National Library of Energy BETA

Sample records for drug delivery systems

  1. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  2. Packaging for a drug delivery microelectromechanical system

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2005-01-01

    Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

  3. Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System 

    E-Print Network [OSTI]

    Yu, Xiao

    2012-07-16

    Hydrophobic drug paclitaxel nanoparticles (PAX NPs) and pH sensitive hydrogels were prepared in this study to build a colon targeting nanoparticle based drug delivery system for oral administration. Negative charged PAX NPs at the size of 110...

  4. Drug delivery systems based on sugar-macromolecule conjugates Benjamin G Davis* & Mark A Robinson

    E-Print Network [OSTI]

    Davis, Ben G.

    Drug delivery systems based on sugar-macromolecule conjugates Benjamin G Davis* & Mark A Robinson in Drug Discovery & Development 2002 5(2): 279-288 PharmaPress Ltd ISSN 1367-6733 The specificity-tuning of active drug delivery through their great ability to undergo site- specific modification

  5. An implantable device for localized drug delivery and sensing

    E-Print Network [OSTI]

    Daniel, Karen D

    2009-01-01

    There are many potential clinical applications for localized drug delivery and sensing systems, such as cancer, vaccinations, pain management, and hormone therapy. Localized drug delivery systems reduce the amount of drug ...

  6. Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs

    E-Print Network [OSTI]

    Stauber, Zachary Jason

    2012-01-01

    Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

  7. Amphiphilic linear-dendritic block copolymers for drug delivery

    E-Print Network [OSTI]

    Nguyen, Phuong, Ph. D. Massachusetts Institute of Technology

    2007-01-01

    Polymeric drug delivery systems have been widely used in the pharmaceutical industry. Such systems can solubilize and sequester hydrophobic drugs from degradation, thereby increasing circulation half-life and efficacy. ...

  8. Emergency delivery of Vasopressin from an implantable MEMS rapid drug delivery device

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2009-01-01

    An implantable rapid drug delivery device based on micro-electro-mechanical systems (MEMS) technology was designed, fabricated and validated for the in vivo rapid delivery of vasopressin in a rabbit model. In vitro ...

  9. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  10. Mechanical loading impacts intramuscular drug transport : impact on local drug delivery

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2008-01-01

    Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue ...

  11. Drug delivery Sustained Drug Release from Non-eroding Nanoporous

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Drug delivery Sustained Drug Release from Non-eroding Nanoporous Templates** Evin Gultepe, Dattatri drug, doxorubicin (Dox), from different non-eroding nanopor- ous coatings. Detailed studies of drug phosphate-buffered saline (PBS), which is commonly employed to simulate in vivo conditions for drug release

  12. Development of a Light Actuated Drug Delivery-on-Demand System

    E-Print Network [OSTI]

    Linsley, Chase Schilling

    2015-01-01

    polymer scaffolds, Biomaterials, 28 (2007) 1862-1870. [16]for siRNA delivery, Biomaterials, 35 (2014) [47] E. Deu,for protein delivery, Biomaterials, 33 (2012) 9157-9164. [

  13. An Implantable MEMS Drug Delivery Device for Rapid Delivery in Ambulatory Emergency Care

    E-Print Network [OSTI]

    Elman, Noel

    We introduce the first implantable drug delivery system based on MEMS (Micro-Electro-Mechanical-Systems) technology specifically designed as a platform for treatment in ambulatory emergency care. The device is named ...

  14. Needle-free drug delivery using shock wave techniques

    E-Print Network [OSTI]

    Pavlov, Atanas (Atanas Ivanov)

    2006-01-01

    A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

  15. A fully implantable intracochlear drug delivery device : development and characterization

    E-Print Network [OSTI]

    Swan, Erin Eileen Leary, 1976-

    2009-01-01

    In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

  16. Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

    E-Print Network [OSTI]

    Tong, Rong

    We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, ...

  17. Titanium MEMS Technology Development for Drug Delivery and Microfluidic Applications

    E-Print Network [OSTI]

    Khandan, Omid

    2015-01-01

    Etching of Bulk Titanium for MEMS Applications. ” Journal ofMeng. 2012. “An Implantable MEMS Micropump System for Drugand Ellis Meng. 2009. “A Passive MEMS Drug Delivery Pump for

  18. A Model pH Induced Drug-Delivery System Based on Poly(methacrylic acid) and its Interpolymer complex

    E-Print Network [OSTI]

    Murugan, K Durai; Natarajan, P

    2015-01-01

    The dynamics and structural aspects of polymethacrylic acid bound rhodamine-123 (PMAA-R123) and its interpolymer complex with poly(vinylpyrrolidone) were investigated and the results show that these complexes have potential for use as drug-delivery system under physiological conditions. The time resolved fluorescence anisotropy decay of PMAA-R123 at different pH exhibits an associated anisotropy decay behavior characteristic of two different environments experienced by the fluorophore and decays with one shorter and another longer lifetime components. The anisotropy decay retains normal bi-exponential behavior under neutral pH. Fluorescence correlation spectroscopic investigation reveals that the attached fluorophore undergoes hydrolysis under basic condition which results in the release of the fluorophore from the polymer backbone. Shrinkage in the hydrodynamic radius of PMAA is observed on addition of the complementary polymer PVP which is attributed to the formation compact solubilised nanoparticle like ag...

  19. Development of a Light Actuated Drug Delivery-on-Demand System

    E-Print Network [OSTI]

    Linsley, Chase Schilling

    2015-01-01

    Photochemical mechanisms of light- triggered release fromNanospheres for Near-Infrared Light-Triggered Drug Release,products by phenothiazine dyes and light, Photochemistry and

  20. Development of a Light Actuated Drug Delivery-on-Demand System

    E-Print Network [OSTI]

    Linsley, Chase Schilling

    2015-01-01

    C.M. Ofner, Crosslinked gelatin matrices: release of aof model drugs from 10% (w/v) gelatin reservoirs over 7 daysfrom 10% and 20 % (w/v) gelatin reservoirs over 7 days

  1. Section 21: Drug Discovery/Delivery Pharmacokinetic Considerations of Local Drug Delivery to the Inner Ear by

    E-Print Network [OSTI]

    Salt, Alec N.

    1 Section 21: Drug Discovery/Delivery Pharmacokinetic Considerations of Local Drug Delivery.Plontke@uni-tuebingen.de Although there is increasing interest in the local delivery of drugs to the inner ear by applying them to the round window (RW) membrane, most drug application protocols have been empirically- based. As a result

  2. Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes

    E-Print Network [OSTI]

    Chau, Ying

    2005-01-01

    We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

  3. Computational Modeling of an MRI Guided Drug Delivery System Based on Magnetic Nanoparticle Aggregations for the Navigation of Paramagnetic Nanocapsules

    E-Print Network [OSTI]

    N. K. Lampropoulos; E. G. Karvelas; I. E. Sarris

    2015-04-14

    A computational method for magnetically guided drug delivery is presented and the results are compared for the aggregation process of magnetic particles within a fluid environment. The model is developed for the simulation of the aggregation patterns of magnetic nanoparticles under the influence of MRI magnetic coils. A novel approach for the calculation of the drag coefficient of aggregates is presented. The comparison against experimental and numerical results from the literature is showed that the proposed method predicts well the aggregations in respect to their size and pattern dependance, on the concentration and the strength of the magnetic field, as well as their velocity when particles are driven through the fluid by magnetic gradients.

  4. Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery

    SciTech Connect (OSTI)

    Saha, Dipendu [ORNL] [ORNL; Warren, Kaitlyn E [ORNL] [ORNL; Naskar, Amit K [ORNL] [ORNL

    2014-01-01

    Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

  5. One of the main issues with drug delivery is that drugs tend to disperse throughout the entire body, instead of targeting

    E-Print Network [OSTI]

    Metlushko, Vitali

    One of the main issues with drug delivery is that drugs tend to disperse throughout the entire body, instead of targeting the specific site (or area) that it is intended to reach. Therefore, drugs candidates for more focused drug delivery systems is magnetic manipulation of nanoparticles

  6. Design and Testing of an Impedance-Based Sensor for Monitoring Drug Delivery

    E-Print Network [OSTI]

    Sadoway, Donald Robert

    microelectromechanical systems MEMS device has been fabricated and tested. The sensor consists of two electrodesDesign and Testing of an Impedance-Based Sensor for Monitoring Drug Delivery Audrey M. Johnson, Massachusetts 02139, USA A new impedance-based sensor to monitor drug delivery from an implantable

  7. Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery

    E-Print Network [OSTI]

    Seto, Jennifer Elizabeth

    2011-01-01

    Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to ...

  8. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

    E-Print Network [OSTI]

    Carlyle, Wenda C.

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

  9. Thermo-responsive Layer-by-Layer Assemblies for Nanoparticle-based Drug Delivery 

    E-Print Network [OSTI]

    Zhou, Jing

    2013-11-26

    release in response to temperature is still challenging. Here, a thermo-responsive drug delivery system of solid dexamethasone nanoparticles (DXM NPs) encapsulated in a model LbL assembly of strong polyelectrolytes poly (diallyldimethylammonium chloride...

  10. Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device

    E-Print Network [OSTI]

    Li, Yawen, 1972-

    2005-01-01

    The goal of this thesis was to advance an implantable drug delivery MEMS (MicroElectroMechanical Systems) device developed in our laboratory. This device was designed to locally deliver multiple substances in complex release ...

  11. Secondary fuel delivery system

    DOE Patents [OSTI]

    Parker, David M. (Oviedo, FL); Cai, Weidong (Oviedo, FL); Garan, Daniel W. (Orlando, FL); Harris, Arthur J. (Orlando, FL)

    2010-02-23

    A secondary fuel delivery system for delivering a secondary stream of fuel and/or diluent to a secondary combustion zone located in the transition piece of a combustion engine, downstream of the engine primary combustion region is disclosed. The system includes a manifold formed integral to, and surrounding a portion of, the transition piece, a manifold inlet port, and a collection of injection nozzles. A flowsleeve augments fuel/diluent flow velocity and improves the system cooling effectiveness. Passive cooling elements, including effusion cooling holes located within the transition boundary and thermal-stress-dissipating gaps that resist thermal stress accumulation, provide supplemental heat dissipation in key areas. The system delivers a secondary fuel/diluent mixture to a secondary combustion zone located along the length of the transition piece, while reducing the impact of elevated vibration levels found within the transition piece and avoiding the heat dissipation difficulties often associated with traditional vibration reduction methods.

  12. An approach to drug delivery using novel carbohydrates to carry drugs

    E-Print Network [OSTI]

    Davis, Ben G.

    An approach to drug delivery using novel carbohydrates to carry drugs has recently been described of the cancer drug doxorubicin targeted to hepatocytes in a mouse liver tumour model. Known as the LEAPT step involves administering the rhamnose-capped pro-drug; the drug is activated in the target cell once

  13. Use of physical enhancers for gastrointestinal and transdermal drug delivery

    E-Print Network [OSTI]

    Schoelihammer, Carl M. (Carl Magnus)

    2015-01-01

    The research presented in this thesis represents a significant advance in the field of transdermal- and gastrointestinal (GI)-based drug delivery. With regards to the former, previous work has led to a thorough mechanistic ...

  14. Noninvasive quantification of drug delivery from an implantable MEMS device

    E-Print Network [OSTI]

    Johnson, Audrey M., 1976-

    2005-01-01

    (cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

  15. BIOENGINEERING, FOOD, AND NATURAL PRODUCTS Advances in Biomaterials, Drug Delivery, and

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    BIOENGINEERING, FOOD, AND NATURAL PRODUCTS Advances in Biomaterials, Drug Delivery, The University of Texas at Austin, Austin, TX, 78712 Biomaterials are widely used in numerous medical as biomateri- als, materials and approaches used in drug and protein deli®ery systems, materials used

  16. Fluid delivery control system

    DOE Patents [OSTI]

    Hoff, Brian D.; Johnson, Kris William; Algrain, Marcelo C.; Akasam, Sivaprasad

    2006-06-06

    A method of controlling the delivery of fluid to an engine includes receiving a fuel flow rate signal. An electric pump is arranged to deliver fluid to the engine. The speed of the electric pump is controlled based on the fuel flow rate signal.

  17. Controlling drug delivery across the placenta: A commentary

    E-Print Network [OSTI]

    Audus, Kenneth L.

    1999-01-01

    Audus, K.L. (1999) Controlling drug delivery across the placenta: A commentary. Eur. J. Pharm. Sci. 8, 161-165. PMID: 10379038. Publisher’s official version: http://dx.doi.org/10.1016/S0928-0987(99)00031-7. Open Access version: http... document contains the author’s accepted manuscript. For the publisher’s version, see the link in the header of this document.] Paper citation: Audus, K.L. (1999) Controlling drug delivery across the placenta: A commentary. Eur. J. Pharm. Sci. 8...

  18. Computational model of local intravascular drug delivery

    E-Print Network [OSTI]

    Balakrishnan, Brinda

    2007-01-01

    Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

  19. Transdermal drug delivery by localized intervention

    E-Print Network [OSTI]

    Weaver, James C.

    Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

  20. Diffusion-limited binding explains binary dose response for local arterial and tumour drug delivery

    E-Print Network [OSTI]

    Tzafriri, A. R.

    Background:? Local drug delivery has transformed medicine, yet it remains unclear how drug efficacy depends on physicochemical properties and delivery kinetics. Most therapies seek to prolong release, yet recent studies ...

  1. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance

    E-Print Network [OSTI]

    Clairambault, Jean

    period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

  2. MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells

    E-Print Network [OSTI]

    Gao, Jinming

    MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells Jagadeesh Setti micelle (MFM) system that is encoded with a lung cancer-targeting peptide (LCP), and encapsulated. The LCP-encoded MFM showed significantly increased Rv 6-dependent cell targeting in H2009 lung cancer

  3. DRUG DELIVERY IN BIOLOGICAL TISSUES: AN APPLICATION TO THE ELUTING STENT

    E-Print Network [OSTI]

    Pontrelli, Giuseppe

    DRUG DELIVERY IN BIOLOGICAL TISSUES: AN APPLICATION TO THE ELUTING STENT G. Pontrelli1 , F. de Monte2 , M. Prosi3 1. ABSTRACT The drug diffusion process through an arterial eluting stent is studied and a quantitative description for drug transport to evaluate feasibility of new drug delivery strategies

  4. Synthetic LDL as targeted drug delivery vehicle

    DOE Patents [OSTI]

    Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

    2012-08-28

    The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

  5. Commercial potential for thermal & magnetic sensitive polymer in drug delivery applications

    E-Print Network [OSTI]

    Edward, Jonathan M. (Jonathan Mark)

    2008-01-01

    Thermal and magnetically sensitive polymers are a new class of materials with unique properties suitable for applications in drug delivery. Specifically, these polymers can be combined with a drug reservoir to make a drug ...

  6. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Environmental Management (EM)

    Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -...

  7. Roadmap to Achieve Energy Delivery Systems Cybersecurity

    Broader source: Energy.gov (indexed) [DOE]

    to Achieve Energy Delivery Systems Cybersecurity ii Acknowledgements The Energy Sector Control Systems Working Group (ESCSWG) developed this roadmap in support of the Electricity...

  8. Cybersecurity Procurement Language for Energy Delivery Systems

    Office of Environmental Management (EM)

    delivery system from multiple Suppliers. Maintaining appropriate cybersecurity in such a system may require additional language that ensures the secure integration of components,...

  9. In vivo activation and biocompatibility of a MEMS microreservoir drug delivery device

    E-Print Network [OSTI]

    Shawgo, Rebecca Scheidt, 1976-

    2004-01-01

    Temporal and spatial control over the delivery of therapeutic compounds is an important, fertile, and rapidly advancing field of study in medicine. This work describes the advancement of a new technology of drug delivery ...

  10. Towards engineering hormone-binding globulins as drug delivery agents

    E-Print Network [OSTI]

    Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

    2014-11-26

    (2014) Towards Engineering Hormone-Binding Globulins as Drug Delivery Agents. PLoS ONE 9(11): e113402. doi:10.1371/journal.pone. 0113402 Editor: Ashley M. Buckle, Monash University, Australia Received: June 10, 2014 Accepted: October 24, 2014 Published... stock solution was prepared by dissolving lyophilised cortisol (Sigma Aldrich) in 80% ethanol to make a 500 mM solution, which was then diluted with water to make solutions of 20, 40 and 80 mM, with water being used as a negative control. Aliquots...

  11. Energy Delivery Systems Cybersecurity | Department of Energy

    Energy Savers [EERE]

    the country. CEDS program activities fall under five project areas, guided by the Roadmap to Achieve Energy Delivery Systems Cybersecurity. They are: Build a Culture of...

  12. The evaluation of melamine dendrimers as potential macromolecular vehicles for anticancer drug delivery 

    E-Print Network [OSTI]

    Neerman, Michael Frederick

    2005-08-29

    Often associated with chemotherapy are the dangerous and sometimes lifethreatening side effects towards non-cancerous tissue that can occur while on such drug regimens. The design and utilization of macromolecular drug delivery vehicles is gaining...

  13. Fiber coupled optical spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO)

    2008-08-12

    A spark delivery system for generating a spark using a laser beam is provided, the spark delivery system including a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. In addition, the laser delivery assembly includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. In accordance with embodiments of the present invention, the assembly may be used to create a spark in a combustion engine. In accordance with other embodiments of the present invention, a method of using the spark delivery system is provided. In addition, a method of choosing an appropriate fiber for creating a spark using a laser beam is also presented.

  14. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)

    1993-01-01

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  15. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  16. Fiber laser coupled optical spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

    2008-03-04

    A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

  17. Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 As part of the Obama Administration's goals to...

  18. Encapsulation of Pt(IV) prodrugs within a Pt(II) cage for drug delivery

    E-Print Network [OSTI]

    Suntharalingam, Kogularamanan

    This report presents a novel strategy that facilitates delivery of multiple, specific payloads of Pt(IV) prodrugs using a well-defined supramolecular system. This delivery system comprises a hexanuclear Pt(II) cage that ...

  19. Fabrication of Metal/Oxide Nanostructures by Anodization Processes for Biosensor, Drug Delivery and Supercapacitor Applications 

    E-Print Network [OSTI]

    Chen, Po-Chun

    2014-01-13

    This dissertation proposed to initiate the research into the fabrication of metal/oxide nanostructures by anodization process for biosensor, drug delivery and supercapacitor applications by producing different nanostructures ...

  20. Application of microfluidic emulsion technology to biochemistry, drug delivery and Lab-on-a-Chip programmability

    E-Print Network [OSTI]

    Urbanski, John Paul

    2005-01-01

    This research applies microfluidic emulsion technology to three diverse problems; biochemistry, drug delivery and lab-on-a-chip programmability. These subjects represent distinct research programs, but the underlying physics ...

  1. Enhancing pharmaceutical formulations to improve efficacy and delivery of drug molecules

    E-Print Network [OSTI]

    Weight, Alisha K. (Alisha Kessel)

    2013-01-01

    Major impediments to the full utility of current and potential drugs include issues of resistance and delivery. To address these challenges, in this thesis two directions of research were pursued: (1) the use of multivalent ...

  2. Functionalized Zirconium Phosphate Nano Platelets - From Surface Design to Drug Delivery 

    E-Print Network [OSTI]

    Mukherjee, Atashi

    2014-05-30

    the intended target or compartment. This dissertation will focus on the analytical characterization of zirconium phosphate (ZrP) in both alpha and theta phases as a drug delivery matrix utilizing multiple unique and novel analytical techniques. In the first...

  3. Exploring Polymer and Liposomal Carriers for Optimized Drug Delivery

    E-Print Network [OSTI]

    Ferguson, Heidi M

    2012-01-01

    1459–1467. Fox, M. E. Dendritic polymers for the delivery ofiii Chapter 1: Introduction to Polymer and Liposome Drugbioavailability. Conclusions Polymers and liposomes can be

  4. Renewable energy delivery systems and methods

    DOE Patents [OSTI]

    Walker, Howard Andrew

    2013-12-10

    A system, method and/or apparatus for the delivery of energy at a site, at least a portion of the energy being delivered by at least one or more of a plurality of renewable energy technologies, the system and method including calculating the load required by the site for the period; calculating the amount of renewable energy for the period, including obtaining a capacity and a percentage of the period for the renewable energy to be delivered; comparing the total load to the renewable energy available; and, implementing one or both of additional and alternative renewable energy sources for delivery of energy to the site.

  5. Specific and general binding in arterial drug delivery

    E-Print Network [OSTI]

    Levin, Andrew D. (Andrew David), 1976-

    2005-01-01

    Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

  6. Toward a drug delivery coating for intraocular lenses

    E-Print Network [OSTI]

    Smith, Renée Chivon

    2010-01-01

    Layer-by-layer assembly has become a quintessential tool for the creation of versatile, dynamic nanostructured materials able to dictate cellular behavior through exquisite surface functionality and delivery of bioactive ...

  7. Waste Feed Delivery Transfer System Analysis

    SciTech Connect (OSTI)

    JULYK, L.J.

    2000-05-05

    This document provides a documented basis for the required design pressure rating and pump pressure capacity of the Hanford Site waste-transfer system in support of the waste feed delivery to the privatization contractor for vitrification. The scope of the analysis includes the 200 East Area double-shell tank waste transfer pipeline system and the associated transfer system pumps for a11 Phase 1B and Phase 2 waste transfers from AN, AP, AW, AY, and A2 Tank Farms.

  8. Hydrogels as Biomaterials: Infinite Possibilities in Bionanotechnology, Drug Delivery, Biological Recognition,Tissue Engineering, and Pure Scientific Fun!

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    Hydrogels as Biomaterials: Infinite Possibilities in Bionanotechnology, Drug Delivery, Biological Recognition,Tissue Engineering, and Pure Scientific Fun! Nicholas A Peppas Laboratories of Biomaterials,, Drug, hydrogels have been approved as biomaterials in a wide range of biomedical applications and devices

  9. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Energy Savers [EERE]

    Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry...

  10. Near-infrared-actuated devices for remotely controlled drug delivery

    E-Print Network [OSTI]

    Timko, Brian P.

    A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage ...

  11. Biocompatibility of an implantable ophthalmic drug delivery device

    E-Print Network [OSTI]

    Cohen, Sarah J. (Sarah Jennifer)

    2007-01-01

    Diseases of the posterior eye present clinicians with a treatment challenge mainly due to the region's inaccessible location. Several drugs, including those available for the treatment of exudative age-related macular ...

  12. Drug Delivery DOI: 10.1002/anie.200802260

    E-Print Network [OSTI]

    Zare, Richard N.

    ,[2] which were genetically engineered to universally express luciferase, provides a rapid readout of the body by using a modified b-actin promoter.[4] As the majority of luciferin is cleared from the body nanoparticle could be engineered to target different cells.[3,6] PLA is an Food and Drug Administration (FDA

  13. A Universal Level Converter Towards the Realization of Energy Efficient Implantable Drug Delivery

    E-Print Network [OSTI]

    Mohanty, Saraju P.

    A Universal Level Converter Towards the Realization of Energy Efficient Implantable Drug Delivery VLSI Design and CAD Laboratory (VDCL), University of North Texas, Denton, TX 76203, USA. 2 Electrical many side effects, such as reduction in battery life time, increase in operating tempera- ture

  14. IN-PLANE BANDPASS REGULATION CHECK VALVE IN HEAT-SHRINK PACKAGING FOR DRUG DELIVERY

    E-Print Network [OSTI]

    Meng, Ellis

    IN-PLANE BANDPASS REGULATION CHECK VALVE IN HEAT-SHRINK PACKAGING FOR DRUG DELIVERY R. Lo and E. Meng University of Southern California, Los Angeles, California, USA ABSTRACT The first check valve valve design and these results were confirmed experimentally. The valve regulates flow between 150

  15. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Broader source: Energy.gov (indexed) [DOE]

    Analysis Using VCSE Promoting Control System Reliability Cybersecurity for Energy Delivery Systems 2010 Peer Review DOEOE National SCADA Test Bed Fiscal Year 2009 Work Plan...

  16. Titanium MEMS Technology Development for Drug Delivery and Microfluidic Applications

    E-Print Network [OSTI]

    Khandan, Omid

    2015-01-01

    The use of microelectromechanical systems (MEMS) technologyof microelectromechanical systems (MEMS) technology hasMEMS technology have emerged, and include biomedical microelectromechanical

  17. Hydrogen Delivery Technologies and Systems- Pipeline Transmission of Hydrogen

    Broader source: Energy.gov [DOE]

    Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen. Design and operations standards and materials for hydrogen and natural gas pipelines.

  18. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Energy Savers [EERE]

    Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the...

  19. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Environmental Management (EM)

    Review Presentations - Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the Power Grid (TCIPG)...

  20. Patch and Update Management Program for Energy Delivery Systems

    Office of Environmental Management (EM)

    a comprehensive solution to meet energy sector patch and update needs. A collaborative web portal aggregates and organizes patch and update information for energy delivery system...

  1. Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient

    E-Print Network [OSTI]

    Hinow, Peter

    Summary Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient powders variation in the drug release profile of the tablet. While fabrication of experimental tablets

  2. Fluid Delivery System For Capillary Electrophoretic Applications.

    DOE Patents [OSTI]

    Li, Qingbo (State College, PA); Liu, Changsheng (State College, PA); Kane, Thomas E. (State College, PA); Kernan, John R. (Loganton, PA); Sonnenschein, Bernard (Brooklyn, NY); Sharer, Michael V. (Tyrone, PA)

    2002-04-23

    An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a gel delivery module containing a gel syringe/a stepper motor or a high pressure chamber with a pump to quickly and uniformly deliver gel through the capillary tubes. The system further includes a multi-wavelength beam generator to generate a laser beam which produces a beam with a wide range of wavelengths. An off-line capillary reconditioner thoroughly cleans a capillary cartridge to enable simultaneous execution of electrophoresis with another capillary cartridge. The streamlined nature of the off-line capillary reconditioner offers the advantage of increased system throughput with a minimal increase in system cost.

  3. Multiple-robot drug delivery strategy through coordinated teams of microswimmers

    SciTech Connect (OSTI)

    Kei Cheang, U; Kim, Min Jun; Lee, Kyoungwoo; Julius, Anak Agung

    2014-08-25

    Untethered robotic microswimmers are very promising to significantly improve various types of minimally invasive surgeries by offering high accuracy at extremely small scales. A prime example is drug delivery, for which a large number of microswimmers is required to deliver sufficient dosages to target sites. For this reason, the controllability of groups of microswimmers is essential. In this paper, we demonstrate simultaneous control of multiple geometrically similar but magnetically different microswimmers using a single global rotating magnetic field. By exploiting the differences in their magnetic properties, we triggered different swimming behaviors from the microswimmers by controlling the frequency and the strength of the global field, for example, one swim and the other does not while exposed to the same control input. Our results show that the balance between the applied magnetic torque and the hydrodynamic torque can be exploited for simultaneous control of two microswimmers to swim in opposite directions, with different velocities, and with similar velocities. This work will serve to establish important concepts for future developments of control systems to manipulate multiple magnetically actuated microswimmers and a step towards using swarms of microswimmers as viable workforces for complex operations.

  4. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release is controlled by polymer degradation

  5. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    1 Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable The biodegradable polymer such as poly(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release

  6. Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery

    E-Print Network [OSTI]

    S. Heidegger; S. Niedermayer; A. Schmidt; D. Gößl; C. Argyo; S. Endres; T. Bein; C. Bourquin

    2015-09-03

    Multifunctional mesoporous silica nanoparticles (MSN) have attracted substantial attention with regard to their high potential for targeted drug delivery. For future clinical applications it is crucial to address safety concerns and understand the potential immunotoxicity of these nanoparticles. In this study, we assess the biocompatibility and functionality of multifunctional MSN in freshly isolated, primary murine immune cells. We show that the functionalized silica nanoparticles are rapidly and efficiently taken up into the endosomal compartment by specialized antigen-presenting cells such as dendritic cells. The silica nanoparticles showed a favorable toxicity profile and did not affect the viability of primary immune cells from the spleen in relevant concentrations. Cargo-free MSN induced only very low immune responses in primary cells as determined by surface expression of activation markers and release of pro-inflammatory cytokines such as Interleukin-6, -12 and -1\\beta. In contrast, when surface-functionalized MSN with a pH-responsive polymer capping were loaded with an immune-activating drug, the synthetic Toll-like receptor 7 agonist R848, a strong immune response was provoked. We thus demonstrate that MSN represent an efficient drug delivery vehicle to primary immune cells that is both non-toxic and non-inflammagenic, which is a prerequisite for the use of these particles in biomedical applications.

  7. Optical diagnostics integrated with laser spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

    2008-09-02

    A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

  8. Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth

    E-Print Network [OSTI]

    Wong, Cliff R. (Cliff Richard)

    2011-01-01

    Assembly of functional nanocomponents offers promising applications in drug delivery to solid tumors and bottom-up synthesis and integration of nanodevices. This thesis presents a novel multistage nanoparticle delivery ...

  9. Composite gelatin delivery system for bone regeneration

    E-Print Network [OSTI]

    Hager, Elizabeth A. (Elizabeth Ann)

    2005-01-01

    In this thesis, the chemical/mechanical properties and biocompatibility of gelatin were investigated to produce a gelatin scaffold for the release of bone morphogenetic proteins (BMPs) from composite particles. This delivery ...

  10. Water delivery in the Early Solar System

    E-Print Network [OSTI]

    Dvorak, Rudolf; Süli, Áron; Sándor, Zsolt; Galiazzo, Mattia; Pilat-Lohinger, Elke

    2015-01-01

    As part of the national scientific network 'Pathways to Habitable Worlds' the delivery of water onto terrestrial planets is a key question since water is essential for the development of life as we know it. After summarizing the state of the art we show some first results of the transport of water in the early Solar System for scattered main belt objects. Hereby we investigate the questions whether planetesimals and planetesimal fragments which have gained considerable inclination due to the strong dynamical interactions in the main belt region around 2 AU can be efficient water transporting vessels. The Hungaria asteroid group is the best example that such scenarios are realistic. Assuming that the gas giants and the terrestrial planets are already formed, we monitor the collisions of scattered small bodies containing water (in the order of a few percent) with the terrestrial planets. Thus we are able to give a first estimate concerning the respective contribution of such bodies to the actual water content i...

  11. Computer controlled feed delivery system for feed trucks 

    E-Print Network [OSTI]

    Holt, Gregory Alan

    1989-01-01

    COMPUTER CONTROLLED FEED DELIVERY SYSTEM FOR FEED TRUCKS A Thesis by GREGORY ALAN HOLT Submitted to the Office of Graduate Studies of Texas ABM University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE August... 1989 Major Subject: Agricultural Engineering COMPIJIER CONTROLLED FEED DELIVERY SYSTEM FOR FEED TRUCKS A Thesis by GREGORY ALAN HOLT Approved as to style and content by: Calvin B. Parnell (Chair of Committee) ayne LePori (Member) Charlie G...

  12. Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen

    Broader source: Energy.gov [DOE]

    Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen.Solid and liquid hydrogen carriers for use in hydrogen storage and delivery.

  13. Nanoparticle Agglomeration via Ionic Colloidal Destabilization as a Novel Approach to Dry Powder Formulations for Pulmonary Drug Delivery

    E-Print Network [OSTI]

    Plumley, Carl Joseph

    2008-08-05

    suspension of stable charged nanoparticles (NP). Stearic acid allowed for stabilization of the resulting colloid, and facilitated destabilization with the addition of electrolytes. The resulting nanoparticle agglomerates demonstrated excellent aerosol... the controlled agglomeration of nanoparticles in colloidal suspension for the fabrication of pure drug porous microparticles for pulmonary delivery. A model drug, nifedipine, was used in the study due to its current lack of attention in pulmonary formulations...

  14. Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery

    E-Print Network [OSTI]

    Heidegger, S; Schmidt, A; Gößl, D; Argyo, C; Endres, S; Bein, T; Bourquin, C

    2015-01-01

    Multifunctional mesoporous silica nanoparticles (MSN) have attracted substantial attention with regard to their high potential for targeted drug delivery. For future clinical applications it is crucial to address safety concerns and understand the potential immunotoxicity of these nanoparticles. In this study, we assess the biocompatibility and functionality of multifunctional MSN in freshly isolated, primary murine immune cells. We show that the functionalized silica nanoparticles are rapidly and efficiently taken up into the endosomal compartment by specialized antigen-presenting cells such as dendritic cells. The silica nanoparticles showed a favorable toxicity profile and did not affect the viability of primary immune cells from the spleen in relevant concentrations. Cargo-free MSN induced only very low immune responses in primary cells as determined by surface expression of activation markers and release of pro-inflammatory cytokines such as Interleukin-6, -12 and -1\\beta. In contrast, when surface-funct...

  15. Vulnerability Analysis of Energy Delivery Control Systems

    Office of Environmental Management (EM)

    system. Some vendors have integrators who work with customers to create and install the system. Other vendors have just a product model. Often, integration consultants with...

  16. Distributed Power Delivery for Energy Efficient and Low Power Systems

    E-Print Network [OSTI]

    Friedman, Eby G.

    Distributed Power Delivery for Energy Efficient and Low Power Systems Selc¸uk K¨ose Department are needed to determine the location of these on-chip power supplies and decoupling capacitors. In this paper, the optimal location of the power supplies and decoupling capacitors is determined for different size

  17. Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating

    E-Print Network [OSTI]

    Zhu, Xiaoxiang, Ph. D. Massachusetts Institute of Technology

    2014-01-01

    Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant ...

  18. Use of Supervisory Control and Data Acquisition for Damage Location of Water Delivery Systems

    E-Print Network [OSTI]

    Shinozuka, Masanobu

    Use of Supervisory Control and Data Acquisition for Damage Location of Water Delivery Systems Masanobu Shinozuka1 ; Jianwen Liang2 ; and Maria Q. Feng3 Abstract: Urban water delivery systems can, this paper develops a methodology to detect and locate the damage in a water delivery system by monitoring

  19. Steerable/distance enhanced penetrometer delivery system

    SciTech Connect (OSTI)

    Amini, A.; Boyd, G.M.

    1996-12-31

    Characterization, monitoring, and remediation of many of the nation`s highly contaminated sites are high priority at DOE. Penetrometers are often used for rapid characterization of underground contamination (plumes). Because of their heavy weight, use of penetrometer trucks over shallow buried storage tanks is restricted and risky. To close this gap, UTD developed a new position location device for penetrometers, called POLO (POsition LOcator), which provides real- time position location without blocking downhole access for environmental sensors. UTD also developed a system to make penetrometers steerable and capable of deeper penetration. Products of this work is a Steerable Vibratory System, which a relatively lightweight rig capable of greater penetration than traditional penetrometers of the same weight.

  20. Miniature Videoprobe Hockey Stick Delivery System

    SciTech Connect (OSTI)

    Hale, Lester R.; McMurry, Kyle M.

    1998-06-18

    The present invention is a miniature videoprobe system having a probe termination box, a strong back, and a videoprobe housing. The videoprobe system is able to obtain images from a restricted space at least as small as 0.125 inches while producing a high quality image. The strong back has a hockey stick shape with the probe termination box connecting to the top of the handle-like portion of the hockey stick and the videoprobe housing attaching to the opposite end or nose of the hockey stick shape. The videoprobe housing has a roughly arrowhead shape with two thin steel plates sandwiching the internal components there between. The internal components are connected in series to allow for a minor dimension of the videoprobe housing of 0.110 inches. The internal components include an optics train, a CCD chip, and an electronics package. An electrical signal is transmitted from the electronics package through wiring within an internal channel of the strong back to the probe termination box. The strong back has milled into it multiple internal channels for facilitating the transfer of information, items, or devices between the probe termination box and the videoprobe housing.

  1. Feasibility Study: Ductless Hydronic Distribution Systems with Fan Coil Delivery

    SciTech Connect (OSTI)

    Springer, D.; Dakin, B.; Backman, C.

    2012-07-01

    The primary objectives of this study are to estimate potential energy savings relative to conventional ducted air distribution, and to identify equipment requirements, costs, and barriers with a focus on ductless hydronic delivery systems that utilize water-to-air terminal units in each zone. Results indicate that annual heating and cooling energy use can be reduced by up to 27% assuming replacement of the conventional 13 SEER heat pump and coil with a similarly rated air-to-water heat pump.

  2. Systems Theory for Pharmaceutical Drug Discovery

    E-Print Network [OSTI]

    Aswani, Anil Jayanti

    2010-01-01

    model to identify multiple drug targets which can be candidates for the traditional process of drug discovery.

  3. Hollow-waveguide delivery systems for high-power, industrial CO2 lasers

    E-Print Network [OSTI]

    Hollow-waveguide delivery systems for high-power, industrial CO2 lasers Ricky K. Nubling and James to deliver CO2 laser power for industrial laser applications. The transmission, bending loss, and output, beam delivery, industrial lasers, power delivery, CO2 lasers. r 1996 Optical Society of America 1

  4. Reliability review of the remote tool delivery system locomotor

    SciTech Connect (OSTI)

    Chesser, J.B.

    1999-04-01

    The locomotor being built by RedZone Robotics is designed to serve as a remote tool delivery (RID) system for waste retrieval, tank cleaning, viewing, and inspection inside the high-level waste tanks 8D-1 and 8D-2 at West Valley Nuclear Services (WVNS). The RTD systm is to be deployed through a tank riser. The locomotor portion of the RTD system is designed to be inserted into the tank and is to be capable of moving around the tank by supporting itself and moving on the tank internal structural columns. The locomotor will serve as a mounting platform for a dexterous manipulator arm. The complete RTD system consists of the locomotor, dexterous manipulator arm, cameras, lights, cables, hoses, cable/hose management system, power supply, and operator control station.

  5. Biopolymer-Connected Liposome Networks as Injectable Biomaterials Capable of Sustained Local Drug Delivery

    E-Print Network [OSTI]

    Raghavan, Srinivasa

    Biopolymer-Connected Liposome Networks as Injectable Biomaterials Capable of Sustained Local Drug-20 Such hybrid gels could be used in applications that require implantable biomaterials; however, most

  6. The Vacuum System for the TESLA Beam Delivery System A. Brenger, K. Rehlich, K. Zapfe

    E-Print Network [OSTI]

    1 The Vacuum System for the TESLA Beam Delivery System A. Brenger, K. Rehlich, K. Zapfe Deutsches-power beam dumps. The vacuum system is required to maintain an average pressure of 1·10-8 mbar (CO/N2 equiva enough not to disturb the vacuum in the main beam line. For pumping ion getter pumps will be used

  7. AcceptedPreprint Tissue Engineering and Delivery Systems Biotechnology and Bioengineering

    E-Print Network [OSTI]

    Yanikoglu, Berrin

    AcceptedPreprint 1 Tissue Engineering and Delivery Systems Biotechnology and Bioengineering DOI 10 Sciences, Sabanci University, Istanbul 34956, Turkey 2 Biological Sciences & Bioengineering, Faculty

  8. Polarimeters and Energy Spectrometers for the ILC Beam Delivery System

    SciTech Connect (OSTI)

    Boogert, S.; /Royal Holloway, U. of London; Hildreth, M.; /Notre Dame U.; Kafer, D.; List, J.; Monig, K.; /DESY; Moffeit, K.C.; /SLAC; Moortgat-Pick, G.; /Durham U., IPPP; Riemann, S.; Schreiber, H.J.; Schuler, P.; /DESY; Torrence, E.; /Oregon U.; Woods, M.; /SLAC

    2009-02-24

    This article gives an overview of current plans and issues for polarimeters and energy spectrometers in the Beam Delivery System of the ILC. It is meant to serve as a useful reference for the Detector Letter of Intent documents currently being prepared. Concepts for high precision polarization and energy measurements exist. These concepts have resulted in detailed system layouts that are included in the RDR description for the Beam Delivery System. The RDR includes both upstream and downstream polarimeters and energy spectrometers for both beams. This provides needed complementarity and redundancy for achieving the precision required, with adequate control and demonstration of systematic errors. The BDS polarimeters and energy spectrometers need to be a joint effort of the ILC BDS team and the Detector collaborations, with collaboration members responsible for the performance and accuracy of the measurements. Details for this collaboration and assigning of responsibilities remain to be worked out. There is also a demonstrated need for Detector physicists to play an active role in the design and evaluation of accelerator components that impact beam polarization and beam energy capabilities, including the polarized source and spin rotator systems. A workshop was held in 2008 on ILC Polarization and Energy measurements, which resulted in a set of recommendations for the ILC design and operation. Additional input and action is needed on these from the Detector collaborations, the Research Director and the GDE. Work is continuing during the ILC engineering design phase to further optimize the polarimeter and energy spectrometer concepts and fully implement them in the ILC. This includes consideration for alternative methods, detailed design and cost estimates, and prototype and test beam activities.

  9. 14:125:445 -Engineering Principles of Drug Delivery Spring 2012 -Course Outline

    E-Print Network [OSTI]

    Muzzio, Fernando J.

    of amphiphilic molecules 2. comprehend within the framework of the biological milieu, the role of intermolecular) Engineering Principles for Drug Therapy, W. Mark Saltzman, Oxford University Press (2001), (2) Random Walks

  10. Fabrication of complex oral drug delivery forms by Three Dimensional Printing (tm)

    E-Print Network [OSTI]

    Katstra, Wendy E. (Wendy Ellen), 1974-

    2001-01-01

    Three Dimensional Printing 3DPTM is a novel solid freeform fabrication technology that has been applied to the fabrication of complex pharmaceutical drug devices. Limitations of the technology as relating to pharmaceuticals ...

  11. Multiple delivery cesium oven system for negative ion sources

    SciTech Connect (OSTI)

    Bansal, G.; Bhartiya, S.; Pandya, K.; Bandyopadhyay, M.; Singh, M. J.; Soni, J.; Gahlaut, A.; Parmar, K. G.; Chakraborty, A. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat 382428 (India)

    2012-02-15

    Distribution of cesium in large negative ion beam sources to be operational in ITER, is presently based on the use of three or more cesium ovens, which operate simultaneously and are controlled remotely. However, use of multiple Cs ovens simultaneously is likely to pose difficulties in operation and maintenance of the ovens. An alternate method of Cs delivery, based on a single oven distribution system is proposed as one which could reduce the need of simultaneous operation of many ovens. A proof of principle experiment verifying the concept of a multinozzle distributor based Cs oven has been carried out at Institute for Plasma Research. It is also observed that the Cs flux is not controlled by Cs reservoir temperature after few hours of operation but by the temperature of the distributor which starts behaving as a Cs reservoir.

  12. Rapid cycling medical synchrotron and beam delivery system

    DOE Patents [OSTI]

    Peggs, Stephen G. (Port Jefferson, NY); Brennan, J. Michael (East Northport, NY); Tuozzolo, Joseph E. (Sayville, NY); Zaltsman, Alexander (Commack, NY)

    2008-10-07

    A medical synchrotron which cycles rapidly in order to accelerate particles for delivery in a beam therapy system. The synchrotron generally includes a radiofrequency (RF) cavity for accelerating the particles as a beam and a plurality of combined function magnets arranged in a ring. Each of the combined function magnets performs two functions. The first function of the combined function magnet is to bend the particle beam along an orbital path around the ring. The second function of the combined function magnet is to focus or defocus the particle beam as it travels around the path. The radiofrequency (RF) cavity is a ferrite loaded cavity adapted for high speed frequency swings for rapid cycling acceleration of the particles.

  13. Magnetic Resonant Wireless Power Delivery for Distributed Sensor and Wireless Systems

    E-Print Network [OSTI]

    Cervesato, Iliano

    Magnetic Resonant Wireless Power Delivery for Distributed Sensor and Wireless Systems Brian J. Lee, Andrew Hillenius and David S. Ricketts Electrical & Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213 Abstract-- In this paper we report on a resonant wireless power delivery system using

  14. The design and evaluation of a water delivery system for evaporative cooling of a proton exchange membrane fuel cell 

    E-Print Network [OSTI]

    Al-Asad, Dawood Khaled Abdullah

    2009-06-02

    An investigation was performed to demonstrate system design for the delivery of water required for evaporative cooling of a proton exchange membrane fuel cell (PEMFC). The water delivery system uses spray nozzles capable of injecting water directly...

  15. Wakefield Effects in the Beam Delivery System of the ILC

    SciTech Connect (OSTI)

    Bane, K.L.F.; Seryi, A.; /SLAC

    2007-06-27

    The main linac of the International Linear Collider (ILC) accelerates short, high peak current bunches into the Beam Delivery System (BDS) on the way to the interaction point. In the BDS wakefields, excited by the resistance of the beam pipe walls and by beam pipe transitions, will tend to degrade the emittance of the beam bunches. In this report we calculate the effect on single bunch emittance of incoming jitter or drift, and of misalignments of the beam pipes with respect to the beam axis, both analytically and through multi-particle tracking. As we want to keep emittance growth due to this effect small, we consider also mitigation measures of changing the metallic surface material and/or the beam pipe aperture. The wake effects are studied in that part of the BDS which includes the collimation and final focus systems. Typical ILC beam parameters are given in Table 1. Initially a stainless steel (SS) beam pipe is considered. Note that the ILC collimator wakes, though very important, are not included in this study; their effects have been studied elsewhere [1]. Note also that similar methods are presented in recent reports Refs. [2],[3].

  16. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Forte, Trudy

    2011-04-28

    Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

  17. Cesium Delivery System for Negative Ion Source at IPR

    SciTech Connect (OSTI)

    Bansal, G.; Pandya, K.; Soni, J.; Gahlaut, A.; Parmar, K. G. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat, 382 428 (India); Bandyopadhyay, M.; Chakraborty, A.; Singh, M. J. [ITER- India, Institute for Plasma Research, A-29, Sector 25, GIDC, Gandhinagar, Gujarat (India)

    2011-09-26

    The technique of surface production of negative ions using cesium, Cs, has been efficiently exploited over the years for producing negative ion beams with increased current densities from negative ion sources used on neutral beam lines. Deposition of Cs on the source walls and the plasma grid lowers the work function and therefore enables a higher yield of H{sup -}, when hydrogen particles (H and/or H{sub x}{sup +}) strike these surfaces.A single driver RF based (100 kW, 1 MHz) negative ion source test bed, ROBIN, is being set up at IPR under a technical collaboration between IPR and IPP, Germany. The optimization of the Cs oven design to be used on this facility as well as multidriver sources is underway. The characterization experiments of such a Cs delivery system with a 1 g Cs inventory have been carried out using surface ionization technique. The experiments have been carried by delivering Cs into a vacuum chamber without plasma. The linear motion of the surface ionization detector, SID, attached with a linear motion feedthrough allows measuring the angular distribution of the Cs coming out of the oven. Based on the experimental results, a Cs oven for ROBIN has been proposed. The Cs oven design and experimental results of the prototype Cs oven are reported and discussed in the paper.

  18. Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites

    E-Print Network [OSTI]

    Perelman, Loren Avery

    2008-01-01

    hybrid’ s OT returns to its original value, demonstrating the reversibility of the system through heating-system Figure 4.4 Optical thickness changes of a porous SiO 2 /poly(NIPAM) hybrid upon three consecutive heating/

  19. Cost Comparison of Public Elementary School Construction Costs Based on Project Delivery System in the State of Texas 

    E-Print Network [OSTI]

    Reinisch, Ashley

    2012-02-14

    the relationship between cost and project delivery systems. A survey was sent to all school superintendents in Texas requesting recent data on elementary school enrollment, project delivery type and construction costs. One hundred and thirty six responses were...

  20. Strategies for combinatorial development of siRNA conjugate delivery systems

    E-Print Network [OSTI]

    Kanasty, Rosemary L

    2015-01-01

    RNA interference (RNAi), which can reversibly silence the expression of any gene, has vast potential as a therapeutic to treat many diseases. A wide variety of small interfering RNA (siRNA) delivery systems has been studied, ...

  1. The National Engineering Education Delivery System (NEEDS): A Multimedia Digital Library of Courseware1

    E-Print Network [OSTI]

    Agogino, Alice M.

    1 The National Engineering Education Delivery System (NEEDS): A Multimedia Digital Library the diverse needs of curricula among a cross section of universities? How can educators modify their role

  2. Lymphocyte-mediated drug nanoparticle delivery to disseminated lymphoma tumors in vivo

    E-Print Network [OSTI]

    Huang, Bonnie

    2013-01-01

    The dissemination of lymphoma into anatomical compartments that are poorly accessible from circulation, such as lymph nodes, necessitates high doses of systemic chemotherapy. However, the potencies of many chemotherapeutic ...

  3. Evaluation & design of a novel drug delivery device for treating tumor-related cerebral edema

    E-Print Network [OSTI]

    Shair, Kamal A. (Kamal Abdo)

    2010-01-01

    Tumor-related cerebral edema is a debilitating medical condition that afflicts tens of thousands of newly diagnosed brain cancer patients in the U.S. each year, where the standard care of treatment indicates the systemic ...

  4. Multistage nanoparticle delivery system for deep penetration into tumor

    E-Print Network [OSTI]

    Wong, Cliff

    Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...

  5. Control system and method for a power delivery system having a continuously variable ratio transmission

    DOE Patents [OSTI]

    Frank, Andrew A. (1034 Hillside Ave., Madison, WI 53705)

    1984-01-01

    A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine.

  6. Control system and method for a power delivery system having a continuously variable ratio transmission

    DOE Patents [OSTI]

    Frank, A.A.

    1984-07-10

    A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine. 4 figs.

  7. Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release

    E-Print Network [OSTI]

    Stefan Datz; Christian Argyo; Michael Gattner; Veronika Weiss; Korbinian Brunner; Johanna Bretzler; Constantin von Schirnding; Fabio Spada; Hanna Engelke; Milan Vrabel; Christoph Bräuchle; Thomas Carell; Thomas Bein

    2015-10-13

    Effective and controlled drug delivery systems with on-demand release and targeting abilities have received enormous attention for biomedical applications. Here, we describe a novel enzyme-based cap system for mesoporous silica nanoparticles (MSNs) that is directly combined with a targeting ligand via bio-orthogonal click chemistry. The capping system is based on the pH-responsive binding of an aryl-sulfonamide-functionalized MSN and the enzyme carbonic anhydrase (CA). An unnatural amino acid (UAA) containing a norbornene moiety was genetically incorporated into CA. This UAA allowed for the site-specific bio-orthogonal attachment of even very sensitive targeting ligands such as folic acid and anandamide. This leads to specific receptor-mediated cell and stem cell uptake. We demonstrate the successful delivery and release of the chemotherapeutic agent Actinomycin D to KB cells. This novel nanocarrier concept provides a promising platform for the development of precisely controllable and highly modular theranostic systems.

  8. An Implantable Bio-Micro-system for Drug Monitoring

    E-Print Network [OSTI]

    De Micheli, Giovanni

    An Implantable Bio-Micro-system for Drug Monitoring Sara Ghoreishizadeh, Enver G. Kilinc, Camilla of the implantable monitoring system for long- term duration has many challenges. First, a multi-target biosen- sor coil; (ii) A power manage- ment IC dealing with the energy source of the implantable microsystem

  9. Stimuli Responsive Polymers for Enhanced Drug Release Applications

    E-Print Network [OSTI]

    Tam, Michael K. C.

    This talk will focus on the development of polymeric nano-structured systems for drug and gene delivery applications. Two major classes of polymer systems will be considered; namely poly(ethylene-oxide-b-propylene-oxide- ...

  10. Error Types, Risk Assessment, & the Technology Delivery System for RESIN

    E-Print Network [OSTI]

    Roe, Emery

    2010-01-01

    reliability of electricity transmission has as well dependednot shared by the electricity transmission system protectedwe not want the electricity transmission system behind that

  11. Electrical-Thermal Co-analysis for Power Delivery Networks in 3D System Integration

    E-Print Network [OSTI]

    Swaminathan, Madhavan

    Electrical-Thermal Co-analysis for Power Delivery Networks in 3D System Integration Jianyong Xie1 Rubin3 1 School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332 2 IBM Package Design, Development, and Electrical Services Group, Poughkeepsie, N.Y. 12601 3 IBM T

  12. JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, VOL. 12, NO. 6, DECEMBER 2003 947 Power Delivery and Locomotion of

    E-Print Network [OSTI]

    Richardson, David

    JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, VOL. 12, NO. 6, DECEMBER 2003 947 Power Delivery in a way that does not restrain the device's motion. This paper presents a MEMS actu- ator that operates power to un- tethered MEMS devices, independently of the position and orienta- tion of those devices

  13. seminar abstract Intradermal Delivery of Nanoparticle Vaccine Formulation via Microneedle

    E-Print Network [OSTI]

    Thomas, David D.

    and other strategies such as iontophoresis were developed to increase drug delivery efficiency.(Prausnitz

  14. Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery

    E-Print Network [OSTI]

    Vukmirovic, Neda

    2007-01-01

    Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what ...

  15. System and method for delivery of neutron beams for medical therapy

    DOE Patents [OSTI]

    Nigg, David W. (Idaho Falls, ID); Wemple, Charles A. (Idaho Falls, ID)

    1999-01-01

    A neutron delivery system that provides improved capability for tumor control during medical therapy. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention.

  16. System and method for delivery of neutron beams for medical therapy

    DOE Patents [OSTI]

    Nigg, D.W.; Wemple, C.A.

    1999-07-06

    A neutron delivery system that provides improved capability for tumor control during medical therapy is disclosed. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention. 5 figs.

  17. Systems and methods for bi-directional energy delivery with galvanic isolation

    DOE Patents [OSTI]

    Kajouke, Lateef A.

    2013-06-18

    Systems and methods are provided for bi-directional energy delivery. A charging system comprises a first bi-directional conversion module, a second bi-directional conversion module, and an isolation module coupled between the first bi-directional conversion module and the second bi-directional conversion module. The isolation module provides galvanic isolation between the first bi-directional conversion module and the second bi-directional conversion module.

  18. Methodology for the production and delivery of generative music for the personal listener : systems for realtime generative music production 

    E-Print Network [OSTI]

    Murphy, Michael J.

    2013-11-27

    This thesis will describe a system for the production of generative music through specific methodology, and provide an approach for the delivery of this material. The system and body of work will be targeted specifically ...

  19. Electrical swing adsorption gas storage and delivery system

    DOE Patents [OSTI]

    Judkins, Roddie R. (Knoxville, TN); Burchell, Timothy D. (Oak Ridge, TN)

    1999-01-01

    Systems and methods for electrical swing natural gas adsorption are described. An apparatus includes a pressure vessel; an electrically conductive gas adsorptive material located within the pressure vessel; and an electric power supply electrically connected to said adsorptive material. The adsorptive material can be a carbon fiber composite molecular sieve (CFCMS). The systems and methods provide advantages in that both a high energy density and a high ratio of delivered to stored gas are provided.

  20. Electrical swing adsorption gas storage and delivery system

    DOE Patents [OSTI]

    Judkins, R.R.; Burchell, T.D.

    1999-06-15

    Systems and methods for electrical swing natural gas adsorption are described. An apparatus includes a pressure vessel; an electrically conductive gas adsorptive material located within the pressure vessel; and an electric power supply electrically connected to said adsorptive material. The adsorptive material can be a carbon fiber composite molecular sieve (CFCMS). The systems and methods provide advantages in that both a high energy density and a high ratio of delivered to stored gas are provided. 5 figs.

  1. Alveolar targeting of aerosol pentamidine. Toward a rational delivery system

    SciTech Connect (OSTI)

    Simonds, A.K.; Newman, S.P.; Johnson, M.A.; Talaee, N.; Lee, C.A.; Clarke, S.W. )

    1990-04-01

    Nebulizer systems that deposit a high proportion of aerosolized pentamidine on large airways are likely to be associated with marked adverse side effects, which may lead to premature cessation of treatment. We have measured alveolar deposition and large airway-related side effects (e.g., cough, breathlessness, and effect on pulmonary function) after aerosolization of 150 mg pentamidine isethionate labeled with {sup 99m}Tc-Sn-colloid. Nine patients with AIDS were studied using three nebulizer systems producing different droplet size profiles: the Acorn System 22, Respirgard II, and Respirgard II with the inspiratory baffle removed. Alveolar deposition was greatest and side effects least with the nebulizer producing the smallest droplet size profile (Respirgard II), whereas large airway-related side effects were prominent and alveolar deposition lowest with the nebulizer producing the largest droplet size (Acorn System 22). Values for alveolar deposition and adverse airway effects were intermediate using the Respirgard with inspiratory baffle removed, thus indicating the importance of the baffle valve in determining droplet size. Addition of a similar baffle valve to the Acorn System 22 produced a marked improvement in droplet size profile. Selection of a nebulizer that produces an optimal droplet size range offers the advantage of enhancing alveolar targeting of aerosolized pentamidine while reducing large airway-related side effects.

  2. Decision Support System for integrated door-to-door delivery

    E-Print Network [OSTI]

    Ducatelle, Frederick

    , responsible for traffic infra- structure, while the demand side is constituted by production and trans on the demand side and support planning on the supply side. The objectives of the supply-oriented system, filtered and aggregated suitably to become information with added value. MOSCA Homepage - www

  3. Alternate Air Delivery Systems for Hot and Humid Climates 

    E-Print Network [OSTI]

    Wallace, M.

    1996-01-01

    Carter & Burgess first began using triple deck multi-zone units, in place of traditional VAV systems, on the Texas State Capitol restoration. Since the completion of that project design in early 1991, our firm has now used triple deck multi...

  4. Management of Leaks in Hydrogen Production, Delivery, and Storage Systems

    SciTech Connect (OSTI)

    Rawls, G

    2006-04-27

    A systematic approach to manage hydrogen leakage from components is presented. Methods to evaluate the quantity of hydrogen leakage and permeation from a system are provided by calculation and testing sensitivities. The following technology components of a leak management program are described: (1) Methods to evaluate hydrogen gas loss through leaks; (2) Methods to calculate opening areas of crack like defects; (3) Permeation of hydrogen through metallic piping; (4) Code requirements for acceptable flammability limits; (5) Methods to detect flammable gas; (6) Requirements for adequate ventilation in the vicinity of the hydrogen system; (7) Methods to calculate dilution air requirements for flammable gas mixtures; and (8) Concepts for reduced leakage component selection and permeation barriers.

  5. A Feasibility Study: Ductless Hydronic Distribution Systems with Fan Coil Delivery

    SciTech Connect (OSTI)

    D. Springer, B. Dakin, and C. Backman

    2012-07-01

    The primary objectives of this study are to estimate potential energy savings relative to conventional ducted air distribution, and to identify equipment requirements, costs, and barriers with a focus on ductless hydronic delivery systems that utilize water-to-air terminal units in each zone. Results indicate that annual heating and cooling energy use can be reduced by up to 27% assuming replacement of the conventional 13 SEER heat pump and coil with a similarly rated air-to-water heat pump.

  6. Cost and Area Comparison Per Student of the Public Elementary Schools in Texas based on the Project Delivery Systems 

    E-Print Network [OSTI]

    Goyal Rakesh, Sheetal

    2013-08-09

    It has been shown that there exists a correlation between the cost of construction of elementary schools and the project delivery systems. Previous research showed that Competitive Sealed proposal contract method of construction is $4000 cheaper...

  7. Source and Extraction for Simultaneous Four-hall Beam Delivery System at CEBAF

    SciTech Connect (OSTI)

    Kazimi, Reza; Wang, Haipeng; Spata, Mike F.; Hansknecht, John C.

    2013-06-01

    A new design for simultaneous delivery of the electron beam to all four 12 GeV CEBAF experimental halls* requires a new 750 MHz RF separator system in the 5th pass extraction region, a 250 MHz repetition rate for its beams, and addition of a fourth laser at the photo-cathode gun. The proposed system works in tandem with the existing 500 MHz RF separators and beam repetition rate on the lower passes. The new 5th pass RF separators will have the same basic design but modified to run at 750 MHz. The change to the beam repetition rate will be at the photo-cathode gun through an innovative upgrade of the seed laser driver system using electro-optic modulators. The new laser system also allows addition of the fourth laser. The new RF separators, the new laser system and other hardware changes required to implement the Four-Hall operation delivery system will be discussed in this paper.

  8. Nonlinear Decelerator for Payloads in Aerial Delivery Systems. I: Design and Testing

    E-Print Network [OSTI]

    T. Lyons; M. Ginther; P. Mascarenas; E. Rickard; J. Robinson; J. Braeger; H. Liu; A. Ludu

    2014-08-19

    We study the dynamics and the optimization of the shock deceleration supported by a payload when its airborne carrier impacts the ground. We build a nonlinear elastic model for a container prototype and an elastic suspension system for the payload. We model the dynamics of this system and extract information on maximum deceleration, energy transfer between the container and payload, and energy resonant damping. We designed the system and perform lab experiments for various terminal velocities and types of grounds (cement, grass, sand water, etc.). The results are compared with the theoretical model and results are commented, including predictions for deceleration at different types of ground impact. The results can be used for aerial delivery systems, splash-down of capsules, recoveries, weather balloons, coastal surveying systems, or the new introduced goal-line technology in sport competitions.

  9. Urban Sewage Delivery Heat Transfer System (1): Flow Resistance and Energy Analysis 

    E-Print Network [OSTI]

    Zhang, C.; Wu, R.; Li, G.; Li, X.; Huang, L.; Sun, D.

    2006-01-01

    , Shenzhen, China Renewable Energy Resources and a Greener Future Vol.VIII-8-4 Urban Sewage Delivery Heat Transfer System (1): Flow Resistance and Energy Analysis1 Chenghu Zhang Ronghua Wu Guitao Li Xin Li Lei Huang Dexing Sun Doctor Master...) By the numeric calculation and the simplification, the power function form, can be obtained, which is used in the engineering easily. It is 0.30 0.0235 w d? = (2) The result of (2) is slight bigger than that of (1), but the errors are within 3...

  10. A HYBRID INTELLIGENT SYSTEM FOR FORMULATION OF BCS CLASS II DRUGS IN HARD GELATIN CAPSULES

    E-Print Network [OSTI]

    Peng, Yun

    A HYBRID INTELLIGENT SYSTEM FOR FORMULATION OF BCS CLASS II DRUGS IN HARD GELATIN CAPSULES Gunjan in hard gelatin cap- sules. Several significant challenges are involved in drug- formulation: the active of drug formulations for hard gelatin capsules can present significant challenges [4]. Some

  11. Soil chemical sensor and precision agricultural chemical delivery system and method

    DOE Patents [OSTI]

    Colburn, Jr., John W. (Houston, TX)

    1991-01-01

    A real time soil chemical sensor and precision agricultural chemical delivery system includes a plurality of ground-engaging tools in association with individual soil sensors which measure soil chemical levels. The system includes the addition of a solvent which rapidly saturates the soil/tool interface to form a conductive solution of chemicals leached from the soil. A multivalent electrode, positioned within a multivalent frame of the ground-engaging tool, applies a voltage or impresses a current between the electrode and the tool frame. A real-time soil chemical sensor and controller senses the electrochemical reaction resulting from the application of the voltage or current to the leachate, measures it by resistivity methods, and compares it against pre-set resistivity levels for substances leached by the solvent. Still greater precision is obtained by calibrating for the secondary current impressed through solvent-less soil. The appropriate concentration is then found and the servo-controlled delivery system applies the appropriate amount of fertilizer or agricultural chemicals substantially in the location from which the soil measurement was taken.

  12. Soil chemical sensor and precision agricultural chemical delivery system and method

    DOE Patents [OSTI]

    Colburn, J.W. Jr.

    1991-07-23

    A real time soil chemical sensor and precision agricultural chemical delivery system includes a plurality of ground-engaging tools in association with individual soil sensors which measure soil chemical levels. The system includes the addition of a solvent which rapidly saturates the soil/tool interface to form a conductive solution of chemicals leached from the soil. A multivalent electrode, positioned within a multivalent frame of the ground-engaging tool, applies a voltage or impresses a current between the electrode and the tool frame. A real-time soil chemical sensor and controller senses the electrochemical reaction resulting from the application of the voltage or current to the leachate, measures it by resistivity methods, and compares it against pre-set resistivity levels for substances leached by the solvent. Still greater precision is obtained by calibrating for the secondary current impressed through solvent-less soil. The appropriate concentration is then found and the servo-controlled delivery system applies the appropriate amount of fertilizer or agricultural chemicals substantially in the location from which the soil measurement was taken. 5 figures.

  13. Internet-Based Delivery and Deployment of Document Management Systems Borko Furht, Florida Atlantic University, Boca Raton, Florida

    E-Print Network [OSTI]

    Furht, Borko

    Internet-Based Delivery and Deployment of Document Management Systems Borko Furht, Florida Atlantic Management Systems (DBMS). DBMS typically store structured data and short records, such as name, address management systems is based on the client/server architecture. Typically, the DMS runs on the corporate

  14. Evaluation of aftermarket fuel delivery systems for natural gas and LPG vehicles

    SciTech Connect (OSTI)

    Willson, B.

    1992-09-01

    This study was designed to evaluate the effectiveness of aftermarket fuel delivery systems for vehicles fueled by compressed natural gas (CNG) and liquefied petroleum gas (LPG). Most of the CNG and LPG vehicles studied were converted to the alternative fuel after purchase. There are wide variations in the quality of the conversion hardware and the installation. This leads to questions about the overall quality of the converted vehicles, in terms of emissions, safety, and performance. There is a considerable body of emissions data for converted light-duty vehicles, and a smaller amount for medium- and heavy-duty vehicles. However, very few of these data involve real world conditions, and there is growing concern about in-use emissions. This report also attempts to assess factors that could allow in-use emissions to vary from the ``best-case`` results normally reported. The study also addresses issues of fuel supply, fuel composition, performance, safety, and warranty waivers. The report is based on an extensive literature and product survey and on the author`s experience with fuel delivery systems for light-duty vehicles.

  15. Evaluation of aftermarket fuel delivery systems for natural gas and LPG vehicles

    SciTech Connect (OSTI)

    Willson, B. )

    1992-09-01

    This study was designed to evaluate the effectiveness of aftermarket fuel delivery systems for vehicles fueled by compressed natural gas (CNG) and liquefied petroleum gas (LPG). Most of the CNG and LPG vehicles studied were converted to the alternative fuel after purchase. There are wide variations in the quality of the conversion hardware and the installation. This leads to questions about the overall quality of the converted vehicles, in terms of emissions, safety, and performance. There is a considerable body of emissions data for converted light-duty vehicles, and a smaller amount for medium- and heavy-duty vehicles. However, very few of these data involve real world conditions, and there is growing concern about in-use emissions. This report also attempts to assess factors that could allow in-use emissions to vary from the best-case'' results normally reported. The study also addresses issues of fuel supply, fuel composition, performance, safety, and warranty waivers. The report is based on an extensive literature and product survey and on the author's experience with fuel delivery systems for light-duty vehicles.

  16. Drug discovery, design and development is an overarching theme for much of the research taking place through the University's Department of Pharmacy and Pharmacology.

    E-Print Network [OSTI]

    Burton, Geoffrey R.

    Drug discovery, design and development is an overarching theme for much of the research taking and central nervous system disorders such as epilepsy, depression, anxiety and drug abuse. The following. University of Bath Drug discovery and development at Bath #12;Tumour-selective delivery of potent drugs

  17. Tools and Methods for Hardening Communication Security of Energy Delivery Systems

    SciTech Connect (OSTI)

    Gadgil, Shrirang; Lin, Yow-Jian; Ghosh, Abhrajit; Samtani, Sunil; Kang, Jaewon; Siegell, Bruce; Kaul, Vikram; Unger, John; De Bruet, Andre; Martinez, Catherine; Vermeulen, Gerald; Rasche, Galen; Sternfeld, Scott; Berthier, Robin; Bobba, Rakesh; Campbell, Roy; Sanders, Williams; Lin, Yow-Jian

    2014-06-30

    This document summarizes the research and development work the TT Government Solutions (TTGS), d.b.a. Applied Communication Sciences (ACS), team performed for the Department of Energy Cybersecurity for Energy Delivery Systems (CEDS) program. It addresses the challenges in protecting critical grid control and data communication, including the identification of vulnerabilities and deficiencies of communication protocols commonly used in energy delivery systems (e.g., ICCP, DNP3, C37.118, C12.22), as well as the development of effective means to detect and prevent the exploitation of such vulnerabilities and deficiencies. The team consists of • TT Government Solutions (TTGS), a leading provider of communications solutions that has extensive experience in commercializing communications solutions. TTGS also has deep cyber security research and development expertise supporting a variety of customers. • University of Illinois at Urbana-Champaign (UIUC), a leader in the cyber security research for the power grid. UIUC brings unique experience in designing secure communication protocols to this project. • Electric Power Research Institute (EPRI), an independent nonprofit that conducts research and development relating to the generation, delivery and use of electricity for the benefit of the public. EPRI brings to this effort its extensive technical expertise and its utility connections, with members representing more than 90 percent of the electricity generated and delivered in the United States. • DTE Energy, the 10th largest electric utility in the US, which helps ensure that this project focuses on the needs of utilities and is rightly positioned to address the needs of the market place. We designed, developed, and demonstrated a modular and extensible ADEC-G (Agent-based, Distributed, Extensible Cybersecurity for the Grid) system for monitoring/detecting abnormal energy delivery systems (EDS) protocol usage and ensuring security coverage. Our approach consists of i. An online system with stateful model based checkers (SMBCs) that helps utilities monitor EDS protocol communication contexts and flag abnormal session behaviors; ii. An offline framework that security tool developers, operators, and auditors can use to verify security properties (leverages formal methods). The modular design of the ADEC-G online system enables its easy extension to cover added protocol features, to introduce new monitoring capabilities, and to apply to additional communication protocols. Its monitoring capabilities and user interface features also facilitate visibilities into ongoing communication patterns and quick grasps of suspicious communication activities. The offline framework provides a platform not only for rigorous validation of security coverage, but also for systematic refinement of checker design leveraging the counter traces generated by the model checking tool. The ADEC-G online monitoring/detection system and the offline validation framework are both operational and have been demonstrated in various settings. The ADEC-G online system has also been integrated into TTGS SecureSmart Managed Security Services offering and been employed to perform security assessment in a section of a utility’s operational network as well as in other Smart Grid security pilot project offerings. TTGS is also in discussions with several system integrators for incorporating the integrated SecureSmart Managed Security Services offering as the cyber security solution for the nce of Operations Technology (OT) and Information Technology (IT).

  18. Vaccine delivery with microneedle skin patches in nonhuman primates

    E-Print Network [OSTI]

    Li, Adrienne V

    Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. However, to achieve efficient delivery of vaccines and other macromolecular therapeutics ...

  19. Using the National Engineering Education Delivery System as the Foundation for Building a Test-Bed Digital Library for

    E-Print Network [OSTI]

    Agogino, Alice M.

    community proposed for the National SMETE Digital Library (NSDL) [1, 2, 3, 4, 5]. The current systemUsing the National Engineering Education Delivery System as the Foundation for Building a Test-Bed Digital Library for Science, Mathematics, Engineering and Technology Education Final Report for NSF Grant

  20. Penetration of gas delivery systems in the United States: A state-level data analysis

    SciTech Connect (OSTI)

    Guldmann, J.M. . Environmental Assessment and Information Sciences Div. Ohio State Univ., Columbus, OH )

    1990-02-01

    The purpose of this study is to assess the degree to which the gas delivery infrastructure penetrates US regions and states and to pinpoint those areas in which the lack of a sufficient infrastructure impedes the expansion of the natural gas market. Regions and states are ranked according to several indicators developed with data published by the American Gas Association, the US Department of Energy/Energy Information Administration, and the US Bureau of the Census. These include the numbers of gas customers and gas deliveries by sector, mileages of distribution and transmission pipelines, underground storage capacities and operating characteristics, heating degree-days, populations and numbers of households, and areal measures of states and metropolitan areas. The market penetration of gas distribution systems is measured by two indicators: (1) the ratio of the number of residential gas customers to the number of households in 1985 and (2) the distribution pipeline density, measured by the ratio of the 1985 distribution mileage divided by the number of households, while accounting for the effect of urban population density (using earlier econometric results). 11 refs., 1 fig., 27 tabs.

  1. Nanostructured gene and drug delivery systems based on molecular self-assembly

    E-Print Network [OSTI]

    Wood, Kris Cameron

    2007-01-01

    Molecular self-assembly describes the assembly of molecular components into complex, supramolecular structures governed by weak, non-covalent interactions. In recent years, molecular self-assembly has been used extensively ...

  2. Development of a Light Actuated Drug Delivery-on-Demand System

    E-Print Network [OSTI]

    Linsley, Chase Schilling

    2015-01-01

    polymersomes Fe 3 O 4 /Cu 3 (BTC) 2 nanocomposites SAIO@SiObenzene- 1,3,5-tricarboxylate, BTC; iron oxide/silica core–

  3. Development of a Light Actuated Drug Delivery-on-Demand System

    E-Print Network [OSTI]

    Linsley, Chase Schilling

    2015-01-01

    blue causes a rapid phase transition in NiPAAm that resultsundergoes a rapid volume phase transition upon heating. Thea rapid, thermodynamically driven phase transition [16]. The

  4. COMPUTATIONAL STUDIES OF CONTROLLED NANOPARTICLE AGGLOMERATIONS FOR MRI-GUIDED NANOROBOTIC DRUG-DELIVERY SYSTEMS

    E-Print Network [OSTI]

    Mavroidis, Constantinos

    groups have employed magnetized micro/ nanoparticles and have implemented magnetic propulsion techniques implementation is difficult and medically invasive. Finally, magnetic propulsion techniques #12;other thanEastern University Boston, MA 02115 mavro@coe.neu.edu ABSTRACT Magnetic Resonance Imaging (MRI) guided nanorobotic

  5. Bioactive and bioresponsive nanoparticle surface modifications for vaccine and systemic drug delivery

    E-Print Network [OSTI]

    Clawson, Corbin Zean

    2011-01-01

    purchased from Alfa Aesar (Ward Hill, MA). Oleic acid waspurchased from Alfa Aesar (Ward Hill, MA). The bicinchoninic

  6. Telerobotic system concept for real-time soft-tissue imaging during radiotherapy beam delivery

    SciTech Connect (OSTI)

    Schlosser, Jeffrey; Salisbury, Kenneth; Hristov, Dimitre [Department of Mechanical Engineering, Stanford University, Stanford, California 94305 (United States); Department of Computer Science and Department of Surgery, Stanford University, Stanford, California 94305 (United States); Department of Radiation Oncology, Stanford University, Stanford, California 94305 (United States)

    2010-12-15

    Purpose: The curative potential of external beam radiation therapy is critically dependent on having the ability to accurately aim radiation beams at intended targets while avoiding surrounding healthy tissues. However, existing technologies are incapable of real-time, volumetric, soft-tissue imaging during radiation beam delivery, when accurate target tracking is most critical. The authors address this challenge in the development and evaluation of a novel, minimally interfering, telerobotic ultrasound (U.S.) imaging system that can be integrated with existing medical linear accelerators (LINACs) for therapy guidance. Methods: A customized human-safe robotic manipulator was designed and built to control the pressure and pitch of an abdominal U.S. transducer while avoiding LINAC gantry collisions. A haptic device was integrated to remotely control the robotic manipulator motion and U.S. image acquisition outside the LINAC room. The ability of the system to continuously maintain high quality prostate images was evaluated in volunteers over extended time periods. Treatment feasibility was assessed by comparing a clinically deployed prostate treatment plan to an alternative plan in which beam directions were restricted to sectors that did not interfere with the transabdominal U.S. transducer. To demonstrate imaging capability concurrent with delivery, robot performance and U.S. target tracking in a phantom were tested with a 15 MV radiation beam active. Results: Remote image acquisition and maintenance of image quality with the haptic interface was successfully demonstrated over 10 min periods in representative treatment setups of volunteers. Furthermore, the robot's ability to maintain a constant probe force and desired pitch angle was unaffected by the LINAC beam. For a representative prostate patient, the dose-volume histogram (DVH) for a plan with restricted sectors remained virtually identical to the DVH of a clinically deployed plan. With reduced margins, as would be enabled by real-time imaging, gross tumor volume coverage was identical while notable reductions of bladder and rectal volumes exposed to large doses were possible. The quality of U.S. images obtained during beam operation was not appreciably degraded by radiofrequency interference and 2D tracking of a phantom object in U.S. images obtained with the beam on/off yielded no significant differences. Conclusions: Remotely controlled robotic U.S. imaging is feasible in the radiotherapy environment and for the first time may offer real-time volumetric soft-tissue guidance concurrent with radiotherapy delivery.

  7. Design and optimization of a multi-particle accelerator beam transport and delivery system for material irradiation in nuclear and fusion science

    E-Print Network [OSTI]

    Sordelet, Tyler Christopher

    2012-01-01

    A beam delivery and transport system were designed for the use in MIT Materials Test Facility (M2TF). The purpose of this beam delivery system was to design a 36 MeV Proton Cyclotron for DPA accumulation and a 100 MeV ...

  8. Using the National Engineering Education Delivery System as the Foundation for Building a Test-Bed Digital Library for

    E-Print Network [OSTI]

    Agogino, Alice M.

    to developing a national digital library for SMET education that is much more than a static informationUsing the National Engineering Education Delivery System as the Foundation for Building a Test-Bed Digital Library for Science, Mathematics, Engineering and Technology Education Final Report for NSF Grant

  9. NGNP Data Management and Analysis System Analysis and Web Delivery Capabilities

    SciTech Connect (OSTI)

    Cynthia D. Gentillon

    2011-09-01

    Projects for the Very High Temperature Reactor (VHTR) Technology Development Office provide data in support of Nuclear Regulatory Commission licensing of the very high temperature reactor. Fuel and materials to be used in the reactor are tested and characterized to quantify performance in high-temperature and high-fluence environments. The NGNP Data Management and Analysis System (NDMAS) at the Idaho National Laboratory has been established to ensure that VHTR data are (1) qualified for use, (2) stored in a readily accessible electronic form, and (3) analyzed to extract useful results. This document focuses on the third NDMAS objective. It describes capabilities for displaying the data in meaningful ways and for data analysis to identify useful relationships among the measured quantities. The capabilities are described from the perspective of NDMAS users, starting with those who just view experimental data and analytical results on the INL NDMAS web portal. Web display and delivery capabilities are described in detail. Also the current web pages that show Advanced Gas Reactor, Advanced Graphite Capsule, and High Temperature Materials test results are itemized. Capabilities available to NDMAS developers are more extensive, and are described using a second series of examples. Much of the data analysis efforts focus on understanding how thermocouple measurements relate to simulated temperatures and other experimental parameters. Statistical control charts and correlation monitoring provide an ongoing assessment of instrument accuracy. Data analysis capabilities are virtually unlimited for those who use the NDMAS web data download capabilities and the analysis software of their choice. Overall, the NDMAS provides convenient data analysis and web delivery capabilities for studying a very large and rapidly increasing database of well-documented, pedigreed data.

  10. SU-E-T-107: Development of a GPU-Based Dose Delivery System for Adaptive Pencil Beam Scanning

    SciTech Connect (OSTI)

    Giordanengo, S; Russo, G; Marchetto, F; Attili, A; Monaco, V; Varasteh, M; Pella, A

    2014-06-01

    Purpose: A description of a GPU-based dose delivery system (G-DDS) to integrate a fast forward planning implementing in real-time the prescribed sequence of pencil beams. The system, which is under development, is designed to evaluate the dose distribution deviations due to range variations and interplay effects affecting mobile tumors treatments. Methods: The Dose Delivery System (DDS) in use at the Italian Centro Nazionale di Adroterapia Oncologica (CNAO), is the starting point for the presented system. A fast and partial forward planning (FP) tool has been developed to evaluate in few seconds the delivered dose distributions using the DDS data (on-line measurements of spot properties, i.e. number of particles and positions). The computation is performed during the intervals between synchrotron spills and, made available at the end of each spill. In the interval between two spills, the G-DDS will evaluate the delivered dose distributions taking into account the real-time target positions measured by a tracking system. The sequence of prescribed pencil beams for the following spill will be adapted taking into account the variations with respect to the original plan due to the target motion. In order to speed up the computation required to modify pencil beams distribution (up to 400 times has been reached), the Graphics Processing Units (GPUs) and advanced Field Programmable Gate Arrays (FPGAs) are used. Results: An existing offline forward planning is going to be optimized for the CUDA architecture: the gain in time will be presented. The preliminary performances of the developed GPU-based FP algorithms will be shown. Conclusion: A prototype of a GPU-based dose delivery system is under development and will be presented. The system workflow will be illustrated together with the approach adopted to integrate the three main systems, i.e. CNAO dose delivery system, fast forward planning, and tumor tracking system.

  11. A simple, rapid, and sensitive system for the evaluation of anti-viral drugs in rats

    SciTech Connect (OSTI)

    Li, Xiaoguang [Tohoku University Graduate School of Medicine, Department of Internal Medicine/Division of Emerging Infectious Diseases, Sendai 980-8575 (Japan) [Tohoku University Graduate School of Medicine, Department of Internal Medicine/Division of Emerging Infectious Diseases, Sendai 980-8575 (Japan); Department of Medical Microbiology, Harbin Medical University, Harbin 150086 (China); Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811 (Japan); Qian, Hua [Tohoku University Graduate School of Medicine, Department of Internal Medicine/Division of Emerging Infectious Diseases, Sendai 980-8575 (Japan) [Tohoku University Graduate School of Medicine, Department of Internal Medicine/Division of Emerging Infectious Diseases, Sendai 980-8575 (Japan); Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811 (Japan); Miyamoto, Fusako [Tohoku University Graduate School of Medicine, Department of Internal Medicine/Division of Emerging Infectious Diseases, Sendai 980-8575 (Japan)] [Tohoku University Graduate School of Medicine, Department of Internal Medicine/Division of Emerging Infectious Diseases, Sendai 980-8575 (Japan); Naito, Takeshi [Laboratory of Virus Control, Institute for Virus Research, Kyoto University, 53 Kawaramachi, Shogoin, Sakyo-ku, Kyoto 606-8507 (Japan)] [Laboratory of Virus Control, Institute for Virus Research, Kyoto University, 53 Kawaramachi, Shogoin, Sakyo-ku, Kyoto 606-8507 (Japan); Kawaji, Kumi [Tohoku University Graduate School of Medicine, Department of Internal Medicine/Division of Emerging Infectious Diseases, Sendai 980-8575 (Japan)] [Tohoku University Graduate School of Medicine, Department of Internal Medicine/Division of Emerging Infectious Diseases, Sendai 980-8575 (Japan); Kajiwara, Kazumi [Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501 (Japan) [Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501 (Japan); JST Innovation Plaza Kyoto, Japan Science and Technology Agency, Nishigyo-ku, Kyoto 615-8245 (Japan); Hattori, Toshio [Tohoku University Graduate School of Medicine, Department of Internal Medicine/Division of Emerging Infectious Diseases, Sendai 980-8575 (Japan)] [Tohoku University Graduate School of Medicine, Department of Internal Medicine/Division of Emerging Infectious Diseases, Sendai 980-8575 (Japan); Matsuoka, Masao [Laboratory of Virus Control, Institute for Virus Research, Kyoto University, 53 Kawaramachi, Shogoin, Sakyo-ku, Kyoto 606-8507 (Japan)] [Laboratory of Virus Control, Institute for Virus Research, Kyoto University, 53 Kawaramachi, Shogoin, Sakyo-ku, Kyoto 606-8507 (Japan); Watanabe, Kentaro; Oishi, Shinya; Fujii, Nobutaka [Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501 (Japan)] [Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501 (Japan); and others

    2012-07-27

    Highlights: Black-Right-Pointing-Pointer We established a novel, simple and rapid in vivo system for evaluation of anti-HIV-1 drugs with rats. Black-Right-Pointing-Pointer The system may be applicable for other antiviral drugs, and/or useful for initial screening in vivo. Black-Right-Pointing-Pointer In this system, TRI-1144 displayed the most potent anti-HIV-1 activity in vivo. -- Abstract: The lack of small animal models for the evaluation of anti-human immunodeficiency virus type 1 (HIV-1) agents hampers drug development. Here, we describe the establishment of a simple and rapid evaluation system in a rat model without animal infection facilities. After intraperitoneal administration of test drugs to rats, antiviral activity in the sera was examined by the MAGI assay. Recently developed inhibitors for HIV-1 entry, two CXCR4 antagonists, TF14016 and FC131, and four fusion inhibitors, T-20, T-20EK, SC29EK, and TRI-1144, were evaluated using HIV-1{sub IIIB} and HIV-1{sub BaL} as representative CXCR4- and CCR5-tropic HIV-1 strains, respectively. CXCR4 antagonists were shown to only possess anti-HIV-1{sub IIIB} activity, whereas fusion inhibitors showed both anti-HIV-1{sub IIIB} and anti-HIV-1{sub BaL} activities in rat sera. These results indicate that test drugs were successfully processed into the rat sera and could be detected by the MAGI assay. In this system, TRI-1144 showed the most potent and sustained antiviral activity. Sera from animals not administered drugs showed substantial anti-HIV-1 activity, indicating that relatively high dose or activity of the test drugs might be needed. In conclusion, the novel rat system established here, 'phenotypic drug evaluation', may be applicable for the evaluation of various antiviral drugs in vivo.

  12. A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA

    E-Print Network [OSTI]

    Liu, David V.

    Protein-based methods of targeted short-interfering RNA (siRNA) delivery have the potential to solve some of the problems faced by nanoparticle-based methods, such as poor pharmacokinetics and biodistribution, low tumor ...

  13. Implementation of a Project Management System for Improvement to City, State's Design and Construction Capital Project Delivery

    E-Print Network [OSTI]

    Thompson, Chad C.

    2007-05-18

    than 400 projects with budgets of over a half billion dollars. It has shifted the capital improvement project delivery from a “multi-departmental” style of delivery to a “project management” style of delivery through the infusion of private consultants...

  14. Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology

    E-Print Network [OSTI]

    Kalueff, Allan V.

    Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology Adam , Anna Minasyanb , Pentti Tuohimaab and Allan V. Kalueffa Vitamin D is becoming increasingly recognized metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive

  15. System Description for the K-25/K-27 D&D Project Polyurethane Foam Delivery System, East Tennessee Technology Park, Oak Ridge, Tennessee

    SciTech Connect (OSTI)

    Boris, G.

    2008-02-21

    The Foam Delivery System used in the decontamination and decommissioning (D&D) project for the K-25/K-27 Buildings at the East Tennessee Technology Park (ETTP) is comprised of a trailer-mounted Gusmer{reg_sign} H20/35 Pro-TEC Proportioning Unit and the associated equipment to convey electrical power, air, and foam component material to the unit. This high-pressure, plural-component polyurethane foam pouring system will be used to fill process gas and non-process equipment/piping (PGE/P) within the K-25/K-27 Buildings with polyurethane foam to immobilize contaminants prior to removal. The system creates foam by mixing isocyanate and polyol resin (Resin) component materials. Currently, the project plans to utilize up to six foaming units simultaneously during peak foaming activities. Also included in this system description are the foam component material storage containers that will be used for storage of the component material drums in a staging area outside of the K-25/K-27 Buildings. The Foam Delivery System and foam component material storage enclosures (i.e., Foaming Component Protective Enclosures) used to store polymeric methylene diphenyl diisocyanate (PMDI) component material are identified as Safety Significant (SS) Structures, Systems and Components (SSC) in the Documented Safety Analysis (DSA) for the project, Documented Safety Analysis for the K-25 and K-27 Facilities at the East Tennessee Technology Park, Oak Ridge, Tennessee, DSA-ET-K-25/K-27-0001.

  16. Lubricating system for thermal medium delivery parts in a gas turbine

    DOE Patents [OSTI]

    Mashey, Thomas Charles (Coxsackie, NY)

    2002-01-01

    Cooling steam delivery tubes extend axially along the outer rim of a gas turbine rotor for supplying cooling steam to and returning spent cooling steam from the turbine buckets. Because of the high friction forces at the interface of the tubes and supporting elements due to rotor rotation, a low coefficient of friction coating is provided at the interface of the tubes and support elements. On each surface, a first coating of a cobalt-based alloy is sprayed onto the surface at high temperature. A portion of the first coating is machined off to provide a smooth, hard surface. A second ceramic-based solid film lubricant is sprayed onto the first coating. By reducing the resistance to axial displacement of the tubes relative to the supporting elements due to thermal expansion, the service life of the tubes is substantially extended.

  17. Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug-

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug- Poly(Ocarboxyanhydride) Nanoconjugates Qian Yin, Rong Tong,, Yunxiang Xu, Kwanghyun Baek of polymer-drug conjugates for nanoparticulate drug delivery: hydroxyl-containing drug (e.g., camptothecin

  18. Safe and compact ammonia storage/delivery systems for SCR-DeNOX...

    Energy Savers [EERE]

    Safe and compact ammonia storagedelivery systems for SCR-DeNOX in automotive units Safe and compact ammonia storagedelivery systems for SCR-DeNOX in automotive units Presentation...

  19. A survey of commercially available manipulators, end-effectors, and delivery systems for reactor decommissioning activities

    SciTech Connect (OSTI)

    Henley, D.R.; Litka, T.J.

    1996-05-01

    Numerous nuclear facilities owned by the U.S. Department of Energy (DOE) are under consideration for decommissioning. Currently, there are no standardized, automated, remote systems designed to dismantle and thereby reduce the size of activated reactor components and vessels so that they can be packaged and shipped to disposal sites. Existing dismantling systems usually consist of customized, facility-specific tooling that has been developed to dismantle a specific reactor system. Such systems have a number of drawbacks. Generally, current systems cannot be disassembled, moved, and reused. Developing and deploying the tooling for current systems is expensive and time-consuming. In addition, the amount of manual work is significant because long-handled tools must be used; as a result, personnel are exposed to excessive radiation. A standardized, automated, remote system is therefore needed to deliver the tooling necessary to dismantle nuclear facilities at different locations. Because this system would be reusable, it would produce less waste. The system would also save money because of its universal design, and it would be more reliable than current systems.

  20. Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport

    E-Print Network [OSTI]

    Tang, Hua, 1972-

    2002-01-01

    Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

  1. The system for delivery of IR laser radiaton into high vacuum

    E-Print Network [OSTI]

    Abakumova, E V; Krasnov, A A; Muchnoi, N Yu; Pyata, E E

    2015-01-01

    The system for insertion of a laser beam into the vacuum chamber of high-energy storage ring is described. The main part of the system is the high-vacuum viewport for the IR radiation, based on ZnSe or GaAs crystals. The design of the viewports is presented.

  2. Digitally Fabricated Building Delivery

    E-Print Network [OSTI]

    Lab ­ Building Kit S 20 2Summer 2012 Integrated Systems ­ Programming Surfaces a) Exterior -Water production with integrated digital fabrication." Automation in Construction, Vol. 16, No. 3, 298­310, 2007Digitally Fabricated Building Delivery through Kitsthrough Kits Lawrence Sass Associate Professor

  3. Magnetically Triggered Nanocomposite Membranes: A Versatile Platform for Triggered Drug Release

    E-Print Network [OSTI]

    Hoare, Todd

    Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on?off drug release upon application (and removal) ...

  4. Chemical penetration enhancers and in situ-forming reservoirs for trans-tympanic drug delivery : progress toward improved treatment of Otitis media

    E-Print Network [OSTI]

    Simons, Emmanuel John

    2008-01-01

    Otitis media (OM) is the most common specifically-treated childhood disease in the United States. The widespread use of systemic antibiotics against a disease of such high incidence is believed to be a driving force behind ...

  5. Opportunistic sensing and mobile data delivery in the CarTel System

    E-Print Network [OSTI]

    Hull, Bret Warren, 1980-

    2010-01-01

    Wide-area sensor systems enable a broad class of applications, including the fine-grained monitoring of traffic congestion, road surface conditions, and pollution. This dissertation shows that it is possible to build a ...

  6. One System Integrated Project Team: Retrieval And Delivery Of The Hanford Tank Wastes For Vitrification In The Waste Treatment Plant

    SciTech Connect (OSTI)

    Harp, Benton J. [Department of Energy, Office of River Protection, Richland, Washington (United States); Kacich, Richard M. [Bechtel National, Inc., Richland, WA (United States); Skwarek, Raymond J. [Washington River Protection Solutions LLC, Richland, WA (United States)

    2012-12-20

    The One System Integrated Project Team (IPT) was formed in late 2011 as a way for improving the efficiency of delivery and treatment of highly radioactive waste stored in underground tanks at the U.S. Department of Energy's (DOE's) 586-square-mile Hanford Site in southeastern Washington State. The purpose of the One System IPT is to improve coordination and integration between the Hanford's Waste Treatment Plant (WTP) contractor and the Tank Operations Contractor (TOC). The vision statement is: One System is a WTP and TOC safety conscious team that, through integrated management and implementation of risk-informed decision and mission-based solutions, will enable the earliest start of safe and efficient treatment of Hanford's tank waste, to protect the Columbia River, environment and public. The IPT is a formal collaboration between Bechtel National, Inc. (BNI), which manages design and construction of the WTP for the U.S. Department of Energy's Office of River Protection (DOEORP), and Washington River Protection Solutions (WRPS), which manages the TOC for ORP. More than fifty-six (56) million gallons of highly radioactive liquid waste are stored in one hundred seventy-seven (177) aging, underground tanks. Most of Hanford's waste tanks - one hundred forty-nine (149) of them - are of an old single-shell tank (SST) design built between 1944 and 1964. More than sixty (60) of these tanks have leaked in the past, releasing an estimated one million gallons of waste into the soil and threatening the nearby Columbia River. There are another twenty-eight (28) new double-shelled tanks (DSTs), built from 1968 to 1986, that provide greater protection to the environment. In 1989, DOE, the U.S. Environmental Protection Agency (EPA), and the Washington State Department of Ecology (Ecology) signed a landmark agreement that required Hanford to comply with federal and state environmental standards. It also paved the way for agreements that set deadlines for retrieving the tank wastes and for building and operating the WTP. The tank wastes are the result of Hanford's nearly fifty (50) years of plutonium production. In the intervening years, waste characteristics have been increasingly better understood. However, waste characteristics that are uncertain and will remain as such represent a significant technical challenge in terms of retrieval, transport, and treatment, as well as for design and construction ofWTP. What also is clear is that the longer the waste remains in the tanks, the greater the risk to the environment and the people of the Pacific Northwest. The goal of both projects - tank operations and waste treatment - is to diminish the risks posed by the waste in the tanks at the earliest possible date. About two hundred (200) WTP and TOC employees comprise the IPT. Individual work groups within One System include Technical, Project Integration & Controls, Front-End Design & Project Definition, Commissioning, Nuclear Safety & Engineering Systems Integration, and Environmental Safety and Health and Quality Assurance (ESH&QA). Additional functions and team members will be added as the WTP approaches the operational phase. The team has undertaken several initiatives since its formation to collaborate on issues: (1) alternate scenarios for delivery of wastes from the tank farms to WTP; (2) improvements in managing Interface Control Documents; (3) coordination on various technical issues, including the Defense Nuclear Facilities Nuclear Safety Board's Recommendation 2010-2; (4) deployment of the SmartPlant? Foundation-configuration Management System; and (5) preparation of the joint contract deliverable of the Operational Readiness Support Plan.

  7. Time-Resolved SAXS/WAXS Study of the Phase Behavior and Microstructural Evolution of Drug/PEG Solid Dispersions

    SciTech Connect (OSTI)

    Zhu, Qing; Harris, Michael T.; Taylor, Lynne S. (Purdue)

    2013-03-07

    Simultaneous small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS) was employed to elucidate the physical state and location of various small molecule drugs blended with polyethylene glycol (PEG), as well as the time dependent microstructural evolution of the systems. Samples were prepared by comelting physical mixtures of the drug and PEG, followed by solidification at 25 C. The model drugs selected encompassed a wide variety of physicochemical properties in terms of crystallization tendency and potential for interaction with PEG. It was observed that compounds which crystallized rapidly and had weak interactions with PEG tended to be excluded from the interlamellar region of the PEG matrix. In contrast, drugs which had favorable interactions with PEG were incorporated into the interlamellar regions of the polymer up until the point at which the drug crystallized whereby phase separation occurred. These factors are likely to impact the effectiveness of drug/PEG systems as drug delivery systems.

  8. Nonviral Vectors for Gene Delivery

    E-Print Network [OSTI]

    Baoum, Abdulgader Ahmed

    2011-04-26

    , two nonviral gene delivery systems using either biodegradable poly(D,L-lactide-co-glycolide) (PLG) nanoparticles or cell penetrating peptide (CPP) complexes have been designed and studied using A549 human lung epithelial cells. PLG nanoparticles were...

  9. Solar concentrator with integrated tracking and light delivery system with summation

    DOE Patents [OSTI]

    Maxey, Lonnie Curt

    2015-05-05

    A solar light distribution system includes a solar light concentrator that is affixed externally to a light transfer tube. Solar light waves are processed by the concentrator into a collimated beam of light, which is then transferred through a light receiving port and into the light transfer tube. A reflector redirects the collimated beam of light through the tube to a light distribution port. The interior surface of the light transfer tube is highly reflective so that the light transfers through the tube with minimal losses. An interchangeable luminaire is attached to the light distribution port and provides light inside of a structure. A sun tracking device rotates the concentrator and the light transfer tube to optimize the receiving of solar light by the concentrator throughout the day. The system provides interior lighting that uses only renewable energy sources, and releases no carbon dioxide emissions into the atmosphere.

  10. Solar concentrator with integrated tracking and light delivery system with collimation

    DOE Patents [OSTI]

    Maxey, Lonnie Curt

    2015-06-09

    A solar light distribution system includes a solar light concentrator that is affixed externally to a light transfer tube. Solar light waves are processed by the concentrator into a collimated beam of light, which is then transferred through a light receiving port and into the light transfer tube. A reflector directs the collimated beam of light through the tube to a light distribution port. The interior surface of the light transfer tube is highly reflective so that the light transfers through the tube with minimal losses. An interchangeable luminaire is attached to the light distribution port and distributes light inside of a structure. A sun tracking device rotates the concentrator and the light transfer tube to optimize the receiving of solar light by the concentrator throughout the day. The system provides interior lighting, uses only renewable energy sources, and releases no carbon dioxide emissions into the atmosphere.

  11. Bushing retention system for thermal medium cooling delivery tubes in a gas turbine rotor

    DOE Patents [OSTI]

    Mashey, Thomas Charles (Coxsackie, NY)

    2002-01-01

    Bushings are provided in counterbores for wheels and spacers for supporting thermal medium cooling tubes extending axially adjacent the rim of the gas turbine rotor. The retention system includes a retaining ring disposed in a groove adjacent an end face of the bushing and which retaining ring projects radially inwardly to prevent axial movement of the bushing in one direction. The retention ring has a plurality of circumferentially spaced tabs along its inner diameter whereby the ring is supported by the lands of the tube maintaining its bushing retention function, notwithstanding operation in high centrifugal fields and rotation of the ring in the groove into other circular orientations.

  12. Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative Loading Efficiency

    E-Print Network [OSTI]

    Cheng, Jianjun

    Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative LoadingChampaign, Urbana, Illinois 61801, United States Key Laboratory of Smart Drug Delivery, Ministry of Education-molecule drugs in hydrophobic polymers or amphiphilic copolymers has been extensively used for preparing

  13. Experimenting with Drugs (and Topic Models): Multi-Dimensional Exploration of Recreational Drug Discussions

    E-Print Network [OSTI]

    Dredze, Mark

    Experimenting with Drugs (and Topic Models): Multi-Dimensional Exploration of Recreational Drug of new recreational drugs and trends re- quires mining current information from non-traditional text components. The resulting model learns factors that correspond to drug type, delivery method (smoking

  14. NGNP Data Management and Analysis System Analysis and Web Delivery Capabilities

    SciTech Connect (OSTI)

    Cynthia D. Gentillon

    2010-09-01

    Projects for the Very High Temperature Reactor Technology Development Office provide data in support of Nuclear Regulatory Commission licensing of the very high temperature reactor. Fuel and materials to be used in the reactor are tested and characterized to quantify performance in high-temperature and high-fluence environments. In addition, thermal-hydraulic experiments are conducted to validate codes used to assess reactor safety. The Very High Temperature Reactor Technology Development Office has established the NGNP Data Management and Analysis System (NDMAS) at the Idaho National Laboratory to ensure that very high temperature reactor data are (1) qualified for use, (2) stored in a readily accessible electronic form, and (3) analyzed to extract useful results. This document focuses on the third NDMAS objective. It describes capabilities for displaying the data in meaningful ways and for data analysis to identify useful relationships among the measured quantities.

  15. SU-E-T-407: Evaluation of Four Commercial Dosimetry Systems for Routine Patient-Specific Tomotherapy Delivery Quality Assurance

    SciTech Connect (OSTI)

    Xing, A; Arumugam, S; Deshpande, S; George, A; Holloway, L; Vial, P; Goozee, G [Liverpool Cancer Therapy Centre, Sydney, NSW (Australia)

    2014-06-01

    Purpose: The purpose of this project was to evaluate the performance of four commercially available dosimetry systems for Tomotherapy delivery quality assurance (DQA). Methods: Eight clinical patient plans were chosen to represent a range of treatment sites and typical clinical plans. Four DQA plans for each patient plan were created using the TomoTherapy DQA Station (Hi-Art version 4.2.1) on CT images of the ScandiDose Delta4, IBA MatriXX Evolution, PTW Octavius 4D and Sun Nuclear ArcCHECK phantoms. Each detector was calibrated following the manufacture-provided procedure. No angular response correction was applied. All DQA plans for each detector were delivered on the Tomotherapy Hi-Art unit in a single measurement session but on different days. The measured results were loaded into the vendor supplied software for each QA system for comparison with the TPS-calculated dose. The Gamma index was calculated using 3%/3mm, 2%/2mm with 10% dose threshold of maximum TPS calculated dose. Results: Four detector systems showed comparable gamma pass rates for 3%/3m, which is recommended by AAPM TG119 and commonly used within the radiotherapy community. The averaged pass rates ± standard deviation for all DQA plans were (98.35±1.97)% for ArcCHECK, (99.9%±0.87)% for Matrix, (98.5%±5.09)% for Octavius 4D, (98.7%±1.27)% for Delata4. The rank of the gamma pass rate for individual plans was consistent between detectors. Using 2%/2mm Gamma criteria for analysis, the Gamma pass rate decreased on average by 9%, 8%, 6.6% and 5% respectively. Profile and Gamma failure map analysis using the software tools from each dosimetry system indicated that decreased passing rate is mainly due to the threading effect of Tomo plan. Conclusion: Despite the variation in detector type and resolution, phantom geometry and software implementation, the four systems demonstrated similar dosimetric performance, with the rank of the gamma pass rate consistent for the plans considered.

  16. X-Band Crab Cavities for the CLIC Beam Delivery System

    SciTech Connect (OSTI)

    Burt, G.; Ambattu, P.K.; Dexter, A.C.; Abram, T.; Dolgashev, V.; Tantawi, S.; Jones, R.M.; /Cockcroft Inst. Accel. Sci. Tech. /Manchester U.

    2011-11-22

    The CLIC machine incorporates a 20 mrad crossing angle at the IP to aid the extraction of spent beams. In order to recover the luminosity lost through the crossing angle a crab cavity is proposed to rotate the bunches prior to collision. The crab cavity is chosen to have the same frequency as the main linac (11.9942 GHz) as a compromise between size, phase stability requirements and beam loading. It is proposed to use a HE11 mode travelling wave structure as the CLIC crab cavity in order to minimise beam loading and mode separation. The position of the crab cavity close to the final focus enhances the effect of transverse wake-fields so effective wake-field damping is required. A damped detuned structure is proposed to suppress and de-cohere the wake-field hence reducing their effect. Design considerations for the CLIC crab cavity will be discussed as well as the proposed high power testing of these structures at SLAC. Design of a crab cavity for CLIC is underway at the Cockcroft Institute in collaboration with SLAC. This effort draws on a large degree of synergy with the ILC crab cavity developed at the Cockcroft Institute and other deflecting structure development at SLAC. A study of phase and amplitude variations in the cavity suggests that the tolerances are very tight and require a 'beyond state of the art' LLRF control system. A study of cavity geometry and its effect on the cavity fields has been performed using Microwave studio. This study has suggested that for our cavity an iris radius between 4-5 mm is optimum with an iris thickness of 2-3 mm based on group velocity and peak fields. A study of the cavity wakefields show that the single bunch wakes are unlikely to be a problem but the short bunch spacing may cause the multi-bunch wakefields to be an issue. This will require some of the modes to be damped strongly so that the wake is damped significantly before any following bunch arrives. Various methods of damping have been investigated and suggest that waveguide damping in the cells should provide sufficient damping in the vertical plane, which is the most sensitive.

  17. Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2007-01-01

    Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

  18. Physicochemical investigations of a drug delivery oscillator

    E-Print Network [OSTI]

    Bhalla, A. S.; Siegel, R. A.

    2006-10-27

    .8 5.3 0 0.2 0.4 0.6 0.8 1 1.2 1.4 Volume of 0.009 N HCl added (mL) p H 0.178 0.704 1.146 1.77 2.158 2.77 3.69 4.04 4.68 5.69 6.77 0 Days Buffer capacity increases with time Fit 4.3 4.5 4.7 4.9 5.1 5.3 5.5 0 10 20 30 40 50 60 70 80 90 Time (Hours) p H...-isopropylacrylamide (NIPA) Hydrophobic at 370 C 90 mol % or 95 mol % Ethyleneglycoldimethacrylate (EGDMA) Crosslinker Methacrylic acid (MAA) pKa =4.66 Hydrophilic in basic form 10 mol % or 5 mol% COO - COO - COO --COO - ? Gluconic acid/gluconate buffer build up...

  19. Nanodisk: a versatile drug delivery platform

    E-Print Network [OSTI]

    Ghosh, Mistuni

    2012-01-01

    of curcumin and resveratrol in combination reduces prostateof curcumin and resveratrol in combination reduces prostate

  20. Assessment of Available Particle Size Data to Support an Analysis of the Waste Feed Delivery System Transfer System

    SciTech Connect (OSTI)

    JEWETT, J.R.

    2000-08-10

    Available data pertaining to size distribution of the particulates in Hanford underground tank waste have been reviewed. Although considerable differences exist between measurement methods, it may be stated with 95% confidence that the median particle size does not exceed 275 {micro}m in at least 95% of the ten tanks selected as sources of HLW feed for Phase 1 vitrification in the RPP. This particle size is recommended as a design basis for the WFD transfer system.

  1. Self-assembled pentablock copolymers for selective and sustained gene delivery

    SciTech Connect (OSTI)

    Zhang, Bingqi

    2011-05-15

    The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

  2. Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    Abstract Insulin-loaded polymer (ILP) microparticles composed of poly(methacrylic acid) and poly(ethylene-release mechanisms for their abilities to shield drug molecules from degradation in the stom- ach and the upper

  3. "...powered bodies turn to commodities..." -stereolab Drugs and Drug Abuse

    E-Print Network [OSTI]

    Teissére, Jeremy Alden

    "...powered bodies turn to commodities..." - stereolab BIO 115 Fall, 2008 Drugs and Drug Abuse the current narratives surrounding drug use. In parallel, we will closely examine the putative mechanisms by which drugs act in the central nervous system ­ and also discuss how the action of these drugs has

  4. Hydrogen delivery technology roadmap

    SciTech Connect (OSTI)

    None, None

    2005-11-15

    Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

  5. Antiarrhythmic Drugs

    E-Print Network [OSTI]

    Abbott, GW; Levi, R

    2012-01-01

    of beta blockers: from antianginal drugs to ligand-directedmechanisms of gating and drug block of sodium channels.Roden DM. Antiarrhythmic drugs: past, present and future. J

  6. Macro-System Model: A Federated Object Model for Cross-Cutting Analysis of Hydrogen Production, Delivery, Consumption and Associated Emissions; Preprint

    SciTech Connect (OSTI)

    Ruth, M.; Diakov, V.; Goldsby, M. E.; Sa, T. J.

    2010-12-01

    It is commonly accepted that the introduction of hydrogen as an energy carrier for light-duty vehicles involves concomitant technological development of infrastructure elements, such as production, delivery, and consumption, all associated with certain emission levels. To analyze these at a system level, the suite of corresponding models developed by the United States Department of Energy and involving several national laboratories is combined in one macro-system model (MSM). The macro-system model is being developed as a cross-cutting analysis tool that combines a set of hydrogen technology analysis models. Within the MSM, a federated simulation framework is used for consistent data transfer between the component models. The framework is built to suit cross-model as well as cross-platform data exchange and involves features of 'over-the-net' computation.

  7. Lipid Bilayer-Coated Curcumin-based Mesoporous Organosilica Nanoparticles for Cellular Delivery

    E-Print Network [OSTI]

    Stefan Datz; Hanna Engelke; Constantin v. Schirnding; Linh Nguyen; Thomas Bein

    2015-09-08

    Effective and controlled drug delivery systems with on-demand release abilities and biocompatible properties receive enormous attention for biomedical applications. Here, we describe a novel inorganic-organic hybrid material with a strikingly high organic content of almost 50 wt%. The colloidal periodic mesoporous organosilica (PMO) nanoparticles synthesized in this work consist entirely of curcumin and ethane derivatives serving as constituents that are crosslinked by siloxane bridges, without any added silica. These mesoporous curcumin nanoparticles (MCNs) exhibit very high surface areas (over 1000 m2/g), narrow particle size distribution (around 200 nm) and a strikingly high stability in simulated biological media. Additionally, the MCNs are used as a cargo delivery system in live-cell experiments. A supported lipid bilayer (SLB) efficiently seals the pores and releases Rhodamin B as model cargo in HeLa cells. This novel nanocarrier concept provides a promising platform for the development of controllable and highly biocompatible theranostic systems.

  8. Articulating feedstock delivery device

    DOE Patents [OSTI]

    Jordan, Kevin

    2013-11-05

    A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

  9. Lipid Bilayer-Coated Curcumin-based Mesoporous Organosilica Nanoparticles for Cellular Delivery

    E-Print Network [OSTI]

    Datz, Stefan; Schirnding, Constantin v; Nguyen, Linh; Bein, Thomas

    2015-01-01

    Effective and controlled drug delivery systems with on-demand release abilities and biocompatible properties receive enormous attention for biomedical applications. Here, we describe a novel inorganic-organic hybrid material with a strikingly high organic content of almost 50 wt%. The colloidal periodic mesoporous organosilica (PMO) nanoparticles synthesized in this work consist entirely of curcumin and ethane derivatives serving as constituents that are crosslinked by siloxane bridges, without any added silica. These mesoporous curcumin nanoparticles (MCNs) exhibit very high surface areas (over 1000 m2/g), narrow particle size distribution (around 200 nm) and a strikingly high stability in simulated biological media. Additionally, the MCNs are used as a cargo delivery system in live-cell experiments. A supported lipid bilayer (SLB) efficiently seals the pores and releases Rhodamin B as model cargo in HeLa cells. This novel nanocarrier concept provides a promising platform for the development of controllable ...

  10. Tools for integrating diagnosis in the design process An application to the Common Rail air and fuel delivery systems

    E-Print Network [OSTI]

    in current generation automotive systems. However, the activities related to diagnosis (e.g., FMEA generation such as the diagnosability of the system being designed or the analysis of the FMEA (Failure Modes and Effects Analysis

  11. 912 IEEE TRANSACTIONS ON POWER DELIVERY, VOL. 19, NO. 3, JULY 2004 Robotic Monitoring of Power Systems

    E-Print Network [OSTI]

    Mamishev, Alexander

    --Monitoring of electric power systems in real time for reliability, aging status, and presence of incipient faults. INTRODUCTION ECONOMICALLY effective maintenance and monitoring of power systems to ensure high quality focuses on one trend of power system monitoring, namely, mobile monitoring. The developments in robotic

  12. Main chain acid-degradable polymers for the delivery of bioactive materials

    DOE Patents [OSTI]

    Frechet, Jean M. J. (Oakland, CA); Standley, Stephany M. (Evanston, IL); Jain, Rachna (Milpitas, CA); Lee, Cameron C. (Cambridge, MA)

    2012-03-20

    Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.

  13. Design of a cost-effective cookie feeding and delivery system on an automated robotic packaging manufacturing line

    E-Print Network [OSTI]

    Srivastava, Gita

    2007-01-01

    In order to transition to an efficient and automated cookie packaging line at the Gamesa-Quaker plant in Monterrey, Mexico, the goal of this project was to design an improved system to feed individual cookie packages to ...

  14. An Environment Aware P-System Model of Quorum Sensing

    E-Print Network [OSTI]

    Krasnogor, Natalio

    , and to program them as "nano-bots" for particular tasks such as targeted drug delivery, chemical factories, nano

  15. An Environment Aware P-System Model of Quorum Sensing

    E-Print Network [OSTI]

    Gheorghe, Marian

    , actuators, etc, and to program them as "nano-bots" for particular tasks such as targeted drug delivery

  16. Development of a polylactic acid (PLA) polymer with an acid-sensitive N-ethoxybenzylimidazole (NEBI) crosslinker as a drug delivery system

    E-Print Network [OSTI]

    Hang, Leibniz Fangtinq

    2012-01-01

    propargyl bromide with ethyl glyoxylate. A slurry of zinc (bromide (80% by weight in toluene, 450 ?L, 4.04 mmol) was added to the reaction flask to activate the zinc.

  17. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

    E-Print Network [OSTI]

    Chauhan, Vikash P.

    The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...

  18. Asynchronous broadcast for ordered delivery between compute nodes in a parallel computing system where packet header space is limited

    DOE Patents [OSTI]

    Kumar, Sameer

    2010-06-15

    Disclosed is a mechanism on receiving processors in a parallel computing system for providing order to data packets received from a broadcast call and to distinguish data packets received at nodes from several incoming asynchronous broadcast messages where header space is limited. In the present invention, processors at lower leafs of a tree do not need to obtain a broadcast message by directly accessing the data in a root processor's buffer. Instead, each subsequent intermediate node's rank id information is squeezed into the software header of packet headers. In turn, the entire broadcast message is not transferred from the root processor to each processor in a communicator but instead is replicated on several intermediate nodes which then replicated the message to nodes in lower leafs. Hence, the intermediate compute nodes become "virtual root compute nodes" for the purpose of replicating the broadcast message to lower levels of a tree.

  19. TBCAS-2010-Jun-0051-ISSCC-2010 1 Abstract--A fundamental problem that miniaturized systems

    E-Print Network [OSTI]

    Rincon-Mora, Gabriel A.

    source into a battery directly. In doing so, the circuit also increases the system's electrical damping implant, body-sensor network, battery charger, rectifier-free, harvester, switched-inductor converter. I. PIEZOELECTRIC ENERGY HARVESTERS INATURIZED mobile electronic systems, such as biomedical drug-delivery implants

  20. Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals

    DOE Patents [OSTI]

    Gardner, Shea Nicole (San Leandro, CA)

    2007-10-23

    A method and system for tailoring treatment regimens to individual patients with diseased cells exhibiting evolution of resistance to such treatments. A mathematical model is provided which models rates of population change of proliferating and quiescent diseased cells using cell kinetics and evolution of resistance of the diseased cells, and pharmacokinetic and pharmacodynamic models. Cell kinetic parameters are obtained from an individual patient and applied to the mathematical model to solve for a plurality of treatment regimens, each having a quantitative efficacy value associated therewith. A treatment regimen may then be selected from the plurlaity of treatment options based on the efficacy value.

  1. Lipidoid-Coated Iron Oxide Nanoparticles for Efficient DNA and siRNA delivery

    E-Print Network [OSTI]

    Jiang, Shan

    The safe, targeted and effective delivery of gene therapeutics remains a significant barrier to their broad clinical application. Here we develop a magnetic nucleic acid delivery system composed of iron oxide nanoparticles ...

  2. Measurements of lateral penumbra for uniform scanning proton beams under various beam delivery conditions and comparison to the XiO treatment planning system

    SciTech Connect (OSTI)

    Rana, Suresh; Zeidan, Omar; Ramirez, Eric; Rains, Michael; Gao, Junfang; Zheng, Yuanshui [Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, Oklahoma 73142 (United States)] [Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, Oklahoma 73142 (United States)

    2013-09-15

    Purpose: The main purposes of this study were to (1) investigate the dependency of lateral penumbra (80%–20% distance) of uniform scanning proton beams on various factors such as air gap, proton range, modulation width, compensator thickness, and depth, and (2) compare the lateral penumbra calculated by a treatment planning system (TPS) with measurements.Methods: First, lateral penumbra was measured using solid–water phantom and radiographic films for (a) air gap, ranged from 0 to 35 cm, (b) proton range, ranged from 8 to 30 cm, (c) modulation, ranged from 2 to 10 cm, (d) compensator thickness, ranged from 0 to 20 cm, and (e) depth, ranged from 7 to 15 cm. Second, dose calculations were computed in a virtual water phantom using the XiO TPS with pencil beam algorithm for identical beam conditions and geometrical configurations that were used for the measurements. The calculated lateral penumbra was then compared with the measured one for both the horizontal and vertical scanning magnets of our uniform scanning proton beam delivery system.Results: The results in the current study showed that the lateral penumbra of horizontal scanning magnet was larger (up to 1.4 mm for measurement and up to 1.0 mm for TPS) compared to that of vertical scanning magnet. Both the TPS and measurements showed an almost linear increase in lateral penumbra with increasing air gap as it produced the greatest effect on lateral penumbra. Lateral penumbra was dependent on the depth and proton range. Specifically, the width of lateral penumbra was found to be always lower at shallower depth than at deeper depth within the spread out Bragg peak (SOBP) region. The lateral penumbra results were less sensitive to the variation in the thickness of compensator, whereas lateral penumbra was independent of modulation. Overall, the comparison between the results of TPS with that of measurements indicates a good agreement for lateral penumbra, with TPS predicting higher values compared to measurements.Conclusions: Lateral penumbra of uniform scanning proton beams depends on air gap, proton range, compensator thickness, and depth, whereas lateral penumbra is not dependent on modulation. The XiO TPS typically overpredicted lateral penumbra compared to measurements, within 1 mm for most cases, but the difference could be up to 2.5 mm at a deep depth and large air gap.

  3. Gaseous Hydrogen Delivery Breakout- Strategic Directions for Hydrogen Delivery Workshop

    Broader source: Energy.gov [DOE]

    Targets, barriers and research and development priorities for gaseous delivery of hydrogen through hydrogen and natural gas pipelines.

  4. Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast.

    E-Print Network [OSTI]

    Lanthaler, Karin; Bilsland, Elizabeth; Dobson, Paul D; Moss, Harry J; Pir, Pinar; Kell, Douglas B; Oliver, Stephen G

    2011-10-24

    -mediated raises the question of which drugs use which carriers. Results To answer this, we have constructed a chemical genomics platform built upon the yeast gene deletion collection, using competition experiments in batch fermenters and robotic automation...

  5. Discovering the Targets of Drugs Via Computational

    E-Print Network [OSTI]

    Discovering the Targets of Drugs Via Computational Systems Biology* Published, JBC Papers in Press is empowering the study of drug action. Studies on biological effects of chemical com- pounds have increased of drugs, with the collective potential to change the nature of drug discovery and pharmacological therapy

  6. LIFE Economics and Delivery Pathway Presentation to

    E-Print Network [OSTI]

    LIFE Economics and Delivery Pathway Presentation to National Research Council's review is necessary (but not sufficient) for economic viability Minimumforeconomics Cost and risk to buy additional systems approach is required to develop an economically viable plant design Anklam--NAS/NAE, January 29

  7. MFRC Training Development & Delivery Program - Bloodstain & Toxicology...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MFRC Training Development & Delivery Program - Bloodstain & Toxicology DESCRIPTION: The Midwest Forensics Resource Center (MFRC) Training Development and Delivery Program increases...

  8. Categorical Exclusion Determinations: Office of Electricity Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Office of Electricity Delivery and Energy Reliability Categorical Exclusion Determinations: Office of Electricity Delivery and Energy Reliability Categorical Exclusion...

  9. Apatite-Polymer Composites for the Controlled Dual Delivery of BMP-2 and BMP-6 for Bone Tissue Engineering

    E-Print Network [OSTI]

    Yong, Tseh-Hwan

    The release of growth factors from tissue engineering scaffolds provides signals that influence the migration, differentiation, and proliferation of cells. The incorporation of a drug delivery platform that is capable of ...

  10. Office of Electricity Delivery

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested Parties -DepartmentAvailableHigh SpatialElectricity Delivery and Energy

  11. Interfacial kinetics effects on transdermal drug delivery: a computer modeling

    E-Print Network [OSTI]

    Pan, Ning

    agents, which may not function well in the gastrointestinal tract or liver due to presystemic metabolism of the diffusion coefficient and the concentration gradient; here it is J ¼ ÀDij dCi dx ð1Þ where Dij is the binary

  12. Titanium MEMS Technology Development for Drug Delivery and Microfluidic Applications

    E-Print Network [OSTI]

    Khandan, Omid

    2015-01-01

    working in the UCSB cleanroom; it was challenging, but yourprocessing substrates in a cleanroom facility with micron-was conducted at the cleanroom solvent bench with exhaust

  13. Titanium MEMS Technology Development for Drug Delivery and Microfluidic Applications

    E-Print Network [OSTI]

    Khandan, Omid

    2015-01-01

    and D Tryk. 2008. “TiO2 Photocatalysis and Related SurfaceGünter Kreisel. 2004. “Photocatalysis in Microreactors. ”microfluidic devices for photocatalysis applications. As for

  14. Active scaffolds for on-demand drug and cell delivery

    E-Print Network [OSTI]

    Zhao, Xuanhe

    Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, ...

  15. Applications of triazine chemistry: education, remediation, and drug delivery 

    E-Print Network [OSTI]

    Hatfield, Susan Elizabeth

    2009-05-15

    (S N Ar). It may be used as an analogous acid chloride equivalent in many organic transformations, including chlorination, dehydration, and coupling reactions. 9-12 Table 1 summarizes some of the reactions in which trichlorotriazine may be used.... Table 1. Reactions using cyanuric chloride as a reagent Reactant Product R?CO?OH R?CO?Cl R 1 R 2 ?CH?OH R 1 R 2 ?CH?Cl R?CH=N?OH R?C?N HO?(CH 2 ) n ?COOH 7 Cyanuric chloride can also be used as an oxidizing agent using Swern oxidation...

  16. Functionalization of nanocarriers for efficient combination drug delivery

    E-Print Network [OSTI]

    Hu, Che-Ming Jack

    2011-01-01

    pentanedione (Alfa Aesar Co. , Ward Hill, MA) were used as~330 Da; Alfa Aesar, Ward Hill, MA), carboxyl-terminated

  17. Amorphous metal-organic frameworks for drug delivery

    E-Print Network [OSTI]

    Orellana-Tavra, Claudia; Baxter, Emma F.; Tian, Tian; Bennett, Thomas D.; Slater, Nigel K. H.; Cheetham, Anthony K.; Fairen-Jimenez, David

    2015-07-21

    , and a decrease in toxic side effects. Finding an effective DDS for therapeutic agents has been an ongoing challenge in bioengineering. In this context, metal-organic frameworks (MOFs) have emerged as potential candidates owing to their distinctive...

  18. Artificial Cells for Advanced Drug Delivery - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O O DBiomass and Biofuels Biomass and Biofuels Find More Like

  19. Molecule Nanoweaver Improves Drug Delivery and Treatment Efficacy - Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines light on77 PAGEMissionStress MolecularMolecular-Frame AngularCapsules

  20. Non-destructively shattered mesoporous silica for protein drug delivery

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTech Connect Nanomechanical switch for|Connect Non-Large Hadron Collider(Journal

  1. Hydrogen Delivery Roadmap

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancingR Walls -Hydro-Pac Inc., A High HydrogenInvitedDelivery

  2. Electro-osmotically driven liquid delivery method and apparatus

    DOE Patents [OSTI]

    Rakestraw, David J. (Fremont, CA); Anex, Deon S. (Livermore, CA); Yan, Chao (Pleasanton, CA); Dadoo, Rajeev (Stanford, CA); Zare, Richard N. (Stanford, CA)

    1999-01-01

    Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.

  3. Electro-osmotically driven liquid delivery method and apparatus

    DOE Patents [OSTI]

    Rakestraw, D.J.; Anex, D.S.; Yan, C.; Dadoo, R.; Zare, R.N.

    1999-08-24

    Method and apparatus are disclosed for controlling precisely the composition and delivery of liquid at sub-{micro}L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-{micro}L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column. 4 figs.

  4. Delivery of neuroactive peptide drugs to the brain via intranasal delivery

    E-Print Network [OSTI]

    Cros, C. D.; Toth, I.; Blanchfield, J.

    2006-10-27

    presents a human plasma stability assay on a racemic lipoamino acid Leu-enkephalin derivative. Methods Caco-2 Permeability assay: Caco-2 cells form tight monolayer structures when seeded on to polycarbonate filters. To assess permeability, a 200 ?M... is the initial concentration in the donor chamber. Plasma stability assay: This assay was performed by mixing 300?L of a solution of C8Laa- Enkephalin (1mg/mL) with 300?L of plasma prewarmed at 37.5????C. At chosen time points, 50?L of the plasma mixture...

  5. Hydrogen Distribution and Delivery Infrastructure

    SciTech Connect (OSTI)

    2008-11-01

    This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challenges to delivering hydrogen for use as a widespread energy carrier, and the research goals for hydrogen delivery.

  6. Hydrogen Delivery Technical Team Roadmap

    SciTech Connect (OSTI)

    2013-06-01

    The mission of the Hydrogen Delivery Technical Team (HDTT) is to enable the development of hydrogen delivery technologies, which will allow for fuel cell competitiveness with gasoline and hybrid technologies by achieving an as-produced, delivered, and dispensed hydrogen cost of $2-$4 per gallon of gasoline equivalent of hydrogen.

  7. A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

    E-Print Network [OSTI]

    Shao, Wei; Paul, Arghya; Abbasi, Sana; Chahal, Parminder S.; Mena, Jimmy A.; Montes, Johnny; Kamen, Amine; Prakash, Satya

    2012-01-01

    Systemic delivery of small interfering RNA (siRNA) is limited by its poor stability and limited cell-penetrating properties. To overcome these limitations, we designed an efficient siRNA delivery system using polyethylen ...

  8. Liquid Hydrogen Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Liquid Hydrogen Delivery Liquid Hydrogen Delivery Hydrogen is most commonly transported and delivered as a liquid when high-volume transport is needed in the absence of pipelines....

  9. Gaseous Hydrogen Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Gaseous Hydrogen Delivery Gaseous Hydrogen Delivery Gaseous hydrogen is most commonly delivered either by trucks or through pipelines. Because gaseous hydrogen is typically...

  10. Hydraulic Hybrid Parcel Delivery Truck Deployment, Testing & Demonstration

    SciTech Connect (OSTI)

    Gallo, Jean-Baptiste

    2014-03-07

    Although hydraulic hybrid systems have shown promise over the last few years, commercial deployment of these systems has primarily been limited to Class 8 refuse trucks. In 2005, the Hybrid Truck Users Forum initiated the Parcel Delivery Working Group including the largest parcel delivery fleets in North America. The goal of the working group was to evaluate and accelerate commercialization of hydraulic hybrid technology for parcel delivery vehicles. FedEx Ground, Purolator and United Parcel Service (UPS) took delivery of the world’s first commercially available hydraulic hybrid parcel delivery trucks in early 2012. The vehicle chassis includes a Parker Hannifin hydraulic hybrid drive system, integrated and assembled by Freightliner Custom Chassis Corp., with a body installed by Morgan Olson. With funding from the U.S. Department of Energy, CALSTART and its project partners assessed the performance, reliability, maintainability and fleet acceptance of three pre-production Class 6 hydraulic hybrid parcel delivery vehicles using information and data from in-use data collection and on-road testing. This document reports on the deployment of these vehicles operated by FedEx Ground, Purolator and UPS. The results presented provide a comprehensive overview of the performance of commercial hydraulic hybrid vehicles in parcel delivery applications. This project also informs fleets and manufacturers on the overall performance of hydraulic hybrid vehicles, provides insights on how the technology can be both improved and more effectively used. The key findings and recommendations of this project fall into four major categories: -Performance, -Fleet deployment, -Maintenance, -Business case. Hydraulic hybrid technology is relatively new to the market, as commercial vehicles have been introduced only in the past few years in refuse and parcel delivery applications. Successful demonstration could pave the way for additional purchases of hydraulic hybrid vehicles throughout the trucking industry. By providing unbiased, third-party assessment of this “hybrid without batteries” technology, this report offers relevant, timely and valuable information to the industry.

  11. Waste feed delivery planning at Hanford

    SciTech Connect (OSTI)

    Certa, Paul J.; West, Elizha B.; Rodriguez, Juissepp S.; Hohl, Ted M.; Larsen, Douglas C.; Ritari, Jaakob S.; Kelly, James W.

    2013-01-10

    The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades.

  12. Hydrogen Distribution and Delivery Infrastructure

    Fuel Cell Technologies Publication and Product Library (EERE)

    This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challen

  13. Hydrogen Delivery Infrastructure Options Analysis

    Fuel Cell Technologies Publication and Product Library (EERE)

    This report, by the Nexant team, documents an in-depth analysis of seven hydrogen delivery options to identify the most cost-effective hydrogen infrastructure for the transition and long term. The pro

  14. Variable delivery, fixed displacement pump

    DOE Patents [OSTI]

    Sommars, Mark F. (Sparland, IL)

    2001-01-01

    A variable delivery, fixed displacement pump comprises a plurality of pistons reciprocated within corresponding cylinders in a cylinder block. The pistons are reciprocated by rotation of a fixed angle swash plate connected to the pistons. The pistons and cylinders cooperate to define a plurality of fluid compression chambers each have a delivery outlet. A vent port is provided from each fluid compression chamber to vent fluid therefrom during at least a portion of the reciprocal stroke of the piston. Each piston and cylinder combination cooperates to close the associated vent port during another portion of the reciprocal stroke so that fluid is then pumped through the associated delivery outlet. The delivery rate of the pump is varied by adjusting the axial position of the swash plate relative to the cylinder block, which varies the duration of the piston stroke during which the vent port is closed.

  15. Best antibiotics for buccal delivery

    E-Print Network [OSTI]

    Goldberg, Manijeh Nazari

    2011-01-01

    The purpose of the research was to identify the clinical and commercial benefits of switching from intravenous (IV) to buccal delivery of antibiotics. then, the research continued to select 3-5 antibiotics that best met ...

  16. Hydrogen Delivery Technology Roadmap, November 2005

    Fuel Cell Technologies Publication and Product Library (EERE)

    Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

  17. Noninvasive Monitoring of Local Drug Release Using X-ray Computed Tomography: Optimization and

    E-Print Network [OSTI]

    Gao, Jinming

    profiles of drug-loaded biodegradable implants were noninvasively monitored and characterized using X yielded a sensitivity of 0.21 mg/mL (or 95 mg iodine/mL) for this agent. In vitro validation of the method samples, and/or removed implants.1 The release profile of a particular drug delivery method

  18. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  19. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  20. Integration and the performance of large-scale health enterprises : field studies of psychological health delivery systems in the U.S. Military

    E-Print Network [OSTI]

    Kamin, Cody M. (Cody Meyer)

    2012-01-01

    Large-scale health enterprises comprise multiple organizations that provide programs and services for patients. Despite the interconnectedness of these systems there is a lack of empirical research documenting how these ...

  1. College of Electricity Delivery and Energy Reliability | Department...

    Energy Savers [EERE]

    Electricity Delivery and Energy Reliability College of Electricity Delivery and Energy Reliability College of Electricity Delivery and Energy Reliability Vision OE recognizes that...

  2. Agenda for the Hydrogen Delivery and Onboard Storage Analysis...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage...

  3. Radioisotope Power System Delivery, Ground Support and Nuclear Safety Implementation: Use of the Multi-Mission Radioisotope Thermoelectric Generator for the NASA's Mars Science Laboratory

    SciTech Connect (OSTI)

    S.G. Johnson; K.L. Lively; C.C. Dwight

    2014-07-01

    Radioisotope power systems have been used for over 50 years to enable missions in remote or hostile environments. They are a convenient means of supplying a few milliwatts up to a few hundred watts of useable, long-term electrical power. With regard to use of a radioisotope power system, the transportation, ground support and implementation of nuclear safety protocols in the field is a complex process that requires clear identification of needed technical and regulatory requirements. The appropriate care must be taken to provide high quality treatment of the item to be moved so it arrives in a condition to fulfill its missions in space. Similarly it must be transported and managed in a manner compliant with requirements for shipment and handling of special nuclear material. This presentation describes transportation, ground support operations and implementation of nuclear safety and security protocols for a radioisotope power system using recent experience involving the Multi-Mission Radioisotope Thermoelectric Generator for National Aeronautics and Space Administration’s Mars Science Laboratory, which launched in November of 2011.

  4. ARM - Data Gathering and Delivery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory of rare Kaonforsupernovae2Gathering and Delivery Data Gathering and Delivery

  5. Strategic Directions for Hydrogen Delivery Workshop Proceedings

    Broader source: Energy.gov [DOE]

    Proceedings from the Strategic Directions for Hydrogen Delivery Workshop held May 7-8, 2003 in Washington, DC. Author: Energetics

  6. Waste Feed Delivery Environmental Permits and Approvals Plan

    SciTech Connect (OSTI)

    TOLLEFSON, K.S.

    2000-01-18

    This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches.

  7. Delivery and Hedging Delivery ties the futures price to the spot price.

    E-Print Network [OSTI]

    Lyuu, Yuh-Dauh

    Delivery and Hedging · Delivery ties the futures price to the spot price. · On the delivery date, the settlement price of the futures contract is determined by the spot price. · Hence, when the delivery period is reached, the futures price should be very close to the spot price. · Changes in futures prices usually

  8. Multirate delivery of multiple therapeutic agents from metal-organic frameworks

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    McKinlay, Alistair C.; Allan, Phoebe K.; Renouf, Catherine L.; Duncan, Morven J.; Wheatley, Paul S.; Warrender, Stewart J.; Dawson, Daniel; Ashbrook, Sharon E.; Gil, Barbara; Marszalek, Bartosz; et al

    2014-12-01

    The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

  9. Radionuclide-binding compound, a radionuclide delivery system, a method of making a radium complexing compound, a method of extracting a radionuclide, and a method of delivering a radionuclide

    DOE Patents [OSTI]

    Fisher, Darrell R. (Richland, WA); Wai, Chien M. (Moscow, ID); Chen, Xiaoyuan (Moscow, ID)

    2000-01-01

    The invention pertains to compounds which specifically bind radionuclides, and to methods of making radionuclide complexing compounds. In one aspect, the invention includes a radionuclide delivery system comprising: a) a calix[n]arene-crown-[m]-ether compound, wherein n is an integer greater than 3, and wherein m is an integer greater than 3, the calix[n]arene-crown-[m]-ether compound comprising at least two ionizable groups; and b) an antibody attached to the calix[n]arene-crown-[m]-ether compound. In another aspect, the invention includes a method of making a radium complexing compound, comprising: a) providing a calix[n]arene compound, wherein n is an integer greater than 3, the calix[n]arene compound comprising n phenolic hydroxyl groups; b) providing a crown ether precursor, the crown ether precursor comprising a pair of tosylated ends; c) reacting the pair of tosylated ends with a pair of the phenolic hydroxyl groups to convert said pair of phenolic hydroxyl groups to ether linkages, the ether linkages connecting the crown ether precursor to the calix[n]arene to form a calix[n]arene-crown-[m]-ether compound, wherein m is an integer greater than 3; d) converting remaining phenolic hydroxyl groups to esters; e) converting the esters to acids, the acids being proximate a crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound; and f) providing a Ra.sup.2+ ion within the crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound.

  10. Engineering translational multi-therapeutic targeted delivery vehicles for disease management

    E-Print Network [OSTI]

    Morton, Stephen Winford

    2015-01-01

    The complexity of growth, survival, and death signaling pathways in cancer continues to motivate extensive investigations using systems biology approaches to better inform treatments. Many of these drugs and drug combinations, ...

  11. Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin

    E-Print Network [OSTI]

    Seto, Jennifer E.

    The simultaneous application of ultrasound and the surfactant sodium lauryl sulfate (referred to as US/SLS) to skin enhances transdermal drug delivery (TDD) in a synergistic mechanical and chemical manner. Since full-thickness ...

  12. Exanthematous allergic drug reactions due to four chemically unrelated drugs

    E-Print Network [OSTI]

    Gupta, Ramji; Gupta, Sameer

    2008-01-01

    16. Lachgar T, Touil Y. The drug hypersensitivity syndromeW, Bircher A, Romano A et al. Drug provocation testing inthe diagnosis of drug hypersensitivity reactions: general

  13. Structural studies of Mycobacterium tuberculosis KatG, an INH drug activator, and Brucella abortus VirB11, an ATPase of type IV translocation system 

    E-Print Network [OSTI]

    Yu, Hong

    2009-05-15

    Catalase-peroxidase (KatG) of Mycobacterium tuberculosis is a bifunctional heme enzyme that has been shown to play an important role in the activation of a first line drug, isoniazid (INH), used in the treatment of ...

  14. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01

    and the risk of illicit drug use: the Adverse Childhoodalcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.

  15. Twelve-Month Evaluation of UPS Diesel Hybrid Electric Delivery Vans

    SciTech Connect (OSTI)

    Lammert, M.

    2009-12-01

    Results of an NREL study of a parallel hybrid electric-diesel propulsion system in United Parcel Service-operated delivery vans show that the hybrids had higher fuel economy than standard diesel vans.

  16. Analysis of oil-pipeline distribution of multiple products subject to delivery time-windows 

    E-Print Network [OSTI]

    Jittamai, Phongchai

    2006-04-12

    This dissertation defines the operational problems of, and develops solution methodologies for, a distribution of multiple products into oil pipeline subject to delivery time-windows constraints. A multiple-product oil pipeline is a pipeline system...

  17. Opto-acoustic recanilization delivery system

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Celliers, Peter M. (Berkeley, CA); London, Richard A. (Orinda, CA); Benett, William (Livermore, CA); Broughton, Kathryn (Berkeley, CA); Esch, Victor (San Francisco, CA)

    2002-01-01

    Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.

  18. Mercury Delivery System Tony Gabriel, Phil Spampinato

    E-Print Network [OSTI]

    McDonald, Kirk

    Jan 2005 Pump Issues · Pump adds heat to Hg - Pump delivers nominal 51 bhp at 23% efficiency (60 bhp.5hp (30kw) · With Vol=12liter, T=2.4°F/sec (1.3°C/sec) due to pump heating only · Max available pump LABORATORY U. S. DEPARTMENT OF ENERGY Targetry Teleconference ­ 13 Jan 2005 Pump Energy Balance Pump Heat

  19. Nitrogen oxide delivery systems for biological media

    E-Print Network [OSTI]

    Skinn, Brian Thomas

    2012-01-01

    Elevated levels of nitric oxide (NO) in vivo are associated with a variety of cellular modifications thought to be mutagenic or carcinogenic. These processes are likely mediated by reactive nitrogen species (RNS) such as ...

  20. Autothermal hydrogen storage and delivery systems

    DOE Patents [OSTI]

    Pez, Guido Peter (Allentown, PA); Cooper, Alan Charles (Macungie, PA); Scott, Aaron Raymond (Allentown, PA)

    2011-08-23

    Processes are provided for the storage and release of hydrogen by means of dehydrogenation of hydrogen carrier compositions where at least part of the heat of dehydrogenation is provided by a hydrogen-reversible selective oxidation of the carrier. Autothermal generation of hydrogen is achieved wherein sufficient heat is provided to sustain the at least partial endothermic dehydrogenation of the carrier at reaction temperature. The at least partially dehydrogenated and at least partially selectively oxidized liquid carrier is regenerated in a catalytic hydrogenation process where apart from an incidental employment of process heat, gaseous hydrogen is the primary source of reversibly contained hydrogen and the necessary reaction energy.

  1. Cybersecurity Procurement Language for Energy Delivery Systems

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomer Service Handbook

  2. Roadmap to Achieve Energy Delivery Systems Cybersecurity

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirley Ann JacksonDepartment ofOffice|inWestMay 13, 2015 TheTechnologies-2015 Updateremoveto Achieve

  3. Vulnerability Analysis of Energy Delivery Control Systems

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirley Ann Jackson About1996HowFOAShowingFuel Efficiency &Report- April 2012 |Vote for

  4. Energy Delivery Systems Cybersecurity | Department of Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submitKansas NuclearElectronicConservation-Agreement Sign In About |

  5. Energy Delivery Systems Cybersecurity | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyInformation Form Employee Information FormJuly 8,

  6. NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM

    E-Print Network [OSTI]

    Hart, Steven N.

    2011-02-22

    Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

  7. Orphanet Berichtsreihe Orphan Drugs Datenerhebung

    E-Print Network [OSTI]

    Manstein, Dietmar J.

    Orphanet Berichtsreihe Orphan Drugs Datenerhebung Verzeichnis der in Europa zugelassenen Orphan Drugs Mit europäischer Orphan-Drug-Designation und europäischer Marktzulassung* Mit europäischer Marktzulassung* ohne vorherige Orphan-Drug-Designation *Zentrales Zulassungsverfahren der Europäischen

  8. HST.151 Principles of Pharmacology, Spring 2003

    E-Print Network [OSTI]

    Rosow, Carl E. (Carl Elliott), 1947-

    An introduction to pharmacology. Topics include mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interactions, and ...

  9. Zoledronic acid-associated symmetrical drug-related intertriginous and flexural exanthema (SDRIFE): report of baboon syndrome in a woman with recurrent metastatic breast cancer after receiving zoledronic acid

    E-Print Network [OSTI]

    Cohen, Philip R

    2015-01-01

    bone metastases of malignancy. Drugs 2008;68:507-534. [PMID:resulting from systemic drugs: is there strife betweensyndrome or intertriginous drug eruption: a report of eleven

  10. Evaluation of Retrofit Delivery Packages

    SciTech Connect (OSTI)

    Berman, M.; Smith, P.; Porse, E.

    2013-07-01

    Residential energy retrofit activities are a critical component of efforts to increase energy efficiency in the U.S. building stock; however, retrofits account for a small percentage of aggregate energy savings at relatively high per unit costs. This report by Building America research team, Alliance for Residential Building Innovation (ARBI), describes barriers to widespread retrofits and evaluates opportunities to improve delivery of home retrofit measures by identifying economies of scale in marketing, energy assessments, and bulk purchasing through pilot programs in portions of Sonoma, Los Angeles, and San Joaquin Counties, CA. These targeted communities show potential and have revealed key strategies for program design, as outlined in the report.

  11. Conceptual approach for Integrated Project Delivery (IPD)

    E-Print Network [OSTI]

    Heller, Barbara

    a guaranteed maximum price. Turnkey Project Delivery: frequently used in power plants, manufacturing facilities team, by simulating to a higher degree project design and construction 2. Lean Construction

  12. Hydrogen Delivery Infrastructure Analysis, Options and Trade...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Analysis, Options and Trade-offs, Transition and Long-term Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs, Transition and Long-term Presentation on Hydrogen...

  13. Strategic Initiatives for Hydrogen Delivery Workshop | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Initiatives for Hydrogen Delivery Workshop The U.S. Department of Energy's Hydrogen Pipeline Working Group Workshop included more than 45 researchers and industry experts. The...

  14. Tissue-Specific Gene Delivery via Nanoparticle Coating

    E-Print Network [OSTI]

    Harris, Todd J.

    The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant ...

  15. Resistance proof, folding-inhibitor drugs

    E-Print Network [OSTI]

    R. Broglia; G. Tiana; R. Berera

    2002-10-09

    Conventional drugs work, as a rule, by inhibiting the enzymatic activity of specific proteins, capping their active site. In this paper we present a model of non- conventional drug design based on the inhibiting effects small peptides obtained from segments of the protein itself have on the folding ability of the system. Such peptides attach to the newly expressed (unfolded) protein and inhibit its folding, inhibition which cannot be avoided but through mutations which in any case denaturate the enzyme. These peptides, or their mimetic molecules, can be used as effective alternative drugs to those already available, displaying the advantage of not suffering from the upraise of resistence.

  16. Status and EAC Recommendations for Electricity Delivery Workforce...

    Energy Savers [EERE]

    Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) This memo,...

  17. Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Vehicles Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery Vehicles The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a...

  18. 2013 Annual Planning Summary for the Office of Electricity Delivery...

    Office of Environmental Management (EM)

    Electricity Delivery and Energy Reliability 2013 Annual Planning Summary for the Office of Electricity Delivery and Energy Reliability The ongoing and projected Environmental...

  19. Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Permeability and Integrity of Hydrogen Delivery Pipelines Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines Project Objectives: To gain basic understanding of...

  20. Lighting and Electrical Team Leadership and Project Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Lighting and Electrical Team Leadership and Project Delivery - 2014 BTO Peer Review Lighting and Electrical Team Leadership and Project Delivery - 2014 BTO Peer Review Project...

  1. Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM...

    Office of Environmental Management (EM)

    Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results This presentation by...

  2. Office of Electricity Delivery and Energy Reliability Cyber Security...

    Energy Savers [EERE]

    Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections On...

  3. Office of Electricity Delivery & Energy Reliability FY 2012 Budget...

    Energy Savers [EERE]

    Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation...

  4. Office of Electricity Delivery And Energy Reliability To Hold...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy...

  5. Secretary of Energy Announces New Office of Electricity Delivery...

    Energy Savers [EERE]

    Announces New Office of Electricity Delivery & Energy Reliability Secretary of Energy Announces New Office of Electricity Delivery & Energy Reliability June 9, 2005 - 1:45pm...

  6. H2A Delivery: Forecourt Compression & Storage Optimization (Part...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery: Forecourt Compression & Storage Optimization (Part II) H2A Delivery: Forecourt Compression & Storage Optimization (Part II) Presentation by Matthew Hooks of TIAX at the...

  7. Fixed drug eruption caused by the Japanese herbal drug kakkonto

    E-Print Network [OSTI]

    Furuichi, Megumi; Hara, Hiroshi; Asano, Yukie; Makino, Teruhiko; Shimizu, Tadamichi

    2010-01-01

    Topical provocation of fixed drug eruption. Br J Dermatol.neglected offender for fixed drug eruptions. Eur J Dermatoloral and non-oral herbal drugs may cause FDE. References 1.

  8. Drug Use and Drug Policy in a Prohibition Regime

    E-Print Network [OSTI]

    MacCoun, Robert; Martin, Karin D.

    2008-01-01

    Prisoners (prior to offense), Drug-related Emergency RoomVisits, 2007 DAWN All illicit drugs Marijuana Cocaine Crack2/4/2008 - 41 Other Sentence Drug Sentence Federal Prisoners

  9. Anticoagulation Drug Therapy: A Review

    E-Print Network [OSTI]

    Harter, Katherine; Levine, Michael; Henderson, Sean O.

    2015-01-01

    et al. Anticoagulation Drug Therapy: A Review 15. NishijimaRandomized antiplatelet drugs. In: Goodman & Gilman’s The2008;24:2757-65. Cardiovasc Drugs. 2006;6:265-85. 34. Nordt

  10. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01

    alcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.outcomes in an indicated drug prevention program for high-

  11. Ultra-Fast Absorption of Amorphous Pure Drug Aerosols Via Deep Lung Inhalation

    E-Print Network [OSTI]

    Rabinowitz, Joshua D.

    Ultra-Fast Absorption of Amorphous Pure Drug Aerosols Via Deep Lung Inhalation JOSHUA D. RABINOWITZ. A promising means of accelerating drug action is through rapid systemic drug administration via deep lung inhalation. The speed of pulmonary drug absorption depends on the site of aerosol deposition within the lung

  12. Quality assurance for online adapted treatment plans: Benchmarking and delivery monitoring simulation

    SciTech Connect (OSTI)

    Li, Taoran Wu, Qiuwen; Yang, Yun; Rodrigues, Anna; Yin, Fang-Fang; Jackie Wu, Q.

    2015-01-15

    Purpose: An important challenge facing online adaptive radiation therapy is the development of feasible and efficient quality assurance (QA). This project aimed to validate the deliverability of online adapted plans and develop a proof-of-concept online delivery monitoring system for online adaptive radiation therapy QA. Methods: The first part of this project benchmarked automatically online adapted prostate treatment plans using traditional portal dosimetry IMRT QA. The portal dosimetry QA results of online adapted plans were compared to original (unadapted) plans as well as randomly selected prostate IMRT plans from our clinic. In the second part, an online delivery monitoring system was designed and validated via a simulated treatment with intentional multileaf collimator (MLC) errors. This system was based on inputs from the dynamic machine information (DMI), which continuously reports actual MLC positions and machine monitor units (MUs) at intervals of 50 ms or less during delivery. Based on the DMI, the system performed two levels of monitoring/verification during the delivery: (1) dynamic monitoring of cumulative fluence errors resulting from leaf position deviations and visualization using fluence error maps (FEMs); and (2) verification of MLC positions against the treatment plan for potential errors in MLC motion and data transfer at each control point. Validation of the online delivery monitoring system was performed by introducing intentional systematic MLC errors (ranging from 0.5 to 2 mm) to the DMI files for both leaf banks. These DMI files were analyzed by the proposed system to evaluate the system’s performance in quantifying errors and revealing the source of errors, as well as to understand patterns in the FEMs. In addition, FEMs from 210 actual prostate IMRT beams were analyzed using the proposed system to further validate its ability to catch and identify errors, as well as establish error magnitude baselines for prostate IMRT delivery. Results: Online adapted plans were found to have similar delivery accuracy in comparison to clinical IMRT plans when validated with portal dosimetry IMRT QA. FEMs for the simulated deliveries with intentional MLC errors exhibited distinct patterns for different MLC error magnitudes and directions, indicating that the proposed delivery monitoring system is highly specific in detecting the source of errors. Implementing the proposed QA system for online adapted plans revealed excellent delivery accuracy: over 99% of leaf position differences were within 0.5 mm, and >99% of pixels in the FEMs had fluence errors within 0.5 MU. Patterns present in the FEMs and MLC control point analysis for actual patient cases agreed with the error pattern analysis results, further validating the system’s ability to reveal and differentiate MLC deviations. Calculation of the fluence map based on the DMI was performed within 2 ms after receiving each DMI input. Conclusions: The proposed online delivery monitoring system requires minimal additional resources and time commitment to the current clinical workflow while still maintaining high sensitivity to leaf position errors and specificity to error types. The presented online delivery monitoring system therefore represents a promising QA system candidate for online adaptive radiation therapy.

  13. Improved Audit Implementation Through Programmed Report Delivery 

    E-Print Network [OSTI]

    Brown, M. L.; Gurta, M. E.; Meffert, W. A.

    1995-01-01

    these barriers, Georgia Tech engineers providing industrial audits have begun a program of delivering audit reports instead of mailing them. Although report delivery does not directly confront barriers relating to organization changes, it can be effective...

  14. Coordinated part delivery using distributed planning

    E-Print Network [OSTI]

    Bolger, Adrienne (Adrienne M.)

    2010-01-01

    In this thesis, we develop a distributed mobile robot platform to deliver parts around a model construction site. The platform's robots, specialized into delivery robots and assembly robots, use a distributed coverage ...

  15. Estimating the Required Investment to Attain Region M Water Savings Through Rehabilitation of Water-Delivery Infrastructure – 2005 Perspectives 

    E-Print Network [OSTI]

    Lacewell, Ronald D.; Rister, M. Edward; Sturdivant, Allen W.

    2005-03-15

    Irrigation districts in the Texas Lower Rio Grande Valley use an antiquated water-delivery conveyance system; which loses substantial water from seepage, evaporation, etc. Pressures are increasing for districts to improve ...

  16. Drug Information Chart Notes Drug ad (intrinsic bias)

    E-Print Network [OSTI]

    Fletcher, Robin

    Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company Dosage Same or different? A drug in a different dosage can be used for a different therapy. Precautions Check for pregnancy A complete book on drugs in pregnancy and lactation in bibliography. (unbiased

  17. DRUG DISCOVERY AT PURDUE 2013-14

    E-Print Network [OSTI]

    Pittendrigh, Barry

    DRUG DISCOVERY AT PURDUE 2013-14 #12;PURDUE UNIVERSITY DRUG DISCOVERY 2 #12;PURDUE UNIVERSITY DRUG DISCOVERY 3 #12;PURDUE UNIVERSITY DRUG DISCOVERY 4 TABLE OF CONTENTS INTRODUCTION ..................................................................................................p. 8 ALPHABETICAL LIST OF DRUG DISCOVERY RESEARCHERS

  18. THE HANFORD WASTE FEED DELIVERY OPERATIONS RESEARCH MODEL

    SciTech Connect (OSTI)

    BERRY J; GALLAHER BN

    2011-01-13

    Washington River Protection Solutions (WRPS), the Hanford tank farm contractor, is tasked with the long term planning of the cleanup mission. Cleanup plans do not explicitly reflect the mission effects associated with tank farm operating equipment failures. EnergySolutions, a subcontractor to WRPS has developed, in conjunction with WRPS tank farms staff, an Operations Research (OR) model to assess and identify areas to improve the performance of the Waste Feed Delivery Systems. This paper provides an example of how OR modeling can be used to help identify and mitigate operational risks at the Hanford tank farms.

  19. Common Cyber Security Vulnerabilities Observed in Control System...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Systems (September 2011) Vulnerability Analysis of Energy Delivery Control Systems - 2011 Lessons Learned from Cyber Security Assessments of SCADA and Energy Management Systems...

  20. Geek-Up[12.10.2010]: A New Planet in Another Solar System, Fast-Tracked Drug Treatments and Better Batteries

    Broader source: Energy.gov [DOE]

    Using high-contrast, near infrared adaptive optics on the Keck II telescope in Hawaii, LLNL astronomers have identified a fourth planet that is part of a new planetary system discovered in 2008.

  1. Superconductivity for Electric Systems

    E-Print Network [OSTI]

    Superconductivity Program Oak Ridge National Laboratory For: Department of Energy Office of Electricity Delivery and Energy Reliability ­ Superconductivity for Electric Systems #12;3 Control Milestones and Status ControlSuperconductivity for Electric Systems Superconductivity Program Quarterly Progress Report

  2. CSU Mail Production Center 6011 Campus Delivery

    E-Print Network [OSTI]

    CSU Mail Production Center 6011 Campus Delivery Phone: 970-491-6142 Fax: 970-491-5012 E-mail: mail.production@colostate.edu MAIL PRODUCTION SERVICE REQUEST CONTACT & BILLING INFORMATION Contact Person Name Mail Code Department Mail Date ** ** Allow up to 5 to 7 days from date materials are received by Mail Production. Inquiries

  3. PREPARING THE VIRTUAL CLASSROOM FOR DISTANCE DELIVERY

    E-Print Network [OSTI]

    Dyer, Bill

    of humans and their companion domestic animals and livestock. Students learn that there are certain "at riskPREPARING THE VIRTUAL CLASSROOM FOR DISTANCE DELIVERY: MEDICAL-VETERINARY ENTOMOLOGY CLINICS laboratory," library materials, conventional lectures and the 43 virtual patients in the clinics

  4. Oral Drug Absorption

    E-Print Network [OSTI]

    Yamashita, Shinji

    2006-10-26

    Stability 0 20 40 60 80 100 25 10 5 1 0.5 size? r 0 (?m) Fr action absor b ed in hum an (% ) Peff =5.0 Peff =3.0 Peff =1.0 Peff =0.5 Peff =0.1 Solubility? Cs = 1.0 (?g/ml) Effect of micronization on intestinal absorption of poorly soluble drugs Peff... ?? permeability to human intestine? (cm/sec x 10 -4 ) 8 Effect of Solubility on intestinal absorption of poorly soluble drugs Cs (?g/ml) 0 5 10 15 50 Fr action absor b ed in hum an (% ) 0 20 40 60 80 100 Peff =5.0 Peff =3.0 Peff =1.0 Peff =0.5 Peff =0.1 r 0 = 1...

  5. Personal Final Exam Schedule ISIS Web Delivery Access Instructions for Students

    E-Print Network [OSTI]

    Personal Final Exam Schedule ISIS Web Delivery Access Instructions for Students 1.) Go to ISIS (Iowa Student Information System) at http://isis.uiowa.edu 2.) Login using your HawkID and password 3 May). - Individual final exam schedules for students are accessible online through the ISIS using

  6. Power Network-on-Chip for Scalable Power Delivery Inna Vaisband and Eby G. Friedman

    E-Print Network [OSTI]

    Friedman, Eby G.

    }@ece.rochester.edu Abstract--Delivering high quality power to the on-chip cir- cuitry with minimum energy loss is an essential component of integrated circuits. The quality of the power supply can be efficiently addressed with multiple complexity of existing power delivery systems. Efficient real-time management of the power budget

  7. Review Guidance for the TWRS FSAR amendment for Waste Retrieval and waste feed delivery

    SciTech Connect (OSTI)

    GRIFFITH, R.W.

    1999-10-01

    This review guidance (Guide) was developed for Office of River Protection (ORP) reviewers to use in reviewing the amendment to the Tank Waste Remediation System (TWRS) Final Safety Analysis Report (FSAR) covering waste retrieval and waste feed delivery. Waste retrieval and waste feed delivery are necessary to supply nuclear waste from TWRS storage tanks to the TWRS Privatization (TWRS-P) Contractor's vitrification facility and to receive intermediate waste from the vitrification facility back into the TWRS tank farms for interim storage. An amendment to the approved TWRS FSAR (HNF-SD-WM-SAR-067, Rev. 0) is necessary to change the authorization basis to accommodate waste retrieval and waste feed delivery. The ORP'S safety responsibility in reviewing the FSAR amendment is to determine that reasonable assurance exists that waste retrieval and waste feed delivery operations can be accomplished with adequate safety for the workers, the public, and the environment. To carry out this responsibility, the ORP will evaluate the Contractor's amendment to the TWRS FSAR for waste retrieval and waste feed delivery to determine whether the submittal provides adequate safety and complies with applicable regulatory requirements.

  8. ON DEMAND DELIVERY OF MULTIMEDIA DOCUMENTS USING DISTRIBUTED OBJECTS

    E-Print Network [OSTI]

    ON DEMAND DELIVERY OF MULTIMEDIA DOCUMENTS USING DISTRIBUTED OBJECTS C. BOURAS1,2 V. OUZOUNIS3 P propose an architecture for the on- demand delivery of multimedia documents over broadband networks using and the on-demand delivery of them should be addressed. These policies should support flexible, modular

  9. Delivery Analysis | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: AlternativeCommunication &20081-929-200499 DOE-STD-3025-99DavidJune 5,DefenseDepartmentSystems

  10. Cryogenics for superconductors: Refrigeration, delivery, and preservation of the cold

    SciTech Connect (OSTI)

    Venkatarao Ganni, James Fesmire

    2012-06-01

    Applications in superconductivity have become widespread, enabled by advancements in cryogenic engineering. In this paper, the history of cryogenic refrigeration, its delivery, its preservation and the important scientific and engineering advancements in these areas in the last 100 years will be reviewed, beginning with small laboratory dewars to very large scale systems. The key technological advancements in these areas that enabled the development of superconducting applications at temperatures from 4 to 77 K are identified. Included are advancements in the components used up to the present state-of-the-art in refrigeration systems design. Viewpoints as both an equipment supplier and the end-user with regard to the equipment design and operations will be presented. Some of the present and future challenges in these areas will be outlined. Most of the materials in this paper are a collection of the historical materials applicable to these areas of interest.

  11. Drug disposition and targeting: Transport across the blood-brain barrier

    E-Print Network [OSTI]

    Rochat, Bertrand; Audus, Kenneth L.

    1999-01-01

    the BBB. Neutral amino-acid carriers have proven to be capable of transporting many amino acids, drugs and endogenous compounds with similar stuctures. Leucine, cysteine, serine, alanine, phenylalanine, L-dopa, L-tryptophan, the alkylating agent... the carriers for opioids at the BBB have not been resolved. The possibility obviously exists, however, for the design and development of opioid peptide therapeutics that target BBB carriers and achieve improve brain delivery (Thomas et al., 1997). The last...

  12. Exploring the Limits of Methane Storage and Delivery in Nanoporous Materials

    SciTech Connect (OSTI)

    Gomez-Gualdron, DA; Wilmer, CE; Farha, OK; Hupp, JT; Snurr, RQ

    2014-04-03

    The physical limits for methane storage and delivery in nanoporous materials were investigated, with a focus on whether it is possible to reach a methane deliverable capacity of 315 cm(3)(STP)/cm(3) in line with the adsorption target established by the ARPA-E agency. Our efforts focused on how both geometric and chemical properties, such as void fraction (V-f), volumetric surface area (S-v), and heat of adsorption (Q(st)), impact methane deliverable capacity, i.e., the amount of methane adsorbed at some storage pressure minus the amount adsorbed at the delivery pressure. With the aid of grand canonical Monte Carlo (GCMC) simulations, we studied methane adsorption and delivery properties in a population of 122 835 hypothetical pcu metal organic frameworks (MOFs) and 39 idealized carbon-based porous materials. From the simulation results, we developed an analytical equation that helped us delimit the necessary material properties to reach specific methane deliverable capacity targets. The maximum deliverable capacity between 65 and 5.8 bar among the hypothetical MOFs was 206 cm(3)(STP)/cm(3) at 298 K. We found that artificially increasing the methane MOF interaction strength by increasing the Lennard-Jones e parameters of the MOF atoms by 2- and 4-fold only improved the maximum deliverable capacity up to 223 and 228 cm(3)(STP)/cm(3), respectively. However, the effect on the amount stored at 65 bar was more significant, which suggested another strategy; raising the temperature of the system by 100 K can recover 70% of the methane stranded at the delivery pressure. By increasing the delivery temperature to 398 K, the ARPA-E target was reached by a few hypothetical MOFs with quadrupled e values. This work shows the difficulty in reaching the ARPA-E target but also suggests that a strategy that combines a material with a large volumetric density of sites that interact strongly with methane and raising the delivery temperature can greatly improve the performance of nanoporous materials for methane storage and delivery. The optimal heat of adsorption in an isothermal storage and delivery scenario is approximately 10.5-14.5 kJ/mol, whereas in the nonisothermal storage and delivery scenario the optimal heats of adsorption fell within a range of 11.8-19.8 kEmol.

  13. Hydrogen production and delivery analysis in US markets : cost, energy and greenhouse gas emissions.

    SciTech Connect (OSTI)

    Mintz, M.; Gillette, J.; Elgowainy, A.

    2009-01-01

    Hydrogen production cost conclusions are: (1) Steam Methane Reforming (SMR) is the least-cost production option at current natural gas prices and for initial hydrogen vehicle penetration rates, at high production rates, SMR may not be the least-cost option; (2) Unlike coal and nuclear technologies, the cost of natural gas feedstock is the largest contributor to SMR production cost; (3) Coal- and nuclear-based hydrogen production have significant penalties at small production rates (and benefits at large rates); (4) Nuclear production of hydrogen is likely to have large economies of scale, but because fixed O&M costs are uncertain, the magnitude of these effects may be understated; and (5) Given H2A default assumptions for fuel prices, process efficiencies and labor costs, nuclear-based hydrogen is likely to be more expensive to produce than coal-based hydrogen. Carbon taxes and caps can narrow the gap. Hydrogen delivery cost conclusions are: (1) For smaller urban markets, compressed gas delivery appears most economic, although cost inputs for high-pressure gas trucks are uncertain; (2) For larger urban markets, pipeline delivery is least costly; (3) Distance from hydrogen production plant to city gate may change relative costs (all results shown assume 100 km); (4) Pipeline costs may be reduced with system 'rationalization', primarily reductions in service pipeline mileage; and (5) Liquefier and pipeline capital costs are a hurdle, particularly at small market sizes. Some energy and greenhouse gas Observations: (1) Energy use (per kg of H2) declines slightly with increasing production or delivery rate for most components (unless energy efficiency varies appreciably with scale, e.g., liquefaction); (2) Energy use is a strong function of production technology and delivery mode; (3) GHG emissions reflect the energy efficiency and carbon content of each component in a production-delivery pathway; (4) Coal and natural gas production pathways have high energy consumption and significant GHG emissions (in the absence of carbon caps, taxes or sequestration); (5) Nuclear pathway is most favorable from energy use and GHG emissions perspective; (6) GH2 Truck and Pipeline delivery have much lower energy use and GHG emissions than LH2 Truck delivery; and (7) For LH2 Truck delivery, the liquefier accounts for most of the energy and GHG emissions.

  14. Charge-based transport and drug delivery into cartilage for localized treatment of degenerative joint diseases

    E-Print Network [OSTI]

    Bajpayee, Ambika Goel

    2015-01-01

    Traumatic joint injuries significantly increase synovial fluid levels of pro-inflammatory cytokines that can initiate cartilage degeneration leading to osteoarthritis (OA). Articular cartilage is a highly negatively charged, ...

  15. Chemically modified and nanostructured porous silicon as a drug delivery material and device

    E-Print Network [OSTI]

    Anglin, Emily Jessica

    2007-01-01

    Curtis, C. L. ; Doan, V. V. ; Credo, G. M. ; Sailor, M. J. ,J. L. ; Curtis, C. L. ; Credo, G. M. ; Kavanagh, K. L. ;Curtis, C. L. ; Doan, V. V. ; Credo, G. M. ; Sailor, M. J. ,

  16. Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites

    E-Print Network [OSTI]

    Perelman, Loren Avery

    2008-01-01

    Sailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructure

  17. Chemically modified and nanostructured porous silicon as a drug delivery material and device

    E-Print Network [OSTI]

    Anglin, Emily Jessica

    2007-01-01

    Sailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructureSailor, M.J. , Engineering the chemistry and nanostructure

  18. Chemically modified and nanostructured porous silicon as a drug delivery material and device

    E-Print Network [OSTI]

    Anglin, Emily Jessica

    2007-01-01

    Sealed Source for Cancer Brachytherapy. Abstracts of Porousnovel approach to brachytherapy in hepatocellular carcinomaSealed Source for Cancer Brachytherapy. Abstracts of Porous

  19. Novel Approaches to Breast Cancer Therapy: Evaluation of Next Generation Dendrimers for Drug Delivery 

    E-Print Network [OSTI]

    Snow, Merideth

    2010-07-14

    concentrations while dendrimers F4-1 and F2-1 were not. The dendrimer compounds may represent the future of breast cancer therapy....

  20. Genome-Free Viral Capsids for Targeted Drug Delivery to Breast Cancer

    E-Print Network [OSTI]

    Wu, Wesley

    2012-01-01

    phage as determined by UV measurements at 260 nm (OD 260 /synthesizer. UV-Vis spectroscopic measurements were

  1. Chemically modified and nanostructured porous silicon as a drug delivery material and device

    E-Print Network [OSTI]

    Anglin, Emily Jessica

    2007-01-01

    band at 242 nm. UV absorbance measurements were takenby concurrent measurements involving UV absorbanceUV-visible absorption spectroscopy), and by measurement of

  2. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

    E-Print Network [OSTI]

    Chauhan, Vikash P.

    Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...

  3. Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

    DOE Patents [OSTI]

    Tour, James M.; Lucente-Schultz, Rebecca; Leonard, Ashley; Kosynkin, Dmitry V.; Price, Brandi Katherine; Hudson, Jared L.; Conyers, Jr., Jodie L.; Moore, Valerie C.; Casscells, S. Ward; Myers, Jeffrey N.; Milas, Zvonimir L.; Mason, Kathy A.; Milas, Luka

    2014-07-22

    Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

  4. Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites

    E-Print Network [OSTI]

    Perelman, Loren Avery

    2008-01-01

    a similarly rapid volume phase transition 9, 26 . 4.4.9to undergo rapid volume phase transition upon heating orrapid compared with the published rates attributed to the volume phase transition

  5. Study of Mesoporous Silica Nanoparticles' (MSNs) intracellular trafficking and their application as drug delivery vehicles

    E-Print Network [OSTI]

    Yanes, Rolando Eduardo

    2013-01-01

    E, Ho D. Active nanodiamond hydrogels for chemotherapeuticpolymers, lipids, gold, nanodiamond, silicon and mesoporousand these include gold, nanodiamond, silicon, and mesoporous

  6. pH-sensitive core-shell nanoparticles for intracellular drug delivery

    E-Print Network [OSTI]

    Hu, Yuhua, Ph. D. Massachusetts Institute of Technology

    2008-01-01

    Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis ...

  7. Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites

    E-Print Network [OSTI]

    Perelman, Loren Avery

    2008-01-01

    of nanoporous silicon after coating with a polymer. J. Appl.biosensor was constructed by coating the surface of the23 2.3.4 Protein coating……………………………………………………23 2.3.5

  8. A Universal Level Converter Towards the Realization of Energy Efficient Implantable Drug Delivery

    E-Print Network [OSTI]

    Mohanty, Saraju P.

    with dual- VT h technique. The robustness of the design is tested by car- rying out three types of analysis, namely: parametric, load and power. It is observed that the ULC produces a stable output for voltages as low as 0.35V and loads varying from 50fF to 120fF. The average power dissipation of the proposed level

  9. Tri-partite complex for axonal transport drug delivery achieves pharmacological effect

    E-Print Network [OSTI]

    Filler, Aaron G.; Whiteside, Garth T.; Bacon, Mark; Frederickson, Martyn; Howe, Franklyn A.; Rabinowitz, Miri D.; Sokoloff, Alan J.; Deacon, Terrence W.; Abell, Chris; Munglani, Raj; Griffiths, John R.; Bell, B. Anthony; Lever, Andrew M. L.

    2010-01-20

    be large when compared to the amount in the small volume of the nerve. In part, this reflects the fact that WGA adheres to muscle cell membranes [36] as well as being taken up by adsorptive endocytosis at nerve ter- mini. This also explains a depot effect...

  10. Mechanized Mesoporous Inorganic Nanoparticles for Drug Delivery Applications: Design, Optimization and Properties

    E-Print Network [OSTI]

    Xue, Min

    2013-01-01

    crude was purified by column chromatography (SiO 2 , Hexanes/EtOAc 3:1) to yield 6 as a colorless oil (

  11. Intraperitoneal Injection as a Method of Psychotropic Drug Delivery in Adult Zebrafish

    E-Print Network [OSTI]

    Kalueff, Allan V.

    Adam Stewart, Jonathan M. Cachat, Christopher Suciu, Peter C. Hart, Siddharth Gaikwad, Eli Utterback delivered to an individual animal. Here we outline a simple protocol for the intraperitoneal injection (eds.), Zebrafish Neurobehavioral Protocols, Neuromethods 51, DOI 10

  12. Development of lymphatic drug delivery platforms for the treatment of carcinomas

    E-Print Network [OSTI]

    Cai, Shuang

    2011-05-31

    remains controversial due to the mixed clinical results of its efficacy in treating liver cancers [52-54]. Although TACE is an independent procedure, it can be performed in combination with other procedures, such as a percutaneous ethanol injection (PEI... the most widely route used for delivering lymphatic-targeted chemotherapeutic agents in preclinical trials. The fate of subcutaneously injected materials depends on a variety of factors, including the size, charge, and immunogenicity. The optimal size...

  13. Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA

    SciTech Connect (OSTI)

    Ma Ham, Aihui; Wu, Hong J.; Wang, Jun; Kang, Xinhuang; Zhang, Youyu; Lin, Yuehe

    2011-05-11

    Apoferritin is a nanostructured material with a uniform size and spherical structure, and it has excellent bio-compatibility. In this work, we report the use of apoferritin as a novel and biocompatible carrier for stabilizing enzymes and their activities. We used glucose oxidase (GOx) as a model enzyme. GOx was immobilized on the surface of the apoferritin through a green synthetic approach taking advantage of bioaffinity binding between streptavidin and biotin. As a result, a glucose oxidase-biotin/streptavidin/biotin-apoferritin conjugate (Apo-GOx) was prepared using streptavidin as a bridge. The synthesized Apo-GOx was characterized with transmission electron microscopy, ultraviolet, and fluorescence spectroscopy. The activity and stability of GOx on the surface of the apoferritin were studied in different environments, such as temperature, chemicals, and pH, in comparison with the biotinylated GOx (B-GOx). The results showed that the activity of GOx on the apoferritin surface was significantly enhanced. The thermal and chemical stability of the GOx on the apoferritin was also greatly improved compared to free B-GOx in a solution. It was found that the activity of the GOx on the apoferritin only lost 30% in comparison to a 70% loss of free B-GOx after a 2-hr incubation at 50oC. There was almost no decrease in activity for the GOx on the apoferritin as compared to an 80% activity decrease for free B-GOx after 30 minutes of incubation in a 5 M urea solution. The GOx immobilized apoferritin nanoparticles exhibited high sensitivity for glucose detection with a detection limit of 3 nM glucose. This work offers a novel approach for immobilizing enzymes with enhanced stability and activity, and this method may find a number of applications, such as in catalysis and bioassys/biosensors.

  14. Nanoporous inorganic membranes or coatings for sustained drug delivery in implantable devices

    E-Print Network [OSTI]

    Sridhar, Srinivas

    ), titanium oxide (TiO2) and porous silicon are highlighted with illustrative examples. The critical issues. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 307 2.2. Titania nanotubes

  15. An intraperitoneal implantable drug delivery device for the treatment of ovarian cancer

    E-Print Network [OSTI]

    Ye, Hongye

    2014-01-01

    Ovarian cancer is the fifth leading cause of cancer-related deaths in women and the deadliest gynecologic cancer. The current standard treatment for advanced ovarian cancer includes a minimally invasive cytoreduction ...

  16. Design, synthesis, and evaluation of dendrimers based on melamine as drug delivery vehicles 

    E-Print Network [OSTI]

    Lim, Jong Doo

    2009-05-15

    ), 1.44 (s, 18H); 13 C NMR (75 MHz, CDCl 3 ) ? 156.26, 79.13, 47.54, 39.05, 29.86, 28.55; MS (ESI-TOF) calcd for C 16 H 33 N 3 O 4 331.25, found 332.27 (M+H) + . Intermediate 3. A reaction solution of 2 (5.0 g, 15.1 mmol) and DIPEA (8.0 mL, 46....12, 165.77, 164.86, 156.13, 135.69, 133.74, 129.72, 127.75, 79.05, 72.35, 70.26, 63.50, 47.97, 43.32, 42.14, 40.73, 39.74, 37.28, 36.96, 29.85, 28.61, 27.66, 27.04, 26.92, 26.79, 19.28; MS (MALDI-TOF) calcd for C 45 H 73 N 9 O 6 Si 863.55, found 864...

  17. Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites

    E-Print Network [OSTI]

    Perelman, Loren Avery

    2008-01-01

    S. A. , Polymerized colloidal crystal hydrogel films asS. A. , Polymerized colloidal crystal hydrogel films ashydrogels with silica colloidal crystal templates 9, 14, or

  18. Synthesis and Characterization of Lipid-Polymer Hybrid Nanoparticles for Combinatorial Drug Delivery

    E-Print Network [OSTI]

    Stavropoulos, Kathy

    2011-08-31

    that has versatile functionality, good serum stability, circulates in the body long enough to reach the targeting tissues, and is biocompatible. A promising formulation platform that embodies these features is the lipid-polymer hybrid nanoparticles...

  19. Nano compartments may aid drug delivery, catalyst design > Archived News

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines lightGeospatialDevelopment of09Sponsor GuidelinesGlennNancy M.NanoStorage

  20. Encapsulation of Hydrophobic Drugs in a Copolymer: Glass Transition Behavior and Miscibility Evaluation

    E-Print Network [OSTI]

    North Texas, University of

    Encapsulation of Hydrophobic Drugs in a Copolymer: Glass Transition Behavior and Miscibility, Greece The knowledge of glass transition temperatures Tg in drug + polymer systems is indispensable for drug encapsulation. Tg values as a function of composition make possible the determination whether

  1. The Impact of the Katy Management of Automated Curriculum System on Planning for Learning, Delivery of Instruction and Evaluation of Student Learning as Perceived by Teachers in the Katy Independent School District in Texas 

    E-Print Network [OSTI]

    Hogue, Sharon L.

    2011-10-21

    of student learning in the classroom. KMAC is a customized, proprietary networked technology curriculum management system created for online access to curriculum and the creation and sharing of lesson plans. Data was collected from 635 teachers district...

  2. Office of Electricity Delivery and Energy Reliability

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested Parties -DepartmentAvailableHigh SpatialElectricity Delivery and Energy

  3. Hydrogen Delivery Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuelsof Energy ServicesContractingManagement » Human ResourceHydrogen Delivery

  4. Preparation of a Magnetically Switchable Bioelectrocatalytic System Employing Cross-Linked Enzyme Aggregates in Magnetic Mesocellular Carbon Foam

    SciTech Connect (OSTI)

    Lee, Jinwoo; Lee, Dohun; Oh, Eunkeu; Kim, Jaeyun; Kim, Young-Pil; Jin, Sunmi; Kim, Hak Sung; Hwang, Yosun; Kwak, Ja Hun; Park, Je-Geun; Shin, Chae-Ho; Kim, Jungbae; Hyeon, Taeghwan

    2005-11-18

    Nanostructured magnetic materials (NMMs)[1] have attracted much attention recently because of their broad biotechnological applications including support matrices for enzyme immobilization,[2] immunoassays,[3] drug delivery,[4] and biosensors.[ 5] Specifically, the easy separation and controlled placement of NMMs by means of an external magnetic field enables their application in the development of immobilized enzyme processes[2] and the construction of magnetically controllable bio-electrocatalytic systems.[5, 6] Herein, we demonstrate the use of immobilized enzymes in NMMs for magnetically switchable bio-electrocatalysis.

  5. Solid source MOCVD system

    DOE Patents [OSTI]

    Hubert, Brian N. (Yakima, WA); Wu, Xin Di (San Jose, CA)

    1998-01-01

    A system for MOCVD fabrication of superconducting and non-superconducting oxide films provides a delivery system for the feeding of metalorganic precursors for multi-component chemical vapor deposition. The delivery system can include multiple cartridges containing tightly packed precursor materials. The contents of each cartridge can be ground at a desired rate and fed together with precursor materials from other cartridges to a vaporization zone and then to a reaction zone within a deposition chamber for thin film deposition.

  6. Solid source MOCVD system

    DOE Patents [OSTI]

    Hubert, B.N.; Wu, X.D.

    1998-10-13

    A system for MOCVD fabrication of superconducting and non-superconducting oxide films provides a delivery system for the feeding of metallorganic precursors for multi-component chemical vapor deposition. The delivery system can include multiple cartridges containing tightly packed precursor materials. The contents of each cartridge can be ground at a desired rate and fed together with precursor materials from other cartridges to a vaporization zone and then to a reaction zone within a deposition chamber for thin film deposition. 13 figs.

  7. WE-D-BRD-01: Innovation in Radiation Therapy Delivery: Advanced Digital Linac Features

    SciTech Connect (OSTI)

    Xing, L; Wong, J; Li, R

    2014-06-15

    Last few years has witnessed significant advances in linac technology and therapeutic dose delivery method. Digital linacs equipped with high dose rate FFF beams have been clinically implemented in a number of hospitals. Gated VMAT is becoming increasingly popular in treating tumors affected by respiratory motion. This session is devoted to update the audience with these technical advances and to present our experience in clinically implementing the new linacs and dose delivery methods. Topics to be covered include, technical features of new generation of linacs from different vendors, dosimetric characteristics and clinical need for FFF-beam based IMRT and VMAT, respiration-gated VMAT, the concept and implementation of station parameter optimized radiation therapy (SPORT), beam level imaging and onboard image guidance tools. Emphasis will be on providing fundamental understanding of the new treatment delivery and image guidance strategies, control systems, and the associated dosimetric characteristics. Commissioning and acceptance experience on these new treatment delivery technologies will be reported. Clinical experience and challenges encountered during the process of implementation of the new treatment techniques and future applications of the systems will also be highlighted. Learning Objectives: Present background knowledge of emerging digital linacs and summarize their key geometric and dosimetric features. SPORT as an emerging radiation therapy modality specifically designed to take advantage of digital linacs. Discuss issues related to the acceptance and commissioning of the digital linacs and FFF beams. Describe clinical utility of the new generation of digital linacs and their future applications.

  8. PHCL4003: Anti-infective drugs: Drugs that kill invaders -2015 Spring Course Co-Directors

    E-Print Network [OSTI]

    Marchant, Jonathan

    1 PHCL4003: Anti-infective drugs: Drugs that kill invaders - 2015 Spring Course Co to antimicrobial chemotherapy Jan. 26: 2. Principles of antibacterial drugs I: Drug targets and cytotoxicity Jan. 28: 3. Principles of antibacterial drugs II: Drug resistance Feb. 2: 4. Antibacterial drugs

  9. Innovative Office Lighting System with Integrated Spectrally...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    an innovative LED office lighting system solution that integrates light delivery, optics, and controls for energy efficiency and occupant health and well-being. The office...

  10. A novel nanoscale delivery system for spatio-temporal delivery of combination chemotherapy

    E-Print Network [OSTI]

    Eavarone, David A. (David Alan)

    2009-01-01

    In the continuing search for effective treatments for cancer, the emerging model is the combination of traditional chemotherapy with anti-angiogenesis agents that inhibit blood vessel growth. However, the implementation ...

  11. Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance

    E-Print Network [OSTI]

    Wu, Alan HB

    2011-01-01

    this article as: Wu: Drug metabolizing enzyme activitiesgenetic variances for drug of clinical pharmacogenomicPROTEOMICS Open Access Drug metabolizing enzyme activities

  12. Steam distribution and energy delivery optimization using wireless sensors

    SciTech Connect (OSTI)

    Olama, Mohammed M [ORNL; Allgood, Glenn O [ORNL; Kuruganti, Phani Teja [ORNL; Sukumar, Sreenivas R [ORNL; Djouadi, Seddik M [ORNL; Lake, Joe E [ORNL

    2011-01-01

    The Extreme Measurement Communications Center at Oak Ridge National Laboratory (ORNL) explores the deployment of a wireless sensor system with a real-time measurement-based energy efficiency optimization framework in the ORNL campus. With particular focus on the 12-mile long steam distribution network in our campus, we propose an integrated system-level approach to optimize the energy delivery within the steam distribution system. We address the goal of achieving significant energy-saving in steam lines by monitoring and acting on leaking steam valves/traps. Our approach leverages an integrated wireless sensor and real-time monitoring capabilities. We make assessments on the real-time status of the distribution system by mounting acoustic sensors on the steam pipes/traps/valves and observe the state measurements of these sensors. Our assessments are based on analysis of the wireless sensor measurements. We describe Fourier-spectrum based algorithms that interpret acoustic vibration sensor data to characterize flows and classify the steam system status. We are able to present the sensor readings, steam flow, steam trap status and the assessed alerts as an interactive overlay within a web-based Google Earth geographic platform that enables decision makers to take remedial action. We believe our demonstration serves as an instantiation of a platform that extends implementation to include newer modalities to manage water flow, sewage and energy consumption.

  13. Synthesis and characterization of pharmaceutical surfactant templated mesoporous silica: Its application to controlled delivery of duloxetine

    SciTech Connect (OSTI)

    Mani, Ganesh; Pushparaj, Hemalatha; Peng, Mei Mei; Muthiahpillai, Palanichamy [Department of Chemical Engineering, Hanseo University, Seosan-si 356 706 (Korea, Republic of); Udhumansha, Ubaidulla [Department of Chemical Engineering, Hanseo University, Seosan-si 356 706 (Korea, Republic of); Department of Pharmaceutics, C.L. Baid Metha College of Pharmacy, Chennai (India); Jang, Hyun Tae, E-mail: htjang@hanseo.ac.kr [Department of Chemical Engineering, Hanseo University, Seosan-si 356 706 (Korea, Republic of)

    2014-03-01

    Graphical abstract: - Highlights: • Usefulness of dual pharmaceutical surfactants in silica synthesis was evaluated. • Effects of concentration of secondary template (Tween-40) were studied. • Effects of fixed solvothermal condition on mesostructure formation were studied. • Duloxetine drug loading capability was studied. • Sustained release of duloxetine was evaluated. - Abstract: A new group of mesoporous silica nanoparticles (MSNs) were synthesized using combination pharmaceutical surfactants, Triton X-100 and Tween-40 as template and loaded with duloxetine hydrochloride (DX), for improving the sustained release of DX and patterns with high drug loading. Agglomerated spherical silica MSNs were synthesized by sol–gel and solvothermal methods. The calcined and drug loaded MSNs were characterized using X-ray diffraction (XRD), Braunner–Emmett–Teller (BET), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), diffuse reflectance ultraviolet–visible (DRS-UV–vis) spectroscopy. MSNs with high surface area and pore volume were selected and studied for their DX loading and release. The selected MSNs can accommodate a maximum of 34% DX within it. About 90% was released at 200 h and hence, the synthesized MSNs were capable of engulfing DX and sustain its release. Further form the Ritger and Peppas, Higuchi model for mechanism drug release from all the MSN matrices follows anomalous transport or Non-Fickian diffusion with the ‘r’ and ‘n’ value 0.9 and 0.45 < n < 1, respectively. So, from this study it could be concluded that the MSNs synthesized using pharmaceutical templates were better choice of reservoir for the controlled delivery of drug which requires sustained release.

  14. TIMELY DELIVERY OF LASER INERTIAL FUSION ENERGY (LIFE)

    SciTech Connect (OSTI)

    Dunne, A M

    2010-11-30

    The National Ignition Facility (NIF), the world's largest and most energetic laser system, is now operational at Lawrence Livermore National Laboratory. A key goal of the NIF is to demonstrate fusion ignition for the first time in the laboratory. Its flexibility allows multiple target designs (both indirect and direct drive) to be fielded, offering substantial scope for optimization of a robust target design. In this paper we discuss an approach to generating gigawatt levels of electrical power from a laser-driven source of fusion neutrons based on these demonstration experiments. This 'LIFE' concept enables rapid time-to-market for a commercial power plant, assuming success with ignition and a technology demonstration program that links directly to a facility design and construction project. The LIFE design makes use of recent advances in diode-pumped, solid-state laser technology. It adopts the paradigm of Line Replaceable Units utilized on the NIF to provide high levels of availability and maintainability and mitigate the need for advanced materials development. A demonstration LIFE plant based on these design principles is described, along with the areas of technology development required prior to plant construction. A goal-oriented, evidence-based approach has been proposed to allow LIFE power plant rollout on a time scale that meets policy imperatives and is consistent with utility planning horizons. The system-level delivery builds from our prior national investment over many decades and makes full use of the distributed capability in laser technology, the ubiquity of semiconductor diodes, high volume manufacturing markets, and U.S. capability in fusion science and nuclear engineering. The LIFE approach is based on the ignition evidence emerging from NIF and adopts a line-replaceable unit approach to ensure high plant availability and to allow evolution from available technologies and materials. Utilization of a proven physics platform for the ignition scheme is an essential component of an acceptably low-risk solution. The degree of coupling seen on NIF between driver and target performance mandates that little deviation be adopted from the NIF geometry and beamline characteristics. Similarly, the strong coupling between subsystems in an operational power plant mandates that a self-consistent solution be established via an integrated facility delivery project. The benefits of separability of the subsystems within an IFE plant (driver, chamber, targets, etc.) emerge in the operational phase of a power plant rather than in its developmental phase. An optimized roadmap for IFE delivery needs to account for this to avoid nugatory effort and inconsistent solutions. For LIFE, a system design has been established that could lead to an operating power plant by the mid-2020s, drawing from an integrated subsystem development program to demonstrate the required technology readiness on a time scale compatible with the construction plan. Much technical development work still remains, as does alignment of key stakeholder groups to this newly emerging development option. If the required timeline is to be met, then preparation of a viable program is required alongside the demonstration of ignition on NIF. This will enable timely analysis of the technical and economic case and establishment of the appropriate delivery partnership.

  15. Predicting Crystallisation of Amorphous Drugs With Terahertz Spectroscopy

    E-Print Network [OSTI]

    Sibik, Juraj; Lobmann, Korbinian; Rades, Thomas; Zeitler, J. Axel

    2015-06-19

    solubility and dissolution rate.1,4 This can be exploited for applications such as in the pharmaceutical field to increase bioavailability of poorly soluble drugs when administered orally in the form of tablets or capsules. However, from a thermodynamic point... of amorphous systems, such as amorphous drugs, in order to prevent their crystallisation over the shelf life of a final product. Materials and Methods Materials. Paracetamol, indomethacin and flufenamic acid were obtained from Sigma- Aldrich (St. Louis, MA, USA...

  16. Data driven health system

    E-Print Network [OSTI]

    Rosen Ceruolo, Melissa Beth

    2013-01-01

    Effective use of data is believed to be the key to address systemic inefficiencies in health innovation and delivery, and to significantly enhance value creation for patients and all stakeholders. However, there is no ...

  17. Real time sensor for therapeutic radiation delivery

    DOE Patents [OSTI]

    Bliss, Mary (West Richland, WA); Craig, Richard A. (West Richland, WA); Reeder, Paul L. (Richland, WA)

    1998-01-01

    The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body.

  18. Real time sensor for therapeutic radiation delivery

    DOE Patents [OSTI]

    Bliss, M.; Craig, R.A.; Reeder, P.L.

    1998-01-06

    The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body. 14 figs.

  19. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProteinTotal natural gasPurchase, Delivery, and Storage of

  20. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProteinTotal natural gasPurchase, Delivery, and Storage

  1. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProteinTotal natural gasPurchase, Delivery, and

  2. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) by Carbon-RichProton Delivery and Removal inPublications&Purchase,

  3. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) by Carbon-RichProton Delivery and Removal

  4. Gaseous Hydrogen Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuelsof Energy Services »Information ResourcesHeat &Department ofDelivery

  5. Systems Theory for Pharmaceutical Drug Discovery

    E-Print Network [OSTI]

    Aswani, Anil Jayanti

    2010-01-01

    3):371–381, 2002. [204] Alan Turing. The chemical basis ofwas the seminal paper by Alan Turing on morphogenesis. The

  6. Office of Electricity Delivery and Energy Reliability | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    & Internships Funding Opportunities Information Center Contact Us Energy.gov Office of Electricity Delivery & Energy Reliability 1000 Independence Avenue, SW Washington, DC...

  7. ,"Maine Natural Gas Exports (No Intransit Deliveries) (Million...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Maine Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)",1,"Annual",2014...

  8. OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY (OE)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Harbor (where the island's petroleum terminals are located). U.S. Department of Energy Situation Report U.S. Department of Energy Office of Electricity Delivery & Energy...

  9. Vectren Energy Delivery of Indiana (Electric)- Commercial New Construction Rebates

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery offers commercial customers in Indiana electric rebates for the installation of certain types of equipment in newly constructed buildings through its Energy Design Assist...

  10. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...

    Broader source: Energy.gov (indexed) [DOE]

    An in-depth comparative analysis of promising infrastructure options for hydrogen delivery and distribution to refueling stations from central, semi-central, and distributed...

  11. PHEV Parcel Delivery Truck Model - Development and Preliminary Results (Presentation)

    SciTech Connect (OSTI)

    Barnitt, R

    2009-10-28

    Describes results of a study to determine the impact of drive cycles on the energy- and cost-effectiveness of plug-in hybrid electric delivery vans.

  12. BioDelivery Sciences International, Inc. - Product Pipeline Review...

    Open Energy Info (EERE)

    BioDelivery Sciences International, Inc. - Product Pipeline Review - 2014 By Radiant Insights Home > Groups > Future of Condition Monitoring for Wind Turbines Marketresearchri's...

  13. AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery

    SciTech Connect (OSTI)

    Tsai, Yingssu; McPhillips, Scott E.; González, Ana; McPhillips, Timothy M.; Zinn, Daniel; Cohen, Aina E.; Feese, Michael D.; Bushnell, David; Tiefenbrunn, Theresa; Stout, C. David; Ludaescher, Bertram; Hedman, Britt; Hodgson, Keith O.; Soltis, S. Michael

    2013-05-01

    New software has been developed for automating the experimental and data-processing stages of fragment-based drug discovery at a macromolecular crystallography beamline. A new workflow-automation framework orchestrates beamline-control and data-analysis software while organizing results from multiple samples. AutoDrug is software based upon the scientific workflow paradigm that integrates the Stanford Synchrotron Radiation Lightsource macromolecular crystallography beamlines and third-party processing software to automate the crystallography steps of the fragment-based drug-discovery process. AutoDrug screens a cassette of fragment-soaked crystals, selects crystals for data collection based on screening results and user-specified criteria and determines optimal data-collection strategies. It then collects and processes diffraction data, performs molecular replacement using provided models and detects electron density that is likely to arise from bound fragments. All processes are fully automated, i.e. are performed without user interaction or supervision. Samples can be screened in groups corresponding to particular proteins, crystal forms and/or soaking conditions. A single AutoDrug run is only limited by the capacity of the sample-storage dewar at the beamline: currently 288 samples. AutoDrug was developed in conjunction with RestFlow, a new scientific workflow-automation framework. RestFlow simplifies the design of AutoDrug by managing the flow of data and the organization of results and by orchestrating the execution of computational pipeline steps. It also simplifies the execution and interaction of third-party programs and the beamline-control system. Modeling AutoDrug as a scientific workflow enables multiple variants that meet the requirements of different user groups to be developed and supported. A workflow tailored to mimic the crystallography stages comprising the drug-discovery pipeline of CoCrystal Discovery Inc. has been deployed and successfully demonstrated. This workflow was run once on the same 96 samples that the group had examined manually and the workflow cycled successfully through all of the samples, collected data from the same samples that were selected manually and located the same peaks of unmodeled density in the resulting difference Fourier maps.

  14. Quality control procedures for dynamic treatment delivery techniques involving couch motion

    SciTech Connect (OSTI)

    Yu, Victoria Y.; Fahimian, Benjamin P.; Xing, Lei; Hristov, Dimitre H.

    2014-08-15

    In this study, the authors introduce and demonstrate quality control procedures for evaluating the geometric and dosimetric fidelity of dynamic treatment delivery techniques involving treatment couch motion synchronous with gantry and multileaf collimator (MLC). Tests were designed to evaluate positional accuracy, velocity constancy and accuracy for dynamic couch motion under a realistic weight load. A test evaluating the geometric accuracy of the system in delivering treatments over complex dynamic trajectories was also devised. Custom XML scripts that control the Varian TrueBeam™ STx (Serial #3) axes in Developer Mode were written to implement the delivery sequences for the tests. Delivered dose patterns were captured with radiographic film or the electronic portal imaging device. The couch translational accuracy in dynamic treatment mode was 0.01 cm. Rotational accuracy was within 0.3°, with 0.04 cm displacement of the rotational axis. Dose intensity profiles capturing the velocity constancy and accuracy for translations and rotation exhibited standard deviation and maximum deviations below 3%. For complex delivery involving MLC and couch motions, the overall translational accuracy for reproducing programmed patterns was within 0.06 cm. The authors conclude that in Developer Mode, TrueBeam™ is capable of delivering dynamic treatment delivery techniques involving couch motion with good geometric and dosimetric fidelity.

  15. Eighteen-Month Final Evaluation of UPS Second Generation Diesel Hybrid-Electric Delivery Vans

    SciTech Connect (OSTI)

    Lammert, M.; Walkowicz, K.

    2012-09-01

    A parallel hybrid-electric diesel delivery van propulsion system was evaluated at a UPS facility in Minneapolis using on-vehicle data logging, fueling, and maintenance records. Route and drive cycle analysis showed different duty cycles for hybrid vs. conventional delivery vans; routes were switched between the study groups to provide a valid comparison. The hybrids demonstrated greater advantage on the more urban routes; the initial conventional vans' routes had less dense delivery zones. The fuel economy of the hybrids on the original conventional group?s routes was 10.4 mpg vs. 9.2 mpg for the conventional group on those routes a year earlier. The hybrid group's fuel economy on the original hybrid route assignments was 9.4 mpg vs. 7.9 mpg for the conventional group on those routes a year later. There was no statistically significant difference in total maintenance cost per mile or for the vehicle total cost of operation per mile. Propulsion-related maintenance cost per mile was 77% higher for the hybrids, but only 52% more on a cost-per-delivery-day basis. Laboratory dynamometer testing demonstrated 13%-36% hybrid fuel economy improvement, depending on duty cycle, and up to a 45% improvement in ton-mi/gal. NOx emissions increased 21%-49% for the hybrids in laboratory testing.

  16. Helical tomotherapy with dynamic running-start-stop delivery compared to conventional tomotherapy delivery

    SciTech Connect (OSTI)

    Rong, Yi, E-mail: yi.rong@osumc.edu [Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210 (United States)] [Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210 (United States); Chen, Yu; Lu, Weiguo [21st Century Oncology, Madison, Wisconsin 53719 (United States)] [21st Century Oncology, Madison, Wisconsin 53719 (United States); Shang, Lu [Guangxi Polytechnic of Construction and Technology, Nanning (China)] [Guangxi Polytechnic of Construction and Technology, Nanning (China); Zuo, Li [Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, Ohio 43210 (United States)] [Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, Ohio 43210 (United States); Chen, Quan [Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22904 (United States)] [Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22904 (United States)

    2014-05-15

    Purpose: Despite superior target dose uniformity, helical tomotherapy{sup ®} (HT) may involve a trade-off between longitudinal dose conformity and beam-on time (BOT), due to the limitation of only three available jaw sizes with the conventional HT (1.0, 2.5, and 5.0 cm). The recently introduced dynamic running-start-stop (RSS) delivery allows smaller jaw opening at the superior and inferior ends of the target when a sharp penumbra is needed. This study compared the dosimetric performance of RSS delivery with the fixed jaw HT delivery. Methods: Twenty patient cases were selected and deidentified prior to treatment planning, including 16 common clinical cases (brain, head and neck (HN), lung, and prostate) and four special cases of whole brain with hippocampus avoidance (WBHA) that require a high degree of dose modulation. HT plans were generated for common clinical cases using the fixed 2.5 cm jaw width (HT2.5) and WBHA cases using 1.0 cm (HT1.0). The jaw widths for RSS were preset with a larger size (RSS5.0 vs HT2.5 and RSS2.5 vs HT1.0). Both delivery techniques were planned based on identical contours, prescriptions, and planning objectives. Dose indices for targets and critical organs were compared using dose-volume histograms, BOT, and monitor units. Results: The average BOT was reduced from 4.8 min with HT2.5 to 2.5 min with RSS5.0. Target dose homogeneity with RSS5.0 was shown comparable to HT2.5 for common clinical sites. Superior normal tissue sparing was observed in RSS5.0 for optic nerves and optic chiasm in brain and HN cases. RSS5.0 demonstrated improved dose sparing for cord and esophagus in lung cases, as well as penile bulb in prostate cases. The mean body dose was comparable for both techniques. For the WBHA cases, the target homogeneity was significantly degraded in RSS2.5 without distinct dose sparing for hippocampus, compared to HT1.0. Conclusions: Compared to the fixed jaw HT delivery, RSS combined with a larger jaw width provides faster treatment delivery and improved cranial-caudal target dose conformity. The target coverage achieved by RSS with a large jaw width is comparable to the fixed jaw HT delivery for common cancer sites, but may deteriorate for cases where complex geometry is present in the middle part of the target.

  17. Analysis of Assembly Bill 310: Prescription Drugs

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01

    pdf. Accessed February 2011. Medco. 2010 Drug Trend Report.www.drugtrend.com/art/drug_trend/pdf/DT_Report_2010.pdf.chronic myeloid leukaemia. Drugs. 2007;67(2): p. 299- April

  18. Prescription Drug List effective January 1, 2015

    E-Print Network [OSTI]

    Arnold, Jonathan

    1 Your 2015 Prescription Drug List effective January 1, 2015 Student Resources Traditional ThreeZIPcode. ·Lookuppossiblelower-costmedicationalternatives. ·Comparemedicationpricingandoptions. #12;2 Your Prescription Drug List This Prescription Drug List (PDL) outlines the most commonly prescribed medications for certain

  19. Drug-Drug Interaction Detection: A New Approach Based on Maximal Frequent Sequences

    E-Print Network [OSTI]

    Rosso, Paolo

    Drug-Drug Interaction Detection: A New Approach Based on Maximal Frequent Sequences Detecci´on de´armacos, extracci´on de relaciones, secuencias frecuentes maximales Abstract: In this paper, a new approach for Drug-Drug that contain Drug-Drug Interactions. Maximal Frequent Sequences define word sequences that are frequent

  20. Health Advisor An Online Game for Managing Healthcare Delivery

    E-Print Network [OSTI]

    Li, Mo

    Health Advisor An Online Game for Managing Healthcare Delivery Tennenbaum Institute Georgia, valuable change. Health Advisor The Tennenbaum Institute is developing, with partial support from IBM, an online game for managing healthcare delivery ­ Health Advisor. Each player manages a set of clients

  1. Nanodiamond as a vector for siRNA delivery to Ewing sarcoma cells

    E-Print Network [OSTI]

    Alhaddad, Anna; Botsoa, Jacques; Dantelle, Géraldine; Perruchas, Sandrine; Gacoin, Thierry; Mansuy, Christelle; Lavielle, Solange; Malvy, Claude; Treussart, François; Bertrand, Jean-Rémi

    2011-01-01

    We investigated the ability of diamond nanoparticles (nanodiamonds, NDs) to deliver small interfering RNA (siRNA) in Ewing sarcoma cells, in the perspective of in vivo anti-cancer nucleic acid drug delivery. siRNA was adsorbed onto NDs previously coated with cationic polymer. Cell uptake of NDs has been demonstrated by taking advantage of NDs intrinsic fluorescence coming from embedded color center defects. Cell toxicity of these coated NDs was shown to be low. Consistent with the internalization efficacy, we have shown a specific inhibition of EWS/Fli-1 gene expression at the mRNA and protein level by the ND vectorized siRNA in a serum containing medium.

  2. IEEE TRANSACTIONS ON POWER DELIVERY, VOL. 24, NO. 2, APRIL 2009 961 Estimates of Comparative Costs for

    E-Print Network [OSTI]

    Baldick, Ross

    IEEE TRANSACTIONS ON POWER DELIVERY, VOL. 24, NO. 2, APRIL 2009 961 Estimates of Comparative Costs, we estimate the costs of increasing trans- mission system capability through technologies for uprating trans- mission capacity without expanding the transmission footprint. We compare costs

  3. U.S. Department of Energy Office of Electricity Delivery & Energy...

    Office of Environmental Management (EM)

    Department of Energy Office of Electricity Delivery & Energy Reliability: Transmission Reliability Program U.S. Department of Energy Office of Electricity Delivery & Energy...

  4. Fabrication of Microporous Thin Films from Polyelectrolyte Multilayers

    E-Print Network [OSTI]

    Barrett, Christopher

    , are established biomaterials finding application as drug delivery systems, enteric coatings for drugs, dental and biomaterial applications. Introduction The fabrication of polyelectrolyte multilayer thin films has received

  5. HYDROGEN PRODUCTION AND DELIVERY INFRASTRUCTURE AS A COMPLEX ADAPTIVE SYSTEM

    SciTech Connect (OSTI)

    Tolley, George S

    2010-06-29

    An agent-based model of the transition to a hydrogen transportation economy explores influences on adoption of hydrogen vehicles and fueling infrastructure. Attention is given to whether significant penetration occurs and, if so, to the length of time required for it to occur. Estimates are provided of sensitivity to numerical values of model parameters and to effects of alternative market and policy scenarios. The model is applied to the Los Angeles metropolitan area In the benchmark simulation, the prices of hydrogen and non-hydrogen vehicles are comparable. Due to fuel efficiency, hydrogen vehicles have a fuel savings advantage of 9.8 cents per mile over non-hydrogen vehicles. Hydrogen vehicles account for 60% of new vehicle sales in 20 years from the initial entry of hydrogen vehicles into show rooms, going on to 86% in 40 years and reaching still higher values after that. If the fuel savings is 20.7 cents per mile for a hydrogen vehicle, penetration reaches 86% of new car sales by the 20th year. If the fuel savings is 0.5 cents per mile, market penetration reaches only 10% by the 20th year. To turn to vehicle price difference, if a hydrogen vehicle costs $2,000 less than a non-hydrogen vehicle, new car sales penetration reaches 92% by the 20th year. If a hydrogen vehicle costs $6,500 more than a non-hydrogen vehicle, market penetration is only 6% by the 20th year. Results from other sensitivity runs are presented. Policies that could affect hydrogen vehicle adoption are investigated. A tax credit for the purchase of a hydrogen vehicle of $2,500 tax credit results in 88% penetration by the 20th year, as compared with 60% in the benchmark case. If the tax credit is $6,000, penetration is 99% by the 20th year. Under a more modest approach, the tax credit would be available only for the first 10 years. Hydrogen sales penetration then reach 69% of sales by the 20th year with the $2,500 credit and 79% with the $6,000 credit. A carbon tax of $38 per metric ton is not large enough to noticeably affect sales penetration. A tax of $116 per metric ton makes centrally produced hydrogen profitable in the very first year but results in only 64% penetration by year 20 as opposed to the 60% penetration in the benchmark case. Provision of 15 seed stations publicly provided at the beginning of the simulation, in addition to the 15 existing stations in the benchmark case, gives sales penetration rates very close to the benchmark after 20 years, namely, 63% and 59% depending on where they are placed.

  6. Ibid-CaltechLibrarySystem Electronic Delivery Cover Sheet

    E-Print Network [OSTI]

    Rosakis, Ares J.

    The copyright law of the United States (Title 17, United States Code) governs the making of photocopies or other Ltd. All rights reserved. PII: S0022-5096(02)00082-0 #12;426 D. Coker et al. / J. Mech. Phys. Solids

  7. Ibid-CaltechLibrarySystem Electronic Delivery Cover Sheet

    E-Print Network [OSTI]

    Rosakis, Ares J.

    The copyright law of the United States (Title 17, United States Code) governs the making of photocopies or other of intersonic crack growth in asymmetrically loaded unidirectional composite plates Demirkan Coker{ and Ares J

  8. Development of a Safe Gene Delivery System Using Biodegradable Polymer,

    E-Print Network [OSTI]

    Park, Jong-Sang

    -L-lysine into a hydroxyl group (Scheme 1). Polymerization of the monomer was conducted in the melt to make polymer 2 as the polymer was synthesized in the melt. Cbz groups protecting -amines were removed and the resulting primary amine groups of PAGA were obtained as a hydrochloride salt. The molecular weight distribution (MWD

  9. Urban Sewage Delivery Heat Transfer System (2): Heat Transfer 

    E-Print Network [OSTI]

    Zhang, C.; Wu, R.; Li, X.; Li, G.; Zhuang, Z.; Sun, D.

    2006-01-01

    analysis of above flow resistance and energy cost, we know that the economy flux ratio of transfer heat-transfer means is between 0.54 and 0.85, namely sewage flux is smaller, and minC Cr min wwCVc?= . It is necessary to point out that though depending... efficiency of contranatant two pass thimble: ()213 1 11 21wwNn wz tt Cr tt 1n? ?? ?==?+ ? (1) Fig.1 Reverse-flow heat efficiency of TDHTS Contranatant single pass heat-transfer efficiency: ( ) ()1 1exp (1 ) 1exp (1)n Cr NTU Cr? = ?? ? ? Put...

  10. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Environmental Management (EM)

    - James Nutaro, ORNL.pdf CEDS 2010 Peer Review - Lemnos Interoperable Security - Brian Smith, EnerNex.pdf CEDS 2010 Peer Review - Trustworthy Wireless for Critical Infrastructure...

  11. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Environmental Management (EM)

    INL.pdf CEDS 2010 Peer Review - Hallmark Cryptographic Serial Communication - Rhett Smith, Schweitzer Engineering.pdf CEDS 2010 Peer Review - SSCP Commercialization - Mark...

  12. Refuse derived fuel delivery system and distribution conveyors

    SciTech Connect (OSTI)

    Kaminski, D.J.; Frank, E.A.; Grinsteiner, C.S.

    1987-08-18

    This patent describes an apparatus for supplying comminuted combustible solid waste material from a refuse material supply to a combustion apparatus for use as fuel and wherein the combustion apparatus includes at least two fuel charging means each having a hopper for receiving comminuted combustible solid waste material, and the hoppers being positioned in side-by-side relation.

  13. Ammonia storage and delivery systems for NOx aftertreatment

    Broader source: Energy.gov [DOE]

    Poster presenation at the 2007 Diesel Engine-Efficiency & Emissions Research Conference (DEER 2007). 13-16 August, 2007, Detroit, Michigan. Sponsored by the U.S. Department of Energy's (DOE) Office of FreedomCAR and Vehicle Technologies (OFCVT).

  14. Background Paper on E-cigarettes (Electronic Nicotine Delivery Systems)

    E-Print Network [OSTI]

    Grana, Rachel PhD, MPH; Benowitz, Neal MD; Glantz, Stanton A. PhD

    2013-01-01

    B. 2010. Identification of amino-tadalafil and rimonabant inflavor contained amino-tadalafil and rimonabant, medicines

  15. "Working to upgrade electrical generation and delivery systems."

    E-Print Network [OSTI]

    Zhigilei, Leonid V.

    . Applications include video distribution in CATV service, replacement of point-to-point microwave links, interconnects for phased-array antennas, and links to antennas for microwave transmission. To date, we have, we have established a solar cell program. We work with chemists, who synthesize new materials

  16. Particulate Carrier Systems for Mucosal DNA Vaccine Delivery

    E-Print Network [OSTI]

    Borchard, Gerrit

    2006-10-26

    Streptomyces griseus Stop solution: 1M KOH In humans: degradation by lysozyme Incubation with chitosanase (1) GPEN 2006 Free DNA chitoplexes Incubation with chitosanase, 37?C Intact DNA ? Degraded chitosan Intact DNA ? Extraction with phenol: chloroform... Streptomyces griseus Stop solution: 1M KOH In humans: degradation by lysozyme Incubation with chitosanase (1) GPEN 2006 Free DNA chitoplexes Incubation with chitosanase, 37?C Intact DNA ? Degraded chitosan Intact DNA ? Extraction with phenol: chloroform...

  17. Comments of Cisco Systems to Office of Electricity Delivery and...

    Energy Savers [EERE]

    of the Energy Independence and Security Act (EISA) of 2007 A POLICY FRAMEWORK FOR THE 21st CENTURY GRID: Enabling Our Secure Energy Future Association of Home Appliance...

  18. Patch and Update Management Program for Energy Delivery Systems

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy Bills andOrder 422.1, CONDUCT P -Particle ReceiverEnergyInformation

  19. Cybersecurity for Energy Delivery Systems (CEDS) Fact Sheets | Department

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomer Service HandbookCSPM is eitherAnof

  20. Cybersecurity for Energy Delivery Systems (CEDS) Research Call | Department

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomer Service HandbookCSPM is

  1. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomer Service HandbookCSPM isBest

  2. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomer Service HandbookCSPM isBestBest

  3. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomer Service HandbookCSPM

  4. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomer Service HandbookCSPMSoftware

  5. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomer Service

  6. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomer ServiceVisualization and Modeling |

  7. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomer ServiceVisualization and Modeling

  8. Microcalibrator system for chemical signature and reagent delivery.

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(JournalspectroscopyReport) |(Patent) | SciTechSciTechConnect(Technical Report) |

  9. Tank Waste Feed Delivery System Readiness at the Hanford Site

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergyPlan | DepartmentXIII--SMART GRID SEC.QuadrennialTank Farms at18/10 TankAudit

  10. Vulnerability Analysis of Energy Delivery Control Systems (September 2011)

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LIST OF APPLICABLEStatutoryinEnableVisualization &IdahoLLCVote for

  11. Vulnerability Analysis of Energy Delivery Control Systems - 2011 |

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LIST OF APPLICABLEStatutoryinEnableVisualization &IdahoLLCVote forDepartment of

  12. Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 |

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirley Ann JacksonDepartment of EnergyResearchers at the Energyone in every three

  13. Cybersecurity for Energy Delivery Systems 2010 Peer Review | Department of

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergy A plug-in electric vehicle (PEV)Day-June2012environmentThe Department ofOctober

  14. Drug-Target Interaction Predicates Combining Similarities

    E-Print Network [OSTI]

    Daume III, Hal

    Drug-Target Interaction Predicates DataSet Combining Similarities Collective Inference Collective Inference and Multi-Relational Learning for Drug­Target Interaction Prediction Shobeir Fakhraei1, Bert Huang1 and Lise Getoor1,2 Poly-pharmacology Drug Repurposing Drug-Target Interaction Network Studies

  15. Target isolation system, high power laser and laser peening method and system using same

    DOE Patents [OSTI]

    Dane, C. Brent (Livermore, CA); Hackel, Lloyd A. (Livermore, CA); Harris, Fritz (Rocklin, CA)

    2007-11-06

    A system for applying a laser beam to work pieces, includes a laser system producing a high power output beam. Target delivery optics are arranged to deliver the output beam to a target work piece. A relay telescope having a telescope focal point is placed in the beam path between the laser system and the target delivery optics. The relay telescope relays an image between an image location near the output of the laser system and an image location near the target delivery optics. A baffle is placed at the telescope focal point between the target delivery optics and the laser system to block reflections from the target in the target delivery optics from returning to the laser system and causing damage.

  16. Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic

    E-Print Network [OSTI]

    Daume III, Hal

    Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic Shobeir, USA getoor@cs.umd.edu ABSTRACT The high development cost and low success rate of drug dis- covery from appro- ved drugs. Computational methods can be effective in focu- sing efforts for such drug repurposing

  17. Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates to paclitaxel and the subsequent ring-opening polymerization of lactide. The drug-initiated, controlled(-caprolactone)) was also achieved through drug/(BDI-II)ZnN(TMS)2-mediated controlled polymerization. These drug

  18. Alcohol and Other Drugs -1 -Approved: 05/09/2014 Alcohol and Other Drugs

    E-Print Network [OSTI]

    Hammack, Richard

    Alcohol and Other Drugs - 1 - Approved: 05/09/2014 Alcohol and Other Drugs Policy Type: Board with the federal Drug Free Workplace Act of 1988, the federal Drug Free Schools and Communities Act of 1989, and the Commonwealth of Virginia's Policy on Alcohol and Other Drugs (AOD), it is the policy of Virginia Commonwealth

  19. Dynamic Line Rating Oncor Electric Delivery Smart Grid Program

    SciTech Connect (OSTI)

    Johnson, Justin; Smith, Cale; Young, Mike; Donohoo, Ken; Owen, Ross; Clark, Eddit; Espejo, Raul; Aivaliotis, Sandy; Stelmak, Ron; Mohr, Ron; Barba, Cristian; Gonzalez, Guillermo; Malkin, Stuart; Dimitrova, Vessela; Ragsdale, Gary; Mitchem, Sean; Jeirath, Nakul; Loomis, Joe; Trevino, Gerardo; Syracuse, Steve; Hurst, Neil; Mereness, Matt; Johnson, Chad; Bivens, Carrie

    2013-05-04

    Electric transmission lines are the lifeline of the electric utility industry, delivering its product from source to consumer. This critical infrastructure is often constrained such that there is inadequate capacity on existing transmission lines to efficiently deliver the power to meet demand in certain areas or to transport energy from high-generation areas to high-consumption regions. When this happens, the cost of the energy rises; more costly sources of power are used to meet the demand or the system operates less reliably. These economic impacts are known as congestion, and they can amount to substantial dollars for any time frame of reference: hour, day or year. There are several solutions to the transmission constraint problem, including: construction of new generation, construction of new transmission facilities, rebuilding and reconductoring of existing transmission assets, and Dynamic Line Rating (DLR). All of these options except DLR are capital intensive, have long lead times and often experience strong public and regulatory opposition. The Smart Grid Demonstration Program (SGDP) project co-funded by the Department of Energy (DOE) and Oncor Electric Delivery Company developed and deployed the most extensive and advanced DLR installation to demonstrate that DLR technology is capable of resolving many transmission capacity constraint problems with a system that is reliable, safe and very cost competitive. The SGDP DLR deployment is the first application of DLR technology to feed transmission line real-time dynamic ratings directly into the system operation’s State Estimator and load dispatch program, which optimizes the matching of generation with load demand on a security, reliability and economic basis. The integrated Dynamic Line Rating (iDLR)1 collects transmission line parameters at remote locations on the lines, calculates the real-time line rating based on the equivalent conductor temperature, ambient temperature and influence of wind and solar radiation on the stringing section, transmits the data to the Transmission Energy Management System, validates its integrity and passes it on to Oncor and ERCOT (Electric Reliability Council of Texas) respective system operations. The iDLR system is automatic and transparent to ERCOT System Operations, i.e., it operates in parallel with all other system status telemetry collected through Supervisory Control and Data Acquisition (SCADA) employed across the company.

  20. Self-assembled thin films with tunable release kinetics for biomedical applications

    E-Print Network [OSTI]

    Hsu, Bryan Boen

    2014-01-01

    The appropriate drug delivery approach is critical to therapeutic success without causing serious harm. Systemic delivery is a common method for delivering drugs but high dosages are needed to maintain elevated plasma ...

  1. Designing nanoparticles for highly efficient endothelial siRNA delivery

    E-Print Network [OSTI]

    Dahlman, James E

    2015-01-01

    RNA potently regulates gene expression. However, the utility of RNA has been limited by the ability to efficiently deliver it to specific cells in vivo. In vivo RNA delivery is challenging; vehicles must avoid phagocytosis ...

  2. Intelligent Matchmaking for Polar Ice Sheet Data Collection and Delivery

    E-Print Network [OSTI]

    Kansas, University of

    for the dynamic configuration of sensors and the motion of the rovers that carry them. The PRISM intelligent intelligent sensor and roveIntelligent Matchmaking for Polar Ice Sheet Data Collection and Delivery Costas Tsatsoulis, Sudha

  3. OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY (OE)

    Office of Environmental Management (EM)

    Saipan via barge to assist with restoration efforts. Severe damage U.S. Department of Energy Situation Report U.S. Department of Energy Office of Electricity Delivery & Energy...

  4. Design of an underwater vertical glider for subsea equipment delivery

    E-Print Network [OSTI]

    Ambler, Charles Kirby

    2010-01-01

    Delivery of subsea equipment and sensors is generally accomplished with unguided sinking platforms or powered autonomous underwater vehicles (AUVs). An alternative would be to augment existing platforms with navigation and ...

  5. Vehicle Technologies Office - AVTA: All Electric Delivery Trucks...

    Broader source: Energy.gov (indexed) [DOE]

    of reports (part of the medium and heavy-duty truck data) describes data collected from Smith Newton all-electric delivery trucks in a variety of fleets. This research was...

  6. DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project...

    Broader source: Energy.gov (indexed) [DOE]

    February 8-9, 2005, the Department of Energy held the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting at Argonne National Laboratory. The purpose of...

  7. Joint Architecture Standard (JAS) Reliable Data Delivery Protocol (RDDP) specification.

    SciTech Connect (OSTI)

    Enderle, Justin Wayne; Daniels, James W.; Gardner, Michael T.; Eldridge, John M.; Hunt, Richard D.; Gallegos, Daniel E.

    2011-05-01

    The Joint Architecture Standard (JAS) program at Sandia National Laboratories requires the use of a reliable data delivery protocol over SpaceWire. The National Aeronautics and Space Administration at the Goddard Spaceflight Center in Greenbelt, Maryland, developed and specified a reliable protocol for its Geostationary Operational Environment Satellite known as GOES-R Reliable Data Delivery Protocol (GRDDP). The JAS program implemented and tested GRDDP and then suggested a number of modifications to the original specification to meet its program specific requirements. This document details the full RDDP specification as modified for JAS. The JAS Reliable Data Delivery Protocol uses the lower-level SpaceWire data link layer to provide reliable packet delivery services to one or more higher-level host application processes. This document specifies the functional requirements for JRDDP but does not specify the interfaces to the lower- or higher-level processes, which may be implementation-dependent.

  8. Optimal Multi-Temperature delivery frequency for small format stores

    E-Print Network [OSTI]

    Barooah, Mayurpankhi

    2015-01-01

    Retailers are exploring more efficient ways to deliver to small format stores that demand frequent and small volume deliveries from Distribution Centers. The need to deliver products at different temperatures, viz. Ambient, ...

  9. Vacancy Announcements Posted for Hydrogen Production and Delivery Program

    Broader source: Energy.gov [DOE]

    The Fuel Cell Technologies Office has posted two vacancy announcements for a position to serve as Program Manager for the Hydrogen Production and Delivery Program in the DOE EERE Fuel Cell Technologies Office. The closing date is October 28, 2014.

  10. Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions

    E-Print Network [OSTI]

    Macdonald, Mara Lee

    2010-01-01

    This thesis focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer ...

  11. Evaluating Feed Delivery Performance in Scaled Double-Shell Tanks

    SciTech Connect (OSTI)

    Lee, Kearn P.; Thien, Michael G.

    2013-11-07

    The Hanford Tank Operations Contractor (TOC) and the Hanford Waste Treatment and Immobilization Plant (WTP) contractor are both engaged in demonstrating mixing, sampling, and transfer system capability using simulated Hanford High-Level Waste (HLW) formulations. This work represents one of the remaining technical issues with the high-level waste treatment mission at Hanford. The TOCs' ability to adequately mix and sample high-level waste feed to meet the WTP WAC Data Quality Objectives must be demonstrated. The tank mixing and feed delivery must support both TOC and WTP operations. The tank mixing method must be able to remove settled solids from the tank and provide consistent feed to the WTP to facilitate waste treatment operations. Two geometrically scaled tanks were used with a broad spectrum of tank waste simulants to demonstrate that mixing using two rotating mixer jet pumps yields consistent slurry compositions as the tank is emptied in a series of sequential batch transfers. Testing showed that the concentration of slow settling solids in each transfer batch was consistent over a wide range of tank operating conditions. Although testing demonstrated that the concentration of fast settling solids decreased by up to 25% as the tank was emptied, batch-to-batch consistency improved as mixer jet nozzle velocity in the scaled tanks increased.

  12. Drug Trafficking Organizations and Counter-Drug Strategies in the U.S.-Mexican Context

    E-Print Network [OSTI]

    Astorga, Luis; Shirk, David A.

    2010-01-01

    Analytic Assessment of U.S. Drug Policy. Washington, D.C. ,K. (2008). Mexico Faces New Drug Challenge: Mini-Submarines.Mayors on Front Line of the Drug War. Los Angeles Times Los

  13. Two-dimensional inverse planning and delivery with a preclinical image guided microirradiator

    SciTech Connect (OSTI)

    Stewart, James M. P.; Lindsay, Patricia E.; Jaffray, David A.; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9; Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2; Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9; The Techna Institute for the Advancement of Technology for Health, Toronto, Ontario M5G 1P5

    2013-10-15

    Purpose: Recent advances in preclinical radiotherapy systems have provided the foundation for scaling many of the elements of clinical radiation therapy practice to the dimensions and energy demanded in small animal studies. Such systems support the technical capabilities to accurately deliver highly complex dose distributions, but methods to optimize and deliver such distributions remain in their infancy. This study developed an optimization method based on empirically measured two-dimensional dose kernel measurements to deliver arbitrary planar dose distributions on a recently developed small animal radiotherapy platform.Methods: A two-dimensional dose kernel was measured with repeated radiochromic film measurements for the circular 1 mm diameter fixed collimator of the small animal radiotherapy system at 1 cm depth in a solid water phantom. This kernel was utilized in a sequential quadratic programming optimization framework to determine optimal beam positions and weights to deliver an arbitrary desired dose distribution. The positions and weights were then translated to a set of stage motions to automatically deliver the optimized dose distribution. End-to-end efficacy of the framework was quantified through five repeated deliveries of two dosimetric challenges: (1) a 5 mm radius bullseye distribution, and (2) a “sock” distribution contained within a 9 × 13 mm bounding box incorporating rectangular, semicircular, and exponentially decaying geometric constructs and a rectangular linear dose gradient region. These two challenges were designed to gauge targeting, geometric, and dosimetric fidelity.Results: Optimization of the bullseye and sock distributions required 2.1 and 5.9 min and utilized 50 and 77 individual beams for delivery, respectively. Automated delivery of the resulting optimized distributions, validated using radiochromic film measurements, revealed an average targeting accuracy of 0.32 mm, and a dosimetric delivery error along four line profiles taken through the sock distribution of 3.9%. Mean absolute delivery error across the 0–1 Gy linear dose gradient over 7.5 mm was 0.01 Gy.Conclusions: The work presented here demonstrates the potential for complex dose distributions to be planned and automatically delivered with millimeter scale heterogeneity at submillimeter accuracy. This capability establishes the technical foundation for preclinical validation of biologically guided radiotherapy investigations and development of unique radiobiological experiments.

  14. Managing Faults in the Service Delivery Process of Service Provider Coalitions Patricia Marcu

    E-Print Network [OSTI]

    processes of ITSM are critical for successful delivery as stressed by the IT Infrastructure Library (ITIL

  15. Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery (Presentation)

    SciTech Connect (OSTI)

    Jalalzadeh-Azar, A.

    2010-10-18

    This presentation summarizes "A Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery".

  16. IDC System Specification Document.

    SciTech Connect (OSTI)

    Clifford, David J.

    2014-12-01

    This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris

  17. Record of Categorical Exclusion (CX) Office of Electricity Delivery and

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested PartiesBuildingBudget ||DepartmentReadoutReview ofDeliveryDeliveryEnergy

  18. R&D program benefits estimation: DOE Office of Electricity Delivery and Energy Reliability

    SciTech Connect (OSTI)

    None, None

    2006-12-04

    The overall mission of the U.S. Department of Energy’s Office of Electricity Delivery and Energy Reliability (OE) is to lead national efforts to modernize the electric grid, enhance the security and reliability of the energy infrastructure, and facilitate recovery from disruptions to the energy supply. In support of this mission, OE conducts a portfolio of research and development (R&D) activities to advance technologies to enhance electric power delivery. Multiple benefits are anticipated to result from the deployment of these technologies, including higher quality and more reliable power, energy savings, and lower cost electricity. In addition, OE engages State and local government decision-makers and the private sector to address issues related to the reliability and security of the grid, including responding to national emergencies that affect energy delivery. The OE R&D activities are comprised of four R&D lines: High Temperature Superconductivity (HTS), Visualization and Controls (V&C), Energy Storage and Power Electronics (ES&PE), and Distributed Systems Integration (DSI).

  19. Brain science, addiction and drugs

    E-Print Network [OSTI]

    Wiesner, Karoline

    Designing your future Page 7 Theme: Nanoscience and Quantum Information Exchanging keys in the Canaries Page:searchUniversity of Bristol · Research Review · Issue 10 · October 2005 research themes issue #12;Research themes 2005 Establishedresearchthemes Theme: Neuroscience Brain science, addiction and drugs Other established research themes

  20. Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor

    E-Print Network [OSTI]

    Gates, Kent. S.

    the complexity and challenges encountered in the drug discovery process. 50 ACCOUNTS OF CHEMICAL RESEARCH 50Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor cell culture system and the absence of a convenient small animal model have hampered the assessment

  1. User & situation models for medical information delivery 

    E-Print Network [OSTI]

    Francisco-Revilla, Luis

    1998-01-01

    , the utilization of user and situation models, the separation of the presentation from the information itself, and the system's role of an assistant. The system architecture is based on a client-server model using Object Oriented Programming. The system is divided...

  2. Separate lubricating system for marine propulsion device

    SciTech Connect (OSTI)

    Matsumoto, K.

    1986-02-25

    This patent describes a lubricating system for a two-cycle internal combustion engine. This system consists of a relatively large remotely positioned lubricant storage tank a relatively small lubricant delivery tank positioned in proximity to the engine for delivering lubricant to its lubricating system and means responsive to the level of lubricant in the delivery tank for transferring lubricant to maintain a predetermined level of lubricant in the delivery tank. The improvement consists of means for providing a warning signal when the level of lubricant in the storage tank falls below a predetermined amount. The means for providing the warning signal operate further to discontinue the transfer of lubricant from the storage tank to the delivery tank. There also is a manual override for operating the means for transferring lubricant from the storage tank to the delivery tank under operator control even when the warning signal has been activated.

  3. Financing drug discovery for orphan diseases

    E-Print Network [OSTI]

    Fagnan, David Erik

    Recently proposed ‘megafund’ financing methods for funding translational medicine and drug development require billions of dollars in capital per megafund to de-risk the drug discovery process enough to issue long-term ...

  4. Cell-penetrating DNA-binding protein as a safe and efficient naked DNA delivery carrier in vitro and in vivo

    SciTech Connect (OSTI)

    Kim, Eun-Sung; Yang, Seung-Woo; Hong, Dong-Ki; Kim, Woo-Taek; Kim, Ho-Guen; Lee, Sang-Kyou

    2010-01-29

    Non-viral gene delivery is a safe and suitable alternative to viral vector-mediated delivery to overcome the immunogenicity and tumorigenesis associated with viral vectors. Using the novel, human-origin Hph-1 protein transduction domain that can facilitate the transduction of protein into cells, we developed a new strategy to deliver naked DNA in vitro and in vivo. The new DNA delivery system contains Hph-1-GAL4 DNA-binding domain (DBD) fusion protein and enhanced green fluorescent protein (EGFP) reporter plasmid that includes the five repeats of GAL4 upstream activating sequence (UAS). Hph-1-GAL4-DBD protein formed complex with plasmid DNA through the specific interaction between GAL4-DBD and UAS, and delivered into the cells via the Hph-1-PTD. The pEGFP DNA was successfully delivered by the Hph-1-GAL4 system, and the EGFP was effectively expressed in mammalian cells such as HeLa and Jurkat, as well as in Bright Yellow-2 (BY-2) plant cells. When 10 {mu}g of pEGFP DNA was intranasally administered to mice using Hph-1-GAL4 protein, a high level of EGFP expression was detected throughout the lung tissue for 7 days. These results suggest that an Hph-1-PTD-mediated DNA delivery strategy may be an useful non-viral DNA delivery system for gene therapy and DNA vaccines.

  5. The pipeline and future of drug development in schizophrenia

    E-Print Network [OSTI]

    Gray, J A; Roth, B L

    2007-01-01

    The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

  6. Drug transport in brain via the cerebrospinal fluid

    E-Print Network [OSTI]

    Pardridge, William M

    2011-01-01

    diffusion. Drug transport into cerebrospinal fluid vs. brainDrug transport from blood to interstitial fluid (ISF) isDrug transport in brain via the cerebrospinal fluid William

  7. Predicting new molecular targets for known drugs

    E-Print Network [OSTI]

    Kaski, Samuel

    ARTICLES Predicting new molecular targets for known drugs Michael J. Keiser1,2 *, Vincent Setola3 drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug­target combinations exist, it would be useful to explore possible

  8. CMVO Drug Testing Program Reasonable Suspicion Testing

    E-Print Network [OSTI]

    Sin, Peter

    CMVO Drug Testing Program Reasonable Suspicion Testing CMVO Revised Suspicion Form (Revised 6/08) Guidelines for Reasonable Suspicion Drug and Alcohol Testing: A supervisor, trained in accordance with 49 CFR involved in an incident that requires drug/alcohol testing as set forth in 382.307. Remember: Reasonable

  9. Focus Article Open challenges in magnetic drug

    E-Print Network [OSTI]

    Shapiro, Benjamin

    Focus Article Open challenges in magnetic drug targeting Benjamin Shapiro,1,2 Sandip Kulkarni,1 Aleksander Nacev,3 Silvia Muro,1,4 Pavel Y. Stepanov3 and Irving N. Weinberg3 The principle of magnetic drug is that highlight- ing these challenges will help researchers translate magnetic drug targeting from a novel concept

  10. Drugs and Behavior (Psychology 320 Sec. 001)

    E-Print Network [OSTI]

    Hopfinger, Joseph B.

    1 Drugs and Behavior (Psychology 320 Sec. 001) Syllabus Example Text: Maisto, Galizio and Conners. Drug Use and Abuse. Harcourt Brace College Publishers. 2008, Fifth Edition. Prerequisites: This course of drugs of abuse. An overview of basic pharmacology and behavioral pharmacology will be provided followed

  11. Process management applications in biopharmaceutical drug production

    E-Print Network [OSTI]

    Smith, Stephen E

    2011-01-01

    Genzyme's manufacturing and supply chain organization is responsible for the production and delivery of medically necessary medicines for patients with rare diseases around the world. Because of the nature of the products ...

  12. Proctors' Memorandum on Drugs Misuse Guidelines from Proctors' Office on Dealing with Drugs Misuse

    E-Print Network [OSTI]

    Henderson, Gideon

    Proctors' Memorandum on Drugs Misuse Guidelines from Proctors' Office on Dealing with Drugs Misuse The use of specified drugs is illegal within the UK, and is inimical to the University's primary objectives of the pursuit of academic study and research. The presence of drugs within the University

  13. Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs

    E-Print Network [OSTI]

    Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs become empowered to share personal experiences regarding prescription drugs via Web page discussion from patient-provided drug reviews on health-related web sites. We focus on the statin class

  14. HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS

    E-Print Network [OSTI]

    Kim, Duck O.

    HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC AND OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS (5/3/2013) Introduction Drugs have a successful history of use in treating diseases and are responsible for many medical advances over the past century. However, virtually every drug has side effects

  15. Policy on Drug-Free Workplace Policy on Drug-Free Workplace

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Drug-Free Workplace 10/26/2014 Policy on Drug-Free Workplace I. Purpose and Scope responsible decision- making regarding the use of alcohol and other drugs. Northeastern strives to maintain drug use can create. Additionally, the University is committed to enforcing policies and laws relating

  16. Drugs in Cinema: Separating the Myths from Reality

    E-Print Network [OSTI]

    Iannicelli, Paul

    2001-01-01

    Drugs in Cinema: Separating the Myths from Reality PaulSUMMARY 7 (2000). DRUGS IN CINEMA policy has a significantviolence in film. DRUGS IN CINEMA III. HISTORY OF DRUG USE

  17. Sci—Fri AM: Mountain — 05: Unified Optimization and Delivery of Intensity-modulated Radiation Therapy and Volume-modulated Arc Therapy

    SciTech Connect (OSTI)

    Chen, J; Hoover, D; MacFarlane, M; Wong, E

    2014-08-15

    Purpose: To study the feasibility of a unified intensity-modulated arc therapy (UIMAT) that combines IMRT and VMAT optimization and delivery in order to produce efficient and superior radiation treatment plans. Methods: Inverse planning for UIMAT was prototyped on the Pinnacle treatment planning system (Philips Medical Systems). UIMAT integrates IMRT and VMAT delivery in the same arc where IMRT was delivered with gantry speed close to zero. Optimal gantry angles for the IMRT phases were selected automatically by the inverse optimization algorithm. Optimization of the VMAT phases and IMRT phases were done simultaneously using Pinnacle's direct machine parameter optimization algorithm. Five treatment plans each for prostate, head and neck, and lung were generated using our unified technique and compared with clinical VMAT or IMRT plans. Delivery verification was performed on an ArcCheck phantom (Sun Nuclear) and delivered in clinical mode on a Varian TrueBeam linear accelerator. Results: In this prototype implementation, compared to the VMAT or IMRT plans, with the plans normalized to the same dose coverage to the planning target volumes, the UIMAT plans produced improved OAR sparing for head and neck cases, while for lung and prostate cases, the dosimetric improvements for OARs were not as significant. In this proof-of-concept work, we demonstrated that a novel radiation therapy delivery technique combining VMAT and IMRT delivery in the same arc is feasible. Initial results showed UIMAT has the potential to be superior to either standard IMRT or VMAT.

  18. Microbial Metabolism Systems Microbiology

    E-Print Network [OSTI]

    Huang, Ching-Tsan

    and bioremediation Bioterrorism and decontamination Microbiological detection systems Global monitoring #12 Evolution Microbial - Host System Multi-Disciplinary Biocontrol/ Bioremediation Drug Discovery Antibiotic Reduced water pollution Antimicrobial Metabolites Reduced pathogens Reduced disease Reduced fungicide

  19. Vaginal mesh grafts and the Food and Drug Administration

    E-Print Network [OSTI]

    Ostergard, Donald R.

    2010-01-01

    and the Food and Drug Administration Donald R. Ostergardthe food and drug administration's (FDA) 510(k) process of

  20. Tank Farms and Waste Feed Delivery - 12507

    SciTech Connect (OSTI)

    Fletcher, Thomas; Charboneau, Stacy; Olds, Erik [US DOE (United States)

    2012-07-01

    The mission of the Department of Energy's Office of River Protection (ORP) is to safely retrieve and treat the 56 million gallons of Hanford's tank waste and close the Tank Farms to protect the Columbia River. Our discussion of the Tank Farms and Waste Feed Delivery will cover progress made to date with Base and Recovery Act funding in reducing the risk posed by tank waste and in preparing for the initiation of waste treatment at Hanford. The millions of gallons of waste are a by-product of decades of plutonium production. After irradiated fuel rods were taken from the nuclear reactors to the processing facilities at Hanford they were exposed to a series of chemicals designed to dissolve away the rod, which enabled workers to retrieve the plutonium. Once those chemicals were exposed to the fuel rods they became radioactive and extremely hot. They also couldn't be used in this process more than once. Because the chemicals are caustic and extremely hazardous to humans and the environment, underground storage tanks were built to hold these chemicals until a more permanent solution could be found. The underground storage tanks range in capacity from 55,000 gallons to more than 1 million gallons. The tanks were constructed with carbon steel and reinforced concrete. There are eighteen groups of tanks, called 'tank farms', some having as few as two tanks and others up to sixteen tanks. Between 1943 and 1964, 149 single-shell tanks were built at Hanford in the 200 West and East Areas. Heat generated by the waste and the composition of the waste caused an estimated 67 of these single-shell tanks to leak into the ground. Washington River Protection Solutions is the prime contractor responsible for the safe management of this waste. WRPS' mission is to reduce the risk to the environment that is posed by the waste. All of the pumpable liquids have been removed from the single-shell tanks and transferred to the double-shell tanks. What remains in the single-shell tanks are solid and semi-solid wastes. Known as salt-cakes, they have the consistency of wet beach sand. Some of the waste resembles small broken ice, or whitish crystals. Because the original pumps inside the tanks were designed to remove only liquid waste, other methods have been developed to reach the remaining waste. Access to the tank waste is through long, typically skinny pipes, called risers, extending out of the tanks. It is through these pipes that crews are forced to send machines and devices into the tanks that are used to break up the waste or push it toward a pump. These pipes range in size from just a few inches to just over a foot in diameter because they were never intended to be used in this manner. As part of the agreement regulating Hanford cleanup, crews must remove at least 99% of the material in every tank on the site, or at least as much waste that can be removed based on available technology. To date, seven single-shell tanks have been emptied, and work is underway in another 10 tanks in preparation for additional retrieval activities. Two barriers have been installed over single-shell tanks to prevent the intrusion of surface water down to the tanks, with additional barriers planned for the future. Single and double-shell tank integrity analyses are ongoing. Because the volume of the waste generated through plutonium production exceeded the capacity of the single-shell tanks, between 1968 and 1986 Hanford engineers built 28 double-shell tanks. These tanks were studied and made with a second shell to surround the carbon steel and reinforced concrete. The double-shell tanks have not leaked any of their waste. (authors)

  1. Delivery, design, and mechanism of antimicrobial peptides

    E-Print Network [OSTI]

    Chau, Tanguy

    2010-01-01

    Each year, 2 million people contract hospital-acquired bacterial infections, which causes the death of 100,000 patients and costs the US healthcare system over $21 billion. These infections have become dangerously resistant ...

  2. Pure Insulin Nanoparticle Agglomerates for Pulmonary Delivery

    E-Print Network [OSTI]

    Bailey, Mark Michael

    2008-04-29

    and inconvenient, often leading to low patient compliance. To overcome this problem, novel formulations of insulin are being investigated, such as inhaled aerosols. Sufficient deposition of powder in the distal regions of the lung to maximize systemic absorption...

  3. Testing Drugs Versus Testing For Drug Use: Private Risk Management in the Shadow of the Criminal Law

    E-Print Network [OSTI]

    MacCoun, Robert J.

    2007-01-01

    Preface: The Varieties of Drug Control at the Dawn of thetbl.1.1. Id. See Peter Reuter, Drug Use Measures: What AreBetween Student Illicit Drug Use and School Drug-Testing

  4. Volatile Delivery to Planets from Water-rich Planetesimals around Low Mass Stars

    E-Print Network [OSTI]

    Ciesla, Fred J; Pascucci, Ilaria; Apai, Daniel

    2015-01-01

    Most models of volatile delivery to accreting terrestrial planets assume that the carriers for water are similar in water content to the carbonaceous chondrites in our Solar System. Here we suggest that the water content of primitive bodies in many planetary systems may actually be much higher, as carbonaceous chondrites have lost some of their original water due to heating from short-lived radioisotopes that drove parent body alteration. Using N-body simulations, we explore how planetary accretion would be different if bodies beyond the water line contained a water mass fraction consistent with chemical equilibrium calculations, and more similar to comets, as opposed to the more traditional water-depleted values. We apply this model to consider planet formation around stars of different masses and identify trends in the properties of Habitable Zone planets and planetary system architecture which could be tested by ongoing exoplanet census data collection. Comparison of such data with the model predicted tren...

  5. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a user of that drug (e.g. it produces a positive result with probability .98 in the case that the tested individual uses the drug) and 90% accurate in the case of a non

  6. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug .98 in the case that the tested individual uses the drug) and 90% accurate in the case of a non it is known that 10% of the entire population uses this drug. You test someone and the test is positive. What

  7. Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery

    E-Print Network [OSTI]

    Alabi, Christopher A.

    Nanoparticle-mediated siRNA delivery is a complex process that requires transport across numerous extracellular and intracellular barriers. As such, the development of nanoparticles for efficient delivery would benefit ...

  8. Cell squeezing : a vector-free microfluidic platform for intracellular delivery of macromolecules

    E-Print Network [OSTI]

    Sharei, Armon R. (Armon Reza)

    2013-01-01

    Intracellular delivery of material is a long-standing challenge for both therapeutic and research applications. Existing technologies rely on a variety of mechanisms to facilitate delivery. Vector-based methods, such as ...

  9. Delivery of proteins in live cells with viral peptides: principles and mechanisms 

    E-Print Network [OSTI]

    Lee, Ya-Jung

    2012-07-16

    Cell-penetrating peptides (CPPs) mediate the delivery of macromolecules across the plasma membrane of live cells. These peptides are therefore important due to the potential of making the delivery of protein probes or therapeutics a routine...

  10. Using Integrated Project Delivery (IPD) to Resolve the Major Construction Project Delay Causes in Saudi Arabia

    E-Print Network [OSTI]

    Alkhalid, Khalid Abdullah

    2011-12-16

    Integrated Project Delivery (IPD) has gained attention in the United States and Europe as an effective delivery method for construction projects. The aim of this research paper is to determine the major causes of delay in projects in Saudi Arabia...

  11. DOE and FreedomCAR and Fuel Partnership Hydrogen Delivery and...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    DOE and FreedomCAR and Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop DOE and FreedomCAR and Fuel Partnership Hydrogen Delivery and On-Board Storage...

  12. DOE Fuel Cell Technologies Office Record 13013: H2 Delivery Cost...

    Energy Savers [EERE]

    3013: H2 Delivery Cost Projections - 2013 DOE Fuel Cell Technologies Office Record 13013: H2 Delivery Cost Projections - 2013 This program record from the U.S. Department of...

  13. Apatite-Polymer Composite Particles for Controlled Delivery of BMP-2

    E-Print Network [OSTI]

    Yong, Tseh-Hwan

    We have developed a versatile delivery platform comprising a novel composite of two biomaterials with proven track records: apatite and poly(lactic-co-glycolic acid) (PLGA). These composites have been tested in the delivery ...

  14. In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles

    E-Print Network [OSTI]

    Miller, Michelle Teresa

    2009-01-01

    Cancer is the collective group of diseases distinguished by uninhibited growth and spread of abnormal cells. It often results in death if the spread is not controlled. Most cancers are treated by surgery, radiation, ...

  15. Mathematical modelling of the use of macrophages as vehicles for drug-delivery to hypoxic tumour sites

    E-Print Network [OSTI]

    angiogenesis. In this paper we outline a modelling approach to characterise macrophage infiltration into early avascular solid tumours, and extensions to study the interaction of these cells with macrophages already of macrophage infiltration and tumour size. Although increased infiltration should be beneficical from the point

  16. Fortifying breast milk Global delivery device

    E-Print Network [OSTI]

    Necula, George

    comfort, lower risk and dramatically lower cost. Our industrial engineers are working alongside campus'S Super hand Fabricating custom prosthetics #12;Dean'sWord noahBerger Low-cost mobile sensing and imaging challenges to today's costly health care system. In college labs, we are seeing explosive growth in compact

  17. Remarks Prepared for Delivery by Secretary of Energy Spencer Abraham

    E-Print Network [OSTI]

    for the enormous amount of work you have been doing on behalf of the world's energy future. And let me recognize be one of those technologies that allows the world to leapfrog the enormous acceleration in future energyRemarks Prepared for Delivery by Secretary of Energy Spencer Abraham ITER Ministerial December 20

  18. SOUTH CAMPUS APARTMENT RESIDENTS Package and Mail Delivery Information

    E-Print Network [OSTI]

    McConnell, Terry

    SOUTH CAMPUS APARTMENT RESIDENTS Package and Mail Delivery Information Upon check-in you mailbox will be labeled with your building number and apartment number. Example: 311 Chinook Dr Apt 4 will be labeled 311-4. Mail is delivered and handled by the United States Postal Service, USPS, for all

  19. The Sustainable Energy Utility (SEU) Model for Energy Service Delivery

    E-Print Network [OSTI]

    Delaware, University of

    95 The Sustainable Energy Utility (SEU) Model for Energy Service Delivery Jason Houck San Francisco to finance, market, and deliver sustainable energy services to energy end-users. This study outlines the concept of a new third-party administrative model, a sustainable energy utility (SEU), with the potential

  20. Information Delivery in Large Wireless Networks with Minimum Energy Expense

    E-Print Network [OSTI]

    Wang, Wenye

    Information Delivery in Large Wireless Networks with Minimum Energy Expense Yi Xu and Wenye Wang in large-scale multihop wireless networks because of the limited energy supplies from batteries. We and strategies that reduce energy consumption in wireless net- works to extend network lifetimes. Examples