTech Connect (OSTI)

    Choi, Sydney S.; Kim, Jae S.; Valerio, Luis G., E-mail: luis.valerio@fda.hhs.gov; Sadrieh, Nakissa

    2013-06-01T23:59:59.000Z

    Drug-induced phospholipidosis (DIPL) is a preclinical finding during pharmaceutical drug development that has implications on the course of drug development and regulatory safety review. A principal characteristic of drugs inducing DIPL is known to be a cationic amphiphilic structure. This provides evidence for a structure-based explanation and opportunity to analyze properties and structures of drugs with the histopathologic findings for DIPL. In previous work from the FDA, in silico quantitative structure–activity relationship (QSAR) modeling using machine learning approaches has shown promise with a large dataset of drugs but included unconfirmed data as well. In this study, we report the construction and validation of a battery of complementary in silico QSAR models using the FDA's updated database on phospholipidosis, new algorithms and predictive technologies, and in particular, we address high performance with a high-confidence dataset. The results of our modeling for DIPL include rigorous external validation tests showing 80–81% concordance. Furthermore, the predictive performance characteristics include models with high sensitivity and specificity, in most cases above ? 80% leading to desired high negative and positive predictivity. These models are intended to be utilized for regulatory toxicology applied science needs in screening new drugs for DIPL. - Highlights: • New in silico models for predicting drug-induced phospholipidosis (DIPL) are described. • The training set data in the models is derived from the FDA's phospholipidosis database. • We find excellent predictivity values of the models based on external validation. • The models can support drug screening and regulatory decision-making on DIPL.

  19. Transdermal microconduits by microscission for drug delivery and sample acquisition

    E-Print Network [OSTI]

    Gonzalez, Salvador

    Background Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum ...

  20. Detection of illegal drugs using passive infrared sensing

    SciTech Connect (OSTI)

    Bennett, C.L.; Carter, M.R.; Fields, D.J.

    1996-04-12T23:59:59.000Z

    This report summarizes results on experiments testing the feasibility of detecting illegal drugs using passive infrared spectroscopy in the 8-13 micrometer spectral band.

  1. antimalarial drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 30 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  2. antidepressant drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 39 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  3. avoiding drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 23 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  4. Print Date: 6/30/2003 The Effects of Advertising on Customer Retention

    E-Print Network [OSTI]

    Faloutsos, Christos

    . We propose a two-period model in which an auctioneer sells one item in each time period using, since the higher the number of bidders, the higher the expected winning price and profitability in the auction. It is this tradeoff for the auctioneer between more consumers and a higher expected price versus

  5. Hyperpolarized Nanodiamond with Long Spin Relaxation Times

    E-Print Network [OSTI]

    Ewa Rej; Torsten Gaebel; Thomas Boele; David E. J. Waddington; David J. Reilly

    2015-02-22T23:59:59.000Z

    The use of hyperpolarized agents in magnetic resonance (MR), such as 13C-labeled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarizaton technique is the inherently short spin relaxation times, typically solid-state environment, exhibit relaxation times exceeding 1 hour. Combined with the already established applications of NDs in the life-sciences as inexpensive fluorescent markers and non-cytotoxic substrates for gene and drug delivery, these results extend the theranostic capabilities of nanoscale diamonds into the domain of hyperpolarized MR.

  6. Intracellular drug distribution-based targeting: Exploiting lysosomes to enhance the selectivity of drugs towards cancer cells

    E-Print Network [OSTI]

    Ndolo, Rosemary A.

    2012-08-31T23:59:59.000Z

    was found to induce marked tumor regression. The discovery of nitrogen mustard as a novel anticancer drug resulted in a great deal of optimism that cancer could finally be cured. A burst of research activity to develop new anticancer drugs therefore... of activity against normal cells. Indeed, many novel anticancer agents continue to be identified, but few find clinical utility due to unacceptable toxicity [17], a clear indicator that there is a need for a screening approach that can identify potent drugs...

  7. Lance water injection tests adjacent to the 281-3H retention basin at the Savannah River Site, Aiken, South Carolina

    SciTech Connect (OSTI)

    Freifeld, B.; Myer, L.; Moridis, G.; Cook, P.; James, A.; Pellerin, L.; Pruess, K.

    1996-09-01T23:59:59.000Z

    A pilot-scale field demonstration of waste isolation using viscous- liquid containment barriers has been planned for the 281-3H retention basin at the Savannah River Site, Aiken, SC. The 281-3H basin is a shallow retention/seepage basin contaminated mainly by radionuclides. The viscous-liquid containment barrier utilizes the permeation of liquid grout to either entomb the contaminants within a monolithic grout structure or to isolate the waste by drastically reducing the permeability, of the soils around the plume. A clear understanding of the hydrogeologic setting of the retention basin is necessary for proper design of the viscous liquid barrier. To aid in the understanding of the hydrogeology of the 281-3H retention basin, and to obtain critical parameters necessary for grout injection design, a series of tests were undertaken in a region immediately adjacent to the basin. The objectives of the LWIT were: 1. To evaluate the general performance of the Lance Injection Technique for grout emplacement at the site, including the range and upper limits of injection pressures, the flow rates applicable for site conditions, as well as the mechanical forces needed for lance penetration. 2. To obtain detailed information on the injectability of the soils immediately adjacent to the H-area retention basin. 3. To identify any high permeability zones suitable for injection and evaluate their spatial distribution. 4. To perform ground penetrating radar (GPR) to gain information on the structure of the soil column and to compare the results with LWIT data. This report will focus on results pertinent to these objectives.

  8. Drug interactions evaluation: An integrated part of risk assessment of therapeutics

    SciTech Connect (OSTI)

    Zhang, Lei; Reynolds, Kellie S.; Zhao, Ping [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States); Huang, Shiew-Mei, E-mail: shiewmei.huang@fda.hhs.go [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States)

    2010-03-01T23:59:59.000Z

    Pharmacokinetic drug interactions can lead to serious adverse events or decreased drug efficacy. The evaluation of a new molecular entity's (NME's) drug-drug interaction potential is an integral part of risk assessment during drug development and regulatory review. Alteration of activities of enzymes or transporters involved in the absorption, distribution, metabolism, or excretion of a new molecular entity by concomitant drugs may alter drug exposure, which can impact response (safety or efficacy). The recent Food and Drug Administration (FDA) draft drug interaction guidance ( (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072101.pdf)) highlights the methodologies and criteria that may be used to guide drug interaction evaluation by industry and regulatory agencies and to construct informative labeling for health practitioner and patients. In addition, the Food and Drug Administration established a 'Drug Development and Drug Interactions' website to provide up-to-date information regarding evaluation of drug interactions ( (http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm080499.htm)). This review summarizes key elements in the FDA drug interaction guidance and new scientific developments that can guide the evaluation of drug-drug interactions during the drug development process.

  9. Regulatory aspects of oncology drug safety evaluation: Past practice, current issues, and the challenge of new drugs

    SciTech Connect (OSTI)

    Rosenfeldt, Hans, E-mail: hans.rosenfeldt@fda.hhs.go [Division of Drug Oncology Products, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring MD, 20993 (United States); Kropp, Timothy; Benson, Kimberly [Division of Drug Oncology Products, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring MD, 20993 (United States); Ricci, M. Stacey [Division of Biologic Oncology Products, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring MD, 20993 (United States); McGuinn, W. David; Verbois, S. Leigh [Division of Drug Oncology Products, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring MD, 20993 (United States)

    2010-03-01T23:59:59.000Z

    The drug development of new anti-cancer agents is streamlined in response to the urgency of bringing effective drugs to market for patients with limited life expectancy. FDA's regulation of oncology drugs has evolved from the practices set forth in Arnold Lehman's seminal work published in the 1950s through the current drafting of a new International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) safety guidance for anti-cancer drug nonclinical evaluations. The ICH combines the efforts of the regulatory authorities of Europe, Japan, and the United States and the pharmaceutical industry from these three regions to streamline the scientific and technical aspects of drug development. The recent development of new oncology drug classes with novel mechanisms of action has improved survival rates for some cancers but also brings new challenges for safety evaluation. Here we present the legacy of Lehman and colleagues in the context of past and present oncology drug development practices and focus on some of the current issues at the center of an evolving harmonization process that will generate a new safety guidance for oncology drugs, ICH S9. The purpose of this new guidance will be to facilitate oncology drug development on a global scale by standardizing regional safety requirements.

  10. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01T23:59:59.000Z

    Policy Reform: How an Illegal ‘Safer Injection Room’ Led toof African-Americans became illegal, the rise of “punitiveby wealthy whites, such as illegal prescription drug use by

  11. Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery

    E-Print Network [OSTI]

    Bhatia, Sangeeta

    Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery By Ji nanoparticles and drug molecules can be co- encapsulated in liposomes to simultaneously perform multiple and luminescent porous silicon nanoparticles to overcome such problems,[5,6] although these more complicated

  12. Drug-Free Federal Workplace Testing Implementation Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-06T23:59:59.000Z

    The subject directive provides requirements and responsibilities for the implementation of a workplace program to test for the use of illegal drugs to facilitate the maintenance of a drug-free Federal workplace. In the course of the revision, the document number will change from DOE O 3792.3 to DOE O 343.1.

  13. Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance

    E-Print Network [OSTI]

    Hanson, Floyd B.

    Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance J. J. Westman-7045 USA Abstract A compartment model for the evolution of cancer subject to multiple chemotherapeutic agents is presented. The formulation accounts for the heterogeneous nature of cancer and drug resistance

  14. Blue MedicareRx (PDP)SM 2012 Comprehensive Drug List

    E-Print Network [OSTI]

    Oklahoma, University of

    Blue MedicareRx (PDP)SM 2012 Comprehensive Drug List PLEASE READ: THIS DOCUMENT CONTAINS DrugList Blue MedicareRx (PDP)SM 2012 Formulary (List of Covered Drugs) DrugList PLEASE READ. Blue MedicareRx (PDP) is a stand-alone prescription drug plan with a Medicare contract offered by HCSC

  15. Drug-Free Workplace Program UT-B Contracts Page 1 of 1

    E-Print Network [OSTI]

    Pennycook, Steve

    Drug-Free Workplace Program UT-B Contracts Sep 2012 Page 1 of 1 drug-free-workplace-ext-sep12 DRUG, the Seller and its subcontractors working on the project site must maintain a drug-free workplace program. (B) If the Seller is an out-of-state entity, the Company may upon request allow a drug-free workplace

  16. Drug Resistance Updates 15 (2012) 9097 Contents lists available at SciVerse ScienceDirect

    E-Print Network [OSTI]

    Levy, Doron

    2012-01-01T23:59:59.000Z

    Drug Resistance Updates 15 (2012) 90­97 Contents lists available at SciVerse ScienceDirect Drug Resistance Updates journal homepage: www.elsevier.com/locate/drup The dynamics of drug resistance Park, MD, USA a r t i c l e i n f o Keywords: Drug-dependent/independent resistance Drug scheduling

  17. Alendronate functionalized mesoporous hydroxyapatite nanoparticles for drug delivery

    SciTech Connect (OSTI)

    Li, Dongdong, E-mail: lidongchem@sina.cn [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China); Zhu, Yuntao; Liang, Zhiqiang [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China)

    2013-06-01T23:59:59.000Z

    Highlights: ? The synthesized mesoporous hydroxyapatite has nanostructure and bioactivity. ? The materials have high surface area and amino group. ? The materials show higher drug loading and slower release rate than pure HAP. - Abstract: Mesoporous nanosized hydroxyapatite (HAP) functionalized by alendronate (ALN) was synthesized using cationic surfactant CTAB as template. The structural, morphological and textural properties were fully characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and N{sub 2} adsorption/desorption. Then the obtained materials were performed as drug delivery carriers using ibuprofen (IBU) as a model drug to investigate their drug storage/release properties in simulated body fluid (SBF). The materials showed relatively slower release rate compared with HAP due to the ionic interaction between -NH{sub 3}{sup +} on the matrix and -COO{sup ?}belongs to IBU. The system provides a new concept for improving the drug loading or slowing down the release rate.

  18. Statistical Agent Based Modelization of the Phenomenon of Drug Abuse

    E-Print Network [OSTI]

    Di Clemente, Riccardo; 10.1038/srep00532

    2012-01-01T23:59:59.000Z

    We introduce a statistical agent based model to describe the phenomenon of drug abuse and its dynamical evolution at the individual and global level. The agents are heterogeneous with respect to their intrinsic inclination to drugs, to their budget attitude and social environment. The various levels of drug use were inspired by the professional description of the phenomenon and this permits a direct comparison with all available data. We show that certain elements have a great importance to start the use of drugs, for example the rare events in the personal experiences which permit to overcame the barrier of drug use occasionally. The analysis of how the system reacts to perturbations is very important to understand its key elements and it provides strategies for effective policy making. The present model represents the first step of a realistic description of this phenomenon and can be easily generalized in various directions.

  19. NRC drug-free workplace plan. Revision 1

    SciTech Connect (OSTI)

    NONE

    1997-11-01T23:59:59.000Z

    On September 15, 1986, President Reagan signed Executive Order 12564, establishing the goal of a Drug-Free Federal Workplace. The Order made it a condition of employment that all Federal employees refrain from using illegal drugs on or off duty. On July 11, 1987, Congress passed legislation affecting implementation of the Executive Order under Section 503 of the Supplemental Appropriations Act of 1987, Public Law 100-71 (the Act). The Nuclear Regulatory Commission first issued the NRC Drug Testing Plan to set forth objectives, policies, procedures, and implementation guidelines to achieve a drug-free Federal workplace, consistent with the Executive Order and Section 503 of the Act. Revision 1, titled, ``NRC Drug-Free Workplace Plan,`` supersedes the previous version and its supplements and incorporates changes to reflect current guidance from the Department of Justice, the Department of Health and Human Services, as well as other guidance.

  20. Hypoxic cell radiosensitizers: expectations and progress in drug development

    SciTech Connect (OSTI)

    Coleman, C.N.

    1985-02-01T23:59:59.000Z

    When misonidazole (MISO) was introduced into clinical trials there were great expectations that the cure rate of many tumors would be dramatically increased. The lack of efficacy of MISO discouraged further studies with hypoxic cell sensitizers. In recent years superior sensitizers SR 2508 and RO-03-8799 have been introduced into the clinic. SR 2508 is less neurotoxic than MISO, allowing more than three times the total amount of drug to be administered. Furthermore, based on the analysis of a patient's plasma pharmacokinetic profile, neurotoxicity may be largely avoidable. RO-03-8799 is superior in that it produces a higher sensitizer enhancement ratio than MISO for the same administered dose. Unlike with MISO and SR 2508, the dose of RO-03-8799 that can be administered is limited by acute toxicity with no cumulative toxicity having yet been encountered. Study design has improved and the expected clinical benefit from sensitizers has been clarified. Sensitizers, like particle radiation therapy and hyperthemia will, if successful, effect the rate of local tumor control, but cannot improve the cure rate of patients with preexisting metastatic disease. Taking into account the need to optimize reoxygenation, the various reasons for tumor radioresistance other than hypoxia, and the lower oxygen and sensitizer enhancement ratios at 200 cGy per fraction, it is likely that sensitizers will provide some clinical benefit for patients with selected tumor types.

  1. Maswadeh M Hamzah et al. / Drug Invention Today 2010, 2(2),155-159 Drug Invention Today Vol.2.Issue 2.February 2010 155-159

    E-Print Network [OSTI]

    Maswadeh M Hamzah et al. / Drug Invention Today 2010, 2(2),155-159 Drug Invention Today Vol.2.Issue of bioadhesivepolymersforlocalandsystemicdrugdeliveryformulations (1, 2). This is because these polymers can prolong the release of drug from dosage forms of the mucosa adhesive bond strength is essential for the successful application of bioadhesive drug delivery

  2. RIKEN Program for Drug Discovery and Medical Technology PlatformsRIKEN Program for Drug Discovery and Medical Technology Platforms Toshio Goto Program Director (D.Agr.)

    E-Print Network [OSTI]

    Fukai, Tomoki

    RIKEN Program for Drug Discovery and Medical Technology PlatformsRIKEN Program for Drug Discovery-2007, Associate Senior VP, Drug Discovery Research, Astellas. 2007-2009, Adviser, PGXIS. 2009-2010, Special Adviser, RIKEN, and 2010-present, Director, RIKEN Program for Drug Discovery and Medical Technology

  3. Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

    SciTech Connect (OSTI)

    Pereira, Claudia V.; Oliveira, Paulo J. [CNC—Center for Neuroscience and Cell Biology, University of Coimbra (Portugal)] [CNC—Center for Neuroscience and Cell Biology, University of Coimbra (Portugal); Will, Yvonne [Compound Safety Prediction, Pfizer Global Research and Development, Groton, CT (United States)] [Compound Safety Prediction, Pfizer Global Research and Development, Groton, CT (United States); Nadanaciva, Sashi, E-mail: sashi.nadanaciva@pfizer.com [Compound Safety Prediction, Pfizer Global Research and Development, Groton, CT (United States)] [Compound Safety Prediction, Pfizer Global Research and Development, Groton, CT (United States)

    2012-10-15T23:59:59.000Z

    Mitochondrial DNA (mtDNA) variations including single nucleotide polymorphisms (SNPs) have been proposed to be involved in idiosyncratic drug reactions. However, current in vitro and in vivo models lack the genetic diversity seen in the human population. Our hypothesis is that different cell strains with distinct mtDNA SNPs may have different mitochondrial bioenergetic profiles and may therefore vary in their response to drug-induced toxicity. Therefore, we used an in vitro system composed of four strains of mouse embryonic fibroblasts (MEFs) with mtDNA polymorphisms. We sequenced mtDNA from embryonic fibroblasts isolated from four mouse strains, C57BL/6J, MOLF/EiJ, CZECHII/EiJ and PERA/EiJ, with the latter two being sequenced for the first time. The bioenergetic profile of the four strains of MEFs was investigated at both passages 3 and 10. Our results showed that there were clear differences among the four strains of MEFs at both passages, with CZECHII/EiJ having a lower mitochondrial robustness when compared to C57BL/6J, followed by MOLF/EiJ and PERA/EiJ. Seven drugs known to impair mitochondrial function were tested for their effect on the ATP content of the four strains of MEFs in both glucose- and galactose-containing media. Our results showed that there were strain-dependent differences in the response to some of the drugs. We propose that this model is a useful starting point to study compounds that may cause mitochondrial off-target toxicity in early stages of drug development, thus decreasing the number of experimental animals used. -- Highlights: ? mtDNA SNPs may be linked to individual predisposition to drug-induced toxicity. ? CZECHII/EiJ and PERA/EiJ mtDNA was sequenced for the first time in this study. ? Strain-dependent mitochondrial capacity differences were measured. ? Strain-dependent differences in response to mitochondrial toxicants were observed.

  4. And Justice for All? Racial and Ethnic Disparities in Federal Drug Courts in California and the US

    E-Print Network [OSTI]

    Chen, Elsa; Nomura, Kevin

    2015-01-01T23:59:59.000Z

    Guideline Range of Sentence Drug Of- fense Cat- egorieswith regard to federal drug crime sentences in California.2003 Coef. e ß (SE) senting drug type, with crack, heroin,

  5. Charge Retention by Gold Clusters on Surfaces Prepared Using Soft Landing of Mass Selected Ions

    SciTech Connect (OSTI)

    Johnson, Grant E.; Priest, Thomas A.; Laskin, Julia

    2012-01-24T23:59:59.000Z

    Monodisperse gold clusters have been prepared on surfaces in different charge states through soft landing of mass-selected ions. Ligand-stabilized gold clusters were prepared in methanol solution by reduction of chloro(triphenylphosphine)gold(I) with borane tert-butylamine complex in the presence of 1,3-bis(diphenylphosphino)propane. Electrospray ionization was used to introduce the clusters into the gas-phase and mass-selection was employed to isolate a single ionic cluster species (Au11L53+, L = 1,3-bis(diphenylphosphino)propane) which was delivered to surfaces at well controlled kinetic energies. Using in-situ time of flight secondary ion mass spectrometry (TOF-SIMS) it is demonstrated that the Au11L53+ cluster retains its 3+ charge state when soft landed onto the surface of a 1H,1H,2H,2H-

  6. Commercial potential for thermal & magnetic sensitive polymer in drug delivery applications

    E-Print Network [OSTI]

    Edward, Jonathan M. (Jonathan Mark)

    2008-01-01T23:59:59.000Z

    Thermal and magnetically sensitive polymers are a new class of materials with unique properties suitable for applications in drug delivery. Specifically, these polymers can be combined with a drug reservoir to make a drug ...

  7. Structure-based drug mechanism study and inhibitor design targeting tuberculosis 

    E-Print Network [OSTI]

    Wang, Feng

    2009-05-15T23:59:59.000Z

    The increase of multi-drug resistant and extensively drug resistant tuberculosis (TB) cases makes it urgent to develop a new generation of TB drugs to counter resistance and shorten treatment. Structural biology, which ...

  8. The Drug Evaluation and Classification Program in the state of Texas: a validation study

    E-Print Network [OSTI]

    Walden, Troy Duane

    2005-08-29T23:59:59.000Z

    to determine if the procedures are reliable and whether a drug recognition expert (DRE) can properly apply the DECP procedures to consistently identify the drug category and have that opinion supported by toxicology. A total of 324 enforcement drug influence...

  9. Recovery from drug dependence : experiences of service users in a Christian faith-based agency 

    E-Print Network [OSTI]

    Jinadu, Comfort Ablavi

    2012-11-28T23:59:59.000Z

    Research in the field of drug dependence and recovery emphasises the need for more understanding of the concept of recovery from dependent drug use. This study explored the ways in which dependent drug users recover from ...

  10. Phencyclidine Intoxication and Adverse Effects: A Clinical and Pharmacological Review of an Illicit Drug

    E-Print Network [OSTI]

    Bey, Tareg; Patel, Anar

    2007-01-01T23:59:59.000Z

    Management of Poisoning and Drug Overdose. Philadelphia,patterns seen in street drug analysis. Clin Toxicol 1976; 9:Poklis A, Maginn D, Barr JL. Drug findings in ‘Driving Under

  11. Access to drug abuse treatment under Treatment on Demand policy in San Francisco

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    Wenger, L.D. ; Rosenbaum, M. Drug treatment on demand—not.J. Psychoactive Drugs 19. Yancovitz, S.R. ; Des Jarlais,332. 21. Office of National Drug Control Policy. National

  12. An In-situ materials analysis particle probe (MAPP) diagnostic to study particle density control and hydrogenic fuel retention in NSTX

    SciTech Connect (OSTI)

    Allain, Jean Paul [University of Illinois at Urbana-Champaign] (ORCID:000000031348262X)

    2014-09-05T23:59:59.000Z

    A new materials analysis particle probe (MAPP) was designed, constructed and tested to develop understanding of particle control and hydrogenic fuel retention in lithium-based plasma-facing surfaces in NSTX. The novel feature of MAPP is an in-situ tool to probe the divertor NSTX floor during LLD and lithium-coating shots with subsequent transport to a post-exposure in-vacuo surface analysis chamber to measure D retention. In addition, the implications of a lithiated graphite-dominated plasma-surface environment in NSTX on LLD performance, operation and ultimately hydrogenic pumping and particle control capability are investigated in this proposal. MAPP will be an invaluable tool for erosion/redeposition simulation code validation.

  13. E-Print Network 3.0 - arsenic-based antineoplastic drugs Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Health Care Settings" (http... Group 1 Carcinogens, Chemotherapy Waste and other Hazardous Drug...

  14. E-Print Network 3.0 - antiparasitic drug nitazoxanide Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

  15. Drug Court Effectiveness: A Review of California Evaluation Reports, 1995-1999

    E-Print Network [OSTI]

    Guydish, Joseph R PhD; Wolfe, Ellen; Tajima, Barbara; Woods, William J

    2006-01-01T23:59:59.000Z

    Evaluation qfthe Oakland Drug Court Afur ?ue Ycan. Onklsnd.39; Journal ¢JP:ydIurclive Drugs 378 - -. ~z. ~. ;- Sa;;n"IDrug Courl::

  16. Magnetically Triggered Nanocomposite Membranes: A Versatile Platform for Triggered Drug Release

    E-Print Network [OSTI]

    Hoare, Todd

    Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on?off drug release upon application (and removal) ...

  17. Dissolved Nutrient Retention Dynamics in River Networks: A Modeling Investigation of Transient Flow and Scale Effects

    SciTech Connect (OSTI)

    Ye, Sheng; Covino, Timothy P.; Sivapalan, Murugesu; Basu, Nandita; Li, Hongyi; Wang, Shaowen

    2012-06-30T23:59:59.000Z

    In this paper, we use a dynamic network flow model, coupled with a transient storage zone biogeochemical model, to simulate dissolved nutrient removal processes at the channel network scale. We have explored several scenarios in respect of the combination of rainfall variability, and the biological and geomorphic characteristics of the catchment, to understand the dominant controls on removal and delivery of dissolved nutrients (e.g., nitrate). These model-based theoretical analyses suggested that while nutrient removal efficiency is lower during flood events compared to during baseflow periods, flood events contribute significantly to bulk nutrient removal, whereas bulk removal during baseflow periods is less. This is due to the fact that nutrient supply is larger during flood events; this trend is even stronger in large rivers. However, the efficiency of removal during both periods decreases in larger rivers, however, due to (i) increasing flow velocities and thus decreasing residence time, and (ii) increasing flow depth, and thus decreasing nutrient uptake rates. Besides nutrient removal processes can be divided into two parts: in the main channel and in the hyporheic transient storage zone. When assessing their relative contributions the size of the transient storage zone is a dominant control, followed by uptake rates in the main channel and in the transient storage zone. Increasing size of the transient storage zone with downstream distance affects the relative contributions to nutrient removal of the water column and the transient storage zone, which also impacts the way nutrient removal rates scale with increasing size of rivers. Intra-annual hydrologic variability has a significant impact on removal rates at all scales: the more variable the streamflow is, compared to mean discharge, the less nutrient is removed in the channel network. A scale-independent first order uptake coefficient, ke, estimated from model simulations, is highly dependent on the relative size of the transient storage zone and how it changes in the downstream direction, as well as the nature of hydrologic variability.

  18. Photodynamic Therapy of the Canine Prostate: Intra-arterial Drug Delivery

    SciTech Connect (OSTI)

    Moore, Ronald B. [University of Alberta, Department of Surgery (Canada)], E-mail: rmoore@cha.ab.ca; Xiao, Zhengwen [University of Alberta, Cross Cancer Institute, Department of Oncology (Canada); Owen, Richard J.; Ashforth, Robert [University of Alberta, Department of Radiology and Diagnostic Imaging (Canada); Dickey, Dwayne [University of Alberta, Department of Electric Engineering (Canada); Helps, Cathy [Cross Cancer Institute, Department of Nuclear Medicine and Oncologic Imaging (Canada); Tulip, John [University of Alberta, Department of Electric Engineering (Canada)

    2008-01-15T23:59:59.000Z

    Purpose. Interstitial photodynamic therapy (PDT) selectively destroys tissue targeted with a photosensitizer and then exposed to light of a specific wavelength. We report a novel delivery method-intra-arterial drug delivery for PDT of the prostate-in a canine model.Methods. To evaluate drug distribution, the prostatovesical artery was selectively cannulated and photosensitizers alone or in conjunction with 99m-technetium-labeled macro-aggregated albumin ({sup 99m}Tc-MAA) were injected via a 3 Fr microcatheter in 8 animals. One dog was followed for 3 months to determine tolerance and toxicity. The remaining animals were euthanized and imaged with whole-body single photon emission CT and gamma counting for radioactivity distribution. Photosensitizer distribution was further analyzed by fluorescence confocal microscopy and tissue chemical extraction. To evaluate PDT, the photosensitizer QLT0074 was infused in 3 animals followed by interstitial illumination with 690 nm laser light. Results. Intra-arterial infusion selectively delivered drugs to the prostate, with both radioactivity and photosensitizer levels significantly higher (up to 18 times) than in the surrounding organs (i.e., rectum). With unilateral injection of {sup 99m}Tc-MAA, only the injected half of the prostate showed activity whereas bilateral administration resulted in drug delivery to the entire prostate. PDT resulted in comprehensive damage to the prostate without severe complications or systemic toxicity. Conclusion. Injection of radiolabeled MAA into the prostatovesical artery results in distribution within the prostate with negligible amounts reaching the adjacent organs. PDT also demonstrates selective damage to the prostate, which warrants clinical application in targeted prostate therapies.

  19. Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery

    E-Print Network [OSTI]

    Tan, Mei Chee

    The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

  20. Cellular responses against DNA damaged by platinum anticancer drugs

    E-Print Network [OSTI]

    Jung, Yongwon, 1977-

    2005-01-01T23:59:59.000Z

    The anticancer activity of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is mediated by their ability to attack DNA such that generated adducts trigger numerous cellular responses. A better understanding ...

  1. Needle-free drug delivery using shock wave techniques

    E-Print Network [OSTI]

    Pavlov, Atanas (Atanas Ivanov)

    2006-01-01T23:59:59.000Z

    A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

  2. Streamlining data management in drug product commercialization and manufacturing

    E-Print Network [OSTI]

    Anderson, Spencer C. (Spencer Clark)

    2014-01-01T23:59:59.000Z

    Effective execution and alignment of data management across development and manufacturing teams is essential for Amgen's Drug Product Technology group to realize its main goals of shortening the development timeline and ...

  3. A fully implantable intracochlear drug delivery device : development and characterization

    E-Print Network [OSTI]

    Swan, Erin Eileen Leary, 1976-

    2009-01-01T23:59:59.000Z

    In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

  4. Near-infrared-actuated devices for remotely controlled drug delivery

    E-Print Network [OSTI]

    Timko, Brian P.

    A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage ...

  5. Rethinking drug policy: an integrity preserving compromise position

    E-Print Network [OSTI]

    Crispino, Azzurra

    2006-10-30T23:59:59.000Z

    The "War on Drugs" has been raging for twenty years without resolution. This work attempts to provide a compromise position between the prohibitionists and the legalizers that preserves the integrity of both positions. This compromise position...

  6. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  7. antidiabetic drugs present: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    data to perform a number of econometric studies to assess the health and economic impacts of new drug development and use. I hypothesize that people may obtain several kinds...

  8. Alcohol, Tobacco, and Other Drug Use in Illinois: Prevalence

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    Assessment Program. Rod R. Blagojevich, Governor #12;#12;Alcohol, Tobacco, and Other Drug Use in Illinois by the federal Office of Management and Budget. Theodora Binion-Taylor, Associate Director 100 West Randolph

  9. adherence drug concentrations: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    abuse.Medication Adherence in HIV seropositive adults was associated with current drug abuseabuse, length of HIV illness, or number of years on HIV medications. 2007-01-01 11...

  10. antiretroviral drug fosamprenavir: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (0.08 m... Brouwers, Joachim 2006-10-25 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  11. Biosynthetic engineering for the assembly of better drugs

    E-Print Network [OSTI]

    Yadav, Vikramaditya Ganapati

    2013-01-01T23:59:59.000Z

    The declining prospects of innovator pharmaceutical companies have been attributed to their inability to discover leads that bind to novel protein domains. All of the 21,000-odd drug products that have ever been approved ...

  12. Stimuli Responsive Polymers for Enhanced Drug Release Applications

    E-Print Network [OSTI]

    Tam, Michael K. C.

    This talk will focus on the development of polymeric nano-structured systems for drug and gene delivery applications. Two major classes of polymer systems will be considered; namely poly(ethylene-oxide-b-propylene-oxide- ...

  13. Annual Report 2010 Department of Drug and Natural Product Synthesis

    E-Print Network [OSTI]

    Compounds University PET-Diagnostics Pharmacy SSAO- Drug University of Inhibitors Research Teaching Appl.730; Category Chemistry; Inorganic&Nuclear: Rank 16/40] B. Datterl, N. Tröstner, D. Kucharski, W. Holzer (2010

  14. Microcapsule drug delivery device for treatment of glioblastoma multiforme

    E-Print Network [OSTI]

    Scott, Alexander Wesley

    2010-01-01T23:59:59.000Z

    Controlled-release drug delivery systems are capable of treating debilitating diseases, including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. ...

  15. A Key Target for Diabetes Drugs | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor,...

  16. Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release

    E-Print Network [OSTI]

    Singh, Neetu

    Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we ...

  17. Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

    E-Print Network [OSTI]

    Tong, Rong

    We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, ...

  18. Biocompatibility of an implantable ophthalmic drug delivery device

    E-Print Network [OSTI]

    Cohen, Sarah J. (Sarah Jennifer)

    2007-01-01T23:59:59.000Z

    Diseases of the posterior eye present clinicians with a treatment challenge mainly due to the region's inaccessible location. Several drugs, including those available for the treatment of exudative age-related macular ...

  19. antiangiogenic drug assessed: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of 18 novel, anti-angiogenic 17- to 20-amino acid peptides Popel, Aleksander S. 10 Assessing malaria drug resistance in US military areas of operation using microarrays. Biology...

  20. Comparison of phenanthriplatin, a novel monofunctional platinum based anticancer drug candidate, with cisplatin, a classic bifunctional anticancer drug

    E-Print Network [OSTI]

    Li, Meiyi, S.M. Massachusetts Institute of Technology

    2012-01-01T23:59:59.000Z

    Nucleotide excision repair, a DNA repair mechanism, is the major repair pathway responsible for removal of platinum-based anticancer drugs. In this study, 146 bp duplexes were prepared containing either a site-specific ...

  1. Carcinogenesis and Inflammatory Effects of Plutonium-Nitrate Retention in an Exposed Nuclear Worker and Beagle Dogs.

    SciTech Connect (OSTI)

    Nielsen, Christopher E.; Wang, Xihai; Robinson, Robert J.; Brooks, Antone L.; Lovaglio, Jamie A.; Patton, Kristin M.; McComish, Stacey; Tolmachev, Sergei Y.; Morgan, William F.

    2014-01-01T23:59:59.000Z

    The genetic and inflammatory response pathways elicited following plutonium exposure in archival lung tissue of an occupationally exposed human and experimentally exposed beagle dogs were investigated. These pathways include: tissue injury, apoptosis and gene expression modifications related to carcinogenesis and inflammation. In order to determine which pathways are involved, multiple lung samples from a plutonium exposed worker (Case 0269), a human control (Case 0385), and plutonium exposed beagle dogs were examined using histological staining and immunohistochemistry. Examinations were performed to identify target tissues at risk of radiation-induced fibrosis, inflammation, and carcinogenesis. Case 0269 showed interstitial fibrosis in peripheral and subpleural regions of the lung, but no pulmonary tumors. In contrast, the dogs with similar and higher doses showed pulmonary tumors primarily in brochiolo-alveolar, peripheral and subpleural alveolar regions. The TUNEL assay showed slight elevation of apoptosis in tracheal mucosa, tumor cells, and nuclear debris was present in the inflammatory regions of alveoli and lymph nodes of both the human and the dogs. The expression of apoptosis and a number of chemokine/cytokine genes was slightly but not significantly elevated in protein or gene levels compared to that of the control samples. In the beagles, mucous production was increased in the airway epithelial goblet cells and glands of trachea, and a number of chemokine/cytokine genes showed positive immunoreactivity. This analysis of archival tissue from an accidentally exposed worker and in a large animal model provides valuable information on the effects of long-term retention of plutonium in the respiratory tract and the histological evaluation study may impact mechanistic studies of radiation carcinogenesis.

  2. Drug testing Example for Conditional Probability and Bayes Theorem Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    for an illegal drug is such that it is 98% accurate in the case of a user of that drug (e.g. it produces and the test is positive. What is the probability that the tested individual uses this illegal drug? What

  3. Managing high-bandwidth real-time data storage

    SciTech Connect (OSTI)

    Bigelow, David D. [Los Alamos National Laboratory; Brandt, Scott A [Los Alamos National Laboratory; Bent, John M [Los Alamos National Laboratory; Chen, Hsing-Bung [Los Alamos National Laboratory

    2009-09-23T23:59:59.000Z

    There exist certain systems which generate real-time data at high bandwidth, but do not necessarily require the long-term retention of that data in normal conditions. In some cases, the data may not actually be useful, and in others, there may be too much data to permanently retain in long-term storage whether it is useful or not. However, certain portions of the data may be identified as being vitally important from time to time, and must therefore be retained for further analysis or permanent storage without interrupting the ongoing collection of new data. We have developed a system, Mahanaxar, intended to address this problem. It provides quality of service guarantees for incoming real-time data streams and simultaneous access to already-recorded data on a best-effort basis utilizing any spare bandwidth. It has built in mechanisms for reliability and indexing, can scale upwards to meet increasing bandwidth requirements, and handles both small and large data elements equally well. We will show that a prototype version of this system provides better performance than a flat file (traditional filesystem) based version, particularly with regard to quality of service guarantees and hard real-time requirements.

  4. Nano-Sensor and Circuit Design for Anti-Cancer Drug Detection

    E-Print Network [OSTI]

    De Micheli, Giovanni

    in the case of some pharmacological treatments based on drug regimens, such as anti-cancer drug therapies [2]. Etoposide is a widely used anti-cancer drug, administered for the treatment of many kinds of tumours [3, 4Nano-Sensor and Circuit Design for Anti-Cancer Drug Detection S. Sara Ghoreishizadeh, Camilla Baj

  5. Ronald: A Domain-Specific Language to study the interactions between malaria infections and drug

    E-Print Network [OSTI]

    McBurney, Peter

    Ronald: A Domain-Specific Language to study the interactions between malaria infections and drug kills more than 1 million peo- ple a year, mostly children in sub-Saharan Africa. Antimalarial drug-Specific Language to model the fundamental forces driving antimalarial drug resistance including drug

  6. Employee Drug and Alcohol Abuse Policy #CofC.HR.DA.03 Revised 12/2001

    E-Print Network [OSTI]

    Kasman, Alex

    Policy Employee Drug and Alcohol Abuse Policy #CofC.HR.DA.03 Revised 12/2001 The Drug-Free Schools and Communities Act The Drug-Free School and Communities Act, Public Law 101-226, requires that as a condition, or distribution of illicit drugs and alcohol by students and employees. The College of Charleston has

  7. Topoisomerase II-Drug Interaction Domains: Identification of Substituents on Etoposide That Interact with the Enzyme

    E-Print Network [OSTI]

    Berkowitz, David

    Topoisomerase II-Drug Interaction Domains: Identification of Substituents on Etoposide chemotherapeutic agents used for the treatment of human cancers. The drug kills cells by inhibiting the ability, and a pendent ring (E-ring) at the C1 position. Although drug-enzyme contacts, as opposed to drug

  8. 276 Drug-FreePolicy University of Kentucky 2008-2009 Undergraduate Bulletin

    E-Print Network [OSTI]

    MacAdam, Keith

    276 Drug-FreePolicy University of Kentucky 2008-2009 Undergraduate Bulletin Drug-Free Policy Policy Statement as a Drug-Free Institution The University of Kentucky is committed to providing a healthy and safe to the unlawful possession, use, dispensa- tion, distribution or manufacture of alcohol or illicit drugs. Conduct

  9. Suppressive Drug Interactions between Antifungals Marjon G.J. de Vos1 and Tobias Bollenbach1,*

    E-Print Network [OSTI]

    Bulyk, Martha L.

    Suppressive Drug Interactions between Antifungals Marjon G.J. de Vos1 and Tobias Bollenbach1,* 1IST a systematic study of drug interactions be- tween antifungal compounds. Suppressive drug interactions occur. When two drugs are combined, they may interact synergistically or antago- nistically; for synergistic

  10. Drug-evoked synaptic plasticity and addictive behavior, a causal relationship?

    E-Print Network [OSTI]

    Fukai, Tomoki

    Drug-evoked synaptic plasticity and addictive behavior, a causal relationship? Christian Luescher principal interest is on drug reward and how exposure to addictive substances can change behavior in rodent models of addiction. "Drug-evoked synaptic plasticity" has emerged as a mechanism underlying drug

  11. Tailored drug release from biodegradable stent coatings based on hybrid polyurethanes

    E-Print Network [OSTI]

    Mather, Patrick T.

    Tailored drug release from biodegradable stent coatings based on hybrid polyurethanes Qiongyu Guo a 2009 Keywords: POSS Biodegradable polymer Drug delivery Drug-eluting stents Highly adjustable and precisely controllable drug release from a biodegradable stent coating was achieved using a unique family

  12. Updated 2011-12 HEALTH AND BEHAVIORAL RISKS OF ALCOHOL AND DRUG USE

    E-Print Network [OSTI]

    Marsh, David

    Updated 2011-12 HEALTH AND BEHAVIORAL RISKS OF ALCOHOL AND DRUG USE The negative physical and mental effects of the use of alcohol and other drugs are well documented. Use of these drugs may cause including depression, psychosis, and severe anxiety. Risks associated with specific drugs are described

  13. DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL DATA

    E-Print Network [OSTI]

    Zeng, Jianyang "Michael"

    DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL.edu.cn Corresponding author In silico prediction of unknown drug-target interactions (DTIs) has become a popular tool for drug repositioning and drug development. A key challenge in DTI prediction lies in integrating multiple

  14. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

    E-Print Network [OSTI]

    Xu, Jinghai J.

    Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to inadequacy of current preclinical screening assays, but recently established rodent models utilizing bacterial LPS co-administration ...

  15. The use of carbon stable isotope ratios in drugs characterization

    SciTech Connect (OSTI)

    Magdas, D. A., E-mail: gabriela.cristea@itim-cj.ro; Cristea, G., E-mail: gabriela.cristea@itim-cj.ro; Bot, A., E-mail: gabriela.cristea@itim-cj.ro; Mirel, V., E-mail: gabriela.cristea@itim-cj.ro [National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Str., 400293 Cluj-Napoca (Romania)

    2013-11-13T23:59:59.000Z

    Isotopic Ratio Mass Spectrometry (IRMS) is an effective toll to be used for drug product authentication. The isotopic composition could be used to assist in the differentiation between batches of drugs and assist in the identification of counterfeit materials on the market. Only two factors affect the isotopic ratios in pharmaceutical components: the isotopic composition of the raw materials and the synthetic processes performed upon them. Counterfeiting of pharmaceutical drugs threatens consumer confidence in drug products companies' economical well-being. In this preliminary study, the analyzed samples consist in two types of commercially available analgesics, which were purchases from Romanian pharmacies. Differences in ?{sup 13}C between batches from ?29.7 to ?31.6% were observed, demonstrating that this method can be used to differentiate among individual drug batches and subsequently identify counterfeits on the market. On the other hand, carbon isotopic ratios differences among producers were recorded, the variations being between ?31.3 to ?34.9% for the same type of analgesic, but from different manufactures.

  16. Alcohol and Drug Abuse Education Programs The University has developed a program to prevent the illicit use of drugs and the abuse of

    E-Print Network [OSTI]

    Escher, Christine

    Alcohol and Drug Abuse Education Programs The University has developed a program to prevent the illicit use of drugs and the abuse of alcohol by students and employees. The program provides services related to drug use and abuse including dissemination of informational materials, educational programs

  17. Why is the drug praziquantel effective in the treatment of parasitic flatworms? Praziquantel (PZQ) is the drug most commonly used in humans and livestock to

    E-Print Network [OSTI]

    Minnesota, University of

    Why is the drug praziquantel effective in the treatment of parasitic flatworms? Praziquantel (PZQ) is the drug most commonly used in humans and livestock to fight the disease schistosomiasis, an infection.S., et al, 1983; Ismail M. et al, 1999). There is evidence that the mechanism of the drug has to do

  18. 2013-2014 Annual Notification of Alcohol and Other Drug Information Page 1 2013-2014 Annual Notification of Alcohol and Other Drug Information

    E-Print Network [OSTI]

    Tullos, Desiree

    2013-2014 Annual Notification of Alcohol and Other Drug Information Page 1 2013-2014 Annual Notification of Alcohol and Other Drug Information OSU is required by law to notify annually all students, staff, and faculty of alcohol and other drug policies, sanctions, and risks associated with use

  19. Separation of peptides from myoglobin enzymatic digests by RPLC. Influence of the mobile-phase composition and the pressure on the retention and separation

    SciTech Connect (OSTI)

    Marchetti, Nicola [University of Tennessee, Knoxville (UTK); Guiochon, Georges A [ORNL

    2005-06-01T23:59:59.000Z

    The influence of the mobile-phase composition and the pressure on the chromatographic separation of the peptides from the enzymatic digest of myoglobin was studied under linear conditions. The retention behavior of these tryptic peptides was measured under isocratic conditions with different mobile-phase compositions, ranging from 9 to 28% (v/v) acetonitrile in 0.1% (v/v) aqueous trifluoroacetic acid. The effect of the pressure was studied by analyzing the separation of the tryptic peptides under different average column pressures between 14 and 220 bar, at 13, 20, and 26% (v/v) acetonitrile. The differences between the partial molar volumes of these peptides in the stationary and mobile phases were derived from these results. All the measurements were performed on a 10-cm-long C{sub 18}-bonded, end-capped monolithic column. The results obtained illustrate the highly complicated behavior of the complex peptide mixtures afforded by tryptic digestion. The capacity factors of the analyzed peptides do not depend linearly on the acetonitrile concentration but follow exactly a quadratic relationship. The adsorption changes of partial molar volumes are in good agreement with other literature data. The consequences of the influence of the average column pressure (hence of the flow rate) on the column phase ratio and on the retention factors of the peptides are discussed. The retention pattern of the complex mixture is affected by both the mobile-phase composition and the pressure, and the resolution of certain peptide pairs is so much affected by the pressure that inversions in the elution order of some pairs are observed.

  20. X-ray Spectroscopy for Quality Control of Chemotherapy Drugs

    SciTech Connect (OSTI)

    Greaves, E. D.; Barros, H.; Bermudez, J.; Sajo-Bohus, L. [Universidad Simon Bolivar, Apartado 89000, Caracas 1080A (Venezuela); Angeli-Greaves, M. [Universidad Central de Venezuela, Apartado 90373 Caracas 1083A (Venezuela)

    2007-10-26T23:59:59.000Z

    We develop a method, employing Compton peak standardization and the use of matrix-matched spiked samples with Total Reflection X-ray Fluorescence (TXRF), for the determination of platinum plasma concentrations of patients undergoing chemotherapy with Pt-bearing drugs. Direct blood plasma analysis attains Pt detection limits of 70 ng/ml. Measurement results of prescribed drug doses are compared to achieved blood Pt concentrations indicating a lack of expected correlations. Direct analysis of Pt-containing infused drugs from a variety of suppliers indicates cases of abnormal concentrations which raises quality control issues. We demonstrate the potential usefulness of the method for pharmacokinetic studies or for routine optimization and quality control of Pt chemotherapy treatments.

  1. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)

    1993-01-01T23:59:59.000Z

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  2. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02T23:59:59.000Z

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  3. A numerical study of the phase behaviors of drug particle/star triblock copolymer mixtures in dilute solutions for drug carrier application

    SciTech Connect (OSTI)

    Wang, Shanhui; Tong, Chaohui; Zhu, Yuejin, E-mail: zhuyuejin@nbu.edu.cn [Department of Physics, Ningbo University, Ningbo 315211 (China)] [Department of Physics, Ningbo University, Ningbo 315211 (China)

    2014-04-14T23:59:59.000Z

    The complex microstructures of drug particle/ABA star triblock copolymer in dilute solutions have been investigated by a theoretical approach which combines the self-consistent field theory and the hybrid particle-field theory. Simulation results reveal that, when the volume fraction of drug particles is smaller than the saturation concentration, the drug particle encapsulation efficiency is 100%, and micelle loading capacity increases with increasing particle volume fraction. When the volume fraction of drug particles is equal to the saturation concentration, the micelles attain the biggest size, and micelle loading capacity reaches a maximum value which is independent of the copolymer volume fraction. When the volume fraction of drug particles is more than the saturation concentration, drug particle encapsulation efficiency decreases with increasing volume fraction of drug particles. Furthermore, it is found that the saturation concentration scales linearly with the copolymer volume fraction. The above simulation results are in good agreement with experimental results.

  4. Scaling Laws for Reduced-Scale Tests of Pulse Jet Mixing Systems in Non-Newtonian Slurries: Gas Retention and Release Behavior

    SciTech Connect (OSTI)

    Stewart, Charles W.; Meyer, Perry A.; Kurath, Dean E.; Barnes, Steven M.

    2006-03-02T23:59:59.000Z

    The Waste Treatment Plant (WTP) under construction at the Hanford Site will use pulse jet mixer (PJM) technology for mixing and gas retention control applications in tanks expected to contain waste slurries exhibiting a non-Newtonian rheology. This paper presents the results of theoretical and experimental studies performed to establish the methodology to perform reduced-scale gas retention and release tests with PJM systems in non-Newtonian fluids with gas generation. The technical basis for scaled testing with unsteady jet mixing systems in gas-generating non-Newtonian fluids is presented in the form of a bubble migration model that accounts for the gas generation rate, the average bubble rise velocity, and the geometry of the vessel. Scaling laws developed from the model were validated with gas holdup and release tests conducted at three scales: large scale, 1/4 scale, and 1/9 scale. Experiments were conducted with two non-Newtonian simulants with in-situ gas generation by decomposition of hydrogen peroxide. The data were compared non-dimensionally, and the important scale laws were examined. From these results, scaling laws are developed which allow the design of mixing systems at a reduced scale.

  5. Drug addiction encompasses a relapsing cycle of intoxi-cation, bingeing, withdrawal and craving that results in

    E-Print Network [OSTI]

    Homes, Christopher C.

    Drug addiction encompasses a relapsing cycle of intoxi- cation, bingeing, withdrawal and craving that results in excessive drug use despite adverse consequences (FIG. 1). Drugs that are abused by humans) -- a syndrome that is char- acterized by attributing excessive salience to the drug and drug-related cues

  6. Optimisation of cancer drug treatments using cell population dynamics

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Optimisation of cancer drug treatments using cell population dynamics Fr´ed´erique Billy1 , Jean. The constraints at stake, met everyday in the clinic of cancers, are related mainly to resistance to treatment models used in cancer treatment in the last decades, together with the biological phenomena that can

  7. Polymer Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug

    E-Print Network [OSTI]

    Zhang, Liangfang

    Polymer Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug Delivery Santosh Aryal, Che be further es- terified with carboxyl or acid anhydride groups to provide different functionality. Ang et al the synthesis of novel acid-responsive therapeutic nanoparticles (NPs) with sub-100 nm size consisting

  8. Acute Myeloid Leukemia: Nanomedicine drug delivery system could improve chemotherapy

    E-Print Network [OSTI]

    Pfeifer, Holger

    Acute Myeloid Leukemia: Nanomedicine drug delivery system could improve chemotherapy Chemotherapy is still the backbone of today's cancer treatment. This is exemplified by acute myeloid leukemia (AML generation anti-leukemia treatments. The results have been published in the Journal of Advanced Healthcare

  9. anticancer drugs infusion: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    anticancer drugs infusion First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Pharmacokinetic Scaling of...

  10. Nearly all current drugs for osteoporosis act by inhibiting the

    E-Print Network [OSTI]

    for the development of osteoporosis in post-menopausal women. Control mice developed an osteopaenia, whereas mice fedNearly all current drugs for osteoporosis act by inhibiting the resorption of bone, and novel or reverse this disease in rodents. Osteoporosis is characterized by decreased bone density and strength

  11. Smart drug discovery leveraging innovative technologies and predictive knowledge

    E-Print Network [OSTI]

    Cai, Long

    the risk of failure. Owing to the integration of key in silico and experimental tools. A positive aspect of this paradigm shift includes faster,strategic decision making with respect to drug targets from the human genome pro- vides opportunities for detailed analysis of structure and function

  12. Metabolic Regulation and Anticancer Drug Resistance in the Yeast

    E-Print Network [OSTI]

    Metabolic Regulation and Anticancer Drug Resistance in the Yeast Saccharomyces cerevisiae Mattias-91-576-8059-4 © 2014 Mattias Carlsson, Uppsala Print: SLU Service/Repro, Uppsala 2014 #12;Metabolic Regulation regulation by the yeast Rph1p protein, a zinc finger transcription factor which also contains a jmjC domain

  13. An Implantable Bio-Micro-system for Drug Monitoring

    E-Print Network [OSTI]

    De Micheli, Giovanni

    An Implantable Bio-Micro-system for Drug Monitoring Sara Ghoreishizadeh, Enver G. Kilinc, Camilla of the implantable monitoring system for long- term duration has many challenges. First, a multi-target biosen- sor coil; (ii) A power manage- ment IC dealing with the energy source of the implantable microsystem

  14. (c) Meade & Roach, LLP 1 Medicare's Impact on Cardiology Drugs

    E-Print Network [OSTI]

    Weber, David J.

    (c) Meade & Roach, LLP 1 Medicare's Impact on Cardiology Drugs and Devices During Clinical Research Ryan Meade, JD Meade & Roach, LLP July 15, 2008 Baltimore, Maryland University of Maryland School of Medicine #12;(c) Meade & Roach, LLP 2 Overview Theme: Understanding Medicare reimbursement helps

  15. Drug-free Workplace Policy Responsible Administrative Unit: Human Resources

    E-Print Network [OSTI]

    .0 BACKGROUND AND PURPOSE Mines is committed to protecting the health, safety and well-being of all employees significant health, safety and well-being concerns within the Mines working and learning environment. 1 Institutional Alcohol Policy. #12;Drug-free Workplace Policy Responsible Administrative Unit: Human Resources

  16. Stress, Risk Taking, Alcohol/Drugs, and Parents as Partners

    E-Print Network [OSTI]

    Stowell, Michael

    college · Particular Interests Alcohol and other drug abuse Prescription stimulant abuse Marijuana) developmental stage · Need to take risks in order to grow · Frontal part of brain not fully developed · Thinking is inevitable and represents a great learning opportunity Hard to truly grow without setbacks

  17. Drug release from hydrazone-containing peptide amphiphiles

    SciTech Connect (OSTI)

    Matson, John B.; Stupp, Samuel I. (NWU)

    2012-03-15T23:59:59.000Z

    Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine E-amine allowed for precise placement of a hydrazide in a peptide sequence.

  18. Structural Genomics and Drug Discovery for Infectious Diseases

    SciTech Connect (OSTI)

    Anderson, W.F.

    2010-09-03T23:59:59.000Z

    The application of structural genomics methods and approaches to proteins from organisms causing infectious diseases is making available the three dimensional structures of many proteins that are potential drug targets and laying the groundwork for structure aided drug discovery efforts. There are a number of structural genomics projects with a focus on pathogens that have been initiated worldwide. The Center for Structural Genomics of Infectious Diseases (CSGID) was recently established to apply state-of-the-art high throughput structural biology technologies to the characterization of proteins from the National Institute for Allergy and Infectious Diseases (NIAID) category A-C pathogens and organisms causing emerging, or re-emerging infectious diseases. The target selection process emphasizes potential biomedical benefits. Selected proteins include known drug targets and their homologs, essential enzymes, virulence factors and vaccine candidates. The Center also provides a structure determination service for the infectious disease scientific community. The ultimate goal is to generate a library of structures that are available to the scientific community and can serve as a starting point for further research and structure aided drug discovery for infectious diseases. To achieve this goal, the CSGID will determine protein crystal structures of 400 proteins and protein-ligand complexes using proven, rapid, highly integrated, and cost-effective methods for such determination, primarily by X-ray crystallography. High throughput crystallographic structure determination is greatly aided by frequent, convenient access to high-performance beamlines at third-generation synchrotron X-ray sources.

  19. Integrating Bioinformatics, Medical Sciences and Drug Discovery M. Madan Babu

    E-Print Network [OSTI]

    Babu, M. Madan

    .com Bioinformatics Bioinformatics, a term coined for the applications of computer science in biology is now emerging., Bioinformatics plays an important role for the integration of broad disciplines of Biology to understandIntegrating Bioinformatics, Medical Sciences and Drug Discovery M. Madan Babu Centre

  20. New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis

    E-Print Network [OSTI]

    N. Panja; A. K. Chattopadhyay

    2014-12-05T23:59:59.000Z

    We report results of an experimental study, complemented by detailed statistical analysis of the experimental data, on the development of a more effective control method of drug delivery using a pH sensitive acrylic polymer. New copolymers based on acrylic acid and fatty acid are constructed from dodecyl castor oil and a tercopolymer based on methyl methacrylate, acrylic acid and acryl amide were prepared using this new approach. Water swelling characteristics of fatty acid, acrylic acid copolymer and tercopolymer respectively in acid and alkali solutions have been studied by a step-change method. The antibiotic drug cephalosporin and paracetamol have also been incorporated into the polymer blend through dissolution with the release of the antibiotic drug being evaluated in bacterial stain media and buffer solution. Our results show that the rate of release of paracetamol getss affected by the pH factor and also by the nature of polymer blend. Our experimental data have later been statistically analyzed to quantify the precise nature of polymer decay rates on the pH density of the relevant polymer solvents. The time evolution of the polymer decay rates indicate a marked transition from a linear to a strictly non-linear regime depending on the whether the chosen sample is a general copolymer (linear) or a tercopolymer (non-linear). Non-linear data extrapolation techniques have been used to make probabilistic predictions about the variation in weight percentages of retained polymers at all future times, thereby quantifying the degree of efficacy of the new method of drug delivery.

  1. Fundamental chromatographic equations designed for columns packed with very fine particles and operated at very high pressures applications to the prediction of elution times and the column efficiencies

    SciTech Connect (OSTI)

    Gritti, Fabrice [University of Tennessee, Knoxville (UTK); Guiochon, Georges A [ORNL

    2008-01-01T23:59:59.000Z

    The wall temperatures of three Acquity-BEH-C{sub 18}columns (2.1 mm x 50, 100, and 150 mm) and the temperature of the incoming eluent were maintained constant at 289 K, using a circulating water heat exchanger. The retention times and the band broadening of naphtho[2,3-a]pyrene were measured for each column as a function of the flow rate applied. Pure acetonitrile was used as the eluent. The flow rate dependence of neither elution volumes nor bandwidths can be accounted for by classical models of retention and HETP, respectively, since these models assume columns to be isothermal. Because the heat generated by friction of the eluent against the column bed increases with increasing flow rate, the column bed cannot remain isothermal at high flow rates. This heat is evacuated radially and/or longitudinally by convection, conduction, and radiation. Radial and axial temperature gradients are formed, which are maximum and minimum, respectively, when the temperature of the column wall is kept uniform and constant. The retention times that we measured match well with the values predicted based on the temperature distribution along and across the column, which we calculated and on the temperature dependence of the retention for the same column operated isothermally (i.e., at very low flow rate). The rate of band spreading varies along non-isothermal columns, so the HETP can only be defined locally. It is a function of the axial coordinate. A new contribution is needed to account for the radial thermal heterogeneity of the column, hence the radial distribution of the flow velocities, which warps the elution band. A new model, based on the general dispersion theory of Aris, allows a successful prediction of the unusually large bandwidths observed with columns packed with fine particles, operated at high flow rates, hence high inlet pressures.

  2. Utility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism

    SciTech Connect (OSTI)

    Blatherwick, Eleanor Q. [University of Warwick, UK; Van Berkel, Gary J [ORNL; Pickup, Kathryn [AstraZeneca R& D Sweden; Johansson, Maria K. [AstraZeneca R& D Sweden; Beaudoin, Marie-Eve [AstraZeneca, USA; Cole, Roderic [ORNL; Day, Jennifer M. [AstraZeneca R& D, UK; Iverson, Suzanne [AstraZeneca R& D Sweden; Wilson, Ian D. [AstraZeneca R& D, UK; Scrivens, James H. [University of Warwick, UK; Weston, Daniel J. [AstraZeneca R& D, UK

    2011-01-01T23:59:59.000Z

    1. Tissue distribution studies of drug molecules play an essential role in the pharmaceutical industry and are commonly undertaken using quantitative whole body autoradiography (QWBA) methods. 2. The growing need for complementary methods to address some scientific gaps around radiography methods has led to increased use of mass spectrometric imaging (MSI) technology over the last 5 to 10 years. More recently, the development of novel mass spectrometric techniques for ambient surface sampling has redefined what can be regarded as fit-for-purpose for MSI in a drug metabolism and disposition arena. 3. Together with a review of these novel alternatives, this paper details the use of two liquid microjunction (LMJ)- based mass spectrometric surface sampling technologies. These approaches are used to provide qualitative determination of parent drug in rat liver tissue slices using liquid extraction surface analysis (LESA) and to assess the performance of a LMJ surface sampling probe (LMJ-SSP) interface for quantitative assessment of parent drug in brain, liver and muscle tissue slices. 4. An assessment of the utility of these spatially-resolved sampling methods is given, showing interdependence between mass spectrometric and QWBA methods, in particular there emerges a reason to question typical MSI workflows for drug metabolism; suggesting the expedient use of profile or region analysis may be more appropriate, rather than generating time-intensive molecular images of the entire tissue section.

  3. REVIEWS Drug Discovery Today Volume 12, Numbers 1/2 January 2007 Drug-target identification in Drosophila

    E-Print Network [OSTI]

    Perrimon, Norbert

    the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery studies over the years has relied on the ease of growing this organism and the powerful genetic tools such as the insulin, epidermal growth factor, transforming growth factor b, Wnt, Hedgehog, JAK/STAT and Notch pathways

  4. Lightweight Time Modeling in Timed Creol

    E-Print Network [OSTI]

    Bjørk, Joakim; Owe, Olaf; Schlatte, Rudolf; 10.4204/EPTCS.36.4

    2010-01-01T23:59:59.000Z

    Creol is an object-oriented modeling language in which inherently concurrent objects exchange asynchronous method calls. The operational semantics of Creol is written in an actor-based style, formulated in rewriting logic. The operational semantics yields a language interpreter in the Maude system, which can be used to analyze models. Recently, Creol has been applied to the modeling of systems with radio communication, such as sensor systems. With radio communication, messages expire and, if sent simultaneously, they may collide in the air. In order to capture these and other properties of distributed systems, we extended Creol's operational semantics with a notion of time. We exploit the framework of a language interpreter to use a lightweight notion of time, in contrast to that needed for a general purpose specification language. This paper presents a timed extension of Creol, including the semantics and the implementation strategy, and discusses its properties using an extended example. The approach can be...

  5. Intracellular Distribution-based Anticancer Drug Targeting: Exploiting a Lysosomal Acidification Defect Associated with Cancer Cells

    E-Print Network [OSTI]

    Ndolo, Rosemary A.; Jacobs, Damon T.; Forrest, M. Laird; Krise, Jeffrey P.

    2010-09-09T23:59:59.000Z

    previously described a concept for a novel drug delivery platform that relies on the propensity of drugs with optimal physicochemical properties to distribute differently in normal versus cancer cells due to differences in intracellular pH gradients...

  6. Medical data mining : improving information accessibility using online patient drug reviews

    E-Print Network [OSTI]

    Li, Yueyang Alice

    2011-01-01T23:59:59.000Z

    We address the problem of information accessibility for patients concerned about, pharmaceutical drug side effects and experiences. We create a new corpus of online patient-provided drug reviews and present our initial ...

  7. Changes in the characteristics of approved New Drug Applications for antihypertensives

    E-Print Network [OSTI]

    MacNeil, John Simon Howe

    2007-01-01T23:59:59.000Z

    In this thesis, the control of hypertension provides the backdrop for my effort to investigate how clinical trial design has evolved for antihypertensive drug submissions reviewed and approved by the Food and Drug ...

  8. Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON

    E-Print Network [OSTI]

    Fernandez, Eduardo

    Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON Dec. 20, 2012-- The Imagery of pornography: like war porn, torture porn or the standard naked-people porn, drug porn offers up a taste

  9. DEVELOPMENTAL REGULATION OF THE DRUG-PROCESSING GENOME IN MOUSE LIVER

    E-Print Network [OSTI]

    Cui, Yue

    2010-07-29T23:59:59.000Z

    Despite the recent progress in understanding the expression patterns and regulatory mechanisms of drug-processing genes, namely phase-I and -II drug metabolizing enzymes and transporters in adults, very little is known of ...

  10. Reforming pharmaceutical regulation: a case study of generic drugs in Brazil 

    E-Print Network [OSTI]

    Fonseca, Elize Massard da

    2011-12-09T23:59:59.000Z

    Brazil is renowned worldwide for its remarkable reforms in pharmaceutical regulation, which have enhanced access to essential medicines while lowering drug costs. As part of these reforms, the Generic Drug Act was introduced in 1999. This policy...

  11. Reforming pharmaceutical regulation: a case study of generic drugs in Brazil 

    E-Print Network [OSTI]

    Fonseca, Elize Massard

    2012-06-29T23:59:59.000Z

    Brazil is renowned worldwide for its remarkable reforms in pharmaceutical regulation, which have enhanced access to essential medicines while lowering drug costs. As part of these reforms, the Generic Drug Act was ...

  12. Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport

    E-Print Network [OSTI]

    Tang, Hua, 1972-

    2002-01-01T23:59:59.000Z

    Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

  13. FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data Taken at ALS FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data...

  14. Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Colon Cancer 

    E-Print Network [OSTI]

    Pathi, Satya

    2012-10-19T23:59:59.000Z

    Non-steroidal anti-inflammatory drugs (NSAIDs) and their NO derivatives (NO-NSAIDs), and synthetic analogs are highly effective as anticancer agents that exhibit relatively low toxicity compared to most clinically used drugs. However, the mechanisms...

  15. The Major Role of Clinicians in the Discovery of Off-Label Drug Therapies

    E-Print Network [OSTI]

    DeMonaco, Harold J.

    2005-09-23T23:59:59.000Z

    Objective: To determine, through a review of the medical literature and author contact, the role of clinicians in the discovery of off label use of Food and Drug Administration approved prescription drugs.

  16. Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats

    SciTech Connect (OSTI)

    Yamazaki, Makoto; Miyake, Manami; Sato, Hiroko; Masutomi, Naoya; Tsutsui, Naohisa [Mitsubishi Tanabe Pharma Corporation, Kisarazu, Chiba 292-0818 (Japan); Adam, Klaus-Peter; Alexander, Danny C.; Lawton, Kay A.; Milburn, Michael V.; Ryals, John A.; Wulff, Jacob E. [Metabolon Inc., 617 Davis Drive, Suite 400, Durham, NC 27713 (United States); Guo, Lining, E-mail: lguo@metabolon.com [Metabolon Inc., 617 Davis Drive, Suite 400, Durham, NC 27713 (United States)

    2013-04-01T23:59:59.000Z

    Drug-induced liver injury (DILI) is a significant consideration for drug development. Current preclinical DILI assessment relying on histopathology and clinical chemistry has limitations in sensitivity and discordance with human. To gain insights on DILI pathogenesis and identify potential biomarkers for improved DILI detection, we performed untargeted metabolomic analyses on rats treated with thirteen known hepatotoxins causing various types of DILI: necrosis (acetaminophen, bendazac, cyclosporine A, carbon tetrachloride, ethionine), cholestasis (methapyrilene and naphthylisothiocyanate), steatosis (tetracycline and ticlopidine), and idiosyncratic (carbamazepine, chlorzoxasone, flutamide, and nimesulide) at two doses and two time points. Statistical analysis and pathway mapping of the nearly 1900 metabolites profiled in the plasma, urine, and liver revealed diverse time and dose dependent metabolic cascades leading to DILI by the hepatotoxins. The most consistent change induced by the hepatotoxins, detectable even at the early time point/low dose, was the significant elevations of a panel of bile acids in the plasma and urine, suggesting that DILI impaired hepatic bile acid uptake from the circulation. Furthermore, bile acid amidation in the hepatocytes was altered depending on the severity of the hepatotoxin-induced oxidative stress. The alteration of the bile acids was most evident by the necrosis and cholestasis hepatotoxins, with more subtle effects by the steatosis and idiosyncratic hepatotoxins. Taking together, our data suggest that the perturbation of bile acid homeostasis is an early event of DILI. Upon further validation, selected bile acids in the circulation could be potentially used as sensitive and early DILI preclinical biomarkers. - Highlights: ? We used metabolomics to gain insights on drug induced liver injury (DILI) in rats. ? We profiled rats treated with thirteen hepatotoxins at two doses and two time points. ? The toxins decreased the liver's ability to uptake bile acid from the circulation. ? Oxidative stress induced by the toxins altered bile acid biosynthesis in the liver. ? Selected bile acids in the plasma and urine could be sensitive DILI biomarkers.

  17. Noncommutative Two Time Physics

    E-Print Network [OSTI]

    W. Chagas-Filho

    2006-05-10T23:59:59.000Z

    We present a classical formalism describing two-time physics with Abelian canonical gauge field backgrounds. The formalism can be used as a starting point for the construction of an interacting quantized two-time physics theory in a noncommutative soace-time.

  18. Access to Sterile Syringes through San Francisco Pharmacies and the Association with HIV Risk Behavior among Injection Drug Users

    E-Print Network [OSTI]

    Riley, Elise D.; Kral, Alex H.; Stopka, Thomas J.; Garfein, Richard S.; Reuckhaus, Paul; Bluthenthal, Ricky N.

    2010-01-01T23:59:59.000Z

    packets to increase injection drug users’ access to sterileBehavior among Injection Drug Users Elise D. Riley, Alex H.syringes among injection drug users (IDUs) and estimated

  19. Expert Opin Drug Metab Toxicol . Author manuscript The influence of pharmacogenetics and cofactors on clinical outcomes in

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Expert Opin Drug Metab Toxicol . Author manuscript Page /1 12 The influence of pharmacogenetics Abstract Introduction Immunosuppressive drugs have a narrow therapeutic range ; Cytochrome P-450 CYP3A ; genetics ; Dose-Response Relationship, Drug ; Enzyme Inhibitors ; pharmacokinetics

  20. A Juarez drug lord saved my life. Confessions of an accidental narco

    E-Print Network [OSTI]

    Cruz Rosas, Monica

    2013-01-01T23:59:59.000Z

    Organizations: Sinaloa Cartel West Texas High Intensity Drugarchive/ndic/dmas/West_Texas_DMA-2011(U).pdf Drug

  1. E-Print Network 3.0 - antiretroviral drug costs Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: pediatric antiretroviral drug formulations, lack of personnel with health care expertise in treatment... formulations and simplified ARV regimens optimized...

  2. ESPC Success Story- Food and Drug Administration (FDA) White Oak Campus

    Broader source: Energy.gov [DOE]

    FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus.

  3. Results of 1999 Spectral Gamma-Ray and Neutron Moisture Monitoring of Boreholes at Specific Retention Facilities in the 200 East Area, Hanford Site

    SciTech Connect (OSTI)

    DG Horton; RR Randall

    2000-01-18T23:59:59.000Z

    Twenty-eight wells and boreholes in the 200 East Are% Hanford Site, Washington were monitored in 1999. The monitored facilities were past-practice liquid waste disposal facilities and consisted of six cribs and nineteen ''specific retention'' cribs and trenches. Monitoring consisted of spectral gamma-ray and neutron moisture logging. All data are included in Appendix B. The isotopes {sup 137}Cs, {sup 60}Co, {sup 235}U, {sup 238}U, and {sup 154}Eu were identified on spectral gamma logs from boreholes monitoring the PUREX specific retention facilities; the isotopes {sup 137}Cs, {sup 60}Co, {sup 125}Sb, and {sup 154}Eu were identified on the logs from boreholes at the BC Controlled Area cribs and trenches; and {sup 137}Cs, {sup 60}Co, and {sup 125}Sb were, identified on the logs from boreholes at the BX specific retention trenches. Three boreholes in the BC Controlled Area and one at the BX trenches had previous spectral gamma logs available for comparison with 1999 logs. Two of those logs showed that changes in the subsurface distribution of {sup 137}CS and/or {sup 60}Co had occurred since 1992. Although the changes are not great, they do point to continued movement of contaminants in the vadose zone. The logs obtained in 1999 create a larger baseline for comparison with future logs. Numerous historical gross gamma logs exist from most of the boreholes logged. Qualitative comparison of those logs with the 1999 logs show many substantial changes, most of which reflect the decay of deeper short-lived isotopes, such as {sup 106}Ru and {sup 125}Sb, and the much slower decay of shallower and longer-lived isotopes such as {sup 137}Cs. The radionuclides {sup 137}Cs and {sup 60}Co have moved in two boreholes since 1992. Given the amount of movement and the half-lives of the isotopes, it is expected that they will decay to insignificant amounts before reaching groundwater. However, gamma ray logging cannot detect many of the contaminants of interest such as {sup 99}Tc, NO{sub 3}, or {sup 129}I, all of which can be highly mobile in the vadose zone and, for the radionuclides, have long half-lives.

  4. Quantum Operation Time Reversal

    SciTech Connect (OSTI)

    Crooks, Gavin E.

    2008-03-25T23:59:59.000Z

    The dynamics of an open quantum system can be described by a quantum operation: A linear, complete positive map of operators. Here, I exhibit a compact expression for the time reversal of a quantum operation, which is closely analogous to the time reversal of a classical Markov transition matrix. Since open quantum dynamics are stochastic, and not, in general, deterministic, the time reversal is not, in general, an inversion of the dynamics. Rather, the system relaxes toward equilibrium in both the forward and reverse time directions. The probability of a quantum trajectory and the conjugate, time reversed trajectory are related by the heat exchanged with the environment.

  5. CABM Symposium Applications of NMR to structure-based drug design in structural

    E-Print Network [OSTI]

    Powers, Robert

    CABM Symposium Applications of NMR to structure-based drug design in structural genomics Robert, structure-based drug design, structural genomics Abstract Structural genomics is poised to have a tremendous design in the era of structural genomics. Introduction Structure-based drug design has established itself

  6. Modulation of Drug Transport Properties by Multicomponent Diffusion in Surfactant Aqueous Solutions

    E-Print Network [OSTI]

    Annunziata, Onofrio

    Modulation of Drug Transport Properties by Multicomponent Diffusion in Surfactant Aqueous Solutions ReceiVed July 1, 2008 Diffusion coefficients of drug compounds are crucial parameters used for modeling diffusion. A multicomponent diffusion study on drug-surfactant-water ternary mixtures is reported here

  7. Prescription Drug Reimbursement Form See the back for instructions. Complete all information.

    E-Print Network [OSTI]

    Subramanian, Venkat

    Prescription Drug Reimbursement Form See the back for instructions. Complete all information, and that I (or the patient, if not myself) am eligible for prescription drug benefits. I also certify receipts on the back. Member/Subscriber Information See your prescription drug ID card. C1001 9-12 #12;*C

  8. A Cellular Automata Model of the Spread of HIV in a Community of Injection Drug Users

    E-Print Network [OSTI]

    A Cellular Automata Model of the Spread of HIV in a Community of Injection Drug Users Vahid (CSMG), The IRMACS Centre Simon Fraser University Background Intravenous drug users (IDU) sharing needles for injecting illicit drugs are highly vulnerable to HIV infection because transmission

  9. CECM Day 2009 IRMACS Expanding HAART to Control the Spread of HIV Among Injection Drug Users

    E-Print Network [OSTI]

    CECM Day 2009 ­ IRMACS Expanding HAART to Control the Spread of HIV Among Injection Drug Users showed, using a risk behaviour-driven, individual-based (cellular automaton) model of injection drug is likely to be unrealistic for many drug treatment programs, where support is provided that may reduce risk

  10. Drug-FreePolicy University of Kentucky 2012-2013 Undergraduate Bulletin 304

    E-Print Network [OSTI]

    MacAdam, Keith

    Drug-FreePolicy University of Kentucky 2012-2013 Undergraduate Bulletin 304 Policy Statement as a Drug-Free Institution TheUniversityofKentuckyiscommittedtoprovidingahealthyandsafe environment for its, dispensation, distribu- tion or manufacture of alcohol or illicit drugs. Conduct which is violative

  11. Evolution of Drug-resistant Viral Populations during Interruption of Antiretroviral Therapy

    E-Print Network [OSTI]

    Ahlers, Guenter

    1 Evolution of Drug-resistant Viral Populations during Interruption of Antiretroviral Therapy Running title: Evolution and fitness of drug-resistant viruses Dongning Wang1 , Charles B. Hicks2 , Neela antiretroviral treatment (ART) interruption allows determination of the evolution of3 drug-resistant viruses

  12. Drug-FreePolicy University of Kentucky 2013-2014 Undergraduate Bulletin 318

    E-Print Network [OSTI]

    MacAdam, Keith

    Drug-FreePolicy University of Kentucky 2013-2014 Undergraduate Bulletin 318 Policy Statement as a Drug-Free Institution TheUniversityofKentuckyiscommittedtoprovidingahealthyandsafe environment for its, dispensation, distribu- tion or manufacture of alcohol or illicit drugs. Conduct which is violative

  13. MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design

    E-Print Network [OSTI]

    Powers, Robert

    MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design by Coupling to bind a target protein while obtaining structure-related information as part of a struc- ture-based drug for drug discovery is the utilization of a biological assay to screen a large library of compounds (>100

  14. A Drug Administration Decision Support System Wenqi You, Alena Simalatsar, Nicolas Widmer and Giovanni De Micheli

    E-Print Network [OSTI]

    De Micheli, Giovanni

    A Drug Administration Decision Support System Wenqi You, Alena Simalatsar, Nicolas Widmer, Switzerland. Email: nicolas.widmer@chuv.ch Abstract--Drug delivery is one of the most common clinical routines-invasive and accurate way. This paper proposes a Drug Administration Decision Support System (DADSS) to help clinicians

  15. Tobacco, alcohol, cannabis and other illegal drug use among young adults: the socioeconomic context.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Tobacco, alcohol, cannabis and other illegal drug use among young adults: the socioeconomic.drugalcdep.2011.09.002 #12;2 Tobacco, alcohol, cannabis and other illegal drug use among young adults (CAST), other illegal drug use. Socioeconomic position was defined by educational attainment

  16. RESEARCH ARTICLE Open Access Treatment for illegal drug use disorders: the role

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    RESEARCH ARTICLE Open Access Treatment for illegal drug use disorders: the role of comorbid mood for illegal drug use disorders. Methods: Data came from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, 2001­2002 and 2004­2005, n = 34,653). Lifetime DSM-IV illegal drug use

  17. The encapsulation of hydrophobic drugs in Pluronic F127 micelles: the effects of drug hydrophobicity, solution temperature and pH

    E-Print Network [OSTI]

    Rajib Basak; Ranjini Bandyopadhyay

    2014-06-27T23:59:59.000Z

    Three drugs, Ibuprofen, Aspirin and Erythromycin, are encapsulated in spherical Pluronic F127 micelles. The shapes and the size distributions of the micelles in dilute, aqueous solutions, with and without drugs, are ascertained using cryo- Scanning Electron Microscopy and Dynamic Light Scattering (DLS) experiments, respectively. Uptake of drugs above a threshold concentration is seen to reduce the critical micellization temperature of the solution. The mean hydrodynamic radii and polydispersities of the micelles are found to increase with decrease in temperature and in the presence of drug molecules. The hydration of the micellar core at lower temperatures is verified using fluorescence measurements. Increasing solution pH leads to the ionization of the drugs incorporated in the micellar cores. This causes rupture of the micelles and release of the drugs into the solution at the highest solution pH value of 11.36 investigated here and is studied using DLS and fluorescence spectrocopy.

  18. Drug repositioning and indication discovery using description logics

    E-Print Network [OSTI]

    Croset, Samuel

    2014-10-07T23:59:59.000Z

    behind the repurposing. Understanding the logic backing the 21 findings is paramount in order to build successful predictive methods later on. 1.2.1 Sildenafil: repositioning from clinical side-effects The National Health Service (NHS) defines angina as a... breast cancer preventive properties. This drug is an example of smart and continuous development, expanding from one indication to another. The fundamental reasons behind the repositioning are grounded on early-stage experimental evidence and not due to a...

  19. Feeling molecular forces: tactile feedback to enhance drug design

    E-Print Network [OSTI]

    Williams, Jocylin Amber

    2013-02-22T23:59:59.000Z

    Programs 8 Academic Scholarships Texas A8 M University In partial fulfillment of the requirements of the UNIVERSITY UNDERGRADUATE RESEARCH FELLOWS Approved as to style and content by: Edgar F. Meyer' (Fellows-Co-Advisor) Edward A. Funkhouser... Texas A&M University Fellows Advisor: Dr. Edgar F. Meyer Department of Biochemistry and Biophysics Molecular modeling is a vital component for structure-based drug design. Currently implemented technology combines data and graphics to give the user...

  20. Towards engineering hormone-binding globulins as drug delivery agents

    E-Print Network [OSTI]

    Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

    2014-11-26T23:59:59.000Z

    in optical thickness of the sensor tip. Cortisol was immobilised on the biosensor tip surface by forming an adduct of hydrocortisone 21-hemisuccinate and a pentylamine-biotin linker through an amide bond, then allowing the biotin moiety on this cortisol... adduct to bind to the streptavidin-conjugated biosensor tip. The cortisol- Towards Engineering Hormone-Binding Globulins as Drug Delivery Agents PLOS ONE | DOI:10.1371/journal.pone.0113402 November 26, 2014 4 / 21 conjugated sensors were immersed...