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Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Iontophoretic drug delivery system: A review  

Science Journals Connector (OSTI)

Among the recent developments in the field of transdermal drug delivery, iontophoresis has emerged as a very promising tool for this purpose. Various studies have been performed on drug delivery through the skin using electric current. Iontophoresis ... Keywords: Iontophoresis, iontophoretic systems, transdermal drug delivery

Ajay Semalty; Mona Semalty; Ranjit Singh; Shailendra K. Saraf; Shubhini Saraf

2007-09-01T23:59:59.000Z

2

Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System  

E-Print Network [OSTI]

Hydrophobic drug paclitaxel nanoparticles (PAX NPs) and pH sensitive hydrogels were prepared in this study to build a colon targeting nanoparticle based drug delivery system for oral administration. Negative charged PAX NPs at the size of 110...

Yu, Xiao

2012-07-16T23:59:59.000Z

3

An emerging platform for drug delivery: Aerogel based systems  

Science Journals Connector (OSTI)

Abstract Over the past few decades, advances in “aerogel science” have provoked an increasing interest for these materials in pharmaceutical sciences for drug delivery applications. Because of their high surface areas, high porosities and open pore structures which can be tuned and controlled by manipulation of synthesis conditions, nanostructured aerogels represent a promising class of materials for delivery of various drugs as well as enzymes and proteins. Along with biocompatible inorganic aerogels and biodegradable organic aerogels, more complex systems such as surface functionalized aerogels, composite aerogels and layered aerogels have also been under development and possess huge potential. Emphasis is given to the details of the aerogel synthesis and drug loading methods as well as the influence of synthesis parameters and loading methods on the adsorption and release of the drugs. Owing to their ability to increase the bioavailability of low solubility drugs, to improve both their stability and their release kinetics, there are an increasing number of research articles concerning aerogels in different drug delivery applications. This review presents an up to date overview of the advances in all kinds of aerogel based drug delivery systems which are currently under investigation.

Zeynep Ulker; Can Erkey

2014-01-01T23:59:59.000Z

4

Protein-Based Nanomedicine Platforms for Drug Delivery. | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Protein-Based Nanomedicine Platforms for Drug Delivery. Protein-Based Nanomedicine Platforms for Drug Delivery. Abstract: Drug delivery systems have been developed for many years,...

5

A Carbohydrate Recognition–Based Drug Delivery and Controlled Release System using Intraperitoneal Macrophages as a Cellular Vehicle  

Science Journals Connector (OSTI)

...fluorescence imaging system (FIS) with excitation...nm). For the detection of macrophages...for a cellular vehicle in a drug delivery system so as to control...controlled release system using intraperitoneal...as a cellular vehicle. | The lymphoid...

Yuzuru Ikehara; Toru Niwa; Le Biao; Sanae Kabata Ikehara; Norifumi Ohashi; Takeshi Kobayashi; Yoshitaka Shimizu; Naoya Kojima; and Hayao Nakanishi

2006-09-01T23:59:59.000Z

6

Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs  

E-Print Network [OSTI]

Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

Stauber, Zachary Jason

2012-01-01T23:59:59.000Z

7

Protein-Based Nanomedicine Platforms for Drug Delivery  

SciTech Connect (OSTI)

Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drug’s efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein based drug delivery system.

Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

2009-08-03T23:59:59.000Z

8

Novel drug delivery systems: Chitosan conjugates covalently attached to steroids with potential anticancer and agrochemical activity  

Science Journals Connector (OSTI)

Chitosan (CS) was linked to diosgenin monoesters with potential anticancer and agrochemical activity employing several methods (i.e. solid phase microwave assisted synthesis with carbodiimides activation, acyl chloride approach and homogeneous reaction with carbodiimides activation in aqueous solution). The steroid contents found by elemental analysis were between 5 and 33% (w/w) and was dependent on the nature of the employed linker and the steroid–CS conjugates preparation method. Linking was confirmed by FTIR spectroscopy. Differential scanning calorimetry studies are presented. In vitro release studies performed in water at different pH indicated a drug release dependence on the dicarboxylic acid employed as linker, the steroid content and the acidity of the solution. The obtained conjugates can be potentially applied as films, microspheres or gels for delivery of plant growth regulators in agriculture and anticancer drugs.

Javier Pérez Quiñones; Richard Szopko; Claudia Schmidt; Carlos Peniche Covas

2011-01-01T23:59:59.000Z

9

Needle-free drug delivery using shock wave techniques  

E-Print Network [OSTI]

A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

Pavlov, Atanas (Atanas Ivanov)

2006-01-01T23:59:59.000Z

10

Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery  

E-Print Network [OSTI]

The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

Tan, Mei Chee

11

Apoferritin-based nanomedicine platform for drug delivery: equilibrium...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA. Apoferritin-based nanomedicine platform for drug delivery: equilibrium...

12

Evaluation of Dysprosia Aerogels as Drug Delivery Systems: A Comparative Study with Random and Ordered Mesoporous Silicas  

Science Journals Connector (OSTI)

The high drug uptake and slow release from dysprosia aerogels, in combination with their low toxicity, strong paramagnetism, and the possibility for neutron activation render those materials attractive multifunctional vehicles for site-specific drug delivery. ... X-rdm-DyOx aerogel samples (1 mg) were incubated with fresh human whole blood (30 ?L, Oklahoma Blood Institute, Oklahoma City, OK) for 24 h at room temperature. ...

Abhishek Bang; Anand G. Sadekar; Clayton Buback; Brice Curtin; Selin Acar; Damir Kolasinac; Wei Yin; David A. Rubenstein; Hongbing Lu; Nicholas Leventis; Chariklia Sotiriou-Leventis

2014-03-25T23:59:59.000Z

13

Optimal periodic control of a drug delivery system Subbarao Varigonda 1  

E-Print Network [OSTI]

drug infusion strategies for maximizing a time averaged measure of drug effect are investigated infusion provides a locally improved average effect compared to steady infusion are characterized using 1­2 hr), as steady infusion leads to nearly complete sup- pression of gonadal function [24

Georgiou, Tryphon T.

14

Non-metallic nanomaterials in cancer theranostics: a review of silica- and carbon-based drug delivery systems  

Science Journals Connector (OSTI)

The rapid development in nanomaterials has brought great opportunities to cancer theranostics, which aims to combine diagnostics and therapy for cancer treatment and thereby improve the healthcare of patients. In this review we focus on the recent progress of several cancer theranostic strategies using mesoporous silica nanoparticles and carbon-based nanomaterials. Silicon and carbon are both group IV elements; they have been the most abundant and significant non-metallic substances in human life. Their intrinsic physical/chemical properties are of critical importance in the fabrication of multifunctional drug delivery systems. Responsive nanocarriers constructed using these nanomaterials have been promising in cancer-specific theranostics during the past decade. In all cases, either a controlled texture or the chemical functionalization is coupled with adaptive properties, such as pH-, light-, redox- and magnetic field- triggered responses. Several studies in cells and mice models have implied their underlying therapeutic efficacy; however, detailed and long-term in vivo clinical evaluations are certainly required to make these bench-made materials compatible in real bedside circumstances.

Yu-Cheng Chen; Xin-Chun Huang; Yun-Ling Luo; Yung-Chen Chang; You-Zung Hsieh; Hsin-Yun Hsu

2013-01-01T23:59:59.000Z

15

Mucoadhesive Sustained Drug Delivery System Based on Cationic Polymer and Anionic Cyclodextrin/Triclosan Complex  

Science Journals Connector (OSTI)

In this study the interactions between a cationic polymer and an anionic cyclodextrin were investigated. The system has the potential for use in a sustained release dosage forms for use on mucous membranes. As mu...

Hakon H. Sigurdsson; Elin Knudsen…

2002-12-01T23:59:59.000Z

16

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network [OSTI]

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

17

Novel Polysaccharide Based Polymers and Nanoparticles for Controlled Drug Delivery and Biomedical Imaging.  

E-Print Network [OSTI]

??The use of polysaccharides as building blocks in the development of drugs and contrast agents delivery systems is rapidly growing. This can be attributed to… (more)

Shalviri, Alireza

2013-01-01T23:59:59.000Z

18

Hydrogen Delivery Technologies and Systems - Pipeline Transmission...  

Broader source: Energy.gov (indexed) [DOE]

Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen Hydrogen Delivery...

19

Controlling drug delivery across the placenta: A commentary  

E-Print Network [OSTI]

A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ...

Audus, Kenneth L.

1999-01-01T23:59:59.000Z

20

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network [OSTI]

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Nano compartments may aid drug delivery, catalyst design > Archived...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nano compartments may aid drug delivery, catalyst design April 18th, 2013 By Bill Steele Spongelike nanoparticles whose pores can be filled with drugs offer the promise of drug...

22

Energy Delivery Systems Cybersecurity | Department of Energy  

Office of Environmental Management (EM)

Services Cybersecurity Energy Delivery Systems Cybersecurity Energy Delivery Systems Cybersecurity About the Cybersecurity for Energy Delivery Systems Program A key mission...

23

Energy Delivery Systems Cybersecurity | Department of Energy  

Energy Savers [EERE]

Cybersecurity Energy Delivery Systems Cybersecurity Energy Delivery Systems Cybersecurity About the Cybersecurity for Energy Delivery Systems Program A key mission of the...

24

Thermo-responsive Layer-by-Layer Assemblies for Nanoparticle-based Drug Delivery  

E-Print Network [OSTI]

release in response to temperature is still challenging. Here, a thermo-responsive drug delivery system of solid dexamethasone nanoparticles (DXM NPs) encapsulated in a model LbL assembly of strong polyelectrolytes poly (diallyldimethylammonium chloride...

Zhou, Jing

2013-11-26T23:59:59.000Z

25

Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device  

E-Print Network [OSTI]

The goal of this thesis was to advance an implantable drug delivery MEMS (MicroElectroMechanical Systems) device developed in our laboratory. This device was designed to locally deliver multiple substances in complex release ...

Li, Yawen, 1972-

2005-01-01T23:59:59.000Z

26

E-Print Network 3.0 - active drug delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug Delivery, Bionanotechnology and Molecular Recognition, Departments... 78712, USA Recent advances in the discovery and delivery of drugs to cure chronic diseases are...

27

Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery  

Science Journals Connector (OSTI)

Abstract Considerable effort has been directed towards developing novel drug delivery systems. Microfluidics, capable of generating monodisperse single and multiple emulsion droplets, executing precise control and operations on these droplets, is a powerful tool for fabricating complex systems (microparticles, microcapsules, microgels) with uniform size, narrow size distribution and desired properties, which have great potential in drug delivery applications. This review presents an overview of the state-of-the-art multiphase flow microfluidics for the production of single emulsions or multiple emulsions for drug delivery. The review starts with a brief introduction of the approaches for making single and multiple emulsions, followed by presentation of some potential drug delivery systems (microparticles, microcapsules and microgels) fabricated in microfluidic devices using single or multiple emulsions as templates. The design principles, manufacturing processes and properties of these drug delivery systems are also discussed and compared. Furthermore, drug encapsulation and drug release (including passive and active controlled release) are provided and compared highlighting some key findings and insights. Finally, site-targeting delivery using multiphase flow microfluidics is also briefly introduced.

Chun-Xia Zhao

2013-01-01T23:59:59.000Z

28

Local drug delivery for enhancing fracture healing in osteoporotic bone  

Science Journals Connector (OSTI)

Abstract Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an osteoporotic fracture is challenging due to the decreased strength of the surrounding bone and suboptimal healing capacity, predisposing both to fixation failure and non-union. Whereas a systemic osteoporosis treatment acts slowly, local release of osteogenic agents in osteoporotic fracture would act rapidly to increase bone strength and quality, as well as to reduce the bone healing period and prevent development of a problematic non-union. The identification of agents with potential to stimulate bone formation and improve implant fixation strength in osteoporotic bone has raised hope for the fast augmentation of osteoporotic fractures. Stimulation of bone formation by local delivery of growth factors is an approach already in clinical use for the treatment of non-unions, and could be utilized for osteoporotic fractures as well. Small molecules have also gained ground as stable and inexpensive compounds to enhance bone formation and tackle osteoporosis. The aim of this paper is to present the state of the art on local drug delivery in osteoporotic fractures. Advantages, disadvantages and underlying molecular mechanisms of different active species for local bone healing in osteoporotic bone are discussed. This review also identifies promising new candidate molecules and innovative approaches for the local drug delivery in osteoporotic bone.

Laura Kyllönen; Matteo D’Este; Mauro Alini; David Eglin

2014-01-01T23:59:59.000Z

29

A review of age-old antimalarial drug to combat malaria: efficacy up-gradation by nanotechnology based drug delivery  

Science Journals Connector (OSTI)

Abstract Malaria is uncontrolled burden in the world till now. Despite of different efforts to develop antimalarial drug for decades, any anti-malarial drug can able to eradicate completely till now. Many anti-malarial substances are practically ineffectual because of their physicochemical limitations, cytotoxicity, chemical instability and degradation, and limited activities against intracellular parasites. Taking into consideration, the amount of research is going to conduct in the field of nanoparticle based drug delivery systems, lead to new ways of improving the treatment of infectious diseases. The study has focused on the progress and advancement of research on nanotechnology based drug delivery to eradicate the malaria. We like to focus the efficacy of nanotechnology based drug application for the opening out of novel chemotherapeutics in laboratory research, which may show the way to better use with age-old antimalarial drug and may draw the attention of pharmaceutical industries for the improvement and designing of effective anti-malarial drugs in future.

Satyajit Tripathy; Somenath Roy

2014-01-01T23:59:59.000Z

30

Radiation delivery system and method  

DOE Patents [OSTI]

A radiation delivery system and method are described. The system includes a treatment configuration such as a stent, balloon catheter, wire, ribbon, or the like, a portion of which is covered with a gold layer. Chemisorbed to the gold layer is a radiation-emitting self-assembled monolayer or a radiation-emitting polymer. The radiation delivery system is compatible with medical catheter-based technologies to provide a therapeutic dose of radiation to a lesion following an angioplasty procedure.

Sorensen, Scott A. (Overland Park, KS); Robison, Thomas W. (Los Alamos, NM); Taylor, Craig M. V. (Jemez Springs, NM)

2002-01-01T23:59:59.000Z

31

Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance  

E-Print Network [OSTI]

period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

Clairambault, Jean

32

Nanomedicine for Cancer: Lipid-Based Nanostructures for Drug Delivery and Monitoring  

Science Journals Connector (OSTI)

Nanomedicine for Cancer: Lipid-Based Nanostructures for Drug Delivery and Monitoring ... Lipid-Based Nanomedicines for Cancer ...

Yoshihisa Namiki; Teruaki Fuchigami; Norio Tada; Ryo Kawamura; Satoshi Matsunuma; Yoshitaka Kitamoto; Masaru Nakagawa

2011-07-26T23:59:59.000Z

33

Abstract #1561: RNA nanoparticle vaccines: combining drug inducible CD40 activation with CTL peptide delivery improves vaccine efficacy  

Science Journals Connector (OSTI)

...Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc...circulation. We have engineered a polymeric nanoparticle encapsulated curcumin formulation...bioavailability. We envisioned that nanoparticle-mediated drug delivery could be useful...

Alison McCormick; Jan Kemnade; David Spencer

2009-05-01T23:59:59.000Z

34

In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities  

Science Journals Connector (OSTI)

...delivery of poorly water-soluble (hydrophobic...considered poorly water-soluble, using...Classification System for drug solubility (1). The conventional...prototype for a poorly water-soluble, hydrophobic...an initiator in a nitrogen (N2) atmosphere...passing nitrogen gas for 30 min. Thereafter...

Savita Bisht; Georg Feldmann; Jan-Bart M. Koorstra; Michael Mullendore; Hector Alvarez; Collins Karikari; Michelle A. Rudek; Carlton K. Lee; Amarnath Maitra; and Anirban Maitra

2008-12-01T23:59:59.000Z

35

Synthetic LDL as targeted drug delivery vehicle  

DOE Patents [OSTI]

The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

2012-08-28T23:59:59.000Z

36

A nano-immunoassay system for monitoring targeted drug impact on signaling pathways from small samples of primary hematopoietic malignancies  

Science Journals Connector (OSTI)

...An evaluation of the role of Mucin in nano drug delivery. Musaed Allkholief Robert...determine the role of mucin in the delivery of nano-sized drug delivery systems. Methods...An evaluation of the role of Mucin in nano drug delivery. [abstract]. In: Proceedings...

Alice Fan; Wilhelm Lachnit; Debabrita Deb-Basu; David Voehringer; Dean Felsher

2007-11-15T23:59:59.000Z

37

Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors  

Science Journals Connector (OSTI)

...mum of tissue, using a 543 excitation laser and LP 560 emission filter. A plane approximately...to local tumors can be thought of as the fusion of 2 traditional approaches to drug delivery...Ther 2010;9:1798-808. 11. Dvorak HF , Nagy JA, Dvorak JT Dvorak AM.Identification...

Ashley A. Manzoor; Lars H. Lindner; Chelsea D. Landon; Ji-Young Park; Andrew J. Simnick; Matthew R. Dreher; Shiva Das; Gabi Hanna; Won Park; Ashutosh Chilkoti; Gerben A. Koning; Timo L.M. ten Hagen; David Needham; and Mark W. Dewhirst

2012-11-01T23:59:59.000Z

38

E-Print Network 3.0 - advanced drug delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Nano-scale Delivery: Impact on Absorption and Nicholas A. Peppas Summary: 78712, USA Recent advances in the discovery and delivery of drugs to cure chronic diseases are...

39

Hydrogen Delivery Technologies and Systems - Pipeline Transmission...  

Broader source: Energy.gov (indexed) [DOE]

Technologies and Systems Pipeline Transmission of Hydrogen Strategic Initiatives for Hydrogen Delivery Workshop May 7- 8, 2003 U.S. Department of Energy Hydrogen, Fuel Cells,...

40

Multiscale modeling and uncertainty quantification in nanoparticle-mediated drug/gene delivery  

Science Journals Connector (OSTI)

Nanoparticle (NP)-mediated drug/gene delivery involves phenomena at broad range spatial and temporal scales. The interplay between these phenomena makes the NP-mediated drug/gene delivery process very complex. In this paper, we have identified four key ... Keywords: Coarse-grained molecular dynamics, Drug delivery, Fluid-structure interaction, Immersed molecular electrokinetic finite element, Molecular mean-field theory, Multiscale modeling

Ying Li, Wylie Stroberg, Tae-Rin Lee, Han Sung Kim, Han Man, Dean Ho, Paolo Decuzzi, Wing Kam Liu

2014-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.  

E-Print Network [OSTI]

?? The purpose of this study was to design, synthesize and develop novel transporter targeting agents for image-guided therapy and drug delivery. Two novel agents,… (more)

Tsao, Ning

2013-01-01T23:59:59.000Z

42

Fiber coupled optical spark delivery system  

DOE Patents [OSTI]

A spark delivery system for generating a spark using a laser beam is provided, the spark delivery system including a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. In addition, the laser delivery assembly includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. In accordance with embodiments of the present invention, the assembly may be used to create a spark in a combustion engine. In accordance with other embodiments of the present invention, a method of using the spark delivery system is provided. In addition, a method of choosing an appropriate fiber for creating a spark using a laser beam is also presented.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO)

2008-08-12T23:59:59.000Z

43

The dual-piston jet injector and the viability of drug delivery  

E-Print Network [OSTI]

Drug delivery through jet-injection opens the doors to very rapid drug dispersion by eliminating the need for needle sterilization. With this comes the need for a continuous flow of fluids from a large reservoir, currently ...

Cunningham, Daniel (Daniel P.)

2007-01-01T23:59:59.000Z

44

Preparation of ?-Fe2O3/SiO2-capsule composites capable of using as drug delivery and magnetic targeting system from hydrophobic iron acetylacetonate and hydrophilic SiO2-capsule  

Science Journals Connector (OSTI)

Abstract Series of nanocomposites with ?-Fe2O3 supported on SiO2-capsules were prepared by adsorption of hydrophobic iron acetylacetonate on the hydrophilic surface of SiO2-capsules in the evaporation process of the solvent and then calcination the complex at 450 °C. The adsorption and calcination conditions were studied and the resultant nanaoparticles were characterized by XRD, XRF and TEM in detail. The results indicated that ?-Fe2O3 loaded discontinuously but uniformly on the surface of SiO2-capsules at appropriate content. The specific surface area characterization and doxorubicin hydrochloride release shown although the surface area of the target composites decreased slightly, the nanoparticles still had large potential using as drug delivery and magnetic targeting system.

Fengzhu Lv; Liling Fu; Emmanuel P. Giannelis; Genggeng Qi

2014-01-01T23:59:59.000Z

45

Towards engineering hormone-binding globulins as drug delivery agents  

E-Print Network [OSTI]

directly for destruction by the body’s immune system. There are currently three antibody-drug conjugates and 11 ‘naked’ monoclonal antibodies approved by the Food and Drug Administration for the treatment of cancers [9, 10]. Another form of immunotherapy... efficacy in many cases [50]. Currently, the most common chemotherapeutic treatment for malignant metastatic prostate cancer is docetaxel, a mitotic poison [51]. In the next part of this proof-of-concept experiment, we sought to show that it is possible...

Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

2014-11-26T23:59:59.000Z

46

Fiber laser coupled optical spark delivery system  

DOE Patents [OSTI]

A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

2008-03-04T23:59:59.000Z

47

Development of a polylactic acid (PLA) polymer with an acid-sensitive N-ethoxybenzylimidazole (NEBI) crosslinker as a drug delivery system  

E-Print Network [OSTI]

DiamondTM (Barnstead) water purification system before useDiamond TM (Barnstead) water purification system before useDiamond TM (Barnstead) water purification system before use

Hang, Leibniz Fangtinq

2012-01-01T23:59:59.000Z

48

Development of a polylactic acid (PLA) polymer with an acid-sensitive N-ethoxybenzylimidazole (NEBI) crosslinker as a drug delivery system  

E-Print Network [OSTI]

DiamondTM (Barnstead) water purification system before useTM (Barnstead) water purification system before use inTM (Barnstead) water purification system before use in

Hang, Leibniz Fangtinq

2012-01-01T23:59:59.000Z

49

Self-Assembling Doxorubicin–Tocopherol Succinate Prodrug as a New Drug Delivery System: Synthesis, Characterization, and in Vitro and in Vivo Anticancer Activity  

Science Journals Connector (OSTI)

Gong, X., Moghaddam, M. J., Sagnella, S. M., Conn, C. E., Danon, S. J., Waddington, L. J., and Drummond, C. J. ( 2011) Lyotropic liquid crystalline self-assembly material behavior and nanoparticulate dispersions of a phytanyl pro-drug analogue of capecitabine-a chemotherapy agent ACS Appl. ... Gong, Xiaojuan; Moghaddam, Minoo J.; Sagnella, Sharon M.; Conn, Charlotte E.; Danon, Stephen J.; Waddington, Lynne J.; Drummond, Calum J. ...

Nicolas Duhem; Fabienne Danhier; Vincent Pourcelle; Jean-Marc Schumers; Olivier Bertrand; Cécile S. LeDuff; Stephanie Hoeppener; Ulrich S. Schubert; Jean-François Gohy; Jacqueline Marchand-Brynaert; Véronique Préat

2013-12-11T23:59:59.000Z

50

Nanomedicine: making controllable magnetic drug delivery possible for the treatment of breast cancer  

Science Journals Connector (OSTI)

A recent study published in Nano Letters documents the synthesis and performance of porous silica nanocapsules filled with magnetic nanoparticles as a controllable magnetic drug delivery vector. Under a remotely ...

Lesa A Tran; Lon J Wilson

2011-03-01T23:59:59.000Z

51

Amphiphilic gold nanoparticles: mechanisms for interaction with membranes and applications in drug and vaccine delivery  

E-Print Network [OSTI]

Materials that can interact with and transit membranes without toxic bilayer disruption or poration are of great interest in the drug delivery field. These materials can presumably bypass endocytosis to directly enter the ...

Atukorale, Prabhani U. (Prabhani Upeka)

2014-01-01T23:59:59.000Z

52

Enhancing pharmaceutical formulations to improve efficacy and delivery of drug molecules  

E-Print Network [OSTI]

Major impediments to the full utility of current and potential drugs include issues of resistance and delivery. To address these challenges, in this thesis two directions of research were pursued: (1) the use of multivalent ...

Weight, Alisha K. (Alisha Kessel)

2013-01-01T23:59:59.000Z

53

Abstract LB-9: Light-controllable nano-drug delivery system with deep tissue penetrating ability for cancer therapy with two-photon-triggered nanoimpellers  

Science Journals Connector (OSTI)

...imaging for the breast cancer: Effect of nano-particle size and potential of therapeutic...In order to investigate the kinetics of nano-size molecules in the lymphatic system...diameter from 3 to 12 nm using dendrimer nano-technology were synthesized. A semi-quantitative...

Jie lu; Jonas Croissant; Jean-Olivier Jean-Olivier Durand; Tania Guardado-Alvarez; Jeffrey I. Zink; Fuyuhiko Tamanoi

2014-10-01T23:59:59.000Z

54

Toward a drug delivery coating for intraocular lenses  

E-Print Network [OSTI]

Layer-by-layer assembly has become a quintessential tool for the creation of versatile, dynamic nanostructured materials able to dictate cellular behavior through exquisite surface functionality and delivery of bioactive ...

Smith, Renée Chivon

2010-01-01T23:59:59.000Z

55

Waste Feed Delivery Transfer System Analysis  

SciTech Connect (OSTI)

This document provides a documented basis for the required design pressure rating and pump pressure capacity of the Hanford Site waste-transfer system in support of the waste feed delivery to the privatization contractor for vitrification. The scope of the analysis includes the 200 East Area double-shell tank waste transfer pipeline system and the associated transfer system pumps for a11 Phase 1B and Phase 2 waste transfers from AN, AP, AW, AY, and A2 Tank Farms.

JULYK, L.J.

2000-05-05T23:59:59.000Z

56

Hg Delivery System Vacuum 25 Oct 2005  

E-Print Network [OSTI]

. S. DEPARTMENT OF ENERGY V. Graves 25 Oct 2005 MERIT Mtg at MIT Oct 17-19 · During Hg delivery system to both design and operations #12;3 OAK RIDGE NATIONAL LABORATORY U. S. DEPARTMENT OF ENERGY V. Graves 25 & return lines - Sump tank & all connecting ports - Hg cylinder & bellows Hg inlet Hg cylinder & Bellows

McDonald, Kirk

57

Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection  

SciTech Connect (OSTI)

The central theme of this dissertation is represented by the versatility of mesoporous silica nanomaterials in various applications such as catalysis and bio-applications, with main focus on biological applications of Mesoporous Silica Nanospheres (MSN). The metamorphosis that we impose to these materials from catalysis to sensing and to drug and gene delivery is detailed in this dissertation. First, we developed a synthetic method that can fine tune the amount of chemically accessible organic functional groups on the pores surface of MSN by exploiting electrostatic and size matching between the cationic alkylammonium head group of the cetyltrimethylammonium bromide (CTAB) surfactant and various anionic organoalkoxysilane precursors at the micelle-water interface in a base-catalyzed condensation reaction of silicate. Aiming nature imitation, we demonstrated the catalytic abilities of the MSNs, We utilized an ethylenediamine functional group for chelating Cu{sup 2+} as a catalytic functional group anchored inside the mesopores. Thus, a polyalkynylene-based conducting polymer (molecular wire) was synthesized within the Cu-functionalized MSNs silica catalyst. For sensing applications, we have synthesized a poly(lactic acid) coated mesoporous silica nanosphere (PLA-MSN) material that serves as a fluorescence sensor system for detection of amino-containing neurotransmitters in neutral aqueous buffer. We exploited the mesoporosity of MSNs for encapsulating pharmaceutical drugs. We examined bio-friendly capping molecules such as polyamidoamine dendrimers of generations G2 to G4, to prevent the drug leaching. Next, the drug delivery system employed MSNs loaded with Doxorubicin, an anticancer drug. The results demonstrated that these nano-Trojan horses have ability to deliver Doxorubicin to cancer cells and induce their death. Finally, to demonstrate the potential of MSN as an universal cellular transmembrane nanovehicle, we anchored positively charged dendrimers on the surface of MSN and utilize them to complex cationic DNA. The p-EGFP-CI gene-coated MSN nanocomposite was able to transfect cancer cell lines, such as human HeLa and CHO cancer cell lines. The gene carrier ability of MSNs was further proved by transfecting primary cells and cotransfecting of two different genes in cancer cell lines. In sum, MSN are versatile partners in several types of applications.

Daniela Rodica Radu

2005-12-19T23:59:59.000Z

58

Roadmap to Achieve Energy Delivery Systems Cybersecurity  

Broader source: Energy.gov (indexed) [DOE]

Roadmap to Achieve Energy Delivery Systems Cybersecurity Roadmap to Achieve Energy Delivery Systems Cybersecurity ii Acknowledgements The Energy Sector Control Systems Working Group (ESCSWG) developed this roadmap in support of the Electricity Sub-sector Coordinating Council, Oil and Natural Gas Sector Coordinating Council, and the Government Coordinating Council for Energy under the Critical Infrastructure Partnership Advisory Council (CIPAC) Framework; the roadmap has been approved for release by these councils. The ESCSWG members volunteered their time and expertise to this effort and would like to thank the other participants for their valuable perspectives and contributions to this important effort. Special thanks go to the U.S. Department of Energy, which provided the funds and support needed to convene participants

59

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Vulnerability and Intrusion Detection Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection National lab researchers,...

60

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications National lab researchers, industry partners, and academia...

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry...

62

Polysaccharide-based aerogel microspheres for oral drug delivery  

Science Journals Connector (OSTI)

Abstract Polysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides and the enhanced drug loading capacity of dry aerogels. Aerogel microspheres from starch, pectin and alginate were loaded with ketoprofen (anti-inflammatory drug) and benzoic acid (used in the management of urea cycle disorders) via supercritical CO2-assisted adsorption. Amount of drug loaded depended on the aerogel matrix structure and composition and reached values up to 1.0 × 10?3 and 1.7 × 10?3 g/m2 for ketoprofen and benzoic acid in starch microspheres. After impregnation, drugs were in the amorphous state in the aerogel microspheres. Release behavior was evaluated in different pH media (pH 1.2 and 6.8). Controlled drug release from pectin and alginate aerogel microspheres fitted Gallagher-Corrigan release model (R2 > 0.99 in both cases), with different relative contribution of erosion and diffusion mechanisms depending on the matrix composition. Release from starch aerogel microspheres was driven by dissolution, fitting the first-order kinetics due to the rigid starch aerogel structure, and showed different release rate constant (k1) depending on the drug (0.075 and 0.160 min?1 for ketoprofen and benzoic acid, respectively). Overall, the results point out the possibilities of tuning drug loading and release by carefully choosing the polysaccharide used to prepare the aerogels.

C.A. García-González; M. Jin; J. Gerth; C. Alvarez-Lorenzo; I. Smirnova

2014-01-01T23:59:59.000Z

63

Cybersecurity for Energy Delivery Systems (CEDS) Peer Review...  

Broader source: Energy.gov (indexed) [DOE]

Peer Review August 5-7 Cybersecurity for Energy Delivery Systems (CEDS) Peer Review August 5-7 June 26, 2014 - 1:03pm Addthis The Office of Electricity Delivery and Energy...

64

Vulnerability Analysis of Energy Delivery Control Systems  

Broader source: Energy.gov (indexed) [DOE]

0-18381 0-18381 Vulnerability Analysis of Energy Delivery Control Systems September 2011 Idaho National Laboratory Idaho Falls, Idaho 83415 http://www.inl.gov Prepared for the U.S. Department of Energy Office of Electricity Delivery and Energy Reliability Under DOE Idaho Operations Office Contract DE-AC07-05ID14517 The INL is a U.S. Department of Energy National Laboratory operated by Battelle Energy Alliance DISCLAIMER This information was prepared as an account of work sponsored by an agency of the U.S. Government. Neither the U.S. Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness, of any information, apparatus, product, or

65

Manganese-loaded lipid-micellar theranostics for simultaneous drug and gene delivery to lungs  

Science Journals Connector (OSTI)

Abstract Gadolinium (Gd) contrast agents are predominantly used for T1 MR imaging. However, the high toxicity of Gd3 + and potential side effects including nephrogenic systemic fibrosis have led to the search for alternative T1 contrast agents. Since manganese (Mn) has paramagnetic properties with five unpaired electrons that permit high spin number, long electronic relaxation times, and labile water exchange, we evaluated Mn as a T1 magnetic resonance imaging (MRI) contrast agent for lung imaging. Here we report on the design and synthesis of multifunctional lipid-micellar nanoparticles (LMNs) containing Mn oxide (M-LMNs) for MRI that can also be used for DNA and drug delivery. Oleic acid-coated MnO nanoparticles were encapsulated in micelles composed of polyethylene glycol (PEG-2000), phosphatidylethanolamine (PE), DC-cholesterol, and dioleoyl-phosphatidylethanolamine (DOPE). The particles are taken up in vitro by human embryonic kidney (HEK293), Lewis lung carcinoma (LLC1), and A549 cells and are devoid of cytotoxicity. When administered to mice intranasally, they preferentially accumulate in the lungs. In vitro phantom and ex vivo lung MRI results confirmed that M-LMNs are able to enhance T1 MRI contrast. M-LMNs loaded with plasmid DNA and/or doxorubicin are efficiently taken up by HEK293 cells in vitro and by target cells in vivo. Taken together, these results demonstrate that M-LMNs are capable of simultaneously providing MRI contrast and DNA and/or drug delivery to target cells in the lung and therefore may prove useful as a lung theranostic, especially for lung cancers.

M. Howell; J. Mallela; C. Wang; S. Ravi; S. Dixit; U. Garapati; S. Mohapatra

2013-01-01T23:59:59.000Z

66

CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery with comparisons to in vitro data  

E-Print Network [OSTI]

CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery t Enhanced condensational growth (ECG) is a newly proposed concept for respiratory drug delivery in which and evaluate a CFD model of ECG in a simple tubular geometry with direct comparisons to in vitro results

Frey, Pascal

67

A PARYLENE BELLOWS ELECTROCHEMICAL ACTUATOR FOR INTRAOCULAR DRUG DELIVERY  

E-Print Network [OSTI]

Implant INTRODUCTION Water electrolysis using coplanar microelectrodes offers a promising pumping with the contents of the drug reservoir. Electrolysis-induced gas generation (phase change of water into hydrogen) water and then joined together (Figure 2). Electrolysis pumping is selected over other actuation methods

Meng, Ellis

68

Cybersecurity for Energy Delivery Systems 2010 Peer Review | Department of  

Broader source: Energy.gov (indexed) [DOE]

Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. The final agenda and welcome presentation are below. Presentations

69

Cybersecurity for Energy Delivery Systems 2010 Peer Review | Department of  

Broader source: Energy.gov (indexed) [DOE]

Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. The final agenda and welcome presentation are below. Presentations

70

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Infrastructure for the Power Grid (TCIPG) Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the Power Grid (TCIPG)...

71

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Practice DesignConfiguration Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practice DesignConfiguration National lab researchers, industry...

72

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Visualization and Modeling Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Visualization and Modeling National lab researchers, industry partners, and...

73

Hydrogen Delivery Technologies and Systems- Pipeline Transmission of Hydrogen  

Broader source: Energy.gov [DOE]

Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen. Design and operations standards and materials for hydrogen and natural gas pipelines.

74

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Software Engineering Institute Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations from Carnegie Mellon University's Software Engineering

75

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Visualization and Modeling Visualization and Modeling Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Visualization and Modeling National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Visualization and Modeling are below.

76

Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 |  

Broader source: Energy.gov (indexed) [DOE]

Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 As part of the Obama Administration's goals to enhance the security and reliability of the Nation's energy infrastructure, the U.S. Department of Energy released the 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity. Developed as an update to the 2006 Roadmap to Secure Control Systems in the Energy Sector, the report outlines a strategic framework over the next decade among industry, vendors, academia and government stakeholders to design, install, operate, and maintain a resilient energy delivery system capable of surviving a cyber incident while sustaining critical functions. Developed by the Energy Sector Control Systems Working Group, a partnership

77

Vulnerability Analysis of Energy Delivery Control Systems - 2011 |  

Broader source: Energy.gov (indexed) [DOE]

Vulnerability Analysis of Energy Delivery Control Systems - 2011 Vulnerability Analysis of Energy Delivery Control Systems - 2011 Vulnerability Analysis of Energy Delivery Control Systems - 2011 Cybersecurity for energy delivery systems has emerged as one of the Nation's most serious grid modernization and infrastructure protection issues. Cyber adversaries are becoming increasingly targeted, sophisticated, and better financed. The energy sector must research, develop and deploy new cybersecurity capabilities faster than the adversary can launch new attack tools and techniques. The goal of the U.S. Department of Energy Office of Electricity Delivery and Energy Reliability (DOE/OE) National Supervisory Control and Data Acquisition (SCADA) Test Bed (NSTB) program is to enhance the reliability and resiliency of the Nation's energy infrastructure by reducing the risk

78

A simulation study for a coal delivery system  

Science Journals Connector (OSTI)

This paper discusses a computer simulation model that was constructed to assist in evaluating alternatives for a coal delivery system. A complex system, involving unit trains, intermediate storage, transshipment and lake vessels is required to transport ...

T. C. Vorce

1982-03-01T23:59:59.000Z

79

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

80

Optical diagnostics integrated with laser spark delivery system  

DOE Patents [OSTI]

A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

2008-09-02T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats  

Science Journals Connector (OSTI)

...convection-enhanced drug delivery study in rats Liat Goldberg 1 Aharon Ocherashvilli 2...of the Ras oncogene in a 9L gliosarcoma rat model. The drug we used was salirasib...tumor growth rate in salirasib-treated rats relative to vehicle-treated rats as well...

Liat Goldberg; Aharon Ocherashvilli; Dianne Daniels; David Last; Zvi R. Cohen; Gregory Tamar; Yoel Kloog; Yael Mardor

2008-11-01T23:59:59.000Z

82

Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth  

E-Print Network [OSTI]

Assembly of functional nanocomponents offers promising applications in drug delivery to solid tumors and bottom-up synthesis and integration of nanodevices. This thesis presents a novel multistage nanoparticle delivery ...

Wong, Cliff R. (Cliff Richard)

2011-01-01T23:59:59.000Z

83

Delivery system for molten salt oxidation of solid waste  

DOE Patents [OSTI]

The present invention is a delivery system for safety injecting solid waste particles, including mixed wastes, into a molten salt bath for destruction by the process of molten salt oxidation. The delivery system includes a feeder system and an injector that allow the solid waste stream to be accurately metered, evenly dispersed in the oxidant gas, and maintained at a temperature below incineration temperature while entering the molten salt reactor.

Brummond, William A. (Livermore, CA); Squire, Dwight V. (Livermore, CA); Robinson, Jeffrey A. (Manteca, CA); House, Palmer A. (Walnut Creek, CA)

2002-01-01T23:59:59.000Z

84

Synthetic Nano-Low Density Lipoprotein as Targeted Drug DeliveryVehicle for Glioblastoma Multiforme  

SciTech Connect (OSTI)

This paper discribes a synthetic low density lipoprotein(LDL) made by complexing a 29 amino acid that consists of a lipid bindingdomain and the LDL receptor binding domain with a lipid microemulsion.The nano-LDL particles were intermdiate in size between LDL and HDL andbound to LDL receptors on GBM brain tumor cells. Synthetic nano-LDLuptake by GBM cells was LDL receptor specific and dependent on cellreceptor number. It is suggested that these synthetic particles can serveas a delivery vehicle for hydophobic anti-tumor drugs by targeting theLDL receptor.

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu,Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-06-14T23:59:59.000Z

85

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs.

86

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Secure Communications Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Secure Communications are below. CEDS 2010 Peer Review - Cryptographic Trust Management - Mark Hadley,

87

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Vulnerability and Intrusion Detection Vulnerability and Intrusion Detection Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Vulnerability and Instrusion Detection are below.

88

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Vulnerability and Intrusion Detection Vulnerability and Intrusion Detection Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Vulnerability and Instrusion Detection are below.

89

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Best Practices/Standards Development Best Practices/Standards Development Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practices/Standards Development National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Best Practices/Standards Development are below.

90

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Practice Design/Configuration Practice Design/Configuration Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practice Design/Configuration National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Best Practice Design/Configuration are below.

91

Synthesis, Processing and Solid State Excipient Interactions of Cucurbit[6]uril and Its Formulation into Tablets for Oral Drug Delivery  

Science Journals Connector (OSTI)

(15) Previously, CB[n]s have been shown to be excellent drug delivery vehicles for platinum-based anticancer drugs,(5, 16, 17) agricultural fungicides,(18) acetylchloinesterase inhibitors and cholines,(19, 20) antituberculosis drugs,(21) and anesthetics,(22) and as physical stabilizers for a range of other drugs, such as memantine, atenolol, glibenclamide and paracetamol. ... Simulated intestinal fluid (SIFsp) was made in accordance with the United States Pharmacopeia using 6.8 g of KH2PO4 and 0.89 g of NaOH in 1.0 L of water to obtain a buffer of pH 6.8. ...

Shonagh Walker; Rajdip Kaur; Fiona J. McInnes; Nial J. Wheate

2010-07-16T23:59:59.000Z

92

Tank Waste Feed Delivery System Readiness at the Hanford Site  

Broader source: Energy.gov (indexed) [DOE]

Audit Report Audit Report Tank Waste Feed Delivery System Readiness at the Hanford Site OAS-L-12-09 August 2012 Department of Energy Washington, DC 20585 August 23, 2012 MEMORANDUM FOR THE MANAGER, OFFICE OF RIVER PROTECTION FROM: David Sedillo, Director Western Audits Division Office of Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Tank Waste Feed Delivery System Readiness at the Hanford Site" BACKGROUND The Department of Energy's largest cleanup task involves the treatment, immobilization and disposal of 56 million gallons of hazardous and highly radioactive waste at the Hanford Site, located in Southeastern Washington State. As part of this effort, the Department is constructing

93

Clinical Delivery System for Intraperitoneal Hyperthermic Chemotherapy  

Science Journals Connector (OSTI)

...through a sequential dual-filter system and a subsequent warming coil...The sequential dual-filter system is composed of a 4O-@smPall...and outlet tubing for aseptic operation. The filter system has a combined surface area of...

John S. Spratt; Robert A. Adcock; Marie Muskovin; William Sherrill; and John McKeown

1980-02-01T23:59:59.000Z

94

Urban Sewage Delivery Heat Transfer System (2): Heat Transfer  

E-Print Network [OSTI]

The thimble delivery heat-transfer (TDHT) system is one of the primary modes to utilize the energy of urban sewage. Using the efficiency-number of transfer units method ( ), the heat-transfer efficiencies of the parallel-flow and reverse-flow TDTH...

Zhang, C.; Wu, R.; Li, X.; Li, G.; Zhuang, Z.; Sun, D.

2006-01-01T23:59:59.000Z

95

Mercury sorbent delivery system for flue gas  

DOE Patents [OSTI]

The invention presents a device for the removal of elemental mercury from flue gas streams utilizing a layer of activated carbon particles contained within the filter fabric of a filter bag for use in a flue gas scrubbing system.

Klunder; ,Edgar B. (Bethel Park, PA)

2009-02-24T23:59:59.000Z

96

E-Print Network 3.0 - automated insulin-delivery systems Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

System In Lungs 11. HIIP- A Novel Inhaled Insulin Delivery System... Biology Navigation HOME >> MEDICINE >> NEWS M New Wireless System Developed to Detect Esophageal Reflux......

97

Temporary blood?brain barrier disruption via focused ultrasound for targeted drug delivery in the brain  

Science Journals Connector (OSTI)

The ability to deliver drugs to the central nervous system is severely limited by the presence of the blood?brain barrier (BBB). This barrier normally serves to protect the brain and restricts the passage of most molecules from being delivered to the brain tissue from the blood stream. We have developed a method by which the BBB is temporarily disrupted in localized regions using low?power ultrasound pulses combined with a circulating ultrasound contrast agent. By systematically focusing at multiple overlapping locations one could prescribe the region in which the BBB is disrupted to conform to a desired target volume reducing drug penetration to the rest of the brain.Ultrasound parameters suited for this procedure are compatible with a device that can focus through the intact skull. In this presentation we will describe recent research on this technique discussing methodology safety possible mechanisms and potential means to guide and monitor the procedure.

Nathan McDannold

2007-01-01T23:59:59.000Z

98

In vitro evaluation of theranostic polymeric micelles for imaging and drug delivery in cancer Rajiv Kumar*, Apurva Kulkarni, Dattatri K Nagesha, Srinivas Sridhar  

E-Print Network [OSTI]

In vitro evaluation of theranostic polymeric micelles for imaging and drug delivery in cancer Rajiv decade engineered nanoplatforms have seen a momentous progress in developing a multimodal theranostic and application of theranostic phospholipid based polymeric micelles for optical fluorescence imaging

Sridhar, Srinivas

99

A Scheme for Reliable Delivery of Events in Distributed Middleware Systems Shrideep Pallickara and Geoffrey Fox  

E-Print Network [OSTI]

A Scheme for Reliable Delivery of Events in Distributed Middleware Systems Shrideep Pallickara. These interactions can be encapsulated in events. We describe a scheme for the reliable delivery of events. In this paper we describe our scheme for the reliable delivery of events within NaradaBrokering [1, 2], which

100

Development of lymphatic drug delivery platforms for the treatment of carcinomas  

E-Print Network [OSTI]

, and evaluated in preclinical rodent models. The route of drug administration along with the controlled release of the drug from the platforms, both play an important role in improving the biopharmaceutical properties of these conjugates. This is demonstrated...

Cai, Shuang

2011-05-31T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Reliability review of the remote tool delivery system locomotor  

SciTech Connect (OSTI)

The locomotor being built by RedZone Robotics is designed to serve as a remote tool delivery (RID) system for waste retrieval, tank cleaning, viewing, and inspection inside the high-level waste tanks 8D-1 and 8D-2 at West Valley Nuclear Services (WVNS). The RTD systm is to be deployed through a tank riser. The locomotor portion of the RTD system is designed to be inserted into the tank and is to be capable of moving around the tank by supporting itself and moving on the tank internal structural columns. The locomotor will serve as a mounting platform for a dexterous manipulator arm. The complete RTD system consists of the locomotor, dexterous manipulator arm, cameras, lights, cables, hoses, cable/hose management system, power supply, and operator control station.

Chesser, J.B.

1999-04-01T23:59:59.000Z

102

Solid lipid nanoparticle and nanoparticle lipid carrier for controlled drug delivery – a review of state of art and recent advances  

Science Journals Connector (OSTI)

It is estimated that nearly 40% of new drug molecules are suffering from poor water solubility, insufficient bioavailability, fluctuating plasma levels or high food dependency. Major efforts have been spent for the development of customised drug carriers to overcome the disappointing in vivo fates of the drug. Both the SLN and NLC are attractive carriers for topical cosmetic and pharmaceutical products. Solid lipid nanoparticles (SLNs) introduced as an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. This paper reviews the present state of the art regarding production techniques for SLN, drug incorporation, loading capacity and drug release, especially focusing on drug release mechanisms. The potential of SLN to be exploited for the different administration routes is highlighted and also reviews about SLN and NLC's stability, toxicity, pharmacokinetic profile, application and its future perspectives.

R. Thiruganesh; S.K. Uma Devi

2010-01-01T23:59:59.000Z

103

E-Print Network 3.0 - anticancer drug delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Chemistry, University of Utah Collection: Chemistry 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

104

Abstract 4469: An evaluation of the role of mucin in nano drug delivery  

Science Journals Connector (OSTI)

...photo-immunotherapy (PIT) can accommodate massive nano-sized reagents deep into tumors. Hisataka...permeability leading to 12- to 25-fold enhanced nano-particle delivery into cancer tissue...EPR). Of particular interest is that nano-sized reagents including macromolecules...

Musaed A. Alkholief and Robert Campbell

2014-10-01T23:59:59.000Z

105

Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Technologies and Technologies and Systems Pipeline Transmission of Hydrogen Strategic Initiatives for Hydrogen Delivery Workshop May 7- 8, 2003 U.S. Department of Energy â–  Hydrogen, Fuel Cells, and Infrastructure Technologies Program Pipeline Transmission of Hydrogen --- 2 Copyright: Design & Operation Standards Relevant Design and Operating Standards ANSI/ASME B31.8 49 CFR 192 CGA H 2 Pipeline Standard (in development) Pipeline Transmission of Hydrogen --- 3 Copyright: Future H 2 Infrastructure Wind Powered Electrolytic Separation Local Reformers Users Stationary Power Sources Vehicle Fueling Stations Distance from Source to User (Miles) <500 0-5 <2,000 <50 Off-peak Hydroelectric Powered Electrolytic Separation Large Reformers (scale economies) Pipeline Transmission of Hydrogen

106

Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...EXPERIMENTAL THERAPEUTICS Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs...India We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs...histopathology, suggesting that the nanoparticle drug delivery system has potential...

Christine M. Johnson; Rajesh Pandey; Sadhna Sharma; G. K. Khuller; Randall J. Basaraba; Ian M. Orme; Anne J. Lenaerts

2005-10-01T23:59:59.000Z

107

Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)  

ScienceCinema (OSTI)

Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

Forte, Trudy

2011-04-28T23:59:59.000Z

108

Fault-Tolerant Reliable Delivery of Messages in Distributed Publish/Subscribe Systems Shrideep Pallickara, Hasan Bulut and Geoffrey Fox  

E-Print Network [OSTI]

1/10 Fault-Tolerant Reliable Delivery of Messages in Distributed Publish/Subscribe Systems Shrideep in distributed systems. In this paper we present our strategy to enable reliable delivery of messages University Abstract Reliable delivery of messages is an important problem that needs to be addressed

109

Chapter III. Processes F. Land-Based N Sources and Their Delivery to Coastal Systems  

E-Print Network [OSTI]

to terrestrial systems of newly fixed N2 (the conversion of relatively inert N2 gas to more bioavailable N forms can be important pathways for delivery of land-based N sources. This chapter focuses on export of N

Seitzinger, Sybil

110

Development and Optimization of Polymeric Carriers for Lymphatic Imaging and Drug Delivery  

E-Print Network [OSTI]

Many cancers, including melanoma and breast cancer, metastasize via the lymphatic system, a mono-directional network of vessels and nodes that parallels the circulatory system. Accurate determination of the lymph nodes ...

Bagby, Taryn Rochelle

2011-12-31T23:59:59.000Z

111

Designing and Assessing a Sustainable Networked Delivery (SND) System: Hybrid Business-to-Consumer Book Delivery Case Study  

Science Journals Connector (OSTI)

Moreover, Americans in particular are enthusiastic about e-commerce options: in 2004, 27% of U.S. Internet users made online purchases, compared with 20% in Japan, 18% in the UK, and 16% in South Korea (6). ... The 30 largest metro areas and other metro areas book purchase patterns by using total household (population) numbers and total book delivery data in the U.S., according to the USPS Household Diary study, were estimated in 2005 as 421 million books delivered to 105,480,101 total U.S. households through the END system (37, 38). ...

Junbeum Kim; Ming Xu; Ramzy Kahhat; Braden Allenby; Eric Williams

2008-12-02T23:59:59.000Z

112

Targeted Nanomedicine for Suppression of CD44 and Simultaneous Cell Death Induction in Ovarian Cancer: An Optimal Delivery of siRNA and Anticancer Drug  

Science Journals Connector (OSTI)

...San Diego, CA Imparting superior control on materials for nanomedicine: The study of degradable, targeted PRINT nanoparticles...development of an effective platform delivery system for use in nanomedicine. Our technique, called PRINT (Particle Replication In...

Vatsal Shah; Oleh Taratula; Olga B. Garbuzenko; Olena R. Taratula; Lorna Rodriguez-Rodriguez; Tamara Minko

2013-11-15T23:59:59.000Z

113

Unibody core–shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging  

Science Journals Connector (OSTI)

Abstract Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core–shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. By conjugating Gd3+ at the stable core and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we developed a theranostic \\{NPs\\} (UCS-Gd-Dox) that achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1 = 0.9 and 14.5 mm?1 s?1 at pH 7.4 and 5.5, respectively). The anti-cancer effect of UCS-Gd-Dox is significantly better than free Dox in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. To the best of our knowledge, this is the simplest approach to obtain the theranostic \\{NPs\\} with Gd-conjugation and Dox doping.

Lin-Chen Ho; Chao-Hsiung Hsu; Chung-Mao Ou; Chia-Wei Wang; Tsang-Pai Liu; Lian-Pin Hwang; Yung-Ya Lin; Huan-Tsung Chang

2015-01-01T23:59:59.000Z

114

Genome-Free Viral Capsids for Targeted Drug Delivery to Breast Cancer  

E-Print Network [OSTI]

Water (ddH 2 O) used in biological procedures or as a reaction solvent was deionized using a NANOpure TM purification system (Water (ddH 2 O) used in biologi- cal procedures or as a reaction solvent was deionized using a NANOpure TM purification system (

Wu, Wesley

2012-01-01T23:59:59.000Z

115

Targeted and stimuli-responsive polymers as chemotherapeutic delivery systems  

E-Print Network [OSTI]

Successful administration of chemotherapeutic agents for cancer treatment requires a balance between the efficacy and the safety of the drug. This often limits physicians to a very narrow therapeutic window. To avoid the ...

Zaman, Noreen Tasneem

2008-01-01T23:59:59.000Z

116

A system for EPID-based real-time treatment delivery verification during dynamic IMRT treatment  

SciTech Connect (OSTI)

Purpose: To design and develop a real-time electronic portal imaging device (EPID)-based delivery verification system for dynamic intensity modulated radiation therapy (IMRT) which enables detection of gross treatment delivery errors before delivery of substantial radiation to the patient.Methods: The system utilizes a comprehensive physics-based model to generate a series of predicted transit EPID image frames as a reference dataset and compares these to measured EPID frames acquired during treatment. The two datasets are using MLC aperture comparison and cumulative signal checking techniques. The system operation in real-time was simulated offline using previously acquired images for 19 IMRT patient deliveries with both frame-by-frame comparison and cumulative frame comparison. Simulated error case studies were used to demonstrate the system sensitivity and performance.Results: The accuracy of the synchronization method was shown to agree within two control points which corresponds to approximately ?1% of the total MU to be delivered for dynamic IMRT. The system achieved mean real-time gamma results for frame-by-frame analysis of 86.6% and 89.0% for 3%, 3 mm and 4%, 4 mm criteria, respectively, and 97.9% and 98.6% for cumulative gamma analysis. The system can detect a 10% MU error using 3%, 3 mm criteria within approximately 10 s. The EPID-based real-time delivery verification system successfully detected simulated gross errors introduced into patient plan deliveries in near real-time (within 0.1 s).Conclusions: A real-time radiation delivery verification system for dynamic IMRT has been demonstrated that is designed to prevent major mistreatments in modern radiation therapy.

Fuangrod, Todsaporn [Faculty of Engineering and Built Environment, School of Electrical Engineering and Computer Science, the University of Newcastle, NSW 2308 (Australia)] [Faculty of Engineering and Built Environment, School of Electrical Engineering and Computer Science, the University of Newcastle, NSW 2308 (Australia); Woodruff, Henry C.; O’Connor, Daryl J. [Faculty of Science and IT, School of Mathematical and Physical Sciences, the University of Newcastle, NSW 2308 (Australia)] [Faculty of Science and IT, School of Mathematical and Physical Sciences, the University of Newcastle, NSW 2308 (Australia); Uytven, Eric van; McCurdy, Boyd M. C. [Division of Medical Physics, CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba R3E 0V9 (Canada) [Division of Medical Physics, CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba R3E 0V9 (Canada); Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba R3T 2N2 (Canada); Department of Radiology, University of Manitoba, Winnipeg, Manitoba R3T 2N2 (Canada); Kuncic, Zdenka [School of Physics, University of Sydney, Sydney, NSW 2006 (Australia)] [School of Physics, University of Sydney, Sydney, NSW 2006 (Australia); Greer, Peter B. [Faculty of Science and IT, School of Mathematical and Physical Sciences, the University of Newcastle, NSW 2308, Australia and Department of Radiation Oncology, Calvary Mater Newcastle Hospital, Locked Bag 7, Hunter region Mail Centre, Newcastle, NSW 2310 (Australia)] [Faculty of Science and IT, School of Mathematical and Physical Sciences, the University of Newcastle, NSW 2308, Australia and Department of Radiation Oncology, Calvary Mater Newcastle Hospital, Locked Bag 7, Hunter region Mail Centre, Newcastle, NSW 2310 (Australia)

2013-09-15T23:59:59.000Z

117

Fault Tolerant Reliable Delivery of Events in Distributed Middleware Systems Shrideep Pallickara, Geoffrey Fox and Hasan Bulut  

E-Print Network [OSTI]

Fault Tolerant Reliable Delivery of Events in Distributed Middleware Systems Shrideep Pallickara our scheme for the reliable delivery of events within NaradaBrokering [1-5], which is a distributed Abstract Reliable delivery of events (or messages, where the terms messages and events are used

118

Control system and method for a power delivery system having a continuously variable ratio transmission  

DOE Patents [OSTI]

A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine.

Frank, Andrew A. (1034 Hillside Ave., Madison, WI 53705)

1984-01-01T23:59:59.000Z

119

The casein micelle as an encapsulation system for triclosan: Methods of micelle dissociation, encapsulation, release, and in vitro delivery.  

E-Print Network [OSTI]

??This dissertation reports on the use of the casein micelle as an encapsulation and potential delivery system for a low molecular weight hydrophobic compound, triclosan.… (more)

Roach, Adrienne L.

2009-01-01T23:59:59.000Z

120

EAC Recommendations on Expanding and Modernizing the Electric Power Delivery System for the 21st Century (September 2014)  

Broader source: Energy.gov [DOE]

EAC Recommendations from the September 2014 meeting on Expanding and Modernizing the Electric Power Delivery System for the 21st Century

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

The electric delivery system-a complex network of transmission and distribu  

Broader source: Energy.gov (indexed) [DOE]

electric delivery system-a complex network of transmission and distribu- electric delivery system-a complex network of transmission and distribu- tion lines, substations, and electrical components-is aging. To deliver more electricity and ensure reliability, the grid needs to be modernized. As the grid is being upgraded, it is also being challenged by increased needs to integrate variable renewable energy resources such as solar and wind, the potential growth of electric vehicles and related charging infrastructure, and the potential development of new electricity market designs and operating practices. To help decision makers better understand how these changes and challenges are shaping electricity delivery systems, as well as provide the industry with the tools necessary to cope with the new designs, the Reliability and Markets activ-

122

New Beam Delivery System Optics: BDS9901 Peter Tenenbaum LCC-Note-0020  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Beam Beam Delivery System Optics: BDS9901 Peter Tenenbaum LCC-Note-0020 14-July-1999 Abstract We describe in detail the optics and XSIF decks for the NLC Beam Delivery System in its present version, BDS9901. 1 Introduction In this Note, we describe the present optics design of the NLC Beam Delivery System, which has been somewhat revised for 1999. Most important optical changes include: * Organization of BPMs into quad-style (BPMQ), BPMs in feedback loops (BPMFB), BPMs which provide sub-train/multibunch information (BPMMB), and BPMs used to measure beam-beam deflections (BPMIP) * Addition of a number of small quad, skew-quad, sextupole, and skew-sextupole tuning mag- nets * Addition of actuators for the feedbacks * A 6-quadrupole final telescope, which allows all of the linear degrees of freedom to be opti- mized * Replacement of the low-energy final quads Q1A and Q1B with a single

123

Microspheres for Drug Delivery  

Science Journals Connector (OSTI)

With advances in biotechnology, genomics, and combinatorial chemistry, a wide variety of new, more potent and specific therapeutics are being created. Because of common problems such as low solubility, high po...

Kyekyoon Kevin Kim; Daniel W. Pack

2006-01-01T23:59:59.000Z

124

A Novel Power Delivery Method for Asynchronous Loads in Energy Harvesting Systems  

Science Journals Connector (OSTI)

For systems depending on power harvesting, a fundamental contradiction in the power delivery chain has existed between conventional synchronous computational loads requiring relatively stable Vdd and power harvesters unable to supply it. DC/DC conversion ... Keywords: Switched capacitor DC/DC converter, asynchronous circuits, capacitor bank, energy harvesting, intelligent task and power scheduling, piezoelectric element

Xuefu Zhang; Delong Shang; Fei Xia; Alex Yakovlev

2011-12-01T23:59:59.000Z

125

Electrical-Thermal Co-analysis for Power Delivery Networks in 3D System Integration  

E-Print Network [OSTI]

Electrical-Thermal Co-analysis for Power Delivery Networks in 3D System Integration Jianyong Xie1 Rubin3 1 School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332 2 IBM Package Design, Development, and Electrical Services Group, Poughkeepsie, N.Y. 12601 3 IBM T

Swaminathan, Madhavan

126

Drugs affecting autonomic functions or the extrapyramidal system  

Science Journals Connector (OSTI)

Publisher Summary This chapter discusses the drugs that stimulate ?- and ?-adrenoceptors. These drugs include Adrenaline (epinephrine), ephedrine, and pseudoephrine. The effects of ephedrine and pseudoephedrine on the cardiovascular system are presented. Ephedrine and pseudoephedrine also have the potential for neuropsychiatric adverse events. The chapter discusses the adverse effects of levodopa, a drug that acts on dopamine receptors, on the nervous- and psychiatric-system. The adverse effects of dopamine receptor agonists are discussed on cardiovascular-, respiratory-, and nervous system. Most of the dopamine receptor agonists in current use are ergot derivatives, and these are known to cause serosal fibroinflammatory syndromes. The ergot alkaloids and related agents are discussed in the chapter. Despite the advent of the triptans, ergotamine is still used in the treatment of migraine, sometimes with predictable adverse effects.

Michael Schachter

2001-01-01T23:59:59.000Z

127

A Cassette Based System for Hydrogen Storage and Delivery  

SciTech Connect (OSTI)

A hydrogen storage system is described and evaluated. This is based upon a cassette, that is a container for managing hydrogen storage materials. The container is designed to be safe, modular, adaptable to different chemistries, inexpensive, and transportable. A second module receives the cassette and provides the necessary infrastructure to deliver hydrogen from the cassette according to enduser requirements. The modular concept has a number of advantages over approaches that are all in one stand alone systems. The advantages of a cassette based system are discussed, along with results from model and laboratory testing.

Britton Wayne E.

2006-11-29T23:59:59.000Z

128

Hedva_roffe@edwards.com# to be send to4120CVs remarking position R&D Delivery systems Engineer Position #1204  

E-Print Network [OSTI]

Position #1204 R&D Delivery systems EngineerPosition' title: Develop and design Delivery systems systems design in the medical devices industry Proven Solid-works experience Lab testing mustHedva_roffe@edwards.com# to be send to4120CVs remarking position R&D Delivery systems Engineer

Rimon, Elon

129

System and method for delivery of neutron beams for medical therapy  

DOE Patents [OSTI]

A neutron delivery system that provides improved capability for tumor control during medical therapy is disclosed. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention. 5 figs.

Nigg, D.W.; Wemple, C.A.

1999-07-06T23:59:59.000Z

130

System and method for delivery of neutron beams for medical therapy  

DOE Patents [OSTI]

A neutron delivery system that provides improved capability for tumor control during medical therapy. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention.

Nigg, David W. (Idaho Falls, ID); Wemple, Charles A. (Idaho Falls, ID)

1999-01-01T23:59:59.000Z

131

Methodology for the production and delivery of generative music for the personal listener : systems for realtime generative music production   

E-Print Network [OSTI]

This thesis will describe a system for the production of generative music through specific methodology, and provide an approach for the delivery of this material. The system and body of work will be targeted specifically ...

Murphy, Michael J.

2013-11-27T23:59:59.000Z

132

"Working to upgrade electrical generation and delivery systems."  

E-Print Network [OSTI]

for organic solar cells. Our studies focus on determination of the physical mechanisms that limit, we have established a solar cell program. We work with chemists, who synthesize new materials-bandwidth products to accommodate the ever-increasing bit rates of fiber-optics systems. Recently, imaging

Acton, Scott

133

Alternate Air Delivery Systems for Hot and Humid Climates  

E-Print Network [OSTI]

-zone units in the Harris County Criminal Courts Building in Houston, one of the most hot and humid climates in the United States, as well as in several other facilities. This paper will discuss the adoption of ASHRAE 62, its effects on VAV systems, and how...

Wallace, M.

1996-01-01T23:59:59.000Z

134

Characterization of a sustained-release delivery system for combined cytokine/peptide vaccination using a poly-N-acetyl glucosamine-based polymer matrix.  

Science Journals Connector (OSTI)

...Sustained-Release Delivery System kines svhich are...28. 29). The vehicle. therefore...MARTI (14). Detection of MART-i Peptide...p-GlcNAc de-livery system vehicle for a cytokine...p-G1cNAc delivery system vehicle for a cytokine...

D J Cole; S Gattoni-Celli; E F McClay; J S Metcalf; J M Brown; N Nabavi; D A Newton, 3rd; C B Woolhiser; M C Wilson; and J N Vournakis

1997-06-01T23:59:59.000Z

135

Nanoparticle Agglomeration via Ionic Colloidal Destabilization as a Novel Approach to Dry Powder Formulations for Pulmonary Drug Delivery  

E-Print Network [OSTI]

Efficient administration of poorly water soluble drugs represents a leading challenge in pulmonary medicine. This route of administration has been used for steroidal treatments for some time, but with room for advancement. New inhalable medicines...

Plumley, Carl Joseph

2008-08-05T23:59:59.000Z

136

Cost and Area Comparison Per Student of the Public Elementary Schools in Texas based on the Project Delivery Systems  

E-Print Network [OSTI]

It has been shown that there exists a correlation between the cost of construction of elementary schools and the project delivery systems. Previous research showed that Competitive Sealed proposal contract method of construction is $4000 cheaper...

Goyal Rakesh, Sheetal

2013-08-09T23:59:59.000Z

137

Internet-Based Delivery and Deployment of Document Management Systems Borko Furht, Florida Atlantic University, Boca Raton, Florida  

E-Print Network [OSTI]

) approach implemented by CyLex Systems in deploying document management systems. 1. Introduction Electronic management systems. 2. Present Approaches to Document Management Systems The traditional approach in documentInternet-Based Delivery and Deployment of Document Management Systems Borko Furht, Florida Atlantic

Furht, Borko

138

Analysis of 2009 ENR Best Projects in Texas to Determine the Impact of Project Delivery System Used  

E-Print Network [OSTI]

ANALYSIS OF 2009 ENR BEST PROJECTS IN TEXAS TO DETERMINE THE IMPACT OF PROJECT DELIVERY SYSTEM USED A Thesis by NAVANEETHAN RAJAN Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE December 2010 Major Subject: Construction Management Analysis of 2009 ENR Best Projects in Texas to Determine the Impact of Project Delivery System Used...

Rajan, Navaneethan

2011-02-22T23:59:59.000Z

139

Source and Extraction for Simultaneous Four-hall Beam Delivery System at CEBAF  

SciTech Connect (OSTI)

A new design for simultaneous delivery of the electron beam to all four 12 GeV CEBAF experimental halls* requires a new 750 MHz RF separator system in the 5th pass extraction region, a 250 MHz repetition rate for its beams, and addition of a fourth laser at the photo-cathode gun. The proposed system works in tandem with the existing 500 MHz RF separators and beam repetition rate on the lower passes. The new 5th pass RF separators will have the same basic design but modified to run at 750 MHz. The change to the beam repetition rate will be at the photo-cathode gun through an innovative upgrade of the seed laser driver system using electro-optic modulators. The new laser system also allows addition of the fourth laser. The new RF separators, the new laser system and other hardware changes required to implement the Four-Hall operation delivery system will be discussed in this paper.

Kazimi, Reza; Wang, Haipeng; Spata, Mike F.; Hansknecht, John C.

2013-06-01T23:59:59.000Z

140

Hydrogen Delivery Analysis Models  

Broader source: Energy.gov [DOE]

DOE H2A Delivery Models: Components Model (delivery system component costs and performance) and Scenario Model (for urban and rural/interstate markets and demand levels, market penetration)

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Soil chemical sensor and precision agricultural chemical delivery system and method  

DOE Patents [OSTI]

A real time soil chemical sensor and precision agricultural chemical delivery system includes a plurality of ground-engaging tools in association with individual soil sensors which measure soil chemical levels. The system includes the addition of a solvent which rapidly saturates the soil/tool interface to form a conductive solution of chemicals leached from the soil. A multivalent electrode, positioned within a multivalent frame of the ground-engaging tool, applies a voltage or impresses a current between the electrode and the tool frame. A real-time soil chemical sensor and controller senses the electrochemical reaction resulting from the application of the voltage or current to the leachate, measures it by resistivity methods, and compares it against pre-set resistivity levels for substances leached by the solvent. Still greater precision is obtained by calibrating for the secondary current impressed through solvent-less soil. The appropriate concentration is then found and the servo-controlled delivery system applies the appropriate amount of fertilizer or agricultural chemicals substantially in the location from which the soil measurement was taken. 5 figures.

Colburn, J.W. Jr.

1991-07-23T23:59:59.000Z

142

Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

new solid and liquid phase systems new solid and liquid phase systems for the containment, transport and delivery of hydrogen By Guido P. Pez Hydrogen Energy Infrastructure for Fuel Cell Vehicle Transportation Scenario A: Distributed H 2 from a Large Scale Plant (150-230 tonne/day) Large Scale H 2 Plant (300-800 psi H 2 ) H 2 Buffer Storage Tube Trailer Liquid H 2 Truck H 2 Pipeline Multi-vehicle filling stations Feedstock: N. gas, Coal, Biomass Pet. Coke, Resids. Future: Carbon sequestration Storage: Underground well? Output: Depends on the vehicle's H 2 storage technology Currently H 2 up to >6000 psi for 5000 psi tanks Scenario B: Hydrogen by a small scale reforming of pipeline natural gas and compression Natural Gas Pipeline Reformer Liquid H 2 Backup Compressor H 2 (>6000 psig) H 2 Production: 100-400 kg/day; 4-5Kg H

143

Energy Sector Stakeholders Attend the Department of Energy¬タルs 2010 Cybersecurity for Energy Delivery Systems Peer Review  

Broader source: Energy.gov (indexed) [DOE]

Sector Stakeholders Attend the Department of Energy's Cybersecurity for Energy Delivery Sector Stakeholders Attend the Department of Energy's Cybersecurity for Energy Delivery Systems Peer Review July 29, 2010 The Department of Energy conducted a Peer Review of its Cybersecurity for Energy Delivery Systems (CEDS) Research and Development Program on July 20-22, during which 28 R&D projects were presented for review by industry stakeholders. More than 65 energy sector stakeholders came to network, present, and learn about DOE projects, while more than 20 joined in by webinar. The CEDS program's national lab, academic, and industry partners-including the National SCADA Test Bed (NSTB) partners and Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) project- presented DOE-supported efforts involving secured SCADA communications and smart grid applications,

144

Microsoft Word - LCC-0135 Machine Protection Issues in the Beam Delivery System.doc  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

5 5 SLAC-TN-04-039 November 2003 Abstract This note documents a set of expressions used to explore the issue of whether or not it is reasonable to consider a conventional positron source for a Tesla formatted beam. The critical issue is that of energy deposition in the conversion target and the comparison of the induced stress with the ultimate tensile strength of the target material. Since the length of the incident beam pulse is large in comparison to the ratio of beam size to the speed of sound, the concurrent pressure pulse dissipates in a time short compared to the overall pulse duration and one is left with only the Machine Protection Issues in the Beam Delivery System L. Keller and T. Markiewicz Stanford Linear Accelerator Center

145

A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release  

E-Print Network [OSTI]

localization of therapeutic compounds than is possible with existing technology. Despite recent advance- ments release Aram J. Chung & Yun Suk Huh & David Erickson Published online: 8 April 2009 # Springer Science the survival rate in porcine cases and more recently Krismer et al. (2005) reported for human as well

Erickson, David

146

A Bi-Mix Antibacterial Drug-Delivery System for Regenerative Endodontics. Jadesada Palasuk1  

E-Print Network [OSTI]

), Kruskal-Wallis and Mann-Whitney tests were performed (=0.05). The results showed that uniaxial tensile

Zhou, Yaoqi

147

Utah-Inha Joint Research Center on Drug Delivery Systems & Advanced Therapeutics  

E-Print Network [OSTI]

Theranostics for cancer #12;7 Why Korea? Korea has a well-trained technical workforce with modern biomedical

Tipple, Brett

148

Waste Feed Delivery System Phase 1 Preliminary Reliability and Availability and Maintainability Analysis [SEC 1 and 2  

SciTech Connect (OSTI)

The document presents updated results of the preliminary reliability, availability, maintainability analysis performed for delivery of waste feed from tanks 241-AZ-101 and 241-AN-105 to British Nuclear Fuels Limited, inc. under the Tank Waste Remediation System Privatization Contract. The operational schedule delay risk is estimated and contributing factors are discussed.

CARLSON, A.B.

1999-11-11T23:59:59.000Z

149

NGNP Data Management and Analysis System Analysis and Web Delivery Capabilities  

SciTech Connect (OSTI)

Projects for the Very High Temperature Reactor (VHTR) Technology Development Office provide data in support of Nuclear Regulatory Commission licensing of the very high temperature reactor. Fuel and materials to be used in the reactor are tested and characterized to quantify performance in high-temperature and high-fluence environments. The NGNP Data Management and Analysis System (NDMAS) at the Idaho National Laboratory has been established to ensure that VHTR data are (1) qualified for use, (2) stored in a readily accessible electronic form, and (3) analyzed to extract useful results. This document focuses on the third NDMAS objective. It describes capabilities for displaying the data in meaningful ways and for data analysis to identify useful relationships among the measured quantities. The capabilities are described from the perspective of NDMAS users, starting with those who just view experimental data and analytical results on the INL NDMAS web portal. Web display and delivery capabilities are described in detail. Also the current web pages that show Advanced Gas Reactor, Advanced Graphite Capsule, and High Temperature Materials test results are itemized. Capabilities available to NDMAS developers are more extensive, and are described using a second series of examples. Much of the data analysis efforts focus on understanding how thermocouple measurements relate to simulated temperatures and other experimental parameters. Statistical control charts and correlation monitoring provide an ongoing assessment of instrument accuracy. Data analysis capabilities are virtually unlimited for those who use the NDMAS web data download capabilities and the analysis software of their choice. Overall, the NDMAS provides convenient data analysis and web delivery capabilities for studying a very large and rapidly increasing database of well-documented, pedigreed data.

Cynthia D. Gentillon

2011-09-01T23:59:59.000Z

150

Design and optimization of a multi-particle accelerator beam transport and delivery system for material irradiation in nuclear and fusion science  

E-Print Network [OSTI]

A beam delivery and transport system were designed for the use in MIT Materials Test Facility (M2TF). The purpose of this beam delivery system was to design a 36 MeV Proton Cyclotron for DPA accumulation and a 100 MeV ...

Sordelet, Tyler Christopher

2012-01-01T23:59:59.000Z

151

Oral Drug Absorption  

E-Print Network [OSTI]

properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

Yamashita, Shinji

2006-10-26T23:59:59.000Z

152

The University of the West Indies satellite delivery system for continuing engineering education  

Science Journals Connector (OSTI)

The University of the West Indies (UWI) serves 14 territories separated by ocean and spread over a geographical area of about 1500 km in radius. The region would be well served by distance education. In 1983 the University of the West Indies Distance Teaching Experiment (UWIDITE) was launched using satellite communications to link the territories. UWIDITE is mainly an interactive audio system with slow-scan TV, telewriting and computer link-up. In 1986 the Faculty of Engineering embarked on a program of full-motion video continuing engineering education and has since been a regular participant in live interactive video conferences, symposia and other activities via satellite. Previous papers have outlined experiences with satellite delivery of continuing engineering education in the West Indies and it was concluded that the Faculty of Engineering has a pivotal role to play in the development of greater use of satellites in CEE in the region and to serve as a pilot project for full motion video instruction for the University of the West Indies. The full-motion video satellite facilities at present allow for reception only of satellite signals in the C-band range of frequencies. This paper details a system which would allow for transmission as well as reception of both C- and Ku-band signals within the University of the West Indies, and other institutions regionally and internationally.

Clement A.C. lmbert; Ashton J. Parris

1992-01-01T23:59:59.000Z

153

Hydrogen Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mark Paster Energy Efficiency and Renewable Energy Hydrogen, Fuel Cells and Infrastructure Technology Program Hydrogen Production and Delivery Team Hydrogen Delivery Goal Hydrogen Delivery Goal Liquid H 2 & Chem. Carriers Gaseous Pipeline Truck Hydrides Liquid H 2 - Truck - Rail Other Carriers Onsite reforming Develop Develop hydrogen fuel hydrogen fuel delivery delivery technologies that technologies that enable the introduction and enable the introduction and long long - - term viability of term viability of hydrogen as an energy hydrogen as an energy carrier for transportation carrier for transportation and stationary power. and stationary power. Delivery Options * End Game - Pipelines - Other as needed * Breakthrough Hydrogen Carriers * Truck: HP Gas & Liquid Hydrogen

154

Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer  

Science Journals Connector (OSTI)

...Molecular Targets, and Chemical Biology Nanoparticle Targeting of Anticancer Drug Improves...14263. Prior studies suggested that nanoparticle drug delivery might improve the therapeutic...responses not possible with a free drug. Nanoparticle|drug delivery|PAMAM dendrimer...

Jolanta F. Kukowska-Latallo; Kimberly A. Candido; Zhengyi Cao; Shraddha S. Nigavekar; Istvan J. Majoros; Thommey P. Thomas; Lajos P. Balogh; Mohamed K. Khan; James R. Baker, Jr.

2005-06-15T23:59:59.000Z

155

Dosimetric verification of IMAT delivery with a conventional EPID system and a commercial portal dose image prediction tool  

SciTech Connect (OSTI)

Purpose: The electronic portal imaging device (EPID) is a system for checking the patient setup; as a result of its integration with the linear accelerator and software customized for dosimetry, it is increasingly used for verification of the delivery of fixed-field intensity-modulated radiation therapy (IMRT). In order to extend such an approach to intensity-modulated arc therapy (IMAT), the combined use of an EPID system and a portal dose image prediction (PDIP) tool has been investigated. Methods: The dosimetric behavior of an EPID system, mechanically reinforced to maintain its positional stability during the accelerator gantry rotation, has been studied to assess its ability to measure portal dose distributions for IMAT treatment beams. In addition, the PDIP tool of a commercial treatment planning system, commonly used for static IMRT dosimetry, has been validated for simulating the PDIs of IMAT treatment fields. The method has been applied to the delivery verification of 23 treatment fields that were measured in their dual mode of IMRT and IMAT modalities. Results: The EPID system has proved to be appropriate for measuring the PDIs of IMAT fields; additionally the PDIP tool was able to simulate these accurately. The results are quite similar to those obtained for static IMRT treatment verification, although it was necessary to investigate the dependence of the EPID signal and of the accelerator monitor chamber response on variable dose rate. Conclusions: Our initial tests indicate that the EPID system, together with the PDIP tool, is a suitable device for the verification of IMAT plan delivery; however, additional tests are necessary to confirm these results.

Iori, Mauro; Cagni, Elisabetta; Paiusco, Marta; Munro, Peter; Nahum, Alan E. [Servizio di Fisica Sanitaria, Arceispedale S. Maria Nuova, Reggio Emilia 42100 (Italy); Varian Medical Systems, Palo Alto, California 94304 (United States); Department of Physics, Clatterbridge Centre for Oncology, Bebington CH63 4JY (United Kingdom)

2010-01-15T23:59:59.000Z

156

Instrument Failures for the da Vinci Surgical System: a Food and Drug Administration MAUDE Database Study  

E-Print Network [OSTI]

reports. The majority of failures (285) were of the instrument's wrist or tool tip. Cautery problemsInstrument Failures for the da Vinci Surgical System: a Food and Drug Administration MAUDE Database Background Our goal was to analyze reported instances of the da Vinci robotic surgical system instrument

157

Floating hot-melt extruded tablets for gastroretentive controlled drug release system  

E-Print Network [OSTI]

a gastric floating dosage form using the puff ability at the die of a twin-screw extruder. Wei et al. [21Floating hot-melt extruded tablets for gastroretentive controlled drug release system Mamoru Fukuda bicarbonate on the physicochemical properties of controlled release hot- melt extruded (HME) tablets

Peppas, Nicholas A.

158

Design of a robust, intuitive piston interface for a needle free injection system  

E-Print Network [OSTI]

The MIT BioInstrumentation Lab's linear Lorentz force actuator based needle free injection system has been shown to have numerous benefits over needle-based and other needle-free drug delivery systems in a research ...

Nawrot, Michael Thomas

2014-01-01T23:59:59.000Z

159

Abstract CN01-02: canSAR: An integrated cancer drug discovery informatics platform allowing systematic target evaluation.  

Science Journals Connector (OSTI)

...drugs, due to their chemical composition, are unsuitable...nanogel drug delivery platform that can (i) encapsulate...nanogels: a versatile platform for drug delivery to...drugs, due to their chemical composition, are unsuitable...nanogel drug delivery platform that can (i) encapsulate...

Bissan Al-Lazikani; Mishal Patel; Krishna Bulusu; and Mark Halling-Brown

2011-11-01T23:59:59.000Z

160

FCT Hydrogen Delivery: Current Technology  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Current Technology to someone Current Technology to someone by E-mail Share FCT Hydrogen Delivery: Current Technology on Facebook Tweet about FCT Hydrogen Delivery: Current Technology on Twitter Bookmark FCT Hydrogen Delivery: Current Technology on Google Bookmark FCT Hydrogen Delivery: Current Technology on Delicious Rank FCT Hydrogen Delivery: Current Technology on Digg Find More places to share FCT Hydrogen Delivery: Current Technology on AddThis.com... Home Basics Current Technology R&D Activities Quick Links Hydrogen Production Hydrogen Storage Fuel Cells Technology Validation Manufacturing Codes & Standards Education Systems Analysis Contacts Current Technology Today, hydrogen is transported from the point of production to the point of use via pipeline, over the road in cryogenic liquid trucks or gaseous tube

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Safe and compact ammonia storage/delivery systems for SCR-DeNOX...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Safe and compact ammonia storagedelivery systems for SCR-DeNOX in automotive units Safe and compact ammonia storagedelivery systems for SCR-DeNOX in automotive units Presentation...

162

Anti-HER2 Cationic Immunoemulsion as a Potential Targeted Drug Delivery System for the Treatment of Prostate Cancer  

Science Journals Connector (OSTI)

...and response to treatment with a HER2-directed...single agent for the treatment of these patients...concentrations in oil/water nanoemulsions will...Germany) at 25C using water as the solvent...unconjugated mAbs by dialysis using a polyvinylidene...for transmission electron microscopy (TEM...

Danny Goldstein; Ofer Gofrit; Abraham Nyska; and Simon Benita

2007-01-01T23:59:59.000Z

163

A Carbohydrate Recognition–Based Drug Delivery and Controlled Release System using Intraperitoneal Macrophages as a Cellular Vehicle  

Science Journals Connector (OSTI)

...rates and earlier tumor development compared with p53PTP1B...PTP1B regulates B-cell development. To our knowledge...University Research and Ethic Animal Committee, and...et al. Increased energy expenditure, decreased...during colorectal-tumor development. N Engl J Med 1988...

Yuzuru Ikehara; Toru Niwa; Le Biao; Sanae Kabata Ikehara; Norifumi Ohashi; Takeshi Kobayashi; Yoshitaka Shimizu; Naoya Kojima; and Hayao Nakanishi

2006-09-01T23:59:59.000Z

164

Anti-tumor effect and immuno-toxicity of target-specific drug delivery system: Doxorubicin-encapsulated nano particle  

Science Journals Connector (OSTI)

...Abstract #788: Long-term exposure to Nano-TiO2 promotes genomic instability and...Denver, CO Titanium dioxide (TiO2) nano-particles (100 nm in diameter) have...However, recent studies have shown that TiO2 nano-particles (nano-TiO2) induce cytotoxicity...

Hyunah Lee; Eui Jin Kim; Jeong-Jun Yu; Soo-Won Shu; Young Hyeh Ko; Jinny Park; Keun Chil Park; Hong Ghi Lee

2004-04-01T23:59:59.000Z

165

A Carbohydrate Recognition–Based Drug Delivery and Controlled Release System using Intraperitoneal Macrophages as a Cellular Vehicle  

Science Journals Connector (OSTI)

...gliomas. Cancer Res 2005;65:3307-18. 31 Dullens HF, Rademakers LH, Doffemont M, Van Veen PT, Bulder R, Den Otter W...Invasion Metastasis 1993;13:267-76. 32 Dullens HF, Rademakers LH, Cluistra S, et al. Parathymic lymph nodes during growth...

Yuzuru Ikehara; Toru Niwa; Le Biao; Sanae Kabata Ikehara; Norifumi Ohashi; Takeshi Kobayashi; Yoshitaka Shimizu; Naoya Kojima; Hayao Nakanishi

2006-09-01T23:59:59.000Z

166

A simple system for remote processing and delivery of H{sub 2}[{sup 15}O] produced from a N{sub 2}/H{sub 2} target  

SciTech Connect (OSTI)

The N{sub 2} + H{sub 2} target can produce more than enough H{sub 2}[{sup 15}O] to meet the demands of any PET imaging facility. We have shown that the radiotracer can be transported across 300 feet of tubing without significant loss of activity, using fast tows of target gas. Thus, there is no need to maintain an extraneous chemical Processing station at the PET imaging facility. A simple remotely operated system is reported that performs the three step operation for H{sub 2}[{sup 15}O] delivery at the PET imaging facility: collection of the radiotracer in water; removal of ammonia from the preparation and delivery of the radiotracer to the injection syringe. The system can process and make available for injection 100 mCi of H{sub 2}[{sup 15}O]. The machine is easily prepped for subsequent deliveries. So that additional doses of radiotracer can be made available within 12 minutes. A general syringe loading device with remote hydraulic injector is that is compatible for use with any H{sub 2}[{sup 15}O] radiotracer processing station. The device allows for direct measurement of syringe dose while filling, and for easy, as well as safe transfer of the injection syringe assembly to a delivery cart that houses the remote hydraulic injector. The injection syringe is never handled directly during transport nor during injection except, to connect it to the intravenous line, thus minimizing radiation exposure to personnel.

Ferrieri, R.A.; Alexoff, D.L.; Schlyer, D.L.; Wolf, A.P.

1993-12-31T23:59:59.000Z

167

One System Integrated Project Team: Retrieval And Delivery Of The Hanford Tank Wastes For Vitrification In The Waste Treatment Plant  

SciTech Connect (OSTI)

The One System Integrated Project Team (IPT) was formed in late 2011 as a way for improving the efficiency of delivery and treatment of highly radioactive waste stored in underground tanks at the U.S. Department of Energy's (DOE's) 586-square-mile Hanford Site in southeastern Washington State. The purpose of the One System IPT is to improve coordination and integration between the Hanford's Waste Treatment Plant (WTP) contractor and the Tank Operations Contractor (TOC). The vision statement is: One System is a WTP and TOC safety conscious team that, through integrated management and implementation of risk-informed decision and mission-based solutions, will enable the earliest start of safe and efficient treatment of Hanford's tank waste, to protect the Columbia River, environment and public. The IPT is a formal collaboration between Bechtel National, Inc. (BNI), which manages design and construction of the WTP for the U.S. Department of Energy's Office of River Protection (DOEORP), and Washington River Protection Solutions (WRPS), which manages the TOC for ORP. More than fifty-six (56) million gallons of highly radioactive liquid waste are stored in one hundred seventy-seven (177) aging, underground tanks. Most of Hanford's waste tanks - one hundred forty-nine (149) of them - are of an old single-shell tank (SST) design built between 1944 and 1964. More than sixty (60) of these tanks have leaked in the past, releasing an estimated one million gallons of waste into the soil and threatening the nearby Columbia River. There are another twenty-eight (28) new double-shelled tanks (DSTs), built from 1968 to 1986, that provide greater protection to the environment. In 1989, DOE, the U.S. Environmental Protection Agency (EPA), and the Washington State Department of Ecology (Ecology) signed a landmark agreement that required Hanford to comply with federal and state environmental standards. It also paved the way for agreements that set deadlines for retrieving the tank wastes and for building and operating the WTP. The tank wastes are the result of Hanford's nearly fifty (50) years of plutonium production. In the intervening years, waste characteristics have been increasingly better understood. However, waste characteristics that are uncertain and will remain as such represent a significant technical challenge in terms of retrieval, transport, and treatment, as well as for design and construction ofWTP. What also is clear is that the longer the waste remains in the tanks, the greater the risk to the environment and the people of the Pacific Northwest. The goal of both projects - tank operations and waste treatment - is to diminish the risks posed by the waste in the tanks at the earliest possible date. About two hundred (200) WTP and TOC employees comprise the IPT. Individual work groups within One System include Technical, Project Integration & Controls, Front-End Design & Project Definition, Commissioning, Nuclear Safety & Engineering Systems Integration, and Environmental Safety and Health and Quality Assurance (ESH&QA). Additional functions and team members will be added as the WTP approaches the operational phase. The team has undertaken several initiatives since its formation to collaborate on issues: (1) alternate scenarios for delivery of wastes from the tank farms to WTP; (2) improvements in managing Interface Control Documents; (3) coordination on various technical issues, including the Defense Nuclear Facilities Nuclear Safety Board's Recommendation 2010-2; (4) deployment of the SmartPlant? Foundation-configuration Management System; and (5) preparation of the joint contract deliverable of the Operational Readiness Support Plan.

Harp, Benton J. [Department of Energy, Office of River Protection, Richland, Washington (United States); Kacich, Richard M. [Bechtel National, Inc., Richland, WA (United States); Skwarek, Raymond J. [Washington River Protection Solutions LLC, Richland, WA (United States)

2012-12-20T23:59:59.000Z

168

Asymptotically Optimal Algorithms for One-to-One Pickup and Delivery Problems With Applications to Transportation Systems  

E-Print Network [OSTI]

Pickup and delivery problems (PDPs), in which objects or people have to be transported between specific locations, are among the most common combinatorial problems in real-world logistical operations. A widely-encountered ...

Pavone, Marco

169

Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport  

E-Print Network [OSTI]

Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

Tang, Hua, 1972-

2002-01-01T23:59:59.000Z

170

E-Print Network 3.0 - anticancer drug pump Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Therapeutic Delivery (2010) 1(2), 323334 Special FocuS: oncology Summary: drug efflux pumps, increasing drug metabolism, enhancing self-repairing ability or expressing altered......

171

Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Gaseous Hydrogen Gaseous Hydrogen Delivery Breakout Strategic Directions for Hydrogen Delivery Workshop May 7-8, 2003 Crystal City, Virginia Breakout Session Name Targets/Objectives More work is needed to better define delivery target metrics Assumptions about targets for costs and energy efficiency need to be qualified Technology improvements likely to lower costs, but may not have major impact on total cost A significant impact on cost would come through permitting policy changes, e.g., use of public land Breakout Session Name Priority Barriers System Issues: need to assess delivery options in context of total system Materials: corrosion, H2 permeability Construction: welding, joining Maintenance and Operation: leak detection Pipeline Safety: odorants, flame visibility

172

E-Print Network 3.0 - advocates expanded delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

POLICY AND MANAGEMENT JULY 14, 2010 Summary: DELIVERY SYSTEM REDESIGN The US health care delivery system is expensive, fragmented, highly decentralized... , efficient, and...

173

The Impact of the Katy Management of Automated Curriculum System on Planning for Learning, Delivery of Instruction and Evaluation of Student Learning as Perceived by Teachers in the Katy Independent School District in Texas  

E-Print Network [OSTI]

The purpose of this study was to determine teachers’ perceptions of the relationship of the Katy Management of Automated Curriculum (KMAC) system developed by Katy ISD in Katy, Texas, on planning for learning, delivery of instruction and evaluation...

Hogue, Sharon L.

2011-10-21T23:59:59.000Z

174

Cybersecurity Procurement Language for Energy Delivery (April 2014)  

Broader source: Energy.gov [DOE]

To assist with embedding cybersecurity in the procurement of energy delivery systems, this Cybersecurity Procurement Language for Energy Delivery Systems guidance document provides baseline cybersecurity procurement language for use by asset owners, operators, integrators, and suppliers during the procurement process.

175

Delivery Tech Team  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Tech Team Tech Team Oak Ridge National Laboratory January, 2005 Team Members * Tony Bouza: DOE * Nick Burkhead: SC * Dan Casey: CVX * Maria Curry- Nkansah: BP* * Jim Kegerreis: XOM * George Parks: COP** * Mark Paster: DOE** * Steve Pawel: ORNL * Jim Simnick: BP * FOG Liaison ** Co-Leads Shawna McQueen (Energetics): Facilitator Mission * Provide a forum for the Partnership to help advance research aimed at developing low cost, safe, and energy efficient hydrogen delivery systems * Catalyze the development of hydrogen delivery technologies that enable the introduction and long-term viability of hydrogen as an energy carrier for transportation and stationary power Useful Facts * 1 kg H 2 = 1 gallon gasoline * Eff FCV = 2-3 x Eff ICEV = 1.2-1.4 x Eff HEV * Energy Density - 10,000 psi H 2 = 1.3 kWhr/l

176

Nanomedicine and drug delivery: a mini review  

Science Journals Connector (OSTI)

The field of nanotechnology now has pivotal roles in electronics, biology and medicine. Its application can be appraised, as it involves the materials to be designed at atomic and molecular level. Due to the a...

Agha Zeeshan Mirza; Farhan Ahmed Siddiqui

2014-02-01T23:59:59.000Z

177

NCI Image-Guided Drug Delivery Summit  

Science Journals Connector (OSTI)

...effects on human health and quality of life. Implications for...statisticians, mathematicians, engineers, and computer scientists...mathematicians, statisticians, and engineers in addition to computer scientists...Sequence verification as quality control step for production...

Pushpa Tandon and Keyvan Farahani

2011-01-15T23:59:59.000Z

178

Physicochemical investigations of a drug delivery oscillator  

E-Print Network [OSTI]

75 mM Glucose/10 % MAA /kmarble= 0.00199 s-1 I = 50 mM (50 mM NaCl+0 mM CaCl2) I = 95 mM (50 mM NaCl + 15 mM CaCl2) I = 155 mM (50 mM NaCl+ 35 mM CaCl2) I = 155 mM (155 mM NaCl+ 0 mM CaCl2) p H Device Membrane - Hydrogel N...4.6 4.7 4.8 4.9 5 5.1 5.2 5.3 5.4 0 0.2 0.4 0.6 0.8 1 Time (Days) p H Glucose Gluconic acid Gluconic acid Gluconate- + H+ H+ + CaCO3 Ca 2+ + HCO3- H+ + HCO3- H2CO3 pKa = 6.37 H2CO3 CO2 ? + H2O pKa = 3.6 ? Buffer Build-Up Affects...

Bhalla, A. S.; Siegel, R. A.

2006-10-27T23:59:59.000Z

179

NANOTECHNOLOGY IN DIAGNOSTICS AND DRUG DELIVERY  

Science Journals Connector (OSTI)

The current state nanotechnology is comparable with the level of technological ... for a large portion of manufactured goods. Nanotechnology industry is currently in an equivalent infant ... , will reach $1 trill...

Hwa A. Lim

2004-07-01T23:59:59.000Z

180

Drug delivery device for bladder disorders  

E-Print Network [OSTI]

Several pathologies associated with the bladder have wide impacts on society. Overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS) are chronic urological conditions characterized by pain, ...

Lee, Heejin, 1976-

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Self-assembled pentablock copolymers for selective and sustained gene delivery  

SciTech Connect (OSTI)

The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

Zhang, Bingqi

2011-05-15T23:59:59.000Z

182

Gaseous Hydrogen Delivery Breakout - Strategic Directions for...  

Broader source: Energy.gov (indexed) [DOE]

Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop...

183

A client management system for criminal justice referrals to drug abuse treatment  

E-Print Network [OSTI]

. These modalities included methadone maintenance (MM), outpatient drug-free (DF), therapeutic community (TC), and short-term detoxification (DT). In a review of findings in 1979, Sel ls described each of the four modalities. Methadone maintenance programs... over the years of research. Therapeutic communities are typically residential, drug-free programs offering 24-hour care and they concentrate on rehabilitation through resocialization of the addict toward more adaptive and productive pursuits. Drug...

Pate, Wayland Gordon

2012-06-07T23:59:59.000Z

184

Macro-System Model: A Federated Object Model for Cross-Cutting Analysis of Hydrogen Production, Delivery, Consumption and Associated Emissions; Preprint  

SciTech Connect (OSTI)

It is commonly accepted that the introduction of hydrogen as an energy carrier for light-duty vehicles involves concomitant technological development of infrastructure elements, such as production, delivery, and consumption, all associated with certain emission levels. To analyze these at a system level, the suite of corresponding models developed by the United States Department of Energy and involving several national laboratories is combined in one macro-system model (MSM). The macro-system model is being developed as a cross-cutting analysis tool that combines a set of hydrogen technology analysis models. Within the MSM, a federated simulation framework is used for consistent data transfer between the component models. The framework is built to suit cross-model as well as cross-platform data exchange and involves features of 'over-the-net' computation.

Ruth, M.; Diakov, V.; Goldsby, M. E.; Sa, T. J.

2010-12-01T23:59:59.000Z

185

Mental health care delivery system reform in Belgium: The challenge of achieving deinstitutionalisation whilst addressing fragmentation of care at the same time  

Science Journals Connector (OSTI)

Abstract Most mental health care delivery systems in welfare states currently face two major issues: deinstitutionalisation and fragmentation of care. Belgium is in the process of reforming its mental health care delivery system with the aim of simultaneously strengthening community care and improving integration of care. The new policy model attempts to strike a balance between hospitals and community services, and is based on networks of services. We carried out a content analysis of the policy blueprint for the reform and performed an ex-ante evaluation of its plan of operation, based on the current knowledge of mental health service networks. When we examined the policy's multiple aims, intermediate goals, suggested tools, and their articulation, we found that it was unclear how the new policy could achieve its goals. Indeed, deinstitutionalisation and integration of care require different network structures, and different modes of governance. Furthermore, most of the mechanisms contained within the new policy were not sufficiently detailed. Consequently, three major threats to the effectiveness of the reform were identified. These were: issues concerning the relationship between network structure and purpose, the continued influence of hospitals despite the goal of deinstitutionalisation, and the heterogeneity in the actual implementation of the new policy.

Pablo Nicaise; Vincent Dubois; Vincent Lorant

2014-01-01T23:59:59.000Z

186

Liposomes in Drug Targeting  

Science Journals Connector (OSTI)

Transport of drugs to target tissues, cells or subcellular organelles by the use of carrier systems is now a recognized useful method of improving drug selectivity. The types of carrier that have been proposed...

G. Gregoriadis

1980-01-01T23:59:59.000Z

187

Macro-System Model: A Federated Object Model for Cross-Cutting Analysis of Hydrogen Production, Delivery, Consumption and Associated Emissions: Preprint  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Macro-System Model: A Macro-System Model: A Federated Object Model for Cross-Cutting Analysis of Hydrogen Production, Delivery, Consumption and Associated Emissions Preprint M. Ruth and V. Diakov National Renewable Energy Laboratory M.E. Goldsby and T.J. Sa Sandia National Laboratories Presented at 4 th Transatlantic Infraday Conference Washington, D.C. November 5, 2010 Conference Paper NREL/CP-6A10-49544 December 2010 NOTICE The submitted manuscript has been offered by an employee of the Alliance for Sustainable Energy, LLC (Alliance), a contractor of the US Government under Contract No. DE-AC36-08GO28308. Accordingly, the US Government and Alliance retain a nonexclusive royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for US Government purposes.

188

Articulating feedstock delivery device  

DOE Patents [OSTI]

A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

Jordan, Kevin

2013-11-05T23:59:59.000Z

189

Electricity Delivery and Energy Reliability  

Broader source: Energy.gov (indexed) [DOE]

The Office of Electricity Delivery and Energy Reliability (OE) drives electric grid modernization and resiliency in the energy infrastructure while working to enable innovation across the energy sector, empowering American consumers, and securing our energy future. The OE mission and the leadership role OE plays in the energy industry directly support the President's effort to accelerate the transformation of America's energy system

190

Drug and radiation sensitivity testing of primary human tumor cells using the adhesive-tumor-cell culture system (ATCCS)  

SciTech Connect (OSTI)

In summary, the ATCCS is an efficient culture system which grows clonogenic cells from greater than 80% of human cancers. The ATCCS supports the growth of malignant cells from human cancers. The ATCCS shows classical drug and radiation survival curves which routinely achieve over 1 log of kill. The ATCCS has high CFE and permits sensitivity testing from small samples. Clinical correlations for the chemosensitivity assay were satisfactory. Radiosensitivity in vitro correlates with tumor histology.

Baker, F.L.; Spitzer, G.; Ajani, J.A.; Brock, W.A.

1988-01-01T23:59:59.000Z

191

Tools for integrating diagnosis in the design process An application to the Common Rail air and fuel delivery systems  

E-Print Network [OSTI]

in current generation automotive systems. However, the activities related to diagnosis (e.g., FMEA generation such as the diagnosability of the system being designed or the analysis of the FMEA (Failure Modes and Effects Analysis

192

drug safety monitoring (DSM)  

Science Journals Connector (OSTI)

Active surveillance for drug safety (in contrast to spontaneous report system); active surveillance systems usually have higher response rates than “passive” systems such as the yellow card programme; ? see also

Dr. med. Dr. phil. Gerhard Nahler

2009-01-01T23:59:59.000Z

193

Office of Electricity Delivery  

Energy Savers [EERE]

Office of Electricity Delivery and Energy Reliability Use of the NIST Cybersecurity Framework & DOE C2M2 CategorySubcategory CategorySubcategory CategorySubcategory Category...

194

The Integration of an Electro-Hydraulic Manipulator Arm into a Self-Contained Mobile Delivery System  

SciTech Connect (OSTI)

The Portable Articulated Arm Deployment System (PAADS) is a remotely controlled vehicle for delivering a tele-operated electro-hydraulic manipulator arm to a field-deployable location. The self-contained system includes a boom vehicle with long reach capability, an electro-hydraulic manipulator arm, closed circuit television (CCTV) systems, and onboard tools. On board power systems consist of a self-contained, propane-fired 8-KW generator and an air compressor for pneumatic tools. The generator provides the power to run the air compressor as well as power to operate the 110-VAC auxiliary lighting system for the video cameras. The separate control console can be located up to 500 ft from the vehicle. PAADS is a fully integrated system, containing all equipment required to perform complex field operations. Hydraulic integration of the manipulator arm into the vehicle hydraulic drive system was necessary to eliminate the tether management of hoses, which extended vehicle operating range, minimized hydraulic pressure losses, and provided the opportunity to go to a radio frequency (RF) control system in the future, thereby eliminating the control cable. This paper presents the key decision points during system development. Emphasis is placed on ease of operator control and not on an intelligent machine approach. In addition, emphasis is placed on the philosophy of remote operation based on sound principles of integration.

M. Borland; S. M. Berry

1999-04-01T23:59:59.000Z

195

The Integration of an Electro-hydraulic Manipulator Arm into a Self-contained Mobile Delivery System  

SciTech Connect (OSTI)

The Portable Articulated Arm Deployment System (PAADS) is a remotely controlled vehicle for delivering a tele-operated electro-hydraulic manipulator arm to a field deployable location. The self-contained system includes a boom vehicle with long reach capability, an electro-hydraulic manipulator arm, closed circuit television (CCTV) systems, and onboard tools. On board power systems consist of a self contained, propane fired 8 KW generator and an air compressor for pneumatic tools. The generator provides the power to run the air compressor as well as provide power to operate the 110 VAC auxiliary lighting system for the video cameras. The separate control console can be located up to 500 ft from the vehicle. PAADS is a fully integrated system, containing all equipment required to perform complex field operations. Hydraulic integration of the manipulator arm into the vehicle hydraulic drive system was necessary to eliminate the tether management of hoses, which extended vehicle operating range, minimized hydraulic pressure losses, and provided the opportunity to go to a radio frequency (RF) control system in the future, thereby eliminating the control cable. This paper presents the key decision points during system development. Emphasis is placed on ease of operator control and not on an intelligent machine approach. In addition, emphasis is placed on the philosophy of remote operation based on sound principles on integration.

Borland, Mark Wilson; Berry, Stephen Michael

1999-04-01T23:59:59.000Z

196

Liquid Hydrogen Delivery - Strategic Directions for Hydrogen...  

Broader source: Energy.gov (indexed) [DOE]

Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop Targets, barriers and...

197

Fuel Cell Technologies Office: Strategic Directions for Hydrogen Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Strategic Directions for Hydrogen Delivery Workshop Strategic Directions for Hydrogen Delivery Workshop The U.S. Department of Energy sponsored a Hydrogen Delivery Workshop in Washington, DC, May 7-8, 2003. Attendees included researchers, government officials, and industry members. A key element of the overall hydrogen energy infrastructure is the delivery system that moves the hydrogen from its point of production to an end-use device. The DOE's Fuel Cell Technologies Office will initiate, in fiscal year 2004, a research program targeted specifically at addressing hydrogen transportation and delivery. This special workshop was held to outline the future technology and research needs for developing cost-effective, reliable, and safe hydrogen delivery systems. The proceedings of the Hydrogen Delivery Workshop, which include the presentations and the recommendations of the four breakout groups, are available as Adobe Acrobat PDFs. Download Adobe Reader.

198

Prescription Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Prescription Drugs Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue Cross and Blue Shield of New Mexico (BCBSNM) health plan includes a prescription drug benefit administered by Prime Therapeutics. The cost of the prescription drug plan is included in your medical premiums. Coverage The co-pays for prescription drugs are based on a 3-tier prescription drug benefit. Co-payments are different for formulary or non-formulary, generic, or brand/preferred name. Review the BCBSNM Drug List (pdf) to find out which tier a specific drug falls under. Co-pays Prescription drug co-pays vary from plan to plan. 2013 EPO Summary of Benefits (pdf) 2013 PPO Summary of Benefits (pdf)

199

Gaseous Hydrogen Delivery Breakout  

E-Print Network [OSTI]

or reduce the likelihood of hydrogen embrittlement Test existing high strength steel alloys for use in largeGaseous Hydrogen Delivery Breakout Strategic Directions for Hydrogen Delivery Workshop May 7 compression. Safety, integrity, reliability: Metal embrittlement, no H2 odorant, low ignition energy

200

Hydrogen Delivery Liquefaction & Compression  

E-Print Network [OSTI]

Hydrogen Delivery Liquefaction & Compression Raymond Drnevich Praxair - Tonawanda, NY Strategic Initiatives for Hydrogen Delivery Workshop - May 7, 2003 #12;2 Agenda Introduction to Praxair Hydrogen Liquefaction Hydrogen Compression #12;3 Praxair at a Glance The largest industrial gas company in North

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

College of Electricity Delivery and Energy Reliability | Department of  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery and Energy Reliability Electricity Delivery and Energy Reliability College of Electricity Delivery and Energy Reliability College of Electricity Delivery and Energy Reliability Vision OE recognizes that our Nation's sustained economic prosperity, quality of life, and global competitiveness depend on access to an abundance of secure, reliable, and affordable energy resources. Through a mix of technology and policy solutions, we will address the changing dynamics and uncertainties in which the electric system will operate. We will leverage effective partnerships, solid research, and best practices to address diverse interests in achieving economic, societal, and environmental objectives. Resources Explore the following topics at OE's College of Electricity Delivery and Energy Reliability:

202

Hydrogen Delivery Options and Issues  

Broader source: Energy.gov (indexed) [DOE]

Eastman Chemical Ferco AEP Thermochem Entergy GE Framatome Stuart Energy APCi Chevron Praxair Exxonmobil BOC BP H2A Delivery Goals * Develop spreadsheet database on delivery...

203

Analysis of the Texas A&M University System's Construction Project Delivery Method Performance: CMAR and CSP  

E-Print Network [OSTI]

method of competitive sealed proposal (CSP) in the construction of higher educational facilities. In a study of 33 projects constructed by The Texas A&M University System, 19 procured using CMAR and 14 procured using CSP, observed results show a reduction...

Neidert, Andrew

2012-10-19T23:59:59.000Z

204

128 IEEE Transactionson Power Delivery, Vol. 9, No. 1, January 1994 SUNBURST-A Networkof GIC Monitoring Systems  

E-Print Network [OSTI]

Monitoring Systems Richard T. Byerly Electric Research Washington, DC StateCollege, PA Robert L.Lesher Joseph W. Porter Member, IEEE Fellow, IEEE Fellow, IEEE ElectricResearch Electric Power and Management, Inc. Research Institute and Management, Inc. StateCollege, PA Abstract The Electric Power Research Institute has

Schrijver, Karel

205

IEEE TRANSACTIONS ON POWER DELIVERY, VOL. 17, NO. 4, OCTOBER 2002 1113 A Benchmark System for Digital Time-Domain  

E-Print Network [OSTI]

of power electronic-based apparatus at various voltage levels in electric energy systems is becoming in- creasingly widespread due to rapid progress in power electronic technology. The static synchronous that is well above the fundamental frequency of the ac supply. The capacitor voltage is at least equal

Lehn, Peter W.

206

Gas delivery system and beamline studies for the test beam facility of the Collider Detector at Fermilab  

E-Print Network [OSTI]

, resolution improves. F. Muon Detectors Muon detectors include the Central Muon Detector and the Forward Muon De- tector. The Central Muon Detector lies outside the central hadron calorimeter and provides muon detection over the range 55' & 6 & 125... at Fermilab B. Small Angle Counters C. The Magnet D. Tracking E. . Calorimetry F. Muon Detectors G. What the Particles Produced See H. Data Acquisition System I. Trigger J. Initial Runs at CDF 10 15 15 16 17 18 III CDF GAS CALORIMETRY...

Franke, Henry Gerhart

1987-01-01T23:59:59.000Z

207

In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug-delivery systems and tailor-made medicine  

Science Journals Connector (OSTI)

The recent advances in nanotechnology have a great potential to improve the ... wavelength. Future innovation in cancer imaging by nanotechnology and novel measurement technology will provide great ... in basic m...

Motohiro Takeda; Hiroshi Tada; Hideo Higuchi; Yoshio Kobayashi…

2008-04-01T23:59:59.000Z

208

Delivery of Boron-10 for Neutron Capture Therapy by Means of Monoclonal Antibody - Starburst Dendrimer Immunoconjugates  

Science Journals Connector (OSTI)

The use of monoclonal antibodies (MoAbs) for the delivery of radionuclides, drugs and toxins for therapeutic purposes has been the subject of intensive investigation over the past decade. A few investigators, inc...

Rolf F. Barth; Albert H. Soloway…

1992-01-01T23:59:59.000Z

209

Clinical Manifestations of Allergic Diseases: Drug Hypersensitivity  

Science Journals Connector (OSTI)

Drug allergies are those adverse drug reactions that are mediated by the specific immune system. Primary sensitization may involve T-cells alone or both T and B-cells with consecutive production of drug specif...

Benno Schnyder; Werner J. Pichler

2009-01-01T23:59:59.000Z

210

VIA EMAIL DELIVERY  

Broader source: Energy.gov (indexed) [DOE]

VIA EMAIL DELIVERY VIA EMAIL DELIVERY March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability U.S. Department of Energy 1000 Independence Avenue SW Washington, D.C. 20585 Lamont.Jackson@hq.doe.gov Re: Request for Information, OE Docket No. RRTT-IR-001, Rapid Response Team for Transmission Dear Mr. Jackson: TransWest Express LLC (TransWest) appreciates the opportunity to respond to the Department of Energy's questions related to permitting transmission lines, as outlined in the February 27, 2012, Federal Register notice. Per your request, the role of our company in the electric sector is as follows. TransWest is an independent transmission developer that is focused on permitting and developing the TransWest Express Transmission Project (TWE Project). The TWE Project is one of the seven

211

Hydrogen Delivery Roadmap  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delivery Delivery Technical Team Roadmap June 2013 This roadmap is a document of the U.S. DRIVE Partnership. U.S. DRIVE (United States Driving Research and Innovation for Vehicle efficiency and Energy sustainability) is a voluntary, non-binding, and nonlegal partnership among the U.S. Department of Energy; United States Council for Automotive Research (USCAR), representing Chrysler Group LLC, Ford Motor Company, and General Motors; Tesla Motors; five energy companies - BPAmerica, Chevron Corporation, Phillips 66 Company, ExxonMobil Corporation, and Shell Oil Products US; two utilities - Southern California Edison and DTE Energy; and the Electric Power Research Institute (EPRI). The Hydrogen Delivery Technical Team is one of 12 U.S. DRIVE technical teams ("tech teams") whose

212

Understanding barriers to efficient nucleic acid delivery with bioresponsive block copolymers  

E-Print Network [OSTI]

The delivery of nucleic acids has the potential to revolutionize medicine by allowing previously untreatable diseases to be clinically addressed. Viral delivery systems have been held back by immunogenicity and toxicity ...

Bonner, Daniel Kenneth

2012-01-01T23:59:59.000Z

213

Energy Department Announces up to $4 Million to Advance Hydrogen Delivery Technology Development  

Broader source: Energy.gov [DOE]

Up to $4 million will be made available for projects focused on innovative hydrogen delivery materials, components, and systems needed to establish the technical and cost feasibility for renewable and low carbon hydrogen delivery.

214

Modeling hierarchically structured nanoparticle/diblock copolymer systems  

E-Print Network [OSTI]

in energy production and conversion, drug delivery, and tissue growth, just to mention a few.1,2 In order in a variety of applications, including ­ but not limited to ­ microelectronics, energy storage and conversion nanocomposites is determined by a number of factors, some strictly connected to the nature of the system (i

Lisal, Martin

215

Hydrogen Delivery - Basics | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Delivery Hydrogen Delivery - Basics Hydrogen Delivery - Basics Photo of light-duty vehicle at hydrogen refueling station. Infrastructure is required to move hydrogen from the...

216

Gaseous Hydrogen Delivery Breakout- Strategic Directions for Hydrogen Delivery Workshop  

Broader source: Energy.gov [DOE]

Targets, barriers and research and development priorities for gaseous delivery of hydrogen through hydrogen and natural gas pipelines.

217

Hydrogen Delivery- Current Technology  

Broader source: Energy.gov [DOE]

Hydrogen is transported from the point of production to the point of use via pipeline, over the road in cryogenic liquid trucks or gaseous tube trailers, or by rail or barge. Read on to learn more about current hydrogen delivery and storage technologies.

218

Hydrogen Storage Technologies Hydrogen Delivery  

E-Print Network [OSTI]

Hydrogen Storage Technologies Roadmap Hydrogen Delivery Technical Team Roadmap June 2013 #12;This.................................................................................. 13 6. Hydrogen Storage). The Hydrogen Delivery Technical Team is one of 12 U.S. DRIVE technical teams ("tech teams") whose mission

219

Experimental and computational investigations of therapeutic drug release from biodegradable poly(lactide-co-glycolide) (plg) microspheres  

E-Print Network [OSTI]

The need to tailor release-rate profiles from polymeric microspheres remains one of the leading challenges in controlled drug delivery. Microsphere size, which has a significant effect on drug release rate, can potentially be varied to design a...

Berchane, Nader Samir

2009-05-15T23:59:59.000Z

220

Hydrogen Delivery Liquefaction and Compression  

Broader source: Energy.gov [DOE]

Hydrogen Delivery Liquefaction and Compression - Overview of commercial hydrogen liquefaction and compression and opportunities to improve efficiencies and reduce cost.

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 2009/109/109/109/10 Annual Delivery Report  

E-Print Network [OSTI]

STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 2009/109/109/109/10 0 Annual Delivery Report 2009/10 August 2010 #12;STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery

222

Comparative Evaluation of Capsular Polysaccharide-Specific IgM and IgG Antibodies and F(ab?)2 and Fab Fragments as Delivery Vehicles for Radioimmunotherapy of Fungal Infection  

Science Journals Connector (OSTI)

...the best delivery vehicle for radioimmunotherapy...used as delivery vehicles for radionuclides...Latex-Crypto antigen detection system (2), which is...Antibodies as delivery vehicles for radioimmunotherapy...components of the immune system in vitro and during...

Ekaterina Dadachova; Ruth A. Bryan; Xianchun Huang; Geraldina Ortiz; Tiffany Moadel; and Arturo Casadevall

2007-09-15T23:59:59.000Z

223

Magnetically-triggered Nanocomposite Membranes: a Versatile Platform for Triggered Drug Release  

E-Print Network [OSTI]

Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field. The dose of drug delivered can be tuned by engineering the phase transition temperature of the nanogel, the loading of nanogels in the membrane, and the membrane thickness, allowing for the delivery of drugs over several orders of magnitude of release rates. The zero-order kinetics of drug release through the membranes permit drug doses from a specific device to be tuned according to the duration of the magnetic field. Drugs over a broad range of molecular weights (500-40,000 Da) can be delivered by the same membrane device. Membrane-to-membrane and cycle-to-cycle reproducibility is demonstrated, suggesting the general utility of these membranes for drug delivery.

Todd Hoare; Brian P. Timko; Jesus Santamaria; Gerardo F. Goya; Silvia Irusta; Debora Lin; Samantha Lau; Robert Langer; Daniel S. Kohane

2011-06-27T23:59:59.000Z

224

Office of Electricity Delivery  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery Electricity Delivery and Energy Reliability Smart Grid R&D Program DOE Microgrid Workshop Report August 30-31, 2011 San Diego, California ii Acknowledgment The U.S. Department of Energy (DOE) would like to acknowledge the support provided by the organizations represented on the workshop planning committee in developing the workshop process and sessions. The preparation of this workshop report was coordinated by Energy & Environmental Resources Group, LLC (E2RG). The report content is based on the workshop session discussions, with session summary descriptions taken from the report-out presentations by individual teams during the closing plenary. Contributions to this report by all workshop participants, via expressed viewpoints during the

225

Hydrogen Delivery Infrastructure Option Analysis  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hydrogen Delivery Infrastructure Hydrogen Delivery Infrastructure Option Analysis Option Analysis DOE and FreedomCAR & Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop January 25, 2005 Washington DC This presentation does not contain any proprietary or confidential information Tan-Ping Chen Nexant Jim Campbell Bhadra Grover Air Liquide Stefan Unnasch TIAX Glyn Hazelden GTI Graham Moore Chevron Matt Ringer NREL Ray Hobbs Pinnacle West 2 Presentation Outline Project Background Knowledge Collected and Preliminary Results for Each Delivery Option Summary of Observations Next Step Project Background Project Background 4 Delivery Options Option 1* GH delivery by new pipelines Option 2 Converting NG/oil pipelines for GH delivery Option 3 Blending GH into NG pipelines Option 4* GH tube trailers

226

Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery  

Science Journals Connector (OSTI)

...realizing the potential of genetic medicine. As future therapeutics will increasingly...nano-carriers for drug delivery. Nanotechnology 16, S484-S491. ( doi:10...Williams, D. A. , and C. Baum 2003 Medicine. Gene therapy-new challenges...

2010-01-01T23:59:59.000Z

227

Vectren Energy Delivery of Indiana (Electric) - Commercial New Construction  

Broader source: Energy.gov (indexed) [DOE]

Vectren Energy Delivery of Indiana (Electric) - Commercial New Vectren Energy Delivery of Indiana (Electric) - Commercial New Construction Rebates (Indiana) Vectren Energy Delivery of Indiana (Electric) - Commercial New Construction Rebates (Indiana) < Back Eligibility Commercial Fed. Government Industrial Local Government Nonprofit State Government Savings Category Home Weatherization Commercial Weatherization Heating & Cooling Commercial Heating & Cooling Cooling Other Heat Pumps Appliances & Electronics Commercial Lighting Lighting Windows, Doors, & Skylights Maximum Rebate Custom/HVAC Systems: $100,000 or 50% of the total project cost Incentive cannot buy down project below 1.5 years payback. Program Info State Indiana Program Type Utility Rebate Program Rebate Amount HVAC Systems (New Construction): $0.12/kWh reduced

228

Optimal Placement of Wind Power Plants for Delivery Loss Minimization  

Science Journals Connector (OSTI)

In this chapter we investigate how to minimize power delivery losses in the distribution system on ... We show that strategically placing and utilizing new wind power plants can lead to significant loss reduction...

Masoud Honarvar Nazari

2013-01-01T23:59:59.000Z

229

Office of Electricity Delivery and Energy Reliability  

Broader source: Energy.gov (indexed) [DOE]

Comments of Cisco Systems to Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Department of Energy in Response to Request for Information: Addressing Policy and Logistical Challenges to Smart Grid Implementation Issued September 13, 2010 FR Doc. 2010-23251 November 30, 2010 Cisco Systems provides these Comments in response to the Request for Information ("RFI") issued by the Office of Electricity Delivery and Energy Reliability of the Department of Energy ("DOE") on September 13, 2010. The RFI seeks information across a broad range of topics, but also requests that commenters be "concise," and provide "facts and concrete recommendations that can augment the general knowledge." 1 1. Interoperability Standards and the Smart Grid

230

Antiretroviral drugs  

Science Journals Connector (OSTI)

In October 2010, it will be exactly 25 years ago that the first antiretroviral drug, AZT (zidovudine, 3?-azido-2?,3?-dideoxythymidine), was described. It was the first of 25 antiretroviral drugs that in the past 25 years have been formally licensed for clinical use. These antiretroviral drugs fall into seven categories [nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), fusion inhibitors (FIs), co-receptor inhibitors (CRIs) and integrase inhibitors (INIs). The \\{INIs\\} (i.e. raltegravir) represent the most recent advance in the search for effective and selective anti-HIV agents. Combination of several anti-HIV drugs [often referred to as highly active antiretroviral therapy (HAART)] has drastically altered AIDS from an almost uniformly fatal disease to a chronic manageable one.

Erik De Clercq

2010-01-01T23:59:59.000Z

231

Cytoplasmic transduction peptide (CTP): New approach for the delivery of biomolecules into cytoplasm in vitro and in vivo  

SciTech Connect (OSTI)

The protein transduction domain (PTD) of HIV-1 TAT has been extensively documented with regard to its membrane transduction potential, as well as its efficient delivery of biomolecules in vivo. However, the majority of PTD and PTD-conjugated molecules translocate to the nucleus rather than to the cytoplasm after transduction, due to the functional nuclear localization sequence (NLS). Here, we report a cytoplasmic transduction peptide (CTP), which was deliberately designed to ensure the efficient cytoplasmic delivery of the CTP-fused biomolecules. In comparison with PTD, CTP and its fusion partners exhibited a clear preference for cytoplasmic localization, and also markedly enhanced membrane transduction potential. Unlike the mechanism underlying PTD-mediated transduction, CTP-mediated transduction occurs independently of the lipid raft-dependent macropinocytosis pathway. The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery. In in vivo trafficking studies, CTP-fused {beta}-gal exhibited unique organ tropisms to the liver and lymph nodes when systemically injected into mice, whereas PTD-{beta}-gal exhibited no such tropisms. Taken together, our findings implicate CTP as a novel delivery peptide appropriate for (i) molecular targeting to cytoplasmic compartments in vitro, (ii) the development of class I-associated CTL vaccines, and (iii) special drug delivery in vivo, without causing any untoward effects on nuclear genetic material.

Kim, Daeyou [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of); Department of Genetic Engineering, Youngdong University, Youngdong, Chungbuk (Korea, Republic of); Jeon, Choonju [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of); Kim, Jeong-Hwan [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of); Kim, Mi-Seon [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of); Yoon, Cheol-Hee [Department of Biological Science, Sungkyunkwan University, Suwon, Gyeonggido (Korea, Republic of); Choi, In-Soo [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of); College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul (Korea, Republic of); Kim, Sung-Hoon [Graduate School of East-West Medicine, Kyunghee University, Yongin, Gyeonggido (Korea, Republic of); Bae, Yong-Soo [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of) and Department of Biological Science, Sungkyunkwan University, Suwon, Gyeonggido (Korea, Republic of)]. E-mail: ysbae04@skku.edu

2006-05-01T23:59:59.000Z

232

Delivery Analysis | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

(1998) Home About the Fuel Cell Technologies Office Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells Technology Validation Manufacturing Safety, Codes, and...

233

Targeted Nanogels: A Versatile Platform for Drug Delivery to Tumors  

Science Journals Connector (OSTI)

...a prime operation platform for implementation of chemical reactions (12-15...operation of complicated chemical (19, 20) and biological...in stand-alone platforms. PDMS devices are...devices coupled to chemical and physical changes...

Eric A. Murphy; Bharat K. Majeti; Rajesh Mukthavaram; Lisette M. Acevedo; Leo A. Barnes; and David A. Cheresh

2011-06-01T23:59:59.000Z

234

Applications of triazine chemistry: education, remediation, and drug delivery  

E-Print Network [OSTI]

and its effect on the environment and society. The modification of chitosan for herbicide remediation has been accomplished using triazine chemistry, as well. Treatment of chitosan iteratively with cyanuric chloride followed by piperazine produces...

Hatfield, Susan Elizabeth

2009-05-15T23:59:59.000Z

235

Glutamate-Leucine Block Copolypeptides for Drug Delivery  

E-Print Network [OSTI]

310 -b-poly(acrylic acid) 36 (PS 310 -b-PAA 36 ) vesicles.Since PS 310 -b- PAA 36 , which consists of a negatively-properties to the PS 310 -b-PAA 36 vesicle bilayer. They

Lee, Brian Sangwoo

2014-01-01T23:59:59.000Z

236

Fault-Tolerant Reliable Delivery of Messages in Distributed Publish/Subscribe Shrideep Pallickara, Hasan Bulut and Geoffrey Fox  

E-Print Network [OSTI]

Fault-Tolerant Reliable Delivery of Messages in Distributed Publish/Subscribe Systems Shrideep)@indiana.edu Abstract Reliable delivery of messages is an important problem that needs to be addressed in distributed systems. In this paper we briefly describe our basic strategy to enable reliable delivery of messages

237

Electricity Delivery and Energy Reliability | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery and Energy Reliability Electricity Delivery and Energy Reliability information about the delivery of electricity and energy reliability Electricity Delivery...

238

Towards a framework for business model innovation in health care delivery in developing countries  

Science Journals Connector (OSTI)

Ramon Castano highlights healthcare delivery systems in developing countries need innovative business solutions to address current shortcomings, and proposes six buiding blocks which can be implemented.

Ramon Castano

2014-12-02T23:59:59.000Z

239

Capital Projects Delivery Procedures Manual  

E-Print Network [OSTI]

1 Capital Projects Delivery Procedures Manual September 4, 2008 Office of the CFO #12;2 Page I of the Capital Budget 11 B. Budget Approval 12 C. Setting Up Capital Projects 13 III. Procedures for Design ­ Office of the Chief Financial Officer Financial Policies and Procedures for the Capital Project Delivery

Alpay, S. Pamir

240

Hydrogen Production and Delivery Research  

SciTech Connect (OSTI)

In response to DOE's Solicitation for Grant Applications DE-PS36-03GO93007, 'Hydrogen Production and Delivery Research', SRI International (SRI) proposed to conduct work under Technical Topic Area 5, Advanced Electrolysis Systems; Sub-Topic 5B, High-Temperature Steam Electrolysis. We proposed to develop a prototype of a modular industrial system for low-cost generation of H{sub 2} (<$2/kg) by steam electrolysis with anodic depolarization by CO. Water will be decomposed electrochemically into H{sub 2} and O{sub 2} on the cathode side of a high-temperature electrolyzer. Oxygen ions will migrate through an oxygen-ion-conductive solid oxide electrolyte. Gas mixtures on the cathode side (H{sub 2} + H{sub 2}O) and on the anode side (CO + CO{sub 2}) will be reliably separated by the solid electrolyte. Depolarization of the anodic process will decrease the electrolysis voltage, and thus the electricity required for H{sub 2} generation and the cost of produced H{sub 2}. The process is expected to be at least 10 times more energy-efficient than low-temperature electrolysis and will generate H{sub 2} at a cost of approximately $1-$1.5/kg. The operating economics of the system can be made even more attractive by deploying it at locations where waste heat is available; using waste heat would reduce the electricity required for heating the system. Two critical targets must be achieved: an H{sub 2} production cost below $2/kg, and scalable design of the pilot H{sub 2} generation system. The project deliverables would be (1) a pilot electrolysis system for H{sub 2} generation, (2) an economic analysis, (3) a market analysis, and (4) recommendations and technical documentation for field deployment. DOE was able to provide only 200K out of 1.8M (or about 10% of awarded budget), so project was stopped abruptly.

Iouri Balachov, PhD

2007-10-15T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Delivery of neuroactive peptide drugs to the brain via intranasal delivery  

E-Print Network [OSTI]

presents a human plasma stability assay on a racemic lipoamino acid Leu-enkephalin derivative. Methods Caco-2 Permeability assay: Caco-2 cells form tight monolayer structures when seeded on to polycarbonate filters. To assess permeability, a 200 ?M... is the initial concentration in the donor chamber. Plasma stability assay: This assay was performed by mixing 300?L of a solution of C8Laa- Enkephalin (1mg/mL) with 300?L of plasma prewarmed at 37.5????C. At chosen time points, 50?L of the plasma mixture...

Cros, C. D.; Toth, I.; Blanchfield, J.

2006-10-27T23:59:59.000Z

242

Numerical simulation investigations in weapon delivery probabilities .  

E-Print Network [OSTI]

??The study of weapon delivery probabilities has historically been focused around analytical solutions and approximations for weapon delivery accuracy and effectiveness calculations. With the relatively… (more)

Peterson, Kristofer A.

2008-01-01T23:59:59.000Z

243

Cryocompressed Hydrogen Storage and Liquid Delivery  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Cryocompressed Hydrogen Storage & Liquid Delivery Jacob Leachman, Ph.D. Assistant Professor DOE H 2 Transmission & Delivery Workshop 2262014 H Y P E R H drogen roperties for...

244

ELECTRICITY DELIVERY AND ENERGY RELIABILITY Appropriation Overview  

Broader source: Energy.gov (indexed) [DOE]

ELECTRICITY DELIVERY AND ENERGY RELIABILITY Appropriation Overview Electricity Delivery and Energy Reliability (OE) drives electric grid modernization and resiliency in the energy...

245

A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles  

E-Print Network [OSTI]

The use of polymeric nanoparticles as drug delivery devices is becoming increasingly prevalent in a variety of therapeutic applications. Despite their widespread clinical use, the factors influencing the release profiles ...

Eavarone, David A.

246

Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating  

E-Print Network [OSTI]

Electrically triggered drug delivery represents an attractive option for actively and remotely controlling the release of a therapeutic from an implantable device (e.g., a “pharmacy-on-a-chip”). Here we report the fabrication ...

Schmidt, Daniel J.

247

Prolonged Serum Half-Life of Antineoplastic Drugs by Incorporation into the Low Density Lipoprotein  

Science Journals Connector (OSTI)

...cells. J. Supramol. Struct., 10: 467-478, 1979. Shaw. J. M.. Shaw. K. V., Yanovich, S., Iwanik. M., Futch, W. S., Rosowsky, A., and Schook, L. B. Delivery of lipophilic drugs using lipoproteins. Ann. NY Acad. Sci...

P. Chris de Smidt and Theo J. C. van Berkel

1990-12-01T23:59:59.000Z

248

Waste feed delivery planning at Hanford  

SciTech Connect (OSTI)

The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades.

Certa, Paul J.; West, Elizha B.; Rodriguez, Juissepp S.; Hohl, Ted M.; Larsen, Douglas C.; Ritari, Jaakob S.; Kelly, James W.

2013-01-10T23:59:59.000Z

249

Waste Feed Delivery Planning at Hanford - 13232  

SciTech Connect (OSTI)

The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades. (authors)

Certa, Paul J.; Hohl, Ted M.; Kelly, James W.; Larsen, Douglas C.; West, Elizha B.; Ritari, Jaakob S.; Rodriguez, Juissepp S. [Washington River Protection Solutions, LLC, P.O. 850, Richland, WA 99352 (United States)] [Washington River Protection Solutions, LLC, P.O. 850, Richland, WA 99352 (United States)

2013-07-01T23:59:59.000Z

250

Electricity Delivery and Energy Reliability PROGRAM DESCRIPTION  

Broader source: Energy.gov (indexed) [DOE]

2 2 Electricity Delivery and Energy Reliability PROGRAM DESCRIPTION The Office of Electricity Delivery and Energy Reliability (OE) leads national efforts to modernize the electric grid, enhance security and reliability of energy infrastructure, and facilitate recovery from disruptions to the energy supply. As stated in the President's A Policy Framework for the 21 st Century Grid, a smarter, modernized electric grid is fundamental to transforming the Nation's energy system and securing US leadership in a clean energy future. OE supports activities that enable innovation across the energy sector, empower American consumers, and secure our energy future. OE consists of three programs: Research and Development; Permitting, Siting and Analysis; and Infrastructure Security and Energy Restoration.

251

Fiber Delivery of mid-IR lasers  

SciTech Connect (OSTI)

Fiber optics for the visible to near infrared (NIR) wavelength regimes (i.e. = 0.42 {mu}m) have proven to be extremely useful for a myriad of applications such as telecommunications, illumination, and sensors because they enable convenient, compact, and remote delivery of laser beams. Similarly, there is a need for fiber optics operating at longer wavelengths. For example, systems operating in the mid-IR regime (i.e., = 314 {mu}m) are being developed to detect trace molecular species with far-reaching applications, such as detecting explosives on surfaces, pollutants in the environment, and biomarkers in the breath of a patient. Furthermore, with the increasing availability of quantum cascade lasers (QCLs) which are semiconductor lasers that operate in the mid-IR regime additional uses are rapidly being developed. Here, we describe the development of hollow-core fibers for delivery of high-quality mid-IR laser beams across a broad spectral range.

Kriesel, J.M.; Gat, N.; Bernacki, Bruce E.; Myers, Tanya L.; Bledt, Carlos M.; Harrington, James P.

2011-08-24T23:59:59.000Z

252

Office of Electricity Delivery And Energy Reliability To Hold Technical  

Broader source: Energy.gov (indexed) [DOE]

Office of Electricity Delivery And Energy Reliability To Hold Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission February 5, 2009 - 10:57am Addthis On March 4, 2009, the Department of Energy's Office of Electricity Delivery and Energy Reliability (OE) will conduct a technical conference in the Washington, DC area to discuss the design of future electric transmission. The technical conference will discuss the likely demand for future electric transmission and whether the development of conceptual alternative extra high voltage (EHV) systems would assist generation developers, State energy policy officials, utility planners, and other

253

Hydrogen Delivery Infrastructure Options Analysis  

Fuel Cell Technologies Publication and Product Library (EERE)

This report, by the Nexant team, documents an in-depth analysis of seven hydrogen delivery options to identify the most cost-effective hydrogen infrastructure for the transition and long term. The pro

254

Hydrogen Delivery Infrastructure Option Analysis  

Broader source: Energy.gov (indexed) [DOE]

pipes - Operating pressure is 35% rather than typical 72% of allowable stress 20-25% less energy delivered (excluding pressure de-rating): Overall, delivery capacity is de-rated by...

255

Hydrogen Distribution and Delivery Infrastructure  

Fuel Cell Technologies Publication and Product Library (EERE)

This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challen

256

Hydrogen Delivery Technology Roadmap, November 2005  

Fuel Cell Technologies Publication and Product Library (EERE)

Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

257

Investigation of Volume of Fluids (VOF) Method and System Models for Design of Microfluidic Ink Delivery Apparatus for Dip Pen Nanolithography (DPN)  

E-Print Network [OSTI]

Investigation of Volume of Fluids (VOF) Method and System Models for Design of Microfluidic Ink and manufacture of commercial microfluidic systems called "InkwellsTM". In this study VOF method was used sequence of flow in the different parts of the microfluidic network. Keywords: lab-on-chip, micro

Banerjee, Debjyoti

258

GERMAN REFORMS AFFECT DRUG R&D  

Science Journals Connector (OSTI)

Under the national health care system, insurers pay for consumers' prescription drugs and get a 6% rebate from manufacturers to help contain costs; the remainder ... ...

PATRICIA SHORT

2003-09-01T23:59:59.000Z

259

Hydrogen Delivery Options and Issues  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Options and Issues Options and Issues Mark Paster DOE August, 2006 Scope * From the end point of central or distributed production (300 psi H2) to and including the dispenser at a refueling station or stationary power site - GH2 Pipelines and Trucks, LH2 Trucks, Carriers <$1.00/kg of Hydrogen by 2017 Hydrogen Delivery H2 Delivery Current Status * Technology - GH2 Tube Trailers: ~340 kg, ~2600 psi - LH2 Trucks: ~3900 kg - Pipelines: up to 1500 psi (~630 miles in the U.S.) - Refueling Site Operations (compression, storage dispensing): Demonstration projects * Cost (Does NOT include refueling Site Operations) - Trucks: $4-$12/kg - Pipeline: <$2/kg H2A Analysis * Consistent, comparable, transparent approach to hydrogen production and delivery cost analysis * Excel spreadsheet tools with common economic

260

Comments of Oncor Electric Delivery Company LLC | Department...  

Broader source: Energy.gov (indexed) [DOE]

Comments of Oncor Electric Delivery Company LLC Comments of Oncor Electric Delivery Company LLC Comments of Oncor Electric Delivery Company LLC on Implementing the National...

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Agenda for the Hydrogen Delivery and Onboard Storage Analysis...  

Broader source: Energy.gov (indexed) [DOE]

Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and...

262

Radioisotope Power System Delivery, Ground Support and Nuclear Safety Implementation: Use of the Multi-Mission Radioisotope Thermoelectric Generator for the NASA's Mars Science Laboratory  

SciTech Connect (OSTI)

Radioisotope power systems have been used for over 50 years to enable missions in remote or hostile environments. They are a convenient means of supplying a few milliwatts up to a few hundred watts of useable, long-term electrical power. With regard to use of a radioisotope power system, the transportation, ground support and implementation of nuclear safety protocols in the field is a complex process that requires clear identification of needed technical and regulatory requirements. The appropriate care must be taken to provide high quality treatment of the item to be moved so it arrives in a condition to fulfill its missions in space. Similarly it must be transported and managed in a manner compliant with requirements for shipment and handling of special nuclear material. This presentation describes transportation, ground support operations and implementation of nuclear safety and security protocols for a radioisotope power system using recent experience involving the Multi-Mission Radioisotope Thermoelectric Generator for National Aeronautics and Space Administration’s Mars Science Laboratory, which launched in November of 2011.

S.G. Johnson; K.L. Lively; C.C. Dwight

2014-07-01T23:59:59.000Z

263

A P2P VIDEO DELIVERY NETWORK (P2P-VDN) Kien Nguyen, Thinh Nguyen  

E-Print Network [OSTI]

A P2P VIDEO DELIVERY NETWORK (P2P-VDN) Kien Nguyen, Thinh Nguyen School of EECS Oregon State University kovchegy@science.oregonstate.edu ABSTRACT Current video streaming and storage systems such as You- per describes a Peer-to-Peer Video Delivery Network (P2P- VDN) that provides both performance

Kovchegov, Yevgeniy

264

California Natural Gas International Deliveries (Million Cubic...  

U.S. Energy Information Administration (EIA) Indexed Site

Deliveries (Million Cubic Feet) California Natural Gas International Deliveries (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9...

265

Delivery Tech Team | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Delivery Tech Team Delivery Tech Team Presentation by 02-Parks to DOE Hydrogen Pipeline R&D Project Review Meeting held January 5-6, 2005 at Oak Ridge National Laboratory in Oak...

266

A planning and delivery study of a rotational IMRT technique with burst delivery  

SciTech Connect (OSTI)

Purpose: A novel rotational IMRT (rIMRT) technique using burst delivery (continuous gantry rotation with beam off during MLC repositioning) is investigated. The authors evaluate the plan quality and delivery efficiency and accuracy of this dynamic technique with a conventional flat 6 MV photon beam. Methods: Burst-delivery rIMRT was implemented in a planning system and delivered with a 160-MLC linac. Ten rIMRT plans were generated for five anonymized patient cases encompassing head and neck, brain, prostate, and prone breast. All plans were analyzed retrospectively and not used for treatment. Among the varied plan parameters were the number of optimization points, number of arcs, gantry speed, and gantry angle range (alpha) over which the beam is turned on at each optimization point. Combined rotational/step-and-shoot rIMRT plans were also created by superimposing multiple-segment static fields at several optimization points. The rIMRT trial plans were compared with each other and with plans generated using helical tomotherapy and VMAT. Burst-mode rotational IMRT plans were delivered and verified using a diode array, ionization chambers, thermoluminescent dosimeters, and film. Results: Burst-mode rIMRT can achieve plan quality comparable to helical tomotherapy, while the former may lead to slightly better OAR sparing for certain cases and the latter generally achieves slightly lower hot spots. Few instances were found in which increasing the number of optimization points above 36, or superimposing step-and-shoot IMRT segments, led to statistically significant improvements in OAR sparing. Using an additional rIMRT partial arc yielded substantial OAR dose improvements for the brain case. Measured doses from the rIMRT plan delivery were within 4% of the plan calculation in low dose gradient regions. Delivery time range was 228-375 s for single-arc rIMRT 200-cGy prescription with a 300 MU/min dose rate, comparable to tomotherapy and VMAT. Conclusions: Rotational IMRT with burst delivery, whether combined with static fields or not, yields clinically acceptable and deliverable treatment plans.

Kainz, Kristofer; Chen, Guang-Pei; Chang, Yu-Wen; Prah, Douglas; Sharon Qi, X.; Shukla, Himanshu P.; Stahl, Johannes; Allen Li, X. [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States); Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado 80045 (United States); Siemens Oncology Care Systems, Concord, California 94520 (United States); Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States)

2011-09-15T23:59:59.000Z

267

Strategic Directions for Hydrogen Delivery Workshop Proceedings  

Broader source: Energy.gov [DOE]

Proceedings from the Strategic Directions for Hydrogen Delivery Workshop held May 7-8, 2003 in Washington, DC. Author: Energetics

268

Delivery and Hedging Delivery ties the futures price to the spot price.  

E-Print Network [OSTI]

Delivery and Hedging · Delivery ties the futures price to the spot price. · On the delivery date, the settlement price of the futures contract is determined by the spot price. · Hence, when the delivery period is reached, the futures price should be very close to the spot price. · Changes in futures prices usually

Lyuu, Yuh-Dauh

269

Energy Tradeoffs among Content Delivery Architectures  

E-Print Network [OSTI]

Energy Trade­offs among Content Delivery Architectures Anja Feldmann Andreas Gladisch Mario Kind to incorporate var­ ious home devices such as set­top boxes into content delivery architectures using the Peer­to­Peer (P2P) paradigm. The hope is to enhance the efficiency of content delivery, e.g., in terms

Smaragdakis, Georgios

270

Waste Feed Delivery Environmental Permits and Approvals Plan  

SciTech Connect (OSTI)

This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches.

TOLLEFSON, K.S.

2000-01-18T23:59:59.000Z

271

Japan Retools Drug Research  

Science Journals Connector (OSTI)

Japan Retools Drug Research ... Like Takeda’s stock price, Japan’s drug R&D engine—flagging in recent years—appears to be recovering. ...

JEAN-FRANÇOIS TREMBLAY

2013-08-05T23:59:59.000Z

272

Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hydrogen Hydrogen Delivery Strategic Directions for Hydrogen Delivery Workshop May 7-8, 2003 Crystal City, Virginia Main Themes/Caveats Will be challenging (if not impossible) to meet the 2010 cost target with today's technology Without significant growth in product demand, progress will likely be slow even with incremental technology Group a little light on technical expertise, but feel captured main ideas required Less "weeding" of ideas, but more divergent thinking Targets/Objectives 2003 Status: $1.11/kg May be a bit lower than actual costs Baseline needs to be revisited 2005 Target: $1.01/kg Technically (10% improvement) could be met, but unlikely demand drivers will be present to encourage meeting target Likely no plant will be built in 2005

273

Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of  

Broader source: Energy.gov (indexed) [DOE]

SPR Oil to Marathon Petroleum Company SPR Oil to Marathon Petroleum Company Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of SPR Oil to Marathon Petroleum Company September 8, 2008 - 3:20pm Addthis WASHINGTON, DC - Today, September 8, 2008, the U.S. Department of Energy will deliver 250,000 barrels of oil from the Strategic Petroleum Reserve to Marathon Petroleum Company's Midwest refineries along the Capline pipeline system. The oil was requested by Marathon because of disruptions in supply caused by Hurricane Gustav. Media contact(s): Healy Baumgardner, (202) 586-4940 Addthis Related Articles Statement from DOE's Chief Spokesperson Andrew Beck Regarding Strategic Petroleum Reserve Oil Deliveries Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of

274

Office of Electricity Delivery and Energy Reliability FY 2010 Budget |  

Broader source: Energy.gov (indexed) [DOE]

FY 2010 FY 2010 Budget Office of Electricity Delivery and Energy Reliability FY 2010 Budget The FY 2010 Office of Electricity Delivery and Energy Reliability (OE) budget request is $208.0 million, $71.0 million more than the FY 2009 Appropriation. This increase reflects increased investments in research and development, particularly in energy storage, smart grid technologies, and cyber security areas. OE will also establish one of the Department's multi-disciplinary Energy Innovation Hubs (Hubs) that specifically focuses on Grid Materials, Devices, and Systems. The FY 2010 budget proposes a budget structure change to better align with the Department's priorities to establish a clean, secure energy future. Office of Electricity Delivery and Energy Reliability FY 2010 Budget

275

Machine and Beam Delivery Updates  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

MAchine and Beam delivery Updates FY13 MAchine and Beam delivery Updates FY13 Summary of Beam Delivery: FACET Summary Feb_15_22.pdf FACET Summary Feb_15_22.pdf FACET Summary Feb_23_Mar_1.pdf FACET Summary Feb_23_Mar_1.pdf FACET Summary Mar_2_8.pdf FACET Summary Mar_2_8.pdf FACET Summary Mar_9_15.pdf FACET Summary Mar_9_15.pdf FACET Summary Mar_16_22.pdf FACET Summary Mar_16_22.pdf FACET Summary Mar_23_29.pdf FACET Summary Mar_23_29.pdf FACET Summary Mar_30_Apr_5.pdf FACET Summary Mar_30_Apr_5.pdf FACET Summary Apr_6_12.pdf FACET Summary Apr_6_12.pdf FACET Summary Apr_27_May_3.pdf FACET Summary Apr_27_May_3.pdf FACET Summary May_4_10.pdf FACET Summary May_4_10.pdf Emittance Stability in Sector 2_31513.pdf Emittance Stability in Sector 2_31513.pdf FACET beam operations readiness with R56.pdf FACET beam operations readiness with R56.pdf (6/19/2013)

276

Nitrogen oxide delivery systems for biological media  

E-Print Network [OSTI]

Elevated levels of nitric oxide (NO) in vivo are associated with a variety of cellular modifications thought to be mutagenic or carcinogenic. These processes are likely mediated by reactive nitrogen species (RNS) such as ...

Skinn, Brian Thomas

2012-01-01T23:59:59.000Z

277

Autothermal hydrogen storage and delivery systems  

DOE Patents [OSTI]

Processes are provided for the storage and release of hydrogen by means of dehydrogenation of hydrogen carrier compositions where at least part of the heat of dehydrogenation is provided by a hydrogen-reversible selective oxidation of the carrier. Autothermal generation of hydrogen is achieved wherein sufficient heat is provided to sustain the at least partial endothermic dehydrogenation of the carrier at reaction temperature. The at least partially dehydrogenated and at least partially selectively oxidized liquid carrier is regenerated in a catalytic hydrogenation process where apart from an incidental employment of process heat, gaseous hydrogen is the primary source of reversibly contained hydrogen and the necessary reaction energy.

Pez, Guido Peter (Allentown, PA); Cooper, Alan Charles (Macungie, PA); Scott, Aaron Raymond (Allentown, PA)

2011-08-23T23:59:59.000Z

278

Vulnerability Analysis of Energy Delivery Control Systems  

Energy Savers [EERE]

services and applications * Known vulnerabilities are mitigated through effective patch management and removal of unneeded applications and services. New vulnerabilities in...

279

Virtual doctor's office telemedicine delivery system  

E-Print Network [OSTI]

Approved a s and nte t by: Charles S. L a Chair of Committee) Hsin-I Wu (Member) Jon F. Hunter (Member) William J. Hy n (Head of Department) December 2002 Major Subject: Biomedical Engineering ABSTRACT Virtual Doctor's Office Telemedicine... the course of my education at Texas AItM University. He has been a source of constant encouragement and guidance during my stay at the university. I would also like to acknowledge the help extended by Dr. don F. Hunter in obtaining the test data...

Sainath, Paavana

2012-06-07T23:59:59.000Z

280

Twelve-Month Evaluation of UPS Diesel Hybrid Electric Delivery Vans  

SciTech Connect (OSTI)

Results of an NREL study of a parallel hybrid electric-diesel propulsion system in United Parcel Service-operated delivery vans show that the hybrids had higher fuel economy than standard diesel vans.

Lammert, M.

2009-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Analysis of oil-pipeline distribution of multiple products subject to delivery time-windows  

E-Print Network [OSTI]

This dissertation defines the operational problems of, and develops solution methodologies for, a distribution of multiple products into oil pipeline subject to delivery time-windows constraints. A multiple-product oil pipeline is a pipeline system...

Jittamai, Phongchai

2006-04-12T23:59:59.000Z

282

Bacteria-mediated in vivo delivery of quantum dots into solid tumor  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer New approach using the probiotic Bifidobacterium bifidum as a vehicle to deliver QDs into the deep tissue of solid tumors in vivo was achieved. Black-Right-Pointing-Pointer Bifidobacterium bifidum delivery system has intrinsic biocompatibility. Black-Right-Pointing-Pointer The targeting efficacy was improved by folic acids. -- Abstract: Semiconductor nanocrystals, so-called quantum dots (QDs), promise potential application in bioimaging and diagnosis in vitro and in vivo owing to their high-quality photoluminescence and excellent photostability as well as size-tunable spectra. Here, we describe a biocompatible, comparatively safe bacteria-based system that can deliver QDs specifically into solid tumor of living animals. In our strategy, anaerobic bacterium Bifidobacterium bifidum (B. bifidum) that colonizes selectively in hypoxic regions of animal body was successfully used as a vehicle to load with QDs and transported into the deep tissue of solid tumors. The internalization of lipid-encapsuled QDs into B. bifidum was conveniently carried by electroporation. To improve the efficacy and specificity of tumor targeting, the QDs-carrying bacterium surface was further conjugated with folic acids (FAs) that can bind to the folic acid receptor overexpressed tumor cells. This new approach opens a pathway for delivering different types of functional cargos such as nanoparticles and drugs into solid tumor of live animals for imaging, diagnosis and therapy.

Liu, Ying [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China)] [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China); Zhou, Mei [Dept. of Radiation Medicine, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China)] [Dept. of Radiation Medicine, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China); Luo, Dan; Wang, Lijun; Hong, Yuankai [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China)] [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China); Yang, Yepeng, E-mail: yangyepeng@bjmu.edu.cn [Dept. of Radiation Medicine, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China)] [Dept. of Radiation Medicine, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China); Sha, Yinlin, E-mail: shyl@hsc.pku.edu.cn [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China) [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China); Biomed-X Center, Peking University, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China)

2012-09-07T23:59:59.000Z

283

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Broader source: Energy.gov (indexed) [DOE]

February 24, 2011 February 24, 2011 CX-005326: Categorical Exclusion Determination Boeing Distribution Management System (BDMS) CX(s) Applied: A1, A9, A11, B1.2, B1.7 Date: 02/24/2011 Location(s): Hazelwood, Missouri Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory February 24, 2011 CX-005325: Categorical Exclusion Determination Boeing Distribution Management System (BDMS) CX(s) Applied: A1, A9, A11, B1.2, B1.7 Date: 02/24/2011 Location(s): Oak Brook Terrace, Illinois Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory February 24, 2011 CX-005324: Categorical Exclusion Determination Boeing Distribution Management System (BDMS) CX(s) Applied: A1, A9, A11, B1.2, B1.7 Date: 02/24/2011 Location(s): Fort Collins, Colorado

284

Evaluation of Retrofit Delivery Packages  

SciTech Connect (OSTI)

Residential energy retrofit activities are a critical component of efforts to increase energy efficiency in the U.S. building stock; however, retrofits account for a small percentage of aggregate energy savings at relatively high per unit costs. This report by Building America research team, Alliance for Residential Building Innovation (ARBI), describes barriers to widespread retrofits and evaluates opportunities to improve delivery of home retrofit measures by identifying economies of scale in marketing, energy assessments, and bulk purchasing through pilot programs in portions of Sonoma, Los Angeles, and San Joaquin Counties, CA. These targeted communities show potential and have revealed key strategies for program design, as outlined in the report.

Berman, M.; Smith, P.; Porse, E.

2013-07-01T23:59:59.000Z

285

Strategic Directions for Hydrogen Delivery Workshop  

Broader source: Energy.gov [DOE]

The U.S. Department of Energy sponsored a Hydrogen Delivery Workshop in Washington, DC, May 7-8, 2003. Attendees included researchers, government officials, and industry members.

286

Final Report- Hydrogen Delivery Infrastructure Options Analysis  

Broader source: Energy.gov [DOE]

This report provides in-depth analysis of various hydrogen delivery options to determine the most cost effective infrastructure and R&D efforts for the long term.

287

Potential Carriers and Approaches for Hydrogen Delivery  

Broader source: Energy.gov [DOE]

Presentation by Matthew Hooks of TIAX at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007

288

Part IV: Section F: Deliveries and Performance  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

or the period of the order or any extension thereof expires, the Contractor shall resume work. The Contracting Officer shall make an equitable adjustment in the delivery...

289

MFRC Training Development & Delivery Program - Bloodstain & Toxicology...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Resource Center (MFRC) Training Development and Delivery Program increases access to forensic science training for publicly funded state and local forensic scientists. Its goals...

290

Drug Conjugates Lure Investment  

Science Journals Connector (OSTI)

Drug Conjugates Lure Investment ... Only two antibody-drug conjugates are on the market— Roche’s Kadcyla for breast cancer and Seattle Genetics’s Adcetris for lymphoma—but developers are stepping up investment in this new drug class. ... The new plant is part of a larger investment by the company in biologics manufacturing (see page 17). ...

ANN THAYER

2013-10-21T23:59:59.000Z

291

TIGER -- A technology to improve the delivery capability of nuclear bombs and the survivability of the delivery aircraft  

SciTech Connect (OSTI)

The TIGER (Terminal guided and Extended-Range) Program was initiated in 1972 to study improved delivery capabilities for stockpiled tactical nuclear bombs. The Southeast Asia conflict fostered the development of air-delivered standoff conventional weapons utilizing terminal guidance systems. SNL initiated the TIGER program to determine if current nuclear bombs could be provided with a similarly accurate standoff capabilities. These conventional weapon delivery techniques, while allowing highly accurate attack, generally require entering the target area at high altitude to establish line of sight to the target. In parallel with the TIGER program, system studies analyzed this concept and showed marked improvement in aircraft and weapon survivability with moderate standoff (10--20 km) if low level deliveries (60 m) could be accomplished. As a result of this work, the TIGER program was redirected in early 1974 to demonstrate a standoff bomb with good accuracy (90 m CEP) when delivered from low flying aircraft. This program redirection resulted in the selection of an inertial guidance system to replace the earlier terminal guidance systems. This program was called the Extended-Range Bomb (ERB). In May 1974, a joint Air Force/DOE study identified the desirability of having a single tactical weapon which could be employed against either fixed, preselected targets, or mobile battlefield targets. Studies conducted on the ERB system showed that the inertially guided weapon could fly not only the standoff mission but also a return-to-target mission against the mobile battlefield targets whose locations are not known accurately enough to use a standoff delivery. The ERB program evolved from these initial investigations into an exploratory program to develop the hardware and demonstrate the technology required to fly standoff and return-to-target trajectories. The application of this technology in the form of field retrofit kits to the B61 bomb is called TIGER II.

NONE

1980-12-31T23:59:59.000Z

292

LIFE Economics and Delivery Pathway Presentation to  

E-Print Network [OSTI]

risk to acceptable levels · Quantified in terms of confidence level that an issue has been demonstrated;Delivery plan reduces risk to commercially acceptable levels ·Fusion delivery abstracted to 38 core is necessary (but not sufficient) for economic viability Minimumforeconomics Cost and risk to buy additional

293

Delivery of Hydrogen Produced from Natural Gas  

E-Print Network [OSTI]

for transportation and stationary power. DOE Milestone #12;Hydrogen Delivery Options · Gaseous hydrogen - Pipelines · Materials Development - Repair, smart pipe, liners · Operational Technologies - Compressors, modeling, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas

294

NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM  

E-Print Network [OSTI]

Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

Hart, Steven N.

2011-02-22T23:59:59.000Z

295

Potential Carriers and Approaches for Hydrogen Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Carriers and Potential Carriers and Carriers and Potential Carriers and Approaches for Hydrogen Approaches for Hydrogen Delivery Delivery TIAX LLC 1601 S. D Anza Blvd. Cupertino CA, 95014 Tel. 408-517-1550 Reference: D0348 © 2007 TIAX LLC Hydrogen Delivery Analysis Meeting May 8-9, 2007 Columbia, Maryland Matthew Hooks Stefan Unnasch Stephen Lasher 1 Novel Hydrogen Carriers Project Overview Cost Density (wt. and vol.) Energy requirements Forecourt storage requirements Codes and standards H H 2 2 Plant, Liquefier, LH Plant, Liquefier, LH 2 2 storage storage H H 2 2 Tube Trailer Tube Trailer LH 2 2 Tank/ Fueling Station LH Tank/ Fueling Station The efficient delivery of hydrogen is necessary for the adoption of hydrogen as a transportation fuel, but numerous challenges must be met. 2 "Conventional" delivery options are limited by volumetric density,

296

Tissue-Specific Gene Delivery via Nanoparticle Coating  

E-Print Network [OSTI]

The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant ...

Harris, Todd J.

297

Suborbital freight delivery concept exploration  

SciTech Connect (OSTI)

Suborbital Freight, sometimes called Fast Freight, is delivery of high priority packages over intercontinental distances in periods of approximately one hour. The vehicles required are usually rocket-powered and have total ideal velocities of around 7.5 km/second. Analysis of this market indicates that there are niches where commercial operations are possible and might even be profitable using today{close_quote}s state-of-the-art technologies. The key requirements to capture this market are low nonrecurring costs, quick turnaround ({lt}9hours), and high reliability (0.999). This draft is a report on work in progress. The Fast Freight study will be completed before the STAIF-97 conference and results will be presented at that time. {copyright} {ital 1997 American Institute of Physics.}

Andrews, D.; Paris, S.; Rubeck, M. [Boeing Defense Space Group Seattle, Washington98124 (United States)

1997-01-01T23:59:59.000Z

298

A Fast Delivery Protocol for Total Order Broadcasting  

SciTech Connect (OSTI)

The conclusions of this report are: (1) Fast delivery protocol reduces the latency of message ordering for idle systems and keep comparable performances with communication history algorithms for busy systems; (2) The protocol optimizes the total ordering process by waiting for messages only from a subset of the machines in the group; and (3) The fast acknowledgment aggressively acknowledges total order messages to reduce the latency for idle system, and it is smart enough to hold the acknowledgments when the network communication is heavy.

Ou, Li [Tennessee Technological University; He, X. [Tennessee Technological University; Engelmann, Christian [ORNL; Scott, Stephen L [ORNL

2007-01-01T23:59:59.000Z

299

STATEMENT OF PATRICIA HOFFMAN ASSISTANT SECRETARY FOR ELECTRICITY DELIVERY AND ENERGY RELIABILITY  

Broader source: Energy.gov (indexed) [DOE]

APPROPRIATIONS SUBCOMMITTEE ON APPROPRIATIONS SUBCOMMITTEE ON ENERGY AND WATER DEVELOPMENT MARCH 27, 2012 Mr. Chairman and Members of the Committee, thank you for the opportunity to appear before you today to discuss the President's Fiscal Year (FY) 2013 budget for the Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE). It is the mission of this office to lead national efforts to modernize the electricity delivery system, enhance the security and reliability of America's energy infrastructure and

300

Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delivery and Delivery and Fueling (Text Alternative Version) to someone by E-mail Share Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Facebook Tweet about Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Twitter Bookmark Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Google Bookmark Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Delicious Rank Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Digg Find More places to share Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on AddThis.com... Publications Program Publications

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Special Delivery for Sustainability: Clean Cities Supports UPS...  

Broader source: Energy.gov (indexed) [DOE]

Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding Natural Gas Operations Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding...

302

Energy-Efficient Melting and Direct Delivery of High Quality...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum itmdelivery.pdf More...

303

Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery...  

Broader source: Energy.gov (indexed) [DOE]

Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop Targets, barriers and...

304

H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and...

305

Hydrogen Delivery R&D Activities | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

R&D Activities Hydrogen Delivery R&D Activities Hydrogen delivery technology may encompass several options over the short and long terms. The transportation and distribution...

306

Hydrogen Distribution and Delivery Fact Sheet | Department of...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Hydrogen Distribution and Delivery Fact Sheet Hydrogen Distribution and Delivery Fact Sheet Fact sheet produced by the Fuel Cell Technologies Office describing hydrogen...

307

Hydrogen Delivery Options and Issues | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Delivery Options and Issues Hydrogen Delivery Options and Issues Presentation by DOE's Mark Paster at the 2010 - 2025 Scenario Analysis for Hydrogen Fuel Cell Vehicles and...

308

Office of Electricity Delivery and Energy Reliability Recovery...  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery and Energy Reliability Recovery Program Plan Office of Electricity Delivery and Energy Reliability Recovery Program Plan Microsoft Word - OE PSRP June 5 2009...

309

Secretary of Energy Announces New Office of Electricity Delivery...  

Office of Environmental Management (EM)

New Office of Electricity Delivery & Energy Reliability Secretary of Energy Announces New Office of Electricity Delivery & Energy Reliability June 9, 2005 - 1:45pm Addthis...

310

Office of Electricity Delivery And Energy Reliability To Hold...  

Broader source: Energy.gov (indexed) [DOE]

Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy...

311

The Office of Electricity Delivery and Energy Reliability is...  

Broader source: Energy.gov (indexed) [DOE]

The Office of Electricity Delivery and Energy Reliability is Closely Monitoring Hurricane Irene (2011) The Office of Electricity Delivery and Energy Reliability is Closely...

312

Office of Electricity Delivery & Energy Reliability FY 2012 Budget...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation...

313

Office of Electricity Delivery and Energy Reliability Cyber Security...  

Broader source: Energy.gov (indexed) [DOE]

Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections On...

314

High power fiber delivery for laser ignition applications  

Science Journals Connector (OSTI)

The present contribution provides a concise review of high power fiber delivery research for laser ignition applications. The fiber delivery requirements are discussed in terms of exit...

Yalin, Azer P

2013-01-01T23:59:59.000Z

315

Measurement of photodynamic therapy drug concentrations in a tissue  

SciTech Connect (OSTI)

This is the final report of a one-year laboratory-directed research and development project at the Los Alamos National Laboratory (LANL). Photodynamic therapy (PDT) is an experimental treatment modality for cancer in which a photoactive molecule with an affinity for tumors in administered to the patient, then excited by light. Photoactivation creates singlet oxygen consequently killing the tissue. Knowledge of the concentration of the photoactive compound in the tissue is necessary for proper light dosimetry during PDT. Presently, the control of light application is problematic. If too much light is applied, damage to the surrounding tissue will occur. If insufficient light is applied, the targeted tissue volume will remain viable. The ideal implementation of PDT would use a feedback system for light delivery that incorporates the optical properties of the tissue and knowledge of the concentration of the photoactive compound. This project sought to develop a method for measuring photosensitizer concentrations in tissue phantoms that will lead to a noninvasive, endoscopically compatible, in vivo method of measuring PST drug concentrations.

Mourant, J.; Biglo, I.; Johnson, T.

1996-09-01T23:59:59.000Z

316

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments  

Science Journals Connector (OSTI)

...hydrogels prepared by a blend of chitosan, phopholipid and lauric aldehyde...163]. A number of MMP inhibitor-containing systems have...BMP-7 delivery system into chitosan-based scaffolds for bone...Biocompatibility of injectable chitosan-phospholipid implant systems...

2011-01-01T23:59:59.000Z

317

Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of  

Broader source: Energy.gov (indexed) [DOE]

Strategic Petroleum Reserve Oil Strategic Petroleum Reserve Oil Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of Strategic Petroleum Reserve Oil September 14, 2008 - 3:43pm Addthis WASHINGTON - The U.S. Department of Energy has agreed to deliver 200,000 barrels of emergency exchange oil from the Strategic Petroleum Reserve to ConocoPhillips Company's Wood River refinery along the Capline pipeline system. The Department will also deliver an additional 109,000 barrels of emergency exchange oil from the Strategic Petroleum Reserve to Placid Oil's Port Allen refinery along a Shell pipeline in Louisiana. The oil was requested by ConocoPhillips and Placid Oil because of disruptions in supply caused by Hurricanes Gustav and Ike. The deliveries will begin today. Media contact(s):

318

Fuel Cell Technologies Program Multi-Year Research, Development and Demonstration Plan - Section 3.2 Hydrogen Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Technical Plan - Delivery Technical Plan - Delivery Multi-Year Research, Development and Demonstration Plan Page 3.2 - 1 3.2 Hydrogen Delivery Delivery is an essential component of any future hydrogen infrastructure. It encompasses those processes needed to transport hydrogen from a central or semi-central production facility to the final point of use and those required to load the energy carrier directly onto a given fuel cell system. Successful commercialization of hydrogen-fueled fuel cell systems, including those used in vehicles, back-up power sources, and distributed power generators, will likely depend on a hydrogen delivery infrastructure that provides the same level of safety, convenience, and functionality as existing liquid and gaseous fossil

319

Delivery and Receipt | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Delivery and Receipt Delivery and Receipt Delivery and Receipt Delivery and Receipt of Personal Property Acquired by Purchase Card at Headquarters Receiving Items Purchased with the Purchase Card that are Shipped or Delivered by the Vendor All personal property acquired by using the purchase card should generally be delivered to and processed by the receiving office (loading dock). This will ensure inventory control identification, as appropriate and recording in the personal property management records. The following practices and procedures, as set forth by the Personal Property and Supply Management Team, Office of Logistics and Facility Operations, Office of Administration, are effective November 2007. These procedures were implemented to create a safe work environment, reduce

320

Incorporating traffic patterns to improve delivery performance  

E-Print Network [OSTI]

Traffic, construction and other road hazards impact the on-time performance of companies that operate delivery fleets. This study examines how incorporating traffic patterns in vehicle route development compares with ...

Dickinson, Melody J

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Coordinated part delivery using distributed planning  

E-Print Network [OSTI]

In this thesis, we develop a distributed mobile robot platform to deliver parts around a model construction site. The platform's robots, specialized into delivery robots and assembly robots, use a distributed coverage ...

Bolger, Adrienne (Adrienne M.)

2010-01-01T23:59:59.000Z

322

Status and EAC Recommendations for Electricity Delivery Workforce (September 2014)  

Broader source: Energy.gov [DOE]

Status and recommendations presented at the September 2014 meeting for Electricity Delivery Workforce (September 2014)

323

Optical measurement of drug concentrations in tissue  

SciTech Connect (OSTI)

This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The aim of this project was to develop noninvasive fiber-optic methods for measuring drug concentrations in tissue. Such a system would make possible the study of chemotherapy drug kinetics at specific, targeted locations in the body after the drug is administered. The major result of this project is the development of techniques for measuring changes in absorption of a medium with unknown scattering properties. The developed method was verified by testing on several media with scattering properties in the range typically found for tissue.

Mourant, J.R.; Bigio, I.J.; Jack, D.A.; Johnson, T.M.; Miller, H.D. [Los Alamos National Lab., NM (United States). Chemical Sciences and Technology Div.

1997-10-01T23:59:59.000Z

324

Illicit drugs in the environment  

Science Journals Connector (OSTI)

...Nick Voulvoulis Illicit drugs in the environment Ettore Zuccato Sara Castiglioni...but risks for human health and the environment cannot be excluded. Morphine, cocaine...time. illicit drugs|drugs of abuse|environment|sewage treatment plant|wastewater...

2009-01-01T23:59:59.000Z

325

Purchase, Delivery, and Storage of Gases  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Purchase, Delivery, and Storage of Gases Print Purchase, Delivery, and Storage of Gases Print ALS users should follow Berkeley Lab policy, as described below, for the purchase, delivery, storage, and use of all gases at the ALS. See Shipping and Receiving for information on any non-gas deliveries. Contacts: Gas purchase or delivery: ALS Receiving, 510-486-4494 Gas use and storage: Experiment Coordination, 510-486-7222, This e-mail address is being protected from spambots. You need JavaScript enabled to view it Gas Storage: Berkeley Lab Chemical Inventory All gas bottles and cylinders at the ALS must be identified with bar code and logged into the Berkeley Lab Chemical Inventory by ALS staff. The inventory will be updated periodically; for more information contact Experiment Coordination. Gases are stored either in the racks between buildings 6 and 7; toxic and corrosive gases are stored in Building 6, room 6C across the walkway from beamline 10.0.

326

Neutron crystallography aids drug design  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Neutron crystallography aids drug design Neutron crystallography aids drug design Researchers have used neutron crystallography for the first time to determine the structure of a...

327

Abstract 4396: Combination of intratumoral regulated IL-12 gene delivery and systemic chemotherapy with Palifosfamide (IPM-Tris) enhances anti-tumor effects in breast cancer (4T1) model  

Science Journals Connector (OSTI)

...of tumors to escape detection and/or destruction by the immune system. This study explored...Rheoswitch Therapeutic System, (RTS), a novel inducible promoter system was used. Expression...30) compared to vehicle. In contrast, a single...

Selva Murugesan; William Fogler; David Valacer; Hagop Youssoufian; Robert A. Morgan; Ronald Herberman; Shelia Connelly; Susan E. Hart; Mini Bharathan; Timothy Chan; Diaa Shakleya; Mario Moreno; and John A. Barrett

2012-06-04T23:59:59.000Z

328

Career Opportunities in Biotechnology and Drug Developmentand Drug Development  

E-Print Network [OSTI]

Career Opportunities in Biotechnology and Drug Developmentand Drug Development Career Opportunities.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 1 #12-inflammatories www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development

Puglisi, Joseph

329

2012 Revenue for Delivery Service Providers  

U.S. Energy Information Administration (EIA) Indexed Site

Revenue for Delivery Service Providers" Revenue for Delivery Service Providers" "(Data from form EIA-861 schedule 4C)" ,,,"Revenue (Thousands Dollars)" "Entity","State","Ownership","Residential","Commercial","Industrial","Transportation","Total" "Pacific Gas & Electric Co","CA","Investor Owned",38657,306699,232366,2843,580565 "San Diego Gas & Electric Co","CA","Investor Owned",1019.1,62400.1,84143.3,0,147562.5 "Southern California Edison Co","CA","Investor Owned",6706,456007,69193,".",531906 "Connecticut Light & Power Co","CT","Investor Owned",362262,514043,100262,6681,983248

330

NREL: Innovation Impact - Energy Systems Integration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and their customers while giving utilities more control over their electric delivery systems. NREL's research in energy systems integration will prepare more technologies for the...

331

Tracking Mobile Units for Dependable Message Delivery  

E-Print Network [OSTI]

Tracking Mobile Units for Dependable Message Delivery Amy L. Murphy, Member, IEEE Computer Society at their disposal at any time, mobile computing is developing as an important research area. One of the fundamental problems in mobility is maintaining connectivity through message passing as the user moves through

Zhou, Yuanyuan

332

Modeling Delivery Delay for Flooding in Mobile  

E-Print Network [OSTI]

Modeling Delivery Delay for Flooding in Mobile Ad Hoc Networks TR-UTEDGE-2009-004 Taesoo Jun for Flooding in Mobile Ad Hoc Networks Taesoo Jun, Nirmalya Roy, and Christine Julien The Center for Excellence. In mobile networks, a major component of many of these routing protocols is some form of flooding, which

Julien, Christine

333

Improvements to Hydrogen Delivery Scenario Analysis  

E-Print Network [OSTI]

­ Improved liquefier, pipeline, compressors, storage, labor, indirect capital, and O&M cost estimatesImprovements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results May 8, 2007 Amgad and storage are at or adjacent to Liquid Hydrogen (LH) TruckH2 Production 100 or 1500 kg/d Compressed H2 (CH

334

Colorado Natural Gas % of Total Residential Deliveries (Percent...  

Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

% of Total Residential Deliveries (Percent) Colorado Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

335

DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project...  

Broader source: Energy.gov (indexed) [DOE]

Delivery High-Pressure Tanks and Analysis Project Review Meeting DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting On February 8-9, 2005, the Department...

336

California Natural Gas Interstate Deliveries to All States (Million...  

U.S. Energy Information Administration (EIA) Indexed Site

Deliveries to All States (Million Cubic Feet) California Natural Gas Interstate Deliveries to All States (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5...

337

California Natural Gas % of Total Electric Utility Deliveries...  

U.S. Energy Information Administration (EIA) Indexed Site

Electric Utility Deliveries (Percent) California Natural Gas % of Total Electric Utility Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

338

Connecticut Natural Gas % of Total Residential Deliveries (Percent...  

U.S. Energy Information Administration (EIA) Indexed Site

% of Total Residential Deliveries (Percent) Connecticut Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7...

339

DOE and Industry Showcase New Control Systems Security Technologies...  

Broader source: Energy.gov (indexed) [DOE]

Technology Development Energy Delivery Systems Cybersecurity Control Systems Security News Archive DOE and Industry Showcase New Control Systems Security Technologies at...

340

2012 Annual Planning Summary for Electricity Delivery and Energy Reliability  

Broader source: Energy.gov [DOE]

The ongoing and projected Environmental Assessments and Environmental Impact Statements for 2012 and 2013 within Electricity Delivery and Energy Reliability.

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Energy Trade-offs among Content Delivery Architectures  

E-Print Network [OSTI]

Energy Trade-offs among Content Delivery Architectures Anja Feldmann Andreas Gladisch Mario Kind to incorporate var- ious home devices such as set-top boxes into content delivery architectures using the Peer-to-Peer (P2P) paradigm. The hope is to enhance the efficiency of content delivery, e.g., in terms

Smaragdakis, Georgios

342

Shattuck Lecture: Chronic Infectious Disease and the Future of Health Care Delivery  

Science Journals Connector (OSTI)

...does or does not happen and how to improve it may now represent medicine's most important task. In settings of poverty, the delivery gap can be a gulf, especially in the case of chronic illness. In the rural villages and small towns in Rwanda, Malawi, and Lesotho, where the nongovernmental organization... Work that has been done in low-income countries to build health systems that can respond to AIDS and TB (as well as other acute and chronic diseases) shows that with adequate resources, we can improve care delivery, sharply reducing morbidity and mortality.

Farmer P.E.

2013-12-19T23:59:59.000Z

343

Analysis of 9-tetrahydrocannabinol Driving Under the Influence of Drugs Cases in Colorado from January 2011 to February 2014  

Science Journals Connector (OSTI)

......profile (3, 4). Smoking is the most common route of marijuana administration as it provides rapid delivery of THC to the brain, quickly producing the desired effects of the drug. Peak effects of smoking are generally noted 20-30 min after use, with......

Sarah Urfer; Jaime Morton; Vanessa Beall; Jeanna Feldmann; Justin Gunesch

2014-10-01T23:59:59.000Z

344

Marketing of New Drugs  

Science Journals Connector (OSTI)

Marketing of New Drugs ... But there was no doubt an excess of expenditure for promotional purposes in recent years and the industry is gradually reducing this because the sales department cannot ask for the marketing of as many new products has it did in the past. ...

PAUL DE HAEN

1964-10-12T23:59:59.000Z

345

Vectren Energy Delivery of Ohio (Gas) - Residential Energy Efficiency  

Broader source: Energy.gov (indexed) [DOE]

Vectren Energy Delivery of Ohio (Gas) - Residential Energy Vectren Energy Delivery of Ohio (Gas) - Residential Energy Efficiency Rebates Vectren Energy Delivery of Ohio (Gas) - Residential Energy Efficiency Rebates < Back Eligibility Construction Installer/Contractor Residential Savings Category Heating & Cooling Commercial Heating & Cooling Heating Home Weatherization Commercial Weatherization Sealing Your Home Ventilation Appliances & Electronics Water Heating Program Info State Ohio Program Type Utility Rebate Program Rebate Amount Furnace: $150 - $275 Boiler: $300 Storage Water Heater: $125 Tankless Water Heater: $150 Programmable Thermostat: $20 Attic Insulation: Up to $600 Wall Insulation: Up to $700 Air Sealing: Up to $250 Provider Vectren Energy Delivery of Ohio Vectren Energy Delivery offers residential natural gas customers in Ohio

346

The impact of China’s national essential medicine system on improving rational drug use in primary health care facilities: an empirical study in four provinces  

Science Journals Connector (OSTI)

The National Essential Medicine System (NEMS) is a new policy in China launched in 2009 to improve the appropriate use of medications. This study aims to examine the outcomes of the NEMS objectives in terms of...

Yan Song; Ying Bian; Max Petzold; Lingui Li; Aitian Yin

2014-10-01T23:59:59.000Z

347

Hydrogen production and delivery analysis in US markets : cost, energy and greenhouse gas emissions.  

SciTech Connect (OSTI)

Hydrogen production cost conclusions are: (1) Steam Methane Reforming (SMR) is the least-cost production option at current natural gas prices and for initial hydrogen vehicle penetration rates, at high production rates, SMR may not be the least-cost option; (2) Unlike coal and nuclear technologies, the cost of natural gas feedstock is the largest contributor to SMR production cost; (3) Coal- and nuclear-based hydrogen production have significant penalties at small production rates (and benefits at large rates); (4) Nuclear production of hydrogen is likely to have large economies of scale, but because fixed O&M costs are uncertain, the magnitude of these effects may be understated; and (5) Given H2A default assumptions for fuel prices, process efficiencies and labor costs, nuclear-based hydrogen is likely to be more expensive to produce than coal-based hydrogen. Carbon taxes and caps can narrow the gap. Hydrogen delivery cost conclusions are: (1) For smaller urban markets, compressed gas delivery appears most economic, although cost inputs for high-pressure gas trucks are uncertain; (2) For larger urban markets, pipeline delivery is least costly; (3) Distance from hydrogen production plant to city gate may change relative costs (all results shown assume 100 km); (4) Pipeline costs may be reduced with system 'rationalization', primarily reductions in service pipeline mileage; and (5) Liquefier and pipeline capital costs are a hurdle, particularly at small market sizes. Some energy and greenhouse gas Observations: (1) Energy use (per kg of H2) declines slightly with increasing production or delivery rate for most components (unless energy efficiency varies appreciably with scale, e.g., liquefaction); (2) Energy use is a strong function of production technology and delivery mode; (3) GHG emissions reflect the energy efficiency and carbon content of each component in a production-delivery pathway; (4) Coal and natural gas production pathways have high energy consumption and significant GHG emissions (in the absence of carbon caps, taxes or sequestration); (5) Nuclear pathway is most favorable from energy use and GHG emissions perspective; (6) GH2 Truck and Pipeline delivery have much lower energy use and GHG emissions than LH2 Truck delivery; and (7) For LH2 Truck delivery, the liquefier accounts for most of the energy and GHG emissions.

Mintz, M.; Gillette, J.; Elgowainy, A. (Decision and Information Sciences); ( ES)

2009-01-01T23:59:59.000Z

348

Final Report - Hydrogen Delivery Infrastructure Options Analysis  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

The Power of Experience The Power of Experience Final Report Hydrogen Delivery Infrastructure Options Analysis DOE Award Number: DE-FG36-05GO15032 Project director/principal investigator: Tan-Ping Chen Consortium/teaming Partners: Air Liquide, Chevron Technology Venture, Gas Technology Institute, NREL, Tiax, ANL Hydrogen Delivery Infrastructure Options Analysis ii TABLE OF CONTENTS SECTION 1 EXECUTIVE SUMMARY ........................................................................... 1-1 1.1 HOW THE RESEARCH ADDS TO THE UNDERSTANDING OF THE AREA INVESTIGATED. 1-1 1.2 TECHNICAL EFFECTIVENESS AND ECONOMIC FEASIBILITY OF THE METHODS OR TECHNIQUES INVESTIGATED OR DEMONSTRATED .................................................... 1-1 1.3 HOW THE PROJECT IS OF BENEFIT TO THE PUBLIC..................................................... 1-1

349

DOE to Defer Strategic Petroleum Reserve RIK Deliveries | Department of  

Broader source: Energy.gov (indexed) [DOE]

to Defer Strategic Petroleum Reserve RIK Deliveries to Defer Strategic Petroleum Reserve RIK Deliveries DOE to Defer Strategic Petroleum Reserve RIK Deliveries June 5, 2008 - 12:51pm Addthis 2.1 Million Barrels Delayed Until Spring 2009 WASHINGTON, DC - The U. S. Department of Energy today announced it will defer approximately 2.1 million barrels of royalty-in-kind (RIK) exchange crude oil that had been scheduled for delivery to the nation's Strategic Petroleum Reserve sites (SPR) this summer. The deferred deliveries are part of a royalty-in-kind crude oil exchange that began in January 2008 and were to total approximately 11 million barrels delivered to the SPR through July 2008. The approximately 2.1 million barrels will be deferred for delivery until March-May 2009, after the winter heating season. Deliveries of approximately 2.8 million

350

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network [OSTI]

D. F. , Kahl, S. B. , Bjornstad, K. A. , Bauer, W. F. ,L. , Blakely, E. A. , Bjornstad, K. A. , Deen, D. F. ,Blakely 2 , Kathleen A. Bjornstad 2 , Xiao Shu 3 ,Thomas F.

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

351

Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA  

SciTech Connect (OSTI)

Apoferritin is a nanostructured material with a uniform size and spherical structure, and it has excellent bio-compatibility. In this work, we report the use of apoferritin as a novel and biocompatible carrier for stabilizing enzymes and their activities. We used glucose oxidase (GOx) as a model enzyme. GOx was immobilized on the surface of the apoferritin through a green synthetic approach taking advantage of bioaffinity binding between streptavidin and biotin. As a result, a glucose oxidase-biotin/streptavidin/biotin-apoferritin conjugate (Apo-GOx) was prepared using streptavidin as a bridge. The synthesized Apo-GOx was characterized with transmission electron microscopy, ultraviolet, and fluorescence spectroscopy. The activity and stability of GOx on the surface of the apoferritin were studied in different environments, such as temperature, chemicals, and pH, in comparison with the biotinylated GOx (B-GOx). The results showed that the activity of GOx on the apoferritin surface was significantly enhanced. The thermal and chemical stability of the GOx on the apoferritin was also greatly improved compared to free B-GOx in a solution. It was found that the activity of the GOx on the apoferritin only lost 30% in comparison to a 70% loss of free B-GOx after a 2-hr incubation at 50oC. There was almost no decrease in activity for the GOx on the apoferritin as compared to an 80% activity decrease for free B-GOx after 30 minutes of incubation in a 5 M urea solution. The GOx immobilized apoferritin nanoparticles exhibited high sensitivity for glucose detection with a detection limit of 3 nM glucose. This work offers a novel approach for immobilizing enzymes with enhanced stability and activity, and this method may find a number of applications, such as in catalysis and bioassys/biosensors.

Ma Ham, Aihui; Wu, Hong J.; Wang, Jun; Kang, Xinhuang; Zhang, Youyu; Lin, Yuehe

2011-05-11T23:59:59.000Z

352

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery  

Science Journals Connector (OSTI)

Overwijk, W. W.; Theoret, M. R.; Finkelstein, S. E.; Surman, D. R.; de Jong, L. A.; Vyth-Dreese, F. A.; Dellemijn, T. A.; Antony, P. A.; Spiess, P. J.; Palmer, D. C. J. Exp. ... Overwijk, Willem W.; Theoret, Marc R.; Finkelstein, Steven E.; Surman, Deborah R.; de Jong, Laurina A.; Vyth-Dreese, Florry A.; Dellemijn, Trees A.; Antony, Paul A.; Spiess, Paul J.; Palmer, Douglas C.; Heimann, David M.; Klebanoff, Christopher A.; Yu, Zhiya; Hwang, Leroy N.; Feigenbaum, Lionel; Kruisbeek, Ada M.; Rosenberg, Steven A.; Restifo, Nicholas P. ...

Ronnie H. Fang; Che-Ming J. Hu; Brian T. Luk; Weiwei Gao; Jonathan A. Copp; Yiyin Tai; Derek E. O’Connor; Liangfang Zhang

2014-03-27T23:59:59.000Z

353

The evaluation of melamine dendrimers as potential macromolecular vehicles for anticancer drug delivery  

E-Print Network [OSTI]

.p. injections of 2.5-40 mg/kg of dendrimers were administered at 3 week intervals. Forty- eight hours following the last administration, blood chemistry worked revealed no renal * Reprinted from ?In vitro....p. injections of 2.5-40 mg/kg of dendrimers were administered at 3 week intervals. Forty- eight hours following the last administration, blood chemistry worked revealed no renal * Reprinted from ?In vitro...

Neerman, Michael Frederick

2005-08-29T23:59:59.000Z

354

Design, synthesis, and evaluation of dendrimers based on melamine as drug delivery vehicles  

E-Print Network [OSTI]

.1 Divergent and convergent synthetic routes to dendrimers .......................... 2 1.2 Architecture of dendrimers: (a) PPI; (b) PAMAM; (c) polyester; (d) triazine-based dendrimer... 3.9 Post-PET biodistribution data of a 124 I-labeled dendrimer (~17 kDa) in nude mice with PC-3-Luc xenografts at 48 h post-injection .................. 41 4.1 1 H NMR assignment and integration of 2 in the expanded region 4.8 to 8.2 ppm...

Lim, Jong Doo

2009-05-15T23:59:59.000Z

355

Fabrication of Metal/Oxide Nanostructures by Anodization Processes for Biosensor, Drug Delivery and Supercapacitor Applications  

E-Print Network [OSTI]

applications of micro/nano structures; (2) novel processes to innovate anodic aluminum oxide nanotube template; (3) the supercapacitor applications of anodic titanium oxide. First, the extremely high surface area AAO coated microneedle and microneedle array...

Chen, Po-Chun

2014-01-13T23:59:59.000Z

356

A novel method for the preparation of biodegradable microspheres for protein drug delivery  

Science Journals Connector (OSTI)

...glucose, i.e. linear amylase and branched amylopectin (Young 1984). Starch...release from poly(alpha-hydroxy acid) microspheres...properties of substituted amylase matrices. Int. J...Marchessault1998Cross-linked high amylose starch for controlled...

2006-01-01T23:59:59.000Z

357

Carbon nanostructures as multi-functional drug delivery Rafael G. Mendes,a  

E-Print Network [OSTI]

the various properties of carbon nanostructures that allow such multi-functionality. Recent advances then worked as a Research Fellow at the German Aerospace Center (DLR) at the Institute of Space Sensor Tech- structures, in particular carbon based nanomaterials, as well as advanced techniques

Cuniberti, Gianaurelio

358

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds  

Science Journals Connector (OSTI)

...hospitalized monitoring (Price et al. 1996; Somayaji...step usually includes heating, which, even if...technique (water/oil/water). PLGA...without external heating. The compaction procedure...0885328204043200 ) Price, J. S. , A. F...

2010-01-01T23:59:59.000Z

359

Abstract B40: Injectable multifunctional biodegradable polymeric microspheres for localized drug delivery in breast cancer treatment  

Science Journals Connector (OSTI)

...Abstracts: Sixth AACR Conference: The Science of Cancer Health Disparities; December...Uhrich 5 Wei Yue 5 1African University of Science and Technology, Abuja, Fct-Abuja...2Princeton University, Princeton, NJ, 3Sheda Science and Technology Complex (SHESTCO), Abuja...

John David Obayemi; Winston Oluwole Soboyejo; Olushola S. Odusanya; Nicolas Anuku; Kathryn E. Uhrich; Wei Yue

2014-11-01T23:59:59.000Z

360

pH-sensitive core-shell nanoparticles for intracellular drug delivery  

E-Print Network [OSTI]

Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis ...

Hu, Yuhua, Ph. D. Massachusetts Institute of Technology

2008-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites  

E-Print Network [OSTI]

Sailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructureMichael J. Engineering the chemistry and nanostructure of

Perelman, Loren Avery

2008-01-01T23:59:59.000Z

362

Chemically modified and nanostructured porous silicon as a drug delivery material and device  

E-Print Network [OSTI]

Sailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructure

Anglin, Emily Jessica

2007-01-01T23:59:59.000Z

363

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds  

Science Journals Connector (OSTI)

...need for hospitalized monitoring (Price et al. 1996; Somayaji et al. 1998...freeze-drying and desiccation at 37C. Poly(ethylene glycol) (PEG) was included in the...doi:10.1177/0885328204043200 ) Price, J. S. , A. F. Tencer, D. M...

2010-01-01T23:59:59.000Z

364

Refactored M13 Bacteriophage as a Platform for Tumor Cell Imaging and Drug Delivery  

E-Print Network [OSTI]

M13 bacteriophage is a well-characterized platform for peptide display. The utility of the M13 display platform is derived from the ability to encode phage protein fusions with display peptides at the genomic level. However, ...

Ghosh, Debadyuti

365

Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery  

Science Journals Connector (OSTI)

...promote the bone regeneration process. mesoporous bioceramics...accelerating the healing process. Thus, the design, development and commercialization of bioactive and biodegradable...elements play key roles in the processes that promote bone formation...

2012-01-01T23:59:59.000Z

366

MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells  

E-Print Network [OSTI]

imaging; theranostic nanomedicine; doxorubicin; Rv 6 integrin; superparamagnetic iron oxide; lung cancer

Gao, Jinming

367

Peptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review  

Science Journals Connector (OSTI)

...defined multivalent inhibitors of the adherence...Chemical modification of chitosan. 3. Hyperbranched chitosan-sialic acid dendrimer...of dendrimerized chitosan-sialic acid hybrid...multivalent ligands and inhibitors. Angew. Chem...

2012-01-01T23:59:59.000Z

368

NEST Scientific Report 2007-2009 Nanotechnology for intracellular delivery and targeting of drugs, nanoreporters  

E-Print Network [OSTI]

attention on the arginine-rich motif derived from the HIV transactivator of transcription protein Tat (residues 47-57 YGRKKRRQRRR of HIV-Tat protein full length). In order to elucidate the entrance pathway of Tat arginin-rich peptides and provides further information on the controversial mechanism of its

Abbondandolo, Alberto

369

Theoretical and experimental investigations of passive and ultrasound-enhanced transdermal drug delivery  

E-Print Network [OSTI]

In the initial investigation of this thesis, Fick's second law of diffusion was modified to describe both the transient, and the steady-state, transdermal transport of hydrophilic permeants through unbranched, aqueous pore ...

Kushner, Joseph, IV

2007-01-01T23:59:59.000Z

370

Water-soluble carbon nanotube compositions for drug delivery and medicinal applications  

DOE Patents [OSTI]

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

Tour, James M.; Lucente-Schultz, Rebecca; Leonard, Ashley; Kosynkin, Dmitry V.; Price, Brandi Katherine; Hudson, Jared L.; Conyers, Jr., Jodie L.; Moore, Valerie C.; Casscells, S. Ward; Myers, Jeffrey N.; Milas, Zvonimir L.; Mason, Kathy A.; Milas, Luka

2014-07-22T23:59:59.000Z

371

Applications of single molecule and nanoparticle imaging in chemical separation, photocatalysis, and drug delivery.  

E-Print Network [OSTI]

??This dissertation includes five chapters. Chapter 1 introduces single molecule and nanoparticle imaging techniques and their applications. Chapter 2 is a study of electrophoretic migration… (more)

Han, Rui

2014-01-01T23:59:59.000Z

372

Bioadhesive PAA-PEG-PAA triblock copolymer hydrogels for drug delivery in oral cavity  

Science Journals Connector (OSTI)

A series of poly(amidoamine)-poly(ethylene glycol)-poly(amidoamine) (PAA-PEG-PAA) triblock copolymers were designed and prepared to...1H NMR spectroscopy and gel permeation chromatography. The PAA-PEG-PAA copolym...

Minh Khanh Nguyen; Doo Sung Lee

2010-03-01T23:59:59.000Z

373

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network [OSTI]

Synthetic Nano-Low Density Lipoprotein as Targeted Drugmicroemulsion; peptide; nano-low density lipoproteintherapeutic agents. A synthetic nano-LDL (nLDL) particle was

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

374

Synthesis and Characterization of Lipid-Polymer Hybrid Nanoparticles for Combinatorial Drug Delivery  

E-Print Network [OSTI]

that has versatile functionality, good serum stability, circulates in the body long enough to reach the targeting tissues, and is biocompatible. A promising formulation platform that embodies these features is the lipid-polymer hybrid nanoparticles...

Stavropoulos, Kathy

2011-08-31T23:59:59.000Z

375

Novel Approaches to Breast Cancer Therapy: Evaluation of Next Generation Dendrimers for Drug Delivery  

E-Print Network [OSTI]

vi LIST OF FIGURES FIGURE Page 1 First generation dendrimer transfection- n/p 7.5. 30,000 cells / well were plated ...................................................................................................................... 8 2 Second... with either dried or liquid dendrimer. Treatment of wells with dried dendrimer was as follows: two dendrimers (F2-1 and G2- 5) of varying concentrations (n/p 5, n/p 7.5, n/p 10) were dried in a separate plate. OptiMEM and DNA were added to each well...

Snow, Merideth

2010-07-14T23:59:59.000Z

376

Candidate Radiation Drugs Inch Forward  

Science Journals Connector (OSTI)

Candidate Radiation Drugs Inch Forward 10.1126/science.331.6024...radiation, workers at the damaged Fukushima nuclear plant wear protective gear...Candidate radiation drugs inch forward. | News | 0 (E)-4-carboxystyryl-4-chlorobenzylsulfone...

Yudhijit Bhattacharjee

2011-03-25T23:59:59.000Z

377

Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes  

E-Print Network [OSTI]

Theranostics 2011, 1 http://www.thno.org 277 Theranostics 2011; 1:277-289 Research Paper Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes Prakash Manikwar1, Bimo A. Tejo1,2, Heather Shinogle3, David S... via a unique pathway Theranostics 2011, 1 http://www.thno.org 278 referred to as CAM-mediated endocytosis [10-13]. Ligands that bind to CAM can be used to selectively target drugs for intracellular delivery to immune cells expressing...

Manikwar, Prakash; Tejo, Bimo A.; Shinogle, Heather; Moore, David S.; Zimmerman, Tahl; Blanco, Francisco; Siahaan, Teruna J.

2010-05-10T23:59:59.000Z

378

A novel nanoscale delivery system for spatio-temporal delivery of combination chemotherapy  

E-Print Network [OSTI]

In the continuing search for effective treatments for cancer, the emerging model is the combination of traditional chemotherapy with anti-angiogenesis agents that inhibit blood vessel growth. However, the implementation ...

Eavarone, David A. (David Alan)

2009-01-01T23:59:59.000Z

379

Drug Testing for DOE Positions | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing Matrix Secretary Bodman's Memorandum Regarding Drug Testing at DOE Fact...

380

Role of Pluronic F127 micelles in enhancing ocular delivery of ciprofloxacin  

Science Journals Connector (OSTI)

Abstract In this study, Pluronic F127 micellar systems have been utilized to enhance ocular delivery of ciprofloxacin (CPX) antibiotic. Critical micelle concentration of the Pluronic F127 block copolymer had been determined in isotonic phosphate buffer at pH 7.4 and in simulated lacrimal fluid (SLF) at 25 and 34 °C. Micellar systems of Pluronic F127 have been accordingly used to improve CPX solubility in isotonic phosphate buffer solution at different pH. In vitro release rate of CPX from micellar systems was investigated in SLF. Ocular delivery of selected CPX micellar formulations has been investigated and compared with that of commercially available CPX eye drops (Ciprocin®) in rabbit's eye. Pharmacokinetic parameters such as Cmax, Tmax, elimination rate constant, t1/2, MRT and AUC0 ? ? were determined. The results of this study showed that, Pluronic F127 micellar systems have been shown to significantly improve CPX solubility in isotonic phosphate buffer solution at different pH. The viscosity of these systems was low indicating the formation of aqueous eye drops. Also, in vitro release rate of CPX was significantly higher from Pluronic F127 system prepared at pH 4.5 and 6 than that at pH 7. The investigated micellar formulations showed a significant improvement in ocular delivery of CPX compared with that of commercial CPX eye drops.

Ehab I. Taha; Mohamed M. Badran; Magda H. El-Anazi; Mohsen A. Bayomi; Ibrahim M. El-Bagory

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure  

Science Journals Connector (OSTI)

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure ... The human brain is a uniquely complex organ, which has evolved a sophisticated protection system to prevent injury from external insults and toxins. ... Designing molecules that can overcome this protection system and achieve optimal concentration at the desired therapeutic target in the brain is a specific and major challenge for medicinal chemists working in CNS drug discovery. ...

Zoran Rankovic

2014-12-11T23:59:59.000Z

382

H2A Delivery Scenario Model and Analyses  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

H2A Delivery Scenario Model H2A Delivery Scenario Model and Analyses Marianne Mintz and Jerry Gillette DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting February 8, 2005 2 Pioneering Science and Technology Office of Science U.S. Department of Energy Topics * Delivery Scenarios - Current status - Future scenarios * Delivery Scenarios model - Approach - Structure - Current status - Results * Pipeline modeling - Approach - Key assumptions - Results * Next Steps 3 Pioneering Science and Technology Office of Science U.S. Department of Energy Delivery Scenarios 4 Pioneering Science and Technology Office of Science U.S. Department of Energy Three-Quarters of the US Population Reside in Urbanized Areas East of the Mississippi there are many large, proximate urban areas. In the West

383

The Affordable Care Act, health care reform, prescription drug formularies and utilization management tools  

Science Journals Connector (OSTI)

Summary The U.S. Patient Protection and Affordable Care Act (hence, Affordable Care Act, or ACA) was signed into law on March 23, 2010. Goals of the ACA include decreasing the number of uninsured people, controlling cost and spending on health care, increasing the quality of care provided, and increasing insurance coverage benefits. This manuscript focuses on how the ACA affects pharmacy benefit managers and consumers when they have prescriptions dispensed. \\{PBMs\\} use formularies and utilization control tools to steer drug usage toward cost-effective and efficacious agents. A logic model was developed to explain the effects of the new legislation. The model draws from peer-reviewed and gray literature commentary about current and future U.S. healthcare reform. Outcomes were identified as desired and undesired effects, and expected unintended consequences. The ACA extends health insurance benefits to almost 32 million people and provides financial assistance to those up to 400% of the poverty level. Increased access to care leads to a similar increase in overall health care demand and usage. This short-term increase is projected to decrease downstream spending on disease treatment and stunt the continued growth of health care costs, but may unintentionally exacerbate the current primary care physician shortage. The ACA eliminates limitations on insurance and increases the scope of benefits. Online health care insurance exchanges give patients a central location with multiple insurance options. Problems with prescription drug affordability and control utilization tools used by \\{PBMs\\} were not addressed by the ACA. Improving communication within the U.S. healthcare system either by innovative health care delivery models or increased usage of health information technology will help alleviate problems of health care spending and affordability.

Brian L. Ung; C. Daniel Mullins

2014-01-01T23:59:59.000Z

384

Systems Analysis Workshop Purpose  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

National Renewable Energy Laboratory National Renewable Energy Laboratory DOE Hydrogen Program DOE Hydrogen Program Systems Analysis Workshop Systems Analysis Workshop Systems Integration Production Delivery Conversion Application Education Codes & Standards Safety Tech Validation Storage Systems Integration Production Delivery Conversion Application Education Codes & Standards Safety Tech Validation Storage Washington D.C. 28-29 Jul 04 Dale Gardner Systems Integration Operated for the U.S. Department of Energy by Midwest Research Institute * Battelle 2 Systems Analysis Workshop Topics * Meeting Goals * Systems Integration * Roles/Responsibilities of Analysis Participants * Systems Analysis * From this Workshop * Capability Presentations 3 Systems Analysis Workshop Meeting Goals 1) Understand the roles and activities of the DOE Technology Analyst,

385

Materials Solutions for Hydrogen Delivery in Pipelines  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Solutions for Solutions for Hydrogen Delivery in Pipelines Dr. Subodh K. Das Secat, Inc. September 26, 2007 This presentation does not contain any proprietary, confidential, or otherwise restricted information Project Team SECAT (KY) Project Manager Oregon Steel Mills (OR) Steel Pipe Producer Columbia Gas of Kentucky (KY) NG transporter Schott North America (PA) Glass coatings supplier Chemical Composite Coatings (GA) Composites coatings Advanced Technology Corp. (TN) ABI technology provider ASME (NY) Codes and Standards DGS Metallurgical Solutions (OR) Steel consulting University of Illinois (IL) Basic embrittlement studies Oak Ridge National Laboratory (TN) Applied research Objective and Deliverables Objective: ∑ Develop materials technologies to minimize embrittlement of

386

TIMELY DELIVERY OF LASER INERTIAL FUSION ENERGY (LIFE)  

SciTech Connect (OSTI)

The National Ignition Facility (NIF), the world's largest and most energetic laser system, is now operational at Lawrence Livermore National Laboratory. A key goal of the NIF is to demonstrate fusion ignition for the first time in the laboratory. Its flexibility allows multiple target designs (both indirect and direct drive) to be fielded, offering substantial scope for optimization of a robust target design. In this paper we discuss an approach to generating gigawatt levels of electrical power from a laser-driven source of fusion neutrons based on these demonstration experiments. This 'LIFE' concept enables rapid time-to-market for a commercial power plant, assuming success with ignition and a technology demonstration program that links directly to a facility design and construction project. The LIFE design makes use of recent advances in diode-pumped, solid-state laser technology. It adopts the paradigm of Line Replaceable Units utilized on the NIF to provide high levels of availability and maintainability and mitigate the need for advanced materials development. A demonstration LIFE plant based on these design principles is described, along with the areas of technology development required prior to plant construction. A goal-oriented, evidence-based approach has been proposed to allow LIFE power plant rollout on a time scale that meets policy imperatives and is consistent with utility planning horizons. The system-level delivery builds from our prior national investment over many decades and makes full use of the distributed capability in laser technology, the ubiquity of semiconductor diodes, high volume manufacturing markets, and U.S. capability in fusion science and nuclear engineering. The LIFE approach is based on the ignition evidence emerging from NIF and adopts a line-replaceable unit approach to ensure high plant availability and to allow evolution from available technologies and materials. Utilization of a proven physics platform for the ignition scheme is an essential component of an acceptably low-risk solution. The degree of coupling seen on NIF between driver and target performance mandates that little deviation be adopted from the NIF geometry and beamline characteristics. Similarly, the strong coupling between subsystems in an operational power plant mandates that a self-consistent solution be established via an integrated facility delivery project. The benefits of separability of the subsystems within an IFE plant (driver, chamber, targets, etc.) emerge in the operational phase of a power plant rather than in its developmental phase. An optimized roadmap for IFE delivery needs to account for this to avoid nugatory effort and inconsistent solutions. For LIFE, a system design has been established that could lead to an operating power plant by the mid-2020s, drawing from an integrated subsystem development program to demonstrate the required technology readiness on a time scale compatible with the construction plan. Much technical development work still remains, as does alignment of key stakeholder groups to this newly emerging development option. If the required timeline is to be met, then preparation of a viable program is required alongside the demonstration of ignition on NIF. This will enable timely analysis of the technical and economic case and establishment of the appropriate delivery partnership.

Dunne, A M

2010-11-30T23:59:59.000Z

387

Near-Infrared Optical Imaging of B16 Melanoma Cells via Low-Density Lipoprotein-Mediated Uptake and Delivery of High Emission Dipole Strength Tris[(porphinato)zinc(II)] Fluorophores  

Science Journals Connector (OSTI)

Shaw, J. M., Shaw, K. V., Yanovich, S., Iwanik, M., Futch, W. S., Rosowsky, A., and Schook, L. B. (1987) Delivery of lipophilic drugs using lipoproteins. ... Shaw, J. Michael; Shaw, Kala V.; Yanovich, Saul; Iwanik, Michael; Futch, William S.; Rosowsky, Andre; Schook, Lawrence B. ...

Sophia P. Wu; Intae Lee; P. Peter Ghoroghchian; Paul R. Frail; Gang Zheng; Jerry D. Glickson; Michael J. Therien

2005-04-30T23:59:59.000Z

388

Hydrogen Delivery InfrastructureHydrogen Delivery Infrastructure Option AnalysisOption Analysis  

E-Print Network [OSTI]

Converting NG/oil pipelines for GH delivery Option 3 Blending GH into NG pipelines Option 4* GH tube trailers Option 5* LH tank trucks Option 6 Use of novel H2 carriers (alanate; chemical hydride; liquid hydrocarbon as CA) -- NG distribution lines: gas companies usually use for Class 3 & 4 No odorants used in current H

389

Drug Therapy: Alzheimer's Disease  

Science Journals Connector (OSTI)

...provide evidence supporting the concept that vitamin E, as well as vitamin C, has a role in delaying the onset of Alzheimer's disease.– Memantine. Memantine, an N-methyl-D-aspartate antagonist recently approved by the Food and Drug Administration (FDA) for the treatment of moderate-to-severe Alzheimer's... The prevalence of Alzheimer's disease is predicted to reach 13.2 million cases in the United States. This article considers current therapeutic approaches for Alzheimer's disease. Optimal management requires accurate diagnosis, which is increasingly based on an understanding of pathophysiology. Neuroprotective strategies, cholinesterase inhibitors, psychopharmacologic agents that may reduce behavioral disturbances, and newer agents such as memantine are discussed.

Cummings J.L.

2004-07-01T23:59:59.000Z

390

Examination of Terminal Land Requirements for Hydrogen Delivery  

Broader source: Energy.gov [DOE]

Presentation by Jerry Gillette of Argonne National Laboratory at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007

391

H2A Delivery Components Model and Analysis  

Broader source: Energy.gov (indexed) [DOE]

Hydrogen Delivery Components Model Matt Ringer National Renewable Energy Laboratory February 8, 2005 Other Team Members: Mark Paster: DOE Marianne Mintz, Jerry Gillette, Jay Burke:...

392

H2A Delivery Scenario Model and Analyses  

Broader source: Energy.gov (indexed) [DOE]

Marianne Mintz and Jerry Gillette DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting February 8, 2005 2 Pioneering Science and Technology Office...

393

H2A Delivery: Miscellaneous Cost and H2 Losses  

Broader source: Energy.gov [DOE]

Presentation by Matt Ringer of the National Renewable Energy Laboratory at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007

394

H2A Delivery: Forecourt Compression & Storage Optimization (Part II)  

Broader source: Energy.gov [DOE]

Presentation by Matthew Hooks of TIAX at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007

395

,"North Carolina Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","North Carolina Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

396

,"South Dakota Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","South Dakota Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

397

,"North Dakota Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","North Dakota Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

398

,"New Hampshire Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","New Hampshire Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

399

,"Rhode Island Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","Rhode Island Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

400

,"New Jersey Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","New Jersey Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

,"West Virginia Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","West Virginia Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

402

Massachusetts Save Energy Now—State, Local, and Regional Delivery  

Broader source: Energy.gov [DOE]

Massachusetts Save Energy Now—State, Local, and Regional Delivery captures lost energy efficiency implementation by offering trainings, technical assistance, and information to industrial companies within the region.

403

Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery...  

Broader source: Energy.gov (indexed) [DOE]

Bulk Hydrogen Storage Strategic Directions for Hydrogen Delivery Workshop May 7-8, 2003 Crystal City, Virginia Breakout Session - Bulk Hydrogen Storage Main ThemesCaveats Bulk...

404

Office of Electricity Delivery and Energy Reliability | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Office of Electricity Delivery and Energy Reliability Community Guidelines for Energy Emergencies Community Guidelines for Energy Emergencies Read more Smart Grid Investments...

405

Percentage of Total Natural Gas Industrial Deliveries included...  

U.S. Energy Information Administration (EIA) Indexed Site

Industrial Price Percentage of Total Industrial Deliveries included in Prices Vehicle Fuel Price Electric Power Price Period: Monthly Annual Download Series History Download...

406

NREL: Hydrogen and Fuel Cells Research - Hydrogen Production and Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hydrogen Production and Delivery Hydrogen Production and Delivery Most of the hydrogen in the United States is produced by steam reforming of natural gas. For the near term, this production method will continue to dominate. Researchers at NREL are developing advanced processes to produce hydrogen economically from sustainable resources. NREL's hydrogen production and delivery R&D efforts, which are led by Huyen Dinh, focus on the following topics: Biological Water Splitting Fermentation Conversion of Biomass and Wastes Photoelectrochemical Water Splitting Solar Thermal Water Splitting Renewable Electrolysis Hydrogen Dispenser Hose Reliability Hydrogen Production and Delivery Pathway Analysis. Biological Water Splitting Certain photosynthetic microbes use light energy to produce hydrogen from

407

Robotic Intelligent System | GE Global Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imagine an intelligent system managing the surgical tool sterilization process in a hospital-ensuring safe delivery of care, enabling new levels of hospital efficiency and...

408

Reinforcement of energy delivery network against natural disaster events  

Science Journals Connector (OSTI)

Abstract Among all city infrastructures affected by natural disaster events, electric power grid is the most critical one. Most services on which disaster relief efforts depend, rely entirely on the availability of dependable and continuous supply of power. To achieve power grid resiliency against natural disasters, it is first necessary to perform a thorough analysis of interdependencies within the energy delivery network. This paper puts forth a graph-theoretic methodology based on fuzzy cognitive maps that models and analyzes the grid as an interconnected system of elements (i.e., energy resources and loads) that are connected through weighted and directional edges (i.e., lines and feeders). The developed model provides a mathematical framework for the analysis of the power grid during natural disaster events, and is used to devise optimal reinforcement strategies for the grid infrastructure via capacity enhancements and component reinforcement. The problem has been formulated as a constrained quadratic optimization one. The analysis and optimization approach are performed using abstract models so as to ensure the generic nature of the proposed methodology. A case study is presented using the IEEE 34-bus test distribution system. The system is mapped onto the floodplain map of the city of Boulder, CO, and is used to verify the applicability of the proposed methodology for grid reinforcement against flood hazards.

Salman Mohagheghi

2014-01-01T23:59:59.000Z

409

Drug Detection Study  

Office of Scientific and Technical Information (OSTI)

ORISE-07-NSEM-0544 ORISE-07-NSEM-0544 U.S. Department of Energy Office of Health, Safety and Security Office of Security Policy Drug Retention Times Center for Human Reliability Studies Oak Ridge Institute for Science and Education Operated by Oak Ridge Associated Universities For the U.S. Department of Energy Oak Ridge Associated Universities (ORAU) is a university consortium leveraging the scientific strength of major research institutions to advance science and education by partnering with national laboratories, government agencies, and private industry. ORAU manages the Oak Ridge Institute for Science and Education for the U.S. Department of Energy. The Oak Ridge Institute for Science and Education (ORISE) is a U.S. Department of Energy institute focusing on

410

Timely Delivery of Laser Inertial Fusion Energy Presentation prepared for  

E-Print Network [OSTI]

plant design · Delivery soon enough to make a difference to global energy imperatives. · Design basedTimely Delivery of Laser Inertial Fusion Energy Presentation prepared for Town Hall meeting must directly address the end-user requirement for commercial power 3 Plant Primary Criteria (partial

411

CIB White Paper on IDDS Integrated Design & Delivery Solutions  

E-Print Network [OSTI]

CIB White Paper on IDDS Integrated Design & Delivery Solutions Publication 328 ISBN 978-90-6363-060-7 #12;CIB White Paper on IDDS Page 1 of 15 CIB White Paper on IDDS Integrated Design & Delivery White Paper on IDDS Page 2 of 15 Table of Contents Introduction and Use of this White Paper

Amor, Robert

412

Patient-specific QA and delivery verification of scanned ion beam at NIRS-HIMAC  

SciTech Connect (OSTI)

Purpose: To evaluate a patient-specific QA program and system for constancy checking of a scanning delivery system developed at the National Institute of Radiological Sciences.Methods: For the patient-specific QA, all the planned beams are recalculated on a water phantom with treatment planning software (TPS). The recalculated dose distributions are compared with the measured distributions using a 2D ionization chamber array at several depths, and evaluated using gamma index analysis with criteria of 3% and 3 mm and a pass rate of 90%. For the constancy check, the authors developed the multiwire proportional chamber (MWPC), which can record the delivered 2D fluence images in a slice-by-slice manner. During irradiation for dosimetric QA with the 2D ionization chamber array and an accordion-type water phantom, the 2D fluence images are recorded using the MWPC in the delivery system. These recorded images are then compared to those taken in the treatment session to check the constancy check. This analysis also employs gamma index analysis using the same criteria as in the patient-specific QA. These patient-specific QA and constancy check evaluations were performed using the data of 122 patients.Results: In the patient-specific QA, the measured dose distributions agreed well with those calculated by the TPS, and the QA criteria were satisfied in all measurements. The additional check of the fluence comparison ensured the constancy of the delivered field during each treatment irradiation.Conclusions: The authors established a patient-specific QA program and additional check of delivery constancy in every treatment session. Fluence comparison is a strong tool for constancy checking of the delivery system.

Furukawa, Takuji; Inaniwa, Taku; Hara, Yousuke; Mizushima, Kota; Shirai, Toshiyuki; Noda, Koji [Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)] [Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)

2013-12-15T23:59:59.000Z

413

Office of Electricity Delivery &amp; Energy Reliability Contributors |  

Broader source: Energy.gov (indexed) [DOE]

Office of Electricity Delivery & Energy Reliability » Office of Office of Electricity Delivery & Energy Reliability » Office of Electricity Delivery & Energy Reliability Contributors Office of Electricity Delivery & Energy Reliability Contributors June 20, 2012 David Ortiz, OE-40 David Ortiz is Deputy Assistant Secretary for Energy Infrastructure Modeling and Analysis (EIMA) in the Department of Energy's Office of Electrici April 25, 2013 Eric Lightner June 22, 2011 Henry S. Kenchington, OE-50 Mr. Henry (Hank) Kenchington is Deputy Assistant Secretary (DAS) for the Advanced Grid Integration Division in the Department of Energy's Office of Electricity Delivery and Energy Reliability. He is responsible for the strategic management of the $3.4 billion Smart Grid Investment Grant program funded under the American Recovery and Reinvestment Act of 2009 to

414

National Electricity Delivery Division (NEDD) | Department of Energy  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) Timely, accurate and defensible policy and market analysis is a key ingredient to building and sustaining successful programs at DOE. The National Electricity Delivery Division coordinates OE's policy-related activities which include: Coordination of Federal Transmission Authorizations Section 1221(a) of EPACT added section 216(h) to the Federal Power Act, which requires that DOE act as the lead agency for purposes of coordinating all applicable Federal authorizations and related environmental reviews required to site an electric transmission facility. DOE and eight other Federal agencies have entered into a Memorandum of Understanding and DOE

415

Hydrogen Delivery: An Option to Ease the Transition  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delivery: Delivery: An Option to Ease the Transition Presentation at: The DOE Hydrogen and Fuel Cells Coordination Meeting Washington, D.C. June 3, 2003 John C. Winslow, Product Manager, Coal Fuels & Hydrogen National Energy Technology Laboratory Descriptor - include initials, /org#/date Hydrogen Delivery Today * Hydrogen infrastructure exists only for small merchant hydrogen markets in the chemical and refining industries * Current natural gas infrastructure consists of: - Pipelines - intermediate product storage - import terminals - rail, barge, and truck delivery U.S. Pipeline Mileage 0.7 2000 279 0 1000 2000 3000 Oil Nat Gas Hydrogen thousand miles Source: APCI, EIA, NEP Descriptor - include initials, /org#/date Comparison of Alternative Delivery Pathways Central H 2 production (coal)

416

Vectren Energy Delivery of Indiana (Gas) - Residential Energy Efficiency  

Broader source: Energy.gov (indexed) [DOE]

Vectren Energy Delivery of Indiana (Gas) - Residential Energy Vectren Energy Delivery of Indiana (Gas) - Residential Energy Efficiency Rebates Vectren Energy Delivery of Indiana (Gas) - Residential Energy Efficiency Rebates < Back Eligibility Construction Residential Savings Category Heating & Cooling Commercial Heating & Cooling Heating Home Weatherization Commercial Weatherization Sealing Your Home Ventilation Program Info State Indiana Program Type Utility Rebate Program Rebate Amount Attic Insulation: 40% of cost, up to $450 Wall/Ceiling Insulation: 40% of cost, up to $450 Duct Sealing: Total cost, up to $400 Boilers: $300 Furnace: $150 - $275 Programmable Thermostat: $20 Provider Vectren Energy Delivery of Indiana Vectren Energy Delivery offers its residential natural gas customers in Indiana rebates for the installation of certain high efficiency natural gas

417

Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate |  

Broader source: Energy.gov (indexed) [DOE]

Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate < Back Eligibility Construction Installer/Contractor Residential Savings Category Heating & Cooling Home Weatherization Construction Commercial Weatherization Commercial Heating & Cooling Design & Remodeling Program Info State Ohio Program Type Utility Rebate Program Rebate Amount Full Adoption of Energy Star (Version 2.5) Standards: $750 Vectren Gold Star - HERS rating of 70 or less: $750 Furnace: $300 Boiler: $500 Tankless Water Heater: $150 Storage Water Heater: $50-$150 Programmable Thermostat: $20 Provider Vectren Energy Delivery of Ohio Vectren Energy Delivery of Ohio offers a flat rebate to builders of residential single-family Energy Star certified homes that receive gas

418

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Broader source: Energy.gov (indexed) [DOE]

Electricity Electricity Delivery and Energy Reliability Categorical Exclusion Determinations: Office of Electricity Delivery and Energy Reliability Categorical Exclusion Determinations issued by Electricity Delivery and Energy Reliability. DOCUMENTS AVAILABLE FOR DOWNLOAD September 18, 2012 CX-009236: Categorical Exclusion Determination Dynasty Power, Inc. Export Authorization CX(s) Applied: B4.2 Date: 09/18/2012 Location(s): Canada Offices(s): Electricity Delivery and Energy Reliability September 18, 2012 CX-009406: Categorical Exclusion Determination Rainbow Energy Marketing Corporation CX(s) Applied: B4.2 Date: 09/18/2012 Location(s): CX: none Offices(s): Electricity Delivery and Energy Reliability June 12, 2012 CX-008821: Categorical Exclusion Determination NRG Power Marketing, LLC Docket EA-384

419

Office of Electricity Delivery and Energy Reliability  

Broader source: Energy.gov (indexed) [DOE]

Subtopic c. References: Subtopic c. References: 1. Thomas B. Johansson, Henry Kelly, Amulya K.N. Reddy, and Robert H. Williams, "Renewable Energy: Sources for Fuels and Electricity", Island Press, 1993 2. Patrick Takahashi and Andrew Trenka, "Ocean Thermal Energy Conversion", John Wiley & sons, 1996. *All references can be accessed at: http://archive.epri.com/oceanenergy/streamenergy.html#reports OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY 28. NATURAL DISASTER REDUCTION THROUGH TECHNOLOGY The U.S. electric power sector is a critical part of our society. Virtually all aspects of residential, industrial, and commercial activities depend on safe, reliable, and affordable electricity. Electricity is among the most infrastructure-intensive segments of the energy sector - the electricity grid includes a network of 5,000 power

420

Our Current Approach to Drug Abuse -- Progress, Problems, Proposals  

Science Journals Connector (OSTI)

...treatment settings as appropriate. The intensity of a treatment is often independent of its setting. In addition, systematic research on outcomes is essential to improve the cost effectiveness of treatment and determine what works for whom and why. Such a system would be affordable, could be integrated... Most drug-abuse experts and historians agree that we are in the declining phase of a drug epidemic that began about 30 years ago. Still, drug abuse remains one of the nation's critical domestic problems, linked to crime, neglect of children, family ...

Kleber H.D.

1994-02-03T23:59:59.000Z

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Dangerous Deception — Hiding the Evidence of Adverse Drug Effects  

Science Journals Connector (OSTI)

...to address these issues, and payers spend huge sums on the drug, despite the dearth of evidence that it is better than older, cheaper agents. The health care system has a hard time performing drug-safety analyses, in large part because it relies on the pharmaceutical industry to conduct most research... On September 30, the New York Times reported that the FDA had issued a warning that the antifibrinolytic drug aprotinin could cause renal failure, congestive heart failure, stroke, and death. Dr. Jerry Avorn writes that many aspects of the aprotinin saga ...

Avorn J.

2006-11-23T23:59:59.000Z

422

Abstract 4479: Influence of the blood-brain barrier on drug distribution and efficacy of PI3K/mTOR inhibitors  

Science Journals Connector (OSTI)

...Abstract 4479: Influence of the blood-brain barrier on drug distribution and efficacy...is influenced by the presence of blood-brain barrier (BBB). PI3K/mTOR/AKT is...with the former molecule optimized for brain delivery. Here the influence of the BBB...

Rajneet K. Oberoi; William F. Elmquist; Rajendar Mittapalli; Jenny Pokorny; Jann Sarkaria

2014-10-01T23:59:59.000Z

423

Project Delivery Acquisition and Contracting Plan for the Tank Farm Contractor  

SciTech Connect (OSTI)

This document is a plan presenting the process, strategies and approaches for vendor contracting by the Tank Farm Contractor. The plan focuses on contracting structures, practices, methods, and desired approaches in contracting. The U.S. Department of Energy (DOE), Office of River Protection (ORP) has contracted with the CH2M HILL Hanford Group, Inc. (CHG), as the Tank Farm Contractor (TFC), to support vitrification of Hanford Site tank waste by the Privatization Contractor. During Waste Feed Delivery Phase 1, waste will be retrieved from certain double-shell tanks and delivered to the Privatization Contractor to meet contract feed delivery requirements. Near-term project goals include upgrading infrastructure systems; retrieving and delivering the waste; and accepting the waste packages for interim onsite storage and disposal. Project Delivery includes individual projects assigned to provide the infrastructure and systems responsible to provide engineering, design, procurement, installation/construction, and testing/turnover of systems for retrieval of waste from Hanford double-shell tanks. This plan sets the requirements for projects work scope, contracting practices, structures, methods, and performance measurements. The plan is designed to integrate Life-Cycle Projects acquisitions and provide a consistent contracting approach. This effort will serve as a step improvement in contract reform implementing commercial practices into DOE projects.

MERCADO, L.C.

2000-04-22T23:59:59.000Z

424

DOE Hydrogen and Fuel Cells Program: 2008 Annual Progress Report - Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delivery Delivery Printable Version 2008 Annual Progress Report III. Delivery This section of the 2008 Progress Report for the DOE Hydrogen Program focuses on delivery. Each technical report is available as an individual Adobe Acrobat PDF. Download Adobe Reader. Hydrogen Delivery Sub-Program Overview, Rick Farmer, U.S. Department of Energy (PDF 218 KB) Hydrogen Delivery Infrastructure Options Analysis, TP Chen, Nexant, Inc. (PDF 242 KB) Hydrogen Delivery Infrastructure Analysis, Marrianne Mintz, Argonne National Laboratory (PDF 324 KB) Hydrogen Embrittlement of Pipelines: Fundamentals, Experiments, Modeling, Petros Sofronis, University of Illinois, Urbana-Champaign (PDF 686 KB) Materials Solutions for Hydrogen Delivery in Steel Pipeline, Subodh Das, Secat, Inc. (PDF 691 KB)

425

Recreation service delivery by local governments in the North West Province] / Victor Solomon Mogajane.  

E-Print Network [OSTI]

??Service delivery in all aspects of life is a major problem facing the local, provincial and national governments in South Africa. Service delivery, in particular… (more)

Mogajane, Victor Solomon

2011-01-01T23:59:59.000Z

426

2H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...  

Broader source: Energy.gov (indexed) [DOE]

pipelines for gaseous hydrogen delivery Option 2: Use of existing natural gas or oil pipelines for gaseous hydrogen delivery Option 3: Use of existing natural gas pipelines...

427

E-Print Network 3.0 - adenoviral gene delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for both inter and intra species gene therapy delivery in adults. The gene therapy vehicle is tolerated... cell potential Nonviral delivery of selected ... Source:...

428

Electric Power Delivery Testing Feasibility Study Task 6 Final Report  

SciTech Connect (OSTI)

This Final Report is covers the completion of the Electric Power Delivery Testing Feasibility Study. The objective of this project was to research, engineer, and demonstrate high-power laboratory testing protocols to accurately reproduce the conditions on the electric power grid representing both normal load switching and abnormalities such as short-circuit fault protection. Test circuits, equipment, and techniques were developed and proven at reduced power levels to determine the feasibility of building a large-scale high-power testing laboratory capable of testing equipment and systems at simulated high-power conditions of the U.S. power grid at distribution levels up through 38 kiloVolts (kV) and transmission levels up through 230 kV. The project delivered demonstrated testing techniques, high-voltage test equipment for load testing and synthetic short-circuit testing, and recommended designs for future implementation of a high-power testing laboratory to test equipment and systems, enabling increased reliability of the electric transmission and distribution grid.

Thomas Tobin

2009-07-01T23:59:59.000Z

429

Cybersecurity for Energy Delivery Systems (CEDS) Research Call...  

Office of Environmental Management (EM)

capabilities for the U.S energy infrastructure, including cyber secure integration of smart grid technologies. This Research Call includes four (4) areas of interest: Moving...

430

Comments of Cisco Systems to Office of Electricity Delivery and...  

Broader source: Energy.gov (indexed) [DOE]

More Documents & Publications NIST Activities in Support of the Energy Independence and Security Act (EISA) of 2007 A POLICY FRAMEWORK FOR THE 21st CENTURY GRID: Enabling Our...

431

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

on Best PracticesStandards Development are below. CEDS 2010 Peer Review - Advanced Security Acceleration Project for the Smart Grid - James Nutaro, ORNL.pdf CEDS 2010 Peer...

432

Computer controlled feed delivery system for feed trucks  

E-Print Network [OSTI]

of truck speed and feed characteristics. Tests were performed to ascertain the validity of two design concepts. The first design concept consisted of operating the bed conveyor proportional to the ground speed of the feed truck while the cross-conveyor... and the dispersing cylinders operated at a continuous speed. The second design concept consisted of operating both the bed and cross-conveyor proportional to ground speed of the feed truck while the dispersing cylinders operated at a continuous speed. The results...

Holt, Gregory Alan

2012-06-07T23:59:59.000Z

433

Integrated Ant Colony and Tabu Search approach for time dependent vehicle routing problems with simultaneous pickup and delivery  

Science Journals Connector (OSTI)

Today manufacturers have become much more concerned with the coordination of both manufacturing (of new products) and recycling (of reusable resources) operations. This requires simultaneous scheduling of both forward and reverse flows of goods over ... Keywords: Ant Colony System, Reverse logistics, Tabu Search algorithm, Time dependent vehicle routing problem, VRP with simultaneous pick-ups and deliveries (VRPSPD)

Tao Zhang; W. Art Chaovalitwongse; Yuejie Zhang

2014-07-01T23:59:59.000Z

434

Intracellular protein delivery activity of peptides derived from insulin-like growth factor binding proteins 3 and 5  

SciTech Connect (OSTI)

Insulin-like growth factor binding proteins (IGFBPs) have various IGF-independent cellular activities, including receptor-independent cellular uptake followed by transcriptional regulation, although mechanisms of cellular entry remain unclear. Herein, we focused on their receptor-independent cellular entry mechanism in terms of protein transduction domain (PTD) activity, which is an emerging technique useful for clinical applications. The peptides of 18 amino acid residues derived from IGFBP-3 and IGFBP-5, which involve heparin-binding regions, mediated cellular delivery of an exogenous protein into NIH3T3 and HeLa cells. Relative protein delivery activities of IGFBP-3/5-derived peptides were approximately 20-150% compared to that of the HIV-Tat peptide, a potent PTD. Heparin inhibited the uptake of the fusion proteins with IGFBP-3 and IGFBP-5, indicating that the delivery pathway is heparin-dependent endocytosis, similar to that of HIV-Tat. The delivery of GST fused to HIV-Tat was competed by either IGFBP-3 or IGFBP-5-derived synthetic peptides. Therefore, the entry pathways of the three PTDs are shared. Our data has shown a new approach for designing protein delivery systems using IGFBP-3/5 derived peptides based on the molecular mechanisms of IGF-independent activities of IGFBPs.

Goda, Natsuko [Division of Biophysics, International Graduate School of Arts and Sciences, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045 (Japan); Division of Structural Biology, Graduate School of Medicine, Kobe University, 7-5-1 Kusunokicho, Chuo-ku, Kobe, Hyogo 650-0017 (Japan); Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST) (Japan); Tenno, Takeshi [Division of Structural Biology, Graduate School of Medicine, Kobe University, 7-5-1 Kusunokicho, Chuo-ku, Kobe, Hyogo 650-0017 (Japan); Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510 (Japan); Inomata, Kosuke; Shirakawa, Masahiro [Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST) (Japan); Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510 (Japan); Tanaka, Toshiki [Graduate School of Material Science, OMOHI-College, Nagoya Institute of Technology, Gokiso-cho, Nagoya 466-8555 (Japan); Hiroaki, Hidekazu [Division of Biophysics, International Graduate School of Arts and Sciences, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045 (Japan); Division of Structural Biology, Graduate School of Medicine, Kobe University, 7-5-1 Kusunokicho, Chuo-ku, Kobe, Hyogo 650-0017 (Japan); Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST) (Japan)], E-mail: hiroakih@med.kobe-u.ac.jp

2008-08-01T23:59:59.000Z

435

Clinton plan to speed cancer drug approval  

Science Journals Connector (OSTI)

Clinton plan to speed cancer drug approval ... Accelerated approval and three other proposals "will affect at least 100 drugs now being studied," he notes, cutting FDA review time for some of these drugs from 12 months to six months. ...

1996-04-08T23:59:59.000Z

436

Report on AOAC, Narcotic and Dangerous Drugs  

Science Journals Connector (OSTI)

......Report on AOAC, narcotic and dangerous drugs. | Journal Article...Report on AOAC, Narcotic and Dangerous Drugs by Anthony Romano...Bureau of Narcotics and Dangerous Drugs, Miami, Florida 33132...substances affect- ing public health." The AOAC itself maintains......

Anthony Romano; Jr.

1972-05-01T23:59:59.000Z

437

FY13 Budget Request for the Office of Electricity Delivery and Energy Reliability  

Broader source: Energy.gov (indexed) [DOE]

Current Current Appropriation FY 2012 Enacted Appropriation FY 2013 Request Research and Development Clean Energy Transmission and Reliability 25,272 25,414 24,000 Electricity Systems Hub 20,000 Smart Grid Research and Development 28,188 23,909 14,400 Energy Storage 19,440 19,924 15,000 Cyber Security for Energy Delivery Systems 29,160 29,889 30,000 SUBTOTAL Research and Development 102,060 99,136 103,400 Permitting, Siting, and Analysis 6,000 6,976 6,000 Infrastructure Security and Energy Restoration 6,100 5,981 6,000 Program Direction 27,610 27,010 27,615 SUBTOTAL, Electricity Delivery and Energy Reliability 141,770 139,103 143,015 Transfer from State Department 100 Use of Prior Year Balances/Rescission -3,700 TOTAL, Electricity Delivery and Energy Reliability 138,170 139,103 143,015

438

THUMBS DOWN ON DRUG WAR WEAPON  

Science Journals Connector (OSTI)

THUMBS DOWN ON DRUG WAR WEAPON ... Mycoherbicides have been viewed as a potentially potent weapon in the worldwide war on illicit drugs. ...

CHERYL HOGUE

2011-12-05T23:59:59.000Z

439

Plan to speed up drug review approved  

Science Journals Connector (OSTI)

Plan to speed up drug review approved ... Proposed changes in the New Drug Application procedure will shorten review times, reduce paperwork, and save money ...

DAVID HANSON

1982-07-12T23:59:59.000Z

440

The Office of Electricity Delivery and Energy Reliability is Closely  

Broader source: Energy.gov (indexed) [DOE]

The Office of Electricity Delivery and Energy Reliability is The Office of Electricity Delivery and Energy Reliability is Closely Monitoring Hurricane Irene (2011) The Office of Electricity Delivery and Energy Reliability is Closely Monitoring Hurricane Irene (2011) August 25, 2011 - 11:13am Addthis The Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE) is closely monitoring Hurricane Irene as it travels up the U.S. coast and is publishing Situation Reports. Addthis Related Articles Sandy made landfall as a post-tropical cyclone on the southern coast of New Jersey near Atlantic City at 8 p.m. on October 29, with top sustained winds of 80 mph. | Photo courtesy of NOAA. Responding To Hurricane Sandy: DOE Situation Reports On November 7, a Nor'easter began to impact the Mid-Atlantic and Northeast with strong winds, rain or snow, and coastal flooding. | Photo courtesy of NOAA.

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Secretary Chu's Remarks as Prepared for Delivery at the Washington  

Broader source: Energy.gov (indexed) [DOE]

as Prepared for Delivery at the Washington as Prepared for Delivery at the Washington University Commencement Secretary Chu's Remarks as Prepared for Delivery at the Washington University Commencement May 21, 2010 - 12:00am Addthis Remarks of Secretary Steven Chu- As Prepared for Delivery Washington University Friday, May 21, 2010 Chancellor Mark Wrighton, the Board of Trustees, faculty, family, and friends here today, thank you for letting me share this wonderful day with you. It is a special privilege to return to the campus where my father began his career as a professor of chemical engineering. To the new graduates: Congratulations on your achievements. This year is the 40th anniversary of my own commencement. I know from personal experience that you will probably not remember what I will have said five years from today. I could stand here and read the phone book -

442

Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to Hydrogen to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results May 8, 2007 Amgad Elgowainy Argonne National Laboratory Comparison of Delivery Pathways- V1.0 vs. V2.0 2 1 3 i delivery by a Loading, the plant Version 1.0 character zed components for 3 pathways with single mode. conditioning and storage are at or adjacent to Liquid Hydrogen (LH) Truck H2 Production 100 or 1500 kg/d Compressed H2 (CH) Truck H2 Production 3 or 7 kpsi 100 or 1500 kg/d H2 Production Gaseous H2 Pipeline 100 or 1500 kg/d HDSAM V1.0 Estimates Delivery Cost for 3 Pathways 4 H2 H2 1 2 3 H2 Distribution and Ci I. Liquid H2 Distribution: HDSAM V2.0 Simulates Nine Pathways Production Production LH Terminal LH Terminal Production LH Terminal Transmission Transmission Distribution

443

EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts |  

Broader source: Energy.gov (indexed) [DOE]

EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts The Office of Environmental Management (EM) has 23 Indefinite Delivery/Indefinite Quantity (IDIQ) contracts to provide cleanup services at EM sites across the United States. The scope of work of the IDIQ contracts includes: environmental remediation deactivation, decommissioning, demolition and removal of contaminated facilities waste management regulatory compliance These nationwide, multiple-award IDIQ contracts allow EM sites to place timely, competitive and cost-effective task orders for environmental services with either large or small businesses, as determined by the complexity of the requirements. Twelve of the IDIQ contracts were awarded

444

Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel Technology  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

delivery of compressed hydrogen delivery of compressed hydrogen with advanced vessel technology Gene Berry Andrew Weisberg Salvador M. Aceves Lawrence Livermore National Laboratory (925) 422-0864 saceves@LLNL.GOV DOE and FreedomCar & Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop Washington, DC January 25, 2006 LLNL is developing innovative concepts for efficient containment of hydrogen in light duty vehicles concepts may offer advantages for hydrogen delivery Conformable containers efficiently use available space in the vehicle. We are pursuing multiple approaches to conformability High Strength insulated pressure vessels extend LH 2 dormancy 10x, eliminate boiloff, and enable efficiencies of flexible refueling (compressed/cryogenic H 2 /(L)H 2 ) The PVT properties of H

445

Oncor Electric Delivery Company LLC | Open Energy Information  

Open Energy Info (EERE)

Oncor Electric Delivery Company LLC Oncor Electric Delivery Company LLC (Redirected from Oncor Electric Delivery Company, LLC) Jump to: navigation, search Name Oncor Electric Delivery Company LLC Place Texas Service Territory Texas Website www.oncor.com/EN/Pages/de Green Button Landing Page www.smartmetertexas.com/C Green Button Reference Page www.emeter.com/smart-grid Green Button Implemented Yes Utility Id 44372 Utility Location Yes Ownership I NERC Location TRE NERC ERCOT Yes Activity Transmission Yes Activity Buying Transmission Yes Activity Distribution Yes Activity Buying Distribution Yes Alt Fuel Vehicle Yes Alt Fuel Vehicle2 Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it.

446

United Parcel Service Evaluates Hybrid Electric Delivery Vans...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Evaluation team evaluated the 12-month, in-service performance of six Class 4 hybrid electric delivery vans-fueled by regular diesel-and six comparable conventional diesel...

447

FedEx Express Gasoline Hybrid Electric Delivery Truck Evaluation...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

vehicles currently in service. FedEx Express has deployed 20 gasoline hybrid electric vehicles (gHEVs) on parcel delivery routes in the Sacramento and Los Angeles areas. This...

448

Agenda for the Hydrogen Delivery and Onboard Storage Analysis...  

Broader source: Energy.gov (indexed) [DOE]

- T. P. Chen, Nexant 2:45 pm Break 3:00 pm Hydrogen Delivery Demonstrations - Ed Kiczek, Air Products & Chemicals, Inc. 3:10 pm Pathway Cost Distributions: Fuel Pathway...

449

Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...  

Broader source: Energy.gov (indexed) [DOE]

8:15 H2A Delivery Model Changes and Discussion: Matt Hooks (TIAX LLC), Bruce Kelly (Nexant), Jerry Gillette (ANL), Matt Ringer (NREL), Amgad Elgowainy (ANL) 8:15...

450

,"New York Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

,,"(202) 586-8800",,,"182015 12:47:52 PM" "Back to Contents","Data 1: New York Natural Gas Deliveries to Electric Power Consumers (MMcf)" "Sourcekey","N3045NY2"...

451

Vacancy Announcements Posted for Hydrogen Production and Delivery Program  

Broader source: Energy.gov [DOE]

The Fuel Cell Technologies Office has posted two vacancy announcements for a position to serve as Program Manager for the Hydrogen Production and Delivery Program in the DOE EERE Fuel Cell Technologies Office. The closing date is October 28, 2014.

452

A vector-free microfluidic platform for intracellular delivery  

E-Print Network [OSTI]

Intracellular delivery of macromolecules is a challenge in research and therapeutic applications. Existing vector-based and physical methods have limitations, including their reliance on exogenous materials or electrical ...

Sharei, Armon Reza

453

Office of Electricity Delivery and Energy Reliability, OE-20  

Broader source: Energy.gov (indexed) [DOE]

6, 2012 Office of Electricity Delivery and Energy Reliability, OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585 RE: Comments for Consideration in...

454

Lamont Jackson Office of Electricity Delivery and Energy Reliability  

Energy Savers [EERE]

March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue, S.W. Washington, D.C....

455

Mr. Lamont Jackson Office of Electricity Delivery and Energy...  

Energy Savers [EERE]

March 28, 2012 Mr. Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585...

456

Lamont Jackson Office of Electricity Delivery and Energy Reliability  

Energy Savers [EERE]

March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, D.C. 20585...

457

Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM...  

Broader source: Energy.gov (indexed) [DOE]

Gaseous Forecourt kg Sum kg kg Energy Fue Other O&M Cap ta Indianapolis, Compressed Gas (5000 psi Delivery, 20% M arket Penetration, 850 kg day Station, 62 miles to City...

458

Liguid and Solid Carriers Group- Strategic Directions for Hydrogen Delivery Workshop  

Broader source: Energy.gov [DOE]

Targets, barriers and research and development priorities for solid and liquid hydrogen storage and delivery materials.

459

Studies of Monitoring and Diagnosis Systems for Substation Apparatus.  

E-Print Network [OSTI]

??Substation apparatus failure plays a major role in reliability of power delivery systems. Traditionally, most utilities perform regular maintenance in order to prevent equipment breakdown.… (more)

Liang, Yishan

2006-01-01T23:59:59.000Z

460

HTWOS and System Planning Briefing to DOE-HQ  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Management Plan Waste Feed Delivery Projects Plan ORP-Approved System Plan Assumptions Technology Development Roadmap WTP Contract WTP PMB WTP Flowsheet and Design Tank...

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Percentage of Total Natural Gas Commercial Deliveries included in Prices  

Gasoline and Diesel Fuel Update (EIA)

City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area May-13 Jun-13 Jul-13 Aug-13 Sep-13 Oct-13 View History U.S. 63.3 59.3 57.9 57.0 57.4 61.3 1983-2013 Alabama 71.7 71.0 68.5 68.2 68.4 66.7 1989-2013 Alaska 94.1 91.6 91.1 91.0 92.3 92.6 1989-2013 Arizona 84.0 83.0 81.6 80.3 82.8 82.7 1989-2013 Arkansas 37.8 28.3 28.1 28.6 26.7 28.0 1989-2013

462

Percentage of Total Natural Gas Industrial Deliveries included in Prices  

Gasoline and Diesel Fuel Update (EIA)

City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area May-13 Jun-13 Jul-13 Aug-13 Sep-13 Oct-13 View History U.S. 16.5 16.3 16.0 16.2 16.6 16.9 2001-2013 Alabama 22.1 21.7 21.6 22.8 22.0 22.7 2001-2013 Alaska 100.0 100.0 100.0 100.0 100.0 100.0 2001-2013 Arizona 13.4 15.7 15.3 13.8 13.7 13.9 2001-2013 Arkansas 1.7 1.4 1.2 1.4 1.3 1.5 2001-2013

463

Economic and Conservation Evaluation of Capital Renovation Projects: Harlingen Irrigation District Cameron County No. 1 Canal Meters and Telemetry Equipment, Impervious-Lining of Delivery Canals, Pipelines Replacing Delivery Canals, and On-Farm Delivery-Site Meters  

E-Print Network [OSTI]

, impervious-lining of delivery canals, 24" pipelines replacing delivery canals, and on-farm delivery-site meters). Sensitivity results for both the cost of water savings and cost of energy savings are presented for several important parameters. Expected cost...

Rister, M. Edward; Lacewell, Ronald D.; Sturdivant, Allen W.; Robinson, John R.C.; Popp, Michael C.; Ellis, John R.

464

Delivery quality assurance with ArcCHECK  

SciTech Connect (OSTI)

Radiation therapy requires delivery quality assurance (DQA) to ensure that treatment is accurate and closely follows the plan. We report our experience with the ArcCHECK phantom and investigate its potential optimization for the DQA process. One-hundred seventy DQA plans from 84 patients were studied. Plans were classified into 2 groups: those with the target situated on the diodes of the ArcCHECK (D plans) and those with the target situated at the center (C plans). Gamma pass rates for 8 target sites were examined. The parameters used to analyze the data included 3%/3 mm with the Van Dyk percent difference criteria (VD) on, 3%/3 mm with the VD off, 2%/2 mm with the VD on, and x/3 mm with the VD on and the percentage dosimetric agreement “x” for diode plans adjusted. D plans typically displayed maximum planned dose (MPD) on the cylindrical surface containing ArcCHECK diodes than center plans, resulting in inflated gamma pass rates. When this was taken into account by adjusting the percentage dosimetric agreement, C plans outperformed D plans by an average of 3.5%. ArcCHECK can streamline the DQA process, consuming less time and resources than radiographic films. It is unnecessary to generate 2 DQA plans for each patient; a single center plan will suffice. Six of 8 target sites consistently displayed pass rates well within our acceptance criteria; the lesser performance of head and neck and spinal sites can be attributed to marginally lower doses and increased high gradient of plans.

Neilson, Christopher; Klein, Michael; Barnett, Rob [London Regional Cancer Program, London Health Sciences Centre, London, Ontario (Canada); Yartsev, Slav, E-mail: slav.yartsev@lhsc.on.ca [London Regional Cancer Program, London Health Sciences Centre, London, Ontario (Canada)

2013-04-01T23:59:59.000Z

465

The overdose of drugs in Japan  

Science Journals Connector (OSTI)

... spenders on prescription drugs. Among the top-selling drugs are anti-cancer agents peculiar to Japan that are of questionable efficacy and yet have sales of hundreds of millions of dollars ... -cancer drugs in other developed nations. Moreover, several of the drugs sold only in Japan have serious side effects. Justification of these contentions is to be found in Tables ...

Masanori Fukushima

1989-12-28T23:59:59.000Z

466

Energy-efficient content delivery networks using cluster shutdown  

Science Journals Connector (OSTI)

Abstract Content delivery networks (CDNs) are an important class of Internet-scale distributed systems that deliver web, streaming, and application content to end users. A commercial CDN could comprise hundreds of thousands of servers deployed in over thousand clusters across the globe and incurs significant energy costs for powering and cooling their servers. Since energy costs are a significant component of the total operating expense of a CDN, we propose and explore a novel technique called cluster shutdown that turns off an entire cluster of servers of a CDN that is deployed within a data center. By doing so, cluster shutdown saves not just the power consumed by the servers but also the power needed for cooling those servers. We present an algorithm for cluster shutdown that is based on realistic power models for servers and cooling equipment and can be implemented as a part of the global load balancer of a CDN. We evaluate our technique using extensive real-world traces from a large commercial CDN to show that cluster shutdown can reduce the system-wide energy usage by 67%. Further, much of the energy savings are obtainable without sacrificing either bandwidth costs or end-user performance. In addition, 79% of the optimal savings are attainable even if each cluster is limited to at most one shutdown per day, reducing the required operational overhead. Finally, we argue that cluster shutdown has intrinsic architectural advantages over the well-studied server shutdown techniques in the CDN context, and show that it saves more energy than server shutdown in a wide range of operating regimes.

Vimal Mathew; Ramesh K. Sitaraman; Prashant Shenoy

2014-01-01T23:59:59.000Z

467

Strategic Directions for Hydrogen Delivery Workshop Proceedings  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

W W W o o r r k k s s h h o o p p P P r r o o c c e e e e d d i i n n g g s s M M a a y y 7 7 - - 8 8 , , 2 2 0 0 0 0 3 3 C C r r y y s s t t a a l l C C i i t t y y M M a a r r r r i i o o t t t t A A r r l l i i n n g g t t o o n n , , V V A A S S p p o o n n s s o o r r e e d d b b y y U U . . S S . . D D e e p p a a r r t t m m e e n n t t o o f f E E n n e e r r g g y y O O f f f f i i c c e e o o f f E E n n e e r r g g y y E E f f f f i i c c i i e e n n c c y y a a n n d d R R e e n n e e w w a a b b l l e e E E n n e e r r g g y y O O f f f f i i c c e e o o f f H H y y d d r r o o g g e e n n , , F F u u e e l l C C e e l l l l s s , , a a n n d d I I n n f f r r a a s s t t r r u u c c t t u u r r e e T T e e c c h h n n o o l l o o g g i i e e s s P P r r o o g g r r a a m m Strategic Directions for Hydrogen Delivery Workshop i May 2003 Table of Contents INTRODUCTION ...........................................................................................................................................................................................1 BACKGROUND.............................................................................................................................................................................................1

468

IDC System Specification Document.  

SciTech Connect (OSTI)

This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris

Clifford, David J.

2014-12-01T23:59:59.000Z

469

ELECTRICITY DELIVERY AND ENERGY RELIABILITY Appropriation Overview  

Office of Environmental Management (EM)

value-added synchrophasor applications for transmission owners, expansion of university research in mathematics for power systems, the development and application of risk...

470

Strategic Directions for Hydrogen Delivery Workshop Proceedings  

Broader source: Energy.gov (indexed) [DOE]

including water or oil pipelines for hydrogen transport Assess viability of natural gas safety systems when hydrogen is introduced Conduct field demonstra- tion of hydrogen...

471

Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan  

Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

Natural Gas Delivery Natural Gas Delivery Vans Support McShan Florist to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Facebook Tweet about Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Twitter Bookmark Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Google Bookmark Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Delicious Rank Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Digg Find More places to share Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on AddThis.com... May 25, 2012 Natural Gas Delivery Vans Support McShan Florist W atch how a Dallas, Texas, florist reduces emissions and saves money

472

Set-Aside EM Nation-Wide Indefinite Delivery/Indefinite Quantity Contracts  

Broader source: Energy.gov (indexed) [DOE]

SET-ASIDE EM NATION-WIDE SET-ASIDE EM NATION-WIDE INDEFINITE DELIVERY/INDEFINITE QUANTITY CONTRACTS Contractor Name Team Members/Principal Subcontractors Clauss Construction AECOM, Inc. Cavanagh Services Group, Inc. EnergX, LLC Dynamic Management Solutions, LLC (DMS) CA - LLC Member Restoration Services, Inc, LLC Member Wastren Advantage, Inc. - LLC Member SAIC Bartlett Services, Inc. Siempelkamp Nuclear Services Gonzales-Stoller Remediation Services, LLC JG Management Systems, Inc. - LLC Member (Protégé) The S.M. Stoller Corporation - LLC Member (Mentor) AET Environmental, Inc. ALS Laboratory Group AquaTierra Associates, Inc. DBA Weiss Assoc. ARCADIS U.S., Inc. AREVA Federal Services, LLC

473

Patricia Hoffman Assistant Secretary Office of Electricity Delivery and Energy Reliability  

Broader source: Energy.gov (indexed) [DOE]

Patricia Hoffman Assistant Secretary Office of Electricity Delivery and Energy Reliability U.S. Department of Energy Room 8H033 1000 Independence Avenue, SW Washington, DC 20585 Subject: DOE RFI DOE RFI 2010-23251 - Addressing Policy and Logistical Challenges to Smart Grid Implementation Dear Assistant Secretary Hoffman, The Galvin Electricity Initiative commends the Department of Energy for reaching out to key stakeholders to obtain input and comments on ways to improve electricity service. Your questions were comprehensive and should provide insights on ways to produce specific consumer benefits through the application of innovative technology, system design concepts, and enabling policies. The Galvin Electricity Initiative, a non-profit organization, has dedicated

474

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Broader source: Energy.gov (indexed) [DOE]

November 4, 2010 November 4, 2010 CX-004397: Categorical Exclusion Determination The Padlock Project CX(s) Applied: A1, A9, A11, B1.2, B1.7 Date: 11/04/2010 Location(s): Pullman, Washington Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory October 27, 2010 CX-004331: Categorical Exclusion Determination Long Island Smart Energy Corridor CX(s) Applied: A1, A9, A11 Date: 10/27/2010 Location(s): Stony Brook, New York Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory October 27, 2010 CX-004330: Categorical Exclusion Determination Long Island Smart Energy Corridor CX(s) Applied: A9, A11, B3.6, B4.4, B5.1 Date: 10/27/2010 Location(s): Farmingdale, New York Office(s): Electricity Delivery and Energy Reliability, National Energy

475

Design-Build Project Delivery | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Design-Build Project Delivery Design-Build Project Delivery Design-Build Project Delivery October 16, 2013 - 4:46pm Addthis Renewable energy must be integrated into each of the design phases. Noting that any agency may have specific processes during the development of a construction project, this section discusses key issues in the following phases of the design-build process: Planning and Programming Request for Qualifications Request for Proposal Construction Contract Design and Build Integrating renewable energy into design-bid-build strategy involves a few different approaches, which are covered in the main building design section of this guide. Planning and Programming The planning and programming phase should look the same regardless of whether the project is design-bid-build or design-build. An early team is

476

Vectren Energy Delivery of Ohio (Gas) - Commercial Energy Efficiency  

Broader source: Energy.gov (indexed) [DOE]

Ohio (Gas) - Commercial Energy Ohio (Gas) - Commercial Energy Efficiency Rebates Vectren Energy Delivery of Ohio (Gas) - Commercial Energy Efficiency Rebates < Back Eligibility Commercial Industrial Savings Category Heating & Cooling Commercial Heating & Cooling Heating Other Commercial Weatherization Maximum Rebate Boilers: $5,000 Boiler Tune-Up: $250 Custom Incentives: 30% of the total project cost or $25,000/project Program Info State Ohio Program Type Utility Rebate Program Rebate Amount Boilers: 25% of cost Boiler Tune-Up: 50% of cost Furnace: $200 Programmable Thermostat: $20 Custom Incentives: $0.75/therm (less than 7500 therm savings) or $1/therm (greater than 7500 therm savings) calculated based on first year energy savings. Provider Vectren Energy Delivery of Ohio Vectren Energy Delivery offers commercial natural gas customers in Ohio

477

Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Efficiency  

Broader source: Energy.gov (indexed) [DOE]

Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Efficiency Rebates Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Efficiency Rebates < Back Eligibility Commercial Fed. Government Local Government Nonprofit State Government Savings Category Heating & Cooling Commercial Heating & Cooling Heating Other Commercial Weatherization Appliances & Electronics Water Heating Maximum Rebate Boilers: $5,000 Boiler Modulating Burner Control: $5,000 Infrared Heater: $700 Custom: Contact Vectren Program Info State Indiana Program Type Utility Rebate Program Rebate Amount Boilers: $4/MMbtu Boiler Modulating Burner Control: up to $5000 Boiler Reset Control or Tune-Up: $250 Boiler Tune-up: $200 Furnace: $150 - $275 Tank Water Heater: $125 - $150 Tankless Water Heater: $150

478

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Broader source: Energy.gov (indexed) [DOE]

February 9, 2010 February 9, 2010 CX-000760: Categorical Exclusion Determination Amber Kinetics Flywheel Energy Storage Demonstration CX(s) Applied: B3.6 Date: 02/09/2010 Location(s): Freemont, California Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory February 8, 2010 CX-000762: Categorical Exclusion Determination Eastern Interconnection Planning Collaborative CX(s) Applied: A9 Date: 02/08/2010 Location(s): Morristown, Pennsylvania Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory February 8, 2010 CX-000764: Categorical Exclusion Determination Dynamic Line Rating Project CX(s) Applied: B3.11, B4.6 Date: 02/08/2010 Location(s): Texas Office(s): Electricity Delivery and Energy Reliability, National Energy

479

Deputy Secretary Poneman's Remarks at TERI - As Prepared for Delivery |  

Broader source: Energy.gov (indexed) [DOE]

Deputy Secretary Poneman's Remarks at TERI - As Prepared for Deputy Secretary Poneman's Remarks at TERI - As Prepared for Delivery Deputy Secretary Poneman's Remarks at TERI - As Prepared for Delivery July 18, 2011 - 6:15pm Addthis U.S. Deputy Secretary of Energy Daniel Poneman Remarks As Prepared for Delivery at TERI Monday, July 18, 2011 New Delhi, India Good morning. Thank you, Mr. Desai for the introduction. And thank you to TERI for hosting me this afternoon. I want to acknowledge the leadership TERI is already showing in advancing energy research and in fostering a constructive dialogue on issues that are critical to the people of India and to the world. We are grateful for your commitment and dedication, and for the work that you do every day. Before I begin my remarks today, I want to take a moment on behalf of the

480

Oncor Electric Delivery - Government and Education Facilities Program |  

Broader source: Energy.gov (indexed) [DOE]

Oncor Electric Delivery - Government and Education Facilities Oncor Electric Delivery - Government and Education Facilities Program Oncor Electric Delivery - Government and Education Facilities Program < Back Eligibility Institutional Local Government Schools Tribal Government Savings Category Home Weatherization Commercial Weatherization Heating & Cooling Commercial Heating & Cooling Cooling Other Construction Heat Pumps Appliances & Electronics Commercial Lighting Lighting Manufacturing Insulation Design & Remodeling Windows, Doors, & Skylights Program Info State Texas Program Type Utility Rebate Program Rebate Amount Chillers (Metro): $225.72/kW plus $0.07/kWh Chillers (Non-Metro): $219.82/kW plus $0.08/kWh DX HVAC (Metro): $191.15/kW plus $0.06/kWh DX HVAC (Non-Metro): $219.82/kW plus $0.07/kWh Geothermal (Metro): $251.45/kW plus $0.08/kWh

Note: This page contains sample records for the topic "drug delivery systems" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Oncor Electric Delivery - Large Commercial and Industrial Rebate Program |  

Broader source: Energy.gov (indexed) [DOE]

Oncor Electric Delivery - Large Commercial and Industrial Rebate Oncor Electric Delivery - Large Commercial and Industrial Rebate Program Oncor Electric Delivery - Large Commercial and Industrial Rebate Program < Back Eligibility Commercial Construction Industrial Installer/Contractor Institutional Local Government Schools State Government Savings Category Heating & Cooling Commercial Heating & Cooling Cooling Manufacturing Other Heat Pumps Appliances & Electronics Commercial Lighting Lighting Home Weatherization Insulation Design & Remodeling Windows, Doors, & Skylights Solar Buying & Making Electricity Water Heating Wind Maximum Rebate General: 20% of the incentive budget in a given budget year Contact Oncor for additional details Program Info State Texas Program Type Utility Rebate Program Rebate Amount DX Air Conditioning: $285.30/kW; $0.09/kWh

482

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Broader source: Energy.gov (indexed) [DOE]

August 20, 2010 August 20, 2010 CX-003473: Categorical Exclusion Determination Pacific Northwest Smart Grid Demonstration CX(s) Applied: A1, A9, A11, B1.7, B4.4, B4.7, B4.11, B5.1 Date: 08/20/2010 Location(s): Pullman, Washington Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory August 17, 2010 CX-003429: Categorical Exclusion Determination Oswego County BOCES Wind Turbine Model Project CX(s) Applied: A9, B1.15, B5.1 Date: 08/17/2010 Location(s): Mexico, New York Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory August 5, 2010 CX-003312: Categorical Exclusion Determination Power Grid Reliability and Security ? Phase II CX(s) Applied: A9, A11 Date: 08/05/2010 Location(s): Pullman, Washington Office(s): Electricity Delivery and Energy Reliability, National Energy

483

Competition Advocates and Task-Order and Delivery Order Ombudsman |  

National Nuclear Security Administration (NNSA)

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484

Tank Farms and Waste Feed Delivery - 12507  

SciTech Connect (OSTI)

The mission of the Department of Energy's Office of River Protection (ORP) is to safely retrieve and treat the 56 million gallons of Hanford's tank waste and close the Tank Farms to protect the Columbia River. Our discussion of the Tank Farms and Waste Feed Delivery will cover progress made to date with Base and Recovery Act funding in reducing the risk posed by tank waste and in preparing for the initiation of waste treatment at Hanford. The millions of gallons of waste are a by-product of decades of plutonium production. After irradiated fuel rods were taken from the nuclear reactors to the processing facilities at Hanford they were exposed to a series of chemicals designed to dissolve away the rod, which enabled workers to retrieve the plutonium. Once those chemicals were exposed to the fuel rods they became radioactive and extremely hot. They also couldn't be used in this process more than once. Because the chemicals are caustic and extremely hazardous to humans and the environment, underground storage tanks were built to hold these chemicals until a more permanent solution could be found. The underground storage tanks range in capacity from 55,000 gallons to more than 1 million gallons. The tanks were constructed with carbon steel and reinforced concrete. There are eighteen groups of tanks, called 'tank farms', some having as few as two tanks and others up to sixteen tanks. Between 1943 and 1964, 149 single-shell tanks were built at Hanford in the 200 West and East Areas. Heat generated by the waste and the composition of the waste caused an estimated 67 of these single-shell tanks to leak into the ground. Washington River Protection Solutions is the prime contractor responsible for the safe management of this waste. WRPS' mission is to reduce the risk to the environment that is posed by the waste. All of the pumpable liquids have been removed from the single-shell tanks and transferred to the double-shell tanks. What remains in the single-shell tanks are solid and semi-solid wastes. Known as salt-cakes, they have the consistency of wet beach sand. Some of the waste resembles small broken ice, or whitish crystals. Because the original pumps inside the tanks were designed to remove only liquid waste, other methods have been developed to reach the remaining waste. Access to the tank waste is through long, typically skinny pipes, called risers, extending out of the tanks. It is through these pipes that crews are forced to send machines and devices into the tanks that are used to break up the waste or push it toward a pump. These pipes range in size from just a few inches to just over a foot in diameter because they were never intended to be used in this manner. As part of the agreement regulating Hanford cleanup, crews must remove at least 99% of the material in every tank on the site, or at least as much waste that can be removed based on available technology. To date, seven single-shell tanks have been emptied, and work is underway in another 10 tanks in preparation for additional retrieval activities. Two barriers have been installed over single-shell tanks to prevent the intrusion of surface water down to the tanks, with additional barriers planned for the future. Single and double-shell tank integrity analyses are ongoing. Because the volume of the waste generated through plutonium production exceeded the capacity of the single-shell tanks, between 1968 and 1986 Hanford engineers built 28 double-shell tanks. These tanks were studied and made with a second shell to surround the carbon steel and reinforced concrete. The double-shell tanks have not leaked any of their waste. (authors)

Fletcher, Thomas; Charboneau, Stacy; Olds, Erik [US DOE (United States)

2012-07-01T23:59:59.000Z

485

Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance  

E-Print Network [OSTI]

as: Wu: Drug metabolizing enzyme activities versus geneticRoles for Old Molecules: Enzymes in Personalized Medicine,Access Drug metabolizing enzyme activities versus genetic

Wu, Alan HB

2011-01-01T23:59:59.000Z

486

Delivery, design, and mechanism of antimicrobial peptides  

E-Print Network [OSTI]

Each year, 2 million people contract hospital-acquired bacterial infections, which causes the death of 100,000 patients and costs the US healthcare system over $21 billion. These infections have become dangerously resistant ...

Chau, Tanguy

2010-01-01T23:59:59.000Z

487

Office of Electricity Delivery and Energy Reliability FY 2014 Budget Request  

Broader source: Energy.gov (indexed) [DOE]

FY 2014 Budget Request (discretionary dollars in thousands) FY 2012 Current Appropriation FY 2013 Annualized Continuing Resolution FY 2014 Request Clean Energy Transmission and Reliability 24,665 25,569 32,000 Transmission Reliability and Renewables Integration 15,482 16,049 18,000 Advanced Modeling Grid Research 9,183 9,520 10,000 Energy Systems Predictive Capability - - 4,000 Smart Grid 23,203 24,055 14,400 Smart Grid 19,336 24,055 14,400 Power Electronics 3,867 0 0 Energy Storage 19,336 20,046 15,000 Cybersecurity for Energy Delivery Systems 29,007 30,072 38,000 Electricity Systems Hub 0 0 20,000 National Electricity Delivery* 6,976 7,019 6,000 Infrastructure Security and Energy Restoration 5,981 6,018 16,000 Infrastructure Security and Energy Restoration 5,981 6,018 6,000

488

Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Office of Electricity Delivery & Energy Reliability FY 2012 Budget Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Presentation by Patricia Hoffman of the Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request. OE's FY 2012 budget request represents a strong commitment to modernizing the grid and providing the reliable, affordable, and secure electric power needed to expand economic recovery enable sources Office of Electricity Delivery and Energy Reliability recovery, the transition to renewable energy sources, and achieve the President's clean energy goals. Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation More Documents & Publications

489

Lamont Jackson Office of Electricity Delivery and Energy Reliability  

Broader source: Energy.gov (indexed) [DOE]

March 28, 2012 March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue, S.W. Washington, D.C. 20585 OE Docket No. RRTT-IR-001 Submitted via email to: Lamont.Jackson@hq.doe.gov COMMENTS OF THE AMERICAN WIND ENERGY ASSOCIATION ON THE DEPARTMENT OF ENERGY'S REQUEST FOR INFORMATION RELATED TO THE PERMITTING OF TRANSMISSION LINES Dear Mr. Jackson, The American Wind Energy Association 1 (AWEA) appreciates the opportunity to provide comments to the Department of Energy's Office of Electricity Delivery and Energy Reliability (DOE) on its request for information

490

Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Permeability and Permeability and Integrity of Hydrogen Delivery Pipelines Z. Feng*, L.M. Anovitz*, J.G. Blencoe*, S. Babu*, and P. S. Korinko** * Oak Ridge National Laboratory * Savannah River National Laboratory August 30, 2005 2 OAK RIDGE NATIONAL LABORATORY U. S. DEPARTMENT OF ENERGY Partners and Collaborators * Oak Ridge National Laboratory - Project lead * Savannah River National Laboratory - Low H 2 pressure permeation test * Edison Welding Institute - Pipeline materials * Lincoln Electric Company - Welding electrode and weld materials for pipelines * Trans Canada - Commercial welding of pipelines and industry expectations * DOE Pipeline Working Group and Tech Team activities - FRP Hydrogen Pipelines - Materials Solutions for Hydrogen Delivery in Pipelines - Natural Gas Pipelines for Hydrogen Use

491

Strategies and Project Delivery Methods for Captial Improvement Projects  

E-Print Network [OSTI]

David White, Regional Sales Manager, McKinstry STRATEGIES AND PROJECT DELIVERY METHODS FOR CAPITAL IMPROVEMENT PROJECTS ESL-KT-14-11-10 CATEE 2014: Clean Air Through Efficiency Conference, Dallas, Texas Nov. 18-20 Overview/Challenge • When you...% of construction time and reduce change costs* On average Design-Build saves over 31% on project schedule compared to traditional delivery methods – Construction Industry Institute ESL-KT-14-11-10 CATEE 2014: Clean Air Through Efficiency Conference, Dallas, Texas...

White, D.

2014-01-01T23:59:59.000Z

492

FCT Systems Analysis: Analysis Methodologies  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Analysis Methodologies to Analysis Methodologies to someone by E-mail Share FCT Systems Analysis: Analysis Methodologies on Facebook Tweet about FCT Systems Analysis: Analysis Methodologies on Twitter Bookmark FCT Systems Analysis: Analysis Methodologies on Google Bookmark FCT Systems Analysis: Analysis Methodologies on Delicious Rank FCT Systems Analysis: Analysis Methodologies on Digg Find More places to share FCT Systems Analysis: Analysis Methodologies on AddThis.com... Home Analysis Methodologies Resource Analysis Technological Feasibility & Cost Analysis Environmental Analysis Delivery Analysis Infrastructure Development & Financial Analysis Energy Market Analysis DOE H2A Analysis Scenario Analysis Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells Technology Validation

493

Adulteration of Drugs-of-Abuse Specimens  

Science Journals Connector (OSTI)

Persons abusing drugs attempt to adulterate urine specimens in ... fluid and various detoxifying agents available through the Internet is a common practice. Household chemicals such ... mask drug testing if the c...

Amitava Dasgupta

2005-01-01T23:59:59.000Z

494

Vetting Threats To Safe Drug Supplies  

Science Journals Connector (OSTI)

Vetting Threats To Safe Drug Supplies ... Representatives from government, drug companies, and national and international law enforcement agencies struggled to characterize what all agree is a large, growing, and frustratingly nebulous threat to public health and safety. ...

RICK MULLIN

2012-04-01T23:59:59.000Z

495

Prostate drug Proscar cleared for marketing  

Science Journals Connector (OSTI)

Prostate drug Proscar cleared for marketing ... The Food & Drug Administration has approved marketing of a pill developed by Merck & Co., Rahway, N.J., as an alternative to surgery for treating enlargement of the prostate gland. ...

STEPHEN STINSON

1992-06-29T23:59:59.000Z

496

The pipeline and future of drug development in schizophrenia  

E-Print Network [OSTI]

The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

Gray, J A; Roth, B L

2007-01-01T23:59:59.000Z

497

Flow cytometry aids basic cell biology research and drug discovery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Life Technologies Corporation and LANL have released the Attune® Acoustic Focusing Cytometer, featuring a reduced footprint, reduced consumables, and an affordable price. April 3, 2012 Attune® Acoustic Focusing Cytometer The Attune® Acoustic Focusing Cytometer achieves sample throughput at rates over 10 times faster than other cytometers-up to 1,000 μL per minute. In December 2009, Life Technologies Corporation announced the release of the Attune® Acoustic Focusing Cytometer, a first-of-its-kind cytometer system based on technology developed at Los Alamos National Laboratory (LANL). Examining cells has never been clearer with LANL's use of acoustic waves

498

Process management applications in biopharmaceutical drug production  

E-Print Network [OSTI]

Genzyme's manufacturing and supply chain organization is responsible for the production and delivery of medically necessary medicines for patients with rare diseases around the world. Because of the nature of the products ...

Smith, Stephen E

2011-01-01T23:59:59.000Z

499

Cryogenic System Revised June 1994  

E-Print Network [OSTI]

Chapter 9. Cryogenic System Revised June 1994 9.1. Introduction 9.2. Heat Loads and Refrigeration Duties -- 175 -- #12; 176 Cryogenic System #12; Cryogenic System 177 9.3. Two Phase Helium Cooling 9.4. The Refrigerator and Control #12; 178 Cryogenic System 9.5. Cryogen Delivery and Control 9.6. Three Cooling

Brookhaven National Laboratory - Experiment 821

500

Drugs: A tangled web of targets  

Science Journals Connector (OSTI)

... was a good year. The US Food and Drug Administration (FDA) had just approved memantine, the first in a class of drugs that reduces abnormal brain activity. Scientists had ... based on each, and the field seemed to be moving in the right direction. Memantine is one of several drugs on the market in Europe and the United States that ...

Lauren Gravitz

2011-07-13T23:59:59.000Z