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Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Unsupervised parameter optimization for automated retention time alignment of severely shifted gas chromatographic data using the piecework alignment algorithm.  

Science Conference Proceedings (OSTI)

First, simulated chromatographic separations with declining retention time precision were used to study the performance of the piecewise retention time alignment algorithm and to demonstrate an unsupervised parameter optimization method. The average correlation coefficient between the first chromatogram and every other chromatogram in the data set was used to optimize the alignment parameters. This correlation method does not require a training set, so it is unsupervised and automated. This frees the user from needing to provide class information and makes the alignment algorithm more generally applicable to classifying completely unknown data sets. For a data set of simulated chromatograms where the average chromatographic peak was shifted past two neighboring peaks between runs, the average correlation coefficient of the raw data was 0.46 ± 0.25. After automated, optimized piecewise alignment, the average correlation coefficient was 0.93 ± 0.02. Additionally, a relative shift metric and principal component analysis (PCA) were used to independently quantify and categorize the alignment performance, respectively. The relative shift metric was defined as four times the standard deviation of a given peak’s retention time in all of the chromatograms, divided by the peak-width-at-base. The raw simulated data sets that were studied contained peaks with average relative shifts ranging between 0.3 and 3.0. Second, a “real” data set of gasoline separations was gathered using three different GC methods to induce severe retention time shifting. In these gasoline separations, retention time precision improved ~8 fold following alignment. Finally, piecewise alignment and the unsupervised correlation optimization method were applied to severely shifted GC separations of reformate distillation fractions. The effect of piecewise alignment on peak heights and peak areas is also reported. Piecewise alignment either did not change the peak height, or caused it to slightly decrease. The average relative difference in peak height after piecewise alignment was –0.20%. Piecewise alignment caused the peak areas to either stay the same, slightly increase, or slightly decrease. The average absolute relative difference in area after piecewise alignment was 0.15%.

Pierce, Karisa M.; Wright, Bob W.; Synovec, Robert E.

2007-02-02T23:59:59.000Z

2

White Oak Creek Embayment time-critical CERCLA removal action sediment-retention structure. Environmental Restoration Program  

SciTech Connect

Over a 20-month period between September 1990 and April 1992, the Department of Energy (DOE), acting through Martin Marietta Energy Systems, Inc., managing contractor for the DOE Oak Ridge Field Office (DOE-OR), conducted a DOE-lead and DOE-funded time-critical removal action at the White Oak Creek Embayment (WOCE), pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). The time-critical removal action specifically consisted of the design and construction of a sediment-retention structure across the mouth of WOCE to prevent off-site migration of sediments contaminated by cesium ({sup 137}Cs) into the Clinch River. Construction of a sediment-retention structure was completed in mid-April 1992. The purpose of this report is to meet the substantive requirements of 40 CFR 300.165 describing ``a complete report on the removal operation and the actions taken.`` This section of the NCP specifically addresses on-scene coordinator reports for the Environmental Protection Agency (EPA) Superfund-lead actions and includes several elements that are not applicable to this DOE-lead action. Only those sections that are pertinent and applicable are addressed in this final report.

1992-09-01T23:59:59.000Z

3

Gas Chromatographic Retention Data  

Science Conference Proceedings (OSTI)

... Lee retention indices are determined by analogy with Kovats indices for the following reference compounds: benzene, naphthalene, phenanthrene ...

2013-07-15T23:59:59.000Z

4

Technetium Retention During LAW Vitrification  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

retention * More reducing bubbler gases were not effective * For a given glass production rate increase, increased bubbling results in better retention than increased temperature *...

5

Hydrogen Retention in Tetraphenylborate Slurries  

DOE Green Energy (OSTI)

Researchers measured the production and retention of gases in potassium tetraphenylborate (KTPB) slurries due to radiolysis.

Peterson, R.A.

1998-10-21T23:59:59.000Z

6

Work Force Retention Work Group Charter  

Energy.gov (U.S. Department of Energy (DOE))

The Work force Retention Work Group is established to support the Department’s critical focus on maintaining a high-performing work force at a time when a significant number of the workers needed to support DOE’s national security mission are reaching retirement age.

7

Workforce Retention | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Services » Outreach & Collaboration » Focus Groups » Workforce Services » Outreach & Collaboration » Focus Groups » Workforce Retention Workforce Retention The HSS Workforce Retention Work Group was established to collaboratively address the needs of the Department to maintain a skilled work force in the face of anticipated retirements and to address the specific health and safety concerns of that work force that could impede retention. Objectives: Better understand relationship between skilled workforce retention; health, safety and productivity; and especially preventive health care. Inform and support improvement and/or development of wellness, fitness, and prevention programs through data collections and analyses. Promote the implementation of preventive health services designed to assure retention of the contractor work force.

8

Drug Detection Study  

Office of Scientific and Technical Information (OSTI)

ORISE-07-NSEM-0544 ORISE-07-NSEM-0544 U.S. Department of Energy Office of Health, Safety and Security Office of Security Policy Drug Retention Times Center for Human Reliability Studies Oak Ridge Institute for Science and Education Operated by Oak Ridge Associated Universities For the U.S. Department of Energy Oak Ridge Associated Universities (ORAU) is a university consortium leveraging the scientific strength of major research institutions to advance science and education by partnering with national laboratories, government agencies, and private industry. ORAU manages the Oak Ridge Institute for Science and Education for the U.S. Department of Energy. The Oak Ridge Institute for Science and Education (ORISE) is a U.S. Department of Energy institute focusing on

9

Technetium Retention During LAW Vitrification  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Technetium Retention During Technetium Retention During LAW Vitrification Ian L. Pegg Vitreous State Laboratory The Catholic University of America Washington, DC November 18, 2010 Overview * Tc in borosilcate glass structure * Re as a surrogate for Tc * Summary of previous data on Tc incorporation into LAW glass * Summary of results from ongoing test program * Single-pass retention vs. retention with recycle * Tc volatilization during container filling Tc in LAW Glass Structure * Tc is present as Tc 7+ and Tc 4+ * Tc 7+ is dominant in more oxidized glasses and Tc 4+ is dominant in reduced glasses * Strongly reducing conditions produce Tc 0 * The structure and local environment of Tc in WTP LAW glasses has been investigated by: * Synchrotron X-Ray Absorption Spectroscopy * Lukens, McKeown, Buechele, Muller, Shuh, and Pegg, Chem. Mater., 19, 559 (2007)

10

Records retention in relational database systems  

Science Conference Proceedings (OSTI)

The recent introduction of several pieces of legislation mandating minimum and maximum retention periods for corporate records has prompted the Enterprise Content Management (ECM) community to develop various records retention solutions. Records retention ... Keywords: business records, legal compliance, privacy, records retention, relational systems

Ahmed A. Ataullah; Ashraf Aboulnaga; Frank Wm. Tompa

2008-10-01T23:59:59.000Z

11

July 2012, Work Force Retention Work Group Status Overview  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Work Force Retention Work Group Status Overview Work Force Retention Work Group Status Overview Accomplishments: 1. Progress on the completion of the 10 CFR 1046 modifications to address barriers to workforce retention. Written response to public comment is being drafted by HS-51. 2. Pro-Force (PF) union representative, Randy Lawson, identified this accomplishment as the single most significant step toward PF workforce retention in over 20 years. 3. Draft re-charter of PF Career Options Committee (PFCOC) to establish a PF Working Group approved by GC-63 and GC NNSA. Near Term Goals and Activities: 1. Publish 1046 as a final rule - anticipated completion no later than September, assuming timely OMB review and approval. 2. Draft PF Working Group charter final review by senior management to be

12

Retention of hydrogen in graphite  

DOE Green Energy (OSTI)

The retention of hydrogen in POCO AXF-5Q graphite has been measured at room temperature as a function of fluence and flux for H/sub 2//sup +/ ions at energies from 250 to 500 eV provided by a glow discharge. More than 2 x 10/sup 18/ H/cm/sup 2/ has been retained, and no indication of saturation has been observed to a fluence of 5 x 10/sup 19/ H/cm/sup 2/. In this experiment, retention was found to increase linearly with fluence for constant flux. A flux dependence was observed; that is, the retention rate was observed to decrease monotonically as the flux increased. A change-over experiment, deuterium to hydrogen, was conducted; the results show that significant change-over occurs (i.e., about 30% change-over for a fluence of 5 x 10/sup 17/ D/cm/sup 2/).

Langley, R.A.

1986-10-01T23:59:59.000Z

13

Mechanisms of gas bubble retention  

Science Conference Proceedings (OSTI)

Retention and episodic release of flammable gases are critical safety concerns regarding double-shell tanks (DSTs) containing waste slurries. Previous investigations have concluded that gas bubbles are retained by the slurry that has settled at the bottom of the DST. However, the mechanisms responsible for the retention of these bubbles are not well understood. In addition, the presence of retained gas bubbles is expected to affect the physical properties of the sludge, but essentially no literature data are available to assess the effect of these bubbles. The rheological behavior of the waste, particularly of the settled sludge, is critical to characterizing the tendency of the waste to retain gas bubbles. The objectives of this study are to elucidate the mechanisms contributing to gas bubble retention and release from sludge such as is in Tank 241-SY-101, understand how the bubbles affect the physical properties of the sludge, develop correlations of these physical properties to include in computer models, and collect experimental data on the physical properties of simulated sludges with bubbles. This report presents a theory and experimental observations of bubble retention in simulated sludge and gives correlations and new data on the effect of gas bubbles on sludge yield strength.

Gauglitz, P.A.; Mahoney, L.A.; Mendoza, D.P.; Miller, M.C.

1994-09-01T23:59:59.000Z

14

BitVault: a highly reliable distributed data retention platform  

Science Conference Proceedings (OSTI)

This paper summarizes our experience designing and implementing BitVault: a content-addressable retention platform for large volumes of reference data -- seldom-changing information that needs to be retained for a long time. BitVault uses "smart bricks" ...

Zheng Zhang; Qiao Lian; Shiding Lin; Wei Chen; Yu Chen; Chao Jin

2007-04-01T23:59:59.000Z

15

Radionuclide Retention in Concrete Wasteforms  

SciTech Connect

Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how wasteform performance is affected by the full range of environmental conditions within the disposal facility; the process of wasteform aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of wasteform aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the wasteforms come in contact with groundwater. Data collected throughout the course of this work will be used to quantify the efficacy of concrete wasteforms, similar to those used in the disposal of LLW and MLLW, for the immobilization of key radionuclides (i.e., uranium, technetium, and iodine). Data collected will also be used to quantify the physical and chemical properties of the concrete affecting radionuclide retention.

Wellman, Dawn M.; Jansik, Danielle P.; Golovich, Elizabeth C.; Cordova, Elsa A.

2012-09-24T23:59:59.000Z

16

DOE Handbook on Recruitment and Retention Incentives  

Energy.gov (U.S. Department of Energy (DOE))

This publication provides sample plans, service agreements, and management worksheets for administering recruitment, relocation, and retention incentives and repayment of student loans.

17

Stationary Phases in Gas Chromatographic Retention Data  

Science Conference Proceedings (OSTI)

... lists below contain names of stationary phases found in the gas chromatography retention ... CP Sil 2; Nonpolar; LM-5; JXR; Vacuum Grease Oil (VM-4) ...

2013-07-15T23:59:59.000Z

18

Radionuclide Retention in Concrete Wasteforms  

Science Conference Proceedings (OSTI)

Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how wasteform performance is affected by the full range of environmental conditions within the disposal facility; the process of wasteform aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of wasteform aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the wasteforms come in contact with groundwater. The information present in the report provides data that (1) measures the effect of concrete wasteform properties likely to influence radionuclide migration; and (2) quantifies the rate of carbonation of concrete materials in a simulated vadose zone repository.

Bovaird, Chase C.; Jansik, Danielle P.; Wellman, Dawn M.; Wood, Marcus I.

2011-09-30T23:59:59.000Z

19

Plasma wall interaction and tritium retention in TFTR  

SciTech Connect

The Tokamak Fusion Test Reactor (TFTR) has been operating safely and routinely with deuterium-tritium fuel for more than two years. In this time, TFTR has produced an impressive number of record breaking results including core fusion power, {approximately} 2 MW/m{sup 3}, comparable to that expected for ITER. Advances in wall conditioning via lithium pellet injection have played an essential role in achieving these results. Deuterium-tritium operation has also provided a special opportunity to address the issues of tritium recycling and retention. Tritium retention over two years of operation was approximately 40%. Recently, the in-torus tritium inventory was reduced by half through a combination of glow discharge cleaning, moist-air soaks, and plasma discharge cleaning. The tritium inventory is not a constraint in continued operations. The authors present recent results from TFTR in the context of plasma wall interactions and deuterium-tritium issues.

Skinner, C.H.; Amarescu, E.; Ascione, G. [and others

1996-08-01T23:59:59.000Z

20

ADDITIVE TESTING FOR IMPROVED SULFUR RETENTION: PRELIMINARY REPORT  

SciTech Connect

The Savannah River National Laboratory is collaborating with Alfred University to evaluate the potential for additives in borosilicate glass to improve sulfur retention. This preliminary report provides further background on the incorporation of sulfur in glass and outlines the experiments that are being performed by the collaborators. A simulated waste glass composition has been selected for the experimental studies. The first phase of experimental work will evaluate the impacts of BaO, PbO, and V{sub 2}O{sub 5} at concentrations of 1.0, 2.0, and 5.0 wt % on sulfate retention in simulated high level waste borosilicate glass. The second phase of experimental work will evaluate the effects of time at the melt temperature on sulfur retention. The resulting samples will be characterized to determine the amount of sulfur remaining as well as to identify the formation of any crystalline phases. The results will be used to guide the future selection of frits and glass forming chemicals in vitrifying Department of Energy wastes containing high sulfur concentrations.

Amoroso, J.; Fox, K.

2011-09-07T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

DOE Handbook on Recruitment and Retention Incentives | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Handbook on Recruitment and Retention Incentives Handbook on Recruitment and Retention Incentives DOE Handbook on Recruitment and Retention Incentives This desk reference contains sample recruitment, relocation, retention, and student loan incentive plans and service agreements for eligible employees; sample worksheets to assist in documenting the justification and approvals for all types of recruitment and retention incentives; information on superior qualification determinations; guidance and sample documents regarding crediting directly-related service for annual leave for new appointments; frequently asked questions regarding relocation expenses; and other relevant documents. This desk reference is intended to supplement information currently available in the following references. DOE Handbook on Recruitment and Retention Incentives

22

Prescription Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Prescription Drugs Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue Cross and Blue Shield of New Mexico (BCBSNM) health plan includes a prescription drug benefit administered by Prime Therapeutics. The cost of the prescription drug plan is included in your medical premiums. Coverage The co-pays for prescription drugs are based on a 3-tier prescription drug benefit. Co-payments are different for formulary or non-formulary, generic, or brand/preferred name. Review the BCBSNM Drug List (pdf) to find out which tier a specific drug falls under. Co-pays Prescription drug co-pays vary from plan to plan. 2013 EPO Summary of Benefits (pdf) 2013 PPO Summary of Benefits (pdf)

23

(WPI-iCeMS) Pure Nano Drugs*  

E-Print Network (OSTI)

(WPI-iCeMS) SN-38 50 nm * Pure Nano Drugs* SN-38 10 HepG2* JST (-STEP Permeation and Retention (EPR)* EPR 20100 nm SN-38 SN-38 * SN-38 * SN-38 20 SN-38 Pure Nano Drugs

Takada, Shoji

24

STUDY OF HELIUM RETENTION IN NANO-CAVITY ...  

Science Conference Proceedings (OSTI)

STUDY OF HELIUM RETENTION IN NANO-CAVITY TUNGSTEN AS A FIRST WALL IN A FUSION CHAMBER USING NEUTRON DEPTH ...

25

The purpose of this Record Retention and Destruction Policy  

Science Conference Proceedings (OSTI)

management systems; and. • recorded audio ... Schedule (Attachment A) that is approved as the maintenance, retention and disposal schedule for official ...

26

Using a shallow linguistic kernel for drug-drug interaction extraction  

Science Conference Proceedings (OSTI)

A drug-drug interaction (DDI) occurs when one drug influences the level or activity of another drug. Information Extraction (IE) techniques can provide health care professionals with an interesting way to reduce time spent reviewing the literature for ... Keywords: Biomedical information extraction, Drug-drug interactions, Machine learning, MetaMap, Patient safety, Shallow linguistic kernel, Unified medical language system

Isabel Segura-Bedmar; Paloma MartíNez; Cesar De Pablo-SáNchez

2011-10-01T23:59:59.000Z

27

Moisture retention properties of a mycorrhizal soil  

E-Print Network (OSTI)

The water relations of arbuscular mycorrhizal plants have been compared often, but virtually nothing is known about the comparative water relations of mycorrhizal and nonmycorrhizal soils. Mycorrhizal symbiosis typically affects soil structure, and soil structure affects water retention properties; therefore, it seems likely that mycorrhizal symbiosis may affect soil water relations. We examined the water retention properties of a Sequatchie fine sandy loam subjected to three treatments: seven months of root growth by (1) nonmycorrhizal Vigna unguiculata given low phosphorus fertilization, (2) nonmycorrhizal Vigna unguiculata given high phosphorus fertilization, (3) Vigna unguiculata colonized by Glomus intraradices and given low phosphorus fertilization. Mycorrhization of soil had a slight but significant effect on the soil moisture characteristic curve. Once soil matric potential (\\11m) began to decline, changes in \\II m per unit change in soil water content were smaller in mycorrhizal than in the two nonmycorrhizal soils. Within the range of about-1 to-5 MPa, the mycorrhizal soil had to dry more than the nonmycorrhizal soils to reach the same \\11m. Soil characteristic curves of non mycorrhizal soils were similar, whether they contained roots of plants fed high or low phosphorus. The mycorrhizal soil had significantly more water stable aggregates and substantially higher extraradical hyphal densities than the nonmycorrhizal soils. Importantly, we were able to factor out the possibly confounding influence of differential root growth among mycorrhizal and nonmycorrhizal

Robert M. Augel; Ann L. W. Stodola; Layme E. Tims; Arnold M. Saxton

2000-01-01T23:59:59.000Z

28

Radionuclide Retention in Concrete Wasteforms - FY13  

SciTech Connect

Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how wasteform performance is affected by the full range of environmental conditions within the disposal facility; the process of wasteform aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of wasteform aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the wasteforms come in contact with groundwater. Data collected throughout the course of this work will be used to quantify the efficacy of concrete wasteforms, similar to those used in the disposal of low-level waste and mixed low-level waste, for the immobilization of key radionuclides (i.e., uranium, technetium, and iodine). Data collected will also be used to quantify the physical and chemical properties of the concrete affecting radionuclide retention.

Snyder, Michelle MV; Golovich, Elizabeth C.; Wellman, Dawn M.; Crum, Jarrod V.; Lapierre, Robert; Dage, Denomy C.; Parker, Kent E.; Cordova, Elsa A.

2013-10-15T23:59:59.000Z

29

Radionuclide Retention in Concrete Waste Forms  

Science Conference Proceedings (OSTI)

Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how waste form performance is affected by the full range of environmental conditions within the disposal facility; the process of waste form aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of waste form aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the waste forms come in contact with groundwater. The information presented in the report provides data that 1) quantify radionuclide retention within concrete waste form materials similar to those used to encapsulate waste in the Low-Level Waste Burial Grounds (LLBG); 2) measure the effect of concrete waste form properties likely to influence radionuclide migration; and 3) quantify the stability of uranium-bearing solid phases of limited solubility in concrete.

Mattigod, Shas V.; Bovaird, Chase C.; Wellman, Dawn M.; Wood, Marcus I.

2010-09-30T23:59:59.000Z

30

Factors Associated with Increasing Teacher Retention in Rural Schools.  

E-Print Network (OSTI)

??This paper seeks to identify school-based factors associated with increasing teacher retention in rural public schools. Though there is a large body of research that… (more)

Rutenberg, David

31

September 2012, Work Force Retention Work Group Status Overview  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Work Force Retention Work Group Status Overview Work Force Retention Work Group Status Overview 2 Subgroups: Pro-Force and Non-Pro-Force Pro-Force Subgroup: Accomplishments: 1. Completion of 10 CFR 1046 [Protective Force Personnel Medical, Physical Readiness, Training, and Access Authorization Standards] as a final rule that includes modification efforts to address barriers to workforce retention. 2. Pro-Force (PF) union representative, Randy Lawson, identified this accomplishment as the single most significant step toward PF workforce retention in over 20 years. 3. Draft re-charter of PF Career Options Committee (PFCOC) to establish a PF Working Group approved by GC-63 and GC NNSA. Near Term Goals and Activities: 1. Publish 1046 as a final rule - publication anticipated this month.

32

The Influence of Land Surface Moisture Retention on Precipitation Statistics  

Science Conference Proceedings (OSTI)

The retention of precipitation water in land surface reservoirs damps higher frequencies of evaporation variability and can thereby influence the feedback of evaporation on precipitation. The extent of this influence is examined in a series of ...

Randal D. Koster; Max J. Suarez

1996-10-01T23:59:59.000Z

33

Bubble retention in synthetic sludge: Testing of alternative gas retention apparatus  

SciTech Connect

Several of the underground storage tanks currently used to store waste at Hanford have been placed on the Flammable Gas Watch List, because the waste is either known or suspected to generate, store, and episodically release flammable gases. The objective of this experimental study is to develop a method to measure gas bubble retention in simulated tank waste and in diluted simulant. The method and apparatus should (1) allow for reasonably rapid experiments, (2) minimize sample disturbance, and (3) provide realistic bubble nucleation and growth. The scope of this experimental study is to build an apparatus for measuring gas retention in simulated waste and to design the apparatus to be compatible with future testing on actual waste. The approach employed for creating bubbles in sludge involves dissolving a soluble gas into the supernatant liquid at an elevated pressure, recirculating the liquid containing the dissolved gas through the sludge, then reducing the pressure to allow bubbles to nucleate and grow. Results have been obtained for ammonia as the soluble gas and SY1-SIM-91A, a chemically representative simulated tank waste. In addition, proof-of-principle experiments were conducted with both ammonia and CO{sub 2} as soluble gases and sludge composed of 90-micron glass beads. Results are described.

Rassat, S.D.; Gauglitz, P.A.

1995-07-01T23:59:59.000Z

34

Mexico Border HIV Drug abuse  

E-Print Network (OSTI)

Ó The Author(s) 2011. This article is published with open access at Springerlink.com Abstract We examined correlates of ever injecting drugs in Mexico among residents of San Diego, California. From 2007 to 2010, injecting drug users (IDUs) in San Diego underwent an interviewer-administered survey. Logistic regression identified correlates of injection drug use in Mexico. Of 302 IDUs, 38 % were Hispanic, 72 % male and median age was 37; 27 % ever injected in Mexico; 43% reported distributive syringe sharing there. Factors independently associated with ever injecting drugs in Mexico included being younger at first injection, injecting heroin, distributive syringe sharing at least half of the time, and transporting drugs over the last 6 months. One-quarter of IDUs reported ever injecting drugs in Mexico, among whom syringe sharing was common, suggesting possible mixing between IDUs in the Mexico-US border region. Prospective studies should monitor trends in cross-border drug use in light of recent Mexican drug policy reforms partially decriminalizing drug possession.

Tyson Volkmann; Sanghyuk S. Shin; Richard S. Garfein; Irina Artamanova; Steffanie A. Strathdee; T. Volkmann; S. S. Shin; R. S. Garfein; R. A. Pollini; K. D. Wagner; I. Artamanova; S. A. Strathdee; T. L. Patterson

2011-01-01T23:59:59.000Z

35

SUBJECT: Guidance on Retention of Facility Representative Technical  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

SUBJECT: Guidance on Retention of Facility Representative Technical SUBJECT: Guidance on Retention of Facility Representative Technical Competence during Reductions in Force, 4/21/1998 SUBJECT: Guidance on Retention of Facility Representative Technical Competence during Reductions in Force, 4/21/1998 The Department's Revised Implementation Plan (IP) for Defense Nuclear Facilities Safety Board Recommendation 93-3 renews the Department's commitment to maintaining the technical capability necessary to safely manage and operate defense nuclear facilities. Retaining highly qualified employees in critical technical skills areas is vital to the maintenance of these technical capabilities. The Department has therefore committed in the revised R? to the development of a model that offices can use to proactively manage and preserve critical technical capabilities. During the

36

Retention of Tracer Gas from Instantaneous Releases of SF6 in an Urban Environment  

SciTech Connect

Data from a series of instantaneous releases of SF6 tracer during the Joint Urban 2003 study in Oklahoma City have been analyzed to determine characteristic retention times for puffs in an urban environment. Results from nine real-time tracer detectors with a time response of 0.5 seconds were used in the analysis. Distances from the source ranged from less than 200 m to over 1 km. For each individual intensive operating period (IOP), the detector locations were adjusted so that, given the expected wind directions during the releases, the detectors would lie generally downwind of the release point. As a result, building characteristics upwind of the detectors varied from one IOP to the next. Animations of the tracer concentrations show clear evidence of channeling along street canyons approximately parallel to the prevailing wind directions, trapping in street canyons perpendicular to the flow, and other complex circulation patterns. Retention times for individual puffs ranged from a few minutes to over 20 minutes, with a strong mode in the distribution around 11 minutes. There was surprisingly little correlation with wind speed or direction. Comparisons with simple puff models are presented.

Doran, J. C.; Allwine, K Jerry; Clawson, Kirk L.; Carter, Roger G.

2006-01-01T23:59:59.000Z

37

Microfabricated injectable drug delivery system  

DOE Patents (OSTI)

A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

2002-01-01T23:59:59.000Z

38

Workforce Retention Accomplishments Presentation - Sustainability Assessment of Workforce Well-Being and Mission Readiness  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Sustainability Assessment of Workforce Sustainability Assessment of Workforce Well-Being and Mission Readiness Jodi M. Jacobson, Ph.D., University of Maryland 2 Illness and Injury Lost Work Time Generational Divide Recruitment & Retention Competition Retirement & Aging Workforce Health & Well-Being Stress Depression & Anxiety Budget Cuts Technology Talent Management Work/Life Balance Safety Accountability Security Leadership Development Workforce Sustainability Chronic Health Conditions Globalization Critical Skills Shortage Job Skill Re-Alignment Job Transitioning Healthcare Costs YOU ARE NOT ALONE! 3 Indirect Costs  "You can"t manage what you can"t measure" (Dr. Ron Goetzel, Director, Institute for Health & Productivity Studies, Cornell University)

39

Efficient audit-based compliance for relational data retention  

Science Conference Proceedings (OSTI)

The Sarbanes-Oxley Act inspired research on long-term high-integrity retention of business records, leveraging the immutability guarantees that WORM storage servers offer for files. In this paper, we present the transaction log on WORM (TLOW) ... Keywords: audit, forensics, regulatory compliance

Ragib Hasan; Marianne Winslett

2011-03-01T23:59:59.000Z

40

Online idea contests: identifying factors for user retention  

Science Conference Proceedings (OSTI)

Current literature about idea contests has emphasized individuals' motives for joining volunteer idea contests. However, explanation of why people stay or leave in the long run is rare. We identify factors that motivate users to participate repeatedly ... Keywords: motivation, multiple idea contests, open innovation, user retention

Stefan Richter, Stefan Perkmann Berger, Giordano Koch, Johann Füller

2013-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Hydrogen retention and release from uranium dioxide  

DOE Green Energy (OSTI)

The ceramic samples (UO/sub 2/) are exposed to high pressure hydrogen gas at a fixed temperature for a time sufficient to achieve equilibrium. After rapid quenching, the hydrogen-saturated sample is transferred to a vacuum-outgassing furnace. The sample is outgassed in a linear temperature ramp and the released hydrogen is detected by an in-situ mass spectrometer. This technique measures the rate of release of hydrogen with a sensitivity level of about 2 ng of hydrogen (as D/sub 2/) per hour. In this study, experiments were conducted on both polycrystalline and single-crystal UO/sub 2/. Experimental variables included temperature (1000 to 1600/sup 0/C) and infusion pressure (5 to 32 atm D/sub 2/), and for the polycrystalline specimen, stoichiometry. Dissolution of H/sub 2/ in both single-crystal and polycrystalline UO/sub 2/ was found to obey Seivert's law. The Sievert's law constant of deuterium in single-crystal UO/sub 2/ was determined to be: 3.0 x 10/sup 7/exp(-235 kJ/RT) ppM atomic/..sqrt..atm and for polycrystalline UO/sub 2/: 5.5 x 10/sup 4/exp(-100 kJ/RT) ppM atomic/..sqrt..atm. The solubility of hydrogen in hypostoichiometric urania was found to be up to three orders of magnitude greater than in stoichiometric UO/sub 2/ depending on the O/U ratios, implying the anion vacancy is the primary solution site in the UO/sub 2/ lattice. The release-rate curves for the single crystal and polycrystalline UO/sub 2/ specimens exhibited multiple peaks, with most of the deuterium released between 600 and 1200/sup 0/C for the polycrystalline samples, and between 700 and 1800/sup 0/C in the single-crystal specimens. This release of hydrogen from UO/sub 2/ could not be adequately modeled as diffusion or diffusion with trapping and resolution. It was determined that release was governed by release from traps in both the polycrystalline and single crystal UO/sub 2/ specimens. 40 refs., 72 figs., 6 tabs.

Sherman, D.F.

1987-08-01T23:59:59.000Z

42

Bugs, Drugs & Smoke  

E-Print Network (OSTI)

burden of drug-resistant TB, including four – China, India,on drug-resistant TB organized by WHO in Beijing, China, inChina, the Democratic Republic of the Congo, Estonia, Ethiopia, Georgia, India, Indonesia, in new drug-

WHO

2012-01-01T23:59:59.000Z

43

Slurry growth and gas retention in synthetic Hanford waste  

DOE Green Energy (OSTI)

This work seeks to establish chemical and physical processes responsible for the generation and retention of gases within waste from a particular high-level waste tank on the Hanford Site, Tank 101-SY, through the use of synthetic wastes on a laboratory scale. The goal of these activities is to support the development of mitigation/remediation strategies for Tank 101-SY. Laboratory studies of aged synthetic waste have shown that gas generation occurs thermally at a significant level at current tank temperatures. Gas compositions include the same gases produced in actual tank waste, primarily N{sub 2}, N{sub 2}O, and H{sub 2}. Gas stoichiometries have been shown to be greatly influenced by several organic and inorganic constituents within the synthetic waste. Retention of gases in the synthetic waste is in the form of bubble attachment to solid particles.

Bryan, S.A.; Pederson, L.R.; Scheele, R.D.

1992-09-01T23:59:59.000Z

44

Slurry growth and gas retention in synthetic Hanford waste  

DOE Green Energy (OSTI)

This work seeks to establish chemical and physical processes responsible for the generation and retention of gases within waste from a particular high-level waste tank on the Hanford Site, Tank 101-SY, through the use of synthetic wastes on a laboratory scale. The goal of these activities is to support the development of mitigation/remediation strategies for Tank 101-SY. Laboratory studies of aged synthetic waste have shown that gas generation occurs thermally at a significant level at current tank temperatures. Gas compositions include the same gases produced in actual tank waste, primarily N[sub 2], N[sub 2]O, and H[sub 2]. Gas stoichiometries have been shown to be greatly influenced by several organic and inorganic constituents within the synthetic waste. Retention of gases in the synthetic waste is in the form of bubble attachment to solid particles.

Bryan, S.A.; Pederson, L.R.; Scheele, R.D.

1992-09-01T23:59:59.000Z

45

Average Soil Water Retention Curves Measured by Neutron Radiography  

SciTech Connect

Water retention curves are essential for understanding the hydrologic behavior of partially-saturated porous media and modeling flow transport processes within the vadose zone. In this paper we report direct measurements of the main drying and wetting branches of the average water retention function obtained using 2-dimensional neutron radiography. Flint sand columns were saturated with water and then drained under quasi-equilibrium conditions using a hanging water column setup. Digital images (2048 x 2048 pixels) of the transmitted flux of neutrons were acquired at each imposed matric potential (~10-15 matric potential values per experiment) at the NCNR BT-2 neutron imaging beam line. Volumetric water contents were calculated on a pixel by pixel basis using Beer-Lambert s law after taking into account beam hardening and geometric corrections. To remove scattering effects at high water contents the volumetric water contents were normalized (to give relative saturations) by dividing the drying and wetting sequences of images by the images obtained at saturation and satiation, respectively. The resulting pixel values were then averaged and combined with information on the imposed basal matric potentials to give average water retention curves. The average relative saturations obtained by neutron radiography showed an approximate one-to-one relationship with the average values measured volumetrically using the hanging water column setup. There were no significant differences (at p < 0.05) between the parameters of the van Genuchten equation fitted to the average neutron radiography data and those estimated from replicated hanging water column data. Our results indicate that neutron imaging is a very effective tool for quantifying the average water retention curve.

Cheng, Chu-Lin [ORNL; Perfect, Edmund [University of Tennessee, Knoxville (UTK); Kang, Misun [ORNL; Voisin, Sophie [ORNL; Bilheux, Hassina Z [ORNL; Horita, Juske [Texas Tech University (TTU); Hussey, Dan [NIST Center for Neutron Research (NCRN), Gaithersburg, MD

2011-01-01T23:59:59.000Z

46

Moisture Retention Curves of Topopah Spring Tuff at Elevated Temperatures  

SciTech Connect

Knowledge of unsaturated flow and transport in porous media is critical for understanding the movement of water and solute through the unsaturated zone. The suction potential of rock determines the imbibition of water and, therefore, the moisture retention in the matrix. That, in turn, affects the relative importance of matrix flow and fracture flow, and their interaction, because greater suction potential moves more water from fractures into the matrix and therefore retards fracture flow. The moisture content as a function of the suction potential is called a moisture retention curve or a characteristic curve. Moisture-retention data are important input for numerical models of water movement in unsaturated porous media. Also important are the effect of sample history on the moisture-retention curves and whether there is significant hysteresis between wetting and drying measurements. The Yucca Mountain Site Characterization Project (YMP) of the U.S. Department of Energy is studying the suitability of the tuffaceous rock at Yucca Mountain, Nevada, for a potential high-level nuclear waste repository. The potential repository horizon will be in the unsaturated zone of the Topopah Spring member (densely welded) of the Paintbrush Tuff unit at Yucca Mountain. This unit is highly fractured. Therefore, transport of water within the near field of the nuclear waste package in the repository is strongly influenced by the suction potential of the repository host rocks at elevated temperatures. In a high-level nuclear waste repository, the rock mass around the waste packages will become dry because of the thermal load of the waste but will then re-wet during the cool-down period as the thermal output of the waste packages declines. Much of this process will occur at temperatures above ambient temperature. The goal of our work is to determine the importance of temperature and the wetting-drying hysteresis on the measured moisture retention curves of the densely welded tuff. For Topopah Spring tuff the suction potential is assumed to be primary due to the matric potential.

Lin, W.; Roberts, J.; Carlberg, E.; Ruddle, D.; Pletcher, R.

2001-11-30T23:59:59.000Z

47

A Particle-Water Based Model for Water Retention Hysteresis  

E-Print Network (OSTI)

A particle-water discrete element-based approach to describe water movement in partially saturated granular media is presented and tested. Water potential is governed by both capillary bridges, dominant at low saturations, and pressure of entrapped air, dominant at high saturations. The approach captures the hysteresis of water retention during wetting and drainage by introducing local evolution of liquid-solid contact angles at the level of pores and grains. Next, extensive comparisons against experimental data are presented. While this is made without involving any fitting parameters, the method demonstrates relative high success by achieving a correlation coefficient of at least 82%, and mostly above 90%.

Yixiang Gan; Federico Maggi; Giuseppe Buscarnera; Itai Einav

2013-07-20T23:59:59.000Z

48

Whole body retention and tissue distribution of (/sup 203/Hg)methylmercury in adult cats  

SciTech Connect

To assess the whole body retention and tissue distribution of methylmercury six adult female random-bred cats were given a single oral dose of 78 ..mu..g (55 ..mu..Ci) of (/sup 203/Hg)methylmercury chloride. /sup 203/Hg in the whole body of the cats and in feces and urine were monitored for 156 days. Samples of hair collected throughout the experiment were used to correct the whole body radioactivity measurements for the mercury contained in the hair and to adjust the whole body retention for the amount of mercury contained in the hair. Tissue distribution of /sup 203/Hg was measured 156 days postdosing. The ability of various tissues to concentrate methylmercury was expressed as a concentration factor (CF = (specific activity of a tissue at a time t)/(specific activity of the whole cat at time t)). The whole body half-period of methylmercury after a single oral dose of (/sup 203/Hg)methylmercury to cats was 117.7 +- (SE) 1.4 days including the hair and 76.2 +- 1.6 days excluding the hair. The half-period of appearance of methylmercury in hair, feces and urine were 69 +- 5, 68 +- 5, and 78 +- 4 days, respectively. The percentage of the total dose of methylmercury remaining in the cats after 156 days were 35.9 +- 3.3 percent. Hair showed the highest CF(30.2 +- 2.6) followed by liver (12.4 +- 1.0), gall-bladder (2.3 +- 0.5), and kidney (2.0 +- 0.1). Muscle, lymph nodes, hide, and adrenal gland had CF values of approximately 1. The CF for various brain areas ranged between 0.48 and 0.60.

Hollins, J.G.; Willes, R.F.; Bryce, F.R.; Charbonneau, S.M.; Munro, I.C.

1975-01-01T23:59:59.000Z

49

Hydrogen Retention and Release Summary from Tank 48H from September 1995 to October 1996  

DOE Green Energy (OSTI)

This report outlines the results of the investigation with emphasis on the measured hydrogen generation rates and a summary of the hydrogen retention and release behavior.

Peterson, R.A.

1998-09-30T23:59:59.000Z

50

Retention of aerosol particles in the human respiratory tract as a function of particle radius  

SciTech Connect

A water--glycerol aerosol of /sup 24/NaCl (approx. 500 mg/m/sup 3/) was inhaled by 7 volunteers to assess retention of monodispersed aerosols in human respiratory tract. Various particle sizes were tested; dispersion method was thought to be effective. Alveolar retention shows two peaks in the 0.3 to 1 ..mu..m range. Maximum alveolar retention is approx. 45%. Total retention decreased linearly with breathing rate, increased linearly with radius from 0.2 to 1.6 ..mu..m.

Wilson, I.B.; LaMer, V.K.

1948-01-01T23:59:59.000Z

51

Nuclear reactor melt-retention structure to mitigate direct containment heating  

DOE Patents (OSTI)

A light water nuclear reactor melt-retention structure to mitigate the extent of direct containment heating of the reactor containment building. The structure includes a retention chamber for retaining molten core material away from the upper regions of the reactor containment building when a severe accident causes the bottom of the pressure vessel of the reactor to fail and discharge such molten material under high pressure through the reactor cavity into the retention chamber. In combination with the melt-retention chamber there is provided a passageway that includes molten core droplet deflector vanes and has gas vent means in its upper surface, which means are operable to deflect molten core droplets into the retention chamber while allowing high pressure steam and gases to be vented into the upper regions of the containment building. A plurality of platforms are mounted within the passageway and the melt-retention structure to direct the flow of molten core material and help retain it within the melt-retention chamber. In addition, ribs are mounted at spaced positions on the floor of the melt-retention chamber, and grid means are positioned at the entrance side of the retention chamber. The grid means develop gas back pressure that helps separate the molten core droplets from discharged high pressure steam and gases, thereby forcing the steam and gases to vent into the upper regions of the reactor containment building.

Tutu, Narinder K. (Manorville, NY); Ginsberg, Theodore (East Setauket, NY); Klages, John R. (Mattituck, NY)

1991-01-01T23:59:59.000Z

52

Life-Changing Drug Design  

NLE Websites -- All DOE Office Websites (Extended Search)

facilities are aimed at designing more effective drugs with fewer side effects. Life-Changing Drug Design One notable example is vemurafenib, a drug designed by...

53

RETENTION OF SULFATE IN HIGH LEVEL RADIOACTIVE WASTE GLASS  

SciTech Connect

High level radioactive wastes are being vitrified at the Savannah River Site for long term disposal. Many of the wastes contain sulfate at concentrations that can be difficult to retain in borosilicate glass. This study involves efforts to optimize the composition of a glass frit for combination with the waste to improve sulfate retention while meeting other process and product performance constraints. The fabrication and characterization of several series of simulated waste glasses are described. The experiments are detailed chronologically, to provide insight into part of the engineering studies used in developing frit compositions for an operating high level waste vitrification facility. The results lead to the recommendation of a specific frit composition and a concentration limit for sulfate in the glass for the next batch of sludge to be processed at Savannah River.

Fox, K.

2010-09-07T23:59:59.000Z

54

Molecular shape and the prediction of high-performance liquid chromatographic retention indexes of polycyclic aromatic hydrocarbons  

SciTech Connect

The effects of molecular shape on the retention behavior of polycyclic aromatic hydrocarbons (PAH) have been studied. It has been found that the retention on polymeric phases is highly shape dependent in contrast to the monomeric phases where retention is more dependent on the electronic properties of the solute. In addition, retention on the polymeric phases has been studied with respect to substitution and shape. The retention of substituted PAHs shows a strong dependence on shape, whereas the retention of unsubstituted PAHs is more dependent on electronic properties.

Rohrbaugh, R.H.; Jurs, P.C.

1987-04-01T23:59:59.000Z

55

Assessment of gas accumulation and retention -- Tank 241-SY-101  

DOE Green Energy (OSTI)

An approximate analysis has been carried out to assess and estimate the maximum quantity of gas that is likely to be accumulated within waste tank 241-SY-101, and the maximum quantity which is likely to be retained after gas release events (GRE). According to the phenomenological models used for this assessment, based on interpretation of current and recent operational data, the estimated gas generation rate in the tank is approximately 4 m{sup 3}/day (147 ft{sup 3}/day). About half of this gas is released as it is generated, which is (essentially) continuously. The remainder is accumulated within the slurry layer of settled solids at the bottom of the tank, and released episodically in GREs, known as ``burps,`` that are induced by unstable buoyant conditions which develop when sufficient gas accumulates in the slurry. Calculations based on gas volumes to cause neutral buoyancy in the slurry predict the following: the maximum gas accumulation (at 1 atm pressure) that can occur without triggering a GRE is in the range of 606 to 1,039 m{sup 3} (21,400 to 36,700 ft{sup 3}); and the maximum gas retention immediately after a GRE is equal to the maximum accumulation minus the gas released in the GRE. GREs do not necessarily involve all of the slurry. In the largest GREs, which are assumed to involve all of the slurry, the minimum gas release (at 1 atm pressure) is calculated to be in the range of 193 to 328 m{sup 3} (6,800 to 11,600 ft{sup 3}). The corresponding maximum gas retention would be 413 to 711 m{sup 3} (14,600 to 25,100 ft{sup 3}).

Alleman, R.T. [Pacific Northwest Lab., Richland, WA (US); Burke, T.M.; Reynolds, D.A.; Simpson, D.E. [Westinghouse Hanford Co., Richland, WA (US)

1993-03-01T23:59:59.000Z

56

Gas bubble retention and its effect on waste properties: Retention mechanisms, viscosity, and tensile and shear strengths  

SciTech Connect

Several of the underground nuclear storage tanks at Hanford have been placed on a flammable gas watch list, because the waste is either known or suspected to generate, store, and episodically release flammable gases. Because retention and episodic release of flammable gases from these tanks containing radioactive waste slurries are critical safety concerns, Pacific Northwest Laboratory (PNL) is studying physical mechanisms and waste properties that contribute to the episodic gas release from these storage tanks. This study is being conducted for Westinghouse Hanford Company as part of the PNL Flammable Gas project. Previous investigations have concluded that gas bubbles are retained by the slurry or sludge that has settled at the bottom of the tanks; however, the mechanisms responsible for the retention of these bubbles are not well understood. Understanding the rheological behavior of the waste, particularly of the settled sludge, is critical to characterizing the tendency of the waste to retain gas bubbles and the dynamics of how these bubbles are released from the waste. The presence of gas bubbles is expected to affect the rheology of the sludge, specifically its viscosity and tensile and shear strengths, but essentially no literature data are available to assess the effect of bubbles. The objectives of this study were to conduct experiments and develop theories to understand better how bubbles are retained by slurries and sludges, to measure the effect of gas bubbles on the viscosity of simulated slurries, and to measure the effect of gas bubbles on the tensile and shear strengths of simulated slurries and sludges. In addition to accomplishing these objectives, this study developed correlations, based on the new experimental data, that can be used in large-scale computations of waste tank physical phenomena.

Gauglitz, P.A.; Rassat, S.D.; Powell, M.R. [and others

1995-08-01T23:59:59.000Z

57

Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China  

E-Print Network (OSTI)

drug administration, Primaquine, Plasmodium vivax, China *drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China.China’s recent use of focal MDA. The optimal timing, frequency, drug(

2013-01-01T23:59:59.000Z

58

Bushing retention system for thermal medium cooling delivery tubes in a gas turbine rotor  

SciTech Connect

Bushings are provided in counterbores for wheels and spacers for supporting thermal medium cooling tubes extending axially adjacent the rim of the gas turbine rotor. The retention system includes a retaining ring disposed in a groove adjacent an end face of the bushing and which retaining ring projects radially inwardly to prevent axial movement of the bushing in one direction. The retention ring has a plurality of circumferentially spaced tabs along its inner diameter whereby the ring is supported by the lands of the tube maintaining its bushing retention function, notwithstanding operation in high centrifugal fields and rotation of the ring in the groove into other circular orientations.

Mashey, Thomas Charles (Coxsackie, NY)

2002-01-01T23:59:59.000Z

59

Noninvasive quantification of drug delivery from an implantable MEMS device  

E-Print Network (OSTI)

(cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

Johnson, Audrey M., 1976-

2005-01-01T23:59:59.000Z

60

Quantification of absorption, retention and elimination of two different oral doses of vitamin A in Zambian boys using accelerator mass spectrometry  

SciTech Connect

A recent survey indicated that high-dose vitamin A supplements (HD-VAS) had no apparent effect on vitamin A (VA) status of Zambian children <5 y of age. To explore possible reasons for the lack of response to HD-VAS among Zambian children, we quantified the absorption, retention, and urinary elimination of either a single HDVAS (60 mg) or a smaller dose of stable isotope (SI)-labeled VA (5 mg), which was used to estimate VA pool size, in 3-4 y old Zambian boys (n = 4 for each VA dose). A 25 nCi tracer dose of [{sup 14}C{sub 2}]-labeled VA was co-administered with the HD-VAS or SI-labeled VA, and 24-hr stool and urine samples were collected for 3 and 7 consecutive days, respectively, and 24-hr urine samples at 4 later time points. Accelerator Mass Spectrometry (AMS) was used to measure the cumulative excretion of {sup 14}C in stool and urine 3d after dosing to estimate, respectively, absorption and retention of the VAS and SI-labeled VA. The urinary elimination rate (UER) was estimated by plotting {sup 14}C in urine vs. time, and fitting an exponential equation to the data. Estimates of mean absorption, retention and the UER were 83.8 {+-} 7.1%, 76.3 {+-} 6.7%, and 1.9 {+-} 0.6%/d, respectively, for the HD-VAS and 76.5 {+-} 9.5%, 71.1 {+-} 9.4%, and 1.8 {+-} 1.2%/d, respectively for the smaller dose of SI-labeled VA. Estimates of absorption, retention and the UER did not differ by size of the VA dose administered (P=0.26, 0.40, 0.88, respectively). Estimated absorption and retention were negatively associated with reported fever (P=0.011) and malaria (P =0.010). HD-VAS and SI-labeled VA were adequately absorbed, retained and utilized in apparently healthy Zambian preschool-age boys, although absorption and retention may be affected by recent infections.

Aklamati, E K; Mulenga, M; Dueker, S R; Buchholz, B A; Peerson, J M; Kafwembe, E; Brown, K H; Haskell, M J

2009-10-12T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Mercury retention by fly ashes from coal combustion: Influence of the unburned carbon content  

Science Conference Proceedings (OSTI)

The objective of this study was to evaluate the effect of unburned carbon particles present in fly ashes produced by coal combustion on mercury retention. To achieve this objective, the work was divided into two parts. The aim of the first part of the study was to estimate the amount of mercury captured by the fly ashes during combustion in power stations and the relationship of this retention to the unburned carbon content. The second part was a laboratory-scale study aimed at evaluating the retention of mercury concentrations greater than those produced in power stations by fly ashes of different characteristics and by unburned carbon particles. From the results obtained it can be inferred that the unburned carbon content is not the only variable that controls mercury capture in fly ashes. The textural characteristics of these unburned particles and of other components of fly ashes also influence retention.

Lopez-Anton, M.A.; Diaz-Somoano, M.; Martinez-Tarazona, M.R. [CSIC, Oviedo (Spain)

2007-01-31T23:59:59.000Z

62

Retention behavior of dilute polymers in oil sands  

Science Conference Proceedings (OSTI)

Adequate mobility control between fluid banks is a pertinent factor in the successful application of secondary and tertiary oil recovery processes. Favorable mobilities can be obtained by increasing the viscosity or reducing the permeability to the displacing fluid phase. Polyacrylamide and oio-polymers have proved to be useful for these purposes. These polymers increase the water viscosity substantially at low concentrations. The resulting reduced mobility of the displacing phase suppresses the fingering phenomenon and improves piston-like displacement. However, the structural complexity of these polymers coupled with the complexity of the flow channels in the porous medium cause part of these polymers to be retained in the reservoir as the displacing fluid from advances, thereby causing a reduction in the concentration of the polymer solution and consequently a loss of mobility control. In addition to the mechanical filtering, adsorption on the grain surfaces reduce the polymer concentration in the displacing fluid. Behavior of polyacrylamide polymers has been studied extensively. Susceptibility of these polymers to salinity, pH, shear, temperature, etc., is well documented. Mechanical entrapment, retention, degradation and adsorption behavior on porous media, including fired Berea sandstone, bead packs and Ottawa sand have been reported. The present study investigates the adsorption and trapping of polymers in flow experiments through unconsolidated oil field sands. Effects of particle size and mineral content have been studied. Effect of a surfactant slug on polymer-rock interaction is also reported. Corroborative studies have been conducted to study the pressure behavior and high tertiary oil recovery in surfactant dilute-polymer systems.

Kikani, J.; Somerton, W.H.

1988-05-01T23:59:59.000Z

63

Decline in urinary retention incidence in 805 patients after prostate brachytherapy: The effect of learning curve?  

SciTech Connect

Purpose: To evaluate the incidence and factors predictive of acute urinary retention (AUR) in 805 consecutive patients treated with prostate brachytherapy monotherapy and to examine the possible effect of a learning curve. Methods and Materials: Between July 1998 and November 2002, 805 patients were treated with prostate brachytherapy. Low-risk patients (Gleason Score (GS) {<=}6; prostate specific antigen (PSA) {<=}10, and {<=} T2b [UICC 1997]) received implant alone. Patients with prostate volume of 50 cc or more, GS = 7, or PSA = 10 to 15 received 6 months of androgen suppression (AS) with brachytherapy. Patient, treatment, and dosimetric factors examined include baseline prostate symptom score (IPSS), diabetes, vascular disease, PSA, Gleason score, clinical stage, AS, ultrasound planning target volume (PUTV), postimplant prostate volume (obtained with 'Day 30' postimplant CT), CT:PUTV ratio (surrogate for postimplant edema), number of seeds, number of needles, number of seeds per needle, dosimetric parameters (V100, V150, and D90), date of implant (learning curve), and implanting oncologists. Univariate and multivariate analyses were carried out. Results: Acute urinary retention in the first 200 patients was 17% vs. 6.3% in the most recently treated 200 patients (p = 0.002). Overall AUR was 12.7%, and prolonged urinary obstruction incidence (>20 days) was 5%. On multivariate analysis, factors predictive of any AUR include baseline IPSS (p = < 0.004), CT:PUTV ratio (p = < 0.001), PUTV (p = < 0.001), and implant order (learning curve) (p = 0.001). Factors predictive for 'prolonged' catheterization (>20 days) on multivariate analysis include IPSS (p < 0.01), number of needles (p < 0.001), diabetes mellitus (p = 0.048), and CT:PUTV ratio (p < 0.001) Conclusion: Over the years, our AUR rate has fallen significantly (from 17% to 6.3%). On multivariate analysis, highly significant factors include IPSS, PUTV, CT:PUTV ratio (i.e., degree of prostate edema), and order of implant (learning curve). Over the course of the program, we have deliberately reduced the number of needles and OR time per patient, which have potentially minimized intraoperative trauma and may have contributed to less toxicity. A learning curve in prostate brachytherapy programs affect not only the outcome but also the toxicity from the treatment.

Keyes, Mira [Department of Radiation Oncology, Vancouver Cancer Centre, Vancouver, BC (Canada)]. E-mail: mkeyes@bccancer.bc.ca; Schellenberg, Devin [Department of Radiation Oncology, Vancouver Cancer Centre, Vancouver, BC (Canada); Moravan, Veronika M.Sc. [Population and Preventive Oncology, British Columbia Cancer Agency, Vancouver, BC (Canada); McKenzie, Michael [Department of Radiation Oncology, Vancouver Cancer Centre, Vancouver, BC (Canada); Agranovich, Alexander [Fraser Valley Cancer Centre, Vancouver, BC (Canada); Pickles, Tom [Department of Radiation Oncology, Vancouver Cancer Centre, Vancouver, BC (Canada); Wu, Jonn [Department of Radiation Oncology, Vancouver Cancer Centre, Vancouver, BC (Canada); Liu, Mitchell [Fraser Valley Cancer Centre, Vancouver, BC (Canada); Bucci, Joseph M.B.B.S. [Department of Radiation Oncology, St. George Hospital, University of New South Wales, Sydney (Australia); Morris, W. James [Department of Radiation Oncology, Vancouver Cancer Centre, Vancouver, BC (Canada)

2006-03-01T23:59:59.000Z

64

Structural Biology Helps Drug Discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Structural Biology Helps Drug Discovery Print Last year, drug discovery company Plexxikon made front-page news with its highly successful anti-cancer drug, Zelboraf, a product that...

65

Structural Biology Helps Drug Discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Structural Biology Helps Drug Discovery Structural Biology Helps Drug Discovery Print Thursday, 19 July 2012 11:21 Last year, drug discovery company Plexxikon made front-page news...

66

State-of-the-State of Texas Retention of High School Science Teachers  

E-Print Network (OSTI)

Concerns about turnover of highly qualified science teachers have pervaded education stakeholder discussions for several years. Yet little is known about where are we in retaining high science teachers in Texas public schools. The three empirical studies included in this dissertation used mixed research methods to explore data collected by the Policy Research Initiative in Science Education (PRISE) Research Group during the 2007-2010 school years. The first study examined mobility patterns and hiring patterns of high school science teachers after two school years. I used descriptive statistical analyses to investigate relationships between teacher-level variables (i.e., teacher type, age, ethnicity, and gender) and school-level variables (i.e., school size and minority student enrollment proportion) with respect to movement out and into Texas schools. Findings revealed variations in mobility patterns of science teachers, based on size and minority student enrollment proportion of the schools in which they worked. Hiring patterns revealed that schools typically hired young, novice White female teachers regardless of school size or minority student enrollment proportion. The second study explored the relationships between schools’ retention strategies and retention challenges with schools’ science teacher retention rates, respectively. I used multiple regression and descriptive statistical analyses to investigate the relationships between study variables. While regression models predicting science teacher retention were not remarkable, descriptive statistical analyses revealed notable relationships between several school-level variables and school retention status. The third study investigated relationships among three variables: school retention strategies, science teacher job satisfaction, and science teacher mobility. Multilevel analyses were used to investigate relationships between two-level variables. Findings revealed no relationships of significance between school retention strategies or teacher job satisfaction with teacher mobility. However, interactions between predictor variables indicated that satisfied science teachers were more likely to remain at schools that expressed and showed appreciation for teachers than to leave the profession. Findings from these studies were used to make state-, district-, and school-level policy recommendations for high school science teachers that included: (a) tailoring recruitment and retention supports to meet the needs of underrepresented teacher populations leading science classrooms, (b) recognizing schools that successfully retain science teachers, and (c) providing professional development for high school principals to assist with the design of strategic plans to improve job satisfaction and retention of teachers.

Spikes, Sara Elizabeth

2011-08-01T23:59:59.000Z

67

Retention/Diffusivity Studies in Free-Surface Flowing Liquid Lithium  

DOE Green Energy (OSTI)

FLIRE was designed to measure the hydrogen and helium retention and diffusivity in a flowing stream of liquid lithium, and it has accomplished these goals. Retention coefficients for helium in the flowing liquid stream were 0.1-2% for flow speeds of 44 cm/s and implantation energies between 500 and 2000 eV. The energy dependence of retention is linear for the energy range considered, as expected, and the dependence of retention on flow velocity fits the expected square-root of flow speed dependence. Estimates of the helium diffusion coefficient in the flowing lithium stream were {approx} 4 x 10{sup -7} cm{sup 2}/s, and are independent of implantation energy. This value is much lower than expected, which could be due to several factors, such as mixing, bubble formation or surface film formation. In the case of hydrogen, long term retention and release mechanisms are of greatest importance, since this relates to tritium inventory in flowing lithium PFCs for fusion applications. The amount of hydride formation was measured for flowing lithium exposed to neutral deuterium gas. Thermal desorption spectroscopy (TDS) measurements indicate that the hydride concentration was between 0.1 and 0.2% over a wide range of pressures (6.5 x 10{sup -5} to 1 Torr). This result implies that the deuterium absorption rate is limited by the surface dissociation rate, since deuterium (hydrogen/tritium) is absorbed in its atomic form, not its molecular form.

R.A. Stubbers; G.H. Miley; M. Nieto; W. Olczak; D.N. Ruzic; A. Hassanein

2004-12-14T23:59:59.000Z

68

Chemical biology drug discovery  

E-Print Network (OSTI)

Keywords Chemical biology drug discovery high-throughput screening protein ligands proteases novel chemical and biochemical methods for the identification and optimization of protein ligands us of pro- tein ligands. Results of this research are translated into protein-specific, chemical probes

Schüler, Axel

69

Managing time  

Science Conference Proceedings (OSTI)

Professionals overwhelmed with information glut can find hope from new insights about time management.

Peter J. Denning

2011-03-01T23:59:59.000Z

70

Model-based dependability analysis of programmable drug infusion pumps  

Science Conference Proceedings (OSTI)

Infusion pumps are commonly used in home/hospital care to inject drugs into a patient at programmable rates over time. However, in practice, a combination of faults including software errors, mechanical failures and human error can lead to catastrophic ...

Sriram Sankaranarayanan; Hadjar Homaei; Clayton Lewis

2011-09-01T23:59:59.000Z

71

Arsenate and Arsenite Retention and Release in Oxide and Sulfide Dominated Systems  

E-Print Network (OSTI)

Metal pollution of surface water resources in Texas is a significant problem, and is caused by the inflow of sediments from oil fields, old mines and industrial sites, and by the discharge of metal contaminated sewage and industrial effluents. In the preliminary phases of this project we were interested in a range of contaminant metals; however, following early experiments it was determined that emphasis would be given to arsenic due to the importance of several arsenic contaminated sites in east and central Texas. Three important general field and laboratory observations have been made concerning arsenic and have served as a basis for these studies: (1) correlations between metal concentrations of suspended solids or sediments (as measured by the recommended EPA and USGS methods) and metal levels in fish are often poor, (2) metal concentrations in pore waters of bottom sediments are often highly variable (with time and space) and often considerably higher (but sometimes lower) than in the overlying water column, (3) arsenic speciation and solubility are strongly influenced by redox potential. Existing EPA and USGS methods for quantifying the arsenic level of sediment or suspended solids primarily involve digestion by strong acids. While these methods do provide an indication of total concentration of metals, they often do not provide a reliable measure of bioavailability, either directly to aqueous animals or indirectly through the food chain. Inorganic arsenic exists primarily in the +3 or +5 oxidation states (depending on redox potential), and its reactions in soils and sediments are influenced by pH, redox potential, dissolved organic or inorganic components, and sediment colloids (especially Fe sulfides and Fe, Mn, and Al oxides and hydroxides) and organic matter. Arsenic is often concentrated at the surfaces of suspended and sediment colloids (as surface adsorbed and occluded species or possibly as poorly ordered solid solutions). Arsenic (+3 and +5) is bound, by ligand bonding mechanisms, at the surfaces of solid phase Fe, Al and Mn oxides, though there are major descrepencies in the literature concerning the relative bonding strengths of arsenate and arsenite. These reactions at colloidal surfaces strongly influence its availability within the biosphere in oxidized systems. Arsenic (+3) is readily precipitated as As2S3 or coprecipitated in the FeS2 or FeS structure, and these compounds often control the solubility of arsenic in low redox environments. Because of these reactions, arsenic is likely strongly influenced by the presence of inorganic sulfur. The objectives of the study were as follows: 1. To characterize the concentrations and chemical forms of arsenic and the factors which influence its retention and release 2. To evaluate the role of the periodic oxidation/reduction processes that may occur in sediments on retention and release of arsenic 3. To evaluate the probable role of biologically induced processes (e.g., oxidation/reduction, acidification, and ligand exchange) which may influence the mobilization of precipitated or adsorbed arsenic 4. To develop surface dissolution procedures to assess heavy metal mobilization potential in sediments in the aquatic environment, with emphasis on calcareous stream bed sediments. The primary benefit of this study will be to improve procedures for assessing the bioavailability and potential biological hazard of metals in suspended solids and sediments. Accomplishment of these objectives has enabled us to recommend procedures for assessing biohazard potential and ultimately to better monitor aquatic environments.

Loeppert, Richard H.; Jain, Amita; Raven, Klaus; Wang, Jianlin

1997-06-01T23:59:59.000Z

72

Entropic Time  

Science Conference Proceedings (OSTI)

The formulation of quantum mechanics within the framework of entropic dynamics includes several new elements. In this paper we concentrate on one of them: the implications for the theory of time. Entropic time is introduced as a book-keeping device to keep track of the accumulation of changes. One new feature is that, unlike other concepts of time appearing in the so-called fundamental laws of physics, entropic time incorporates a natural distinction between past and future.

Caticha, Ariel [Department of Physics, University at Albany-SUNY, Albany, NY 12222 (United States)

2011-03-14T23:59:59.000Z

73

A magnetic tunnel junction based zero standby leakage current retention flip-flop  

Science Conference Proceedings (OSTI)

Recently, a magnetic tunnel junction (MTJ), which is a strong candidate as a next-generation memory element, has been used not only as a memory cell but also in spintronics logic because of its excellent properties of nonvolatility, no silicon area occupation, ... Keywords: magnetic tunnel junction (MTJ) logic, nonvolatile flip-flop, retention flip-flop, spintronics logic

Kyungho Ryu, Jisu Kim, Jiwan Jung, Jung Pill Kim, Seung H. Kang, Seong-Ook Jung

2012-11-01T23:59:59.000Z

74

REVIEW ARTICLE Pakistan Vet. J., 24(1): 2004 FACTORS CONTRIBUTING TO YOLK RETENTION  

E-Print Network (OSTI)

REVIEW ARTICLE Pakistan Vet. J., 24(1): 2004 46 FACTORS CONTRIBUTING TO YOLK RETENTION IN POULTRY Department of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan ABSTRACT Yolk) stated that it was the commonest cause of early chick mortality in Pakistan. Jordan (1990) and Singh et

Paris-Sud XI, Université de

75

On the long-term retention of geometry-centric digital engineering artifacts  

Science Conference Proceedings (OSTI)

This paper discusses the challenges of long-term preservation of digital geometric models and the engineering processes associated with them. For engineering, design, manufacturing, and physics-based simulation data this requires formats that are accessible ... Keywords: Digital preservation, Knowledge capture, Long-term knowledge retention, Representation, Standards

William C. Regli; Joseph B. Kopena; Michael Grauer

2011-07-01T23:59:59.000Z

76

Recent Advances on Hydrogenic Retention in ITER's Plasma-Facing Materials: BE, C, W.  

SciTech Connect

Management of tritium inventory remains one of the grand challenges in the development of fusion energy and the choice of plasma-facing materials is a key factor for in-vessel tritium retention. The Atomic and Molecular Data Unit of the International Atomic Energy Agency organized a Coordinated Research Project (CRP) on the overall topic of tritium inventory in fusion reactors during the period 2001-2006. This dealt with hydrogenic retention in ITER's plasma-facing materials, Be, C, W, and in compounds (mixed materials) of these elements as well as tritium removal techniques. The results of the CRP are summarized in this article together with recommendations for ITER. Basic parameters of diffusivity, solubility and trapping in Be, C and W are reviewed. For Be, the development of open porosity can account for transient hydrogenic pumping but long term retention will be dominated by codeposition. Codeposition is also the dominant retention mechanism for carbon and remains a serious concern for both Be and C containing layers. Hydrogenic trapping in unirradiated tungsten is low but will increase with ion and neutron damage. Mixed materials will be formed in a tokamak and these can also retain significant amounts of hydrogen isotopes. Oxidative and photon-based techniques for detritiation of plasma-facing components are described.

Skinner, C H; Alimov, Kh; Bekris, N; Causey, R A; Clark, R.E.H.; Coad, J P; Davis, J W; Doerner, R P; Mayer, M; Pisarev, A; Roth, J

2008-03-29T23:59:59.000Z

77

Isotope Effects and Helium Retention Behavior in Vanadium Tritide  

SciTech Connect

The relaxation times of the H, T, and 3He nuclei have been measured in vanadium hydride and tritide samples. Substantial isotope effects in both the phase transition temperatures and diffusion parameters have been found. When compared to hydrides, the tritide samples have lower transition temperatures and faster mobilities. The differences in the occupancies of the interstitial sites are largely responsible for these isotope effects. Most of the helium atoms generated by tritium decay remain trapped in microscopic bubbles formed with the VTx lattice. Evidence is presented for the gradual growth of the helium bubbles over periods of hundreds of days.

Bowman, Jr., R. C.; Attalla, A., and Craft, B. D.

1985-04-01T23:59:59.000Z

78

Strong-Sludge Gas Retention and Release Mechanisms in Clay Simulants  

SciTech Connect

The Hanford Site has 28 double-shell tanks (DSTs) and 149 single-shell tanks (SSTs) containing radioactive wastes that are complex mixes of radioactive and chemical products. The mission of the Department of Energy's River Protection Project is to retrieve and treat the Hanford tank waste for disposal and close the tank farms. A key aspect of the mission is to retrieve and transfer waste from the SSTs, which are at greater risk for leaking, into DSTs for interim storage until the waste is transferred to and treated in the Waste Treatment and Immobilization Plant. There is, however, limited space in the existing DSTs to accept waste transfers from the SSTs, and approaches to overcoming the limited DST space will benefit the overall mission. The purpose of this study is to summarize and analyze the key previous experiment that forms the basis for the relaxed controls and to summarize progress and results on new experiments focused on understanding the conditions that result in low gas retention. The previous large-scale test used about 50 m3 of sediment, which would be unwieldy for doing multiple parametric experiments. Accordingly, experiments began with smaller-scale tests to determine whether the desired mechanisms can be studied without the difficulty of conducting very large experiments. The most significant results from the current experiments are that progressively lower gas retention occurs in tests with progressively deeper sediment layers and that the method of gas generation also affects the maximum retention. Based on the results of this study, it is plausible that relatively low gas retention could occur in sufficiently deep tank waste in DSTs. The current studies and previous work, however, have not explored how gas retention and release will behave when two or more layers with different properties are present.

Gauglitz, Phillip A.; Buchmiller, William C.; Probert, Samuel G.; Owen, Antionette T.; Brockman, Fred J.

2012-02-24T23:59:59.000Z

79

White Oak Creek embayment sediment retention structure design and construction  

SciTech Connect

White Oak Creek is the major surface water drainage throughout the Department of Energy (DOE) Oak Ridge National Laboratory (ORNL). Samples taken from the lower portion of the creek revealed high levels of Cesium 137 and lower level of Cobalt 60 in near surface sediment. Other contaminants present in the sediment included: lead, mercury, chromium, and PCBs. In October 1990, DOE, US Environmental Protection Agency (EPA), and Tennessee Department of Environment and Conservation (TDEC) agreed to initiate a time critical removal action in accordance with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) to prevent the transport of the contaminated sediments into the Clinch River system. This paper discusses the environmental, regulatory, design, and construction issues that were encountered in conducting the remediation work.

Van Hoesen, S.D.; Kimmell, B.L. [Oak Ridge National Lab., TN (United States); Page, D.G.; Wilkerson, R.B. [MK-Ferguson of Oak Ridge Co., TN (United States); Hudson, G.R. [USDOE Oak Ridge Field Office, TN (United States); Kauschinger, J.L. [Ground Engineering Services, Alpharetta, GA (United States); Zocolla, M. [Nashville District, US Army Corps of Engineers, Nashville, TN (United States)

1994-12-31T23:59:59.000Z

80

TIMING APPARATUS  

DOE Patents (OSTI)

The timing device comprises an escapement wheel and pallet, a spring drive to rotate the escapement wheel to a zero position, means to wind the pretensioned spring proportional to the desired signal time, and a cam mechanism to control an electrical signal switch by energizing the switch when the spring has been wound to the desired position, and deenergizing it when it reaches the zero position. This device produces an accurately timed signal variably witain the control of the operator.

Bennett, A.E.; Geisow, J.C.H.

1956-04-17T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

A Discussion of SY-101 Crust Gas Retention and Release Mechanisms  

DOE Green Energy (OSTI)

The flammable gas hazard in Hanford waste tanks was made an issue by the behavior of double-shell Tank (DST) 241-SY-101 (SY-101). Shortly after SY-101 was filled in 1980, the waste level began rising periodically, due to the generation and retention of gases within the slurry, and then suddenly dropping as the gases were released. An intensive study of the tank's behavior revealed that these episodic releases posed a safety hazard because the released gas was flammable, and, in some cases, the volume of gas released was sufficient to exceed the lower flammability limit (LFL) in the tank headspace (Allemann et al. 1993). A mixer pump was installed in SY-101 in late 1993 to prevent gases from building up in the settled solids layer, and the large episodic gas releases have since ceased (Allemann et al. 1994; Stewart et al. 1994; Brewster et al. 1995). However, the surface level of SY-101 has been increasing since at least 1995, and in recent months the level growth has shown significant and unexpected acceleration. Based on a number of observations and measurements, including data from the void fraction instrument (VFI), we have concluded that the level growth is caused largely by increased gas retention in the floating crust. In September 1998, the crust contained between about 21 and 43% void based on VFI measurements (Stewart et al. 1998). Accordingly, it is important to understand the dominant mechanisms of gas retention, why the gas retention is increasing, and whether the accelerating level increase will continue, diminish or even reverse. It is expected that the retained gas in the crust is flammable, with hydrogen as a major constituent. This gas inventory would pose a flammable gas hazard if it were to release suddenly. In May 1997, the mechanisms of bubble retention and release from crust material were the subject of a workshop. The evaluation of the crust and potential hazards assumed a more typical void of roughly 15% gas. It could be similar to percolati on in single-shell tank (SST) waste forms. The much higher void being currently observed in SY-101 represents essentially a new crust configuration, and the mechanisms for sudden gas release need to be evaluated. The purpose of this study is to evaluate the situation of gas bubbles in crust based on the previous work on gas bubble retention, migration, and release in simulants and actual waste. We have also conducted some visual observations of bubble migration through simulated crusts to help understand the interaction of the various mechanisms.

SD Rassat; PA Gauglitz; SM Caley; LA Mahoney; DP Mendoza

1999-02-23T23:59:59.000Z

82

Retention sleeve for a thermal medium carrying tube in a gas turbine  

SciTech Connect

Multiple tubes are connected to steam supply and spent cooling steam return manifolds for supplying cooling steam to buckets and returning spent cooling steam from the buckets to the manifolds, respectively. The tubes are prevented from axial movement in one direction by flanges engaging end faces of the spacer between the first and second-stage wheels. Retention sleeves are disposed about cantilevered ends of the tubes. One end of the retention sleeve engages an enlarged flange on the tube, while an opposite end is spaced axially from an end face of the adjoining wheel, forming a gap, enabling thermal expansion of the tubes and limiting axial displacement of the tube in the opposite direction.

Lathrop, Norman Douglas (Ballston Lake, NY); Czachor, Robert Paul (Cincinnati, OH)

2003-01-01T23:59:59.000Z

83

November 13 - 15, 2012 HSS Work Group Leadership Meeting Summary - Work Force Retention  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Work Force Retention Work Group Work Force Retention Work Group Co-Lead Telecom November 16, 2012 DRAFT Discussion Overview Purpose: This HSS Focus Group Work Group telecom was held with the Work Group Co-Leads to discuss change elements and strategic direction to support accelerated efforts to advancing progress, productivity and performance within each of the Work Groups. Although current roles within all of the Work Groups and Focus Group efforts remain the same, the addition of centralized leadership and oversight by representatives (2) of the Departmental Representative to the Defense Nuclear Facilities Safety Board are established. 1. Leadership Transition * Co-Leads will continue to provide technical functions * Functions of the Focus Group Program will remain the same. [Lily/Stephanie]

84

Effects of Globally Waste Disturbing Activities on Gas Generation, Retention, and Release in Hanford Waste Tanks  

SciTech Connect

Various operations are authorized in Hanford single- and double-shell tanks that disturb all or a large fraction of the waste. These globally waste-disturbing activities have the potential to release a large fraction of the retained flammable gas and to affect future gas generation, retention, and release behavior. This report presents analyses of the expected flammable gas release mechanisms and the potential release rates and volumes resulting from these activities. The background of the flammable gas safety issue at Hanford is summarized, as is the current understanding of gas generation, retention, and release phenomena. Considerations for gas monitoring and assessment of the potential for changes in tank classification and steady-state flammability are given.

Stewart, Charles W.; Fountain, Matthew S.; Huckaby, James L.; Mahoney, Lenna A.; Meyer, Perry A.; Wells, Beric E.

2005-08-02T23:59:59.000Z

85

Rayleigh-Taylor Instability within Sediment Layers Due to Gas Retention: Preliminary Theory and Experiments  

SciTech Connect

In Hanford underground waste storage tanks, a typical waste configuration is settled beds of waste particles beneath liquid layers. The settled beds are typically composed of layers, and these layers can have different physical and chemical properties. One postulated configuration within the settled bed is a less-dense layer beneath a more-dense layer. The different densities can be a result of different gas retention in the layers or different degrees of settling and compaction in the layers. This configuration can experience a Rayleigh-Taylor (RT) instability where the less dense lower layer rises into the upper layer. Previous studies of gas retention and release have not considered potential buoyant motion within a settle bed of solids. The purpose of this report is to provide a review of RT instabilities, discuss predictions of RT behavior for sediment layers, and summarize preliminary experimental observations of RT instabilities in simulant experiments.

Gauglitz, Phillip A.; Wells, Beric E.; Buchmiller, William C.; Rassat, Scot D.

2013-03-21T23:59:59.000Z

86

UIC Developing Drug for SARS  

NLE Websites -- All DOE Office Websites (Extended Search)

but their backbones. When viruses mutate, as they frequently do, thwarting the action of drugs, the mutations typically occur in these sidechains. "By targeting the backbone, we...

87

Investigation of downward facing critical heat flux with water-based nanofluids for In-Vessel Retention applications  

E-Print Network (OSTI)

In-Vessel Retention ("IVR") is a severe accident management strategy that is power limiting to the Westinghouse AP1000 due to critical heat flux ("CHF") at the outer surface of the reactor vessel. Increasing the CHF level ...

DeWitt, Gregory L

2011-01-01T23:59:59.000Z

88

Investigation of downward facing critical heat flux with water-based nanofluids for In-Vessel Retention applications.  

E-Print Network (OSTI)

??In-Vessel Retention ("IVR") is a severe accident management strategy that is power limiting to the Westinghouse AP1000 due to critical heat flux ("CHF") at the… (more)

DeWitt, Gregory L

2011-01-01T23:59:59.000Z

89

Investigation of the use of nanofluids to enhance the In-Vessel Retention capabilities of Advanced Light Water Reactors  

E-Print Network (OSTI)

Nanofluids at very low concentrations experimentally exhibit a substantial increase in Critical Heat Flux (CHF) compared to water. The use of a nanofluid in the In-Vessel Retention (IVR) severe accident management strategy, ...

Hannink, Ryan Christopher

2007-01-01T23:59:59.000Z

90

Digestion time  

NLE Websites -- All DOE Office Websites (Extended Search)

Digestion time Digestion time Name: Don Mancosh Location: N/A Country: N/A Date: N/A Question: I have always given the rule of thumb in class that material we eat is with us for about 24 hours before exiting the body. The question arises about the time value of liquids. Getting a big coke prior to a 3 hour drive generally means that there will be a stop along the way. Is there a generalization made about liquids in the body similar to the one for solid food? Replies: A physician would give a better answer, but I hazard this: the only liquids which people consume (deliberately) in significant quantities are water, ethyl alcohol and various oils. Water and alcohol are absorbed on a time scale of seconds to minutes through the mouth, stomach and digestive tract. The oils are huge molecules, so I'd guess like any other greasy food they get absorbed in the upper digestive tract. Some of them, perhaps the longest and most nonpolar, are not absorbed at all --- cf. the old-time remedy of mineral oil for constipation --- so there should be some average time-before-what's-left-is-excreted such as you're looking for, and my (wild) guess is that it would not differ substantially from that for food. You can define an average lifetime in the body for alcohol, since the natural level is zero. Rough guidelines are widespread in the context of drunk driving laws. But this is not really possible for water. One's body is normally full up to the brim with water, and there's no way for the body to distinguish between water molecules recently absorbed and molecules that've been moping around since the Beatles split up. Thus the water entering the toilet bowl after the pit stop is not in general the same water as was in the big coke. If you were to consider for water just the average time between drinking and peeing, it would seem to depend strongly on how well hydrated the body was before the drink, and how much was drunk. During sustained heavy exertion in the sun and dry air one can easily drink a pint of water an hour without peeing at all. On the other hand, if one is willing to drink enough water fast enough, so as to establish a high excess of body water one can pee 8 ounces 15 minutes or less after drinking 8 ounces.

91

SUMMARY OF FY11 SULFATE RETENTION STUDIES FOR DEFENSE WASTE PROCESSING FACILITY GLASS  

Science Conference Proceedings (OSTI)

This report describes the results of studies related to the incorporation of sulfate in high level waste (HLW) borosilicate glass produced at the Savannah River Site (SRS) Defense Waste Processing Facility (DWPF). A group of simulated HLW glasses produced for earlier sulfate retention studies was selected for full chemical composition measurements to determine whether there is any clear link between composition and sulfate retention over the compositional region evaluated. In addition, the viscosity of several glasses was measured to support future efforts in modeling sulfate solubility as a function of predicted viscosity. The intent of these studies was to develop a better understanding of sulfate retention in borosilicate HLW glass to allow for higher loadings of sulfate containing waste. Based on the results of these and other studies, the ability to improve sulfate solubility in DWPF borosilicate glasses lies in reducing the connectivity of the glass network structure. This can be achieved, as an example, by increasing the concentration of alkali species in the glass. However, this must be balanced with other effects of reduced network connectivity, such as reduced viscosity, potentially lower chemical durability, and in the case of higher sodium and aluminum concentrations, the propensity for nepheline crystallization. Future DWPF processing is likely to target higher waste loadings and higher sludge sodium concentrations, meaning that alkali concentrations in the glass will already be relatively high. It is therefore unlikely that there will be the ability to target significantly higher total alkali concentrations in the glass solely to support increased sulfate solubility without the increased alkali concentration causing failure of other Product Composition Control System (PCCS) constraints, such as low viscosity and durability. No individual components were found to provide a significant improvement in sulfate retention (i.e., an increase of the magnitude necessary to have a dramatic impact on blending, washing, or waste loading strategies for DWPF) for the glasses studied here. In general, the concentrations of those species that significantly improve sulfate solubility in a borosilicate glass must be added in relatively large concentrations (e.g., 13 to 38 wt % or more of the frit) in order to have a substantial impact. For DWPF, these concentrations would constitute too large of a portion of the frit to be practical. Therefore, it is unlikely that specific additives may be introduced into the DWPF glass via the frit to significantly improve sulfate solubility. The results presented here continue to show that sulfate solubility or retention is a function of individual glass compositions, rather than a property of a broad glass composition region. It would therefore be inappropriate to set a single sulfate concentration limit for a range of DWPF glass compositions. Sulfate concentration limits should continue to be identified and implemented for each sludge batch. The current PCCS limit is 0.4 wt % SO{sub 4}{sup 2-} in glass, although frit development efforts have led to an increased limit of 0.6 wt % for recent sludge batches. Slightly higher limits (perhaps 0.7-0.8 wt %) may be possible for future sludge batches. An opportunity for allowing a higher sulfate concentration limit at DWPF may lay lie in improving the laboratory experiments used to set this limit. That is, there are several differences between the crucible-scale testing currently used to define a limit for DWPF operation and the actual conditions within the DWPF melter. In particular, no allowance is currently made for sulfur partitioning (volatility versus retention) during melter processing as the sulfate limit is set for a specific sludge batch. A better understanding of the partitioning of sulfur in a bubbled melter operating with a cold cap as well as the impacts of sulfur on the off-gas system may allow a higher sulfate concentration limit to be established for the melter feed. This approach would have to be taken carefully to ensure that a

Fox, K.; Edwards, T.

2012-05-08T23:59:59.000Z

92

Soil Water Retention and Relative Permeability for Conditions from Oven-Dry to Full Saturation  

SciTech Connect

Common conceptual models for unsaturated flow often rely on the oversimplified representation of medium pores as a bundle of cylindrical capillaries and assume that the matric potential is attributed to the capillary force only. The adsorptive surface forces are ignored. It is often assumed that aqueous flow is negligible when a soil is near or at the residual water content. These models are successful at high and medium water contents but often give poor results at low water contents. These models do not apply to conditions at which the water content is less than the residual water content. We extend the lower bound of existing water-retention functions and conductivity models from residual water content to the oven-dry condition (i.e., zero water content) by defining a state-dependent, residual-water content for a soil drier than a critical value. Furthermore, a hydraulic conductivity model for smooth uniform spheres was modified by introducing a correction factor to describe the film flow-induced hydraulic conductivity for natural porous media. The total unsaturated hydraulic conductivity is the sum of those due to capillary and film flow. The extended retention and conductivity models were verified measurements. Results show that, when the soil is at high and intermediate water content, there is no difference between the un-extended and the extended models; when the soil is at low water content, the un-extended models overestimate the water content but underestimate the conductivity. The extended models match the retention and conductivity measurements well.

Zhang, Z. F.

2011-11-04T23:59:59.000Z

93

Soil Water Retention and Relative Permeability for Full Range of Saturation  

SciTech Connect

Common conceptual models for unsaturated flow often rely on the oversimplified representation of medium pores as a bundle of cylindrical capillaries and assume that the matric potential is attributed to capillary forces only. The adsorptive surface forces are ignored. It is often assumed that aqueous flow is negligible when a soil is near or at the residual water content. These models are successful at high and medium water contents but often give poor results at low water contents. These models do not apply to conditions at which water content is less than the residual water content. We extend the lower bound of existing water-retention functions and conductivity models from residual water content to the oven-dry condition (i.e., zero water content) by defining a state-dependent, residual-water content for a soil drier than a critical value. Furthermore, a hydraulic conductivity model for smooth uniform spheres was modified by introducing a correction factor to describe the film flow-induced hydraulic conductivity for natural porous media. The total unsaturated hydraulic conductivity is the sum of those due to capillary and film flow. The extended retention and conductivity models were verified with six datasets from the literature. Results show that, when the soil is at high and intermediate water content, there is no difference between the un-extended and the extended models; when the soil is at low water content, the un-extended models overestimate the water content but under-estimate the conductivity while the extended models match the retention and conductivity measurements well.

Zhang, Z. F.

2010-09-28T23:59:59.000Z

94

Computer-Aided Drug Target Search  

E-Print Network (OSTI)

Identification of the unknown targets of drugs, investigative drugs and herbal ingredients is an important task in drug discovery. It can potentially help in several aspects including: (1) determination of unknown therapeutic ...

Chen, Yuzong

95

Axial thermal medium delivery tubes and retention plates for a gas turbine rotor  

SciTech Connect

In a multi-stage turbine rotor, tubes are disposed in openings adjacent the rotor rim for flowing a thermal medium to rotor buckets and returning spent thermal medium. The tubes have axially spaced lands of predetermined wall thickness with thin-walled tube sections between the lands and of increasing thickness from the forward to the aft ends of the tubes. A pair of retention plates are carried on the aft end face of the aft wheel and straddle the tube and engage against a shoulder on the tube to preclude displacement of the tube in an aft direction.

Mashey, Thomas Charles (Coxsackie, NY)

2002-01-01T23:59:59.000Z

96

Time Brightness  

NLE Websites -- All DOE Office Websites (Extended Search)

Perlmutter, et al., in Thermonuclear Supernovae, NATO ASI, v. 486 (1997) Perlmutter, et al., in Thermonuclear Supernovae, NATO ASI, v. 486 (1997) Cosmology from . . . Time Brightness ... . . . 50-100 Fields Lunar Calendar Scheduled Follow-Up Imaging at Hubble, Cerro Tololo, WIYN, Isaac Newton Scheduled Follow-Up Spectroscopy at Keck Almost 1000 Galaxies per Field RESULT: ~24 Type Ia supernovae discovered while still brightening, at new moon Berkeley Lab Keck WIYN Cerro Tololo Isaac Newton Hubble Strategy We developed a strategy to guarantee a group of supernova discoveries on a certain date. Just after a new moon, we observe some 50 to 100 high-galactic lattitute fields-each containing almost a thousand high-redshift galaxies-in two nights on the Cerro Tololo 4-meter telescope with Tyson & Bernstein's wide-field camera. We return three weeks later to observe the same

97

RETENTION AND CHEMICAL SPECIATION OF URANIUM IN A WETLAND ON THE SAVANNAH RIVER SITE  

SciTech Connect

Uranium speciation and retention mechanism onto Savannah River Site (SRS) wetland sediments was studied using batch (ad)sorption experiments, sequential extraction desorption tests and U L{sub 3}-edge X-ray absorption near-edge structure (XANES) spectroscopy of contaminated wetland sediments. U was highly retained by the SRS wetland sediments. In contrast to other similar but much lower natural organic matter (NOM) sediments, significant sorption of U onto the SRS sediments was observed at pH <4 and pH >8. Sequential extraction tests indicated that the U(VI) species were primarily associated with the acid soluble fraction (weak acetic acid extractable) and NOM fraction (Na-pyrophosphate extractable). Uranium L3- edge XANES spectra of the U-retained sediments were nearly identical to that of uranyl acetate. The primary oxidation state of U in these sediments was as U(VI), and there was little evidence that the high sorptive capacity of the sediments could be ascribed to abiotic or biotic reduction to the less soluble U(IV) species. The molecular mechanism responsible for the high U retention in the SRS wetland sediments is likely related to the chemical bonding of U to organic carbon.

Li, D.; CHANG, H.: SEAMAN, J.; Jaffe, P.; Groos, P.; Jiang, D.; Chen, N.; Lin, J.; Arthur, Z.; Scheckel, K.; Kaplan, D.

2013-06-17T23:59:59.000Z

98

Radionuclide Retention Mechanisms in Secondary Waste-Form Testing: Phase II  

SciTech Connect

This report describes the results from laboratory tests performed at Pacific Northwest National Laboratory (PNNL) for Washington River Protection Solutions (WRPS) to evaluate candidate stabilization technologies that have the potential to successfully treat liquid secondary waste stream effluents produced by the Hanford Tank Waste Treatment and Immobilization Plant (WTP). WRPS is considering the design and construction of a Solidification Treatment Unit (STU) for the Effluent Treatment Facility (ETF) at Hanford. The ETF, a multi-waste, treatment-and-storage unit that has been permitted under the Resource Conservation and Recovery Act (RCRA), can accept dangerous, low-level, and mixed wastewaters for treatment. The STU needs to be operational by 2018 to receive secondary liquid waste generated during operation of the WTP. The STU will provide the additional capacity needed for ETF to process the increased volume of secondary waste expected to be produced by WTP. This report on radionuclide retention mechanisms describes the testing and characterization results that improve understanding of radionuclide retention mechanisms, especially for pertechnetate, {sup 99}TcO{sub 4}{sup -} in four different waste forms: Cast Stone, DuraLith alkali aluminosilicate geopolymer, encapsulated fluidized bed steam reforming (FBSR) product, and Ceramicrete phosphate bonded ceramic. These data and results will be used to fill existing data gaps on the candidate technologies to support a decision-making process that will identify a subset of the candidate waste forms that are most promising and should undergo further performance testing.

Um, Wooyong; Valenta, Michelle M.; Chung, Chul-Woo; Yang, Jungseok; Engelhard, Mark H.; Serne, R. Jeffrey; Parker, Kent E.; Wang, Guohui; Cantrell, Kirk J.; Westsik, Joseph H.

2011-09-26T23:59:59.000Z

99

RETENTION AND CHEMICAL SPECIATION OF URANIUM IN A WETLAND ON THE SAVANNAH RIVER SITE  

Science Conference Proceedings (OSTI)

Uranium speciation and retention mechanism onto Savannah River Site (SRS) wetland sediments was studied using batch (ad)sorption experiments, sequential extraction desorption tests and U L{sub 3}-edge X-ray absorption near-edge structure (XANES) spectroscopy of contaminated wetland sediments. U was highly retained by the SRS wetland sediments. In contrast to other similar but much lower natural organic matter (NOM) sediments, significant sorption of U onto the SRS sediments was observed at pH 8. Sequential extraction tests indicated that the U(VI) species were primarily associated with the acid soluble fraction (weak acetic acid extractable) and NOM fraction (Na-pyrophosphate extractable). Uranium L3- edge XANES spectra of the U-retained sediments were nearly identical to that of uranyl acetate. The primary oxidation state of U in these sediments was as U(VI), and there was little evidence that the high sorptive capacity of the sediments could be ascribed to abiotic or biotic reduction to the less soluble U(IV) species. The molecular mechanism responsible for the high U retention in the SRS wetland sediments is likely related to the chemical bonding of U to organic carbon.

Li, D.; CHANG, H.: SEAMAN, J.; Jaffe, P.; Groos, P.; Jiang, D.; Chen, N.; Lin, J.; Arthur, Z.; Scheckel, K.; Kaplan, D.

2013-06-17T23:59:59.000Z

100

Study of physical properties, gas generation and gas retention in simulated Hanford waste  

DOE Green Energy (OSTI)

The purpose of this study was to establish the chemical and physical processes responsible for the generation and retention of gases within high-level waste from Tank 101-SY on the Hanford Site. This research, conducted using simulated waste on a laboratory scale, supports the development of mitigation/remediation strategies for Tank 101-SY. Simulated waste formulations are based on actual waste compositions. Selected physical properties of the simulated waste are compared to properties of actual Tank 101-SY waste samples. Laboratory studies using aged simulated waste show that significant gas generation occurs thermally at current tank temperatures ({approximately}60{degrees}C). Gas compositions include the same gases produced in actual tank waste, primarily N{sub 2}, N{sub 2}O, and H{sub 2}. Gas stoichiometries have been shown to be greatly influenced by several organic and inorganic constituents within the simulated waste. Retention of gases in the simulated waste is in the form of bubble attachment to solid particles. This attachment phenomenon is related to the presence of organic constituents (HEDTA, EDTA, and citrate) of the simulated waste. A mechanism is discussed that relates the gas bubble/particle interactions to the partially hydrophobic surface produced on the solids by the organic constituents.

Bryan, S.A.; Pederson, L.R.; Scheele, R.D.

1993-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Mechanisms of gas retention and release: Experimental results for Hanford waste tanks 241-AW-101 and 241-AN-103  

DOE Green Energy (OSTI)

The 177 storage tanks at Hanford contain a vast array of radioactive waste forms resulting, primarily, from nuclear materials processing. Through radiolytic, thermal, and other decomposition reactions of waste components, gaseous species including hydrogen, ammonia, and the oxidizer nitrous oxide are generated within the waste tanks. Many of these tanks are known to retain and periodically release quantities of these flammable gas mixtures. The primary focus of the Flammable Gas Project is the safe storage of Hanford tank wastes. To this end, we strive to develop an understanding of the mechanisms of flammable gas retention and release in Hanford tanks through laboratory investigations on actual tank wastes. These results support the closure of the Flammable Gas Unreviewed Safety Question (USQ) on the safe storage of waste tanks known to retain flammable gases and support resolution of the broader Flammable Gas Safety Issue. The overall purpose of this ongoing study is to develop a comprehensive and thorough understanding of the mechanisms of flammable gas retention and release. The first objective of the current study was to classify bubble retention and release mechanisms in two previously untested waste materials from Tanks 241-AN-103 (AN-103) and 241-AW-101 (AW-101). Results were obtained for retention mechanisms, release characteristics, and the maximum gas retention. In addition, unique behavior was also documented and compared with previously studied waste samples. The second objective was to lengthen the duration of the experiments to evaluate the role of slowing bubble growth on the retention and release behavior. Results were obtained for experiments lasting from a few hours to a few days.

Rassat, S.D.; Gauglitz, P.A.; Bredt, P.R.; Mahoney, L.A.; Forbes, S.V.; Tingey, S.M.

1997-09-01T23:59:59.000Z

102

Analysis of Assembly Bill 369: Prescription Drugs  

E-Print Network (OSTI)

health treatment; prescription drugs; rehabilitative and habilitative services and devices; laboratory

California Health Benefits Review Program (CHBRP)

2011-01-01T23:59:59.000Z

103

May 21, 2012, Office of Health, Safety and Security (HSS) Focus Group Work Force Retention Work Group Charter  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Work Force Retention Work Group Charter Work Force Retention Work Group Charter In an ongoing effort to further the improvement of health, safety, environmental, and security performance within the Department, DOE is engaged in the establishment of work groups to pursue health and safety improvements across the DOE Complex. These efforts support DOE's responsibility as owner/manager to protect its greatest asset: the worker. The work groups support DOE's integrated safety management system and further DOE's best interests by fostering worker involvement and partnerships to maximize continuity of operations and the success of the Department's national security mission.

104

Drug Use and Drug Policy in a Prohibition Regime  

E-Print Network (OSTI)

Heroin/opiates MacCoun and Martin - 2/4/2008 - 41 Otherstory_268000326.html. MacCoun and Martin - 2/4/2008 - 29Toward a drugs MacCoun and Martin - 2/4/2008 - 32 and crime

MacCoun, Robert; Martin, Karin D.

2008-01-01T23:59:59.000Z

105

Transfer Retention at City College in Engineering (TRACC). Final report, September 30, 1992--September 29, 1993  

Science Conference Proceedings (OSTI)

Goal of TRACC (Transfer Retention at City College in Engineering) is to increase the number of minority transfer students from community colleges who receive Bachelors degrees in engineering and computer science from CCNY. TRACC offers qualified students access to academic and social support services. TRACC has shown promising results in its first year; TRACC student pass rates in coursework were higher compared to a cohort group of non-TRACC students. They report that tutoring and enrichment courses are valuable and contribute to better performance in classes. The advisement process is utilized and is seen as beneficial. Other services provided by TRACC are viewed by students as contributing to overall career development and enhanced social life at CCNY. TRACC was the College`s first attempt to address the needs of transfer students.

Brown, A.R.

1993-11-01T23:59:59.000Z

106

The effects of computer-assisted instruction on the achievement, attitudes and retention of fourth grade mathematics students in North Cyprus  

Science Conference Proceedings (OSTI)

The purpose of this study was to examine the effects of the educational software Frizbi Mathematics 4 on 4th grade student's mathematics achievement, retention, attitudes toward mathematics and attitude toward computer assisted learning. Two groups (experimental ... Keywords: Attitude towards mathematics, Computer-assisted instruction, Educational software, Mathematics achievement, Retention

Olga Pilli; Meral Aksu

2013-03-01T23:59:59.000Z

107

The Mate Retention Inventory-Short Form (MRI-SF) David M. Buss a,*, Todd K. Shackelford b  

E-Print Network (OSTI)

The Mate Retention Inventory-Short Form (MRI-SF) David M. Buss a,*, Todd K. Shackelford b , William devoted to retaining a mate (Buss, 1988b; Buss & Shackelford, 1997). For many species, long-term mate non-married couples (Buss, 1988a, 1988b) as well as newlywed couples (Buss & Shackelford, 1997). Men

Pillow, Jonathan

108

Pakistan Vt. ./., 22(4): 2002 A STUDY ON THE PATHOGENESIS OF YOLK RETENTION IN BROILER CHICKS  

E-Print Network (OSTI)

Pakistan Vêt. ./., 22(4): 2002 A STUDY ON THE PATHOGENESIS OF YOLK RETENTION IN BROILER CHICKS Laboratories Complex. Lahore, Pakistan ABSTRACT The présent project was designed to identify thé factors commonest cause of early chick mortality in Pakistan (Anjum, 1997). Whcn thé chick émerges from it's shell

Paris-Sud XI, Université de

109

Flow cytometry aids basic cell biology research and drug discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Life Technologies Corporation and LANL have released the Attune® Acoustic Focusing Cytometer, featuring a reduced footprint, reduced consumables, and an affordable price. April 3, 2012 Attune® Acoustic Focusing Cytometer The Attune® Acoustic Focusing Cytometer achieves sample throughput at rates over 10 times faster than other cytometers-up to 1,000 μL per minute. In December 2009, Life Technologies Corporation announced the release of the Attune® Acoustic Focusing Cytometer, a first-of-its-kind cytometer system based on technology developed at Los Alamos National Laboratory (LANL). Examining cells has never been clearer with LANL's use of acoustic waves

110

A bright idea? : the promise and peril of a memory drug  

E-Print Network (OSTI)

In the MIT lab of neuropharmacologist Richard Wurtman, rodents that received a new Alzheimer's drug have shown a marked improvement in learning and memory. They are able to master elaborate mazes in half the time of their ...

Dowd, William (William Michael)

2007-01-01T23:59:59.000Z

111

Linking Error, Passage of Time, the Cerebellum and the Primary Motor Cortex to the Multiple Timescales of Motor Memory By  

E-Print Network (OSTI)

Recently, our laboratory proposed that a single model could account for a large body of behavioral data in numerous motor adaptation paradigms. The idea was that motor memory is supported by at least two interacting processes: a fast process that learns quickly from motor error but rapidly forgets, and a slow process that only gradually learns from error but has long-term retention. The main purpose of this research is to uncover the time and error-dependent properties of these putative processes and to ask whether there is a link between these processes and the functions of the cerebellum and primary motor cortex. How does passage of time affect retention of motor memories? The typical approach is to learn a task, and then look at retention as a function of time. However, if motor memories are supported by multiple processes, then a better way to reveal their timescales is to adapt, reverse adapt, and then quantify retention. The prediction of our theory is that there should be spontaneous recovery of the initial adaptation with passage of time. Because theory predicts that reverse adaptation will primarily engage the fast

Sarah Hemminger; Sarah Hemminger

2010-01-01T23:59:59.000Z

112

Packaging for a drug delivery microelectromechanical system  

E-Print Network (OSTI)

Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

Ho Duc, Hong Linh, 1978-

2005-01-01T23:59:59.000Z

113

Anion retention in soil: Possible application to reduce migration of buried technetium and iodine  

SciTech Connect

This report summarizes a literature review of our present knowledge of the anion exchange properties of a number of soils and minerals, which may potentially be used as anion exchangers to retard migration of such anions as iodide (I{sup {minus}}), iodate (IO{sub 3}{sup {minus}}) and pertechnetate (TcO{sub 4}{sup {minus}}) away from disposal site. The amorphous clays allophane and imogolite, are found to be among the most important soil components capable of developing appreciable amounts of positive charge for anion exchange even at about neutral pH. Decreases in the SiO{sub 2}/Al{sub 2}O{sub 3} ratio and soil pH result in an increase in soil AEC. Allophane and imogolite rich soils have an AEC ranging from 1 to 18 meq/100g at pH about 6. Highly weathered soils dominated by Fe and Al oxides and kaolinite may develop a significant amount of AEC as soil pH falls. The retention of iodine (I) and technetium ({Tc}), by soils is associated with both soil organic matter, and Fe and Al oxides, whereas sorption on layer silicate minerals in negligible. Fe and Al oxides become more important in the retention of anionic I{sup {minus}}, IO{sub 3}{sup {minus}}, and TcO{sub 4}{sup {minus}} as pH falls, since more positive charge is developed on the oxide surfaces. Although few studies, if any, have been conducted on I and {Tc} sorption by soil allophane and imogolite, it is estimated that a surface plough soil (2 million pounds soil per acre) with 5 meq/100g AEC, as is commonly found in andisols, shall retain approximately 5900 kg I and 4500 kg {Tc}. It is conceivable that an anion exchanger such as an andisol could be used to modify the near field environment of a radioactive waste disposal facility. This whole disposal system would then offer similar migration resistance to anions as is normally afforded to cations by usual and normal soils. 93 refs., 10 figs., 7 tabs.

Gu, B.; Schulz, R.K. (California Univ., Berkeley, CA (United States). Dept. of Soil Science)

1991-10-01T23:59:59.000Z

114

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

115

The pipeline and future of drug development in schizophrenia  

E-Print Network (OSTI)

The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

Gray, J A; Roth, B L

2007-01-01T23:59:59.000Z

116

Teacher Participation in Professional Activities and Job Satisfaction: Prevalence and Associative Relationship to Retention for High School Science Teachers  

E-Print Network (OSTI)

In this dissertation, I used survey response data from 385 science teachers situated in 50 randomly selected Texas high schools to describe the prevalence of high school science teacher participation in professional activities and levels of job satisfaction. Using relative risk statistics, I determined the direction and significance of multiple associative relationships involving teachers’ participation in professional activities, satisfaction with working conditions, and retention state. Finally, I used these results to make specific policy recommendations. Teachers participate in diverse professional activities. Descriptive analyses of responses from teachers revealed higher rates of participation in development activities than in maintenance or management activities. Relative risk statistics exposed several positive and significant associative relationships between participation in specific professional activities (i.e., observation of other science teachers, involvement in a science education study group) and teacher retention. Additionally, results of risk analyses suggest teacher participation in maintenance activities, more than development or management, is associated with teacher retention. Researchers consider job satisfaction an important factor in teacher retention. Descriptive analyses revealed high rates of satisfaction with occupational choice and the interpersonal relationships shared with professional colleagues and administrators. Conversely, teachers expressed low rates of satisfaction with their school’s science laboratory facilities and equipment or support for student involvement in informal science activities. Results of risk analyses exposed no positive associations between job satisfaction and retention for teachers. The interaction between teacher participation in professional activities and satisfaction with occupational choice was also examined. Descriptive analyses of responses from retained teachers (n=291) revealed high rates of participation in development activities in comparison to maintenance or management activities. Results of risk analyses exposed both positive and negative associations between teacher participation in professional activities and satisfaction with occupational choice, suggesting an interactive effect exists between participation in activities and satisfaction with occupational choice on retention. I used results from analyses to make state and school level policy recommendations, which included: (a) development of state standards for classroom equipment and facilities; (b) greater state involvement in defining teacher professional activities; and, (c) increasing school support for teacher participation in maintenance activities.

Bozeman, Todd Dane

2010-12-01T23:59:59.000Z

117

Simulation of water flow and retention in earthen-cover materials overlying uranium mill tailings  

SciTech Connect

The water retention characteristics of a multilayer earthen cover for uranium mill tailings were simulated under arid weather conditions common to Grand Junction, Colorado. The multilayer system described in this report consists of a layer of wet clay/gravel (radon barrier), which is separated from a surface covering of fill soil by a washed rock material used as a capillary barrier. The capillary barrier is designed to prevent the upward migration of water and salt from the tailings to the soil surface and subsequent loss of water from the wet clay. The flow model, UNSATV, described in this report uses hydraulic properties of the layered materials and historical climatic data for two years (1976 and 1979) to simulate long-term hydrologic response of the multilayer system. Application of this model to simulate the processes of infiltration, evaporation and drainage is described in detail. Simulations over a trial period of one relatively wet and two dry years indicated that the clay-gravel layer remained near saturation, and hence, that the layer was an effective radon barrier. Estimates show that the clay-gravel layer would not dry out (i.e., revert to drying dominated by isothermal vapor-flow conditions) for at least 20 years, provided that the modeled dry-climate period continues.

Simmons, C.S.; Gee, G.W.

1981-09-01T23:59:59.000Z

118

In-vessel coolability and retention of a core melt. Volume 2  

Science Conference Proceedings (OSTI)

The efficacy of external flooding of a reactor vessel as a severe accident management strategy is assessed for an AP600-like reactor design. The overall approach is based on the Risk Oriented Accident Analysis Methodology (ROAAM), and the assessment includes consideration of bounding scenarios and sensitivity studies, as well as arbitrary parametric evaluations that allow the delineation of the failure boundaries. Quantification of the input parameters is carried out for an AP600-like design, and the results of the assessment demonstrate that lower head failure is physically unreasonable. Use of this conclusion for any specific application is subject to verifying the required reliability of the depressurization and cavity-flooding systems, and to showing the appropriateness (in relation to the database presented here, or by further testing as necessary) of the thermal insulation design and of the external surface properties of the lower head, including any applicable coatings. The AP600 is particularly favorable to in-vessel retention. Some ideas to enhance the assessment basis as well as performance in this respect, for applications to larger and/or higher power density reactors are also provided.

Theofanous, T.G.; Liu, C.; Additon, S.; Angelini, S.; Kymaelaeinen, O.; Salmassi, T. [California Univ., Santa Barbara, CA (United States). Center for Risk Studies and Safety

1996-10-01T23:59:59.000Z

119

Preliminary Study of Strong-Sludge Gas Retention and Release Mechanisms in Clay Simulants  

SciTech Connect

The Hanford Site has 28 double-shell tanks (DSTs) and 149 single-shell tanks (SSTs) containing radioactive wastes that are complex mixes of radioactive and chemical products. The mission of the Department of Energy’s River Protection Project is to retrieve and treat the Hanford tank waste for disposal and close the tank farms. A key aspect of the mission is to retrieve and transfer waste from the SSTs, which are at greater risk for leaking, into DSTs for interim storage until the waste is transferred to and treated in the Waste Treatment and Immobilization Plant. There is, however, limited space in the existing DSTs to accept waste transfers from the SSTs, and approaches to overcoming the limited DST space will benefit the overall mission. The purpose of this study is to summarize and analyze the key previous experiment that forms the basis for the relaxed controls and to summarize initial progress and results on new experiments focused on understanding the conditions that result in low gas retention. The work is ongoing; this report provides a summary of the initial findings. The previous large-scale test used about 50 m3 of sediment, which would be unwieldy for doing multiple parametric experiments. Accordingly, experiments will begin with smaller-scale tests to determine whether the desired mechanisms can be studied without the difficulty of conducting very large experiments.

Gauglitz, Phillip A.; Buchmiller, William C.; Probert, Samuel G.; Owen, Antionette T.

2010-10-12T23:59:59.000Z

120

In-Vessel Retention of Molten Corium: Lessons Learned and Outstanding Issues  

Science Conference Proceedings (OSTI)

In-vessel retention (IVR) of core melt is a key severe accident management strategy adopted by some operating nuclear power plants and proposed for some advanced light water reactors (ALWRs). If there were inadequate cooling during a reactor accident, a significant amount of core material could become molten and relocate to the lower head of the reactor vessel, as happened in the Three Mile Island Unit 2 (TMI-2) accident. If it is possible to ensure that the vessel head remains intact so that relocated core materials are retained within the vessel, the enhanced safety associated with these plants can reduce concerns about containment failure and associated risk. For example, the enhanced safety of the Advanced 600 MWe Pressurized Water Reactor (PWR) designed by Westinghouse (AP600), which relied upon External Reactor Vessel Cooling (ERVC) for IVR, resulted in the U.S. Nuclear Regulatory Commission (US NRC) approving the design without requiring certain conventional features common to existing Light Water Reactors (LWRs). However, it is not clear that the ERVC proposed for the AP600 could provide sufficient heat removal for higher-power reactors (up to 1500 MWe) without additional enhancements. This paper reviews efforts made and results reported regarding the enhancement of IVR in LWRs. Where appropriate, the paper identifies what additional data or analyses are needed to demonstrate that there is sufficient margin for successful IVR in high power thermal reactors.

J.L. Rempe; K.Y. Suh; F. B. Cheung; S. B. Kim

2008-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Vocal Timing in the Bat  

E-Print Network (OSTI)

Bats are social organisms that live in large colonies. However, reliance upon echolocation in order to hunt and navigate, means that bats also face pressing acoustic challenges due to overlap with surrounding noise. Bats also possess fine control over the properties of their echolocation pulses. This study's goal was to determine how bats are able to effectively function in large groups despite the interfering noise generated by conspecifics. Mexican free-tailed bats (Tadarida brasiliensis) were exposed to both artificially generated interfering noises and noise generated by conspecifics, and the temporal characteristics of their resulting echolocation calls were analyzed. In addition, bats were given injections of dopaminergic and serotonergic drugs, in an effort to determine which monoamine(s) were capable of altering vocal motor timing and to determine which regions of the brain play a role in regulating the timing of echolocation. I hypothesized that bats would alter the timing of emission of their own echolocation pulses in response to noise, and that drugs affecting the 5HT2A receptor would shift the timing of emission of echolocation pulses. The first part of this dissertation describes a novel temporal alteration behavior that occurs in response to artificially generated intermittent noise, and is characterized by a period of pulse suppression followed by a gradual return to normal call rates. Bats alter the timing of emission of their echolocation pulses to avoid overlap with noise and call within silent periods. The second part of this study investigated whether dopamine or serotonin, or both, could alter the timing of this vocal behavior. The results of this study were inconclusive, although I found some evidence that 5HT2A agonists can produce faster responses. Finally, I show that echolocating bats suppress pulse emission in nearby conspecifics. The resulting decrease in call rate leads to an overall increase in information throughput. This study also demonstrates that bats respond to continuous noise by increasing their call rate, and that the switch between the responses to intermittent noise and continuous noise occurs at a duty cycle of 50% or higher. Overall, this dissertation establishes that bats alter the timing of emission of their echolocation calls in response to noise, and that these mechanisms may be regulated by serotoninergic mechanisms.

Jarvis, Jenna N

2013-05-01T23:59:59.000Z

122

Foliar retention of 15N tracers: implications for net canopy exchange in low- and high-elevation forest ecosystems  

Science Conference Proceedings (OSTI)

Nitrogen-15 ({sup 15}N) labelled ammonium and nitrate were applied to understory saplings in a low-elevation deciduous forest and a high-elevation coniferous forest during the 1993 growing season to estimate the minimum retention of inorganic N from wet deposition. Tissue samples were collected at both sites before and after the tracer applications to determine the initial and the final {sup 15}N content. The fraction of the tracer application retained by deciduous leaves or by current-year leaves and stems on conifers was calculated from measurements of {sup 15}N and total N content. At both study sites, tracer applications significantly increased the {sup 15}N content of sapling tissues, although there was no significant difference between the fractional retention of ammonium and nitrate. The results support earlier studies indicating that the foliar retention of {sup 15}N applied in simulated wet deposition is small. Our estimates of annual N uptake from wet deposition by the forest canopy at the low- and high-elevation study sites were only 14 and 7%, respectively. This study, along with prior studies of the different chemical forms of N deposition, indicates that canopy uptake of dry N deposition is a major contributor to the net canopy exchange of N in both forests.

Garten Jr, Charles T [ORNL; Schwab, Alison [ORNL; Shirshac, Terri [ORNL

1998-04-01T23:59:59.000Z

123

In-Vessel Retention Technology Development and Use for Advanced PWR Designs in the USA and Korea  

SciTech Connect

In-Vessel Retention (IVR) of molten core debris by means of external reactor vessel flooding is a cornerstone of severe accident management for Westinghouse's AP600 (advanced passive light water reactor) design. The case for its effectiveness (made in previous work by the PI) has been thoroughly documented, reviewed as part of the licensing certification, and accepted by the US Nuclear Regulatory Commission. A successful IVR would terminate a severe accident, passively, with the core in a stable, coolable configuration (within the lower head), thus avoiding the largely uncertain accident evolution with the molten debris on the containment floor. This passive plant design has been upgraded by Westinghouse to the AP1000, a 1000 MWe plant very similar to the AP600. The severe accident management approach is very similar too, including In-Vessel Retention as the cornerstone feature, and initial evaluations indicated that this would be feasible at the higher power as well. A similar strategy is adopted in Korea for the APR1400 plant. The overall goal of this project is to provide experimental data and develop the necessary basic understanding so as to allow the robust extension of the AP600 In-Vessel Retention strategy for severe accident management to higher power reactors, and in particular, to the AP1000 advanced passive design.

T.G. Theofanous; S.J. Oh; J.H. Scobel

2004-05-18T23:59:59.000Z

124

Comparison of the U-233 dog data of Stevens et al. with uranium retention functions in ICRP Publication 30 and a 3-compartment mammillary model for uranium  

SciTech Connect

Stevens measured the distribution, retention, and excretion of U-233 in seven beagles each given a single injection of U-233 citrate (2.8 ..mu..Ci/kg U-233 (VI) (approx.3 mg/dog)). These data, when plotted together with results obtained with the ICRP (Pub. 30) retention functions for purposes of comparison, are seen to differ only slightly from the ICRP-30 model. The number of transformations in the body, over a fifty-year period agree within a factor of 2. A three-compartment mammillary model has been parameterized from the data of Stevens by the method of Bernard. Retention in tissues of the body is represented by a linear combination of three compartments. The data plots for the dogs and ICRP-30 model will be presented and discussed together with the three compartment mammillary model for U-233 retention, distribution, and excretion. 3 figs., 2 tabs.

Bernard S.R.

1983-01-01T23:59:59.000Z

125

Building Retrofits: Energy Conservation and Employee Retention Considerations in Medium-Size Commercial Buildings  

E-Print Network (OSTI)

Commercial buildings are among the largest consumers of energy. In an attempt to control and reduce operating expenses, building owners and organizations leasing commercial space are pursuing energy efficiency measures to generate a higher return on investment. In this study, an extensive literature review is used to identify and discuss energy efficiency considerations for medium-size building owners and how savings from these measures may benefit organizations through employee satisfaction and retention. For the purpose of this study, the specific topics related to commercial building energy efficiency that were investigated include (1) outcomes of building retrofits (2) corporate social responsibility and performance; (3) performance of energy efficient buildings; (4) employee commitment, satisfaction productivity and organizational profitability; (5) green companies and employee attraction; (6) the cost of turnover. There is little literature specifically focused on the impact that energy efficient buildings have on medium-sized building owners and no literature that quantifies the financial benefits through a reduction in employee turnover or attrition. Facility managers of all building sizes will benefit from gaining (1) a broad understanding of the impact of energy efficiency measures on employees (2) the ability to articulate the impact of the building’s role on employee productivity, turnover and other HR related issues (3) the insight needed to contribute to strategic discussions within their organization about how facilities can benefit organizational profitability. This research does not attempt to claim or determine a causal relationship between energy efficiency and employee turnover however it does discuss issues that that could affect employee attrition.. Further research to determine this causality would benefit the study of energy efficiency and its total impact on organizations.

Freeman, Janice

2013-05-01T23:59:59.000Z

126

Joint production and economic retention quantity decisions in capacitated production systems serving multiple market segments  

E-Print Network (OSTI)

In this research, we consider production/inventory management decisions of a rmthat sells its product in two market segments during a nite planning horizon. In thebeginning of each period, the rm makes a decision on how much to produce basedon the production capacity and the current on-hand inventory available. After theproduction is made at the beginning of the period, the rm rst satises the stochasticdemand from customers in its primary market. Any primary market demand thatcannot be satised is lost. After satisfying the demand from the primary market, ifthere is still inventory on hand, all or part of the remaining products can be sold ina secondary market with ample demand at a lower price. Hence, the second decisionthat the rm makes in each period is how much to sell in the secondary market, orequivalently, how much inventory to carry to the next period.The objective is to maximize the expected net revenue during a nite planninghorizon by determining the optimal production quantity in each period, and theoptimal inventory amount to carry to the next period after the sales in primary andsecondary markets. We term the optimal inventory amount to be carried to the nextperiod as \\economic retention quantity". We model this problem as a nite horizonstochastic dynamic program. Our focus is to characterize the structure of the optimalpolicy and to analyze the system under dierent parameter settings. Conditioning on given parameter set, we establish lower and upper bounds on the optimal policyparameters. Furthermore, we provide computational tools to determine the optimalpolicy parameters. Results of the numerical analysis are used to provide furtherinsights into the problem from a managerial perspective.

Katariya, Abhilasha Prakash

2008-08-01T23:59:59.000Z

127

An Enhanced In-Vessel Core Catcher for Improving In-Vessel Retention Margins  

SciTech Connect

In-vessel retention (IVR) of core melt that may relocate to the lower head of a reactor vessel is a key severe accident management strategy adopted by some operating nuclear power plants and proposed for several advanced light water reactors. A U.S.-Korean International Nuclear Energy Research Initiative project has been initiated to explore design enhancements that could increase the margin for IVR for advanced reactors with higher power levels [up to 1500 MW(electric)]. As part of this effort, an enhanced in-vessel core catcher is being designed and evaluated. To reduce cost and simplify manufacture and installation, this new core catcher design consists of several interlocking sections that are machined to fit together when inserted into the lower head. If needed, the core catcher can be manufactured with holes to accommodate lower head penetrations. Each section of the core catcher consists of two material layers with an option to add a third layer (if deemed necessary). The first is a base material that has the capability to support and contain the mass of core materials that may relocate during a severe accident; the second is an oxide coating on top of the base material, which resists interactions with high-temperature core materials; and the third is an optional coating on the bottom side of the base material to protect it from oxidation during the lifetime of the reactor. This paper summarizes results from the invessel core catcher design and evaluation efforts, focusing on recently obtained results from materials interaction tests and prototypic testing activities.

Joy L. Rempe

2005-11-01T23:59:59.000Z

128

Development of an Enhanced Core Catcher for Improving In-Vessel Retention Margins  

Science Conference Proceedings (OSTI)

In-vessel retention (IVR) of core melt that may relocate to the lower head of a reactor vessel is a key severe accident management strategy adopted by some operating nuclear power plants and proposed for several advanced light water reactors. A U.S.-Korean International Nuclear Energy Research Initiative project has been initiated to explore design enhancements that could increase the margin for IVR for advanced reactors with higher power levels [up to 1500 MW(electric)]. As part of this effort, an enhanced in-vessel core catcher is being designed and evaluated. To reduce cost and simplify manufacture and installation, this new core catcher design consists of several interlocking sections that are machined to fit together when inserted into the lower head. If needed, the core catcher can be manufactured with holes to accommodate lower head penetrations. Each section of the core catcher consists of two material layers with an option to add a third layer (if deemed necessary). The first is a base material that has the capability to support and contain the mass of core materials that may relocate during a severe accident; the second is an oxide coating on top of the base material, which resists interactions with high-temperature core materials; and the third is an optional coating on the bottom side of the base material to protect it from oxidation during the lifetime of the reactor. This paper summarizes results from the in-vessel core catcher design and evaluation efforts, focusing on recently obtained results from materials interaction tests and prototypic testing activities.

Rempe, J.L. [Idaho National Engineering and Environmental Laboratory (United States); Condie, K.G. [Idaho National Engineering and Environmental Laboratory (United States); Knudson, D.L. [Idaho National Engineering and Environmental Laboratory (United States); Suh, K.Y. [Seoul National University (Korea, Republic of); Cheung, F.B. [The Pennsylvania State University (United States); Kim, S.B. [Korea Atomic Energy Research Institute (Korea, Republic of)

2005-11-15T23:59:59.000Z

129

Time and Frequency Portal  

Science Conference Proceedings (OSTI)

NIST Home > Time and Frequency Portal. Time and Frequency Portal. Programs and Projects. CODATA values of the fundamental constants ...

2013-06-27T23:59:59.000Z

130

Time Series and Forecasting  

Science Conference Proceedings (OSTI)

Time Series and Forecasting. Leigh, Stefan and Perlman, S. (1991). "An Index for Comovement of Time Sequences With ...

131

NIST Forensics Science -- Drugs and Toxicology  

Science Conference Proceedings (OSTI)

... Sign up to receive news about NIST Forensic Science. *Email Address. ... NIST Forensic Science — Drugs and Toxicology. Credit: iStock. ...

2013-09-23T23:59:59.000Z

132

Prevalence of Drug-Resistant Tuberculosis in Mainland China: Systematic Review and Meta-Analysis  

E-Print Network (OSTI)

Background: The spread of drug-resistant tuberculosis (TB) is one of the major public health problems in the world. Surveillance of anti-TB drug resistance is important for monitoring TB control strategies. However, the status of drugresistant TB in China has been reported inconsistently. Methods: We systematically reviewed published studies on drug-resistant TB in China until March 31, 2011, and quantitatively summarized prevalence and patterns of anti-TB drug resistance among new cases and previously treated cases, respectively. Results: Ninety-five eligible articles, published during 1993–2011, were included in this review. The meta-analyses showed that the prevalence of drug-resistant TB in new cases was 27.9 % (95 % CI, 25.6%–30.2%) (n/N = 27360/104356) and in previously treated cases was 60.3 % (95 % CI, 56.2%–64.2%) (n/N = 30350/45858). Furthermore, in these two study populations, the prevalence of multiple drug resistance was found to be 5.3 % (95 % CI, 4.4%–6.4%) (n/N = 8810/101718) and 27.4 % (95 % CI, 24.1%–30.9%) (n/N = 10486/44530) respectively. However, the results were found to be frequently heterogeneous (p for Q tests,0.001). The most common resistance was observed for isoniazid among both study populations. Different patterns of drug resistance were observed in the subgroup analysis with respect to geographic areas, drug susceptibility testing methods and subject enrollment time.

Yu Yang; Xiangwei Li; Feng Zhou; Qi Jin; Lei Gao

2011-01-01T23:59:59.000Z

133

Time Resolved Deposition Measurements in NSTX  

SciTech Connect

Time-resolved measurements of deposition in current tokamaks are crucial to gain a predictive understanding of deposition with a view to mitigating tritium retention and deposition on diagnostic mirrors expected in next-step devices. Two quartz crystal microbalances have been installed on NSTX at a location 0.77m outside the last closed flux surface. This configuration mimics a typical diagnostic window or mirror. The deposits were analyzed ex-situ and found to be dominantly carbon, oxygen, and deuterium. A rear facing quartz crystal recorded deposition of lower sticking probability molecules at 10% of the rate of the front facing one. Time resolved measurements over a 4-week period with 497 discharges, recorded 29.2 {micro}g/cm{sup 2} of deposition, however surprisingly, 15.9 {micro}g/cm{sup 2} of material loss occurred at 7 discharges. The net deposited mass of 13.3 {micro}g/cm{sup 2} matched the mass of 13.5 {micro}g/cm{sup 2} measured independently by ion beam analysis. Monte Carlo modeling suggests that transient processes are likely to dominate the deposition.

C.H. Skinner; H. Kugel; A.L. Roquemore; J. Hogan; W.R. Wampler; the NSTX team

2004-08-03T23:59:59.000Z

134

In-Vessel Retention of Molten Core Debris in the Westinghouse AP1000 Advanced Passive PWR  

SciTech Connect

In-vessel retention (IVR) of molten core debris via external reactor vessel cooling is the hallmark of the severe accident management strategies in the AP600 passive PWR. The vessel is submerged in water to cool its external surface via nucleate boiling heat transfer. An engineered flow path through the reactor vessel insulation provides cooling water to the vessel surface and vents steam to promote IVR. For the 600 MWe passive plant, the predicted heat load from molten debris to the lower head wall has a large margin to the critical heat flux on the external surface of the vessel, which is the upper limit of the cooling capability. Up-rating the power of the passive plant from 600 to 1000 MWe (AP1000) significantly increases the heat loading from the molten debris to the reactor vessel lower head in the postulated bounding severe accident sequence. To maintain a large margin to the coolability limit for the AP1000, design features and severe accident management (SAM) strategies to increase the critical heat flux on the external surface of the vessel wall need to be implemented. A test program at the ULPU facility at University of California Santa Barbara (UCSB) has been initiated to investigate design features and SAM strategies that can enhance the critical heat flux. Results from ULPU Configuration IV demonstrate that with small changes to the ex-vessel design and SAM strategies, the peak critical heat flux in the AP1000 can be increased at least 30% over the peak critical heat flux predicted for the AP600 configuration. The design and SAM strategy changes investigated in ULPU Configuration IV can be implemented in the AP1000 design and will allow the passive plant to maintain the margin to critical heat flux for IVR, even at the higher power level. Continued testing for IVR phenomena is being performed at UCSB to optimize the AP1000 design and to ensure that vessel failure in a severe accident is physically unreasonable. (authors)

Scobel, James H.; Conway, L.E. [Westinghouse Electric Company LLC, P.O. Box 355, Pittsburgh, PA 15230-0355 (United States); Theofanous, T.G. [Center for Risk Studies and Safety, University of California Santa Barbara (United States)

2002-07-01T23:59:59.000Z

135

Mar. Drugs 2013, 11, 3350-3371; doi:10.3390/md11093350 marine drugs  

E-Print Network (OSTI)

Mar. Drugs 2013, 11, 3350-3371; doi:10.3390/md11093350 marine drugs ISSN 1660-3397 www% cytotoxicity was observed at the highest concentration tested (5 µg mL-1 ). However, OPEN ACCESS #12;Mar. Drugs Pinna had first been implicated in food poisoning in China in 1990 [1]. Pinnatoxin A (Pn

Recanati, Catherine

136

Grain Retention and Formation of Planetesimals near the Snow Line in MRI-driven Turbulent Protoplanetary Disks  

E-Print Network (OSTI)

The first challenge in the formation of both terrestrial planets and the cores of gas giants is the retention of grains in protoplanetary disks. In most regions of these disks, gas attains sub-Keplerian speeds as a consequence of a negative pressure gradient. Hydrodynamic drag leads to orbital decay and depletion of the solid material in the disk, with characteristic timescales as short as only a few hundred years for meter-sized objects at 1 AU. In this paper, we suggest a particle retention mechanism which promotes the accumulation of grains and the formation of planetesimals near the water sublimation front or ``snow line.'' This model is based on the assumption that, in the regions most interesting for planet formation, the viscous evolution of the disk is due to turbulence driven by the magneto-rotational instability (MRI) in the surface layers of the disk. The depth to which MRI effectively generates turbulence is a strong function of the grain size and abundance. A sharp increase in the grain-to-gas density ratio across the snow line reduces the column depth of the active layer. As the disk evolves towards a quasi-steady-state, this change in the active layer creates a local maximum in radial distribution of the gas surface density and pressure, causing the gas to rotate at super-Keplerian speed and halting the inward migration of grains. This senario presents a robust process for grain retention which may aid in the formation of proto-gas-giant cores preferentially near the snow line.

Katherine A. Kretke; D. N. C. Lin

2007-06-08T23:59:59.000Z

137

Chemical Innovation in Drug Dr Matthew Fuchter  

E-Print Network (OSTI)

Chemical Innovation in Drug Discovery Dr Matthew Fuchter Lecturer in Synthetic and Medicinal&D Spending and Output #12;Chemical Innovation Impact Discovery Development Basic research: years 0-3 Pre 3, File DRUG Chemical start point Hit to lead Preclinical Assessment Synthetic Chemistry Chemistry

138

Results of Large-Scale Testing on Effects of Anti-Foam Agent on Gas Retention and Release  

Science Conference Proceedings (OSTI)

The U.S. Department of Energy (DOE) Office of River Protection’s Waste Treatment Plant (WTP) will process and treat radioactive waste that is stored in tanks at the Hanford Site. The waste treatment process in the pretreatment facility will mix both Newtonian and non-Newtonian slurries in large process tanks. Process vessels mixing non-Newtonian slurries will use pulse jet mixers (PJMs), air sparging, and recirculation pumps. An anti-foam agent (AFA) will be added to the process streams to prevent surface foaming, but may also increase gas holdup and retention within the slurry. The work described in this report addresses gas retention and release in simulants with AFA through testing and analytical studies. Gas holdup and release tests were conducted in a 1/4-scale replica of the lag storage vessel operated in the Pacific Northwest National Laboratory (PNNL) Applied Process Engineering Laboratory using a kaolin/bentonite clay and AZ-101 HLW chemical simulant with non-Newtonian rheological properties representative of actual waste slurries. Additional tests were performed in a small-scale mixing vessel in the PNNL Physical Sciences Building using liquids and slurries representing major components of typical WTP waste streams. Analytical studies were directed at discovering how the effect of AFA might depend on gas composition and predicting the effect of AFA on gas retention and release in the full-scale plant, including the effects of mass transfer to the sparge air. The work at PNNL was part of a larger program that included tests conducted at Savannah River National Laboratory (SRNL) that is being reported separately. SRNL conducted gas holdup tests in a small-scale mixing vessel using the AZ-101 high-level waste (HLW) chemical simulant to investigate the effects of different AFAs, their components, and of adding noble metals. Full-scale, single-sparger mass transfer tests were also conducted at SRNL in water and AZ-101 HLW simulant to provide data for PNNL’s WTP gas retention and release modeling.

Stewart, Charles W.; Guzman-Leong, Consuelo E.; Arm, Stuart T.; Butcher, Mark G.; Golovich, Elizabeth C.; Jagoda, Lynette K.; Park, Walter R.; Slaugh, Ryan W.; Su, Yin-Fong; Wend, Christopher F.; Mahoney, Lenna A.; Alzheimer, James M.; Bailey, Jeffrey A.; Cooley, Scott K.; Hurley, David E.; Johnson, Christian D.; Reid, Larry D.; Smith, Harry D.; Wells, Beric E.; Yokuda, Satoru T.

2008-01-03T23:59:59.000Z

139

Estimated Maximum Gas Retention from Uniformly Dispersed Bubbles in K Basin Sludge Stored in Large-Diameter Containers  

DOE Green Energy (OSTI)

This letter report addresses the KE Basin sludge that will be retrieved and stored in large-diameter containers (LDCs.) A fraction of the hydrogen gas bubbles generated from the corrosion of uranium metal and oxides may be retained within the sludge matrix. Those entrapped bubbles will expand the sludge bed volume and, therefore, will affect how much sludge can be loaded into a container. The entrapped gas bubbles will also impact the overall thermal conductivity and heat capacity of the sludge bed. The evaluation summarized here was performed to estimate the maximum gas holdup (volume fraction gas) that could occur sludge stored in large-diameter containers, assuming uniform gas generation (i.e., uniform distribution of metallic uranium particles). This report represents an evaluation of the retention of uniformly distributed bubbles and an estimate of the maximum gas fraction that might be retained in K Basin LDCs based on existing literature data on bubble retention and Basin sludge characterization data. Existing data show that the maximum gas fraction varies, depending on physical properties and the configuration of the material or waste.

Gauglitz, Phillip A.; Terrones, Guillermo

2002-05-15T23:59:59.000Z

140

Compiling for time predictability  

Science Conference Proceedings (OSTI)

Within the T-CREST project we work on hardware/software architectures and code-generation strategies for time-predictable embedded and cyber-physical systems. In this paper we present the single-path code generation approach that we plan to explore and ... Keywords: compilers, real-time systems, time predictability, worst-case execution-time analysis

Peter Puschner; Raimund Kirner; Benedikt Huber; Daniel Prokesch

2012-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Certifying execution time  

Science Conference Proceedings (OSTI)

In this paper we present the framework Abstraction-Carrying CodE Platform for Timing validation (ACCEPT), designed for timing analysis of embedded real-time systems using the worst-case execution time (WCET) as the safety parameter. In the context ...

Vítor Rodrigues; João Pedro Pedroso; Mário Florido; Simão Melo de Sousa

2011-05-01T23:59:59.000Z

142

Sensitive radioenzymatic assay for catechol drugs  

Science Conference Proceedings (OSTI)

This assay measures picogram quantities of catechol drugs and endogenous catecholamines in body tissues and fluids. The catechols are converted to their 3H-O-methyl metabolites during incubation with 3H-S-adenosylmethionine then separated by solvent extraction and thin-layer chromatography. Most drugs containing the catechol structure can be radiolabeled and separated from norepinephrine and epinephrine by this technique to provide simultaneous measurement of endogenous and exogenously administered catechols. The disposition of isoproterenol in tissues and fluids of man and experimental animals is measured to illustrate the utility of this assay. The reactivity of several commonly administered catechol drugs with COMT is described and the possible implications discussed.

Durrett, L.R.; Ziegler, M.G.

1980-01-01T23:59:59.000Z

143

An analysis of retention issues of scientists, engineers, and program managers in the US Air Force  

E-Print Network (OSTI)

The United States Air Force is having a difficult time retaining their technical officers, who are critical to the success of their research, development, and acquisitions of major military and defense systems. A statistical ...

Beck, Derek William, 1977-

2005-01-01T23:59:59.000Z

144

An Analytic Approach To Estimating The Required Surplus, Benchmark Profit, And Optimum Reinsurance Retention For An Insurance Enterprise Using Moments Of The Severity Distribution And Key Frequency Distribution Values.  

E-Print Network (OSTI)

?? This paper presents an analysis of the capital needs, needed return on capital, and optimum reinsurance retention for insurance companies, all in the context… (more)

Boor, Joseph Allen

2012-01-01T23:59:59.000Z

145

An implantable device for localized drug delivery and sensing  

E-Print Network (OSTI)

There are many potential clinical applications for localized drug delivery and sensing systems, such as cancer, vaccinations, pain management, and hormone therapy. Localized drug delivery systems reduce the amount of drug ...

Daniel, Karen D

2009-01-01T23:59:59.000Z

146

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network (OSTI)

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

147

TECHNETIUM RETENTION IN WTP LAW GLASS WITH RECYCLE FLOW-SHEET DM10 MELTER TESTING VSL-12R2640-1 REV 0  

SciTech Connect

Melter tests were conducted to determine the retention of technetium and other volatiles in glass while processing simulated Low Activity Waste (LAW) streams through a DM10 melter equipped with a prototypical off-gas system that concentrates and recycles fluid effiuents back to the melter feed. To support these tests, an existing DM10 system installed at Vitreous State Laboratory (VSL) was modified to add the required recycle loop. Based on the Hanford Tank Waste Treatment and Immobilization Plant (WTP) LAW off-gas system design, suitably scaled versions of the Submerged Bed Scrubber (SBS), Wet Electrostatic Precipitator (WESP), and TLP vacuum evaporator were designed, built, and installed into the DM10 system. Process modeling was used to support this design effort and to ensure that issues associated with the short half life of the {sup 99m}Tc radioisotope that was used in this work were properly addressed and that the system would be capable of meeting the test objectives. In particular, this required that the overall time constant for the system was sufficiently short that a reasonable approach to steady state could be achieved before the {sup 99m}Tc activity dropped below the analytical limits of detection. The conceptual design, detailed design, flow sheet development, process model development, Piping and Instrumentation Diagram (P&ID) development, control system design, software design and development, system fabrication, installation, procedure development, operator training, and Test Plan development for the new system were all conducted during this project. The new system was commissioned and subjected to a series of shake-down tests before embarking on the planned test program. Various system performance issues that arose during testing were addressed through a series of modifications in order to improve the performance and reliability of the system. The resulting system provided a robust and reliable platform to address the test objectives.

Abramowitz, Howard [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Brandys, Marek [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Cecil, Richard [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; D'Angelo, Nicholas [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Matlack, Keith S. [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Muller, Isabelle S. [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Pegg, Ian L. [Energy Solutions, Federal EPC, Inc., Columbia, MD (United States); Callow, Richard A. [Energy Solutions, Federal EPC, Inc., Columbia, MD (United States); Joseph, Innocent

2012-12-11T23:59:59.000Z

148

Intradermal needle-free powdered drug injection  

E-Print Network (OSTI)

This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

Liu, John (John Hsiao-Yung)

2012-01-01T23:59:59.000Z

149

The globalization of clinical drug development  

E-Print Network (OSTI)

Industry-sponsored clinical research of investigational drugs (also called clinical development) has traditionally been carried out in relatively developed countries in the North American, Western European, and Pacific ...

Thiers, Fabio Albuquerque

2006-01-01T23:59:59.000Z

150

Essays on Drug Use and Crime  

E-Print Network (OSTI)

initiation to drugs and crime in Britain. Economic Journal,to avoid being convicted of a crime that is in the strikethe courts, prisons, and crime in California and Washington

Deza, Monica

2012-01-01T23:59:59.000Z

151

Computational model of local intravascular drug delivery  

E-Print Network (OSTI)

Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

Balakrishnan, Brinda

2007-01-01T23:59:59.000Z

152

Animal Reactions to Chemicals/Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

in dogs. Other drugs like Tylenol, while safe in humans can also be toxic in dogs and cats. Even vegetables like onions can be toxic to cats and dogs. Many other examples exist,...

153

Echogenic Lipsomes for targeted drug delivery  

Science Conference Proceedings (OSTI)

Echogenic immunoliposomes (ELIP) are under development to enable ultrasound-controlled drug delivery. Mechanistic studies in vitro have revealed that stable cavitation is correlated with enhanced recombinant tissue Plasminogen Activator (rt-PA) thrombolysis, ...

Christy K. Holland; David D. McPherson

2009-06-01T23:59:59.000Z

154

Time-Resolved  

NLE Websites -- All DOE Office Websites (Extended Search)

Time-Resolved Time-Resolved Time-Resolved Print Of the four fundamental parameters that we use to perceive the physical world (energy, momentum, position, and time) three correspond to the three broad categories of synchrotron experimental measurement techniques: spectroscopy (energy), scattering (momentum), and imaging (position). The fourth parameter-time-can in principle be applied to all the techniques. At the ALS, many experiments can be carried out in real time, with data being recorded from the same sample as it changes over time. Some time-resolved experiments take advantage of the pulsed nature of the ALS's synchrotron radiation, which, like a strobe light, can capture a series of "snapshots" of a process that, when viewed sequentially, show us how a given process evolves over time. Other experiments simply require two pulses: one to "pump" energy into the sample system and a second to probe the system's excited state.

155

Monitoring gas retention and slurry transport during the transfer of waste from Tank 241-C-106 to Tank 241-AY-102  

SciTech Connect

The retained gas volume can be estimated by several methods. All of these methods have significant uncertainties, but together they form a preponderance of evidence that describes the gas retention behavior of the tank. The methods are (1) an increase in nonconvective layer thickness; (2) a waste surface level rise (surface level effect [SLE] model); (3) the barometric pressure effect (BPE model); (4) direct void measurement; and (5) the consequences of the transfer process. The nonconvective layer thickness can be determined with sufficient accuracy to describe the overall waste configuration by means of temperature profiles or densitometer indications. However, the presence of a nonconvective layer does not necessarily indicate significant gas retention, and small changes in layer thickness that could quantify gas retention cannot be detected reliably with the methods available. The primary value of this measurement is in establishing the actual {open_quotes}fluffing factor{close_quotes} for thermal calculations. Surface level rise is not a useful measure of gas retention in Tank 241-C-106 (C-106) since the waste level fluctuates with regular makeup water additions. In Tank 241-AY-102 (AY-102) with the existing ventilation system it should be possible to determine the gas retention rate within 30-60% uncertainty from the surface level rise, should a significant rise be observed. The planned ventilation system upgrades in AY- 102 will greatly reduce the exhaust flow and the headspace humidity, and the evaporation rate should be significantly lower when transfers begin. This could reduce the uncertainty in gas retention rate estimates to around {+-} 10%.

Stewart, C.W.; Erian, F.F.; Meyer, P.A. [and others

1997-07-01T23:59:59.000Z

156

In Utero Drug Exposure Detection by Meconium Analysis  

Science Conference Proceedings (OSTI)

... 5-MeO-DiPT Pharmacokinetics Meyer & Maurer Current Drug Metabolism 2010 ... Jang, PhD China Brazil Brazil ... Emerging Trends in Designer Drugs

2013-04-30T23:59:59.000Z

157

Enhancement of the predicted drug hepatotoxicity in gel entrapped hepatocytes within polysulfone-g-poly (ethylene glycol) modified hollow fiber  

Science Conference Proceedings (OSTI)

Collagen gel-based 3D cultures of hepatocytes have been proposed for evaluation of drug hepatotoxicity because of their more reliability than traditional monolayer culture. The collagen gel entrapment of hepatocytes in hollow fibers has been proven to well reflect the drug hepatotoxicity in vivo but was limited by adsorption of hydrophobic drugs onto hollow fibers. This study aimed to investigate the impact of hollow fibers on hepatocyte performance and drug hepatotoxicity. Polysulfone-g-poly (ethylene glycol) (PSf-g-PEG) hollow fiber was fabricated and applied for the first time to suppress the drug adsorption. Then, the impact of hollow fibers was evaluated by detecting the hepatotoxicity of eight selected drugs to gel entrapped hepatocytes within PSf and PSf-g-PEG hollow fibers, or without hollow fibers. The hepatocytes in PSf-g-PEG hollow fiber showed the highest sensitivity to drug hepatotoxicity, while those in PSf hollow fiber and cylindrical gel without hollow fiber underestimated the hepatotoxicity due to either drug adsorption or low hepatic functions. Therefore, the 3D culture of gel entrapped hepatocytes within PSf-g-PEG hollow fiber would be a promising tool for investigation of drug hepatotoxicity in vitro.

Shen Chong [Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou, Zhejiang 310027 (China); Zhang Guoliang [Institute of Biological and Environmental Engineering, Zhejiang University of Technology, Zhejiang 310012 (China); Meng Qin, E-mail: mengq@zju.edu.c [Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou, Zhejiang 310027 (China)

2010-12-01T23:59:59.000Z

158

DOE/EA-1444: Environmental Assessment for the Construction of New Office Building, Child-Care Facility, Parking Garage, And Storm Water Retention Pond (September 2002)  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

4 4 ENVIRONMENTAL ASSESSMENT For the Construction of New Office Building, Child-Care Facility, Parking Garage, And Storm Water Retention Pond United States Department of Energy National Energy Technology Laboratory September 2002 DOE/EA-1444 ENVIRONMENTAL ASSESSMENT For the Construction of New Office Building, Child-Care Facility, Parking Garage, And Storm Water Retention Pond United States Department of Energy National Energy Technology Laboratory September 2002 National Environmental Policy Act (NEPA) Compliance Cover Sheet Proposed Action: The U.S. Department of Energy (DOE) proposes to upgrade facilities and infrastructure at the National Energy Technology Laboratory (NETL), Morgantown, WV, through acquisition of a 5-acre

159

Mechanisms of gas bubble retention and release: results for Hanford Waste Tanks 241-S-102 and 241-SY-103 and single-shell tank simulants  

DOE Green Energy (OSTI)

Research at Pacific Northwest National Laboratory (PNNL) has probed the physical mechanisms and waste properties that contribute to the retention and release of flammable gases from radioactive waste stored in underground tanks at Hanford. This study was conducted for Westinghouse Hanford Company as part of the PNNL Flammable Gas Project. The wastes contained in the tanks are mixes of radioactive and chemical products, and some of these wastes are known to generate mixtures of flammable gases, including hydrogen, nitrous oxide, and ammonia. Because these gases are flammable, their retention and episodic release pose a number of safety concerns.

Gauglitz, P.A.; Rassat, S.D.; Bredt, P.R.; Konynenbelt, J.H.; Tingey, S.M.; Mendoza, D.P.

1996-09-01T23:59:59.000Z

160

Regulation of expression of two Ly-6 family genes by intron retention and transcription induced chimerism.  

E-Print Network (OSTI)

in increasing proteome complexity, [1-3]. In relation to this, alterations of splic- ing patterns or mis-splicing of genes are involved in sev- eral pathologies, [4-6] including several genetic diseases such as spinal muscular atrophy (SMA), myotonic dystro- phy... and for LY6G5B were PR_1 and PR_5. Real-time RT-PCR for LY6G5B was performed by using SYBR® green PCR master mix and the ABI PRISM® 7700 sequence detection system (Applied Biosystems). Primers for real-time RT-PCR were designed for the differential...

Calvanese, Vincenzo; Mallya, Meera; Campbell, R Duncan; Aguado, Begona

2008-09-25T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Science Teaching in Texas: Investigating Relationships among Texas High School Science Teachers' Working Conditions, Job Satisfaction, and Retention  

E-Print Network (OSTI)

In many critical subject areas our schools are facing a need for teachers, particularly in the "high-need" areas of mathematics, science, and bilingual education. Educators and researchers alike have identified teacher turnover as a major contributor to the challenge of finding and keeping highly-qualified teachers in American classrooms. The purpose of the three studies in this dissertation was to investigate the potential role of working conditions in explaining the turnover rates of high school science teachers. I used data collected by the Policy Research Initiative in Science Education (PRISE) Research Group during the 2007-2008 and 2008-2009 academic years, from their random, stratified sample of 50 Texas high schools and their 385 science teachers. The first study focuses on the development of a rubric assessing individual science teachers' working conditions, which involved the examination of multiple data sources, including school master schedules and AEIS reports to determine the working conditions of 385 science teachers. Analyses from this study suggested that (a) science teachers from small schools experience tougher working conditions than science teachers from both medium and large schools; (b) veteran science teachers experience tougher working conditions than both induction and mid-career teachers; and (c) science teachers from lower minority schools experience tougher working conditions than science teachers from schools with higher MSEPs. The second study focuses on the relationship between high school science teachers? working conditions and their levels of job satisfaction. Findings included that (1) science teachers from small schools experienced tougher working conditions, even though they were more satisfied with their jobs; (2) veteran science teachers experienced tougher working conditions and were more satisfied with their jobs; and (3) science teachers from lower minority schools experienced tougher working conditions and were more satisfied with their jobs. The final study focuses on the relationship between high school science teachers' school size, MSEP, teacher type, working condition scores, job satisfaction scores, and retention status. Results of independent samples T-test revealed no significant difference in working condition scores for "stayers" versus "non-stayers." Pearson's correlation revealed school size and the experience level of the science teacher as significant predictors of working condition and job satisfaction scores. Results of the discriminant analysis revealed (a) working condition scores and job satisfaction scores as not significantly predicting science teacher retention; and (b) teacher type (beginning, mid-career, and veteran) as the only significant predictor of teacher retention.

Hollas, Victoria

2011-12-01T23:59:59.000Z

162

Retention of plutonium in mouse tissues as affected by antiviral compounds and their analogs  

SciTech Connect

The chelating agent DTPA (diethylenetriaminepentaacetic acid) is an effective therapeutic substance for decorporation of extracellar monomeric plutonium in the mouse and dog, but is much less effective in removing intracellular polymeric plutonium (Pu-P). In the absence of effective therapy, this intracellular plutonium is long retained in the body, particularly in reticuloendothelial tissues like the liver. Our interest, therefore, turned to the development of adjunct substances capable of removing additional plutonium from the liver beyond that removable by DTPA alone. We showed that glucan, a yeast cell wall polysaccharide, is a useful adjunct to DTPA for removal of Pu-P from the mouse liver. Its toxicity, however, makes it a less than desirable drug for potential human use. Therefore, we initiated a search for more soluble (and presumably less hazardous) therapeutic agents similar to glucan, i.e., capable of adjunct action with DTPA. Of over 20 substances tested the most successful results were obtained with two antiviral, antitumor compounds, the pyran copolymers XA-124-177 and XA-146-85-2. These are condensation products of divinyl ether and maleic anhydride. Another analog, EMH-227, prepared by condensation of acrylic acid and itaconic acid, was similarly successful. Maximal removal of plutonium from mouse liver was obtained with a single intravenous (I.V.) injection of 10 to 90 mg/kg of pyran copolymer given 5 days after I.V. Pu-P administration. Although these doses increased splenic uptake of plutonium, a dose of 10 mg/kg produced a minimal increase in the splenic burden while producing maximal removal of hepatic plutonium. (auth)

Lindenbaum, A.; Rosenthal, M.W.; Guilmette, R.A.

1975-01-01T23:59:59.000Z

163

Managing time, part 2  

Science Conference Proceedings (OSTI)

Masterful time management means not just tracking of messages in your personal environment, but managing your coordination network with others.

Peter J. Denning; Ritu Raj

2011-09-01T23:59:59.000Z

164

FREQUENCY AND TIME  

Science Conference Proceedings (OSTI)

... STRATWARM observed and FLARES expected ... observed and PROTON FLARE expected (- - ) STRATWARM ... time of observed solar or geophysical ...

2003-01-30T23:59:59.000Z

165

QuickTime VR  

Science Conference Proceedings (OSTI)

QuickTime VR. Christine Piatko and Sandy Ressler. ... Sandy Ressler's Office. Plant Floor of Black & Decker in Fayetteville NC. ...

166

Timed Property Sequence Chart  

Science Conference Proceedings (OSTI)

Property Sequence Chart (PSC) is a novel scenario-based notation, which has been recently proposed to represent temporal properties of concurrent systems. This language balances expressive power and simplicity of use. However, the current version of ... Keywords: Property Sequence Chart, Real-time specification patterns, Timed Property Sequence Chart, Timing properties

Pengcheng Zhang; Bixin Li; Lars Grunske

2010-03-01T23:59:59.000Z

167

Noncommutative Two Time Physics  

E-Print Network (OSTI)

We present a classical formalism describing two-time physics with Abelian canonical gauge field backgrounds. The formalism can be used as a starting point for the construction of an interacting quantized two-time physics theory in a noncommutative soace-time.

W. Chagas-Filho

2006-04-03T23:59:59.000Z

168

Final Report - Gas Retention and Release Tests Supporting the Concentrate Receipt Vessel (CRV-VSL-00002A/2B) Configuration  

DOE Green Energy (OSTI)

Gas Retention and Release (GR and R) tests were performed in the scaled Concentrate Receipt Vessel (CRV) Test Stand at the Savannah River National Laboratory to validate the capability of candidate Hybrid-Mixing systems for the CRV to safely release hydrogen during normal and upset conditions. Hydrogen is generated in the radioactive waste as a result of natural and plant processes and must not be allowed to accumulate above flammability limits. Two types of tests were conducted. Gas holdup tests determined the steady state amount of gas accumulated in the simulant under normal PJM only or PJM plus sparging conditions. Gas release tests determined what operating conditions are necessary to fully release gas after a steady state gas fraction of 4 per cent tank volume or more was reached in the simulant.

GUERRERO, HECTOR

2004-09-01T23:59:59.000Z

169

Quantum Operation Time Reversal  

E-Print Network (OSTI)

The dynamics of an open quantum system can be described by a quantum operation, a linear, complete positive map of operators. Here, I exhibit a compact expression for the time reversal of a quantum operation, which is closely analogous to the time reversal of a classical Markov transition matrix. Since open quantum dynamics are stochastic, and not, in general, deterministic, the time reversal is not, in general, an inversion of the dynamics. Rather, the system relaxes towards equilibrium in both the forward and reverse time directions. The probability of a quantum trajectory and the conjugate, time reversed trajectory are related by the heat exchanged with the environment.

Crooks, Gavin E

2007-01-01T23:59:59.000Z

170

Quantum Operation Time Reversal  

E-Print Network (OSTI)

The dynamics of an open quantum system can be described by a quantum operation, a linear, complete positive map of operators. Here, I exhibit a compact expression for the time reversal of a quantum operation, which is closely analogous to the time reversal of a classical Markov transition matrix. Since open quantum dynamics are stochastic, and not, in general, deterministic, the time reversal is not, in general, an inversion of the dynamics. Rather, the system relaxes towards equilibrium in both the forward and reverse time directions. The probability of a quantum trajectory and the conjugate, time reversed trajectory are related by the heat exchanged with the environment.

Gavin E. Crooks

2007-06-26T23:59:59.000Z

171

Secretary Bodman's Memorandum Regarding Drug Testing at DOE  

Energy.gov (U.S. Department of Energy (DOE))

Decisions regarding drug testing for Department of Energy positions that require access authorizations (Security Clearances)

172

Peer Mentor Program Application The purpose of the Peer Mentor Program is to increase retention of Asian/Pacific American students at  

E-Print Network (OSTI)

Peer Mentor Program Application The purpose of the Peer Mentor Program is to increase retention involvement and engagement with campus programs and resources. The commitment required of the Peer Mentors standing (by the beginning of Fall 2012) Demonstrate leadership through campus involvement or selected work

173

On the Time Times Temperature Bound  

E-Print Network (OSTI)

Recently Hod proposes a lower bound on the relaxation time of a perturbed thermodynamic system. For gravitational systems this bound transforms into a condition on the fundamental quasinormal frequency. We test the bound in some spacetimes whose quasinormal frequencies are calculated exactly, as the three-dimensional BTZ black hole, the D-dimensional de Sitter spacetime, and the D-dimensional Nariai spacetime. We find that for some of these spacetimes their fundamental quasinormal frequencies do not satisfy the bound proposed by Hod.

A. Lopez-Ortega

2010-06-28T23:59:59.000Z

174

What Time is It?  

Science Conference Proceedings (OSTI)

... These are sometimes marketed as "atomic clocks", but ... problems include incorrectly setting your local time zone on the clock, batteries that need ...

2011-01-19T23:59:59.000Z

175

Drug Testing for New Clearance Holders  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Drug Testing Prerequisite for DOE Security Clearance Applicants Drug Testing Prerequisite for DOE Security Clearance Applicants The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Current Status Clearance Action Test Required? Uncleared - Applicant Grant (Q/L, T/S/C) Yes Previously Cleared DOE-now uncleared DOE Reinstate (Q/L, T/S/C) Yes* Coming from another Federal agency, regardless of clearance status Grant (Q/L, T/S/C) Yes**

176

Drug Testing for New Clearance Holders  

NLE Websites -- All DOE Office Websites (Extended Search)

Drug Testing Prerequisite for DOE Security Clearance Applicants Drug Testing Prerequisite for DOE Security Clearance Applicants The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Current Status Clearance Action Test Required? Uncleared - Applicant Grant (Q/L, T/S/C) Yes Previously Cleared DOE-now uncleared DOE Reinstate (Q/L, T/S/C) Yes* Coming from another Federal agency, regardless of clearance status Grant (Q/L, T/S/C) Yes**

177

Above- and below-ground Litter Manipulation: Effect on Retention and Release of DOC, DON and DIN in the Sikfokut Forest, Hungary  

E-Print Network (OSTI)

The above- and below-ground litter from fallen foliage and root exudates and their decomposition has an impact on forest soil. The objective of this research project was to determine the effect of above- and below-ground litter manipulation on the retention and release of dissolved organic carbon (DOC), dissolved organic nitrogen (DON), nitrate and ammonium in the soil profile at 0-5 and 5-15 cm depths. The soils were obtained from a Long Term Ecological Research site in the Sikfokut Forest in Hungary. The site is a mature oak forest and the soil has no organic layer; the leaf litter sits directly on the A horizon. There are six treatments applied to the soil: doubling of annual leaf litter (DL), doubling of annual wood litter (DW), removal of annual leaf litter (NL), removal of roots (NR), removal of leaf and roots (NI) and control (C). Each plot is 7 x 7 m, and each soil sample taken was 15 x 15 cm square. A stock solution of leaf litter was added in different concentrations to soils from each treatment in a 50 mL centrifuge tube. Because I was investigating retention or release of carbon and nitrogen, I inverted the tube gently over a period of 2 hours prior to centrifugation and removal of supernatant. The supernatant solution was analyzed for DOC, DON, ammonium and nitrate to determine retention and release values for each dependant upon the different treatments. The results of the study were interesting. Dissolved organic nitrogen was neither retained nor released in the 0-5 cm layer for any treatment yet nitrate, typically considered a mobile anion showed retention and release in this layer. In the 5-15 cm layer we had no retention or release of nitrate but dissolved organic nitrogen was retained and released between the solid and solution phases.

Evetts, Elizabeth A.; Peterson, Jacqueline A.

2009-09-30T23:59:59.000Z

178

TIME CALIBRATED OSCILLOSCOPE SWEEP  

DOE Patents (OSTI)

The time calibrator of an electric signal displayed on an oscilloscope is described. In contrast to the conventional technique of using time-calibrated divisions on the face of the oscilloscope, this invention provides means for directly superimposing equal time spaced markers upon a signal displayed upon an oscilloscope. More explicitly, the present invention includes generally a generator for developing a linear saw-tooth voltage and a circuit for combining a high-frequency sinusoidal voltage of a suitable amplitude and frequency with the saw-tooth voltage to produce a resultant sweep deflection voltage having a wave shape which is substantially linear with respect to time between equal time spaced incremental plateau regions occurring once each cycle of the sinusoidal voltage. The foregoing sweep voltage when applied to the horizontal deflection plates in combination with a signal to be observed applied to the vertical deflection plates of a cathode ray oscilloscope produces an image on the viewing screen which is essentially a display of the signal to be observed with respect to time. Intensified spots, or certain other conspicuous indications corresponding to the equal time spaced plateau regions of said sweep voltage, appear superimposed upon said displayed signal, which indications are therefore suitable for direct time calibration purposes.

Owren, H.M.; Johnson, B.M.; Smith, V.L.

1958-04-22T23:59:59.000Z

179

Semantics, experience and time  

Science Conference Proceedings (OSTI)

The computational hypothesis, with its inherent representationalism, and the dynamical hypothesis, with its apparent absence of representations and its commitment to continuous time, stand at an impasse. It is unclear how the dynamical stance can handle ... Keywords: Computation, Experience, Invariance, Semantics, Situatedness, Time

Stephen E. Robbins

2002-09-01T23:59:59.000Z

180

Real-time shading  

Science Conference Proceedings (OSTI)

Real-time procedural shading was once seen as a distant dream. When the first version of this course was offered four years ago, real-time shading was possible, but only with one-of-a-kind hardware or by combining the effects of tens to hundreds of rendering ...

Marc Olano; Kurt Akeley; John C. Hart; Wolfgang Heidrich; Michael McCool; Jason L. Mitchell; Randi Rost

2004-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

TIMING OF SHOCK WAVES  

DOE Patents (OSTI)

This patent relates to means for ascertaining the instant of arrival of a shock wave in an exploslve charge and apparatus utilizing this means to coordinate the timing of two operations involving a short lnterval of time. A pair of spaced electrodes are inserted along the line of an explosive train with a voltage applied there-across which is insufficient to cause discharge. When it is desired to initiate operation of a device at the time the explosive shock wave reaches a particular point on the explosive line, the device having an inherent time delay, the electrodes are located ahead of the point such that the ionization of the area between the electrodes caused by the traveling explosive shock wave sends a signal to initiate operation of the device to cause it to operate at the proper time. The operated device may be photographic equipment consisting of an x-ray illuminating tube.

Tuck, J.L.

1955-03-01T23:59:59.000Z

182

Charge Retention by Gold Clusters on Surfaces Prepared Using Soft Landing of Mass Selected Ions  

Science Conference Proceedings (OSTI)

Monodisperse gold clusters have been prepared on surfaces in different charge states through soft landing of mass-selected ions. Ligand-stabilized gold clusters were prepared in methanol solution by reduction of chloro(triphenylphosphine)gold(I) with borane tert-butylamine complex in the presence of 1,3-bis(diphenylphosphino)propane. Electrospray ionization was used to introduce the clusters into the gas-phase and mass-selection was employed to isolate a single ionic cluster species (Au11L53+, L = 1,3-bis(diphenylphosphino)propane) which was delivered to surfaces at well controlled kinetic energies. Using in-situ time of flight secondary ion mass spectrometry (TOF-SIMS) it is demonstrated that the Au11L53+ cluster retains its 3+ charge state when soft landed onto the surface of a 1H,1H,2H,2H-

Johnson, Grant E.; Priest, Thomas A.; Laskin, Julia

2012-01-24T23:59:59.000Z

183

Digital time delay  

DOE Patents (OSTI)

Method and apparatus are provided for generating an output pulse following a trigger pulse at a time delay interval preset with a resolution which is high relative to a low resolution available from supplied clock pulses. A first lumped constant delay provides a first output signal at predetermined interpolation intervals corresponding to the desired high resolution time interval. Latching circuits latch the high resolution data to form a first synchronizing data set. A selected time interval has been preset to internal counters and corrected for circuit propagation delay times having the same order of magnitude as the desired high resolution. Internal system clock pulses count down the counters to generate an internal pulse delayed by an internal which is functionally related to the preset time interval. A second LCD corrects the internal signal with the high resolution time delay. A second internal pulse is then applied to a third LCD to generate a second set of synchronizing data which is complementary with the first set of synchronizing data for presentation to logic circuits. The logic circuits further delay the internal output signal with the internal pulses. The final delayed output signal thereafter enables the output pulse generator to produce the desired output pulse at the preset time delay interval following input of the trigger pulse.

Martin, A.D.

1986-05-09T23:59:59.000Z

184

Controlled drug release from bifunctionalized mesoporous silica  

Science Conference Proceedings (OSTI)

Serial of trimethylsilyl-carboxyl bifunctionalized SBA-15 (TMS/COOH/SBA-15) have been studied as carriers for controlled release of drug famotidine (Famo). To load Famo with large capacity, SBA-15 with high content of carboxyl groups was successfully synthesized by one-pot synthesis under the assistance of KCl. The mesostructure of carboxyl functionalized SBA-15 (COOH/SBA-15) could still be kept even though the content of carboxyl groups was up to 57.2%. Increasing carboxyl content could effectively enhance the loading capacity of Famo. Compared with pure SBA-15, into which Famo could be hardly adsorbed, the largest drug loading capacity of COOH/SBA-15 could achieve 396.9 mg/g. The release of Famo from mesoporous silica was studied in simulated intestine fluid (SIF, pH=7.4). For COOH/SBA-15, the release rate of Famo decreased with narrowing pore size. After grafting TMS groups on the surface of COOH/SBA-15 with hexamethyldisilazane, the release of Famo was greatly delayed with the increasing content of TMS groups. - Graphical abstract: Trimethylsilyl-carboxyl bifunctionalized SBA-15 has been studied as carrier for controlled release of drug famotidine. To load drug with large capacity, SBA-15 with high content of carboxyl groups was successfully synthesized. After grafting trimethylsilyl groups on the surface of carboxyl functionalized SBA-15, the release of Famo was greatly delayed with the increasing content of TMS groups.

Xu Wujun; Gao Qiang [State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001 (China); Graduate University of the Chinese Academy of Sciences, Beijing 100049 (China); Xu Yao [State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001 (China)], E-mail: xuyao@sxicc.ac.cn; Wu Dong; Sun Yuhan [State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001 (China); Shen Wanling [State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 (China); Graduate University of the Chinese Academy of Sciences, Beijing 100049 (China); Deng Feng [State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 (China)

2008-10-15T23:59:59.000Z

185

Environment Induced Time Arrow  

E-Print Network (OSTI)

The spread of the time arrows from the environment to an observed subsystem is followed within a harmonic model. A similarity is pointed out between irreversibility and a phase with spontaneously broken symmetry. The causal structure of interaction might be lost in the irreversible case, as well. The Closed Time Path formalism is developed for classical systems and shown to handle the time arrow problem in a clear and flexible manner. The quantum case is considered, as well, and the common origin of irreversibility and decoherence is pointed out.

Janos Polonyi

2012-06-25T23:59:59.000Z

186

VARIABLE TIME DELAY MEANS  

DOE Patents (OSTI)

An electrically variable time delay line is described which may be readily controlled simuitaneously with variable impedance matching means coupied thereto such that reflections are prevented. Broadly, the delay line includes a signal winding about a magnetic core whose permeability is electrically variable. Inasmuch as the inductance of the line varies directly with the permeability, the time delay and characteristic impedance of the line both vary as the square root of the permeability. Consequently, impedance matching means may be varied similariy and simultaneously w:th the electrically variable permeability to match the line impedance over the entire range of time delay whereby reflections are prevented.

Clemensen, R.E.

1959-11-01T23:59:59.000Z

187

Time, energy & form  

E-Print Network (OSTI)

Physical manifestations of time occur in natural forms of all sizes. Architectural form serves as shelter while providing a built envelope of human life, simultaneously influencing and influenced by energetic activities ...

McInnis, Martha Jane

1982-01-01T23:59:59.000Z

188

Dogs and Time  

NLE Websites -- All DOE Office Websites (Extended Search)

Question: I travel often and worry how leaving for long periods of time (and boarding my dog) will affect her. I wouldn't think that dogs could understand the concept of...

189

Wood Use Across Time  

E-Print Network (OSTI)

?Forest products history and use ?Forest resource- the big picture ?Consumption- the big picture ?Trends forest products industry ? pulp & paper ? solid woodBack in Time ?1492 ? Columbus sailed the ocean blue! ? wood use- fuelwood American Indians ?1634: Jean Nicolet

Scott Bowe; United States Wood Use

2005-01-01T23:59:59.000Z

190

Technical Talks Timing  

NLE Websites -- All DOE Office Websites (Extended Search)

Talks Timing The technical talks should last a maximum of 15 minutes with 5 minutes for set-up and 5 minutes for Q&A. No teamgroup presentations are allowed. The objective of...

191

Dissolved Nutrient Retention Dynamics in River Networks: A Modeling Investigation of Transient Flow and Scale Effects  

Science Conference Proceedings (OSTI)

In this paper, we use a dynamic network flow model, coupled with a transient storage zone biogeochemical model, to simulate dissolved nutrient removal processes at the channel network scale. We have explored several scenarios in respect of the combination of rainfall variability, and the biological and geomorphic characteristics of the catchment, to understand the dominant controls on removal and delivery of dissolved nutrients (e.g., nitrate). These model-based theoretical analyses suggested that while nutrient removal efficiency is lower during flood events compared to during baseflow periods, flood events contribute significantly to bulk nutrient removal, whereas bulk removal during baseflow periods is less. This is due to the fact that nutrient supply is larger during flood events; this trend is even stronger in large rivers. However, the efficiency of removal during both periods decreases in larger rivers, however, due to (i) increasing flow velocities and thus decreasing residence time, and (ii) increasing flow depth, and thus decreasing nutrient uptake rates. Besides nutrient removal processes can be divided into two parts: in the main channel and in the hyporheic transient storage zone. When assessing their relative contributions the size of the transient storage zone is a dominant control, followed by uptake rates in the main channel and in the transient storage zone. Increasing size of the transient storage zone with downstream distance affects the relative contributions to nutrient removal of the water column and the transient storage zone, which also impacts the way nutrient removal rates scale with increasing size of rivers. Intra-annual hydrologic variability has a significant impact on removal rates at all scales: the more variable the streamflow is, compared to mean discharge, the less nutrient is removed in the channel network. A scale-independent first order uptake coefficient, ke, estimated from model simulations, is highly dependent on the relative size of the transient storage zone and how it changes in the downstream direction, as well as the nature of hydrologic variability.

Ye, Sheng; Covino, Timothy P.; Sivapalan, Murugesu; Basu, Nandita; Li, Hongyi; Wang, Shaowen

2012-06-30T23:59:59.000Z

192

The Role of an Elementary School Principal in the Retention of Novice Teachers: A Micropolitical Case Study  

E-Print Network (OSTI)

Teachers are leaving the education profession at alarming rates and the attrition of teachers has become a serious issue for many schools and districts around the country. The purpose of this study was to investigate the retention and attrition patterns in one elementary school through the lens of micropolitical theory; in particular, principal decision-making processes, leadership activities, and the relationship between principal and teachers were studied. This qualitative, single case exploration included classroom observations, document analysis, and focus group and individual interviews with one principal, seven novice teachers, and one lead mentor. The data was analyzed using categorical aggregation and a constant comparative analysis. Study findings provided evidence that a negative micropolitical state was present at the school under study, including an absence of shared values and goals, lack of positive interpersonal relations, and lack of collegiality, all of which served to discourage the growth of novice teachers as developing professionals. Teacher perceptions revealed that they were less than satisfied with their chosen profession, particularly lacking contentment with the principal leadership.

Greninger, Elizabeth Ann

2012-05-01T23:59:59.000Z

193

Improving the efficiency of the later stages of the drug development process : survey results from the industry, academia, and the FDA  

E-Print Network (OSTI)

Drug development in the United States is a lengthy and expensive endeavor. It is estimated that average development times range from eleven to fifteen years and exceed costs of one billion dollars. The development pathway ...

Gottschalk, Adrian Hedley Benjamin, 1975-

2004-01-01T23:59:59.000Z

194

Quantum tunneling time  

E-Print Network (OSTI)

A simple model of a quantum clock is applied to the old and controversial problem of how long a particle takes to tunnel through a quantum barrier. The model I employ has the advantage of yielding sensible results for energy eigenstates, and does not require the use of time-dependant wave packets. Although the treatment does not forbid superluminal tunneling velocities, there is no implication of faster-than-light signaling because only the transit duration is measurable, not the absolute time of transit. A comparison is given with the weak-measurement post-selection calculations of Steinberg.

P. C. W. Davies

2004-03-01T23:59:59.000Z

195

NSIT Computer Time Services: Internet Time Service (ITS) ...  

Science Conference Proceedings (OSTI)

Page 1. NIST Special Publication 250-59 NIST Computer Time Services: Internet Time Service (ITS), Automated Computer Time Service (ACTS), ...

2012-09-16T23:59:59.000Z

196

Luminal flow amplifies stent-based drug deposition in arterial  

E-Print Network (OSTI)

Background: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely ...

Levine, Evan G.

197

High throughput optical sensor arrays for drug screening  

E-Print Network (OSTI)

In the world of drug discovery, high throughput whole cell assays are a critical step in discovering therapeutically relevant drug compounds [1]. This report details the development of several novel sensor systems capable ...

Harjes, Daniel I

2006-01-01T23:59:59.000Z

198

Amphiphilic linear-dendritic block copolymers for drug delivery  

E-Print Network (OSTI)

Polymeric drug delivery systems have been widely used in the pharmaceutical industry. Such systems can solubilize and sequester hydrophobic drugs from degradation, thereby increasing circulation half-life and efficacy. ...

Nguyen, Phuong, Ph. D. Massachusetts Institute of Technology

2007-01-01T23:59:59.000Z

199

Research Sheds Light on Workings of Anti-cancer Drug  

NLE Websites -- All DOE Office Websites (Extended Search)

Research Sheds Light on Workings of Anti-cancer Drug The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson...

200

Regression analysis of oncology drug licensing deal values  

E-Print Network (OSTI)

This work is an attempt to explain wide variations in drug licensing deal value by using regression modeling to describe and predict the relationship between oncology drug deal characteristics and their licensing deal ...

Hawkins, Paul Allen

2006-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Fact Sheet, Consequences of a Positive Drug Test - September...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Consequences of a Positive Drug Test - September 14, 2007 Fact Sheet, Consequences of a Positive Drug Test - September 14, 2007 September 14, 2007 Fact Sheet on the Consequences of...

202

Alignment strategies for drug product process development and manufacturing  

E-Print Network (OSTI)

The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the product-process interaction ...

Garvin, Christopher John

2012-01-01T23:59:59.000Z

203

Optically generated ultrasound for enhanced drug delivery  

DOE Patents (OSTI)

High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

2002-01-01T23:59:59.000Z

204

An identification of policies and practices that hinder and facilitate the admission and retention of Hispanics in institutions of higher education  

E-Print Network (OSTI)

The purpose of this study was to identify policies and practices that impact the admission and retention of Hispanics in higher education. The study did this by identifying those policies and practices that are currently being used and that facilitate or hinder institutions of higher education in the recruitment, admission, retention, and graduation of students, particularly Hispanic students. The researcher utilized the Delphi method to conduct the study. This research method produces a consensus of opinion from a group of individuals identified as experts in a given field. Three structured surveys were conducted. Each round of surveys had two questionnaires: (a) policies and practices that positively or negatively impact the admission of Hispanics in higher education and (b) policies and practices that positively or negatively impact the retention of Hispanics in higher education. Conclusions The Texas Academic Skills Program (TASP) is negatively affecting Hispanic studentsÂ? admission into Texas colleges and universities. Further, it is affecting the retention of Hispanic students in Texas institutions. If students do poorly on the TASP, they are placed in remedial courses. Even though students successfully complete all remediation courses (even with AÂ?s & BÂ?s), if they do not pass the TASP after remediation, they cannot continue college level work. This causes many students to become discouraged and leave college. Although college test makers, such as the Educational Testing Service (ETS), state that the SAT should be used as an assessment instrument, many Texas collegeÂ?s continue to use it for admissions and awarding scholarships; both of which are contrary to test-makersÂ? recommendations. College admission tests are hindering the admission of Hispanic students into colleges and universities. Tuition costs, particularly where students depend heavily on loans, are keeping students from entering college, from continuing in college, and from pursuing graduate and post-graduate degrees.

Cantu, Linda Valdez

2004-12-01T23:59:59.000Z

205

Probabilistic timed behavior trees  

Science Conference Proceedings (OSTI)

The Behavior Tree notation has been developed as a method for systematically and traceably capturing user requirements. In this paper we extend the notation with probabilistic behaviour, so that reliability, performance, and other dependability properties ... Keywords: behavior trees, model checking, probabilities, timed automata

Robert Colvin; Lars Grunske; Kirsten Winter

2007-07-01T23:59:59.000Z

206

Mechanisms of gas retention and release: Experimental results for Hanford single-shell waste tanks 241-A-101, 241-S-106, and 241-U-103  

Science Conference Proceedings (OSTI)

The 177 underground waste storage tanks at the Hanford Site contain millions of gallons of radioactive waste resulting from the purification of nuclear materials and related processes. Through various mechanisms, flammable gas mixtures of hydrogen, ammonia, methane, and nitrous oxide are generated and retained in significant quantities within the waste in many ({approximately}25) of these tanks. The potential for large releases of retained gas from these wastes creates a flammability hazard. It is a critical component of the effort to understand the flammability hazard and a primary goal of this laboratory investigation to establish an understanding of the mechanisms of gas retention and release in these wastes. The results of bubble retention experimental studies using waste samples from several waste tanks and a variety of waste types support resolution of the Flammable Gas Safety Issue. Gas bubble retention information gained in the pursuit of safe storage will, in turn, benefit future waste operations including salt-well pumping, waste transfers, and sluicing/retrieval.

Rassat, S.D.; Caley, S.M.; Bredt, P.R.; Gauglitz, P.A.; Rinehart, D.E.; Forbes, S.V.

1998-09-01T23:59:59.000Z

207

Genepool Time Heatmaps  

NLE Websites -- All DOE Office Websites (Extended Search)

Genepool Time Heatmaps Genepool Time Heatmaps Heatmap of Time and Slots Requested vs Time Waited (in hours) | Queue: All | Last 7 Days Time Requested Slots 1wk Job Count Longest Wait 1 23.0 (233) 0.37 (1819) 27.54 (49888) 5.85 (124593) 1.23 (39835) 0.34 (732) 0 0.4 (224) 0.02 (1) 217325 538.96 2 0 0.01 (19) 2.54 (78) 0.2 (140) 0.99 (2683) 0 0 0 0 2920 9.1 4 0.08 (1) 0 2.82 (141) 0.36 (143) 1.07 (12) 0.06 (5) 0.01 (5) 0.06 (1) 1.3 (5) 313 20.48 6 0.01 (2) 0 0.09 (32) 0.07 (1) 0 0 0 0 0 35 1.22 8 0.04 (24) 4.32 (7423) 5.31 (1999) 0.53 (316) 13.14 (2486) 0.01 (2) 1.21 (88) 1.3 (34) 8.33 (68) 12440 46.16 10 0 0 0 0 0 0 0 8.56 (1) 0 1 8.56 16 0 0 0 0.03 (1) 0 0 0 0 0 1 0.03 24 0 0 0 0 0 0 0 0 0.01 (1) 1 0.01 32 0 0 0 0.04 (14) 0 0 0 0.01 (6) 0 20 0.26

208

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network (OSTI)

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

209

Timed fast charger  

Science Conference Proceedings (OSTI)

In a charger for rechargeable electrochemical cells, a transformer charging circuit supplies a charging current to the battery at a fast charge rate for a predetermined time followed by a continuous slow charge rate. A normally closed automatic reset thermostat in series with the rectifier diodes in the charging circuit, and thermally coupled to them, opens after a period of time, dependent upon the heat generated by the rectifier diodes and upon the thermal mass of the thermostat and diodes, and terminates the fast charge current. A resistor, shunted across the thermostat and thermally coupled to it, establishes a slow charge rate current path when the thermostat opens. Heat generated in the resistor causes the thermostat to remain open as long as the battery is connected and ac power is supplied to the transformer primary winding.

Mullersman, F.H.

1981-10-27T23:59:59.000Z

210

Internet Topology over Time  

E-Print Network (OSTI)

There are few studies that look closely at how the topology of the Internet evolves over time; most focus on snapshots taken at a particular point in time. In this paper, we investigate the evolution of the topology of the Autonomous Systems graph of the Internet, examining how eight commonly-used topological measures change from January 2002 to January 2010. We find that the distributions of most of the measures remain unchanged, except for average path length and clustering coefficient. The average path length has slowly and steadily increased since 2005 and the average clustering coefficient has steadily declined. We hypothesize that these changes are due to changes in peering policies as the Internet evolves. We also investigate a surprising feature, namely that the maximum degree has changed little, an aspect that cannot be captured without modeling link deletion. Our results suggest that evaluating models of the Internet graph by comparing steady-state generated topologies to snapshots of the real data ...

Edwards, Benjamin; Stelle, George; Forrest, Stephanie

2012-01-01T23:59:59.000Z

211

Space Time Matter inflation  

E-Print Network (OSTI)

We study a model of power-law inflationary inflation using the Space-Time-Matter (STM) theory of gravity for a five dimensional (5D) canonical metric that describes an apparent vacuum. In this approach the expansion is governed by a single scalar (neutral) quantum field. In particular, we study the case where the power of expansion of the universe is $p \\gg 1$. This kind of model is more successful than others in accounting for galaxy formation.

Mariano Anabitarte; Mauricio Bellini

2005-08-31T23:59:59.000Z

212

QUADRENNIAL MCNP TIMING STUDY  

Science Conference Proceedings (OSTI)

The Los Alamos National Laboratory Monte Carlo N-Particle radiation transport code, MCNP, is widely used around the world for many radiation protection and shielding applications. As a well-known standard it is also an excellent vehicle for assessing the relative performance of scientific computing platforms. Every three-to-four years a new version of MCNP is released internationally by the Radiation Safety Information Computational Center (RSICC) in Oak Ridge, Tennessee. For each of the past few releases, we have also done a timing study to assess the progress of scientific computing platforms and software. These quadrennial timing studies are valuable to the radiation protection and shielding community because (a) they are performed by a recognized scientific team, not a computer vendor, (b) they use an internationally recognized code for radiation protection and shielding calculations, (c) they are eminently reproducible since the code and the test problems are internationally distributed. Further, if one has a computer platform, operating system, or compiler not presented in our results, its performance is directly comparable to the ones we report because it can use the same code, data, and test problems as we used. Our results, using a single processor per platform, indicate that hardware advances during the past three years have improved performance by less than a factor of two and software improvements have had a marginal effect on performance. The most significant impacts on performance have resulted from developments in multiprocessing and multitasking. The other most significant advance in the last three years has been the accelerated improvements in personal computers. In the last timing study, the tested personal computer was approximately a factor of four slower that the fastest machine tested, a DEC Alphastation 500. In the present study, the fastest PC tested was less than a factor of two slower than the fastest platform, which is a Compaq (previously DEC) Alpha XP1000.

E. C. SELCOW; B. D. LANSRUD

2000-09-01T23:59:59.000Z

213

Exploiting VERITAS Timing Information  

E-Print Network (OSTI)

The 499 pixel photomultiplier cameras of the VERITAS gamma ray telescopes are instrumented with 500MHz sampling Flash ADCs. This paper describes a preliminary investigation of the best methods by which to exploit this information so as to optimize the signal-to-noise ratio for the detection of Cherenkov light pulses. The FADCs also provide unprecedented resolution for the study of the timing characteristics of Cherenkov images of cosmic-ray and gamma-ray air showers. This capability is discussed, together with the implications for gamma-hadron separation.

J. Holder; for the VERITAS Collaboration

2005-07-19T23:59:59.000Z

214

Layered double hydroxides as supports for intercalation and sustained release of antihypertensive drugs  

SciTech Connect

Zn/Al layered double hydroxides (LDHs) were intercalated with the anionic antihypertensive drugs Enalpril, Lisinopril, Captopril and Ramipril by using coprecipitation or ion-exchange technique. TG-MS analyses suggested that the thermal stability of Ena{sup -}, Lis{sup -} (arranged with monolayer, resulted from X-ray diffraction (XRD) and Fourier transform infrared spectra (FT-IR) analysis was enhanced much more than Cap{sup -} and Ram{sup -} (arranged with bilayer). The release studies show that the release rate of all samples markedly decreased in both pH 4.25 and 7.45. However, the release time of Ena{sup -}, Lis{sup -} were much longer compared with Cap{sup -}, Ram{sup -} in both pH 4.25 and 7.45, it is possible that the intercalated guests, arranged with monolayer in the interlayer, show lesser repulsive force and strong affinity with the LDH layers. And the release data followed both the Higuchi-square-root law and the first-order equation well. Based on the analysis of batch release, intercalated structural models as well as the TG-DTA results, we conclude that for drug-LDH, stronger the affinity between intercalated anions and the layers is, better the thermal property and the stability to the acid attack of drug-LDH, and the intercalated anions are easier apt to monolayer arrangement within the interlayer, were presented. - Graphical abstract: A series of antihypertensive drugs including Enalpril, Lisinopril, Captopril and Ramipril were intercalated into Zn/Al-NO{sub 3}-LDHs successfully by coprecipitation or ion-exchange technique. We focus on the structure, thermal property and low/controlled release property of as-synthesized drug-LDH composite intended for the possibility of applying these LDH-antihypertensive nanohybrids in drug delivery and controlled release systems.

Xia Shengjie [College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032 (China); Ni Zheming [College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032 (China)], E-mail: jchx@zjut.edu.cn; Xu Qian; Hu Baoxiang; Hu Jun [College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032 (China)

2008-10-15T23:59:59.000Z

215

Attitudes and knowledge about naloxone and overdose prevention among detained drug users in Ningbo, China  

E-Print Network (OSTI)

deaths. According to the recent China Drug Control Law, drugin the way of China’s new Drug Control Law. Int J DrugLu L, Fang Y, Wang X: Drug Abuse in China: Past Present and

Liu, Yu; Bartlett, Nicholas; Li, Longhui; Lv, Xiuyi; Zhang, Yahai; Zhou, Wenhua

2012-01-01T23:59:59.000Z

216

Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery  

E-Print Network (OSTI)

Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to ...

Seto, Jennifer Elizabeth

2011-01-01T23:59:59.000Z

217

Good Timing: NIST/CU Collaboration Adds Timing Capability ...  

Science Conference Proceedings (OSTI)

... With the added capability to track the timing of dynamic biochemical reactions, cell ... to measure sensor signals at two points in time at a rate of up to ...

2012-02-07T23:59:59.000Z

218

A Time Bucket Formulation for the TSP with Time Windows  

E-Print Network (OSTI)

Nov 10, 2009 ... The Traveling Salesman Problem with Time Windows (TSPTW) is the problem of finding a ... To obtain a good partition of the time windows, we.

219

Clinical, Laboratorial, and Urodynamic Findings of Prostatic Artery Embolization for the Treatment of Urinary Retention Related to Benign Prostatic Hyperplasia. A Prospective Single-Center Pilot Study  

Science Conference Proceedings (OSTI)

PurposeThis study was designed to describe the clinical, laboratorial, and urodynamic findings of prostatic artery embolization (PAE) in patients with urinary retention due to benign prostatic hyperplasia (BPH).MethodsA prospective study of 11 patients with urinary retention due to BPH was conducted. Patients underwent physical examination, prostate specific antigen (PSA) measurement, transrectal ultrasound, and magnetic resonance imaging. International prostate symptom score (IPSS), quality of life (QoL), and urodynamic testing were used to assess the outcome before and after 1 year.ResultsClinical success was 91 % (10/11 patients) with a mean follow-up of 22.3 months (range, 12-41 months). At the first year follow-up, the mean IPSS score was 2.8 points (p = 0.04), mean QoL was 0.4 points (p = 0.001), mean PSA decreased from 10.1 to 4.3 ng/mL (p = 0.003), maximum urinary flow (Qmax) improved from 4.2 to 10.8 mL/sec (p = 0.009), and detrusor pressure (Pdet) decreased from 85.7 to 51.5 cm H{sub 2}O (p = 0.007). Before PAE, Bladder Outlet Obstruction Index (BOOI) showed values >40 in 100 % of patients. After PAE, 30 % of patients were >40 (obstructed), 40 % were between 20 and 40 (undetermined), and 30 % were <20 (unobstructed). Patients with a BOOI <20 had higher PSA values at 1-day after PAE.ConclusionsClinical and urodynamic parameters improved significantly after PAE in patients with acute urinary retention due to BPH. Total PSA at day 1 after PAE was higher in patients with unobstructed values in pressure flow studies.

Antunes, Alberto A. [University of Sao Paulo Medical School, Division of Urology (Brazil); Carnevale, Francisco C., E-mail: fcarnevale@uol.com.br; Motta Leal Filho, Joaquim M. da [University of Sao Paulo Medical School, Interventional Radiology Unit (Brazil); Yoshinaga, Eduardo M. [University of Sao Paulo Medical School, Division of Urology (Brazil); Cerri, Luciana M. O. [University of Sao Paulo Medical School, Ultrasound Unit (Brazil); Baroni, Ronaldo H. [University of Sao Paulo Medical School, Magnetic Resonance Unit (Brazil); Marcelino, Antonio S. Z. [University of Sao Paulo Medical School, Ultrasound Unit (Brazil); Cerri, Giovanni G. [University of Sao Paulo Medical School, Radiology Department (Brazil); Srougi, Miguel [University of Sao Paulo Medical School, Division of Urology (Brazil)

2013-08-01T23:59:59.000Z

220

The Heliosphere in Time  

E-Print Network (OSTI)

Because of the dynamic nature of the interstellar medium, the Sun should have encountered a variety of different interstellar environments in its lifetime. As the solar wind interacts with the surrounding interstellar medium to form a heliosphere, different heliosphere shapes, sizes, and particle contents result from the different environments. Some of the large possible interstellar parameter space (density, velocity, temperature) is explored here with the help of global heliosphere models, and the features in the resulting heliospheres are compared and discussed. The heliospheric size, expressed as distance of the nose of the heliopause to the Sun, is set by the solar wind - interstellar pressure balance, even for extreme cases. Other heliospheric boundary locations and neutral particle results correlate with the interstellar parameters as well. If the H0 clouds identified in the Millennium Arecibo survey are typical of clouds encountered by the Sun, then the Sun spends ~99.4% of the time in warm low density ISM, where the typical upwind heliosphere radii are up to two orders of magnitude larger than at present.

H. -R. Müller; P. C. Frisch; B. D. Fields; G. P. Zank

2008-10-02T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 September 1, 2011 The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Matrix, Drug Testing for DOE security clearance - September 1, 2011

222

DOE Laboratories Help Develop Promising New Cancer Fighting Drug,  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Laboratories Help Develop Promising New Cancer Fighting Drug, Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm Addthis Powerful X-Rays Enable Development of Successful Treatment for Melanoma and Other Life-Threatening Diseases WASHINGTON, DC - Powerful X-ray technology developed at the U.S. Department of Energy's (DOE's) national laboratories is revealing new insights into diseases ranging from Alzheimer's to the swine flu, and, most recently, enabled the discovery of a groundbreaking new drug treatment for malignant melanoma, the deadliest form of skin cancer. The drug, Zelboraf (vemurafenib), received Food and Drug Administration (FDA) approval on Wednesday. In showing the structures of diseased and

223

DOE Laboratories Help Develop Promising New Cancer Fighting Drug,  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Laboratories Help Develop Promising New Cancer Fighting Drug, Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm Addthis Powerful X-Rays Enable Development of Successful Treatment for Melanoma and Other Life-Threatening Diseases WASHINGTON, DC - Powerful X-ray technology developed at the U.S. Department of Energy's (DOE's) national laboratories is revealing new insights into diseases ranging from Alzheimer's to the swine flu, and, most recently, enabled the discovery of a groundbreaking new drug treatment for malignant melanoma, the deadliest form of skin cancer. The drug, Zelboraf (vemurafenib), received Food and Drug Administration (FDA) approval on Wednesday. In showing the structures of diseased and

224

Light Sources Help Discover New Drug Against Melanoma | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma July 18, 2011 - 12:07pm Addthis The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. Mike Ross Science Writer at SLAC National Accelerator Laboratory What does this mean for me? A new drug designed to fight melanoma was discovered thanks to the

225

NIST Time Scale Data Archive  

Science Conference Proceedings (OSTI)

NIST Time Scale Data Archive. ... The AT1 scale is run in real time using data from an ensemble of cesium standards and hydrogen masers. ...

2013-08-07T23:59:59.000Z

226

Time and Frequency Division Homepage  

Science Conference Proceedings (OSTI)

... Controlled ClocksTelephone TimeDivision HistoryFrequently Asked Questions (FAQ)Time and Frequency from A to Z: An illustrated glossaryA Walk ...

2013-12-27T23:59:59.000Z

227

Time dependent Directional Profit Model for Financial Time Series Forecasting  

E-Print Network (OSTI)

Time dependent Directional Profit Model for Financial Time Series Forecasting Jingtao YAO Chew Lim@comp.nus.edu.sg Abstract Goodness­of­fit is the most popular criterion for neural network time series forecasting. In the context of financial time series forecasting, we are not only concerned at how good the forecasts fit

Yao, JingTao

228

Ethics and Drug-Free Certification Form  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

NEW EMPLOYEE ORIENTATION NEW EMPLOYEE ORIENTATION ETHICS BRIEFING CERTIFICATION OF ______________________________ (Print Name) I hereby certify that I have reviewed the New Employee Orientation information on the Standards of Ethical Conduct for Employees in the Executive Branch, 5 C.F. R. Part 2635, and the DOE 3792.3 Drug-Free Federal Workplace Testing Program. Further, I certify that I understand that all Department of Energy employees, other than Special Government Employees, must obtain prior written approval from their immediate supervisor and an ethics counselor prior to engaging in outside activities, regardless of whether those activities are compensated. I understand that this requirement includes approval of any activities in which I am engaged upon entering Federal

229

Higher Prices from Entry: Pricing of Brand-Name Drugs  

E-Print Network (OSTI)

4 Bertrand and Cartel Prices Vary with z 7T, CS L Figure 5Distance Cumulative Abnormal Price Changes (%) Dissimilarof New Drug Figure 6 Cumulative Unexpected Price Effects

Perloff, Jeffrey M.; Suslow, Valerie Y.; Seguin, Paul J.

1995-01-01T23:59:59.000Z

230

Office of Departmental Personnel Security - Drug Testing for...  

NLE Websites -- All DOE Office Websites (Extended Search)

Departmental Personnel Security Home Mission and Functions PERSEC Corner Clearance Automation Departmental Personnel Security FAQs Drug Testing for DOE Positions FAQs...

231

Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs  

E-Print Network (OSTI)

Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

Wu, Peter I-Kung

2007-01-01T23:59:59.000Z

232

Unveiling the Molecular Structure of the Target of Many Drugs...  

NLE Websites -- All DOE Office Websites (Extended Search)

2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Unveiling the Molecular Structure of the Target of Many Drugs DECEMBER 3, 2007 Bookmark and Share Structure...

233

Drug Inventory Control : Case: Thai International Hospital Mahasarakham.  

E-Print Network (OSTI)

??This final thesis was conducted for Thai International Hospital Maharakham, a medium sized private hospital, located in the northeastern region of Thailand. Since drug expenditure… (more)

Theptong, Jutamas

2010-01-01T23:59:59.000Z

234

Evaluation of centrally acting drugs in mice with fighting behaviour ...  

Science Conference Proceedings (OSTI)

From the Department of Pharmacology, Medical Research Laboratories. Chas. Pfizer & Co., Groton, Conn., U.S.A.. Evaluation of Centrally Acting Drugs in Mice.

235

The (In)Security of Drug Testing - Vulnerability Assessment Team...  

NLE Websites -- All DOE Office Websites (Extended Search)

Selected Papers > The (In)Security of Drug Testing VAT Projects Introducing the VAT Adversarial Vulnerability Assessments Safety Tags & Product Counterfeiting Election Security...

236

Retention indices, relative response factors, and mass spectra of trifluoroethyl and heptafluorobutyl esters of carboxylic acids determined by capillary GC/MS  

SciTech Connect

The GC/MS characteristics of carboxylic acid esters prepared from fluorine-containing alcohols were compared to those of methyl esters. The GC retention of 2,2,2-trifluoroethyl (TFE) esters was less than, and 2,2,3,3,4,4,4-heptafluoro-1-butyl (HFB) esters approximately equivalent to that of methyl esters. The peak shape of both TFE and HFB esters was slightly superior to that of methyl esters. Mass spectra of TFE and HFB aliphatic esters show significantly more intense molecular and key fragment ions than those of methyl esters. Also, owing to their significantly higher molecular weights, TFE or HFB ester molecular ions and most fragment ions of interest occur at significantly higher m/z values than most potential interfering ions. The GC retention indices, relative GC/MS total ion current response factors, and 70 eV electron impact mass spectra of about 70 TFE and 70 HFB carboxylic acid esters are reported. Results from analysis of a TFE/HFB esterified petroleum carboxylic acid concentrate are discussed in detail. 26 refs., 17 figs., 3 tabs.

Yu, S.K.-T.; Vrana, R.P.; Green, J.B.

1990-11-01T23:59:59.000Z

237

Scaling Laws for Reduced-Scale Tests of Pulse Jet Mixing Systems in Non-Newtonian Slurries: Gas Retention and Release Behavior  

Science Conference Proceedings (OSTI)

The Waste Treatment Plant (WTP) under construction at the Hanford Site will use pulse jet mixer (PJM) technology for mixing and gas retention control applications in tanks expected to contain waste slurries exhibiting a non-Newtonian rheology. This paper presents the results of theoretical and experimental studies performed to establish the methodology to perform reduced-scale gas retention and release tests with PJM systems in non-Newtonian fluids with gas generation. The technical basis for scaled testing with unsteady jet mixing systems in gas-generating non-Newtonian fluids is presented in the form of a bubble migration model that accounts for the gas generation rate, the average bubble rise velocity, and the geometry of the vessel. Scaling laws developed from the model were validated with gas holdup and release tests conducted at three scales: large scale, 1/4 scale, and 1/9 scale. Experiments were conducted with two non-Newtonian simulants with in-situ gas generation by decomposition of hydrogen peroxide. The data were compared non-dimensionally, and the important scale laws were examined. From these results, scaling laws are developed which allow the design of mixing systems at a reduced scale.

Stewart, Charles W.; Meyer, Perry A.; Kurath, Dean E.; Barnes, Steven M.

2006-03-02T23:59:59.000Z

238

J. Plasma Fusion Res. SERIES, Vol. 10 (2013) Simulating Tritium Retention in Tungsten with a Multiple Trap Model in the TMAP Code a  

E-Print Network (OSTI)

Accurately predicting the quantity of tritium retained in plasma facing components is a key safety issue for licensing future fusion power reactors. Retention of tritium in the lattice damage caused when high energy neutrons collide with atoms in the structural material of the reactor’s plasma facing components (PFCs) is an area of ongoing experimental research at the Idaho National Laboratory (INL) under the US/Japan TITAN collaboration. Recent experiments with the Tritium Plasma Experiment (TPE), located in the INL’s Safety and Tritium Applied Research (STAR) facility, demonstrate that this damage can only be simulated by computer codes like the Tritium Migration Analysis Program (TMAP) if one assumes that the lattice damage produced by these neutrons results in multiple types of hydrogen traps (energy wells) within the material, each possessing a different trap energy and density. Previous attempts to simulate the quantity of deuterium released from neutron irradiated TPE tungsten targets indicated that at least six different traps are required by TMAP to model this release. In this paper we describe a recent extension of the TMAP trap site model to include as many traps as required by the user to simulate retention of tritium in neutron damaged tungsten. This model has been applied to data obtained for tungsten irradiated to a damage level of 0.025 dpa in the High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory (ORNL) after exposure to a plasma in TPE.

Brad J. Merrill; Masashi Shimada; Paul W. Humrickhouse

2012-01-01T23:59:59.000Z

239

Generation and Retention of Helium and Hydrogen in Austenitic Steels Irradiated in a Variety of LWR and Test Reactor Spectral Environments  

DOE Green Energy (OSTI)

In fission and fusion reactor environments stainless steels generate significant amounts of helium and hydrogen by transmutation. The primary sources of helium are boron and nickel, interacting with both fast and especially thermal neutrons. Hydrogen arises primarily from fast neutron reactions, but is also introduced into steels at often much higher levels by other environmental processes. Although essentially all of the helium is retained in the steel, it is commonly assumed that most of the hydrogen is not retained. It now appears that under some circumstances, significant levels of hydrogen can be retained, especially when helium-nucleated cavities become a significant part of the microstructure. A variety of stainless steel specimens have been examined from various test reactors, PWRs and BWRs. These specimens were exposed to a wide range of neutron spectra with different thermal/fast neutron ratios. Pure nickel and pure iron have also been examined. It is shown that all major features of the retention of helium and hydrogen can be explained in terms of the composition, thermal/fast neutron ratio and the presence or absence of helium-nucleated cavities. In some cases, the hydrogen retention is very large and can exceed that generated by transmutation, with the additional hydrogen arising from either environmental sources and/or previously unidentified radioisotope sources that may come into operation at high neutron exposures.

Garner, Francis A.; Oliver, Brian M.; Greenwood, Lawrence R.; Edwards, Danny J.; Bruemmer, Stephen M.; Grossbeck, Martin L.

2002-03-31T23:59:59.000Z

240

First-passage-time problems in time-aware networks  

E-Print Network (OSTI)

First passage time or the first time that a stochastic process crosses a boundary is a random variable whose probability distribution is sought in engineering, statistics, finance, and other disciplines. The probability ...

Suwansantisuk, Watcharapan, 1978-

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Molecular aptamers for drug delivery Weihong Tan1,2  

E-Print Network (OSTI)

University, Xiamen Fujian, 361005, China The active targeting of drugs in a cell-, tissue- or diseaseMolecular aptamers for drug delivery Weihong Tan1,2 , Hui Wang2 , Yan Chen1,2,3 , Xiaobing Zhang1, 410082, China 2 Center for Research at Bio/Nano Interface, Department of Chemistry, Department

Tan, Weihong

242

How molecular imaging is speeding up antiangiogenic drug development  

E-Print Network (OSTI)

How molecular imaging is speeding up antiangiogenic drug development Weibo Cai,1 Jianghong Rao,1 Sanjiv S. Gambhir,1,2 and Xiaoyuan Chen1 1 The Molecular Imaging Program at Stanford, Department. The shift in recent drug discovery to novel agents against specific molecular targets high- lights the need

Rao, Jianghong

243

NIST: A Walk Through Time - The "Atomic Age" of Time ...  

Science Conference Proceedings (OSTI)

... Transportation, communication, financial transactions, manufacturing, electric power and many ... The next generation of time standards is presently ...

2010-10-05T23:59:59.000Z

244

Feeling molecular forces: tactile feedback to enhance drug design  

E-Print Network (OSTI)

Molecular modeling is a vital component for structure-based drug design. Currently implemented technology combines data and graphics to give the user visual capabilities to assist in discovering possible binding arrangements. Visual modeling has become a tremendous help to scientists in reducing the amount of time needed to create new inhibitory compounds. However, the visual medium used for modeling lacks the ability to convey the forces between the molecules to the user. Potentially, tactile feedback can provide this missing information. SensAble Devices has developed a device capable of producing force feedback to a user-defined environment called the PHANToM, The PHANToM is a 6 dimensional (3 translational and 3 rotational) haptic device that can return force and torque to the user through a hand held stylus. The system configuration for molecular modeling consists of integrating the haptic device with a high-end PC running Windows NT and developing code to model the intermolecular forces. The programming language used was C with some C++ constructs and the OpenGL graphics library for the graphics implementation. The optimized code running with the system has proven capable of calculating and relaying tactile feedback between a 100-atom active site of a protein and a small 15-atom inhibitor in real time (ca. 1 millisecond). Trials are now underway on the system to evaluate accuracy and explore other forms of useful output. Once this is accomplished, modeling will be done on an active site and an untested inhibitor to evaluate novel binding modes.

Williams, Jocylin Amber

2000-01-01T23:59:59.000Z

245

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

246

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

247

NRC drug-free workplace plan. Revision 1  

SciTech Connect

On September 15, 1986, President Reagan signed Executive Order 12564, establishing the goal of a Drug-Free Federal Workplace. The Order made it a condition of employment that all Federal employees refrain from using illegal drugs on or off duty. On July 11, 1987, Congress passed legislation affecting implementation of the Executive Order under Section 503 of the Supplemental Appropriations Act of 1987, Public Law 100-71 (the Act). The Nuclear Regulatory Commission first issued the NRC Drug Testing Plan to set forth objectives, policies, procedures, and implementation guidelines to achieve a drug-free Federal workplace, consistent with the Executive Order and Section 503 of the Act. Revision 1, titled, ``NRC Drug-Free Workplace Plan,`` supersedes the previous version and its supplements and incorporates changes to reflect current guidance from the Department of Justice, the Department of Health and Human Services, as well as other guidance.

1997-11-01T23:59:59.000Z

248

NIST Time Scale Data Archive  

Science Conference Proceedings (OSTI)

NIST Time Scale Data Archive. Updated monthly. Return to Archive index Leap second and UT1-UTC information. This page ...

2013-08-07T23:59:59.000Z

249

Personalised time-dependent learning  

Science Conference Proceedings (OSTI)

Time-dependent instruction appears to shape next-generation learning systems, where the value of instruction is as important as the time it takes to learn. The ability to grasp the exact knowledge required to accomplish a specific task, in the ... Keywords: adaptive learning, authoring tools, knowledge management, learning granularity, learning objects, learning resources, learning technology, learning web, ontology, personalised learning, semantic web, time constraints, time-dependent learning, timeliness

R. Benlamri; Y. Atif; J. Berri

2009-04-01T23:59:59.000Z

250

Fabrication and testing analysis of tapered silicon microneedles for drug delivery applications  

Science Conference Proceedings (OSTI)

Drug delivery plays an important role in the treatment of disease, and the equipment used for drug delivery has a great impact on the delivery efficiency of drugs. Recently developed for drug delivery, the new microneedle apparatus has the potential ... Keywords: Chemical etching, Dicing saw, Drug delivery, Microneedles

Xiao-Xiao Yan, Jing-Quan Liu, Shui-Dong Jiang, Bin Yang, Chun-Sheng Yang

2013-11-01T23:59:59.000Z

251

Errors in determination of soil water content using time-domain reflectometry caused by soil compaction around wave guides  

Science Conference Proceedings (OSTI)

Application of time domain reflectometry (TDR) in soil hydrology often involves the conversion of TDR-measured dielectric permittivity to water content using universal calibration equations (empirical or physically based). Deviations of soil-specific calibrations from the universal calibrations have been noted and are usually attributed to peculiar composition of soil constituents, such as high content of clay and/or organic matter. Although it is recognized that soil disturbance by TDR waveguides may have impact on measurement errors, to our knowledge, there has not been any quantification of this effect. In this paper, we introduce a method that estimates this error by combining two models: one that describes soil compaction around cylindrical objects and another that translates change in bulk density to evolution of soil water retention characteristics. Our analysis indicates that the compaction pattern depends on the mechanical properties of the soil at the time of installation. The relative error in water content measurement depends on the compaction pattern as well as the water content and water retention properties of the soil. Illustrative calculations based on measured soil mechanical and hydrologic properties from the literature indicate that the measurement errors of using a standard three-prong TDR waveguide could be up to 10%. We also show that the error scales linearly with the ratio of rod radius to the interradius spacing.

Ghezzehei, T.A.

2008-05-29T23:59:59.000Z

252

Results of 1999 Spectral Gamma-Ray and Neutron Moisture Monitoring of Boreholes at Specific Retention Facilities in the 200 East Area, Hanford Site  

SciTech Connect

Twenty-eight wells and boreholes in the 200 East Are% Hanford Site, Washington were monitored in 1999. The monitored facilities were past-practice liquid waste disposal facilities and consisted of six cribs and nineteen ''specific retention'' cribs and trenches. Monitoring consisted of spectral gamma-ray and neutron moisture logging. All data are included in Appendix B. The isotopes {sup 137}Cs, {sup 60}Co, {sup 235}U, {sup 238}U, and {sup 154}Eu were identified on spectral gamma logs from boreholes monitoring the PUREX specific retention facilities; the isotopes {sup 137}Cs, {sup 60}Co, {sup 125}Sb, and {sup 154}Eu were identified on the logs from boreholes at the BC Controlled Area cribs and trenches; and {sup 137}Cs, {sup 60}Co, and {sup 125}Sb were, identified on the logs from boreholes at the BX specific retention trenches. Three boreholes in the BC Controlled Area and one at the BX trenches had previous spectral gamma logs available for comparison with 1999 logs. Two of those logs showed that changes in the subsurface distribution of {sup 137}CS and/or {sup 60}Co had occurred since 1992. Although the changes are not great, they do point to continued movement of contaminants in the vadose zone. The logs obtained in 1999 create a larger baseline for comparison with future logs. Numerous historical gross gamma logs exist from most of the boreholes logged. Qualitative comparison of those logs with the 1999 logs show many substantial changes, most of which reflect the decay of deeper short-lived isotopes, such as {sup 106}Ru and {sup 125}Sb, and the much slower decay of shallower and longer-lived isotopes such as {sup 137}Cs. The radionuclides {sup 137}Cs and {sup 60}Co have moved in two boreholes since 1992. Given the amount of movement and the half-lives of the isotopes, it is expected that they will decay to insignificant amounts before reaching groundwater. However, gamma ray logging cannot detect many of the contaminants of interest such as {sup 99}Tc, NO{sub 3}, or {sup 129}I, all of which can be highly mobile in the vadose zone and, for the radionuclides, have long half-lives.

DG Horton; RR Randall

2000-01-18T23:59:59.000Z

253

The LCLS Timing Event System  

Science Conference Proceedings (OSTI)

The Linac Coherent Light Source requires precision timing trigger signals for various accelerator diagnostics and controls at SLAC-NAL. A new timing system has been developed that meets these requirements. This system is based on COTS hardware with a mixture of custom-designed units. An added challenge has been the requirement that the LCLS Timing System must co-exist and 'know' about the existing SLC Timing System. This paper describes the architecture, construction and performance of the LCLS timing event system.

Dusatko, John; Allison, S.; Browne, M.; Krejcik, P.; /SLAC

2012-07-23T23:59:59.000Z

254

SF 6432-TM Standard Terms and Conditions for Time and Materials Labor Hour Contracts  

NLE Websites -- All DOE Office Websites (Extended Search)

TM (04-95) TM (04-95) Sections II & III SECTION II STANDARD TERMS AND CONDITIONS FOR TIME AND MATERIAL OR LABOR HOURS CONTRACTS INDEX OF CLAUSES THE FOLLOWING CLAUSES APPLY TO THIS CONTRACT AS INDICATED UNLESS SPECIFICALLY DELETED, OR EXCEPT TO THE EXTENT THEY ARE SPECIFICALLY SUPPLEMENTED OR AMENDED IN WRITING IN THE SIGNATURE PAGE OR SECTION I. No. Title Page "A" Clauses apply to Requests for Quotation and Contracts at any value A10 Definitions 2 A11 Unclassified Contract 2 A12 Assignment 2 *A13 Releases Void 2 *A14 Notice of Labor Disputes 2 *A16 Contractor's Information 2 A17 Delegated Representatives 2 *A18 Defense Priority and Allocation System 2 A19 Terms and Conditions 3 *A20 Permits 3 *A23 Applicable Law 3 *A24 Contractor Records Retention 3 A25 Commerce in Explosives, Firearms and

255

Time  

NLE Websites -- All DOE Office Websites (Extended Search)

Judges 9:00- 9:25 Materials Science Mathew Cherukara Shock Induced Chemistry of NiAl Nano-Composites Chen, X. Gyrya, V. 9:25- 9:50 Materials Science Christian Sorensen Explosive...

256

Spectral analysis of microarray gene expression time series data of Plasmodium falciparum  

Science Conference Proceedings (OSTI)

We propose a new strategy to analyse the periodicity of gene expression profiles using Singular Spectrum Analysis (SSA) and Autoregressive (AR) model based spectral estimation. By combining the advantages of SSA and AR modelling, more ... Keywords: SSA, autoregressive spectral estimation model, bioinformatics, drug discovery, gene expression profiles, gene target, microarray time series analysis, plasmodium falciparum, singular spectrum analysis

Liping Du; Shuanhu Wu; Alan Wee-Chung Liew; David K. Smith; Hong Yan

2008-07-01T23:59:59.000Z

257

All Time, All the Time: Improving NIST Radio  

Science Conference Proceedings (OSTI)

... need for manual adjustments when Daylight Saving Time begins and ends, and allowing automatic resetting of clocks following a power outage.

2011-10-06T23:59:59.000Z

258

A Time Bucket Formulation for the TSP with Time Windows  

E-Print Network (OSTI)

Nov 5, 2009 ... Abstract: The Traveling Salesman Problem with Time Windows (TSPTW) is the problem of finding a minimum-cost path visiting a set of cities ...

259

NIST: A Walk Through Time - World Time Scales  

Science Conference Proceedings (OSTI)

... A Walk Through Time - Home Page ... and technologists recognized the inadequacy of timekeeping based on the motion of the Earth, which fluctuates ...

2010-10-05T23:59:59.000Z

260

www.mdpi.org/molecules How Many Drugs Are Catecholics  

E-Print Network (OSTI)

Abstract: By examination of the 8659 drugs recorded in the Comprehensive Medicinal Chemistry (CMC) database, 78 catecholics (including five pyrogallolics) were identified, of which 17 are currently prescribed by FDA. Through analyzing the substitutent patterns, ClogPs and O-H bond dissociation enthalpies (BDEs) of the catecholic drugs, some molecular features that may benefit circumventing the toxicity of catecholics were revealed: i) strong electron-donating substituents are excluded; ii) ClogP catecholic drugs are of importance in designing or screening catecholic antioxidants.

Da-peng Yang; Hong-fang Ji; Guang-yan Tang; Wei Ren; Hong-yu Zhang

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Finding of No Significant Impact/Construction of a New Office Building, Child-Care Facility, Parking Garage, and Storm-Water Retention Pond  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

NEW OFFICE BUILDING, CHILD-CARE FACILITY, PARKING GARAGE, NEW OFFICE BUILDING, CHILD-CARE FACILITY, PARKING GARAGE, AND STORM- WATER RETENTION POND AGENCY: U.S. Department of Energy (DOE) ACTION: Finding of No Significant Impact (FaNS I) SUMMARY: The DOE has prepared an Environmental Assessment (EA), DOE/EA-1444, to analyze the potential environmental consequences of a major facilities construction effort at the Morgantown, West Virginia, campus of the National Energy Technology Laboratory (NETL). Within the existing NETL site, the DOE would construct a new 3-story office building with 48,000 ft2 of usable office space, sufficient to accommodate approximately 135 employees. Existing parking space lost to the proposed new office building would be replaced by construction of a 3-level parking garage plus the addition of one or more new paved parking areas. Several

262

Commercial potential for thermal & magnetic sensitive polymer in drug delivery applications  

E-Print Network (OSTI)

Thermal and magnetically sensitive polymers are a new class of materials with unique properties suitable for applications in drug delivery. Specifically, these polymers can be combined with a drug reservoir to make a drug ...

Edward, Jonathan M. (Jonathan Mark)

2008-01-01T23:59:59.000Z

263

Overview of the US-Japan collaborative investigation on hydrogen isotope retention in neutron-irradiated and ion-damaged tungsten  

Science Conference Proceedings (OSTI)

Plasma-facing components (PFCs) will be exposed to 14 MeV neutrons from deuterium-tritium (D-T) fusion reactions, and tungsten, a candidate PFC for the divertor in ITER, is expected to receive a neutron dose of 0.7 displacement per atom (dpa) by the end of operation in ITER. The effect of neutron-irradiation damage has been mainly simulated using high-energy ion bombardment. While this prior database of results is quite valuable for understanding the behavior of hydrogen isotopes in PFCs, it does not encompass the full range of effects that must be considered in a practical fusion environment due to short penetration depth, damage gradient, high damage rate, and high PKA energy spectrum of the ion bombardment. In addition, neutrons change the elemental composition via transmutations, and create a high radiation environment inside PFCs, which influence the behavior of hydrogen isotope in PFCs, suggesting the utilization of fission reactors is necessary for neutron irradiation. Therefore, the effort to correlate among high-energy ions, fission neutrons, and fusion neutrons is crucial for accurately estimating tritium retention under a neutron-irradiation environment. Under the framework of the US-Japan TITAN program, tungsten samples (99.99 at. % purity from A.L.M.T. Co.) were irradiated by neutron in the High Flux Isotope Reactor (HFIR), ORNL, at 50 and 300C to 0.025, 0.3, and 1.2 dpa, and the investigation of deuterium retention in neutron-irradiation was performed in the INL Tritium Plasma Experiment (TPE), the unique high-flux linear plasma facility that can handle tritium, beryllium and activated materials. This paper reports the recent results from the comparison of ion-damaged tungsten via various ion species (2.8 MeV Fe2+, 20 MeV W2+, and 700 keV H-) with that from neutron-irradiated tungsten to identify the similarities and differences among them.

Masashi Shimada; Y. Hatano; Y. Oya; T. Oda; M. Hara; G. Cao; M. Kobayashi; M. Sokolov; H. Watanabe; B. Tyburska; Y. Ueda; P. Calderoni

2011-09-01T23:59:59.000Z

264

Facilitators of and Barriers to Methadone Maintenance Treatment Enrollment among Opioid Injecting Drug Users in Hai Phong, Vietnam, 2011  

E-Print Network (OSTI)

people who use drugs in Cambodia, China, Malaysia and Vietpeople who use drugs in Cambodia, China, Malaysia and Vietprovince, China. International Journal of Drug Policy, 20,

Nguyen, Nguyen Binh

2012-01-01T23:59:59.000Z

265

Partnership Status, Continued Drug Use and Treatment Adherence among Newly Enrolled Methadone Maintenance Therapy Patients in China  

E-Print Network (OSTI)

Therapy Patients in China Abstract Introduction: Drug users'among young male drug users in southwest China. AIDS, 10 (W. , Improving drug addiction treatment in China. Addiction,

Wan, Dai

2012-01-01T23:59:59.000Z

266

Time-lock Puzzles and Timed-release Crypto  

Science Conference Proceedings (OSTI)

Our motivation is the notion of ``timed-release crypto,'''' where the goal is to encrypt a message so that it can not be decrypted by anyone, not even the sender, until a pre-determined amount of time has passed. The goal is to ``send information into ...

R. L. Rivest; A. Shamir; D. A. Wagner

1996-02-01T23:59:59.000Z

267

Reactor control rod timing system  

DOE Patents (OSTI)

A fluid driven jet-edge whistle timing system for control rods of a nuclear reactor for producing real-time detection of the timing of each control rod in its scram operation. An important parameter in reactor safety, particularly for liquid metal fast breeder reactors (LMFBR), is the time deviation between the time the control rod is released and the time the rod actually reaches the down position. The whistle has a nearly pure tone signal with center frequency (above 100 kHz) far above the frequency band in which the energy of the background noise is concentrated. Each control rod can be fitted with a whistle with a different frequency so that there is no ambiguity in differentiating the signal from each control rod.

Wu, Peter T. K. (Clifton Park, NY)

1982-01-01T23:59:59.000Z

268

VARIABLE TIME-INTERVAL GENERATOR  

DOE Patents (OSTI)

This patent relates to a pulse generator and more particularly to a time interval generator wherein the time interval between pulses is precisely determined. The variable time generator comprises two oscillators with one having a variable frequency output and the other a fixed frequency output. A frequency divider is connected to the variable oscillator for dividing its frequency by a selected factor and a counter is used for counting the periods of the fixed oscillator occurring during a cycle of the divided frequency of the variable oscillator. This defines the period of the variable oscillator in terms of that of the fixed oscillator. A circuit is provided for selecting as a time interval a predetermined number of periods of the variable oscillator. The output of the generator consists of a first pulse produced by a trigger circuit at the start of the time interval and a second pulse marking the end of the time interval produced by the same trigger circuit.

Gross, J.E.

1959-10-31T23:59:59.000Z

269

Biosynthetic engineering for the assembly of better drugs  

E-Print Network (OSTI)

The declining prospects of innovator pharmaceutical companies have been attributed to their inability to discover leads that bind to novel protein domains. All of the 21,000-odd drug products that have ever been approved ...

Yadav, Vikramaditya Ganapati

2013-01-01T23:59:59.000Z

270

FACT SHEET ON THE CONSEQUENCES OF A FAILED DRUG TEST  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

SHEET ON THE CONSEQUENCES OF A POSITIVE DRUG TEST SHEET ON THE CONSEQUENCES OF A POSITIVE DRUG TEST The Secretary has determined that applicants for, and holders of, a DOE "Q" or "L" access authorization (security clearance) will be in Testing Designated Positions (TDP) as specified in DOE Order 3792.3, Drug-Free Federal Workplace Testing Implementation Program, for federal employees, and Title 10 Code of Federal Regulations, Part 707, Workplace Substance Abuse Programs at DOE Sites, for contractor employees. Accordingly, individuals who are either in, or are selected for, a TDP are subject to applicant, random, and "for cause" testing. The information below summarizes the consequences of a positive test for drugs for each category of

271

Implementation Guidance, Drug Testing - December 3, 2007 | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Implementation Guidance, Drug Testing - December 3, 2007 Implementation Guidance, Drug Testing - December 3, 2007 Implementation Guidance, Drug Testing - December 3, 2007 December 3, 2007 Implementation guidance for applicants for, and holders of, a Department of Energy (DOE) Q or L access authorization (security clearance) selected for Testing Designated Positions (TDP) As established in his memorandum dated September 14, 2007, the Secretary has determined that applicants for, and holders of, a Department of Energy (DOE) Q or L access authorization (security clearance) will be in Testing Designated Positions (TDP) as specified in DOE Order 3792.3, Drug-Free Federal Workplace Testing Implementation Program, for Federal employees, and Title 10, Code of Federal Regulations, Part 707, Workplace Substance Abuse Programs at DOE Sites, for contractor employees. Accordingly,

272

Essays on prescription drug benefits in Medicare managed care  

E-Print Network (OSTI)

In this thesis, I estimate a structural demand model for prescription drug benefits by Medicare beneficiaries using data from the Medicare HMO program. I then use the utility parameter estimates to explore other questions ...

Hall, Anne Elizabeth, 1971-

2005-01-01T23:59:59.000Z

273

Nanoporous silicon as drug delivery systems for cancer therapies  

Science Conference Proceedings (OSTI)

Porous silicon nanoparticles have been established as excellent candidates for medical applications as drug delivery devices, due to their excellent biocompatibility, biodegradability, and high surface area. The simple fabrication method by electrochemical ...

Sazan M. Haidary; Emma P. Córcoles; Nihad K. Ali

2012-01-01T23:59:59.000Z

274

Biocompatibility of an implantable ophthalmic drug delivery device  

E-Print Network (OSTI)

Diseases of the posterior eye present clinicians with a treatment challenge mainly due to the region's inaccessible location. Several drugs, including those available for the treatment of exudative age-related macular ...

Cohen, Sarah J. (Sarah Jennifer)

2007-01-01T23:59:59.000Z

275

Neutrons' view of hydrogen yields insight into HIV drug design...  

NLE Websites -- All DOE Office Websites (Extended Search)

Neutrons' view of hydrogen yields insight into HIV drug design ORNL-led study demonstrates relevance of neutrons in biomedical research An ORNL-led team used neutrons to study the...

276

Molecular research suggests shift needed in how drugs are created  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular research suggests shift needed in how drugs are created -Press: Release Number: PR-UIUC-05-2 -Source: University of Illinois at Urbana Champaign -Date issued: October 3,...

277

Carbon dating impacts non-proliferation, drug research and climate...  

NLE Websites -- All DOE Office Websites (Extended Search)

25 years of carbon dating. Carbon dating impacts non-proliferation, drug research and climate change Anne M Stark, LLNL, (925) 422-9799, stark8@llnl.gov Lawrence Livermore...

278

A fully implantable intracochlear drug delivery device : development and characterization  

E-Print Network (OSTI)

In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

Swan, Erin Eileen Leary, 1976-

2009-01-01T23:59:59.000Z

279

Needle-free drug delivery using shock wave techniques  

E-Print Network (OSTI)

A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

Pavlov, Atanas (Atanas Ivanov)

2006-01-01T23:59:59.000Z

280

Essays in time and risk  

E-Print Network (OSTI)

lists yield systematically higher discount rates and utilityList methodology: identifying time preferences with MPLs and utilityrisk price list to inform curvature of the utility function

Sprenger, Charles

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Time-critical information services  

Science Conference Proceedings (OSTI)

Emergency medical services have never been more ready for the implementation of time-critical interorganizational information services for the public good.

Thomas A. Horan; Benjamin L. Schooley

2007-03-01T23:59:59.000Z

282

Time and Frequency Users Manual  

Science Conference Proceedings (OSTI)

... 9 TERMS USED 11 ... 135 GLOSSARY 137 INDEX ... The OIL INDUSTRY needs accurate timing to help automate oil well drilling, especially offshore. ...

2002-01-02T23:59:59.000Z

283

Automated Computer Time Service (ACTS)  

Science Conference Proceedings (OSTI)

... provided since 1988 for users who need to synchronize computer clocks to ... For computers with Internet access, the Internet Time Service should be ...

2013-02-22T23:59:59.000Z

284

Real time wind turbine simulator.  

E-Print Network (OSTI)

??A novel dynamic real-time wind turbine simulator (WTS) is developed in this thesis, which is capable of reproducing dynamic behavior of real wind turbine. The… (more)

Gong, Bing

2007-01-01T23:59:59.000Z

285

Influence of preparative techniques on the structure, stability and dissolution of amorphous drugs.  

E-Print Network (OSTI)

??Poorly soluble drugs are becoming increasingly common in the pharmaceutical setting. Such drugs often exhibit dissolution rate-limited absorption and therefore methods to increase the dissolution… (more)

Karmwar, Pranav

2011-01-01T23:59:59.000Z

286

Design and in vitro development of resorbable urologic drug delivery device  

E-Print Network (OSTI)

Implantable, controlled release drug delivery devices offer several advantages over systemic oral administration routes and immediate drug release treatments including direct therapy to target organ, more continuous ...

Tobias, Irene S. (Irene Sophie)

2008-01-01T23:59:59.000Z

287

A Simulator for Timed CSP  

E-Print Network (OSTI)

Time is an integral aspect of computer systems. It is essential for modelling a system’s performance, but may also affect its safety or security. Timed CSP [Sch00] conservatively extends the process algebra CSP with timed primitives, where real numbers ? 0 model how time passes with reference to a single, conceptually global, clock. While there have been approaches for model checking Timed CSP ([Sch00, DHSZ06]), to the best of our knowledge we are the first to present a simulator for Timed CSP. Here, we restrict time to rational values only. Theoretically, this limits the expressibility of the language. Practically, this limitation turns out to be negligible (for instance all examples of Schneider’s book [Sch00] can be dealt with in our simulator). The simulator is the outcome of an undergraduate project at Swansea University [Dra11]. Our Timed CSP simulator extends the open source tool ProB [Leu]. ProB’s CSP simulator works as follows: The CSP specification is analyzed by a parser (written in Haskell) and translated to a representation in Prolog. A CSP Interpreter (in Prolog) stores the “firing rules” of CSP’s operational semantics. The Simulator (also in Prolog) determines the actions available and the resultant states. A GUI (written in Tcl/Tk) allows the user to interact with the Simulator. Timed CSP is closed under rational time [DNR11]. Consider, for example, the following firing rule ( t ? stands for a timed transition of duration t): P d? ? P ? (P ?d Q) d?

Marc Dragon; Andy Gimblett; Markus Roggenbach; Jens Bendisposto; Cliff Jones; Michael Leuschel; Er Romanovsky; Tiziana Margaria; Julia Padberg; Gabriele Taentzer; Marc Dragon; Andy Gimblett; Markus Roggenbach

2011-01-01T23:59:59.000Z

288

Electric Time in Quantum Cosmology  

E-Print Network (OSTI)

Effective quantum cosmology is formulated with a realistic global internal time given by the electric vector potential. New possibilities for the quantum behavior of space-time are found, and the high-density regime is shown to be very sensitive to the specific form of state realized.

Stephon Alexander; Martin Bojowald; Antonino Marciano; David Simpson

2012-12-10T23:59:59.000Z

289

Time-Constrained Loop Pipelining  

Science Conference Proceedings (OSTI)

This paper addresses the problem of Time-Constrained Loop Pipelining, i.e. given a fixed throughput, finding a schedule of a loop which minimizes resource requirements. This paper proposes a methodology, called TCLP, based on dividing the problem into ... Keywords: loop pipelining, scheduling, timing and resource contraints, register optimization

Fermin Sanchez

1995-12-01T23:59:59.000Z

290

Beam Time Allocation Committee (BAC)  

NLE Websites -- All DOE Office Websites (Extended Search)

Time Allocation Committee (BAC) Time Allocation Committee (BAC) Charter Purpose: Allocates general user beam time by instrument to promote diverse and high- impact science and a broad-based user community to meet DOE and NSSD goals. Participants: BAC Chair (appointed by NSSD Director), Instrument Group Leaders, User Office Schedule: Tied to proposal calls - expected to meet at least 2 times/year with meetings scheduled about 6 weeks after the proposal call has closed and at least 1 month prior to scheduled operations. Process: 1. Instrument Group Leaders (with group members): a. Confirm feasibility (equipment requirements and instrument capabilities) and safe operations b. Review amount of beam time requested and adjust as needed with consideration for instrument and sample environment availability.

291

From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement  

E-Print Network (OSTI)

interviews that I conducted. Because I am using a nonprobability snowball sampling technique,interviews with the members of several different drug policy reform organizations. I employed a snowball sampling technique

Heddleston, Thomas Reed

2012-01-01T23:59:59.000Z

292

Finding patterns in timed data with spike timing dependent plasticity  

E-Print Network (OSTI)

My research focuses on finding patterns in events - in sequences of data that happen over time. It takes inspiration from a neuroscience phenomena believed to be deeply involved in learning. I propose a machine learning ...

Oliveira, Alexandre (Alexandre S.)

2012-01-01T23:59:59.000Z

293

Toward real-time modeling of human heart ventricles at cellular resolution: simulation of drug-induced arrhythmias  

Science Conference Proceedings (OSTI)

We have developed a highly efficient and scalable cardiac electrophysiology simulation capability that supports groundbreaking resolution and detail to elucidate the mechanisms of sudden cardiac death from arrhythmia. We can simulate thousands of heartbeats ...

Arthur A. Mirin; David F. Richards; James N. Glosli; Erik W. Draeger; Bor Chan; Jean-luc Fattebert; William D. Krauss; Tomas Oppelstrup; John Jeremy Rice; John A. Gunnels; Viatcheslav Gurev; Changhoan Kim; John Magerlein; Matthias Reumann; Hui-Fang Wen

2012-11-01T23:59:59.000Z

294

Upgrade of NSLS timing system  

SciTech Connect

We report on the progress of the new NSLS timing system. There are three types of requirements for NSLS timing system: clocks, synchronization and trigger circuits. All ring revolution frequency clocks are generated using ECL and high speed TTL logic. The synchronization circuits allows to fill both storage rings with any bunch pattern. The triggers are generated by using commercially available digital delay generators. The delay unit`s outputs are ultrastable, with a resolution of 5 ps, and are programmed by computer via IEEE 488 interface. The block diagrams, description of all major timing components and the present status are provided in this paper.

Singh, O.; Ramamoorthy, S.; Sheehan, J.; Smith, J.

1995-05-01T23:59:59.000Z

295

Silicon photomultiplier timing performance study  

E-Print Network (OSTI)

Many characteristics of Silicon Photomultipliers can be tuned with temperature and operation voltage. We present preliminary results of a study of the effect of these two operation parameters on the time resolution of large active area Multi-Pixel Photon Counters (MPPCs) manufactured by Hamamatsu. Measurements at -10 C, 0 C, and 10 C at different bias voltages were performed. The time resolution is best at low temperature and high over-voltage. Most significant improvements can be achieved in cases with low number of fired pixels (40 pixels) the effect of temperature and operation voltage becomes smaller. The timing performance still improves with decreasing temperature (~ factor of 2) but it hardly depends on the operation voltage. The study shows, that especially in applications where only few photons are available for detection a careful optimization of temperature and operation voltage are advisable to obtain optimum timing results with the MPPC.

Gama Ahmed; Paul Bühler; Johann Marton; Ken Suzuki

2010-06-21T23:59:59.000Z

296

Logarithmic time parallel Bayesian inference  

Science Conference Proceedings (OSTI)

I present a parallel algorithm for exact probabilistic inference in Bayesian networks. For polytree networks with n variables, the worstcase time complexity is O(logn) on a CREW PRAM (concurrent-read, exclusive-write parallel random-access ...

David M. Pennock

1998-07-01T23:59:59.000Z

297

The structure of cosmic time  

E-Print Network (OSTI)

Following the approach of Julien Lesgourgues [1], we analyze the mathematical structure of the time co-ordinate of present day cosmological models, where these models include a cosmological constant term to account for the observed acceleration of the universe [2], [3]: we find that in all cases, except for a set of measure zero in the parameter space, the time is given by an (abelian) integral on a torus; the imaginary period of this integral then gives a natural periodicity in imaginary time for the universe; following Stephen Hawking [4], [5], this periodicity may be interpreted either as giving a fundamental mass scale for the universe, or (using Planck’s constant) a fundamental temperature, or both. The precise structure that emerges suggests that the structure of time can be regarded as an order parameter arising perhaps in a phase transition in the early universe; one might hope that this structure

George Sparling

2006-01-01T23:59:59.000Z

298

A real time priority scheduler  

Science Conference Proceedings (OSTI)

The real time priority scheduler reported herein evolved from a design effort to provide software aids for handling the interrupts that occur in hybrid computation. Since these interrupts are both internal and external (i.e., generated internal and external ...

Karl Ramsay; Jon C. Strauss

1966-01-01T23:59:59.000Z

299

Time-Constrained Loop Pipelining  

E-Print Network (OSTI)

This paper addresses the problem of Time-Constrained Loop Pipelining, i.e. given a fixed throughput, finding a schedule of a loop which minimizes resource requirements. We propose a methodology, called TCLP, based on dividing the problem into two simpler and independent tasks: retiming and scheduling. TCLP explores different sets of resources, searchingfor a maximum resource utilization. This reduces area requirements. After a minimum set of resourceshas been found, the execution throughput is increased and the number of registers required by the loop schedule is reduced. TCLP attempts to generate a schedule which minimizes cost in time and area (resources and registers). The results show that TCLP obtains optimal schedules in most cases. 1 Introduction This paper presents TCLP, a methodology to solve TimeConstrained Loop Pipelining. TCLP is NP-complete [3]. Two types of timing constraints (TCs) have been considered in the literature: local TCs to specify minimum and/or maximum TCs ...

Fermn Sanchez; Jordi Cortadella

1995-01-01T23:59:59.000Z

300

Discrete space-time symmetries  

SciTech Connect

Symmetries have always fascinated human beings; they are found in nature, art, and architecture. Physicists, like other scientists have often used symmetries as a basis of their understanding of nature. When the dynamics is unknown, symmetries serve to delineate and define it. When the dynamics is known, symmetries are used to study structure. These two lectures review the theory and present understanding and status of two discrete space-time symmetries,, namely parity (P) and time reversal (T).

Henley, E.M.

1992-12-31T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Discrete space-time symmetries  

SciTech Connect

Symmetries have always fascinated human beings; they are found in nature, art, and architecture. Physicists, like other scientists have often used symmetries as a basis of their understanding of nature. When the dynamics is unknown, symmetries serve to delineate and define it. When the dynamics is known, symmetries are used to study structure. These two lectures review the theory and present understanding and status of two discrete space-time symmetries,, namely parity (P) and time reversal (T).

Henley, E.M.

1992-01-01T23:59:59.000Z

302

Reduction in maximum time uncertainty of paired time signals  

DOE Patents (OSTI)

Reduction in the maximum time uncertainty (t/sub max/ - t/sub min/) of a series of paired time signals t/sub 1/ and t/sub 2/ varying between two input terminals and representative of a series of single events where t/sub 1/ less than or equal to t/sub 2/ and t/sub 1/ + t/sub 2/ equals a constant, is carried out with a circuit utilizing a combination of OR and AND gates as signal selecting means and one or more time delays to increase the minimum value (t/sub min/) of the first signal t/sub 1/ closer to t/sub max/ and thereby reduce the difference. The circuit may utilize a plurality of stages to reduce the uncertainty by factors of 20 to 800.

Theodosiou, G.E.; Dawson, J.W.

1981-02-11T23:59:59.000Z

303

Gas generation and retention in Tank 101-SY: A summary of laboratory studies, tank data, and information needs  

DOE Green Energy (OSTI)

Chemical and radioactive wastes from processes used to separate plutonium from uranium are stored in underground tanks at the Hanford Site in Washington state. In March 1981, it was observed that the volume of wastes in Tank 101-SY slowly increased, followed by a rapid decrease and the venting of large quantities of gases. These cycles occurred every 8 to 15 weeks and continue to the present time. Subsequent analyses showed that these gases were composed primarily of hydrogen and nitrous oxide (N{sub 2}O). In response to the potential for explosion and release of hazardous materials to the environment, laboratory programs were initiated at Argonne National Laboratory (ANL), Georgia Institute of Technology (GIT), Pacific Northwest Laboratory (PNL), and Westinghouse Hanford Company (WHC), to develop a better understanding of the physical and chemical processes occurring in this waste tank. An aggressive sampling and analysis effort is also under way to characterize the wastes as fully as possible. These efforts will provide a technically defensible basis for safety analyses and future mitigation/remediation of the tank and its contents.

Pederson, L.R. (comp.) (Pacific Northwest Lab., Richland, WA (United States)); Ashby, E.C. (Georgia Inst. of Tech., Atlanta, GA (United States)); Jonah, C.; Meisel, D. (Argonne National Lab., IL (United States)); Strachan, D.M. (Pacific Northwest Lab., Richland, WA (United States))

1992-06-01T23:59:59.000Z

304

X-ray Spectroscopy for Quality Control of Chemotherapy Drugs  

Science Conference Proceedings (OSTI)

We develop a method, employing Compton peak standardization and the use of matrix-matched spiked samples with Total Reflection X-ray Fluorescence (TXRF), for the determination of platinum plasma concentrations of patients undergoing chemotherapy with Pt-bearing drugs. Direct blood plasma analysis attains Pt detection limits of 70 ng/ml. Measurement results of prescribed drug doses are compared to achieved blood Pt concentrations indicating a lack of expected correlations. Direct analysis of Pt-containing infused drugs from a variety of suppliers indicates cases of abnormal concentrations which raises quality control issues. We demonstrate the potential usefulness of the method for pharmacokinetic studies or for routine optimization and quality control of Pt chemotherapy treatments.

Greaves, E. D.; Barros, H.; Bermudez, J.; Sajo-Bohus, L. [Universidad Simon Bolivar, Apartado 89000, Caracas 1080A (Venezuela); Angeli-Greaves, M. [Universidad Central de Venezuela, Apartado 90373 Caracas 1083A (Venezuela)

2007-10-26T23:59:59.000Z

305

Drug-Free Workplace Program UT-B Contracts Page 1 of 1  

E-Print Network (OSTI)

Drug-Free Workplace Program UT-B Contracts Sep 2012 Page 1 of 1 drug-free-workplace-ext-sep12 DRUG-FREE, the Seller and its subcontractors working on the project site must maintain a drug-free workplace program. (B) If the Seller is an out-of-state entity, the Company may upon request allow a drug-free workplace

Pennycook, Steve

306

Fission Product Impact Reduction via Protracted In-core Retention in Very High Temperature Reactor (VHTR) Transmutation Scenarios  

E-Print Network (OSTI)

The closure of the nuclear fuel cycle is a topic of interest in the sustainability context of nuclear energy. The implication of such closure includes considerations of nuclear waste management. This originates from the fact that a closed fuel cycle requires recycling of useful materials from spent nuclear fuel and discarding of non-usable streams of the spent fuel, which are predominantly the fission products. The fission products represent the near-term concerns associated with final geological repositories for the waste stream. Long-lived fission products also contribute to the long-term concerns associated with such repository. In addition, an ultimately closed nuclear fuel cycle in which all actinides from spent nuclear fuels are incinerated will result in fission products being the only source of radiotoxicity. Hence, it is desired to develop a transmutation strategy that will achieve reduction in the inventory and radiological parameters of significant fission products within a reasonably short time. In this dissertation, a transmutation strategy involving the use of the VHTR is developed. A set of specialized metrics is developed and applied to evaluate performance characteristics. The transmutation strategy considers six major fission products: 90Sr, 93Zr, 99Tc, 129I, 135Cs and 137Cs. In this approach, the unique core features of VHTRs operating in equilibrium fuel cycle mode of 405 effective full power days are used for transmutation of the selected fission products. A 30 year irradiation period with 10 post-irradiation cooling is assumed. The strategy assumes no separation of each nuclide from its corresponding material stream in the VHTR fuel cycle. The optimum locations in the VHTR core cavity leading to maximized transmutation of each selected nuclides are determined. The fission product transmutation scenarios are simulated with MCNP and ORIGEN-S. The results indicate that the developed fission product transmutation strategy offers an excellent potential approach for the reduction of inventories and radiological parameters, particularly for long-lived fission products (93Zr, 99Tc, 129I and 135Cs). It has been determined that the in-core transmutation of relatively short-lived fission products (90Sr and 137Cs) has minimal advantage over a decay-only scenario for these nuclides. It is concluded that the developed strategy is a viable option for the reduction of radiotoxicity contributions of the selected fission products prior to their final disposal in a geological repository. Even in the cases where the transmutation advantage is minimal, it is deemed that the improvement gained, coupled with the virtual storage provided for the fission products during the irradiation period, makes the developed fission product transmutation strategy advantageous in the spent fuel management scenarios. Combined with the in-core incineration options for TRU, the developed transmutation strategy leads to potential achievability of engineering time scales in the comprehensive nuclear waste management.

Alajo, Ayodeji Babatunde

2010-05-01T23:59:59.000Z

307

Tough Times for the Muskrats  

NLE Websites -- All DOE Office Websites (Extended Search)

Tough Times for the Muskrats Tough Times for the Muskrats Nature Bulletin No. 3 February 24, 1945 Forest Preserve District of Cook County Clayton F Smith, President Roberts Mann, Superintendent of Conservation TOUGH TIMES FOR THE MUSKRATS This has been a sorry year for the muskrats. The long drought, last summer and fall, dried up many of the smaller marshes and ponds where they had been living and forced them to migrate overland to new homes. Many undoubtedly were killed while enroute by mink, hawks, or dogs. Even the larger marshes and ponds were made smaller and more shallow by the drought and now this severe winter, with its long, bitter cold, has caused many of them to freeze solid to the very bottom; thus sealing the muskrats up in their lodges and preventing them from swimming around under the ice to get food.

308

Time-Off Awards Scale  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

/1/2010 /1/2010 TIME OFF AWARD SCALE The following chart is recommended and should be used unless another time-off award scale has been adopted by the servicing human resources office. TIME OFF SCALE VALUE OF THE EMPLOYEE'S CONTRIBUTION HOURS TO BE AWARDED MODERATE - A contribution to a product, program or service to the public which is of sufficient value to merit formal recognition. Beneficial change or modification of operating principles or procedures. 1 - 10 Hours SUBSTANTIAL - An important contribution to the value of a product, activity, program or service to the public. Significant change or modification or operating principles or procedures. 11 - 20 Hours HIGH - A significant contribution to the value of a product, activity, program or service to

309

May 2008 Y-12 Times  

NLE Websites -- All DOE Office Websites (Extended Search)

5 5 May 2008 www.y12.doe.gov/news/times.php P.O. Box 2009 Oak Ridge, TN 37831-8245 Managing Editor Melissa Leinart 865-574-1621 (6ml) Associate Editors Amy Alley Heidi Spurling Layout/Design Lisa Harris Contributors Ellen Boatner Ken Davis Kathy Fahey Stuart Hames Sharon McConathy Patrick McCoy I N S I D E Page 3 Fire department members come to the rescue Page 4 Driving green to protect our natural resources Page 5 73s: Best regards from Y-12's hams Page8 What's the secret? Mary Murray Brett Pate Ray Smith Donna Watson Bill Wilburn Lisa Xiques times times the B&W Technical Services Y-12, LLC, a partnership between Babcock & Wilcox Technical Services Group Inc. and Bechtel National Inc., operates the Y-12 National Security Complex. When you see information regarding the recent Voluntary Separation Payment

310

Dielectric Analog Space-Times  

E-Print Network (OSTI)

We generalize the notion of a dielectric analog Schwarzschild black hole model to analog models of arbitrary space-times; in particular, the approach is not restricted to static space-times. This is done by establishing a correspondence between electrodynamics on a curved, vacuum manifold, with electrodynamics in a general linear dielectric residing in Minkowski space-time. The mapping is not unique, allowing for some freedom in the specification of equivalent materials, which could be useful for exploiting recent developments in the production of metamaterials. Some examples are considered, with special attention paid to the dielectric analog of the exterior Kerr geometry, which is found to be reproducible with regular, linear, dielectrics.

Robert T. Thompson; Jörg Frauendiener

2010-10-08T23:59:59.000Z

311

PRECISION TIME-DELAY CIRCUIT  

DOE Patents (OSTI)

A tine-delay circuit which produces a delay time in d. The circuit a capacitor, an te back resistance, connected serially with the anode of the diode going to ground. At the start of the time delay a negative stepfunction is applied to the series circuit and initiates a half-cycle transient oscillatory voltage terminated by a transient oscillatory voltage of substantially higher frequency. The output of the delay circuit is taken at the junction of the inductor and diode where a sudden voltage rise appears after the initiation of the higher frequency transient oscillations.

Creveling, R.

1959-03-17T23:59:59.000Z

312

Microdistribution and Long-Term Retention of 239Pu (NO3)4 in the Respiratory Tracts of an Acutely Exposed Plutonium Worker and Experimental Beagle Dogs  

Science Conference Proceedings (OSTI)

The long-term retention of inhaled soluble forms of plutonium raises concerns as to the potential health effects in persons working in nuclear energy or the nuclear weapons program. The distributions of long-term retained inhaled plutonium-nitrate [239Pu (NO3)4] deposited in the lungs of an accidentally exposed nuclear worker (Human Case 0269) and in the lungs of experimentally exposed beagle dogs with varying initial lung depositions were determined via autoradiographs of selected histological lung, lymph node, trachea, and nasal turbinate tissue sections. These studies showed that both the human and dogs had a non-uniform distribution of plutonium throughout the lung tissue. Fibrotic scar tissue effectively encapsulated a portion of the plutonium and prevented its clearance from the body or translocation to other tissues and diminished dose to organ parenchyma. Alpha radiation activity from deposited plutonium in Human Case 0269 was observed primarily along the sub-pleural regions while no alpha activity was seen in the tracheobronchial lymph nodes of this individual. However, relatively high activity levels in the tracheobronchial lymph nodes of the beagles indicated the lymphatic system was effective in clearing deposited plutonium from the lung tissues. In both the human case and beagle dogs, the appearance of retained plutonium within the respiratory tract was inconsistent with current biokinetic models of clearance for soluble forms of plutonium. Bound plutonium can have a marked effect on the dose to the lungs and subsequent radiation exposure has the potential increase in cancer risk.

Nielsen, Christopher E.; Wilson, Dulaney A.; Brooks, Antone L.; McCord, Stacey; Dagle, Gerald E.; James, Anthony C.; Tolmachev, Sergei Y.; Thrall, Brian D.; Morgan, William F.

2012-11-01T23:59:59.000Z

313

Time of flight mass spectrometer  

DOE Patents (OSTI)

A time-of-flight mass spectrometer is described in which ions are desorbed from a sample by nuclear fission fragments, such that desorption occurs at the surface of the sample impinged upon by the fission fragments. This configuration allows for the sample to be of any thickness, and eliminates the need for complicated sample preparation.

Ulbricht, Jr., William H. (Arvada, CO)

1984-01-01T23:59:59.000Z

314

The TESLA Time Projection Chamber  

E-Print Network (OSTI)

A large Time Projection Chamber is proposed as part of the tracking system for a detector at the TESLA electron positron linear collider. Different ongoing R&D studies are reviewed, stressing progress made on a new type readout technique based on Micro-Pattern Gas Detectors.

Nabil Ghodbane

2002-12-12T23:59:59.000Z

315

Waste to Energy Time Activities  

E-Print Network (OSTI)

SEMINAR Waste to Energy Time Activities 9:30-9:40 Brief introduction of participants 9:40-10:10 Presentation of Dr. Kalogirou, "Waste to Energy: An Integral Part of Worldwide Sustainable Waste Management" 10. Sofia Bethanis, "Production of synthetic aggregates for use in structural concrete from waste to energy

Columbia University

316

Predictable real-time software synthesis  

Science Conference Proceedings (OSTI)

Formal theories for real-time systems (such as timed process algebra, timed automata and timed petri nets) have gained great success in the modeling of concurrent timing behavior and in the analysis of real-time properties. However, due to the ineliminable ... Keywords: Formal methods, Program synthesis, Real-time systems

Jinfeng Huang; Jeroen Voeten; Henk Corporaal

2007-08-01T23:59:59.000Z

317

Fact Sheet on the Consequences of a Positive Drug Test  

Energy.gov (U.S. Department of Energy (DOE))

The Secretary has determined that applicants for, and holders of, a DOE “Q” or “L” access authorization (security clearance) will be in Testing Designated Positions (TDP) as specified in DOE Order 3792.3, Drug-Free Federal Workplace Testing Implementation Program, for federal employees, and Title 10 Code of Federal Regulations, Part 707, Workplace Substance Abuse Programs at DOE Sites, for contractor employees.

318

Report on the deuterium retention in CVD coated W on SiC in support of the Ultramet Company’s Small Business Innovation Research (SBIR) project: SOW DE-FG02-07ER84941  

SciTech Connect

A tungsten (W) coated (0.0005-inch thickness) silicon carbide (SiC) (1.0-inch diameter and 0.19-inch thickness) sample was exposed to a divertor relevant high-flux (~1022 m-2s-1) deuterium plasma at 200 and 400°C in the Idaho National Laboratory’s (INL’s) Tritium Plasma Experiment (TPE), and the total deuterium retention was subsequently measured via the thermal desorption spectroscopy (TDS) method. The deuterium retentions were 6.4x1019 m-2 and 1.7x1020 m-2, for 200 and 400°C exposure, respectively. The Tritium Migration Analysis Program (TMAP) was used to analyze the measured TDS spectrum to investigate the deuterium behavior in the W coated SiC, and the results indicated that most of the deuterium was trapped in the W coated layer even at 400°C. This thin W layer (0.0005-inch ~ 13µm thickness) prevented deuterium ions from bombarding directly into the SiC substrate, minimizing erosion of SiC and damage creation via ion bombardment. The shift in the D desorption peak in the TDS spectra from 200 C to 400°C can be attributed to D migration to the bulk material. This unexpectedly low deuterium retention and short migration might be due to the porous nature of the tungsten coating, which can decrease the solution concentration of deuterium atoms.

Masashi Shimada

2012-06-01T23:59:59.000Z

319

Mar_13Times.indd  

NLE Websites -- All DOE Office Websites (Extended Search)

MARCH 2013 MARCH 2013 inside this issue ... FIRP draws to a close Page 2 Reminisce: Y-12 turns 70 Page 4 Russia's secret city Page 5 Development retools its CONOPS Page 6 ... and other Y-12 news Miss an issue? Find us online, http://www.y12.doe.gov/news/times.php MISSION, cont. on pg. 2 The National Nuclear Security Administration's Performance Evaluation Report for B&W Y-12, released Feb. 11, gave "Very Good" ratings to B&W Y-12 in areas related to all three core missions: maintaining the nuclear weapons stockpile, powering the nuclear Navy and nonproliferation. The report evaluates B&W Y-12's performance based on the Performance Evaluation Plan approved at the beginning of fi scal 2012. Programs The Y-12 Times highlighted the success of fi

320

High resolution time interval meter  

DOE Patents (OSTI)

Method and apparatus are provided for measuring the time interval between two events to a higher resolution than reliability available from conventional circuits and component. An internal clock pulse is provided at a frequency compatible with conventional component operating frequencies for reliable operation. Lumped constant delay circuits are provided for generating outputs at delay intervals corresponding to the desired high resolution. An initiation START pulse is input to generate first high resolution data. A termination STOP pulse is input to generate second high resolution data. Internal counters count at the low frequency internal clock pulse rate between the START and STOP pulses. The first and second high resolution data are logically combined to directly provide high resolution data to one counter and correct the count in the low resolution counter to obtain a high resolution time interval measurement.

Martin, A.D.

1986-05-09T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Time-parareal parallel in time integrator solver for time-dependent neutron diffusion equation  

E-Print Network (OSTI)

-dependent spatial flux distribution in nuclear reactor is required for nuclear safety and design. The motivation present a time-parallel algorithm that simulate the kinetic of neutron2 in a nuclear reactor. We consider engine behavior and in particular its energy4 production.5 The flux distribution on the nuclear reactor

322

Why Time is Future Oriented  

E-Print Network (OSTI)

We assume that the universe consists of clusters which in turns have sub-clusters and the sub-clusters have sub-subclusters and so on. Confining to three-dimensional space, it is shown that the universe is expanding if entropy of the universe increases. It is also shown that clocks slow down when time progresses towards future. Our model also justifies the big bang theory.

Shahid N. Afridi; M. Khalid Khan

2004-12-09T23:59:59.000Z

323

General Interest NIST Time and Frequency Publications  

Science Conference Proceedings (OSTI)

... Time and Frequency Users Manual A detailed ... Fundamentals of Time and Frequency An overview of ... Lombardi, The Mechatronics Handbook, 2001. ...

2012-01-31T23:59:59.000Z

324

The Effects of Concept Mapping and Questioning on Students’ Organization and Retention of Science Knowledge While Using Interactive Read-Alouds  

E-Print Network (OSTI)

According to recent assessment data, there is an urgent need to improve students' knowledge of science. It has been suggested that the infusion of reading activities including concept mapping, questioning and interactive read-alouds can help students in learning science concepts. Little or no research has combined these methods to examine its effect on learning. The purpose of this study was to examine and compare concept mapping and questioning on students' organization and retention of science knowledge when used with interactive informational read-alouds of science trade books. This study included 58 third grade students from four homogenous classes who were assigned to either a concept mapping group (experimental group) or a questioning with writing group (comparison group). With the same teacher, the school science specialist, the students completed an eight day unit regarding "soil formation" comprised of read-alouds, discussions and reading comprehension activities. (There were no hands-on, laboratory experiments.) Students were assessed on different types of knowledge. Data were analyzed using a mixed model ANOVA design to determine both within-factors (repeated measure), to show growth, and between-factors, to determine the difference between the two groups. The concept mapping group (experimental group) performed significantly higher than the questioning with writing group (comparison) on (a) relational vocabulary assessment (measuring relational knowledge); (b) multiple-choice assessment (measuring students' ability to identify key ideas); and (c) writing assessment (measuring students' relational thinking, students' ability to retain and recall key information and students' ability to use domain knowledge). The concept mapping group maintained these gains in a delayed assessment. The groups did not differ on individual word knowledge as measured by a matching assessment. Recommendations are provided for teachers and researchers including using concept mapping in teaching science concepts to elementary students in conjunction with science text reading, as well as incorporating technology with computer-generated concept maps using Inspiration software.

Berry, Jaime Leigh

2011-08-01T23:59:59.000Z

325

Real time infrared aerosol analyzer  

DOE Patents (OSTI)

Apparatus for analyzing aerosols in essentially real time includes a virtual impactor which separates coarse particles from fine and ultrafine particles in an aerosol sample. The coarse and ultrafine particles are captured in PTFE filters, and the fine particles impact onto an internal light reflection element. The composition and quantity of the particles on the PTFE filter and on the internal reflection element are measured by alternately passing infrared light through the filter and the internal light reflection element, and analyzing the light through infrared spectrophotometry to identify the particles in the sample.

Johnson, Stanley A. (Countryside, IL); Reedy, Gerald T. (Bourbonnais, IL); Kumar, Romesh (Naperville, IL)

1990-01-01T23:59:59.000Z

326

Public Health ServiceINJECTION DRUG USE AND THE TRANSMISSION OF HIV  

E-Print Network (OSTI)

Preventing drug use and providing substance abuse treatment for persons who inject illicit drugs are crucial to preventing many blood-borne infections, including human immunodeficiency virus (HIV). However, many drug users are not currently in substance abuse treatment programs because of multiple factors including the limited availability of these programs and the lack of readiness or willingness of some drug users to enter substance abuse treatment. Consequently, substantial numbers of drug users continue to inject drugs. This bulletin summarizes new information on preventing transmission of HIV and other blood-borne infections among persons who inject drugs and updates prevention recommendations published in April 1993. *1 The findings of a 1995 workshop on the use of sterile syringes by persons who inject drugs and several recent publications 2,3,4,5,6 indicate that persons who inject drugs should use sterile syringes * * to prevent the transmission of HIV and other blood-borne infectious diseases. These conclusions should be considered by clinicians providing health care to persons who use or inject drugs and by public health professionals planning and carrying out HIV prevention programs for injection drug users (IDUs). Health professionals should inform IDUs that using sterile syringes is safer than reusing syringes, including syringes that have been disinfected with bleach. The information in this bulletin has been prepared for health professionals involved in programs serving persons who inject drugs. Separate educational materials will be prepared to inform drug injectors of these findings.

unknown authors

1997-01-01T23:59:59.000Z

327

Global Warming in Geologic Time  

Science Conference Proceedings (OSTI)

The notion is pervasive in the climate science community and in the public at large that the climate impacts of fossil fuel CO2 release will only persist for a few centuries. This conclusion has no basis in theory or models of the atmosphere/ ocean carbon cycle, which we review here. The largest fraction of the CO2 recovery will take place on time scales of centuries, as CO2 invades the ocean, but a significant fraction of the fossil fuel CO2, ranging in published models in the literature from 20-60%, remains airborne for a thousand years or longer. Ultimate recovery takes place on time scales of hundreds of thousands of years, a geologic longevity typically associated in public perceptions with nuclear waste. The glacial/interglacial climate cycles demonstrate that ice sheets and sea level respond dramatically to millennial-timescale changes in climate forcing. There are also potential positive feedbacks in the carbon cycle, including methane hydrates in the ocean, and peat frozen in permafrost, that are most sensitive to the long tail of the fossil fuel CO2 in the atmosphere.

Archer, David (University of Chicago)

2008-02-27T23:59:59.000Z

328

Tuesday Sep 13 2005 . All times are London time. Sign up now  

E-Print Network (OSTI)

in the future - controlling the movement of drugs around the body to points where they are needed. The Edinburgh Management Media and marketing Entrepreneurship Law and professions Science & technology Investing in China

Leigh, David A.

329

Magnetically-triggered Nanocomposite Membranes: a Versatile Platform for Triggered Drug Release  

E-Print Network (OSTI)

Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field. The dose of drug delivered can be tuned by engineering the phase transition temperature of the nanogel, the loading of nanogels in the membrane, and the membrane thickness, allowing for the delivery of drugs over several orders of magnitude of release rates. The zero-order kinetics of drug release through the membranes permit drug doses from a specific device to be tuned according to the duration of the magnetic field. Drugs over a broad range of molecular weights (500-40,000 Da) can be delivered by the same membrane device. Membrane-to-membrane and cycle-to-cycle reproducibility is demonstrated, suggesting the general utility of these membranes for drug delivery.

Todd Hoare; Brian P. Timko; Jesus Santamaria; Gerardo F. Goya; Silvia Irusta; Debora Lin; Samantha Lau; Robert Langer; Daniel S. Kohane

2011-06-27T23:59:59.000Z

330

Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON  

E-Print Network (OSTI)

Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON Dec. 20, 2012-- The Imagery of pornography: like war porn, torture porn or the standard naked-people porn, drug porn offers up a taste

Fernandez, Eduardo

331

FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein...  

NLE Websites -- All DOE Office Websites (Extended Search)

FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data Taken at ALS FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data...

332

Constructing optimal drug-testing plans using a Bayesian acceptance sampling model  

Science Conference Proceedings (OSTI)

Drug testing has become an accepted strategy for controlling drug use, particularly among individuals in the custody of the criminal justice system. Emphasis has been placed on testing those free in the community, either on pretrial release, probation, ...

Joanna R Baker; Pamela K Lattimore; Lance A Matheson

1993-01-01T23:59:59.000Z

333

Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport  

E-Print Network (OSTI)

Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

Tang, Hua, 1972-

2002-01-01T23:59:59.000Z

334

Functionalized Silicates for Tc Retention  

• Thermal treatment systems planned for the Hanford Waste Treatment Plant (WTP) ... and other Resource Conservation and Recovery Act ... cement pore ...

335

Technetium Retention During LAW Vitrification  

• Technetium in Hanford tank waste is a significant risk contributor in performance assessments for low activity waste disposal

336

Computer modeling reveals how surprisingly potent hepatitis C drug works  

NLE Websites -- All DOE Office Websites (Extended Search)

Hepatitis C computer modeling Hepatitis C computer modeling Computer modeling reveals how surprisingly potent hepatitis C drug works A study reveals how daclatasvir targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment. February 19, 2013 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

337

A Key Target for Diabetes Drugs | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Molten Metal Solidifies into a New Kind of Glass Molten Metal Solidifies into a New Kind of Glass Organic Polymers Show Sunny Potential A New Family of Quasicrystals Cool Muscles: Storing Elastic Energy for Flight A Further Understanding of Superconductivity Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor, which could help scientists design new drugs for type 2 diabetes. (Image courtesy of Katya Kadyshevskaya, The Scripps Research Institute) The three-dimensional (3-D) atomic structure of the human glucagon receptor has been identified by an international team of researchers carrying out

338

jul10_Times.indd  

NLE Websites -- All DOE Office Websites (Extended Search)

7 7 July 2010 www.y12.doe.gov/news/times.php P.O. Box 2009 Oak Ridge, TN 37831-8245 W H A T ' S I N S I D E Page 2 Want to know about Y-12's budget? Read what Darrel Kohlhorst said. Page 3 Y-12 employees get a LIFE Center Pages 4 and 5 Safeguards, Security and Emergency Services' Sentinel Page 6 Employees raise money for Relay for Life Page 8 Refl ections of Y-12's history B&W Technical Services Y-12, LLC, a partnership between Babcock & Wilcox Technical Services Group Inc. and Bechtel National Inc., operates the Y-12 National Security Complex. A newsletter for employees and friends of the Y-12 National Security Complex Managing Editors Amy Alley: alleyab@y12.doe.gov Heidi Spurling: spurlinghw@y12.doe.gov Layout Lisa Harris Contributors Mary Bryant Cynthia Ensor Ryn Etter

339

dec11-Times.indd  

NLE Websites -- All DOE Office Websites (Extended Search)

1 1 December 2011 www.y12.doe.gov/news/times.php P.O. Box 2009 Oak Ridge, TN 37831-8245 W H A T ' S I N S I D E Page 2 Governance Transformation at Y-12 Page 3 Employees bring benefi ts to life Pages 4 and 5 A healthy start to 2012 Page 6 A visit from Christmas past Page 8 Have a plan - just in case B&W Technical Services Y-12, LLC, a partnership between Babcock & Wilcox Technical Services Group Inc. and Bechtel National Inc., operates the Y-12 National Security Complex. A newsletter for employees and friends of the Y-12 National Security Complex Managing Editors Amy Alley: alleyab@y12.doe.gov Heidi Spurling: spurlinghw@y12.doe.gov Layout Lisa Harris Contributors Mary Bryant Ellen Boatner Ashley Douglas Kathy Fahey Scott Fraker John Holbrook David Keim Terry Marlar Jill McNutt

340

Variable residence time vortex combustor  

DOE Patents (OSTI)

A variable residence time vortex combustor including a primary combustion chamber for containing a combustion vortex, and a plurality of louvres peripherally disposed about the primary combustion chamber and longitudinally distributed along its primary axis. The louvres are inclined to impel air about the primary combustion chamber to cool its interior surfaces and to impel air inwardly to assist in driving the combustion vortex in a first rotational direction and to feed combustion in the primary combustion chamber. The vortex combustor also includes a second combustion chamber having a secondary zone and a narrowed waist region in the primary combustion chamber interconnecting the output of the primary combustion chamber with the secondary zone for passing only lower density particles and trapping higher density particles in the combustion vortex in the primary combustion chamber for substantial combustion.

Melconian, Jerry O. (76 Beaver Rd., Reading, MA 01867)

1987-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

1. First Time Designer's Guide  

E-Print Network (OSTI)

Altera provides various tools for development of hardware and software for embedded systems. This handbook complements the primary documentation for these tools by describing how to most effectively use some of these tools. It recommends design styles and practices for developing, debugging, and optimizing embedded systems using Altera-provided tools such as the Software Build Tools for Eclipse and SOPC Builder. The handbook introduces concepts to new users of Altera’s embedded solutions, and helps to increase the design efficiency of the experienced user. This handbook is not a comprehensive reference guide. For general reference and detailed information, refer to the primary documentation cited in this handbook. This first chapter of the handbook contains information about the Altera ® embedded development process and procedures for the first time user. The remaining chapters focus on specific aspects of embedded development for Altera FPGAs. This handbook does not provide information about the Qsys system integration tool.

unknown authors

2011-01-01T23:59:59.000Z

342

Time-Varying z-Transform for the Analysis of Discrete-Time Linear Time Periodic Systems  

Science Conference Proceedings (OSTI)

This article deals with a new representation of linear discrete-time periodic systems. This representation, based on the time-varying z-transform, turns out to be highly efficient in the field of automatic control, when an appropriate choice of ... Keywords: Nyquist criterion, final value theorem, initial value theorem, linear discrete-time periodic systems, time-varying z-transform, time-varying frequency response, time-varying systems

A. Garcia Iturricha; J. Sabatier; A. Oustaloup

2003-07-01T23:59:59.000Z

343

Double iterative optimisation for metabolic network-based drug target identification  

Science Conference Proceedings (OSTI)

The goal of drug discovery is to find molecules that manipulate enzymes in order to increase or decrease the production of desired compounds while incurring minimum side-effects. An important part of this problem is the identification of the target ... Keywords: E coli, bioinformatics, data mining, drug discovery, drug target identification, iterative optimisation, metabolic networks, target enzymes

Bin Song; Padmavati Sridhar; Tamer Kahveci; Sanjay Ranka

2009-05-01T23:59:59.000Z

344

In silico identification of putative drug targets in pseudomonas aeruginosa through metabolic pathway analysis  

Science Conference Proceedings (OSTI)

Comparative genomic analysis between pathogens and the host Homo sapiens has led to identification of novel drug targets. Microbial drug target identification and validation has been the latest trend in pharmacoinformatics. In order to identify a suitable ... Keywords: KEGG, MODELLER, comparative microbial genomics, homo sapiens, homology, kdsA, kdsB, lpxC, potential drug targets, pseudomonas aeruginosa, waaG

Deepak Perumal; Chu Sing Lim; Meena K. Sakharkar

2007-10-01T23:59:59.000Z

345

Towards Integrated Verification of Timed Transition Models  

Science Conference Proceedings (OSTI)

This paper describes an attempt to combine theorem proving and model-checking to formally verify real-time systems in a discrete time setting. The Timed Automata Modeling Environment (TAME) has been modified to provide a formal model for Time Transition ... Keywords: PVS, Real-time, SAL, equivalence verification, model reduction, model-checking, theorem proving

Mark Lawford; Vera Pantelic; Hong Zhang

2006-04-01T23:59:59.000Z

346

Epidemiology of HIV Among Injecting and Non-injecting Drug Users: Current Trends and Implications for Interventions  

E-Print Network (OSTI)

might inject drugs worldwide [1•]. China, the United States,China, the United States, and Russia, the three leading countries for injecting drugChina Russia USA Fig. 1 Number and proportion of HIV infection among injecting drug

Strathdee, Steffanie A.; Stockman, Jamila K.

2010-01-01T23:59:59.000Z

347

March 2009 Y-12 Times  

NLE Websites -- All DOE Office Websites (Extended Search)

3 3 March 2009 www.y12.doe.gov/news/times.php P.O. Box 2009 Oak Ridge, TN 37831-8245 Managing Editors Amy Alley: alleyab@y12.doe.gov Heidi Spurling: spurlinghw@y12.doe.gov Layout/Design Lisa Harris Contributors Ellen Boatner Ken Davis Kathy Fahey Vicki Hinkel Jamie Loveday Mary Murray W H A T ' S I N S I D E W H A T ' S I N S I D E Page 2 Page 2 New UPF room is out of sight Page 3 Page 3 Training simulates terrorist attack, prepares fi rst responders Page 3 Page 3 Tanker cars on the right track Page 5 Page 5 Third-generation employee follows his father's sage advice Page 7 Page 7 Car enthusiasts go into overdrive Brett Pate Ray Smith Donna Watson Mona Wright Lisa Xiques B&W Technical Services Y-12, LLC, a partnership between Babcock & Wilcox Technical Services Group Inc. and Bechtel National Inc., operates the

348

User manual for Timed-CSP Simulator  

E-Print Network (OSTI)

Timed Csp Simulator is based on the presentation of Timed Csp in [4]. For a brief discussion of the tool architecture see [1, 2]. The semantical questions regarding simulating Timed Csp are discussed in [3].

Hoang Nga Nguyen; Markus Roggenbach

2012-01-01T23:59:59.000Z

349

Real time estimation of Bayesian networks  

Science Conference Proceedings (OSTI)

For real time evaluation of a Bayesian network when there is not sufficient time to obtain an exact solution, a guaranteed response time, approximate solution is required. It is shown that non traditional methods utilizing estimators based on an archive ...

Robert L. Welch

1996-08-01T23:59:59.000Z

350

Probabilistic timing analysis on conventional cache designs  

Science Conference Proceedings (OSTI)

Probabilistic timing analysis (PTA), a promising alternative to traditional worst-case execution time (WCET) analyses, enables pairing time bounds (named probabilistic WCET or pWCET) with an exceedance probability (e.g., 10-16), resulting ...

Leonidas Kosmidis, Charlie Curtsinger, Eduardo Quiñones, Jaume Abella, Emery Berger, Francisco J. Cazorla

2013-03-01T23:59:59.000Z

351

Nanosecond time resolved thermal emission measurements during...  

NLE Websites -- All DOE Office Websites (Extended Search)

Nanosecond time resolved thermal emission measurements during pulse excimer laser interaction with materials Title Nanosecond time resolved thermal emission measurements during...

352

Training Reciprocity Achieves Greater Consistency, Saves Time...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Training Reciprocity Achieves Greater Consistency, Saves Time and Money for Idaho, Other DOE Sites Training Reciprocity Achieves Greater Consistency, Saves Time and Money for...

353

Time Trends in Dutch Children's Mental Health.  

E-Print Network (OSTI)

??This study investigated time trends in Dutch children's and adolescent's mental health problems by comparing population samples from different time periods. From 1983 to 2003,… (more)

Tick, N.T.

2007-01-01T23:59:59.000Z

354

Spatial diversity in passive time reversal communications  

E-Print Network (OSTI)

Song et al. : Spatial diversity in passive time reversaland J. Ritcey, “Spatial diversity equalization applied toSpatial diversity in passive time reversal communications H.

2006-01-01T23:59:59.000Z

355

Undergraduate Program Time Limits and Work Schedules  

NLE Websites -- All DOE Office Websites (Extended Search)

Time Limits and Work Schedules Undergraduate Program Time Limits and Work Schedules Point your career towards LANL: work with the best minds on the planet in an inclusive...

356

Early Onset Cannabis Use and Progression to other Drug Use in a Sample of Dutch Twins  

E-Print Network (OSTI)

One of the most enduring controversies in drug research and policy concerns the extent to which early cannabis use may predispose to the use of other ‘‘hard’ ’ drugs such as cocaine and heroin (Kleiman, 1992; MacCoun, 1998). Stage theory posits that there is an invariant sequence in drug use with onset of use falling along a continuum with the licit drugs (tobacco, alcohol) being used before cannabis, which in turn precedes the use of other drugs such as cocaine and heroin (Kandel, 1975; Kandel and Faust, 1975). While such a sequence has been observed in numerous studies

Michael T. Lynskey; Jacqueline M. Vink; Dorret I. Boomsma; St Louis

2005-01-01T23:59:59.000Z

357

Timed CSP: A Retrospective Joel Ouaknine 1  

E-Print Network (OSTI)

APC 2005 Timed CSP: A Retrospective Jo¨el Ouaknine 1 Oxford University Computing Laboratory, UK Timed CSP, from its inception nearly twenty years ago to very recent semantical and algorithmic developments. Key words: Process algebra, Timed CSP. Timed CSP was first proposed in 1986 by Reed and Roscoe

Schneider, Steve

358

A review on time series data mining  

Science Conference Proceedings (OSTI)

Time series is an important class of temporal data objects and it can be easily obtained from scientific and financial applications. A time series is a collection of observations made chronologically. The nature of time series data includes: large in ... Keywords: Representation, Segmentation, Similarity measure, Time series data mining, Visualization

Tak-chung Fu

2011-02-01T23:59:59.000Z

359

Real-Time Airborne Particle Analyzer  

Geology, biology, and environmental science HAZMAT Weapons inspection : Real-time method for measuring elemental composition

360

Time Constant Estimates for Radiosonde Temperature Sensors  

Science Conference Proceedings (OSTI)

To correct time lag errors in radiosonde temperatures the sensor time constant has to be known. Time constants are not published for some widely used sensors and, in some cases, available time constants disagree. This study focuses on ML-405, ML-...

Marcel E. Tschudin; Steven R. Schroeder

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Multiple output timing and trigger generator  

SciTech Connect

In support of the development of a multiple stage pulse modulator at the Los Alamos National Laboratory, we have developed a first generation, multiple output timing and trigger generator. Exploiting Commercial Off The Shelf (COTS) Micro Controller Units (MCU's), the timing and trigger generator provides 32 independent outputs with a timing resolution of about 500 ns. The timing and trigger generator system is comprised of two MCU boards and a single PC. One of the MCU boards performs the functions of the timing and signal generation (the timing controller) while the second MCU board accepts commands from the PC and provides the timing instructions to the timing controller. The PC provides the user interface for adjusting the on and off timing for each of the output signals. This system provides 32 output or timing signals which can be pre-programmed to be in an on or off state for each of 64 time steps. The width or duration of each of the 64 time steps is programmable from 2 {micro}s to 2.5 ms with a minimum time resolution of 500 ns. The repetition rate of the programmed pulse train is only limited by the time duration of the programmed event. This paper describes the design and function of the timing and trigger generator system and software including test results and measurements.

Wheat, Robert M. [Los Alamos National Laboratory; Dale, Gregory E [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

362

SAMPLING AND MASS SPECTROMETRY APPROACHES FOR THE DETECTION OF DRUGS AND FOREIGN CONTAMINANTS IN BREATH FOR HOMELAND SECURITY APPLICATIONS  

Science Conference Proceedings (OSTI)

Homeland security relies heavily on analytical chemistry to identify suspicious materials and persons. Traditionally this role has focused on attribution, determining the type and origin of an explosive, for example. But as technology advances, analytical chemistry can and will play an important role in the prevention and preemption of terrorist attacks. More sensitive and selective detection techniques can allow suspicious materials and persons to be identified even before a final destructive product is made. The work presented herein focuses on the use of commercial and novel detection techniques for application to the prevention of terrorist activities. Although drugs are not commonly thought of when discussing terrorism, narcoterrorism has become a significant threat in the 21st century. The role of the drug trade in the funding of terrorist groups is prevalent; thus, reducing the trafficking of illegal drugs can play a role in the prevention of terrorism by cutting off much needed funding. To do so, sensitive, specific, and robust analytical equipment is needed to quickly identify a suspected drug sample no matter what matrix it is in. Single Particle Aerosol Mass Spectrometry (SPAMS) is a novel technique that has previously been applied to biological and chemical detection. The current work applies SPAMS to drug analysis, identifying the active ingredients in single component, multi-component, and multi-tablet drug samples in a relatively non-destructive manner. In order to do so, a sampling apparatus was created to allow particle generation from drug tablets with on-line introduction to the SPAMS instrument. Rules trees were developed to automate the identification of drug samples on a single particle basis. A novel analytical scheme was also developed to identify suspect individuals based on chemical signatures in human breath. Human breath was sampled using an RTube{trademark} and the trace volatile organic compounds (VOCs) were preconcentrated using solid phase microextraction (SPME) and identified using gas chromatography - mass spectrometry (GC-MS). Modifications to the sampling apparatus allowed for increased VOC collection efficiency, and reduced the time of sampling and analysis by over 25%. The VOCs are present in breath due to either endogenous production, or exposure to an external source through absorption, inhalation, or ingestion. Detection of these exogenous chemicals can provide information on the prior location and activities of the subject. Breath samples collected before and after exposure in a hardware store and nail salon were analyzed to investigate the prior location of a subject; breath samples collected before and after oral exposure to terpenes and terpenoid compounds, pseudoephedrine, and inhalation exposure to hexamine and other explosive related compounds were analyzed to investigate the prior activity of a subject. The elimination of such compounds from the body was also monitored. In application, this technique may provide an early warning system to identify persons of interest in the prevention and preemption stages of homeland security.

Martin, A N

2009-01-27T23:59:59.000Z

363

UNCORRECTEDPROOF Please cite this article in press as: Chen, H. et al., Nanonization strategies for poorly water-soluble drugs, Drug Discov Today (2010), doi:10.1016/j.drudis.2010.02.009  

E-Print Network (OSTI)

for poorly water-soluble drugs, Drug Discov Today (2010), doi:10.1016/j.drudis.2010.02.009 Drug Discovery Today Volume 00, Number 00 March 2010 REVIEWS Nanonization strategies for poorly water-soluble drugs and Technology, Wuhan 430074, China 3 CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety

Gao, Jinming

364

Time-of-flight radio location system  

DOE Patents (OSTI)

A bi-static radar configuration measures the direct time-of-flight of a transmitted RF pulse and is capable of measuring this time-of-flight with a jitter on the order of about one pico-second, or about 0.01 inch of free space distance for an electromagnetic pulse over a range of about one to ten feet. A transmitter transmits a sequence of electromagnetic pulses in response to a transmit timing signal, and a receiver samples the sequence of electromagnetic pulses with controlled timing in response to a receive timing signal, and generates a sample signal in response to the samples. A timing circuit supplies the transmit timing signal to the transmitter and supplies the receive timing signal to the receiver. The receive timing signal causes the receiver to sample the sequence of electromagnetic pulses such that the time between transmission of pulses in the sequence and sampling by the receiver sweeps over a range of delays. The receive timing signal sweeps over the range of delays in a sweep cycle such that pulses in the sequence are sampled at the pulse repetition rate, and with different delays in the range of delays to produce a sample signal representing magnitude of a received pulse in equivalent time. Automatic gain control circuitry in the receiver controls the magnitude of the equivalent time sample signal. A signal processor analyzes the sample signal to indicate the time-of-flight of the electromagnetic pulses in the sequence.

McEwan, Thomas E. (Livermore, CA)

1996-01-01T23:59:59.000Z

365

Time-of-flight radio location system  

DOE Patents (OSTI)

A bi-static radar configuration measures the direct time-of-flight of a transmitted RF pulse and is capable of measuring this time-of-flight with a jitter on the order of about one pico-second, or about 0.01 inch of free space distance for an electromagnetic pulse over a range of about one to ten feet. A transmitter transmits a sequence of electromagnetic pulses in response to a transmit timing signal, and a receiver samples the sequence of electromagnetic pulses with controlled timing in response to a receive timing signal, and generates a sample signal in response to the samples. A timing circuit supplies the transmit timing signal to the transmitter and supplies the receive timing signal to the receiver. The receive timing signal causes the receiver to sample the sequence of electromagnetic pulses such that the time between transmission of pulses in the sequence and sampling by the receiver sweeps over a range of delays. The receive timing signal sweeps over the range of delays in a sweep cycle such that pulses in the sequence are sampled at the pulse repetition rate, and with different delays in the range of delays to produce a sample signal representing magnitude of a received pulse in equivalent time. Automatic gain control circuitry in the receiver controls the magnitude of the equivalent time sample signal. A signal processor analyzes the sample signal to indicate the time-of-flight of the electromagnetic pulses in the sequence. 7 figs.

McEwan, T.E.

1996-04-23T23:59:59.000Z

366

Modeling data with multiple time dimensions  

Science Conference Proceedings (OSTI)

A large class of problems in time series analysis can be represented by a set of overlapping time series with different starting times. These time series may be treated as different probes of the same underlying process. Such probes may follow a characteristic ... Keywords: Dendrochronology, Douglas fir, Dual-time dynamics, El Malpais, Generalized additive models, Global climate change, Non-linear dynamics, Non-linear modeling, Pinon pine, Ponderosa pine, Portfolio forecasting, Retail lending, SETI@home, Scenario-based forecasting, Search for extraterrestrial intelligence, Time series, Tree rings

Joseph L. Breeden

2007-05-01T23:59:59.000Z

367

Climatological Time Series with Periodic Correlation  

Science Conference Proceedings (OSTI)

Many climatological time series display a periodic correlation structure. This paper examines three issues encountered when analyzing such time series: detection of periodic correlation, modeling periodic correlation, and trend estimation under ...

Robert Lund; Harry Hurd; Peter Bloomfield; Richard Smith

1995-11-01T23:59:59.000Z

368

Statistical Timing Analysis using Levelized Covariance Propagation  

Science Conference Proceedings (OSTI)

Variability in process parameters is making accurate timing analysis of nano-scale integrated circuits an extremely challenging task. In this paper, we propose a new algorithm for statistical timing analysis using Levelized Covariance Propagation (LCP). ...

Kunhyuk Kang; Bipul C. Paul; Kaushik Roy

2005-03-01T23:59:59.000Z

369

Apply for Beam Time | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Apply for Beam Time Apply for Beam Time NEXT PROPOSAL DEADLINE: March 7, 2014 @ 11:59 PM (Chicago time) Submit Proposal » SEE ALSO: Calendar: deadlines, run & review dates Help Page: frequently asked questions, tips for success, common errors, blank forms, instructions Review Criteria Sectors Directory: check CAT websites for info about managed beam time The Run 2014-2 proposal submission deadline is 11:59 p.m. (Chicago time) March 7, 2014. The system will open to accept proposals beginning December 20, 2013. NEW USERS: to avoid delays and to make the most of your time on site, read Become a User. You must register as a user and receive a badge number before submitting a proposal. About the Beam Time Request Process All beam time at the APS must be requested each cycle through the web-based

370

Statistical characterization of library timing performance  

Science Conference Proceedings (OSTI)

With the scaling of technology, the variability of timing performances of digital circuits is increasing. In this paper, we propose a first order analytical modeling of the standard deviations of basic CMOS cell timings. The proposed model is then used ...

V. Migairou; R. Wilson; S. Engels; N. Azemard; P. Maurine

2006-09-01T23:59:59.000Z

371

Phoenix: an epidemic approach to time reconstruction  

Science Conference Proceedings (OSTI)

Harsh deployment environments and uncertain run-time conditions create numerous challenges for postmortem time reconstruction methods. For example, motes often reboot and thus lose their clock state, considering that the majority of mote platforms lack ...

Jayant Gupchup; Douglas Carlson; R?zvan Mus?loiu-E.; Alex Szalay; Andreas Terzis

2010-02-01T23:59:59.000Z

372

Graduate Program Time Limits and Work Schedules  

NLE Websites -- All DOE Office Websites (Extended Search)

Time Limits and Work Schedules Graduate Program Time Limits and Work Schedules Point your career towards LANL: work with the best minds on the planet in an inclusive environment...

373

Space does not exist, so time can  

E-Print Network (OSTI)

It is often said that in general relativity time does not exist. This is because the Einstein equations generate motion in time that is a symmetry of the theory, not true time evolution. In quantum gravity, the timelessness of general relativity clashes with time in quantum theory and leads to the ``problem of time'' which, in its various forms, is the main obstacle to a successful quantum theory of gravity. I argue that the problem of time is a paradox, stemming from an unstated faulty premise. Our faulty assumption is that space is real. I propose that what does not fundamentally exist is not time but space, geometry and gravity. The quantum theory of gravity will be spaceless, not timeless. If we are willing to throw out space, we can keep time and the trade is worth it.

Fotini Markopoulou

2009-09-10T23:59:59.000Z

374

Precision Timing for Smart Grid Systems  

Science Conference Proceedings (OSTI)

... how new features and requirements for time synchronization can impact the performance of next-generation power distribution applications. ...

2013-04-29T23:59:59.000Z

375

A Hybrid Cellular Automaton Model of Solid Tumor Growth and Bioreductive Drug Transport  

Science Conference Proceedings (OSTI)

Bioreductive drugs are a class of hypoxia selective drugs that are designed to eradicate the hypoxic fraction of solid tumors. Their activity depends upon a number of biological and pharmacological factors and we used a mathematical modeling approach ... Keywords: Tumors,Biological system modeling,Drugs,Mathematical model,Electronic countermeasures,Computational modeling,Solids,microenvironment and Tirapazamine,Extra cellular matrix,Hypoxia,mathematical modeling

N. Kazmi; M. A. Hossain; R. M. Phillips

2012-11-01T23:59:59.000Z

376

Scalable Time Warp on Blue Gene Supercomputers  

Science Conference Proceedings (OSTI)

n this paper we illustrate scalable parallel performance for the TimeWarp synchronization protocol on the L and P variants of the IBM BlueGene supercomputer. Scalable Time Warp performance for models that communicate a large percentage of the event population ... Keywords: Time Warp, Blue Gene Supercomputer

David W. Bauer Jr.; Christopher D. Carothers; Akintayo Holder

2009-06-01T23:59:59.000Z

377

Shedding Light on Protein Drug Interactions | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Science Highlights Archives: 2013 | 2012 | 2011 | 2010 Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Shedding Light on Protein Drug Interactions JANUARY 23, 2008 Bookmark and Share In this e-coli cell, the proteins (shown in blue) crowd around ribosomes (purple). These regions have a high concentration of protein, typically greater than 30 percent, which limits the ensemble of states into which the proteins can bend themselves. Download hi-res image.) Proteins, the biological molecules that are involved in virtually every action of every organism, may themselves move in surprising ways, according to a recent study carried out at the Biophysics Collaborative Access Team x-ray beamline 18-ID at the Advanced Photon Source, a national user

378

Direct encapsulation of water-soluble drug into silica microcapsules for sustained release applications  

SciTech Connect

Direct encapsulation of water-soluble drug into silica microcapsules was facilely achieved by a sol-gel process of tetraethoxysilane (TEOS) in W/O emulsion with hydrochloric acid (HCl) aqueous solution containing Tween 80 and drug as well as cyclohexane solution containing Span 80. Two water-soluble drugs of gentamicin sulphate (GS) and salbutamol sulphate (SS) were chosen as model drugs. The characterization of drug encapsulated silica microcapsules by scanning electronic microscopy (SEM), FTIR, thermogravimetry (TG) and N{sub 2} adsorption-desorption analyses indicated that drug was successfully entrapped into silica microcapsules. The as-prepared silica microcapsules were uniform spherical particles with hollow structure, good dispersion and a size of 5-10 {mu}m, and had a specific surface area of about 306 m{sup 2}/g. UV-vis and thermogravimetry (TG) analyses were performed to determine the amount of drug encapsulated in the microcapsules. The BJH pore size distribution (PSD) of silica microcapsules before and after removing drug was examined. In vitro release behavior of drug in simulated body fluid (SBF) revealed that such system exhibited excellent sustained release properties.

Wang Jiexin; Wang Zhihui [Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Chen Jianfeng [Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029 (China)], E-mail: chenjf@mail.buct.edu.cn; Yun, Jimmy [Nanomaterials Technology Pte. Ltd., 28 Ayer Rajah Crescent 03-03, Singapore 139959 (Singapore)

2008-12-01T23:59:59.000Z

379

Bridging in vitro Dissolution Tests to in vivo Dissolution for Poorly Soluable Acidic Drugs.  

E-Print Network (OSTI)

??Developing meaningful in vitro dissolution methods is critical for evaluating the drug in vivo performance and providing a better standard for biowaiver tests. For Biopharmaceutical… (more)

Ping, Haili

2010-01-01T23:59:59.000Z

380

New drug development strategies: The differences between the initial plans and the final results.  

E-Print Network (OSTI)

??According to the literature, R&D investments in the pharmaceutical industry do not corresponds equally to the number of developed new drugs. The literature indicates that… (more)

Zoest, T.W. van

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Relationships among the personal fable, drug use and parental monitoring in adolescents and young adults.  

E-Print Network (OSTI)

??Relationships among the personal fable, drug use and parental monitoring in adolescents and young adults were tested in this study. Participants were 56 students, with… (more)

Liu, Xin, 1986 Feb. 2-

2011-01-01T23:59:59.000Z

382

The managed entry of new drugs into a National Health Service: a case study for Malta.  

E-Print Network (OSTI)

??The research question was to determine if it is possible to develop a systematic approach to the managed entry of new drugs into a National… (more)

Bonanno, Patricia Vella

2003-01-01T23:59:59.000Z

383

Anti-cancer actions in commonly used drugs: epidemiology led by laboratory science.  

E-Print Network (OSTI)

??Despite considerable research on cancer treatments and preventatives, poor outcomes in cancer patients are common. The vital search for effective cancer drugs often begins in… (more)

Walker, Alex J.

2011-01-01T23:59:59.000Z

384

JM to Revise DOE O 3792.3, Drug-Free Federal Workplace Testing Implementation Program  

Directives, Delegations, and Requirements

The subject directive provides requirements and responsibilities for the implementation of a workplace program to test for the use of illegal drugs to ...

2012-12-06T23:59:59.000Z

385

DOE O 3792.3 Chg 1, Drug-Free Federal Workplace Testing Implementation Program  

Directives, Delegations, and Requirements

The order provides guidance and policy for the administration, application and implementation of the DOE Drug-free Federal Workplace Plan and other regulations ...

1988-07-29T23:59:59.000Z

386

Time-of-flight radio location system  

DOE Patents (OSTI)

A bi-static radar configuration measures the direct time-of-flight of a transmitted RF pulse and is capable of measuring this time-of-flight with a jitter on the order of about one pico-second, or about 0.01 inch of free space distance for an electromagnetic pulse over a range of about one to ten feet. A transmitter transmits a sequence of electromagnetic pulses in response to a transmit timing signal, and a receiver samples the sequence of electromagnetic pulses with controlled timing in response to a receive timing signal, and generates a sample signal in response to the samples. A timing circuit supplies the transmit timing signal to the transmitter and supplies the receive timing signal to the receiver. The receive timing signal causes the receiver to sample the sequence of electromagnetic pulses such that the time between transmission of pulses in the sequence and sampling by the receiver sweeps over a range of delays. The receive timing signal sweeps over the range of delays in a sweep cycle such that pulses in the sequence are sampled at the pulse repetition rate, and with different delays in the range of delays to produce a sample signal representing magnitude of a received pulse in equivalent time. Automatic gain control circuitry in the receiver controls the magnitude of the equivalent time sample signal. A signal processor analyzes the sample signal to indicate the time-of-flight of the electromagnetic pulses in the sequence. The sample signal in equivalent time is passed through an envelope detection circuit, formed of an absolute value circuit followed by a low pass filter, to convert the sample signal to a unipolar signal to eliminate effects of antenna misorientation.

McEwan, Thomas E. (Livermore, CA)

1997-01-01T23:59:59.000Z

387

Time-of-flight radio location system  

DOE Patents (OSTI)

A bi-static radar configuration measures the direct time-of-flight of a transmitted RF pulse and is capable of measuring this time-of-flight with a jitter on the order of about one pico-second, or about 0.01 inch of free space distance for an electromagnetic pulse over a range of about one to ten feet. A transmitter transmits a sequence of electromagnetic pulses in response to a transmit timing signal, and a receiver samples the sequence of electromagnetic pulses with controlled timing in response to a receive timing signal, and generates a sample signal in response to the samples. A timing circuit supplies the transmit timing signal to the transmitter and supplies the receive timing signal to the receiver. The receive timing signal causes the receiver to sample the sequence of electromagnetic pulses such that the time between transmission of pulses in the sequence and sampling by the receiver sweeps over a range of delays. The receive timing signal sweeps over the range of delays in a sweep cycle such that pulses in the sequence are sampled at the pulse repetition rate, and with different delays in the range of delays to produce a sample signal representing magnitude of a received pulse in equivalent time. Automatic gain control circuitry in the receiver controls the magnitude of the equivalent time sample signal. A signal processor analyzes the sample signal to indicate the time-of-flight of the electromagnetic pulses in the sequence. The sample signal in equivalent time is passed through an envelope detection circuit, formed of an absolute value circuit followed by a low pass filter, to convert the sample signal to a unipolar signal to eliminate effects of antenna misorientation. 8 figs.

McEwan, T.E.

1997-08-26T23:59:59.000Z

388

High-Level Real-Time Concurrency  

E-Print Network (OSTI)

The primary goal of all real-time systems is predictability. Achieving this goal requires all levels of the system to be well de ned and have a xed worst-case execution time. These needs have resulted in the creation of overly restrictive commercial real-time systems providing only ad-hoc scheduling facilities and basic concurrent functionality. Ad-hoc scheduling makes developing, verifying, and maintaining a real-time system extremely dicult and time consuming. Basic concurrent functionality forces programmers to develop complex concurrent programs without the aid of high-level concurrency features.

Ashif S. Harji; C Ashif S. Harji

2000-01-01T23:59:59.000Z

389

Author's personal copy The time dependent vehicle routing problem with time windows  

E-Print Network (OSTI)

Author's personal copy The time dependent vehicle routing problem with time windows: Benchmark routing problems with hard or soft time windows without any alteration in its structure is presented of congested urban settings are proposed. Solution quality, time window pertur- bations, and computational time

Bertini, Robert L.

390

Time-Energy Measure for Quantum Processes  

E-Print Network (OSTI)

Quantum mechanics sets limits on how fast quantum processes can run given some system energy through time-energy uncertainty relations, and they imply that time and energy are tradeoff against each other. Thus, we propose to measure the time-energy as a single unit for quantum channels. We consider a time-energy measure for quantum channels and compute lower and upper bounds of it using the channel Kraus operators. For a special class of channels (which includes the depolarizing channel), we can obtain the exact value of the time-energy measure. One consequence of our result is that erasing quantum information requires $\\sqrt{(n+1)/n}$ times more time-energy resource than erasing classical information, where $n$ is the system dimension.

Chi-Hang Fred Fung; H. F. Chau

2013-05-24T23:59:59.000Z

391

Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery  

E-Print Network (OSTI)

Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what ...

Vukmirovic, Neda

2007-01-01T23:59:59.000Z

392

Sociodemographic and drug use characteristics, sex behaviors, and motivations for drug use among HIV- seronegative, heterosexual, methamphetamine users in San Diego, CA  

E-Print Network (OSTI)

users in San Francisco (the UFO Study). J Urban Health 2003;users in San Francisco (the UFO Study). J Urban Health 2003;Francisco from 1998 to 2004: the UFO Study. Drug Alcohol Rev

Cheng, Wei-Woon Susan

2009-01-01T23:59:59.000Z

393

Time set at Mon Aug 4 12:00:03 1997  

Science Conference Proceedings (OSTI)

... 13 JUL 93 / Commodities and Agriculture: China treats foot ... New era looks to mind drugs - In the second article of a series on drug research, Clive ...

394

Average Predictability Time. Part II: Seamless Diagnoses of Predictability on Multiple Time Scales  

Science Conference Proceedings (OSTI)

This paper proposes a new method for diagnosing predictability on multiple time scales without time averaging. The method finds components that maximize the average predictability time (APT) of a system, where APT is defined as the integral of ...

Timothy DelSole; Michael K. Tippett

2009-05-01T23:59:59.000Z

395

JAVA & Parallelism/Real-time systems  

E-Print Network (OSTI)

Windowing Toolkit (AWT) in a memory-efficient way. JAVA Application Environment (JAE) Support enables the same applets and applications to run on other servers or platforms running the JAVA Virtual Machine. CHAPTER 2 Embedded and Real-Time JAVA According to the designers at Sun Microsystems, is JAVA also suitable for Embedded or Real-Time systems. Before proceeding further it is worth trying to define the phrase `real-time system' more precisely. 2.1 Definition of a real-time system There are many interpretations of the exact nature of a real-time system; however, they all have in common the notion of response time, the time taken for the system to generate output from some associated input. The Oxford Dictionary of Computing [48] gives the following definition of a real-time system. A real-time system is... Any system in which the time at which output is produced is significant. This is usually because the input corresponds to some movement in the physical world, and the output ha...

D. F. Nooren

1998-01-01T23:59:59.000Z

396

Time and Tide Wait for No Diagram  

E-Print Network (OSTI)

Time plays an important role in some application domains, and can be quite difficult to deal with in diagrams. This is not only true for temporal uncertainty, but also for periodic events. We compare nine different representations that include a notion of time or that are mainly used for temporal information: Time Lines/LifeLines, AsbruView, Gantt- and PERT-Charts, Shinkansen timetables, Temporal Objects, Sets of Possible Occurrences (SOPOs), the Time Cube and Concentric Circles. Features of the different methods are presented and compared to other representations. This paper is meant to help the designer of a diagram or visualization who has to deal with time get an overview over different design ideas, and maybe get an inspiration for their own ideas. Keywords Information Visualization, Time in Problem Solving Methods, Knowledge Acquisition, Knowledge Engineering and Modeling Methodologies

Robert Kosara; Peter Messner; Silvia Miksch

2001-01-01T23:59:59.000Z

397

Property:Event/Time | Open Energy Information  

Open Energy Info (EERE)

Time Time Jump to: navigation, search Property Name Event/Time Property Type String Description The time an event occurs. For events which span an entire day, please use 'All Day'. When entering a specific time, please be sure to include the timezone information, for example: '2:45 PM MDT' or '10:00 AM GST'. Pages using the property "Event/Time" Showing 25 pages using this property. (previous 25) (next 25) A April Fool's Day + All Day + B Blane Harvey co-facilitating a session on use of climate decision making tools with CARE and Tearfund + 13:00-14:00 + Blane Harvey facilitating a lunchtime session on Indigenous Knowledge and Adaptation + 13:00-14:00 + Blane Harvey facilitating a lunchtime session on knowledge platforms and online communities of practice + 13:00-14:00 +

398

Reactor control rod timing system. [LMFBR  

DOE Patents (OSTI)

A fluid driven jet-edge whistle timing system is described for control rods of a nuclear reactor for producing real-time detection of the timing of each control rod in its scram operation. An important parameter in reactor safety, particularly for liquid metal fast breeder reactors (LMFBR), is the time deviation between the time the control rod is released and the time the rod actually reaches the down position. The whistle has a nearly pure tone signal with center frequency (above 100 kHz) far above the frequency band in which the energy of the background noise is concentrated. Each control rod can be fitted with a whistle with a different frequency so that there is no ambiguity in differentiating the signal from each control rod.

Wu, P.T.K.

1980-03-18T23:59:59.000Z

399

Time dependence of liquid-helium fluorescence  

SciTech Connect

The time dependence of extreme ultraviolet (EUV) fluorescence following an ionizing radiation event in liquid helium is observed and studied in the temperature range from 250 mK to 1.8 K. The fluorescence exhibits significant structure including a short ({approx}10 ns) strong initial pulse followed by single photons whose emission rate decays exponentially with a 1.6-{mu}s time constant. At an even longer time scale, the emission rate varies as '1/time' (inversely proportional to the time after the initial pulse). The intensity of the '1/time' component from {beta} particles is significantly weaker than those from {alpha} particles or neutron capture on {sup 3}He. It is also found that for {alpha} particles, the intensity of this component depends on the temperature of the superfluid helium. Proposed models describing the observed fluorescence are discussed.

McKinsey, D.N.; Brome, C.R.; Dzhosyuk, S.N.; Mattoni, C.E.H.; Yang, L.; Doyle, J.M. [Department of Physics, Harvard University, Cambridge, Massachusetts 02138 (United States); Golub, R.; Habicht, K.; Korobkina, E. [Hahn-Meitner Institut, Berlin-Wannsee (Germany); Huffman, P.R.; Thompson, A.K. [National Institute of Standards and Technology, Gaithersburg, Maryland 20899 (United States); Lamoreaux, S.K. [Los Alamos National Laboratory, Los Alamos, New Mexico 87544 (United States)

2003-06-01T23:59:59.000Z

400

Statistical criteria for characterizing irradiance time series.  

SciTech Connect

We propose and examine several statistical criteria for characterizing time series of solar irradiance. Time series of irradiance are used in analyses that seek to quantify the performance of photovoltaic (PV) power systems over time. Time series of irradiance are either measured or are simulated using models. Simulations of irradiance are often calibrated to or generated from statistics for observed irradiance and simulations are validated by comparing the simulation output to the observed irradiance. Criteria used in this comparison should derive from the context of the analyses in which the simulated irradiance is to be used. We examine three statistics that characterize time series and their use as criteria for comparing time series. We demonstrate these statistics using observed irradiance data recorded in August 2007 in Las Vegas, Nevada, and in June 2009 in Albuquerque, New Mexico.

Stein, Joshua S.; Ellis, Abraham; Hansen, Clifford W.

2010-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Tests of timing properties of silicon photomultipliers  

Science Conference Proceedings (OSTI)

Timing measurements of Silicon Photomultipliers (SiPM) [1] and [2] at the picosecond level were performed at Fermilab. The core timing resolution of the electronic measurement technique is approximately 2 ps. The single photoelectron time resolution (SPTR) was measured for the signals coming from the SiPM's. A SPTR of about one hundred picoseconds was obtained for SiPM's illuminated by laser pulses. The dependence of the SPTR on applied bias voltage and on the wavelength of the light was measured. A simple model is proposed to explain the difference in the SPTR for blue and red light. A time of flight system based on the SiPM's, with quartz Cherenkov radiators, was tested in a proton beam at Fermilab. The time resolution obtained is 35 ps per SiPM. Finally, requirements for the SiPM's temperature and bias voltage stability to maintain the time resolution are discussed.

Ronzhin, A.; Albrow, M.; /Fermilab; Byrum, K.; /Argonne; Demarteau, M.; Los, S.; /Fermilab; May, E.; /Argonne; Ramberg, A.; /Fermilab; Va'vra, J.; /SLAC; Zatserklyaniy, A.; /Puerto Rico U., Mayaguez

2010-03-01T23:59:59.000Z

402

Bell's Jump Process in Discrete Time  

E-Print Network (OSTI)

The jump process introduced by J. S. Bell in 1986, for defining a quantum field theory without observers, presupposes that space is discrete whereas time is continuous. In this letter, our interest is to find an analogous process in discrete time. We argue that a genuine analog does not exist, but provide examples of processes in discrete time that could be used as a replacement.

Jonathan Barrett; Matthew Leifer; Roderich Tumulka

2005-06-08T23:59:59.000Z

403

Time-parallel multiscale/multiphysics framework  

Science Conference Proceedings (OSTI)

We introduce the time-parallel compound wavelet matrix method (tpCWM) for modeling the temporal evolution of multiscale and multiphysics systems. The method couples time parallel (TP) and CWM methods operating at different spatial and temporal scales. ... Keywords: 02.00.00, 02.10.Jf, 05.10.-a, 46.15.-x, 47.70.Fw, Parallel-in-time, Wavelet-based multiscaling

G. Frantziskonis; K. Muralidharan; P. Deymier; S. Simunovic; P. Nukala; S. Pannala

2009-11-01T23:59:59.000Z

404

Runtime Monitoring of Timing Constraints in Distributed Real-Time Systems  

E-Print Network (OSTI)

. Embedded real-time systems often operate under strict timing and dependability constraints. To ensure responsiveness, these systems must be able to provide the expected services in a timely manner even in the presence of faults. In this paper, we describe a run-time environment for monitoring of timing constraints in distributed real-time systems. In particular, we focus on the problem of detecting violations of timing assertions in an environment in which the real-time tasks run on multiple processors, and timing constraints can be either inter-processor or intra-processor constraints. Constraint violations are detected at the earliest possible time by deriving and checking intermediate constraints from the user-specified constraints. If the violations must be detected as early as possible, then the problem of minimizing the number of messages to be exchanged between the processors becomes intractable. We characterize a sub-class of timing constraints that occur commonly in distribu...

Farnam Jahanian; Ragunathan Rajkumar; Sitaram C. V. Raju

1994-01-01T23:59:59.000Z

405

Sponsors : Daylighting The New York Times Building  

NLE Websites -- All DOE Office Websites (Extended Search)

researchindex.html In-kind cost-share The New York Times Company Advance Transformer Co. Lutron Electronics, Inc. MechoShade Systems, Inc. Siemens Building...

406

Special education teachers' personal time and money.  

E-Print Network (OSTI)

??Because of state and federal budget deficits. teachers are using thcir own time and rnoney to meet student nceds. This research seeks to determine the… (more)

Tewalt, Brandon

2009-01-01T23:59:59.000Z

407

Real Time Grid Reliability Management 2005  

E-Print Network (OSTI)

Environmental Research Energy Systems Integration Real Time2) integration with CA ISO energy management system (EMS);2) integration with CA ISO energy management system (EMS);

Eto, Joe

2008-01-01T23:59:59.000Z

408

Construction Timing and Expectations | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Construction Timing and Expectations Construction Timing and Expectations Construction Timing and Expectations October 16, 2013 - 5:07pm Addthis Creating a detailed construction schedule that allows all the project elements to be coordinated in a timely manner is fundamental to any successful construction project. The construction schedule should take into account that many tasks cannot be started before others are finished. It should also account for special schedule considerations related to renewable energy systems. Key elements of most new construction or major renovation projects include landscape, structural, architectural, mechanical, electrical, plumbing, communication systems, and renewable energy systems. Maintaining the highest quality of construction across all elements is fundamental to any

409

'Dead Time' Limits Quantum Cryptography Speeds  

Science Conference Proceedings (OSTI)

... Not only does dead time limit the transmission rate of a message ... effects and paralyzability in high-speed quantum key distribution, New Journal of ...

2012-06-08T23:59:59.000Z

410

Time Series Prediction Forecasting the Future and ...  

Science Conference Proceedings (OSTI)

Time Series Prediction Forecasting the Future and Understanding the Past Santa Fe Institute Proceedings on the Studies in the Sciences of ...

2012-10-01T23:59:59.000Z

411

NIST Time and Frequency Division 1993 - Technical ...  

Science Conference Proceedings (OSTI)

... can be reached with commercial red diode ... the time scale when building and remodelling ... American Geophysical Union meeting in San Francisco. ...

412

Commuting time geometry of ergodic Markov chains  

E-Print Network (OSTI)

We show how to map the states of an ergodic Markov chain to Euclidean space so that the squared distance between states is the expected commuting time. We find a minimax characterization of commuting times, and from this we get monotonicity of commuting times with respect to equilibrium transition rates. All of these results are familiar in the case of time-reversible chains, where techniques of classical electrical theory apply. In presenting these results, we take the opportunity to develop Markov chain theory in a `conformally correct' way

Doyle, Peter G

2011-01-01T23:59:59.000Z

413

Meykhana - The poetics of time and space.  

E-Print Network (OSTI)

??Right before the rhythmic, improvisational and poetic genre called meykhana was forbidden to practice in Soviet Azerbaijan, it bloomed for a short time in the… (more)

Zakariyya, Zulaim

2012-01-01T23:59:59.000Z

414

NIST Time Measurement and Analysis Service (TMAS)  

Science Conference Proceedings (OSTI)

... Analysis Service (TMAS) was designed to assist ... and calibrated time measurement system which includes ... easy-to-read instruction manual makes ...

2013-03-28T23:59:59.000Z

415

SIM Time and Frequency Working Group  

Science Conference Proceedings (OSTI)

... SIM Time and Frequency Metrology Course at INTI. Buenos Aires, Argentina (February 4th through February 7th, 2008). Schedule in PDF format. ...

416

SIM Time and Frequency Working Group  

Science Conference Proceedings (OSTI)

... file). Schedule and Slides from Time and Frequency Metrology Course in Buenos Aires, Argentina (2/4/08 to 02/07/08). Schedule ...

417

Time fractional development of quantum systems  

Science Conference Proceedings (OSTI)

In this study, the effect of time fractionalization on the development of quantum systems is taken under consideration by making use of fractional calculus. In this context, a Mittag-Leffler function is introduced as an important mathematical tool in the generalization of the evolution operator. In order to investigate the time fractional evolution of the quantum (nano) systems, time fractional forms of motion are obtained for a Schroedinger equation and a Heisenberg equation. As an application of the concomitant formalism, the wave functions, energy eigenvalues, and probability densities of the potential well and harmonic oscillator are time fractionally obtained via the fractional derivative order {alpha}, which is a measure of the fractality of time. In the case {alpha}=1, where time becomes homogenous and continuous, traditional physical conclusions are recovered. Since energy and time are conjugate to each other, the fractional derivative order {alpha} is relevant to time. It is understood that the fractionalization of time gives rise to energy fluctuations of the quantum (nano) systems.

Ertik, Hueseyin; Demirhan, Dogan; Sirin, Hueseyin; Bueyuekkilic, Fevzi [Department of Physics, Science Faculty, Ege University, Bornova, Izmir 35100 (Turkey)

2010-08-15T23:59:59.000Z

418

A misuse of time and energy .  

E-Print Network (OSTI)

??In this exegesis, A Misuse of Time and Energy, I set out a contextual framework for my practice-based sculptural project. I consider two flawed and… (more)

Blackburn, Nikolas Alexander

2013-01-01T23:59:59.000Z

419

TIME REVERSAL ACOUSTIC NONCONTACT SOURCE - Energy Innovation ...  

The present invention provides a flexible noncontact source of wave energy through the use of time reversal. In the preferred embodiment a ...

420

NIST Time and Frequency Division History  

Science Conference Proceedings (OSTI)

... of accurate measurements of mean solar time (from ... needs of the broadcast industry, NIST initiated ... Concurrent with the development of more recent ...

2010-10-05T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Multiplicative cascades and seismicity in natural time  

Science Conference Proceedings (OSTI)

Natural time chi enables the distinction of two origins of self-similarity, i.e., the process memory and the process increments infinite variance. Employing multiplicative cascades in natural time, the most probable value of the variance kappa{sub 1}(ident to-{sup 2}) is explicitly related with the parameter b of the Gutenberg-Richter law of randomly shuffled earthquake data. Moreover, the existence of temporal and magnitude correlations is studied in the original earthquake data. Magnitude correlations are larger for closer in time earthquakes, when the maximum interoccurrence time varies from half a day to 1 min.

Sarlis, N. V.; Skordas, E. S.; Varotsos, P. A. [Department of Physics, Solid State Section and Solid Earth Physics Institute, University of Athens, Panepistimiopolis, Zografos, 157 84 Athens (Greece)

2009-08-15T23:59:59.000Z

422

Four Time Periods - Energy Information Administration  

U.S. Energy Information Administration (EIA)

... we will be seeing a downward trend in differentials as time moves on. We expect the recent upturn in the light-heavy differentials to be ...

423

Publishers of Time and Frequency Software  

Science Conference Proceedings (OSTI)

... 1 Ace Software, X, Windows. Acrovista, X, Windows. Apple Computer, X, Macintosh. Atom Time, X, Windows. Beagle Software, X, X, Windows. ...

2013-03-08T23:59:59.000Z

424

Time synchronization for underwater acoustic sensor networks.  

E-Print Network (OSTI)

??The unique properties of underwater acoustic communications, such as large and time-varying propagation, low and range dependent bandwidth, and adverse operating environment make the synchronization… (more)

Khandoker, Tarik-Ul Islam

2012-01-01T23:59:59.000Z

425

Raspberry derived mesoporous carbon-tubules and fixed-bed adsorption of pharmaceutical drugs  

E-Print Network (OSTI)

Raspberry derived mesoporous carbon-tubules and fixed-bed adsorption of pharmaceutical drugs Shashi 210023, China c Laboratory of Green Chemistry, Lappeenranta University of Technology, Sammonkatu 12 Department, University of Florida, Gainesville, FL 32611-0290, USA 1. Introduction Pharmaceutical drugs (PD

Ma, Lena

426

Building a generic graph-based descriptor set for use in drug discovery  

Science Conference Proceedings (OSTI)

The ability to predict drug activity from molecular structure is an important field of research both in academia and in the pharmaceutical industry. Raw 3D structure data is not in a form suitable for identifying properties using machine learning so ... Keywords: QSAR, drug discovery, machine learning, molecular graphs, simple paths

Phillip Lock; Nicolas Le Mercier; Jiuyong Li; Markus Stumptner

2009-12-01T23:59:59.000Z

427

Mechanism Based Anticancer Drugs that Degrade Sp Transcription Factors  

E-Print Network (OSTI)

Curcumin is the active component of tumeric, and this polyphenolic compound has been extensively investigated as an anticancer drug that modulates multiple pathways and genes. We demonstrated that curcumin inhibited 253JB-V and KU7 bladder cancer cell growth, and this was accompanied by induction of apoptosis and decreased expression of the proapoptotic protein survivin and the angiogenic proteins vascular endothelial growth factor (VEGF) and VEGF receptor 1 (VEGFR1). Since expression of survivin, VEGF and VEGFR1 are dependent on specificity protein (Sp) transcription factors, we also investigated the effects of curcumin on downregulation of Sp protein expression as an underlying mechanism for the apoptotic and antiangiogenic activity of this compound. Curcumin decreases expression of Sp1, Sp3 and Sp4 in blader cancer cells indicating that the cancer chemotherapeutic activity of curcumin is due, in part, to decreased expression of Sp transcription factors and Sp-dependent genes. Betulinic acid (BA) and curcumin are phytochemical anticancer agents, and we hypothesized that both compounds decrease EGFR expression in bladder cancer through downregulation of specificity protein (Sp) transcription factors. BA and curcumin decreased expression of EGFR, Sp1, Sp3, Sp4 and Sp-dependent proteins in 253JB-V and KU7 cells; EGFR was also decreased in cells transfected with a cocktail (iSp) containing small inhibitory RNAs for Sp1, Sp3 and Sp4 showing that EGFR is an Sp-regulated gene. Methyl 2-cyano-3,11-dioxo-18?-olean-1,12- dien-30-oate (CDODA-Me) is a synthetic triterpenoid derived from glycyrrhetinic acid which inhibits proliferation of KU7 and 253JB-V bladder cancer cells. CDODA-Me also decreased expression of specificity protein-1 (Sp1), Sp3 and Sp4 transcription factors. Similar results were observed for a structurally-related triterpenoid, methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me), which is currently in clinical trials for treatment of leukemia. Celastrol, a naturally occurring triterpenoid acid from an ivy-like vine exhibits anticancer activity against bladder cancer cells. Celastrol decreased cell proliferation, induced apoptosis and decreased expression of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and several Sp-dependent genes like Fibroblast growth factor receptor 3 (FGFR3). In vivo studies using KU7 cells as xenografts showed that celastrol represents novel class of anticancer drugs that acts, in part, through targeting downregulation of Sp transcription factors.

Chadalapaka, Gayathri

2009-12-01T23:59:59.000Z

428

ORIGINAL PAPER Barriers to Pharmacy-Based Syringe Purchase Among Injection Drug Users in Tijuana, Mexico: A Mixed Methods Study  

E-Print Network (OSTI)

Ó The Author(s) 2010. This article is published with open access at Springerlink.com Abstract Injection drug users (IDUs) may be denied purchase of sterile syringes even where purchase without a prescription is legal. This study examined barriers to overthe-counter (OTC) syringe purchase among IDUs in Tijuana, Mexico. A quantitative survey and subsequent focus groups were used to quantify barriers to purchase, identify their correlates and provide in-depth exploration of syringe purchase experiences. Of 627 IDUs, 81 % purchased a syringe in the past 6 months and 16 % were refused or overcharged. Factors independently associated with refusal/overcharging were homelessness, receptive syringe sharing, [5 uses per syringe, and number of lifetime abscesses. Few pharmacies sold syringes to IDUs, who adapted by limiting purchase attempts to pharmacies known to sell syringes consistently. Failed purchases occurred when drug withdrawal required purchase at unusual times or locations, often following release from jail. IDUs reported syringe sharing, syringe reuse, and searching through unsecured medical waste for syringes in response to failed purchase attempts. Interventions to expand OTC syringe sales to IDUs, particularly near detention facilities, will facilitate safer injection practices.

Robin A. Pollini; Remedios Lozada; Manuel Gallardo; Perth Rosen; Alicia Vera Arm; O Macias; R. A. Pollini; P. Rosen A. Vera; L. A. Palinkas; S. A. Strathdee; R. Lozada; M. Gallardo; A. Macias; L. A. Palinkas

2010-01-01T23:59:59.000Z

429

Memorandum, Drug Testing at DOE - September 14, 2007 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Memorandum, Drug Testing at DOE - September 14, 2007 Memorandum, Drug Testing at DOE - September 14, 2007 Memorandum, Drug Testing at DOE - September 14, 2007 As established in his memorandum dated September 14, 2007, the Secretary has determined that applicants for, and holders of, a Department of Energy (DOE) Q or L access authorization (security clearance) will be in Testing Designated Positions (TDP) as specified in DOE Order 3792.3, Drug-Free Federal Workplace Testing Implementation Program, for Federal employees, and Title 10, Code of Federal Regulations, Part 707, Workplace Substance Abuse Programs at DOE Sites, for contractor employees. Accordingly, individuals who are either in, or are selected for, a TDP are subject to applicant, random and for cause testing. Additionally, the Secretary has determined individuals who have used illegal drugs within 12

430

DEVELOPMENT AND EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM FOR LORNOXICAM  

E-Print Network (OSTI)

Aim of the present work was to develop and evaluate a solid self-emulsifying drug delivery system (SEDDS) for oral poorly water-soluble drug lornoxicam. The liquid (SEDDS) consisted of capmul MCM as oil phase, tween 20 as surfactant and PEG 400 as co-surfactant. Oil, surfactant and co-surfactant were selected on the basis of solubilisation capacity of drug and emulsification ability of surfactant and co-surfactants. The formulations were optimized by constructing the pseudo-ternary phase diagram. The liquid formulation was solidified by laboratory scale spray dryer, using Aerosil 200 as solid carrier. The solid SEDDS shows greater drug release thus, solid SEDDS improves the oral bioavailability and may provide the useful solid dosage form for oral poorly water soluble drugs.

V. V. Chopade; P. D. Chaudhari

2013-01-01T23:59:59.000Z

431

Nordic Journal of Computing 10(2003), 135. TIMED CSP = CLOSED TIMED -AUTOMATA  

E-Print Network (OSTI)

Nordic Journal of Computing 10(2003), 1­35. TIMED CSP = CLOSED TIMED -AUTOMATA JO¨EL OUAKNINE CSP which significantly increase expressiveness. As a result, we are able to capture some of the most of the finite-state fragment of this augmented version of Timed CSP as that of closed timed -automata

Ouaknine, Joël

432

Nordic Journal of Computing 10(2003), 1--35. TIMED CSP = CLOSED TIMED #AUTOMATA  

E-Print Network (OSTI)

Nordic Journal of Computing 10(2003), 1--35. TIMED CSP = CLOSED TIMED #­AUTOMATA JO Ë? EL OUAKNINE CSP which significantly increase expressiveness. As a result, we are able to capture some of the most of the finite­state fragment of this augmented version of Timed CSP as that of closed timed #­automata

Ouaknine, Joël

433

Continuous-time nonlinear model predictive control of time-delayed Wiener-type systems  

Science Conference Proceedings (OSTI)

This paper deals with a novel method of continuous-time model predictive control for nonlinear time-delayed systems. The problems regarding time delays are solved by incorporating delayed and undelayed model outputs in the control-law derivation. Nonlinear-mapping ... Keywords: Wiener-type model, continuous system, nonlinear predictive control, time-delayed system

Simon Oblak; Igor Škrjanc

2006-02-01T23:59:59.000Z

434

Fractal analysis of time varying data  

DOE Patents (OSTI)

Characteristics of time varying data, such as an electrical signal, are analyzed by converting the data from a temporal domain into a spatial domain pattern. Fractal analysis is performed on the spatial domain pattern, thereby producing a fractal dimension D.sub.F. The fractal dimension indicates the regularity of the time varying data.

Vo-Dinh, Tuan (Knoxville, TN); Sadana, Ajit (Oxford, MS)

2002-01-01T23:59:59.000Z

435

Iterative Time Reversal with Tunable Convergence  

E-Print Network (OSTI)

We propose and test an iterative technique for improving the temporal focusing of a time reversal mirror. A single amplification parameter is introduced to tune the convergence of the iteration. The tunable iterative technique is validated by tests on an experimental electromagnetic time reversal mirror, as well as on a novel numerical model.

Biniyam Tesfaye Taddese; Thomas M. Antonsen; Edward Ott; Steven M. Anlage

2011-07-07T23:59:59.000Z

436

Real-time var control by SCADA  

SciTech Connect

This paper outlines the operation and advantages of the SCADA capacitor control called CAPCON, developed by the Virginia Electric and Power Company (Virginia Power). CAPCON is used to control vars system-wide by switching substation capacitor banks based on real-time var and voltage data instead of the traditional time clock method.

Girotti, T.B.; Tweed, N.B.; Houser, N.R. (Virginia Power Co., Richmond, VA (USA))

1990-02-01T23:59:59.000Z

437

Practical reporting times for environmental samples  

Science Conference Proceedings (OSTI)

Preanalytical holding times for environmental samples are specified because chemical and physical characteristics may change between sampling and chemical analysis. For example, the Federal Register prescribes a preanalytical holding time of 14 days for volatile organic compounds in soil stored at 4{degrees}C. The American Society for Testing Materials (ASTM) uses a more technical definition that the preanalytical holding time is the day when the analyte concentration for an environmental sample falls below the lower 99% confidence interval on the analyte concentration at day zero. This study reviews various holding time definitions and suggest a new preanalytical holding time approach using acceptable error rates for measuring an environmental analyte. This practical reporting time (PRT) approach has been applied to nineteen volatile organic compounds and four explosives in three environmental soil samples. A PRT nomograph of error rates has been developed to estimate the consequences of missing a preanalytical holding time. This nomograph can be applied to a large class of analytes with concentrations that decay linearly or exponentially with time regardless of sample matrices and storage conditions.

Bayne, C.K.; Schmoyer, D.D.; Jenkins, R.A.

1993-02-01T23:59:59.000Z

438

Predicting time series with advanced hybrid systems  

Science Conference Proceedings (OSTI)

Autogressive moving average (ARMA) has been widely used to model processes that generate linear time-series. Recent research activities in forecasting with artificial neutral networks (ANNs) suggest that ANNs can be a promising alternative to the traditional ... Keywords: ARMA models, fuzzy system, hybrid system, neutral networks, time series

O. Valenzuela; I. Rojas; F. Rojas; H. Pomares; J. Gonzalez; L. J. Herrera; A. Guillen

2005-12-01T23:59:59.000Z

439

Gravity in Complex Hermitian Space-Time  

E-Print Network (OSTI)

A generalized theory unifying gravity with electromagnetism was proposed by Einstein in 1945. He considered a Hermitian metric on a real space-time. In this work we review Einstein's idea and generalize it further to consider gravity in a complex Hermitian space-time.

Ali H. Chamseddine

2006-10-09T23:59:59.000Z

440

Efficient forecasting for hierarchical time series  

Science Conference Proceedings (OSTI)

Forecasting is used as the basis for business planning in many application areas such as energy, sales and traffic management. Time series data used in these areas is often hierarchically organized and thus, aggregated along the hierarchy levels based ... Keywords: forecasting, hierarchies, optimization, time series

Lars Dannecker; Robert Lorenz; Philipp Rösch; Wolfgang Lehner; Gregor Hackenbroich

2013-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Tritium Time Series from Ocean Station P  

Science Conference Proceedings (OSTI)

We present time series of tritium (3H) concentrations at varying depths in the water column at Ocean Station P(50°N, 145°W) in the northeast Pacific. Measurements started in the fall of 1974, at the time of the GEOSECS mapping of the North ...

A. E. Gargett; G. Ostlund; C. S. Wong

1986-10-01T23:59:59.000Z

442

Integrated method for chaotic time series analysis  

DOE Patents (OSTI)

Methods and apparatus for automatically detecting differences between similar but different states in a nonlinear process monitor nonlinear data. Steps include: acquiring the data; digitizing the data; obtaining nonlinear measures of the data via chaotic time series analysis; obtaining time serial trends in the nonlinear measures; and determining by comparison whether differences between similar but different states are indicated.

Hively, Lee M. (Philadelphia, TN); Ng, Esmond G. (Concord, TN)

1998-01-01T23:59:59.000Z

443

Is the notion of time really fundamental?  

E-Print Network (OSTI)

From the Physics point of view, time is now best described through General Relativity, as part of space-time which is a dynamical object encoding gravity. Time possesses also some intrinsic irreversibility due to thermodynamics, quantum mechanical effects... This irreversibility can look puzzling since time-like loops (and hence time machines) can appear in General Relativity (for example in the Goedel universe, a solution of Einstein's equations). We take this apparent discrepancy as a warning bell pointing to us that time as we understand it, might not be fundamental and that whatever theory, lying beyond General Relativity, may not include time as we know it as a fundamental structure. We propose therefore, following the philosophy of analog models of gravity, that time and gravity might not be fundamental per se, but only emergent features. We illustrate our proposal using a toy-model where we show how the Lorentzian signature and Nordstroem gravity (a diffeomorphisms invariant scalar gravity theory) can emerge from a timeless non-dynamical space.

Florian Girelli; Stefano Liberati; Lorenzo Sindoni

2009-03-27T23:59:59.000Z

444

Airport Gate Scheduling with Time Windows  

Science Conference Proceedings (OSTI)

In contrast to the existing airport gate assignment studies where flight have fixed schedules, we consider the more realistic situation where flight arrival and departure times can change. Although we minimize walking distances (or travel time) in our ... Keywords: aircraft gate scheduling, memetic algorithm, tabu search

A. Lim; B. Rodrigues; Y. Zhu

2005-09-01T23:59:59.000Z

445

Time series forecasting with Qubit Neural Networks  

Science Conference Proceedings (OSTI)

This paper proposes a quantum learning scheme approach for time series forecasting, through the application of the new non-standard Qubit Neural Network (QNN) model. The QNN description was adapted in this work in order to resemble classical Artificial ... Keywords: artificial intelligence, artificial neural networks, quantum computing, qubit neural networks, time series forecasting

Carlos R. B. Azevedo; Tiago A. E. Ferreira

2007-08-01T23:59:59.000Z

446

Computing Needs Time Edward A. Lee  

E-Print Network (OSTI)

, and Toyota. #12;Computing Needs Time Edward A. Lee UC Berkeley eal@eecs.berkeley.edu February 18, 2009, and Toyota. 1 #12;E. A. Lee, Berkeley Computing Needs Time "It seems to have a computer; need I say more."1

447

EnergyPlus Run Time Analysis  

SciTech Connect

EnergyPlus is a new generation building performance simulation program offering many new modeling capabilities and more accurate performance calculations integrating building components in sub-hourly time steps. However, EnergyPlus runs much slower than the current generation simulation programs. This has become a major barrier to its widespread adoption by the industry. This paper analyzed EnergyPlus run time from comprehensive perspectives to identify key issues and challenges of speeding up EnergyPlus: studying the historical trends of EnergyPlus run time based on the advancement of computers and code improvements to EnergyPlus, comparing EnergyPlus with DOE-2 to understand and quantify the run time differences, identifying key simulation settings and model features that have significant impacts on run time, and performing code profiling to identify which EnergyPlus subroutines consume the most amount of run time. This paper provides recommendations to improve EnergyPlus run time from the modeler?s perspective and adequate computing platforms. Suggestions of software code and architecture changes to improve EnergyPlus run time based on the code profiling results are also discussed.

Hong, Tianzhen; Buhl, Fred; Haves, Philip

2008-09-20T23:59:59.000Z

448

Integrated method for chaotic time series analysis  

DOE Patents (OSTI)

Methods and apparatus for automatically detecting differences between similar but different states in a nonlinear process monitor nonlinear data are disclosed. Steps include: acquiring the data; digitizing the data; obtaining nonlinear measures of the data via chaotic time series analysis; obtaining time serial trends in the nonlinear measures; and determining by comparison whether differences between similar but different states are indicated. 8 figs.

Hively, L.M.; Ng, E.G.

1998-09-29T23:59:59.000Z

449

FAST: Frequency-aware static timing analysis  

Science Conference Proceedings (OSTI)

Energy is a valuable resource in embedded systems as the lifetime of many such systems is constrained by their battery capacity. Recent advances in processor design have added support for dynamic frequency/voltage scaling (DVS) for saving energy. Recent ... Keywords: Real-time systems, dynamic voltage scaling, scheduling, worst-case execution time analysis

Kiran Seth; Aravindh Anantaraman; Frank Mueller; Eric Rotenberg

2006-02-01T23:59:59.000Z

450

It's Time to ACT | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

It's Time to ACT It's Time to ACT It's Time to ACT May 25, 2011 - 10:32am Addthis John Lippert In my November 29, 2010 and my February 15, 2011 blog postings, I described some tools and strategies based on behavioral psychology that some companies and organizations are using to encourage people to use less energy and purchase clean energy. Here's another one. I was reading an article the other day in which University of Nevada, Reno, psychologist Steven Hayes gave his explanation of why we Americans are so reluctant to adjust our thermostats. He believes our culture has conditioned us to avoid all discomfort. In other words, we believe that we should feel good all the time. The funny thing is that I heard multiple times essentially the same message at religious services I attended. The common thread in these messages and

451

Fermilab | Fermilab Time and Labor | Launch  

NLE Websites -- All DOE Office Websites (Extended Search)

Go to FTL timecard Click here to create and submit your timecard on the Fermilab Time and Labor system. Alternate System Login This link uses html only and may work on your mobile device. It is provided for ease of use only. If it doesn't work for you, please use the other link. Fermilab Time and Labor All employees use a single, standard system to report their time and effort electronically. Log in to the system here. This has modernized our time and labor reporting system and helps Fermilab comply with DOE requirements. Use this page to access tools that will help you use the Fermilab Time & Labor electronic timecard. You can login to your timecard, access training materials and documentation and ensure that your browser has the settings and software it needs to access the system.

452

It's Time to ACT | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

It's Time to ACT It's Time to ACT It's Time to ACT May 25, 2011 - 10:32am Addthis John Lippert In my November 29, 2010 and my February 15, 2011 blog postings, I described some tools and strategies based on behavioral psychology that some companies and organizations are using to encourage people to use less energy and purchase clean energy. Here's another one. I was reading an article the other day in which University of Nevada, Reno, psychologist Steven Hayes gave his explanation of why we Americans are so reluctant to adjust our thermostats. He believes our culture has conditioned us to avoid all discomfort. In other words, we believe that we should feel good all the time. The funny thing is that I heard multiple times essentially the same message at religious services I attended. The common thread in these messages and

453

Changes in risk perception over time  

SciTech Connect

The focus of this paper is on changes in perceptions of the risks associated with nuclear waste management over time. In particular, we are interested in the kinds of change that take place when the management programs, and those who are charged with implementing them, are subject to intensive public debate over an extended period of time. We are undertaken an over-time study of perceived risks in Colorado and New Mexico by implementing sequential random household surveys in each state, timed at six month intervals. This study employs three of these surveys, spanning the period from summer, 1990 to summer, 1991. Using these data, we examine the dynamics that may underlie variations in perceived risks over time. In particular, our analysis is focused on changes in the roles played by (1) basic political orientations (i.e. political ideology) and (2) trust in those who advocate conflicting policy positions.

Gomez, L.S. [Sandia National Labs., Albuquerque, NM (United States); Jenkins-Smith, H.C.; Miller, K.W. [New Mexico Univ., Albuquerque, NM (United States)

1992-01-01T23:59:59.000Z

454

Time-Domain Electromagnetics | Open Energy Information  

Open Energy Info (EERE)

Time-Domain Electromagnetics Time-Domain Electromagnetics Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Technique: Time-Domain Electromagnetics Details Activities (10) Areas (10) Regions (0) NEPA(0) Exploration Technique Information Exploration Group: Geophysical Techniques Exploration Sub Group: Electrical Techniques Parent Exploration Technique: Electromagnetic Sounding Techniques Information Provided by Technique Lithology: Detection of rock units or geological features with contrasting apparent resistivity. Stratigraphic/Structural: Structural information may be inferred from TDEM data. Hydrological: Hydrological information such as depth to groundwater table may be determined. Thermal: Extent of hydrothermal alteration mineralogy may be inferred. Cost Information

455

Real time sensor for therapeutic radiation delivery  

DOE Patents (OSTI)

The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body. 14 figs.

Bliss, M.; Craig, R.A.; Reeder, P.L.

1998-01-06T23:59:59.000Z

456

Real time sensor for therapeutic radiation delivery  

DOE Patents (OSTI)

The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body.

Bliss, Mary (West Richland, WA); Craig, Richard A. (West Richland, WA); Reeder, Paul L. (Richland, WA)

1998-01-01T23:59:59.000Z

457

Proper Time Flow Equation for Gravity  

E-Print Network (OSTI)

We analyze a proper time renormalization group equation for Quantum Einstein Gravity in the Einstein-Hilbert truncation and compare its predictions to those of the conceptually different exact renormalization group equation of the effective average action. We employ a smooth infrared regulator of a special type which is known to give rise to extremely precise critical exponents in scalar theories. We find perfect consistency between the proper time and the average action renormalization group equations. In particular the proper time equation, too, predicts the existence of a non-Gaussian fixed point as it is necessary for the conjectured nonperturbative renormalizability of Quantum Einstein Gravity.

Bonanno, A

2005-01-01T23:59:59.000Z

458

Nuclear dynamics in time-dependent picture  

E-Print Network (OSTI)

Using the time-dependent theory of quantum mechanics, we investigate nuclear electric dipole responses. The time evolution of a wave function is explicitly calculated in the coordinate-space representation. The particle continuum is treated with the absorbing boundary condition. Calculated time-dependent quantities are transformed into those of familiar energy representation. We apply the method to a three-body model for 11Li and to the mean-field model for 22O, then discuss properties of E1 response.

Takashi Nakatsukasa; Makoto Ito; Kazuhiro Yabana

2006-10-19T23:59:59.000Z

459

Graduate Program Time Limits and Work Schedules  

NLE Websites -- All DOE Office Websites (Extended Search)

Time Limits and Work Schedules Time Limits and Work Schedules Graduate Program Time Limits and Work Schedules Point your career towards LANL: work with the best minds on the planet in an inclusive environment that is rich in intellectual vitality and opportunities for growth. Contact Student Programs (505) 665-8899 Email Time Limits The length of participation in the graduate program is limited as follows: With a bachelor's pursuing a master's degree: 4 years With a bachelor's pursuing a PhD: 7 years With a master's pursuing a second master's degree: 2 years With a master's pursuing a PhD: 4 years With a master's pursuing a master's and PhD in a new field: 6 years Students may remain in the GRA program for up to three months after receiving their PhD. Work schedules Year-round students Students participating in the MBA program, post-baccalaureate appointments,

460

Space-Time Insight | Open Energy Information  

Open Energy Info (EERE)

Space-Time Insight Space-Time Insight Jump to: navigation, search Name Space-Time Insight Address 45680 Northport Loop East Place Fremont, California Zip 94538 Sector Efficiency Product SpaceTime Awareness Server Year founded 2008 Number of employees 11-50 Website http://www.spacetimeinsight.co Coordinates 37.4923832°, -121.9532879° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":37.4923832,"lon":-121.9532879,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Property:Real-Time | Open Energy Information  

Open Energy Info (EERE)

Real-Time Real-Time Jump to: navigation, search Property Name Real-Time Property Type String Pages using the property "Real-Time" Showing 25 pages using this property. (previous 25) (next 25) 1 1.5-ft Wave Flume Facility + No + 10-ft Wave Flume Facility + No + 11-ft Wave Flume Facility + No + 2 2-ft Flume Facility + No + 3 3-ft Wave Flume Facility + No + 5 5-ft Wave Flume Facility + No + 6 6-ft Wave Flume Facility + No + A Alden Large Flume + Yes + Alden Small Flume + Yes + Alden Tow Tank + Yes + Alden Wave Basin + Yes + B Breakwater Research Facility + No + Bucknell Hydraulic Flume + No + C Carderock 2-ft Variable Pressure Cavitation Water Tunnel + No + Carderock 3-ft Variable Pressure Cavitation Water Tunnel + No + Carderock Circulating Water Channel + No +

462

Unraveling life four letters at a time  

NLE Websites -- All DOE Office Websites (Extended Search)

Unraveling life four letters at a time Unraveling life four letters at a time 1663 Los Alamos science and technology magazine Latest Issue:November 2013 All Issues » submit Unraveling life four letters at a time Major advances in sequencing since the official end of the Human Genome Project are fueling a revolution in genomics research. November 25, 2013 Unraveling life four letters at a time Reading the genetic code of life keeps getting faster and cheaper, bringing more and more new discoveries within reach. The genomics revolution that came after the Human Genome Project The Human Genome Project officially ended in 2003, but the 10 years since have seen dramatic improvements in genomics technology and discovery. New, rapid sequencing machines provide high throughput conversion of genetic material (DNA or RNA) into data to be arranged into its proper order by a

463

Energy drift in reversible time integration  

E-Print Network (OSTI)

Energy drift is commonly observed in reversible integrations of systems of molecular dynamics. We show that this drift can be modelled as a diffusion and that the typical energy error after time T is O(?T).

R I McLachlan; M Perlmutter

2004-01-01T23:59:59.000Z

464

Fun with sub-linear time algorithms  

Science Conference Proceedings (OSTI)

Provided that one is willing to use randomness and to tolerate an approximate answer, many computational problems admit ultrafast algorithms that run in less than linear time in the length of the input. In many interesting cases, even algorithms that ...

Luca Trevisan

2007-06-01T23:59:59.000Z

465

Undergraduate Program Time Limits and Work Schedules  

NLE Websites -- All DOE Office Websites (Extended Search)

Time Limits and Work Schedules Time Limits and Work Schedules Undergraduate Program Time Limits and Work Schedules Point your career towards LANL: work with the best minds on the planet in an inclusive environment that is rich in intellectual vitality and opportunities for growth. Contact Student Programs (505) 665-8899 Email Time limits The length of participation in the undergraduate program is limited to a maximum of six years for students pursuing a bachelor's degree and three years for students pursuing an associate's degree. Work schedules Year-round students Students participating in some special undergraduate programs, post-baccalaureate appointments, post-master's appointments, and GRA students working on a thesis or dissertation are excluded from the 30-hour per week work restriction.

466

NSLS User Access | Requesting Beam Time  

NLE Websites -- All DOE Office Websites (Extended Search)

Requesting Beam Time Requesting Beam Time Use one of the following options depending on your research: General User Proposal General User proposals are peer reviewed for scientific merit by a Proposal Review Panel (PRP). General User proposals compete for beamtime with other General User Proposals based on scientific merit. Once the original proposal and beam time request is reviewed and rated in the PASS System, additional beam time requests can be submitted against the original proposal for its lifetime, a period of up to six cycles (two years). Data taken during experiments associated with a General User proposal is considered to be in the public domain. There is no charge for General User beamtime. Rapid Access Rapid Access proposals are a subset of General User proposals available for

467

Estimates of Characteristic Times for Precipitation Scavenging  

Science Conference Proceedings (OSTI)

We address the problem of using climatological data to estimate residence times in the atmosphere of particles subjected to precipitation scavenging. Basic parameters are the scavenging coefficient ?, the rainfall intensity R and the length of ...

Henning Rodhe; Jan Grandell

1981-02-01T23:59:59.000Z

468

Casimir forces in the time domain: Applications  

E-Print Network (OSTI)

Our previous article [Phys. Rev. A 80, 012115 (2009)] introduced a method to compute Casimir forces in arbitrary geometries and for arbitrary materials that was based on a finite-difference time-domain (FDTD) scheme. In ...

Johnson, Steven G.

469

Real Time Energy Pricing Web Services Implementation  

NLE Websites -- All DOE Office Websites (Extended Search)

Real Time Energy Pricing Web Services Implementation Speaker(s): Jim Boch Kim McCaffrey Robert Nawy Date: December 15, 2010 - 12:00pm Location: 90-3122 Seminar HostPoint of...

470

Space–Time Correlations of Lightning Distributions  

Science Conference Proceedings (OSTI)

Lightning location data are used to calculate the autocorrelation function of lightning distributions, which is a function of distances and time intervals between the single lightning events. This function is utilized for the characterization of ...

Ulli Finke

1999-08-01T23:59:59.000Z

471

Time Scales of Land Surface Hydrology  

Science Conference Proceedings (OSTI)

This paper intends to investigate the time scales of land surface hydrology and enhance the understanding of the hydrological cycle between the atmosphere, vegetation, and soil. A three-layer model for land surface hydrology is developed to study ...

Aihui Wang; Xubin Zeng; Samuel S. P. Shen; Qing-Cun Zeng; Robert E. Dickinson

2006-10-01T23:59:59.000Z

472

Virtual stationary timed automata for mobile networks  

E-Print Network (OSTI)

In this thesis, we formally define a programming abstraction for mobile networks called the Virtual Stationary Automata programming layer, consisting of real mobile clients, virtual timed I/O automata called virtual ...

Nolte, Tina Ann, 1979-

2009-01-01T23:59:59.000Z

473

The Aging Workforce and Paid Time Off  

E-Print Network (OSTI)

The Aging Workforce and Paid Time Off Draft 07/08/09 Gilliana matter of the workforce aging as the population ages. Thephysical changes with aging that can affect performance. 10

Lester, Gillian

2009-01-01T23:59:59.000Z

474

Real-time rendering systems in 2010  

Science Conference Proceedings (OSTI)

We present a case for future real-time rendering systems that support non-physically-correct global illumination techniques by using ray tracing visibility algorithms, by integrating scene management with rendering, and by executing on general-purpose ...

William R. Mark; Donald Fussell

2005-07-01T23:59:59.000Z

475

It's About Time: Investing in Transportation to  

E-Print Network (OSTI)

MARCH 2011 It's About Time: Investing in Transportation to Keep Texas Economically Competitive #12 of Contents Preface 1 The Challenge Facing Texans 3 Texas Transportation Action Principles 6 Texas' Deteriorating Transportation System: Background and Measurement 8 Baseline Scenario: Unacceptable Conditions

476

Thermodynamics and time-directional invariance  

E-Print Network (OSTI)

Time directions are not invariant in conventional thermodynamics. We broadly follow ideas of Ludwig Boltzmann and investigate implications of postulating time-directional invariance in thermodynamics. In this investigation, we require that thermodynamic descriptions are not changed under time reversal accompanied by replacement of matter by antimatter (i.e. CPT-invariant thermodynamics). The matter and antimatter are defined as thermodynamic concepts without detailing their physical structure. Our analysis stays within the limits of conceptual thermodynamics and leads to effective negative temperatures, to thermodynamic restrictions on time travel and to inherent antagonism of matter and antimatter. This antagonism is purely thermodynamic; it explains the difficulty in achieving thermodynamic equilibrium between matter and antimatter and does not postulate their mutual annihilation on contact. We believe that the conclusions of this work can be of interest not only for people researching or teaching thermodyn...

Klimenko, A Y

2012-01-01T23:59:59.000Z

477

book review: A book for our time  

E-Print Network (OSTI)

important thing in this book isn’t actually written down innews and update ISSN 1948-6596 book reviewA book for our time Spatial Conservation Prioritization —

Grenyer, Richard

2009-01-01T23:59:59.000Z

478

Advective Time Lags in Box Models  

Science Conference Proceedings (OSTI)

A box model of the thermohaline circulation with mixed boundary conditions in which advective processes are incorporated via an explicit time delay mechanism is considered. The pipes that connect the subtropical and subpolar boxes have a finite ...

Douglas A. Kurtze; Juan M. Restrepo

2001-07-01T23:59:59.000Z

479

Real-Time Mesoscale Prediction on workstations  

Science Conference Proceedings (OSTI)

Experience in performing real-time mesoscale numerical prediction forecasts using the Regional Atmospheric Modeling System (RAMS) over Colorado for a winter season on high-performance workstations is summarized. Performance evaluation is done for ...

William R. Cotton; Gregory Thompson; Paul W. Mieike Jr.

1994-03-01T23:59:59.000Z

480

Real time PCR measurement by fluorescence anisotropy  

E-Print Network (OSTI)

Real-time polymerase chain reaction (PCR) is the gold-standard for quantitation in both mutation and gene expression analyses. Already this technique has found valuable clinical application in disease diagnosis and progression ...

Crane, Bryan Lee, 1976-

2005-01-01T23:59:59.000Z

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481

Near Real-Time Push Middleware  

E-Print Network (OSTI)

Architecture.. 102 System Trial .. 109 Chapter 6 Electric vehicle smart charging and vehicle-to-gridSmart Grid, to address deficiencies in existing research, and to advance the state of the art in near real-time push architectures.

Mal, Siddhartha Byron

2012-01-01T23:59:59.000Z

482

REAL TIME SYSTEM OPERATIONS 2006-2007  

Science Conference Proceedings (OSTI)

The Real Time System Operations (RTSO) 2006-2007 project focused on two parallel technical tasks: (1) Real-Time Applications of Phasors for Monitoring, Alarming and Control; and (2) Real-Time Voltage Security Assessment (RTVSA) Prototype Tool. The overall goal of the phasor applications project was to accelerate adoption and foster greater use of new, more accurate, time-synchronized phasor measurements by conducting research and prototyping applications on California ISO's phasor platform - Real-Time Dynamics Monitoring System (RTDMS) -- that provide previously unavailable information on the dynamic stability of the grid. Feasibility assessment studies were conducted on potential application of this technology for small-signal stability monitoring, validating/improving existing stability nomograms, conducting frequency response analysis, and obtaining real-time sensitivity information on key metrics to assess grid stress. Based on study findings, prototype applications for real-time visualization and alarming, small-signal stability monitoring, measurement based sensitivity analysis and frequency response assessment were developed, factory- and field-tested at the California ISO and at BPA. The goal of the RTVSA project was to provide California ISO with a prototype voltage security assessment tool that runs in real time within California ISO?s new reliability and congestion management system. CERTS conducted a technical assessment of appropriate algorithms, developed a prototype incorporating state-of-art algorithms (such as the continuation power flow, direct method, boundary orbiting method, and hyperplanes) into a framework most suitable for an operations environment. Based on study findings, a functional specification was prepared, which the California ISO has since used to procure a production-quality tool that is now a part of a suite of advanced computational tools that is used by California ISO for reliability and congestion management.

Eto, Joseph H.; Parashar, Manu; Lewis, Nancy Jo

2008-08-15T23:59:59.000Z

483

Polynomial Time Algorithms for Minimum Energy Scheduling  

E-Print Network (OSTI)

The aim of power management policies is to reduce the amount of energy consumed by computer systems while maintaining satisfactory level of performance. One common method for saving energy is to simply suspend the system during the idle times. No energy is consumed in the suspend mode. However, the process of waking up the system itself requires a certain fixed amount of energy, and thus suspending the system is beneficial only if the idle time is long enough to compensate for this additional energy expenditure. In the specific problem studied in the paper, we have a set of jobs with release times and deadlines that need to be executed on a single processor. Preemptions are allowed. The processor requires energy L to be woken up and, when it is on, it uses one unit of energy per one unit of time. It has been an open problem whether a schedule minimizing the overall energy consumption can be computed in polynomial time. We solve this problem in positive, by providing an O(n^5)-time algorithm. In addition we pr...