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Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Drug Retention Times  

SciTech Connect (OSTI)

The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

Center for Human Reliability Studies

2007-05-01T23:59:59.000Z

2

Drug Retention Times  

SciTech Connect (OSTI)

The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

Center for Human Reliability Studies

2007-05-01T23:59:59.000Z

3

SciTech Connect: Drug Retention Times  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administrationcontroller systems controllerAdditiveBetatronAerogelDistances fromUsage SystemDrug

4

Soil Water Retention Measurements Using a Combined Tensiometer-Coiled Time Domain Reflectometry Probe  

E-Print Network [OSTI]

Soil Water Retention Measurements Using a Combined Tensiometer-Coiled Time Domain Reflectometry al., 1975; Arya et al.,that can be used to determine soil water retention curves in both 1975; Royer of a standard tensiometer. The combined tensiometer-coiled TDR probe was con- of soil water retention curves

Wildenschild, Dorthe

5

Use of rare earth elements as external markers for mean retention time measurements in ruminants  

E-Print Network [OSTI]

Review Use of rare earth elements as external markers for mean retention time measurements -- The present review deals with the utilisation of rare earth (RE) elements as particulate markers for ruminant earth / retention time / feedstuff / methodology / ruminant Résumé -- Utilisation des terres rares comme

Paris-Sud XI, Université de

6

Influence of addition order and contact time on thorium (IV) retention by hematite in the presence  

E-Print Network [OSTI]

1 Influence of addition order and contact time on thorium (IV) retention by hematite.reiller@cea.fr The influence of addition order and contact time in the system hematite (-Fe2O3) ­ humic acid (HA) ­ thorium (IV) was studied in batch experiments. Thorium (IV) is considered here as a chemical analogue of other actinides

Paris-Sud XI, Université de

7

The retention time of inorganic mercury in the brain A systematic review of the evidence  

SciTech Connect (OSTI)

Reports from human case studies indicate a half-life for inorganic mercury in the brain in the order of yearscontradicting older radioisotope studies that estimated half-lives in the order of weeks to months in duration. This study systematically reviews available evidence on the retention time of inorganic mercury in humans and primates to better understand this conflicting evidence. A broad search strategy was used to capture 16,539 abstracts on the Pubmed database. Abstracts were screened to include only study types containing relevant information. 131 studies of interest were identified. Only 1 primate study made a numeric estimate for the half-life of inorganic mercury (227540 days). Eighteen human mercury poisoning cases were followed up long term including autopsy. Brain inorganic mercury concentrations at death were consistent with a half-life of several years or longer. 5 radionucleotide studies were found, one of which estimated head half-life (21 days). This estimate has sometimes been misinterpreted to be equivalent to brain half-lifewhich ignores several confounding factors including limited radioactive half-life and radioactive decay from surrounding tissues including circulating blood. No autopsy cohort study estimated a half-life for inorganic mercury, although some noted bioaccumulation of brain mercury with age. Modelling studies provided some extreme estimates (69 days vs 22 years). Estimates from modelling studies appear sensitive to model assumptions, however predications based on a long half-life (27.4 years) are consistent with autopsy findings. In summary, shorter estimates of half-life are not supported by evidence from animal studies, human case studies, or modelling studies based on appropriate assumptions. Evidence from such studies point to a half-life of inorganic mercury in human brains of several years to several decades. This finding carries important implications for pharmcokinetic modelling of mercury and potentially for the regulatory toxicology of mercury.

Rooney, James P.K., E-mail: jrooney@rcsi.ie

2014-02-01T23:59:59.000Z

8

The effect of solids retention time on tertiary ozonation and carbon adsorption of petrochemical wastewaters  

E-Print Network [OSTI]

. Biological treatment of wastewater has been used since the turn of the century, and while its application has grown in complexity since that time, the fundamental biological reaction mechanisms have remained unchanged. Most important... organic carbon from the wastewater by conversion into microbial cells, or some other desirable form. Biological waste treatment is usually intended for the removal of organic matter, but certain other contaminants are also removed, For example...

Buys, Ronald Earl

1980-01-01T23:59:59.000Z

9

West Virginia University -Main Campus Student Retention and Graduation Rates  

E-Print Network [OSTI]

West Virginia University - Main Campus Student Retention and Graduation Rates First-Time, Full ---------------------------------------------------------------------Continuation Rates and Cumulative Graduation Rates

Mohaghegh, Shahab

10

Understanding the drivers of value creation for biopharmaceuticals around the time of drug launch  

E-Print Network [OSTI]

The purpose of this research is to investigate potential strategic variables that executives at small to mid-sized biopharmaceutical companies should consider during the period of a drug launch. Bringing a product to market ...

You, Sung Min

2012-01-01T23:59:59.000Z

11

Real-time electrochemical monitoring of drug release from therapeutic nanoparticles Laura Mora a,c  

E-Print Network [OSTI]

both academic and industrial investigators in the past two decades because of its many favorable, liposomes, solid lipid NPs, polymeric NPs, dendrimers, silica NPs, and nanoemulsions [3,4]. For all desirable for obtaining reliable assessment of the drug release kinetics. While several analytical

Zhang, Liangfang

12

Drug delivery by organ-specific immunoliposomes  

SciTech Connect (OSTI)

Monoclonal antibodies highly specific to the mouse pulmonary endothelial cells were conjugated to liposomes. The resulting immunoliposomes showed high levels of lung accumulation when injected intravenously into mice. Optimal target binding and retention were achieved if the lipid composition included ganglioside GM{sub 1} to reduce the uptake of immunoliposomes by the reticuloendothelial system. Details of the construction and optimization of these organ-specific immunoliposomes are reviewed. The drug delivery potential of this novel liposome system was demonstrated in an experimental pulmonary metastasis model. Immunoliposomes containing a lipophilic prodrug of deoxyfluorouridine effectively prolonged the survival time of the tumor-bearing mice. This and other therapeutic applications of the immunoliposomes are discussed. 25 refs., 5 figs.

Maruyama, Kazuo; Mori, Atsuhide; Hunag, Leaf (Tennessee Univ., Knoxville, TN (USA). Dept. of Biochemistry); Kennel, S.J. (Oak Ridge National Lab., TN (USA))

1990-01-01T23:59:59.000Z

13

Oxygen plasma immersion ion implantation treatment to enhance data retention of tungsten nanocrystal nonvolatile memory  

SciTech Connect (OSTI)

Data retention characteristics of tungsten nanocrystal (W-NC) memory devices using an oxygen plasma immersion ion implantation (PIII) treatment are investigated. With an increase of oxygen PIII bias voltage and treatment time, the capacitancevoltage hysteresis memory window is increased but the data retention characteristics become degraded. High-resolution transmission electron microscopy images show that this poor data retention is a result of plasma damage on the tunneling oxide layer, which can be prevented by lowering the bias voltage to 7?kV. In addition, by using the elevated temperature retention measurement technique, the effective charge trapping level of the WO{sub 3} film surrounding the W-NCs can be extracted. This measurement reveals that a higher oxygen PIII bias voltage and treatment time induces more shallow traps within the WO{sub 3} film, degrading the retention behavior of the W-NC memory.

Wang, Jer-Chyi, E-mail: jcwang@mail.cgu.edu.tw; Chang, Wei-Cheng; Lai, Chao-Sung, E-mail: cslai@mail.cgu.edu.tw [Department of Electronic Engineering, Chang Gung University, Kweishan 333, Taoyuan, Taiwan (China); Chang, Li-Chun [Department of Material Engineering and Center for Thin Film Technologies and Applications, Ming Chi University of Technology, Taishan 24301, New Taipei City, Taiwan (China); Ai, Chi-Fong; Tsai, Wen-Fa [Institute of Nuclear Energy Research, Atomic Energy Council, Longtan 325, Taoyuan, Taiwan (China)

2014-03-15T23:59:59.000Z

14

Technetium Retention During LAW Vitrification  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power.pdf11-161-LNGInternational EnergyCommitteeRenewable1234 OFTechnetium Retention During LAW

15

Workforce Retention Work Group | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

skilled workforce retention; health, safety and productivity; and especially preventive health care. Inform and support improvement andor development of wellness, fitness, and...

16

Radionuclide Retention in Concrete Wasteforms  

SciTech Connect (OSTI)

Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how wasteform performance is affected by the full range of environmental conditions within the disposal facility; the process of wasteform aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of wasteform aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the wasteforms come in contact with groundwater. Data collected throughout the course of this work will be used to quantify the efficacy of concrete wasteforms, similar to those used in the disposal of LLW and MLLW, for the immobilization of key radionuclides (i.e., uranium, technetium, and iodine). Data collected will also be used to quantify the physical and chemical properties of the concrete affecting radionuclide retention.

Wellman, Dawn M.; Jansik, Danielle P.; Golovich, Elizabeth C.; Cordova, Elsa A.

2012-09-24T23:59:59.000Z

17

Radionuclide Retention in Concrete Wasteforms  

SciTech Connect (OSTI)

Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how wasteform performance is affected by the full range of environmental conditions within the disposal facility; the process of wasteform aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of wasteform aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the wasteforms come in contact with groundwater. The information present in the report provides data that (1) measures the effect of concrete wasteform properties likely to influence radionuclide migration; and (2) quantifies the rate of carbonation of concrete materials in a simulated vadose zone repository.

Bovaird, Chase C.; Jansik, Danielle P.; Wellman, Dawn M.; Wood, Marcus I.

2011-09-30T23:59:59.000Z

18

Segmented vs conventional numerals: legibility and long term retention  

E-Print Network [OSTI]

the environmental chamber. Sub jects The subjects were thirty male students between the ages of 1g and 27 from the Industrial Engineering department at Texas A&M University. Subjects were divided into three groups of 10. Procedure Exposure time and number... December 1971 Ma]or Subject: Industrial Engineering SEGMENTED VS CONVENTIONAL NUMERALS: LEGIBILITY AND LONG TERM RETENTION A Thesis STEVE EDGAR HILL Approved as to style and content by: Elias Chairman of Committee) r. A. W. ortham (Head...

Hill, Steve Edgar

1971-01-01T23:59:59.000Z

19

Residential Refrigerator Recycling Ninth Year Retention Study  

E-Print Network [OSTI]

Residential Refrigerator Recycling Ninth Year Retention Study Study ID Nos. 546B, 563 Prepared RECYCLING PROGRAMS Study ID Nos. 546B and 563 Prepared for Southern California Edison Rosemead, California

20

Deuterium Retention in NSTX with Lithium Conditioning  

SciTech Connect (OSTI)

High (? 90%) deuterium retention was observed in NSTX gas balance measurements both withand without lithiumization of the carbon plasma facing components. The gas retained in ohmic discharges was measured by comparing the vessel pressure rise after a discharge to that of a gasonly pulse with the pumping valves closed. For neutral beam heated discharges the gas input and gas pumped by the NB cryopanels were tracked. The discharges were followed by outgassing of deuterium that reduced the retention. The relationship between retention and surface chemistry was explored with a new plasma-material interface probe connected to an in-vacuo surface science station that exposed four material samples to the plasma. XPS and TDS analysis showed that the binding of D atoms is fundamentally changed by lithium - in particular atoms are weakly bonded in regions near lithium atoms bound to either oxygen or the carbon matrix.

C.H. Skinner, J.P. Allain, W. Blanchard, H.W. Kugel, R. Maingi, L. Roquemore, V. Soukhanovskii, C.N. Taylor

2010-06-02T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

High temperature ceramic composition for hydrogen retention  

DOE Patents [OSTI]

A ceramic coating for H retention in fuel elements is described. The coating has relatively low thermal neutron cross section, is not readily reduced by H at 1500 deg F, is adherent to the fuel element base metal, and is stable at reactor operating temperatures. (JRD)

Webb, R.W.

1974-01-01T23:59:59.000Z

22

Recruiting, Retention & Advancement Recruiting: Searching for Excellence and  

E-Print Network [OSTI]

#12;Recruiting, Retention & Advancement Recruiting: Searching for Excellence and Diversity: A Workshop for Faculty Search Committee Chairs Retention: Enhancing Department Climate: A Chair's Role Advancement: Senior women meetings #12;Recruiting 3-part workshops for chairs of hiring committees Based

Sheridan, Jennifer

23

Influence of plasticizer molecular weight on plasticizer retention in PVC geomembranes  

E-Print Network [OSTI]

PROOFS Influence of plasticizer molecular weight on plasticizer retention in PVC geomembranes T. D, accepted 31 October 2004 ABSTRACT: Plasticizers are used to make PVC flexible so it can be used as a geomembrane. Plasticizers can migrate from PVC geomembranes over time because of contact with air, liquid, and

24

Radionuclide Retention in Concrete Wasteforms - FY13  

SciTech Connect (OSTI)

Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how wasteform performance is affected by the full range of environmental conditions within the disposal facility; the process of wasteform aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of wasteform aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the wasteforms come in contact with groundwater. Data collected throughout the course of this work will be used to quantify the efficacy of concrete wasteforms, similar to those used in the disposal of low-level waste and mixed low-level waste, for the immobilization of key radionuclides (i.e., uranium, technetium, and iodine). Data collected will also be used to quantify the physical and chemical properties of the concrete affecting radionuclide retention.

Snyder, Michelle MV; Golovich, Elizabeth C.; Wellman, Dawn M.; Crum, Jarrod V.; Lapierre, Robert; Dage, Denomy C.; Parker, Kent E.; Cordova, Elsa A.

2013-10-15T23:59:59.000Z

25

Radionuclide Retention in Concrete Waste Forms  

SciTech Connect (OSTI)

Assessing long-term performance of Category 3 waste cement grouts for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e., sorption or precipitation); the mechanism of contaminant release; the significance of contaminant release pathways; how waste form performance is affected by the full range of environmental conditions within the disposal facility; the process of waste form aging under conditions that are representative of processes occurring in response to changing environmental conditions within the disposal facility; the effect of waste form aging on chemical, physical, and radiological properties; and the associated impact on contaminant release. This knowledge will enable accurate prediction of radionuclide fate when the waste forms come in contact with groundwater. The information presented in the report provides data that 1) quantify radionuclide retention within concrete waste form materials similar to those used to encapsulate waste in the Low-Level Waste Burial Grounds (LLBG); 2) measure the effect of concrete waste form properties likely to influence radionuclide migration; and 3) quantify the stability of uranium-bearing solid phases of limited solubility in concrete.

Mattigod, Shas V.; Bovaird, Chase C.; Wellman, Dawn M.; Wood, Marcus I.

2010-09-30T23:59:59.000Z

26

Retention of Halogens in Waste Glass  

SciTech Connect (OSTI)

In spite of their potential roles as melting rate accelerators and foam breakers, halogens are generally viewed as troublesome components for glass processing. Of five halogens, F, Cl, Br, I, and At, all but At may occur in nuclear waste. A nuclear waste feed may contain up to 10 g of F, 4 g of Cl, and ?100 mg of Br and I per kg of glass. The main concern is halogen volatility, producing hazardous fumes and particulates, and the radioactive iodine 129 isotope of 1.7x10^7-year half life. Because F and Cl are soluble in oxide glasses and tend to precipitate on cooling, they can be retained in the waste glass in the form of dissolved constituents or as dispersed crystalline inclusions. This report compiles known halogen-retention data in both high-level waste (HLW) and low-activity waste (LAW) glasses. Because of its radioactivity, the main focus is on I. Available data on F and Cl were compiled for comparison. Though Br is present in nuclear wastes, it is usually ignored; no data on Br retention were found.

Hrma, Pavel R.

2010-05-01T23:59:59.000Z

27

Microfabricated injectable drug delivery system  

DOE Patents [OSTI]

A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

2002-01-01T23:59:59.000Z

28

Volatile Species Retention During Metallic Fuel Casting  

SciTech Connect (OSTI)

Metallic nuclear fuels are candidate transmutation fuel forms for advanced fuel cycles. Through the operation of the Experimental Breeder Reactor II metallic nuclear fuels have been shown to be robust and easily manufactured. However, concerns have been raised concerning loss of americium during the casting process because of its high vapor pressure. In order to address these concerns a gaseous diffusion model was developed and a series of experiments using both manganese and samarium as surrogates for americium were conducted. The modeling results showed that volatility losses can be controlled to essentially no losses with a modest overpressure. Experimental results also showed volatile species retention down to no detectable losses through overpressure, although the loss values varied from the model results the same trend was seen. Bases on these results it is very probably that americium losses through volatility can be controlled to no detectable losses through application of a modest overpressure during casting.

Randall S. Fielding; Douglas L. Proter

2013-10-01T23:59:59.000Z

29

207-A retention basins system design description  

SciTech Connect (OSTI)

The 242-A Evaporator is a waste treatment facility designed to reduce liquid waste volumes currently stored in the Hanford Area double shell Waste Storage Tanks. The evaporator uses evaporative concentration to achieve this volume reduction, returning the concentrated slurry to the double-shell tanks for storage. The process effluent is transferred to various retention/treatment facilities for eventual release to the environment. The process utilizes an evaporator vessel and various supporting systems for heating, evaporating, and condensing low-heat-generating liquid waste produced it the Hanford Site. The process reduces the total volume of the liquid waste requiring storage in a double shell tank, making it more manageable for current storage as well as for future treatment and disposal. The main components of the 242-A Evaporator are the Reboiler, Vapor-Liquid Separator, Recirculation Pump and Pump Loop, Slurry System, Condenser System, Steam Jet Vacuum System, Condensate Collection Tank, and Ion Exchange System.

Wahlquist, R.A.

1994-09-29T23:59:59.000Z

30

E-Print Network 3.0 - advanced in-vessel retention Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

L. (2008). Advances in modelling hysteretic water retention curve... COMPACTED CLAYEY SOILS: MODELLING THE WATER RETENTION BEHAVIOUR Della Vecchia, G. (dellavecchia......

31

Formation and retention of methane in coal  

SciTech Connect (OSTI)

The formation and retention of methane in coalbeds was studied for ten Utah coal samples, one Colorado coal sample and eight coal samples from the Argonne Premium Coal Sample Bank.Methane gas content of the Utah and Colorado coals varied from zero to 9 cm{sup 3}/g. The Utah coals were all high volatile bituminous coals. The Colorado coal was a gassy medium volatile bituminous coal. The Argonne coals cover a range or rank from lignite to low volatile bituminous coal and were used to determine the effect of rank in laboratory studies. The methane content of six selected Utah coal seams and the Colorado coal seam was measured in situ using a special sample collection device and a bubble desorbometer. Coal samples were collected at each measurement site for laboratory analysis. The cleat and joint system was evaluated for the coal and surrounding rocks and geological conditions were noted. Permeability measurements were performed on selected samples and all samples were analyzed for proximate and ultimate analysis, petrographic analysis, {sup 13}C NMR dipolar-dephasing spectroscopy, and density analysis. The observed methane adsorption behavior was correlated with the chemical structure and physical properties of the coals.

Hucka, V.J.; Bodily, D.M.; Huang, H.

1992-05-15T23:59:59.000Z

32

Study of liquid retention in fixed-bed reactors with upward flow of gas and liquid  

SciTech Connect (OSTI)

A literature survey of the measurement techniques for the determination of liquid retention in cocurrent upward gas and liquid flow in fixed-bed reactors is presented. A number of these techniques were used in this work in columns of different diameters (Dc = 0.05 m, 0.10 m, and 0.15 m). Porous alumina particles of two different diameters (dp = 0.002 m and 0.0028 m) with both nonfoaming (water, cyclohexane, heptane, and propanol) and foaming liquids (kerosene, LCO, and diesel fuel) have been investigated. The gas used was either air or N[sub 2]. The methods investigated include volumetry, gravimetry, gammametry, and determination of residence-time distribution by tracer technique. A simple correlation for the prediction of total gas and liquid retention for bubble and pulsed flow is proposed and verified.

Yang, X.L.; Euzen, J.P. (Inst. Francais du Petrole, Vernaison (France)); Wild, G. (Lab. des Sciences du Genie Chimique, Nancy (France))

1993-01-01T23:59:59.000Z

33

Bubble retention in synthetic sludge: Testing of alternative gas retention apparatus  

SciTech Connect (OSTI)

Several of the underground storage tanks currently used to store waste at Hanford have been placed on the Flammable Gas Watch List, because the waste is either known or suspected to generate, store, and episodically release flammable gases. The objective of this experimental study is to develop a method to measure gas bubble retention in simulated tank waste and in diluted simulant. The method and apparatus should (1) allow for reasonably rapid experiments, (2) minimize sample disturbance, and (3) provide realistic bubble nucleation and growth. The scope of this experimental study is to build an apparatus for measuring gas retention in simulated waste and to design the apparatus to be compatible with future testing on actual waste. The approach employed for creating bubbles in sludge involves dissolving a soluble gas into the supernatant liquid at an elevated pressure, recirculating the liquid containing the dissolved gas through the sludge, then reducing the pressure to allow bubbles to nucleate and grow. Results have been obtained for ammonia as the soluble gas and SY1-SIM-91A, a chemically representative simulated tank waste. In addition, proof-of-principle experiments were conducted with both ammonia and CO{sub 2} as soluble gases and sludge composed of 90-micron glass beads. Results are described.

Rassat, S.D.; Gauglitz, P.A.

1995-07-01T23:59:59.000Z

34

OFWAR: Reducing SSD Response Time Using On-Demand Fast-Write-and-Rewrite  

E-Print Network [OSTI]

OFWAR: Reducing SSD Response Time Using On-Demand Fast-Write-and-Rewrite Qi Wu and Tong Zhang to degrade SSD response time, we speed up memory programming at the penalty of shorter data retention time the average SSD response time by up to 52.3%. Index Terms--Solid-state drive, data retention, workload

Zhang, Tong

35

Oral Drug Absorption  

E-Print Network [OSTI]

properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

Yamashita, Shinji

2006-10-26T23:59:59.000Z

36

Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance  

E-Print Network [OSTI]

period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

Clairambault, Jean

37

Predicting Student Retention and Academic Success at New Mexico Tech  

E-Print Network [OSTI]

Predicting Student Retention and Academic Success at New Mexico Tech by Julie Luna Submitted Research and Statistics Option New Mexico Institute of Mining and Technology Socorro, New Mexico August at the New Mexico Institute of Mining and Technology. Joe Franklin of the Information Services Department

Borchers, Brian

38

Retention of ferrite in AluminiumAlloyed TRIPassisted steels  

E-Print Network [OSTI]

Retention of ­ferrite in Aluminium­Alloyed TRIP­assisted steels Young Joo Choi1, Dong­Woo Suh1 of excess ­ferrite in the microstructure observed at ambient temperature. These provided valuable information for comparison against kinetic simulations which prove that the excess ferrite cannot

Cambridge, University of

39

Faculty Retention and Gender Adrienne Kertzer and Jenny Godley  

E-Print Network [OSTI]

1 Faculty Retention and Gender Adrienne Kertzer and Jenny Godley Advisory Committee on the Status, and home faculty; by year, rank, and total number of faculty members across the 1 E-mail Adrienne Kertzer, and total number of faculty members in the home faculty.3 In January 2013, Jenny Godley, Department

Calgary, University of

40

PLASTICIZER RETENTION IN PVC GEOMEMBRANES T. D. Stark1  

E-Print Network [OSTI]

1 PLASTICIZER RETENTION IN PVC GEOMEMBRANES T. D. Stark1 , H. Choi2 , and P. W. Diebel3 1, Ontario, Canada, N1R 5T6; PH (519)623-1630; email: PDiebel@cgtower.com ABSTRACT: Plasticizers are used to make PVC flexible so it can be used as a geomembrane for containment purposes. Plasticizers can migrate

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Evolutionary Computing for Detection of Retentive Structures in Coastal Waters  

E-Print Network [OSTI]

,robillia,poty,fonlupt}@lil.univ-littoral.fr, Abstract-- The demography of anchovy fishes in the Gulf of Biscay seems to be related to the presence of so- called "retentive" hydrodynamical structures, that keep fish eggs and larvae in a favorable environment be used to decide fishing quotas or bans for the sake of preserving the natural resource. We propose two

Fernandez, Thomas

42

Environmental measurement-while-drilling-gamma ray spectrometer (EMWD-GRS) system technology demonstration plan for use at the Savannah River Site F-Area Retention Basin  

SciTech Connect (OSTI)

The Environmental Measurement-While-Drilling-Gamma Ray Spectrometer (EMWD-GRS) system represents an innovative blend of new and existing technology that provides the capability of producing real-time environmental and drillbit data during drilling operations. This demonstration plan presents information on the EMWD-GRS technology, demonstration design, Cs-137 contamination at the Savannah River Site F-Area Retention Basin, responsibilities of demonstration participants, and the policies and procedures for the demonstration to be conducted at the Savannah River Site F-Area Retention Basin. The EMWD-GRS technology demonstration will consist of continuously monitoring for gamma-radiation contamination while drilling two horizontal boreholes below the backfilled retention basin. These boreholes will pass near previously sampled vertical borehole locations where concentrations of contaminant levels are known. Contaminant levels continuously recorded by the EMWD-GRS system during drilling will be compared to contaminant levels previously determined through quantitative laboratory analysis of soil samples.

Williams, C.V.; Lockwood, G.J.; Normann, R.A. [Sandia National Labs., Albuquerque, NM (United States)] [Sandia National Labs., Albuquerque, NM (United States); Gruebel, R.D. [Tech Reps, Inc., Albuquerque, NM (United States)] [Tech Reps, Inc., Albuquerque, NM (United States)

1996-08-01T23:59:59.000Z

43

Average Soil Water Retention Curves Measured by Neutron Radiography  

SciTech Connect (OSTI)

Water retention curves are essential for understanding the hydrologic behavior of partially-saturated porous media and modeling flow transport processes within the vadose zone. In this paper we report direct measurements of the main drying and wetting branches of the average water retention function obtained using 2-dimensional neutron radiography. Flint sand columns were saturated with water and then drained under quasi-equilibrium conditions using a hanging water column setup. Digital images (2048 x 2048 pixels) of the transmitted flux of neutrons were acquired at each imposed matric potential (~10-15 matric potential values per experiment) at the NCNR BT-2 neutron imaging beam line. Volumetric water contents were calculated on a pixel by pixel basis using Beer-Lambert s law after taking into account beam hardening and geometric corrections. To remove scattering effects at high water contents the volumetric water contents were normalized (to give relative saturations) by dividing the drying and wetting sequences of images by the images obtained at saturation and satiation, respectively. The resulting pixel values were then averaged and combined with information on the imposed basal matric potentials to give average water retention curves. The average relative saturations obtained by neutron radiography showed an approximate one-to-one relationship with the average values measured volumetrically using the hanging water column setup. There were no significant differences (at p < 0.05) between the parameters of the van Genuchten equation fitted to the average neutron radiography data and those estimated from replicated hanging water column data. Our results indicate that neutron imaging is a very effective tool for quantifying the average water retention curve.

Cheng, Chu-Lin [ORNL; Perfect, Edmund [University of Tennessee, Knoxville (UTK); Kang, Misun [ORNL; Voisin, Sophie [ORNL; Bilheux, Hassina Z [ORNL; Horita, Juske [Texas Tech University (TTU); Hussey, Dan [NIST Center for Neutron Research (NCRN), Gaithersburg, MD

2011-01-01T23:59:59.000Z

44

A Decentralized Public Key Infrastructure with Identity Retention Conner Fromknecht (conner@mit.edu), Dragos Velicanu (velicanu@mit.edu),  

E-Print Network [OSTI]

provided by cryptocurrencies such as Bitcoin and Namecoin to build a PKI that ensures identity retention

45

Chapter 3.5: Freshman Undergraduate Retention1 Improve retention and graduation rates for all first-year engineering undergraduate students,  

E-Print Network [OSTI]

Chapter 3.5: Freshman Undergraduate Retention1 Objective Improve retention and graduation rates graduation rate for transfer student. Strategies 1. Develop a program that continuously improves the delivery pass/fail efforts, either continue or adopt best practices form project for long-term implementation. 2

46

Noninvasive quantification of drug delivery from an implantable MEMS device  

E-Print Network [OSTI]

(cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

Johnson, Audrey M., 1976-

2005-01-01T23:59:59.000Z

47

Workforce Retention Work Group Status Overview - July 2012 | Department of  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartment of EnergyofProject isNovember 07,Energy Workforce Retention Work Group Status

48

Nuclear reactor melt-retention structure to mitigate direct containment heating  

DOE Patents [OSTI]

A light water nuclear reactor melt-retention structure to mitigate the extent of direct containment heating of the reactor containment building. The structure includes a retention chamber for retaining molten core material away from the upper regions of the reactor containment building when a severe accident causes the bottom of the pressure vessel of the reactor to fail and discharge such molten material under high pressure through the reactor cavity into the retention chamber. In combination with the melt-retention chamber there is provided a passageway that includes molten core droplet deflector vanes and has gas vent means in its upper surface, which means are operable to deflect molten core droplets into the retention chamber while allowing high pressure steam and gases to be vented into the upper regions of the containment building. A plurality of platforms are mounted within the passageway and the melt-retention structure to direct the flow of molten core material and help retain it within the melt-retention chamber. In addition, ribs are mounted at spaced positions on the floor of the melt-retention chamber, and grid means are positioned at the entrance side of the retention chamber. The grid means develop gas back pressure that helps separate the molten core droplets from discharged high pressure steam and gases, thereby forcing the steam and gases to vent into the upper regions of the reactor containment building.

Tutu, Narinder K. (Manorville, NY); Ginsberg, Theodore (East Setauket, NY); Klages, John R. (Mattituck, NY)

1991-01-01T23:59:59.000Z

49

E-Print Network 3.0 - age-dependent skeletal retention Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Riparian Forest Soil Jodi B. Lyons... of nutrients movingfrom the upland areas to aquatic eco- systems (Lowrance, 1991). Nutrient retention varies... is considered to be generally...

50

E-Print Network 3.0 - analysis retention behaviour Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delage (eds) 2008, Ecole des Ponts ParisTech, Champs-sur-Marne Summary: COMPACTED CLAYEY SOILS: MODELLING THE WATER RETENTION BEHAVIOUR Della Vecchia, G. (dellavecchia......

51

E-Print Network 3.0 - adopted hydraulic retention Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

curve for compacted clayey soils Different variables may adopted... COMPACTED CLAYEY SOILS: MODELLING THE WATER RETENTION BEHAVIOUR Della Vecchia, G. (dellavecchia......

52

E-Print Network 3.0 - additional retentive features Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

R. - Department of Medicinal Chemistry, University of Kansas Collection: Chemistry 8 Records Management USER GUIDE | II Summary: retention periods. In addition to the common...

53

E-Print Network 3.0 - anticancer drug carriers Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

results for: anticancer drug carriers Page: << < 1 2 3 4 5 > >> 1 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

54

UNC Tomorrow Phase II Campus Response Faculty and Staff Recruitment and Retention  

E-Print Network [OSTI]

1 UNC Tomorrow Phase II Campus Response Faculty and Staff Recruitment and Retention Submitted to/Tenure Track Faculty Hires 2009-2017 #12; 4 The projected demand for faculty and EPA and SPA staff create a range of implications for recruitment and retention in academic and non- academic units. The most

55

PPPL-3311, Preprint: August 1998, UC-420, 423 Modeling of Tritium Retention in TFTR*  

E-Print Network [OSTI]

- 1 - PPPL-3311, Preprint: August 1998, UC-420, 423 Modeling of Tritium Retention in TFTR* C Fusion Test Reactor tritium retention experience is reviewed and the data related to models of plasma surface interactions. Over 3.5 years of TFTR DT operations, approximately 51% of the tritium injected

56

Retention of Butt-End Aluminum Leg Bands by Wild Turkeys  

E-Print Network [OSTI]

Note Retention of Butt-End Aluminum Leg Bands by Wild Turkeys MATTHEW J. BUTLER,1,2 Department wild turkeys (Meleagris gallopavo intermedia) captured in Texas and Kansas, USA, 2000­2009. We examined 187 recaptured or harvested radiotagged wild turkeys to determine band retention and modeled band

Butler, Matthew J.

57

A LANDSCAPE SCALE EVALUATION OF PHOSPHORUS RETENTION IN WETLANDS OF THE  

E-Print Network [OSTI]

217 A LANDSCAPE SCALE EVALUATION OF PHOSPHORUS RETENTION IN WETLANDS OF THE LAPLATTE RIVER BASIN approach to examine phosphorus retention in wetlands of the LaPlatte River basin (13,723 ha), Vermont information system. Most wetland variables had significant (p

Wang, Deane

58

Understory plant communities of boreal mixedwood forests in western Canada: Natural patterns and response to variable-retention harvesting  

E-Print Network [OSTI]

and response to variable-retention harvesting S. Ellen Macdonald *, Treena E. Fenniak Department of Renewable, mixedwood, conifer) in Alberta, Canada, before and for 2 years following variable-retention harvesting conditions. Variable-retention harvesting had little effect on understory cover, richness, or diversity

Macdonald, Ellen

59

after which time 5-pL aliquots were taken to measure the PLA2activity (final concentrationof drug under assay conditions: 0.25 pM). Controls  

E-Print Network [OSTI]

5100 after which time 5-pL aliquots were taken to measure the PLA2activity (final concentrationof to measure the PLA2activity. Acknowledgment. This research was sponsored in part by Sea Grant Program

Collum, David B.

60

Quantification of absorption, retention and elimination of two different oral doses of vitamin A in Zambian boys using accelerator mass spectrometry  

SciTech Connect (OSTI)

A recent survey indicated that high-dose vitamin A supplements (HD-VAS) had no apparent effect on vitamin A (VA) status of Zambian children <5 y of age. To explore possible reasons for the lack of response to HD-VAS among Zambian children, we quantified the absorption, retention, and urinary elimination of either a single HDVAS (60 mg) or a smaller dose of stable isotope (SI)-labeled VA (5 mg), which was used to estimate VA pool size, in 3-4 y old Zambian boys (n = 4 for each VA dose). A 25 nCi tracer dose of [{sup 14}C{sub 2}]-labeled VA was co-administered with the HD-VAS or SI-labeled VA, and 24-hr stool and urine samples were collected for 3 and 7 consecutive days, respectively, and 24-hr urine samples at 4 later time points. Accelerator Mass Spectrometry (AMS) was used to measure the cumulative excretion of {sup 14}C in stool and urine 3d after dosing to estimate, respectively, absorption and retention of the VAS and SI-labeled VA. The urinary elimination rate (UER) was estimated by plotting {sup 14}C in urine vs. time, and fitting an exponential equation to the data. Estimates of mean absorption, retention and the UER were 83.8 {+-} 7.1%, 76.3 {+-} 6.7%, and 1.9 {+-} 0.6%/d, respectively, for the HD-VAS and 76.5 {+-} 9.5%, 71.1 {+-} 9.4%, and 1.8 {+-} 1.2%/d, respectively for the smaller dose of SI-labeled VA. Estimates of absorption, retention and the UER did not differ by size of the VA dose administered (P=0.26, 0.40, 0.88, respectively). Estimated absorption and retention were negatively associated with reported fever (P=0.011) and malaria (P =0.010). HD-VAS and SI-labeled VA were adequately absorbed, retained and utilized in apparently healthy Zambian preschool-age boys, although absorption and retention may be affected by recent infections.

Aklamati, E K; Mulenga, M; Dueker, S R; Buchholz, B A; Peerson, J M; Kafwembe, E; Brown, K H; Haskell, M J

2009-10-12T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Retention of Hydrogen Isotopes in Neutron Irradiated Tungsten  

SciTech Connect (OSTI)

To investigate the effects of neutron irradiation on hydrogen isotope retention in tungsten, disk-type specimens of pure tungsten were irradiated in the High Flux Isotope Reactor in Oak Ridge National Laboratory followed by exposure to high flux deuterium (D) plasma in Idaho National Laboratory. The results obtained for low dose n-irradiated specimens (0.025 dpa for tungsten) are reviewed in this paper. Irradiation at coolant temperature of the reactor (around 50 degrees C) resulted in the formation of strong trapping sites for D atoms. The concentrations of D in n-irradiated specimens were ranging from 0.1 to 0.4 mol% after exposure to D plasma at 200 and 500 degrees C and significantly higher than those in non-irradiated specimens because of D-trapping by radiation defects. Deep penetration of D up to a depth of 50-100 m was observed at 500 degrees C. Release of D in subsequent thermal desorption measurements continued up to 900 degrees C. These results were compared with the behaviour of D in ion-irradiated tungsten, and distinctive features of n-irradiation were discussed.

Yuji Hatano; Masashi Shimada; Yasuhisa Oya; Guoping Cao; Makoto Kobayashi; Masanori Hara; Brad J. Merrill; Kenji Okuno; Mikhail A. Sokolov; Yutai Katoh

2013-03-01T23:59:59.000Z

62

Increased intrapulmonary retention of radiolabeled neutrophils in early oxygen toxicity  

SciTech Connect (OSTI)

Sequential lung injuries, such as oxygen toxicity followed by septicemia, are common during the adult respiratory distress syndrome (ARDS). As these forms of vascular injury may be mediated in part by polymorphonuclear leukocytes (PMN), aberrant interactions between PMN and previously injured pulmonary endothelium are of both theoretical interest and clinical importance. The present study was undertaken to test the hypothesis that early oxygen toxicity at a dose that injuries pulmonary endothelium relatively selectively alters intrapulmonary neutrophil kinetics. Unanesthetized rats breathing 1.0 atmospheres oxygen for 36 h showed ultrastructural endothelial damage but no edema, injury, or neutrophilic inflammation by histologic criteria. However, in these oxygen-toxic animals, whereas initial accumulation of radiolabeled PMN in lungs was normal, washout of PMN was abnormal at 120 min after infusion, at which point the pulmonary retention of radiolabeled PMN in the lungs of oxygen-treated animals was significantly higher than in control animals (139% of control, p less than 0.0096). Features of our methodology, including avoidance of osmotic stress and use of paired control animals, appear to have greatly enhanced the sensitivity of radiolabeled neutrophils for detecting a subtle abnormality of neutrophil-endothelial interactions. Our studies in the oxygen toxicity model provide the first demonstration in vivo of abnormal intrapulmonary neutrophil kinetics in early oxygen toxicity prior to the onset of histologic evidence of lung injury or inflammation.

Rinaldo, J.E.; English, D.; Levine, J.; Stiller, R.; Henson, J.

1988-02-01T23:59:59.000Z

63

Formation and retention of methane in coal. Final report  

SciTech Connect (OSTI)

The formation and retention of methane in coalbeds was studied for ten Utah coal samples, one Colorado coal sample and eight coal samples from the Argonne Premium Coal Sample Bank.Methane gas content of the Utah and Colorado coals varied from zero to 9 cm{sup 3}/g. The Utah coals were all high volatile bituminous coals. The Colorado coal was a gassy medium volatile bituminous coal. The Argonne coals cover a range or rank from lignite to low volatile bituminous coal and were used to determine the effect of rank in laboratory studies. The methane content of six selected Utah coal seams and the Colorado coal seam was measured in situ using a special sample collection device and a bubble desorbometer. Coal samples were collected at each measurement site for laboratory analysis. The cleat and joint system was evaluated for the coal and surrounding rocks and geological conditions were noted. Permeability measurements were performed on selected samples and all samples were analyzed for proximate and ultimate analysis, petrographic analysis, {sup 13}C NMR dipolar-dephasing spectroscopy, and density analysis. The observed methane adsorption behavior was correlated with the chemical structure and physical properties of the coals.

Hucka, V.J.; Bodily, D.M.; Huang, H.

1992-05-15T23:59:59.000Z

64

E-Print Network 3.0 - anticancer drug delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Chemistry, University of Utah Collection: Chemistry 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

65

E-Print Network 3.0 - anticancer drug targets Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Toronto Collection: Biology and Medicine 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

66

SOIL MOISTURE RETENTION CHARACTERISTICS AND HYDRAULIC CONDUCTIVITY FOR DIFFERENT AREAS IN INDIA IN SELECTED STATES  

E-Print Network [OSTI]

SOIL MOISTURE RETENTION CHARACTERISTICS AND HYDRAULIC CONDUCTIVITY FOR DIFFERENT AREAS IN INDIA systems require knowledge of the relationships between soil moisture content (), soil water pressure (h) and unsaturated hydraulic conductivity (K). This study involved field and laboratory determination of soil

Kumar, C.P.

67

CHEMICAL TRACER RETENTION IN POROUS MEDIA Submitted to the Department of Petroleum Engineering  

E-Print Network [OSTI]

* CHEMICAL TRACER RETENTION IN POROUS MEDIA A Report Submitted to the Department of Petroleum Engineering of Stanford University in Fulfillment of the Requirement for the Degree of Master of Science

Stanford University

68

An Analysis of Texas Superintendents' Bilingual/ESL Teacher Recruitment and Retention Practices  

E-Print Network [OSTI]

year prior to the AAEE report, the Urban Teacher Collaborative Bilingual/ESL Teacher Recruitment/Retention 4 had already determined that bilingual educators were in very high demand, as were ESL teachers (The Urban Teacher Collaborative, 2000... organizations/conferences. Bilingual/ESL Teacher Recruitment/Retention 13 Several other questions related to recruitment were included on the survey. Response to a question related to in-district/in-state recruitment indicated that 53.4% (N=285...

Lara-Alecio, Rafael; Galloway, Martha; Irby, Beverly J.; Brown, Genevieve

2010-10-22T23:59:59.000Z

69

Retention of passive integrated transponder tags in largemouth bass brood fish  

SciTech Connect (OSTI)

Passive integrated transponder (PIT) tags were injected into 22 largemouth bass (Micropterus salmoides) brood fish to determine the retention rate of the tags, the effect on spawning success, and the utility of the tags as a means of individual fish identification. Fish were evaluated 12, 17, and 24 months after implantation. All tags were retained and all tagged fish were recognized. Tag injection and retention had no discernible effect on spawning success.

Harvey, W.D.; Campbell, D.L. (Texas Parks and Wildlife Dept., Austin (USA))

1989-07-01T23:59:59.000Z

70

Effect of graded hypoxia on retention of technetium-99m-nitroheterocycle in perfused rat heart  

SciTech Connect (OSTI)

The purpose of this investigation was to determine the effects of graded hypoxia on the retention of a {sup 99m}Tc-labeled nitroimidazole. Rat hearts were perfused retrogradely with Krebs-Henseleit buffer at 37{degrees}C and paced at 5 Hz. After a 20-min stabilization period, coronary flow was maintained at 8 ml/min/g wet wt and the hearts were perfused with media equilibrated with gas mixtures containing 5% CO{sub 2} and various levels of O{sub 2}, from 544 to 29 Torr. Technetium-99m-O(PnAO-1-(2-nitroimidazole)), BMS-181321, was infused for 20 min into a side port of the aortic cannula. Perfusion continued for an additional 40 min to allow for compound clearance. Each decrease of perfusate PO{sub 2} brought about an increase in the retention of BMS-181321, resulting in a good correlation between its retention and perfusate PO{sub 2} (r=0.97). Myocardial oxygen consumption was independent of oxygen delivery when the perfusate oxygen pressure was greater than 350 Torr. Below this value, oxygen consumption declined markedly as influent PO{sub 2}. A good correlation was obtained between retention of the nitroheterocycle and the cytosolic lactate/pyruvate ratio (r=0.98). When glucose was omitted from the perfusate (PO{sub 2}=27 Torr), retention of the nitroheterocycle was increased by about 25% as compared to hearts perfused in the presence of this substrate. These results indicate that myocardial retention of BMS-181321 is coupled to the level of tissue oxygenation and that hypoxic retention may be affected by substrate input. 24 refs., 3 figs., 1 tab.

Rumsey, W.L.; Patel, B.; Linder, K.E. [Bristol-Myers Squibb Pharmaceutical Research Inst., Princeton, NJ (United States)

1995-04-01T23:59:59.000Z

71

Multiresponse multilayer vadose zone model calibration using Markov chain Monte Carlo simulation and field water retention data  

E-Print Network [OSTI]

and field water retention data Thomas Wöhling1,2 and Jasper A. Vrugt3,4,5 Received 4 March 2010; revised 14

Vrugt, Jasper A.

72

MODELING SHALLOW GROUNDWATER TABLE CONTRIBUTION TO SOIL WATER RETENTION IN THE UNSATURATED ZONE OF A CALCAREOUS SOIL OF SOUTH  

E-Print Network [OSTI]

1 MODELING SHALLOW GROUNDWATER TABLE CONTRIBUTION TO SOIL WATER RETENTION IN THE UNSATURATED ZONE...................................................................................................................................13 CHAPTER 1 GENERAL INTRODUCTION.............................................................................................................................15 Shallow Groundwater Capillarity

Migliaccio, Kati White

73

Retention system and method for the blades of a rotary machine  

DOE Patents [OSTI]

A retention system and method for the blades of a rotary machine for preventing forward or aft axial movement of the rotor blades includes a circumferential hub slot formed about a circumference of the machine hub. The rotor blades have machined therein a blade retention slot which is aligned with the circumferential hub slot when the blades are received in correspondingly shaped openings in the hub. At least one ring segment is secured in the blade retention slots and the circumferential hub slot to retain the blades from axial movement. A key assembly is used to secure the ring segments in the aligned slots via a hook portion receiving the ring segments and a threaded portion that is driven radially outwardly by a nut. A cap may be provided to provide a redundant back-up load path for the centrifugal loads on the key. Alternatively, the key assembly may be formed in the blade dovetail.

Pedersen, Poul D. (Cincinnati, OH); Glynn, Christopher C. (Hamilton, OH); Walker, Roger C. (Piedmont, SC)

2002-01-01T23:59:59.000Z

74

antirheumatic drugs dmards: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

75

antineoplastic drugs: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

76

antineoplastic drugs chimio-radiotherapie: Topics by E-print...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

77

266 VOLUME 13 | NUMBER 3 | MARCH 2007 NATURE MEDICINE After decades of drought, new drug possibilities floodTB pipeline  

E-Print Network [OSTI]

possibilities floodTB pipeline For the first time in decades, there are nearly 30 drugs for tuberculosis (TB--but less than just five years ago, the pipeline was running empty. The newest drug used to treat the infection and don't interact with AIDS medications. "The drug pipeline is larger than it has ever been

Cai, Long

78

Competing retention pathways of uranium upon reaction with Fe(II)  

SciTech Connect (OSTI)

Biogeochemical retention processes, including adsorption, reductive precipitation, and incorporation into host minerals, are important in contaminant transport, remediation, and geologic deposition of uranium. Recent work has shown that U can become incorporated into iron (hydr)oxide minerals, with a key pathway arising from Fe(II)-induced transformation of ferrihydrite, (Fe(OH)3nH2O) to goethite (?-FeO(OH)); this is a possible U retention mechanism in soils and sediments. Several key questions, however, remain unanswered regarding U incorporation into iron (hydr)oxides and this pathways contribution to U retention, including: (i) the competitiveness of U incorporation versus reduction to U(IV) and subsequent precipitation of UO2; (ii) the oxidation state of incorporated U; (iii) the effects of uranyl aqueous speciation on U incorporation; and, (iv) the mechanism of U incorporation. Here we use a series of batch reactions conducted at pH ~7, [U(VI)] from 1 to 170 ?M, [Fe(II)] from 0 to 3 mM, and [Ca] at 0 or 4 mM) coupled with spectroscopic examination of reaction products of Fe(II)-induced ferrihydrite transformation to address these outstanding questions. Uranium retention pathways were identified and quantified using extended x-ray absorption fine structure (EXAFS) spectroscopy, x-ray powder diffraction, x-ray photoelectron spectroscopy, and transmission electron microscopy. Analysis of EXAFS spectra showed that 14 to 89% of total U was incorporated into goethite, upon reaction with Fe(II) and ferrihydrite. Uranium incorporation was a particularly dominant retention pathway at U concentrations ? 50 ?M when either uranyl-carbonato or calcium-uranyl-carbonato complexes were dominant, accounting for 64 to 89% of total U. With increasing U(VI) and Fe(II) concentrations, U(VI) reduction to U(IV) became more prevalent, but U incorporation remained a functioning retention pathway. These findings highlight the potential importance of U(V) incorporation within iron oxides as a retention process of U across a wide range of biogeochemical environments and the sensitivity of uranium retention processes to operative (bio)geochemical conditions.

Massey, Michael S.; Lezama Pacheco, Juan S.; Jones, Morris; Ilton, Eugene S.; Cerrato, Jose M.; Bargar, John R.; Fendorf, Scott

2014-10-01T23:59:59.000Z

79

Uptake and retention kinetics of para-fluorine-18-fluorobenzylguanidine in isolated rat heart  

SciTech Connect (OSTI)

Para-[{sup 18}F]fluorobenzylguanidine ([{sup 18}F]PFBG) is a newly developed tracer for imaging myocardial sympathetic neuronal innervation. This study investigated the uptake and retention mechanisms of [{sup 18}F]PFBG in perfused, isolated rat heart. 31 refs., 3 figs., 2 tabs.

Berry, C.R.; Garg, P.K.; Zalutsky, M.R. [North Carolina State Univ., Raleigh, NC (United States)]|[Duke Univ. Medical Center, Durham, NC (United States)] [and others

1996-12-01T23:59:59.000Z

80

SOIL MOISTURE RETENTION CHARACTERISTICS AT RD 838 OF I. G. N. P. STAGE -II  

E-Print Network [OSTI]

soil physical properties are those which govern the transport and storage of energy, momentum and mass1 SOIL MOISTURE RETENTION CHARACTERISTICS AT RD 838 OF I. G. N. P. STAGE - II C. P. Kumar* Sanjay knowledge of the relationships between soil moisture content (), soil water pressure (h) and unsaturated

Kumar, C.P.

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

A mathematical model for variation in water-retention curves among sandy soils  

E-Print Network [OSTI]

activity in soil varies with water content, soil texture and structure, temperature, energy and nutrientA mathematical model for variation in water-retention curves among sandy soils H.W. HUNT1 *, A@nrel.colostate.edu Abstract: Equations were developed to predict soil matric potential as a function of soil water content

Wall, Diana

82

Finance Program Retention for FALL 2014 Instructions for Transcript Review Form  

E-Print Network [OSTI]

Finance Program ­ Retention for FALL 2014 Instructions for Transcript Review Form College of Business at Northern Illinois University The Department of Finance Transcript Review Form should in the finance core). All NIU students are eligible to declare a major in Finance; however, students must meet

Kostic, Milivoje M.

83

Ca RETENTION IN YOUNG PULLETS AND LAYING HENS FED A Ca47 LABELLED DIET  

E-Print Network [OSTI]

Ca RETENTION IN YOUNG PULLETS AND LAYING HENS FED A Ca47 LABELLED DIET OF DIFFERENT Ca LEVELS K levels of dietary calcium. A basal diet poor in calcium but otherwise optimal was supplemented with CaC03 and Na2HP04 as seen below : #12;CaCO, supplement of the diet was replaced by Ca&dquo; labelled Calcium

Paris-Sud XI, Université de

84

Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism  

E-Print Network [OSTI]

Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism, March 16, 2000 (received for review February 17, 2000) Tyrosinase is a melanocyte-specific enzyme albino substitution TYR(T373K), and the temperature-sensitive tyrosinase TYR(R402Q) Tyr(H402A) found

Hebert, Daniel N.

85

Mesh Width Influences Prey Retention in Spider Orb Webs Todd A. Blackledge & Jacquelyn M. Zevenbergen  

E-Print Network [OSTI]

Mesh Width Influences Prey Retention in Spider Orb Webs Todd A. Blackledge & Jacquelyn M. Zevenbergen Department of Biology, The University of Akron, Akron, OH, USA Introduction Orb webs depend upon threads, the sticky spirals of orb webs perform two important functions during prey cap- ture. First

Blackledge, Todd

86

Recent Advances on Hydrogenic Retention in ITER's Plasma-Facing Materials: BE, C, W.  

SciTech Connect (OSTI)

Management of tritium inventory remains one of the grand challenges in the development of fusion energy and the choice of plasma-facing materials is a key factor for in-vessel tritium retention. The Atomic and Molecular Data Unit of the International Atomic Energy Agency organized a Coordinated Research Project (CRP) on the overall topic of tritium inventory in fusion reactors during the period 2001-2006. This dealt with hydrogenic retention in ITER's plasma-facing materials, Be, C, W, and in compounds (mixed materials) of these elements as well as tritium removal techniques. The results of the CRP are summarized in this article together with recommendations for ITER. Basic parameters of diffusivity, solubility and trapping in Be, C and W are reviewed. For Be, the development of open porosity can account for transient hydrogenic pumping but long term retention will be dominated by codeposition. Codeposition is also the dominant retention mechanism for carbon and remains a serious concern for both Be and C containing layers. Hydrogenic trapping in unirradiated tungsten is low but will increase with ion and neutron damage. Mixed materials will be formed in a tokamak and these can also retain significant amounts of hydrogen isotopes. Oxidative and photon-based techniques for detritiation of plasma-facing components are described.

Skinner, C H; Alimov, Kh; Bekris, N; Causey, R A; Clark, R.E.H.; Coad, J P; Davis, J W; Doerner, R P; Mayer, M; Pisarev, A; Roth, J; Tanabe, T

2008-03-29T23:59:59.000Z

87

Digestibility and energy retention by young rabbits fed different levels of intake  

E-Print Network [OSTI]

Note Digestibility and energy retention by young rabbits fed different levels of intake Fernando in digestibility cages, were fed a standard diet at four levels of intake: ad libitum (AL), 60, 40 and 10 % of the AL intake. Digestibility of dietary dry matter, organic matter, crude protein, ether extract and ash

Paris-Sud XI, Universit de

88

Strong-Sludge Gas Retention and Release Mechanisms in Clay Simulants  

SciTech Connect (OSTI)

The Hanford Site has 28 double-shell tanks (DSTs) and 149 single-shell tanks (SSTs) containing radioactive wastes that are complex mixes of radioactive and chemical products. The mission of the Department of Energy's River Protection Project is to retrieve and treat the Hanford tank waste for disposal and close the tank farms. A key aspect of the mission is to retrieve and transfer waste from the SSTs, which are at greater risk for leaking, into DSTs for interim storage until the waste is transferred to and treated in the Waste Treatment and Immobilization Plant. There is, however, limited space in the existing DSTs to accept waste transfers from the SSTs, and approaches to overcoming the limited DST space will benefit the overall mission. The purpose of this study is to summarize and analyze the key previous experiment that forms the basis for the relaxed controls and to summarize progress and results on new experiments focused on understanding the conditions that result in low gas retention. The previous large-scale test used about 50 m3 of sediment, which would be unwieldy for doing multiple parametric experiments. Accordingly, experiments began with smaller-scale tests to determine whether the desired mechanisms can be studied without the difficulty of conducting very large experiments. The most significant results from the current experiments are that progressively lower gas retention occurs in tests with progressively deeper sediment layers and that the method of gas generation also affects the maximum retention. Based on the results of this study, it is plausible that relatively low gas retention could occur in sufficiently deep tank waste in DSTs. The current studies and previous work, however, have not explored how gas retention and release will behave when two or more layers with different properties are present.

Gauglitz, Phillip A.; Buchmiller, William C.; Probert, Samuel G.; Owen, Antionette T.; Brockman, Fred J.

2012-02-24T23:59:59.000Z

89

April 2013 Most Viewed Documents for Biology And Medicine | OSTI...  

Office of Scientific and Technical Information (OSTI)

1981 Moody, J.B. (comp.) (1982) 306 > Drug Retention Times Center for Human Reliability Studies (2007) 99 > SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS....

90

Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery  

SciTech Connect (OSTI)

Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

Saha, Dipendu [ORNL] [ORNL; Warren, Kaitlyn E [ORNL] [ORNL; Naskar, Amit K [ORNL] [ORNL

2014-01-01T23:59:59.000Z

91

Rigor Through the Lens of Drug Discovery and Development  

E-Print Network [OSTI]

flavors of incentives: economic, social, and moral. Academic and Industrial cultures/ incentivesRigor Through the Lens of Drug Discovery and Development The game Culture and incentives Our and development? Resources: Money, time, and access to multiple non-academic skill sets Incentives/ Culture

92

Optimal periodic control of a drug delivery system Subbarao Varigonda 1  

E-Print Network [OSTI]

drug infusion strategies for maximizing a time averaged measure of drug effect are investigated infusion provides a locally improved average effect compared to steady infusion are characterized using 1­2 hr), as steady infusion leads to nearly complete sup- pression of gonadal function [24

Georgiou, Tryphon T.

93

A new metallographic procedure for edge retention of enclosed surfaces  

SciTech Connect (OSTI)

Utilization of a low melting point, metallic alloy that on solidification has provided a reproducible means of preserving edges and accurately measuring deposits on surfaces mounted for metarographic study. In normal laboratory practice the electrically conducting mounting material generates no hazardous waste, needs no special equipment to prepare and is available commercially at a relatively reasonable price. Previous standard edge preservation techniques were found to be 90% inefficient from a time utilization view compared with the new procedure. This new mounting procedure has greatly improved the quality and efficiency of microstructural studies of all materials, especially those on the inside diameters of heat exchanger components. These studies have included reaction products, shallow creep cracks and deposits on tubing, for which the procedure has proved indispensable.

Katz, O.M.

1994-08-01T23:59:59.000Z

94

Retention of Anionic Species on Granite: Influence of Granite Composition - 12129  

SciTech Connect (OSTI)

Technetium (Tc-99, T{sub 1/2} = 2.1.10{sup 5} yrs) and selenium (Se-79, T{sub 1/2} = 6.5.10{sup 4} yrs) belong among fission products, being produced by fission of nuclear fuel. Both elements can significantly contribute to risk due to their complicated chemistry, long life times, high mobility and prevailing anionic character. Therefore, knowledge of migration behaviour under different conditions can significantly improve input into performance and safety assessment models. Granite is considered as a potential host rock for deep geological disposal of radioactive waste in many countries. Granitic rocks consist usually of quartz, feldspar, plagioclase (main components), mica, chlorite, kaolinite (minor components). The main feature of the rock is advection governed transport in fractures, complemented with diffusion process from fracture towards undisturbed rock matrix. The presented work is focused on interaction of anionic species (TcO{sub 4}{sup -}, SeO{sub 4}{sup 2-}, SeO{sub 3}{sup 2-}) with granitic rock. Furthermore, the importance of mineral composition on sorption of anionic species was also studied. The batch sorption experiments were conducted on the crushed granite from Bohemian Massive. Five fractions with defined grain size were used for static batch method. Mineral composition of each granitic fraction was evaluated using X-ray diffraction. The results showed differences in composition of granitic fractions, even though originating from one homogenized material. Sorption experiments showed influence of granite composition on adsorption of both TcO4{sup -} and SeO3{sup 2-} on granitic rock. Generally, Se(IV) showed higher retention than Tc(VII). Se(VI) was not almost sorbed at all. Fe containing minerals are pronounced as a selective Se and Tc sorbent, being reduced on their surface. As micas in granite are usually enriched in Fe, increased sorption of anionic species onto mica enriched fractions can be explained by this reason. On the other hand, fractions enriched in feldspar did not show increased sorption affinity to Tc and Se. (authors)

Videnska, Katerina [Institute of Chemical Technology, Prague (Czech Republic); Havlova, Vaclava [Nuclear Research Institute Rez, Rez, 25068 (Czech Republic)

2012-07-01T23:59:59.000Z

95

A Discussion of SY-101 Crust Gas Retention and Release Mechanisms  

SciTech Connect (OSTI)

The flammable gas hazard in Hanford waste tanks was made an issue by the behavior of double-shell Tank (DST) 241-SY-101 (SY-101). Shortly after SY-101 was filled in 1980, the waste level began rising periodically, due to the generation and retention of gases within the slurry, and then suddenly dropping as the gases were released. An intensive study of the tank's behavior revealed that these episodic releases posed a safety hazard because the released gas was flammable, and, in some cases, the volume of gas released was sufficient to exceed the lower flammability limit (LFL) in the tank headspace (Allemann et al. 1993). A mixer pump was installed in SY-101 in late 1993 to prevent gases from building up in the settled solids layer, and the large episodic gas releases have since ceased (Allemann et al. 1994; Stewart et al. 1994; Brewster et al. 1995). However, the surface level of SY-101 has been increasing since at least 1995, and in recent months the level growth has shown significant and unexpected acceleration. Based on a number of observations and measurements, including data from the void fraction instrument (VFI), we have concluded that the level growth is caused largely by increased gas retention in the floating crust. In September 1998, the crust contained between about 21 and 43% void based on VFI measurements (Stewart et al. 1998). Accordingly, it is important to understand the dominant mechanisms of gas retention, why the gas retention is increasing, and whether the accelerating level increase will continue, diminish or even reverse. It is expected that the retained gas in the crust is flammable, with hydrogen as a major constituent. This gas inventory would pose a flammable gas hazard if it were to release suddenly. In May 1997, the mechanisms of bubble retention and release from crust material were the subject of a workshop. The evaluation of the crust and potential hazards assumed a more typical void of roughly 15% gas. It could be similar to percolati on in single-shell tank (SST) waste forms. The much higher void being currently observed in SY-101 represents essentially a new crust configuration, and the mechanisms for sudden gas release need to be evaluated. The purpose of this study is to evaluate the situation of gas bubbles in crust based on the previous work on gas bubble retention, migration, and release in simulants and actual waste. We have also conducted some visual observations of bubble migration through simulated crusts to help understand the interaction of the various mechanisms.

SD Rassat; PA Gauglitz; SM Caley; LA Mahoney; DP Mendoza

1999-02-23T23:59:59.000Z

96

Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug  

E-Print Network [OSTI]

Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

Carlyle, Wenda C.

97

Effects of Globally Waste Disturbing Activities on Gas Generation, Retention, and Release in Hanford Waste Tanks  

SciTech Connect (OSTI)

Various operations are authorized in Hanford single- and double-shell tanks that disturb all or a large fraction of the waste. These globally waste-disturbing activities have the potential to release a large fraction of the retained flammable gas and to affect future gas generation, retention, and release behavior. This report presents analyses of the expected flammable gas release mechanisms and the potential release rates and volumes resulting from these activities. The background of the flammable gas safety issue at Hanford is summarized, as is the current understanding of gas generation, retention, and release phenomena. Considerations for gas monitoring and assessment of the potential for changes in tank classification and steady-state flammability are given.

Stewart, Charles W.; Fountain, Matthew S.; Huckaby, James L.; Mahoney, Lenna A.; Meyer, Perry A.; Wells, Beric E.

2005-08-02T23:59:59.000Z

98

Rayleigh-Taylor Instability within Sediment Layers Due to Gas Retention: Preliminary Theory and Experiments  

SciTech Connect (OSTI)

In Hanford underground waste storage tanks, a typical waste configuration is settled beds of waste particles beneath liquid layers. The settled beds are typically composed of layers, and these layers can have different physical and chemical properties. One postulated configuration within the settled bed is a less-dense layer beneath a more-dense layer. The different densities can be a result of different gas retention in the layers or different degrees of settling and compaction in the layers. This configuration can experience a Rayleigh-Taylor (RT) instability where the less dense lower layer rises into the upper layer. Previous studies of gas retention and release have not considered potential buoyant motion within a settle bed of solids. The purpose of this report is to provide a review of RT instabilities, discuss predictions of RT behavior for sediment layers, and summarize preliminary experimental observations of RT instabilities in simulant experiments.

Gauglitz, Phillip A.; Wells, Beric E.; Buchmiller, William C.; Rassat, Scot D.

2013-03-21T23:59:59.000Z

99

Retention sleeve for a thermal medium carrying tube in a gas turbine  

DOE Patents [OSTI]

Multiple tubes are connected to steam supply and spent cooling steam return manifolds for supplying cooling steam to buckets and returning spent cooling steam from the buckets to the manifolds, respectively. The tubes are prevented from axial movement in one direction by flanges engaging end faces of the spacer between the first and second-stage wheels. Retention sleeves are disposed about cantilevered ends of the tubes. One end of the retention sleeve engages an enlarged flange on the tube, while an opposite end is spaced axially from an end face of the adjoining wheel, forming a gap, enabling thermal expansion of the tubes and limiting axial displacement of the tube in the opposite direction.

Lathrop, Norman Douglas (Ballston Lake, NY); Czachor, Robert Paul (Cincinnati, OH)

2003-01-01T23:59:59.000Z

100

Solute retention in column liquid chromatography. X. Determination of solute infinite-dilution activity coefficients in methanol, water, and their mixtures, by combined gas-liquid and liquid-liquid chromatography  

SciTech Connect (OSTI)

The Raoult's-law activity coefficients of 3- to 7-carbon aliphatic aldehyde, ketone, ester, and alcohol solutes at infinite dilution in methanol, water, and mixtures of the two and in polydimethysiloxane, all at 293-308 K, have been determined for the first time by appropriate combination of GLC and LLC retention data. The latter data are reported in terms of mole factions, while the former are given in concentration units of molality. However, interpretation of the data is difficult because of the multiplicity of the retention mechanisms. Nevertheless, the combined GLC/LLC technique, which had been applied previously only to pure solvents, is said to offer a number of advantages over static techniques for the determination of solute infinite-dilution activity coefficients with volatile solvents, especially with mixtures of solvents.

Djerki, R.A.; Laub, R.J.

1988-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Recruitment and retention initiatives for African American and Hispanic teachers in selected school districts in Texas  

E-Print Network [OSTI]

RECRUITMENT AND RETENTION INITIATIVES FOR AFRICAN AMERICAN AND HISPANIC TEACHERS IN SELECTED SCHOOL DISTRICTS IN TEXAS A Dissertation by ANITA JANE PERRY Submitted to the Office of Graduate Studies of Texas A&M University... IN SELECTED SCHOOL DISTRICTS IN TEXAS A Dissertation by ANITA JANE PERRY Submitted to Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved as to style and content by...

Perry, Anita Jane

2005-08-29T23:59:59.000Z

102

Heterosis and Heterosis Retention for Reproductive and Maternal Traits in Nellore-Angus Crossbred Cows  

E-Print Network [OSTI]

HETEROSIS AND HETEROSIS RETENTION FOR REPRODUCTIVE AND MATERNAL TRAITS IN NELLORE-ANGUS CROSSBRED COWS A Dissertation by MOHAMMAD DIYA TALAL HAMED OBEIDAT Submitted to the Office of Graduate Studies of Texas A&M University in partial... Subject: Animal Breeding Copyright 2013 Mohammad Diya Talal Hamed Obeidat ii ABSTRACT Calving rate, weaning rate, birth weight, weaning weight, and ADG from 1997 to 2011 were investigated in Angus, Nellore, F1 Nellore-Angus, first generation 3...

Obeidat, Mohammad Diya Talal Hamed

2013-07-08T23:59:59.000Z

103

A Study of Prevention and Retention Strategies for Successful Urban Secondary High School Hispanic Students  

E-Print Network [OSTI]

A STUDY OF PREVENTION AND RETENTION STRATEGIES FOR SUCCESSFUL URBAN SECONDARY HIGH SCHOOL HISPANIC STUDENTS A Dissertation by ROBERTO IBARRA LOPEZ Submitted to the Office of Graduate Studies of Texas A&M University... in partial fulfillment of the requirements for the degree of DOCTOR OF EDUCATION Approved by: Chair of Committee, Mario S. Torres Committee Members, Virginia Collier Larry Dooley Ben Welch Head of Department, Fredrick M. Nafukho May 2013...

Lopez, Roberto I

2013-01-14T23:59:59.000Z

104

Professional School Psychology Programs' Recruitment and Retention of Culturally and Linguistically Diverse Students  

E-Print Network [OSTI]

graduate students of color. American Psychologist, 61, 143-156. Sanders, J. B., Wilson, M., & Jones, J. (2010). Generating Markets: Recruitment for programs and program faculty, encouraging diversity. Trainers Forum, 29 (2),32-35. Solomon, David J... PROFESSIONAL PSYCHOLOGY PROGRAMS? RECRUITMENT AND RETENTION OF CULTURALLY AND LINGUISTICALLY DIVERSE STUDENTS Major: Mathematics April 2011 Submitted to the Office of Undergraduate Research Texas A&M University...

Smith, Leann

2011-08-08T23:59:59.000Z

105

Describing the readiness for retention of students of color at state and land-grant colleges of agriculture  

E-Print Network [OSTI]

are not done in this area considering the fiscal impacts on priorities such as retention. Although respondents indicated satisfaction with the college of agriculture to meet the academic needs of students, departmental administrators and faculty were still...

Harris, Danielle Alexander

2007-04-25T23:59:59.000Z

106

Investigation of the use of nanofluids to enhance the In-Vessel Retention capabilities of Advanced Light Water Reactors  

E-Print Network [OSTI]

Nanofluids at very low concentrations experimentally exhibit a substantial increase in Critical Heat Flux (CHF) compared to water. The use of a nanofluid in the In-Vessel Retention (IVR) severe accident management strategy, ...

Hannink, Ryan Christopher

2007-01-01T23:59:59.000Z

107

Investigation of downward facing critical heat flux with water-based nanofluids for In-Vessel Retention applications  

E-Print Network [OSTI]

In-Vessel Retention ("IVR") is a severe accident management strategy that is power limiting to the Westinghouse AP1000 due to critical heat flux ("CHF") at the outer surface of the reactor vessel. Increasing the CHF level ...

DeWitt, Gregory L

2011-01-01T23:59:59.000Z

108

A bright idea? : the promise and peril of a memory drug  

E-Print Network [OSTI]

In the MIT lab of neuropharmacologist Richard Wurtman, rodents that received a new Alzheimer's drug have shown a marked improvement in learning and memory. They are able to master elaborate mazes in half the time of their ...

Dowd, William (William Michael)

2007-01-01T23:59:59.000Z

109

Systems level characterizations of single and combination drug mechanisms of action in vitro and in vivo  

E-Print Network [OSTI]

Small molecule characterization is a critical limiting step in cancer drug development. At the present time, high throughput screens of natural products and combinatorial synthesis libraries generate more pharmaceutical ...

Pritchard, Justin (Justin Robert)

2012-01-01T23:59:59.000Z

110

The effect of stone retention walls on soil productivity and crop performance on selected hillside farms in southern Honduras  

E-Print Network [OSTI]

THE EFFECT OF STONE RETENTION WALLS ON SOIL PRODUCTIVITY AND CROP PERFORMANCE ON SELECTED HILLSIDE FARMS IN SOUTHERN HONDURAS A Thesis by MARC ELLERY THOMPSON Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1992 Major Subject Soil Science THE EFFECT OF STONE RETENTION WALLS ON SOIL PRODUCTIVITY AND CROP PERFORMANCE ON SELECTED HILLSIDE FARMS IN SOUTHERN HONDURAS A Thesis by MARC...

Thompson, Marc Ellery

1992-01-01T23:59:59.000Z

111

Exhibit 1C Patent Rights Retention by the Seller ITER UT-B Contracts Div Page 1 of 5  

E-Print Network [OSTI]

Exhibit 1C ­ Patent Rights ­ Retention by the Seller ­ ITER UT-B Contracts Div March 2007 Page 1 of 5 ex1c-ITER-mar07.doc Exhibit 1C ­ ITER Ref: DEAR 952.227-11 PATENT RIGHTS - RETENTION BY THE SELLER is or may be patentable or otherwise protectable under title 35 of the United States Code, or any novel

Pennycook, Steve

112

antiepileptic drug effects: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

113

Comparison of mean retention time (MRT) of markers in the reticulorumen (RR) estimated by modelling their faecal  

E-Print Network [OSTI]

-EDTA) were injected via the rumen cannula through the reticulo-omasal orifice prior to duodenal sampling (9 by modelling and algebraic methods were close. Markers (digesta phases) had an effect on accuracy of MRTRR

Paris-Sud XI, Université de

114

SUMMARY OF FY11 SULFATE RETENTION STUDIES FOR DEFENSE WASTE PROCESSING FACILITY GLASS  

SciTech Connect (OSTI)

This report describes the results of studies related to the incorporation of sulfate in high level waste (HLW) borosilicate glass produced at the Savannah River Site (SRS) Defense Waste Processing Facility (DWPF). A group of simulated HLW glasses produced for earlier sulfate retention studies was selected for full chemical composition measurements to determine whether there is any clear link between composition and sulfate retention over the compositional region evaluated. In addition, the viscosity of several glasses was measured to support future efforts in modeling sulfate solubility as a function of predicted viscosity. The intent of these studies was to develop a better understanding of sulfate retention in borosilicate HLW glass to allow for higher loadings of sulfate containing waste. Based on the results of these and other studies, the ability to improve sulfate solubility in DWPF borosilicate glasses lies in reducing the connectivity of the glass network structure. This can be achieved, as an example, by increasing the concentration of alkali species in the glass. However, this must be balanced with other effects of reduced network connectivity, such as reduced viscosity, potentially lower chemical durability, and in the case of higher sodium and aluminum concentrations, the propensity for nepheline crystallization. Future DWPF processing is likely to target higher waste loadings and higher sludge sodium concentrations, meaning that alkali concentrations in the glass will already be relatively high. It is therefore unlikely that there will be the ability to target significantly higher total alkali concentrations in the glass solely to support increased sulfate solubility without the increased alkali concentration causing failure of other Product Composition Control System (PCCS) constraints, such as low viscosity and durability. No individual components were found to provide a significant improvement in sulfate retention (i.e., an increase of the magnitude necessary to have a dramatic impact on blending, washing, or waste loading strategies for DWPF) for the glasses studied here. In general, the concentrations of those species that significantly improve sulfate solubility in a borosilicate glass must be added in relatively large concentrations (e.g., 13 to 38 wt % or more of the frit) in order to have a substantial impact. For DWPF, these concentrations would constitute too large of a portion of the frit to be practical. Therefore, it is unlikely that specific additives may be introduced into the DWPF glass via the frit to significantly improve sulfate solubility. The results presented here continue to show that sulfate solubility or retention is a function of individual glass compositions, rather than a property of a broad glass composition region. It would therefore be inappropriate to set a single sulfate concentration limit for a range of DWPF glass compositions. Sulfate concentration limits should continue to be identified and implemented for each sludge batch. The current PCCS limit is 0.4 wt % SO{sub 4}{sup 2-} in glass, although frit development efforts have led to an increased limit of 0.6 wt % for recent sludge batches. Slightly higher limits (perhaps 0.7-0.8 wt %) may be possible for future sludge batches. An opportunity for allowing a higher sulfate concentration limit at DWPF may lay lie in improving the laboratory experiments used to set this limit. That is, there are several differences between the crucible-scale testing currently used to define a limit for DWPF operation and the actual conditions within the DWPF melter. In particular, no allowance is currently made for sulfur partitioning (volatility versus retention) during melter processing as the sulfate limit is set for a specific sludge batch. A better understanding of the partitioning of sulfur in a bubbled melter operating with a cold cap as well as the impacts of sulfur on the off-gas system may allow a higher sulfate concentration limit to be established for the melter feed. This approach would have to be taken carefully to ensure that a

Fox, K.; Edwards, T.

2012-05-08T23:59:59.000Z

115

Soil Water Retention and Relative Permeability for Full Range of Saturation  

SciTech Connect (OSTI)

Common conceptual models for unsaturated flow often rely on the oversimplified representation of medium pores as a bundle of cylindrical capillaries and assume that the matric potential is attributed to capillary forces only. The adsorptive surface forces are ignored. It is often assumed that aqueous flow is negligible when a soil is near or at the residual water content. These models are successful at high and medium water contents but often give poor results at low water contents. These models do not apply to conditions at which water content is less than the residual water content. We extend the lower bound of existing water-retention functions and conductivity models from residual water content to the oven-dry condition (i.e., zero water content) by defining a state-dependent, residual-water content for a soil drier than a critical value. Furthermore, a hydraulic conductivity model for smooth uniform spheres was modified by introducing a correction factor to describe the film flow-induced hydraulic conductivity for natural porous media. The total unsaturated hydraulic conductivity is the sum of those due to capillary and film flow. The extended retention and conductivity models were verified with six datasets from the literature. Results show that, when the soil is at high and intermediate water content, there is no difference between the un-extended and the extended models; when the soil is at low water content, the un-extended models overestimate the water content but under-estimate the conductivity while the extended models match the retention and conductivity measurements well.

Zhang, Z. F.

2010-09-28T23:59:59.000Z

116

Joint production and economic retention quantity decisions in capacitated production systems serving multiple market segments  

E-Print Network [OSTI]

: : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : 44 VITA : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : 46 viii LIST OF FIGURES FIGURE Page 1 Sensitivity of the economic retention quantity with respect to the lost sales penalty when r1 = 100, p = 50, h = 12:5, E[X1...] = E[X2] = E[X3] = 100, C1 = C2 = C2 = 100 : : : : : : : : : : : : : : 36 2 Sensitivity of the optimal-produce up-to level with respect to the lost sales penalty when r1 = 100, p = 50, r2 = 40, h = 12:5, E[X1] = E[X2] = E[X3] = 100, C1 = C2 = C2 = 100...

Katariya, Abhilasha Prakash

2009-05-15T23:59:59.000Z

117

Time dependences of atmospheric Carbon dioxide fluxes  

E-Print Network [OSTI]

Understanding the lifetime of CO2 in the atmosphere is critical for predictions regarding future climate changes. A simple mass conservation analysis presented here generates tight estimations for the atmosphere's retention time constant. The analysis uses a leaky integrator model that combines the observed deficit (only less than 40% of CO2 produced from combustion of fossil fuels is actually retained in the atmosphere, while more than 60% is continuously shed) with the exponential growth of fossil fuel burning. It reveals a maximum characteristic time of less than 23 year for the transfer of atmospheric CO2 to a segregation sink. This time constant is further constrained by the rapid disappearance of 14C after the ban of atmospheric atomic bomb tests, which provides a lower limit of 18 years for this transfer. The study also generates evaluations of other CO2 fluxes, exchange time constants and volumes exchanged. Analysis of large harmonic oscillations of atmospheric CO2 concentration, often neglected in th...

DeSalvo, Riccardo

2014-01-01T23:59:59.000Z

118

RETENTION AND CHEMICAL SPECIATION OF URANIUM IN A WETLAND ON THE SAVANNAH RIVER SITE  

SciTech Connect (OSTI)

Uranium speciation and retention mechanism onto Savannah River Site (SRS) wetland sediments was studied using batch (ad)sorption experiments, sequential extraction desorption tests and U L{sub 3}-edge X-ray absorption near-edge structure (XANES) spectroscopy of contaminated wetland sediments. U was highly retained by the SRS wetland sediments. In contrast to other similar but much lower natural organic matter (NOM) sediments, significant sorption of U onto the SRS sediments was observed at pH <4 and pH >8. Sequential extraction tests indicated that the U(VI) species were primarily associated with the acid soluble fraction (weak acetic acid extractable) and NOM fraction (Na-pyrophosphate extractable). Uranium L3- edge XANES spectra of the U-retained sediments were nearly identical to that of uranyl acetate. The primary oxidation state of U in these sediments was as U(VI), and there was little evidence that the high sorptive capacity of the sediments could be ascribed to abiotic or biotic reduction to the less soluble U(IV) species. The molecular mechanism responsible for the high U retention in the SRS wetland sediments is likely related to the chemical bonding of U to organic carbon.

Li, D.; CHANG, H.: SEAMAN, J.; Jaffe, P.; Groos, P.; Jiang, D.; Chen, N.; Lin, J.; Arthur, Z.; Scheckel, K.; Kaplan, D.

2013-06-17T23:59:59.000Z

119

Radionuclide Retention Mechanisms in Secondary Waste-Form Testing: Phase II  

SciTech Connect (OSTI)

This report describes the results from laboratory tests performed at Pacific Northwest National Laboratory (PNNL) for Washington River Protection Solutions (WRPS) to evaluate candidate stabilization technologies that have the potential to successfully treat liquid secondary waste stream effluents produced by the Hanford Tank Waste Treatment and Immobilization Plant (WTP). WRPS is considering the design and construction of a Solidification Treatment Unit (STU) for the Effluent Treatment Facility (ETF) at Hanford. The ETF, a multi-waste, treatment-and-storage unit that has been permitted under the Resource Conservation and Recovery Act (RCRA), can accept dangerous, low-level, and mixed wastewaters for treatment. The STU needs to be operational by 2018 to receive secondary liquid waste generated during operation of the WTP. The STU will provide the additional capacity needed for ETF to process the increased volume of secondary waste expected to be produced by WTP. This report on radionuclide retention mechanisms describes the testing and characterization results that improve understanding of radionuclide retention mechanisms, especially for pertechnetate, {sup 99}TcO{sub 4}{sup -} in four different waste forms: Cast Stone, DuraLith alkali aluminosilicate geopolymer, encapsulated fluidized bed steam reforming (FBSR) product, and Ceramicrete phosphate bonded ceramic. These data and results will be used to fill existing data gaps on the candidate technologies to support a decision-making process that will identify a subset of the candidate waste forms that are most promising and should undergo further performance testing.

Um, Wooyong; Valenta, Michelle M.; Chung, Chul-Woo; Yang, Jungseok; Engelhard, Mark H.; Serne, R. Jeffrey; Parker, Kent E.; Wang, Guohui; Cantrell, Kirk J.; Westsik, Joseph H.

2011-09-26T23:59:59.000Z

120

Neuroimaging for drug addiction and related behaviors  

SciTech Connect (OSTI)

In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

2011-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Rethinking Americas Illegal Drug Policy  

E-Print Network [OSTI]

treatment); health care costs (drug-related illnesses, injuries); reduced performance in school; reduced performance at workplace; poor parenting, child abuse;

Donohue III, John J.

2011-01-01T23:59:59.000Z

122

FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS  

E-Print Network [OSTI]

Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs ...

Flynn, Colleen A.

2011-12-31T23:59:59.000Z

123

Mechanical loading impacts intramuscular drug transport : impact on local drug delivery  

E-Print Network [OSTI]

Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue ...

Wu, Peter I-Kung

2008-01-01T23:59:59.000Z

124

Entropic Time  

SciTech Connect (OSTI)

The formulation of quantum mechanics within the framework of entropic dynamics includes several new elements. In this paper we concentrate on one of them: the implications for the theory of time. Entropic time is introduced as a book-keeping device to keep track of the accumulation of changes. One new feature is that, unlike other concepts of time appearing in the so-called fundamental laws of physics, entropic time incorporates a natural distinction between past and future.

Caticha, Ariel [Department of Physics, University at Albany-SUNY, Albany, NY 12222 (United States)

2011-03-14T23:59:59.000Z

125

antiretroviral treatment start-time: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

parking, depending on time Sjlander, Kimmen 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

126

Plant and microbial controls on nitrogen retention and loss in a Humid Tropical Forest  

SciTech Connect (OSTI)

Humid tropical forests are generally characterized by the lack of nitrogen (N) limitation to net primary productivity, yet paradoxically have high potential for N loss. We conducted an intensive field experiment with {sup 15}NH{sub 4} and {sup 15}NO{sub 3} additions to highly weathered tropical forest soils to determine the relative importance of N retention and loss mechanisms. Over half of all the NH{sub 4}{sup +} produced from gross mineralization was rapidly converted to NO{sub 3}{sup -} during the process of gross nitrification. During the first 24 h plant roots took up 28 % of the N mineralized, dominantly as NH{sub 4}{sup +}, and were a greater sink for N than soil microbial biomass. Soil microbes were not a significant sink for added {sup 15}NH{sub 4}{sup +} or {sup 15}NO{sub 3}{sup -} during the first 24 hr, and only for {sup 15}NH{sub 4}{sup +} after 7 d. Patterns of microbial community composition, as determined by Terminal Restriction Fragment Length Polymorphism analysis, were weakly, but significantly correlated with nitrification and denitrification to N{sub 2}O. Rates of dissimilatory NO{sub 3}{sup -} reduction to NH{sub 4}{sup +} (DNRA) were high in this forest, accounting for up to 25 % of gross mineralization and 35 % of gross nitrification. DNRA was a major sink for NO{sub 3}{sup -} which may have contributed to the lower rates of N{sub 2}O and leaching losses. Despite considerable N conservation via DNRA and plant NH{sub 4}{sup +} uptake, the fate of approximately 45% of the NO{sub 3}{sup -} produced and 22% of the NH{sub 4}{sup +} produced were not measured in our fluxes, suggesting that other important pathways for N retention and loss (e.g., denitrification to N{sub 2}) are important in this system. The high proportion of mineralized N that was rapidly nitrified and the fates of that NO{sub 3}{sup -} highlight the key role of gross nitrification as a proximate control on N retention and loss in humid tropical forest soils. Furthermore, our results demonstrate the importance of the coupling between DNRA and plant uptake of NH{sub 4}{sup +} as a potential N conserving mechanism within tropical forests.

Templer, P.; Silver, W.; Pett-Ridge, J.; DeAngelis, K.M.; Firestone, M.K.

2009-09-15T23:59:59.000Z

127

Novel polyoxazolines polymer drug delivery platform  

E-Print Network [OSTI]

performed with 4 different polymers in multi- drug resistant (MCF7/ADR) human adenocarcinoma cells, non-resistant (MCF7) human adenocarcinoma cells and Madin-Darby canine kidney (MDCK) cells. All polymers were found lines. 2. To investigate the effect of the addition of drugs to the polymers on cell toxicity, micelles

128

Pricing in the Market for Anticancer Drugs  

E-Print Network [OSTI]

In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab brand name Yervoyat $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

Howard, David H.

129

Chemical Innovation in Drug Dr Matthew Fuchter  

E-Print Network [OSTI]

Chemical Innovation in Drug Discovery Dr Matthew Fuchter Lecturer in Synthetic and Medicinal&D Spending and Output #12;Chemical Innovation Impact Discovery Development Basic research: years 0-3 Pre 3, File DRUG Chemical start point Hit to lead Preclinical Assessment Synthetic Chemistry Chemistry

130

The World of Youthful Drug Use  

E-Print Network [OSTI]

they meet the fact that the use of drugs is illegal and exposes them to arrest and criminal prosecution. It was obvious that such kinds of information could be secured: only from the youths who were themselves in the drug using world. We could not rely on a...

Blumer, Herbert; Sutter, Alan; Smith, Roger; Ahmed, Samir

2000-04-01T23:59:59.000Z

131

Influence of pH on Phosphorus Retention in Oxidized Lake Sediments O. G. Olila* and K. R. Reddy  

E-Print Network [OSTI]

Influence of pH on Phosphorus Retention in Oxidized Lake Sediments O. G. Olila* and K. R. Reddy-soluble P concentration (WSP) and P sorption by suspended sediments in shallow eutrophic lakes. Labora- tory sediment suspensions from two subtropical lakes (Lake Apopka and Lake Okeechobee, Florida). The P sorption

Florida, University of

132

Enhancement of water retention in the membrane electrode assembly for direct methanol fuel cells operating with neat  

E-Print Network [OSTI]

to achieve the neat-methanol operation is to passively transport the water produced at the cathode throughEnhancement of water retention in the membrane electrode assembly for direct methanol fuel cells operating with neat methanol Q.X. Wu, T.S. Zhao*, R. Chen, W.W. Yang Department of Mechanical Engineering

Zhao, Tianshou

133

ISU Policy Library All of this information can be found Under the ISU Policy Library --File retention.  

E-Print Network [OSTI]

ISU Policy Library All of this information can be found Under the ISU Policy Library -- File retention. http://records.policy.iastate.edu/ Here are a few links we pulled out for you to get you started: · Personnel Files -- http://records.policy.iastate.edu/view.php?id=151 · Accounting Transactions

Chen, Tsing-Chang "Mike"

134

Colloids and Surfaces A: Physicochem. Eng. Aspects 289 (2006) 254255 Erratum to "Retention of mineral colloids in unsaturated  

E-Print Network [OSTI]

Colloids and Surfaces A: Physicochem. Eng. Aspects 289 (2006) 254­255 Erratum Erratum to "Retention. Physicochem. Eng. Aspects 256 (2005) 207­216) Gang Chen, Markus Flury Department of Crop and Soil Sciences.colsurfa.2006.06.029 #12;G. Chen, M. Flury / Colloids and Surfaces A: Physicochem. Eng. Aspects 289 (2006) 254

Flury, Markus

135

Colloids and Surfaces A: Physicochem. Eng. Aspects 256 (2005) 207216 Retention of mineral colloids in unsaturated porous  

E-Print Network [OSTI]

Colloids and Surfaces A: Physicochem. Eng. Aspects 256 (2005) 207­216 Retention of mineral colloids theory, where removal of col- loidal particles from the fluid phase is governed by physico- chemical transport is also subject to physical constraint, i.e., colloid physical entrap- ment in pore throats

Flury, Markus

136

RETENTION OF IRB RECORDS AND OTHER DOCUMENTS All IRB files and documents that relate to the protection of human research  

E-Print Network [OSTI]

site. The IRB File Manager and eIRB support staff are available to scan paper documents as needed into Paperhost. The File Manager and all the Board Specialists have access to documents kept on the Paperhost web1 RETENTION OF IRB RECORDS AND OTHER DOCUMENTS 04/18/2011 All IRB files and documents that relate

137

anti-parkinsonian drug selegiline: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

138

E-Print Network 3.0 - adverse antiepileptic drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... Dosage Same or different? A drug in a different...

139

Controlling drug delivery across the placenta: A commentary  

E-Print Network [OSTI]

A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ...

Audus, Kenneth L.

1999-01-01T23:59:59.000Z

140

WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria  

E-Print Network [OSTI]

14 WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria Vincent Breton, Doman Kim ................................................................................ 354 14.2 Grid-Enabled Drug Discovery .................................................. 354 14.2.1 In Silico Drug Discovery: Requirements and Grid Added Value

Paris-Sud XI, Universit de

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network [OSTI]

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

142

Structural genomics of infectious disease drug targets: the SSGCID...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

143

Drugs and oil flow through the Eagle Ford Shale.  

E-Print Network [OSTI]

??This report is a work of original reporting which investigates the proliferation of drug use and drug trafficking in the Eagle Ford Shale, a region (more)

Marks, Michael Perry

2014-01-01T23:59:59.000Z

144

E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

145

antiepileptic drug development: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of drug design and development Bommarius Reading Jan 15 Tutorial Sherrill, David 28 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

146

Intradermal needle-free powdered drug injection  

E-Print Network [OSTI]

This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

Liu, John (John Hsiao-Yung)

2012-01-01T23:59:59.000Z

147

Alcohol and Other Drugs Education and Prevention  

E-Print Network [OSTI]

Free Workplace Policy. 2.0 POLICY STATEMENT In compliance with the federal government's Drug Free, because of Mines' status as a federal contractor and grant recipient and because marijuana use is still

148

Transdermal drug delivery by localized intervention  

E-Print Network [OSTI]

Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

Weaver, James C.

149

Computational model of local intravascular drug delivery  

E-Print Network [OSTI]

Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

Balakrishnan, Brinda

2007-01-01T23:59:59.000Z

150

In-vessel coolability and retention of a core melt. Volume 2  

SciTech Connect (OSTI)

The efficacy of external flooding of a reactor vessel as a severe accident management strategy is assessed for an AP600-like reactor design. The overall approach is based on the Risk Oriented Accident Analysis Methodology (ROAAM), and the assessment includes consideration of bounding scenarios and sensitivity studies, as well as arbitrary parametric evaluations that allow the delineation of the failure boundaries. Quantification of the input parameters is carried out for an AP600-like design, and the results of the assessment demonstrate that lower head failure is physically unreasonable. Use of this conclusion for any specific application is subject to verifying the required reliability of the depressurization and cavity-flooding systems, and to showing the appropriateness (in relation to the database presented here, or by further testing as necessary) of the thermal insulation design and of the external surface properties of the lower head, including any applicable coatings. The AP600 is particularly favorable to in-vessel retention. Some ideas to enhance the assessment basis as well as performance in this respect, for applications to larger and/or higher power density reactors are also provided.

Theofanous, T.G.; Liu, C.; Additon, S.; Angelini, S.; Kymaelaeinen, O.; Salmassi, T. [California Univ., Santa Barbara, CA (United States). Center for Risk Studies and Safety

1996-10-01T23:59:59.000Z

151

In-vessel coolability and retention of a core melt. Volume 1  

SciTech Connect (OSTI)

The efficacy of external flooding of a reactor vessel as a severe accident management strategy is assessed for an AP600-like reactor design. The overall approach is based on the Risk Oriented Accident Analysis Methodology (ROAAM), and the assessment includes consideration of bounding scenarios and sensitivity studies, as well as arbitrary parametric evaluations that allow the delineation of the failure boundaries. Quantification of the input parameters is carried out for an AP600-like design, and the results of the assessment demonstrate that lower head failure is physically unreasonable. Use of this conclusion for any specific application is subject to verifying the required reliability of the depressurization and cavity-flooding systems, and to showing the appropriateness (in relation to the database presented here, or by further testing as necessary) of the thermal insulation design and of the external surface properties of the lower head, including any applicable coatings. The AP600 is particularly favorable to in-vessel retention. Some ideas to enhance the assessment basis as well as performance in this respect, for applications to larger and/or higher power density reactors are also provided.

Theofanous, T.G.; Liu, C.; Additon, S.; Angelini, S.; Kymaelaeinen, O.; Salmassi, T. [California Univ., Santa Barbara, CA (United States). Center for Risk Studies and Safety

1996-10-01T23:59:59.000Z

152

Gas retention and release behavior in Hanford single-shell waste tanks  

SciTech Connect (OSTI)

This report describes the current understanding of flammable gas retention and release in Hanford single-shell waste tanks based on theory, experimental results, and observations of tank behavior. The single-shell tanks likely to pose a flammable gas hazard are listed and described, and photographs of core extrusions and the waste surface are included. The credible mechanisms for significant flammable gas releases are described, and release volumes and rates are quantified as much as possible. The only mechanism demonstrably capable of producing large ({approximately}100 m{sup 3}) spontaneous gas releases is the buoyant displacement, which occurs only in tanks with a relatively deep layer of supernatant liquid. Only the double-shell tanks currently satisfy this condition. All release mechanisms believed plausible in single-shell tanks have been investigated, and none have the potential for large spontaneous gas releases. Only small spontaneous gas releases of several cubic meters are likely by these mechanisms. The reasons several other postulated gas release mechanisms are implausible or incredible are also given.

Stewart, C.W.; Brewster, M.E.; Gauglitz, P.A.; Mahoney, L.A.; Meyer, P.A.; Recknagle, K.P.; Reid, H.C.

1996-12-01T23:59:59.000Z

153

Preliminary Study of Strong-Sludge Gas Retention and Release Mechanisms in Clay Simulants  

SciTech Connect (OSTI)

The Hanford Site has 28 double-shell tanks (DSTs) and 149 single-shell tanks (SSTs) containing radioactive wastes that are complex mixes of radioactive and chemical products. The mission of the Department of Energys River Protection Project is to retrieve and treat the Hanford tank waste for disposal and close the tank farms. A key aspect of the mission is to retrieve and transfer waste from the SSTs, which are at greater risk for leaking, into DSTs for interim storage until the waste is transferred to and treated in the Waste Treatment and Immobilization Plant. There is, however, limited space in the existing DSTs to accept waste transfers from the SSTs, and approaches to overcoming the limited DST space will benefit the overall mission. The purpose of this study is to summarize and analyze the key previous experiment that forms the basis for the relaxed controls and to summarize initial progress and results on new experiments focused on understanding the conditions that result in low gas retention. The work is ongoing; this report provides a summary of the initial findings. The previous large-scale test used about 50 m3 of sediment, which would be unwieldy for doing multiple parametric experiments. Accordingly, experiments will begin with smaller-scale tests to determine whether the desired mechanisms can be studied without the difficulty of conducting very large experiments.

Gauglitz, Phillip A.; Buchmiller, William C.; Probert, Samuel G.; Owen, Antionette T.

2010-10-12T23:59:59.000Z

154

Evaluation of heterosis and heterosis retention in Bos taurus-Bos indicus crossbred cattle for productivity traits in cows  

E-Print Network [OSTI]

appreciation and gratitude to my committee chair, Dr. Sanders, and my committee members, Dr. Herring and Dr. Speed, who gave me support, guidance, and answers to my many questions from the moment I came to Texas A&M University. I would also like to thank my... of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE August 2005 Major Subject: Animal Breeding EVALUATION OF HETEROSIS AND HETEROSIS RETENTION IN BOS TAURUS -BOS INDICUS...

Meuchel, Meredith Christine

2005-11-01T23:59:59.000Z

155

In-Vessel Retention Technology Development and Use for Advanced PWR Designs in the USA and Korea  

SciTech Connect (OSTI)

In-Vessel Retention (IVR) of molten core debris by means of external reactor vessel flooding is a cornerstone of severe accident management for Westinghouse's AP600 (advanced passive light water reactor) design. The case for its effectiveness (made in previous work by the PI) has been thoroughly documented, reviewed as part of the licensing certification, and accepted by the US Nuclear Regulatory Commission. A successful IVR would terminate a severe accident, passively, with the core in a stable, coolable configuration (within the lower head), thus avoiding the largely uncertain accident evolution with the molten debris on the containment floor. This passive plant design has been upgraded by Westinghouse to the AP1000, a 1000 MWe plant very similar to the AP600. The severe accident management approach is very similar too, including In-Vessel Retention as the cornerstone feature, and initial evaluations indicated that this would be feasible at the higher power as well. A similar strategy is adopted in Korea for the APR1400 plant. The overall goal of this project is to provide experimental data and develop the necessary basic understanding so as to allow the robust extension of the AP600 In-Vessel Retention strategy for severe accident management to higher power reactors, and in particular, to the AP1000 advanced passive design.

T.G. Theofanous; S.J. Oh; J.H. Scobel

2004-05-18T23:59:59.000Z

156

Does UV disinfection compromise sutures? An evaluation of tissue response and suture retention in salmon surgically implanted with transmitters  

SciTech Connect (OSTI)

Ultraviolet radiation (UVR) can be used as a tool to disinfect surgery tools used for implanting transmitters into fish. However, the use of UVR could possibly degrade monofilament suture material used to close surgical incisions. This research examined the effect of UVR on monofilament sutures to determine if they were compromised and negatively influenced tag and suture retention, incision openness, or tissue reaction. Eighty juvenile Chinook salmon Oncorhynchus tshawytscha were surgically implanted with an acoustic transmitter and a passive integrated transponder. The incision was closed with a single stitch of either a suture exposed to 20 doses of UV radiation (5 minute duration per dose) or a new, sterile suture. Fish were then held for 28 d and examined under a microscope at day 7, 14, 21 and 28 for incision openness, ulceration, redness, and the presence of water mold. There was no significant difference between treatments for incision openness, redness, ulceration or the presence of water mold on any examination day. On day 28 post-surgery, there were no lost sutures; however, 2 fish lost their transmitters (one from each treatment). The results of this study do not show any differences in negative influences such as tissue response, suture retention or tag retention between a new sterile suture and a suture disinfected with UVR.

Walker, Ricardo W.; Brown, Richard S.; Deters, Katherine A.; Eppard, M. B.; Cooke, Steven J.

2013-10-01T23:59:59.000Z

157

Female Team Overall Name Age Rank Time Rank Time Rank Time Pace Rank Time Rank Time Pace Time  

E-Print Network [OSTI]

Female Team Overall Name Age Rank Time Rank Time Rank Time Pace Rank Time Rank Time Pace Time 1 Amy:56:27.6 Deborah Mc Eligot Deborah Storrings Male Team Overall Name Age Rank Time Rank Time Rank Time Pace Rank Time Rank Time Pace Time 1 Macon Fessenden 20 1 5:42.2 2 0:26.9 1 34:29.7 3:23 1 0:12.8 1 17:41.1 3

Suzuki, Masatsugu

158

EXPERIMENTAL STUDY OF CRITICAL HEAT FLUX WITH ALUMINA-WATER NANOFLUIDS IN DOWNWARD-FACING CHANNELS FOR IN-VESSEL RETENTION APPLICATIONS  

E-Print Network [OSTI]

The Critical Heat Flux (CHF) of water with dispersed alumina nanoparticles was measured for the geometry and flow conditions relevant to the In-Vessel Retention (IVR) situation which can occur during core melting sequences ...

Park, R.J.

159

Rethinking drug policy: an integrity preserving compromise position  

E-Print Network [OSTI]

Definition of Drug Types?????????????...??.. 4 2 Definition of Drug Scheduling??????????????. 5 1 CHAPTER I INTRODUCTION TO STATUS QUO DRUG POLICY The issue of how to properly regulate the use of illegal.... Legalizers are those who would make legal all currently illegal drugs. The most 3 common middle stance is that of harm reduction, which is ?an alternative approach to drug policy and treatment that focuses on minimizing the adverse effects of both...

Crispino, Azzurra

2006-10-30T23:59:59.000Z

160

Exhibit 1C Patent Rights-Retention by the Seller (Short Form) UT-B Contracts Div Page 1 of 3  

E-Print Network [OSTI]

Exhibit 1C ­ Patent Rights-Retention by the Seller (Short Form) UT-B Contracts Div Mar 2001 Page 1 of 3 ex1C-mar01format2005 Exhibit 1C Ref: DEAR 952.227-11 PATENT RIGHTS - RETENTION BY THE SELLER be patentable or otherwise protectable under title 35 of the United States Code, or any novel variety of plant

Pennycook, Steve

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Time Off  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassiveSubmittedStatus TomAboutManusScienceThe43068G. ThundatSmallDepartment ofTimTime

162

Data evaluation technical memorandum on the K-1407C Retention Basin at the Oak Ridge K-25 Site, Oak Ridge, Tennessee  

SciTech Connect (OSTI)

The K-1407-C Retention Basin was a surface impoundment at the Oak Ridge K-25 Site. The basin was used primarily for storing potassium hydroxide scrubber sludge generated at the K-25 Site. In addition, from 1960 to 1973, metal hydroxide sludges that were removed from the K-1407-B Holding Pond were discharged to the K-1407-C Retention Basin. The sludge in the K-1407-B Pond contained discharge from the K-1420 Decontamination and Uranium Recovery, the K-1501 Steam Plant, the K-1413 Laboratory, and the K-1401 Maintenance Building. Radioactive material is also present in the K-1407-C Retention Basin, probably the result of cleaning and decontamination activities at some of the aforementioned facilities. The discharge of waste materials to K-1407-C was discontinued before November of 1988, and all sludge was removed from the retention basin. Some of the sludge was stored, and the remainder was fixed in concrete. This report is specific to the K-1407-C Retention Basin and includes information pertinent to the evaluation of soil contamination. The focus of this evaluation is the effectiveness of the Phase 1 investigation of the K-1407-C Retention Basin to define site conditions adequately to support decisions regarding appropriate closure alternatives. This includes the physical characterization of the site area and the characterization of the nature and extent of contamination at the site in relation to risk characterization and statistical evaluation.

Beal, D.; Bock, J.; Hatmaker, T.; Zolyniak, J.; Goddard, P. (Oak Ridge K-25 Site, TN (United States)); Kucsmas, D. (Oak Ridge National Lab., TN (United States))

1991-10-01T23:59:59.000Z

163

Data evaluation technical memorandum on the K-1407C Retention Basin at the Oak Ridge K-25 Site, Oak Ridge, Tennessee. Environmental Restoration Program  

SciTech Connect (OSTI)

The K-1407-C Retention Basin was a surface impoundment at the Oak Ridge K-25 Site. The basin was used primarily for storing potassium hydroxide scrubber sludge generated at the K-25 Site. In addition, from 1960 to 1973, metal hydroxide sludges that were removed from the K-1407-B Holding Pond were discharged to the K-1407-C Retention Basin. The sludge in the K-1407-B Pond contained discharge from the K-1420 Decontamination and Uranium Recovery, the K-1501 Steam Plant, the K-1413 Laboratory, and the K-1401 Maintenance Building. Radioactive material is also present in the K-1407-C Retention Basin, probably the result of cleaning and decontamination activities at some of the aforementioned facilities. The discharge of waste materials to K-1407-C was discontinued before November of 1988, and all sludge was removed from the retention basin. Some of the sludge was stored, and the remainder was fixed in concrete. This report is specific to the K-1407-C Retention Basin and includes information pertinent to the evaluation of soil contamination. The focus of this evaluation is the effectiveness of the Phase 1 investigation of the K-1407-C Retention Basin to define site conditions adequately to support decisions regarding appropriate closure alternatives. This includes the physical characterization of the site area and the characterization of the nature and extent of contamination at the site in relation to risk characterization and statistical evaluation.

Beal, D.; Bock, J.; Hatmaker, T.; Zolyniak, J.; Goddard, P. [Oak Ridge K-25 Site, TN (United States); Kucsmas, D. [Oak Ridge National Lab., TN (United States)

1991-10-01T23:59:59.000Z

164

Comparison of Deuterium Retention for Ion-irradiated and Neutron-irradiated Tungsten  

SciTech Connect (OSTI)

The behavior of D retention for Fe{sup 2+}-irradiated tungsten with a damage of 0.025-3 dpa was compared with that for neutron-irradiated tungsten with 0.025 dpa. The D{sub 2} thermal desorption spectroscopy (TDS) spectra for Fe{sup 2+}-irradiated tungsten consisted of two desorption stages at 450 and 550 K, while that for neutron-irradiated tungsten was composed of three stages and an addition desorption stage was found at 750 K. The desorption rate of the major desorption stage at 550K increased as the displacement damage increased due to Fe{sup 2+} irradiation increasing. In addition, the first desorption stage at 450K was found only for damaged samples. Therefore, the second stage would be based on intrinsic defects or vacancy produced by Fe{sup 2+} irradiation, and the first stage should be the accumulation of D in mono-vacancy and the activation energy would be relatively reduced, where the dislocation loop and vacancy is produced. The third one was found only for neutron irradiation, showing the D trapping by a void or vacancy cluster, and the diffusion effect is also contributed to by the high full-width at half-maximum of the TDS spectrum. Therefore, it can be said that the D{sub 2} TDS spectra for Fe{sup 2+}-irradiated tungsten cannot represent that for the neutron-irradiated one, indicating that the deuterium trapping and desorption mechanism for neutron-irradiated tungsten is different from that for the ion-irradiated one.

Yasuhisa Oya; Masashi Shimada; Makoto Kobayashi; Takuji Oda; Masanori Hara; Hideo Watanabe; Yuji Hatano; Pattrick Calderoni; Kenji Okuno

2011-12-01T23:59:59.000Z

165

Pretreatment Nomogram to Predict the Risk of Acute Urinary Retention After I-125 Prostate Brachytherapy  

SciTech Connect (OSTI)

Purpose: Acute urinary retention (AUR) after iodine-125 (I-125) prostate brachytherapy negatively influences long-term quality of life and therefore should be prevented. We aimed to develop a nomogram to preoperatively predict the risk of AUR. Methods: Using the preoperative data of 714 consecutive patients who underwent I-125 prostate brachytherapy between 2005 and 2008 at our department, we modeled the probability of AUR. Multivariate logistic regression analysis was used to assess the predictive ability of a set of pretreatment predictors and the additional value of a new risk factor (the extent of prostate protrusion into the bladder). The performance of the final model was assessed with calibration and discrimination measures. Results: Of the 714 patients, 57 patients (8.0%) developed AUR after implantation. Multivariate analysis showed that the combination of prostate volume, IPSS score, neoadjuvant hormonal treatment and the extent of prostate protrusion contribute to the prediction of AUR. The discriminative value (receiver operator characteristic area, ROC) of the basic model (including prostate volume, International Prostate Symptom Score, and neoadjuvant hormonal treatment) to predict the development of AUR was 0.70. The addition of prostate protrusion significantly increased the discriminative power of the model (ROC 0.82). Calibration of this final model was good. The nomogram showed that among patients with a low sum score (<18 points), the risk of AUR was only 0%-5%. However, in patients with a high sum score (>35 points), the risk of AUR was more than 20%. Conclusion: This nomogram is a useful tool for physicians to predict the risk of AUR after I-125 prostate brachytherapy. The nomogram can aid in individualized treatment decision-making and patient counseling.

Roeloffzen, Ellen M., E-mail: e.m.a.roeloffzen@umcutrecht.nl [Department of Radiation Oncology, University Medical Center Utrecht (Netherlands); Vulpen, Marco van; Battermann, Jan J. [Department of Radiation Oncology, University Medical Center Utrecht (Netherlands); Roermund, Joep G. van [Department of Urology, University Medical Center Utrecht (Netherlands); Saibishkumar, Elantholi P. [Department of Radiation Oncology, Princess Margaret Hospital, Toronto, ON (Canada); Monninkhof, Evelyn M. [Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht (Netherlands)

2011-11-01T23:59:59.000Z

166

Mahanaxar: quality of service guarantees in high-bandwidth, real-time streaming data storage  

SciTech Connect (OSTI)

Large radio telescopes, cyber-security systems monitoring real-time network traffic, and others have specialized data storage needs: guaranteed capture of an ultra-high-bandwidth data stream, retention of the data long enough to determine what is 'interesting,' retention of interesting data indefinitely, and concurrent read/write access to determine what data is interesting, without interrupting the ongoing capture of incoming data. Mahanaxar addresses this problem. Mahanaxar guarantees streaming real-time data capture at (nearly) the full rate of the raw device, allows concurrent read and write access to the device on a best-effort basis without interrupting the data capture, and retains data as long as possible given the available storage. It has built in mechanisms for reliability and indexing, can scale to meet arbitrary bandwidth requirements, and handles both small and large data elements equally well. Results from our prototype implementation shows that Mahanaxar provides both better guarantees and better performance than traditional file systems.

Bigelow, David [Los Alamos National Laboratory; Bent, John [Los Alamos National Laboratory; Chen, Hsing - Bung [Los Alamos National Laboratory; Brandt, Scott [UCSC

2010-01-01T23:59:59.000Z

167

Drug Innovation "Bridging Molecules and Diseases"  

E-Print Network [OSTI]

in the pharmaceutical industry. This focus area wishes to provide a knowledge and expertise platform, which platforms with the pharmaceutical industry are presently organized at three different levels: - Strategic, that allows high-level concerted drug research efforts in the molecular sciences, pharmaceutical sciences

Utrecht, Universiteit

168

Drug smuggling safety tests [July 1, 2006  

E-Print Network [OSTI]

enough to be utilized as drug carriers. Suslick adds that the three tests on mammalian cells they carried evidence of nano safety Login | Register Search: Site X-Ray Page 1 of 2X-Ray - Your Guide to All the Key X About Us | Contact Us | Privacy Policy | Terms & Conditions | Advertising | RSS Interested

Suslick, Kenneth S.

169

Results of Large-Scale Testing on Effects of Anti-Foam Agent on Gas Retention and Release  

SciTech Connect (OSTI)

The U.S. Department of Energy (DOE) Office of River Protections Waste Treatment Plant (WTP) will process and treat radioactive waste that is stored in tanks at the Hanford Site. The waste treatment process in the pretreatment facility will mix both Newtonian and non-Newtonian slurries in large process tanks. Process vessels mixing non-Newtonian slurries will use pulse jet mixers (PJMs), air sparging, and recirculation pumps. An anti-foam agent (AFA) will be added to the process streams to prevent surface foaming, but may also increase gas holdup and retention within the slurry. The work described in this report addresses gas retention and release in simulants with AFA through testing and analytical studies. Gas holdup and release tests were conducted in a 1/4-scale replica of the lag storage vessel operated in the Pacific Northwest National Laboratory (PNNL) Applied Process Engineering Laboratory using a kaolin/bentonite clay and AZ-101 HLW chemical simulant with non-Newtonian rheological properties representative of actual waste slurries. Additional tests were performed in a small-scale mixing vessel in the PNNL Physical Sciences Building using liquids and slurries representing major components of typical WTP waste streams. Analytical studies were directed at discovering how the effect of AFA might depend on gas composition and predicting the effect of AFA on gas retention and release in the full-scale plant, including the effects of mass transfer to the sparge air. The work at PNNL was part of a larger program that included tests conducted at Savannah River National Laboratory (SRNL) that is being reported separately. SRNL conducted gas holdup tests in a small-scale mixing vessel using the AZ-101 high-level waste (HLW) chemical simulant to investigate the effects of different AFAs, their components, and of adding noble metals. Full-scale, single-sparger mass transfer tests were also conducted at SRNL in water and AZ-101 HLW simulant to provide data for PNNLs WTP gas retention and release modeling.

Stewart, Charles W.; Guzman-Leong, Consuelo E.; Arm, Stuart T.; Butcher, Mark G.; Golovich, Elizabeth C.; Jagoda, Lynette K.; Park, Walter R.; Slaugh, Ryan W.; Su, Yin-Fong; Wend, Christopher F.; Mahoney, Lenna A.; Alzheimer, James M.; Bailey, Jeffrey A.; Cooley, Scott K.; Hurley, David E.; Johnson, Christian D.; Reid, Larry D.; Smith, Harry D.; Wells, Beric E.; Yokuda, Satoru T.

2008-01-03T23:59:59.000Z

170

May 21, 2012, Office of Health, Safety and Security (HSS) Focus Group Work Force Retention Work Group Charter  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion | Department of EnergyDevelopment AccidentEnergyBioenergy16-11 HSSWork Force Retention

171

Alignment strategies for drug product process development and manufacturing  

E-Print Network [OSTI]

The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the product-process interaction ...

Garvin, Christopher John

2012-01-01T23:59:59.000Z

172

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

173

Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs  

E-Print Network [OSTI]

Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

Stauber, Zachary Jason

2012-01-01T23:59:59.000Z

174

Research paper Drug diffusion and binding in ionizable interpenetrating networks  

E-Print Network [OSTI]

Research paper Drug diffusion and binding in ionizable interpenetrating networks from poly) (PVA), poly(acrylic acid) (PAA), and their interpenetrating networks (IPNs) were prepared using by measuring their equilibrium polymer volume fraction, equilibrium swelling ratio, and mesh size. Drug

Peppas, Nicholas A.

175

High throughput optical sensor arrays for drug screening  

E-Print Network [OSTI]

In the world of drug discovery, high throughput whole cell assays are a critical step in discovering therapeutically relevant drug compounds [1]. This report details the development of several novel sensor systems capable ...

Harjes, Daniel I

2006-01-01T23:59:59.000Z

176

Luminal flow amplifies stent-based drug deposition in arterial  

E-Print Network [OSTI]

Background: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely ...

Levine, Evan G.

177

Specific and general binding in arterial drug delivery  

E-Print Network [OSTI]

Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

Levin, Andrew D. (Andrew David), 1976-

2005-01-01T23:59:59.000Z

178

Attitudes toward the integration of smoking cessation treatment into drug abuse clinics.  

E-Print Network [OSTI]

Direct Care Workforce in the National Drug Abuse Treatmentdependence treatment into drug abuse care reduces thesecare settings but not yet in independent drug abuse treatment

2007-01-01T23:59:59.000Z

179

E-Print Network 3.0 - arv drug patents Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... country Generic name Non proprietary, same...

180

E-Print Network 3.0 - anticancer drug levels Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Chemistry 7 Oxford University Press 2005 1 Discovering drug interactions: a text-mining and reasoning ap- Summary: is responsible for metabol- ism of drug B. Such drug...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

E-Print Network 3.0 - anticancer drug topotecan Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

182

E-Print Network 3.0 - anticancer drug combretastatin-a2 Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

183

E-Print Network 3.0 - anticancer drug oracin Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

184

E-Print Network 3.0 - anticancer drugs mitoxantrone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

185

E-Print Network 3.0 - anticancer drug roscovitine Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

186

E-Print Network 3.0 - anticancer drug mitoxantrone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

187

E-Print Network 3.0 - antiretroviral drugs arvs Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(ARV) drugs except... . Assessment of a pilot antiretroviral drug therapy programme in Uganda: patients' response, survival, and drug... 1 Early loss to program in HIV-infected ......

188

E-Print Network 3.0 - analyzing drug combination Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

, Saadat Anwar2 , Shanshan Liang2... : Identifying drug-drug interactions is a critical process in drug administration and ... Source: Baral, Chitta - Department of Computer...

189

E-Print Network 3.0 - antiviral drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Opin Emerg Drugs . Author manuscript Emerging drugs for hepatitis B Summary: and to design new trials of combination therapy to delay drug resistance. In the future, antiviral...

190

PET IMAGING STUDIES IN DRUG ABUSE RESEARCH.  

SciTech Connect (OSTI)

There is overwhelming evidence that addiction is a disease of the brain (Leshner, 1997). Yet public perception that addiction is a reflection of moral weakness or a lack of willpower persists. The insidious consequence of this perception is that we lose sight of the fact that there are enormous medical consequences of addiction including the fact that a large fraction of the total deaths from cancer and heart disease are caused by smoking addiction. Ironically the medical school that educates physicians in addiction medicine and the cancer hospital that has a smoking cessation clinic are vanishingly rare and efforts at harm reduction are frequently met with a public indignation. Meanwhile the number of people addicted to substances is enormous and increasing particularly the addictions to cigarettes and alcohol. It is particularly tragic that addiction usually begins in adolescence and becomes a chronic relapsing problem and there are basically no completely effective treatments. Clearly we need to understand how drugs of abuse affect the brain and we need to be creative in using this information to develop effective treatments. Imaging technologies have played a major role in the conceptualization of addiction as a disease of the brain (Fowler et al., 1998a; Fowler et al., 1999a). New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology and medicine. This topic cuts across the medical specialties of neurology, psychiatry, cancer and heart disease because of the high medical, social and economic toll that drugs of abuse, including and especially the legal drugs, cigarettes and alcohol, take on society. In this chapter we will begin by highlighting the important role that chemistry has played in making it possible to quantitatively image the movement of drugs as well as their effects on the human brain. This will be followed by highlights of PET studies of the acute effects of the psychostimulant drugs cocaine and methylphenidate (ritalin) and studies of the chronic effects of cocaine and of tobacco smoke on the human brain. This chapter concludes with the description of a study which uses brain imaging coupled with a specific pharmacological challenge to address the age-old question of why some people who experiment with drugs become addicted while others do not.

Fowler, J.S.; Volkow, N.D.; Ding, Y.S.; Logan, J.; Wang, G.J.

2001-01-29T23:59:59.000Z

191

Proper Usage of Drugs and Chemicals in Food Animals  

E-Print Network [OSTI]

of omission or commission, violative residues in livestock and poultry (by irresponsible and illegal distribution and use of drugs) violates state and federal laws. When FSIS inspectors detect violative drug residues in food products derived from ani- mals... quality ani- mal food products. Extra-label distribution, prescription and use of veterinary drugs in food producing animals are reg- ulated by FDA. The FDA policy requires all extra- label drug usage to be under the control of a licensed veterinarian...

Faries Jr., Floron C.

2002-02-15T23:59:59.000Z

192

Retention and management of stormwater runoff with rain gardens and rainwater harvesting systems.  

E-Print Network [OSTI]

??The alteration of natural flow regimes associated with land use change increases the volume of stormwater runoff and peak flows, and reduces the time to (more)

Schlea, Derek Alan

2011-01-01T23:59:59.000Z

193

Model-Based Dependability Analysis of Programmable Drug Infusion Pumps  

E-Print Network [OSTI]

Model-Based Dependability Analysis of Programmable Drug Infusion Pumps Sriram Sankaranarayanan.lastname@colorado.edu Abstract. Infusion pumps are commonly used in home/hospital care to inject drugs into a patient a case-study involving an infusion pump used to manage pain through the infusion of analgesic drugs

Sankaranarayanan, Sriram

194

Drug-Free Federal Workplace Testing Implementation Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The order provides guidance and policy for the administration, application and implementation of the DOE Drug-free Federal Workplace Plan and other regulations that facilitate the maintenance of a drug-free Federal workplace through the establishment of programs to test for the use of illegal drugs. Chg 1, dated 8-21-92

1988-07-29T23:59:59.000Z

195

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network [OSTI]

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

196

Optically generated ultrasound for enhanced drug delivery  

DOE Patents [OSTI]

High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

2002-01-01T23:59:59.000Z

197

From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement  

E-Print Network [OSTI]

reputation-2009-2). Carter, Jimmy. 1977. Drug Abuse Messagea presidential candidate in 1976, Jimmy Carter even adopted

Heddleston, Thomas Reed

2012-01-01T23:59:59.000Z

198

Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery  

E-Print Network [OSTI]

Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to ...

Seto, Jennifer Elizabeth

2011-01-01T23:59:59.000Z

199

TECHNETIUM RETENTION IN WTP LAW GLASS WITH RECYCLE FLOW-SHEET DM10 MELTER TESTING VSL-12R2640-1 REV 0  

SciTech Connect (OSTI)

Melter tests were conducted to determine the retention of technetium and other volatiles in glass while processing simulated Low Activity Waste (LAW) streams through a DM10 melter equipped with a prototypical off-gas system that concentrates and recycles fluid effiuents back to the melter feed. To support these tests, an existing DM10 system installed at Vitreous State Laboratory (VSL) was modified to add the required recycle loop. Based on the Hanford Tank Waste Treatment and Immobilization Plant (WTP) LAW off-gas system design, suitably scaled versions of the Submerged Bed Scrubber (SBS), Wet Electrostatic Precipitator (WESP), and TLP vacuum evaporator were designed, built, and installed into the DM10 system. Process modeling was used to support this design effort and to ensure that issues associated with the short half life of the {sup 99m}Tc radioisotope that was used in this work were properly addressed and that the system would be capable of meeting the test objectives. In particular, this required that the overall time constant for the system was sufficiently short that a reasonable approach to steady state could be achieved before the {sup 99m}Tc activity dropped below the analytical limits of detection. The conceptual design, detailed design, flow sheet development, process model development, Piping and Instrumentation Diagram (P&ID) development, control system design, software design and development, system fabrication, installation, procedure development, operator training, and Test Plan development for the new system were all conducted during this project. The new system was commissioned and subjected to a series of shake-down tests before embarking on the planned test program. Various system performance issues that arose during testing were addressed through a series of modifications in order to improve the performance and reliability of the system. The resulting system provided a robust and reliable platform to address the test objectives.

Abramowitz, Howard [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Brandys, Marek [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Cecil, Richard [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; D'Angelo, Nicholas [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Matlack, Keith S. [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Muller, Isabelle S. [Catholic Univ. of America, Washington, DC (United States). Vitreous State Lab.; Pegg, Ian L. [Energy Solutions, Federal EPC, Inc., Columbia, MD (United States); Callow, Richard A. [Energy Solutions, Federal EPC, Inc., Columbia, MD (United States); Joseph, Innocent

2012-12-11T23:59:59.000Z

200

Extension of the Isobolographic Approach to Interactions Studies between More than Two Drugs: Illustration  

E-Print Network [OSTI]

received the drugs separately or in various combinations. Drug infusion was stopped at the onset of maximal

Gelman, Andrew

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Hyperpolarized Nanodiamond with Long Spin Relaxation Times  

E-Print Network [OSTI]

The use of hyperpolarized agents in magnetic resonance (MR), such as 13C-labeled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarizaton technique is the inherently short spin relaxation times, typically solid-state environment, exhibit relaxation times exceeding 1 hour. Combined with the already established applications of NDs in the life-sciences as inexpensive fluorescent markers and non-cytotoxic substrates for gene and drug delivery, these results extend the theranostic capabilities of nanoscale diamonds into the domain of hyperpolarized MR.

Ewa Rej; Torsten Gaebel; Thomas Boele; David E. J. Waddington; David J. Reilly

2015-02-22T23:59:59.000Z

202

DRUG TESING PANEL & CUTOFF CONCENTRATIONS  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phases onOrganizationElectronic2005-2007 Budget Dear2, 2011DREAM toolDRUG

203

Final Report - Gas Retention and Release Tests Supporting the Concentrate Receipt Vessel (CRV-VSL-00002A/2B) Configuration  

SciTech Connect (OSTI)

Gas Retention and Release (GR and R) tests were performed in the scaled Concentrate Receipt Vessel (CRV) Test Stand at the Savannah River National Laboratory to validate the capability of candidate Hybrid-Mixing systems for the CRV to safely release hydrogen during normal and upset conditions. Hydrogen is generated in the radioactive waste as a result of natural and plant processes and must not be allowed to accumulate above flammability limits. Two types of tests were conducted. Gas holdup tests determined the steady state amount of gas accumulated in the simulant under normal PJM only or PJM plus sparging conditions. Gas release tests determined what operating conditions are necessary to fully release gas after a steady state gas fraction of 4 per cent tank volume or more was reached in the simulant.

GUERRERO, HECTOR

2004-09-01T23:59:59.000Z

204

A pulsed field gradient and NMR imaging investigations of the water retention mechanism by cellulose ethers in mortars  

SciTech Connect (OSTI)

The study presented in this paper is devoted to improve the knowledge on the influence of cellulose ethers (CE) on the freshly-mixed mortars water retention. Indeed, this crucial property is the most important imparted by these polysaccharides. One of the assumptions proposed to explain this phenomenon is that CE acts as diffusion barrier to the water. To test this hypothesis, the CE effect on the self-diffusion coefficient of water in solution and on the water mobility between two fresh cement pastes was studied by Nuclear Magnetic Resonance. CE does not significantly modify the water self-diffusion coefficient in CE solution or in admixed cement pastes. Moreover the interdiffusion imaging experiments demonstrated that the water diffusion at the paste/paste interface is not affected by the presence of cellulosic admixture.

Patural, Laetitia, E-mail: patural@emse.f [Ecole Nationale Superieure des Mines de Saint-Etienne, Centre SPIN, LPMG UMR 5148, 158 cours Fauriel, F-42023 Saint-Etienne Cedex 2 (France); Porion, Patrice [Centre de la Recherche sur la Matiere Divisee, CNRS-Universite d'Orleans, UMR 6619, 1b rue de la Ferollerie, F-45071 Orleans Cedex 2 (France); Van Damme, Henri [Laboratoire de Physico-chimie des Polymeres et Milieux Disperses, ESPCI ParisTech, 10 rue Vauquelin, F-75231 Paris Cedex 05 and Universite Paris Est - LCPC, 58 boulevard Lefebvre, 75732 Paris cedex 15 (France); Govin, Alexandre; Grosseau, Philippe [Ecole Nationale Superieure des Mines de Saint-Etienne, Centre SPIN, LPMG UMR 5148, 158 cours Fauriel, F-42023 Saint-Etienne Cedex 2 (France); Ruot, Bertrand; Deves, Olivier [Universite Paris-Est, Centre Scientifique et Technique du Batiment, Departement Enveloppe et Revetements/Division Enduits, Mortiers et Colles, 84 avenue Jean Jaures, F-77447 Marne-la-Vallee Cedex 2 (France)

2010-09-15T23:59:59.000Z

205

Nonequilibrium sulfur capture and retention in an air cooled slagging coal combustor. Quarterly technical progress report, 1996  

SciTech Connect (OSTI)

The objective of this 24 month project is to determine the degree of sulfur retention in slag in a full scale cyclone coal combustor with sulfur capture by calcium oxide sorbent injection into the combustor. This sulfur capture process consists of two steps: Capture of sulfur with calcined calcium oxide followed by impact of the reacted sulfur-calcium particles on the liquid slag lining the combustor. The sulfur bearing slag must be removed within several minutes from the combustor to prevent re-evolution of the sulfur from the slag. To accomplish this requires slag mass flow rates in the range of several 100 lb/hr. To study this two step process in the combustor, two groups of tests are being implemented. In the first group, calcium sulfate in the form of gypsum, or plaster of Paris, was injected in the combustor to determine sulfur evolution from slag. In the second group, the entire process is tested with limestone and/or calcium hydrate injected into the combustor. This entire effort consists of a series of up to 16 parametric tests in a 20 MMtu/hr slagging, air cooled, cyclone combustor. During the present quarterly reporting period ending September 30,1996, three tests in this project were implemented, bringing the total tests to 5. In addition, a total of 10 test days were completed during this quarter on the parallel project that utilizes the same 20 MMtu/hr combustor. The results of that project, especially those related to improved slagging performance, have a direct bearing on this project in assuring proper operation at the high slag flow rates that may be necessary to achieve high sulfur retention in slag.

Zauderer, B.

1996-11-01T23:59:59.000Z

206

Print Date: 6/30/2003 The Effects of Advertising on Customer Retention  

E-Print Network [OSTI]

. We propose a two-period model in which an auctioneer sells one item in each time period using, since the higher the number of bidders, the higher the expected winning price and profitability in the auction. It is this tradeoff for the auctioneer between more consumers and a higher expected price versus

Faloutsos, Christos

207

Above- and below-ground Litter Manipulation: Effect on Retention and Release of DOC, DON and DIN in the Sikfokut Forest, Hungary  

E-Print Network [OSTI]

on the retention and release of dissolved organic carbon (DOC), dissolved organic nitrogen (DON), nitrate and ammonium in the soil profile at 0-5 and 5-15 cm depths. The soils were obtained from a Long Term Ecological Research site in the Sikfokut Forest in Hungary...

Evetts, Elizabeth A.; Peterson, Jacqueline A.

2009-09-30T23:59:59.000Z

208

Alcohol, Drugs, and Accident Prevention (RC-371/-571) Course Description The role of alcohol and drugs and their relationship to accident causation will be examined. The problem  

E-Print Network [OSTI]

Alcohol, Drugs, and Accident Prevention (RC-371/-571) Course Description The role of alcohol and drugs and their relationship to accident causation will be examined. The problem of alcoholism and drug

Wu, Mingshen

209

Improving cancer treatment with cyclotron produced radionuclides. [Multiple Drug Resistance (MDR)  

SciTech Connect (OSTI)

The overall objective of this work was to promote nuclear medicine applications in oncology. This is being done by improving the scientific basis of diagnosis, treatment and treatment follow-up with cyclotron-produced tracers. For diagnostic use, positron-emitting isotopes such as Ga-66 and I-124 are being used. Initial studies on the characterization of He-4 particle energies required for Ga-66 production have been completed. Parameters for I-124 radiolabelling of monoclonal antibodies have been determined; the labelled antibodies have been used in animal studies using positron emission tomography (PET) to quantify antibody concentration within tumors in vivo. Imaging physics studies have demonstrated that I-124 can be quantitatively imaged by PET, even in the presence of 100-told greater concentrations of I-131. Measurement of concentrations of label in vivo has been accomplished in nuclei mice bearing neuroblastoma tumors and nude rats bearing human ovarian cancer cells. These studies have major implications for both the quantification of dosimetry and quantification kinetic assessment of anti-tumor antibody localization in vivo. For treatment of tumors, F-18 has been incorporated in 2-fluoro-2-deoxy glucose and 5-fluoro uridine, and O-15 labelled water has been produced. Reagents incorporating C-11 and N-13 are under development. In a related area, C-14 labelled colchicine is being studied as a means of assaying cells for multiple drug resistance (MDR). Cells expressing MDR are shown to retain significantly less C-14 colchiene. This suggest that colchiene retention may be of useful probe in modelling and studying MDR development in human tumors. The precursor required for producing C-11 colchicine has also been synthesized. 11 refs. (MHB)

Larson, S.M.; Finn, R.D.

1990-10-15T23:59:59.000Z

210

Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells  

SciTech Connect (OSTI)

Celecoxib, an inhibitor of cyclooxygenase-2, is being investigated for enhancement of chemotherapy efficacy in cancer clinical trials. This study investigates the ability of cyclooxygenase-2 inhibitors to sensitize cells from different origins to several chemotherapeutic agents. The effect of the drug's mechanism of action and sequence of administration are also investigated. The sensitivity, cell cycle, apoptosis and DNA damage of five different cancer cell lines (HeLa, HCT116, HepG2, MCF7 and U251) to 5-FU, cisplatin, doxorubicin and etoposide {+-} celecoxib following different incubation schedules were analyzed. We found antagonism between celecoxib and the four drugs in the breast cancer cells MCF7 following all incubation schedules and between celecoxib and doxorubicin in all cell lines except for two combinations in HCT116 cells. Celecoxib with the other three drugs in the remaining four cell lines resulted in variable interactions. Mechanistic investigations revealed that celecoxib exerts different molecular effects in different cells. In some lines, it abrogates the drug-induced G2/M arrest enhancing pre-mature entry into mitosis with damaged DNA thus increasing apoptosis and resulting in synergism. In other cells, it enhances drug-induced G2/M arrest allowing time to repair drug-induced DNA damage before entry into mitosis and decreasing cell death resulting in antagonism. In some synergistic combinations, celecoxib-induced abrogation of G2/M arrest was not associated with apoptosis but permanent arrest in G1 phase. These results, if confirmed in-vivo, indicate that celecoxib is not a suitable chemosensitizer for breast cancer or with doxorubicin for other cancers. Moreover, combination of celecoxib with other drugs should be tailored to the tumor type, drug and administration schedule. - Graphical abstract: Display Omitted Highlights: > Celecoxib may enhance effects of anticancer drugs. > Its combination with four drugs was tested in five cancer cell lines. > It antagonized the effects of the four drugs in the breast cancer cell line MCF7. > Doxorubicin's cytotoxic effects were antagonized by celecoxib in four cell lines. > Cell cycle, apoptosis and DNA damage explain the different interactive effects.

El-Awady, Raafat A., E-mail: relawady@sharjah.ac.ae [Pharmacology unit, Department of Cancer Biology, National, Cancer Institute, Cairo University, Fom El-Khalig, Cairo (Egypt); Department of Pharmacology and Pharmaceutics, College of Pharmacy, University of Sharjah, University City road, 27272 Sharjah (United Arab Emirates); Saleh, Ekram M. [Clinical Biochemistry and Molecular Biology unit, Department of Cancer Biology, National, Cancer Institute, Cairo University, Fom El-Khalig, Cairo (Egypt); Ezz, Marwa [College of Pharmacy, Cairo University, Cairo (Egypt); Elsayed, Abeer M. [Tissue Culture unit, Pathology Department, National Cancer Institute, Cairo University (Egypt)

2011-09-15T23:59:59.000Z

211

antidepressant drug treatment: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

prognosis. ... Scott, Alexander Wesley 2010-01-01 50 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

212

antiretroviral drug exposure: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

SKILLS AQUIRED THROUGH Auerbach, Scott M. 2 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

213

antiretroviral drug combination: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

carrying various combinations Ahlers, Guenter 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

214

antidepressant drug design: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ylenedioxymethamphetamine (MDMA) also known as Ecstasy is a common recreational drug of abuse and reports of abuse of tricyclic antidepressants are also known. We report two cases...

215

Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs  

E-Print Network [OSTI]

Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

Wu, Peter I-Kung

2007-01-01T23:59:59.000Z

216

In silico modeling to predict drug-induced phospholipidosis  

SciTech Connect (OSTI)

Drug-induced phospholipidosis (DIPL) is a preclinical finding during pharmaceutical drug development that has implications on the course of drug development and regulatory safety review. A principal characteristic of drugs inducing DIPL is known to be a cationic amphiphilic structure. This provides evidence for a structure-based explanation and opportunity to analyze properties and structures of drugs with the histopathologic findings for DIPL. In previous work from the FDA, in silico quantitative structureactivity relationship (QSAR) modeling using machine learning approaches has shown promise with a large dataset of drugs but included unconfirmed data as well. In this study, we report the construction and validation of a battery of complementary in silico QSAR models using the FDA's updated database on phospholipidosis, new algorithms and predictive technologies, and in particular, we address high performance with a high-confidence dataset. The results of our modeling for DIPL include rigorous external validation tests showing 8081% concordance. Furthermore, the predictive performance characteristics include models with high sensitivity and specificity, in most cases above ? 80% leading to desired high negative and positive predictivity. These models are intended to be utilized for regulatory toxicology applied science needs in screening new drugs for DIPL. - Highlights: New in silico models for predicting drug-induced phospholipidosis (DIPL) are described. The training set data in the models is derived from the FDA's phospholipidosis database. We find excellent predictivity values of the models based on external validation. The models can support drug screening and regulatory decision-making on DIPL.

Choi, Sydney S.; Kim, Jae S.; Valerio, Luis G., E-mail: luis.valerio@fda.hhs.gov; Sadrieh, Nakissa

2013-06-01T23:59:59.000Z

217

Unlocking enzyme synthesis of rare sugars to create drugs with...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

this study is to dramatically improve the performance of enzymes that can be used by the pharmaceutical industry to synthesize drug precursors," said ORNL's Andrey Kovalevsky, the...

218

antimalarial drug artemisinin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Isolation of Artemisinin as Antimalarial Drugs from Artemisia annua L. Cultivated in Indonesia CiteSeer Summary: Abstract-- Malaria disease is endemic in developing countries like...

219

act drug policies: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of alcoholic beverages. These standards conform to state and federal laws. The policy described in this brochure pertains to alcohol and other drug use behaviors in...

220

antithyroid drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

antidiabetic drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

222

antiretroviral drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

223

antipsychotic drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

224

adverse drug events: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

225

adverse drug event: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

226

antiepileptic drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

227

antiarrhythmic drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

228

acute drug intoxication: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

229

adhd drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

230

antihypertensive drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

231

Transdermal microconduits by microscission for drug delivery and sample acquisition  

E-Print Network [OSTI]

Background Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum ...

Gonzalez, Salvador

232

Food and Drug Administration White Oak Campus Environmental Stewardshi...  

Broader source: Energy.gov (indexed) [DOE]

FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus. espcsswhiteoak.pdf More Documents & Publications Energy...

233

antimalarial drug development: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 30 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

234

antidepressant drug development: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 39 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

235

avoiding drug development: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 23 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

236

Intracellular drug distribution-based targeting: Exploiting lysosomes to enhance the selectivity of drugs towards cancer cells  

E-Print Network [OSTI]

was found to induce marked tumor regression. The discovery of nitrogen mustard as a novel anticancer drug resulted in a great deal of optimism that cancer could finally be cured. A burst of research activity to develop new anticancer drugs therefore... of activity against normal cells. Indeed, many novel anticancer agents continue to be identified, but few find clinical utility due to unacceptable toxicity [17], a clear indicator that there is a need for a screening approach that can identify potent drugs...

Ndolo, Rosemary A.

2012-08-31T23:59:59.000Z

237

Precision Timed Machines  

E-Print Network [OSTI]

1.4 Precision Timed Machines . . . . .Precision Timed Machine 2.1precision timed (PRET) machine. pages 264265, June 2007. [

Liu, Isaac Suyu

2012-01-01T23:59:59.000Z

238

Drug-Free Federal Workplace Testing Implementation Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The subject directive provides requirements and responsibilities for the implementation of a workplace program to test for the use of illegal drugs to facilitate the maintenance of a drug-free Federal workplace. In the course of the revision, the document number will change from DOE O 3792.3 to DOE O 343.1.

2012-12-06T23:59:59.000Z

239

ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY  

E-Print Network [OSTI]

are more related to the kind of cancer than to drug activity patterns. Dependency analysis using Bayesian1 11 ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY CLUSTERING AND BAYESIAN of data produced from up- to-date biological experimental processes needs appropriate data mining

240

Identifying novel drug indications through automated reasoning Authors and Affiliations  

E-Print Network [OSTI]

of these drugs have potential anti-cancer activities based on information on their targets and molecular discovery, text mining, automated reasoning Abstract Background With the large amount of pharmacological interaction types alone. A total of 507 drugs were found to have the potential to be used for cancer

Baral, Chitta

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance  

E-Print Network [OSTI]

Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance J. J. Westman-7045 USA Abstract A compartment model for the evolution of cancer subject to multiple chemotherapeutic agents is presented. The formulation accounts for the heterogeneous nature of cancer and drug resistance

Hanson, Floyd B.

242

Charge Retention by Gold Clusters on Surfaces Prepared Using Soft Landing of Mass Selected Ions  

SciTech Connect (OSTI)

Monodisperse gold clusters have been prepared on surfaces in different charge states through soft landing of mass-selected ions. Ligand-stabilized gold clusters were prepared in methanol solution by reduction of chloro(triphenylphosphine)gold(I) with borane tert-butylamine complex in the presence of 1,3-bis(diphenylphosphino)propane. Electrospray ionization was used to introduce the clusters into the gas-phase and mass-selection was employed to isolate a single ionic cluster species (Au11L53+, L = 1,3-bis(diphenylphosphino)propane) which was delivered to surfaces at well controlled kinetic energies. Using in-situ time of flight secondary ion mass spectrometry (TOF-SIMS) it is demonstrated that the Au11L53+ cluster retains its 3+ charge state when soft landed onto the surface of a 1H,1H,2H,2H-

Johnson, Grant E.; Priest, Thomas A.; Laskin, Julia

2012-01-24T23:59:59.000Z

243

Blue MedicareRx (PDP)SM 2012 Comprehensive Drug List  

E-Print Network [OSTI]

Blue MedicareRx (PDP)SM 2012 Comprehensive Drug List PLEASE READ: THIS DOCUMENT CONTAINS DrugList Blue MedicareRx (PDP)SM 2012 Formulary (List of Covered Drugs) DrugList PLEASE READ. Blue MedicareRx (PDP) is a stand-alone prescription drug plan with a Medicare contract offered by HCSC

Oklahoma, University of

244

Hypoxic cell radiosensitizers: expectations and progress in drug development  

SciTech Connect (OSTI)

When misonidazole (MISO) was introduced into clinical trials there were great expectations that the cure rate of many tumors would be dramatically increased. The lack of efficacy of MISO discouraged further studies with hypoxic cell sensitizers. In recent years superior sensitizers SR 2508 and RO-03-8799 have been introduced into the clinic. SR 2508 is less neurotoxic than MISO, allowing more than three times the total amount of drug to be administered. Furthermore, based on the analysis of a patient's plasma pharmacokinetic profile, neurotoxicity may be largely avoidable. RO-03-8799 is superior in that it produces a higher sensitizer enhancement ratio than MISO for the same administered dose. Unlike with MISO and SR 2508, the dose of RO-03-8799 that can be administered is limited by acute toxicity with no cumulative toxicity having yet been encountered. Study design has improved and the expected clinical benefit from sensitizers has been clarified. Sensitizers, like particle radiation therapy and hyperthemia will, if successful, effect the rate of local tumor control, but cannot improve the cure rate of patients with preexisting metastatic disease. Taking into account the need to optimize reoxygenation, the various reasons for tumor radioresistance other than hypoxia, and the lower oxygen and sensitizer enhancement ratios at 200 cGy per fraction, it is likely that sensitizers will provide some clinical benefit for patients with selected tumor types.

Coleman, C.N.

1985-02-01T23:59:59.000Z

245

An alternative approach based on microfluidics to study drug metabolism and toxicity using liver and intestinal tissue.  

E-Print Network [OSTI]

??A new in vitro system has been developed to study drug metabolism, drug-drug interactions and interorgan communication. As the ultimate goal was a system which (more)

Midwoud, Paul Marcel van

2010-01-01T23:59:59.000Z

246

Dissolved Nutrient Retention Dynamics in River Networks: A Modeling Investigation of Transient Flow and Scale Effects  

SciTech Connect (OSTI)

In this paper, we use a dynamic network flow model, coupled with a transient storage zone biogeochemical model, to simulate dissolved nutrient removal processes at the channel network scale. We have explored several scenarios in respect of the combination of rainfall variability, and the biological and geomorphic characteristics of the catchment, to understand the dominant controls on removal and delivery of dissolved nutrients (e.g., nitrate). These model-based theoretical analyses suggested that while nutrient removal efficiency is lower during flood events compared to during baseflow periods, flood events contribute significantly to bulk nutrient removal, whereas bulk removal during baseflow periods is less. This is due to the fact that nutrient supply is larger during flood events; this trend is even stronger in large rivers. However, the efficiency of removal during both periods decreases in larger rivers, however, due to (i) increasing flow velocities and thus decreasing residence time, and (ii) increasing flow depth, and thus decreasing nutrient uptake rates. Besides nutrient removal processes can be divided into two parts: in the main channel and in the hyporheic transient storage zone. When assessing their relative contributions the size of the transient storage zone is a dominant control, followed by uptake rates in the main channel and in the transient storage zone. Increasing size of the transient storage zone with downstream distance affects the relative contributions to nutrient removal of the water column and the transient storage zone, which also impacts the way nutrient removal rates scale with increasing size of rivers. Intra-annual hydrologic variability has a significant impact on removal rates at all scales: the more variable the streamflow is, compared to mean discharge, the less nutrient is removed in the channel network. A scale-independent first order uptake coefficient, ke, estimated from model simulations, is highly dependent on the relative size of the transient storage zone and how it changes in the downstream direction, as well as the nature of hydrologic variability.

Ye, Sheng; Covino, Timothy P.; Sivapalan, Murugesu; Basu, Nandita; Li, Hongyi; Wang, Shaowen

2012-06-30T23:59:59.000Z

247

Evaluation of the 3M Organic Vapor Monitor #3500 as a sampling device for ethyl acrylate and the effect of discontinued exposure on vapor retention  

E-Print Network [OSTI]

Sampling Theories of Adsorption Forces of Adsorption Activation Procedures Surface Structure Statement of Hypotheses METHODOLOGV Test Atmosphere Generation Exposure Chamber MIRAN Calibration and Use Monitor Exposure to EA Analytical Procedures...EVALUATION OF THE 3M ORGANIC VAPOR MONITOR 53500 AS A SAMPLING DEVICE FOR ETHYL ACRYLATE AND THE EFFECT OF DISCONTINUED EXPOSURE ON VAPOP, RETENTION A Thesis by ROBERT WAYNE BARR Submitted to the Graduate College of Texas Al!M University...

Barr, Robert Wayne

2012-06-07T23:59:59.000Z

248

Evaluation of heterosis and heterosis retention in Bos taurus-Bos indicus crossbred cattle for reproductive and maternal traits in cows  

E-Print Network [OSTI]

EVALUATION OF HETEROSIS AND HETEROSIS RETENTION IN BOS TAURUS-BOS INDICUS CROSSBRED CATTLE FOR REPRODUCTIVE AND MATERNAL TRAITS IN COWS A Thesis by RODNEY OLIVER NEUFELD ARCE Submitted to the Office of Graduate Studies of Texas A&M... CATTLE FOR REPRODUCTIVE AND MATERNAL TRAITS IN COWS A Thesis by RODNEY OLIVER NEUFELD ARCE Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE...

Neufeld Arce, Rodney Oliver

2007-04-25T23:59:59.000Z

249

Managing high-bandwidth real-time data storage  

SciTech Connect (OSTI)

There exist certain systems which generate real-time data at high bandwidth, but do not necessarily require the long-term retention of that data in normal conditions. In some cases, the data may not actually be useful, and in others, there may be too much data to permanently retain in long-term storage whether it is useful or not. However, certain portions of the data may be identified as being vitally important from time to time, and must therefore be retained for further analysis or permanent storage without interrupting the ongoing collection of new data. We have developed a system, Mahanaxar, intended to address this problem. It provides quality of service guarantees for incoming real-time data streams and simultaneous access to already-recorded data on a best-effort basis utilizing any spare bandwidth. It has built in mechanisms for reliability and indexing, can scale upwards to meet increasing bandwidth requirements, and handles both small and large data elements equally well. We will show that a prototype version of this system provides better performance than a flat file (traditional filesystem) based version, particularly with regard to quality of service guarantees and hard real-time requirements.

Bigelow, David D. [Los Alamos National Laboratory; Brandt, Scott A [Los Alamos National Laboratory; Bent, John M [Los Alamos National Laboratory; Chen, Hsing-Bung [Los Alamos National Laboratory

2009-09-23T23:59:59.000Z

250

E-Print Network 3.0 - antiepileptic drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Ashwin Kumaria & Christos M. Tolias & Summary: have been shown to underlie seizures, and conventional antiepileptic drugs have been shown to attenuate... for antiepileptic drugs....

251

E-Print Network 3.0 - amplifies stent-based drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

IN STENT-BASED DRUG DELIVERY Giuseppe Pontrelli*, Filippo de Monte** *IAC... . Hwang, D. Wu, E.R. Edelman, Physiological transport forces govern drug...

252

E-Print Network 3.0 - antipsychotic drug ykp1358 Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Idle, J.R. (1997). Antipsychotic drug-induced movement disorders... Fleischhacker, W.W., Meise, U., Gunther, V., and Kurz, M. (1994). Compliance with antipsychotic drug...

253

E-Print Network 3.0 - active drug delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Clinic to introduce students to drug delivery, and in a senior-level elective... of the pharmaceutical industry today, with new drug ... Source: Hesketh, Robert - College of...

254

E-Print Network 3.0 - antimicrobial drug discovery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

skills in drug discovery, drug development, and clinical care to enter a career... in the pharmaceutical industry, in pharmaceutical development extending from ... Source: Abagyan,...

255

E-Print Network 3.0 - advanced drug design Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to this problem could be from rational drug design using Bioinformatics. The focus of the pharmaceutical industry... design. A successful and reliable drug design process could...

256

E-Print Network 3.0 - advanced drug delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

nano-biomaterials, pharmaceuticals and drug delivery. They are exploring numerous... the pharmaceutical industry--the PTRC has created a novel inhaled drug delivery method that...

257

E-Print Network 3.0 - antimalarial drug discovery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

REVIEWS | DRUG DISCOVERY VOLUME 3 | JUNE 2004 | 509 Summary: . Croft , Reto Brun|| and Solomon Nwaka Increased efforts in antimalarial drug discovery are urgently... for...

258

E-Print Network 3.0 - animal drugs change Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biology and Medicine ; Environmental Sciences and Ecology 3 RESOLUTION ON THE USE OF CHEMICALS AND DRUGS IN AQUACULTURE Summary: Investigational New Animal Drug (INAD) permits and...

259

E-Print Network 3.0 - anticancer drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sciences. his research interests include drug design and discovery, database mining of small- Summary: an internationally recognized program in drug design and discovery...

260

E-Print Network 3.0 - anticancer drug analysis Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

products, can have antibiotic, anticancer, anticholesterolemic... , and other activities that make them useful as drugs or drug leads for the treatment ... Source: New...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

E-Print Network 3.0 - anticancer drug development Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sciences. his research interests include drug design and discovery, database mining of small- Summary: an internationally recognized program in drug design and discovery...

262

E-Print Network 3.0 - artery disease drugs Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug Plan Benefit Guide Revised 101510 Summary: artery disease or congestive heart failure) are eligible for the Value-Based Prescription Drug Plan... (Coronary Artery...

263

E-Print Network 3.0 - antirheumatic drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

elderly: Pharmacy data as a tool for improvement Summary: Rochon PA, Gurwitz JH. Optimising drug treatment for elderly people: the prescribing cascade. BMJ 1997... for Drug...

264

E-Print Network 3.0 - antiparasital drug benznidazole Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

265

E-Print Network 3.0 - acute cutaneous drug Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Dundee Collection: Biology and Medicine 72 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: -inflammatory drugs are often...

266

E-Print Network 3.0 - alternative drug interaction Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mathematics 69 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

267

E-Print Network 3.0 - antithyroid drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Science 57 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

268

E-Print Network 3.0 - anti-rheumatic drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Science 91 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

269

E-Print Network 3.0 - anti-tuberculosis drugs induced Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

drugs induced Page: << < 1 2 3 4 5 > >> 1 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

270

E-Print Network 3.0 - assessing drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mathematics 28 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

271

E-Print Network 3.0 - arsenic-based antineoplastic drugs Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Health Care Settings" (http... Group 1 Carcinogens, Chemotherapy Waste and other Hazardous Drug...

272

E-Print Network 3.0 - antiparasitic drug nitazoxanide Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

273

E-Print Network 3.0 - antiinflammatory drug chemistry Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

drug chemistry Search Powered by Explorit Topic List Advanced Search Sample search results for: antiinflammatory drug chemistry Page: << < 1 2 3 4 5 > >> 1 Novel Anti-Inflammatory...

274

E-Print Network 3.0 - anticancer drug pump Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Therapeutic Delivery (2010) 1(2), 323334 Special FocuS: oncology Summary: drug efflux pumps, increasing drug metabolism, enhancing self-repairing ability or expressing altered......

275

Essays on prescription drug benefits in Medicare managed care  

E-Print Network [OSTI]

In this thesis, I estimate a structural demand model for prescription drug benefits by Medicare beneficiaries using data from the Medicare HMO program. I then use the utility parameter estimates to explore other questions ...

Hall, Anne Elizabeth, 1971-

2005-01-01T23:59:59.000Z

276

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

277

antiretroviral drug fosamprenavir: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(0.08 m... Brouwers, Joachim 2006-10-25 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

278

antidiabetic drugs present: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

data to perform a number of econometric studies to assess the health and economic impacts of new drug development and use. I hypothesize that people may obtain several kinds...

279

Needle-free drug delivery using shock wave techniques  

E-Print Network [OSTI]

A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

Pavlov, Atanas (Atanas Ivanov)

2006-01-01T23:59:59.000Z

280

A fully implantable intracochlear drug delivery device : development and characterization  

E-Print Network [OSTI]

In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

Swan, Erin Eileen Leary, 1976-

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Page 1 of 5 Alcohol and Other Drugs  

E-Print Network [OSTI]

Free Workplace Policy. 2.0 POLICY STATEMENT In compliance with the federal government's Drug Free, because of Mines' status as a federal contractor and grant recipient and because marijuana use is still

282

Mechanism Based Anticancer Drugs that Degrade Sp Transcription Factors  

E-Print Network [OSTI]

Curcumin is the active component of tumeric, and this polyphenolic compound has been extensively investigated as an anticancer drug that modulates multiple pathways and genes. We demonstrated that curcumin inhibited 253JB-V and KU7 bladder cancer...

Chadalapaka, Gayathri

2013-03-14T23:59:59.000Z

283

Biosynthetic engineering for the assembly of better drugs  

E-Print Network [OSTI]

The declining prospects of innovator pharmaceutical companies have been attributed to their inability to discover leads that bind to novel protein domains. All of the 21,000-odd drug products that have ever been approved ...

Yadav, Vikramaditya Ganapati

2013-01-01T23:59:59.000Z

284

Cellular responses against DNA damaged by platinum anticancer drugs  

E-Print Network [OSTI]

The anticancer activity of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is mediated by their ability to attack DNA such that generated adducts trigger numerous cellular responses. A better understanding ...

Jung, Yongwon, 1977-

2005-01-01T23:59:59.000Z

285

Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery  

E-Print Network [OSTI]

The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

Tan, Mei Chee

286

Microcapsule drug delivery device for treatment of glioblastoma multiforme  

E-Print Network [OSTI]

Controlled-release drug delivery systems are capable of treating debilitating diseases, including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. ...

Scott, Alexander Wesley

2010-01-01T23:59:59.000Z

287

Engineered microtissue platforms for modeling human pathophysiology and drug metabolism  

E-Print Network [OSTI]

Over 50% of all drug candidates entering clinical trials are abandoned due to insufficient efficacy or unexpected safety issues despite extensive pre-clinical testing. Liver metabolites that cause toxicity or other side ...

Li, Cheri Yingjie

2013-01-01T23:59:59.000Z

288

antiangiogenic drug assessed: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of 18 novel, anti-angiogenic 17- to 20-amino acid peptides Popel, Aleksander S. 10 Assessing malaria drug resistance in US military areas of operation using microarrays. Biology...

289

Carcinogenesis and Inflammatory Effects of Plutonium-Nitrate Retention in an Exposed Nuclear Worker and Beagle Dogs.  

SciTech Connect (OSTI)

The genetic and inflammatory response pathways elicited following plutonium exposure in archival lung tissue of an occupationally exposed human and experimentally exposed beagle dogs were investigated. These pathways include: tissue injury, apoptosis and gene expression modifications related to carcinogenesis and inflammation. In order to determine which pathways are involved, multiple lung samples from a plutonium exposed worker (Case 0269), a human control (Case 0385), and plutonium exposed beagle dogs were examined using histological staining and immunohistochemistry. Examinations were performed to identify target tissues at risk of radiation-induced fibrosis, inflammation, and carcinogenesis. Case 0269 showed interstitial fibrosis in peripheral and subpleural regions of the lung, but no pulmonary tumors. In contrast, the dogs with similar and higher doses showed pulmonary tumors primarily in brochiolo-alveolar, peripheral and subpleural alveolar regions. The TUNEL assay showed slight elevation of apoptosis in tracheal mucosa, tumor cells, and nuclear debris was present in the inflammatory regions of alveoli and lymph nodes of both the human and the dogs. The expression of apoptosis and a number of chemokine/cytokine genes was slightly but not significantly elevated in protein or gene levels compared to that of the control samples. In the beagles, mucous production was increased in the airway epithelial goblet cells and glands of trachea, and a number of chemokine/cytokine genes showed positive immunoreactivity. This analysis of archival tissue from an accidentally exposed worker and in a large animal model provides valuable information on the effects of long-term retention of plutonium in the respiratory tract and the histological evaluation study may impact mechanistic studies of radiation carcinogenesis.

Nielsen, Christopher E. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Wang, Xihai [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Robinson, Robert J. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Brooks, Antone L. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lovaglio, Jamie A. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Patton, Kristin M. [Battelle Toxicology Northwest, Richland, WA (United States); McComish, Stacey [United States Transuranium and Uranium Registries, Washington State University, College of Pharmacy, Richland, WA (United States); Tolmachev, Sergei Y. [United States Transuranium and Uranium Registries, Washington State University, College of Pharmacy, Richland, WA (United States); Morgan, William F. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

2014-01-01T23:59:59.000Z

290

Margin for In-Vessel Retention in the APR1400 - VESTA and SCDAP/RELAP5-3D Analyses  

SciTech Connect (OSTI)

If cooling is inadequate during a reactor accident, a significant amount of core material could become molten and relocate to the lower head of the reactor vessel, as happened in the Three Mile Island Unit 2 (TMI-2) accident. If it is possible to ensure that the lower head remains intact so that relocated core materials are retained within the vessel, the enhanced safety associated with such plants can reduce concerns about containment failure and associated risk. For example, the enhanced safety of the Westinghouse Advanced 600 MWe pressurized water reactor (PWR) (AP600), which relied upon external reactor vessel cooling (ERVC) for in-vessel retention (IVR), resulted in the U.S. Nuclear Regulatory Commission (USNRC) approving the design without requiring certain conventional features common to existing light water reactors (LWRs). IVR of core melt is therefore a key severe accident management strategy adopted by some operating nuclear power plants and proposed for some advanced LWRs. However, it is not clear that currently proposed ERVC without additional enhancements could provide sufficient heat removal for higher-power reactors (up to 1500 MWe). Hence, a three-year, United States (U.S.) -Korean International Nuclear Energy Research Initiative (INERI) project was initiated in which the Idaho National Engineering and Environmental Laboratory (INEEL), Seoul National University (SNU), Pennsylvania State University (PSU), and the Korean Atomic Energy Research Institute (KAERI) explored options, such as enhanced ERVC performance and an enhanced in-vessel core catcher (IVCC), that have the potential to ensure that IVR is feasible for higher power reactors.

Joy Rempe; D. Knudson

2004-12-01T23:59:59.000Z

291

Towards engineering hormone-binding globulins as drug delivery agents  

E-Print Network [OSTI]

directly for destruction by the bodys immune system. There are currently three antibody-drug conjugates and 11 naked monoclonal antibodies approved by the Food and Drug Administration for the treatment of cancers [9, 10]. Another form of immunotherapy... efficacy in many cases [50]. Currently, the most common chemotherapeutic treatment for malignant metastatic prostate cancer is docetaxel, a mitotic poison [51]. In the next part of this proof-of-concept experiment, we sought to show that it is possible...

Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

2014-11-26T23:59:59.000Z

292

Comparison of phenanthriplatin, a novel monofunctional platinum based anticancer drug candidate, with cisplatin, a classic bifunctional anticancer drug  

E-Print Network [OSTI]

Nucleotide excision repair, a DNA repair mechanism, is the major repair pathway responsible for removal of platinum-based anticancer drugs. In this study, 146 bp duplexes were prepared containing either a site-specific ...

Li, Meiyi, S.M. Massachusetts Institute of Technology

2012-01-01T23:59:59.000Z

293

Noncommutative Two Time Physics  

E-Print Network [OSTI]

We present a classical formalism describing two-time physics with Abelian canonical gauge field backgrounds. The formalism can be used as a starting point for the construction of an interacting quantized two-time physics theory in a noncommutative soace-time.

W. Chagas-Filho

2006-04-03T23:59:59.000Z

294

Asia Times -Search Asia  

E-Print Network [OSTI]

Asia Times - Search Asia Times Advanced Search Southeast Asia Scapegoats for Indonesia's timber://www.atimes.com/atimes/Southeast_Asia/EI19Ae01.html (1 of 4)9/4/2007 3:01:50 PM Search #12;Asia Times - rather than on the nationwide band

295

Asia Times -Search Asia  

E-Print Network [OSTI]

Asia Times - Search Asia Times Advanced Search Southeast Asia Scapegoats for Indonesia's timber://www.atimes.com/atimes/Southeast_Asia/EI19Ae01.html (1 of 4)9/4/2007 12:55:07 PM Search #12;Asia Times - rather than on the nationwide band

296

Separation of peptides from myoglobin enzymatic digests by RPLC. Influence of the mobile-phase composition and the pressure on the retention and separation  

SciTech Connect (OSTI)

The influence of the mobile-phase composition and the pressure on the chromatographic separation of the peptides from the enzymatic digest of myoglobin was studied under linear conditions. The retention behavior of these tryptic peptides was measured under isocratic conditions with different mobile-phase compositions, ranging from 9 to 28% (v/v) acetonitrile in 0.1% (v/v) aqueous trifluoroacetic acid. The effect of the pressure was studied by analyzing the separation of the tryptic peptides under different average column pressures between 14 and 220 bar, at 13, 20, and 26% (v/v) acetonitrile. The differences between the partial molar volumes of these peptides in the stationary and mobile phases were derived from these results. All the measurements were performed on a 10-cm-long C{sub 18}-bonded, end-capped monolithic column. The results obtained illustrate the highly complicated behavior of the complex peptide mixtures afforded by tryptic digestion. The capacity factors of the analyzed peptides do not depend linearly on the acetonitrile concentration but follow exactly a quadratic relationship. The adsorption changes of partial molar volumes are in good agreement with other literature data. The consequences of the influence of the average column pressure (hence of the flow rate) on the column phase ratio and on the retention factors of the peptides are discussed. The retention pattern of the complex mixture is affected by both the mobile-phase composition and the pressure, and the resolution of certain peptide pairs is so much affected by the pressure that inversions in the elution order of some pairs are observed.

Marchetti, Nicola [University of Tennessee, Knoxville (UTK); Guiochon, Georges A [ORNL

2005-06-01T23:59:59.000Z

297

Drug-Free Workplace Program UT-B Contracts Page 1 of 1  

E-Print Network [OSTI]

Drug-Free Workplace Program UT-B Contracts Sep 2012 Page 1 of 1 drug-free-workplace-ext-sep12 DRUG-FREE, the Seller and its subcontractors working on the project site must maintain a drug-free workplace program. (B) If the Seller is an out-of-state entity, the Company may upon request allow a drug-free workplace

Pennycook, Steve

298

The use of carbon stable isotope ratios in drugs characterization  

SciTech Connect (OSTI)

Isotopic Ratio Mass Spectrometry (IRMS) is an effective toll to be used for drug product authentication. The isotopic composition could be used to assist in the differentiation between batches of drugs and assist in the identification of counterfeit materials on the market. Only two factors affect the isotopic ratios in pharmaceutical components: the isotopic composition of the raw materials and the synthetic processes performed upon them. Counterfeiting of pharmaceutical drugs threatens consumer confidence in drug products companies' economical well-being. In this preliminary study, the analyzed samples consist in two types of commercially available analgesics, which were purchases from Romanian pharmacies. Differences in ?{sup 13}C between batches from ?29.7 to ?31.6% were observed, demonstrating that this method can be used to differentiate among individual drug batches and subsequently identify counterfeits on the market. On the other hand, carbon isotopic ratios differences among producers were recorded, the variations being between ?31.3 to ?34.9% for the same type of analgesic, but from different manufactures.

Magdas, D. A., E-mail: gabriela.cristea@itim-cj.ro; Cristea, G., E-mail: gabriela.cristea@itim-cj.ro; Bot, A., E-mail: gabriela.cristea@itim-cj.ro; Mirel, V., E-mail: gabriela.cristea@itim-cj.ro [National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Str., 400293 Cluj-Napoca (Romania)

2013-11-13T23:59:59.000Z

299

Matter: Space without Time  

E-Print Network [OSTI]

While Quantum Gravity remains elusive and Quantum Field Theory retains the interpretational difficulties of Quantum Mechanics, we have introduced an alternate approach to the unification of particles, fields, space and time, suggesting that the concept of matter as space without time provides a framework which unifies matter with spacetime and in which we anticipate the development of complete theories (ideally a single unified theory) describing observed 'particles, charges, fields and forces' solely with the geometry of our matter-space-time universe.

Yousef Ghazi-Tabatabai

2012-11-19T23:59:59.000Z

300

Intrinsic Time Quantum Geometrodynamics  

E-Print Network [OSTI]

Quantum Geometrodynamics with intrinsic time development and momentric variables is presented. An underlying SU(3) group structure at each spatial point regulates the theory. The intrinsic time behavior of the theory is analyzed, together with its ground state and primordial quantum fluctuations. Cotton-York potential dominates at early times when the universe was small; the ground state naturally resolves Penrose's Weyl Curvature Hypothesis, and thermodynamic and gravitational `arrows of time' point in the same direction. Ricci scalar potential corresponding to Einstein's General Relativity emerges as a zero-point energy contribution. A new set of fundamental commutation relations without Planck's constant emerges from the unification of Gravitation and Quantum Mechanics.

Eyo Eyo Ita III; Chopin Soo; Hoi-Lai Yu

2015-02-06T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Intrinsic Time Quantum Geometrodynamics  

E-Print Network [OSTI]

Quantum Geometrodynamics with intrinsic time development and momentric variables is presented. An underlying SU(3) group structure at each spatial point regulates the theory. The intrinsic time behavior of the theory is analyzed, together with its ground state and primordial quantum fluctuations. Cotton-York potential dominates at early times when the universe was small; the ground state naturally resolves Penrose's Weyl Curvature Hypothesis, and thermodynamic and gravitational `arrows of time' point in the same direction. Ricci scalar potential corresponding to Einstein's General Relativity emerges as a zero-point energy contribution. A new set of fundamental canonical commutation relations without Planck's constant emerges from the unification of Gravitation and Quantum Mechanics.

Eyo Eyo Ita III; Chopin Soo; Hoi-Lai Yu

2015-01-26T23:59:59.000Z

302

On the Time Times Temperature Bound  

E-Print Network [OSTI]

Recently Hod proposes a lower bound on the relaxation time of a perturbed thermodynamic system. For gravitational systems this bound transforms into a condition on the fundamental quasinormal frequency. We test the bound in some spacetimes whose quasinormal frequencies are calculated exactly, as the three-dimensional BTZ black hole, the D-dimensional de Sitter spacetime, and the D-dimensional Nariai spacetime. We find that for some of these spacetimes their fundamental quasinormal frequencies do not satisfy the bound proposed by Hod.

A. Lopez-Ortega

2010-06-28T23:59:59.000Z

303

Scaling Laws for Reduced-Scale Tests of Pulse Jet Mixing Systems in Non-Newtonian Slurries: Gas Retention and Release Behavior  

SciTech Connect (OSTI)

The Waste Treatment Plant (WTP) under construction at the Hanford Site will use pulse jet mixer (PJM) technology for mixing and gas retention control applications in tanks expected to contain waste slurries exhibiting a non-Newtonian rheology. This paper presents the results of theoretical and experimental studies performed to establish the methodology to perform reduced-scale gas retention and release tests with PJM systems in non-Newtonian fluids with gas generation. The technical basis for scaled testing with unsteady jet mixing systems in gas-generating non-Newtonian fluids is presented in the form of a bubble migration model that accounts for the gas generation rate, the average bubble rise velocity, and the geometry of the vessel. Scaling laws developed from the model were validated with gas holdup and release tests conducted at three scales: large scale, 1/4 scale, and 1/9 scale. Experiments were conducted with two non-Newtonian simulants with in-situ gas generation by decomposition of hydrogen peroxide. The data were compared non-dimensionally, and the important scale laws were examined. From these results, scaling laws are developed which allow the design of mixing systems at a reduced scale.

Stewart, Charles W.; Meyer, Perry A.; Kurath, Dean E.; Barnes, Steven M.

2006-03-02T23:59:59.000Z

304

Time functions as utilities  

E-Print Network [OSTI]

Every time function on spacetime gives a (continuous) total preordering of the spacetime events which respects the notion of causal precedence. The problem of the existence of a (semi-)time function on spacetime and the problem of recovering the causal structure starting from the set of time functions are studied. It is pointed out that these problems have an analog in the field of microeconomics known as utility theory. In a chronological spacetime the semi-time functions correspond to the utilities for the chronological relation, while in a K-causal (stably causal) spacetime the time functions correspond to the utilities for the K^+ relation (Seifert's relation). By exploiting this analogy, we are able to import some mathematical results, most notably Peleg's and Levin's theorems, to the spacetime framework. As a consequence, we prove that a K-causal (i.e. stably causal) spacetime admits a time function and that the time or temporal functions can be used to recover the K^+ (or Seifert) relation which indeed turns out to be the intersection of the time or temporal orderings. This result tells us in which circumstances it is possible to recover the chronological or causal relation starting from the set of time or temporal functions allowed by the spacetime. Moreover, it is proved that a chronological spacetime in which the closure of the causal relation is transitive (for instance a reflective spacetime) admits a semi-time function. Along the way a new proof avoiding smoothing techniques is given that the existence of a time function implies stable causality, and a new short proof of the equivalence between K-causality and stable causality is given which takes advantage of Levin's theorem and smoothing techniques.

E. Minguzzi

2009-09-04T23:59:59.000Z

305

Fundamental chromatographic equations designed for columns packed with very fine particles and operated at very high pressures applications to the prediction of elution times and the column efficiencies  

SciTech Connect (OSTI)

The wall temperatures of three Acquity-BEH-C{sub 18}columns (2.1 mm x 50, 100, and 150 mm) and the temperature of the incoming eluent were maintained constant at 289 K, using a circulating water heat exchanger. The retention times and the band broadening of naphtho[2,3-a]pyrene were measured for each column as a function of the flow rate applied. Pure acetonitrile was used as the eluent. The flow rate dependence of neither elution volumes nor bandwidths can be accounted for by classical models of retention and HETP, respectively, since these models assume columns to be isothermal. Because the heat generated by friction of the eluent against the column bed increases with increasing flow rate, the column bed cannot remain isothermal at high flow rates. This heat is evacuated radially and/or longitudinally by convection, conduction, and radiation. Radial and axial temperature gradients are formed, which are maximum and minimum, respectively, when the temperature of the column wall is kept uniform and constant. The retention times that we measured match well with the values predicted based on the temperature distribution along and across the column, which we calculated and on the temperature dependence of the retention for the same column operated isothermally (i.e., at very low flow rate). The rate of band spreading varies along non-isothermal columns, so the HETP can only be defined locally. It is a function of the axial coordinate. A new contribution is needed to account for the radial thermal heterogeneity of the column, hence the radial distribution of the flow velocities, which warps the elution band. A new model, based on the general dispersion theory of Aris, allows a successful prediction of the unusually large bandwidths observed with columns packed with fine particles, operated at high flow rates, hence high inlet pressures.

Gritti, Fabrice [University of Tennessee, Knoxville (UTK); Guiochon, Georges A [ORNL

2008-01-01T23:59:59.000Z

306

Physicochemical investigations of a drug delivery oscillator  

E-Print Network [OSTI]

75 mM Glucose/10 % MAA /kmarble= 0.00199 s-1 I = 50 mM (50 mM NaCl+0 mM CaCl2) I = 95 mM (50 mM NaCl + 15 mM CaCl2) I = 155 mM (50 mM NaCl+ 35 mM CaCl2) I = 155 mM (155 mM NaCl+ 0 mM CaCl2) p H Device Membrane - Hydrogel N...4.6 4.7 4.8 4.9 5 5.1 5.2 5.3 5.4 0 0.2 0.4 0.6 0.8 1 Time (Days) p H Glucose Gluconic acid Gluconic acid Gluconate- + H+ H+ + CaCO3 Ca 2+ + HCO3- H+ + HCO3- H2CO3 pKa = 6.37 H2CO3 CO2 ? + H2O pKa = 3.6 ? Buffer Build-Up Affects...

Bhalla, A. S.; Siegel, R. A.

2006-10-27T23:59:59.000Z

307

Is Time Inhomogeneous ?  

E-Print Network [OSTI]

In this article, we discuss probability of inhomogeneous time in high or low energy scale of physics. Consequently, the possibility was investigated of using theories such as varying speed of light (VSL) and fractal mathematics to build a framework within which answers can be found to some of standard cosmological problems and physics theories on the basis of time non-homogeneity.

S. Davood Sadatian

2014-05-08T23:59:59.000Z

308

Probabilistic time-series  

E-Print Network [OSTI]

SCIA 2003 Tutorial: Hidden Markov Models Sam Roweis, University of Toronto June 29, 2003 Probabilistic Generative Models for Time Series #15; Stochastic models for time-series: y 1 ; y 2 ; : : : ; y #15; Add noise to make the system stochastic: p(y t jy t 1 ;y t 2 ; : : : ;y t k ) #15; Markov models

Roweis, Sam

309

TIMELY WARNING CAMPUS ALERT  

E-Print Network [OSTI]

TIMELY WARNING CAMPUS ALERT 13 September 2007 This communication is prepared as part of the Timely of 1990. This federal law requires a general communication to the campus community of all crimes reported. Consider carefully whether your presence at or near the Lancaster Green Apartments while unaccompanied

Hardy, Christopher R.

310

Kelly Scientific Resources Kelly Scientific Resources yy BIOTECHNOLOGY DRUG &  

E-Print Network [OSTI]

Kelly Scientific Resources Kelly Scientific Resources yy BIOTECHNOLOGY DRUG & PHARMACEUTICAL · What Kelly Scientific Resources or staffing agencies are and how they work?they work? · How to work Role: ­ Northern California Recruiting and Business efforts for Kelly Scientific Resources ­ Promote

Puglisi, Joseph

311

Optimization and Simulation in Drug Development -Review and Analysis  

E-Print Network [OSTI]

in the context of the pharmaceutical industry. 4 #12; 1 Introduction The presen-Eriksen and Jens Clausen Keywords: Pharmaceutical R&D, Drug Discovery and Development, Modelling and sim- ulation, Clinical Trial Simulation Portfolio optimization 1 #12; Contents 1 Introduction 5 2 Pharmaceutical products

312

Protein Dynamics in Drug Combinations: a Linear Superposition  

E-Print Network [OSTI]

on cells and organisms. Little is known about how drugs affect protein dynamics that deter- mine or activity) of one of the cells proteins (Figure 1). The goal is to guide the cell from a ``sick state'' to a ``healthy state'' in a rational manner (or, in the case of cancer, from a living cancer cell to a dead

313

Molecular Fragment Mining for Drug Discovery Christian Borgelt1  

E-Print Network [OSTI]

Molecular Fragment Mining for Drug Discovery Christian Borgelt1 , Michael R. Berthold2 , and David will be active or inactive, so that future chemical tests can be focused on the most promis- ing candidates that discriminate between active and inactive molecules. In this paper we review this approach as well as two

Berthold, Michael R.

314

Drug Delivery DOI: 10.1002/anie.200802260  

E-Print Network [OSTI]

of a model compound, luciferin, from poly(lactic acid) (PLA) particles (approximately 250­350 nm in size nanoparticle could be engineered to target different cells.[3,6] PLA is an Food and Drug Administration (FDA with supercritical carbon dioxide (sc-CO2). PLA can also serve as a representative material for our process which can

Zare, Richard N.

315

Nearly all current drugs for osteoporosis act by inhibiting the  

E-Print Network [OSTI]

for the development of osteoporosis in post-menopausal women. Control mice developed an osteopaenia, whereas mice fedNearly all current drugs for osteoporosis act by inhibiting the resorption of bone, and novel or reverse this disease in rodents. Osteoporosis is characterized by decreased bone density and strength

316

Smart drug discovery leveraging innovative technologies and predictive knowledge  

E-Print Network [OSTI]

the risk of failure. Owing to the integration of key in silico and experimental tools. A positive aspect of this paradigm shift includes faster,strategic decision making with respect to drug targets from the human genome pro- vides opportunities for detailed analysis of structure and function

Cai, Long

317

(c) Meade & Roach, LLP 1 Medicare's Impact on Cardiology Drugs  

E-Print Network [OSTI]

(c) Meade & Roach, LLP 1 Medicare's Impact on Cardiology Drugs and Devices During Clinical Research Ryan Meade, JD Meade & Roach, LLP July 15, 2008 Baltimore, Maryland University of Maryland School of Medicine #12;(c) Meade & Roach, LLP 2 Overview Theme: Understanding Medicare reimbursement helps

Weber, David J.

318

New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis  

E-Print Network [OSTI]

We report results of an experimental study, complemented by detailed statistical analysis of the experimental data, on the development of a more effective control method of drug delivery using a pH sensitive acrylic polymer. New copolymers based on acrylic acid and fatty acid are constructed from dodecyl castor oil and a tercopolymer based on methyl methacrylate, acrylic acid and acryl amide were prepared using this new approach. Water swelling characteristics of fatty acid, acrylic acid copolymer and tercopolymer respectively in acid and alkali solutions have been studied by a step-change method. The antibiotic drug cephalosporin and paracetamol have also been incorporated into the polymer blend through dissolution with the release of the antibiotic drug being evaluated in bacterial stain media and buffer solution. Our results show that the rate of release of paracetamol getss affected by the pH factor and also by the nature of polymer blend. Our experimental data have later been statistically analyzed to quantify the precise nature of polymer decay rates on the pH density of the relevant polymer solvents. The time evolution of the polymer decay rates indicate a marked transition from a linear to a strictly non-linear regime depending on the whether the chosen sample is a general copolymer (linear) or a tercopolymer (non-linear). Non-linear data extrapolation techniques have been used to make probabilistic predictions about the variation in weight percentages of retained polymers at all future times, thereby quantifying the degree of efficacy of the new method of drug delivery.

N. Panja; A. K. Chattopadhyay

2014-12-05T23:59:59.000Z

319

Environment Induced Time Arrow  

E-Print Network [OSTI]

The spread of the time arrows from the environment to an observed subsystem is followed within a harmonic model. A similarity is pointed out between irreversibility and a phase with spontaneously broken symmetry. The causal structure of interaction might be lost in the irreversible case, as well. The Closed Time Path formalism is developed for classical systems and shown to handle the time arrow problem in a clear and flexible manner. The quantum case is considered, as well, and the common origin of irreversibility and decoherence is pointed out.

Janos Polonyi

2012-06-25T23:59:59.000Z

320

REVIEWS Drug Discovery Today Volume 12, Numbers 1/2 January 2007 Drug-target identification in Drosophila  

E-Print Network [OSTI]

the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery studies over the years has relied on the ease of growing this organism and the powerful genetic tools such as the insulin, epidermal growth factor, transforming growth factor b, Wnt, Hedgehog, JAK/STAT and Notch pathways

Perrimon, Norbert

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Time, energy & form  

E-Print Network [OSTI]

Physical manifestations of time occur in natural forms of all sizes. Architectural form serves as shelter while providing a built envelope of human life, simultaneously influencing and influenced by energetic activities ...

McInnis, Martha Jane

1982-01-01T23:59:59.000Z

322

Detecting drug-induced prolongation of the QRS complex: New insights for cardiac safety assessment  

SciTech Connect (OSTI)

Background: Drugs slowing the conduction of the cardiac action potential and prolonging QRS complex duration by blocking the sodium current (I{sub Na}) may carry pro-arrhythmic risks. Due to the frequency-dependent block of I{sub Na}, this study assesses whether activity-related spontaneous increases in heart rate (HR) occurring during standard dog telemetry studies can be used to optimise the detection of class I antiarrhythmic-induced QRS prolongation. Methods: Telemetered dogs were orally dosed with quinidine (class Ia), mexiletine (class Ib) or flecainide (class Ic). QRS duration was determined standardly (5 beats averaged at rest) but also prior to and at the plateau of each acute increase in HR (3 beats averaged at steady state), and averaged over 1 h period from 1 h pre-dose to 5 h post-dose. Results: Compared to time-matched vehicle, at rest, only quinidine and flecainide induced increases in QRS duration (E{sub max} 13% and 20% respectively, P < 0.010.001) whereas mexiletine had no effect. Importantly, the increase in QRS duration was enhanced at peak HR with an additional effect of + 0.7 0.5 ms (quinidine, NS), + 1.8 0.8 ms (mexiletine, P < 0.05) and + 2.8 0.8 ms (flecainide, P < 0.01) (calculated as QRS at basal HR-QRS at high HR). Conclusion: Electrocardiogram recordings during elevated HR, not considered during routine analysis optimised for detecting QT prolongation, can be used to sensitise the detection of QRS prolongation. This could prove useful when borderline QRS effects are detected. Analysing during acute increases in HR could also be useful for detecting drug-induced effects on other aspects of cardiac function. -- Highlights: ? We aimed to improve detection of drug-induced QRS prolongation in safety screening. ? We used telemetered dogs to test class I antiarrhythmics at low and high heart rate. ? At low heart rate only quinidine and flecainide induced an increase in QRS duration. ? At high heart rate the effects of two out of three antiarrhythmics were enhanced. ? Detection of a drug-induced prolongation of QRS was improved at high heart rate.

Cros, C., E-mail: caroline.cros@hotmail.co.uk [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Skinner, M., E-mail: Matthew.Skinner@astrazeneca.com [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Moors, J. [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom)] [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Lainee, P. [Sanofi-Aventis R and D, 371, rue du Pr Joseph Blayac, 34184 Montpellier Cedex 04 (France)] [Sanofi-Aventis R and D, 371, rue du Pr Joseph Blayac, 34184 Montpellier Cedex 04 (France); Valentin, J.P. [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom)] [Safety Pharmacology, Global Safety Assessment, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Macclesfield, SK10 4TG (United Kingdom)

2012-12-01T23:59:59.000Z

323

Results of 1999 Spectral Gamma-Ray and Neutron Moisture Monitoring of Boreholes at Specific Retention Facilities in the 200 East Area, Hanford Site  

SciTech Connect (OSTI)

Twenty-eight wells and boreholes in the 200 East Are% Hanford Site, Washington were monitored in 1999. The monitored facilities were past-practice liquid waste disposal facilities and consisted of six cribs and nineteen ''specific retention'' cribs and trenches. Monitoring consisted of spectral gamma-ray and neutron moisture logging. All data are included in Appendix B. The isotopes {sup 137}Cs, {sup 60}Co, {sup 235}U, {sup 238}U, and {sup 154}Eu were identified on spectral gamma logs from boreholes monitoring the PUREX specific retention facilities; the isotopes {sup 137}Cs, {sup 60}Co, {sup 125}Sb, and {sup 154}Eu were identified on the logs from boreholes at the BC Controlled Area cribs and trenches; and {sup 137}Cs, {sup 60}Co, and {sup 125}Sb were, identified on the logs from boreholes at the BX specific retention trenches. Three boreholes in the BC Controlled Area and one at the BX trenches had previous spectral gamma logs available for comparison with 1999 logs. Two of those logs showed that changes in the subsurface distribution of {sup 137}CS and/or {sup 60}Co had occurred since 1992. Although the changes are not great, they do point to continued movement of contaminants in the vadose zone. The logs obtained in 1999 create a larger baseline for comparison with future logs. Numerous historical gross gamma logs exist from most of the boreholes logged. Qualitative comparison of those logs with the 1999 logs show many substantial changes, most of which reflect the decay of deeper short-lived isotopes, such as {sup 106}Ru and {sup 125}Sb, and the much slower decay of shallower and longer-lived isotopes such as {sup 137}Cs. The radionuclides {sup 137}Cs and {sup 60}Co have moved in two boreholes since 1992. Given the amount of movement and the half-lives of the isotopes, it is expected that they will decay to insignificant amounts before reaching groundwater. However, gamma ray logging cannot detect many of the contaminants of interest such as {sup 99}Tc, NO{sub 3}, or {sup 129}I, all of which can be highly mobile in the vadose zone and, for the radionuclides, have long half-lives.

DG Horton; RR Randall

2000-01-18T23:59:59.000Z

324

Assessing the impact of tumor evolution on oncology drug development and commercialization  

E-Print Network [OSTI]

This thesis investigates the commercial viability of developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs ...

Sterk, Joseph P. (Sterk, Joseph Phillip)

2011-01-01T23:59:59.000Z

325

E-Print Network 3.0 - anticancer drugs infusion Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

drugs infusion Search Powered by Explorit Topic List Advanced Search Sample search results for: anticancer drugs infusion Page: << < 1 2 3 4 5 > >> 1 Friday, April 29, 2011 UNM...

326

Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport  

E-Print Network [OSTI]

Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

Tang, Hua, 1972-

2002-01-01T23:59:59.000Z

327

Medical data mining : improving information accessibility using online patient drug reviews  

E-Print Network [OSTI]

We address the problem of information accessibility for patients concerned about, pharmaceutical drug side effects and experiences. We create a new corpus of online patient-provided drug reviews and present our initial ...

Li, Yueyang Alice

2011-01-01T23:59:59.000Z

328

Changes in the characteristics of approved New Drug Applications for antihypertensives  

E-Print Network [OSTI]

In this thesis, the control of hypertension provides the backdrop for my effort to investigate how clinical trial design has evolved for antihypertensive drug submissions reviewed and approved by the Food and Drug ...

MacNeil, John Simon Howe

2007-01-01T23:59:59.000Z

329

Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON  

E-Print Network [OSTI]

Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON Dec. 20, 2012-- The Imagery of pornography: like war porn, torture porn or the standard naked-people porn, drug porn offers up a taste

Fernandez, Eduardo

330

Synthesis and Characterization of a Magnetically Responsive Polymeric Drug Delivery System  

E-Print Network [OSTI]

A magnetic target drug delivery system consisting of biodegradable polymeric microspheres (poly D, L-lactic acid) loaded with magnetite nanoparticles (10-100 nm) and anticancer drug (paclitaxel) was studied. The magnetite ...

Yu, Shi

331

The dual-piston jet injector and the viability of drug delivery  

E-Print Network [OSTI]

Drug delivery through jet-injection opens the doors to very rapid drug dispersion by eliminating the need for needle sterilization. With this comes the need for a continuous flow of fluids from a large reservoir, currently ...

Cunningham, Daniel (Daniel P.)

2007-01-01T23:59:59.000Z

332

E-Print Network 3.0 - activation inhibits drug-resistant Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

as a function of: (i) the transmissibility (i.e., fitness) of the drug-resistant... that transmission of drug-resistant strains in Botswana could increase to ,15% by 2009 if...

333

E-Print Network 3.0 - anti-cancer drug design Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: anti-cancer drug design Page: << < 1 2 3 4 5 > >> 1 Biology-based Drug Design Summary: - New...

334

FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data Taken at ALS FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data...

335

Computational analysis of biochemical networks for drug target identification and therapeutic intervention design  

E-Print Network [OSTI]

Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear ...

Paudel, Nirmala

2014-01-01T23:59:59.000Z

336

ESPC Success Story- Food and Drug Administration (FDA) White Oak Campus  

Broader source: Energy.gov [DOE]

FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus.

337

E-Print Network 3.0 - antimalarial drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease pathophysiology, drug resistance... and antimalarial resistance, and optimising treatments for pregnant women melioidosis - conducting clinical... treatments,...

338

E-Print Network 3.0 - antiretroviral drug costs Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: pediatric antiretroviral drug formulations, lack of personnel with health care expertise in treatment... formulations and simplified ARV regimens optimized...

339

CABM Symposium Applications of NMR to structure-based drug design in structural  

E-Print Network [OSTI]

CABM Symposium Applications of NMR to structure-based drug design in structural genomics Robert, structure-based drug design, structural genomics Abstract Structural genomics is poised to have a tremendous design in the era of structural genomics. Introduction Structure-based drug design has established itself

Powers, Robert

340

Changes in the nuclear uptake and retention of /sup 3/H-estrogen in gonadotrophs and lactotrophs as a function of age  

SciTech Connect (OSTI)

A quantitative autoradiographic immunocytochemical study was performed in which the nuclear uptake and retention of /sup 3/H-estradiol (/sup 3/H-E2) by luteinizing hormone (LH) and prolactin (PRL) cells was examined in 19-21-year-old baboons. /sup 3/H-E2 concentrating cells were found in all of the three lobes of the pituitary in varying percentages. Approximately 80% of PRL cells and nearly 100% of LH cells were labeled. A count of the number of silver grains over nuclei revealed a marked variation of the accumulation of /sup 3/H-E2 by LH cells and to a lesser extent in PRL cells. These results suggest functional heterogeneity among LH and PRL cells. The present results are discussed in relation to the physiological state of old animals.

Nogami, H.; Yoshimura, F.; Herbert, D.C.; Aufdemorte, T.B.; Gates, G.A.; Holt, G.R.; Sheridan, P.J.

1985-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Overview of the US-Japan collaborative investigation on hydrogen isotope retention in neutron-irradiated and ion-damaged tungsten  

SciTech Connect (OSTI)

Plasma-facing components (PFCs) will be exposed to 14 MeV neutrons from deuterium-tritium (D-T) fusion reactions, and tungsten, a candidate PFC for the divertor in ITER, is expected to receive a neutron dose of 0.7 displacement per atom (dpa) by the end of operation in ITER. The effect of neutron-irradiation damage has been mainly simulated using high-energy ion bombardment. While this prior database of results is quite valuable for understanding the behavior of hydrogen isotopes in PFCs, it does not encompass the full range of effects that must be considered in a practical fusion environment due to short penetration depth, damage gradient, high damage rate, and high PKA energy spectrum of the ion bombardment. In addition, neutrons change the elemental composition via transmutations, and create a high radiation environment inside PFCs, which influence the behavior of hydrogen isotope in PFCs, suggesting the utilization of fission reactors is necessary for neutron irradiation. Therefore, the effort to correlate among high-energy ions, fission neutrons, and fusion neutrons is crucial for accurately estimating tritium retention under a neutron-irradiation environment. Under the framework of the US-Japan TITAN program, tungsten samples (99.99 at. % purity from A.L.M.T. Co.) were irradiated by neutron in the High Flux Isotope Reactor (HFIR), ORNL, at 50 and 300C to 0.025, 0.3, and 1.2 dpa, and the investigation of deuterium retention in neutron-irradiation was performed in the INL Tritium Plasma Experiment (TPE), the unique high-flux linear plasma facility that can handle tritium, beryllium and activated materials. This paper reports the recent results from the comparison of ion-damaged tungsten via various ion species (2.8 MeV Fe2+, 20 MeV W2+, and 700 keV H-) with that from neutron-irradiated tungsten to identify the similarities and differences among them.

Masashi Shimada; Y. Hatano; Y. Oya; T. Oda; M. Hara; G. Cao; M. Kobayashi; M. Sokolov; H. Watanabe; B. Tyburska; Y. Ueda; P. Calderoni

2011-09-01T23:59:59.000Z

342

Decoherence and time emergence  

E-Print Network [OSTI]

In this work the possible role that Decoherence Model could play in the emergence of the classical concept of time is analyzed. We take the case of a Mixmaster universe with small anisotropy and construct its Halliwell propagator. Afterwards we introduce in our system terms that comprise the effects of Decoherence Model. This is done by means of the so called Restricted Path Integral Formalism. We obtain Halliwell's modified propagator and find that a gauge invariant physical time emerges as consequence of this process.

A. Camacho

1998-07-30T23:59:59.000Z

343

Use of Preventative and Therapeutic Drugs in Show Market Animals  

E-Print Network [OSTI]

Various preventive and therapeutic medicines may be used for disease management in show mar- ket livestock and poultry. These include vaccines and bacterins, antibiotics and antibacterials, para- siticides and corticosteroids. Exhibitors of show ani.... These instructions are to be followed precisely. L-2335 2-01 Use of Preventive and Therapeutic Drugs in Show Market Animals F.C. Faries, Jr. Associate Professor and Extension Program Leader for Veterinary Medicine The Texas A&M University System Testing The Food...

Faries Jr., Floron C.

2001-03-12T23:59:59.000Z

344

The fibrate drug gemfibrozil disrupts lipoprotein metabolism in rainbow trout  

SciTech Connect (OSTI)

Gemfibrozil (GEM) is a fibrate drug consistently found in effluents from sewage treatment plants. This study characterizes the pharmacological effects of GEM on the plasma lipoproteins of rainbow trout (Oncorhynchus mykiss). Our goals were to quantify the impact of the drug on: 1) lipid constituents of lipoproteins (phospholipids (PL), triacylglycerol (TAG), and cholesterol), 2) lipoprotein classes (high, low and very low density lipoproteins), and 3) fatty acid composition of lipoproteins. Potential mechanisms of GEM action were investigated by measuring lipoprotein lipase activity (LPL) and the hepatic gene expression of LPL and of the peroxisome proliferator-activated receptor (PPAR) {alpha}, {beta}, and {gamma} isoforms. GEM treatment resulted in decreased plasma lipoprotein levels (- 29%) and a reduced size of all lipoprotein classes (lower PL:TAG ratios). However, the increase in HDL-cholesterol elicited by GEM in humans failed to be observed in trout. Therefore, HDL-cholesterol cannot be used to assess the impact of the drug on fish. GEM also modified lipoprotein composition by reducing the abundance of long-chain n-3 fatty acids, thereby potentially reducing the nutritional quality of exposed fish. The relative gene expression of LPL was increased, but the activity of the enzyme was not, and we found no evidence for the activation of PPAR pathways. The depressing effects of GEM on fish lipoproteins demonstrated here may be a concern in view of the widespread presence of fibrates in aquatic environments. Work is needed to test whether exposure to environmental concentrations of these drugs jeopardizes the capacity of fish for reproduction, temperature acclimation or migratory behaviors.

Prindiville, John S., E-mail: jprin041@uottawa.ca; Mennigen, Jan A.; Zamora, Jake M.; Moon, Thomas W.; Weber, Jean-Michel

2011-03-15T23:59:59.000Z

345

Drug repositioning and indication discovery using description logics  

E-Print Network [OSTI]

behind the repurposing. Understanding the logic backing the 21 findings is paramount in order to build successful predictive methods later on. 1.2.1 Sildenafil: repositioning from clinical side-effects The National Health Service (NHS) defines angina as a... breast cancer preventive properties. This drug is an example of smart and continuous development, expanding from one indication to another. The fundamental reasons behind the repositioning are grounded on early-stage experimental evidence and not due to a...

Croset, Samuel

2014-10-07T23:59:59.000Z

346

Feeling molecular forces: tactile feedback to enhance drug design  

E-Print Network [OSTI]

Programs 8 Academic Scholarships Texas A8 M University In partial fulfillment of the requirements of the UNIVERSITY UNDERGRADUATE RESEARCH FELLOWS Approved as to style and content by: Edgar F. Meyer' (Fellows-Co-Advisor) Edward A. Funkhouser... (Executive Director) Stanley . Swanson (Fellows o-Advisor) April 2000 Group: Computer Science ABSTRACT FEELING MOLECULAR FORCES: TACTII E FEEDBACK TO ENHANCE DRUG DESIGN. (April 2000) Jocylin Amber Williams Department of Biochemistry and Biophysics...

Williams, Jocylin Amber

2013-02-22T23:59:59.000Z

347

Time reversal communication system  

DOE Patents [OSTI]

A system of transmitting a signal through a channel medium comprises digitizing the signal, time-reversing the digitized signal, and transmitting the signal through the channel medium. The channel medium may be air, earth, water, tissue, metal, and/or non-metal.

Candy, James V. (Danville, CA); Meyer, Alan W. (Danville, CA)

2008-12-02T23:59:59.000Z

348

Time and Attendance Reporting  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

DOE O 535.1 establishes the Department's requirements and responsibilities governing time and attendance reporting. The purpose of this revision is to reflect the transition of payroll processing from the Capital Accounting Center to the Defense Finance and Accounting System. Cancels DOE O 3600.1B. Canceled by DOE O 322.1C.

2004-10-22T23:59:59.000Z

349

Fuzzy Space-Time  

E-Print Network [OSTI]

A review is made of recent efforts to define linear connections and their corresponding curvature within the context of noncommutative geometry. As an application it is suggested that it is possible to identify the gravitational field as a phenomenological manifestation of space-time commutation relations and to thereby clarify its role as an ultraviolet regularizer.

J. Madore

1996-07-26T23:59:59.000Z

350

Time-Encoded Imagers.  

SciTech Connect (OSTI)

This report provides a short overview of the DNN R&D funded project, Time-Encoded Imagers. The project began in FY11 and concluded in FY14. The Project Description below provides the overall motivation and objectives for the project as well as a summary of programmatic direction. It is followed by a short description of each task and the resulting deliverables.

Marleau, Peter; Brubaker, Erik

2014-11-01T23:59:59.000Z

351

STOPPING TIMES IN QUANTUM MECHANICS  

E-Print Network [OSTI]

(Stinespring, Kraus). 3". Time-dependant case General time evolution of an open quantum sys- tem = (Pt)t0

Attal, Stéphane

352

Rick Grush Brain time and phenomenological time (draft) Page 1/37 Brain time and phenomenological time  

E-Print Network [OSTI]

Rick Grush Brain time and phenomenological time (draft) Page 1/37 Brain time and phenomenological "forthwith" in a common structure. - Edmund Husserl, Phenomenology of Inner Time Consciousness1 1 time and phenomenological time (draft) Page 2/37 information-processing structure that accounts

Grush, Rick

353

Tevatron injection timing  

SciTech Connect (OSTI)

Bunched beam transfer from one accelerator to another requires coordination and synchronization of many ramped devices. During collider operation timing issues are more complicated since one has to switch from proton injection devices to antiproton injection devices. Proton and antiproton transfers are clearly distinct sequences since protons and antiprotons circulate in opposite directions in the Main Ring (MR) and in the Tevatron. The time bumps are different, the kicker firing delays are different, the kickers and lambertson magnets are different, etc. Antiprotons are too precious to be used for tuning purposes, therefore protons are transferred from the Tevatron back into the Main Ring, tracing the path of antiprotons backwards. This tuning operation is called ``reverse injection.`` Previously, the reverse injection was handled in one supercycle. One batch of uncoalesced bunches was injected into the Tevatron and ejected after 40 seconds. Then the orbit closure was performed in the MR. In the new scheme the lambertson magnets have to be moved and separator polarities have to be switched, activities that cannot be completed in one supercycle. Therefore, the reverse injection sequence was changed. This involved the redefinition of TVBS clock event $D8 as MRBS $D8 thus making it possible to inject 6 proton batches (or coalesced bunches) and eject them one at a time on command, performing orbit closure each time in the MR. Injection devices are clock event driven. The TCLK is used as the reference clock. Certain TCLK events are triggered by the MR beam synchronized clock (MRBS) events. Some delays are measured in terms of MRBS ticks and MR revolutions. See Appendix A for a brief description of the beam synchronized clocks.

Saritepe, S.; Annala, G.

1993-06-01T23:59:59.000Z

354

Stigma trajectories among people living with HIV (PLHIV) embarking on a life time journey with antiretroviral drugs in Jinja, Uganda  

E-Print Network [OSTI]

therapy in Jinja, Uganda. Cult Health Sexuality 2011, 13(5):of HIV and AIDS in Rakai, Uganda. 19751990. Afr J AIDS Restested HIV negative in Uganda. Sociol Health Illn 2011, 36.

Mbonye, Martin; Nakamanya, Sarah; Birungi, Josephine; King, Rachel; Seeley, Janet; Jaffar, Shabbar

2013-01-01T23:59:59.000Z

355

Space time and rotations  

E-Print Network [OSTI]

The paper considers the problem of finding the metric of space time around a rotating, weakly gravitating body. Both external and internal metric tensors are consistently found, together with an appropriate source tensor. All tensors are calculated at the lowest meaningful approximation in a power series. The two physical parameters entering the equations (the mass and the angular momentum per unit mass) are assumed to be such that the mass effects are negligible with respect to the rotation effects. A non zero Riemann tensor is obtained. The order of magnitude of the effects at the laboratory scale is such as to allow for experimental verification of the theory.

A. Tartaglia

2002-01-04T23:59:59.000Z

356

Time-Resolved  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearchScheduled System BurstLong TermScience&Time-Resolved

357

SAMPLING AND MASS SPECTROMETRY APPROACHES FOR THE DETECTION OF DRUGS AND FOREIGN CONTAMINANTS IN BREATH FOR HOMELAND SECURITY APPLICATIONS  

SciTech Connect (OSTI)

Homeland security relies heavily on analytical chemistry to identify suspicious materials and persons. Traditionally this role has focused on attribution, determining the type and origin of an explosive, for example. But as technology advances, analytical chemistry can and will play an important role in the prevention and preemption of terrorist attacks. More sensitive and selective detection techniques can allow suspicious materials and persons to be identified even before a final destructive product is made. The work presented herein focuses on the use of commercial and novel detection techniques for application to the prevention of terrorist activities. Although drugs are not commonly thought of when discussing terrorism, narcoterrorism has become a significant threat in the 21st century. The role of the drug trade in the funding of terrorist groups is prevalent; thus, reducing the trafficking of illegal drugs can play a role in the prevention of terrorism by cutting off much needed funding. To do so, sensitive, specific, and robust analytical equipment is needed to quickly identify a suspected drug sample no matter what matrix it is in. Single Particle Aerosol Mass Spectrometry (SPAMS) is a novel technique that has previously been applied to biological and chemical detection. The current work applies SPAMS to drug analysis, identifying the active ingredients in single component, multi-component, and multi-tablet drug samples in a relatively non-destructive manner. In order to do so, a sampling apparatus was created to allow particle generation from drug tablets with on-line introduction to the SPAMS instrument. Rules trees were developed to automate the identification of drug samples on a single particle basis. A novel analytical scheme was also developed to identify suspect individuals based on chemical signatures in human breath. Human breath was sampled using an RTube{trademark} and the trace volatile organic compounds (VOCs) were preconcentrated using solid phase microextraction (SPME) and identified using gas chromatography - mass spectrometry (GC-MS). Modifications to the sampling apparatus allowed for increased VOC collection efficiency, and reduced the time of sampling and analysis by over 25%. The VOCs are present in breath due to either endogenous production, or exposure to an external source through absorption, inhalation, or ingestion. Detection of these exogenous chemicals can provide information on the prior location and activities of the subject. Breath samples collected before and after exposure in a hardware store and nail salon were analyzed to investigate the prior location of a subject; breath samples collected before and after oral exposure to terpenes and terpenoid compounds, pseudoephedrine, and inhalation exposure to hexamine and other explosive related compounds were analyzed to investigate the prior activity of a subject. The elimination of such compounds from the body was also monitored. In application, this technique may provide an early warning system to identify persons of interest in the prevention and preemption stages of homeland security.

Martin, A N

2009-01-27T23:59:59.000Z

358

Drug Testing for DOE Positions | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Year in Review: TopEnergy DOEDealingVehicle1 Closing the Circle: TheDraftfor $1.14 PerDrug

359

HAWC Timing Calibration  

E-Print Network [OSTI]

The High-Altitude Water Cherenkov (HAWC) Experiment is a second-generation highsensitivity gamma-ray and cosmic-ray detector that builds on the experience and technology of the Milagro observatory. Like Milagro, HAWC utilizes the water Cherenkov technique to measure extensive air showers. Instead of a pond filled with water (as in Milagro) an array of closely packed water tanks is used. The event direction will be reconstructed using the times when the PMTs in each tank are triggered. Therefore, the timing calibration will be crucial for reaching an angular resolution as low as 0.25 degrees.We propose to use a laser calibration system, patterned after the calibration system in Milagro. Like Milagro, the HAWC optical calibration system will use ~1 ns laser light pulses. Unlike Milagro, the PMTs are optically isolated and require their own optical fiber calibration. For HAWC the laser light pulses will be directed through a series of optical fan-outs and fibers to illuminate the PMTs in approximately one half o...

Huentemeyer, Petra; Dingus, Brenda

2009-01-01T23:59:59.000Z

360

Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung  

SciTech Connect (OSTI)

Particulate nanocarriers have been praised for their advantageous drug delivery properties in the lung, such as avoidance of macrophage clearance mechanisms and long residence times. However, instilled non-biodegradable polystyrene nanospheres with small diameters and thus large surface areas have been shown to induce pulmonary inflammation. This study examines the potential of biodegradable polymeric nanoparticles composed of poly(lactic-co-glycolic acid) (PLGA) and the novel PLGA derivative, diethylaminopropylamine polyvinyl alcohol-grafted-poly(lactic-co-glycolic acid) (DEAPA-PVAL-g-PLGA), to provoke inflammatory responses in the murine lung after intratracheal instillation. Lactate dehydrogenase (LDH) release, protein concentration, MIP-2 mRNA induction, and polymorphonucleocyte (PMN) recruitment in the bronchial alveolar lavage fluid (BALF) were used to evaluate an inflammatory response in Balb-C mice. Two sizes of polystyrene (PS) nanospheres (diameters: 75 nm and 220 nm) were included in the study for comparison. All nanoparticle suspensions were instilled at concentrations of 1 {mu}g/{mu}l and 2.5 {mu}g/{mu}l, representative of an estimated 'therapeutic dose' and a concentrated 'dose' of particles. In all experiments, the 75 nm PS particles exhibited elevated responses for the inflammatory markers investigated. In contrast, biodegradable particles of comparable hydrodynamic diameter showed a significantly lower inflammatory response. The most marked differences were observed in the extent of PMN recruitment. While the 75 nm and 220 nm PS nanospheres exhibited 41 and 74% PMN within the total BALF cell population after 24 h, respectively, PMN recruiting in lungs instilled with both types of biodegradable particles did not exceed values of the negative isotonic glucose control. In conclusion, evidence suggests that biodegradable polymeric nanoparticles designed for pulmonary drug delivery may not induce the same inflammatory response as non-biodegradable polystyrene particles of comparable size.

Dailey, L.A. [Department of Pharmaceutics and Biopharmacy, Philipps-University, D-35037 Marburg (Germany)]. E-mail: lea_ann.dailey@kcl.ac.uk; Jekel, N. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Fink, L. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Gessler, T. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Schmehl, T. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Wittmar, M. [Department of Pharmaceutics and Biopharmacy, Philipps-University, D-35037 Marburg (Germany); Kissel, T. [Department of Pharmaceutics and Biopharmacy, Philipps-University, D-35037 Marburg (Germany); Seeger, W. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany)

2006-08-15T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Real time automated inspection  

DOE Patents [OSTI]

A method and apparatus are described relating to the real time automatic detection and classification of characteristic type surface imperfections occurring on the surfaces of material of interest such as moving hot metal slabs produced by a continuous steel caster. A data camera transversely scans continuous lines of such a surface to sense light intensities of scanned pixels and generates corresponding voltage values. The voltage values are converted to corresponding digital values to form a digital image of the surface which is subsequently processed to form an edge-enhanced image having scan lines characterized by intervals corresponding to the edges of the image. The edge-enhanced image is thresholded to segment out the edges and objects formed by the edges by interval matching and bin tracking. Features of the objects are derived and such features are utilized to classify the objects into characteristic type surface imperfections. 43 figs.

Fant, K.M.; Fundakowski, R.A.; Levitt, T.S.; Overland, J.E.; Suresh, B.R.; Ulrich, F.W.

1985-05-21T23:59:59.000Z

362

Time encoded radiation imaging  

DOE Patents [OSTI]

The various technologies presented herein relate to detecting nuclear material at a large stand-off distance. An imaging system is presented which can detect nuclear material by utilizing time encoded imaging relating to maximum and minimum radiation particle counts rates. The imaging system is integrated with a data acquisition system that can utilize variations in photon pulse shape to discriminate between neutron and gamma-ray interactions. Modulation in the detected neutron count rates as a function of the angular orientation of the detector due to attenuation of neighboring detectors is utilized to reconstruct the neutron source distribution over 360 degrees around the imaging system. Neutrons (e.g., fast neutrons) and/or gamma-rays are incident upon scintillation material in the imager, the photons generated by the scintillation material are converted to electrical energy from which the respective neutrons/gamma rays can be determined and, accordingly, a direction to, and the location of, a radiation source identified.

Marleau, Peter; Brubaker, Erik; Kiff, Scott

2014-10-21T23:59:59.000Z

363

Deciding Timed Bisimulation for Timed Automata Using Zone Valuation Graph  

E-Print Network [OSTI]

Deciding Timed Bisimulation for Timed Automata Using Zone Valuation Graph Shibashis Guha, Chinmay was first proved to be decidable for timed automata by Cerans using a product construction method on region graph. Several other methods have been proposed in the literature since then for decid- ing timed

Prasad, Sanjiva

364

Gas generation and retention in Tank 101-SY: A summary of laboratory studies, tank data, and information needs  

SciTech Connect (OSTI)

Chemical and radioactive wastes from processes used to separate plutonium from uranium are stored in underground tanks at the Hanford Site in Washington state. In March 1981, it was observed that the volume of wastes in Tank 101-SY slowly increased, followed by a rapid decrease and the venting of large quantities of gases. These cycles occurred every 8 to 15 weeks and continue to the present time. Subsequent analyses showed that these gases were composed primarily of hydrogen and nitrous oxide (N{sub 2}O). In response to the potential for explosion and release of hazardous materials to the environment, laboratory programs were initiated at Argonne National Laboratory (ANL), Georgia Institute of Technology (GIT), Pacific Northwest Laboratory (PNL), and Westinghouse Hanford Company (WHC), to develop a better understanding of the physical and chemical processes occurring in this waste tank. An aggressive sampling and analysis effort is also under way to characterize the wastes as fully as possible. These efforts will provide a technically defensible basis for safety analyses and future mitigation/remediation of the tank and its contents.

Pederson, L.R. [comp.] [Pacific Northwest Lab., Richland, WA (United States); Ashby, E.C. [Georgia Inst. of Tech., Atlanta, GA (United States); Jonah, C.; Meisel, D. [Argonne National Lab., IL (United States); Strachan, D.M. [Pacific Northwest Lab., Richland, WA (United States)

1992-06-01T23:59:59.000Z

365

A client management system for criminal justice referrals to drug abuse treatment  

E-Print Network [OSTI]

. These modalities included methadone maintenance (MM), outpatient drug-free (DF), therapeutic community (TC), and short-term detoxification (DT). In a review of findings in 1979, Sel ls described each of the four modalities. Methadone maintenance programs... over the years of research. Therapeutic communities are typically residential, drug-free programs offering 24-hour care and they concentrate on rehabilitation through resocialization of the addict toward more adaptive and productive pursuits. Drug...

Pate, Wayland Gordon

2012-06-07T23:59:59.000Z

366

E-Print Network 3.0 - anti-inflammatory drug naproxen Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

lists available at ScienceDirect Summary: ; Dextromethorphan, a drug commonly used as cough suppressant; Naproxen and Flurbiprofen, two widespread anti... of Naproxen. This makes...

367

E-Print Network 3.0 - antipsychotic drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 38 PHARMACOGENETICS OF PARKINSONISM, RIGIDITY, Summary: Fleischhacker, W.W., Meise, U., Gunther, V., and Kurz, M. (1994). Compliance with antipsychotic drug...

368

E-Print Network 3.0 - antimicrobial drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

369

E-Print Network 3.0 - antimicrobial drug resistanceestudio Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

370

E-Print Network 3.0 - aetiology antimicrobial drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

371

E-Print Network 3.0 - anticancer drug cisplatin Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

on mitochondrial oxygen consumption Abdul-Kader Souida... June 2003 Abstract The evolving role of mitochondria as a target for many anticancer drugs (e... DNA platination by...

372

E-Print Network 3.0 - acetaminophen drug particles Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3945 Contents lists available at ScienceDirect Summary: ; Lee, 2007; Mullier et al., 1991). Measurements of the friction between drug and excipient particles... the conveying,...

373

E-Print Network 3.0 - anti-malarial drug precursor Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

374

E-Print Network 3.0 - anti-malarial drug quality Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

375

E-Print Network 3.0 - anti-malarial drug sensitivity Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

376

E-Print Network 3.0 - adverse drug interactions Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sciences and Ecology 12 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School Summary: ; Early labels decorative Drug...

377

E-Print Network 3.0 - antibacterial drug resistances Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Exposing plasmids as the Achilles' heel of drug-resistant bacteria Summary: in the pharmaceutical industry away from the development of novel antibacterials 4,5. New...

378

E-Print Network 3.0 - anti-infective drugs advisory Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

drug classes of anti-infectives and their mechanisms of action... advisory role or in the pharmaceutical industry. An interest in antibiotic prescribing practice... changes to...

379

E-Print Network 3.0 - anticholinergic antiparkinson drugs Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

4 5 > >> 1 Arch Intern Med . Author manuscript Drugs with anticholinergic properties, cognitive decline, and dementia in Summary: Arch Intern Med . Author manuscript Page 1 14...

380

E-Print Network 3.0 - antiviral drug acyclovir Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 3 European consensus on viral encephalitis Herpes simplex encephalitis (HSE) is one of the Summary: management, HSE does respond to specific antiviral drugs, and...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

E-Print Network 3.0 - antiepileptic drugs compelling Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

compelling Search Powered by Explorit Topic List Advanced Search Sample search results for: antiepileptic drugs compelling Page: << < 1 2 3 4 5 > >> 1 Folic acid sensitive birth...

382

E-Print Network 3.0 - antiepileptic drugs increase Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

increase Search Powered by Explorit Topic List Advanced Search Sample search results for: antiepileptic drugs increase Page: << < 1 2 3 4 5 > >> 1 Folic acid sensitive birth...

383

E-Print Network 3.0 - anti-hiv drug regimens Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

body's natural anti-HIV immune... , there are no therapeutic HIV vaccines approved by the Food and DrugAdministration (FDA). However, therapeutic HIV vaccines... response, people...

384

E-Print Network 3.0 - animal drug availability Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: of various origins (e.g. viral hepatitis; chronic intoxication by alcohol, chemicals or drugs; Wilson... architecture and hepatic organ function. Up till now, no...

385

E-Print Network 3.0 - anticancer drug ellipticine Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Institute, University of Toronto Collection: Biology and Medicine 15 Chemical Data Mining of the NCI Human Tumor Cell Line Database Huijun Wang Summary: in drug discovery...

386

E-Print Network 3.0 - anticancer drug discovery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 From the University of Mississippi Medical Center Division of Public Affairs ANTI-CANCER DRUG DISCOVERY PARTNERSHIP FORMED BETWEEN UMMC CANCER INSTITUTE AND Summary: From the...

387

E-Print Network 3.0 - adrs adverse drug Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sciences and Ecology 29 List of publications related to pharmavovigilance Summary: , Stricker BHC. Attitudinal survey of voluntary reporting of adverse drug reactions. Br J Clin...

388

E-Print Network 3.0 - antihypertensive drug treatment Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the medical treatment of vascular risk factors. Cardiovasc Drugs Ther 2005 Dec... , Stricker BHC, Leufkens HGM, de Boer A. Methods to assess intended effects of ... Source:...

389

E-Print Network 3.0 - antimalaria drug mefloquine Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EP van, Heeringa M. Bijwerkingen van mefloquine. Onrust ondermijnt objectieve... , Stricker BHC. Attitudinal survey of voluntary reporting of adverse drug reactions. Br J Clin...

390

antiparkinsonian drug-induced sleepiness: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lpez-ortega; M Carmen Lpez-vega; M Isabel Lucena; Clinical Pharmacology Service; Virgen De La 35 Drug-induced pruritic micropapular eruption: anastrozole, a commonly used...

391

E-Print Network 3.0 - atovaquone drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

spontaneously arising muta- tions that confer resistance to the drug 39. In principle... the molecular basis of atovaquone resistance in parasites and ... Source: Trumpower,...

392

Direct encapsulation of water-soluble drug into silica microcapsules for sustained release applications  

SciTech Connect (OSTI)

Direct encapsulation of water-soluble drug into silica microcapsules was facilely achieved by a sol-gel process of tetraethoxysilane (TEOS) in W/O emulsion with hydrochloric acid (HCl) aqueous solution containing Tween 80 and drug as well as cyclohexane solution containing Span 80. Two water-soluble drugs of gentamicin sulphate (GS) and salbutamol sulphate (SS) were chosen as model drugs. The characterization of drug encapsulated silica microcapsules by scanning electronic microscopy (SEM), FTIR, thermogravimetry (TG) and N{sub 2} adsorption-desorption analyses indicated that drug was successfully entrapped into silica microcapsules. The as-prepared silica microcapsules were uniform spherical particles with hollow structure, good dispersion and a size of 5-10 {mu}m, and had a specific surface area of about 306 m{sup 2}/g. UV-vis and thermogravimetry (TG) analyses were performed to determine the amount of drug encapsulated in the microcapsules. The BJH pore size distribution (PSD) of silica microcapsules before and after removing drug was examined. In vitro release behavior of drug in simulated body fluid (SBF) revealed that such system exhibited excellent sustained release properties.

Wang Jiexin; Wang Zhihui [Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Chen Jianfeng [Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029 (China)], E-mail: chenjf@mail.buct.edu.cn; Yun, Jimmy [Nanomaterials Technology Pte. Ltd., 28 Ayer Rajah Crescent 03-03, Singapore 139959 (Singapore)

2008-12-01T23:59:59.000Z

393

E-Print Network 3.0 - antithyroid drugs Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Perchlorate Drugs like tamoxifen, nafoxidine Persistent organic pollutants such as dioxins... water sup- plies have measurable levels of residues from various prescription...

394

anti-hiv drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

395

anti-parkinsonian drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

396

E-Print Network 3.0 - anti-tuberculosis drug resistance Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University Collection: Biology and Medicine 10 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

397

E-Print Network 3.0 - anti-inflammatory drug-induced ulcer Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

<< < 1 2 3 4 5 > >> Page: << < 1 2 3 4 5 > >> 61 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: episodic arthritis, which...

398

E-Print Network 3.0 - anti-inflammatory drug etoricoxib Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Vanderbilt University Collection: Biology and Medicine ; Chemistry 4 Management of gout Chapter 2.1 Summary: - inflammatory drugs (glucocorticosteroids, colchicine, and...

399

E-Print Network 3.0 - anti-tuberculosis drug ethionamide Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Harvard University Collection: Biology and Medicine 5 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

400

E-Print Network 3.0 - antituberculosis drug resistance Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

British Columbia Collection: Biology and Medicine 12 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: Practice research in the...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

E-Print Network 3.0 - antituberculosis drugs carriers Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Harvard University Collection: Biology and Medicine 3 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: Practice research in the...

402

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico  

E-Print Network [OSTI]

Rapid advancing computational technologies have greatly speeded up the development of computer-aided drug design (CADD). Recently, pharmaceutical companies have increasingly shifted their attentions toward traditional ...

Chen, Yu-Chian

403

E-Print Network 3.0 - antiepileptic drugs carbamazepine Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for: antiepileptic drugs carbamazepine Page: << < 1 2 3 4 5 > >> 1 Folic acid sensitive birth defects in association with intrauterine exposure to folic acid Summary: to...

404

Reporting Prescription Drugs, Over-the-Counter Medications, and Dietary Supplements  

SciTech Connect (OSTI)

Overview of types of prescription drugs and over-the-counter medications that must be reported in DOE's Human Reliability Program.

Center for Human Reliability Studies

2008-02-01T23:59:59.000Z

405

E-Print Network 3.0 - alphavirus antiviral drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

that depends on the PARP domain may guide future strategies for therapeutic drug design to treat alphavirus... -finger antiviral protein inhibits alphavirus ... Source:...

406

E-Print Network 3.0 - antiplatelet drugs resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to microscopy development, bioengineering to drug design use Jennifer's talk as a guide to illustrate uses... thinners taken by mouth may be prescribed later to prevent clots...

407

E-Print Network 3.0 - antiviral drug design Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Pharmacology and Pharmaceutical Sciences. his research interests include drug design and discovery, database mining of small- Summary: an internationally recognized...

408

Adverse Drug Reaction Monitoring In Psychiatric OPD Adverse Drug Reaction Monitoring In Psychiatric Outpatient Department Of A Tertiary Care Hospital  

E-Print Network [OSTI]

Abstracts Background:Pharmacovigilance in psychiatry units can play vital role in detecting adverse drug reactions (ADRs) and alerting physician to such events, thereby protecting the user population from avoidable harm. Objective: To assess the suspected ADRs profile of psychotropic drugs in psychiatry OPD of a tertiary care hospital and its comparison with available literature data as well as to create awareness among the consultant psychiatrists to these ADRs profile. Materials and Methods: A prospective study was conducted in the psychiatry OPD. Thirty five consecutive patients per day were screened irrespective of their psychiatric diagnosis for suspected ADRs on 3 fixed days in a week from January 2011 to December 2011. CDSCO form was used to record the ADRs. Causality was assessed by WHO causality assessment scale while severity was assessed using Hartwig and Siegel scale. Results: Out of 4410 patients were screened, 383 patients were suspected of having at least one ADR. Thus, 8.68 % of our study population reported ADRs. Of 407 events recorded, 369(90.60%) were probable and rest possible according to WHO-UMC causality assessment

Hiren K. Prajapati; Nisarg D. Joshi; Hiren R. Trivedi; Manubhai C. Parmar; Shilpa P. Jadav; Dinesh M. Parmar; Jalpan G. Kareliya

409

SLH Timing Belt Powertrain  

SciTech Connect (OSTI)

The main goal of this proposal was to develop and test a novel powertrain solution for the SLH hydroEngine?, a low-cost, efficient low-head hydropower technology. Nearly two-thirds of U.S. renewable electricity is produced by hydropower (EIA 2010). According to the U.S. Department of Energy; this amount could be increased by 50% with small hydropower plants, often using already-existing dams (Hall 2004). There are more than 80,000 existing dams, and of these, less than 4% generate power (Blankinship 2009). In addition, there are over 800 irrigation districts in the U.S., many with multiple, non-power, low-head drops. These existing, non-power dams and irrigation drops could be retrofitted to produce distributed, baseload, renewable energy with appropriate technology. The problem is that most existing dams are low-head, or less than 30 feet in height (Ragon 2009). Only about 2% of the available low-head hydropower resource in the U.S. has been developed, leaving more than 70 GW of annual mean potential low-head capacity untapped (Hall 2004). Natel Energy, Inc. is developing a low-head hydropower turbine that operates efficiently at heads less than 6 meters and is cost-effective for deployment across multiple low-head structures. Because of the unique racetrack-like path taken by the prime-movers in the SLH, a flexible powertrain is required. Historically, the only viable technological solution was roller chain. Despite the having the ability to easily attach blades, roller chain is characterized by significant drawbacks, including high cost, wear, and vibration from chordal action. Advanced carbon-#12;fiber-reinforced timing belts have been recently developed which, coupled with a novel belt attachment system developed by Natel Energy, result in a large reduction in moving parts, reduced mass and cost, and elimination of chordal action for increased fatigue life. The work done in this project affirmatively addressed each of the following 3 major uncertainties concerning a timing-belt based hydroEngine ?powertrain: 1. Can a belt handle the high torques and power loads demanded by the SLH? (Yes.) 2. Can the SLH blades be mounted to belt with a connection that can withstand the loads encountered in operation? (Yes.) 3. Can the belt, with blade attachments, live through the required cyclic loading? (Yes.) The research adds to the general understanding of sustainable small hydropower systems by using innovative system testing to develop and demonstrate performance of a novel powertrain solution, enabling a new type of hydroelectric turbine to be commercially developed. The technical effectiveness of the methods investigated has been shown to be positive through an extensive design and testing process accommodating many constraints and goals, with a major emphasis on high cycle fatigue life. Economic feasibility of the innovations has been demonstrated through many iterations of design for manufacturability and cost reduction. The project is of benefit to the public because it has helped to develop a solution to a major problem -- despite the large available potential for new low-head hydropower, high capital costs and high levelized cost of electricity (LCOE) continue to be major barriers to project development. The hydroEngine? represents a significant innovation, leveraging novel fluid mechanics and mechanical configuration to allow lower-cost turbine manufacture and development of low head hydropower resources.

Schneider, Abe

2014-04-09T23:59:59.000Z

410

Report on the deuterium retention in CVD coated W on SiC in support of the Ultramet Companys Small Business Innovation Research (SBIR) project: SOW DE-FG02-07ER84941  

SciTech Connect (OSTI)

A tungsten (W) coated (0.0005-inch thickness) silicon carbide (SiC) (1.0-inch diameter and 0.19-inch thickness) sample was exposed to a divertor relevant high-flux (~1022 m-2s-1) deuterium plasma at 200 and 400C in the Idaho National Laboratorys (INLs) Tritium Plasma Experiment (TPE), and the total deuterium retention was subsequently measured via the thermal desorption spectroscopy (TDS) method. The deuterium retentions were 6.4x1019 m-2 and 1.7x1020 m-2, for 200 and 400C exposure, respectively. The Tritium Migration Analysis Program (TMAP) was used to analyze the measured TDS spectrum to investigate the deuterium behavior in the W coated SiC, and the results indicated that most of the deuterium was trapped in the W coated layer even at 400C. This thin W layer (0.0005-inch ~ 13m thickness) prevented deuterium ions from bombarding directly into the SiC substrate, minimizing erosion of SiC and damage creation via ion bombardment. The shift in the D desorption peak in the TDS spectra from 200 C to 400C can be attributed to D migration to the bulk material. This unexpectedly low deuterium retention and short migration might be due to the porous nature of the tungsten coating, which can decrease the solution concentration of deuterium atoms.

Masashi Shimada

2012-06-01T23:59:59.000Z

411

Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery  

E-Print Network [OSTI]

Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what ...

Vukmirovic, Neda

2007-01-01T23:59:59.000Z

412

First-passage-time problems in time-aware networks  

E-Print Network [OSTI]

First passage time or the first time that a stochastic process crosses a boundary is a random variable whose probability distribution is sought in engineering, statistics, finance, and other disciplines. The probability ...

Suwansantisuk, Watcharapan, 1978-

2012-01-01T23:59:59.000Z

413

Turbo Space-Time Codes with Time Varying Linear Transformations  

E-Print Network [OSTI]

1 Turbo Space-Time Codes with Time Varying Linear Transformations Hangjun Chen and Alexander 07102 Email: {hangjun.chen; alexander.m.haimovich}@njit.edu Abstract Turbo space-time codes with symbols in this paper. It is shown that turbo codes with TVLT achieve full diversity gain and do not require exhaustive

Haimovich, Alexander

414

Modern theories of discrete time  

E-Print Network [OSTI]

We review some modern theories about the structure of space and time, in particular those related to discrete space and time. Following an epistemological method we start from theories which discuss discrete space and time as a mathematical tool to solve physical models. Antother theories look for physical content of the discrete structure of space and time, based in relational theories of space and time which are derived from the relations of some fundamental entities. Finally we present some philosophical positions who try to find the ontological foundation of the relational theories os space and time.

M. Lorente

2003-12-31T23:59:59.000Z

415

Data Warehouse Design for Pharmaceutical Drug Discovery Research Melinda G. Axel and Il-Yeol Song  

E-Print Network [OSTI]

an analysis of the principal activities involved in drug discovery in the pharmaceutical industry, and a setData Warehouse Design for Pharmaceutical Drug Discovery Research Melinda G. Axel and Il-Yeol Song: axel@superlink.net, songiy@post.drexel.edu Abstract Pharmaceutical companies spend billions of dollars

Song, Il-Yeol

416

Blood Brain Barrier group Multi drug resistance and P-glycoprotein efflux transporter: physiological roles and  

E-Print Network [OSTI]

1 Blood Brain Barrier group Multi drug resistance and P-glycoprotein efflux transporter-binding cassette) transporter family expressed in many tissue barriers (e.g. gut, lung, blood-brain barrier of many drugs to the brain and has been the subject of intensive research in the last 10 years

Applebaum, David

417

Techniques to Improve the Characterization of Protein Particles in Biologic Drug Products  

E-Print Network [OSTI]

are the characterization of these particles using material sparing approaches and the effect of the presence of silicone oil particles on protein solutions. With the focus on high concentration drug products (50 mg/mL), and the drive toward conserving drug product...

Toler, Maria

2012-08-31T23:59:59.000Z

418

Endovascular Treatment of a Vertebral Artery Pseudoaneurysm in a Drug User  

SciTech Connect (OSTI)

A 26-year-old drug abuser who presented with sepsis was found to have a pseudoaneurysm in the left vertebral artery. This aneurysm was presumed to be post-traumatic, since the patient reported multiple attempts to inject drugs in the left jugular vein 15 days prior to admission. The pseudoaneurysm was treated effectively with stent-graft placement.

Mourikis, Dimitrios; Chatziioannou, Achilleas; Doriforou, Ortansia; Skiadas, Vasilios, E-mail: bill_skiadas@yahoo.gr; Koutoulidis, Vasilios [Areteion Hospital, University of Athens, Department of Radiology (Greece); Katsenis, Konstantinos [Areteion Hospital, University of Athens, Department of Vascular Surgery (Greece); Vlahos, Lampros [Areteion Hospital, University of Athens, Department of Radiology (Greece)

2006-08-15T23:59:59.000Z

419

Development of an inventory/archive program for the retention, management, and disposition of tank characterization samples at the 222-S laboratory  

SciTech Connect (OSTI)

The Hanford Tank Waste Remediation Systems (TWRS) Characterization Program is responsible for coordinating the sampling and analysis of the 177 large underground storage tanks at the Hanford site. The 222-S laboratory has been the primary laboratory for chemical analysis of this highly-radioactive material and has been accumulating these samples for many years. As part of the Fiscal Year 1998 laboratory work scope, the 222-S laboratory has performed a formal physical inventory of all tank characterization samples which are currently being stored. In addition, an updated inventory/archive program has been designed. This program defines sample storage, retention, consolidation, maintenance, and disposition activities which will ensure that the sample integrity is preserved to the greatest practical extent. In addition, the new program provides for continued availability of waste material in a form which will be useful for future bench-scale studies. Finally, when the samples have exceeded their useful lifetime, the program provides for sample disposition from,the laboratory in a controlled, safe and environmentally compliant manner. The 222-S laboratory maintains custody over samples of tank waste material which have been shipped to the laboratory for chemical analysis. The storage of these samples currently requires an entire hotcell, fully dedicated to sample archive storage, and is rapidly encroaching on additional hotcell space. As additional samples are received, they are beginning to limit the 222-S laboratory hotcell utility for other activities such as sample extrusion and subsampling. The 222-S laboratory tracks the number of sample containers and the mass of each sample through an internal database which has recently been verified and updated via a physical inventory.

Seidel, C.M.

1998-04-29T23:59:59.000Z

420

architecture morphogenesis drug: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Abstract. In his pioneering 1952 paper, The chemical basis of morphogenesis, Alan Turing introduced, perhaps for the first time, a model of the morphogenesis of embryo...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Flow cytometry aids basic cell biology research and drug discovery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

including very deep wells already producing oil and gas and drilling operations for new wells. Wireless technology collects real-time information from oil and gas wells April,...

422

Time machines and quantum theory  

E-Print Network [OSTI]

There is a deep structural link between acausal spacetimes and quantum theory. As a consequence quantum theory may resolve some "paradoxes" of time travel. Conversely, non-time-orientable spacetimes naturally give rise to electric charges and spin half. If an explanation of quantum theory is possible, then general relativity with time travel could be it.

Mark J Hadley

2006-12-02T23:59:59.000Z

423

Impulsivity in disorders of food and drug misuse  

E-Print Network [OSTI]

-time by the University of Cambridge and part-time by GSK PLC and is a shareholder of GSK. TWR is a consultant for Cambridge Cognition, Eli Lilly, GSK, Merck, Sharpe and Dohme, Lundbeck, Teva and Shire Pharmaceuticals. He is or has been in receipt of research grants...

Mole, T. B.; Irvine, M. A.; Worbe, Y.; Collins, P.; Mitchell, S. P.; Bolton, S.; Harrison, N. A.; Robbins, T. W.; Voon, V.

2014-08-14T23:59:59.000Z

424

Experimental and computational investigations of therapeutic drug release from biodegradable poly(lactide-co-glycolide) (plg) microspheres  

E-Print Network [OSTI]

The need to tailor release-rate profiles from polymeric microspheres remains one of the leading challenges in controlled drug delivery. Microsphere size, which has a significant effect on drug release rate, can potentially be varied to design a...

Berchane, Nader Samir

2009-05-15T23:59:59.000Z

425

Report: Employee Recruitment and Retention  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power.pdf11-161-LNG |September 15,2015Department of Energy onACQUISITION ANDEMEMU.S.EMPLOYEE

426

Sample Retention Incentive Service Agreement  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAXBalancedDepartmentRestrictionsExample Sheet) | Department of|Products |: Phased

427

Protections: Sediment Control = Contaminant Retention  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 - SeptemberMicroneedles for4-16HamadaBaO/Al2O3Protecting Lab land

428

Reactor control rod timing system  

SciTech Connect (OSTI)

A fluid driven jet-edge whistle timing system for control rods of a nuclear reactor for producing real-time detection of the timing of each control rod in its scram operation. An important parameter in reactor safety, particularly for liquid metal fast breeder reactors (LMFBR), is the time deviation between the time the control rod is released and the time the rod actually reaches the down position. The whistle has a nearly pure tone signal with center frequency (Above 100 kHz) far above the frequency band in which the energy of the background noise is concentrated. Each control rod can be fitted with a whistle with a different frequency so that there is no ambiguity in differentiating the signal from each control rod.

Wu, P.T.

1982-02-09T23:59:59.000Z

429

Reactor control rod timing system  

DOE Patents [OSTI]

A fluid driven jet-edge whistle timing system for control rods of a nuclear reactor for producing real-time detection of the timing of each control rod in its scram operation. An important parameter in reactor safety, particularly for liquid metal fast breeder reactors (LMFBR), is the time deviation between the time the control rod is released and the time the rod actually reaches the down position. The whistle has a nearly pure tone signal with center frequency (above 100 kHz) far above the frequency band in which the energy of the background noise is concentrated. Each control rod can be fitted with a whistle with a different frequency so that there is no ambiguity in differentiating the signal from each control rod.

Wu, Peter T. K. (Clifton Park, NY)

1982-01-01T23:59:59.000Z

430

Campus Health/forms/2013,06,07 AGREEMENT TO SUBMIT TO AN ALCOHOL AND/OR DRUG TEST  

E-Print Network [OSTI]

Campus Health/forms/2013,06,07 AGREEMENT TO SUBMIT TO AN ALCOHOL AND/OR DRUG TEST AND AUTHORIZATION FOR THE RELEASE OF TEST RESULTS I have been requested by LSUHSC to submit to an alcohol and/or drug test and/or drug test is completely voluntary on my part and that I have the right to refuse to submit

431

IT'S ABOUT TIME Characteristic times in biogeochemistry and climate  

E-Print Network [OSTI]

, and then It falls to earth: Can you tell me when? Decision making on energy and climate change #12;Impulse responseIT'S ABOUT TIME Characteristic times in biogeochemistry and climate Stephen E. Schwartz Symposium on biogeochemical cycling and climate In honor of Henning Rodhe on the occasion of his retirement from the chair

Schwartz, Stephen E.

432

Real-Time Control with Parametric Timed Reachability Games  

E-Print Network [OSTI]

for which the existence of a parameter valuation, such that there is a strategy for the controller to reach set of parameter valuations. Keywords: Timed automata, game theory, parameters, control, verification, model-checking 1. INTRODUCTION Formal methods are widely used in the analysis of time critical systems

Boyer, Edmond

433

Subsystem real-time Time Dependent Density Functional Theory  

E-Print Network [OSTI]

We present the extension of Frozen Density Embedding (FDE) theory to real-time Time Dependent Density Functional Theory (rt-TDDFT). FDE a is DFT-in-DFT embedding method that allows to partition a larger Kohn-Sham system into a set of smaller, coupled Kohn-Sham systems. Additional to the computational advantage, FDE provides physical insight into the properties of embedded systems and the coupling interactions between them. The extension to rt-TDDFT is done straightforwardly by evolving the Kohn-Sham subsystems in time simultaneously, while updating the embedding potential between the systems at every time step. Two main applications are presented: the explicit excitation energy transfer in real time between subsystems is demonstrated for the case of the Na$_4$ cluster and the effect of the embedding on optical spectra of coupled chromophores. In particular, the importance of including the full dynamic response in the embedding potential is demonstrated.

Krishtal, Alisa; Pavanello, Michele

2015-01-01T23:59:59.000Z

434

Myeloablative 131I-Tositumomab Radioimmunotherapy in Treating Non-Hodgkins Lymphoma: Comparison of Dosimetry Based on Whole-Body Retention and Dose to Critical Organ Receiving the Highest Dose  

SciTech Connect (OSTI)

Objectives: Myeloablative radioimmunotherapy (RIT) using 131I tositumomab (anti-CD 20) monoclonal antibodies is an effective new therapy for B-cell non-Hodgkins lymphoma (NHL). The goal of this work is to determine optimum methods to deliver maximal myeloablative radioactivity without exceeding the radiation tolerance of critical normal organs such as liver and lungs, and avoiding serious toxicity. Methods: We reviewed dosimetry records for 100 consecutive patients who underwent biodistribution and dosimetry after a test infusion of 131I- tositumomab. Serial gamma camera images were used to determine organ and tissue activities over time and to calculate radiation-absorbed doses. Volumes of critical normal organs were determined from CT scans to adjust the dose estimates for the individual patient. These dose estimates helped us determine an appropriate therapy based on projected dose to the critical normal organ receiving a maximum tolerable radiation dose. We compared our method of organ-specific dosimetry for treatment planning with the standard clinical approaches using a whole-body dose-assessment method by assessing the difference in projected amounts of radiation-absorbed doses, as well as the ratios of projected amounts, that would be prescribed for therapy by each of these two strategies. Results: The mean organ doses (mGy/MBq) estimated by both methods were (1) Whole body method: liver = 0.33 and lungs = 0.33; and (2) Organ-specific method: liver 1.52 and lungs 1.72 (p = .0001). The median difference between the radiation-absorbed dose estimates was 3.40 (range of 1.37 to 7.96) for the lungs, 3.05 (range of 1.04 to 6.20) for the liver, and 0.05 for whole body (range of 0.18 to 0.16). The median ratio (OS divided by WB method) of radiation-absorbed dose estimates was 5.12 (range of 2.33 to 10.01) for the lungs, 4.14 (range of 2.16 to 6.67) for the liver, and 0.94 (range of 0.79 to 1.22) for whole body. There was significant difference between the dose estimated by the two methods for liver and lungs (p = 0.0001) and a significant correlation for whole body dose estimates by the two methods (R = 0.97) indicating confidence in the whole body dose estimation methods. Conclusions: Dosimetry based only on whole body retention will under-estimate the organ doses in a substantial number of patients, likely because it assumes a uniform distribution and clearance without accounting for patient-specific variations in biodistribution. Myeloablative treatment based on individual organ radiation absorbed dose provides the ability to safely administer the largest possible amounts of radioactivity and deliver an optimized radiation dose to tumor within the tolerance of normal organs.

Rajendran, Joseph G.; Gopal, Ajay K.; Fisher, Darrell R.; Durack, L. D.; Gooley, Ted; Press, Oliver W.

2008-05-01T23:59:59.000Z

435

Resource Allocation with Time Intervals  

E-Print Network [OSTI]

Keywords: resource allocation, proper intervals, unsplittable flow ... be positioned within a larger time interval) and call admission control, see [4] and [8] for...

2009-09-21T23:59:59.000Z

436

A continuous GRASP to determine the relationship between drugs and adverse reactions  

SciTech Connect (OSTI)

Adverse drag reactions (ADRs) are estimated to be one of the leading causes of death. Many national and international agencies have set up databases of ADR reports for the express purpose of determining the relationship between drugs and adverse reactions that they cause. We formulate the drug-reaction relationship problem as a continuous optimization problem and utilize C-GRASP, a new continuous global optimization heuristic, to approximately determine the relationship between drugs and adverse reactions. Our approach is compared against others in the literature and is shown to find better solutions.

Hirsch, Michael J. [Raytheon, Inc., Network Centric Systems, P.O. Box 12248, St. Petersburg, FL, 33733 (United States); Meneses, Claudio N.; Pardalos, Panos M.; Ragle, Michelle [Department of Industrial and Systems Engineering, University of Florida, 303 Weil Hall, Gainesville, FL, 32611 (United States); Resende, Mauricio G. C. [Algorithms and Optimization Research Department, AT and T Labs Research, 180 Park Avenue, Room C241, Florham Park, NJ 07932 (United States)

2007-11-05T23:59:59.000Z

437

Electric Time in Quantum Cosmology  

E-Print Network [OSTI]

Effective quantum cosmology is formulated with a realistic global internal time given by the electric vector potential. New possibilities for the quantum behavior of space-time are found, and the high-density regime is shown to be very sensitive to the specific form of state realized.

Stephon Alexander; Martin Bojowald; Antonino Marciano; David Simpson

2012-12-10T23:59:59.000Z

438

STARBASE: MANAGING CONTENTION AND TIMING  

E-Print Network [OSTI]

systems (RT­DBMS) has primarily based on simulation. This chapter discusses how current real­time technology has been applied to architect an actual RT­DBMS on a real­time microkernel operating system. A real RT­DBMS must confront many practical issues which simulations typically ignore: race conditions

Son, Sang H.

439

Time for money? Prathap Haridoss  

E-Print Network [OSTI]

Time for money? Prathap Haridoss "The more money you earn, the less time you will have to spend, you have to keep enquiring around. To get the maximum money that you possibly can get, you can't just `get a salary', you have to actively work towards increasing your income. Making money can be a full

Krishnapura, Nagendra

440

Lack of effect of spinal anesthesia on drug metabolism  

SciTech Connect (OSTI)

The effect of spinal anesthesia on drug disposition was determined in six dogs with chronically implanted vascular catheters using propranolol as a model compound. On the first study day, 40 mg of unlabeled propranolol and 200 microCi of (3H)propranolol were injected into the portal and femoral veins respectively. Arterial blood samples were taken for 4 hr for measurement of plasma concentrations of labeled and unlabeled propranolol by high-pressure liquid chromatography (HPLC) and of (3H)propranolol by liquid scintillation counting of the HPLC eluant corresponding to each propranolol peak. Twenty-four hr later, spinal anesthesia was induced with tetracaine (mean dose 20.7 +/- 0.6 mg) with low sacral to midthoracic levels and the propranolol infusions and sampling were then repeated. Spinal anesthesia had no significant effect on either the intrinsic clearance of propranolol (2.01 +/- 0.75 L/min before and 1.9 +/- 0.7 L/min during spinal anesthesia), or on mean hepatic plasma flow (2.01 +/- 0.5 L/min before and 1.93 +/- 0.5 L/min during spinal anesthesia). The systemic clearance and elimination half-life of propranolol were also unchanged by spinal anesthesia (0.9 +/- 0.23 L/min on the first day, 0.7 +/- 0.1 L/min during spinal anesthesia; and 101 +/- 21 min on the first day, 115 +/- 16 min during spinal anesthesia, respectively). The volume of distribution (Vd) of propranolol was similarly unaffected by spinal anesthesia.

Whelan, E.; Wood, A.J.; Shay, S.; Wood, M. (Vanderbilt Univ. School of Medicine, Nashville, TN (USA))

1989-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile  

SciTech Connect (OSTI)

The plant alkaloid ibogaine has promising anti-addictive properties. Albeit not licenced as a therapeutic drug, and despite hints that ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Na{sub v}1.5 sodium and Ca{sub v}1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (? 10 ?M) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias. - Highlights: We study effects of anti-addiction drug ibogaine on ionic currents in cardiomyocytes. We assess the cardiac ion channel profile of ibogaine. Ibogaine inhibits hERG potassium, sodium and calcium channels. Ibogaines effects on ion channels are a potential source of cardiac arrhythmias. 18-Methoxycoronaridine has a lower affinity for cardiac ion channels than ibogaine.

Koenig, Xaver; Kovar, Michael; Rubi, Lena; Mike, Agnes K.; Lukacs, Peter; Gawali, Vaibhavkumar S.; Todt, Hannes [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Hilber, Karlheinz, E-mail: karlheinz.hilber@meduniwien.ac.at [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Sandtner, Walter [Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna (Austria)

2013-12-01T23:59:59.000Z

442

E-Print Network 3.0 - anti-cancer drug infusion Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

infusion Search Powered by Explorit Topic List Advanced Search Sample search results for: anti-cancer drug infusion Page: << < 1 2 3 4 5 > >> 1 Friday, April 29, 2011 UNM Research...

443

Thermo-responsive Layer-by-Layer Assemblies for Nanoparticle-based Drug Delivery  

E-Print Network [OSTI]

release in response to temperature is still challenging. Here, a thermo-responsive drug delivery system of solid dexamethasone nanoparticles (DXM NPs) encapsulated in a model LbL assembly of strong polyelectrolytes poly (diallyldimethylammonium chloride...

Zhou, Jing

2013-11-26T23:59:59.000Z

444

Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating  

E-Print Network [OSTI]

Electrically triggered drug delivery represents an attractive option for actively and remotely controlling the release of a therapeutic from an implantable device (e.g., a pharmacy-on-a-chip). Here we report the fabrication ...

Schmidt, Daniel J.

445

Emergency delivery of Vasopressin from an implantable MEMS rapid drug delivery device  

E-Print Network [OSTI]

An implantable rapid drug delivery device based on micro-electro-mechanical systems (MEMS) technology was designed, fabricated and validated for the in vivo rapid delivery of vasopressin in a rabbit model. In vitro ...

Ho Duc, Hong Linh, 1978-

2009-01-01T23:59:59.000Z

446

E-Print Network 3.0 - arthritis drugs advisory Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: arthritis drugs advisory Page: << < 1 2 3 4 5 > >> 1 CURRICULUM VITAE DANIEL J. McCARTY, M.D. Summary: Diseases Consultant to the Surgeon General USPHS...

447

E-Print Network 3.0 - antimalarial drug quality Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to set logical priorities in anti-malarial drug discovery initiatives Ian C Boulton1, Solomon Nwaka2, Ian... A Ward*9 Abstract Despite increasing efforts and support for...

448

E-Print Network 3.0 - antimalarial drugs disrupt Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to set logical priorities in anti-malarial drug discovery initiatives Ian C Boulton1, Solomon Nwaka2, Ian... A Ward*9 Abstract Despite increasing efforts and support for...

449

E-Print Network 3.0 - antimalarial drugs pakistan Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to set logical priorities in anti-malarial drug discovery initiatives Ian C Boulton1, Solomon Nwaka2, Ian... A Ward*9 Abstract Despite increasing efforts and support for...

450

Application of microfluidic emulsion technology to biochemistry, drug delivery and Lab-on-a-Chip programmability  

E-Print Network [OSTI]

This research applies microfluidic emulsion technology to three diverse problems; biochemistry, drug delivery and lab-on-a-chip programmability. These subjects represent distinct research programs, but the underlying physics ...

Urbanski, John Paul

2005-01-01T23:59:59.000Z

451

E-Print Network 3.0 - anti-cancer drug works Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

has its own shape or color. This does not affect how it works. For example, Cipro... as a brand name drug: It works the same way in the body It is as safe. It has the same use. It...

452

Japan and Taiwan in the wake of bio-globalization : drugs, race and standards  

E-Print Network [OSTI]

This is a study of Japan and Taiwan's different responses to the expansion of the global drug industry. The thesis focuses on the problematic of "voicing," of how a state can make its interests heard in the International ...

Kuo, Wen-Hua

2005-01-01T23:59:59.000Z

453

Development of a collagen gel sandwich hepatocyte bioreactor for detecting hepatotoxicity of drugs and chemicals  

E-Print Network [OSTI]

Understanding the hepatotoxicity of drugs and chemicals is essential for progress in academic research, medical science and in the development of new pharmaceuticals. Studying hepatotoxicity in vitro is a challenging task ...

Farkas, Dra, 1976-

2004-01-01T23:59:59.000Z

454

Structural and functional consequences of platinum anticancer drug binding to free and nucleosomal DNA  

E-Print Network [OSTI]

Cisplatin, carboplatin, and oxaliplatin are three FDA-approved members of the platinum anticancer drug family. These compounds induce apoptosis in tumor cells by binding to nuclear DNA, forming a variety of adducts, and ...

Todd, Ryan Christopher, 1981-

2010-01-01T23:59:59.000Z

455

Efflux of drugs and solutes from brain: the interactive roles of diffusional transcapillary  

E-Print Network [OSTI]

anesthesia (24 h) than with no anesthesia or ketaminexylazine anesthesia (2 to 3 h). These results show by anesthesia, and suggests that convection-mediated efflux may be manipulated to increase or decrease drug

Lipton, Howard L.

456

Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium tuberculosis  

E-Print Network [OSTI]

infection. High Throughput Screening can be used to both find and analyze promising drug candidates. Using automation, thousands of compounds can be tested against an attenuated strain of Tuberculosis and separate the promising compounds from the ineffective...

LaiHing, Steven 1983-

2011-07-27T23:59:59.000Z

457

The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier  

E-Print Network [OSTI]

It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells. An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is ...

Wang, Jing

2008-01-01T23:59:59.000Z

458

Nanoparticle-based combination therapy toward overcoming drug resistance in cancer  

E-Print Network [OSTI]

Review Nanoparticle-based combination therapy toward overcoming drug resistance in cancer Che-Ming Jack Hu, Liangfang Zhang * Department of Nanoengineering and Moores Cancer Center, University . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1106 3. Combinatorial nanoparticles against multidrug resistance in cancer

Zhang, Liangfang

459

Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device  

E-Print Network [OSTI]

The goal of this thesis was to advance an implantable drug delivery MEMS (MicroElectroMechanical Systems) device developed in our laboratory. This device was designed to locally deliver multiple substances in complex release ...

Li, Yawen, 1972-

2005-01-01T23:59:59.000Z

460

E-Print Network 3.0 - antimotion sickness drugs Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the Graduate Assistants & Pre-Doc Fellows of Summary: Paid as any other Sickness Elective Abortion No Benefits No Benefits AlcoholismDrug Abuse, 31 days... and sickness policy...

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Pricing and reimbursement challenges for fixed dose combination cardiovascular drugs and intravenous oncologies  

E-Print Network [OSTI]

Over the past ten years there has been increasing public concern regarding the rising costs of pharmaceuticals. Drug expenditure is the fastest growing sector of healthcare costs in the United States. The structure of the ...

Cronin-Fine, Drew

2012-01-01T23:59:59.000Z

462

The role of drug-associated cues on the maintenance of cocaine self-administration  

E-Print Network [OSTI]

THE ROLE OF DRUG-ASSOCIATED CUES ON THE MAINTENANCE OF COCAINE SELF-ADMINISTRATION A Thesis by BRIAN CHRISTOPHER PARTRIDGE Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 2000 Major Subject: Psychology THE ROLE OF DRUG-ASSOCIATED CUES ON THE MAINTENANCE OF COCAINE SELF-ADMINISTRATION A Thesis by BRIAN CHRISTOPHER PARTRIDGE Submitted to the Office of Graduate Studies of Texas A...

Partridge, Brian Christopher

2012-06-07T23:59:59.000Z

463

Counterion Effects on Nano-confined Metal-Drug-DNA Complexes  

E-Print Network [OSTI]

We have explored morphology of DNA molecules bound with Cu-complexes of piroxicam molecules, a non-steroidal anti-inflammatory drug (NSAID), under one-dimensional confinement of thin films and have studied the effect of counterions present in a buffer. X-ray reflectivity at and away from the Cu K absorption edge and atomic force microscopy studies reveal that confinement segregates the drug molecules preferentially in a top layer of the DNA film, and counterions enhance this segregation.

Nupur Biswas; Sreeja Chakraborty; Alokmay Datta; Munna Sarkar; Mrinmay K. Mukhopadhyay; Mrinal K. Bera; Hideki Seto

2014-04-05T23:59:59.000Z

464

Upscaling solute transport in naturally fractured porous media with the continuous time random walk method  

SciTech Connect (OSTI)

Solute transport in fractured porous media is typically 'non-Fickian'; that is, it is characterized by early breakthrough and long tailing and by nonlinear growth of the Green function-centered second moment. This behavior is due to the effects of (1) multirate diffusion occurring between the highly permeable fracture network and the low-permeability rock matrix, (2) a wide range of advection rates in the fractures and, possibly, the matrix as well, and (3) a range of path lengths. As a consequence, prediction of solute transport processes at the macroscale represents a formidable challenge. Classical dual-porosity (or mobile-immobile) approaches in conjunction with an advection-dispersion equation and macroscopic dispersivity commonly fail to predict breakthrough of fractured porous media accurately. It was recently demonstrated that the continuous time random walk (CTRW) method can be used as a generalized upscaling approach. Here we extend this work and use results from high-resolution finite element-finite volume-based simulations of solute transport in an outcrop analogue of a naturally fractured reservoir to calibrate the CTRW method by extracting a distribution of retention times. This procedure allows us to predict breakthrough at other model locations accurately and to gain significant insight into the nature of the fracture-matrix interaction in naturally fractured porous reservoirs with geologically realistic fracture geometries.

Geiger, S.; Cortis, A.; Birkholzer, J.T.

2010-04-01T23:59:59.000Z

465

Time Valid One-Time Signature for Time-Critical Multicast Data Authentication  

E-Print Network [OSTI]

malicious attacks. In this paper, we propose a novel signature model ­ Time Valid One-Time Signature (TV perfect tolerance to packet loss and strong robustness against malicious attacks. The communication is found in current substation communication systems where critical messages related to transient faults (e

Nahrstedt, Klara

466

Contacts of space--times  

SciTech Connect (OSTI)

The concept of contact between manifolds is applied to space--times of general relativity. For a given background space--time a contact approximation of second order is defined and interpreted both from the point of view of a metric pertubation and of a higher order tangent manifold. In the first case, an application to the high frequency gravitational wave hypothesis is suggested. In the second case, a constant curvature tangent bundle is constructed and suggested as a means to define a ten parameter local space--time symmetry.

Maia, M.D.

1981-03-01T23:59:59.000Z

467

Dose critical in-vivo detection of anti-cancer drug levels in blood  

DOE Patents [OSTI]

A method and apparatus are disclosed for the in vivo and in vitro detection and measurement of dose critical levels of DNA-binding anti-cancer drug levels in biological fluids. The apparatus comprises a laser based fiber optic sensor (optrode) which utilizes the secondary interactions between the drug and an intercalating fluorochrome bound to a probe DNA, which in turn is attached to the fiber tip at one end thereof. The other end of the optical fiber is attached to an illumination source, detector and recorder. The fluorescence intensity is measured as a function of the drug concentration and its binding constant to the probe DNA. Anticancer drugs which lend themselves to analysis by the use of the method and the optrode of the present invention include doxorubicin, daunorubicin, carminomycin, aclacinomycin, chlorambucil, cyclophosphamide, methotrexate, 5-uracil, arabinosyl cytosine, mitomycin, cis-platinum 11 diamine dichloride procarbazine, vinblastine vincristine and the like. The present method and device are suitable for the continuous monitoring of the levels of these and other anticancer drugs in biological fluids such as blood, serum, urine and the like. The optrode of the instant invention also enables the measurement of the levels of these drugs from a remote location and from multiple samples.

Miller, Holly H. (Bethel Island, CA); Hirschfeld, deceased, Tomas B. (late of Livermore, CA)

1991-01-01T23:59:59.000Z

468

Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion  

SciTech Connect (OSTI)

Ketamine is widely used as an anesthetic in a variety of drug combinations in human and veterinary medicine. Recently, it gained new interest for use in long-term pain therapy administered in sub-anesthetic doses in humans and animals. The purpose of this study was to develop a physiologically based pharmacokinetic (PBPk) model for ketamine in ponies and to investigate the effect of low-dose ketamine infusion on the amplitude and the duration of the nociceptive withdrawal reflex (NWR). A target-controlled infusion (TCI) of ketamine with a target plasma level of 1 {mu}g/ml S-ketamine over 120 min under isoflurane anesthesia was performed in Shetland ponies. A quantitative electromyographic assessment of the NWR was done before, during and after the TCI. Plasma levels of R-/S-ketamine and R-/S-norketamine were determined by enantioselective capillary electrophoresis. These data and two additional data sets from bolus studies were used to build a PBPk model for ketamine in ponies. The peak-to-peak amplitude and the duration of the NWR decreased significantly during TCI and returned slowly toward baseline values after the end of TCI. The PBPk model provides reliable prediction of plasma and tissue levels of R- and S-ketamine and R- and S-norketamine. Furthermore, biotransformation of ketamine takes place in the liver and in the lung via first-pass metabolism. Plasma concentrations of S-norketamine were higher compared to R-norketamine during TCI at all time points. Analysis of the data suggested identical biotransformation rates from the parent compounds to the principle metabolites (R- and S-norketamine) but different downstream metabolism to further metabolites. The PBPk model can provide predictions of R- and S-ketamine and norketamine concentrations in other clinical settings (e.g. horses)

Knobloch, M. [Division Veterinary Pharmacology and Toxicology, University of Bern, 3012 Bern (Switzerland); Portier, C.J. [Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 (United States); Levionnois, O.L. [Division Anesthesiology, Department of Clinical Veterinary Medicine, University of Bern 3012, Bern (Switzerland); Theurillat, R. [Department of Clinical Pharmacology, University of Bern, 3010 Bern (Switzerland); Thormann, W. [Department of Clinical Pharmacology, University of Bern, 3010 Bern (Switzerland); Spadavecchia, C. [Division Anesthesiology, Department of Clinical Veterinary Medicine, University of Bern 3012, Bern (Switzerland); Mevissen, M. [Division Veterinary Pharmacology and Toxicology, University of Bern, 3012 Bern (Switzerland)]. E-mail: meike.mevissen@vpi.unibe.ch

2006-11-01T23:59:59.000Z

469

Time Machine at the LHC  

E-Print Network [OSTI]

Recently, black hole and brane production at CERN's Large Hadron Collider (LHC) has been widely discussed. We suggest that there is a possibility to test causality at the LHC. We argue that if the scale of quantum gravity is of the order of few TeVs, proton-proton collisions at the LHC could lead to the formation of time machines (spacetime regions with closed timelike curves) which violate causality. One model for the time machine is a traversable wormhole. We argue that the traversable wormhole production cross section at the LHC is of the same order as the cross section for the black hole production. Traversable wormholes assume violation of the null energy condition (NEC) and an exotic matter similar to the dark energy is required. Decay of the wormholes/time machines and signatures of time machine events at the LHC are discussed.

I. Ya. Aref'eva; I. V. Volovich

2007-10-15T23:59:59.000Z

470

TIME-DEPENDENT MAXWELL'S EQUATIONS*  

E-Print Network [OSTI]

Department of Mathematical Sciences, University of Delaware, Newark, Delaware 19716. (monklath.udel. ... The plan of the paperis as follows. In 2 we .... which states that the energy in the discrete system is independent of time. This energy...

471

Jaguar/Kraken time lapse  

SciTech Connect (OSTI)

Time lapse video of the upgrade to ORNL's Jaguar and the University of Tennessee's Kraken, the world's fastest and third-fastest supercomputers. For more information, please visit www.nccs.gov.

2009-11-17T23:59:59.000Z

472

Reduction in maximum time uncertainty of paired time signals  

DOE Patents [OSTI]

Reduction in the maximum time uncertainty (t/sub max/ - t/sub min/) of a series of paired time signals t/sub 1/ and t/sub 2/ varying between two input terminals and representative of a series of single events where t/sub 1/ less than or equal to t/sub 2/ and t/sub 1/ + t/sub 2/ equals a constant, is carried out with a circuit utilizing a combination of OR and AND gates as signal selecting means and one or more time delays to increase the minimum value (t/sub min/) of the first signal t/sub 1/ closer to t/sub max/ and thereby reduce the difference. The circuit may utilize a plurality of stages to reduce the uncertainty by factors of 20 to 800.

Theodosiou, G.E.; Dawson, J.W.

1981-02-11T23:59:59.000Z

473

Pharmacokinetics, or "How a drug reaches its target"  

E-Print Network [OSTI]

15 20 25 30 35 40 45 Time (days) Concentration(mg·L-1) InL Michaelis-Menten(L) Cld CP, VcCt, Vt koff ke(RL) InL L = Ligand R = receptor RL = Receptor-Ligand complex ke(L) Parameter fit for data set 2 The dynamics is given by the system of nonlinear differential equations: dL dt = InL - konL · R + koff

Gugat, Martin

474

UNDERGRAD FULL-TIME PART-TIME UNDERGRAD FULL-TIME PART-TIME Arts & Social Sciences 4706 1118 15 -19 3910 0  

E-Print Network [OSTI]

-TIME UNDERGRAD FULL-TIME PART-TIME Year 1 3431 432 Tri-County area 7533 1474 Year 2 3012 406 Rest of Ontario 2929 GRADUATE FULL-TIME PART-TIME GRADUATE FULL-TIME PART-TIME Tri-County area 586 80 Spec & Cert 3 2 Rest

475

The Broken Symmetry of Time  

SciTech Connect (OSTI)

This paper seeks to clarify features of time asymmetry in terms of symmetry breaking. It is observed that, in general, a contingent situation or event requires the breaking of an underlying symmetry. The distinction between the universal anisotropy of temporal processes and the irreversibility of certain physical processes is clarified. It is also proposed that the Transactional Interpretation of quantum mechanics offers an effective way to explain general thermodynamic asymmetry in terms of the time asymmetry of radiation, where prior such efforts have fallen short.

Kastner, Ruth E. [Department of Philosophy, University of Maryland, College Park, MD 20742 (United States)

2011-11-29T23:59:59.000Z

476

Noncommutative space-time models  

E-Print Network [OSTI]

The FRT quantum Euclidean spaces $O_q^N$ are formulated in terms of Cartesian generators. The quantum analogs of N-dimensional Cayley-Klein spaces are obtained by contractions and analytical continuations. Noncommutative constant curvature spaces are introduced as a spheres in the quantum Cayley-Klein spaces. For N=5 part of them are interpreted as the noncommutative analogs of (1+3) space-time models. As a result the quantum (anti) de Sitter, Newton, Galilei kinematics with the fundamental length and the fundamental time are suggested.

N. A. Gromov; V. V. Kuratov

2005-07-01T23:59:59.000Z

477

Quantum mechanical approaches to in silico enzyme characterization and drug design  

SciTech Connect (OSTI)

The astonishing, exponentially increasing rates of genome sequencing has led to one of the most significant challenges for the biological and computational sciences in the 21st century: assigning the likely functions of the encoded proteins. Enzymes represent a particular challenge, and a critical one, because the universe of enzymes is likely to contain many novel functions that may be useful for synthetic biology, or as drug targets. Current approaches to protein annotation are largely based on bioinformatics. At the simplest level, this annotation involves transferring the annotations of characterized enzymes to related sequences. In practice, however, there is no simple, sequence based criterion for transferring annotations, and bioinformatics alone cannot propose new enzymatic functions. Structure-based computational methods have the potential to address these limitations, by identifying potential substrates of enzymes, as we and others have shown. One successful approach has used in silico 'docking' methods, more commonly applied in structure-based drug design, to identify possible metabolite substrates. A major limitation of this approach is that it only considers substrate binding, and does not directly assess the potential of the enzyme to catalyze a particular reaction using a particular substrate. That is, substrate binding affinity is necessary but not sufficient to assign function. A reaction profile is ultimately what is needed for a more complete quantitative description of function. To address this rather fundamental limitation, they propose to use quantum mechanical methods to explicitly compute transition state barriers that govern the rates of catalysis. Although quantum mechanical, and mixed quantum/classical (QM/MM), methods have been used extensively to investigate enzymatic reactions, the focus has been primarily on elucidating complex reaction mechanisms. Here, the key catalytic steps are known, and they use these methods quantify substrate specificity. That is, we bring the power of quantum mechanics to bear on the problem of annotating enzyme function, which is a novel approach. Although it has been clear to us at the Jacobson group for some time that enzyme specificity may be encoded in transition states, rather than simply substrate recognition, the main limitation has always been computational expense. Using a hierarchy of different methods, they can reduce the list of plausible substrates of an enzyme to a small number in most cases, but even identifying the transition states for a dozen plausible substrates requires significant computational effort, beyond what is practical using standard QM/MM methods. For this project, they have chosen two enzyme superfamilies which they have used as 'model systems' for functional assignment. The enolase superfamily is a large group of {alpha}-{beta} barrel enzymes with highly diverse substrates and chemical transformations. Despite decades of work, over a third of the superfamily remains unassigned, which means that the remaining cases are by definition difficult to assign. They have focused on acid sugar dehydratases, and have considerable expertise on the matter. They are also interested in the isoprenoid synthase superfamily, which is of central interest to the synthetic biology community, because these enzymes are used by nature to create complex rare natural products of medicinal value. the most notable example of this is the artemisinin, an antimalarial compound that is found in trace amounts in the wormwod root. From the standpoint of enzyme function assignment, these enzymes are intriguing because they use a small number of chemically simple substrates to generate, potentially, tens of thousands of different products. Hence, substrate binding specificity is only a small part of the challenge; the key is determining how the enzyme directs the carbocation chemistry to specific products. These more complex modeling approaches clearly require quantum mechanical methods.

Nilmeier, J P; Fattebert, J L; Jacobson, M P; Kalyanaraman, C

2012-01-17T23:59:59.000Z

478

Food and drug reward: overlapping circuits in human obesity and addiction  

SciTech Connect (OSTI)

Both drug addiction and obesity can be defined as disorders in which the saliency value of one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to, and at the expense of others. This model is consistent with the fact that both drugs and food have powerful reinforcing effects - partly mediated by dopamine increases in the limbic system - that, under certain circumstances or in vulnerable individuals, could overwhelm the brain's homeostatic control mechanisms. Such parallels have generated significant interest in understanding the shared vulnerabilities and trajectories between addiction and obesity. Now, brain imaging discoveries have started to uncover common features between these two conditions and to delineate some of the overlapping brain circuits whose dysfunctions may explain stereotypic and related behavioral deficits in human subjects. These results suggest that both obese and drug addicted individuals suffer from impairments in dopaminergic pathways that regulate neuronal systems associated not only with reward sensitivity and incentive motivation, but also with conditioning (memory/learning), impulse control (behavioral inhibition), stress reactivity and interoceptive awareness. Here, we integrate findings predominantly derived from positron emission tomography that investigate the role of dopamine in drug addiction and in obesity and propose an updated working model to help identify treatment strategies that may benefit both of these conditions.

Volkow N. D.; Wang G.; Volkow, N.D.; Wang, G.-J.; Fowler, J.S.; Tomasi, D.; Baler, R.

2012-12-01T23:59:59.000Z

479

Time, Humans and Societal Challenges  

E-Print Network [OSTI]

.y. Oldest fossil (Australia): 3.5 b.y Oldest rock (gneiss; Slave, N. Canada): 3.96 b.y Oldest mineral, so most growth there. Less-developed regions comprised 30% of global population in 1900, 80% in 2000,000 calories per day Estimated that raising US child consumes 15-20 times resources used in raising child

480

Last Time... on the website  

E-Print Network [OSTI]

will block until the command finishes netscape & #12;Complex Commands · The shell's power is in its abilityLast Time... on the website #12;Lecture 6 Shell Scripting #12;What is a shell? · The user interface programming language · A program like any other ­ This is why there are so many shells #12;Shell History

Mohri, Mehryar

Note: This page contains sample records for the topic "drug retention times" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Waste to Energy Time Activities  

E-Print Network [OSTI]

SEMINAR Waste to Energy Time Activities 9:30-9:40 Brief introduction of participants 9:40-10:10 Presentation of Dr. Kalogirou, "Waste to Energy: An Integral Part of Worldwide Sustainable Waste Management" 10. Sofia Bethanis, "Production of synthetic aggregates for use in structural concrete from waste to energy

482

The TESLA Time Projection Chamber  

E-Print Network [OSTI]

A large Time Projection Chamber is proposed as part of the tracking system for a detector at the TESLA electron positron linear collider. Different ongoing R&D studies are reviewed, stressing progress made on a new type readout technique based on Micro-Pattern Gas Detectors.

Nabil Ghodbane

2002-12-12T23:59:59.000Z

483

TIME-RESOLVED VIBRATIONAL SPECTROSCOPY  

SciTech Connect (OSTI)

This document contains the Proceedings from the 14th International Conference on Time-Resolved Vibrational Spectroscopy, which was held in Meredith, NH from May 9-14, 2009. The study of molecular dynamics in chemical reaction and biological processes using time-resolved spectroscopy plays an important role in our understanding of energy conversion, storage, and utilization problems. Fundamental studies of chemical reactivity, molecular rearrangements, and charge transport are broadly supported by the DOEâ??s Office of Science because of their role in the development of alternative energy sources, the understanding of biological energy conversion processes, the efficient utilization of existing energy resources, and the mitigation of reactive intermediates in radiation chemistry. In addition, time-resolved spectroscopy is central to all five of DOEâ??s grand challenges for fundamental energy science. The Time-Resolved Vibrational Spectroscopy conference is organized biennially to bring the leaders in this field from around the globe together with young scientists to discuss the most recent scientific and technological advances. The latest technology in ultrafast infrared, Raman, and terahertz spectroscopy and the scientific advances that these methods enable were covered. Particular emphasis was placed on new experimental methods used to probe molecular dynamics in liquids, solids, interfaces, nanostructured materials, and biomolecules.

Andrei Tokmakoff, MIT (Conference Chair) [Conference Chair; Paul Champion, Northeastern University; Edwin J. Heilweil, NIST; Keith A. Nelson, MIT; Larry Ziegler, Boston University

2009-05-14T23:59:59.000Z

484

Curricular internship Timing and Duration  

E-Print Network [OSTI]

1 Art.1 Curricular internship Art.2 Objectives Art.3 Timing and Duration Art.4 Choice of Employer Art.5 Pertinence of the internship Art.6 Internship Search GRADUATE INTERNSHIP GUIDELINES Faculties training or work experience, herein referred to as `internship', is one of the graduation requirements. 2

Krause, Rolf

485

Time for State Bicycle Helmet  

E-Print Network [OSTI]

Time for State Bicycle Helmet Legislation? ?? Jon Roesler, MS Ayo Adeniyi, MBBS, MPH Mark Kinde is the most bike- friendly city in the U.S. in Y2010 #12;#12;Minneapolis is #1 Bike City Bicycling.com list? · Bicycle helmets reduce head injuries and deaths by up to 85%* · If each rider wore a helmet one death per

Minnesota, University of

486

Linking opioid-dependent hospital patients to drug treatment: Health care use and costs 6 months after randomization.  

E-Print Network [OSTI]

to substance abuse treatment, medical care, and socialmedical care and drug abuse treatment: utilization of on-Abuse Treatment Visits Outpatient Mental Health Care Visits

Barnett, Paul G; Masson, Carmen L; Sorensen, James L; Wong, Wynnie; Hall, Sharon

2006-01-01T23:59:59.000Z

487

Regulatory approval of cancer risk-reducing (chemopreventive) drugs: moving what we have learned into the clinic.  

E-Print Network [OSTI]

should incentivize pharmaceutical industry investment inapproval by the pharmaceutical industry. The history ofReduction The pharmaceutical industry views drug development

2011-01-01T23:59:59.000Z

488

High resolution time interval meter  

DOE Patents [OSTI]

Method and apparatus are provided for measuring the time interval between two events to a higher resolution than reliability available from conventional circuits and component. An internal clock pulse is provided at a frequency compatible with conventional component operating frequencies for reliable operation. Lumped constant delay circuits are provided for generating outputs at delay intervals corresponding to the desired high resolution. An initiation START pulse is input to generate first high resolution data. A termination STOP pulse is input to generate second high resolution data. Internal counters count at the low frequency internal clock pulse rate between the START and STOP pulses. The first and second high resolution data are logically combined to directly provide high resolution data to one counter and correct the count in the low resolution counter to obtain a high resolution time interval measurement.

Martin, A.D.

1986-05-09T23:59:59.000Z

489

Quantitative evaluation of the effect of p-glycoprotein on oral drug absorption  

E-Print Network [OSTI]

Concentration P-gp Expression Level Affinity to P-gp Passive Membrane Permeability Cellular Accumulation Transport Experiments by using P-gp Expressing Cell Monolayers Apical Basal Caco-2 cell? MDR1-MDCK cell ? Permeability ratio Transport Rate = f ( Km, Vmax..., Ppassive ) ?Impact of P-gp on in vivo Oral Drug Absorption? Development of kinetic model that can predict the in vivo absorption of P-glycoprotein substrate drugs from in vitro data. PURPOSE 0 1.0 2.0 3.0 P e r m e a b i l i t y r a t i o ( B L t o A P...

Shirasaka, Yoshiyuki

2006-10-27T23:59:59.000Z

490

Introduction Space Time Codes Space Time Coding with Feedback New Thoughts Summary Space-Time Coding for Multi-Antenna  

E-Print Network [OSTI]

Introduction Space Time Codes Space Time Coding with Feedback New Thoughts Summary Space 2007 #12;Introduction Space Time Codes Space Time Coding with Feedback New Thoughts Summary MIMO: Diversity vs Multiplexing Multiplexing Diversity Pictures taken from lectures notes on Space Time Coding

Veeravalli, Venugopal

491

A Comparison of Global and Local Search Methods in Drug Christopher D. Rosin  

E-Print Network [OSTI]

, and heuristic search is used to minimize this energy. Previous versions of Autodock used simulated annealingA Comparison of Global and Local Search Methods in Drug Docking Christopher D. Rosin CSE Dept., UCSD La Jolla, CA 92093 rik@cs.ucsd.edu Abstract Molecular docking software makes compu­ tational

Belew, Richard K.

492

OPERATING PROCEDURES TO IMPLEMENT THE COLLEGE OF CHARLESTON POLICY ON ALCOHOL AND ILLICIT DRUG TESTING  

E-Print Network [OSTI]

for developing the annual list of employee positions that will be subject to such testing. (a) Not later than May Positions. (b) The DER and the Director shall evaluate the lists provided to determine if each designated AND ILLICIT DRUG TESTING THE LANGUAGE USED IN THIS DOCUMENT DOES NOT CREATE AN EMPLOYMENT CONTRACT BETWEEN

Kasman, Alex

493

Raspberry derived mesoporous carbon-tubules and fixed-bed adsorption of pharmaceutical drugs  

E-Print Network [OSTI]

Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing (Innovation Centre for Safety and Material Technology, TUMA), 50130 Mikkeli, Finland d Soil and Water Science Department, University of Florida, Gainesville, FL 32611-0290, USA 1. Introduction Pharmaceutical drugs (PD

Ma, Lena

494

Universal Access to HIV Treatment versus Universal `Test and Treat': Transmission, Drug Resistance & Treatment  

E-Print Network [OSTI]

Universal Access to HIV Treatment versus Universal `Test and Treat': Transmission, Drug Resistance a universal `test and treat' (T&T) strategy to try to eliminate HIV in SA; treatment reduces infectivity in need or not. This would require treating 5 million individuals almost immediately and providing

Blower, Sally

495

Novel Approaches to Breast Cancer Therapy: Evaluation of Next Generation Dendrimers for Drug Delivery  

E-Print Network [OSTI]

laboratory has shown that treating the cancer cells with a novel dendrimer construct (G2-NH2) alone, without drug or DNA present, can be cytotoxic. The purpose of this study was to test the next generation of dendrimers for the ability to deliver DNA...

Snow, Merideth

2010-07-14T23:59:59.000Z

496

Comparison of Protein Active Site Structures for Functional Annotation of Proteins and Drug Design  

E-Print Network [OSTI]

of various genomics efforts has been a vast growth in putative protein sequences that lack any experimental there are numerous examples of proteins with similar folds that lack any significant sequence homology.8Comparison of Protein Active Site Structures for Functional Annotation of Proteins and Drug Design

Powers, Robert

497

Floating hot-melt extruded tablets for gastroretentive controlled drug release system  

E-Print Network [OSTI]

a gastric floating dosage form using the puff ability at the die of a twin-screw extruder. Wei et al. [21Floating hot-melt extruded tablets for gastroretentive controlled drug release system Mamoru Fukuda bicarbonate on the physicochemical properties of controlled release hot- melt extruded (HME) tablets

Peppas, Nicholas A.

498

The Current State of Drug Discovery and a Potential Role for NMR Metabolomics  

E-Print Network [OSTI]

, Nebraska 68588-0304, United States ABSTRACT: The pharmaceutical industry has significantly contributed of the pharmaceutical industry. This is a complex issue with many contributing factors resulting from the numerous with druglike characteristics. BENEFITS OF DRUG DISCOVERY Extending Life Expectancy. The pharmaceutical

Powers, Robert

499

The Arizona Poison and Drug Information Center's toll free line is  

E-Print Network [OSTI]

· Poisonous plants · Food poisoning · Pesticide information · Poisonings of animals · Workplace exposuresThe Arizona Poison and Drug Information Center's toll free line is always open. Call us if: · You think someone has been poisoned. · You have questions about any type of poison. · You want information

Arizona, University of

500

Mining Linguistic Cues for Query Expansion: Applications to Drug Interaction Search  

E-Print Network [OSTI]

Mining Linguistic Cues for Query Expansion: Applications to Drug Interaction Search Sheng Guo answers to this question, by mining the literature, are valuable for pharmaceuti- cal companies, both in designing combination therapies for complex diseases including cancers. We study this problem as one

Ramakrishnan, Naren