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Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Microfabricated injectable drug delivery system  

DOE Patents [OSTI]

A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

2002-01-01T23:59:59.000Z

2

Synthesis and Characterization of a Magnetically Responsive Polymeric Drug Delivery System  

E-Print Network [OSTI]

A magnetic target drug delivery system consisting of biodegradable polymeric microspheres (poly D, L-lactic acid) loaded with magnetite nanoparticles (10-100 nm) and anticancer drug (paclitaxel) was studied. The magnetite ...

Yu, Shi

3

Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs  

E-Print Network [OSTI]

Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

Stauber, Zachary Jason

2012-01-01T23:59:59.000Z

4

Protein encapsulated magnetic carriers for micro/nanoscale drug delivery systems.  

SciTech Connect (OSTI)

Novel methods for drug delivery may be based on nanotechnology using non-invasive magnetic guidance of drug loaded magnetic carriers to the targeted site and thereafter released by external ultrasound energy. The key building block of this system is to successfully synthesize biodegradable, magnetic drug carriers. Magnetic carriers using poly(D,L-lactide-co-glycolide) (PLGA) or poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) as matrix materials were loaded with bovine serum albumin (BSA) by a double-emulsion technique. BSA-loaded magnetic microspheres were characterized for size, morphology, surface charge, and magnetization. The BSA encapsulation efficiency was determined by recovering albumin from the microspheres using dimethyl sulfoxide and 0.05N NaOH/0.5% SDS then quantifying with the Micro-BCA protein assay. BSA release profiles were also determined by the Micro-BCA protein assay. The microspheres had drug encapsulation efficiencies up to 90% depending on synthesis parameters. Particles were spherical with a smooth or porous surface having a size range less than 5 {mu}m. The surface charge (expressed as zeta potential) was near neutral, optimal for prolonged intravascular survival. The magnetization of these BSA loaded magnetic carriers was 2 to 6 emu/g, depending on the specific magnetic materials used during synthesis.

Xie, Y.; Kaminski, M. D.; Mertz, C. J.; Finck, M. R.; Guy, S. G.; Chen, H.; Rosengart, A. J.; Chemical Engineering; Univ. of Chicago, Pritzker School of Medicine

2005-01-01T23:59:59.000Z

5

Local Delivery System of Immune Modulating Drug for Unresectable Adenocarcinoma: In Vitro Experimental Study and In Vivo Animal Study  

SciTech Connect (OSTI)

The purpose of the study was to evaluate the efficacy and safety of a developed drug delivery system containing OK-432 through in vitro and animal study. An OK-432-impregnated polycarbonate/polyurethane stent membrane was used to develop a drug delivery system (DDS) enabling the locoregional release of OK-432. Polyethyleneglycol was used as a detergent and porosity generator. The stability of OK-432 in solvent, releasing kinetics of drug, and cytotoxicity of the DDS were evaluated. OK-432-impregnated DDS was implanted in mice in which a human adenocarcinoma cell line was injected and grown in their back. Flow cytometry and enzyme-linked immunosorbent assay were used for quantifying the amount of drug. OK-432 exposed to phosphate-buffered saline and OK-432 exposed to N,N-dimethylacetamide showed similar results on dot graphs and histograms. However, OK-432 exposed to tetrahydrofurane showed different dot graphs and histograms, which means that the antigenicity of the drug was changed. The release rate of OK-432 was maintained at a constant level for 6 weeks. The local delivery of OK-432 was found to have an antitumor effect on a human adenocarcinoma cell line in an animal study, but no effect on this cell line in in vitro cell culture. Histologic examination showed minimal inflammatory reaction in surrounding tissue. Our study shows that local treatment using this OK-432 release system is safe and effective in reducing adenocarcinoma in a mouse model.

Lee, Don Haeng [Inha University, College of Medicine, Department of Internal Medicine (Korea, Republic of); Kang, Sung-Gwon [Seoul National University Bundang Hospital, Department of Diagnostic Radiology (Korea, Republic of)], E-mail: gangsg@radiol.snu.ac.kr; Jeong, Seok [Inha University, College of Medicine, Department of Internal Medicine (Korea, Republic of); Yoon, Chang Jin; Choi, Jung-Ah [Seoul National University Bundang Hospital, Department of Diagnostic Radiology (Korea, Republic of); Byun, Ju Nam [Chosun University, College of Medicine, Department of Radiology (Korea, Republic of); Park, Jae Hyung [Seoul National University Bundang Hospital, Department of Diagnostic Radiology (Korea, Republic of); Lee, Kyu Back [Korea University, College of Medicine, Department of Biomedical Engineering (Korea, Republic of)

2006-10-15T23:59:59.000Z

6

Emergency delivery of Vasopressin from an implantable MEMS rapid drug delivery device  

E-Print Network [OSTI]

An implantable rapid drug delivery device based on micro-electro-mechanical systems (MEMS) technology was designed, fabricated and validated for the in vivo rapid delivery of vasopressin in a rabbit model. In vitro ...

Ho Duc, Hong Linh, 1978-

2009-01-01T23:59:59.000Z

7

Optically generated ultrasound for enhanced drug delivery  

DOE Patents [OSTI]

High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

2002-01-01T23:59:59.000Z

8

Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung  

SciTech Connect (OSTI)

Particulate nanocarriers have been praised for their advantageous drug delivery properties in the lung, such as avoidance of macrophage clearance mechanisms and long residence times. However, instilled non-biodegradable polystyrene nanospheres with small diameters and thus large surface areas have been shown to induce pulmonary inflammation. This study examines the potential of biodegradable polymeric nanoparticles composed of poly(lactic-co-glycolic acid) (PLGA) and the novel PLGA derivative, diethylaminopropylamine polyvinyl alcohol-grafted-poly(lactic-co-glycolic acid) (DEAPA-PVAL-g-PLGA), to provoke inflammatory responses in the murine lung after intratracheal instillation. Lactate dehydrogenase (LDH) release, protein concentration, MIP-2 mRNA induction, and polymorphonucleocyte (PMN) recruitment in the bronchial alveolar lavage fluid (BALF) were used to evaluate an inflammatory response in Balb-C mice. Two sizes of polystyrene (PS) nanospheres (diameters: 75 nm and 220 nm) were included in the study for comparison. All nanoparticle suspensions were instilled at concentrations of 1 {mu}g/{mu}l and 2.5 {mu}g/{mu}l, representative of an estimated 'therapeutic dose' and a concentrated 'dose' of particles. In all experiments, the 75 nm PS particles exhibited elevated responses for the inflammatory markers investigated. In contrast, biodegradable particles of comparable hydrodynamic diameter showed a significantly lower inflammatory response. The most marked differences were observed in the extent of PMN recruitment. While the 75 nm and 220 nm PS nanospheres exhibited 41 and 74% PMN within the total BALF cell population after 24 h, respectively, PMN recruiting in lungs instilled with both types of biodegradable particles did not exceed values of the negative isotonic glucose control. In conclusion, evidence suggests that biodegradable polymeric nanoparticles designed for pulmonary drug delivery may not induce the same inflammatory response as non-biodegradable polystyrene particles of comparable size.

Dailey, L.A. [Department of Pharmaceutics and Biopharmacy, Philipps-University, D-35037 Marburg (Germany)]. E-mail: lea_ann.dailey@kcl.ac.uk; Jekel, N. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Fink, L. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Gessler, T. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Schmehl, T. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Wittmar, M. [Department of Pharmaceutics and Biopharmacy, Philipps-University, D-35037 Marburg (Germany); Kissel, T. [Department of Pharmaceutics and Biopharmacy, Philipps-University, D-35037 Marburg (Germany); Seeger, W. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany)

2006-08-15T23:59:59.000Z

9

Mechanical loading impacts intramuscular drug transport : impact on local drug delivery  

E-Print Network [OSTI]

Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue ...

Wu, Peter I-Kung

2008-01-01T23:59:59.000Z

10

Needle-free drug delivery using shock wave techniques  

E-Print Network [OSTI]

A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

Pavlov, Atanas (Atanas Ivanov)

2006-01-01T23:59:59.000Z

11

A fully implantable intracochlear drug delivery device : development and characterization  

E-Print Network [OSTI]

In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

Swan, Erin Eileen Leary, 1976-

2009-01-01T23:59:59.000Z

12

Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery  

E-Print Network [OSTI]

The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

Tan, Mei Chee

13

Microcapsule drug delivery device for treatment of glioblastoma multiforme  

E-Print Network [OSTI]

Controlled-release drug delivery systems are capable of treating debilitating diseases, including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. ...

Scott, Alexander Wesley

2010-01-01T23:59:59.000Z

14

Optimal periodic control of a drug delivery system Subbarao Varigonda 1  

E-Print Network [OSTI]

drug infusion strategies for maximizing a time averaged measure of drug effect are investigated infusion provides a locally improved average effect compared to steady infusion are characterized using 1­2 hr), as steady infusion leads to nearly complete sup- pression of gonadal function [24

Georgiou, Tryphon T.

15

Drug delivery by organ-specific immunoliposomes  

SciTech Connect (OSTI)

Monoclonal antibodies highly specific to the mouse pulmonary endothelial cells were conjugated to liposomes. The resulting immunoliposomes showed high levels of lung accumulation when injected intravenously into mice. Optimal target binding and retention were achieved if the lipid composition included ganglioside GM{sub 1} to reduce the uptake of immunoliposomes by the reticuloendothelial system. Details of the construction and optimization of these organ-specific immunoliposomes are reviewed. The drug delivery potential of this novel liposome system was demonstrated in an experimental pulmonary metastasis model. Immunoliposomes containing a lipophilic prodrug of deoxyfluorouridine effectively prolonged the survival time of the tumor-bearing mice. This and other therapeutic applications of the immunoliposomes are discussed. 25 refs., 5 figs.

Maruyama, Kazuo; Mori, Atsuhide; Hunag, Leaf (Tennessee Univ., Knoxville, TN (USA). Dept. of Biochemistry); Kennel, S.J. (Oak Ridge National Lab., TN (USA))

1990-01-01T23:59:59.000Z

16

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network [OSTI]

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

17

Controlling drug delivery across the placenta: A commentary  

E-Print Network [OSTI]

A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ...

Audus, Kenneth L.

1999-01-01T23:59:59.000Z

18

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network [OSTI]

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

19

Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery  

SciTech Connect (OSTI)

Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

Saha, Dipendu [ORNL] [ORNL; Warren, Kaitlyn E [ORNL] [ORNL; Naskar, Amit K [ORNL] [ORNL

2014-01-01T23:59:59.000Z

20

Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery  

E-Print Network [OSTI]

Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to ...

Seto, Jennifer Elizabeth

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Transdermal microconduits by microscission for drug delivery and sample acquisition  

E-Print Network [OSTI]

Background Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum ...

Gonzalez, Salvador

22

Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug  

E-Print Network [OSTI]

Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

Carlyle, Wenda C.

23

Thermo-responsive Layer-by-Layer Assemblies for Nanoparticle-based Drug Delivery  

E-Print Network [OSTI]

release in response to temperature is still challenging. Here, a thermo-responsive drug delivery system of solid dexamethasone nanoparticles (DXM NPs) encapsulated in a model LbL assembly of strong polyelectrolytes poly (diallyldimethylammonium chloride...

Zhou, Jing

2013-11-26T23:59:59.000Z

24

Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device  

E-Print Network [OSTI]

The goal of this thesis was to advance an implantable drug delivery MEMS (MicroElectroMechanical Systems) device developed in our laboratory. This device was designed to locally deliver multiple substances in complex release ...

Li, Yawen, 1972-

2005-01-01T23:59:59.000Z

25

Secondary fuel delivery system  

DOE Patents [OSTI]

A secondary fuel delivery system for delivering a secondary stream of fuel and/or diluent to a secondary combustion zone located in the transition piece of a combustion engine, downstream of the engine primary combustion region is disclosed. The system includes a manifold formed integral to, and surrounding a portion of, the transition piece, a manifold inlet port, and a collection of injection nozzles. A flowsleeve augments fuel/diluent flow velocity and improves the system cooling effectiveness. Passive cooling elements, including effusion cooling holes located within the transition boundary and thermal-stress-dissipating gaps that resist thermal stress accumulation, provide supplemental heat dissipation in key areas. The system delivers a secondary fuel/diluent mixture to a secondary combustion zone located along the length of the transition piece, while reducing the impact of elevated vibration levels found within the transition piece and avoiding the heat dissipation difficulties often associated with traditional vibration reduction methods.

Parker, David M. (Oviedo, FL); Cai, Weidong (Oviedo, FL); Garan, Daniel W. (Orlando, FL); Harris, Arthur J. (Orlando, FL)

2010-02-23T23:59:59.000Z

26

E-Print Network 3.0 - advanced drug delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

nano-biomaterials, pharmaceuticals and drug delivery. They are exploring numerous... the pharmaceutical industry--the PTRC has created a novel inhaled drug delivery method that...

27

Noninvasive quantification of drug delivery from an implantable MEMS device  

E-Print Network [OSTI]

(cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

Johnson, Audrey M., 1976-

2005-01-01T23:59:59.000Z

28

Radiation delivery system and method  

DOE Patents [OSTI]

A radiation delivery system and method are described. The system includes a treatment configuration such as a stent, balloon catheter, wire, ribbon, or the like, a portion of which is covered with a gold layer. Chemisorbed to the gold layer is a radiation-emitting self-assembled monolayer or a radiation-emitting polymer. The radiation delivery system is compatible with medical catheter-based technologies to provide a therapeutic dose of radiation to a lesion following an angioplasty procedure.

Sorensen, Scott A. (Overland Park, KS); Robison, Thomas W. (Los Alamos, NM); Taylor, Craig M. V. (Jemez Springs, NM)

2002-01-01T23:59:59.000Z

29

Novel polyoxazolines polymer drug delivery platform  

E-Print Network [OSTI]

performed with 4 different polymers in multi- drug resistant (MCF7/ADR) human adenocarcinoma cells, non-resistant (MCF7) human adenocarcinoma cells and Madin-Darby canine kidney (MDCK) cells. All polymers were found lines. 2. To investigate the effect of the addition of drugs to the polymers on cell toxicity, micelles

30

Transdermal drug delivery by localized intervention  

E-Print Network [OSTI]

Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

Weaver, James C.

31

Computational model of local intravascular drug delivery  

E-Print Network [OSTI]

Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

Balakrishnan, Brinda

2007-01-01T23:59:59.000Z

32

E-Print Network 3.0 - active drug delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Clinic to introduce students to drug delivery, and in a senior-level elective... of the pharmaceutical industry today, with new drug ... Source: Hesketh, Robert - College of...

33

Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance  

E-Print Network [OSTI]

period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

Clairambault, Jean

34

A Universal Level Converter Towards the Realization of Energy Efficient Implantable Drug Delivery  

E-Print Network [OSTI]

of the system which will then require a heat transfer mech- anism, affecting the portion of the body whereA Universal Level Converter Towards the Realization of Energy Efficient Implantable Drug Delivery and can block an input signal. We have prototyped a ULC using 32nm high-/metal-gate nano-CMOS technology

Mohanty, Saraju P.

35

Synthetic LDL as targeted drug delivery vehicle  

DOE Patents [OSTI]

The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

2012-08-28T23:59:59.000Z

36

The dual-piston jet injector and the viability of drug delivery  

E-Print Network [OSTI]

Drug delivery through jet-injection opens the doors to very rapid drug dispersion by eliminating the need for needle sterilization. With this comes the need for a continuous flow of fluids from a large reservoir, currently ...

Cunningham, Daniel (Daniel P.)

2007-01-01T23:59:59.000Z

37

Fiber coupled optical spark delivery system  

DOE Patents [OSTI]

A spark delivery system for generating a spark using a laser beam is provided, the spark delivery system including a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. In addition, the laser delivery assembly includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. In accordance with embodiments of the present invention, the assembly may be used to create a spark in a combustion engine. In accordance with other embodiments of the present invention, a method of using the spark delivery system is provided. In addition, a method of choosing an appropriate fiber for creating a spark using a laser beam is also presented.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO)

2008-08-12T23:59:59.000Z

38

Towards engineering hormone-binding globulins as drug delivery agents  

E-Print Network [OSTI]

directly for destruction by the body’s immune system. There are currently three antibody-drug conjugates and 11 ‘naked’ monoclonal antibodies approved by the Food and Drug Administration for the treatment of cancers [9, 10]. Another form of immunotherapy... efficacy in many cases [50]. Currently, the most common chemotherapeutic treatment for malignant metastatic prostate cancer is docetaxel, a mitotic poison [51]. In the next part of this proof-of-concept experiment, we sought to show that it is possible...

Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

2014-11-26T23:59:59.000Z

39

Comments of Cisco Systems to Office of Electricity Delivery and...  

Broader source: Energy.gov (indexed) [DOE]

of Cisco Systems to Office of Electricity Delivery and Energy Reliability Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Cisco Systems provides...

40

A safety and tolerability study of differently-charged nanoparticles for local pulmonary drug delivery  

SciTech Connect (OSTI)

Nanoparticle (NP) based drug delivery systems provide promising opportunities in the treatment of lung diseases. Here we examined the safety and tolerability of pulmonary delivered NPs consisting of PEG-PLA as a function of particle surface charge. The rationale for such a comparison should be attributed to the differential pulmonary toxicity of positively and negatively charged PEG-PLA NP. Thus, the local and systemic effects of pulmonary administered NPs were investigated following 5 days of daily endotracheal instillation to BALB/c mice that were euthanized on the eighth or nineteenth day of the experiment. We collected bronchoalveolar lavages and studied hematological as well as histochemistry parameters. Notably, the cationic stearylamine based PEG-PLA NPs elicited increased local and systemic toxic effects both on the eighth and nineteenth day. In contrast, anionic NPs of similar size were much better tolerated with local inflammatory effects observed only on the eighth experimental day after pulmonary instillation. No systemic toxicity effect was observed although a moderate change was noted in the platelet count that was not considered to be of clinical significance. No pathological observations were detected in the internal organs following instillation of anionic NPs. Overall these observations suggest that anionic PEG-PLA NPs are useful pulmonary drug carriers that should be considered as a promising therapeutic drug delivery system.

Harush-Frenkel, Oshrat [Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, 91120 (Israel); Bivas-Benita, Maytal [Beth Israel Deaconess Medical Center, Division of Viral Pathogenesis, Harvard Medical School, Boston, MA 02215 (United States); Nassar, Taher [Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, 91120 (Israel); Springer, Chaim [Institute of Pulmonology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120 (Israel); Sherman, Yoav [Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120 (Israel); Avital, Avraham [Institute of Pulmonology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120 (Israel); Altschuler, Yoram [School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, 91120 (Israel); Borlak, Jurgen [Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Strasse 1, 30625 Hannover (Germany); Benita, Simon, E-mail: benita@cc.huji.ac.i [Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, 91120 (Israel); David R. Bloom Center for Pharmacy at Hebrew University of Jerusalem (Israel)

2010-07-15T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Fiber laser coupled optical spark delivery system  

DOE Patents [OSTI]

A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

2008-03-04T23:59:59.000Z

42

Development of a polylactic acid (PLA) polymer with an acid-sensitive N-ethoxybenzylimidazole (NEBI) crosslinker as a drug delivery system  

E-Print Network [OSTI]

DiamondTM (Barnstead) water purification system before useTM (Barnstead) water purification system before use inTM (Barnstead) water purification system before use in

Hang, Leibniz Fangtinq

2012-01-01T23:59:59.000Z

43

Application of microfluidic emulsion technology to biochemistry, drug delivery and Lab-on-a-Chip programmability  

E-Print Network [OSTI]

This research applies microfluidic emulsion technology to three diverse problems; biochemistry, drug delivery and lab-on-a-chip programmability. These subjects represent distinct research programs, but the underlying physics ...

Urbanski, John Paul

2005-01-01T23:59:59.000Z

44

Renewable energy delivery systems and methods  

DOE Patents [OSTI]

A system, method and/or apparatus for the delivery of energy at a site, at least a portion of the energy being delivered by at least one or more of a plurality of renewable energy technologies, the system and method including calculating the load required by the site for the period; calculating the amount of renewable energy for the period, including obtaining a capacity and a percentage of the period for the renewable energy to be delivered; comparing the total load to the renewable energy available; and, implementing one or both of additional and alternative renewable energy sources for delivery of energy to the site.

Walker, Howard Andrew

2013-12-10T23:59:59.000Z

45

Specific and general binding in arterial drug delivery  

E-Print Network [OSTI]

Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

Levin, Andrew D. (Andrew David), 1976-

2005-01-01T23:59:59.000Z

46

Toward a drug delivery coating for intraocular lenses  

E-Print Network [OSTI]

Layer-by-layer assembly has become a quintessential tool for the creation of versatile, dynamic nanostructured materials able to dictate cellular behavior through exquisite surface functionality and delivery of bioactive ...

Smith, Renée Chivon

2010-01-01T23:59:59.000Z

47

Waste Feed Delivery Transfer System Analysis  

SciTech Connect (OSTI)

This document provides a documented basis for the required design pressure rating and pump pressure capacity of the Hanford Site waste-transfer system in support of the waste feed delivery to the privatization contractor for vitrification. The scope of the analysis includes the 200 East Area double-shell tank waste transfer pipeline system and the associated transfer system pumps for a11 Phase 1B and Phase 2 waste transfers from AN, AP, AW, AY, and A2 Tank Farms.

JULYK, L.J.

2000-05-05T23:59:59.000Z

48

Hg Delivery System Vacuum 25 Oct 2005  

E-Print Network [OSTI]

. S. DEPARTMENT OF ENERGY V. Graves 25 Oct 2005 MERIT Mtg at MIT Oct 17-19 · During Hg delivery system to both design and operations #12;3 OAK RIDGE NATIONAL LABORATORY U. S. DEPARTMENT OF ENERGY V. Graves 25 & return lines - Sump tank & all connecting ports - Hg cylinder & bellows Hg inlet Hg cylinder & Bellows

McDonald, Kirk

49

Development of Novel Polymeric Materials for Gene Therapy and pH-Sensitive Drug Delivery: Modeling, Synthesis, Characterization, and Analysis  

SciTech Connect (OSTI)

The underlying theme of this thesis is the use of polymeric materials in bioapplications. Chapters 2-5 either develop a fundamental understanding of current materials used for bioapplications or establish protocols and procedures used in characterizing and synthesizing novel materials. In chapters 6 and 7 these principles and procedures are applied to the development of materials to be used for gene therapy and drug delivery. Chapter one is an introduction to the ideas that will be necessary to understand the subsequent chapters, as well as a literature review of these topics. Chapter two is a paper that has been published in the ''Journal of Controlled Release'' that examines the mechanism of drug release from a polymer gel, as well as experimental design suggestions for the evaluation of water soluble drug delivery systems. Chapter three is a paper that has been published in the ''Journal of Pharmaceutical Sciences'' that discusses the effect ionic salts have on properties of the polymer systems examined in chapter two. Chapter four is a paper published in the Materials Research Society Fall 2000 Symposium Series dealing with the design and synthesis of a pH-sensitive polymeric drug delivery device. Chapter five is a paper that has been published in the journal ''Biomaterials'' proposing a novel polymer/metal composite for use as a biomaterial in hip arthroplasty surgery. Chapter six is a paper that will appear in an upcoming volume of the Journal ''Biomaterials'' dealing with the synthesis of a novel water soluble cationic polymer with possible applications in non-viral gene therapy. Chapter seven is a paper that has been submitted to ''Macromolecules'' discussing several novel block copolymers based on poly(ethylene glycol) and poly(diethylamino ethyl methacrylate) that possess both pH-sensitive and temperature sensitive properties. Chapter eight contains a summary of the research contained in chapters 2-7 and proposes future research for the gene therapy and drug delivery projects.

Brian Curtis Anderson

2002-08-27T23:59:59.000Z

50

Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection  

SciTech Connect (OSTI)

The central theme of this dissertation is represented by the versatility of mesoporous silica nanomaterials in various applications such as catalysis and bio-applications, with main focus on biological applications of Mesoporous Silica Nanospheres (MSN). The metamorphosis that we impose to these materials from catalysis to sensing and to drug and gene delivery is detailed in this dissertation. First, we developed a synthetic method that can fine tune the amount of chemically accessible organic functional groups on the pores surface of MSN by exploiting electrostatic and size matching between the cationic alkylammonium head group of the cetyltrimethylammonium bromide (CTAB) surfactant and various anionic organoalkoxysilane precursors at the micelle-water interface in a base-catalyzed condensation reaction of silicate. Aiming nature imitation, we demonstrated the catalytic abilities of the MSNs, We utilized an ethylenediamine functional group for chelating Cu{sup 2+} as a catalytic functional group anchored inside the mesopores. Thus, a polyalkynylene-based conducting polymer (molecular wire) was synthesized within the Cu-functionalized MSNs silica catalyst. For sensing applications, we have synthesized a poly(lactic acid) coated mesoporous silica nanosphere (PLA-MSN) material that serves as a fluorescence sensor system for detection of amino-containing neurotransmitters in neutral aqueous buffer. We exploited the mesoporosity of MSNs for encapsulating pharmaceutical drugs. We examined bio-friendly capping molecules such as polyamidoamine dendrimers of generations G2 to G4, to prevent the drug leaching. Next, the drug delivery system employed MSNs loaded with Doxorubicin, an anticancer drug. The results demonstrated that these nano-Trojan horses have ability to deliver Doxorubicin to cancer cells and induce their death. Finally, to demonstrate the potential of MSN as an universal cellular transmembrane nanovehicle, we anchored positively charged dendrimers on the surface of MSN and utilize them to complex cationic DNA. The p-EGFP-CI gene-coated MSN nanocomposite was able to transfect cancer cell lines, such as human HeLa and CHO cancer cell lines. The gene carrier ability of MSNs was further proved by transfecting primary cells and cotransfecting of two different genes in cancer cell lines. In sum, MSN are versatile partners in several types of applications.

Daniela Rodica Radu

2005-12-19T23:59:59.000Z

51

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry...

52

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications National lab researchers, industry partners, and academia...

53

Drug Delivery DOI: 10.1002/anie.201008053  

E-Print Network [OSTI]

into MCF7 breast cancer cells. The As1411­ TMPyP4 complex was resistant to degradation and digestion to MCF7 cells than TMPyP4 itself.[24] Tan and co-workers have developed a DNA self-assembly strategy-quadruplex­aptamer delivery, the photo- sensitizer generated high toxicity to target cells and low toxicity to reference cells

Tan, Weihong

54

CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery with comparisons to in vitro data  

E-Print Network [OSTI]

CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery t Enhanced condensational growth (ECG) is a newly proposed concept for respiratory drug delivery in which and evaluate a CFD model of ECG in a simple tubular geometry with direct comparisons to in vitro results

Frey, Pascal

55

Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang,  

E-Print Network [OSTI]

Chapter 11 Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang, Robert Langer, and Omid C. Farokhzad Abstract The use of biodegradable polymeric nanoparticles. In cancer, targeted polymeric NPs can be used to deliver chemotherapies to tumor cells with greater efficacy

Zhang, Liangfang

56

Microfabrication-Compatible Nanoporous Gold Foams as Biomaterials for Drug Delivery  

E-Print Network [OSTI]

Microfabrication-Compatible Nanoporous Gold Foams as Biomaterials for Drug Delivery Erkin Seker different samples: (i) 12 mm-diameter circular plain glass cover slips; (ii) 5 mm-diameter gold spots patterned on the glass cover slips; (iii) 5 mm-diameter np-Au spots patterned on the glass cover slips

Seker, Erkin

57

Drug Delivery DOI: 10.1002/anie.200802260  

E-Print Network [OSTI]

of a model compound, luciferin, from poly(lactic acid) (PLA) particles (approximately 250­350 nm in size nanoparticle could be engineered to target different cells.[3,6] PLA is an Food and Drug Administration (FDA with supercritical carbon dioxide (sc-CO2). PLA can also serve as a representative material for our process which can

Zare, Richard N.

58

Turbomachine injection nozzle including a coolant delivery system  

DOE Patents [OSTI]

An injection nozzle for a turbomachine includes a main body having a first end portion that extends to a second end portion defining an exterior wall having an outer surface. A plurality of fluid delivery tubes extend through the main body. Each of the plurality of fluid delivery tubes includes a first fluid inlet for receiving a first fluid, a second fluid inlet for receiving a second fluid and an outlet. The injection nozzle further includes a coolant delivery system arranged within the main body. The coolant delivery system guides a coolant along at least one of a portion of the exterior wall and around the plurality of fluid delivery tubes.

Zuo, Baifang (Simpsonville, SC)

2012-02-14T23:59:59.000Z

59

SMART DRUG DELIVERY AND BIONANOTECHNOLOGY Nicholas A Peppas  

E-Print Network [OSTI]

, micropatterned devices, systems for biological recognition, have shown the versatility of these biopolymeric

Peppas, Nicholas A.

60

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Practice DesignConfiguration Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practice DesignConfiguration National lab researchers, industry...

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the...

62

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Visualization and Modeling Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Visualization and Modeling National lab researchers, industry partners, and...

63

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

PracticesStandards Development Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best PracticesStandards Development National lab researchers, industry...

64

Hydrogen Delivery Technologies and Systems- Pipeline Transmission of Hydrogen  

Broader source: Energy.gov [DOE]

Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen. Design and operations standards and materials for hydrogen and natural gas pipelines.

65

Local drug delivery for treatment of brain tumor associated edema  

E-Print Network [OSTI]

Brain tumor associated edema, a common feature of malignant brain neoplasms, is a significant cause of morbidity from brain tumor. Systemic administration of corticosteroids, the standard of care, is highly effective but ...

Ong, Qunya

2014-01-01T23:59:59.000Z

66

Multiple-robot drug delivery strategy through coordinated teams of microswimmers  

SciTech Connect (OSTI)

Untethered robotic microswimmers are very promising to significantly improve various types of minimally invasive surgeries by offering high accuracy at extremely small scales. A prime example is drug delivery, for which a large number of microswimmers is required to deliver sufficient dosages to target sites. For this reason, the controllability of groups of microswimmers is essential. In this paper, we demonstrate simultaneous control of multiple geometrically similar but magnetically different microswimmers using a single global rotating magnetic field. By exploiting the differences in their magnetic properties, we triggered different swimming behaviors from the microswimmers by controlling the frequency and the strength of the global field, for example, one swim and the other does not while exposed to the same control input. Our results show that the balance between the applied magnetic torque and the hydrodynamic torque can be exploited for simultaneous control of two microswimmers to swim in opposite directions, with different velocities, and with similar velocities. This work will serve to establish important concepts for future developments of control systems to manipulate multiple magnetically actuated microswimmers and a step towards using swarms of microswimmers as viable workforces for complex operations.

Kei Cheang, U; Kim, Min Jun, E-mail: mkim@coe.drexel.edu [Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania 19104 (United States); Lee, Kyoungwoo [Department of Computer Science, Yonsei University, Seoul 120-749 (Korea, Republic of); Julius, Anak Agung [Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States)

2014-08-25T23:59:59.000Z

67

Optical diagnostics integrated with laser spark delivery system  

DOE Patents [OSTI]

A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

2008-09-02T23:59:59.000Z

68

Composite gelatin delivery system for bone regeneration  

E-Print Network [OSTI]

In this thesis, the chemical/mechanical properties and biocompatibility of gelatin were investigated to produce a gelatin scaffold for the release of bone morphogenetic proteins (BMPs) from composite particles. This delivery ...

Hager, Elizabeth A. (Elizabeth Ann)

2005-01-01T23:59:59.000Z

69

Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth  

E-Print Network [OSTI]

Assembly of functional nanocomponents offers promising applications in drug delivery to solid tumors and bottom-up synthesis and integration of nanodevices. This thesis presents a novel multistage nanoparticle delivery ...

Wong, Cliff R. (Cliff Richard)

2011-01-01T23:59:59.000Z

70

Delivery system for molten salt oxidation of solid waste  

DOE Patents [OSTI]

The present invention is a delivery system for safety injecting solid waste particles, including mixed wastes, into a molten salt bath for destruction by the process of molten salt oxidation. The delivery system includes a feeder system and an injector that allow the solid waste stream to be accurately metered, evenly dispersed in the oxidant gas, and maintained at a temperature below incineration temperature while entering the molten salt reactor.

Brummond, William A. (Livermore, CA); Squire, Dwight V. (Livermore, CA); Robinson, Jeffrey A. (Manteca, CA); House, Palmer A. (Walnut Creek, CA)

2002-01-01T23:59:59.000Z

71

Providing ordered message delivery in communication network systems  

E-Print Network [OSTI]

PROVIDING ORDERED MESSAGE DELIVERY IN COMMUNICATION NETWORK SYSTEMS A Thesis by JULI0 A. RIVERA-HERNANDEZ Submitted to the Oflice of Graduate Studies of Texas AkM University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE May 1995 Major Subject: Computer Science PROVIDING ORDERED MESSAGE DELIVERY IN COMMUNICATION NETWORK SYSTEMS A Thesis by JULIO A. RIVERA-HERNANDEZ Submitted to Texas ARM University in partial fulfillment of the requirements for the degree...

Rivera-Hernandez, Julio A

1995-01-01T23:59:59.000Z

72

Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen  

Broader source: Energy.gov [DOE]

Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen.Solid and liquid hydrogen carriers for use in hydrogen storage and delivery.

73

Urban Sewage Delivery Heat Transfer System (2): Heat Transfer  

E-Print Network [OSTI]

The thimble delivery heat-transfer (TDHT) system is one of the primary modes to utilize the energy of urban sewage. Using the efficiency-number of transfer units method ( ), the heat-transfer efficiencies of the parallel-flow and reverse-flow TDTH...

Zhang, C.; Wu, R.; Li, X.; Li, G.; Zhuang, Z.; Sun, D.

2006-01-01T23:59:59.000Z

74

Luminosity Stability Issues for the TESLA Beam Delivery System (BDS)  

E-Print Network [OSTI]

Luminosity Stability Issues for the TESLA Beam Delivery System (BDS) Nicholas Walker1 (DESY, Germany) Andrzej Wolski2 (Daresbury Laboratory, UK) TESLA 2000-22 October 17, 2000 1 Introduction Given of ground motion and vibration in linear colliders both for TESLA and NLC/JLC (see for example [1

75

Distributed Power Delivery for Energy Efficient and Low Power Systems  

E-Print Network [OSTI]

Distributed Power Delivery for Energy Efficient and Low Power Systems Selc¸uk K¨ose Department are needed to determine the location of these on-chip power supplies and decoupling capacitors. In this paper, the optimal location of the power supplies and decoupling capacitors is determined for different size

Friedman, Eby G.

76

Mercury Delivery System Tony Gabriel, Phil Spampinato  

E-Print Network [OSTI]

Concept Hydraulic Fluid Cylinder (3000 psi) Hg Cylinder (1000 psi) Hg Discharge Hg Inlet #12;6 OAK RIDGE losses isolated to hydraulic system - Flow losses identical to those in pump system #12;8 OAK RIDGE Motor 20 20 hp * 5% inefficiency 1 19 42 42 1 1 Hyd Pump energy performed on piston = press

McDonald, Kirk

77

Vulnerability Analysis of Energy Delivery Control Systems  

Broader source: Energy.gov (indexed) [DOE]

coding practices can be found in new and old products alike, and the introduction of Web applications into SCADA systems has created more, as well as new, types of...

78

Mercury sorbent delivery system for flue gas  

DOE Patents [OSTI]

The invention presents a device for the removal of elemental mercury from flue gas streams utilizing a layer of activated carbon particles contained within the filter fabric of a filter bag for use in a flue gas scrubbing system.

Klunder; ,Edgar B. (Bethel Park, PA)

2009-02-24T23:59:59.000Z

79

Virtual doctor's office telemedicine delivery system  

E-Print Network [OSTI]

Instrument to acquire and pre-process the patient information, an application to retrieve this information and relay it via the Internet to the Doctor's Office and an application on the doctor's side to obtain the relayed information and present..., and perhaps even diagnosis, treatment and monitoring using broadband networks. (d) Fourth Generation Tele-homecare ? these systems use the Internet to deliver homecare services to the patient. [10] Recent interest in homecare was heralded by the new...

Sainath, Paavana

2002-01-01T23:59:59.000Z

80

Kilogram Scale Synthesis of a Triazine-based Dendrimer and the Development of a General Strategy for the Installation of Pharmacophores to Yield Potential Drug Delivery Agents  

E-Print Network [OSTI]

KILOGRAM SCALE SYNTHESIS OF A TRIAZINE-BASED ENDRIMER AND THE DEVELOPMENT OF A GENERAL STRATEGY FOR THE INSTALATION OF PHARMACOPHORES TO YIELD POTENTIAL DRUG DELIVERY AGENTS A Disertation by VINCENT JOSEPH VENDITO Submited... AND THE DEVELOPMENT OF A GENERAL STRATEGY FOR THE INSTALATION OF PHARMACOPHORES TO YIELD POTENTIAL DRUG DELIVERY AGENTS A Disertation by VINCENT JOSEPH VENDITO Submited to the Ofice of Graduate Studies of Texas A&M University in partial fulfilment...

Venditto, Vincent J.

2011-02-22T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Feasibility Study: Ductless Hydronic Distribution Systems with Fan Coil Delivery  

SciTech Connect (OSTI)

The primary objectives of this study are to estimate potential energy savings relative to conventional ducted air distribution, and to identify equipment requirements, costs, and barriers with a focus on ductless hydronic delivery systems that utilize water-to-air terminal units in each zone. Results indicate that annual heating and cooling energy use can be reduced by up to 27% assuming replacement of the conventional 13 SEER heat pump and coil with a similarly rated air-to-water heat pump.

Springer, D.; Dakin, B.; Backman, C.

2012-07-01T23:59:59.000Z

82

Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System  

E-Print Network [OSTI]

+/- 10 nm were fabricated, characterized and then encapsulated in synthetic / biomacromolecule shell chitosan, dextran-sulfate using a layer by layer (LbL) self-assembly technique. Surface modifications were performed by covalently conjugating with poly...

Yu, Xiao

2012-07-16T23:59:59.000Z

83

Computer controlled feed delivery system for feed trucks  

E-Print Network [OSTI]

/ft), respectively. These values were selected for two reasons: 1) limitations of the model and 2) ease of testing. The scaled-down feed wagon was limited to a bed conveyor speed of 4. 27 m/min (14 fpm). Therefore, the maximum delivery rate/ground speed... the proportional control valve. 22 LIST OF FIGURES (continued) Page Figure 13. Picture of proportional control valve. . 22 Figure 14. Circuit diagram of the hydraulic system on the scaled-down model. . 24 Figure 15. Photograph of the collection box sitting...

Holt, Gregory Alan

2012-06-07T23:59:59.000Z

84

Reliability review of the remote tool delivery system locomotor  

SciTech Connect (OSTI)

The locomotor being built by RedZone Robotics is designed to serve as a remote tool delivery (RID) system for waste retrieval, tank cleaning, viewing, and inspection inside the high-level waste tanks 8D-1 and 8D-2 at West Valley Nuclear Services (WVNS). The RTD systm is to be deployed through a tank riser. The locomotor portion of the RTD system is designed to be inserted into the tank and is to be capable of moving around the tank by supporting itself and moving on the tank internal structural columns. The locomotor will serve as a mounting platform for a dexterous manipulator arm. The complete RTD system consists of the locomotor, dexterous manipulator arm, cameras, lights, cables, hoses, cable/hose management system, power supply, and operator control station.

Chesser, J.B.

1999-04-01T23:59:59.000Z

85

E-Print Network 3.0 - anticancer drug delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Chemistry, University of Utah Collection: Chemistry 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

86

Polarimeters and Energy Spectrometers for the ILC Beam Delivery System  

SciTech Connect (OSTI)

This article gives an overview of current plans and issues for polarimeters and energy spectrometers in the Beam Delivery System of the ILC. It is meant to serve as a useful reference for the Detector Letter of Intent documents currently being prepared. Concepts for high precision polarization and energy measurements exist. These concepts have resulted in detailed system layouts that are included in the RDR description for the Beam Delivery System. The RDR includes both upstream and downstream polarimeters and energy spectrometers for both beams. This provides needed complementarity and redundancy for achieving the precision required, with adequate control and demonstration of systematic errors. The BDS polarimeters and energy spectrometers need to be a joint effort of the ILC BDS team and the Detector collaborations, with collaboration members responsible for the performance and accuracy of the measurements. Details for this collaboration and assigning of responsibilities remain to be worked out. There is also a demonstrated need for Detector physicists to play an active role in the design and evaluation of accelerator components that impact beam polarization and beam energy capabilities, including the polarized source and spin rotator systems. A workshop was held in 2008 on ILC Polarization and Energy measurements, which resulted in a set of recommendations for the ILC design and operation. Additional input and action is needed on these from the Detector collaborations, the Research Director and the GDE. Work is continuing during the ILC engineering design phase to further optimize the polarimeter and energy spectrometer concepts and fully implement them in the ILC. This includes consideration for alternative methods, detailed design and cost estimates, and prototype and test beam activities.

Boogert, S.; /Royal Holloway, U. of London; Hildreth, M.; /Notre Dame U.; Kafer, D.; List, J.; Monig, K.; /DESY; Moffeit, K.C.; /SLAC; Moortgat-Pick, G.; /Durham U., IPPP; Riemann, S.; Schreiber, H.J.; Schuler, P.; /DESY; Torrence, E.; /Oregon U.; Woods, M.; /SLAC

2009-02-24T23:59:59.000Z

87

Rapid cycling medical synchrotron and beam delivery system  

DOE Patents [OSTI]

A medical synchrotron which cycles rapidly in order to accelerate particles for delivery in a beam therapy system. The synchrotron generally includes a radiofrequency (RF) cavity for accelerating the particles as a beam and a plurality of combined function magnets arranged in a ring. Each of the combined function magnets performs two functions. The first function of the combined function magnet is to bend the particle beam along an orbital path around the ring. The second function of the combined function magnet is to focus or defocus the particle beam as it travels around the path. The radiofrequency (RF) cavity is a ferrite loaded cavity adapted for high speed frequency swings for rapid cycling acceleration of the particles.

Peggs, Stephen G. (Port Jefferson, NY); Brennan, J. Michael (East Northport, NY); Tuozzolo, Joseph E. (Sayville, NY); Zaltsman, Alexander (Commack, NY)

2008-10-07T23:59:59.000Z

88

Multiple delivery cesium oven system for negative ion sources  

SciTech Connect (OSTI)

Distribution of cesium in large negative ion beam sources to be operational in ITER, is presently based on the use of three or more cesium ovens, which operate simultaneously and are controlled remotely. However, use of multiple Cs ovens simultaneously is likely to pose difficulties in operation and maintenance of the ovens. An alternate method of Cs delivery, based on a single oven distribution system is proposed as one which could reduce the need of simultaneous operation of many ovens. A proof of principle experiment verifying the concept of a multinozzle distributor based Cs oven has been carried out at Institute for Plasma Research. It is also observed that the Cs flux is not controlled by Cs reservoir temperature after few hours of operation but by the temperature of the distributor which starts behaving as a Cs reservoir.

Bansal, G.; Bhartiya, S.; Pandya, K.; Bandyopadhyay, M.; Singh, M. J.; Soni, J.; Gahlaut, A.; Parmar, K. G.; Chakraborty, A. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat 382428 (India)

2012-02-15T23:59:59.000Z

89

A Scheme for Reliable Delivery of Events in Distributed Middleware Systems Shrideep Pallickara and Geoffrey Fox  

E-Print Network [OSTI]

A Scheme for Reliable Delivery of Events in Distributed Middleware Systems Shrideep Pallickara. These interactions can be encapsulated in events. We describe a scheme for the reliable delivery of events pertaining to transactions, data interchange, system conditions and finally the search, discovery

90

Novel Approaches to Breast Cancer Therapy: Evaluation of Next Generation Dendrimers for Drug Delivery  

E-Print Network [OSTI]

laboratory has shown that treating the cancer cells with a novel dendrimer construct (G2-NH2) alone, without drug or DNA present, can be cytotoxic. The purpose of this study was to test the next generation of dendrimers for the ability to deliver DNA...

Snow, Merideth

2010-07-14T23:59:59.000Z

91

The design and evaluation of a water delivery system for evaporative cooling of a proton exchange membrane fuel cell  

E-Print Network [OSTI]

An investigation was performed to demonstrate system design for the delivery of water required for evaporative cooling of a proton exchange membrane fuel cell (PEMFC). The water delivery system uses spray nozzles capable of injecting water directly...

Al-Asad, Dawood Khaled Abdullah

2009-06-02T23:59:59.000Z

92

Urban Sewage Delivery Heat Transfer System (1): Flow Resistance and Energy Analysis  

E-Print Network [OSTI]

The thimble delivery heat-transfer (TDHT) system is one of the primary modes to utilize the energy of urban sewage. Given the schematic diagram of TDHT system, introducing the definition of equivalent fouling roughness height, and using the Niklaus...

Zhang, C.; Wu, R.; Li, G.; Li, X.; Huang, L.; Sun, D.

2006-01-01T23:59:59.000Z

93

Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)  

ScienceCinema (OSTI)

Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

Forte, Trudy

2011-04-28T23:59:59.000Z

94

Cesium Delivery System for Negative Ion Source at IPR  

SciTech Connect (OSTI)

The technique of surface production of negative ions using cesium, Cs, has been efficiently exploited over the years for producing negative ion beams with increased current densities from negative ion sources used on neutral beam lines. Deposition of Cs on the source walls and the plasma grid lowers the work function and therefore enables a higher yield of H{sup -}, when hydrogen particles (H and/or H{sub x}{sup +}) strike these surfaces.A single driver RF based (100 kW, 1 MHz) negative ion source test bed, ROBIN, is being set up at IPR under a technical collaboration between IPR and IPP, Germany. The optimization of the Cs oven design to be used on this facility as well as multidriver sources is underway. The characterization experiments of such a Cs delivery system with a 1 g Cs inventory have been carried out using surface ionization technique. The experiments have been carried by delivering Cs into a vacuum chamber without plasma. The linear motion of the surface ionization detector, SID, attached with a linear motion feedthrough allows measuring the angular distribution of the Cs coming out of the oven. Based on the experimental results, a Cs oven for ROBIN has been proposed. The Cs oven design and experimental results of the prototype Cs oven are reported and discussed in the paper.

Bansal, G.; Pandya, K.; Soni, J.; Gahlaut, A.; Parmar, K. G. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat, 382 428 (India); Bandyopadhyay, M.; Chakraborty, A.; Singh, M. J. [ITER- India, Institute for Plasma Research, A-29, Sector 25, GIDC, Gandhinagar, Gujarat (India)

2011-09-26T23:59:59.000Z

95

Development and Optimization of Polymeric Carriers for Lymphatic Imaging and Drug Delivery  

E-Print Network [OSTI]

Many cancers, including melanoma and breast cancer, metastasize via the lymphatic system, a mono-directional network of vessels and nodes that parallels the circulatory system. Accurate determination of the lymph nodes ...

Bagby, Taryn Rochelle

2011-12-31T23:59:59.000Z

96

Chapter III. Processes F. Land-Based N Sources and Their Delivery to Coastal Systems  

E-Print Network [OSTI]

to terrestrial systems of newly fixed N2 (the conversion of relatively inert N2 gas to more bioavailable N forms can be important pathways for delivery of land-based N sources. This chapter focuses on export of N

Seitzinger, Sybil

97

Genome-Free Viral Capsids for Targeted Drug Delivery to Breast Cancer  

E-Print Network [OSTI]

Water (ddH 2 O) used in biological procedures or as a reaction solvent was deionized using a NANOpure TM purification system (Water (ddH 2 O) used in biologi- cal procedures or as a reaction solvent was deionized using a NANOpure TM purification system (

Wu, Wesley

2012-01-01T23:59:59.000Z

98

Evaluation & design of a novel drug delivery device for treating tumor-related cerebral edema  

E-Print Network [OSTI]

Tumor-related cerebral edema is a debilitating medical condition that afflicts tens of thousands of newly diagnosed brain cancer patients in the U.S. each year, where the standard care of treatment indicates the systemic ...

Shair, Kamal A. (Kamal Abdo)

2010-01-01T23:59:59.000Z

99

Lymphocyte-mediated drug nanoparticle delivery to disseminated lymphoma tumors in vivo  

E-Print Network [OSTI]

The dissemination of lymphoma into anatomical compartments that are poorly accessible from circulation, such as lymph nodes, necessitates high doses of systemic chemotherapy. However, the potencies of many chemotherapeutic ...

Huang, Bonnie

2013-01-01T23:59:59.000Z

100

2 Delivery of Learning Design: the Explor@ System's Case Delivery of Learning Design: the Explor@  

E-Print Network [OSTI]

: the Explor@ System's Case Primary author(s): Gilbert Paquette and Olga Marino, Other author(s): Ileana de la, for design- ing and developing learning systems as well as two software tools, MOT and ADISA, developed

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Multistage nanoparticle delivery system for deep penetration into tumor  

E-Print Network [OSTI]

Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...

Wong, Cliff

102

Control system and method for a power delivery system having a continuously variable ratio transmission  

DOE Patents [OSTI]

A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine.

Frank, Andrew A. (1034 Hillside Ave., Madison, WI 53705)

1984-01-01T23:59:59.000Z

103

Control system and method for a power delivery system having a continuously variable ratio transmission  

DOE Patents [OSTI]

A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine. 4 figs.

Frank, A.A.

1984-07-10T23:59:59.000Z

104

Fault-Tolerant Reliable Delivery of Messages in Distributed Publish/Subscribe Systems Shrideep Pallickara, Hasan Bulut and Geoffrey Fox  

E-Print Network [OSTI]

1/10 Fault-Tolerant Reliable Delivery of Messages in Distributed Publish/Subscribe Systems Shrideep in distributed systems. In this paper we present our strategy to enable reliable delivery of messages. Messaging is a critical component in distributed systems. Here, the messaging infrastructure can be based

105

Electrical-Thermal Co-analysis for Power Delivery Networks in 3D System Integration  

E-Print Network [OSTI]

Electrical-Thermal Co-analysis for Power Delivery Networks in 3D System Integration Jianyong Xie1 Rubin3 1 School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332 2 IBM Package Design, Development, and Electrical Services Group, Poughkeepsie, N.Y. 12601 3 IBM T

Swaminathan, Madhavan

106

Percutaneous Valve Replacement: Significance of Different Delivery Systems In Vitro and In Vivo  

SciTech Connect (OSTI)

Background and purpose. Percutaneous heart valve replacement is an exciting growing field in cardiovascular medicine yet still with some major problems. Only sophisticated improvement of the instruments could make it a real alternative to conventional surgery. Therefore, the aim of this study was to evaluate different delivery devices for percutaneous heart valve replacement in vitro and in vivo. Methods. A catheter prototype designed by our group, and two commercially available devices for the delivery of esophageal stents and aortic endoprostheses, were tested. After in vitro experiments, an ovine animal model of transfemoral pulmonary valve implantation was established using biological valved self-expanding stents. Only the delivery device for aortic endografts (Medtronic, Talent, Santa Rosa, CA, USA) allowed fast in vitro procedures without material fatigue. This device was chosen for the in vivo tests. Results. Technical success was achieved in 9 of 10 animals (90%). One animal died after perforation of the ventricular wall. Orthotopic pulmonary placement was performed in 6 animals and intentional supravalvular valved stent placement in 3 animals. Conclusions. An adequate in vitro model for this evolving field of interventional heart valve replacement is presented. Furthermore, the present study pinpoints the key characteristics that are mandatory for a delivery system in percutaneous pulmonary valve implantation. With regard to the delivery device's ductility observed during this 'venous' study, an approach to transfemoral aortic valve implantation seems feasible.

Attmann, Tim; Lutter, Georg, E-mail: lutter@kielheart.uni-kiel.de; Quaden, Rene [Christian Albrechts University of Kiel, Department of Cardiovascular Surgery, School of Medicine (Germany); Jahnke, Thomas [Christian Albrechts University of Kiel, Department of Radiology, School of Medicine (Germany); Rumberg, Kristin; Cremer, Jochen [Christian Albrechts University of Kiel, Department of Cardiovascular Surgery, School of Medicine (Germany); Muller-Hulsbeck, Stefan [Christian Albrechts University of Kiel, Department of Radiology, School of Medicine (Germany)

2006-06-15T23:59:59.000Z

107

Hedva_roffe@edwards.com# to be send to4120CVs remarking position R&D Delivery systems Engineer Position #1204  

E-Print Network [OSTI]

Position #1204 R&D Delivery systems EngineerPosition' title: Develop and design Delivery systems systems design in the medical devices industry Proven Solid-works experience Lab testing mustHedva_roffe@edwards.com# to be send to4120CVs remarking position R&D Delivery systems Engineer

Rimon, Elon

108

Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery  

E-Print Network [OSTI]

Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what ...

Vukmirovic, Neda

2007-01-01T23:59:59.000Z

109

A Cassette Based System for Hydrogen Storage and Delivery  

SciTech Connect (OSTI)

A hydrogen storage system is described and evaluated. This is based upon a cassette, that is a container for managing hydrogen storage materials. The container is designed to be safe, modular, adaptable to different chemistries, inexpensive, and transportable. A second module receives the cassette and provides the necessary infrastructure to deliver hydrogen from the cassette according to enduser requirements. The modular concept has a number of advantages over approaches that are all in one stand alone systems. The advantages of a cassette based system are discussed, along with results from model and laboratory testing.

Britton Wayne E.

2006-11-29T23:59:59.000Z

110

Systems and methods for bi-directional energy delivery with galvanic isolation  

DOE Patents [OSTI]

Systems and methods are provided for bi-directional energy delivery. A charging system comprises a first bi-directional conversion module, a second bi-directional conversion module, and an isolation module coupled between the first bi-directional conversion module and the second bi-directional conversion module. The isolation module provides galvanic isolation between the first bi-directional conversion module and the second bi-directional conversion module.

Kajouke, Lateef A.

2013-06-18T23:59:59.000Z

111

System and method for delivery of neutron beams for medical therapy  

DOE Patents [OSTI]

A neutron delivery system that provides improved capability for tumor control during medical therapy is disclosed. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention. 5 figs.

Nigg, D.W.; Wemple, C.A.

1999-07-06T23:59:59.000Z

112

System and method for delivery of neutron beams for medical therapy  

DOE Patents [OSTI]

A neutron delivery system that provides improved capability for tumor control during medical therapy. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention.

Nigg, David W. (Idaho Falls, ID); Wemple, Charles A. (Idaho Falls, ID)

1999-01-01T23:59:59.000Z

113

antigen delivery system: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to transition to an efficient and automated cookie packaging line at the Gamesa-Quaker plant in Monterrey, Mexico, the goal of this project was to design an improved system to...

114

Electrical swing adsorption gas storage and delivery system  

DOE Patents [OSTI]

Systems and methods for electrical swing natural gas adsorption are described. An apparatus includes a pressure vessel; an electrically conductive gas adsorptive material located within the pressure vessel; and an electric power supply electrically connected to said adsorptive material. The adsorptive material can be a carbon fiber composite molecular sieve (CFCMS). The systems and methods provide advantages in that both a high energy density and a high ratio of delivered to stored gas are provided. 5 figs.

Judkins, R.R.; Burchell, T.D.

1999-06-15T23:59:59.000Z

115

Electrical swing adsorption gas storage and delivery system  

DOE Patents [OSTI]

Systems and methods for electrical swing natural gas adsorption are described. An apparatus includes a pressure vessel; an electrically conductive gas adsorptive material located within the pressure vessel; and an electric power supply electrically connected to said adsorptive material. The adsorptive material can be a carbon fiber composite molecular sieve (CFCMS). The systems and methods provide advantages in that both a high energy density and a high ratio of delivered to stored gas are provided.

Judkins, Roddie R. (Knoxville, TN); Burchell, Timothy D. (Oak Ridge, TN)

1999-01-01T23:59:59.000Z

116

Methodology for the production and delivery of generative music for the personal listener : systems for realtime generative music production   

E-Print Network [OSTI]

This thesis will describe a system for the production of generative music through specific methodology, and provide an approach for the delivery of this material. The system and body of work will be targeted specifically ...

Murphy, Michael J.

2013-11-27T23:59:59.000Z

117

Alveolar targeting of aerosol pentamidine. Toward a rational delivery system  

SciTech Connect (OSTI)

Nebulizer systems that deposit a high proportion of aerosolized pentamidine on large airways are likely to be associated with marked adverse side effects, which may lead to premature cessation of treatment. We have measured alveolar deposition and large airway-related side effects (e.g., cough, breathlessness, and effect on pulmonary function) after aerosolization of 150 mg pentamidine isethionate labeled with {sup 99m}Tc-Sn-colloid. Nine patients with AIDS were studied using three nebulizer systems producing different droplet size profiles: the Acorn System 22, Respirgard II, and Respirgard II with the inspiratory baffle removed. Alveolar deposition was greatest and side effects least with the nebulizer producing the smallest droplet size profile (Respirgard II), whereas large airway-related side effects were prominent and alveolar deposition lowest with the nebulizer producing the largest droplet size (Acorn System 22). Values for alveolar deposition and adverse airway effects were intermediate using the Respirgard with inspiratory baffle removed, thus indicating the importance of the baffle valve in determining droplet size. Addition of a similar baffle valve to the Acorn System 22 produced a marked improvement in droplet size profile. Selection of a nebulizer that produces an optimal droplet size range offers the advantage of enhancing alveolar targeting of aerosolized pentamidine while reducing large airway-related side effects.

Simonds, A.K.; Newman, S.P.; Johnson, M.A.; Talaee, N.; Lee, C.A.; Clarke, S.W. (Royal Free Hospital, London (England))

1990-04-01T23:59:59.000Z

118

Alternate Air Delivery Systems for Hot and Humid Climates  

E-Print Network [OSTI]

Carter & Burgess first began using triple deck multi-zone units, in place of traditional VAV systems, on the Texas State Capitol restoration. Since the completion of that project design in early 1991, our firm has now used triple deck multi...

Wallace, M.

1996-01-01T23:59:59.000Z

119

aerosol delivery systems: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

at The Second Science Team Meeting of the Atmospheric System Research (ASR) Program, San Antonio First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22...

120

Cybersecurity for Energy Delivery Systems 2010 Peer Review | Department of  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power Systems EngineeringDepartmentSmart GridThird QuarterintoCurrent

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

antirheumatic drugs dmards: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

122

antineoplastic drugs: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

123

antineoplastic drugs chimio-radiotherapie: Topics by E-print...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

124

Health system accountability and primary health care delivery in rural Kenya. An analysis of the structures, PROCESS, and outcomes.  

E-Print Network [OSTI]

Globally, health systems accountability and engagement are increasingly claimed to be vital means to improve services by providing mechanisms for potential beneficiaries to contribute to the design, implementation, and evaluation of service delivery...

Atela, Martin Hill

2013-11-12T23:59:59.000Z

125

Cost Comparison of Public Elementary School Construction Costs Based on Project Delivery System in the State of Texas  

E-Print Network [OSTI]

and cost controls. Reinisch and Caguioa (2010) noted that there are several methods for choosing what the construction authority considers the most appropriate project delivery system. Nichols and Feigenbaum (Feigenbaum, 2011; Nichols, 2011) observed... Members, Leslie H. Feigenbaum Head of Department, Joseph P. Horlen December 2011 Major Subject: Construction Management iii ABSTRACT Cost Comparison of Public Elementary School Construction Costs Based on Project Delivery System in the State...

Reinisch, Ashley

2012-02-14T23:59:59.000Z

126

Source and Extraction for Simultaneous Four-hall Beam Delivery System at CEBAF  

SciTech Connect (OSTI)

A new design for simultaneous delivery of the electron beam to all four 12 GeV CEBAF experimental halls* requires a new 750 MHz RF separator system in the 5th pass extraction region, a 250 MHz repetition rate for its beams, and addition of a fourth laser at the photo-cathode gun. The proposed system works in tandem with the existing 500 MHz RF separators and beam repetition rate on the lower passes. The new 5th pass RF separators will have the same basic design but modified to run at 750 MHz. The change to the beam repetition rate will be at the photo-cathode gun through an innovative upgrade of the seed laser driver system using electro-optic modulators. The new laser system also allows addition of the fourth laser. The new RF separators, the new laser system and other hardware changes required to implement the Four-Hall operation delivery system will be discussed in this paper.

Kazimi, Reza; Wang, Haipeng; Spata, Mike F.; Hansknecht, John C.

2013-06-01T23:59:59.000Z

127

Nonlinear Decelerator for Payloads in Aerial Delivery Systems. I: Design and Testing  

E-Print Network [OSTI]

We study the dynamics and the optimization of the shock deceleration supported by a payload when its airborne carrier impacts the ground. We build a nonlinear elastic model for a container prototype and an elastic suspension system for the payload. We model the dynamics of this system and extract information on maximum deceleration, energy transfer between the container and payload, and energy resonant damping. We designed the system and perform lab experiments for various terminal velocities and types of grounds (cement, grass, sand water, etc.). The results are compared with the theoretical model and results are commented, including predictions for deceleration at different types of ground impact. The results can be used for aerial delivery systems, splash-down of capsules, recoveries, weather balloons, coastal surveying systems, or the new introduced goal-line technology in sport competitions.

T. Lyons; M. Ginther; P. Mascarenas; E. Rickard; J. Robinson; J. Braeger; H. Liu; A. Ludu

2014-08-19T23:59:59.000Z

128

Soil chemical sensor and precision agricultural chemical delivery system and method  

DOE Patents [OSTI]

A real time soil chemical sensor and precision agricultural chemical delivery system includes a plurality of ground-engaging tools in association with individual soil sensors which measure soil chemical levels. The system includes the addition of a solvent which rapidly saturates the soil/tool interface to form a conductive solution of chemicals leached from the soil. A multivalent electrode, positioned within a multivalent frame of the ground-engaging tool, applies a voltage or impresses a current between the electrode and the tool frame. A real-time soil chemical sensor and controller senses the electrochemical reaction resulting from the application of the voltage or current to the leachate, measures it by resistivity methods, and compares it against pre-set resistivity levels for substances leached by the solvent. Still greater precision is obtained by calibrating for the secondary current impressed through solvent-less soil. The appropriate concentration is then found and the servo-controlled delivery system applies the appropriate amount of fertilizer or agricultural chemicals substantially in the location from which the soil measurement was taken.

Colburn, Jr., John W. (Houston, TX)

1991-01-01T23:59:59.000Z

129

Soil chemical sensor and precision agricultural chemical delivery system and method  

DOE Patents [OSTI]

A real time soil chemical sensor and precision agricultural chemical delivery system includes a plurality of ground-engaging tools in association with individual soil sensors which measure soil chemical levels. The system includes the addition of a solvent which rapidly saturates the soil/tool interface to form a conductive solution of chemicals leached from the soil. A multivalent electrode, positioned within a multivalent frame of the ground-engaging tool, applies a voltage or impresses a current between the electrode and the tool frame. A real-time soil chemical sensor and controller senses the electrochemical reaction resulting from the application of the voltage or current to the leachate, measures it by resistivity methods, and compares it against pre-set resistivity levels for substances leached by the solvent. Still greater precision is obtained by calibrating for the secondary current impressed through solvent-less soil. The appropriate concentration is then found and the servo-controlled delivery system applies the appropriate amount of fertilizer or agricultural chemicals substantially in the location from which the soil measurement was taken. 5 figures.

Colburn, J.W. Jr.

1991-07-23T23:59:59.000Z

130

Fault Tolerant Reliable Delivery of Events in Distributed Middleware Systems Shrideep Pallickara, Geoffrey Fox and Hasan Bulut  

E-Print Network [OSTI]

Fault Tolerant Reliable Delivery of Events in Distributed Middleware Systems Shrideep Pallickara interchangeably) is an important problem that needs to be addressed in distributed systems. Increasingly, interactions between entities within a distributed system are encapsulated in events. In this paper we present

131

Waste Feed Delivery System Phase 1 Preliminary RAM Analysis [SEC 1 and 2  

SciTech Connect (OSTI)

This report presents the updated results of the preliminary reliability, availability, and maintainability (RAM) analysis of selected waste feed delivery (WFD) operations to be performed by the Tank Farm Contractor (TFC) during Phase I activities in support of the Waste Treatment and Immobilization Plant (WTP). For planning purposes, waste feed tanks are being divided into five classes in accordance with the type of waste in each tank and the activities required to retrieve, qualify, and transfer waste feed. This report reflects the baseline design and operating concept, as of the beginning of Fiscal Year 2000, for the delivery of feed from three of these classes, represented by source tanks 241-AN-102, 241-AZ-101 and 241-AN-105. The preliminary RAM analysis quantifies the potential schedule delay associated with operations and maintenance (OBM) field activities needed to accomplish these operations. The RAM analysis is preliminary because the system design, process definition, and activity planning are in a state of evolution. The results are being used to support the continuing development of an O&M Concept tailored to the unique requirements of the WFD Program, which is being documented in various volumes of the Waste Feed Delivery Technical Basis (Carlson. 1999, Rasmussen 1999, and Orme 2000). The waste feed provided to the WTP must: (1) meet limits for chemical and radioactive constituents based on pre-established compositional envelopes (i.e., feed quality); (2) be in acceptable quantities within a prescribed sequence to meet feed quantities; and (3) meet schedule requirements (i.e., feed timing). In the absence of new criteria related to acceptable schedule performance due to the termination of the TWRS Privatization Contract, the original criteria from the Tank Waste Remediation System (77443s) Privatization Contract (DOE 1998) will continue to be used for this analysis.

DYKES, A.A.

2000-10-11T23:59:59.000Z

132

E-Print Network 3.0 - anesthetic systemic toxicity Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

British Women Mystery Writers Summary: A Fluorescent Urine Probe for Prostate Cancer Aerogels as Drug Delivery Systems An Investigation of Heavy Metal... Toxic Metal...

133

Tools and Methods for Hardening Communication Security of Energy Delivery Systems  

SciTech Connect (OSTI)

This document summarizes the research and development work the TT Government Solutions (TTGS), d.b.a. Applied Communication Sciences (ACS), team performed for the Department of Energy Cybersecurity for Energy Delivery Systems (CEDS) program. It addresses the challenges in protecting critical grid control and data communication, including the identification of vulnerabilities and deficiencies of communication protocols commonly used in energy delivery systems (e.g., ICCP, DNP3, C37.118, C12.22), as well as the development of effective means to detect and prevent the exploitation of such vulnerabilities and deficiencies. The team consists of • TT Government Solutions (TTGS), a leading provider of communications solutions that has extensive experience in commercializing communications solutions. TTGS also has deep cyber security research and development expertise supporting a variety of customers. • University of Illinois at Urbana-Champaign (UIUC), a leader in the cyber security research for the power grid. UIUC brings unique experience in designing secure communication protocols to this project. • Electric Power Research Institute (EPRI), an independent nonprofit that conducts research and development relating to the generation, delivery and use of electricity for the benefit of the public. EPRI brings to this effort its extensive technical expertise and its utility connections, with members representing more than 90 percent of the electricity generated and delivered in the United States. • DTE Energy, the 10th largest electric utility in the US, which helps ensure that this project focuses on the needs of utilities and is rightly positioned to address the needs of the market place. We designed, developed, and demonstrated a modular and extensible ADEC-G (Agent-based, Distributed, Extensible Cybersecurity for the Grid) system for monitoring/detecting abnormal energy delivery systems (EDS) protocol usage and ensuring security coverage. Our approach consists of i. An online system with stateful model based checkers (SMBCs) that helps utilities monitor EDS protocol communication contexts and flag abnormal session behaviors; ii. An offline framework that security tool developers, operators, and auditors can use to verify security properties (leverages formal methods). The modular design of the ADEC-G online system enables its easy extension to cover added protocol features, to introduce new monitoring capabilities, and to apply to additional communication protocols. Its monitoring capabilities and user interface features also facilitate visibilities into ongoing communication patterns and quick grasps of suspicious communication activities. The offline framework provides a platform not only for rigorous validation of security coverage, but also for systematic refinement of checker design leveraging the counter traces generated by the model checking tool. The ADEC-G online monitoring/detection system and the offline validation framework are both operational and have been demonstrated in various settings. The ADEC-G online system has also been integrated into TTGS SecureSmart Managed Security Services offering and been employed to perform security assessment in a section of a utility’s operational network as well as in other Smart Grid security pilot project offerings. TTGS is also in discussions with several system integrators for incorporating the integrated SecureSmart Managed Security Services offering as the cyber security solution for the nce of Operations Technology (OT) and Information Technology (IT).

Gadgil, Shrirang; Lin, Yow-Jian; Ghosh, Abhrajit; Samtani, Sunil; Kang, Jaewon; Siegell, Bruce; Kaul, Vikram; Unger, John; De Bruet, Andre; Martinez, Catherine; Vermeulen, Gerald; Rasche, Galen; Sternfeld, Scott; Berthier, Robin; Bobba, Rakesh; Campbell, Roy; Sanders, Williams; Lin, Yow-Jian

2014-06-30T23:59:59.000Z

134

Vaccine delivery with microneedle skin patches in nonhuman primates  

E-Print Network [OSTI]

Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. However, to achieve efficient delivery of vaccines and other macromolecular therapeutics ...

Li, Adrienne V

135

A Lorentz-force actuated controllable needle-free drug delivery system  

E-Print Network [OSTI]

The advantages of delivering injections via needle-free methods are numerous. However, conventional methods for needle-free injection lack sufficient control over depth of penetration and shape of injection. Thus, a ...

Hemond, Brian D. (Brian David Thomson)

2004-01-01T23:59:59.000Z

136

Nanostructured gene and drug delivery systems based on molecular self-assembly  

E-Print Network [OSTI]

Molecular self-assembly describes the assembly of molecular components into complex, supramolecular structures governed by weak, non-covalent interactions. In recent years, molecular self-assembly has been used extensively ...

Wood, Kris Cameron

2007-01-01T23:59:59.000Z

137

Bioactive and bioresponsive nanoparticle surface modifications for vaccine and systemic drug delivery  

E-Print Network [OSTI]

stealth’ coatings have been developed to function in similar ways to PEG by preventing recognition of the foreign material

Clawson, Corbin Zean

2011-01-01T23:59:59.000Z

138

anti-parkinsonian drug selegiline: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

139

Oral Drug Absorption  

E-Print Network [OSTI]

properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

Yamashita, Shinji

2006-10-26T23:59:59.000Z

140

Design and optimization of a multi-particle accelerator beam transport and delivery system for material irradiation in nuclear and fusion science  

E-Print Network [OSTI]

A beam delivery and transport system were designed for the use in MIT Materials Test Facility (M2TF). The purpose of this beam delivery system was to design a 36 MeV Proton Cyclotron for DPA accumulation and a 100 MeV ...

Sordelet, Tyler Christopher

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Waste Feed Delivery System Phase 1 Preliminary Reliability and Availability and Maintainability Analysis [SEC 1 and 2  

SciTech Connect (OSTI)

The document presents updated results of the preliminary reliability, availability, maintainability analysis performed for delivery of waste feed from tanks 241-AZ-101 and 241-AN-105 to British Nuclear Fuels Limited, inc. under the Tank Waste Remediation System Privatization Contract. The operational schedule delay risk is estimated and contributing factors are discussed.

CARLSON, A.B.

1999-11-11T23:59:59.000Z

142

NGNP Data Management and Analysis System Analysis and Web Delivery Capabilities  

SciTech Connect (OSTI)

Projects for the Very High Temperature Reactor (VHTR) Technology Development Office provide data in support of Nuclear Regulatory Commission licensing of the very high temperature reactor. Fuel and materials to be used in the reactor are tested and characterized to quantify performance in high-temperature and high-fluence environments. The NGNP Data Management and Analysis System (NDMAS) at the Idaho National Laboratory has been established to ensure that VHTR data are (1) qualified for use, (2) stored in a readily accessible electronic form, and (3) analyzed to extract useful results. This document focuses on the third NDMAS objective. It describes capabilities for displaying the data in meaningful ways and for data analysis to identify useful relationships among the measured quantities. The capabilities are described from the perspective of NDMAS users, starting with those who just view experimental data and analytical results on the INL NDMAS web portal. Web display and delivery capabilities are described in detail. Also the current web pages that show Advanced Gas Reactor, Advanced Graphite Capsule, and High Temperature Materials test results are itemized. Capabilities available to NDMAS developers are more extensive, and are described using a second series of examples. Much of the data analysis efforts focus on understanding how thermocouple measurements relate to simulated temperatures and other experimental parameters. Statistical control charts and correlation monitoring provide an ongoing assessment of instrument accuracy. Data analysis capabilities are virtually unlimited for those who use the NDMAS web data download capabilities and the analysis software of their choice. Overall, the NDMAS provides convenient data analysis and web delivery capabilities for studying a very large and rapidly increasing database of well-documented, pedigreed data.

Cynthia D. Gentillon

2011-09-01T23:59:59.000Z

143

Investigation of Degradation Properties of Poly(lactide-co-glycolide) Matrix for Anticancer Agent Delivery  

SciTech Connect (OSTI)

Poly(lactide-co-glycolide)(PLA{sub 50}GA{sub 50}) is a biodegradable and biocompatible polymer. It offers tremendous potential as a basis for drug delivery, either as drug delivery system alone or in conjugate with a medical device. The PLA{sub 50}GA{sub 50} is the material of choice for relatively shorter-duration applications, while the homopolymer PLA (poly-L-lactide) and PGA (polyglycolide) are preferred for longer term delivery of drugs. This paper discusses the degradation properties of poly(lactide-co-glycolide)(PLA{sub 50}GA{sub 50}) at inherent viscosity of 0.89 dL/g as preliminary studies for anticancer agent delivery.

Ghani, S. M.; Mohamed, M. S. W.; Yahya, A. F.; Noorsal, K. [Advanced Materials Research Centre (AMREC), SIRIM Berhad, Lot 34, Jalan Hi-Tech 2/3, Kulim Hi-Tech Park, 09000 Kulim Kedah (Malaysia)

2010-03-11T23:59:59.000Z

144

A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA  

E-Print Network [OSTI]

Protein-based methods of targeted short-interfering RNA (siRNA) delivery have the potential to solve some of the problems faced by nanoparticle-based methods, such as poor pharmacokinetics and biodistribution, low tumor ...

Liu, David V.

145

Instrument Failures for the da Vinci Surgical System: a Food and Drug Administration MAUDE Database Study  

E-Print Network [OSTI]

reports. The majority of failures (285) were of the instrument's wrist or tool tip. Cautery problemsInstrument Failures for the da Vinci Surgical System: a Food and Drug Administration MAUDE Database Background Our goal was to analyze reported instances of the da Vinci robotic surgical system instrument

146

Floating hot-melt extruded tablets for gastroretentive controlled drug release system  

E-Print Network [OSTI]

a gastric floating dosage form using the puff ability at the die of a twin-screw extruder. Wei et al. [21Floating hot-melt extruded tablets for gastroretentive controlled drug release system Mamoru Fukuda bicarbonate on the physicochemical properties of controlled release hot- melt extruded (HME) tablets

Peppas, Nicholas A.

147

Lubricating system for thermal medium delivery parts in a gas turbine  

DOE Patents [OSTI]

Cooling steam delivery tubes extend axially along the outer rim of a gas turbine rotor for supplying cooling steam to and returning spent cooling steam from the turbine buckets. Because of the high friction forces at the interface of the tubes and supporting elements due to rotor rotation, a low coefficient of friction coating is provided at the interface of the tubes and support elements. On each surface, a first coating of a cobalt-based alloy is sprayed onto the surface at high temperature. A portion of the first coating is machined off to provide a smooth, hard surface. A second ceramic-based solid film lubricant is sprayed onto the first coating. By reducing the resistance to axial displacement of the tubes relative to the supporting elements due to thermal expansion, the service life of the tubes is substantially extended.

Mashey, Thomas Charles (Coxsackie, NY)

2002-01-01T23:59:59.000Z

148

System Description for the K-25/K-27 D&D Project Polyurethane Foam Delivery System, East Tennessee Technology Park, Oak Ridge, Tennessee  

SciTech Connect (OSTI)

The Foam Delivery System used in the decontamination and decommissioning (D&D) project for the K-25/K-27 Buildings at the East Tennessee Technology Park (ETTP) is comprised of a trailer-mounted Gusmer{reg_sign} H20/35 Pro-TEC Proportioning Unit and the associated equipment to convey electrical power, air, and foam component material to the unit. This high-pressure, plural-component polyurethane foam pouring system will be used to fill process gas and non-process equipment/piping (PGE/P) within the K-25/K-27 Buildings with polyurethane foam to immobilize contaminants prior to removal. The system creates foam by mixing isocyanate and polyol resin (Resin) component materials. Currently, the project plans to utilize up to six foaming units simultaneously during peak foaming activities. Also included in this system description are the foam component material storage containers that will be used for storage of the component material drums in a staging area outside of the K-25/K-27 Buildings. The Foam Delivery System and foam component material storage enclosures (i.e., Foaming Component Protective Enclosures) used to store polymeric methylene diphenyl diisocyanate (PMDI) component material are identified as Safety Significant (SS) Structures, Systems and Components (SSC) in the Documented Safety Analysis (DSA) for the project, Documented Safety Analysis for the K-25 and K-27 Facilities at the East Tennessee Technology Park, Oak Ridge, Tennessee, DSA-ET-K-25/K-27-0001.

Boris, G.

2008-02-21T23:59:59.000Z

149

Design of a robust, intuitive piston interface for a needle free injection system  

E-Print Network [OSTI]

The MIT BioInstrumentation Lab's linear Lorentz force actuator based needle free injection system has been shown to have numerous benefits over needle-based and other needle-free drug delivery systems in a research ...

Nawrot, Michael Thomas

2014-01-01T23:59:59.000Z

150

Safe and compact ammonia storage/delivery systems for SCR-DeNOX...  

Office of Environmental Management (EM)

Safe and compact ammonia storagedelivery systems for SCR-DeNOX in automotive units Safe and compact ammonia storagedelivery systems for SCR-DeNOX in automotive units Presentation...

151

Gaseous Hydrogen Delivery Breakout - Strategic Directions for...  

Broader source: Energy.gov (indexed) [DOE]

System Issues: need to assess delivery options in context of total system Materials: corrosion, H2 permeability Construction: welding, joining Maintenance and Operation: leak...

152

A survey of commercially available manipulators, end-effectors, and delivery systems for reactor decommissioning activities  

SciTech Connect (OSTI)

Numerous nuclear facilities owned by the U.S. Department of Energy (DOE) are under consideration for decommissioning. Currently, there are no standardized, automated, remote systems designed to dismantle and thereby reduce the size of activated reactor components and vessels so that they can be packaged and shipped to disposal sites. Existing dismantling systems usually consist of customized, facility-specific tooling that has been developed to dismantle a specific reactor system. Such systems have a number of drawbacks. Generally, current systems cannot be disassembled, moved, and reused. Developing and deploying the tooling for current systems is expensive and time-consuming. In addition, the amount of manual work is significant because long-handled tools must be used; as a result, personnel are exposed to excessive radiation. A standardized, automated, remote system is therefore needed to deliver the tooling necessary to dismantle nuclear facilities at different locations. Because this system would be reusable, it would produce less waste. The system would also save money because of its universal design, and it would be more reliable than current systems.

Henley, D.R. [Argonne National Lab., IL (United States); Litka, T.J. [Advanced Consulting Group, Chicago, IL (United States)

1996-05-01T23:59:59.000Z

153

automated insulin-delivery systems: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Ioannou A, utomatic is todesign and test avehicle control system in order toachieve full vehicle automation in the longitudinal vehicle following isan important feature of a fully...

154

Frontiers in Disease Therapies UCSB's integration of critical aspects of biological engineering (drug delivery, systems biology, biomateri-  

E-Print Network [OSTI]

the many diseases that UCSB has cross-disciplinary efforts in, including cancer, diabetes, PTSD, Alzheimer targeting therapeutics to cancer cells while sparing healthy ones. In cancer and diabetes, another failure diabetic patients using closed-loop devices in clinical trials. For more insight into our approach

Akhmedov, Azer

155

Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport  

E-Print Network [OSTI]

Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

Tang, Hua, 1972-

2002-01-01T23:59:59.000Z

156

Mining data on usage of electronic nicotine delivery systems (ENDS) from YouTube videos  

E-Print Network [OSTI]

systems (ENDS) from YouTube videos My Hua, Henry Yip, PrueENDS) and conventional cigarettes in YouTube videos.Methods Video data from YouTube videos were analysed to

Talbot, Prue

2013-01-01T23:59:59.000Z

157

Chemical penetration enhancers and in situ-forming reservoirs for trans-tympanic drug delivery : progress toward improved treatment of Otitis media  

E-Print Network [OSTI]

Otitis media (OM) is the most common specifically-treated childhood disease in the United States. The widespread use of systemic antibiotics against a disease of such high incidence is believed to be a driving force behind ...

Simons, Emmanuel John

2008-01-01T23:59:59.000Z

158

E-Print Network 3.0 - amplifies stent-based drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

IN STENT-BASED DRUG DELIVERY Giuseppe Pontrelli*, Filippo de Monte** *IAC... . Hwang, D. Wu, E.R. Edelman, Physiological transport forces govern drug...

159

E-Print Network 3.0 - anticancer drug pump Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Therapeutic Delivery (2010) 1(2), 323334 Special FocuS: oncology Summary: drug efflux pumps, increasing drug metabolism, enhancing self-repairing ability or expressing altered......

160

Hollow-waveguide delivery systems for high-power, industrial CO2 lasers  

E-Print Network [OSTI]

. In addition, these expensive systems are cumbersome in terms of their ability to gain access to remote at the ends of a hollow fiber. Hollow metallic2,3 and dielectric waveguides4 with air cooling have been used, however, are considerably higher, and therefore hollow fibers need to be upgraded with special cooling

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Characterization of oxides for electrical delivery systems. Annual report, September 1991-August 1992  

SciTech Connect (OSTI)

The report identifies an appropriate processing technique for thin film solid oxide fuels cells (SOFC`s) operating at 600-800 deg C, and develops and characterizes compositions within the La-Sr-Co-Fe-O (LSCF) system for SOFC cathode applications at intermediate temperatures.

Anderson, H.U.; Nasrallah, M.M.

1992-10-01T23:59:59.000Z

162

One System Integrated Project Team: Retrieval and Delivery of Hanford Tank Wastes for Vitrification in the Waste Treatment Plant - 13234  

SciTech Connect (OSTI)

The One System Integrated Project Team (IPT) was formed in late 2011 as a way for improving the efficiency of delivery and treatment of highly radioactive waste stored in underground tanks at the U.S. Department of Energy's (DOE's) 586-square-mile Hanford Site in southeastern Washington State. The purpose of the One System IPT is to improve coordination and integration between the Hanford's Waste Treatment Plant (WTP) contractor and the Tank Operations Contractor (TOC). The vision statement is: One System is a WTP and TOC safety-conscious team that, through integrated management and implementation of risk-informed decision and mission-based solutions, will enable the earliest start of safe and efficient treatment of Hanford's tank waste, to protect the Columbia River, environment and public. The IPT is a formal collaboration between Bechtel National, Inc. (BNI), which manages design and construction of the WTP for the U.S. Department of Energy's Office of River Protection (DOEORP), and Washington River Protection Solutions (WRPS), which manages the TOC for ORP. More than fifty-six (56) million gallons of highly radioactive liquid waste are stored in one hundred seventy-seven (177) aging, underground tanks. Most of Hanford's waste tanks - one hundred forty-nine (149) of them - are of an old single-shell tank (SST) design built between 1944 and 1964. More than sixty (60) of these tanks have leaked in the past, releasing an estimated one million gallons of waste into the soil and threatening the nearby Columbia River. There are another twenty-eight (28) new double-shelled tanks (DSTs), built from 1968 to 1986, that provide greater protection to the environment. In 1989, DOE, the U.S. Environmental Protection Agency (EPA), and the Washington State Department of Ecology (Ecology) signed a landmark agreement that required Hanford to comply with federal and state environmental standards. It also paved the way for agreements that set deadlines for retrieving the tank wastes and for building and operating the WTP. The tank wastes are the result of Hanford's nearly fifty (50) years of plutonium production. In the intervening years, waste characteristics have been increasingly better understood. However, waste characteristics that are uncertain and will remain as such represent a significant technical challenge in terms of retrieval, transport, and treatment, as well as for design and construction of WTP. What also is clear is that the longer the waste remains in the tanks, the greater the risk to the environment and the people of the Pacific Northwest. The goal of both projects - tank operations and waste treatment - is to diminish the risks posed by the waste in the tanks at the earliest possible date. About two hundred (200) WTP and TOC employees comprise the IPT. Individual work groups within One System include Technical, Project Integration and Controls, Front-End Design and Project Definition, Commissioning, Nuclear Safety and Engineering Systems Integration, and Environmental Safety and Health and Quality Assurance (ESH and QA). Additional functions and team members will be added as the WTP approaches the operational phase. The team has undertaken several initiatives since its formation to collaborate on issues: (1) alternate scenarios for delivery of wastes from the tank farms to WTP; (2) improvements in managing Interface Control Documents; (3) coordination on various technical issues, including the Defense Nuclear Facilities Nuclear Safety Board's Recommendation 2010-2; (4) deployment of the SmartPlant{sup R} Foundation-Configuration Management System; and (5) preparation of the joint contract deliverable of the Operational Readiness Support Plan. (authors)

Harp, Benton J. [U.S. Department of Energy, Office of River Protection, Post Office Box 550, Richland, Washington 99352 (United States)] [U.S. Department of Energy, Office of River Protection, Post Office Box 550, Richland, Washington 99352 (United States); Kacich, Richard M. [Bechtel National, Inc., 2435 Stevens Center Place, Richland, Washington 99354 (United States)] [Bechtel National, Inc., 2435 Stevens Center Place, Richland, Washington 99354 (United States); Skwarek, Raymond J. [Washington River Protection Solutions LLC, Post Office Box 850, Richland, Washington 99352 (United States)] [Washington River Protection Solutions LLC, Post Office Box 850, Richland, Washington 99352 (United States)

2013-07-01T23:59:59.000Z

163

One System Integrated Project Team: Retrieval And Delivery Of The Hanford Tank Wastes For Vitrification In The Waste Treatment Plant  

SciTech Connect (OSTI)

The One System Integrated Project Team (IPT) was formed in late 2011 as a way for improving the efficiency of delivery and treatment of highly radioactive waste stored in underground tanks at the U.S. Department of Energy's (DOE's) 586-square-mile Hanford Site in southeastern Washington State. The purpose of the One System IPT is to improve coordination and integration between the Hanford's Waste Treatment Plant (WTP) contractor and the Tank Operations Contractor (TOC). The vision statement is: One System is a WTP and TOC safety conscious team that, through integrated management and implementation of risk-informed decision and mission-based solutions, will enable the earliest start of safe and efficient treatment of Hanford's tank waste, to protect the Columbia River, environment and public. The IPT is a formal collaboration between Bechtel National, Inc. (BNI), which manages design and construction of the WTP for the U.S. Department of Energy's Office of River Protection (DOEORP), and Washington River Protection Solutions (WRPS), which manages the TOC for ORP. More than fifty-six (56) million gallons of highly radioactive liquid waste are stored in one hundred seventy-seven (177) aging, underground tanks. Most of Hanford's waste tanks - one hundred forty-nine (149) of them - are of an old single-shell tank (SST) design built between 1944 and 1964. More than sixty (60) of these tanks have leaked in the past, releasing an estimated one million gallons of waste into the soil and threatening the nearby Columbia River. There are another twenty-eight (28) new double-shelled tanks (DSTs), built from 1968 to 1986, that provide greater protection to the environment. In 1989, DOE, the U.S. Environmental Protection Agency (EPA), and the Washington State Department of Ecology (Ecology) signed a landmark agreement that required Hanford to comply with federal and state environmental standards. It also paved the way for agreements that set deadlines for retrieving the tank wastes and for building and operating the WTP. The tank wastes are the result of Hanford's nearly fifty (50) years of plutonium production. In the intervening years, waste characteristics have been increasingly better understood. However, waste characteristics that are uncertain and will remain as such represent a significant technical challenge in terms of retrieval, transport, and treatment, as well as for design and construction ofWTP. What also is clear is that the longer the waste remains in the tanks, the greater the risk to the environment and the people of the Pacific Northwest. The goal of both projects - tank operations and waste treatment - is to diminish the risks posed by the waste in the tanks at the earliest possible date. About two hundred (200) WTP and TOC employees comprise the IPT. Individual work groups within One System include Technical, Project Integration & Controls, Front-End Design & Project Definition, Commissioning, Nuclear Safety & Engineering Systems Integration, and Environmental Safety and Health and Quality Assurance (ESH&QA). Additional functions and team members will be added as the WTP approaches the operational phase. The team has undertaken several initiatives since its formation to collaborate on issues: (1) alternate scenarios for delivery of wastes from the tank farms to WTP; (2) improvements in managing Interface Control Documents; (3) coordination on various technical issues, including the Defense Nuclear Facilities Nuclear Safety Board's Recommendation 2010-2; (4) deployment of the SmartPlant? Foundation-configuration Management System; and (5) preparation of the joint contract deliverable of the Operational Readiness Support Plan.

Harp, Benton J. [Department of Energy, Office of River Protection, Richland, Washington (United States); Kacich, Richard M. [Bechtel National, Inc., Richland, WA (United States); Skwarek, Raymond J. [Washington River Protection Solutions LLC, Richland, WA (United States)

2012-12-20T23:59:59.000Z

164

Analysis of the Texas A&M University System's Construction Project Delivery Method Performance: CMAR and CSP.  

E-Print Network [OSTI]

??In recent decades, the use of construction manager-at-risk (CMAR) has surged as an innovative construction project delivery method in comparison to traditional competitive bid procurement… (more)

Neidert, Andrew

2012-01-01T23:59:59.000Z

165

Cybersecurity for Energy Delivery Systems (CEDS) Peer Review August 5-7 |  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power Systems EngineeringDepartmentSmart GridThird QuarterintoCurrent TestMayBlogsDepartment

166

Comments of Cisco Systems to Office of Electricity Delivery and Energy  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power Systems EngineeringDepartment of4CenterPointChristinaClayCoalofFrontierfrom theBaltimore

167

E-Print Network 3.0 - advocates expanded delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

POLICY AND MANAGEMENT JULY 14, 2010 Summary: DELIVERY SYSTEM REDESIGN The US health care delivery system is expensive, fragmented, highly decentralized... , efficient, and...

168

The Impact of the Katy Management of Automated Curriculum System on Planning for Learning, Delivery of Instruction and Evaluation of Student Learning as Perceived by Teachers in the Katy Independent School District in Texas  

E-Print Network [OSTI]

The purpose of this study was to determine teachers’ perceptions of the relationship of the Katy Management of Automated Curriculum (KMAC) system developed by Katy ISD in Katy, Texas, on planning for learning, delivery of instruction and evaluation...

Hogue, Sharon L.

2011-10-21T23:59:59.000Z

169

Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs  

E-Print Network [OSTI]

Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

Wu, Peter I-Kung

2007-01-01T23:59:59.000Z

170

Drug delivery device for bladder disorders  

E-Print Network [OSTI]

Several pathologies associated with the bladder have wide impacts on society. Overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS) are chronic urological conditions characterized by pain, ...

Lee, Heejin, 1976-

2009-01-01T23:59:59.000Z

171

Physicochemical investigations of a drug delivery oscillator  

E-Print Network [OSTI]

75 mM Glucose/10 % MAA /kmarble= 0.00199 s-1 I = 50 mM (50 mM NaCl+0 mM CaCl2) I = 95 mM (50 mM NaCl + 15 mM CaCl2) I = 155 mM (50 mM NaCl+ 35 mM CaCl2) I = 155 mM (155 mM NaCl+ 0 mM CaCl2) p H Device Membrane - Hydrogel N...4.6 4.7 4.8 4.9 5 5.1 5.2 5.3 5.4 0 0.2 0.4 0.6 0.8 1 Time (Days) p H Glucose Gluconic acid Gluconic acid Gluconate- + H+ H+ + CaCO3 Ca 2+ + HCO3- H+ + HCO3- H2CO3 pKa = 6.37 H2CO3 CO2 ? + H2O pKa = 3.6 ? Buffer Build-Up Affects...

Bhalla, A. S.; Siegel, R. A.

2006-10-27T23:59:59.000Z

172

Self-assembled pentablock copolymers for selective and sustained gene delivery  

SciTech Connect (OSTI)

The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

Zhang, Bingqi

2011-05-15T23:59:59.000Z

173

Gaseous Hydrogen Delivery Breakout - Strategic Directions for...  

Broader source: Energy.gov (indexed) [DOE]

Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop...

174

A client management system for criminal justice referrals to drug abuse treatment  

E-Print Network [OSTI]

. These modalities included methadone maintenance (MM), outpatient drug-free (DF), therapeutic community (TC), and short-term detoxification (DT). In a review of findings in 1979, Sel ls described each of the four modalities. Methadone maintenance programs... over the years of research. Therapeutic communities are typically residential, drug-free programs offering 24-hour care and they concentrate on rehabilitation through resocialization of the addict toward more adaptive and productive pursuits. Drug...

Pate, Wayland Gordon

2012-06-07T23:59:59.000Z

175

Macro-System Model: A Federated Object Model for Cross-Cutting Analysis of Hydrogen Production, Delivery, Consumption and Associated Emissions; Preprint  

SciTech Connect (OSTI)

It is commonly accepted that the introduction of hydrogen as an energy carrier for light-duty vehicles involves concomitant technological development of infrastructure elements, such as production, delivery, and consumption, all associated with certain emission levels. To analyze these at a system level, the suite of corresponding models developed by the United States Department of Energy and involving several national laboratories is combined in one macro-system model (MSM). The macro-system model is being developed as a cross-cutting analysis tool that combines a set of hydrogen technology analysis models. Within the MSM, a federated simulation framework is used for consistent data transfer between the component models. The framework is built to suit cross-model as well as cross-platform data exchange and involves features of 'over-the-net' computation.

Ruth, M.; Diakov, V.; Goldsby, M. E.; Sa, T. J.

2010-12-01T23:59:59.000Z

176

Gaseous Hydrogen Delivery Breakout  

E-Print Network [OSTI]

Gaseous Hydrogen Delivery Breakout Strategic Directions for Hydrogen Delivery Workshop May 7 detection Pipeline Safety: odorants, flame visibility Compression: cost, reliability #12;Breakout Session goal of a realistic, multi-energy distribution network model Pipeline Technology Improved field

177

Articulating feedstock delivery device  

DOE Patents [OSTI]

A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

Jordan, Kevin

2013-11-05T23:59:59.000Z

178

The influence of oscillating electromagnetic fields on membrane structure and function: Synthetic liposome and natural membrane bilayer systems with direct application to the controlled delivery of chemical agents  

SciTech Connect (OSTI)

Investigations have been conducted to determine if an imposed electromagnetic field can influence membrane transport, and ion and drug permeability in both synthetic and natural cell membrane systems. Microwave fields enhance accumulation of sodium in the lymphocyte and induce protein shedding at Tc. Microwaves also trigger membrane permeability of liposome systems under specific field exposure conditions. Sensitivity varies in a defined way in bilayers displaying a membrane structural phase transition temperature, Tc; maximal release was observed at or near Tc. Significantly, liposome systems without a membrane phase transition were also found to experience permeability increases but, in contrast, this response was temperature independent. The above results indicate that field-enhanced drug release occurs in liposome vesicles that possess a Tc as well as non-Tc liposomes. Additional studies extend non-Tc liposome responses to the in vivo case in which microwaves trigger Gentamicin release from a liposome depot'' placed subcutaneously in the rat hind leg. In addition, evidence is provided that cell surface sequestered liposomes can be triggered by microwave fields to release drugs directly into target cells. 24 refs., 6 figs.

Liburdy, R.P.; de Manincor, D.; Fingado, B.

1989-09-01T23:59:59.000Z

179

Systems level characterizations of single and combination drug mechanisms of action in vitro and in vivo  

E-Print Network [OSTI]

Small molecule characterization is a critical limiting step in cancer drug development. At the present time, high throughput screens of natural products and combinatorial synthesis libraries generate more pharmaceutical ...

Pritchard, Justin (Justin Robert)

2012-01-01T23:59:59.000Z

180

Comparison of Fusion Imaging Using a Combined SPECT/CT System and Intra-arterial CT: Assessment of Drug Distribution by an Implantable Port System in Patients Undergoing Hepatic Arterial Infusion Chemotherapy  

SciTech Connect (OSTI)

Hepatic arterial infusion (HAI) chemotherapy is effective for treating primary and metastatic carcinoma of the liver. We compared the perfusion patterns of HAI chemotherapy on intra-arterial port-catheter computed tomography (iapc-CT) and fused images obtained with a combined single-photon emission computed tomography/computed tomography (SPECT/CT) system. We studied 28 patients with primary or metastatic carcinoma of the liver who bore an implantable HAI port system. All underwent abdominal SPECT using Tc-99m-MAA (185 Mbq); the injection rate was 1 mL/min, identical to the chemotherapy infusion rate, and 0.5 mL/sec for iapc-CT. Delivery was through an implantable port. We compared the intrahepatic perfusion (IHP) and extrahepatic perfusion (EHP) patterns of HAI chemotherapy on iapc-CT images and fused images obtained with a combined SPECT/CT system. In 23 of 28 patients (82%), IHP patterns on iapc-CT images and fused images were identical. In 5 of the 28 patients (18%), IHP on fusion images was different from IHP on iapc-CT images. EHP was seen on fused images in 12 of the 28 patients (43%) and on iapc-CT images in 8 patients (29%). In 17 patients (61%), upper gastrointestinal endoscopy revealed gastroduodenal mucosal lesions. EHP was revealed on fused images in 10 of these patients; 9 of them manifested gastroduodenal toxicity at the time of subsequent HAI chemotherapy. Fusion imaging using the combined SPECT/CT system reflects the actual distribution of the infused anticancer agent. This information is valuable not only for monitoring adequate drug distribution but also for avoiding potential extrahepatic complications.

Ikeda, Osamu, E-mail: osamu-3643ik@do9.enjoy.ne.jp; Kusunoki, Shinichiroh; Nakaura, Takeshi; Shiraishi, Shinya; Kawanaka, Kouichi; Tomiguchi, Seiji; Yamashita, Yasuyuki [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Department of Diagnostic Radiology (Japan); Takamori, Hiroshi; Chikamoto, Akira; Kanemitsu, Keiichiro [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Gastroenterological Surgery (Japan)

2006-06-15T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Tools for integrating diagnosis in the design process An application to the Common Rail air and fuel delivery systems  

E-Print Network [OSTI]

in current generation automotive systems. However, the activities related to diagnosis (e.g., FMEA generation such as the diagnosability of the system being designed or the analysis of the FMEA (Failure Modes and Effects Analysis

182

Liquid Hydrogen Delivery - Strategic Directions for Hydrogen...  

Broader source: Energy.gov (indexed) [DOE]

Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop Targets, barriers and...

183

912 IEEE TRANSACTIONS ON POWER DELIVERY, VOL. 19, NO. 3, JULY 2004 Robotic Monitoring of Power Systems  

E-Print Network [OSTI]

--Monitoring of electric power systems in real time for reliability, aging status, and presence of incipient faults maintenance for power systems indicate significant potential of this technological approach. Authors discuss--Automated maintenance, distribution power sys- tems, mobile sensing, real-time monitoring, sensor arrays. I

Mamishev, Alexander

184

Main chain acid-degradable polymers for the delivery of bioactive materials  

DOE Patents [OSTI]

Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.

Frechet, Jean M. J. (Oakland, CA); Standley, Stephany M. (Evanston, IL); Jain, Rachna (Milpitas, CA); Lee, Cameron C. (Cambridge, MA)

2012-03-20T23:59:59.000Z

185

Hydrogen Delivery Liquefaction & Compression  

E-Print Network [OSTI]

Hydrogen Delivery Liquefaction & Compression Raymond Drnevich Praxair - Tonawanda, NY Strategic Initiatives for Hydrogen Delivery Workshop - May 7, 2003 #12;2 Agenda Introduction to Praxair Hydrogen Liquefaction Hydrogen Compression #12;3 Praxair at a Glance The largest industrial gas company in North

186

Hydrogen Delivery Options and Issues  

Broader source: Energy.gov (indexed) [DOE]

Eastman Chemical Ferco AEP Thermochem Entergy GE Framatome Stuart Energy APCi Chevron Praxair Exxonmobil BOC BP H2A Delivery Goals * Develop spreadsheet database on delivery...

187

128 IEEE Transactionson Power Delivery, Vol. 9, No. 1, January 1994 SUNBURST-A Networkof GIC Monitoring Systems  

E-Print Network [OSTI]

Monitoring Systems Richard T. Byerly Electric Research Washington, DC StateCollege, PA Robert L.Lesher Joseph W. Porter Member, IEEE Fellow, IEEE Fellow, IEEE ElectricResearch Electric Power and Management, Inc. Research Institute and Management, Inc. StateCollege, PA Abstract The Electric Power Research Institute has

Schrijver, Karel

188

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling  

E-Print Network [OSTI]

Despite efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain unclear. Here we examine cellular uptake of short ...

Sahay, Gaurav

189

Asynchronous broadcast for ordered delivery between compute nodes in a parallel computing system where packet header space is limited  

DOE Patents [OSTI]

Disclosed is a mechanism on receiving processors in a parallel computing system for providing order to data packets received from a broadcast call and to distinguish data packets received at nodes from several incoming asynchronous broadcast messages where header space is limited. In the present invention, processors at lower leafs of a tree do not need to obtain a broadcast message by directly accessing the data in a root processor's buffer. Instead, each subsequent intermediate node's rank id information is squeezed into the software header of packet headers. In turn, the entire broadcast message is not transferred from the root processor to each processor in a communicator but instead is replicated on several intermediate nodes which then replicated the message to nodes in lower leafs. Hence, the intermediate compute nodes become "virtual root compute nodes" for the purpose of replicating the broadcast message to lower levels of a tree.

Kumar, Sameer

2010-06-15T23:59:59.000Z

190

Development of a polylactic acid (PLA) polymer with an acid-sensitive N-ethoxybenzylimidazole (NEBI) crosslinker as a drug delivery system  

E-Print Network [OSTI]

of a Polylactic Acid (PLA) Polymer with an Acid-Sensitive N-of Poly-lactic Acid (PLA) and N- ethoxybenzylimidazoles (2 Poly-lactic Acid (PLA) and Functionalized Derivatives of

Hang, Leibniz Fangtinq

2012-01-01T23:59:59.000Z

191

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity  

SciTech Connect (OSTI)

Drug-induced liver injury (DILI) is the major cause for liver failure and post-marketing drug withdrawals. Due to species-specific differences in hepatocellular function, animal experiments to assess potential liabilities of drug candidates can predict hepatotoxicity in humans only to a certain extent. In addition to animal experimentation, primary hepatocytes from rat or human are widely used for pre-clinical safety assessment. However, as many toxic responses in vivo are mediated by a complex interplay among different cell types and often require chronic drug exposures, the predictive performance of hepatocytes is very limited. Here, we established and characterized human and rat in vitro three-dimensional (3D) liver co-culture systems containing primary parenchymal and non-parenchymal hepatic cells. Our data demonstrate that cells cultured on a 3D scaffold have a preserved composition of hepatocytes, stellate, Kupffer and endothelial cells and maintain liver function for up to 3 months, as measured by the production of albumin, fibrinogen, transferrin and urea. Additionally, 3D liver co-cultures maintain cytochrome P450 inducibility, form bile canaliculi-like structures and respond to inflammatory stimuli. Upon incubation with selected hepatotoxicants including drugs which have been shown to induce idiosyncratic toxicity, we demonstrated that this model better detected in vivo drug-induced toxicity, including species-specific drug effects, when compared to monolayer hepatocyte cultures. In conclusion, our results underline the importance of more complex and long lasting in vitro cell culture models that contain all liver cell types and allow repeated drug-treatments for detection of in vivo-relevant adverse drug effects. - Highlights: ? 3D liver co-cultures maintain liver specific functions for up to three months. ? Activities of Cytochrome P450s remain drug- inducible accross three months. ? 3D liver co-cultures recapitulate drug-induced liver toxicity observed in vivo. ? 3D liver co-cultures can detect species-specific drug toxicity observed in vivo. ? This in vitro model may improve assessment of human relevance of preclinical findings.

Kostadinova, Radina; Boess, Franziska [Non-Clinical Safety, Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Building 73 / Room 117b, 4070 Basel (Switzerland); Applegate, Dawn [RegeneMed, 9855 Towne Centre Drive Suite 200, San Diego, CA 92121 (United States); Suter, Laura; Weiser, Thomas; Singer, Thomas [Non-Clinical Safety, Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Building 73 / Room 117b, 4070 Basel (Switzerland); Naughton, Brian [RegeneMed, 9855 Towne Centre Drive Suite 200, San Diego, CA 92121 (United States); Roth, Adrian, E-mail: adrian_b.roth@roche.com [Non-Clinical Safety, Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Building 73 / Room 117b, 4070 Basel (Switzerland)

2013-04-01T23:59:59.000Z

192

Understanding barriers to efficient nucleic acid delivery with bioresponsive block copolymers  

E-Print Network [OSTI]

The delivery of nucleic acids has the potential to revolutionize medicine by allowing previously untreatable diseases to be clinically addressed. Viral delivery systems have been held back by immunogenicity and toxicity ...

Bonner, Daniel Kenneth

2012-01-01T23:59:59.000Z

193

Hydrogen Delivery - Basics | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Delivery Hydrogen Delivery - Basics Hydrogen Delivery - Basics Photo of light-duty vehicle at hydrogen refueling station. Infrastructure is required to move hydrogen from the...

194

Kraft black liquor delivery systems  

SciTech Connect (OSTI)

Improvement of spray nozzles for black liquor injection into kraft recovery furnaces is expected to result from obtaining a controlled, well-defined droplet size distribution. Work this year has centered on defining the capabilities of commercial black liquor nozzles currently in use. Considerations of the observed mechanism of droplet formation suggest a major revision is needed in the theory of how droplets form from these nozzles. High resolution, high sensitivity video has been shown to be superior to flash x-ray as a technique for measuring the droplet size distribution as well as the formation history. An environmentally sound spray facility capable of spraying black liquor at temperatures up to normal firing conditions is being constructed before data acquisition continues. Preliminary correlations have been developed between liquor properties, nozzle design, and droplet size. Three aspects of nozzle design have been investigated: droplet size distribution, fluid sheet thickness, and flow and pressure drop characteristics. The standard deviation about the median droplet size for black liquor is nearly the same as the for a wide variety of other fluids and nozzle types. Preliminary correlation for fluid sheet thickness on the plate of a splashplate nozzle show the strong similarities of black liquor to other fluids. The flow and pressure drop characteristic of black liquor nozzle, follow a simple two-term relationship similar to other flow devices. This means that in routine mill operation of black liquor nozzles only the fluid acceleration in the nozzle is important, viscous losses are quiet small. 21 refs., 53 figs., 10 tabs.

Adams, T.N.; Empie, H.L.; Obuskovic, N.; Spielbauer, T.M.

1990-02-01T23:59:59.000Z

195

Experimental and computational investigations of therapeutic drug release from biodegradable poly(lactide-co-glycolide) (plg) microspheres  

E-Print Network [OSTI]

The need to tailor release-rate profiles from polymeric microspheres remains one of the leading challenges in controlled drug delivery. Microsphere size, which has a significant effect on drug release rate, can potentially be varied to design a...

Berchane, Nader Samir

2009-05-15T23:59:59.000Z

196

Measurements of lateral penumbra for uniform scanning proton beams under various beam delivery conditions and comparison to the XiO treatment planning system  

SciTech Connect (OSTI)

Purpose: The main purposes of this study were to (1) investigate the dependency of lateral penumbra (80%–20% distance) of uniform scanning proton beams on various factors such as air gap, proton range, modulation width, compensator thickness, and depth, and (2) compare the lateral penumbra calculated by a treatment planning system (TPS) with measurements.Methods: First, lateral penumbra was measured using solid–water phantom and radiographic films for (a) air gap, ranged from 0 to 35 cm, (b) proton range, ranged from 8 to 30 cm, (c) modulation, ranged from 2 to 10 cm, (d) compensator thickness, ranged from 0 to 20 cm, and (e) depth, ranged from 7 to 15 cm. Second, dose calculations were computed in a virtual water phantom using the XiO TPS with pencil beam algorithm for identical beam conditions and geometrical configurations that were used for the measurements. The calculated lateral penumbra was then compared with the measured one for both the horizontal and vertical scanning magnets of our uniform scanning proton beam delivery system.Results: The results in the current study showed that the lateral penumbra of horizontal scanning magnet was larger (up to 1.4 mm for measurement and up to 1.0 mm for TPS) compared to that of vertical scanning magnet. Both the TPS and measurements showed an almost linear increase in lateral penumbra with increasing air gap as it produced the greatest effect on lateral penumbra. Lateral penumbra was dependent on the depth and proton range. Specifically, the width of lateral penumbra was found to be always lower at shallower depth than at deeper depth within the spread out Bragg peak (SOBP) region. The lateral penumbra results were less sensitive to the variation in the thickness of compensator, whereas lateral penumbra was independent of modulation. Overall, the comparison between the results of TPS with that of measurements indicates a good agreement for lateral penumbra, with TPS predicting higher values compared to measurements.Conclusions: Lateral penumbra of uniform scanning proton beams depends on air gap, proton range, compensator thickness, and depth, whereas lateral penumbra is not dependent on modulation. The XiO TPS typically overpredicted lateral penumbra compared to measurements, within 1 mm for most cases, but the difference could be up to 2.5 mm at a deep depth and large air gap.

Rana, Suresh; Zeidan, Omar; Ramirez, Eric; Rains, Michael; Gao, Junfang; Zheng, Yuanshui [Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, Oklahoma 73142 (United States)] [Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, Oklahoma 73142 (United States)

2013-09-15T23:59:59.000Z

197

Gaseous Hydrogen Delivery Breakout- Strategic Directions for Hydrogen Delivery Workshop  

Broader source: Energy.gov [DOE]

Targets, barriers and research and development priorities for gaseous delivery of hydrogen through hydrogen and natural gas pipelines.

198

Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals  

DOE Patents [OSTI]

A method and system for tailoring treatment regimens to individual patients with diseased cells exhibiting evolution of resistance to such treatments. A mathematical model is provided which models rates of population change of proliferating and quiescent diseased cells using cell kinetics and evolution of resistance of the diseased cells, and pharmacokinetic and pharmacodynamic models. Cell kinetic parameters are obtained from an individual patient and applied to the mathematical model to solve for a plurality of treatment regimens, each having a quantitative efficacy value associated therewith. A treatment regimen may then be selected from the plurlaity of treatment options based on the efficacy value.

Gardner, Shea Nicole (San Leandro, CA)

2007-10-23T23:59:59.000Z

199

STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 2009/109/109/109/10 Annual Delivery Report  

E-Print Network [OSTI]

STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 2009/109/109/109/10 0 Annual Delivery Report 2009/10 August 2010 #12;STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery

200

Hydrogen Delivery Mark Paster  

E-Print Network [OSTI]

Liquids (e.g. ethanol etc.) ­ Truck: HP Gas & Liquid Hydrogen ­ Regional Pipelines ­ Breakthrough Hydrogen;Delivery Key Challenges · Pipelines ­ Retro-fitting existing NG pipeline for hydrogen ­ Utilizing existing NG pipeline for Hythane with cost effective hydrogen separation technology ­ New hydrogen pipeline

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Hydrogen Delivery- Current Technology  

Broader source: Energy.gov [DOE]

Hydrogen is transported from the point of production to the point of use via pipeline, over the road in cryogenic liquid trucks or gaseous tube trailers, or by rail or barge. Read on to learn more about current hydrogen delivery and storage technologies.

202

Hydrogen Delivery Liquefaction and Compression  

Broader source: Energy.gov [DOE]

Hydrogen Delivery Liquefaction and Compression - Overview of commercial hydrogen liquefaction and compression and opportunities to improve efficiencies and reduce cost.

203

Aggressive Underwriting and Smart Program Delivery | Department...  

Energy Savers [EERE]

Aggressive Underwriting and Smart Program Delivery Aggressive Underwriting and Smart Program Delivery Presents information about loan underwriting funding approaches and...

204

Estimating changes in urban ozone concentrations due to life cycle emissions from hydrogen transportation systems  

E-Print Network [OSTI]

production with gaseous hydrogen pipeline delivery, and2) central hydrogen production with pipeline delivery; and (Central hydrogen production with pipeline delivery systems

Wang, Guihua; Ogden, Joan M; Chang, Daniel P.Y.

2007-01-01T23:59:59.000Z

205

Apatite-Polymer Composites for the Controlled Dual Delivery of BMP-2 and BMP-6 for Bone Tissue Engineering  

E-Print Network [OSTI]

The release of growth factors from tissue engineering scaffolds provides signals that influence the migration, differentiation, and proliferation of cells. The incorporation of a drug delivery platform that is capable of ...

Yong, Tseh-Hwan

206

Hydrogen Delivery Technologies and Pipeline Transmission of Hydrogen  

E-Print Network [OSTI]

Hydrogen Delivery Technologies and Systems Pipeline Transmission of Hydrogen Strategic Initiatives, and Infrastructure Technologies Program #12;Pipeline Transmission of Hydrogen --- 2 Copyright: Design & Operation development) #12;Pipeline Transmission of Hydrogen --- 3 Copyright: Future H2 Infrastructure Wind Powered

207

An alternative approach based on microfluidics to study drug metabolism and toxicity using liver and intestinal tissue.  

E-Print Network [OSTI]

??A new in vitro system has been developed to study drug metabolism, drug-drug interactions and interorgan communication. As the ultimate goal was a system which… (more)

Midwoud, Paul Marcel van

2010-01-01T23:59:59.000Z

208

Functionalization of nanocarriers for efficient combination drug delivery  

E-Print Network [OSTI]

the-art synthetic stealth materials. Biodistribution studystealth moieties can be developed to mimic our bodies’ endogenous materials

Hu, Che-Ming Jack

2011-01-01T23:59:59.000Z

209

Silicon microneedles array with biodegradable tips for transdermal drug delivery  

E-Print Network [OSTI]

This paper presents the fabrication process, characterization results and basic functionality of silicon microneedles array with biodegradable tips. In order to avoid the main problems related to silicon microneedles : broking of the top part of the needles inside the skin, a simple solution can be fabrication of microneedles array with biodegradable tips. The silicon microneedles array was fabricated by using reactive ion etching while the biodegradable tips were performed using and anodization process that generates selectively porous silicon only on the top part of the skin. The paper presents also the results of in vitro release of calcein using microneedles array with biodegradable tips

Chen, B; Tay, Francis; Wong, Y T; Iliescu, C

2008-01-01T23:59:59.000Z

210

Functionalization of nanocarriers for efficient combination drug delivery  

E-Print Network [OSTI]

proton resonance peaks of DOX-PLA (upper panel)and CPT-PLA (lower panel) Fig.cores consisting of: (A) DOX-PLA conjugates, (B) CPT-PLA

Hu, Che-Ming Jack

2011-01-01T23:59:59.000Z

211

Molecule Nanoweaver Improves Drug Delivery and Treatment Efficacy - Energy  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment SurfacesResource ProgramModification andinterface of water.

212

Artificial Cells for Advanced Drug Delivery - Energy Innovation Portal  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout theOFFICEAmesApplication2Argonne National4

213

Protein-Based Nanomedicine Platforms for Drug Delivery. | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 - SeptemberMicroneedlesAdvanced Photon Source The Superpowerrelated

214

Apoferritin-based nanomedicine platform for drug delivery: equilibrium  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone by E-mailRadioimmunotherapy of Cancers. | EMSLbinding study

215

Targeted Drug Delivery To Leukocytes with ICAM-1 Derived Peptides  

E-Print Network [OSTI]

cells by receptor mediated endocytosis and passive diffusion, respectively. High hydrophobicity of DOX-cIBR was proposed to be responsible for its energy-independent entry (chapter 2). To check the effect of hydrophobicity on internalization, two...

Majumdar, Sumit

2008-07-15T23:59:59.000Z

216

Electro-osmotically driven liquid delivery method and apparatus  

DOE Patents [OSTI]

Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.

Rakestraw, David J. (Fremont, CA); Anex, Deon S. (Livermore, CA); Yan, Chao (Pleasanton, CA); Dadoo, Rajeev (Stanford, CA); Zare, Richard N. (Stanford, CA)

1999-01-01T23:59:59.000Z

217

Capital Projects Delivery Procedures Manual  

E-Print Network [OSTI]

1 Capital Projects Delivery Procedures Manual September 4, 2008 Office of the CFO #12;2 Page I of the Capital Budget 11 B. Budget Approval 12 C. Setting Up Capital Projects 13 III. Procedures for Design ­ Office of the Chief Financial Officer Financial Policies and Procedures for the Capital Project Delivery

Alpay, S. Pamir

218

Hydrogen Production and Delivery Research  

SciTech Connect (OSTI)

In response to DOE's Solicitation for Grant Applications DE-PS36-03GO93007, 'Hydrogen Production and Delivery Research', SRI International (SRI) proposed to conduct work under Technical Topic Area 5, Advanced Electrolysis Systems; Sub-Topic 5B, High-Temperature Steam Electrolysis. We proposed to develop a prototype of a modular industrial system for low-cost generation of H{sub 2} (<$2/kg) by steam electrolysis with anodic depolarization by CO. Water will be decomposed electrochemically into H{sub 2} and O{sub 2} on the cathode side of a high-temperature electrolyzer. Oxygen ions will migrate through an oxygen-ion-conductive solid oxide electrolyte. Gas mixtures on the cathode side (H{sub 2} + H{sub 2}O) and on the anode side (CO + CO{sub 2}) will be reliably separated by the solid electrolyte. Depolarization of the anodic process will decrease the electrolysis voltage, and thus the electricity required for H{sub 2} generation and the cost of produced H{sub 2}. The process is expected to be at least 10 times more energy-efficient than low-temperature electrolysis and will generate H{sub 2} at a cost of approximately $1-$1.5/kg. The operating economics of the system can be made even more attractive by deploying it at locations where waste heat is available; using waste heat would reduce the electricity required for heating the system. Two critical targets must be achieved: an H{sub 2} production cost below $2/kg, and scalable design of the pilot H{sub 2} generation system. The project deliverables would be (1) a pilot electrolysis system for H{sub 2} generation, (2) an economic analysis, (3) a market analysis, and (4) recommendations and technical documentation for field deployment. DOE was able to provide only 200K out of 1.8M (or about 10% of awarded budget), so project was stopped abruptly.

Iouri Balachov, PhD

2007-10-15T23:59:59.000Z

219

Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating  

E-Print Network [OSTI]

Electrically triggered drug delivery represents an attractive option for actively and remotely controlling the release of a therapeutic from an implantable device (e.g., a “pharmacy-on-a-chip”). Here we report the fabrication ...

Schmidt, Daniel J.

220

Delivery of neuroactive peptide drugs to the brain via intranasal delivery  

E-Print Network [OSTI]

was sampled, placed on ice, and 75?L acetonitrile added to precipitate the plasma proteins. Samples were analysed by HPLC. Leu-Enkephalin analogues The peptides were synthesised by solid phase peptide synthesis with MBHA rink amide resin following Fmoc...

Cros, C. D.; Toth, I.; Blanchfield, J.

2006-10-27T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Electricity Delivery and Energy Reliability PROGRAM DESCRIPTION  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

32 Electricity Delivery and Energy Reliability PROGRAM DESCRIPTION The Office of Electricity Delivery and Energy Reliability (OE) leads national efforts to modernize the electric...

222

Final Report - Hydrogen Delivery Infrastructure Options Analysis...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

- Hydrogen Delivery Infrastructure Options Analysis Final Report - Hydrogen Delivery Infrastructure Options Analysis This report, by the Nexant team, documents an in-depth analysis...

223

Final Report - Hydrogen Delivery Infrastructure Options Analysis  

Broader source: Energy.gov (indexed) [DOE]

pipelines for gaseous hydrogen delivery Option 2: Use of existing natural gas or oil pipelines for gaseous hydrogen delivery Option 3: Use of existing natural gas pipelines...

224

Waste feed delivery planning at Hanford  

SciTech Connect (OSTI)

The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades.

Certa, Paul J.; West, Elizha B.; Rodriguez, Juissepp S.; Hohl, Ted M.; Larsen, Douglas C.; Ritari, Jaakob S.; Kelly, James W.

2013-01-10T23:59:59.000Z

225

Waste Feed Delivery Planning at Hanford - 13232  

SciTech Connect (OSTI)

The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades. (authors)

Certa, Paul J.; Hohl, Ted M.; Kelly, James W.; Larsen, Douglas C.; West, Elizha B.; Ritari, Jaakob S.; Rodriguez, Juissepp S. [Washington River Protection Solutions, LLC, P.O. 850, Richland, WA 99352 (United States)] [Washington River Protection Solutions, LLC, P.O. 850, Richland, WA 99352 (United States)

2013-07-01T23:59:59.000Z

226

Nonviral Vectors for Gene Delivery  

E-Print Network [OSTI]

optimized for gene delivery by varying particle surface chemistry using different coating materials that adsorb to the particle surface during formation. A variety of cationic coating materials were studied and compared to more conventional surfactants used...

Baoum, Abdulgader Ahmed

2011-04-26T23:59:59.000Z

227

Best antibiotics for buccal delivery  

E-Print Network [OSTI]

The purpose of the research was to identify the clinical and commercial benefits of switching from intravenous (IV) to buccal delivery of antibiotics. then, the research continued to select 3-5 antibiotics that best met ...

Goldberg, Manijeh Nazari

2011-01-01T23:59:59.000Z

228

Variable delivery, fixed displacement pump  

DOE Patents [OSTI]

A variable delivery, fixed displacement pump comprises a plurality of pistons reciprocated within corresponding cylinders in a cylinder block. The pistons are reciprocated by rotation of a fixed angle swash plate connected to the pistons. The pistons and cylinders cooperate to define a plurality of fluid compression chambers each have a delivery outlet. A vent port is provided from each fluid compression chamber to vent fluid therefrom during at least a portion of the reciprocal stroke of the piston. Each piston and cylinder combination cooperates to close the associated vent port during another portion of the reciprocal stroke so that fluid is then pumped through the associated delivery outlet. The delivery rate of the pump is varied by adjusting the axial position of the swash plate relative to the cylinder block, which varies the duration of the piston stroke during which the vent port is closed.

Sommars, Mark F. (Sparland, IL)

2001-01-01T23:59:59.000Z

229

Hydrogen Distribution and Delivery Infrastructure  

Fuel Cell Technologies Publication and Product Library (EERE)

This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challen

230

Hydrogen Delivery Infrastructure Options Analysis  

Fuel Cell Technologies Publication and Product Library (EERE)

This report, by the Nexant team, documents an in-depth analysis of seven hydrogen delivery options to identify the most cost-effective hydrogen infrastructure for the transition and long term. The pro

231

Hydrogen Delivery Technology Roadmap, November 2005  

Fuel Cell Technologies Publication and Product Library (EERE)

Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

232

Benchmark Problem: A PK/PD Model and Safety Constraints for Anesthesia Delivery  

E-Print Network [OSTI]

Benchmark Problem: A PK/PD Model and Safety Constraints for Anesthesia Delivery Victor Gan, Guy A of the goals of general anesthesia. In this brief paper we provide a differential equation model of how Introduction General anesthesia is a broad term encompassing the use of drugs to induce and maintain three

Mitchell, Ian

233

Investigation of Volume of Fluids (VOF) Method and System Models for Design of Microfluidic Ink Delivery Apparatus for Dip Pen Nanolithography (DPN)  

E-Print Network [OSTI]

Investigation of Volume of Fluids (VOF) Method and System Models for Design of Microfluidic Ink and manufacture of commercial microfluidic systems called "InkwellsTM". In this study VOF method was used sequence of flow in the different parts of the microfluidic network. Keywords: lab-on-chip, micro

Banerjee, Debjyoti

234

Agenda for the Hydrogen Delivery and Onboard Storage Analysis...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage...

235

A Platform-Based Design Environment for Synthetic Biological Systems  

E-Print Network [OSTI]

in drug pro- duction, biofuels, and drug delivery vessels. In an attempt to standardize this process, and the notion of both "top down" and "bottom up" design styles. 1.1 Requirements In the world of biology one can

Densmore, Douglas

236

Drug Retention Times  

SciTech Connect (OSTI)

The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

Center for Human Reliability Studies

2007-05-01T23:59:59.000Z

237

Drug Retention Times  

SciTech Connect (OSTI)

The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

Center for Human Reliability Studies

2007-05-01T23:59:59.000Z

238

A P2P VIDEO DELIVERY NETWORK (P2P-VDN) Kien Nguyen, Thinh Nguyen  

E-Print Network [OSTI]

A P2P VIDEO DELIVERY NETWORK (P2P-VDN) Kien Nguyen, Thinh Nguyen School of EECS Oregon State University kovchegy@science.oregonstate.edu ABSTRACT Current video streaming and storage systems such as You- per describes a Peer-to-Peer Video Delivery Network (P2P- VDN) that provides both performance

Kovchegov, Yevgeniy

239

Radioisotope Power System Delivery, Ground Support and Nuclear Safety Implementation: Use of the Multi-Mission Radioisotope Thermoelectric Generator for the NASA's Mars Science Laboratory  

SciTech Connect (OSTI)

Radioisotope power systems have been used for over 50 years to enable missions in remote or hostile environments. They are a convenient means of supplying a few milliwatts up to a few hundred watts of useable, long-term electrical power. With regard to use of a radioisotope power system, the transportation, ground support and implementation of nuclear safety protocols in the field is a complex process that requires clear identification of needed technical and regulatory requirements. The appropriate care must be taken to provide high quality treatment of the item to be moved so it arrives in a condition to fulfill its missions in space. Similarly it must be transported and managed in a manner compliant with requirements for shipment and handling of special nuclear material. This presentation describes transportation, ground support operations and implementation of nuclear safety and security protocols for a radioisotope power system using recent experience involving the Multi-Mission Radioisotope Thermoelectric Generator for National Aeronautics and Space Administration’s Mars Science Laboratory, which launched in November of 2011.

S.G. Johnson; K.L. Lively; C.C. Dwight

2014-07-01T23:59:59.000Z

240

A planning and delivery study of a rotational IMRT technique with burst delivery  

SciTech Connect (OSTI)

Purpose: A novel rotational IMRT (rIMRT) technique using burst delivery (continuous gantry rotation with beam off during MLC repositioning) is investigated. The authors evaluate the plan quality and delivery efficiency and accuracy of this dynamic technique with a conventional flat 6 MV photon beam. Methods: Burst-delivery rIMRT was implemented in a planning system and delivered with a 160-MLC linac. Ten rIMRT plans were generated for five anonymized patient cases encompassing head and neck, brain, prostate, and prone breast. All plans were analyzed retrospectively and not used for treatment. Among the varied plan parameters were the number of optimization points, number of arcs, gantry speed, and gantry angle range (alpha) over which the beam is turned on at each optimization point. Combined rotational/step-and-shoot rIMRT plans were also created by superimposing multiple-segment static fields at several optimization points. The rIMRT trial plans were compared with each other and with plans generated using helical tomotherapy and VMAT. Burst-mode rotational IMRT plans were delivered and verified using a diode array, ionization chambers, thermoluminescent dosimeters, and film. Results: Burst-mode rIMRT can achieve plan quality comparable to helical tomotherapy, while the former may lead to slightly better OAR sparing for certain cases and the latter generally achieves slightly lower hot spots. Few instances were found in which increasing the number of optimization points above 36, or superimposing step-and-shoot IMRT segments, led to statistically significant improvements in OAR sparing. Using an additional rIMRT partial arc yielded substantial OAR dose improvements for the brain case. Measured doses from the rIMRT plan delivery were within 4% of the plan calculation in low dose gradient regions. Delivery time range was 228-375 s for single-arc rIMRT 200-cGy prescription with a 300 MU/min dose rate, comparable to tomotherapy and VMAT. Conclusions: Rotational IMRT with burst delivery, whether combined with static fields or not, yields clinically acceptable and deliverable treatment plans.

Kainz, Kristofer; Chen, Guang-Pei; Chang, Yu-Wen; Prah, Douglas; Sharon Qi, X.; Shukla, Himanshu P.; Stahl, Johannes; Allen Li, X. [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States); Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado 80045 (United States); Siemens Oncology Care Systems, Concord, California 94520 (United States); Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States)

2011-09-15T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Strategic Directions for Hydrogen Delivery Workshop Proceedings  

Broader source: Energy.gov [DOE]

Proceedings from the Strategic Directions for Hydrogen Delivery Workshop held May 7-8, 2003 in Washington, DC. Author: Energetics

242

Delivery and Hedging Delivery ties the futures price to the spot price.  

E-Print Network [OSTI]

Delivery and Hedging · Delivery ties the futures price to the spot price. · On the delivery date, the settlement price of the futures contract is determined by the spot price. · Hence, when the delivery period is reached, the futures price should be very close to the spot price. · Changes in futures prices usually

Lyuu, Yuh-Dauh

243

aquifer system california: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

City Environmental Health Services Delivery System The purpose service delivery in California with the aim of providing a foundation for informed decision making about...

244

Proceedings: EPRI Power Delivery Asset Management Workshop: New York City 2003  

SciTech Connect (OSTI)

As part of EPRI's Asset Management Toolkit Project, the first annual EPRI Power Delivery Asset Management Workshop furnished an opportunity for leading utilities, consultants, and academicians to present and review the best practices in power delivery asset management. The workshop focused on current activities, new developments, and future utility needs, bringing together a wide range of domestic and international managers and executives in a forum for open exchange. The workshop covered all power delivery system assets, with emphasis on lowering life-cycle costs, improving asset utilization, and increasing return on capital investment while maintaining high levels of system performance and customer service.

None

2003-07-01T23:59:59.000Z

245

High throughput optical sensor arrays for drug screening  

E-Print Network [OSTI]

In the world of drug discovery, high throughput whole cell assays are a critical step in discovering therapeutically relevant drug compounds [1]. This report details the development of several novel sensor systems capable ...

Harjes, Daniel I

2006-01-01T23:59:59.000Z

246

Analysis of oil-pipeline distribution of multiple products subject to delivery time-windows  

E-Print Network [OSTI]

This dissertation defines the operational problems of, and develops solution methodologies for, a distribution of multiple products into oil pipeline subject to delivery time-windows constraints. A multiple-product oil pipeline is a pipeline system...

Jittamai, Phongchai

2006-04-12T23:59:59.000Z

247

Synthesis and chemical modification of degradable polymers to enhance gene delivery  

E-Print Network [OSTI]

Poly([beta]-amino ester)s are a class of cationic, degradable polymers that have shown significant promise as gene delivery agents, more effective than the state-of-the-art, commercially available non-viral systems. The ...

Zugates, Gregory Thomas

2007-01-01T23:59:59.000Z

248

Twelve-Month Evaluation of UPS Diesel Hybrid Electric Delivery Vans  

SciTech Connect (OSTI)

Results of an NREL study of a parallel hybrid electric-diesel propulsion system in United Parcel Service-operated delivery vans show that the hybrids had higher fuel economy than standard diesel vans.

Lammert, M.

2009-12-01T23:59:59.000Z

249

Opto-acoustic recanilization delivery system  

DOE Patents [OSTI]

Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.

Visuri, Steven R. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Celliers, Peter M. (Berkeley, CA); London, Richard A. (Orinda, CA); Benett, William (Livermore, CA); Broughton, Kathryn (Berkeley, CA); Esch, Victor (San Francisco, CA)

2002-01-01T23:59:59.000Z

250

Autothermal hydrogen storage and delivery systems  

DOE Patents [OSTI]

Processes are provided for the storage and release of hydrogen by means of dehydrogenation of hydrogen carrier compositions where at least part of the heat of dehydrogenation is provided by a hydrogen-reversible selective oxidation of the carrier. Autothermal generation of hydrogen is achieved wherein sufficient heat is provided to sustain the at least partial endothermic dehydrogenation of the carrier at reaction temperature. The at least partially dehydrogenated and at least partially selectively oxidized liquid carrier is regenerated in a catalytic hydrogenation process where apart from an incidental employment of process heat, gaseous hydrogen is the primary source of reversibly contained hydrogen and the necessary reaction energy.

Pez, Guido Peter (Allentown, PA); Cooper, Alan Charles (Macungie, PA); Scott, Aaron Raymond (Allentown, PA)

2011-08-23T23:59:59.000Z

251

Nitrogen oxide delivery systems for biological media  

E-Print Network [OSTI]

Elevated levels of nitric oxide (NO) in vivo are associated with a variety of cellular modifications thought to be mutagenic or carcinogenic. These processes are likely mediated by reactive nitrogen species (RNS) such as ...

Skinn, Brian Thomas

2012-01-01T23:59:59.000Z

252

Cybersecurity Procurement Language for Energy Delivery Systems  

Broader source: Energy.gov (indexed) [DOE]

Engineers (IEEE), the International Society of Automation (ISA), the International Organization for Standardization (ISO), and IEC, which may provide additional information or...

253

Energy Delivery Systems Cybersecurity | Department of Energy  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelinesProvedDecember 2005DepartmentDecember 2011 EMAB MeetingInformationConservation

254

Vulnerability Analysis of Energy Delivery Control Systems  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGYWomen Owned SmallOf The 2012Nuclear GuideReportVictor KaneContractfrom Water0-18381

255

Roadmap to Achieve Energy Delivery Systems Cybersecurity  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power.pdf11-161-LNG |September 15,2015Department ofRequirementsEnergyJDicksonDepartment ofRoadmap

256

Roadmap to Achieve Energy Delivery Systems Cybersecurity  

Office of Environmental Management (EM)

roadmap in support of the Electricity Sub-sector Coordinating Council, Oil and Natural Gas Sector Coordinating Council, and the Government Coordinating Council for Energy under...

257

Cybersecurity Procurement Language for Energy Delivery Systems  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana. DOCUMENTS AVAILABLEReport 2009Site |Documents Available for

258

Energy Delivery Systems Cybersecurity | Department of Energy  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector General Office of Audit| Department ofNon-RoadDepartment of Energy Energy Corps

259

Evaluation of Retrofit Delivery Packages  

SciTech Connect (OSTI)

Residential energy retrofit activities are a critical component of efforts to increase energy efficiency in the U.S. building stock; however, retrofits account for a small percentage of aggregate energy savings at relatively high per unit costs. This report by Building America research team, Alliance for Residential Building Innovation (ARBI), describes barriers to widespread retrofits and evaluates opportunities to improve delivery of home retrofit measures by identifying economies of scale in marketing, energy assessments, and bulk purchasing through pilot programs in portions of Sonoma, Los Angeles, and San Joaquin Counties, CA. These targeted communities show potential and have revealed key strategies for program design, as outlined in the report.

Berman, M.; Smith, P.; Porse, E.

2013-07-01T23:59:59.000Z

260

Sandia National Laboratories: Hydrogen Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -theErik Spoerke SSLS Exhibit atVehicle Technologies On November 9, 2010,Delivery

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Hydrogen Delivery Infrastructure Analysis, Options and Trade...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Analysis, Options and Trade-offs, Transition and Long-term Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs, Transition and Long-term Presentation on Hydrogen...

262

Categorical Exclusion Determinations: Office of Electricity Delivery...  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery and Energy Reliability. DOCUMENTS AVAILABLE FOR DOWNLOAD September 18, 2012 CX-009236: Categorical Exclusion Determination Dynasty Power, Inc. Export...

263

MFRC Training Development & Delivery Program - Bloodstain & Toxicology...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Resource Center (MFRC) Training Development and Delivery Program increases access to forensic science training for publicly funded state and local forensic scientists. Its goals...

264

HST.151 Principles of Pharmacology, Spring 2003  

E-Print Network [OSTI]

An introduction to pharmacology. Topics include mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interactions, and ...

Rosow, Carl E. (Carl Elliott), 1947-

265

An overview of power delivery and laser damage in fibers  

SciTech Connect (OSTI)

Fiber optic delivery systems are an important component of high power laser systems used for applications ranging from laser surgery to industrial cutting and welding. Conventional silica fiber optics may be used to deliver Nd:YAG laser powers in excess of 2,000 W whereas lasers operating beyond 2 {mu}m require non-silica fiber optics. Specifically, IR transmissive fiber optics for Er:YAG (3 {mu}m) or CO{sub 2} (10.6 {mu}m) laser beam delivery require the use of special fiber optics such as sapphire, fluoride or chalcogenide glass, or hollow waveguides. The optical and mechanical properties of these unique guides and their power handling capability are reviewed along with those of silica fibers operating in the UV and near IR wavelength region of the spectrum.

Harrington, J.A. [Rutgers Univ., Piscataway, NJ (United States)

1997-12-01T23:59:59.000Z

266

TIGER -- A technology to improve the delivery capability of nuclear bombs and the survivability of the delivery aircraft  

SciTech Connect (OSTI)

The TIGER (Terminal guided and Extended-Range) Program was initiated in 1972 to study improved delivery capabilities for stockpiled tactical nuclear bombs. The Southeast Asia conflict fostered the development of air-delivered standoff conventional weapons utilizing terminal guidance systems. SNL initiated the TIGER program to determine if current nuclear bombs could be provided with a similarly accurate standoff capabilities. These conventional weapon delivery techniques, while allowing highly accurate attack, generally require entering the target area at high altitude to establish line of sight to the target. In parallel with the TIGER program, system studies analyzed this concept and showed marked improvement in aircraft and weapon survivability with moderate standoff (10--20 km) if low level deliveries (60 m) could be accomplished. As a result of this work, the TIGER program was redirected in early 1974 to demonstrate a standoff bomb with good accuracy (90 m CEP) when delivered from low flying aircraft. This program redirection resulted in the selection of an inertial guidance system to replace the earlier terminal guidance systems. This program was called the Extended-Range Bomb (ERB). In May 1974, a joint Air Force/DOE study identified the desirability of having a single tactical weapon which could be employed against either fixed, preselected targets, or mobile battlefield targets. Studies conducted on the ERB system showed that the inertially guided weapon could fly not only the standoff mission but also a return-to-target mission against the mobile battlefield targets whose locations are not known accurately enough to use a standoff delivery. The ERB program evolved from these initial investigations into an exploratory program to develop the hardware and demonstrate the technology required to fly standoff and return-to-target trajectories. The application of this technology in the form of field retrofit kits to the B61 bomb is called TIGER II.

NONE

1980-12-31T23:59:59.000Z

267

Tissue-Specific Gene Delivery via Nanoparticle Coating  

E-Print Network [OSTI]

The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant ...

Harris, Todd J.

268

A Fast Delivery Protocol for Total Order Broadcasting  

SciTech Connect (OSTI)

The conclusions of this report are: (1) Fast delivery protocol reduces the latency of message ordering for idle systems and keep comparable performances with communication history algorithms for busy systems; (2) The protocol optimizes the total ordering process by waiting for messages only from a subset of the machines in the group; and (3) The fast acknowledgment aggressively acknowledges total order messages to reduce the latency for idle system, and it is smart enough to hold the acknowledgments when the network communication is heavy.

Ou, Li [Tennessee Technological University; He, X. [Tennessee Technological University; Engelmann, Christian [ORNL; Scott, Stephen L [ORNL

2007-01-01T23:59:59.000Z

269

Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Permeability and Integrity of Hydrogen Delivery Pipelines Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines Project Objectives: To gain basic understanding of...

270

Career Opportunities with the Office of Electricity Delivery...  

Broader source: Energy.gov (indexed) [DOE]

Career Opportunities with the Office of Electricity Delivery & Energy Reliability (OE) Career Opportunities with the Office of Electricity Delivery & Energy Reliability (OE) Career...

271

2012 Annual Planning Summary for Electricity Delivery and Energy...  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery and Energy Reliability 2012 Annual Planning Summary for Electricity Delivery and Energy Reliability The ongoing and projected Environmental Assessments and...

272

2013 Annual Planning Summary for the Office of Electricity Delivery...  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery and Energy Reliability 2013 Annual Planning Summary for the Office of Electricity Delivery and Energy Reliability The ongoing and projected Environmental...

273

Vacancy Announcements Posted for Hydrogen Production and Delivery...  

Broader source: Energy.gov (indexed) [DOE]

Vacancy Announcements Posted for Hydrogen Production and Delivery Program Vacancy Announcements Posted for Hydrogen Production and Delivery Program October 3, 2014 - 10:49am...

274

Special Delivery for Sustainability: Clean Cities Supports UPS...  

Broader source: Energy.gov (indexed) [DOE]

Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding Natural Gas Operations Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding...

275

accurate sobp delivery: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Painter, Kevin 19 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

276

antiretroviral treatment delivery: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

12;Hydrogen Delivery Options Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas novel pigs to...

277

avtip delivery order: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Painter, Kevin 25 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

278

adaptive aerosol delivery: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Painter, Kevin 45 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

279

aerial dispersant delivery: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Painter, Kevin 72 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

280

adenoviral gene delivery: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

12;Hydrogen Delivery Options Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas novel pigs to...

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

arthritis boron delivery: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Painter, Kevin 58 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

282

Office of Electricity Delivery and Energy Reliability Recovery...  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery and Energy Reliability Recovery Program Plan Office of Electricity Delivery and Energy Reliability Recovery Program Plan Microsoft Word - OE PSRP June 5 2009...

283

Secretary of Energy Announces New Office of Electricity Delivery...  

Office of Environmental Management (EM)

New Office of Electricity Delivery & Energy Reliability Secretary of Energy Announces New Office of Electricity Delivery & Energy Reliability June 9, 2005 - 1:45pm Addthis...

284

Office of Electricity Delivery And Energy Reliability To Hold...  

Broader source: Energy.gov (indexed) [DOE]

Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy...

285

The Office of Electricity Delivery and Energy Reliability is...  

Broader source: Energy.gov (indexed) [DOE]

The Office of Electricity Delivery and Energy Reliability is Closely Monitoring Hurricane Irene (2011) The Office of Electricity Delivery and Energy Reliability is Closely...

286

Office of Electricity Delivery & Energy Reliability FY 2012 Budget...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation...

287

Office of Electricity Delivery and Energy Reliability Cyber Security...  

Broader source: Energy.gov (indexed) [DOE]

Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections On...

288

Energy-Efficient Melting and Direct Delivery of High Quality...  

Broader source: Energy.gov (indexed) [DOE]

Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum itmdelivery.pdf More...

289

Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM...  

Broader source: Energy.gov (indexed) [DOE]

Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results This presentation by...

290

April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure...  

Energy Savers [EERE]

April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure Initiative FOA April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure Initiative FOA March 23,...

291

Status and EAC Recommendations for Electricity Delivery Workforce...  

Energy Savers [EERE]

Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) This memo,...

292

Hydrogen Delivery R&D Activities | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

R&D Activities Hydrogen Delivery R&D Activities Hydrogen delivery technology may encompass several options over the short and long terms. The transportation and distribution...

293

H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and...

294

Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery...  

Broader source: Energy.gov (indexed) [DOE]

Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop Targets, barriers and...

295

Essays on health care delivery and financing  

E-Print Network [OSTI]

This thesis contains essays on health care delivery and financing. Chapter 1 studies the effect of organizational structure on physician behavior. I investigate this by studying emergency department (ED) physicians who ...

Chan, David C. (David Cchimin)

2013-01-01T23:59:59.000Z

296

Coordinated part delivery using distributed planning  

E-Print Network [OSTI]

In this thesis, we develop a distributed mobile robot platform to deliver parts around a model construction site. The platform's robots, specialized into delivery robots and assembly robots, use a distributed coverage ...

Bolger, Adrienne (Adrienne M.)

2010-01-01T23:59:59.000Z

297

Delivery and Receipt | Department of Energy  

Energy Savers [EERE]

(301) 903-3790; Phone: (301) 903-6492 Delivery Addresses for the Loading Docks U.S. Department of Energy Forrestal Building 1000 Independence Avenue, S.W. Washington, D.C. 20585...

298

Research Plan: Foam Delivery of Remedial Amendments to Deep Vadose Zone for Metals and Radionuclides Remediation  

SciTech Connect (OSTI)

Research proposals were submitted to the Scientific and Technical Basis for In Situ Treatment of Metals and Radionuclides Technical Working Group under the US Department of Energy (DOE) Environmental Management Office (specifically, EM-22). After a peer review and selection process, the proposal, “Foam Delivery of Remedial Amendments to Deep Vadose Zone for Metals and Radionuclides Remediation,” submitted by Pacific Northwest National Laboratory (PNNL) was selected for support by the program. A research plan was requested for this EM funded project. The overall objective of this project is to develop foam delivery technology for the distribution of remedial amendments to deep vadose zone sediments for in situ immobilization of metal and radionuclide contaminants. The focus of this research in FY 2009 is on the physical aspects of the foam delivery approach. Specific objectives are to 1) study the foam quality (i.e. the gas volume fraction in foam) influence on injection pressure, 2) study the sediment air permeability influence on injection pressure, 3) investigate liquid uptake in sediment and determine whether a water front will be formed during foam delivery, 4) test amendment distance (and mass) delivery by foam from the injection point, 5) study the enhanced sweeping over heterogeneous systems (i.e., low K zones) by foam delivery relative to water-based delivery under vadose zone conditions, and 6) numerically simulate foam delivery processes in the vadose zone. Laboratory scale experiments will be conducted at PNNL to study a range of basic physical aspects of the foam propagation in sediments, including foam quality and sediment permeability influence on injection pressure, liquid uptake, and foam sweeping across heterogeneous systems. This study will be augmented with separate studies to be conducted at MSE Technology Applications, Inc. (MSE) to evaluate foam transport and amendment delivery at the intermediate-scale. The results of intermediate-scale tests will be used to bridge the gap between the small-scale foam transport studies and the field-scale demonstration. Numerical simulation studies on foam delivery under vadose conditions will be performed to simulate observed foam transport behavior under vadose zone conditions and predict the foam delivery performance at field-scale.

Zhong, Lirong; Hart, Andrea T.; Szecsody, James E.; Zhang, Z. F.; Freedman, Vicky L.; Ankeny, Mark; Hull, Laurence; Oostrom, Martinus; Freshley, Mark D.; Wellman, Dawn M.

2009-01-16T23:59:59.000Z

299

Assessment of the Electrical Power Requirements for Continued Safe Storage and Waste Feed Delivery Phase 1  

SciTech Connect (OSTI)

This study evaluated the ability of the electrical distribution system to support safe storage as well as the first phase of the Waste Feed Delivery. Several recommendations are made to improve the electrical system. The ability to assure adequate Waste Feed Delivery (WFD) to the Privatization Contractor's vitrification facility is a key element in the overall Hanford cleanup schedule. An important aspect of this WFD is the availability of sufficient and appropriate electrical power in the single- and double-shell tank farms. The methodology for performing this review and the results are described.

MAY, T.H.

2000-04-07T23:59:59.000Z

300

THE HANFORD WASTE FEED DELIVERY OPERATIONS RESEARCH MODEL  

SciTech Connect (OSTI)

Washington River Protection Solutions (WRPS), the Hanford tank farm contractor, is tasked with the long term planning of the cleanup mission. Cleanup plans do not explicitly reflect the mission effects associated with tank farm operating equipment failures. EnergySolutions, a subcontractor to WRPS has developed, in conjunction with WRPS tank farms staff, an Operations Research (OR) model to assess and identify areas to improve the performance of the Waste Feed Delivery Systems. This paper provides an example of how OR modeling can be used to help identify and mitigate operational risks at the Hanford tank farms.

BERRY J; GALLAHER BN

2011-01-13T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Space Data Systems (ISR-3)  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3 Space Data Systems Data collection and processing, information exploitation and delivery Contacts Group Leader Michael Cai Email Staff Operations Manager Nancy Graves Email...

302

DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project...  

Broader source: Energy.gov (indexed) [DOE]

Delivery High-Pressure Tanks and Analysis Project Review Meeting DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting On February 8-9, 2005, the Department...

303

Tracking Mobile Units for Dependable Message Delivery  

E-Print Network [OSTI]

Tracking Mobile Units for Dependable Message Delivery Amy L. Murphy, Member, IEEE Computer Society at their disposal at any time, mobile computing is developing as an important research area. One of the fundamental problems in mobility is maintaining connectivity through message passing as the user moves through

Zhou, Yuanyuan

304

Materials Solutions for Hydrogen Delivery in Pipelines  

E-Print Network [OSTI]

Materials Solutions for Hydrogen Delivery in Pipelines Dr. Subodh K. Das Secat, Inc. September of new pipeline infrastructure Develop barrier coatings for minimizing hydrogen permeation in pipelines;NACE Hydrogen Induced Cracking (HIC) Test Evaluates resistance of pipeline and pressure vessel

305

Improvements to Hydrogen Delivery Scenario Analysis  

E-Print Network [OSTI]

Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results May 8, 2007 Amgad and storage are at or adjacent to Liquid Hydrogen (LH) TruckH2 Production 100 or 1500 kg/d Compressed H2 (CH) Truck H2 Production 3 or 7 kpsi 100 or 1500 kg/d H2 Production Gaseous H2 Pipeline 100 or 1500 kg

306

Global delivery of IT services : looking beyond the global delivery model  

E-Print Network [OSTI]

The objective of this thesis is to analyze the factors that create competitive advantage through global delivery of IT services. Research on this thesis consists of a review of IT services markets and globally distributed ...

Cherian, Binoy

2007-01-01T23:59:59.000Z

307

FINAL AGENDA DOE Hydrogen Delivery Analysis and High Pressure Tanks  

E-Print Network [OSTI]

, National Renewable Energy Laboratory 3:00 BREAK 3:15 H2A Delivery Scenario Model and Analyses Jerry:15 Ethanol Delivery Cost and Distributed Ethanol Reforming Matt Ringer, National Renewable Energy Laboratory and breakfast 8:30 Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs, Transition and Long

308

Review Guidance for the TWRS FSAR amendment for Waste Retrieval and waste feed delivery  

SciTech Connect (OSTI)

This review guidance (Guide) was developed for Office of River Protection (ORP) reviewers to use in reviewing the amendment to the Tank Waste Remediation System (TWRS) Final Safety Analysis Report (FSAR) covering waste retrieval and waste feed delivery. Waste retrieval and waste feed delivery are necessary to supply nuclear waste from TWRS storage tanks to the TWRS Privatization (TWRS-P) Contractor's vitrification facility and to receive intermediate waste from the vitrification facility back into the TWRS tank farms for interim storage. An amendment to the approved TWRS FSAR (HNF-SD-WM-SAR-067, Rev. 0) is necessary to change the authorization basis to accommodate waste retrieval and waste feed delivery. The ORP'S safety responsibility in reviewing the FSAR amendment is to determine that reasonable assurance exists that waste retrieval and waste feed delivery operations can be accomplished with adequate safety for the workers, the public, and the environment. To carry out this responsibility, the ORP will evaluate the Contractor's amendment to the TWRS FSAR for waste retrieval and waste feed delivery to determine whether the submittal provides adequate safety and complies with applicable regulatory requirements.

GRIFFITH, R.W.

1999-10-01T23:59:59.000Z

309

Geek-Up[12.10.2010]: A New Planet in Another Solar System, Fast-Tracked Drug Treatments and Better Batteries  

Broader source: Energy.gov [DOE]

Using high-contrast, near infrared adaptive optics on the Keck II telescope in Hawaii, LLNL astronomers have identified a fourth planet that is part of a new planetary system discovered in 2008.

310

Cryogenics for superconductors: Refrigeration, delivery, and preservation of the cold  

SciTech Connect (OSTI)

Applications in superconductivity have become widespread, enabled by advancements in cryogenic engineering. In this paper, the history of cryogenic refrigeration, its delivery, its preservation and the important scientific and engineering advancements in these areas in the last 100 years will be reviewed, beginning with small laboratory dewars to very large scale systems. The key technological advancements in these areas that enabled the development of superconducting applications at temperatures from 4 to 77 K are identified. Included are advancements in the components used up to the present state-of-the-art in refrigeration systems design. Viewpoints as both an equipment supplier and the end-user with regard to the equipment design and operations will be presented. Some of the present and future challenges in these areas will be outlined. Most of the materials in this paper are a collection of the historical materials applicable to these areas of interest.

Venkatarao Ganni, James Fesmire

2012-06-01T23:59:59.000Z

311

A study of IMRT planning parameters on planning efficiency, delivery efficiency, and plan quality  

SciTech Connect (OSTI)

Purpose: To improve planning and delivery efficiency of head and neck IMRT without compromising planning quality through the evaluation of inverse planning parameters.Methods: Eleven head and neck patients with pre-existing IMRT treatment plans were selected for this retrospective study. The Pinnacle treatment planning system (TPS) was used to compute new treatment plans for each patient by varying the individual or the combined parameters of dose/fluence grid resolution, minimum MU per segment, and minimum segment area. Forty-five plans per patient were generated with the following variations: 4 dose/fluence grid resolution plans, 12 minimum segment area plans, 9 minimum MU plans, and 20 combined minimum segment area/minimum MU plans. Each plan was evaluated and compared to others based on dose volume histograms (DVHs) (i.e., plan quality), planning time, and delivery time. To evaluate delivery efficiency, a model was developed that estimated the delivery time of a treatment plan, and validated through measurements on an Elekta Synergy linear accelerator. Results: The uncertainty (i.e., variation) of the dose-volume index due to dose calculation grid variation was as high as 8.2% (5.5 Gy in absolute dose) for planning target volumes (PTVs) and 13.3% (2.1 Gy in absolute dose) for planning at risk volumes (PRVs). Comparison results of dose distributions indicated that smaller volumes were more susceptible to uncertainties. The grid resolution of a 4 mm dose grid with a 2 mm fluence grid was recommended, since it can reduce the final dose calculation time by 63% compared to the accepted standard (2 mm dose grid with a 2 mm fluence grid resolution) while maintaining a similar level of dose-volume index variation. Threshold values that maintained adequate plan quality (DVH results of the PTVs and PRVs remained satisfied for their dose objectives) were 5 cm{sup 2} for minimum segment area and 5 MU for minimum MU. As the minimum MU parameter was increased, the number of segments and delivery time were decreased. Increasing the minimum segment area parameter decreased the plan MU, but had less of an effect on the number of segments and delivery time. Our delivery time model predicted delivery time to within 1.8%. Conclusions: Increasing the dose grid while maintaining a small fluence grid allows for improved planning efficiency without compromising plan quality. Delivery efficiency can be improved by increasing the minimum MU, but not the minimum segment area. However, increasing the respective minimum MU and/or the minimum segment area to any value greater than 5 MU and 5 cm{sup 2} is not recommended because it degrades plan quality.

Mittauer, Kathryn [Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, Florida 32603 and J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 (United States); Lu Bo; Yan Guanghua; Kahler, Darren; Amdur, Robert; Liu Chihray [Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, Florida 32603 (United States); Gopal, Arun [Department of Radiation Oncology, New York-Presbyterian Hospital, Columbia University, New York, New York 10032 (United States)

2013-06-15T23:59:59.000Z

312

Monte Carlo calculation of helical tomotherapy dose delivery  

SciTech Connect (OSTI)

Helical tomotherapy delivers intensity modulated radiation therapy using a binary multileaf collimator (MLC) to modulate a fan beam of radiation. This delivery occurs while the linac gantry and treatment couch are both in constant motion, so the beam describes, from a patient/phantom perspective, a spiral or helix of dose. The planning system models this continuous delivery as a large number (51) of discrete gantry positions per rotation, and given the small jaw/fan width setting typically used (1 or 2.5 cm) and the number of overlapping rotations used to cover the target (pitch often <0.5), the treatment planning system (TPS) potentially employs a very large number of static beam directions and leaf opening configurations to model the modulated fields. All dose calculations performed by the system employ a convolution/superposition model. In this work the authors perform a full Monte Carlo (MC) dose calculation of tomotherapy deliveries to phantom computed tomography (CT) data sets to verify the TPS calculations. All MC calculations are performed with the EGSnrc-based MC simulation codes, BEAMnrc and DOSXYZnrc. Simulations are performed by taking the sinogram (leaf opening versus time) of the treatment plan and decomposing it into 51 different projections per rotation, as does the TPS, each of which is segmented further into multiple MLC opening configurations, each with different weights that correspond to leaf opening times. Then the projection is simulated by the summing of all of the opening configurations, and the overall rotational treatment is simulated by the summing of all of the projection simulations. Commissioning of the source model was verified by comparing measured and simulated values for the percent depth dose and beam profiles shapes for various jaw settings. The accuracy of the MLC leaf width and tongue and groove spacing were verified by comparing measured and simulated values for the MLC leakage and a picket fence pattern. The validated source and MLC configuration were then used to simulate a complex modulated delivery from fixed gantry angle. Further, a preliminary rotational treatment plan to a delivery quality assurance phantom (the 'cheese' phantom) CT data set was simulated. Simulations were compared with measured results taken with an A1SL ionization chamber or EDR2 film measurements in a water tank or in a solid water phantom, respectively. The source and MLC MC simulations agree with the film measurements, with an acceptable number of pixels passing the 2%/1 mm gamma criterion. 99.8% of voxels of the MC calculation in the planning target volume (PTV) of the preliminary plan passed the 2%/2 mm gamma value test. 87.0% and 66.2% of the voxels in two organs at risk (OARs) passed the 2%/2 mm tests. For a 3%/3 mm criterion, the PTV and OARs show 100%, 93.2%, and 86.6% agreement, respectively. All voxels passed the gamma value test with a criterion of 5%/3 mm. The TomoTherapy TPS showed comparable results.

Zhao Yingli; Mackenzie, M.; Kirkby, C.; Fallone, B. G. [Department of Medical Physics, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada) and Department of Physics, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada); Department of Medical Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada); Department of Medical Physics, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada and Department of Physics, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada)

2008-08-15T23:59:59.000Z

313

Fabrication of Metal/Oxide Nanostructures by Anodization Processes for Biosensor, Drug Delivery and Supercapacitor Applications  

E-Print Network [OSTI]

applications of micro/nano structures; (2) novel processes to innovate anodic aluminum oxide nanotube template; (3) the supercapacitor applications of anodic titanium oxide. First, the extremely high surface area AAO coated microneedle and microneedle array...

Chen, Po-Chun

2014-01-13T23:59:59.000Z

314

Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites  

E-Print Network [OSTI]

Staphylococcus aureus (MRSA) growth in chronic otitis mediaco-glycolide) disc: Inhibition of MRSA(methicillin resistantco-glycolide) disc: Inhibition of MRSA(methicillin resistant

Perelman, Loren Avery

2008-01-01T23:59:59.000Z

315

Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites  

E-Print Network [OSTI]

Sailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructureMichael J. Engineering the chemistry and nanostructure of

Perelman, Loren Avery

2008-01-01T23:59:59.000Z

316

Chemically modified and nanostructured porous silicon as a drug delivery material and device  

E-Print Network [OSTI]

Sailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructure

Anglin, Emily Jessica

2007-01-01T23:59:59.000Z

317

Design, synthesis, and evaluation of dendrimers based on melamine as drug delivery vehicles  

E-Print Network [OSTI]

.1 Divergent and convergent synthetic routes to dendrimers .......................... 2 1.2 Architecture of dendrimers: (a) PPI; (b) PAMAM; (c) polyester; (d) triazine-based dendrimer... 3.9 Post-PET biodistribution data of a 124 I-labeled dendrimer (~17 kDa) in nude mice with PC-3-Luc xenografts at 48 h post-injection .................. 41 4.1 1 H NMR assignment and integration of 2 in the expanded region 4.8 to 8.2 ppm...

Lim, Jong Doo

2009-05-15T23:59:59.000Z

318

Refactored M13 Bacteriophage as a Platform for Tumor Cell Imaging and Drug Delivery  

E-Print Network [OSTI]

M13 bacteriophage is a well-characterized platform for peptide display. The utility of the M13 display platform is derived from the ability to encode phage protein fusions with display peptides at the genomic level. However, ...

Ghosh, Debadyuti

319

Functionalized Zirconium Phosphate Nano Platelets - From Surface Design to Drug Delivery  

E-Print Network [OSTI]

spectrometry (SIMS) technique are Au_(400)^(4+) and C_(60)^(+/2+). The ionized ejecta from each impact are recorded individually which identifies ions emitted from a surface volume of ~10 nm in diameter and 5-10 nm in depth. The mode of analyzing ejecta...

Mukherjee, Atashi

2014-05-30T23:59:59.000Z

320

Theoretical and experimental investigations of passive and ultrasound-enhanced transdermal drug delivery  

E-Print Network [OSTI]

In the initial investigation of this thesis, Fick's second law of diffusion was modified to describe both the transient, and the steady-state, transdermal transport of hydrophilic permeants through unbranched, aqueous pore ...

Kushner, Joseph, IV

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Water-soluble carbon nanotube compositions for drug delivery and medicinal applications  

DOE Patents [OSTI]

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

Tour, James M.; Lucente-Schultz, Rebecca; Leonard, Ashley; Kosynkin, Dmitry V.; Price, Brandi Katherine; Hudson, Jared L.; Conyers, Jr., Jodie L.; Moore, Valerie C.; Casscells, S. Ward; Myers, Jeffrey N.; Milas, Zvonimir L.; Mason, Kathy A.; Milas, Luka

2014-07-22T23:59:59.000Z

322

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network [OSTI]

Synthetic Nano-Low Density Lipoprotein as Targeted Drugmicroemulsion; peptide; nano-low density lipoproteintherapeutic agents. A synthetic nano-LDL (nLDL) particle was

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

323

Development of lymphatic drug delivery platforms for the treatment of carcinomas  

E-Print Network [OSTI]

……………………………………….234 2. Release of nitric oxide from JS-K, JS-K analogues and carrier-based prodrugs…….....236 xi 3. Dosing schedule and results of caspase-3, resazurin and trypan blue assays in MDA-1986 cells…………………………………………………………………..….....238 4. Results.... In the following chapters, the development, characterization, in vitro and in vivo evaluation, of three polymer-based chemotherapeutic conjugates will be described. 2. Localized chemotherapy The most common types of cancer therapies include surgery, radiation...

Cai, Shuang

2011-05-31T23:59:59.000Z

324

Synthesis of novel polymeric nanoparticles for hydrophobic and hydrophilic drug delivery  

E-Print Network [OSTI]

at 30?C. The mobile phase water to acetonitrile ratio 50:70 water to acetonitrile was kept constant during thestandards were in the same acetonitrile percent solution.

Sartor, Marta

2010-01-01T23:59:59.000Z

325

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network [OSTI]

D. F. , Kahl, S. B. , Bjornstad, K. A. , Bauer, W. F. ,L. , Blakely, E. A. , Bjornstad, K. A. , Deen, D. F. ,Blakely 2 , Kathleen A. Bjornstad 2 , Xiao Shu 3 ,Thomas F.

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

326

pH-sensitive core-shell nanoparticles for intracellular drug delivery  

E-Print Network [OSTI]

Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis ...

Hu, Yuhua, Ph. D. Massachusetts Institute of Technology

2008-01-01T23:59:59.000Z

327

Nano compartments may aid drug delivery, catalyst design > Archived News  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the Contributions andData andFleet TestAccounts andThe Role ofStorage - Energy

328

E-Print Network 3.0 - adhesive drug delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

calls for the design of the ... Source: Peppas, Nicholas A. - Departments of Biomedical Engineering & Chemical Engineering, University of Texas at Austin Collection:...

329

AVTA: Hybrid-Electric Delivery Vehicles  

Broader source: Energy.gov [DOE]

The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a wide range of advanced vehicles and technologies on dynamometers, closed test tracks, and on-the-road. These results provide benchmark data that researchers can use to develop technology models and guide future research and development. The following set of reports describes data collected from testing on FedEx Express and UPS hybrid-electric delivery trucks. This research was conducted by the National Renewable Energy Laboratory (NREL).

330

Delivery Tech Team | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeat Pump Models | Department1 Prepared1217 Release Notes Dekker PMISWashmgton,Delivery

331

Statistical quality control for volumetric modulated arc therapy (VMAT) delivery using machine log data  

E-Print Network [OSTI]

The aim of this study is to set up statistical quality control for monitoring of volumetric modulated arc therapy (VMAT) delivery error using machine log data. Eclipse and Clinac iX linac with the RapidArc system (Varian Medical Systems, Palo Alto, USA) is used for delivery of the VMAT plan. During the delivery of the RapidArc fields, the machine determines the delivered motor units (MUs) and gantry angle position accuracy and the standard deviations of MU (sigma_MU; dosimetric error) and gantry angle (sigma_GA; geometric error) are displayed on the console monitor after completion of the RapidArc delivery. In the present study, first, the log data was analyzed to confirm its validity and usability; then, statistical process control (SPC) was applied to monitor the sigma_MU and sigma_GA in a timely manner for all RapidArc fields: a total of 195 arc fields for 99 patients. The sigma_MU and sigma_GA were determined twice for all fields, that is, first during the patient-specific plan QA and then again during th...

Cheong, Kwang-Ho; Kang, Sei-Kwon; Yoon, Jai-Woong; Park, Soah; Hwang, Taejin; Kim, Haeyoung; Kim, Kyoung Ju; Han, Tae Jin; Bae, Hoonsik

2015-01-01T23:59:59.000Z

332

Superconductivity for Electric Systems: 2008 Annual Peer Review...  

Broader source: Energy.gov (indexed) [DOE]

for Electric Systems: 2008 Annual Peer Review Final Report Superconductivity for Electric Systems: 2008 Annual Peer Review Final Report The Office of Electricity Delivery and...

333

Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapy  

SciTech Connect (OSTI)

Purpose: To describe biological-based optimization and Monte Carlo (MC) dose calculation-based treatment planning for volumetric modulated arc therapy (VMAT) delivery of stereotactic body radiation therapy (SBRT) in lung, liver, and prostate patients. Methods: Optimization strategies and VMAT planning parameters using a biological-based optimization MC planning system were analyzed for 24 SBRT patients. Patients received a median dose of 45 Gy [range, 34-54 Gy] for lung tumors in 1-5 fxs and a median dose of 52 Gy [range, 48-60 Gy] for liver tumors in 3-6 fxs. Prostate patients received a fractional dose of 10 Gy in 5 fxs. Biological-cost functions were used for plan optimization, and its dosimetric quality was evaluated using the conformity index (CI), the conformation number (CN), the ratio of the volume receiving 50% of the prescription dose over the planning target volume (Rx/PTV50). The quality and efficiency of the delivery were assessed according to measured quality assurance (QA) passing rates and delivery times. For each disease site, one patient was replanned using physical cost function and compared to the corresponding biological plan. Results: Median CI, CN, and Rx/PTV50 for all 24 patients were 1.13 (1.02-1.28), 0.79 (0.70-0.88), and 5.3 (3.1-10.8), respectively. The median delivery rate for all patients was 410 MU/min with a maximum possible rate of 480 MU/min (85%). Median QA passing rate was 96.7%, and it did not significantly vary with the tumor site. Conclusions: VMAT delivery of SBRT plans optimized using biological-motivated cost-functions result in highly conformal dose distributions. Plans offer shorter treatment-time benefits and provide efficient dose delivery without compromising the plan conformity for tumors in the prostate, lung, and liver, thereby improving patient comfort and clinical throughput. The short delivery times minimize the risk of patient setup and intrafraction motion errors often associated with long SBRT treatment delivery times.

Diot, Quentin; Kavanagh, Brian; Timmerman, Robert; Miften, Moyed [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States); Department of Radiation Oncology, University of Texas Southwestern Medical School, Dallas, Texas 75390 (United States); Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States)

2012-01-15T23:59:59.000Z

334

Steam distribution and energy delivery optimization using wireless sensors  

SciTech Connect (OSTI)

The Extreme Measurement Communications Center at Oak Ridge National Laboratory (ORNL) explores the deployment of a wireless sensor system with a real-time measurement-based energy efficiency optimization framework in the ORNL campus. With particular focus on the 12-mile long steam distribution network in our campus, we propose an integrated system-level approach to optimize the energy delivery within the steam distribution system. We address the goal of achieving significant energy-saving in steam lines by monitoring and acting on leaking steam valves/traps. Our approach leverages an integrated wireless sensor and real-time monitoring capabilities. We make assessments on the real-time status of the distribution system by mounting acoustic sensors on the steam pipes/traps/valves and observe the state measurements of these sensors. Our assessments are based on analysis of the wireless sensor measurements. We describe Fourier-spectrum based algorithms that interpret acoustic vibration sensor data to characterize flows and classify the steam system status. We are able to present the sensor readings, steam flow, steam trap status and the assessed alerts as an interactive overlay within a web-based Google Earth geographic platform that enables decision makers to take remedial action. We believe our demonstration serves as an instantiation of a platform that extends implementation to include newer modalities to manage water flow, sewage and energy consumption.

Olama, Mohammed M [ORNL; Allgood, Glenn O [ORNL; Kuruganti, Phani Teja [ORNL; Sukumar, Sreenivas R [ORNL; Djouadi, Seddik M [ORNL; Lake, Joe E [ORNL

2011-01-01T23:59:59.000Z

335

TIMELY DELIVERY OF LASER INERTIAL FUSION ENERGY (LIFE)  

SciTech Connect (OSTI)

The National Ignition Facility (NIF), the world's largest and most energetic laser system, is now operational at Lawrence Livermore National Laboratory. A key goal of the NIF is to demonstrate fusion ignition for the first time in the laboratory. Its flexibility allows multiple target designs (both indirect and direct drive) to be fielded, offering substantial scope for optimization of a robust target design. In this paper we discuss an approach to generating gigawatt levels of electrical power from a laser-driven source of fusion neutrons based on these demonstration experiments. This 'LIFE' concept enables rapid time-to-market for a commercial power plant, assuming success with ignition and a technology demonstration program that links directly to a facility design and construction project. The LIFE design makes use of recent advances in diode-pumped, solid-state laser technology. It adopts the paradigm of Line Replaceable Units utilized on the NIF to provide high levels of availability and maintainability and mitigate the need for advanced materials development. A demonstration LIFE plant based on these design principles is described, along with the areas of technology development required prior to plant construction. A goal-oriented, evidence-based approach has been proposed to allow LIFE power plant rollout on a time scale that meets policy imperatives and is consistent with utility planning horizons. The system-level delivery builds from our prior national investment over many decades and makes full use of the distributed capability in laser technology, the ubiquity of semiconductor diodes, high volume manufacturing markets, and U.S. capability in fusion science and nuclear engineering. The LIFE approach is based on the ignition evidence emerging from NIF and adopts a line-replaceable unit approach to ensure high plant availability and to allow evolution from available technologies and materials. Utilization of a proven physics platform for the ignition scheme is an essential component of an acceptably low-risk solution. The degree of coupling seen on NIF between driver and target performance mandates that little deviation be adopted from the NIF geometry and beamline characteristics. Similarly, the strong coupling between subsystems in an operational power plant mandates that a self-consistent solution be established via an integrated facility delivery project. The benefits of separability of the subsystems within an IFE plant (driver, chamber, targets, etc.) emerge in the operational phase of a power plant rather than in its developmental phase. An optimized roadmap for IFE delivery needs to account for this to avoid nugatory effort and inconsistent solutions. For LIFE, a system design has been established that could lead to an operating power plant by the mid-2020s, drawing from an integrated subsystem development program to demonstrate the required technology readiness on a time scale compatible with the construction plan. Much technical development work still remains, as does alignment of key stakeholder groups to this newly emerging development option. If the required timeline is to be met, then preparation of a viable program is required alongside the demonstration of ignition on NIF. This will enable timely analysis of the technical and economic case and establishment of the appropriate delivery partnership.

Dunne, A M

2010-11-30T23:59:59.000Z

336

Delivery and Receipt | Department of Energy  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energy UsageAUDITVehicles » AlternativeUp HomeHorseDOE DirectivesDepartment of2Delivery and

337

,"New Mexico Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

,,"(202) 586-8800",,,"3292015 10:05:26 PM" "Back to Contents","Data 1: New Mexico Natural Gas Deliveries to Electric Power Consumers (MMcf)"...

338

2012 Director's Science Delivery Award | ornl.gov  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

SHARE 2012 Director's Science Delivery Award June 24, 2013 CSMD Researcher Forrest Hoffman (along with ORNL researchers Jitendra Kumar and Richard Mills), is on the team that...

339

PHEV Parcel Delivery Truck Model - Development and Preliminary Results (Presentation)  

SciTech Connect (OSTI)

Describes results of a study to determine the impact of drive cycles on the energy- and cost-effectiveness of plug-in hybrid electric delivery vans.

Barnitt, R

2009-10-28T23:59:59.000Z

340

Vectren Energy Delivery of Indiana (Gas)- Residential Energy Efficiency Rebates  

Broader source: Energy.gov [DOE]

Vectren Energy Delivery offers its residential natural gas customers in Indiana rebates for the installation of certain high efficiency natural gas appliances and insulation measures. Rebates are...

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Vectren Energy Delivery of Ohio (Gas)- Residential Energy Efficiency Rebates  

Broader source: Energy.gov [DOE]

Vectren Energy Delivery offers residential natural gas customers in Ohio rebates for the installation of certain high efficiency natural gas appliances and building insulation. Rebates are...

342

Determining the lowest-cost hydrogen delivery mode  

E-Print Network [OSTI]

costs to estimate hydrogen pipeline costs. Davis, CA: ITS-hydrogen. The cost of hydrogen pipeline delivery de- pendshydrogen trucks, and hydrogen pipelines, were devel- oped

Yang, Christopher; Ogden, Joan M

2007-01-01T23:59:59.000Z

343

Office of Electricity Delivery and Energy Reliability, OE-20  

Broader source: Energy.gov (indexed) [DOE]

9 January, 2012 Office of Electricity Delivery and Energy Reliability, OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585 Greetings: The Wyoming...

344

Vectren Energy Delivery of Indiana (Gas)- Commercial Energy Efficiency Rebates  

Broader source: Energy.gov [DOE]

Vectren Energy Delivery offers commercial natural gas customers in Indiana rebates for the installation of certain types of efficient natural gas equipment. Prescriptive equipment rebates are...

345

Office of Electricity Delivery and Energy Reliability | Department...  

Broader source: Energy.gov (indexed) [DOE]

& Internships Funding Opportunities Information Center Contact Us Energy.gov Office of Electricity Delivery & Energy Reliability 1000 Independence Avenue, SW Washington, DC...

346

Vectren Energy Delivery of Ohio (Gas)- Commercial Energy Efficiency Rebates  

Broader source: Energy.gov [DOE]

Vectren Energy Delivery offers commercial natural gas customers in Ohio rebates for the installation of certain types of efficient natural gas equipment. Prescriptive equipment rebates are...

347

H2A Delivery Components Model and Analysis  

Broader source: Energy.gov (indexed) [DOE]

Hydrogen Delivery Components Model Matt Ringer National Renewable Energy Laboratory February 8, 2005 Other Team Members: Mark Paster: DOE Marianne Mintz, Jerry Gillette, Jay Burke:...

348

H2A Delivery Scenario Model and Analyses  

Broader source: Energy.gov (indexed) [DOE]

Marianne Mintz and Jerry Gillette DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting February 8, 2005 2 Pioneering Science and Technology Office...

349

Liquid Hydrogen Production and Delivery from a Dedicated Wind...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

a Dedicated Wind Power Plant Liquid Hydrogen Production and Delivery from a Dedicated Wind Power Plant This May 2012 study assesses the costs and potential for remote renewable...

350

Hydrogen Delivery InfrastructureHydrogen Delivery Infrastructure Option AnalysisOption Analysis  

E-Print Network [OSTI]

Converting NG/oil pipelines for GH delivery Option 3 Blending GH into NG pipelines Option 4* GH tube trailers Option 5* LH tank trucks Option 6 Use of novel H2 carriers (alanate; chemical hydride; liquid hydrocarbon as CA) -- NG distribution lines: gas companies usually use for Class 3 & 4 No odorants used in current H

351

Eighteen-Month Final Evaluation of UPS Second Generation Diesel Hybrid-Electric Delivery Vans  

SciTech Connect (OSTI)

A parallel hybrid-electric diesel delivery van propulsion system was evaluated at a UPS facility in Minneapolis using on-vehicle data logging, fueling, and maintenance records. Route and drive cycle analysis showed different duty cycles for hybrid vs. conventional delivery vans; routes were switched between the study groups to provide a valid comparison. The hybrids demonstrated greater advantage on the more urban routes; the initial conventional vans' routes had less dense delivery zones. The fuel economy of the hybrids on the original conventional group?s routes was 10.4 mpg vs. 9.2 mpg for the conventional group on those routes a year earlier. The hybrid group's fuel economy on the original hybrid route assignments was 9.4 mpg vs. 7.9 mpg for the conventional group on those routes a year later. There was no statistically significant difference in total maintenance cost per mile or for the vehicle total cost of operation per mile. Propulsion-related maintenance cost per mile was 77% higher for the hybrids, but only 52% more on a cost-per-delivery-day basis. Laboratory dynamometer testing demonstrated 13%-36% hybrid fuel economy improvement, depending on duty cycle, and up to a 45% improvement in ton-mi/gal. NOx emissions increased 21%-49% for the hybrids in laboratory testing.

Lammert, M.; Walkowicz, K.

2012-09-01T23:59:59.000Z

352

Cost comparison of collaborative and IPD-like project delivery methods versus non-collaborative project delivery methods  

E-Print Network [OSTI]

Proceedings of the 20th Conference of the International Group for Lean Construction July 17-22, 2012: San Diego, CA, U.S.A. 781 COST COMPARISON OF COLLABORATIVE AND IPD-LIKE PROJECT DELIVERY METHODS VERSUS COMPETITIVE NON... acceptance of IPD for public projects. KEYWORDS Collaboration, Project Delivery, CM-at-Risk (CMR; CMAR), Competitive Sealed Proposal (CSP), Integrated Project Delivery (IPD), Design-Bid-Build (DBB), Cost Comparison INTRODUCTION One of the most widely...

Kulkarni, Aditi; Rybkowski, Zofia K.; Smith, James

2012-07-17T23:59:59.000Z

353

Patient-specific QA and delivery verification of scanned ion beam at NIRS-HIMAC  

SciTech Connect (OSTI)

Purpose: To evaluate a patient-specific QA program and system for constancy checking of a scanning delivery system developed at the National Institute of Radiological Sciences.Methods: For the patient-specific QA, all the planned beams are recalculated on a water phantom with treatment planning software (TPS). The recalculated dose distributions are compared with the measured distributions using a 2D ionization chamber array at several depths, and evaluated using gamma index analysis with criteria of 3% and 3 mm and a pass rate of 90%. For the constancy check, the authors developed the multiwire proportional chamber (MWPC), which can record the delivered 2D fluence images in a slice-by-slice manner. During irradiation for dosimetric QA with the 2D ionization chamber array and an accordion-type water phantom, the 2D fluence images are recorded using the MWPC in the delivery system. These recorded images are then compared to those taken in the treatment session to check the constancy check. This analysis also employs gamma index analysis using the same criteria as in the patient-specific QA. These patient-specific QA and constancy check evaluations were performed using the data of 122 patients.Results: In the patient-specific QA, the measured dose distributions agreed well with those calculated by the TPS, and the QA criteria were satisfied in all measurements. The additional check of the fluence comparison ensured the constancy of the delivered field during each treatment irradiation.Conclusions: The authors established a patient-specific QA program and additional check of delivery constancy in every treatment session. Fluence comparison is a strong tool for constancy checking of the delivery system.

Furukawa, Takuji; Inaniwa, Taku; Hara, Yousuke; Mizushima, Kota; Shirai, Toshiyuki; Noda, Koji [Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)] [Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)

2013-12-15T23:59:59.000Z

354

Data driven health system  

E-Print Network [OSTI]

Effective use of data is believed to be the key to address systemic inefficiencies in health innovation and delivery, and to significantly enhance value creation for patients and all stakeholders. However, there is no ...

Rosen Ceruolo, Melissa Beth

2013-01-01T23:59:59.000Z

355

Timely Delivery of Laser Inertial Fusion Energy Presentation prepared for  

E-Print Network [OSTI]

plant design · Delivery soon enough to make a difference to global energy imperatives. · Design basedTimely Delivery of Laser Inertial Fusion Energy Presentation prepared for Town Hall meeting must directly address the end-user requirement for commercial power 3 Plant Primary Criteria (partial

356

CIB White Paper on IDDS Integrated Design & Delivery Solutions  

E-Print Network [OSTI]

CIB White Paper on IDDS Integrated Design & Delivery Solutions Publication 328 ISBN 978-90-6363-060-7 #12;CIB White Paper on IDDS Page 1 of 15 CIB White Paper on IDDS Integrated Design & Delivery White Paper on IDDS Page 2 of 15 Table of Contents Introduction and Use of this White Paper

Amor, Robert

357

SciTech Connect: Drug Retention Times  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administrationcontroller systems controllerAdditiveBetatronAerogelDistances fromUsage SystemDrug

358

Systems Theory for Pharmaceutical Drug Discovery  

E-Print Network [OSTI]

3):371–381, 2002. [204] Alan Turing. The chemical basis ofwas the seminal paper by Alan Turing on morphogenesis. The

Aswani, Anil Jayanti

2010-01-01T23:59:59.000Z

359

Joint Meeting on Hydrogen Delivery Modeling and Analysis FreedomCAR and Fuels Partnership Hydrogen Delivery, Storage and  

E-Print Network [OSTI]

. ­ The current capital costs for the hydrogen pipelines in the model are based on 1.1X the price of steel naturalJoint Meeting on Hydrogen Delivery Modeling and Analysis FreedomCAR and Fuels Partnership Hydrogen be prioritized) by mid-2008 H2A Delivery Model: Discussion Items, Comments, and Follow-up Actions 1. Pipeline

360

U.S. Department of Energy Office of Electricity Delivery & Energy...  

Broader source: Energy.gov (indexed) [DOE]

Department of Energy Office of Electricity Delivery & Energy Reliability: Transmission Reliability Program U.S. Department of Energy Office of Electricity Delivery & Energy...

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

anti-hiv sirna delivery: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

12;Hydrogen Delivery Options Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas novel pigs to...

362

aav-mediated intramuscular delivery: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Painter, Kevin 24 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

363

2H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...  

Broader source: Energy.gov (indexed) [DOE]

pipelines for gaseous hydrogen delivery Option 2: Use of existing natural gas or oil pipelines for gaseous hydrogen delivery Option 3: Use of existing natural gas pipelines...

364

Electric Power Delivery Testing Feasibility Study Task 6 Final Report  

SciTech Connect (OSTI)

This Final Report is covers the completion of the Electric Power Delivery Testing Feasibility Study. The objective of this project was to research, engineer, and demonstrate high-power laboratory testing protocols to accurately reproduce the conditions on the electric power grid representing both normal load switching and abnormalities such as short-circuit fault protection. Test circuits, equipment, and techniques were developed and proven at reduced power levels to determine the feasibility of building a large-scale high-power testing laboratory capable of testing equipment and systems at simulated high-power conditions of the U.S. power grid at distribution levels up through 38 kiloVolts (kV) and transmission levels up through 230 kV. The project delivered demonstrated testing techniques, high-voltage test equipment for load testing and synthetic short-circuit testing, and recommended designs for future implementation of a high-power testing laboratory to test equipment and systems, enabling increased reliability of the electric transmission and distribution grid.

Thomas Tobin

2009-07-01T23:59:59.000Z

365

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

- Protecting Intelligent Distributed Power Grids Against Cyber Attacks - Dong Wei, Siemens.pdf CEDS 2010 Peer Review - Protecting PCS Against Lifecycle Attacks Using Trust...

366

Background Paper on E-cigarettes (Electronic Nicotine Delivery Systems)  

E-Print Network [OSTI]

and Health. U.S. EPA. Acrolein [Online]. Available: http://2012) and glycerol forms acrolein, which can cause upperacetealdehyde and acrolein), volatile organic compounds (

Grana, Rachel PhD, MPH; Benowitz, Neal MD; Glantz, Stanton A. PhD

2013-01-01T23:59:59.000Z

367

HYDROGEN PRODUCTION AND DELIVERY INFRASTRUCTURE AS A COMPLEX ADAPTIVE SYSTEM  

SciTech Connect (OSTI)

An agent-based model of the transition to a hydrogen transportation economy explores influences on adoption of hydrogen vehicles and fueling infrastructure. Attention is given to whether significant penetration occurs and, if so, to the length of time required for it to occur. Estimates are provided of sensitivity to numerical values of model parameters and to effects of alternative market and policy scenarios. The model is applied to the Los Angeles metropolitan area In the benchmark simulation, the prices of hydrogen and non-hydrogen vehicles are comparable. Due to fuel efficiency, hydrogen vehicles have a fuel savings advantage of 9.8 cents per mile over non-hydrogen vehicles. Hydrogen vehicles account for 60% of new vehicle sales in 20 years from the initial entry of hydrogen vehicles into show rooms, going on to 86% in 40 years and reaching still higher values after that. If the fuel savings is 20.7 cents per mile for a hydrogen vehicle, penetration reaches 86% of new car sales by the 20th year. If the fuel savings is 0.5 cents per mile, market penetration reaches only 10% by the 20th year. To turn to vehicle price difference, if a hydrogen vehicle costs $2,000 less than a non-hydrogen vehicle, new car sales penetration reaches 92% by the 20th year. If a hydrogen vehicle costs $6,500 more than a non-hydrogen vehicle, market penetration is only 6% by the 20th year. Results from other sensitivity runs are presented. Policies that could affect hydrogen vehicle adoption are investigated. A tax credit for the purchase of a hydrogen vehicle of $2,500 tax credit results in 88% penetration by the 20th year, as compared with 60% in the benchmark case. If the tax credit is $6,000, penetration is 99% by the 20th year. Under a more modest approach, the tax credit would be available only for the first 10 years. Hydrogen sales penetration then reach 69% of sales by the 20th year with the $2,500 credit and 79% with the $6,000 credit. A carbon tax of $38 per metric ton is not large enough to noticeably affect sales penetration. A tax of $116 per metric ton makes centrally produced hydrogen profitable in the very first year but results in only 64% penetration by year 20 as opposed to the 60% penetration in the benchmark case. Provision of 15 seed stations publicly provided at the beginning of the simulation, in addition to the 15 existing stations in the benchmark case, gives sales penetration rates very close to the benchmark after 20 years, namely, 63% and 59% depending on where they are placed.

Tolley, George S

2010-06-29T23:59:59.000Z

368

Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 |  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power.pdf11-161-LNG |September 15,2015Department ofRequirementsEnergyJDicksonDepartment

369

Cybersecurity for Energy Delivery Systems (CEDS) Research Call | Department  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergy Cooperation |South42.2Consolidated Edison5 by ISA -of Energy Cybersecurity for Energy

370

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana. DOCUMENTS AVAILABLEReport 2009Site |Documents Available forCSPM is theBest

371

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana. DOCUMENTS AVAILABLEReport 2009Site |Documents Available forCSPM is

372

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana. DOCUMENTS AVAILABLEReport 2009Site |Documents Available forCSPM isSecure

373

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana. DOCUMENTS AVAILABLEReport 2009Site |Documents Available forCSPM

374

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana. DOCUMENTS AVAILABLEReport 2009Site |Documents Available forCSPMTrustworthy

375

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana. DOCUMENTS AVAILABLEReport 2009Site |Documents Available

376

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana. DOCUMENTS AVAILABLEReport 2009Site |Documents AvailableVulnerability and

377

Tank Waste Feed Delivery System Readiness at the Hanford Site  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energy Usage »of Energy StrainClient updateTRI-STATE GENERATION 1.Take9/09Audit Report

378

Vulnerability Analysis of Energy Delivery Control Systems (September 2011)  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartment of EnergyofProject is onModeling andReportandV ie w o nlNovemberVote For the

379

Vulnerability Analysis of Energy Delivery Control Systems - 2011 |  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartment of EnergyofProject is onModeling andReportandV ie w o nlNovemberVote For

380

Ammonia storage and delivery systems for NOx aftertreatment | Department of  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartment ofEnergy Natural Gas:Austin, TMOAB,Motor Challenge

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Dynamic Line Rating Oncor Electric Delivery Smart Grid Program  

SciTech Connect (OSTI)

Electric transmission lines are the lifeline of the electric utility industry, delivering its product from source to consumer. This critical infrastructure is often constrained such that there is inadequate capacity on existing transmission lines to efficiently deliver the power to meet demand in certain areas or to transport energy from high-generation areas to high-consumption regions. When this happens, the cost of the energy rises; more costly sources of power are used to meet the demand or the system operates less reliably. These economic impacts are known as congestion, and they can amount to substantial dollars for any time frame of reference: hour, day or year. There are several solutions to the transmission constraint problem, including: construction of new generation, construction of new transmission facilities, rebuilding and reconductoring of existing transmission assets, and Dynamic Line Rating (DLR). All of these options except DLR are capital intensive, have long lead times and often experience strong public and regulatory opposition. The Smart Grid Demonstration Program (SGDP) project co-funded by the Department of Energy (DOE) and Oncor Electric Delivery Company developed and deployed the most extensive and advanced DLR installation to demonstrate that DLR technology is capable of resolving many transmission capacity constraint problems with a system that is reliable, safe and very cost competitive. The SGDP DLR deployment is the first application of DLR technology to feed transmission line real-time dynamic ratings directly into the system operation’s State Estimator and load dispatch program, which optimizes the matching of generation with load demand on a security, reliability and economic basis. The integrated Dynamic Line Rating (iDLR)1 collects transmission line parameters at remote locations on the lines, calculates the real-time line rating based on the equivalent conductor temperature, ambient temperature and influence of wind and solar radiation on the stringing section, transmits the data to the Transmission Energy Management System, validates its integrity and passes it on to Oncor and ERCOT (Electric Reliability Council of Texas) respective system operations. The iDLR system is automatic and transparent to ERCOT System Operations, i.e., it operates in parallel with all other system status telemetry collected through Supervisory Control and Data Acquisition (SCADA) employed across the company.

Johnson, Justin; Smith, Cale; Young, Mike; Donohoo, Ken; Owen, Ross; Clark, Eddit; Espejo, Raul; Aivaliotis, Sandy; Stelmak, Ron; Mohr, Ron; Barba, Cristian; Gonzalez, Guillermo; Malkin, Stuart; Dimitrova, Vessela; Ragsdale, Gary; Mitchem, Sean; Jeirath, Nakul; Loomis, Joe; Trevino, Gerardo; Syracuse, Steve; Hurst, Neil; Mereness, Matt; Johnson, Chad; Bivens, Carrie

2013-05-04T23:59:59.000Z

382

Agenda for the Hydrogen Delivery and Onboard Storage Analysis...  

Broader source: Energy.gov (indexed) [DOE]

- T. P. Chen, Nexant 2:45 pm Break 3:00 pm Hydrogen Delivery Demonstrations - Ed Kiczek, Air Products & Chemicals, Inc. 3:10 pm Pathway Cost Distributions: Fuel Pathway...

383

Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...  

Broader source: Energy.gov (indexed) [DOE]

8:15 H2A Delivery Model Changes and Discussion: Matt Hooks (TIAX LLC), Bruce Kelly (Nexant), Jerry Gillette (ANL), Matt Ringer (NREL), Amgad Elgowainy (ANL) 8:15...

384

,"New York Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

,,"(202) 586-8800",,,"182015 12:47:52 PM" "Back to Contents","Data 1: New York Natural Gas Deliveries to Electric Power Consumers (MMcf)" "Sourcekey","N3045NY2"...

385

Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions  

E-Print Network [OSTI]

This thesis focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer ...

Macdonald, Mara Lee

2010-01-01T23:59:59.000Z

386

Design of an underwater vertical glider for subsea equipment delivery  

E-Print Network [OSTI]

Delivery of subsea equipment and sensors is generally accomplished with unguided sinking platforms or powered autonomous underwater vehicles (AUVs). An alternative would be to augment existing platforms with navigation and ...

Ambler, Charles Kirby

2010-01-01T23:59:59.000Z

387

Delivery optimization for a make to order custom wire mill  

E-Print Network [OSTI]

In the face of growing competition in the Tantalum business, H.C.Starck's management is minimizing the delivery time for custom-made capacitor-grade tantalum wire products. H.C. Starck, Inc., Newton, Massachusetts faces ...

Slivinskiy, Andrey L

2005-01-01T23:59:59.000Z

388

Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other...  

Broader source: Energy.gov (indexed) [DOE]

Assumes 2005 delivery technologies * We can insert our Research Targets to see the impact Hydrogen Plants can be Located Relatively Near the Market demand Nearly all areas East of...

389

Determining the Lowest-Cost Hydrogen Delivery Mode  

E-Print Network [OSTI]

Costs to Estimate Hydrogen Pipeline Costs. 2004, ITS-Davis:hydrogen. The cost of hydrogen pipeline delivery depends onCosts to Estimate Hydrogen Pipeline Costs. 2004, ITS-Davis:

Yang, Christopher; Ogden, Joan M

2008-01-01T23:59:59.000Z

390

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform  

E-Print Network [OSTI]

Rapid mechanical deformation of cells has emerged as a promising, vector-free method for intracellular delivery of macromolecules and nanomaterials. This technology has shown potential in addressing previously challenging ...

Sharei, Armon Reza

391

A vector-free microfluidic platform for intracellular delivery  

E-Print Network [OSTI]

Intracellular delivery of macromolecules is a challenge in research and therapeutic applications. Existing vector-based and physical methods have limitations, including their reliance on exogenous materials or electrical ...

Sharei, Armon Reza

392

Office of Electricity Delivery and Energy Reliability, OE-20  

Broader source: Energy.gov (indexed) [DOE]

6, 2012 Office of Electricity Delivery and Energy Reliability, OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585 RE: Comments for Consideration in...

393

Lamont Jackson Office of Electricity Delivery and Energy Reliability  

Energy Savers [EERE]

March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue, S.W. Washington, D.C....

394

Mr. Lamont Jackson Office of Electricity Delivery and Energy...  

Energy Savers [EERE]

March 28, 2012 Mr. Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585...

395

Lamont Jackson Office of Electricity Delivery and Energy Reliability  

Energy Savers [EERE]

March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, D.C. 20585...

396

Vacancy Announcements Posted for Hydrogen Production and Delivery Program  

Broader source: Energy.gov [DOE]

The Fuel Cell Technologies Office has posted two vacancy announcements for a position to serve as Program Manager for the Hydrogen Production and Delivery Program in the DOE EERE Fuel Cell Technologies Office. The closing date is October 28, 2014.

397

Fact Sheet: Codes and Standards for Energy Storage System Performance...  

Broader source: Energy.gov (indexed) [DOE]

The U.S. Department of Energy's Office of Electricity Delivery and Energy Reliability Energy Storage Systems Program, with the support of Pacific Northwest National Laboratory...

398

Evaluating Feed Delivery Performance in Scaled Double-Shell Tanks  

SciTech Connect (OSTI)

The Hanford Tank Operations Contractor (TOC) and the Hanford Waste Treatment and Immobilization Plant (WTP) contractor are both engaged in demonstrating mixing, sampling, and transfer system capability using simulated Hanford High-Level Waste (HLW) formulations. This work represents one of the remaining technical issues with the high-level waste treatment mission at Hanford. The TOCs' ability to adequately mix and sample high-level waste feed to meet the WTP WAC Data Quality Objectives must be demonstrated. The tank mixing and feed delivery must support both TOC and WTP operations. The tank mixing method must be able to remove settled solids from the tank and provide consistent feed to the WTP to facilitate waste treatment operations. Two geometrically scaled tanks were used with a broad spectrum of tank waste simulants to demonstrate that mixing using two rotating mixer jet pumps yields consistent slurry compositions as the tank is emptied in a series of sequential batch transfers. Testing showed that the concentration of slow settling solids in each transfer batch was consistent over a wide range of tank operating conditions. Although testing demonstrated that the concentration of fast settling solids decreased by up to 25% as the tank was emptied, batch-to-batch consistency improved as mixer jet nozzle velocity in the scaled tanks increased.

Lee, Kearn P. [AREVA Federal Services LLC (United States); Thien, Michael G. [Washington River Protection Systems, Richland, WA (United States)

2013-11-07T23:59:59.000Z

399

Energy-Aware Load Balancing in Content Delivery Networks  

E-Print Network [OSTI]

Internet-scale distributed systems such as content delivery networks (CDNs) operate hundreds of thousands of servers deployed in thousands of data center locations around the globe. Since the energy costs of operating such a large IT infrastructure are a significant fraction of the total operating costs, we argue for redesigning CDNs to incorporate energy optimizations as a first-order principle. We propose techniques to turn off CDN servers during periods of low load while seeking to balance three key design goals: maximize energy reduction, minimize the impact on client-perceived service availability (SLAs), and limit the frequency of on-off server transitions to reduce wear-and-tear and its impact on hardware reliability. We propose an optimal offline algorithm and an online algorithm to extract energy savings both at the level of local load balancing within a data center and global load balancing across data centers. We evaluate our algorithms using real production workload traces from a large commercial ...

Mathew, Vimal; Shenoy, Prashant

2011-01-01T23:59:59.000Z

400

Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery (Presentation)  

SciTech Connect (OSTI)

This presentation summarizes "A Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery".

Jalalzadeh-Azar, A.

2010-10-18T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Liguid and Solid Carriers Group- Strategic Directions for Hydrogen Delivery Workshop  

Broader source: Energy.gov [DOE]

Targets, barriers and research and development priorities for solid and liquid hydrogen storage and delivery materials.

402

Target isolation system, high power laser and laser peening method and system using same  

DOE Patents [OSTI]

A system for applying a laser beam to work pieces, includes a laser system producing a high power output beam. Target delivery optics are arranged to deliver the output beam to a target work piece. A relay telescope having a telescope focal point is placed in the beam path between the laser system and the target delivery optics. The relay telescope relays an image between an image location near the output of the laser system and an image location near the target delivery optics. A baffle is placed at the telescope focal point between the target delivery optics and the laser system to block reflections from the target in the target delivery optics from returning to the laser system and causing damage.

Dane, C. Brent (Livermore, CA); Hackel, Lloyd A. (Livermore, CA); Harris, Fritz (Rocklin, CA)

2007-11-06T23:59:59.000Z

403

Economic and Conservation Evaluation of Capital Renovation Projects: Harlingen Irrigation District Cameron County No. 1 Canal Meters and Telemetry Equipment, Impervious-Lining of Delivery Canals, Pipelines Replacing Delivery Canals, and On-Farm Delivery-Site Meters  

E-Print Network [OSTI]

, impervious-lining of delivery canals, 24" pipelines replacing delivery canals, and on-farm delivery-site meters). Sensitivity results for both the cost of water savings and cost of energy savings are presented for several important parameters. Expected cost...

Rister, M. Edward; Lacewell, Ronald D.; Sturdivant, Allen W.; Robinson, John R.C.; Popp, Michael C.; Ellis, John R.

404

Cost Comparison of Collaborative and IPD-like Project Delivery Methods Versus Competitive Non-collaborative Project Delivery Methods  

E-Print Network [OSTI]

Collaborative project delivery methods are believed to contribute to faster completions times, lower overall project costs and higher quality. Contracts are expected to influence the degree of collaboration on a given project since they allow...

Kulkarni, Aditi

2012-07-16T23:59:59.000Z

405

IDC System Specification Document.  

SciTech Connect (OSTI)

This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris

Clifford, David J.

2014-12-01T23:59:59.000Z

406

Nitrous Oxide Systems Maintenance in Clinical Areas  

E-Print Network [OSTI]

. It specifically speaks to maintenance of nitrous oxide delivery systems, preventive maintenance for house. Arrange with Facilities for regular preventive maintenance and annual performance check of ventilation). b. Provides preventive maintenance on ventilation system as necessary. c. Coordinates annual

Jia, Songtao

407

Strategic Directions for Hydrogen Delivery Workshop Proceedings  

Broader source: Energy.gov (indexed) [DOE]

including water or oil pipelines for hydrogen transport Assess viability of natural gas safety systems when hydrogen is introduced Conduct field demonstra- tion of hydrogen...

408

Tank Farms and Waste Feed Delivery - 12507  

SciTech Connect (OSTI)

The mission of the Department of Energy's Office of River Protection (ORP) is to safely retrieve and treat the 56 million gallons of Hanford's tank waste and close the Tank Farms to protect the Columbia River. Our discussion of the Tank Farms and Waste Feed Delivery will cover progress made to date with Base and Recovery Act funding in reducing the risk posed by tank waste and in preparing for the initiation of waste treatment at Hanford. The millions of gallons of waste are a by-product of decades of plutonium production. After irradiated fuel rods were taken from the nuclear reactors to the processing facilities at Hanford they were exposed to a series of chemicals designed to dissolve away the rod, which enabled workers to retrieve the plutonium. Once those chemicals were exposed to the fuel rods they became radioactive and extremely hot. They also couldn't be used in this process more than once. Because the chemicals are caustic and extremely hazardous to humans and the environment, underground storage tanks were built to hold these chemicals until a more permanent solution could be found. The underground storage tanks range in capacity from 55,000 gallons to more than 1 million gallons. The tanks were constructed with carbon steel and reinforced concrete. There are eighteen groups of tanks, called 'tank farms', some having as few as two tanks and others up to sixteen tanks. Between 1943 and 1964, 149 single-shell tanks were built at Hanford in the 200 West and East Areas. Heat generated by the waste and the composition of the waste caused an estimated 67 of these single-shell tanks to leak into the ground. Washington River Protection Solutions is the prime contractor responsible for the safe management of this waste. WRPS' mission is to reduce the risk to the environment that is posed by the waste. All of the pumpable liquids have been removed from the single-shell tanks and transferred to the double-shell tanks. What remains in the single-shell tanks are solid and semi-solid wastes. Known as salt-cakes, they have the consistency of wet beach sand. Some of the waste resembles small broken ice, or whitish crystals. Because the original pumps inside the tanks were designed to remove only liquid waste, other methods have been developed to reach the remaining waste. Access to the tank waste is through long, typically skinny pipes, called risers, extending out of the tanks. It is through these pipes that crews are forced to send machines and devices into the tanks that are used to break up the waste or push it toward a pump. These pipes range in size from just a few inches to just over a foot in diameter because they were never intended to be used in this manner. As part of the agreement regulating Hanford cleanup, crews must remove at least 99% of the material in every tank on the site, or at least as much waste that can be removed based on available technology. To date, seven single-shell tanks have been emptied, and work is underway in another 10 tanks in preparation for additional retrieval activities. Two barriers have been installed over single-shell tanks to prevent the intrusion of surface water down to the tanks, with additional barriers planned for the future. Single and double-shell tank integrity analyses are ongoing. Because the volume of the waste generated through plutonium production exceeded the capacity of the single-shell tanks, between 1968 and 1986 Hanford engineers built 28 double-shell tanks. These tanks were studied and made with a second shell to surround the carbon steel and reinforced concrete. The double-shell tanks have not leaked any of their waste. (authors)

Fletcher, Thomas; Charboneau, Stacy; Olds, Erik [US DOE (United States)

2012-07-01T23:59:59.000Z

409

antiepileptic drug effects: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

410

Delivery, design, and mechanism of antimicrobial peptides  

E-Print Network [OSTI]

Each year, 2 million people contract hospital-acquired bacterial infections, which causes the death of 100,000 patients and costs the US healthcare system over $21 billion. These infections have become dangerously resistant ...

Chau, Tanguy

2010-01-01T23:59:59.000Z

411

Process management applications in biopharmaceutical drug production  

E-Print Network [OSTI]

Genzyme's manufacturing and supply chain organization is responsible for the production and delivery of medically necessary medicines for patients with rare diseases around the world. Because of the nature of the products ...

Smith, Stephen E

2011-01-01T23:59:59.000Z

412

Volatile Delivery to Planets from Water-rich Planetesimals around Low Mass Stars  

E-Print Network [OSTI]

Most models of volatile delivery to accreting terrestrial planets assume that the carriers for water are similar in water content to the carbonaceous chondrites in our Solar System. Here we suggest that the water content of primitive bodies in many planetary systems may actually be much higher, as carbonaceous chondrites have lost some of their original water due to heating from short-lived radioisotopes that drove parent body alteration. Using N-body simulations, we explore how planetary accretion would be different if bodies beyond the water line contained a water mass fraction consistent with chemical equilibrium calculations, and more similar to comets, as opposed to the more traditional water-depleted values. We apply this model to consider planet formation around stars of different masses and identify trends in the properties of Habitable Zone planets and planetary system architecture which could be tested by ongoing exoplanet census data collection. Comparison of such data with the model predicted tren...

Ciesla, Fred J; Pascucci, Ilaria; Apai, Daniel

2015-01-01T23:59:59.000Z

413

Delivery of MicroR A-10b with Polylysine Nanoparticles for Inhibition...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delivery of MicroR A-10b with Polylysine Nanoparticles for Inhibition of Breast Cancer Cell Wound Healing. Delivery of MicroR A-10b with Polylysine Nanoparticles for Inhibition of...

414

Using Integrated Project Delivery (IPD) to Resolve the Major Construction Project Delay Causes in Saudi Arabia  

E-Print Network [OSTI]

Integrated Project Delivery (IPD) has gained attention in the United States and Europe as an effective delivery method for construction projects. The aim of this research paper is to determine the major causes of delay in ...

Alkhalid, Khalid Abdullah

2011-12-16T23:59:59.000Z

415

Proton Delivery and Removal in [Ni(PR2NR?2)2]2+ Hydrogen...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delivery and Removal in Ni(PR2NR?2)22+ Hydrogen Production and Oxidation Catalysts. Proton Delivery and Removal in Ni(PR2NR?2)22+ Hydrogen Production and Oxidation...

416

Apatite-Polymer Composite Particles for Controlled Delivery of BMP-2  

E-Print Network [OSTI]

We have developed a versatile delivery platform comprising a novel composite of two biomaterials with proven track records: apatite and poly(lactic-co-glycolic acid) (PLGA). These composites have been tested in the delivery ...

Yong, Tseh-Hwan

417

Three-Dimensional Simulation of Carmustine Delivery to a Patient-Specific Brain Tumor  

E-Print Network [OSTI]

This study presents the recent development of three-dimensional patient-specific simulation of carmustine delivery to brain tumor that highlights several crucial factors affecting the delivery. The simulation utilizes the ...

Arifin, Davis Yohanes

418

Cell squeezing : a vector-free microfluidic platform for intracellular delivery of macromolecules  

E-Print Network [OSTI]

Intracellular delivery of material is a long-standing challenge for both therapeutic and research applications. Existing technologies rely on a variety of mechanisms to facilitate delivery. Vector-based methods, such as ...

Sharei, Armon R. (Armon Reza)

2013-01-01T23:59:59.000Z

419

The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier  

E-Print Network [OSTI]

It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells. An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is ...

Wang, Jing

2008-01-01T23:59:59.000Z

420

Direct encapsulation of water-soluble drug into silica microcapsules for sustained release applications  

SciTech Connect (OSTI)

Direct encapsulation of water-soluble drug into silica microcapsules was facilely achieved by a sol-gel process of tetraethoxysilane (TEOS) in W/O emulsion with hydrochloric acid (HCl) aqueous solution containing Tween 80 and drug as well as cyclohexane solution containing Span 80. Two water-soluble drugs of gentamicin sulphate (GS) and salbutamol sulphate (SS) were chosen as model drugs. The characterization of drug encapsulated silica microcapsules by scanning electronic microscopy (SEM), FTIR, thermogravimetry (TG) and N{sub 2} adsorption-desorption analyses indicated that drug was successfully entrapped into silica microcapsules. The as-prepared silica microcapsules were uniform spherical particles with hollow structure, good dispersion and a size of 5-10 {mu}m, and had a specific surface area of about 306 m{sup 2}/g. UV-vis and thermogravimetry (TG) analyses were performed to determine the amount of drug encapsulated in the microcapsules. The BJH pore size distribution (PSD) of silica microcapsules before and after removing drug was examined. In vitro release behavior of drug in simulated body fluid (SBF) revealed that such system exhibited excellent sustained release properties.

Wang Jiexin; Wang Zhihui [Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Chen Jianfeng [Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029 (China)], E-mail: chenjf@mail.buct.edu.cn; Yun, Jimmy [Nanomaterials Technology Pte. Ltd., 28 Ayer Rajah Crescent 03-03, Singapore 139959 (Singapore)

2008-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Project Management Business Process Project Delivery Processes Includes VE Budget  

E-Print Network [OSTI]

Project Management Business Process Project Delivery Processes Includes VE Budget Schedule Activities that do/could feed into PMBP LEGEND VE Cost Avoidance Program Coverage Document Results (Before, could use the value methodology to facilitate after action review. The project manager is responsible

US Army Corps of Engineers

422

Scalable Analysis, Verification and Design of IC Power Delivery  

E-Print Network [OSTI]

efficiency for large grids must be improved and the entire network with off-chip models and nonlinear devices should be able to be analyzed. Gated power delivery networks have multiple on/off operating conditions that need to be fully verified against...

Zeng, Zhiyu

2012-02-14T23:59:59.000Z

423

Timely delivery of LIFE Tom Anklam, Lawrence Livermore  

E-Print Network [OSTI]

Timely delivery of LIFE Tom Anklam, Lawrence Livermore National Laboratory October 19, 2011 LIFE_Royal_Society_9/7/11 6 LIFE Fusion Chamber is About the Same Scale as the NIF Target Chamber #12;LIFE Fusion Physics will be Demonstrated on the NIF #12;LIFE will use a modular laser architeccture #12;#12;#12;11 NIF

424

United Parcel Service Evaluates Hybrid Electric Delivery Vans (Fact Sheet)  

SciTech Connect (OSTI)

This fact sheet describes how the National Renewable Energy Laboratory's Fleet Test and Evaluation team evaluated the 12-month, in-service performance of six Class 4 hybrid electric delivery vans - fueled by regular diesel - and six comparable conventional diesel vans operated by the United Parcel Service.

Not Available

2010-02-01T23:59:59.000Z

425

Lipophilic Peptides for Gene Delivery Carla A. H. Prata,  

E-Print Network [OSTI]

University, Boston, Massachusetts 02215, Department of Biological and Environmental Engineering, Cornell laboratories and in ViVo gene delivery holds the promise for curing many diseases. The synthetic carriers of lipophilic peptides including the synthesis, physio- chemical properties, cytotoxicity, and in Vitro gene

426

A Research Infrastructure for SOA-based Service Delivery Frameworks  

E-Print Network [OSTI]

-of-the-art for Service Delivery Platforms (SDPs). In this context, a flexible SDF for telecommunications may serve operators), the SDF allows them to re-use their service enablers, to expose network capabilities. This is the place where a NGN SDF is capable of adding further value-add, the SDF may serve for legacy as well

Wichmann, Felix

427

Time-Critical Data Delivery in Wireless Sensor Networks  

E-Print Network [OSTI]

topology con- trol mechanisms to ensure timely data delivery and reliability control mechanisms to deal refinery in Portugal is used to define protocol requirements. The paper details a TinyOS implementation routing, topology control and reliability control mechanisms to achieve the set goals. This protocol

Roedig, Utz

428

Rural Microfinance Service Delivery: Gaps, Inefficiencies and Emerging Solutions  

E-Print Network [OSTI]

. Historically it has proved difficult to provide sustainable micro- financial services to remote rural clients significant challenges in maturing and scaling to sustainability. We will look at three of the major tasks, 2) management and processing of data at the institutional level and 3) the collection and delivery

Parikh, Tapan S.

429

Creating Efficiencies in Last Mile Delivery through Workforce  

E-Print Network [OSTI]

objectives · Extend the planning horizon to achieve more efficiency · Discuss general trends in workforceCreating Efficiencies in Last Mile Delivery through Workforce Management Maciek Nowak Associate workforce management and its advantages · Discuss new research looking to expand the customer service

Bustamante, Fabián E.

430

Gene Delivery DOI: 10.1002/anie.201302820  

E-Print Network [OSTI]

(10­25 peptide residues) and lack adequate cationic charge to efficiently condense and deliver genes vehicles to improve delivery efficiencies.[11] We recently developed high-molecular-weight (MW), cationic efficiency and chemotoxicity of these polymeric vectors are often closely related to the density

Cheng, Jianjun

431

Hydrogen Delivery Analysis Amgad Elgowainy (ANL), Marianne Mintz  

E-Print Network [OSTI]

Hydrogen Truck Liquid Hydrogen Truck Terminal H2 Transmission Compressor H2 Forecourt Compressor Hydrogen Storage Options Geologic gas storage Low cost for very large amounts of hydrogen May not be convenientlyHydrogen Delivery Analysis Models Amgad Elgowainy (ANL), Marianne Mintz (ANL), Jerry Gillette (ANL

432

Project Startup: Evaluating Coca-Cola's Class 8 Hybrid-Electric Delivery Trucks (Fact Sheet)  

SciTech Connect (OSTI)

Fact sheet describing the project startup for evaluating Coca-Cola's Class 8 hybrid-electric delivery trucks.

Not Available

2011-03-01T23:59:59.000Z

433

DOE and FreedomCAR and Fuel Partnership Hydrogen Delivery and...  

Broader source: Energy.gov (indexed) [DOE]

Technical Teams for Delivery, Storage, and Fuels Pathway Integration (including automobile and energy company representatives), analysts, and national laboratories....

434

Biodegradable thermosensitive polymeric micelles based on methacrylamide-oligolactates as carrier system for photosensitizers  

E-Print Network [OSTI]

of the micelles (Figure 1). Figure 1 General concept of thermosensitive biodegradable polymeric micelles. The hydrophobic micellar core and its destabilization at physiological conditions can be exploited for controlled delivery of hydrophobic drugs... to tumour regions (Figure 2). Aim The application of biodegradable thermosensitive polymeric micelles and their use for targeted delivery of photosensitizers to cancer cells. Synthesis monomers and polymers Monodisperse methacrylamide oligolactates were...

Rijcken, C. J. F.; Hofman, J. W.; Van Zeeland, F.; Ramzi, A.; Leemhuis, M.; Van Nostrum, C. F.; Hennink, W. E.

2006-10-25T23:59:59.000Z

435

The Impact of Retail Rate Structures on the Economics of Commercial Photovoltaic Systems in California  

E-Print Network [OSTI]

Photovoltaic Systems in California Prepared for the National Renewable Energy Laboratory Golden, Colorado and the Office of Electricity Delivery and Energy Reliability

Wiser, Ryan; Mills, Andrew; Barbose, Galen; Golove, William

2007-01-01T23:59:59.000Z

436

Energy Storage & Delivery The goal of this project is to deliver measurement methods specific to  

E-Print Network [OSTI]

Energy Storage & Delivery Materials The goal of this project is to deliver measurement methods specific to polymeric and organic materials needed in next generation energy storage and delivery. · The NIST team is works closely with leaders in the energy storage and delivery field, including General

437

Human SCO1 and SCO2 have independent, cooperative functions in copper delivery  

E-Print Network [OSTI]

Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c understood, roles in copper delivery to cytochrome c oxidase (COX). Mutations in these genes pro- duce tissue copper delivery pathway in SCO1 and SCO2 patient backgrounds. Immunoblot analysis of patient cell lines

Shoubridge, Eric

438

Pure Insulin Nanoparticle Agglomerates for Pulmonary Delivery  

E-Print Network [OSTI]

particles (top-down). 28 In both mechanisms, the total surface are increases, whic increases the fre enrgy of the particles. The system compensates for this increase in fre nergy by dissolving crystaline uclei and precipitating ont other particles in a... at mbient teperature and pressure, it can simply be flash vaporized at tospheric pressure, leaving behind any extracted solvent and impurites. This eliminates the xtraction medium striping step from the process, making it ore conomical and less enrgy...

Bailey, Mark Michael

2008-04-29T23:59:59.000Z

439

IEEE Transactions on Power Delivery, Vol. 21, No.1, Jan. 2006, pp. 362-367. Instantaneous Reactive Power p-q Theory and Power Properties  

E-Print Network [OSTI]

IEEE Transactions on Power Delivery, Vol. 21, No.1, Jan. 2006, pp. 362-367. Instantaneous Reactive and interpreted by the Instantaneous Reactive Power (IRP) p-q Theory. The paper demonstrates that this theory misinterprets power properties of electrical systems or provides some results that at least defy a common sense

Czarnecki, Leszek S.

440

UC Santa Cruz Information Technology Strategic Plan 2014 The primary mission of ITS is to provide high quality infrastructure, support, and innovation in the delivery of information  

E-Print Network [OSTI]

of resources resulted in an organization more well-situated to manage infrastructure, systems, and services high quality infrastructure, support, and innovation in the delivery of information technology products and directives for the organization and management of information technology at UCSC. This ITS Strategic Plan

California at Santa Cruz, University of

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Using computational fluid dynamics (CFD) to improve the bi-directional nasal drug delivery concept M Kleven1,2  

E-Print Network [OSTI]

M Kleven1,2 , MC Melaaen2 , M Reimers3 , JS Røtnes4,5 , L Aurdal5,6 , PG Djupesland7 ABSTRACT Nasal

Reimers, Martin

442

Hydrogels as Biomaterials: Infinite Possibilities in Bionanotechnology, Drug Delivery, Biological Recognition,Tissue Engineering, and Pure Scientific Fun!  

E-Print Network [OSTI]

the versatility of these biopolymeric materials. Of specific interest are applications requiring the patterning

Peppas, Nicholas A.

443

In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles  

E-Print Network [OSTI]

Cancer is the collective group of diseases distinguished by uninhibited growth and spread of abnormal cells. It often results in death if the spread is not controlled. Most cancers are treated by surgery, radiation, ...

Miller, Michelle Teresa

2009-01-01T23:59:59.000Z

444

Neuroimaging for drug addiction and related behaviors  

SciTech Connect (OSTI)

In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

2011-10-01T23:59:59.000Z

445

Use of Preventative and Therapeutic Drugs in Show Market Animals  

E-Print Network [OSTI]

Various preventive and therapeutic medicines may be used for disease management in show mar- ket livestock and poultry. These include vaccines and bacterins, antibiotics and antibacterials, para- siticides and corticosteroids. Exhibitors of show ani.... These instructions are to be followed precisely. L-2335 2-01 Use of Preventive and Therapeutic Drugs in Show Market Animals F.C. Faries, Jr. Associate Professor and Extension Program Leader for Veterinary Medicine The Texas A&M University System Testing The Food...

Faries Jr., Floron C.

2001-03-12T23:59:59.000Z

446

Rethinking America’s Illegal Drug Policy  

E-Print Network [OSTI]

treatment); health care costs (drug-related illnesses, injuries); reduced performance in school; reduced performance at workplace; poor parenting, child abuse;

Donohue III, John J.

2011-01-01T23:59:59.000Z

447

FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS  

E-Print Network [OSTI]

Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs ...

Flynn, Colleen A.

2011-12-31T23:59:59.000Z

448

Introduction: Integrating pH sensors in microfluidic systems can provide in-situ measurement functionality for micro-scale fluidic processing and analyzing applications, especially for medicine synthesis, bioanalysis of drugs  

E-Print Network [OSTI]

Introduction: Integrating pH sensors in microfluidic systems can provide in-situ measurement to monitor pH levels inside microfluidic channels using pH responsive dyes or tag-based indicators possess dynamic responses. The use of miniaturized electrochemical pH sensors for microfluidic systems have been

Chiao, Jung-Chih

449

Comparison of Waste Feed Delivery Small Scale Mixing Demonstration Simulant to Hanford Waste  

SciTech Connect (OSTI)

The Hanford double-shell tank (DST) system provides the staging location for waste that will be transferred to the Hanford Tank Waste Treatment and Immobilization Plant (WTP). Specific WTP acceptance criteria for waste feed delivery describe the physical and chemical characteristics of the waste that must be met before the waste is transferred from the DSTs to the WTP. One of the more challenging requirements relates to the sampling and characterization of the undissolved solids (UDS) in a waste feed DST because the waste contains solid particles that settle and their concentration and relative proportion can change during the transfer of the waste in individual batches. A key uncertainty in the waste feed delivery system is the potential variation in UDS transferred in individual batches in comparison to an initial sample used for evaluating the acceptance criteria. To address this uncertainty, a number of small-scale mixing tests have been conducted as part of Washington River Protection Solutions' Small Scale Mixing Demonstration (SSMD) project to determine the performance of the DST mixing and sampling systems. A series of these tests have used a five-part simulant composed of particles of different size and density and designed to be equal or more challenging than AY-102 waste. This five-part simulant, however, has not been compared with the broad range of Hanford waste, and thus there is an additional uncertainty that this simulant may not be as challenging as the most difficult Hanford waste. The purpose of this study is to quantify how the current five-part simulant compares to all of the Hanford sludge waste, and to suggest alternate simulants that could be tested to reduce the uncertainty in applying the current testing results to potentially more challenging wastes.

Wells, Beric E.; Gauglitz, Phillip A.; Rector, David R.

2012-07-10T23:59:59.000Z

450

Comparison of Waste Feed Delivery Small Scale Mixing Demonstration Simulant to Hanford Waste  

SciTech Connect (OSTI)

The Hanford double-shell tank (DST) system provides the staging location for waste that will be transferred to the Hanford Tank Waste Treatment and Immobilization Plant (WTP). Specific WTP acceptance criteria for waste feed delivery describe the physical and chemical characteristics of the waste that must be met before the waste is transferred from the DSTs to the WTP. One of the more challenging requirements relates to the sampling and characterization of the undissolved solids (UDS) in a waste feed DST because the waste contains solid particles that settle and their concentration and relative proportion can change during the transfer of the waste in individual batches. A key uncertainty in the waste feed delivery system is the potential variation in UDS transferred in individual batches in comparison to an initial sample used for evaluating the acceptance criteria. To address this uncertainty, a number of small-scale mixing tests have been conducted as part of Washington River Protection Solutions' Small Scale Mixing Demonstration (SSMD) project to determine the performance of the DST mixing and sampling systems. A series of these tests have used a five-part simulant composed of particles of different size and density and designed to be equal or more challenging than AY-102 waste. This five-part simulant, however, has not been compared with the broad range of Hanford waste, and thus there is an additional uncertainty that this simulant may not be as challenging as the most difficult Hanford waste. The purpose of this study is to quantify how the current five-part simulant compares to all of the Hanford sludge waste, and to suggest alternate simulants that could be tested to reduce the uncertainty in applying the current testing results to potentially more challenging wastes.

Wells, Beric E.; Gauglitz, Phillip A.; Rector, David R.

2011-09-01T23:59:59.000Z

451

Analysis on the Go: Quantitation of Drugs of Abuse in Dried Urine with Digital Microfluidics and Miniature Mass Spectrometry  

E-Print Network [OSTI]

Analysis on the Go: Quantitation of Drugs of Abuse in Dried Urine with Digital Microfluidics the development of a method coupling microfluidics and a miniature mass spectrometer, applied to quantitation of drugs of abuse in urine. A custom digital microfluidic system was designed to deliver droplets

Zandstra, Peter W.

452

Pricing in the Market for Anticancer Drugs  

E-Print Network [OSTI]

In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab— brand name Yervoy—at $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

Howard, David H.

453

Chemical Innovation in Drug Dr Matthew Fuchter  

E-Print Network [OSTI]

Chemical Innovation in Drug Discovery Dr Matthew Fuchter Lecturer in Synthetic and Medicinal&D Spending and Output #12;Chemical Innovation Impact Discovery Development Basic research: years 0-3 Pre 3, File DRUG Chemical start point Hit to lead Preclinical Assessment Synthetic Chemistry Chemistry

454

The World of Youthful Drug Use  

E-Print Network [OSTI]

they meet the fact that the use of drugs is illegal and exposes them to arrest and criminal prosecution. It was obvious that such kinds of information could be secured: only from the youths who were themselves in the drug using world. We could not rely on a...

Blumer, Herbert; Sutter, Alan; Smith, Roger; Ahmed, Samir

2000-04-01T23:59:59.000Z

455

New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis  

E-Print Network [OSTI]

We report results of an experimental study, complemented by detailed statistical analysis of the experimental data, on the development of a more effective control method of drug delivery using a pH sensitive acrylic polymer. New copolymers based on acrylic acid and fatty acid are constructed from dodecyl castor oil and a tercopolymer based on methyl methacrylate, acrylic acid and acryl amide were prepared using this new approach. Water swelling characteristics of fatty acid, acrylic acid copolymer and tercopolymer respectively in acid and alkali solutions have been studied by a step-change method. The antibiotic drug cephalosporin and paracetamol have also been incorporated into the polymer blend through dissolution with the release of the antibiotic drug being evaluated in bacterial stain media and buffer solution. Our results show that the rate of release of paracetamol getss affected by the pH factor and also by the nature of polymer blend. Our experimental data have later been statistically analyzed to quantify the precise nature of polymer decay rates on the pH density of the relevant polymer solvents. The time evolution of the polymer decay rates indicate a marked transition from a linear to a strictly non-linear regime depending on the whether the chosen sample is a general copolymer (linear) or a tercopolymer (non-linear). Non-linear data extrapolation techniques have been used to make probabilistic predictions about the variation in weight percentages of retained polymers at all future times, thereby quantifying the degree of efficacy of the new method of drug delivery.

N. Panja; A. K. Chattopadhyay

2014-12-05T23:59:59.000Z

456

System architecture of a consulting engineering services firm and its application to information system development  

E-Print Network [OSTI]

Building Information Systems (IS) requires employees to have a clear understanding of not only the daily work of the company, but of value delivery mechanisms throughout the firm. The three major success factors for IS ...

Martino, Rachael Eileen Applebee

2007-01-01T23:59:59.000Z

457

Superconductivity for Electric Systems  

E-Print Network [OSTI]

1 Superconductivity for Electric Systems Superconductivity Program Quarterly Progress Report For the Period October 1, 2006, to December 31, 2006 #12;2 Superconductivity Program Quarterly Progress Report Superconductivity Program Oak Ridge National Laboratory For U.S. Department of Energy Office of Electricity Delivery

458

Superconductivity for Electric Systems  

E-Print Network [OSTI]

Superconductivity for Electric Systems Superconductivity Program Quarterly Progress Report For the Period January 1, 2007 to March 31, 2007 #12;2 Superconductivity Program Quarterly Progress Report Superconductivity Program Oak Ridge National Laboratory For: Department of Energy Office of Electricity Delivery

459

Superconductivity for Electric Systems  

E-Print Network [OSTI]

Superconductivity for Electric Systems Superconductivity Program Quarterly Progress Report For the Period April 1, 2007, to June 30, 2007 #12;2 Superconductivity Program Quarterly Progress Report Superconductivity Program Oak Ridge National Laboratory For: Department of Energy Office of Electricity Delivery

460

E-Print Network 3.0 - adverse antiepileptic drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... Dosage Same or different? A drug in a different...

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria  

E-Print Network [OSTI]

14 WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria Vincent Breton, Doman Kim ................................................................................ 354 14.2 Grid-Enabled Drug Discovery .................................................. 354 14.2.1 In Silico Drug Discovery: Requirements and Grid Added Value

Paris-Sud XI, Université de

462

Comments of Oncor Electric Delivery Company LLC | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartmentTieCelebrate Earth Codes andDepartment|Crow WingOncor Electric Delivery

463

U.S. Natural Gas % of Total Residential Deliveries (Percent)  

Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines AboutDecemberSteamYearTexas--StateWinter 2013-14 WellsDecade Year-0Formulation/Deliveries

464

U.S. Natural Gas International Deliveries (Million Cubic Feet)  

Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines AboutDecemberSteamYearTexas--StateWinter 2013-14 WellsDecadeCubicYearDecadeDeliveries

465

U.S. Natural Gas Interstate Deliveries (Million Cubic Feet)  

Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines AboutDecemberSteamYearTexas--StateWinter 2013-14Deliveries (Million Cubic Feet) U.S.

466

Electricity Delivery and Energy Reliability | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeat PumpRecord ofESPC ENABLE: ECM Summaryandand TranscriptsElectricity Delivery and

467

Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartment of Energyof the AmericasDOE-STD-3020-2005CodeErnest J.Delivery andDeliveryand

468

Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartment of Energyof the AmericasDOE-STD-3020-2005CodeErnest J.Delivery andDeliveryandand

469

Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartment of Energyof the AmericasDOE-STD-3020-2005CodeErnest J.Delivery

470

US DRIVE Hydrogen Delivery Technical Team Roadmap | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up from theDepartment of Dept. of Energy,UCOR Contract &onEnergyGridDelivery

471

adeno-associated virus-mediated delivery: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for Different Contexts Tayeb Lemlouma1 and Nabil Layada2 OPERA Project present a framework which allows adapted content delivery for different target contexts. This...

472

FY 2014 Budget Request for the Office of Electricity Delivery and Energy Reliability  

Broader source: Energy.gov [DOE]

Table showing the FY 2012 Current Appropriation, the FY 2013 Annualized Continuing Resolution, and the FY 2014 Congressional Request for the Office of Electricity Delivery and Energy Reliability.

473

The Role of Public Utility Commissions in Energy Efficiency Program Delivery  

Broader source: Energy.gov [DOE]

This presentation, given through the DOE's Technical Assitance Program (TAP), addresses the role of public utility commissions in energy efficiency program delivery. Presented on August 31, 2011.

474

U.S. DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY DELIVERY AND...  

Office of Environmental Management (EM)

U.S. DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY 10 ENVIRONMENTAL ASSESSMENT PUBLIC SCOPING MEETING U.S. DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY...

475

Vectren Energy Delivery of Indiana (Electric)- Commercial New Construction Rebates (Indiana)  

Broader source: Energy.gov [DOE]

Vectren Energy Delivery offers commercial customers in Indiana electric rebates for the installation of certain types of equipment in newly constructed buildings. Prescriptive and performance based...

476

DOE Fuel Cell Technologies Office Record 13013: H2 Delivery Cost...  

Office of Environmental Management (EM)

current, and projected costs for delivering and dispensing hydrogen. DOE Hydrogen and Fuel Cells Program Record 13013 More Documents & Publications Hydrogen Delivery Roadmap US...

477

2011 Annual Planning Summary for Electricity Delivery and Energy Reliability (OE)  

Broader source: Energy.gov [DOE]

The ongoing and projected Environmental Assessments and Environmental Impact Statements for 2011 and 2012 within the Office of Electricity Delivery and Energy Reliability (OE).

478

Structural genomics of infectious disease drug targets: the SSGCID...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

479

Drugs and oil flow through the Eagle Ford Shale.  

E-Print Network [OSTI]

??This report is a work of original reporting which investigates the proliferation of drug use and drug trafficking in the Eagle Ford Shale, a region… (more)

Marks, Michael Perry

2014-01-01T23:59:59.000Z

480

E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

antiepileptic drug development: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of drug design and development Bommarius Reading Jan 15 Tutorial Sherrill, David 28 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

482

Delivery of cationic polymer-siRNA nanoparticles for gene therapies in neural regeneration  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Nogo receptor can inhibit growth of injured axons, thus affecting neural regeneration. Black-Right-Pointing-Pointer The delivery of siRNA is crucial to inhibit NgR expression in NSCs. Black-Right-Pointing-Pointer Non-viral vector PEG-PEI condensed siRNA targeting NgR into nanoscale particles. Black-Right-Pointing-Pointer PEG-PEI/siRNA at N/P = 15 displayed high transfection efficiency and low cytotoxicity. Black-Right-Pointing-Pointer PEG-PEI has great potential in carrying siRNA to diminish the gene expression in NSCs. -- Abstract: The therapeutic applications of neural stem cells (NSCs) have potential to promote recovery in many obstinate diseases in central nervous system. Regulation of certain gene expressions using siRNA may have significant influence on the fate of NSC. To achieve the optimum gene silencing effect of siRNA, non-viral vector polyethylene glycol-polyethyleneimine (PEG-PEI) was investigated in the delivery of siRNA to NSCs. The characteristics of PEG-PEI/siRNA polyplexes were detected by scanning electron microscopy (SEM). The effects of nanoparticles on cell viability were measured via CCK-8 assay. In addition, the transfection efficiency was evaluated by fluorescence microscope and flow cytometry, and real-time PCR and Western Blot were employed to detect the gene inhibition effect of siRNA delivered by PEG-PEI. The SEM micrographs showed that PEG-PEI could condense siRNA to form diffuse and spherical nanoparticles. The cytotoxicity of PEG-PEI/siRNA nanocomplexes (N/P = 15) was significantly lower when compared with that of Lipofectamine 2000/siRNA (P < 0.05). Moreover, the highest transfection efficiency of PEG-PEI/siRNA nanoparticles was obtained at an N/P ratio of 15, which was better than that achieved in the transfection using Lipofectamine 2000 (P < 0.05). Finally, the gene knockdown effect of PEG-PEI/siRNA nanoparticles was verified at the levels of mRNA and protein. These results suggest that PEG-PEI may potentially be used as a siRNA delivery vector for neural regeneration therapy.

Liang, Yanran [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Liu, Zhonglin, E-mail: zhonglinliu@126.com [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Shuai, Xintao; Wang, Weiwei [School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China (China)] [School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China (China); Liu, Jun [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Bi, Wei [Department of Neurology, The First Affiliated Hospital of Jinan University, No. 613, West Huangpu Road, Guangzhou 510630, People's Republic of China (China)] [Department of Neurology, The First Affiliated Hospital of Jinan University, No. 613, West Huangpu Road, Guangzhou 510630, People's Republic of China (China); Wang, Chuanming; Jing, Xiuna; Liu, Yunyun [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Tao, Enxiang, E-mail: taoenxiang@yahoo.com.cn [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)

2012-05-18T23:59:59.000Z

483

Intradermal needle-free powdered drug injection  

E-Print Network [OSTI]

This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

Liu, John (John Hsiao-Yung)

2012-01-01T23:59:59.000Z

484

Alcohol and Other Drugs Education and Prevention  

E-Print Network [OSTI]

Free Workplace Policy. 2.0 POLICY STATEMENT In compliance with the federal government's Drug Free, because of Mines' status as a federal contractor and grant recipient and because marijuana use is still

485

Economic and Conservation Evaluation of Capital Renovation Projects: Edinburg Irrigation District Hidalgo County No. 1 - 72" Pipeline Replacing Delivery Canal and Multi-Size Pipeline Replacing Delivery Canal  

E-Print Network [OSTI]

). Both nominal and real, expected economic and financial costs of water and energy savings are identified throughout the anticipated useful lives for both components of the proposed project (i.e., 72" pipeline replacing a segment of delivery canal along...

Rister, M. Edward; Lacewell, Ronald D.; Sturdivant, Allen W.; Robinson, John R.C.; Popp, Michael C.; Ellis, John R.

486

Replacement of the old Mass Storage System by a solution that supports the scientific and operational developments over the next 10 years  

E-Print Network [OSTI]

Replacement of the old Mass Storage System by a solution that supports the scientific to the turnkey delivery of the Mass Storage System (delivery, installation and implementation) the solution also includes the migration of the content of the present to the new Mass Storage System and de- commissioning

Haak, Hein

487

THE COMPETITIVENESS OF COMMERCIAL ELECTRIC VEHICLES IN THE LTL DELIVERY INDUSTRY  

E-Print Network [OSTI]

of electric delivery trucks. To this end, equations linking vehicle performance to power consumption, routeTHE COMPETITIVENESS OF COMMERCIAL ELECTRIC VEHICLES IN THE LTL DELIVERY INDUSTRY: #12; #12, energy use, and costs of electric vehicles and comparable diesel internal-combustion engine vehicles

Bertini, Robert L.

488

Energy-aware Georouting with Guaranteed Delivery in Wireless Sensor Networks with  

E-Print Network [OSTI]

Energy-aware Georouting with Guaranteed Delivery in Wireless Sensor Networks with Obstacles E. H algorithm invokes an energy-aware Face routing that guarantees delivery. Our work is the first to optimize node using only local neighborhood information. Within this framework, energy-aware routing schemes use

Paris-Sud XI, Université de

489

Microfluidic device for delivery of multiple inks for dip pen nanolithography  

E-Print Network [OSTI]

Microfluidic device for delivery of multiple inks for dip pen nanolithography Juan Alberto Rivas of a microfluidic ink delivery device for delivering multiple species of inks to an array of multiple pens, as well as for maximizing the number of inks for simulta- neous patterning by DPN. The microfluidic device called "Centiwell

Banerjee, Debjyoti

490

H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results  

E-Print Network [OSTI]

H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis ...........................................................................2-1 H2A Hydrogen Delivery Models 2.1.5.2 ......................................................................2-10 Refueling Station Compressor 2.1.5.3 ............................2-11 Refueling Station Liquid

491

Specific and efficient in vivo delivery of DNA and siRNA by polyethylenimine and its derivatives  

E-Print Network [OSTI]

Linear polyethylenimine (PEI) is the "gold standard" of polycationic gene delivery vectors. However, little focus has been placed on enhancing or understanding the specificity of PEImediated gene delivery. Herein we evaluated ...

Fortune, Jennifer A

2010-01-01T23:59:59.000Z

492

The Analysis and Development of Large Industrial Steam Systems  

E-Print Network [OSTI]

Chemicals, petroleum, pulp and paper, and many other industries depend heavily on extensive complex steam systems for thermal and mechanical energy delivery. Steam's versatility and desirable characteristics as both a heat transfer medium and a...

Waterland, A. F.

1980-01-01T23:59:59.000Z

493

LN2 Dewar 42 Delivery Overfill Inlet Solution  

SciTech Connect (OSTI)

Pressure vessels must be protected against overpressure scenarios. A scenario of particular concern is that from a high pressure LN2 pump, now standard on LN2 delivery trailers. A safety mechanism must be in place to prevent the overfilling, and subsequent overpressure from occurring because these pumps have a higher mass flow output than reasonably sized relief valves provide. The original solution to the problem was to close a valve on the fill line when a certain liquid level in the dewar is reached. The valve remains closed until the level drops below that threshold. The trigger level was about 13,000 gallons for the 20,000 gallon capacity dewar. The solution was in place from 1989 until present, 2004.

Wu, J.; Mulholland, G.T.; /Fermilab

1991-02-26T23:59:59.000Z

494

Rethinking drug policy: an integrity preserving compromise position  

E-Print Network [OSTI]

Definition of Drug Types?????????????...??.. 4 2 Definition of Drug Scheduling??????????????. 5 1 CHAPTER I INTRODUCTION TO STATUS QUO DRUG POLICY The issue of how to properly regulate the use of illegal.... Legalizers are those who would make legal all currently illegal drugs. The most 3 common middle stance is that of harm reduction, which is ?an alternative approach to drug policy and treatment that focuses on minimizing the adverse effects of both...

Crispino, Azzurra

2006-10-30T23:59:59.000Z

495

Design of a Host Traffic Management system for Hard Real Time networks  

E-Print Network [OSTI]

A Hard Real Time (HRT) system is one whose correct functioning is based on the concepts of timely and correct delivery. By timely delivery, we imply that if a message is dispatched by a sender application it should be delivered at a receiver...

Krishna Moorthy, Jayasankar

1997-01-01T23:59:59.000Z

496

Hydraulic Hybrid and Conventional Parcel Delivery Vehicles' Measured Laboratory Fuel Economy on Targeted Drive Cycles  

SciTech Connect (OSTI)

This research project compares laboratory-measured fuel economy of a medium-duty diesel powered hydraulic hybrid vehicle drivetrain to both a conventional diesel drivetrain and a conventional gasoline drivetrain in a typical commercial parcel delivery application. Vehicles in this study included a model year 2012 Freightliner P100H hybrid compared to a 2012 conventional gasoline P100 and a 2012 conventional diesel parcel delivery van of similar specifications. Drive cycle analysis of 484 days of hybrid parcel delivery van commercial operation from multiple vehicles was used to select three standard laboratory drive cycles as well as to create a custom representative cycle. These four cycles encompass and bracket the range of real world in-use data observed in Baltimore United Parcel Service operations. The NY Composite cycle, the City Suburban Heavy Vehicle Cycle cycle, and the California Air Resources Board Heavy Heavy-Duty Diesel Truck (HHDDT) cycle as well as a custom Baltimore parcel delivery cycle were tested at the National Renewable Energy Laboratory's Renewable Fuels and Lubricants Laboratory. Fuel consumption was measured and analyzed for all three vehicles. Vehicle laboratory results are compared on the basis of fuel economy. The hydraulic hybrid parcel delivery van demonstrated 19%-52% better fuel economy than the conventional diesel parcel delivery van and 30%-56% better fuel economy than the conventional gasoline parcel delivery van on cycles other than the highway-oriented HHDDT cycle.

Lammert, M. P.; Burton, J.; Sindler, P.; Duran, A.

2014-10-01T23:59:59.000Z

497

ECE Department, Boston University 4/17/2011 Title Electrostatic Dry Powder Inhaler for Constant-Dose  

E-Print Network [OSTI]

for improved drug formulation, (2) Design of an electrodynamic dispersion system for respiratory drug delivery-Dose Respiratory Drug Delivery (BME-ECE-ME) Technical areas (1) Pharmaceutical particle surface engineering design process, and (3) Precision mechanical design of an inhalation chamber with computer control Customer

498

Food and drug reward: overlapping circuits in human obesity and addiction  

SciTech Connect (OSTI)

Both drug addiction and obesity can be defined as disorders in which the saliency value of one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to, and at the expense of others. This model is consistent with the fact that both drugs and food have powerful reinforcing effects - partly mediated by dopamine increases in the limbic system - that, under certain circumstances or in vulnerable individuals, could overwhelm the brain's homeostatic control mechanisms. Such parallels have generated significant interest in understanding the shared vulnerabilities and trajectories between addiction and obesity. Now, brain imaging discoveries have started to uncover common features between these two conditions and to delineate some of the overlapping brain circuits whose dysfunctions may explain stereotypic and related behavioral deficits in human subjects. These results suggest that both obese and drug addicted individuals suffer from impairments in dopaminergic pathways that regulate neuronal systems associated not only with reward sensitivity and incentive motivation, but also with conditioning (memory/learning), impulse control (behavioral inhibition), stress reactivity and interoceptive awareness. Here, we integrate findings predominantly derived from positron emission tomography that investigate the role of dopamine in drug addiction and in obesity and propose an updated working model to help identify treatment strategies that may benefit both of these conditions.

Volkow N. D.; Wang G.; Volkow, N.D.; Wang, G.-J.; Fowler, J.S.; Tomasi, D.; Baler, R.

2012-12-01T23:59:59.000Z

499

Drug Innovation "Bridging Molecules and Diseases"  

E-Print Network [OSTI]

in the pharmaceutical industry. This focus area wishes to provide a knowledge and expertise platform, which platforms with the pharmaceutical industry are presently organized at three different levels: - Strategic, that allows high-level concerted drug research efforts in the molecular sciences, pharmaceutical sciences

Utrecht, Universiteit

500

Drug smuggling safety tests [July 1, 2006  

E-Print Network [OSTI]

enough to be utilized as drug carriers. Suslick adds that the three tests on mammalian cells they carried evidence of nano safety Login | Register Search: Site X-Ray Page 1 of 2X-Ray - Your Guide to All the Key X About Us | Contact Us | Privacy Policy | Terms & Conditions | Advertising | RSS Interested

Suslick, Kenneth S.