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1

Detection and Repair of Ionizing Radiation-Induced DNA Double Strand Breaks: New Developments in Nonhomologous End Joining  

SciTech Connect (OSTI)

DNA damage can occur as a result of endogenous metabolic reactions and replication stress or from exogenous sources such as radiation therapy and chemotherapy. DNA double strand breaks are the most cytotoxic form of DNA damage, and defects in their repair can result in genome instability, a hallmark of cancer. The major pathway for the repair of ionizing radiation-induced DSBs in human cells is nonhomologous end joining. Here we review recent advances on the mechanism of nonhomologous end joining, as well as new findings on its component proteins and regulation.

Wang, Chen [Departments of Biochemistry and Molecular Biology and Oncology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary (Canada)] [Departments of Biochemistry and Molecular Biology and Oncology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary (Canada); Lees-Miller, Susan P., E-mail: leesmill@ucalgary.ca [Departments of Biochemistry and Molecular Biology and Oncology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary (Canada)

2013-07-01T23:59:59.000Z

2

The Impact of Individual In Vivo Repair of DNA Double-Strand Breaks on Oral Mucositis in Adjuvant Radiotherapy of Head-and-Neck Cancer  

SciTech Connect (OSTI)

Purpose: To evaluate the impact of individual in vivo DNA double-strand break (DSB) repair capacity on the incidence of severe oral mucositis in patients with head-and-neck cancer undergoing adjuvant radiotherapy (RT) or radiochemotherapy (RCT). Patients and Methods: Thirty-one patients with resected head-and-neck cancer undergoing adjuvant RT or RCT were examined. Patients underwent RT of the primary tumor site and locoregional lymph nodes with a total dose of 60-66 Gy (single dose 2 Gy, five fractions per week). Chemotherapy consisted of two cycles of cisplatin and 5-fluorouracil. To assess DSB repair, {gamma}-H2AX foci in blood lymphocytes were quantified before and 0.5 h, 2.5 h, 5 h, and 24 h after in vivo radiation exposure (the first fraction of RT). World Health Organization scores for oral mucositis were documented weekly and correlated with DSB repair. Results: Sixteen patients received RT alone; 15 patients received RCT. In patients who developed Grade {>=} 3 mucositis (n = 18) the amount of unrepaired DSBs 24 h after radiation exposure and DSB repair half-times did not differ significantly from patients with Grade {<=}2 mucositis (n = 13). Patients with a proportion of unrepaired DSBs after 24 h higher than the mean value + one standard deviation had an increased incidence of severe oral mucositis. Conclusions: Evaluation of in vivo DSB repair by determination of {gamma}-H2AX foci loss is feasible in clinical practice and allows identification of patients with impaired DSB repair. The incidence of oral mucositis is not closely correlated with DSB repair under the evaluated conditions.

Fleckenstein, Jochen, E-mail: rajfle@uks.eu [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Kuehne, Martin; Seegmueller, Katharina; Derschang, Sarah; Melchior, Patrick [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Graeber, Stefan [Institute for Medical Biometry, Epidemiology und Medical Informatics (IMBEI), Saarland University Medical School, Homburg (Germany); Fricke, Andreas; Ruebe, Claudia E.; Ruebe, Christian [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany)

2011-12-01T23:59:59.000Z

3

Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions  

SciTech Connect (OSTI)

To test the contribution of homologous recombinational repair (HRR) in repairing DNA damaged sites induced by high-energy iron ions, we used: (1) HRR-deficient rodent cells carrying a deletion in the RAD51D gene and (2) syngeneic human cells impaired for HRR by RAD51D or RAD51 knockdown using RNA interference. We show that in response to iron ions, HRR contributes to cell survival in rodent cells, and that HRR-deficiency abrogates RAD51 foci formation. Complementation of the HRR defect by human RAD51D rescues both enhanced cytotoxicity and RAD51 foci formation. For human cells irradiated with iron ions, cell survival is decreased, and, in p53 mutant cells, the levels of mutagenesis are increased when HRR is impaired. Human cells synchronized in S phase exhibit more pronounced resistance to iron ions as compared with cells in G1 phase, and this increase in radioresistance is diminished by RAD51 knockdown. These results implicate a role for RAD51-mediated DNA repair (i.e. HRR) in removing a fraction of clustered lesions induced by charged particle irradiation. Our results are the first to directly show the requirement for an intact HRR pathway in human cells in ensuring DNA repair and cell survival in response to high-energy high LET radiation.

Zafar, Faria; Seidler, Sara B.; Kronenberg, Amy; Schild, David; Wiese, Claudia

2010-06-29T23:59:59.000Z

4

Processing of 3'-Phosphoglycolate-Terminated DNA Double-StrandBreaks by Artemis Nuclease  

SciTech Connect (OSTI)

The Artemis nuclease is required for V(D)J recombination and for repair of an as yet undefined subset of radiation-induced DNA double-strand breaks. To assess the possibility that Artemis functions on oxidatively modified double-strand break termini, its activity toward model DNA substrates, bearing either 3{prime}-hydroxyl or 3{prime}-phosphoglycolate moieties, was examined. A 3{prime}-phosphoglycolate had little effect on Artemis-mediated trimming of long 3{prime} overhangs (>9 nucleotides), which were efficiently trimmed to 4-5 nucleotides. However, 3{prime}-phosphoglycolates on overhangs of 4-5 bases promoted selective Artemis-mediated trimming of a single 3{prime}-terminal nucleotide, while at least 2 nucleotides were trimmed from identical hydroxyl-terminated substrates. Artemis also efficiently removed a single nucleotide from a phosphoglycolate-terminated 3-base 3{prime} overhang, while leaving an analogous hydroxyl-terminated overhang largely intact. Such removal was dependent upon Ku, DNA-dependent protein kinase, and ATP. Together, these data suggest that Artemis-mediated cleavage of 3{prime} overhangs requires a minimum of 2 nucleotides, or a nucleotide plus a phosphoglycolate, 3{prime} to the cleavage site. Shorter 3{prime}-phosphoglycolate-terminated overhangs and blunt ends were also processed by Artemis, but much less efficiently. Consistent with the in vitro substrate specificity of Artemis, human cells lacking Artemis exhibited hypersensitivity to X-rays, bleomycin and neocarzinostatin, which all induce 3{prime}-phosphoglycolate-terminated double-strand breaks. Collectively, these results suggest that 3{prime}-phosphoglycolate termini and/or specific classes of DNA ends that arise from such blocked termini are relevant Artemis substrates in vivo.

Povrik, Lawrence F.; Zhou, Tong; Zhou, Ruizhe; Cowan, Morton J.; Yannone, Steven M.

2005-10-01T23:59:59.000Z

5

Telomeres and DNA double-strand breaks: ever the twain shall S. M. Baileya,* and M. N. Cornforthb  

E-Print Network [OSTI]

between the naturally occurring DNA double-strand breaks (DSBs) found at chromosome ends (i.e., telomeres Collins, CO 80523-1618 (USA), Fax: +19704917742, e-mail: sbailey@colostate.edu b Department of Radiation on their inability to rejoin with broken chromosome ends produced by radiation. Today, we recognize two essential

6

Coordinateendonucleolytic 5' and 3' trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase  

SciTech Connect (OSTI)

Previous work showed that, in the presence of DNA-PK, Artemis slowly trims 3'-phosphoglycolate-terminated blunt ends. To examine the trimming reaction in more detail, long internally labeled DNA substrates were treated with Artemis. In the absence of DNA-PK, Artemis catalyzed extensive 5' {yields} 3' exonucleolytic resection of double-stranded DNA. This resection required a 5'-phosphate but did not require ATP, and was accompanied by endonucleolytic cleavage of the resulting 3' overhang. In the presence of DNA-PK, Artemis-mediated trimming was more limited, was ATP-dependent, and did not require a 5'-phosphate. For a blunt end with either a 3'-phosphoglycolate or 3'-hydroxyl terminus, endonucleolytic trimming of 2-4 nucleotides from the 3'-terminal strand was accompanied by trimming of 6 nucleotides from the 5'-terminal strand. The results suggest that autophosphorylated DNA-PK suppresses the exonuclease activity of Artemis toward blunt-ended DNA, and promotes slow and limited endonucleolytic trimming of the 5'-terminal strand, resulting in short 3' overhangs that are trimmed endonucleolytically. Thus, Artemis and DNA-PK can convert terminally blocked DNA ends of diverse geometry and chemical structure to a form suitable for polymerase mediated patching and ligation, with minimal loss of terminal sequence. Such processing could account for the very small deletions often found at DNA double-strand break repair sites.

Povirk, Lawrence; Yannone, Steven M.; Khan, Imran S.; Zhou, Rui-Zhe; Zhou, Tong; Valerie, Kristoffer; F., Lawrence

2008-02-18T23:59:59.000Z

7

Probability of double-strand breaks in genome-sized DNA by {gamma}-ray decreases markedly as the DNA concentration increases  

SciTech Connect (OSTI)

By use of the single-molecule observation, we count the number of DNA double-strand breaks caused by {gamma}-ray irradiation with genome-sized DNA molecules (166 kbp). We find that P{sub 1}, the number of double-strand breaks (DSBs) per base pair per unit Gy, is nearly inversely proportional to the DNA concentration above a certain threshold DNA concentration. The inverse relationship implies that the total number of DSBs remains essentially constant. We give a theoretical interpretation of our experimental results in terms of attack of reactive species upon DNA molecules, indicating the significance of the characteristics of genome-sized giant DNA as semiflexible polymers for the efficiency of DSBs.

Shimobayashi, Shunsuke F. [Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606-8502 (Japan); Iwaki, Takafumi [Fukui Institute for Fundamental Chemistry, Kyoto University, Kyoto 606-8103 (Japan); Mori, Toshiaki [Radiation Research Center, Osaka Prefecture University, Sakai 599-8570 (Japan); Yoshikawa, Kenichi [Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606-8502 (Japan); Faculty of Life and Medical Sciences, Doshisha University, Kyoto 610-0394 (Japan)

2013-05-07T23:59:59.000Z

8

Induction and Rejoining of DNA Double Strand Breaks Assessed by H2AX Phosphorylation in Melanoma Cells Irradiated with Proton and Lithium Beams  

SciTech Connect (OSTI)

Purpose: The aim of this study was to evaluate the induction and rejoining of DNA double strand breaks (DSBs) in melanoma cells exposed to low and high linear energy transfer (LET) radiation. Methods and Materials: DSBs and survival were determined as a function of dose in melanoma cells (B16-F0) irradiated with monoenergetic proton and lithium beams and with a gamma source. Survival curves were obtained by clonogenic assay and fitted to the linear-quadratic model. DSBs were evaluated by the detection of phosphorylated histone H2AX ({gamma}H2AX) foci at 30 min and 6 h post-irradiation. Results: Survival curves showed the increasing effectiveness of radiation as a function of LET. {gamma}H2AX labeling showed an increase in the number of foci vs. dose for all the radiations evaluated. A decrease in the number of foci was found at 6 h post-irradiation for low LET radiation, revealing the repair capacity of DSBs. An increase in the size of {gamma}H2AX foci in cells irradiated with lithium beams was found, as compared with gamma and proton irradiations, which could be attributed to the clusters of DSBs induced by high LET radiation. Foci size increased at 6 h post-irradiation for lithium and proton irradiations in relation with persistent DSBs, showing a correlation with surviving fraction. Conclusions: Our results showed the response of B16-F0 cells to charged particle beams evaluated by the detection of {gamma}H2AX foci. We conclude that {gamma}H2AX foci size is an accurate parameter to correlate the rejoining of DSBs induced by different LET radiations and radiosensitivity.

Ibanez, Irene L. [Comision Nacional de Energia Atomica, San Martin (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Bracalente, Candelaria [Comision Nacional de Energia Atomica, San Martin (Argentina); Molinari, Beatriz L. [Comision Nacional de Energia Atomica, San Martin (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Palmieri, Monica A. [Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (Argentina); Policastro, Lucia [Comision Nacional de Energia Atomica, San Martin (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Kreiner, Andres J. [Comision Nacional de Energia Atomica, San Martin (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin (Argentina); Burlon, Alejandro A. [Comision Nacional de Energia Atomica, San Martin (Argentina); Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin (Argentina); Valda, Alejandro [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin (Argentina); Navalesi, Daniela [Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (Argentina); Davidson, Jorge; Davidson, Miguel [Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Vazquez, Monica; Ozafran, Mabel [Comision Nacional de Energia Atomica, San Martin (Argentina); Duran, Hebe [Comision Nacional de Energia Atomica, San Martin (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin (Argentina)], E-mail: hduran@cnea.gov.ar

2009-07-15T23:59:59.000Z

9

auger electron-induced double-strand: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

10

Double stranded nucleic acid biochips  

DOE Patents [OSTI]

This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector that includes a linker for immobilization on a matrix. A non-enzymatic method for synthesizing double-stranded nucleic acids with this novel connector enables the construction of inexpensive and robust dsDNA/dsRNA microarrays. DNA-DNA and DNA-protein interactions are investigated using the microarrays.

Chernov, Boris; Golova, Julia

2006-05-23T23:59:59.000Z

11

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair  

E-Print Network [OSTI]

regions of PAXX1-204 and PAXXV199A/F201A were amplified from the vectors by PCR and cloned into the pcDNA3.1(-) vector (a gift from Dr. V. Bolanos-Garcia) together with GFP or FLAG tags using In-Fusion (Clontech). Vectors were sequenced by the DNA... -treated or treated for 1 hour with 300 µM phleomycin to induce large numbers of DSBs, before being harvested either at this point or after an additional 1-hour recovery period in phleomycin-free medium after three PBS washes. Cells were washed twice in ice-cold PBS...

Ochi, Takashi; Blackford, Andrew N.; Coates, Julia; Jhujh, Satpal; Mehmood, Shahid; Tamura, Naoka; Travers, Jon; Wu, Qian; Draviam, Viji M.; Robinson, Carol V.; Blundell, Tom L.; Jackson, Stephen P.

2015-01-09T23:59:59.000Z

12

Identification, Exploitation and Manipulation of BRCA1-Dependent DNA Double-Strand Break and Interstrand Crosslink Repair in Breast and Ovarian Cancer Therapy  

E-Print Network [OSTI]

Expression of functional breast cancer susceptibility gene 1 (BRCA1) in human cancers is associated with resistance to platinum-based chemotherapeutics and poly(ADP-ribose) polymerase (PARP) inhibitors. BRCA1 is a nuclear ...

Stecklein, Shane Richard

2012-05-12T23:59:59.000Z

13

DNA Repair Alterations in Children With Pediatric Malignancies: Novel Opportunities to Identify Patients at Risk for High-Grade Toxicities  

SciTech Connect (OSTI)

Purpose: To evaluate, in a pilot study, the phosphorylated H2AX ({gamma}H2AX) foci approach for identifying patients with double-strand break (DSB) repair deficiencies, who may overreact to DNA-damaging cancer therapy. Methods and Materials: The DSB repair capacity of children with solid cancers was analyzed compared with that of age-matched control children and correlated with treatment-related normal-tissue responses (n = 47). Double-strand break repair was investigated by counting {gamma}H2AX foci in blood lymphocytes at defined time points after irradiation of blood samples. Results: Whereas all healthy control children exhibited proficient DSB repair, 3 children with tumors revealed clearly impaired DSB repair capacities, and 2 of these repair-deficient children developed life-threatening or even lethal normal-tissue toxicities. The underlying mutations affecting regulatory factors involved in DNA repair pathways were identified. Moreover, significant differences in mean DSB repair capacity were observed between children with tumors and control children, suggesting that childhood cancer is based on genetic alterations affecting DSB repair function. Conclusions: Double-strand break repair alteration in children may predispose to cancer formation and may affect children's susceptibility to normal-tissue toxicities. Phosphorylated H2AX analysis of blood samples allows one to detect DSB repair deficiencies and thus enables identification of children at risk for high-grade toxicities.

Ruebe, Claudia E., E-mail: claudia.ruebe@uks.e [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany); Fricke, Andreas; Schneider, Ruth; Simon, Karin; Kuehne, Martin; Fleckenstein, Jochen [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany); Graeber, Stefan [Institute of Medical Biometrics, Epidemiology and Medical Informatics, Saarland University, Homburg/Saar (Germany); Graf, Norbert [Department of Pediatric Hematology and Oncology, Saarland University, Homburg/Saar (Germany); Ruebe, Christian [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany)

2010-10-01T23:59:59.000Z

14

Polymerization dynamics of double-stranded biopolymers: Chemical kinetic approach  

E-Print Network [OSTI]

Polymerization dynamics of double-stranded biopolymers: Chemical kinetic approach Evgeny B 19 November 2004; accepted 20 December 2004; published online 10 March 2005 The polymerization by the processes that take place during their polymerization. However, our understanding of the coupling between

15

Spin transport and spin polarization properties in double-stranded DNA  

SciTech Connect (OSTI)

We study the spin-dependent electron transport through a double-stranded DNA (dsDNA) using the Bogoliubov-de Gennes equations and non-equilibrium Green's function method. We calculate the spin-dependent electron conductance and spin-polarization for different lengths, helix angles, twist angles of dsDNA, the environment-induced dephasing factors, and hopping integral. It is shown that the conductance decreases by increasing the length and dephasing factor. Also, we show that the spin-polarization depends on the helical symmetry and the length of DNA. It is shown that the double-stranded DNA can act as a perfect spin filter. Finally, we show that the sign of spin polarization can be inverted from +1 (?1) to ?1 (+1) for some values of hopping integral.

Simchi, Hamidreza, E-mail: simchi@iust.ac.ir [Department of Physics, Iran University of Science and Technology, Narrmak, Tehran 16844 (Iran, Islamic Republic of); Semiconductor Technology Center, Tehran (Iran, Islamic Republic of); Esmaeilzadeh, Mahdi, E-mail: mahdi@iust.ac.ir; Mazidabadi, Hossein [Department of Physics, Iran University of Science and Technology, Narrmak, Tehran 16844 (Iran, Islamic Republic of)

2013-11-21T23:59:59.000Z

16

ORIGINAL PAPER Ionizing radiation induces DNA double-strand breaks in bystander primary  

E-Print Network [OSTI]

fibroblasts Mykyta V Sokolov1,2 , Lubomir B Smilenov3 , Eric J Hall3 , Igor G Panyutin1 , William M Bonner*,4

17

Induction of linear tracks of DNA double-strand breaks by -particle irradiation of  

E-Print Network [OSTI]

eukaryotic cells by exposing the cells to particles from a small Americium source (Box 1). Each particle) EQUIPMENT Americium (Am-241) source (SupplementaryMethods and SupplementaryFigs.1­3 online) Polyester film

Cai, Long

18

A MICROBEAM STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS  

E-Print Network [OSTI]

-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of IR-induced genomic instability

19

Asymmetric quantum transport in a double-stranded Kronig-Penney model  

E-Print Network [OSTI]

We introduce a double-stranded Kronig-Penney model and analyze its transport properties. The asymmetric fluxes between two strands with suddenly alternating localization patterns are found as the energy is varied. The zero-size limit of the internal lines connecting two strands is examined using quantum graph vertices with four edges. We also consider a two-dimensional Kronig-Penney lattice with two types of alternating layers with $\\delta$ and $\\delta'$ connections, and show that the existence of energy bands in which the quantum flux can flow only in selected directions.

Taksu Cheon; Sergey S. Poghosyan

2015-03-03T23:59:59.000Z

20

Exotic quantum transport in double-stranded Kronig-Penney model  

E-Print Network [OSTI]

We introduce double-stranded Kronig-Penney model and analyze its transport properties. The asymmetric fluxes between two strands with suddenly alternating localization patterns are found as the energy is varied. The zero-size limit of the internal lines connecting two strands is examined using quantum graph vertices with four edges. We also consider a two-dimensional Kronig-Penney lattice with two types of alternating layers with $\\delta$ and $\\delta'$ connections, and show that the existence of energy bands in which the quantum flux can flow only in selected directions.

Taksu Cheon; Sergey S. Poghosyan

2014-10-31T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Site-Selective Binding of Nanoparticles to Double-Stranded DNA via Peptide Nucleic Acid "Invasion"  

SciTech Connect (OSTI)

We demonstrate a novel method for by-design placement of nano-objects along double-stranded (ds) DNA. A molecular intercalator, designed as a peptide nucleic acid (PNA)-DNA chimera, is able to invade dsDNA at the PNA-side due to the hybridization specificity between PNA and one of the duplex strands. At the same time, the single-stranded (ss) DNA tail of the chimera, allows for anchoring of nano-objects that have been functionalized with complementary ssDNA. The developed method is applied for interparticle attachment and for the fabrication of particle clusters using a dsDNA template. This method significantly broadens the molecular toolbox for constructing nanoscale systems by including the most conventional not yet utilized DNA motif, double helix DNA.

Stadler, A.L.; van der Lelie, D.; Sun, D.; Maye, M. M.; Gang, O.

2011-04-01T23:59:59.000Z

22

Proximity-induced superconductivity effect in a double-stranded DNA  

SciTech Connect (OSTI)

We study the proximity-induced superconductivity effect in a double-stranded DNA by solving the Bogoliubov-de Gennes equations and taking into account the effect of thermal fluctuations of the twist angle between neighboring base pairs. We show that the electron conductance is spin-dependent and the conductance of spin up (down) increases (decreases) due to the spin-orbit coupling (SOC). It is found that, for T?

Simchi, Hamidreza, E-mail: simchi@iust.ac.ir [Department of Physics, Iran University of Science and Technology, Narrmak, Tehran 16844 (Iran, Islamic Republic of); Semiconductor Technology Center, Tehran (Iran, Islamic Republic of); Esmaeilzadeh, Mahdi, E-mail: mahdi@iust.ac.ir; Mazidabadi, Hossein [Department of Physics, Iran University of Science and Technology, Narrmak, Tehran 16844 (Iran, Islamic Republic of)

2014-02-07T23:59:59.000Z

23

Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic ?-cells  

SciTech Connect (OSTI)

Highlights: •PKR can be activated by glucolipitoxicity and pro-inflammatory cytokines in ?-cells. •Activated PKR inhibited ?-cell proliferation by arresting cell cycle at G1 phase. •Activated PKR fully abrogated the pro-proliferative effects of IGF-I on ?-cells. -- Abstract: Double-stranded RNA-dependent protein kinase (PKR) is revealed to participate in the development of insulin resistance in peripheral tissues in type 2 diabetes (T2DM). Meanwhile, PKR is also characterized as a critical regulator of cell proliferation. To date, no study has focused on the impact of PKR on the proliferation of pancreatic ?-cells. Here, we adopted insulinoma cell lines and mice islet ?-cells to investigate: (1) the effects of glucolipotoxicity and pro-inflammatory cytokines on PKR activation; (2) the effects of PKR on proliferation of pancreatic ?-cells and its underlying mechanisms; (3) the actions of PKR on pro-proliferative effects of IGF-I and its underlying pathway. Our results provided the first evidence that PKR can be activated by glucolipitoxicity and pro-inflammatory cytokines in pancreatic ?-cells, and activated PKR significantly inhibited cell proliferation by arresting cell cycle at G1 phase. Reductions in cyclin D1 and D2 as well as increases in p27 and p53 were associated with the anti-proliferative effects of PKR, and proteasome-dependent degradation took part in the reduction of cyclin D1 and D2. Besides, PKR activation abrogated the pro-proliferative effects of IGF-I by activating JNK and disrupting IRS1/PI3K/Akt signaling pathway. These findings indicate that the anti-proliferative actions of PKR on pancreatic ?-cells may contribute to the pathogenesis of T2DM.

Chen, Shan-Shan [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China) [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China); Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing (China); Jiang, Teng [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China)] [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China); Wang, Yi; Gu, Li-Ze [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China) [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China); Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing (China); Wu, Hui-Wen [Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing (China)] [Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing (China); Tan, Lan [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China)] [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China); Guo, Jun, E-mail: Guoj@njmu.edu.cn [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China) [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China); Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing (China)

2014-01-17T23:59:59.000Z

24

Mechanistic studies of bleomycin-mediated double-stranded DNA cleavage and structural studies of DNA containing normal and 4'-oxidized abasic sites  

E-Print Network [OSTI]

In order to examine the role of partial intercalation in double-stranded (ds) DNA cleavage mediated by a single bleomycin (BLM), a bulky group ([-cyclodextrin) was chemically attached to the polyamine tail of BLM A5 to ...

Chen, Jingyang, Ph. D. Massachusetts Institute of Technology

2006-01-01T23:59:59.000Z

25

Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs  

SciTech Connect (OSTI)

Ebola virus (EBOV) protein VP35 is a double-stranded RNA (dsRNA) binding inhibitor of host interferon (IFN)-{alpha}/{beta} responses that also functions as a viral polymerase cofactor. Recent structural studies identified key features, including a central basic patch, required for VP35 dsRNA binding activity. To address the functional significance of these VP35 structural features for EBOV replication and pathogenesis, two point mutations, K319A/R322A, that abrogate VP35 dsRNA binding activity and severely impair its suppression of IFN-{alpha}/{beta} production were identified. Solution nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography reveal minimal structural perturbations in the K319A/R322A VP35 double mutant and suggest that loss of basic charge leads to altered function. Recombinant EBOVs encoding the mutant VP35 exhibit, relative to wild-type VP35 viruses, minimal growth attenuation in IFN-defective Vero cells but severe impairment in IFN-competent cells. In guinea pigs, the VP35 mutant virus revealed a complete loss of virulence. Strikingly, the VP35 mutant virus effectively immunized animals against subsequent wild-type EBOV challenge. These in vivo studies, using recombinant EBOV viruses, combined with the accompanying biochemical and structural analyses directly correlate VP35 dsRNA binding and IFN inhibition functions with viral pathogenesis. Moreover, these studies provide a framework for the development of antivirals targeting this critical EBOV virulence factor.

Prins, Kathleen C.; Delpeut, Sebastien; Leung, Daisy W.; Reynard, Olivier; Volchkova, Valentina A.; Reid, St. Patrick; Ramanan, Parameshwaran; Cárdenas, Washington B.; Amarasinghe, Gaya K.; Volchkov, Viktor E.; Basler, Christopher F. (CNRS-INSERM); (Mount Sinai Hospital); (LB-Ecuador); (Iowa State)

2010-10-11T23:59:59.000Z

26

Investigating Deinococcus radiodurans RecA Protein Filament Formation on Double-Stranded DNA by a Real-Time  

E-Print Network [OSTI]

to desiccation.2 Many hypotheses have been proposed to explain the high- efficiency repair, including a ringlike condensed chromosome structure that could restrict fragment DNA diffusion,3-5 a high Mn2+ concentration: With the aid of an efficient, precise, and almost error-free DNA repair system, Deinococcus radiodurans can

Cox, Michael M.

27

RADIATION SENSITIVITY & PROCESSING OF DNA DAMAGE FOLLOWING LOW DOSES OF GAMMA-RAY ALPHA PARTICLES & HZE IRRADIATION OF NORMAL DSB REPAIR DEFICIENT CELLS  

SciTech Connect (OSTI)

Non-homologous end joining (NHEJ) predominates in the repair of DNA double strand breaks (DSB) over homologous recombination (HR). NHEJ occurs throughout the cell cycle whereas HR occurs in late S/G2 due to the requirement of a sister chromatid (Rothkamm et al, Mol Cell Biol 23 5706-15 [2003]). To date evidence obtained with DSB repair deficient cells using pulsed-field gel electrophoresis has revealed the major pathway throughout all phases of the cell cycle for processing high dose induced DSBs is NHEJ (Wang et al, Oncogene 20 2212-24 (2001); Pluth et al, Cancer Res. 61 2649-55 [2001]). These findings however were obtained at high doses when on average >> 20-30 DSBs are formed per cell. The contribution of the repair pathways (NHEJ and HR) induced in response to DNA damage during the various phases of the cell cycle may depend upon the dose (the level of initial DSBs) especially since low levels of DSBs are induced at low dose. To date, low dose studies using NHEJ and HR deficient mutants have not been carried out to address this important question with radiations of different quality. The work presented here leads us to suggest that HR plays a relatively minor role in the repair of radiation-induced prompt DSBs. SSBs lead to the induction of DSBs which are associated specifically with S-phase cells consistent with the idea that they are formed at stalled replication forks in which HR plays a major role in repair. That DNA-PKcs is in some way involved in the repair of the precursors to replication-induced DSB remains an open question. Persistent non-DSB oxidative damage also leads to an increase in RAD51 positive DSBs. Both simple and complex non-DSB DNA damage may therefore contribute to indirect DSBs induced by ionising radiation at replication forks.

O'Neil, Peter

2009-05-15T23:59:59.000Z

28

Replication protein A and g-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks  

E-Print Network [OSTI]

pathway that removes the oxidized base lesions from the genomic DNA [6]. Evidence for the stimulation

29

The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice  

E-Print Network [OSTI]

Mitotic homologous recombination is a critical pathway for the repair of DNA double-strand breaks and broken replication forks. Although homologous recombination is generally error-free, recombination between misaligned ...

Wiktor-Brown, Dominika M

2007-01-01T23:59:59.000Z

30

GENETIC AND MOLECULAR ANALYSIS OF DNA DAMAGE REPAIR AND TOLERANCE PATHWAYS.  

SciTech Connect (OSTI)

Radiation can damage cellular components, including DNA. Organisms have developed a panoply of means of dealing with DNA damage. Some repair paths have rather narrow substrate specificity (e.g. photolyases), which act on specific pyrimidine photoproducts in a specific type (e.g., DNA) and conformation (double-stranded B conformation) of nucleic acid. Others, for example, nucleotide excision repair, deal with larger classes of damages, in this case bulky adducts in DNA. A detailed discussion of DNA repair mechanisms is beyond the scope of this article, but one can be found in the excellent book of Friedberg et al. [1] for further detail. However, some DNA damages and paths for repair of those damages important for photobiology will be outlined below as a basis for the specific examples of genetic and molecular analysis that will be presented below.

SUTHERLAND, B.M.

2001-07-26T23:59:59.000Z

31

Structure of gramicidin D-RbCl complex at atomic resolution from low-temperature synchrotron data: interactions of double-stranded gramicidin channel contents and cations with channel wall  

SciTech Connect (OSTI)

Gramicidin D (gD) is a naturally occurring ionophoric antibiotic that forms membrane channels specific for monovalent cations. The crystal structure of the RbCl complex of gD has been determined at 1.14 {angstrom} resolution from low-temperature (100 K) synchrotron-radiation data with a final R of 16%. The structure was refined with anisotropic temperature factors for all non-H atoms and with partial occupancies for many of them. The asymmetric unit in the crystal contains four crystallographically independent molecules that form two right-handed antiparallel double-stranded dimers. There are seven distinct rubidium-binding sites in each dimeric channel. The occupancy factors of Rb cations are between 0.11 and 0.35 and the total ion contents of the two crystallographically independent channels are 1.59 and 1.22 ions, respectively. Although each channel is 'chemically symmetrical', the side-chain conformations, the distributions of rubidium cations and their binding sites in the two independent channels are not. Cations are 'coordinated' by delocalized {pi}-electrons of three to five carbonyl groups that together with peptide backbone chains form the gramicidin channel walls. The water:cation ratio in the channel interior is four or five:one, and five or six waters separate Rb cations during their passage through the channel.

Glówka, M.L.; Olczak, A.; Bojarska, J.; Szczesio, M.; Duax, W.L.; Burkhart, B.M.; Pangborn, W.A.; Langs, D.A.; Wawrzak, Z. (Poland); (NWU); (Hauptman)

2010-03-05T23:59:59.000Z

32

aluminum strand coating: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov by assessing DNA double-strand break (DSB) formation in situ with the rapid and...

33

Rapid road repair vehicle  

DOE Patents [OSTI]

Disclosed is a rapid road repair vehicle capable of moving over a surface to be repaired at near normal posted traffic speeds to scan for and find an the high rate of speed, imperfections in the pavement surface, prepare the surface imperfection for repair by air pressure and vacuum cleaning, applying a correct amount of the correct patching material to effect the repair, smooth the resulting repaired surface, and catalog the location and quality of the repairs for maintenance records of the road surface. The rapid road repair vehicle can repair surface imperfections at lower cost, improved quality, at a higher rate of speed than was was heretofor possible, with significantly reduced exposure to safety and health hazards associated with this kind of road repair activities in the past.

Mara, Leo M. (Livermore, CA)

1998-01-01T23:59:59.000Z

34

Intelligent pothole repair vehicle  

E-Print Network [OSTI]

This thesis presents an endeavor to design and construct a prototype of an automated road repair vehicle called the Intelligent Pothole Repair Vehicle (IPRV). The IPRV is capable of automatically detecting and filling potholes on road surfaces...

Minocher Homji, Ruzbeh Adi

2006-10-30T23:59:59.000Z

35

Recognition of Double-Stranded RNA by Proteins  

E-Print Network [OSTI]

. Stephens Peter A. Beal University of Utah, Department of Chemistry, 315 South 1400 East, Room 2020, Salt level. In contrast, Correspondence to: Peter A. Beal; email: beal@chemistry. utah.edu). Contract grant

Beal, Peter A.

36

INTERNAL REPAIR OF PIPELINES  

SciTech Connect (OSTI)

The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. In lieu of a field installation on an abandoned pipeline, a preliminary nondestructive testing protocol is being developed to determine the success or failure of the fiber-reinforced liner pipeline repairs. Optimization and validation activities for carbon-fiber repair methods are ongoing.

Bill Bruce; Nancy Porter; George Ritter; Matt Boring; Mark Lozev; Ian Harris; Bill Mohr; Dennis Harwig; Robin Gordon; Chris Neary; Mike Sullivan

2005-07-20T23:59:59.000Z

37

INTERNAL REPAIR OF PIPELINES  

SciTech Connect (OSTI)

The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. The first round of optimization and validation activities for carbon-fiber repairs are complete. Development of a comprehensive test plan for this process is recommended for use in the field trial portion of this program.

Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

2004-12-31T23:59:59.000Z

38

INTERNAL REPAIR OF PIPELINES  

SciTech Connect (OSTI)

The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. Development of a comprehensive test plan for this process is recommended for use in the field trial portion of this program.

Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

2004-08-17T23:59:59.000Z

39

Rapid road repair vehicle  

DOE Patents [OSTI]

Disclosed are improvments to a rapid road repair vehicle comprising an improved cleaning device arrangement, two dispensing arrays for filling defects more rapidly and efficiently, an array of pre-heaters to heat the road way surface in order to help the repair material better bond to the repaired surface, a means for detecting, measuring, and computing the number, location and volume of each of the detected surface imperfection, and a computer means schema for controlling the operation of the plurality of vehicle subsystems. The improved vehicle is, therefore, better able to perform its intended function of filling surface imperfections while moving over those surfaces at near normal traffic speeds.

Mara, Leo M. (Livermore, CA)

1999-01-01T23:59:59.000Z

40

INTERNAL REPAIR OF PIPELINES  

SciTech Connect (OSTI)

The two broad categories of deposited weld metal repair and fiber-reinforced composite liner repair technologies were reviewed for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Preliminary test programs were developed for both deposited weld metal repair and for fiber-reinforced composite liner repair. Evaluation trials have been conducted using a modified fiber-reinforced composite liner provided by RolaTube and pipe sections without liners. All pipe section specimens failed in areas of simulated damage. Pipe sections containing fiber-reinforced composite liners failed at pressures marginally greater than the pipe sections without liners. The next step is to evaluate a liner material with a modulus of elasticity approximately 95% of the modulus of elasticity for steel. Preliminary welding parameters were developed for deposited weld metal repair in preparation of the receipt of Pacific Gas & Electric's internal pipeline welding repair system (that was designed specifically for 559 mm (22 in.) diameter pipe) and the receipt of 559 mm (22 in.) pipe sections from Panhandle Eastern. The next steps are to transfer welding parameters to the PG&E system and to pressure test repaired pipe sections to failure. A survey of pipeline operators was conducted to better understand the needs and performance requirements of the natural gas transmission industry regarding internal repair. Completed surveys contained the following principal conclusions: (1) Use of internal weld repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling (HDD) when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) Pipe diameter sizes range from 50.8 mm (2 in.) through 1,219.2 mm (48 in.). The most common size range for 80% to 90% of operators surveyed is 508 mm to 762 mm (20 in. to 30 in.), with 95% using 558.8 mm (22 in.) pipe. An evaluation of potential repair methods clearly indicates that the project should continue to focus on the development of a repair process involving the use of GMAW welding and on the development of a repair process involving the use of fiber-reinforced composite liners.

Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; Nancy Porter; Mike Sullivan; Chris Neary

2004-04-12T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Breaking Earth Poems  

E-Print Network [OSTI]

CALIFORNIA RIVERSIDE Breaking Earth Poems A Thesis submittedFestival……………………………………………………………………..…..14 Earth Against Mylittle else in their hands. Earth Against My Back I lay in

Hernandez, Scott Mcnaul

2012-01-01T23:59:59.000Z

42

Electric motor model repair specifications  

SciTech Connect (OSTI)

These model repair specifications list the minimum requirements for repair and overhaul of polyphase AC squireel cage induction motors. All power ranges, voltages, and speeds of squirrel cage motors are covered.

NONE

1995-08-01T23:59:59.000Z

43

Window Replacement, Rehabilitation, & Repair Guides - Building...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Window Replacement, Rehabilitation, & Repair Guides - Building America Top Innovation Window Replacement, Rehabilitation, & Repair Guides - Building America Top Innovation Effec...

44

ageing human fibroblasts: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

45

ataxia telangiectasia fibroblasts: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

46

acidic fibroblast growth: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

47

ancient human dna: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

48

adult-onset primary open-angle: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

49

angiogenic gene-modified fibroblasts: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

50

acid-induced fibroblast cell: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

51

autologous fibroblast metabolism: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

52

ancient dna studies: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

53

acid induces human: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

54

arthritis synovial fibroblasts: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

55

Modulated Tool-Path (MTP) Chip Breaking System  

SciTech Connect (OSTI)

The Modulated Tool-Path (MTP) Chip Breaking System produces user-selectable chip lengths and workpiece finishes and is compatible with any material, workpiece shape, and depth of cut. The MTP chip breaking system consistently creates the desired size of chips regardless of workpiece size, shape, or material, and the machine operator does not need to make any adjustments during the machining operation. The system's programmer configures the part program that commands the machine tool to move in a specific fashion to deliver the desired part size, shape, chip length, and workpiece surface finish. The MTP chip breaking system helps manufacturers avoid the detrimental effects of continuous chips, including expensive repair costs, delivery delays, and hazards to personnel.

Graham, K. B.

2010-04-01T23:59:59.000Z

56

Finite group symmetry breaking  

E-Print Network [OSTI]

Finite group symmetry is commonplace in Physics, in particular through crystallographic groups occurring in condensed matter physics -- but also through the inversions (C,P,T and their combinations) occurring in high energy physics and field theory. The breaking of finite groups symmetry has thus been thoroughly studied, and general approaches exist to investigate it. In Landau theory, the state of a system is described by a finite dimensional variable (the {\\it order parameter}), and physical states correspond to minima of a potential, invariant under a group. In this article we describe the basics of symmetry breaking analysis for systems described by a symmetric polynomial; in particular we discuss generic symmetry breakings, i.e. those determined by the symmetry properties themselves and independent on the details of the polynomial describing a concrete system. We also discuss how the plethora of invariant polynomials can be to some extent reduced by means of changes of coordinates, i.e. how one can reduce to consider certain types of polynomials with no loss of generality. Finally, we will give some indications on extension of this theory, i.e. on how one deals with symmetry breakings for more general groups and/or more general physical systems.

G. Gaeta

2005-10-02T23:59:59.000Z

57

Application of a Downhole Flowmeter to Detecting Casing Breaks in a Geothermal Well  

SciTech Connect (OSTI)

The downhole flowmeter logging system for high temperature geothermal wells developed at Wairakei, New Zealand, is proving to be an invaluable tool for use during workovers to repair or reinstate problem wells. This contribution describes a straightforward example of identifying breaks in plain casing near the top of a productive well.

Syms, Margot C.; Syms, Peter H.; Bixley, Paul F.

1980-12-16T23:59:59.000Z

58

SuperBreak: Using Interactivity to Enhance Ergonomic Typing Breaks  

E-Print Network [OSTI]

SuperBreak: Using Interactivity to Enhance Ergonomic Typing Breaks Dan Morris, A.J. Bernheim Brush Repetitive strain injuries and ergonomics concerns have become increasingly significant health issues software mechanisms exist for managing ergonomics; the most well-known are "break-reminder" packages

Rajamani, Sriram K.

59

Motor Repair Tech Brief  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion | Department ofT ib l L d F S i DOE TribaltheMyMinutesDepartmentCharacteristics | Motor Repair

60

$R$-Parity Breaking Phenomenology  

E-Print Network [OSTI]

We review various features of the $R$-parity breaking phenomenology, with particular attention to the low energy observables, and to the patterns of the $R$-parity breaking interactions that arise in Grand Unified models.

Francesco Vissani

1996-03-11T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Industrial motor repair in the United States  

SciTech Connect (OSTI)

This report characterizes the motor repair industry in the United States; summarizes current motor repair and testing practice; and identifies barriers to energy motor repair practice and recommends strategies for overcoming those barriers.

Schueler, V.; Leistner, P.; Douglass, J.

1994-09-01T23:59:59.000Z

62

Models of Dynamical Supersymmetry Breaking  

E-Print Network [OSTI]

We review a class of models of dynamical supersymmetry breaking, and give a unified description of these models.

Lisa Randall

1997-06-23T23:59:59.000Z

63

Large steam turbine repair: A survey  

SciTech Connect (OSTI)

This report covers a survey taken to document the current state-of-the-art in repairs to large steam turbines. One objective was to provide information to assist utilities in making repair or replacement decisions. The survey revealed that a large number of repairs have been successfully repaired involving both mechanical and welding repair techniques. Repair techniques have been improving in recent years and are being used more frequently. No guidelines or codes exist for the repair of steam turbine components so each repair is primarily controlled by agreement between the utility, contractor and insurer. Types of repairs are reviewed in this report and in addition, the capabilities of various contractors who are currently active in providing repair service. 40 refs., 10 figs., 4 tabs.

Findlan, S.J.; Lube, B. (EPRI Nondestructive Evaluation Center, Charlotte, NC (United States))

1991-07-01T23:59:59.000Z

64

Inspect and Repair Steam Traps  

SciTech Connect (OSTI)

This revised ITP tip sheet on inspecting and repairing steam traps provide how-to advice for improving industrial steam systems using low-cost, proven practices and technologies.

Not Available

2006-01-01T23:59:59.000Z

65

APPROVED Tie-Breaking Procedures  

E-Print Network [OSTI]

a public school applicant attends a low API school (1-4), or if a private school to the rest of the tie-break pool. Spring Admission Applicants recommended, relative to the rest of the tie-break pool. #12;APPROVED Denied Admission

Iglesia, Enrique

66

Automotive Repair Shops Case Study ME 4171 Automotive Repair Shops  

E-Print Network [OSTI]

shops use a wide range of equipment, chemicals, and raw materials. Available services include welding generated through welding? To repair both minor and major auto body damage, hydraulic equipment and hand are recycled with other waste oil generated on site. Question: 2) Do you expect the equipment oil

67

Verification of Motor Repair Quality  

E-Print Network [OSTI]

Motor testing at Advanced Energy has shown that a motor that has not suffered irreparable damage as a result of failure can be repaired to perform as well as before the failure. But the only way to achieve the performance level of an energy...

Butler, K.

68

Dyes designed for high sensitivity detection of double-stranded DNA  

DOE Patents [OSTI]

Novel fluorescent dyes are provided, characterized by having a fluorophore joined to a cationic chain. The dyes are found to provide for high enhancement upon binding to nucleic acid and have strong binding affinities to the nucleic acid, as compared to the fluorophore without the polycationic chain. The dyes find use in detection of dsDNA in gel electrophoresis and solution at substantially higher sensitivities using substantially less dye.

Glazer, Alexander N. (Orinda, CA); Benson, Scott C. (Oakland, CA)

1998-01-01T23:59:59.000Z

69

Dyes designed for high sensitivity detection of double-stranded DNA  

DOE Patents [OSTI]

Novel fluorescent dyes are provided, characterized by having a fluorophore joined to a polycationic chain of at least two positive charges. The dyes are found to provide for high enhancement upon binding to nucleic acid and have strong binding affinities to the nucleic acid, as compared to the fluorophore without the polycationic chain. The dyes find use in detection of dsDNA in gel electrophoresis and solution at substantially higher sensitivities using substantially less dye.

Glazer, Alexander N. (Orinda, CA); Benson, Scott C. (Albany, CA)

1994-01-01T23:59:59.000Z

70

Dyes designed for high sensitivity detection of double-stranded DNA  

DOE Patents [OSTI]

Novel fluorescent dyes are provided, characterized by having a fluorophore joined to a cationic chain. The dyes are found to provide for high enhancement upon binding to nucleic acid and have strong binding affinities to the nucleic acid, as compared to the fluorophore without the polycationic chain. The dyes find use in detection of dsDNA in gel electrophoresis and solution at substantially higher sensitivities using substantially less dye.

Glazer, Alexander N. (Orinda, CA); Benson, Scott C. (Oakland, CA)

2000-01-01T23:59:59.000Z

71

Intense photoluminescence from dried double-stranded DNA and single-walled carbon nanotube hybrid  

SciTech Connect (OSTI)

Semiconducting single-walled carbon nanotubes (SWNTs) show near-infrared photoluminescence (PL) when they are individually isolated. This was an obstacle to use photonic properties of SWNTs on a solid surface. We show that SWNTs wrapped with DNA maintain intense PL under the dry conditions. SWNTs are well isolated individually by DNA even when the DNA-SWNT hybrids are agglomerated. This finding opens up application of SWNTs to photonic devices.

Ito, M.; Kobayashi, T.; Ito, Y.; Hayashida, T.; Nii, D.; Umemura, K.; Homma, Y. [Department of Physics, Tokyo University of Science, Tokyo 162-8601 (Japan)

2014-01-27T23:59:59.000Z

72

Screening Tool for Providers of Double-Stranded DNA - Energy Innovation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administrationcontroller systemsBi (2) Sr (2)ScienceScientists In thePrincetonScottPortal

73

Chiral Symmetry Breaking in Graphene  

E-Print Network [OSTI]

The question of whether the Coulomb interaction is strong enough to break the sublattice symmetry of un-doped graphene is discussed. We formulate a strong coupling expansion where the ground state of the Coulomb Hamiltonian is found exactly and the kinetic hopping Hamiltonian is treated as a perturbation. We argue that many of the properties of the resulting system would be shared by graphene with a Hubbard model interaction. In particular, the best candidate sublattice symmetry breaking ground state is an antiferromagnetic Mott insulator. We discuss the results of some numerical simulations which indicate that the Coulomb interaction is indeed subcritical. We also point out the curious fact that, if the electron did not have spin degeneracy, the tendency to break chiral symmetry would be much greater and even relatively weak Coulomb interactions would likely gap the spectrum.

Gordon W. Semenoff

2011-08-19T23:59:59.000Z

74

Small Break Air Ingress Experiment  

SciTech Connect (OSTI)

The small break air-ingress experiment, described in this report, is designed to investigate air-ingress phenomena postulated to occur in pipes in a very high temperature gas-cooled reactor (VHTRs). During this experiment, air-ingress rates were measured for various flow and break conditions through small holes drilled into a pipe of the experimental apparatus. The holes were drilled at right angles to the pipe wall such that a direction vector drawn from the pipe centerline to the center of each hole was at right angles with respect to the pipe centerline. Thus the orientation of each hole was obtained by measuring the included angle between the direction vector of each hole with respect to a reference line anchored on the pipe centerline and pointing in the direction of the gravitational force. Using this reference system, the influence of several important parameters on the air ingress flow rate were measured including break orientation, break size, and flow velocity . The approach used to study the influence of these parameters on air ingress is based on measuring the changes in oxygen concentrations at various locations in the helium flow circulation system as a function of time using oxygen sensors (or detectors) to estimate the air-ingress rates through the holes. The test-section is constructed of a stainless steel pipe which had small holes drilled at the desired locations.

Chang Oh; Eung Soo Kim

2011-09-01T23:59:59.000Z

75

CTRLWORK AND MACBREAKZ ERGONOMIC BREAK REMINDER SOFTWARE  

E-Print Network [OSTI]

CTRLWORK AND MACBREAKZ ERGONOMIC BREAK REMINDER SOFTWARE SOFTWARE FEATURES: Analyzes your for installation assistance. 1. Please uninstall the former ergonomic break software, RSIGuard, if currently instructions on the screen. For more information, contact the UCSB Ergonomics Program at Ergonomics

California at Santa Barbara, University of

76

Role of DNA repair protein ERCC1 in skin cancer   

E-Print Network [OSTI]

Nucleotide excision repair (NER) is one of the major repair systems for removal of DNA lesions. The NER pathway has evolved mainly to repair UV-induced DNA damage and is also active against a broad range of endogenously ...

Song, Liang

2009-01-01T23:59:59.000Z

77

Automotive Repair by Number Theory Bart Snapp and Chris Snapp  

E-Print Network [OSTI]

Automotive Repair by Number Theory Bart Snapp and Chris Snapp While repairing the ignition switch on a 1981 Fiat Spider, we discovered the following connection between number theory and automotive repair

Snapp, Bart

78

The feasibility of electrophoretic repair of impoundment leaks  

E-Print Network [OSTI]

finding, repairing and testing the leaks, are tedious, expensive, and dangerous to workers. Electrophoretic repair technique is an innovative, economic, and safe method to repair the leakage of impoundments. A suspension of clay particles is induced...

Han, Ji-Seok

2002-01-01T23:59:59.000Z

79

Repair of overheating linear accelerator  

SciTech Connect (OSTI)

Los Alamos Neutron Science Center (LANSCE) is a proton accelerator that produces high energy particle beams for experiments. These beams include neutrons and protons for diverse uses including radiography, isotope production, small feature study, lattice vibrations and material science. The Drift Tube Linear Accelerator (DTL) is the first portion of a half mile long linear section of accelerator that raises the beam energy from 750 keV to 100 MeV. In its 31st year of operation (2003), the DTL experienced serious issues. The first problem was the inability to maintain resonant frequency at full power. The second problem was increased occurrences of over-temperature failure of cooling hoses. These shortcomings led to an investigation during the 2003 yearly preventative maintenance shutdown that showed evidence of excessive heating: discolored interior tank walls and coper oxide deposition in the cooling circuits. Since overheating was suspected to be caused by compromised heat transfer, improving that was the focus of the repair effort. Investigations revealed copper oxide flow inhibition and iron oxide scale build up. Acid cleaning was implemented with careful attention to protection of the base metal, selection of components to clean and minimization of exposure times. The effort has been very successful in bringing the accelerator through a complete eight month run cycle allowing an incredible array of scientific experiments to be completed this year (2003-2004). This paper will describe the systems, investigation analysis, repair, return to production and conclusion.

Barkley, Walter; Baldwin, William; Bennett, Gloria; Bitteker, Leo; Borden, Michael; Casados, Jeff; Fitzgerald, Daniel; Gorman, Fred; Johnson, Kenneth; Kurennoy, Sergey; Martinez, Alberto; O’Hara, James; Perez, Edward; Roller, Brandon; Rybarcyk, Lawrence; Stark, Peter; Stockton, Jerry

2004-01-01T23:59:59.000Z

80

INTERNAL REPAIR OF PIPELINES REVIEW & EVALUATION OF INTERNAL PIPELINE REPAIR TRIALS REPORT  

SciTech Connect (OSTI)

The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is generally ineffective at restoring the pressure containing capabilities of pipelines. Failure pressure for pipe repaired with carbon fiber-reinforced composite liner was greater than that of the un-repaired pipe section with damage, indicating that this type of liner is effective at restoring the pressure containing capability of pipe. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. Development of a comprehensive test plan for this process is recommended for use in the next phase of this project.

Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

2004-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Cadmium sulfate and CdTe-quantum dots alter DNA repair in zebrafish (Danio rerio) liver cells  

SciTech Connect (OSTI)

Increasing use of quantum dots (QDs) makes it necessary to evaluate their toxicological impacts on aquatic organisms, since their contamination of surface water is inevitable. This study compares the genotoxic effects of ionic Cd versus CdTe nanocrystals in zebrafish hepatocytes. After 24 h of CdSO{sub 4} or CdTe QD exposure, zebrafish liver (ZFL) cells showed a decreased number of viable cells, an accumulation of Cd, an increased formation of reactive oxygen species (ROS), and an induction of DNA strand breaks. Measured levels of stress defense and DNA repair genes were elevated in both cases. However, removal of bulky DNA adducts by nucleotide excision repair (NER) was inhibited with CdSO{sub 4} but not with CdTe QDs. The adverse effects caused by acute exposure of CdTe QDs might be mediated through differing mechanisms than those resulting from ionic cadmium toxicity, and studying the effects of metallic components may be not enough to explain QD toxicities in aquatic organisms. - Highlights: • Both CdSO{sub 4} and CdTe QDs lead to cell death and Cd accumulation. • Both CdSO{sub 4} and CdTe QDs induce cellular ROS generation and DNA strand breaks. • Both CdSO{sub 4} and CdTe QDs induce the expressions of stress defense and DNA repair genes. • NER repair capacity was inhibited with CdSO{sub 4} but not with CdTe QDs.

Tang, Song; Cai, Qingsong [The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79416 (United States); Chibli, Hicham [Department of Biomedical Engineering, McGill University, Montréal, QC H3A 2B4 (Canada); Allagadda, Vinay [The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79416 (United States); Nadeau, Jay L. [Department of Biomedical Engineering, McGill University, Montréal, QC H3A 2B4 (Canada); Mayer, Gregory D., E-mail: greg.mayer@ttu.edu [The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79416 (United States)

2013-10-15T23:59:59.000Z

82

Electric vehicle repairs and modifications  

SciTech Connect (OSTI)

This informal report describes the electric vehicle (EV) inspection and the necessary maintenance and repairs required to improve reliable operation of five Volkswagen (VW) Electrotransporter vans and five VW EV buses. The recommendations of TVA, EPRI, GES, Volkswagen, Siemens, and Hoppecke have been carried out in this effort. These modifications were necessary before entering the EPRI/TVA phase II and III continuing program. As new energy storage systems are explored using the VW test-bed vehicles in the battery field testing program, additional modifications may be required. All modifications will be submitted to the vehicle and component manufacturer for general assessment and recommendations. At present three different types of battery systems are being evaluated in six VW vehicles. The two Hoppecke and Exide utilize the modified Hoppecke charging systems. The other batteries being tested require off-board chargers specified by their manufacturer and are separate from the vehicle system.

Buffett, R.K.

1982-11-01T23:59:59.000Z

83

Breaking down the bubbly | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone6 M.ExtracellularBradbury Science MuseumBrainBreaking a

84

DNA purification by triplex-affinity capture and affinity capture electrophoresis  

DOE Patents [OSTI]

The invention provides a method for purifying or isolating double stranded DNA intact using triple helix formation. The method includes the steps of complexing an oligonucleotide and double stranded DNA to generate a triple helix and immobilization of the triple helix on a solid phase by means of a molecular recognition system such as avidin/biotin. The purified DNA is then recovered intact by treating the solid phase with a reagent that breaks the bonds between the oligonucleotide and the intact double stranded DNA while not affecting the Watson-Crick base pairs of the double helix. The present invention also provides a method for purifying or isolating double stranded DNA intact by complexing the double stranded DNA with a specific binding partner and recovering the complex during electrophoresis by immobilizing it on a solid phase trap imbedded in an electrophoretic gel. 6 figs.

Cantor, C.R.; Ito, Takashi; Smith, C.L.

1996-01-09T23:59:59.000Z

85

Analysis of cell cycle surveillance mechanisms in meiosis  

E-Print Network [OSTI]

Numerous DNA double-strand breaks (DSBs) are introduced into the genome in the course of meiotic recombination. This poses a significant hazard to the genomic integrity of the cell. Studies in a number of organisms have ...

Hochwagen, Andreas

2006-01-01T23:59:59.000Z

86

CATASTROPHIC REPAIR REQUEST CHECKLIST Office of Research  

E-Print Network [OSTI]

Not Meet Policy Not Sure Equipment may not be covered by a service contract that provides for repair Contacted: ______________ Amount of Annual Service Contract: $ ___________ Meets Policy Info Pending Does

Schladow, S. Geoffrey

87

Vehicle Repair Policy Outline the policy regarding vehicle repair on University of Michigan (U-M) vehicles.  

E-Print Network [OSTI]

Vehicle Repair Policy Objective Outline the policy regarding vehicle repair on University of Michigan (U-M) vehicles. Policy 1. All vehicle repairs performed on U-M vehicles must be coordinated facility to repair their fleet vehicles. 2. U-M vehicles leased through Fleet Services include routine

Kirschner, Denise

88

Issues in standard model symmetry breaking  

SciTech Connect (OSTI)

This work discusses the symmetry breaking sector of the SU(2) x U(1) electroweak model. The first two chapters discuss Higgs masses in two simple Higgs models. The author proves low-enery theorems for the symmetry breaking sector: The threshold behavior of gauge-boson scattering is completely determined, whenever the symmetry breaking sector meets certain simple conditions. The author uses these theorems to derive event rates for the superconducting super collider (SSC). The author shows that the SSC may be able to determine whether the interactions of the symmetry breaking sector are strong or weak. 54 refs.

Golden, M.

1988-04-01T23:59:59.000Z

89

Electroweak Symmetry Breaking via QCD  

E-Print Network [OSTI]

We propose a new mechanism to generate the electroweak scale within the framework of QCD, which is extended to include conformally invariant scalar degrees of freedom belonging to a larger irreducible representation of $SU(3)_c$. The electroweak symmetry breaking is triggered dynamically via the Higgs portal by the condensation of the colored scalar field around 1 TeV. The mass of the colored boson is restricted to be 350 GeV $\\lesssim m_S\\lesssim $ 3 TeV, with the upper bound obtained from perturbative renormalization group evolution. This implies that the colored boson can be produced at LHC. If the colored boson is electrically charged, the branching fraction of the Higgs decaying into two photons can slightly increase, and moreover, it can be produced at future linear colliders. Our idea of non-perturbative EW scale generation can serve as a new starting point for more realistic model building in solving the hierarchy problem.

Jisuke Kubo; Kher Sham Lim; Manfred Lindner

2014-09-01T23:59:59.000Z

90

Degeneracy Breaking of Hydrogen Atom  

E-Print Network [OSTI]

The three dimensional rotation group, SO(3), is a symmetry group of the normal hydrogen atom. Each reducible representation of this group can be associated with a degenerate energy level. If this atom is placed in an external magnetic field, the interaction between the orbital magnetic moment with this field will lead to a symmetry breaking where the symmetry group of the atom is a new group distinct from the SO(3) group. This phenomenon describes the normal Zeeman effect, where a degenerate energy level splits into several new energy levels. It is explicitly shown that each of the new energy levels can be associated with an irreducible representation of the new symmetry group.

Agung Trisetyarso; Pantur Silaban

2014-11-21T23:59:59.000Z

91

Alan Turing as a Statistician: Breaking the Code by Breaking the Bayesian Egg  

E-Print Network [OSTI]

Alan Turing as a Statistician: Breaking the Code by Breaking the Bayesian Egg Joseph K. Blitzstein, Harvard University Alan Turing is widely considered the father of computer science. Yet even

Wolfe, Patrick J.

92

Vanadium catalysts break down biomass for fuels  

E-Print Network [OSTI]

- 1 - Vanadium catalysts break down biomass for fuels March 26, 2012 Vanadium catalysts break down biomass into useful components Due to diminishing petroleum reserves, non-food biomass (lignocellulose biomass into high-value commodity chemicals. The journal Angewandte Chemie International Edition published

93

Gauge symmetry breaking in orbifold model building  

E-Print Network [OSTI]

We review the gauge symmetry breaking mechanism due to orbifold projections in orbifold model building. We explicitly show the existence of a scale of breaking if such a symmetry breaking is due to freely-acting orbifold operators only, i.e. in case the breaking is realized non-locally in the internal space. We show that such a scale is related to the compactification moduli only, and that there are no extra continuous parameters, at least in semirealistic models with N=1 SUSY in four dimensions. In this sense, the mechanism is peculiarly different from the standard Higgs (or Hosotani) symmetry breaking mechanism. We show that the mechanism also differs from that present in standard orbifold models where, even in presence of discrete Wilson lines, a scale of breaking is generically missing, since the breaking is localized in specific points in the internal space. We review a set of background geometries where the described non-local breaking is realized, both in the case of two and six extra dimensions. In the latter case, relevant in string model building, we consider both heterotic and open string compactifications.

Michele Trapletti

2006-11-02T23:59:59.000Z

94

E-Print Network 3.0 - annular repair strategies Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

- lowing a user to create custom repair strategies. ReAssert used a five-step repair process around its... library of repair ... Source: Marinov, Darko - Department of...

95

Fabrication Flaws in Reactor Pressure Vessel Repair Welds  

SciTech Connect (OSTI)

This paper describes the fabrication flaw distribution and characterization in the repair weld metal of reactor pressure vessels. This work indicates that the large flaws occur in these repairs. These results show that repair flaws are complex in composition and sometimes include cracks on the repair ends. Parametric analysis using an exponential fit is performed on the data. A description of repair flaw morphology is provided. Fabrication flaws in repairs are characterized using high sensitivity nondestructive ultrasonic testing, validation by other nondestructive evaluation (NDE) techniques, and complemented by destructive testing.

Schuster, George J.; Doctor, Steven R.

2007-12-01T23:59:59.000Z

96

Explicit versus Spontaneous Diffeomorphism Breaking in Gravity  

E-Print Network [OSTI]

Gravitational theories with fixed background fields break local Lorentz and diffeomorphism invariance either explicitly or spontaneously. In the case of explicit breaking it is known that conflicts can arise between the dynamics and geometrical constraints, while spontaneous breaking evades this problem. It is for this reason that in the gravity sector of the Standard-Model Extension (SME) it is assumed that the background fields (SME coefficients) originate from spontaneous symmetry breaking. However, in other examples, such as Chern-Simons gravity and massive gravity, diffeomorphism invariance is explicitly broken by the background fields, and the potential conflicts between the dynamics and geometry can be avoided in most cases. An analysis of how this occurs is given, and the conditions that are placed on the metric tensor and gravitational structure as a result of the presence of an explicit-breaking background are described. The gravity sector of the SME is then considered for the case of explicit breaking. However, it is found that a useful post-Newtonian limit is only obtained when the symmetry breaking is spontaneous.

Robert Bluhm

2015-04-02T23:59:59.000Z

97

Repairable chip bonding/interconnect process  

DOE Patents [OSTI]

A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder.

Bernhardt, Anthony F. (Berkeley, CA); Contolini, Robert J. (Livermore, CA); Malba, Vincent (Livermore, CA); Riddle, Robert A. (Tracy, CA)

1997-01-01T23:59:59.000Z

98

Repairable chip bonding/interconnect process  

DOE Patents [OSTI]

A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules is disclosed. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder. 10 figs.

Bernhardt, A.F.; Contolini, R.J.; Malba, V.; Riddle, R.A.

1997-08-05T23:59:59.000Z

99

Development of a composite repair system for reinforcing offshore risers  

E-Print Network [OSTI]

A research program was conducted to investigate the application of composite materials in repairing corroded offshore risers, leading to the development of an optimized repair using a hybrid carbon/E-glass system. The objective of this research...

Alexander, Christopher Richard

2009-05-15T23:59:59.000Z

100

Phonemic Categorization and Phonotactic Repair as Parallel Sublexical Processes   

E-Print Network [OSTI]

categorization and phonotactic repair are sublexical and simultaneous; phonotactic repairs themselves depend on coarticulation cues. Such models can be implemented in two different versions: suprasegmental matching, according to which a speech signal is matched...

Ishikawa, Kiyoshi

2014-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Airborne observations of the kinematics and statistics of breaking waves  

E-Print Network [OSTI]

v 3 Observations of wave breaking kinematics in fetch-crest length . . . . . C.6 Wave elevation . . . . . . . .breaking waves in the images . . . . . . . . . . . 3.3.3

Kleiss, Jessica M.

2009-01-01T23:59:59.000Z

102

Break-out Discussion i: Modeling Consumer Behavior Residential...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Break-out Discussion i: Modeling Consumer Behavior Residential Scale Break-out Discussion i: Modeling Consumer Behavior Residential Scale This presentaion summarizes the...

103

Breaking Parity Symmetry Using Extra Dimensions  

E-Print Network [OSTI]

We present a new way to break parity symmetry in left-right symmetric models using boundary conditions on the fields residing in the fifth dimension. We also discuss the connection between the limits on the size of extra dimensions and the scale of right handed symmetry breaking obtained from the analysis of neutrinoless double beta decay in the case where the righthanded gauge symmetry is in the bulk.

R. N. Mohapatra; A. Pérez-Lorenzana

1999-11-17T23:59:59.000Z

104

Repairable File and Storage Systems A Dissertation Presented  

E-Print Network [OSTI]

Repairable File and Storage Systems A Dissertation Presented by Ningning Zhu to The Graduate School of the Dissertation Repairable File and Storage System by Ningning Zhu Doctor of Philosophy in Computer Science Stony stream file/storage system. Repairable file/storage system needs to perform two tasks. First it has

Chiueh, Tzi-cker

105

Visualization of Mismatch Repair in Bacterial Cells  

E-Print Network [OSTI]

We determined the localizations of mismatch repair proteins in living Bacillus subtilis cells. MutS-GFP colocalized with the chromosome in all cells and formed foci in a subset of cells. MutL-GFP formed foci in a subset ...

Smith, Bradley T.

106

Method for mask repair using defect compensation  

DOE Patents [OSTI]

A method for repair of amplitude and/or phase defects in lithographic masks. The method involves modifying or altering a portion of the absorber pattern on the surface of the mask blank proximate to the mask defect to compensate for the local disturbance (amplitude or phase) of the optical field due to the defect.

Sweeney, Donald W. (San Ramon, CA); Ray-Chaudhuri, Avijit K. (Livermore, CA)

2001-01-01T23:59:59.000Z

107

EPA Lead Safety for Renovation, Repair and  

E-Print Network [OSTI]

than 20 f lead-based paint is dis- e exterior. Window replace- onsidered minor mainte- air. If you're of thousands of dollars in fines and put yourself and your company at risk of po- tential lawsuits. 2. ProtectEPA Lead Safety for Renovation, Repair and Painting (RRP) Course Certified Renovators Class

Tennessee, University of

108

Repairing Type Errors in Functional Programs   

E-Print Network [OSTI]

Type systems for programming languages can be used by compilers to reject programs which are found to be unsound and which may, therefore, fail to execute successfully. When a program is rejected the programmer must repair it so that it can be type...

McAdam, Bruce J

109

An emergency response team for membrane repair  

E-Print Network [OSTI]

events, which we focus on here. As discussed later, Ca2+ influx at the site of plasma membrane-fusion events are required to repair a torn plasma membrane, and we propose that this emergency products and the plasma membrane. Reseal or die. Plasma-membrane disruption is a normal event in the life

Kirchhausen, Tomas

110

Laboratory testing of closure cap repair techniques  

SciTech Connect (OSTI)

Landfill design requires a low permeability closure cap as well as a low permeability liner. The Savannah River Site, in South Carolina, has approximately 85 acres of mixed waste landfills covered with compacted kaolin clay. Maintaining low permeability of the clay cap requires both that the permeability of the compacted clay itself remain low and that the integrity of the barrier be maintained. Barrier breaches typically result from penetration by roots or animals, and especially cracks caused by uneven settling or desiccation. In this study, clay layers, 0.81 m in diameter and 7.6 cm thick, were compacted in 7 lysimeters to simulate closure caps. The hydraulic conductivity of each layer was measured, and the compacted clay layers (CCL`s) were cracked by drying. Then various repair techniques were applied and the effectiveness of each repair was assessed by remeasuring the hydraulic conductivity. Finally the repaired CCL was again dried and measured to determine how the repair responded to the conditions that caused the original failure. For a full report of this investigation see Persoff et al. Six repair techniques have been tested, four of which involve the use of injectable barrier liquids colloidal silica (CS) and polysiloxane (PSX) described below: (I) covering the crack with a bentonite geosynthetic clay liner (GCL), (ii) recompaction of new kaolinite at STD+3 moisture content joined to existing kaolinite that had dried and shrunk, (iii) direct injection of colloidal silica to a crack, (iv) injection of colloidal silica (CS) to wells in an overlying sand layer, (v) direct injection of polysiloxane to a crack, and (vi), injection of polysiloxane (PSX) to wells in an overlying soil layer.

Persoff, P.; Moridis, G. [Lawrence Berkeley National Lab., CA (United States); Tuck, D.M. [Westinghouse Savannah River Company, Aiken, SC (United States)] [and others

1996-10-01T23:59:59.000Z

111

New Mechanisms of Gauge-Mediated Supersymmetry Breaking  

E-Print Network [OSTI]

We review the motivation for Gauge-Mediated Supersymmetry Breaking and discuss some recent advances.

Lisa Randall

1997-06-23T23:59:59.000Z

112

Laboratory Directed Research and Development Program. Annual report  

SciTech Connect (OSTI)

This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

Ogeka, G.J.; Romano, A.J.

1992-12-01T23:59:59.000Z

113

Laboratory Directed Research and Development Program  

SciTech Connect (OSTI)

This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

Ogeka, G.J.; Romano, A.J.

1992-12-01T23:59:59.000Z

114

Double-strand DNA-templated formation of copper nanoparticles as fluorescent probe for label free nuclease enzyme detection  

E-Print Network [OSTI]

cleavage activity. Thus, a label-free strategy for sensitive detection of nuclease has been developed B.V. All rights reserved. 1. Introduction As promising substitutes for organic dyes and quantum dots epithelial cervical cancer cells (HeLa cells) using fluorescent gold nanoparticles which emitted a stable

Tan, Weihong

115

Chimera Death: Symmetry Breaking in Dynamical Networks  

E-Print Network [OSTI]

For a network of generic oscillators with nonlocal topology and symmetry-breaking coupling we establish novel partially coherent inhomogeneous spatial patterns, which combine the features of chimera states (coexisting incongruous coherent and incoherent domains) and oscillation death (oscillation suppression), which we call chimera death. We show that due to the interplay of nonlocality and breaking of rotational symmetry by the coupling two distinct scenarios from oscillatory behavior to a stationary state regime are possible: a transition from an amplitude chimera to chimera death via in-phase synchronized oscillations, and a direct abrupt transition for larger coupling strength.

Anna Zakharova; Marie Kapeller; Eckehard Schöll

2014-02-03T23:59:59.000Z

116

Symmetry-Breaking Constraints for Matrix Models  

E-Print Network [OSTI]

-breaking constraints. Experimental re- sults confirm their value. 1 Introduction Symmetry in a CSP model is an important issue as the exploration of symmet- ric but essentially equivalent branches in a search tree may techniques have been developed to address the issue of eliminating symmetry in CSP models. An important class

Flener, Pierre

117

REPLACE YOUR MERCURY THERMOMETERS BEFORE THEY BREAK!  

E-Print Network [OSTI]

REPLACE YOUR MERCURY THERMOMETERS BEFORE THEY BREAK! Did you know, mercury from broken thermometers to the local environment, if broken thermometers in sinks eventually end at the sanitary sewer plant. Broken mercury thermometers create hazardous waste that is costly to clean up and costly to dispose of. Other

118

Motor Repair Tech Brief | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Year in3.pdfEnergy HealthCommentsAugust 2012 Monthly ProjectEnterprisesRepair Tech Brief Motor

119

Winter Break 2011 (January) Knowledge is Power Program  

E-Print Network [OSTI]

, TX) · Kentucky Equine Humane Center (Nicholsville, Kentucky) · Grand Canyon: Kane Ranch (Marble participants) · Community Collaborations, Flood Relief (Atlanta, GA) (10 participants) Weekend Breaks Fall 2009, San Juan, TX (10 participants) Weekend Break Fall 2008 (October)-12 participants · Cedar Rapids

120

Reddit AMA: Marius Stan, energy researcher and Breaking Bad actor...  

Broader source: Energy.gov (indexed) [DOE]

Reddit AMA: Marius Stan, energy researcher and Breaking Bad actor Reddit AMA: Marius Stan, energy researcher and Breaking Bad actor February 14, 2013 - 12:36pm Addthis Marius Stan,...

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Wind Power Reliability: Breaking Down a Barrier | Department...  

Broader source: Energy.gov (indexed) [DOE]

Wind Power Reliability: Breaking Down a Barrier Wind Power Reliability: Breaking Down a Barrier June 25, 2010 - 12:16pm Addthis EnerNex Corporation is developing documentation and...

122

Housing and Dining Services Spring Break Information March 2011  

E-Print Network [OSTI]

charge to stay over spring break. Kitchenettes will be open in all residence halls over the break period equipment · Refrigerators with food may be left on · Close and lock your windows and doors · Turn off your

123

Laboratory Studies of Nonlinear and Breaking Surface Waves  

E-Print Network [OSTI]

A. Breaking-wave generation . . . . . . . . . . . . . . . .of the wave tank. . . . . . . . . . . . . . . . . . . .On steep gravity waves meeting a vertical wall: a triple

Drazen, David

2006-01-01T23:59:59.000Z

124

Gravity dual of metastable dynamical supersymmetry breaking  

SciTech Connect (OSTI)

Metastable, supersymmetry-breaking configurations can be created in flux geometries by placing antibranes in warped throats. Via gauge/gravity duality, such configurations should have an interpretation as supersymmetry-breaking states in the dual field theory. In this paper, we perturbatively determine the asymptotic supergravity solutions corresponding to D3-brane probes placed at the tip of the cascading warped deformed conifold geometry, which is dual to an SU(N+M)xSU(N) gauge theory. The backreaction of the antibranes has the effect of introducing imaginary anti-self-dual flux, squashing the compact part of the space and forcing the dilaton to run. Using the generalization of holographic renormalization to cascading geometries, we determine the expectation values of operators in the dual field theory in terms of the asymptotic values of the supergravity fields.

DeWolfe, Oliver [Department of Physics, 390 UCB, University of Colorado, Boulder, Colorado 80309 (United States); Kachru, Shamit; Mulligan, Michael [Department of Physics and SLAC, Stanford University, Stanford, California 94305/94309 (United States)

2008-03-15T23:59:59.000Z

125

Comparison of protein patterns of xrs-5, a radiosensitive Chinese hamster ovary cell line, and CHO-K1, its radioresistant parent, using two-dimensional gel-electrophoresis  

SciTech Connect (OSTI)

X-ray sensitive strains of Chinese hamster ovary cell lines have been used to analyze radiation repair mechanisms. One cell line, xrs-5, has been shown to be very sensitive to ionizing radiation and radical forming chemical mutagens. This sensitivity is thought to be a result a mutation in the DNA double strand break (DSB) repair mechanism, and its characterization has been a goal of several repair mechanism studies. Using two-dimensional gel electrophoresis, we have detected a protein (MW approximately 55KD) in the DNA/Nuclear Matrix (nucleoid) cell fraction of CHO-Kl cells that is absent in the nucleoid fraction of xrs-5. This protein is present, however, in both CHO-Kl and xrs-5 whole cell protein maps. To determine whether the 55KD protein is responsible for the radiosensitive and defective DSB repair phenotype of xrs-5 cells, studies are now underway to analyze revertants of xrs-5 that are proficient in DSB repair. Furthermore, an effort to sequence the protein in question is planned. 23 refs., 2 figs.

Kramer, J.M. (Miami Univ., Oxford, OH (USA). Dept. of Zoology)

1991-01-01T23:59:59.000Z

126

Textural break foundation wall construction modules  

DOE Patents [OSTI]

Below-grade, textural-break foundation wall structures are provided for inhibiting diffusion and advection of liquids and gases into and out from a surrounding hydrogeologic environment. The foundation wall structure includes a foundation wall having an interior and exterior surface and a porous medium disposed around a portion of the exterior surface. The structure further includes a modular barrier disposed around a portion of the porous medium. The modular barrier is substantially removable from the hydrogeologic environment.

Phillips, Steven J. (Kennewick, WA)

1990-01-01T23:59:59.000Z

127

Dec. 13-Jan. 3 Winter Break  

E-Print Network [OSTI]

Dec. 13-Jan. 3 Winter Break Students must be out of residence halls by 10 a.m. on Dec. 13. Students may return to residence halls after 1 p.m. on Jan. 3. Jan. 8 Last day to drop a course without a fee Dance Company Grupo de Rua 8 p.m., Campbell Hall Arts & Lectures tickets may be purchased by calling

California at Santa Barbara, University of

128

Charge breaking bounds in the Zee model  

E-Print Network [OSTI]

We study the possibility that charge breaking minima occur in the Zee model. We reach very different conclusions from those attained in simpler, two Higgs doublet models, and the reason for this is traced back to the existence of cubic terms in the potential. A scan of the Zee model's parameter space shows that CB is restricted to a narrow region of values of the parameters.

A. Barroso; P. M. Ferreira

2005-10-11T23:59:59.000Z

129

Proceedings of design, repair, and refurbishment of steam turbines  

SciTech Connect (OSTI)

This book reports on the proceedings of design, repair and refurbishment of steam engines. Topics covered include: Advisor/Expert Systems for Steam Turbines; Moisture Effects on the Operating and Performance of Steam Turbines; Turbine Steam Path Development; Repair and Refurbishment of the Electric Generator Components; and Advanced Steam Turbine Designs.

Warnock, A.S. (Lehigh Univ., PA (United States))

1991-01-01T23:59:59.000Z

130

Improved Criteria for the Repair of Fabrication Flaws  

SciTech Connect (OSTI)

Section III of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code for nuclear power plant components requires radiographic examinations (RT) of welds and requires repairs for RT indications that exceed code acceptable sizes. This paper describes research that has generated data on welding flaws, which indicated that the largest flaws occur in repaired welds. The fabrication flaws were detected in material removed from cancelled nuclear power plants using high sensitivity Nondestructive Examination (NDE) and validated by complementary NDE and destructive testing. Evidence suggests that repairs are often for small and benign RT indications at locations buried within the vessel or pipe wall. Probabilistic fracture mechanics calculations are described in this paper to predict the increases in vessel and piping failure probabilities caused by the repair-induced flaws. Calculations address failures of embrittled vessel welds for pressurized thermal shock (PTS) transients and piping failures caused by fatigue crack growth. For vessels the small flaws, which are relatively common, can cause brittle fracture, such that the rarely encountered repair flaws of large sizes gave only modestly increased failure probabilities. Calculations for piping show that only relatively large fabrication flaws can cause failures because of the ductile nature of the piping material. The large repair flaws therefore significantly increased the failure probabilities. The paper recommends the use of more discriminating ultrasonic examinations in place of RT examinations along with repair criteria based on a fitness-for-purpose approach that minimize the number of unjustified repairs.

Doctor, Steven R.; Schuster, George J.; Simonen, Fredric A.

2004-12-01T23:59:59.000Z

131

Quality electric motor repair: A guidebook for electric utilities  

SciTech Connect (OSTI)

This guidebook provides utilities with a resource for better understanding and developing their roles in relation to electric motor repair shops and the industrial and commercial utility customers that use them. The guidebook includes information and tools that utilities can use to raise the quality of electric motor repair practices in their service territories.

Schueler, V.; Douglass, J.

1995-08-01T23:59:59.000Z

132

E-Print Network 3.0 - anaemia-dna repair connection Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Barclay Morrison and his Neurotrauma and Repair Laboratory... yet unknown, this repair process is aborted. If Morrison can find ... Source: Hone, James - Center for Electron...

133

Spontaneous Supersymmetry Breaking Induced by Vacuum Condensates  

E-Print Network [OSTI]

We propose a novel mechanism of spontaneous supersymmetry breaking which relies upon an ubiquitous feature of Quantum Field Theory, vacuum condensates. Such condensates play a crucial r\\^{o}le in many phenomena. Examples include Unruh effect, superconductors, particle mixing, and quantum dissipative systems. We argue that in all these phenomena supersymmetry, when present, is spontaneously broken. Evidence for our conjecture is given for the Wess--Zumino model, that can be considered an approximation to the supersymmetric extensions of the above mentioned systems. The magnitude of the effect is estimated for a recently proposed experimental setup based on an optical lattice.

Antonio Capolupo; Marco Di Mauro

2012-08-29T23:59:59.000Z

134

Cloud Properties Working Group Break Out Session  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed New SubstationClean Communities of WesternVailCloisteredPresence of AerosolsBreak

135

Exploring Cartan gravity with dynamical symmetry breaking  

E-Print Network [OSTI]

It has been known for some time that General Relativity can be regarded as a Yang-Mills-type gauge theory in a symmetry broken phase. In this picture the gravity sector is described by an $SO(1,4)$ or $SO(2,3)$ gauge field $A^{a}_{\\phantom{a}b\\mu}$ and Higgs field $V^{a}$ which acts to break the symmetry down to that of the Lorentz group $SO(1,3)$. This symmetry breaking mirrors that of electroweak theory. However, a notable difference is that while the Higgs field $\\Phi$ of electroweak theory is taken as a genuine dynamical field satisfying a Klein-Gordon equation, the gauge independent norm $V^2\\equiv \\eta_{ab}V^{a}V^{b}$ of the Higgs-type field $V^a$ is typically regarded as non-dynamical. Instead, in many treatments $V^a$ does not appear explicitly in the formalism or is required to satisfy $V^2 = \\mathrm{const.} \

H. F. Westman; T. G. Zlosnik

2014-03-24T23:59:59.000Z

136

Chip breaking system for automated machine tool  

DOE Patents [OSTI]

The invention is a rotary selectively directional valve assembly for use in an automated turret lathe for directing a stream of high pressure liquid machining coolant to the interface of a machine tool and workpiece for breaking up ribbon-shaped chips during the formation thereof so as to inhibit scratching or other marring of the machined surfaces by these ribbon-shaped chips. The valve assembly is provided by a manifold arrangement having a plurality of circumferentially spaced apart ports each coupled to a machine tool. The manifold is rotatable with the turret when the turret is positioned for alignment of a machine tool in a machining relationship with the workpiece. The manifold is connected to a non-rotational header having a single passageway therethrough which conveys the high pressure coolant to only the port in the manifold which is in registry with the tool disposed in a working relationship with the workpiece. To position the machine tools the turret is rotated and one of the tools is placed in a material-removing relationship of the workpiece. The passageway in the header and one of the ports in the manifold arrangement are then automatically aligned to supply the machining coolant to the machine tool workpiece interface for breaking up of the chips as well as cooling the tool and workpiece during the machining operation.

Arehart, Theodore A. (Clinton, TN); Carey, Donald O. (Oak Ridge, TN)

1987-01-01T23:59:59.000Z

137

1Ottawa 7/05 Structural Break DetectionStructural Break Detection  

E-Print Network [OSTI]

://www.stat.colostate.edu/~rdavis/lectures) This research supported in part by an IBM faculty award. #12;2Ottawa 7/05 Introduction Setup Examples AR GARCH for structural break estimation Simulation results Applications Simulation results for GARCH and SSM #12;3Ottawa/05 Examples (cont) 2. Segmented GARCH model: where 0 = 1

138

'Jet breaks' and 'missing breaks' in the X-Ray afterglow of Gamma Ray Bursts  

E-Print Network [OSTI]

The X-ray afterglows (AGs) of Gamma-Ray Bursts (GRBs) and X-Ray Flashes (XRFs) have, after the fast decline phase of their prompt emission, a temporal behaviour varying between two extremes. A large fraction of these AGs has a 'canonical' light curve which, after an initial shallow-decay 'plateau' phase, 'breaks smoothly' into a fast power-law decline. Very energetic GRBs, contrariwise, appear not to have a 'break', their AG declines like a power-law from the start of the observations. Breaks and 'missing breaks' are intimately related to the geometry and deceleration of the jets responsible for GRBs. In the frame of the 'cannonball' (CB) model of GRBs and XRFs, we analyze the cited extreme behaviours (canonical and pure power-law) and intermediate cases spanning the observed range of X-ray AG shapes. We show that the entire panoply of X-ray light-curve shapes --measured with Swift and other satellites-- are as anticipated, on very limpid grounds, by the CB model. We test the expected correlations between the...

Dado, Shlomo; De Rújula, Alvaro

2008-01-01T23:59:59.000Z

139

Intermediate hearth repair technique at Thyssen Stahl AG  

SciTech Connect (OSTI)

Nowadays various techniques for the fastest possible intermediate repair and/or emplacement of refractory materials above the tuyere level allow a significant extension of furnace campaign life. The latter are hence now exclusively determined by the service life of the hearth. The improvement of hearth monitoring and the estimation of residual brick strength of the refractory lining on the basis of temperature measurements in the hearth enable the location of individual zones of premature wear. These measurement methods, which were developed by Thyssen Stahl AG, aid the decision to undertake selective repair of the hearth. Three areas of repair are differentiated: taphole zone; hearth wall, localized; and hearth wall, extensive. This hearth repair method is described in this report using the example of hearth refurbishing blast furnace 8, Hamborn.

Kowalski, W.; Bachhofen, H.J.; Ruether, P.; Ballewski, T. [Thyssen Stahl AG, Duisburg (Germany)

1996-12-31T23:59:59.000Z

140

Microsoft Word - SPR Emergency Pipeline Repair, 2013-2017 NEPA...  

Broader source: Energy.gov (indexed) [DOE]

Exclusion to be applied: B5.4 Repair or replacement of sections of a crude oil, produced water, brine or geothermal pipeline, if the actions are determined by the Army...

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Incremental temporal reasoning in job shop scheduling repair  

E-Print Network [OSTI]

A working predictive schedule can be useless because of the various external or internal disruptions in a job shop. Total rescheduling may cause problems such as shop floor nervousness. Thus, the job shop scheduling repair ...

Huang, Y.

142

A tissue engineering strategy for integrative cartilage repair  

E-Print Network [OSTI]

Tissue engineering for cartilage repair is a promising approach for improving the healing of articular defects, as biomaterials and growth factors can be supplied directly to a focal lesion. However, integrating neo-tissue ...

Mroszczyk, Keri A

2014-01-01T23:59:59.000Z

143

LANL breaks ground on key sediment control project  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sediment control project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately 2 million features are up to eight feet high and...

144

Understanding the Electroweak Symmetry Breaking: The Higgs Boson...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Understanding the Electroweak Symmetry Breaking: The Higgs Boson and Beyond (Monday, March 2) DATE: Monday, March 2, 4:10 pm LOCATION: Physics 0003 Understanding the Electroweak...

145

Symmetry Breaking in Graphene Gregory S. Boebinger, National...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Symmetry Breaking in Graphene Gregory S. Boebinger, National High Magnetic Field Laboratory DMR-Award 0654118 DC Field Facility While the laws of physics are often symmetric,...

146

Isospin-Breaking quark condensates in Chiral Perturbation Theory  

E-Print Network [OSTI]

We analyze the isospin-breaking corrections to quark condensates within one-loop SU(2) and SU(3) Chiral Perturbation Theory including $m_u\

A. Gomez Nicola; R. Torres Andres

2011-11-14T23:59:59.000Z

147

Dynamical electroweak symmetry breaking and the top quark  

SciTech Connect (OSTI)

In this talk, I discuss theories of dynamical electroweak symmetry breaking, with emphasis on the implications of a heavy top quark on the weak interaction {rho} parameter.

Chivukula, R.S. [Boston Univ., MA (United States)

1997-01-01T23:59:59.000Z

148

Coherent testing and simulation of composite blade repair  

E-Print Network [OSTI]

COHERENT TESTING AND SIMULATION OF COMPOSITE BLADE REPAIR A Thesis by BRIAN GLENN MCNICHOLS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE... December 1997 Major Subject: Mechanical Engineering COHERENT TESTING AND SIMULATION OF COMPOSITE BLADE REPAIR A Thesis by BRIAN GLENN MCNICHOLS Submitted to Texas A&M University In partial fulfillment of the requirements for the degree of MASTER...

McNichols, Brian Glenn

2012-06-07T23:59:59.000Z

149

December 8, 2011 FRONTIER HALL WINTER BREAK CLOSING INFORMATION  

E-Print Network [OSTI]

December 8, 2011 FRONTIER HALL WINTER BREAK CLOSING INFORMATION Frontier Hall will officially close directly before you leave. After 8pm you will no longer be able to access Frontier Hall. Please keep will need during this time. We cannot let you back into Frontier once we have closed for break. If you

Janssen, Michel

150

Resonant Instability in Mountain Waves: Breaking at Subcritical Mountain Heights  

E-Print Network [OSTI]

Resonant Instability in Mountain Waves: Breaking at Subcritical Mountain Heights Kevin Viner1 and breaks subcritical critical Nh/U = 0.5 Nh/U = 0.8 #12;Subcritical Instability: An Example three peaks · Nh/U = 0.6 · U/NL = 0.1 · nonrotating · Time-dependent model initialized with subcritical steady wave

151

1SCRA 2006 FIM XIII-PORTUGAL Structural Break Detection for a ClassStructural Break Detection for a Class  

E-Print Network [OSTI]

1000 -4-202 Any breaks in this series? #12;5SCRA 2006 FIM XIII-PORTUGAL Introduction Examples AR GARCH for structural break estimation Simulation results Applications Simulation results for GARCH and SV models #12 (cont) 2. Segmented GARCH model: where 0 = 1

152

1NCAR-IMAGe 2006 Structural Break Detection in Time Series ModelsStructural Break Detection in Time Series Models  

E-Print Network [OSTI]

-202 Any breaks in this series? #12;5NCAR-IMAGe 2006 Introduction Examples AR GARCH Stochastic volatility break estimation Simulation results Applications Simulation results for GARCH and SV models #12;6NCAR-tjptjptjjt tYYY jj GARCH model

153

Creaming and breaking of liquid emulsions: a free boundary problem 1 / 48 Creaming and breaking of liquid  

E-Print Network [OSTI]

, as opposite to the other case called instead a water-in-oil emulsion. #12;Creaming and breaking of liquid emulsions: a free boundary problem 4 / 48 What is an emulsion? Everyday life examples (a) water-in-oil of the model 5 A priori estimates 6 Existence and uniqueness #12;Creaming and breaking of liquid emulsions

Rosso, Fabio

154

Polymer nanocomposites for high-temperature composite repair  

SciTech Connect (OSTI)

A novel repair agent for resin-injection repair of advanced high temperature composites was developed and characterized. The repair agent was based on bisphenol E cyanate ester (BECy) and reinforced with alumina nanoparticles. To ensure good dispersion and compatibility with the BECy matrix in nanocomposites, the alumina nanoparticles were functionalized with silanes. The BECy nanocomposites, containing bare and functionalized alumina nanoparticles, were prepared and evaluated for their thermal, mechanical, rheological, and viscoelastic properties. The monomer of BECy has an extremely low viscosity at ambient temperature, which is good for processability. The cured BECy polymer is a highly cross-linked network with excellent thermal mechanical properties, with a high glass transition temperature (T{sub g}) of 270 C and decomposition temperature above 350 C. The incorporation of alumina nanoparticles enhances the mechanical and rheological properties of the BECy nanocomposites. Additionally, the alumina nanoparticles are shown to catalyze the cure of BECy. Characterization of the nanocomposites included dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy. The experimental results show that the BECy nanocomposite is a good candidate as repair agent for resin-injection repair applications.

Sheng, Xia

2008-12-01T23:59:59.000Z

155

Charge symmetry breaking in $\\Lambda$ hypernuclei revisited  

E-Print Network [OSTI]

The large charge symmetry breaking (CSB) implied by the $\\Lambda$ binding energy difference $\\Delta B^{4}_{\\Lambda}(0^+_{\\rm g.s.})\\equiv B_{\\Lambda}(_{\\Lambda}^4$He)$-$$B_{\\Lambda}(_{\\Lambda}^4$H) = 0.35$\\pm$0.06 MeV of the $A=4$ mirror hypernuclei ground states, determined from emulsion studies, has defied theoretical attempts to reproduce it in terms of CSB in hyperon masses and in hyperon-nucleon interactions, including one pion exchange arising from $\\Lambda-\\Sigma^0$ mixing. Using a schematic strong-interaction $\\Lambda N\\leftrightarrow\\Sigma N$ coupling model developed by Akaishi and collaborators for $s$-shell $\\Lambda$ hypernuclei, we revisit the evaluation of CSB in the $A=4$ $\\Lambda$ hypernuclei and extend it to $p$-shell mirror $\\Lambda$ hypernuclei. The model yields values of $\\Delta B^{4}_{\\Lambda} (0^+_{\\rm g.s.})\\sim 0.25$ MeV. Smaller size and mostly negative $p$-shell binding energy differences are calculated for the $A=7-10$ mirror hypernuclei, in rough agreement with the few available dat...

Gal, Avraham

2015-01-01T23:59:59.000Z

156

Nuclear apoJ: A low dose radiation inducible regulator of cell death. Final report for period September 15, 1998 - September 14, 2001  

SciTech Connect (OSTI)

This project was based on preliminary data that was published by Dr. Boothman (Yang et al. 2000) which indicated a strong induction of apoJ gene expression, increased secretion of the protein, and accumulation of an apparently somewhat different form of the apoJ protein in the nucleus of MCF-7 breast carcinoma cells undergoing response to DNA damage. A clone expressing apoJ protein was isolated that was capable of interacting with Ku80, a component of the double strand break repair complex that is essential for the successful repair of rearranging immunoglobulin and T-cell receptor genes as evidenced by failure to produce mature B and T cells in the absence of Ku70. ApoJ clones isolated and characterized by Dr. Boothman bound strongly to a Ku-70 ''bait'' protein. Over-expression of these same clones in a cell line was capable of killing the cell. ApoJ is very strongly induced in many instances of programmed cell death and has been proposed repeatedly to play some sort of effector role in the process. Our principle hypothesis for this study was that the strong induction of the apoJ gene and the particular expression of a nuclear form of the protein was potentially a causal factor in the decision point made by the cell as it attempts to repair double-strand breakage based DNA damage. The hypothesis was that if sufficiently high damage occurred, it would be deleterious to maintain the cell's viability through continued DNA repair. One method to inhibit DNA repair might be by inhibiting proteins such as Ku-70 that are necessary for double-strand break repair. If apoJ does play a critical role in tipping the decision balance over to cell death, we reasoned that deficiency of apoJ would cause increased accumulation of cells with DNA damage and that this might decrease cell death in response to DNA damage and increase tumor occurrence rates. To test this hypothesis and its potential implications, we exposed wildtype and apoJ deficient animals that we constructed through gene targeting to increasing levels of ionizing radiation from a Cesium source. Data gathered under the support of this grant application initially indicated that apoJ deficient animals were more resistant to radiation, but as we accumulated more and more data points and covered a tighter exposure range, the genotype-based differences became insignificant. However, the possibility existed that because mortality based radiation-resistance could be attributable to mechanism for which nuclear apoJ was not rate determining, we maintained a very large of colony of apoJ knockout and wildtype animals in both the C57/B16 and Cv129 strain backgrounds that were exposed to sub-lethal levels of ionizing radiation to monitor for the occurrence of tumors. These animals were allowed to fully recover and age normally in either germ free or normal animal housing. Our results demonstrated no significant differences between wildtype and apoJ knockout animals over a period that extended up to 30 months for individual animals. We recorded similar weight gain, a relatively low mortality rate, and a similar mixture and rate of sarcoma and adenocarcinomas after surviving the initial ionizing radiation exposures. Thus we conclude that apoJ gene function, which was totally eliminated by our gene targeting, did not influence radiation sensitivity or serve as a tumor suppressor in response to DNA damage.

Aronow, Bruce J.

2002-04-19T23:59:59.000Z

157

Development of criteria for fatigue repairs in bridge girders damaged by out-of-plane distortion  

E-Print Network [OSTI]

repaired and unrepaired cracks along the longitudinal web-to-flange connection of a plate girder subjected to a linear bending stress to determine if repair by drilling holes is really necessary. The results of the finite element analyses...

Wilson, Scott David

1994-01-01T23:59:59.000Z

158

Wave breaking along the stratospheric polar vortex as seen in ERA-40 data  

E-Print Network [OSTI]

1983), Breaking planetary waves in the stratosphere, Nature,structure of breaking Rossby waves in the polar wintertimecontrol of upward wave flux near the tropopause, Geophys.

Abatzoglou, John T; Magnusdottir, Gudrun

2007-01-01T23:59:59.000Z

159

SciTech Connect: Sphericity and symmetry breaking in the formation...  

Office of Scientific and Technical Information (OSTI)

and symmetry breaking in the formation of FrankKasper phases from one component materials Citation Details In-Document Search Title: Sphericity and symmetry breaking in the...

160

Novel Thermal Break with Simplified Manufacturing for R7 Commercial...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

(R5 OptiQ-Ultra Thermal Windows). Windows incorporating the foam-based sandwich-type thermal-break would achieve U-Factor of 0.14 Btuhr-ft2-F (R7 or better) with...

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

New Mechanisms of Gauge-Mediated Supersymmetry Breaking  

E-Print Network [OSTI]

We introduce new mechanisms for the communication of supersymmetry breaking via gauge interactions. These models do not require complicated dynamics to induce a nonvanishing F term for a singlet. The first class of models communicates supersymmetry breaking to the visible sector through a ``mediator" field that transforms under both a messenger gauge group of the dynamical supersymmetry breaking sector and the standard model gauge group. This model has distinctive phenomenology; in particular, the scalar superpartners should be heavier by at least an order of magnitude than the gaugino superpartners. The second class of models has phenomenology more similar to the ``standard" messenger sectors. A singlet is incorporated, but the model does not require complicated mechanisms to generate a singlet F term. The role of the singlet is to couple fields from the dynamical symmetry breaking sector to fields transforming under the standard model gauge group. We also mention a potential solution to the $\\mu$ problem.

Lisa Randall

1996-12-19T23:59:59.000Z

162

Synchronous Symmetry Breaking in Neurons with Different Neurite Counts  

E-Print Network [OSTI]

As neurons develop, several immature processes (i.e., neurites) grow out of the cell body. Over time, each neuron breaks symmetry when only one of its neurites grows much longer than the rest, becoming an axon. This symmetry ...

Wissner-Gross, Zachary D.

163

Tackling Epistemological Problems (TEP) A didactical engineering to break through  

E-Print Network [OSTI]

Tackling Epistemological Problems (TEP) A didactical engineering to break through the amazing world, becomes a didactical obstacle for the learning of this geometry. We need to use 3D models and also dynamic

Spagnolo, Filippo

164

Sets of Symmetry Breaking Constraints Barbara M. Smith  

E-Print Network [OSTI]

Sets of Symmetry Breaking Constraints Barbara M. Smith Cork Constraint Computation Centre, University College Cork, Ireland b.m.smith@4c.ucc.ie Abstract [Puget, 2004] has shown that if the symmetry

Smith, Barbara M.

165

Development of quick repairing technique for ceramic burner in hot stove of blast furnace  

SciTech Connect (OSTI)

Refractories of ceramic burner in hot stoves at Wakayama No. 4 blast furnace were damaged. There are only three hot stoves, so repairing must be done in a short. Therefore, a quick repairing technique for ceramic burners has been developed, and two ceramic burners were repaired in just 48 hours.

Kondo, Atsushi; Doura, Kouji; Nakamura, Hirofumi [Sumitomo Metal Industries, Ltd., Wakayama (Japan). Wakayama Steel Works

1997-12-31T23:59:59.000Z

166

DNA Repair 8 (2009) 803812 Contents lists available at ScienceDirect  

E-Print Network [OSTI]

reduced gap repair and loss of the checkpoint response to low-dose irradiation. These findings shed light. Loss of the FHA domain resulted in hypersensitivity to ionizing radiation and defects in gap repair time for repair pro- cesses to act. A given DNA damage response protein may be involved Corresponding

Sekelsky, Jeff

167

Workshop Proceedings: Life Assessment and Repair of Steam Turbine Casings  

SciTech Connect (OSTI)

With the trend toward operating steam turbines far beyond their design lives, utilities need methods for assessing and extending the lives of the turbine casings. Consolidating and publishing industry experience on this subject will help utilities make run/replace decisions, select appropriate repair techniques, implement operational changes, and select new designs to meet future needs.

None

1986-07-01T23:59:59.000Z

168

Corrosion Repair and Corrosion Protection of Reinforced Concrete Structures in  

E-Print Network [OSTI]

11/14/2014 1 Corrosion Repair and Corrosion Protection of Reinforced Concrete Structures in Pulp and Paper Mills Vector Construction / Vector Corrosion Technologies www.vectorgroup.com www.vector-corrosion.com Presentation Outline · Introduction · Corrosion of Reinforced Concrete Structures · Protection of Chests

Das, Suman

169

Thermosetting Polymer-Matrix Composites for Strucutral Repair Applications  

SciTech Connect (OSTI)

Several classes of thermosetting polymer matrix composites were evaluated for use in structural repair applications. Initial work involved the characterization and evaluation of woven carbon fiber/epoxy matrix composites for structural pipeline repair. Cyanate ester resins were evaluated as a replacement for epoxy in composites for high-temperature pipe repair applications, and as the basis for adhesives for resin infusion repair of high-temperature composite materials. Carbon fiber/cyanate ester matrix composites and fumed silica/cyanate ester nanocomposites were evaluated for their thermal, mechanical, viscoelastic, and rheological properties as they relate to their structure, chemistry, and processing characteristics. The bisphenol E cyanate ester under investigation possesses a high glass transition temperature, excellent mechanical properties, and unique ambient temperature processability. The incorporate of fumed silica served to enhance the mechanical and rheological properties of the polymer and reduce thermal expansion without sacrificing glass transition or drastically altering curing kinetics. Characterization of the composites included dynamic mechanical analysis, thermomechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy.

William Kirby Goertzen

2007-12-01T23:59:59.000Z

170

USDA Grants to Help Repair Housing in Rural Areas  

Broader source: Energy.gov [DOE]

The U.S. Department of Agriculture (USDA) is accepting applications for the Housing Preservation Grant program, which provides funding to repair low-income housing, rental properties, or co-op owned housing. Eligible sponsors include state agencies, local government, Tribes, and nonprofits.

171

HOW TO REPAIR A SECOND-ORDER SURFACE FOR COMPUTER  

E-Print Network [OSTI]

1 HOW TO REPAIR A SECOND-ORDER SURFACE FOR COMPUTER EXPERIMENTS BY KRIGING Astrid JOURDAN and analysis of computer experiments have been widely investigated in the past decade. Two approaches seem describes and compares them briefly in order to present a methodology for computer experiments based

Paris-Sud XI, Université de

172

Development/Plasticity/Repair Group I Metabotropic Glutamate Receptors Control  

E-Print Network [OSTI]

Development/Plasticity/Repair Group I Metabotropic Glutamate Receptors Control Metaplasticity the spinal cord can support several forms of plasticity, including response­outcome (instrumental) learning. This inhibi- tion of plasticity in spinal learning is itself a form of plasticity that requires i

Grau, James

173

Breakthrough Technologies In Vivo Observation of Cavitation and Embolism Repair  

E-Print Network [OSTI]

Breakthrough Technologies In Vivo Observation of Cavitation and Embolism Repair Using Magnetic that approximately 10 vessels had cavitated during this time. Leaf water potentials decreased from 1.25 to 2.1 MPa cavitation. Refilling of xylem vessels occurred as soon as the lights were switched off, with the majority

Holbrook, N. Michele

174

Development/Plasticity/Repair Identification of Nicotinic Acetylcholine Receptor Recycling  

E-Print Network [OSTI]

Development/Plasticity/Repair Identification of Nicotinic Acetylcholine Receptor Recycling and Its, University of Michigan, Ann Arbor, Michigan 48109 In the CNS, receptor recycling is critical for synaptic plasticity; however, the recycling of receptors has never been observed at peripheral synapses. Using a novel

Alford, Simon

175

Complications of Endovascular Repair of Abdominal Aortic Aneurysms: A Review  

SciTech Connect (OSTI)

The endovascular procedure for repair of abdominal aortic aneurysms has had an enormous impact on the treatment of this challenging disease. Complications, however, do occur and it is important to have a thorough understanding of the array of complications and appropriate management strategies. In this review of endovascular complications, we describe early and late complications paying particular attention to preventive, treatment and surveillance strategies.

Katzen, Barry T. [Baptist Cardiac and Vascular Institute, Baptist Health Systems, Department of Interventional Radiology, Florida (United States)], E-mail: barryk@baptisthealth.net; MacLean, Alexandra A. [New York Hospital-Queens, Department of Surgery (United States)

2006-12-15T23:59:59.000Z

176

1Kaiserslautern 9/05 Structural Break Detection in Time Series ModelsStructural Break Detection in Time Series Models  

E-Print Network [OSTI]

Regressive Modeling 4 pieces, 2.58 seconds. #12;4Kaiserslautern 9/05 Introduction Examples AR GARCH Stochastic for structural break estimation Simulation results Applications Simulation results for GARCH and SSM #12. Segmented GARCH model: where 0 = 1

177

Gel and process for preventing carbon dioxide break through  

SciTech Connect (OSTI)

A process is described for retarding the flow of carbon dioxide in carbon dioxide break-through fingers in a subterranean formation, the process comprising: (a) introducing a gas selected from the group consisting of carbon dioxide and gases containing carbon dioxide into a subterranean deposit containing carbon dioxide break-through fingers; (b) after the carbon dioxide break-through fingers have sorbed a predetermined amount of the gas, stopping the flow of the gas into the subterranean formation, (c) after stopping the flow of the gas into the subterranean formation, introducing an effective amount of a gel-forming composition into the subterranean formation and into the carbon dioxide break-through fingers, the gel-forming composition being operable, when contacting carbon dioxide break-through fingers containing the brine which has absorbed substantial amounts of carbon dioxide to form a gel in the fingers which is operable for retarding the flow of the gas in the finger. The gel-forming composition comprises: i. an aqueous solution comprising a first substance selected from the group consisting of polyvinyl alcohols, polyvinyl alcohol copolymers, and mixtures thereof, and ii. an amount of a second substance selected from the group consisting of aldehydes, aldehyde generating substances, acetals, acetal generating substances, and mixtures thereof.

Sandiford, B.B.; Zillmer, R.C.

1987-06-16T23:59:59.000Z

178

Combined Haploinsufficiency for ATM and RAD9 as a Factor in Cell Transformation, Apoptosis, and DNA Lesion Repair Dynamics  

E-Print Network [OSTI]

Lesion Repair Dynamics Lubomir B. Smilenov, Howard B. Lieberman, Stephen A. Mitchell, Ronald A. Baker

179

Breaking anchored droplets in a microfluidic Hele-Shaw cell  

E-Print Network [OSTI]

We study microfluidic self digitization in Hele-Shaw cells using pancake droplets anchored to surface tension traps. We show that above a critical flow rate, large anchored droplets break up to form two daughter droplets, one of which remains in the anchor. Below the critical flow velocity for breakup the shape of the anchored drop is given by an elastica equation that depends on the capillary number of the outer fluid. As the velocity crosses the critical value, the equation stops admitting a solution that satisfies the boundary conditions; the drop breaks up in spite of the neck still having finite width. A similar breaking event also takes place between the holes of an array of anchors, which we use to produce a 2D array of stationary drops in situ.

Amselem, Gabriel; Gallaire, François; Baroud, Charles N

2015-01-01T23:59:59.000Z

180

Application of break preclusion concept in German nuclear power plants  

SciTech Connect (OSTI)

The break preclusion concept is based on {open_quotes}KTA rules{close_quotes}, {open_quotes}RSK guidelines{close_quotes} and {open_quotes}Rahmenspeziflkation Basissicherheit{close_quotes}. These fundamental rules containing for example requirements on material, design, calculation, manufacturing and testing procedures are explained and the technical realisation is shown by means of examples. The proof of the quality of these piping systems can be executed by means of fracture mechanics calculations by showing that in every case the leakage monitoring system already detect cracks which are clearly smaller than the critical crack. Thus the leak before break behavior and the break preclusion concept is implicitly affirmed. In order to further diminish conservativities in the fracture mechanics procedures, specific research projects are executed which are explained in this contribution.

Roos, E. [Energie-Versorgung Schwaben AG, Stuttgart (Germany); Maier, V. [Bayernwerk AG, Muenchen (Germany); Nagel, G. [PraussenElektra AG, Hannover (Germany)] [and others

1997-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Lorentz symmetry breaking as a quantum field theory regulator  

SciTech Connect (OSTI)

Perturbative expansions of quantum field theories typically lead to ultraviolet (short-distance) divergences requiring regularization and renormalization. Many different regularization techniques have been developed over the years, but most regularizations require severe mutilation of the logical foundations of the theory. In contrast, breaking Lorentz invariance, while it is certainly a radical step, at least does not damage the logical foundations of the theory. I shall explore the features of a Lorentz symmetry breaking regulator in a simple polynomial scalar field theory and discuss its implications. In particular, I shall quantify just 'how much' Lorentz symmetry breaking is required to fully regulate the quantum theory and render it finite. This scalar field theory provides a simple way of understanding many of the key features of Horava's recent article [Phys. Rev. D 79, 084008 (2009)] on 3+1 dimensional quantum gravity.

Visser, Matt [School of Mathematics, Statistics, and Operations Research, Victoria University of Wellington, Wellington 6140 (New Zealand)

2009-07-15T23:59:59.000Z

182

Charge Symmetry Breaking and Parity Violating Electron-Proton Scattering  

E-Print Network [OSTI]

Charge symmetry breaking contributions to the proton's neutral weak form factors must be understood in order for future measurements of parity violating electron-proton scattering to be definitively interpreted as evidence of proton strangeness. We calculate these charge symmetry breaking form factor contributions using chiral perturbation theory with resonance saturation estimates for unknown low-energy constants. The uncertainty of the leading-order resonance saturation estimates is reduced by incorporating nuclear physics constraints. Higher-order contributions are investigated through phenomenological vertex form factors. We predict that charge symmetry breaking form factor contributions are an order of magnitude larger than expected from naive dimensional analysis but are still an order of magnitude smaller than current experimental bounds on proton strangeness. This is consistent with previous calculations using chiral perturbation theory with resonance saturation.

Michael Wagman; Gerald A. Miller

2014-12-16T23:59:59.000Z

183

Comparing Measured Fluorocarbon Leader Breaking Strength with Manufacturer Claims  

E-Print Network [OSTI]

The experiment reported in this article addresses manufacturer claims of fluorocarbon leader material strength versus experimental tests of leaders strength. Breaking strength of fishing line is the most common specification when marketing fishing line. In this study, eight leaders rated near 15 pounds by their manufacturers were tested. Each leader was tested with a knot in the line and without a knot in the line. The strongest leader tested without a knot was Cabela's Seaguar fluorocarbon and the weakest leader tested without a knot was Cabela's Premier leader. The highest strength of leaders with a knot was the Ande Monofilament Fluorocarbon and the lowest breaking strength of leaders with a knot was the Seaguar Grand Max Fluorocarbon. Few published studies actually test the breaking strength of a leader to determine the accuracy of manufacturers' claims. Tensile strengths are also reported.

Haight, Christine; McQueeney, Kathleen; Courtney, Ya'el

2012-01-01T23:59:59.000Z

184

Mutation Research 684 (2010) 8189 Contents lists available at ScienceDirect  

E-Print Network [OSTI]

irradiation DNA double strand breaks Nitric oxide Cell proliferation a b s t r a c t Low-dose -particle irradiated by low-dose -particles (1­10 cGy) in a mixed system. Further studies indicated that nitric oxide exposures comprise 55% of the environmental dose to the human population and have been shown to induce

Yu, K.N.

185

Biomolecular Simulation of Base Excision Repair and Protein Signaling  

SciTech Connect (OSTI)

The goal of the Biomolecular Simulation of Base Excision Repair and Protein Signaling project is to enhance our understanding of the mechanism of human polymerase-?, one of the key enzymes in base excision repair (BER) and the cell-signaling enzymes cyclic-AMP-dependent protein kinase. This work used molecular modeling and simulation studies to specifically focus on the • dynamics of DNA and damaged DNA • dynamics and energetics of base flipping in DNA • mechanism and fidelity of nucleotide insertion by BER enzyme human polymerase-? • mechanism and inhibitor design for cyclic-AMP-dependent protein kinase. Molecular dynamics simulations and electronic structure calculations have been performed using the computer resources at the Molecular Science Computing Facility at the Environmental Molecular Sciences Laboratory.

Straatsma, TP; McCammon, J. A.; Miller, John H.; Smith, Paul E.; Vorpagel, Erich R.; Wong, Chung F.; Zacharias, Martin W.

2006-03-03T23:59:59.000Z

186

Providing protection: Agencies receive funding to repair, upgrade dams  

E-Print Network [OSTI]

Story by Kathy Wythe tx H2O | pg. 26 Providing protection Agencies receive funding to repair, upgrade dams along with local partners, can apply for grant funds, he said. Construction of the dams began through four federal authorizations... totaling about $11 million. Of the 343 dams currently classified as high hazard, Scattered across Texas are almost 2,000 nondescript, earthen dams built on private land to protect property, roads, and bridges from flood damages. Some of these dams...

Wythe, Kathy

2009-01-01T23:59:59.000Z

187

Cis, Isotactic Selective ROMP of Norbornenes Fused with N-Arylpyrrolidines. Double Stranded Polynorbornene-Based Ladderphanes with Z-Double Bonds  

E-Print Network [OSTI]

Upon treatment with a molybdenum-carbene with bidentate substituted biaryl-o,o?-diphenoxide ligand 12, norbornene fused with N-aryl-endo-pyrrolidine 9a undergoes ROMP to give exclusively polynorbornene with cis, ...

Zhu, Lei

188

Monosporascus root rot/vine decline: a study of double-stranded (DS) RNA and its role in the pathogenesis of Monosporascus cannonballus on muskmelon  

E-Print Network [OSTI]

dodecyl sulfate (SDS), and 10 mg of carborundum (Sigma Chemical Co. , St. Louis, MO) for 1 min and incubated for 30 min at 37'C to allow for degradation of host RNAs. Nucleic acids were extracted with an equal volume of TE saturated phenol...

Batten, Jeffrey Samuel

1997-01-01T23:59:59.000Z

189

Margins in high temperature leak-before-break assessments  

SciTech Connect (OSTI)

Developments in the defect assessment procedure R6 to include high-temperature mechanisms in Leak-before-Break arguments are described. In particular, the effect of creep on the time available to detect a leak and on the crack opening area, and hence leak rate, is discussed. The competing influence of these two effects is emphasized by an example. The application to Leak-before-Break of the time-dependent failure assessment diagram approach for high temperature defect assessment is then outlined. The approach is shown to be of use in assessing the erosion of margins by creep.

Budden, P.J.; Hooton, D.G.

1997-04-01T23:59:59.000Z

190

Charge and CP symmetry breaking in two Higgs doublet models  

E-Print Network [OSTI]

We show that, for the most generic model with two Higgs doublets possessing a minimum that preserves the $U(1)_{em}$ symmetry, charge breaking (CB) cannot occur. If CB does not occur, the potential could have two different minima, and there is in principle no general argument to show which one is the deepest. The depth of the potential at a stationary point that breaks CB or CP, relative to the $U(1)_{em}$ preserving minimum, is proportional to the squared mass of the charged or pseudoscalar Higgs, respectively.

A. Barroso; P. M. Ferreira; R. Santos

2005-11-07T23:59:59.000Z

191

Breaking the Fuel Cell Cost Barrier | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartmentTie Ltd: ScopeDepartment1, DOE/SC-0095 Breakng theBreaking the Fuel

192

Enhancement of the RAD51 Recombinase Activity by the Tumor Suppressor PALB2  

SciTech Connect (OSTI)

Homologous recombination mediated by the RAD51 recombinase helps eliminate chromosomal lesions, such as DNA double-stranded breaks induced by radiation or arising from injured DNA replication forks. The tumor suppressors BRCA2 and PALB2 act together to deliver RAD51 to chromosomal lesions to initiate repair. Here we document a new function of PALB2 in the enhancement of RAD51's ability to form the D-loop. We show that PALB2 binds DNA and physically interacts with RAD51. Importantly, while PALB2 alone stimulates D-loop formation, a cooperative effect is seen with RAD51AP1, an enhancer of RAD51. This stimulation stems from PALB2's ability to function with RAD51 and RAD51AP1 to assemble the synaptic complex. Our results help unveil a multi-faceted role of PALB2 in chromosome damage repair. Since PALB2 mutations can cause breast and other tumors or lead to Fanconi anemia, our findings are important for understanding the mechanism of tumor suppression in humans.

Dray, Eloise; Etchin, Julia; Wiese, Claudia; Saro, Dorina; Williams, Gareth J.; Hammel, Michal; Yu, Xiong; Galkin, Vitold E.; Liu, Dongqing; Tsai, Miaw-Sheue; Sy, Shirley M-H.; Egelman, Edward; Chen, Junjie; Sung, Patrick; Schild, D.

2010-08-24T23:59:59.000Z

193

Towards breaking temperature equilibrium in multi-component Eulerian schemes  

SciTech Connect (OSTI)

We investigate the effects ofthermal equilibrium on hydrodynamic flows and describe models for breaking the assumption ofa single temperature for a mixture of components in a cell. A computational study comparing pressure-temperature equilibrium simulations of two dimensional implosions with explicit front tracking is described as well as implementation and J-D calculations for non-equilibrium temperature methods.

Grove, John W [Los Alamos National Laboratory; Masser, Thomas [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

194

Vacuum condensates, flavor mixing and spontaneous supersymmetry breaking  

E-Print Network [OSTI]

Spontaneous supersymmetry (SUSY) breaking is revealed in all phenomena in which vacuum condensates are physically relevant. The dynamical breakdown of SUSY is generated by the condensates themselves, which lift the zero point energy. Evidence is presented in the case of the Wess-Zuimino model, and the flavor mixing case is treated in detail.

Antonio Capolupo; Marco Di Mauro

2013-01-05T23:59:59.000Z

195

BREAKING WITH OR BUILDING ON THE PAST? REFORMING IRISH PUBLIC  

E-Print Network [OSTI]

of the application of new public management styles to Ireland. Particular attention is paid to the public serviceBREAKING WITH OR BUILDING ON THE PAST? REFORMING IRISH PUBLIC ADMINISTRATION: 1958-2008 Niamh? REFORMING IRISH PUBLIC ADMINISTRATION: 1958-2008 Niamh Hardiman and Muiris MacCarthaigh Working Papers

196

Breaking the Hierarchy: Distributed Control & Economic Optimality in Microgrids  

E-Print Network [OSTI]

Breaking the Hierarchy: Distributed Control & Economic Optimality in Microgrids Florian D¨orfler. A preliminary version of part of the results in this document has been presented in [1]. F. D¨orfler is with the Department of Electrical Engineering, Uni- versity of California Los Angeles. Email: dorfler@seas.ucla.edu. J

Bullo, Francesco

197

Mechanisms of cellular symmetry breaking in S. cerevisiae  

E-Print Network [OSTI]

………………… … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … …..1 Chapter 2: Non ?uniform membrane diffusion enables steady?state cell polarization via vesicular trafficking………………………… … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … …..34 Chapter 3: Independence of symmetry breaking on... Bem1?mediated autocatalytic activation of Cdc42……………………… … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … ….88 Chapter 4: Preliminary data on Cdc42 microdomains in the presence of Rdi1 feedback………..135 Chapter 5...

Smith, Sarah Ellen

2013-12-31T23:59:59.000Z

198

EasyVoice: Breaking barriers for people with voice disabilities  

E-Print Network [OSTI]

disabilities. With the advances in computing power, new applications have been developed for helping peopleEasyVoice: Breaking barriers for people with voice disabilities Paulo A. Condado and Fernando G,flobo}@ualg.pt Abstract. Text-to-speech technology has been broadly used to help people with voice disabilities

Condado, Paulo

199

Structural Testing at the Micro and Nano Scales: Breaking  

E-Print Network [OSTI]

Structural Testing at the Micro and Nano Scales: Breaking Invisible Specimens With Zero Force). "Nano measurements with micro devices: mechanical properties of hydrated collagen fibrils," J. of the R tangential slots · Fuel swirls in the spin chamber and exits through the orifice in a hollow conical spray

Ballarini, Roberto

200

How does a thermal binary crystal break under shear?  

E-Print Network [OSTI]

When exposed to strong shearing, the particles in a crystal will rearrange and ultimately, the crystal will break by forming large nonaffine defects. Even for the initial stage of this process, only little effort has been devoted to the understanding of the breaking process on the scale of the individual particle size for thermalized mixed crystals. Here, we explore the shear-induced breaking for an equimolar two-dimensional binary model crystal with a high interaction asymmetry between the two different species such that the initial crystal has an intersecting square sublattice of the two constituents. Using Brownian dynamics computer simulations, we show that the combination of shear and thermal fluctuations leads to a characteristic hierarchical breaking scenario where initially, the more strongly coupled particles are thermally distorted, paving the way for the weakly coupled particles to escape from their cage. This in turn leads to mobile defects which may finally merge, proliferating a cascade of defects, which triggers the final breakage of the crystal. This scenario is in marked contrast to the breakage of one-component crystals close to melting. Moreover, we explore the orientational dependence of the initial shear direction relative to the crystal orientation and compare this to the usual melting scenario without shear. Our results are verifiable in real-space experiments of superparamagnetic colloidal mixtures at a pending air-water interface in an external magnetic field where the shear can be induced by an external laser field.

Tobias Horn; Hartmut Löwen

2014-11-21T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Building Cathedrals and Breaking down Reinforced Concrete Walls  

E-Print Network [OSTI]

Building Cathedrals and Breaking down Reinforced Concrete Walls Michel Brou´e Institut Henri distinction between great mathematicians Concrete walls breakers Michel Brou´e (Institut Henri Poincar´e) John Concrete walls breakers Cathedrals builders Michel Brou´e (Institut Henri Poincar´e) John Thompson

Broué, Michel - Institut de Mathématiques de Jussieu, Université Paris 7

202

1Banff 6/06 Structural Break Detection in Time Series ModelsStructural Break Detection in Time Series Models  

E-Print Network [OSTI]

breaks in this series? #12;5Banff 6/06 Introduction Examples AR GARCH Stochastic volatility State space Simulation results Applications Simulation results for GARCH and SV models #12;6Banff 6/06 Examples 1 ),,( 1 jjpj K #12;7Banff 6/06 Examples (cont) 2. Segmented GARCH model: where 0 = 1

203

FastFEM: Breaking Wave Impact on Ships Wave breaking and wave impact on maritime structures are difficult to model  

E-Print Network [OSTI]

with fine-scale dynamic air-water interfaces need to be modelled efficiently, including their interactions on fast ships. Faster ships have become more important in recent years. These include pilot ships, supply. Improved understanding of ship motion in heavy breaking seas is a key part of the larger project

Wirosoetisno, Djoko

204

Brain necrosis after fractionated radiation therapy: Is the halftime for repair longer than we thought?  

SciTech Connect (OSTI)

Purpose: To derive a radiobiological model that enables the estimation of brain necrosis and spinal cord myelopathy rates for a variety of fractionation schemes, and to compare repair effects between brain and spinal cord. Methods: Sigmoidal dose response relationships for brain radiation necrosis and spinal cord myelopathy are derived from clinical data using nonlinear regression. Three different repair models are considered and the repair halftimes are included as regression parameters. Results: For radiation necrosis, a repair halftime of 38.1 (range 6.9-76) h is found with monoexponential repair, while for spinal cord myelopathy, a repair halftime of 4.1 (range 0-8) h is found. The best-fit alpha beta ratio is 0.96 (range 0.24-1.73)Conclusions: A radiobiological model that includes repair corrections can describe the clinical data for a variety of fraction sizes, fractionation schedules, and total doses. Modeling suggests a relatively long repair halftime for brain necrosis. This study suggests that the repair halftime for late radiation effects in the brain may be longer than is currently thought. If confirmed in future studies, this may lead to a re-evaluation of radiation fractionation schedules for some CNS diseases, particularly for those diseases where fractionated stereotactic radiation therapy is used.

Bender, Edward T. [Department of Human Oncology, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, Wisconsin 53792 (United States)

2012-11-15T23:59:59.000Z

205

E-Print Network 3.0 - automobile repair shops Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: automobile repair shops Page: << < 1 2 3 4 5 > >> 1 Program Director: Jim Headlee Phone:...

206

E-Print Network 3.0 - activation repairs endothelial Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

aorta of the normal rabbit exhibits focal sites Summary: to repair this injury. Because fluid mechanical forces regulate such fundamental endothelial processes... PF. Shear...

207

E-Print Network 3.0 - auto body repair Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Repair Your source ... Source: Braun, Paul - Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign Collection: Materials Science 3 A Case...

208

Induction and Persistence of Large ?H2AX Foci by High Linear Energy Transfer Radiation in DNA-Dependent protein kinase–Deficient Cells  

SciTech Connect (OSTI)

Purpose: To evaluate the cell response to DNA double-strand breaks induced by low and high linear energy transfer (LET) radiations when the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), an essential protein of the nonhomologous end-joining repair pathway, lacks kinase activity. Methods and Materials: CHO10B2, a Chinese hamster ovary cell line, and its derived radiosensitive mutant cell line, irs-20, lacking DNA-PKcs activity, were evaluated after 0 to 3 Gy of ?-rays, plateau and Bragg peak protons, and lithium beams by clonogenic assay, and as a measurement of double-strand breaks, phosphorylated H2AX (?H2AX) foci number and size were quantified by immunocytofluorescence. Results: Irs-20 exhibited greater radiosensitivity and a higher amount of ?H2AX foci than CHO10B2 at 6 hours after irradiation for all types of radiations. Remarkably, CHO10B2 and irs-20 maintained their difference in radiosensitivity after high-LET radiation. Six hours after low-LET radiations, irs-20 did not reach basal levels of ?H2AX at high doses, whereas CHO10B2 recovered basal levels for all doses. After high-LET radiation, only CHO10B2 exhibited a reduction in ?H2AX foci, but it never reached basal levels. Persistent foci in irs-20 confirmed a repair deficiency. Interestingly, after 30 minutes of high-LET radiation both cell lines exhibited large foci (size >0.9 ?m{sup 2}) related to the damage nature, whereas at 6 hours irs-20 showed a higher amount of large foci than CHO10B2, with a 7-fold increase at 3 Gy, that could also be associated to radiosensitivity. Conclusions: We demonstrated, for the first time, an association between deficient DNA-PKcs activity and not only high levels of H2AX phosphorylation but also persistence and size increase of ?H2AX foci after high-LET irradiation.

Bracalente, Candelaria; Ibañez, Irene L. [Departamento de Micro y Nanotecnología, Comisión Nacional de Energía Atómica, San Martín, Buenos Aires (Argentina); Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires (Argentina); Molinari, Beatriz [Departamento de Radiobiología, Comisión Nacional de Energía Atómica, San Martín, Buenos Aires (Argentina); Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires (Argentina); Palmieri, Mónica [Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires (Argentina); Kreiner, Andrés [Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires (Argentina); Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, San Martín, Buenos Aires (Argentina); Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, San Martín, Buenos Aires (Argentina); Valda, Alejandro [Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, San Martín, Buenos Aires (Argentina); and others

2013-11-15T23:59:59.000Z

209

Repair welding of fusion reactor components. Final technical report  

SciTech Connect (OSTI)

The exposure of metallic materials, such as structural components of the first wall and blanket of a fusion reactor, to neutron irradiation will induce changes in both the material composition and microstructure. Along with these changes can come a corresponding deterioration in mechanical properties resulting in premature failure. It is, therefore, essential to expect that the repair and replacement of the degraded components will be necessary. Such repairs may require the joining of irradiated materials through the use of fusion welding processes. The present ITER (International Thermonuclear Experimental Reactor) conceptual design is anticipated to have about 5 km of longitudinal welds and ten thousand pipe butt welds in the blanket structure. A recent study by Buende et al. predict that a failure is most likely to occur in a weld. The study is based on data from other large structures, particularly nuclear reactors. The data used also appear to be consistent with the operating experience of the Fast Flux Test Facility (FFTF). This reactor has a fuel pin area comparable with the area of the ITER first wall and has experienced one unanticipated fuel pin failure after two years of operation. The repair of irradiated structures using fusion welding will be difficult due to the entrapped helium. Due to its extremely low solubility in metals, helium will diffuse and agglomerate to form helium bubbles after being trapped at point defects, dislocations, and grain boundaries. Welding of neutron-irradiated type 304 stainless steels has been reported with varying degree of heat-affected zone cracking (HAZ). The objectives of this study were to determine the threshold helium concentrations required to cause HAZ cracking and to investigate techniques that might be used to eliminate the HAZ cracking in welding of helium-containing materials.

Chin, B.A.; Wang, C.A.

1997-09-30T23:59:59.000Z

210

Blade reliability collaborative : collection of defect, damage and repair data.  

SciTech Connect (OSTI)

The Blade Reliability Collaborative (BRC) was started by the Wind Energy Technologies Department of Sandia National Laboratories and DOE in 2010 with the goal of gaining insight into planned and unplanned O&M issues associated with wind turbine blades. A significant part of BRC is the Blade Defect, Damage and Repair Survey task, which will gather data from blade manufacturers, service companies, operators and prior studies to determine details about the largest sources of blade unreliability. This report summarizes the initial findings from this work.

Ashwill, Thomas D.; Ogilvie, Alistair B.; Paquette, Joshua A.

2013-04-01T23:59:59.000Z

211

Experimental investigation of small-scale breaking waves : flow visualization across the air-water interface  

E-Print Network [OSTI]

The dynamics of breaking waves significantly affect air-sea fluxes of heat, momentum, mass and energy across the ocean interface. Breaking waves also contribute considerable loading to offshore and coastal structures, and ...

McDonald, Angus Kai

2005-01-01T23:59:59.000Z

212

Navier-Stokes simulations of steep breaking water waves with a coupled air-water interface  

E-Print Network [OSTI]

Wave breaking on the ocean surface significantly facilitates the transfer of mass, momentum, heat and energy across the air-sea interface. In the context of the near field flow about a surface ship, the breaking bow wave ...

Hendrickson, Kelli L

2005-01-01T23:59:59.000Z

213

Quantitative imaging of the air-water flow fields formed by unsteady breaking waves  

E-Print Network [OSTI]

An experimental method for simultaneously measuring the velocity fields on the air and water side of unsteady breaking waves is presented. The method is applied to breaking waves to investigate the physics of the air and ...

Belden, Jesse (Jesse Levi)

2009-01-01T23:59:59.000Z

214

U.S. Department of Energy Breaks Ground on State-of-the-Art Wind...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

U.S. Department of Energy Breaks Ground on State-of-the-Art Wind Turbine Test Facility U.S. Department of Energy Breaks Ground on State-of-the-Art Wind Turbine Test Facility...

215

Three dimensional effects in analysis of PWR steam line break accident  

E-Print Network [OSTI]

A steam line break accident is one of the possible severe abnormal transients in a pressurized water reactor. It is required to present an analysis of a steam line break accident in the Final Safety Analysis Report (FSAR) ...

Tsai, Chon-Kwo

216

Density driven symmetry breaking and Butterfly effect in holographic superconductors  

E-Print Network [OSTI]

We study the density driven symmetry breaking in holographic superconductors by considering the positive mass squared case. We show that even for the positive $m^2$, a scalar condensation still forms, provided the chemical potential is high enough. As $m^2$ increases, the phase space folds due to the non-linearity of the equations of motion, and two nearby points in the phase space can represent symmetry breaking and preserving configurations respectively. The phase space defined by the set of initial conditions of field variables at the horizon undergoes a non-linear radial evolution to result in the phase space folding, a characteristic phenomenon in a non-linear system. We then calculate the specific heat, which characterizes superconductors and has been measured in experiments.We observe a discontinuity in the specific heat at the transition point and compare our results with experimentally observed numbers. The electrical conductivity for various $m^2$ is also calculated.

Youngman Kim; Yumi Ko; Sang-Jin Sin

2009-12-01T23:59:59.000Z

217

The Environmental Impact of Lyman-break Galaxies  

E-Print Network [OSTI]

We perform cosmological simulations of galaxies forming at z=3 using the hydrodynamics grid code, Enzo. By selecting the largest galaxies in the volume to correspond to Lyman-break galaxies, we construct observational spectra of the HI flux distribution around these objects, as well as column densities of CIV and OVI throughout a refined region. We successfully reproduce the most recent observations of the mean HI flux in the close vicinity of Lyman-break galaxies but see no evidence for the proximity effect in earlier observations. While our galaxies do return metals to the IGM, their quantity and volume appears to be somewhat less than observed. We conclude that either we do not adequately resolve galactic winds, or that at least some of the intergalactic metal enrichment is by early epoch objects whose mass is smaller than our minimum resolved halo mass.

Elizabeth J. Tasker; Greg L. Bryan

2006-04-11T23:59:59.000Z

218

A Gravity Dual of Metastable Dynamical Supersymmetry Breaking  

SciTech Connect (OSTI)

Metastable, supersymmetry-breaking configurations can be created in flux geometries by placing antibranes in warped throats. Via gauge/gravity duality, such configurations should have an interpretation as supersymmetry-breaking states in the dual field theory. In this paper, we perturbatively determine the asymptotic supergravity solutions corresponding to D3-brane probes placed at the tip of the cascading warped deformed conifold geometry, which is dual to an SU(N+M) x SU(N) gauge theory. The backreaction of the antibranes has the effect of introducing imaginary anti-self-dual flux, squashing the compact part of the space and forcing the dilaton to run. Using the generalization of holographic renormalization to cascading geometries, we determine the expectation values of operators in the dual field theory in terms of the asymptotic values of the supergravity fields.

DeWolfe, Oliver; /Colorado U.; Kachru, Shamit; Mulligan, Michael; /Stanford U., Phys. Dept. /SLAC

2008-02-04T23:59:59.000Z

219

Landscape of Supersymmetry Breaking Vacua in Geometrically Realized Gauge Theories  

E-Print Network [OSTI]

We study vacuum structure of N=1 supersymmetric quiver gauge theories which can be realized geometrically by D brane probes wrapping cycles of local Calabi-Yau three-folds. In particular, we show that the A_2 quiver theory with gauge group U(N_1) \\times U(N_2) with N_1 / 2 landscape of inequivalent meta-stable vacua where supersymmetry is dynamically broken and all the moduli are stabilized. Each vacuum has distinct unbroken gauge symmetry. B-terms generated by the supersymmetry breaking give rise to gaugino masses at one-loop, and we are left with the bosonic pure Yang-Mills theory in the infrared. We also identify the supersymmetric vacua in this model using their infrared free descriptions and show that the decay rates of the supersymmetry breaking vacua into the supersymmetric vacua can be made parametrically small.

Hirosi Ooguri; Yutaka Ookouchi

2006-07-07T23:59:59.000Z

220

GENTLE IONISATION AND VIOLENT BREAK-UP OF MOLECULES USING SOFT X-RAYS  

E-Print Network [OSTI]

GENTLE IONISATION AND VIOLENT BREAK-UP OF MOLECULES USING SOFT X-RAYS Bhas Bapat PRL, Ahmedabad RRCAT Indore, June 2012 BHAS BAPAT (PRL, AHMEDABAD) BREAK-UP OF MOLECULES USING SOFT X-RAYS RRCAT INDORE INVESTIGATED RECENT RESULTS BHAS BAPAT (PRL, AHMEDABAD) BREAK-UP OF MOLECULES USING SOFT X-RAYS RRCAT INDORE

Bapat, Bhas

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Modeling suggests that oblique extension facilitates rifting and continental break-up  

E-Print Network [OSTI]

Modeling suggests that oblique extension facilitates rifting and continental break-up Sascha Brune; accepted 5 June 2012; published 2 August 2012. [1] In many cases the initial stage of continental break-up was and is associated with oblique rifting. That includes break-up in the Southern and Equatorial Atlantic, separation

Kaus, Boris

222

Gauge/gravity Duality and MetastableDynamical Supersymmetry Breaking  

SciTech Connect (OSTI)

We engineer a class of quiver gauge theories with several interesting features by studying D-branes at a simple Calabi-Yau singularity. At weak 't Hooft coupling we argue using field theory techniques that these theories admit both supersymmetric vacua and meta-stable non-supersymmetric vacua, though the arguments indicating the existence of the supersymmetry breaking states are not decisive. At strong 't Hooft coupling we find simple candidate gravity dual descriptions for both sets of vacua.

Argurio, Riccardo; Bertolini, Matteo; Franco, Sebastian; Kachru, Shamit

2006-10-24T23:59:59.000Z

223

FLASH predictions of the MB-2 steam line break tests  

SciTech Connect (OSTI)

If a main steam line from a pressurized water reactor (PWR) steam generator were to rupture, the effect would be a depressurization of the secondary side and a consequential overcooling transient on the primary side. Analyses must accurately predict the effects of the rapid cooldown of the reactor vessel coolant on positive nuclear-kinetic reactivity feedback to the core plus thermal shock to the reactor vessel and other primary system components. Many early studies of the steam line break (SLB) transient made extremely conservative assumptions to maximize the primary to secondary heat transfer which in turn maximized the reactor vessel cooldown rate. Among the more significant of these assumptions was that flow from the break was pure steam and that the tube bundle remained covered until the secondary mass inventory was significantly reduced. The Model F commercial PWR steam generator testing performed in the Model Boiler No. 2 (MB-2) facility located at the Westinghouse Engineering Test Facility in Tampa, Florida provided data to better qualify the actual variation in these key parameters. A conclusion of this analysis is that the MB-2 steam line break data base is accurate and of sufficient detail to provide a valuable basis for making comparisons relative to code predictions. Results obtained using the FLASH transient safety analysis code were found to be in excellent agreement with the data.

Lincoln, F.W.; Coffield, R.D.; Johnson, E.G.

1992-12-31T23:59:59.000Z

224

Identification and Dissection of a Complex DNA Repair Sensitivity Phenotype in Baker's Yeast  

E-Print Network [OSTI]

Identification and Dissection of a Complex DNA Repair Sensitivity Phenotype in Baker's Yeast Ann-assisted bulk segregant analysis, we identified one other locus, MKT1, and a QTL on Chromosome VII that also) Identification and Dissection of a Complex DNA Repair Sensitivity Phenotype in Baker's Yeast. PLoS Genet 4(7): e

Kruglyak, Leonid

225

Lazy Means Smart: Reducing Repair Bandwidth Costs in Erasure-coded Distributed Storage  

E-Print Network [OSTI]

- ditional bandwidth savings. 1. INTRODUCTION Erasure coding schemes, e.g. Reed-Solomon (RS) codes on the example of Reed-Solomon codes, and then explain the repair bandwidth problem. In an RS(n,k) stor- age scheme. 4. EVALUATION METHODOLOGY Evaluating the efficacy of lazy recovery in reducing repair bandwidth

Alvisi, Lorenzo

226

A Centralized, TreeBased Approach to Network Repair Service for Multicast Streaming Media  

E-Print Network [OSTI]

transmission, and can forward (via unicast) packets to other repair servers that did not receive the packets via the original transmission. After a fixed delay on the order of several seconds, a repair server with a transmission that is delayed by a few seconds relative to the original multicast session. However, this delayed

Maxemchuk, Nicholas F.

227

4 CONCRETE REPAIR BULLETIN MAY/JUNE2001 Laser Profilometry for  

E-Print Network [OSTI]

4 CONCRETE REPAIR BULLETIN MAY/JUNE2001 Laser Profilometry for Concrete Substrate Characterization and resins are non- corrosive, they are ideally suited for the repair and retrofitting of concrete bridges highly upon the quality of the bond between the concrete and the laminate. Experience has shown that when

Maerz, Norbert H.

228

Optimizing Repair Programs for Consistent Query Answering Monica Caniupan and Leopoldo Bertossi  

E-Print Network [OSTI]

, a logic programming system that implements the stable models semantics, in particular. We also analyze be restored minimally by inserting Q(a) or elim- inating S(a). The repair program contains the following 1Optimizing Repair Programs for Consistent Query Answering Monica Caniupan and Leopoldo Bertossi

Bertossi, Leopoldo

229

Injection repair of carbon fiber/bismaleimide composite panels with bisphenol E cyanate ester resin  

SciTech Connect (OSTI)

Resin injection of bisphenol E cyanate ester, a low viscosity resin that cures into a high temperature thermoset polymer, is investigated as a reliable repair method to restore strength and stiffness in delaminated carbon fiber/bismaleimide composites used in aircraft panels. The influence of temperature on the viscosity of the uncured resin was measured to optimize the injection conditions for high resin infiltration into the delaminations. The repair efficiency of the resin was evaluated by varying the panel thickness and the method by which the delamination damage was created in the composite specimens. Ultrasonic scanning (C-scan), flash thermography images, and cross-section analysis of repaired panels revealed excellent resin infiltration into the damaged region. Evaluation of mechanical repair efficiency using both bending stiffness and in-plain compressive strength of the composite panels as the repair metrics showed values exceeding 100%.

Thunga, Mahendra [Ames Laboratory; Bauer, Amy [Iowa State University; Obusek, Kristine [Fleet Readiness Center East; Meilunas, Ray [Naval Air Warfare Center Aircraft Division; Akinc, Mufit [Ames Laboratory; Kessler, Michael R [Ames Laboratory

2014-08-01T23:59:59.000Z

230

Repair of gamma-ray-induced DNA base damage in xeroderma pigmentosum cells  

SciTech Connect (OSTI)

The repair of DNA damage produced by /sup 137/Cs gamma irradiation was measured with a preparation from Micrococcus luteus containing DNA damage-specific endonucleases in combination with alkaline elution. The frequency of these endonuclease sensitive sites (ESS) was determined after 54 or 110 Gy of oxic irradiation in normal and xeroderma pigmentosum (XP) fibroblasts from complementation groups A, C, D, and G. Repair was rapid in all cell strains with greater than 50% repair after 1.5 h of repair incubation. At later repair times, 12-17 h, more ESS remained in XP than in normal cells. The frequency of excess ESS in XP cells was approximately 0.04 per 10(9) Da of DNA per Gy which was equivalent to 10% of the initial ESS produced. The removal of ESS was comparable in XP cells with normal radiosensitivity and XP3BR cells which have been reported to be moderately radiosensitive.

Fornace, A.J. Jr.; Dobson, P.P.; Kinsella, T.J.

1986-04-01T23:59:59.000Z

231

Experience in the repair of steam generator auxiliary feedwater nozzle  

SciTech Connect (OSTI)

The auxiliary feedwater nozzle is quite often subjected to more thermal stress cycles and other loading mechanisms during their service life than the material was designed and fabricated for at the nozzle of the earlier steam generators in many nuclear plants. During plant operation, the auxiliary feedwater nozzle outlet is exposed to the hot steam from the generator side, while the auxiliary feedwater piping which contains subcooled water from the inlet often induces water hammer as a result of the steam-water mixing phenomena. The thermal cycles and the steam bubble collapse at the nozzle may cause cracking in the nozzle liner and interior surface of the nozzle, and subsequently results in structural damage to the steam generator. This presentation is intended to share the lessons learned from the evaluation of the nozzle condition and the subsequent modification and repair made to the auxiliary feedwater nozzle at the Palisades Nuclear Plant. Other nuclear plant owners may benefit from this experience.

Chao, K.K.N. [Consumers Power Co., Jackson, MI (United States)

1996-12-01T23:59:59.000Z

232

Method of tissue repair using a composite material  

DOE Patents [OSTI]

A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

Hutchens, Stacy A; Woodward, Jonathan; Evans, Barbara R; O'Neill, Hugh M

2014-03-18T23:59:59.000Z

233

Assessing the Risk of Mercury in Drinking Water after UV Lamp Breaks Page 1 Assessing the Risk of Mercury in Drinking Water after UV Lamp Breaks  

E-Print Network [OSTI]

Assessing the Risk of Mercury in Drinking Water after UV Lamp Breaks Page 1 Assessing the Risk of Mercury in Drinking Water after UV Lamp Breaks Heidi Borchers University of New Hampshire, Environmental Ultraviolet (UV) lamps generate ultraviolet light through the vaporization of elemental mercury, by using

234

Neurological Complications Following Endoluminal Repair of Thoracic Aortic Disease  

SciTech Connect (OSTI)

Open surgery for thoracic aortic disease is associated with significant morbidity and the reported rates for paraplegia and stroke are 3%-19% and 6%-11%, respectively. Spinal cord ischemia and stroke have also been reported following endoluminal repair. This study reviews the incidence of paraplegia and stroke in a series of 186 patients treated with thoracic stent grafts. From July 1997 to September 2006, 186 patients (125 men) underwent endoluminal repair of thoracic aortic pathology. Mean age was 71 years (range, 17-90 years). One hundred twenty-eight patients were treated electively and 58 patients had urgent procedures. Anesthesia was epidural in 131, general in 50, and local in 5 patients. Seven patients developed paraplegia (3.8%; two urgent and five elective). All occurred in-hospital apart from one associated with severe hypotension after a myocardial infarction at 3 weeks. Four of these recovered with cerebrospinal fluid (CSF) drainage. One patient with paraplegia died and two had permanent neurological deficit. The rate of permanent paraplegia and death was 1.6%. There were seven strokes (3.8%; four urgent and three elective). Three patients made a complete recovery, one had permanent expressive dysphasia, and three died. The rate of permanent stroke and death was 2.1%. Endoluminal treatment of thoracic aortic disease is an attractive alternative to open surgery; however, there is still a risk of paraplegia and stroke. Permanent neurological deficits and death occurred in 3.7% of the patients in this series. We conclude that prompt recognition of paraplegia and immediate insertion of a CSF drain can be an effective way of recovering spinal cord function and improving the prognosis.

Morales, J. P.; Taylor, P. R.; Bell, R. E.; Chan, Y. C. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Sabharwal, T. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom); Carrell, T. W. G. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Reidy, J. F. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom)], E-mail: John.Reidy@gstt.nhs.uk

2007-09-15T23:59:59.000Z

235

CMB Anisotropies from Outflows in Lyman Break Galaxies  

E-Print Network [OSTI]

Thomson scattering of the Cosmic Microwave Background (CMB) on moving electrons in the outflows of Lyman Break Galaxies (LBGs) at redshifts 2-8 contributes to the small-scale CMB anisotropies. The net effect produced by each outflow depends on its level of deviation from spherical symmetry, caused either by an anisotropic energy injection from the nuclear starburst or quasar activity, or by an inhomogeneous intergalactic environment. We find that for plausible outflow parameters consistent with spectroscopic observations of LBGs, the induced CMB anisotropies on arcminute scales reach up to $\\sim 1 \\mu$K, comparable to the level produced during the epoch of reionization.

Daniel Babich; Abraham Loeb

2006-09-14T23:59:59.000Z

236

CPT- and Lorentz-symmetry breaking: a review  

E-Print Network [OSTI]

The breakdown of spacetime symmetries has recently been identified as a promising candidate signal for underlying physics, possibly arising through quantum-gravitational effects. This talk gives an overview over various aspects of CPT- and Lorentz-violation research. Particular emphasis is given to the interplay between CPT, Lorentz, and translation symmetry, mechanisms for CPT and Lorentz breaking, and the construction of a low-energy quantum-field description of such effect. This quantum field framework, called the SME, is employed to determine possible phenomenological consequences of CPT and Lorentz violation for neutral-meson interferometry.

Ralf Lehnert

2006-12-28T23:59:59.000Z

237

Q-ball Instability due to U(1) Breaking  

E-Print Network [OSTI]

Q-ball is a non-topological soliton whose stability is ensured by global U(1) symmetry. We study a Q-ball which arises in the Affleck-Dine mechanism for baryogenesis and consider its possible instability due to U(1) breaking term ($A$-term) indispensable for successful baryogenesis. It is found that the instability destroys the Q-ball if its growth rate exceeds inverse of the typical relaxation time scale of the Q-ball. However, the instability is not so strong as it obstructs the cosmological formation of the Q-balls.

Masahiro Kawasaki; Kenichiro Konya; Fuminobu Takahashi

2005-05-24T23:59:59.000Z

238

Leak before break application in French PWR plants under operation  

SciTech Connect (OSTI)

Practical applications of the leak-before break concept are presently limited in French Pressurized Water Reactors (PWR) compared to Fast Breeder Reactors. Neithertheless, different fracture mechanic demonstrations have been done on different primary, auxiliary and secondary PWR piping systems based on similar requirements that the American NUREG 1061 specifications. The consequences of the success in different demonstrations are still in discussion to be included in the global safety assessment of the plants, such as the consequences on in-service inspections, leak detection systems, support optimization,.... A large research and development program, realized in different co-operative agreements, completes the general approach.

Faidy, C. [EDF SEPTEN, Villeurbanne (France)

1997-04-01T23:59:59.000Z

239

Spontaneous symmetry breaking and optimization of functional renormalization group  

E-Print Network [OSTI]

The requirement for the absence of spontaneous symmetry breaking in the d=1 dimension has been used to optimize the regulator dependence of functional renormalization group equations in the framework of the sine-Gordon scalar field theory. Results obtained by the optimization of this kind were compared to those of the Litim-Pawlowski and the principle of minimal sensitivity optimization scenarios. The optimal parameters of the compactly supported smooth (CSS) regulator, which recovers all major types of regulators in appropriate limits, have been determined beyond the local potential approximation, and the Litim limit of the CSS was found to be the optimal choice.

I. Nandori; I. G. Marian; V. Bacso

2014-02-27T23:59:59.000Z

240

Spontaneous symmetry breaking and collapse in bosonic Josephson junctions  

SciTech Connect (OSTI)

We investigate an attractive atomic Bose-Einstein condensate (BEC) trapped by a double-well potential in the axial direction and by a harmonic potential in the transverse directions. We obtain numerically a quantum phase diagram which includes all the three relevant phases of the system: Josephson, spontaneous symmetry breaking (SSB), and collapse. We consider also the coherent dynamics of the BEC and calculate the frequency of population-imbalance mode in the Josephson phase and in the SSB phase up to the collapse. We show that these phases can be observed by using ultracold vapors of {sup 7}Li atoms in a magneto-optical trap.

Mazzarella, Giovanni [Dipartimento di Fisica 'Galileo Galilei' and Consorzio Nazionale Interuniversitatio per le Scienze Fisiche della Materia (CNISM), Universita di Padova, Via Marzolo 8, I-35122 Padova (Italy); Salasnich, Luca [Dipartimento di Fisica ''Galileo Galilei'' and Consorzio Nazionale Interuniversitatio per le Scienze Fisiche della Materia (CNISM), Universita di Padova, Via Marzolo 8, I-35122 Padova (Italy); Istituto Nazionale di Ottica (INO) del Consiglio Nazionale delle Ricerche (CNR), Research Unit at Padova, Via Marzolo 8, I-35122 Padova (Italy); Center for Applied Mathematics and Theoretical Physics, University of Maribor, Krekova 2, SI-2000 Maribor (Slovenia)

2010-09-15T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Charge symmetry breaking in n p --> d pi^0  

E-Print Network [OSTI]

The forward--backward asymmetry in n p --> d pi^0, which must be zero in the center-of-mass system if charge symmetry is respected, has been measured to be [17.2 +/- 8 (stat) +/- 5.5 (sys)] * 10^{-4}, at an incident neutron energy of 279.5 MeV. This charge symmetry breaking observable was extracted by fitting the data with GEANT-based simulations and is compared to recent chiral effective field theory calculations, with implications regarding the value of the u d quark mass difference.

A. K. Opper; E. Korkmaz; D. A. Hutcheon; R. Abegg; C. A. Davis; R. W. Finlay; P. W. Green; L. G. Greeniaus; D. V. Jordan; J. A. Niskanen; G. V. O'Rielly; T. A. Porcelli; S. D. Reitzner; P. L. Walden; S. Yen

2003-06-19T23:59:59.000Z

242

Ground Breaking of Blythe Solar Power Project | Department of Energy  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power.pdf11-161-LNG | Department of EnergyGeothermalGoing OffGreen LeaseBreaking of Blythe

243

Breaking a Pocket of Resistance in the Fight Against Cancer  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone6 M.ExtracellularBradbury Science MuseumBrainBreaking a Pocket

244

Breaking the ties that bind: New hope for biomass fuels  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone6 M.ExtracellularBradbury Science MuseumBrainBreaking aNew hope

245

SB Electronics Breaks Ground on New Factory | Department of Energy  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAXBalancedDepartmentRestrictions onSB Electronics Breaks Ground on New Factory SB

246

Breaking the Biological Barriers to Cellulosic Ethanol, June 2006  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartmentTie Ltd: ScopeDepartment1, DOE/SC-0095 Breakng the

247

Symmetry Breaking of H2 Dissociation by a Single Photon  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassiveSubmittedStatus TomAbout »LabSustainability Ames LaboratorySymmetry Breaking

248

Development and validation of bonded composite doubler repairs for commercial aircraft.  

SciTech Connect (OSTI)

A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack, impact, and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safely extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC), Boeing, and Federal Express completed a pilot program to validate and introduce composite doubler repair technology to the U.S. commercial aircraft industry. This project focused on repair of DC-10 fuselage structure and its primary goal was to demonstrate routine use of this repair technology using niche applications that streamline the design-to-installation process. As composite doubler repairs gradually appear in the commercial aircraft arena, successful flight operation data is being accumulated. These commercial aircraft repairs are not only demonstrating the engineering and economic advantages of composite doubler technology but they are also establishing the ability of commercial maintenance depots to safely adopt this repair technique. This report presents the array of engineering activities that were completed in order to make this technology available for widespread commercial aircraft use. Focused laboratory testing was conducted to compliment the field data and to address specific issues regarding damage tolerance and flaw growth in composite doubler repairs. Fatigue and strength tests were performed on a simulated wing repair using a substandard design and a flawed installation. In addition, the new Sol-Gel surface preparation technique was evaluated. Fatigue coupon tests produced Sol-Gel results that could be compared with a large performance database from conventional, riveted repairs. It was demonstrated that not only can composite doublers perform well in severe off-design conditions (low doubler stiffness and presence of defects in doubler installation) but that the Sol-Gel surface preparation technique is easier and quicker to carry out while still producing optimum bonding properties. Nondestructive inspection (NDI) methods were developed so that the potential for disbond and delamination growth could be monitored and crack growth mitigation could be quantified. The NDI methods were validated using full-scale test articles and the FedEx aircraft installations. It was demonstrated that specialized NDI techniques can detect flaws in composite doubler installations before they reach critical size. Probability of Detection studies were integrated into the FedEx training in order to quantify the ability of aircraft maintenance depots to properly monitor these repairs. In addition, Boeing Structural Repair and Nondestructive Testing Manuals were modified to include composite doubler repair and inspection procedures. This report presents the results from the FedEx Pilot Program that involved installation and surveillance of numerous repairs on operating aircraft. Results from critical NDI evaluations are reported in light of damage tolerance assessments for bonded composite doublers. This work has produced significant interest from airlines and aircraft manufacturers. The successful Pilot Program produced flight performance history to establish the durability of bonded composite patches as a permanent repair on commercial aircraft structures. This report discusses both the laboratory data and Pilot Program results from repair installations on operating aircraft to introduce composite doubler repairs into mainstream commercial aircraft use.

Roach, Dennis Patrick; Rackow, Kirk A.

2007-07-01T23:59:59.000Z

249

Fabrication Flaw Density and Distribution In Repairs to Reactor Pressure Vessel and Piping Welds  

SciTech Connect (OSTI)

The Pacific Northwest National Laboratory is developing a generalized fabrication flaw distribution for the population of nuclear reactor pressure vessels and for piping welds in U.S. operating reactors. The purpose of the generalized flaw distribution is to predict component-specific flaw densities. The estimates of fabrication flaws are intended for use in fracture mechanics structural integrity assessments. Structural integrity assessments, such as estimating the frequency of loss-of-coolant accidents, are performed by computer codes that require, as input, accurate estimates of flaw densities. Welds from four different reactor pressure vessels and a collection of archived pipes have been studied to develop empirical estimates of fabrication flaw densities. This report describes the fabrication flaw distribution and characterization in the repair weld metal of vessels and piping. This work indicates that large flaws occur in these repairs. These results show that repair flaws are complex in composition and sometimes include cracks on the ends of the repair cavities. Parametric analysis using an exponential fit is performed on the data. The relevance of construction records is established for describing fabrication processes and product forms. An analysis of these records shows there was a significant change in repair frequency over the years when these components were fabricated. A description of repair flaw morphology is provided with a discussion of fracture mechanics significance. Fabrication flaws in repairs are characterized using optimized-access, high-sensitivity nondestructive ultrasonic testing. Flaw characterizations are then validated by other nondestructive evaluation techniques and complemented by destructive testing.

GJ Schuster, FA Simonen, SR Doctor

2008-04-01T23:59:59.000Z

250

Pulsar Emission above the Spectral Break - A Stacked Approach  

E-Print Network [OSTI]

NASA's Fermi space telescope has provided us with a bountiful new population of gamma-ray sources following its discovery of 150 new gamma-ray pulsars. One common feature exhibited by all of these pulsars is the form of their spectral energy distribution, which can be described by a power law followed by a spectral break occurring between $\\sim$1 and $\\sim$8 GeV. The common wisdom is that the break is followed by an exponential cut-off driven by radiation/reaction-limited curvature emission. The discovery of pulsed gamma rays from the Crab pulsar, the only pulsar so far detected at very high energies (E$>$100GeV), contradicts this "cutoff" picture. Here we present a new stacked analysis with an average of 4.2 years of data on 115 pulsars published in the 2nd LAT catalog of pulsars. This analysis is sensitive to low-level $\\sim$100 GeV emission which cannot be resolved in individual pulsars but can be detected from an ensemble.

McCann, Andrew

2015-01-01T23:59:59.000Z

251

Bending-induced Symmetry Breaking of Lithiation in Germanium Nanowires  

SciTech Connect (OSTI)

From signal transduction of living cells to oxidation and corrosion of metals, mechanical stress intimately couples with chemical reactions, regulating these biological and physiochemical processes. The coupled effect is particularly evident in electrochemical lithiation/delithiation cycling of high-capacity electrodes, such as silicon (Si), where on one hand lithiation-generated stress mediates lithiation kinetics, and on the other electrochemical reaction rate regulates stress generation and mechanical failure of the electrodes. Here we report for the first time the evidence on the controlled lithiation in germanium nanowires (GeNWs) through external bending. Contrary to the symmetric core-shell lithiation in free-standing GeNWs, we show bending GeNWs breaks the lithiation symmetry, speeding up lithaition at the tensile side while slowing down at the compressive side of the GeNWs. The bending-induced symmetry breaking of lithiation in GeNWs is further corroborated by chemomechanical modeling. In the light of the coupled effect between lithiation kinetics and mechanical stress in the electrochemical cycling, our findings shed light on strain/stress engineering of durable high-rate electrodes and energy harvesting through mechanical motion.

Gu, Meng; Yang, Hui; Perea, Daniel E.; Zhang, Jiguang; Zhang, Sulin; Wang, Chong M.

2014-08-01T23:59:59.000Z

252

Aerosol cluster impact and break-up : model and implementation.  

SciTech Connect (OSTI)

In this report a model for simulating aerosol cluster impact with rigid walls is presented. The model is based on JKR adhesion theory and is implemented as an enhancement to the granular (DEM) package within the LAMMPS code. The theory behind the model is outlined and preliminary results are shown. Modeling the interactions of small particles is relevant to a number of applications (e.g., soils, powders, colloidal suspensions, etc.). Modeling the behavior of aerosol particles during agglomeration and cluster dynamics upon impact with a wall is of particular interest. In this report we describe preliminary efforts to develop and implement physical models for aerosol particle interactions. Future work will consist of deploying these models to simulate aerosol cluster behavior upon impact with a rigid wall for the purpose of developing relationships for impact speed and probability of stick/bounce/break-up as well as to assess the distribution of cluster sizes if break-up occurs. These relationships will be developed consistent with the need for inputs into system-level codes. Section 2 gives background and details on the physical model as well as implementations issues. Section 3 presents some preliminary results which lead to discussion in Section 4 of future plans.

Lechman, Jeremy B.

2010-10-01T23:59:59.000Z

253

CSNI specialist meeting on leak-before-break in nuclear reactor piping: proceedings  

SciTech Connect (OSTI)

On September 1 and 2, 1983, the CSNI subcommittee on primary system integrity held a special meeting in Monterey, California, on the subject of leak-before-break in nuclear reactor piping systems. The purpose of the meeting was to provide an international forum for the exchange of ideas, positions, and research results; to identify areas requiring additional research and development; and to determine the general attitude toward acceptance of the leak-before-break concept. The importance of the leak-before-break issue was evidenced by excellent attendance at the meeting and through active participation by the meeting attendees. Approximately 125 people representing fifteen different nations attended the meeting. The meeting was divided into four technical sessions addressing the following areas: Application of Piping Fracture Mechanics to Leak-Before Break, Leak Rate and Leak Detection, Leak-Before-Break Studies, Methods and Results, Current and Proposed Positions on Leak-Before-Break.

Not Available

1984-08-01T23:59:59.000Z

254

Analytical Derivation of Three Dimensional Vorticity Function for wave breaking in Surf Zone  

E-Print Network [OSTI]

In this report, Mathematical model for generalized nonlinear three dimensional wave breaking equations was de- veloped analytically using fully nonlinear extended Boussinesq equations to encompass rotational dynamics in wave breaking zone. The three dimensional equations for vorticity distributions are developed from Reynold based stress equations. Vorticity transport equations are also developed for wave breaking zone. This equations are basic model tools for numerical simulation of surf zone to explain wave breaking phenomena. The model reproduces most of the dynamics in the surf zone. Non linearity for wave height predictions is also shown close to the breaking both in shoaling as well as surf zone. Keyword Wave breaking, Boussinesq equation, shallow water, surf zone. PACS : 47.32-y

Dutta, R

2015-01-01T23:59:59.000Z

255

Lack of Bystander Effects From High LET Radiation For Early Cytogenetic Endpoints.  

SciTech Connect (OSTI)

The aim of this work was to study radiation-induced bystander effects for early cytogenetic end points in various cell lines using the medium transfer technique after exposure to high- and low-LET radiation. Cells were exposed to 20 MeV/ nucleon nitrogen ions, 968 MeV/nucleon iron ions, or 575 MeV/nucleon iron ions followed by transfer of the conditioned medium from the irradiated cells to unirradiated test cells. The effects studied included DNA double-strand break induction, {gamma}-H2AX focus formation, induction of chromatid breaks in prematurely condensed chromosomes, and micronucleus formation using DNA repair-proficient and -deficient hamster and human cell lines (xrs6, V79, SW48, MO59K and MO59J). Cell survival was also measured in SW48 bystander cells using X rays. Although it was occasionally possible to detect an increase in chromatid break levels using nitrogen ions and to see a higher number of {gamma}-H2AX foci using nitrogen and iron ions in xrs6 bystander cells in single experiments, the results were not reproducible. After we pooled all the data, we could not verify a significant bystander effect for any of these end points. Also, we did not detect a significant bystander effect for DSB induction or micronucleus formation in these cell lines or for clonogenic survival in SW48 cells. The data suggest that DNA damage and cytogenetic changes are not induced in bystander cells. In contrast, data in the literature show pronounced bystander effects in a variety of cell lines, including clonogenic survival in SW48 cells and induction of chromatid breaks and micronuclei in hamster cells. To reconcile these conflicting data, it is possible that the epigenetic status of the specific cell line or the precise culture conditions and medium supplements, such as serum, may be critical for inducing bystander effects.

Groesser, Torsten; Cooper, Brian; Rydberg, Bjorn

2008-05-07T23:59:59.000Z

256

ON THE EVOLUTION OF THE SPECTRAL BREAK IN THE AFTERGLOW OF GAMMA-RAY BURSTS  

SciTech Connect (OSTI)

The temporal evolution of the spectral break in the time-resolved spectral energy density of the broadband afterglow of gamma-ray bursts (GRBs) 091127 and 080319B was shown recently to be inconsistent with that expected for the cooling break in the standard fireball model of GRBs. Here we show that it is, however, in good agreement with the predicted temporal evolution of the smooth injection break/bend in the cannonball model of GRBs.

Dado, Shlomo; Dar, Arnon [Physics Department, Technion, Haifa 32000 (Israel)

2012-02-20T23:59:59.000Z

257

Community-Minded Interns at Savannah River Site Help Area Residents in Need with Home Repairs  

Broader source: Energy.gov [DOE]

AIKEN, S.C. – More than two dozen college interns who worked at the Savannah River Site (SRS) this summer joined other volunteers and headed into area neighborhoods to help people in need with home repairs.

258

Use of CFRP Overlays to Repair Fatigue Damage in Steel Bridge Girders and Components  

E-Print Network [OSTI]

Fatigue damage in steel girder bridges built prior to the mid-1980s is common due to distortion-induced fatigue. Different repair techniques have been developed and implemented to retrofit bridges of this era with existing fatigue damage...

Gangel, Regan Elisabeth

2012-05-31T23:59:59.000Z

259

USE OF COMPOSITE MATERIALS TO REPAIR STEEL STRUCTURES VULNERABLE TO FATIGUE DAMAGE  

E-Print Network [OSTI]

This study investigates mainly two different topics related to the use of CFRP's for strengthening and repair of steel bridges: the use of CFRP's to prevent damage in fatigue vulnerable welded connections prior to fatigue-crack initiation...

Alemdar, Fatih

2010-01-01T23:59:59.000Z

260

Consistency Management with Repair Actions Christian Nentwich, Wolfgang Emmerich and Anthony Finkelstein  

E-Print Network [OSTI]

Consistency Management with Repair Actions Christian Nentwich, Wolfgang Emmerich and Anthony Finkelstein Department of Computer Science University College London Gower Street, London WC1E 6BT, UK {c.nentwich,w.emmerich

van der Hoek, André

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Project: UAF Utilities Waste Line Repairs Ch6 to Ch13 Project No: 2013101 UTWH  

E-Print Network [OSTI]

Project: UAF Utilities Waste Line Repairs Ch6 to Ch13 Project No: 2013101 UTWH Subject: Project Schedule Project Duration: May 27 to August 10, 2014 The sewer line will be constructed in phases

Ickert-Bond, Steffi

262

E-Print Network 3.0 - aortic repair pushing Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for: aortic repair pushing Page: << < 1 2 3 4 5 > >> 1 Mechanobiology of the Aortic Heart Valve Jonathan T. Butcher1 Summary: ;13:798-803 18. Deck JD, Thubrikar MJ, Schneider...

263

Using 3D Painting to Build and Repair Parts | GE Global Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

spray as an alternate way to repair or coat parts involved in oil and gas drilling and turbo machinery. Cold spray's future benefits include extended product lifespan and reduced...

264

Review of Maintenance and Repair Times for Components in Technological Facilities  

SciTech Connect (OSTI)

This report is a compilation of some unique component repair time data and it also presents citations of more extensive reports where lists of repair times can be found. This collection of information should support analysts who seek to quantify maintainability and availability of high technology and nuclear energy production systems. While there are newer sources of repair time information, most, if not all, of the newer sources are proprietary and cannot be shared. This report offers data that, while older, is openly accessible and can serve as reasonable estimates of repair times, at least for initial studies. Some times were found for maintenance times in radiation environments, and some guidance for multiplicative factors to use to account for work in contamination areas.

L. C. Cadwallader

2012-11-01T23:59:59.000Z

265

Tiny Terminators: New Micro-Robots Assemble, Repair Themselves and Are Surprisingly Strong  

Broader source: Energy.gov [DOE]

Tiny robots that can assemble and repair themselves? Watch a video of Argonne National Laboratory's micro-robots that easily perform tasks that can challenge other robots, including moving objects that are larger than themselves.

266

Planetary Wave Breaking and Nonlinear Reflection: Seasonal Cycle and Interannual Variability  

E-Print Network [OSTI]

and L. M. Polvani, 2000: Climatology of intrusions into theM. H. Hitchman, 1999: A climatology of Rossby wave breaking

Abatzoglou, John T; Magnusdottir, Gudrun

2006-01-01T23:59:59.000Z

267

Bubbles Help Break Energy Storage Record for Lithium Air-Batteries  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bubbles Help Break Energy Storage Record for Lithium Air-Batteries Foam-base graphene keeps oxygen flowing in batteries that holds promise for electric vehicles January...

268

RESTORING A DAMAGED 16-YEAR -OLD INSULATING POLYMER CONCRETE DIKE OVERLAY: REPAIR MATERIALS AND TECHNOLOGIES.  

SciTech Connect (OSTI)

The objective of this program was to design and formulate organic polymer-based material systems suitable for repairing and restoring the overlay panels of insulating lightweight polymer concrete (ILPC) from the concrete floor and slope wall of a dike at KeySpan liquefied natural gas (LNG) facility in Greenpoint, Brooklyn, NY, just over sixteen years ago. It also included undertaking a small-scale field demonstration to ensure that the commercial repairing technologies were applicable to the designed and formulated materials.

SUGAMA,T.

2007-01-01T23:59:59.000Z

269

Endovascular Abdominal Aortic Aneurysm Repair in the Presence of a Kidney Transplant: Therapeutic Considerations  

SciTech Connect (OSTI)

Abdominal aortic aneurysm (AAA) repair in the presence of a kidney transplant can be extremely challenging, as it carries significant risks of renal ischemia. Endovascular repair is an attractive option, as it can be performed with little or no impairment of renal arterial flow. We describe the endovascular management of a recurrent AAA in a patient with a functioning renal transplant using a custom-made aorto-uni-iliac device. We discuss the planning and the potential problems of the technique.

Karkos, Christos D., E-mail: ckarkos@hotmail.com; McMahon, Greg [Leicester Royal Infirmary, Department of Vascular and Endovascular Surgery (United Kingdom); Fishwick, Guy [Leicester Royal Infirmary, Department of Radiology (United Kingdom); Lambert, Kelly; Bagga, Ajay; McCarthy, Mark J. [Leicester Royal Infirmary, Department of Vascular and Endovascular Surgery (United Kingdom)

2006-04-15T23:59:59.000Z

270

Slow elimination of phosphorylated histone {gamma}-H2AX from DNA of terminally differentiated mouse heart cells in situ  

SciTech Connect (OSTI)

Phosphorylation of replacement histone H2AX occurs in megabase chromatin domains around double-strand DNA breaks (DSBs) and this modification (called {gamma}-H2AX) may serve as a useful marker of genome damage and repair in terminally differentiated cells. Here using immunohistochemistry we studied kinetics of {gamma}-H2AX formation and elimination in the X-irradiated mouse heart and renal epithelial tissues in situ. Unirradiated tissues have 3-5% {gamma}-H2AX-positive cells and in tissues fixed 1 h after X-irradiation {gamma}-H2AX-positive nuclei are induced in a dose-dependent manner approaching 20-30% after 3 Gy of IR. Analysis of mouse tissues at different times after 3 Gy of IR showed that maximal induction of {gamma}-H2AX in heart is observed 20 min after IR and then is decreased slowly with about half remaining 23 h later. In renal epithelium maximum of the {gamma}-H2AX-positive cells is observed 40 min after IR and then decreases to control values in 23 h. This indicates that there are significant variations between non-proliferating mammalian tissues in the initial H2AX phosphorylation rate as well as in the rate of {gamma}-H2AX elimination after X-irradiation, which should be taken into account in the analysis of radiation responses.

Gavrilov, Boris [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Vezhenkova, Irina [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Firsanov, Denis [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Solovjeva, Liudmila [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Svetlova, Maria [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Mikhailov, Vyacheslav [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Tomilin, Nikolai [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation)]. E-mail: nvtom@hotmail.com

2006-09-08T23:59:59.000Z

271

the Adaptive Response, Genetic Haplo-Insufficiency and Genomic Instability  

SciTech Connect (OSTI)

The linear no-threshold (LNT) hypothesis is the driving force in the establishment of radiation protection standards. However, the scientific basis for linearity has been brought into question, particularly due to the concerns about induced radiation resistance as it pertains to oxidative stress. Specifically, we investigated the observation that tumor hypoxia is associated with malignant progression, increased metastases, chemo- and radioresistance and poor prognosis. Experiments were conducted with non-malignant 3T3/NIH cells and normal human lung fibroblasts (NHLF) that were subjected to ?-irradiation under the levels of oxygen resembling those in growing tumors, and related our data to the concentrations of dissolved oxygen (DO), which is a better indicator of the amounts of residual oxygen inside the cells cultured in the hypoxic or anoxic atmosphere. We found that at DO levels about 0.5 mg/L cells subjected to both short-term (17 hours) and prolonged (48-72 hours) hypoxia continued to proliferate, and that apoptotic events were decreased at the early hours of hypoxic treatment. We showed that the short-term hypoxia up-regulated p53-binding protein 1 (53BP1) and resulted in facilitated 53BP1 nuclear foci formation and disappearance, thus indicating the higher efficiency of DNA double strand breaks repair processes. The latter was confirmed by the lower micronuclei incidence in irradiated hypoxic cells.

Geard, Charles R.

2014-12-12T23:59:59.000Z

272

ExpandplusCrystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA  

SciTech Connect (OSTI)

Poly(ADP-ribose) polymerase-1 (PARP-1) has two homologous zinc finger domains, Zn1 and Zn2, that bind to a variety of DNA structures to stimulate poly(ADP-ribose) synthesis activity and to mediate PARP-1 interaction with chromatin. The structural basis for interaction with DNA is unknown, which limits our understanding of PARP-1 regulation and involvement in DNA repair and transcription. Here, we have determined crystal structures for the individual Zn1 and Zn2 domains in complex with a DNA double strand break, providing the first views of PARP-1 zinc fingers bound to DNA. The Zn1-DNA and Zn2-DNA structures establish a novel, bipartite mode of sequence-independent DNA interaction that engages a continuous region of the phosphodiester backbone and the hydrophobic faces of exposed nucleotide bases. Biochemical and cell biological analysis indicate that the Zn1 and Zn2 domains perform distinct functions. The Zn2 domain exhibits high binding affinity to DNA compared with the Zn1 domain. However, the Zn1 domain is essential for DNA-dependent PARP-1 activity in vitro and in vivo, whereas the Zn2 domain is not strictly required. Structural differences between the Zn1-DNA and Zn2-DNA complexes, combined with mutational and structural analysis, indicate that a specialized region of the Zn1 domain is re-configured through the hydrophobic interaction with exposed nucleotide bases to initiate PARP-1 activation.

M Langelier; J Planck; S Roy; J Pascal

2011-12-31T23:59:59.000Z

273

Transgenic plants are sensitive bioindicators of nuclear pollution caused by the Chernobyl accident  

SciTech Connect (OSTI)

To evaluate the genetic consequences of radioactive contamination originating from the Nuclear reactor accident of Chernobyl on indigenous populations of plants and animals, it is essential to determine the rates of accumulating genetic changes in chronically irradiated populations. An increase in germline mutation rates in humans living close to the Chernobyl Nuclear Power Plant site, and a two- to tenfold increase in germline mutations in barn swallows breeding in Chernobyl have been reported. Little is known, however, about the effects of chronic irradiation on plant genomes. Ionizing radiation causes double-strand breaks in DNA, which are repaired via illegitimate or homologous recombination. The authors make use of Arabidopsis thaliana plants carrying a {beta}-glucuronidase marker gene as a recombination substrate to monitor genetic alterations in plant populations, which are caused by nuclear pollution of the environment around Chernobyl. A significant increase in somatic intrachromosomal recombination frequencies was observed at nuclear pollution levels from 0.1--900 Ci/km{sup 2}, consistent with an increase in chromosomal aberrations. This bioindicator may serve as a convenient and ethically acceptable alternative to animal systems.

Kovalchuk, I.; Kovalchuk, O. [Ivano-Frankivsk State Medical Academy (Ukraine)]|[Friedrich Miescher Inst., Basel (Switzerland); Arkhipov, A. [Chernobyl Scientific and Technical Center of International Research (Ukraine); Hohn, B. [Friedrich Miescher Inst., Basel (Switzerland)

1998-11-01T23:59:59.000Z

274

A Symmetry Breaking Model for X Chromosome Inactivation  

E-Print Network [OSTI]

In mammals, dosage compensation of X linked genes in female cells is achieved by inactivation of one of their two X chromosomes which is randomly chosen. The earliest steps in X-inactivation (XCI), namely the mechanism whereby cells count their X chromosomes and choose between two equivalent X, remain mysterious. Starting from the recent discovery of X chromosome colocalization at the onset of X-inactivation, we propose a Statistical Mechanics model of XCI, which is investigated by computer simulations and checked against experimental data. Our model describes how a `blocking factor' complex is self-assembled and why only one is formed out of many diffusible molecules, resulting in a spontaneous symmetry breaking (SB) in the binding to two identical chromosomes. These results are used to derive a scenario of biological implications describing all current experimental evidences, e.g., the importance of colocalization.

M. Nicodemi; A. Prisco

2008-01-17T23:59:59.000Z

275

Radiative PQ Breaking and the Higgs Boson Mass  

E-Print Network [OSTI]

The small and negative value of the Standard Model Higgs quartic coupling at high scales can be understood in terms of anthropic selection on a landscape where large and negative values are favored: most universes have a very short-lived electroweak vacuum and typical observers are in universes close to the corresponding metastability boundary. We provide a simple example of such a landscape with a Peccei-Quinn symmetry breaking scale generated through dimensional transmutation and supersymmetry softly broken at an intermediate scale. Large and negative contributions to the Higgs quartic are typically generated on integrating out the saxion field. Cancellations among these contributions are forced by the anthropic requirement of a sufficiently long-lived electroweak vacuum, determining the multiverse distribution for the Higgs quartic in a similar way to that of the cosmological constant. This leads to a statistical prediction of the Higgs boson mass that, for a wide range of parameters, yields the observed v...

D'Eramo, Francesco; Pappadopulo, Duccio

2015-01-01T23:59:59.000Z

276

Inertial blob-hole symmetry breaking in magnetised plasma filaments  

E-Print Network [OSTI]

Symmetry breaking between the propagation velocities of magnetised plasma filaments with large positive (blob) and negative (hole) amplitudes, as implied by a dimensional analysis scaling, is studied with global ("full-n") non-Boussinesq gyrofluid computations, which include finite inertia effects through nonlinear polarisation. Interchange blobs on a flat density background have higher inertia and propagate more slowly than holes. In the presence of a large enough density gradient, the effect is reversed: blobs accelerate down the gradient and holes are slowed in their propagation up the gradient. Drift wave blobs spread their initial vorticity rapidly into a fully developed turbulent state, whereas primary holes can remain coherent for many eddy turnover times. The results bear implications for plasma edge zonal flow evolution and tokamak scrape-off-layer transport.

Kendl, Alexander

2015-01-01T23:59:59.000Z

277

Laser engineered net shaping (LENS) for the repair and modification of NWC metal components.  

SciTech Connect (OSTI)

Laser Engineered Net Shaping{trademark} (LENS{reg_sign}) is a layer additive manufacturing process that creates fully dense metal components using a laser, metal powder, and a computer solid model. This process has previously been utilized in research settings to create metal components and new material alloys. The ''Qualification of LENS for the Repair and Modification of Metal NWC Components'' project team has completed a Technology Investment project to investigate the use of LENS for repair of high rigor components. The team submitted components from four NWC sites for repair or modification using the LENS process. These components were then evaluated for their compatibility to high rigor weapons applications. The repairs included hole filling, replacement of weld lips, addition of step joints, and repair of surface flaws and gouges. The parts were evaluated for mechanical properties, corrosion resistance, weldability, and hydrogen compatibility. This document is a record of the LENS processing of each of these component types and includes process parameters, build strategies, and lessons learned. Through this project, the LENS process was shown to successfully repair or modify metal NWC components.

Atwood, Clinton J.; Smugeresky, John E. (Sandia National Labs, Livermore,CA); Gill, David Dennis

2006-11-01T23:59:59.000Z

278

Remote Welding, NDE and Repair of DOE Standardized Canisters  

SciTech Connect (OSTI)

The U.S. Department of Energy (DOE) created the National Spent Nuclear Fuel Program (NSNFP) to manage DOE’s spent nuclear fuel (SNF). One of the NSNFP’s tasks is to prepare spent nuclear fuel for storage, transportation, and disposal at the national repository. As part of this effort, the NSNFP developed a standardized canister for interim storage and transportation of SNF. These canisters will be built and sealed to American Society of Mechanical Engineers (ASME) Section III, Division 3 requirements. Packaging SNF usually is a three-step process: canister loading, closure welding, and closure weld verification. After loading SNF into the canisters, the canisters must be seal welded and the welds verified using a combination of visual, surface eddy current, and ultrasonic inspection or examination techniques. If unacceptable defects in the weld are detected, the defective sections of weld must be removed, re-welded, and re-inspected. Due to the high contamination and/or radiation fields involved with this process, all of these functions must be performed remotely in a hot cell. The prototype apparatus to perform these functions is a floor-mounted carousel that encircles the loaded canister; three stations perform the functions of welding, inspecting, and repairing the seal welds. A welding operator monitors and controls these functions remotely via a workstation located outside the hot cell. The discussion describes the hardware and software that have been developed and the results of testing that has been done to date.

Eric Larsen; Art Watkins; Timothy R. McJunkin; Dave Pace; Rodney Bitsoi

2006-05-01T23:59:59.000Z

279

In situ repair of a failed compression fitting  

DOE Patents [OSTI]

A method and apparatus for the in situ repair of a failed compression fitting is provided. Initially, a portion of a guide tube is inserted coaxially in the bore of the compression fitting and locked therein. A close fit dethreading device is then coaxially mounted on the guide tube to cut the threads from the fitting. Thereafter, the dethreading device and guide tube are removed and a new fitting is inserted onto the dethreaded fitting with the body of the new fitting overlaying the dethreaded portion. Finally, the main body of the new fitting is welded to the main body of the old fitting whereby a new threaded portion of the replacement fitting is precisely coaxial with the old threaded portion. If needed, a bushing is located on the dethreaded portion which is sized to fit snugly between the dethreaded portion and the new fitting. Preferably, the dethreading device includes a cutting tool which is moved incrementally in a radial direction whereby the threads are cut from the threaded portion of the failed fitting in increments.

Wolbert, R.R.; Jandrasits, W.G.

1985-08-05T23:59:59.000Z

280

In situ repair of a failed compression fitting  

DOE Patents [OSTI]

A method and apparatus for the in situ repair of a failed compression fitg is provided. Initially, a portion of a guide tube is inserted coaxially in the bore of the compression fitting and locked therein. A close fit dethreading device is then coaxially mounted on the guide tube to cut the threads from the fitting. Thereafter, the dethreading device and guide tube are removed and a new fitting is inserted onto the dethreaded fitting with the body of the new fitting overlaying the dethreaded portion. Finally, the main body of the new fitting is welded to the main body of the old fitting whereby a new threaded portion of the replacement fitting is precisely coaxial with the old threaded portion. If needed, a bushing is located on the dethreaded portion which is sized to fit snugly between the dethreaded portion and the new fitting. Preferably, the dethreading device includes a cutting tool which is moved incrementally in a radial direction whereby the threads are cut from the threaded portion of the failed fitting in increments.

Wolbert, Ronald R. (McKees Rocks, PA); Jandrasits, Walter G. (Pittsburgh, PA)

1986-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

INTERNAL REPAIR OF GAS PIPLINES SURVEY OF OPERATOR EXPERIENCE AND INDUSTRY NEEDS REPORT  

SciTech Connect (OSTI)

A repair method that can be applied from the inside of a gas transmission pipeline (i.e., a trenchless repair) is an attractive alternative to conventional repair methods since the need to excavate the pipeline is precluded. This is particularly true for pipelines in environmentally sensitive and highly populated areas. The objectives of the project are to evaluate, develop, demonstrate, and validate internal repair methods for pipelines; develop a functional specification for an internal pipeline repair system; and prepare a recommended practice for internal repair of pipelines. The purpose of this survey is to better understand the needs and performance requirements of the natural gas transmission industry regarding internal repair. A total of fifty-six surveys were sent to pipeline operators. A total of twenty completed surveys were returned, representing a 36% response rate, which is considered very good given the fact that tailored surveys are known in the marketing industry to seldom attract more than a 10% response rate. The twenty survey responses produced the following principal conclusions: (1) Use of internal weld repair is most attractive for river crossings, under other bodies of water (e.g., lakes and swamps) in difficult soil conditions, under highways, under congested intersections, and under railway crossings. All these areas tend to be very difficult and very costly if, and where, conventional excavated repairs may be currently used. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling (HDD) when a new bore must be created to solve a leak or other problem in a water/river crossing. (3) The typical travel distances required can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). In concept, these groups require pig-based systems; despooled umbilical systems could be considered for the first two groups. For the last group a self-propelled system with an onboard self-contained power and welding system is required. (4) Pipe size range requirements range from 50.8 mm (2 in.) through 1,219.2 mm (48 in.) in diameter. The most common size range for 80% to 90% of operators surveyed is 508 mm to 762 mm (20 in. to 30 in.) diameter, with 95% using 558.8 mm (22 in.) diameter pipe.

Ian D. Harris

2003-09-01T23:59:59.000Z

282

Development of bonded composite doublers for the repair of oil recovery equipment.  

SciTech Connect (OSTI)

An unavoidable by-product of a metallic structure's use is the appearance of crack and corrosion flaws. Economic barriers to the replacement of these structures have created an aging infrastructure and placed even greater demands on efficient and safe repair methods. In the past decade, an advanced composite repair technology has made great strides in commercial aviation use. Extensive testing and analysis, through joint programs between the Sandia Labs FAA Airworthiness Assurance Center and the aviation industry, have proven that composite materials can be used to repair damaged aluminum structure. Successful pilot programs have produced flight performance history to establish the durability of bonded composite patches as a permanent repair on commercial aircraft structures. With this foundation in place, this effort is adapting bonded composite repair technology to civil structures. The use of bonded composite doublers has the potential to correct the difficulties associated with current repair techniques and the ability to be applied where there are no rehabilitation options. It promises to be cost-effective with minimal disruption to the users of the structure. This report concludes a study into the application of composite patches on thick steel structures typically used in mining operations. Extreme fatigue, temperature, erosive, and corrosive environments induce an array of equipment damage. The current weld repair techniques for these structures provide a fatigue life that is inferior to that of the original plate. Subsequent cracking must be revisited on a regular basis. The use of composite doublers, which do not have brittle fracture problems such as those inherent in welds, can help extend the structure's fatigue life and reduce the equipment downtime. Two of the main issues for adapting aircraft composite repairs to civil applications are developing an installation technique for carbon steel and accommodating large repairs on extremely thick structures. This study developed and proved an optimum field installation process using specific mechanical and chemical surface preparation techniques coupled with unique, in-situ heating methods. In addition, a comprehensive performance assessment of composite doubler repairs was completed to establish the viability of this technology for large, steel structures. The factors influencing the durability of composite patches in severe field environments were evaluated along with related laminate design issues.

Roach, David W.; Rackow, Kirk A.

2005-06-01T23:59:59.000Z

283

Design Considerations for Monopile Founded Offshore Wind Turbines Subject to Breaking Waves  

E-Print Network [OSTI]

DESIGN CONSIDERATIONS FOR MONOPILE FOUNDED OFFSHORE WIND TURBINES SUBJECT TO BREAKING WAVES A Thesis by GARRETT REESE OWENS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... Farms ...... 4 Figure 2 Overview of Offshore Wind Turbine Terminology................................. 7 Figure 3 Overturning Moment as a Function of Water Depth ............................... 10 Figure 4 Types of Breaking Waves...

Owens, Garrett Reese 1987-

2012-11-26T23:59:59.000Z

284

Symmetry Breaking in Graphene Gregory S. Boebinger, National High Magnetic Field Laboratory  

E-Print Network [OSTI]

Symmetry Breaking in Graphene Gregory S. Boebinger, National High Magnetic Field Laboratory DMR. In this experiment, Landau levels in graphene were used to study the breaking of SU(4) symmetry--a higher dimensional states by their spin polarization. It was found that graphene turns into either a spin ferromagnet

Weston, Ken

285

Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities  

SciTech Connect (OSTI)

Grid parity--or break-even cost--for photovoltaic (PV) technology is defined as the point where the cost of PV-generated electricity equals the cost of electricity purchased from the grid. Break-even cost is expressed in $/W of an installed system. Achieving break-even cost is a function of many variables. Consequently, break-even costs vary by location and time for a country, such as the United States, with a diverse set of resources, electricity prices, and other variables. In this report, we analyze PV break-even costs for U.S. residential customers. We evaluate some key drivers of grid parity both regionally and over time. We also examine the impact of moving from flat to time-of-use (TOU) rates, and we evaluate individual components of the break-even cost, including effect of rate structure and various incentives. Finally, we examine how PV markets might evolve on a regional basis considering the sensitivity of the break-even cost to four major drivers: technical performance, financing parameters, electricity prices and rates, and policies. We find that local incentives rather than ?technical? parameters are in general the key drivers of the break-even cost of PV. Additionally, this analysis provides insight about the potential viability of PV markets.

Denholm, P.; Margolis, R. M.; Ong, S.; Roberts, B.

2009-12-01T23:59:59.000Z

286

Generation, propagation, and breaking of an internal wave beam Heather A. Clark and Bruce R. Sutherlanda  

E-Print Network [OSTI]

Generation, propagation, and breaking of an internal wave beam Heather A. Clark and Bruce R fluids support the propagation of inter- nal gravity waves that arise from buoyancy restoring forces non- local effect on the mean flow through the propagation and breaking of internal waves. While

Sutherland, Bruce

287

Hydrogen bond breaking probed with multidimensional stimulated vibrational echo correlation spectroscopy  

E-Print Network [OSTI]

Hydrogen bond breaking probed with multidimensional stimulated vibrational echo correlation September 2003 Hydrogen bond population dynamics are extricated with exceptional detail using ultrafast ( 50 of methanol­OD oligomers in CCl4 . Hydrogen bond breaking makes it possible to acquire data for times much

Fayer, Michael D.

288

Formation of beads-on-a-string structures during break-up of viscoelastic filaments  

E-Print Network [OSTI]

Break-up of viscoelastic filaments is pervasive in both nature and technology. If a filament is formed by placing a drop of saliva between a thumb and forefinger and is stretched, the filament’s morphology close to break-up ...

Bhat, Pardeep P.

289

Physical Naturalness and Dynamical Breaking of Classical Scale Invariance  

E-Print Network [OSTI]

We propose a model of a confining dark sector, dark technicolor, that communicates with the Standard Model through the Higgs portal. In this model electroweak symmetry breaking and dark matter share a common origin, and the electroweak scale is generated dynamically. Our motivation to suggest this model is the absense of evidence for new physics from recent LHC data. Although the conclusion is far from certain at this point, this lack of evidence may suggest that no mechanism exists at the electroweak scale to stabilise the Higgs mass against radiative corrections from UV physics. The usual reaction to this puzzling situation is to conclude that the stabilising new physics is either hidden from us by accident, or that it appears at energies that are currently inaccessible, such that nature is indeed fine-tuned. In order to re-examine the arguments that have lead to this dichotomy, we review the concept of naturalness in effective field theories, discussing in particular the role of quadratic divergences in relation to different energy scales. This leads us to suggest classical scale invariance as a guidline for model building, implying that explicit mass scales are absent in the underlying theory.

Matti Heikinheimo; Antonio Racioppi; Martti Raidal; Christian Spethmann; Kimmo Tuominen

2014-05-05T23:59:59.000Z

290

Natural cold baryogenesis from strongly interacting electroweak symmetry breaking  

SciTech Connect (OSTI)

The mechanism of ''cold electroweak baryogenesis'' has been so far unpopular because its proposal has relied on the ad-hoc assumption of a period of hybrid inflation at the electroweak scale with the Higgs acting as the waterfall field. We argue here that cold baryogenesis can be naturally realized without the need to introduce any slow-roll potential. Our point is that composite Higgs models where electroweak symmetry breaking arises via a strongly first-order phase transition provide a well-motivated framework for cold baryogenesis. In this case, reheating proceeds by bubble collisions and we argue that this can induce changes in Chern-Simons number, which in the presence of new sources of CP violation commonly lead to baryogenesis. We illustrate this mechanism using as a source of CP violation an effective dimension-six operator which is free from EDM constraints, another advantage of cold baryogenesis compared to the standard theory of electroweak baryogenesis. Our results are general as they do not rely on any particular UV completion but only on a stage of supercooling ended by a first-order phase transition in the evolution of the universe, which can be natural if there is nearly conformal dynamics at the TeV scale. Besides, baryon-number violation originates from the Standard Model only.

Konstandin, Thomas; Servant, Géraldine, E-mail: tkonstan@cern.ch, E-mail: geraldine.servant@cern.ch [CERN Physics Department, Theory Division, CH-1211 Geneva 23 (Switzerland)

2011-07-01T23:59:59.000Z

291

Sea quark transverse momentum distributions and dynamical chiral symmetry breaking  

SciTech Connect (OSTI)

Recent theoretical studies have provided new insight into the intrinsic transverse momentum distributions of valence and sea quarks in the nucleon at a low scale. The valence quark transverse momentum distributions (q - qbar) are governed by the nucleon's inverse hadronic size R{sup -1} ~ 0.2 GeV and drop steeply at large p{sub T}. The sea quark distributions (qbar) are in large part generated by non-perturbative chiral-symmetry breaking interactions and extend up to the scale rho{sup -1} ~ 0.6 GeV. These findings have many implications for modeling the initial conditions of perturbative QCD evolution of TMD distributions (starting scale, shape of p{sub T}. distributions, coordinate-space correlation functions). The qualitative difference between valence and sea quark intrinsic p{sub T}. distributions could be observed experimentally, by comparing the transverse momentum distributions of selected hadrons in semi-inclusive deep-inelastic scattering, or those of dileptons produced in pp and pbar-p scattering.

Schweitzer, Peter [Univ. of Connecticut, Storrs, CT (United States); Strikman, Mark [Penn State Univ., State College, PA (United States); Weiss, Christian [JLAB Newport News, VA (United States)

2014-01-01T23:59:59.000Z

292

Breaking FIR-Radio Correlation: The Case of Interacting Galaxies  

E-Print Network [OSTI]

Far-infrared (FIR)--radio correlation is a well-established empirical connection between continuum radio and dust emission of star-forming galaxies, used as a tool in determining star-formation rates. Here we point out that in the case of interacting star-forming galaxies this tool might break. Galactic interactions and mergers have been known to give rise to tidal shocks and disrupt morphologies especially in the smaller of the interacting components. Moreover, these shocks can also heat the gas and dust and accelerate particles leading to tidal cosmic-ray population in addition to standard galactic cosmic rays. Both heating and additional non-thermal radiation will obviously affect the FIR-radio correlation of these systems. To test this hypothesis we have analyzed a sample of 43 infrared bright star-forming interacting galaxies at different merger stages. We have found that their FIR-radio correlation parameter and radio emission spectral index vary over different merger stages and behave as it would be ex...

Donevski, Darko

2015-01-01T23:59:59.000Z

293

Automated inspection of surface breaking cracks using GMR sensor arrays  

SciTech Connect (OSTI)

We present a prototype for automated magnetic stray field testing of ferromagnetic roller bearings. For this purpose NDE-adapted GMR sensor arrays (giant magneto resistance) are used for the detection of surface breaking cracks. The sensors are miniaturized down to the lower ?m-regime to achieve adequate spatial resolution. In doing so, sensor arrays with up to 48 elements are used to inspect the bearing surface within a few seconds only. In contrast to magnetic particle inspection (MPI), where the global magnetization requires a further inspection step and succeeding demagnetization, the presented prototype only locally magnetize the surface area in the vicinity of the GMR Sensors. For the local magnetization, the applied sub-surface magnetic field was simulated and proofed for detecting flaws with a depth of a few 10 ?m. By multiplexing the sensor array with an adapted read out electronics we quasi simultaneously detect the normal field component of about 100?m above the surface. The detection of artificial notches with a depth of 40 ?m and more could be resolved with a SNR better than 20 dB. The presented testing facility is fast and provides a step towards automated testing of safety relevant steel components.

Pelkner, Matthias; Reimund, Verena; Erthner, Thomas; Panke, Nicolai; Kreutzbruck, Marc [BAM Federal Institute for Material Research and Testing, Unter den Eichen 87, 12205 Berlin (Germany)

2014-02-18T23:59:59.000Z

294

Scales of Fermion Mass Generation and Electroweak Symmetry Breaking  

E-Print Network [OSTI]

The scale of mass generation for fermions (including neutrinos) and the scale for electroweak symmetry breaking (EWSB) can be bounded from above by the unitarity of scattering involving longitudinal weak gauge bosons or their corresponding would-be Goldstone bosons. Including the exact n-body phase space we analyze the 2 --> n ($n \\geq 2$) processes for the fermion-(anti)fermion scattering into multiple gauge boson final states. Contrary to naive energy power counting, we demonstrate that as $n$ becomes large, the competition between an increasing energy factor and a phase-space suppression leads to a {\\it strong new upper bound} on the scale of fermion mass generation at a finite value $n=n_s$, which is {\\it independent of the EWSB scale,} $v = (\\sqrt{2}G_F)^{-1/2}$. For quarks, leptons and Majorana neutrinos, the strongest 2 --> n limits range from about 3TeV to 130-170TeV (with $2\\lesssim n_s \\lesssim 24$), depending on the measured fermion masses. Strikingly, given the tiny neutrino masses as constrained by the neutrino oscillations, neutrinoless double-beta decays and astrophysical observations, the unitarity violation of $\

Duane A. Dicus; Hong-Jian He

2005-06-11T23:59:59.000Z

295

Treatment methods for breaking certain oil and water emulsions  

DOE Patents [OSTI]

Disclosed are treatment methods for breaking emulsions of petroleum oil and salt water, fatty oil and water, and those resulting from liquefication of organic material. The emulsions are broken by heating to a predetermined temperature at or above about 200.degree. C. and pressurizing to a predetermined pressure above the vapor pressure of water at the predetermined temperature to produce a heated and pressurized fluid. The heated and pressurized fluid is contained in a single vessel at the predetermined temperature and pressure for a predetermined period of time to effectively separate the emulsion into substantially distinct first and second phases, the first phase comprising primarily the petroleum oil, the second phase comprising primarily the water. The first and second phases are separately withdrawn from the vessel at a withdraw temperature between about 200.degree. C. and 374.degree. C. and a withdraw pressure above the vapor pressure of water at the withdraw temperature. Where solids are present in the certain emulsions, the above described treatment may also effectively separate the certain emulsion into a substantially distinct third phase comprising primarily the solids.

Sealock, Jr., L. John (W. Richland, WA); Baker, Eddie G. (Richland, WA); Elliott, Douglas C. (Richland, WA)

1992-01-01T23:59:59.000Z

296

Spontaneous symmetry breaking in Schroedinger lattices with two nonlinear sites  

SciTech Connect (OSTI)

We introduce discrete systems in the form of straight (infinite) and ring-shaped chains, with two symmetrically placed nonlinear sites. The systems can be implemented in nonlinear optics (as waveguiding arrays) and Bose-Einstein condensates (by means of an optical lattice). A full set of exact analytical solutions for symmetric, asymmetric, and antisymmetric localized modes is found, and their stability is investigated in a numerical form. The symmetry-breaking bifurcation, through which the asymmetric modes emerge from the symmetric ones, is found to be of the subcritical type. It is transformed into a supercritical bifurcation if the nonlinearity is localized in relatively broad domains around two central sites, and also in the ring of a small size, i.e., in effectively nonlocal settings. The family of antisymmetric modes does not undergo bifurcations and features both stable and unstable portions. The evolution of unstable localized modes is investigated by means of direct simulations. In particular, unstable asymmetric states, which exist in the case of the subcritical bifurcation, give rise to breathers oscillating between the nonlinear sites, thus restoring an effective dynamical symmetry between them.

Brazhnyi, Valeriy A.; Malomed, Boris A. [Centro de Fisica do Porto, Faculdade de Ciencias, Universidade do Porto, R. Campo Alegre 687, Porto 4169-007 (Portugal); ICFO-Institut de Ciencies Fotoniques, Universitat Politecnica de Catalunya, Mediterranean Technology Park, 08860 Castelldefels (Barcelona) (Spain) and Department of Physical Electronics, School of Electrical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978 (Israel)

2011-05-15T23:59:59.000Z

297

Automatic coke oven heating control system at Burns Harbor for normal and repair operation  

SciTech Connect (OSTI)

An automatic heating control system for coke oven batteries was developed in 1985 for the Burns Harbor No. 1 battery and reported in the 1989 Ironmaking Conference Proceedings. The original system was designed to maintain a target coke temperature at a given production level under normal operating conditions. Since 1989, enhancements have been made to this control system so that it can also control the battery heating when the battery is under repair. The new control system has improved heating control capability because it adjusts the heat input to the battery in response to anticipated changes in the production schedule. During a recent repair of this 82 oven battery, the pushing schedule changed from 102 ovens/day to 88 ovens/day, then back to 102 ovens/day, then to 107 ovens/day. During this repair, the control system was able to maintain the coke temperature average standard deviation at 44 F, with a maximum 75 F.

Battle, E.T.; Chen, K.L. [Bethlehem Steel Corp., Burns Harbor, IN (United States); [Bethlehem Steel Corp., PA (United States)

1997-12-31T23:59:59.000Z

298

Evaluation of bisphenol E cyanate ester for the resin-injection repair of advanced composites  

SciTech Connect (OSTI)

This thesis is a compilation of a general introduction and literature review that ties together the subsequent chapters which consist of two journal articles that have yet to be submitted for publication. The overall topic relates to the evaluation and application of a new class of cyanate ester resin with unique properties that lend it applicable to use as a resin for injection repair of high glass transition temperature polymer matrix composites. The first article (Chapter 2) details the evaluation and optimization of adhesive properties of this cyanate ester and alumina nanocomposites under different conditions. The second article (Chapter 3) describes the development and evaluation of an injection repair system for repairing delaminations in polymer matrix composites.

Wilber Yaote Lio

2009-12-19T23:59:59.000Z

299

A survey of repair practices for nuclear power plant containment metallic pressure boundaries  

SciTech Connect (OSTI)

The Nuclear Regulatory Commission has initiated a program at the Oak Ridge National Laboratory to provide assistance in their assessment of the effects of potential degradation on the structural integrity and leaktightness of metal containment vessels and steel liners of concrete containments in nuclear power plants. One of the program objectives is to identify repair practices for restoring metallic containment pressure boundary components that have been damaged or degraded in service. This report presents issues associated with inservice condition assessments and continued service evaluations and identifies the rules and requirements for the repair and replacement of nonconforming containment pressure boundary components by welding or metal removal. Discussion topics include base and welding materials, welding procedure and performance qualifications, inspection techniques, testing methods, acceptance criteria, and documentation requirements necessary for making acceptable repairs and replacements so that the plant can be returned to a safe operating condition.

Oland, C.B.; Naus, D.J. [Oak Ridge National Lab., TN (United States)

1998-05-01T23:59:59.000Z

300

ADVANCES IN ATMOSPHERIC SCIENCES, VOL. 26, NO. 4, 2009, 701706 Variability of Northeast China River Break-up Date  

E-Print Network [OSTI]

River Break-up Date WANG Huijun1,2 ( ¡) and SUN Jianqi1,2 (ê ) 1 Institute of Atmospheric Physics investigates the variability of the break-up dates of the rivers in Northeast China from their icebound states for the period of 1957­2005 and explores some potential explanatory mechanisms. Results show that the break-up

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Bosh repairs No. 3 blast furnace, Edgar Thomson Plant Mon Valley Works  

SciTech Connect (OSTI)

The paper describes in detail the steps taken from quenching to dry out of the furnace to repair the bosh area of the No.3 blast furnace. Inspection of the area revealed that there was no brick anywhere in the bosh. Brick in the tuyere breast area had been peeled back to reveal the steel plate, and descaling revealed 14 pipes fully exposed. None were leaking, but one seemed badly deteriorated. Conventional repairs could not take place before the scheduled blow-in. Installation of coolers were instead tried.

Stoupis, M.G.

1993-01-01T23:59:59.000Z

302

EVALUATION OF A UAV COMPOSITE WING SPAR REPAIR USING AN EMBEDDED OPTICAL FIBER RAYLEIGH BACK-SCATTERING DISTRIBUTED STRAIN SENSING  

E-Print Network [OSTI]

EVALUATION OF A UAV COMPOSITE WING SPAR REPAIR USING AN EMBEDDED OPTICAL FIBER RAYLEIGH BACK Branch, Tel-Aviv Israel ikressel@iai.co.il ABSTRACT A representing damaged UAV wing spar cap was repaired requirements for UAVs, where the substantiation of structural bonded joint can be based on: "repeatable

Paris-Sud XI, Université de

303

The Role of Nucleotide Excision Repair in Restoring Replication Following UV-Induced Damage in Escherichia coli  

E-Print Network [OSTI]

The Role of Nucleotide Excision Repair in Restoring Replication Following UV-Induced Damage DNA synthesis in the absence of nucleotide excision repair does not promote cell survivalA mutants....................... 26 Following low doses of UV irradiation cells lacking nucleotide excision

Courcelle, Justin

304

Dietary fish oil and butyrate increase apoptosis and decrease aberrant crypt foci in colon cancer by enhancing histone acetylation and p21waf1/cip1 expression  

E-Print Network [OSTI]

shrinkage, mitochondrial membrane blebbing, nuclear degradation, and DNA fragmentation (Shanmugathasan and Jothy, 2000). As the DNA fragments, the remaining double-strand breaks can be identified by gel electrophoresis, producing a specific pattern..., the nuclear chromatin condenses and DNA is degraded. Cellular remnants are packaged into apoptotic bodies, which are then phagocytized or sloughed into the passing lumenal contents (Vaux and Strasser, 1996). p21Waf1/Cip1 One of the earliest events...

Covert, Kristy Lynn

2006-08-16T23:59:59.000Z

305

Hot repair of ceramic burner on hot blast stoves at USS/Kobe`s {number_sign}3 blast furnace  

SciTech Connect (OSTI)

During the 1992 reline of the No. 3 blast furnace, three new stoves were constructed. The design of the stoves, equipped with internal ceramic burners, was for providing a hot blast temperature of 2,000 F at a wind rate of 140,000 SCFM. After 3 years the performance had deteriorated so the burners were cleaned. When a second cleaning did not improve the performance of No. 3 blast furnace, it was decided to repair the refractory while still hot. The paper describes the hot repair procedures, taking a stove off for repairs, maintenance heat up during repairs, two stove operation, stove commissioning, repair of a ceramic burner, and wet gas prevention.

Bernarding, T.F.; Chemorov, M.; Shimono, S.; Phillips, G.R.

1997-12-31T23:59:59.000Z

306

Physics and learning based computational models for breaking bow waves based on new boundary immersion approaches  

E-Print Network [OSTI]

A ship moving on the free surface produces energetic breaking bow waves which generate spray and air entrainment. Present experimental, analytic, and numerical studies of this problem are costly, inaccurate and not robust. ...

Weymouth, Gabriel David

2008-01-01T23:59:59.000Z

307

Electroweak symmetry breaking in the era of the Higgs boson discovery  

E-Print Network [OSTI]

In this thesis we study possible deviations from the electroweak symmetry breaking mechanism as predicted by the Standard Model (SM), and we introduce a new framework to analyze hadronic final states at colliders. In the ...

Bertolini, Daniele, Ph. D. Massachusetts Institute of Technology

2014-01-01T23:59:59.000Z

308

Introduction of Break-Out Session at the International PV Module Quality Assurance Forum (Presentation)  

SciTech Connect (OSTI)

This presentation outlines review requirements for quality assurance (QA) rating systems, logical design of QA systems, and specific tasks for break-out session 1 of the 2011 International PV Module Quality Assurance Forum.

Kurtz, S.; Wohlgemuth, J.; Yamamichi, M.; Sample, T.

2011-07-01T23:59:59.000Z

309

Double Ended Guillotine Break in a Prismatic Block VHTR Lower Plenum Air Ingress Scenario  

E-Print Network [OSTI]

The double ended guillotine break leading to density-driven air ingress has been identified as a low probability yet high consequence event for Very High Temperature Reactor (VHTR). The lower plenum of the VHTR contains the core support structure...

Hartley, Jessica

2012-10-19T23:59:59.000Z

310

E-Print Network 3.0 - anomaly-mediated supersymmetry breaking...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

; Physics 58 arXiv:hep-ph0103095v19Mar2001 Low-Energy Supersymmetry and its Phenomenology Summary: . This approach has been called anomaly-mediated SUSY-breaking (AMSB)....

311

Spring Break Course in Florida! Forensic entomology is a branch of forensic sci-  

E-Print Network [OSTI]

Spring Break Course in Florida! Forensic entomology is a branch of forensic sci- ence utilizing the science of forensic en- tomology through daily laboratory and field ac- tivities. We also interact

312

Simulation of a small break loss of coolant accident conducted at the BETHSY Integral Test Facility  

E-Print Network [OSTI]

. The computer code RELAP5/MOD3 was used to model the BETHSY Integral Test Facility for a. small break loss of coolant accident. This transient simulates a 2 inch cold leg break without high pressure safety injection, following the conditions of International..., and general input to my gra, duate education. TABLE OF CONTENTS CHAPTER Page I INTRODUCTION I. 1 Need for Investigation I. 2 Computational Modeling . I. 3 Experimental Modeling I, 4 International Cooperation . 1 3 RELAP5 CODE DESCRIPTION II. 1...

Bott, Charles Patrick

1992-01-01T23:59:59.000Z

313

DNA repair efficiency in germ cells and early mouse embryos and consequences for radiation-induced transgenerational genomic damage  

SciTech Connect (OSTI)

Exposure to ionizing radiation and other environmental agents can affect the genomic integrity of germ cells and induce adverse health effects in the progeny. Efficient DNA repair during gametogenesis and the early embryonic cycles after fertilization is critical for preventing transmission of DNA damage to the progeny and relies on maternal factors stored in the egg before fertilization. The ability of the maternal repair machinery to repair DNA damage in both parental genomes in the fertilizing egg is especially crucial for the fertilizing male genome that has not experienced a DNA repair-competent cellular environment for several weeks prior to fertilization. During the DNA repair-deficient period of spermatogenesis, DNA lesions may accumulate in sperm and be carried into the egg where, if not properly repaired, could result in the formation of heritable chromosomal aberrations or mutations and associated birth defects. Studies with female mice deficient in specific DNA repair genes have shown that: (i) cell cycle checkpoints are activated in the fertilized egg by DNA damage carried by the sperm; and (ii) the maternal genotype plays a major role in determining the efficiency of repairing genomic lesions in the fertilizing sperm and directly affect the risk for abnormal reproductive outcomes. There is also growing evidence that implicates DNA damage carried by the fertilizing gamete as a mediator of postfertilization processes that contribute to genomic instability in subsequent generations. Transgenerational genomic instability most likely involves epigenetic mechanisms or error-prone DNA repair processes in the early embryo. Maternal and embryonic DNA repair processes during the early phases of mammalian embryonic development can have far reaching consequences for the genomic integrity and health of subsequent generations.

Marchetti, Francesco; Wyrobek, Andrew J.

2009-01-18T23:59:59.000Z

314

Latest advances in steam turbine design, blading, repairs, condition assessment, and condenser interaction  

SciTech Connect (OSTI)

This book contains papers presented at a conference on power generation. Topics covered include: a life extension approach for steam turbine blading in Electricite de France fossil plants, and on site 430 MW high pressure reheat turbine shell cracking and distortion repairs.

Rasmussen, D.M. (Turbine Consultants, Inc., Milwaukee, WI (US))

1989-01-01T23:59:59.000Z

315

Repair and Replacement projects help FM to honor its commitment to  

E-Print Network [OSTI]

of the University. Services provided fall into three major categories: preventive maintenance, routine repairs friendly power. Energy Management is continually recognized for the superior maintenance. · Maintenance (www.facm.umn. edu/services/maintenance.html) Maintenance Operations preserves the physical assets

Gulliver, Robert

316

Home Maintenance and Repair Owning a home is a major responsibility.  

E-Print Network [OSTI]

maintenance is conducted. Regular, preventive maintenance can pay off in peace of mind, utility cost savings, routine maintenance helps to prolong the life of the home and may prevent the need for major repairs of Benjamin Franklin, "An ounce of prevention is worth a pound of cure." Regular, routine maintenance enhances

317

Investigation of Corrosion Damage and Repair System in a Concrete Jetty Structure  

E-Print Network [OSTI]

Investigation of Corrosion Damage and Repair System in a Concrete Jetty Structure Farid Moradi of the deterioration was reinforcement corrosion, which initiated within few years after the completion of the jetty structure. The structure underwent major corrosion rehabilitation after 7 years of service. Despite the use

Mobasher, Barzin

318

Development/Plasticity/Repair A Structural MRI Study of Human Brain Development from  

E-Print Network [OSTI]

Development/Plasticity/Repair A Structural MRI Study of Human Brain Development from Birth to 2 Carolina, Chapel Hill, North Carolina 27599-7510 Brain development in the first 2 years after birth and schizophrenia. Knowledge regarding this period is currently quite limited. We studied structural brain

Utah, University of

319

Evaluation of temporary non-code repairs in safety class 3 piping systems  

SciTech Connect (OSTI)

Temporary non-ASME Code repairs in safety class 3 pipe and piping components are permissible during plant operation in accordance with Nuclear Regulatory Commission Generic Letter 90-05. However, regulatory acceptance of such repairs requires the licensee to undertake several timely actions. Consistent with the requirements of GL 90-05, this paper presents an overview of the detailed evaluation and relief request process. The technical criteria encompasses both ductile and brittle piping materials. It also lists appropriate evaluation methods that a utility engineer can select to perform a structural integrity assessment for design basis loading conditions to support the use of temporary non-Code repair for degraded piping components. Most use of temporary non-code repairs at a nuclear generating station is in the service water system which is an essential safety related system providing the ultimate heat sink for various plant systems. Depending on the plant siting, the service water system may use fresh water or salt water as the cooling medium. Various degradation mechanisms including general corrosion, erosion/corrosion, pitting, microbiological corrosion, galvanic corrosion, under-deposit corrosion or a combination thereof continually challenge the pressure boundary structural integrity. A good source for description of corrosion degradation in cooling water systems is provided in a cited reference.

Godha, P.C.; Kupinski, M.; Azevedo, N.F. [Northeast Utilities System, Hartford, CT (United States)

1996-12-01T23:59:59.000Z

320

Overview of NCHRP Design Guideline for EPS-Block Geofoam in Slope Stabilization and Repair  

E-Print Network [OSTI]

1 Overview of NCHRP Design Guideline for EPS-Block Geofoam in Slope Stabilization and Repair David in Construction Applications (EPS 2011 Norway) June 6-8, 2011 #12;2 ABSTRACT This paper presents an overview of the design guideline for the use of expanded polystyrene (EPS)-block geofoam for slope stabilization

Horvath, John S.

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Efficacy of Low Level Laser Therapy After Hand Flexor Tendon Repair  

SciTech Connect (OSTI)

Flexor tendon injury is a common problem requiring suturing repair followed by early postoperative mobilization. Muscle atrophy, joint stiffness, osteoarthritis, infection, skin necrosis, ulceration of joint cartilage and tendocutaneous adhesion are familiar complications produced by prolonged immobilization of surgically repaired tendon ruptures. The purpose of this study was to clarify the importance of low level laser therapy after hand flexor tendon repair in zone II. Thirty patients aging between 20 and 40 years were divided into two groups. Patients in group A (n = 15) received a conventional therapeutic exercise program while patients in group B (n = 15) received low level laser therapy combined with the same therapeutic exercise program. The results showed a statistically significant increase in total active motion of the proximal and distal interphalangeal joints as well as maximum hand grip strength at three weeks and three months postoperative, but improvement was more significant in group B. It was concluded that the combination of low level laser therapy and early therapeutic exercises was more effective than therapeutic exercises alone in improving total active motion of proximal and distal interphalangeal joints and hand grip strength after hand flexor tendon repair.

Ayad, K. E.; Abd El Mejeed, S. F. [Faculty of Physical Therapy, Cairo University (Egypt); El Gohary, H. M.; Abd Elrahman, M.; Bekheet, A. B. [Al Sahel Teaching Hospital, Cairo (Egypt)

2009-09-27T23:59:59.000Z

322

Multilayer sulfur-resistant composite metal membranes and methods of making and repairing the same  

DOE Patents [OSTI]

The invention relates to thin, hydrogen-permeable, sulfur-resistant membranes formed from multi-layers of palladium or palladium-alloy coatings on porous, ceramic or metal supports, methods of making these membranes, methods of repairing layers of these membranes and devices that incorporate these membranes.

Way, J. Douglas; Hatlevik, Oyvind

2014-07-15T23:59:59.000Z

323

Provably Repairing the ISO/IEC 9798 Standard for Entity Authentication  

E-Print Network [OSTI]

, or authentication of transmitted data [27,33]. The ISO (International Organization for Standardization) and IECProvably Repairing the ISO/IEC 9798 Standard for Entity Authentication David Basin, Cas Cremers the family of entity authentication protocols defined by the ISO/IEC 9798 standard and find numerous

Basin, David

324

Provably Repairing the ISO/IEC 9798 Standard for Entity Authentication  

E-Print Network [OSTI]

(International Organization for Standardization) and IEC (Interna- tional Electrotechnical Commission) jointlyProvably Repairing the ISO/IEC 9798 Standard for Entity Authentication David Basin, Cas Cremers the family of entity authentication proto- cols defined by the ISO/IEC 9798 standard and find numerous

Basin, David

325

Self-repairing Self-assembled Structures Daniel Arbuckle and Aristides A. G. Requicha  

E-Print Network [OSTI]

1 Self-repairing Self-assembled Structures Daniel Arbuckle and Aristides A. G. Requicha Department.arbuckle@usc.edu, requicha@usc.edu Abstract-- This paper introduces a method by which structures can be self-assembled from by a process analogous to mitosis. I. INTRODUCTION Self-assembly agents have the potential to become an im

Southern California, University of

326

Development/Plasticity/Repair Dendritic Spine Dynamics Regulate the Long-Term Stability  

E-Print Network [OSTI]

Development/Plasticity/Repair Dendritic Spine Dynamics Regulate the Long-Term Stability of Synaptic Plasticity Cian O'Donnell,1,2 Matthew F. Nolan,3 and Mark C. W. van Rossum1 1Institute for Adaptive of Edinburgh, Edinburgh EH8 9XD, United Kingdom Long-term synaptic plasticity requires postsynaptic influx

van Rossum, Mark

327

Development/Plasticity/Repair A Refractory Period for Rejuvenating GABAergic Synaptic  

E-Print Network [OSTI]

Development/Plasticity/Repair A Refractory Period for Rejuvenating GABAergic Synaptic Transmission and Ocular Dominance Plasticity with Dark Exposure Shiyong Huang,1* Yu Gu,2* Elizabeth M. Quinlan,2 Dark exposure initiated in adulthood reactivates robust ocular dominance plasticity in the visual

Gruner, Daniel S.

328

Development/Plasticity/Repair Simultaneous NMDA-Dependent Long-Term Potentiation of  

E-Print Network [OSTI]

Development/Plasticity/Repair Simultaneous NMDA-Dependent Long-Term Potentiation of EPSCs and Long activity-dependent long-term plasticity of neuronal networks is the interplay between excitatory, whereas a nitric oxide synthase inhibitor was ineffec- tive. Finally, network-induced plasticity

Segal, Menahem

329

Inspection, Assessment, and Repair of Grouted Ducts in Post-tensioned Bridge  

E-Print Network [OSTI]

and mitigation methods of voided ducts in PT structures. Although controversy exists on how to best protect PT tendons from corrosion, filling these voids with grout may be one option. An optimized grouting procedure for repairing these voids is needed how best...

Im, Seok Been

2011-02-22T23:59:59.000Z

330

Repairing and maintaining a public bicycle system: the case of Vlib' in Paris1  

E-Print Network [OSTI]

Repairing and maintaining a public bicycle system: the case of Vélib' in Paris1 . Martin Tironi Phd. Valued for their 'planet friendly' character, public bicycle systems have become the hallmark for cities to the worldwide spread of public bicycle schemes (PBS). They now exist in more than 110 cities around the world

Boyer, Edmond

331

Development/Plasticity/Repair Identification of Modulators of Hair Cell Regeneration in the  

E-Print Network [OSTI]

Development/Plasticity/Repair Identification of Modulators of Hair Cell Regeneration compounds that modulate hair cell regeneration in zebrafish. Of the 1680 compounds evaluated, we identified,aresyntheticglucocorticoidsthatpotentiatedhaircellnumbersduringregenerationandalsoinducedhair cell addition in the absence of damage. BrdU analysis confirmed that the extra hair cells arose from

Rubel, Edwin

332

Development/Plasticity/Repair Hair Cell Replacement in Adult Mouse Utricles after  

E-Print Network [OSTI]

Development/Plasticity/Repair Hair Cell Replacement in Adult Mouse Utricles after Targeted Ablation of Hair Cells with Diphtheria Toxin Justin S. Golub,1 Ling Tong,1 Tot B. Ngyuen,1 Cliff R. Hume,1 Richard developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse

Rubel, Edwin

333

Persistence of gamma-H2AX and 53BP1 foci in proliferating and nonproliferating human mammary epithelial cells after exposure to gamma-rays or iron ions  

SciTech Connect (OSTI)

To investigate {gamma}-H2AX (phosphorylated histone H2AX) and 53BP1 (tumour protein 53 binding protein No. 1) foci formation and removal in proliferating and non-proliferating human mammary epithelial cells (HMEC) after exposure to sparsely and densely ionizing radiation under different cell culture conditions. HMEC cells were grown either as monolayers (2D) or in extracellular matrix to allow the formation of acinar structures in vitro (3D). Foci numbers were quantified by image analysis at various time points after exposure. Our results reveal that in non-proliferating cells under 2D and 3D cell culture conditions, iron-ion induced {gamma}-H2AX foci were still present at 72 h after exposure, although 53BP1 foci returned to control levels at 48 h. In contrast in proliferating HMEC, both {gamma}-H2AX and 53BP1 foci decreased to control levels during the 24-48 h time interval after irradiation under 2D conditions. Foci numbers decreased faster after {gamma}-ray irradiation and returned to control levels by 12 h regardless of marker, cell proliferation status, and cell culture condition. Conclusions: The disappearance of radiation induced {gamma}-H2AX and 53BP1 foci in HMEC have different dynamics that depend on radiation quality and proliferation status. Notably, the general patterns do not depend on the cell culture condition (2D versus 3D). We speculate that the persistent {gamma}-H2AX foci in iron-ion irradiated non-proliferating cells could be due to limited availability of double strand break (DSB) repair pathways in G0/G1-phase, or that repair of complex DSB requires replication or chromatin remodeling.

Groesser, Torsten; Chang, Hang; Fontenay, Gerald; Chen, James; Costes, Sylvain V.; Barcellos-Hoff, Mary Helen; Parvin, Bahram; Rydberg, Bjorn

2010-12-22T23:59:59.000Z

334

The evolution of the break preclusion concept for nuclear power plants in Germany  

SciTech Connect (OSTI)

In the updating of the Guidelines for PWR`s of the {open_quotes}Reaktor-Sicherheitskommission{close_quotes} (RSK) in 1981 the requirements on the design have been changed with respect to the postulated leaks and breaks in the primary pressure boundary. The major change was a revision in the requirements for pipe whip protection. As a logical consequence of the {open_quotes}concept of basic safety{close_quotes} a guillotine type break or any other break type resulting in a large opening is not postulated any longer for the calculation of reaction and jet forces. As an upper limit for a leak an area of 0, 1 A (A = open cross section of the pipe) is postulated. This decision was based on a general assessment of the present PWR system design in Germany. Since then a number of piping systems have been requalified in the older nuclear power plants to comply with the break preclusion concept. Also a number of extensions of the concept have been developed to cover also leak-assumptions for branch pipes. Furthermore due considerations have been given to other aspects which could contribute to a leak development in the primary circuit, like vessel penetrations, manhole covers, flanges, etc. Now the break preclusion concept originally applied to the main piping has been developed into an integrated concept for the whole pressure boundary within the containment and will be applied also in the periodic safety review of present nuclear power plants.

Schulz, H. [Gesellschaft fuer Anlagen- und Reaktorsicherheit, Koeln (Germany)

1997-04-01T23:59:59.000Z

335

Effects of $?$-cluster breaking on 3$?$ cluster structures in $^{12}$C  

E-Print Network [OSTI]

To clarify the effects of $\\alpha$-cluster breaking on 3$\\alpha$ cluster structures in $^{12}$C, we investigate $^{12}$C using a hybrid model that combines the Brink-Bloch cluster model with the $p_{3/2}$ subshell closure wave function. We have found that $\\alpha$-cluster breaking caused by spin-orbit force significantly changes cluster structures of excited $0^{+}$ states through orthogonality to lower states. Spatially developed cluster components of the $0^{+}_{2}$ state are reduced. The $0^{+}_{3}$ state changes from a vibration mode in the bending motion of three $\\alpha$ clusters to a chain-like 3$\\alpha$ structure having an open triangle configuration. As a result of these structure changes of $0^{+}$ states, the band assignment for the $2^{+}_{2}$ state is changed by the $\\alpha$-cluster breaking effect. Namely, in model calculations without the $\\alpha$-cluster breaking effect, the $0^{+}_{2}$ state is assigned to be the band-head of the $2^{+}_{2}$ state. However, when we incorporate $\\alpha$-cluster breaking caused by the spin-orbit force, the $0^{+}_{3}$ state is regarded as the band-head of the $2^{+}_{2}$ state.

Tadahiro Suhara; Yoshiko Kanada-En'yo

2015-02-17T23:59:59.000Z

336

A novel role for the transcriptional modulator NusA in DNA repair/damage tolerance pathways in Escherichia coli  

E-Print Network [OSTI]

All organisms must contend with the consequences of DNA damage, induced by a variety of both endogenous and exogenous sources. Mechanisms of DNA repair and DNA damage tolerance are crucial for cellular survival after DNA ...

Cohen, Susan E., Ph. D. Massachusetts Institute of Technology

2009-01-01T23:59:59.000Z

337

UCSC EMPLOYEE HOUSING APARTMENTS APPLICATION Rental rates include: rent, refuse collection, common area utilities, groundskeeping services, and repairs and  

E-Print Network [OSTI]

area utilities, groundskeeping services, and repairs and maintenance of the Laureate Court complex. Tenants pay for their own utilities (i.e., electricity, gas, water, telephone and cable services). A $750

California at Santa Cruz, University of

338

Colorado State University Industrial Assessment Center Report CO0564 1 AR No. 1 -Repair Compressed Air Leaks  

E-Print Network [OSTI]

Colorado State University Industrial Assessment Center Report CO0564 1 AR No. 1 - Repair Compressed was then divided by 0.25 hours to convert the energy consumption into kW, so the #12;Colorado State University

339

Weld Repair of a Stamped Pressure Vessel in a Radiologically Controlled Zone  

SciTech Connect (OSTI)

In September 2012 an ASME B&PVC Section VIII stamped pressure vessel located at the DOE Hanford Site Effluent Treatment Facility (ETF) developed a through-wall leak. The vessel, a steam/brine heat exchanger, operated in a radiologically controlled zone (by the CH2MHill PRC or CHPRC), had been in service for approximately 17 years. The heat exchanger is part of a single train evaporator process and its failure caused the entire system to be shut down, significantly impacting facility operations. This paper describes the activities associated with failure characterization, technical decision making/planning for repair by welding, logistical challenges associated with performing work in a radiologically controlled zone, performing the repair, and administrative considerations related to ASME code requirements.

Cannell, Gary L. [Fluor Enterprises, Inc.; Huth, Ralph J. [CH2MHill Plateau Remediation Company; Hallum, Randall T. [Fluor Government Group

2013-08-26T23:59:59.000Z

340

Subterranean barriers, methods, and apparatuses for forming, inspecting, selectively heating, and repairing same  

DOE Patents [OSTI]

A subterranean barrier and method for forming same are disclosed, the barrier including a plurality of casing strings wherein at least one casing string of the plurality of casing strings may be affixed to at least another adjacent casing string of the plurality of casing strings through at least one weld, at least one adhesive joint, or both. A method and system for nondestructively inspecting a subterranean barrier is disclosed. For instance, a radiographic signal may be emitted from within a casing string toward an adjacent casing string and the radiographic signal may be detected from within the adjacent casing string. A method of repairing a barrier including removing at least a portion of a casing string and welding a repair element within the casing string is disclosed. A method of selectively heating at least one casing string forming at least a portion of a subterranean barrier is disclosed.

Nickelson, Reva A. (Shelley, ID); Sloan, Paul A. (Rigby, ID); Richardson, John G. (Idaho Falls, ID); Walsh, Stephanie (Idaho Falls, ID); Kostelnik, Kevin M. (Idaho, ID)

2009-04-07T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Template strand scrunching during DNA gap repair synthesis by human polymerase [lamda  

SciTech Connect (OSTI)

Family X polymerases such as DNA polymerase {lambda}(Pol {lambda}) are well suited for filling short gaps during DNA repair because they simultaneously bind both the 5{prime} and 3{prime} ends of short gaps. DNA binding and gap filling are well characterized for 1-nucleotide (nt) gaps, but the location of yet-to-be-copied template nucleotides in longer gaps is unknown. Here we present crystal structures revealing that, when bound to a 2-nt gap, Pol {lambda} scrunches the template strand and binds the additional uncopied template base in an extrahelical position within a binding pocket that comprises three conserved amino acids. Replacing these amino acids with alanine results in less processive gap filling and less efficient NHEJ when 2-nt gaps are involved. Thus, akin to scrunching by RNA polymerase during transcription initiation, scrunching occurs during gap filling DNA synthesis associated with DNA repair.

Garcia-Diaz, Miguel; Bebenek, Katarzyna; Larrea, Andres A.; Havener, Jody M.; Perera, Lalith; Krahn, Joseph M.; Pedersen, Lars C.; Ramsden, Dale A.; Kunkel, Thomas A.; (NIH); (UNC)

2009-09-25T23:59:59.000Z

342

Nondestructive evaluation and characterization of damage and repair to continuous-fiber ceramic composite panels.  

SciTech Connect (OSTI)

Continuous fiber ceramic matrix composites are currently being developed for a variety of high-temperature applications. Because of the high costs of making these components, minor damage incurred during manufacturing or operation must be rewired in order to extend the life of the components. In this study, five ceramic-grade Nicalon{trademark} fiber/SiNC-matrix composite panels were intentionally damaged with a pendulum-type impactor during an impact test. The damaged panels were then repaired at Dow Corning Corporation. Three nondestructive evaluation (NDE) methods were used to study the characteristics of the panels after the damage and again after the panels were repaired. The NDE methods were X-ray radiography, infrared thermal imaging, and air-coupled ultrasound. The results showed that the impact test induced various types of damage in the panels. The NDE data that were obtained by the three NDE methods were correlated with each other.

Sun, J. G.; Petrak, D. R.; Pillai, T. A. K.; Deemer, C.; Ellingson, W. A.

1998-04-01T23:59:59.000Z

343

"You Can Do It" Basic Home Repair Using Hand and Power Tools  

E-Print Network [OSTI]

1 "You Can Do It" Basic Home Repair Using Hand and Power Tools by Janie L. Harris Extension Housing guard housing. Place the tool rest 1/8 inch from the wheel on bench-mounted units. Before starting://www.cdc.gov/nasd/docs/ University of Denver, Risk Management http://www.du.edu/risk/Tool_Safety.html #12;2 "You Can Do It" Basic

344

REPAIR OF A DAMAGED PART ON HYDRAULIC TRACT KAPLAN TURBINE WITH "LIQUID METAL"  

E-Print Network [OSTI]

During 2011 on unit no.2 reparation work was carried out aimed at fault removal on Kaplan turbine impeller, while extending the lifespan of the entire installed equipment. The overhaul included all vital parts, replacement of all gasket compresses, machine processing to achieve the required tolerances, NDT equipment control according to "Quality Control Plan", repairing equipment, etc. This paper describes the recovery of defects on the blades of the guide vanes using epoxy masses.

Fuad ?atovi?; Prof Emeritus; Edin Džiho Msc; Mostar Bih; Mustafa Šehi?; Hydroelectric Power Plant Neretva; Jablanica Bih

345

Endovascular Repair of a Pseudoaneurysm of the Abdominal Aorta Secondary to Translumbar Aortography  

SciTech Connect (OSTI)

This report describes an incidental finding of a pseudoaneurysm of the abdominal aorta on a computed tomography (CT) renal angiogram during investigation of chronic renal failure in a 73-year-old man. The patient had undergone a translumbar aortogram 20 years previously. An increase in the size of the aneurysm by 7 mm over 6 months prompted treatment and the aneurysm underwent successful endovascular repair with a custom-made stent-graft.

Mir, Naheed; Nunzio, Mario De; Pollock, John G [Derbyshire Royal Infirmary, Department of Clinical Radiology (United Kingdom)], E-mail: JG.Pollock@derbyhospitals.nhs.uk

2006-12-15T23:59:59.000Z

346

Symmetry breaking patterns and collective modes of spin-one color superconductors  

E-Print Network [OSTI]

Spin-one color superconductor is a viable candidate phase of dense matter in the interiors of compact stars. Its low-energy excitations will influence the transport properties of such matter and thus have impact on late-stage evolution of neutron stars. It also provides a good example of spontaneous symmetry breaking with rich breaking patterns. In this contribution, we reanalyze the phase diagram of a spin-one color superconductor and point out that a part of it is occupied by noninert states, which have been neglected in literature so far. We classify the collective Nambu--Goldstone modes, which are essential to the transport phenomena.

Tomas Brauner; Jin-yi Pang; Qun Wang

2009-09-23T23:59:59.000Z

347

The concepts of leak before break and absolute reliability of NPP equipment and piping  

SciTech Connect (OSTI)

This paper describes the absolute reliability (AR) concept for ensuring safe operation of nuclear plant equipment and piping. The AR of a pipeline or component is defined as the level of reliability when the probability of an instantaneous double-ended break is near zero. AR analysis has been applied to Russian RBMK and VVER type reactors. It is proposed that analyses required for application of the leak before break concept should be included in AR implementation. The basic principles, methods, and approaches that provide the basis for implementing the AR concept are described.

Getman, A.F.; Komarov, O.V.; Sokov, L.M. [and others

1997-04-01T23:59:59.000Z

348

Semiclassical treatment of symmetry breaking and bifurcations in a non-integrable potential  

E-Print Network [OSTI]

We have derived an analytical trace formula for the level density of the H\\'enon-Heiles potential using the improved stationary phase method, based on extensions of Gutzwiller's semiclassical path integral approach. This trace formula has the correct limit to the standard Gutzwiller trace formula for the isolated periodic orbits far from all (critical) symmetry-breaking points. It continuously joins all critical points at which an enhancement of the semiclassical amplitudes occurs. We found a good agreement between the semi- classical and the quantum oscillating level densities for the gross shell structures and for the energy shell corrections, solving the symmetry breaking problem at small energies.

M. V. Koliesnik; Ya. D. Krivenko-Emetov; A. G. Magner; K. Arita; M. Brack

2014-11-10T23:59:59.000Z

349

Wave breaking phenomenon of lower-hybrid oscillations induced by a background inhomogeneous magnetic field  

SciTech Connect (OSTI)

In a fluid description, we study space-time evolution of lower hybrid modes in a cold quasi-neutral homogeneous plasma in presence of a background inhomogeneous magnetic field. Within a linear analysis, a dispersion relation with inhomogeneous magnetic field shows 'phase mixing' of such oscillations. A manifestation of 'phase mixing' is shown in 'mode coupling.' By using Lagrangian variables, an exact solution is presented in parametric form of this nonlinear time dependent problem. It is demonstrated that initially excited lower hybrid modes always break via phase mixing phenomenon in presence of an inhomogeneous magnetic field. Breaking of such oscillations is revealed by the appearance of spikes in the plasma density profile.

Maity, Chandan; Chakrabarti, Nikhil [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064 (India); Sengupta, Sudip [Institute for Plasma Research, Bhat, Gandhinagar 382428 (India)

2012-10-15T23:59:59.000Z

350

LENS repair and modification of metal NW components:materials and applications guide.  

SciTech Connect (OSTI)

Laser Engineered Net Shaping{trademark} (LENS{reg_sign}) is a unique, layer additive, metal manufacturing technique that offers the ability to create fully dense metal features and components directly from a computer solid model. LENS offers opportunities to repair and modify components by adding features to existing geometry, refilling holes, repairing weld lips, and many other potential applications. The material deposited has good mechanical properties with strengths typically slightly higher that wrought material due to grain refinement from a quickly cooling weld pool. The result is a material with properties similar to cold worked material, but without the loss in ductility traditionally seen with such treatments. Furthermore, 304L LENS material exhibits good corrosion resistance and hydrogen compatibility. This report gives a background of the LENS process including materials analysis addressing the requirements of a number of different applications. Suggestions are given to aid both the product engineer and the process engineer in the successful utilization of LENS for their applications. The results of testing on interface strength, machinability, weldability, corrosion resistance, geometric effects, heat treatment, and repair strategy testing are all included. Finally, the qualification of the LENS process is briefly discussed to give the user confidence in selecting LENS as the process of choice for high rigor applications. The testing showed LENS components to have capability in repair/modification applications requiring complex castings (W80-3 D-Bottle bracket), thin wall parts requiring metal to be rebuilt onto the part (W87 Firing Set Housing and Y-12 Test Rings), the filling of counterbores for use in reservoir reclamation welding (SRNL hydrogen compatibility study) and the repair of surface defects on pressure vessels (SRNL gas bottle repair). The material is machinable, as testing has shown that LENS deposited material machines similar to that of welded metal. Tool wear is slightly higher in LENS material than in wrought material, but not so much that one would be concerned with increased tooling cost. The LENS process achieved process qualification for the AY1E0125 D-Bottle Bracket from the W80-3 LEP program, and in the effort, also underwent testing in weapons environments. These tests included structural dynamic response testing and drop testing. The LENS deposited parts were compared in these tests with conventionally machined parts and showed equivalency to such an extent that the parts were accepted for use in parallel path subsystem-level weapon environment testing. The evaluation of LENS has shown that the process can be a viable option when either complete metal parts are needed or existing metal parts require modification or repair. The LENS Qualification Technology Investment team successfully investigated new applications for the LENS process and showed that it has great applicability across the Nuclear Weapons Complex as well as in other high rigor applications.

Smugeresky, John E. (Sandia National Laboratories, Livermore, CA); Gill, David Dennis; Oberhaus, Jason (BWXT Y-12); Adams, Thad (Savannah River National Laboratory); VanCamp, Chad (Kansas City Plant)

2006-11-01T23:59:59.000Z

351

Constituent Particle Break-up during Hot Rolling of AA 5182 Nicolas Moulin(1)  

E-Print Network [OSTI]

Constituent Particle Break-up during Hot Rolling of AA 5182 Nicolas Moulin(1) , Estelle Parra hot reversible rolling of AA5182 alloy sheets has been analysed. The sizes and shapes of intermetallic particles in as-cast and industrially hot rolled AA5182 alloys sheets were characterized by 3D X ray

Paris-Sud XI, Université de

352

Implications of different supersymmetry breaking patterns for the spectrum and decay of neutralinos and charginos  

SciTech Connect (OSTI)

We consider different patterns of supersymmetry breaking gaugino mass parameters, and implications of these patterns for the phenomenology of neutralinos and charginos in models of low-energy supersymmetry. We outline a general procedure for obtaining approximate values for the neutralino masses relevant for our analysis, and describe the constraints on the gaugino mass parameters which follow from the present experimental limits on the mass of the lightest chargino. We evaluate an upper bound on the mass of the lightest neutralino that follows from the structure of the mass matrix in the studied patterns. Using the experimental lower limit for the chargino mass, we examine the lower bound for the neutralino masses. Using a sum rule for the squared masses of charginos and neutralinos, we discuss how to distinguish between different models for the supersymmetry breaking. We discuss in detail the decay modes of neutralinos and charginos. Our analysis shows that by measuring the masses and decay properties of the neutralinos, one can distinguish between different patterns of supersymmetry breaking in the gaugino sector. We then compare the dark matter characteristics that arise in different models for the supersymmetry breaking gaugino mass parameters.

Huitu, Katri; Tiitola, Paavo [Department of Physics / Helsinki Institute of Physics, University of Helsinki, P.O. Box 64, FIN-00014 Helsinki (Finland); Laamanen, Jari [Theoretical High Energy Physics, Radboud University Nijmegen, P.O. Box 9010, NL-6500 GL Nijmegen (Netherlands); Institut fuer Physik, Technische Universitaet Dortmund, D-44221 Dortmund (Germany); Pandita, P. N. [Department of Physics, North Eastern Hill University, Shillong 793 022 (India)

2010-12-01T23:59:59.000Z

353

XXII ICTAM, 2529 August 2008, Adelaide, Australia SPACE-TIME MEASUREMENTS OF BREAKING WAVE KINEMATICS  

E-Print Network [OSTI]

with light intensity. WAVE KINEMATICS Phase average vorticity In order to have a statistical evolutionXXII ICTAM, 25­29 August 2008, Adelaide, Australia SPACE-TIME MEASUREMENTS OF BREAKING WAVE KINEMATICS AND VOID FRACTION IN THE SURF ZONE Olivier Kimmoun1 , 2 Hubert Branger1 1IRPHE, CNRS, Aix

Paris-Sud XI, Université de

354

Electronic Heating at High Bias in Atomic-Scale Au Break Junctions Ruoyu Chen,1  

E-Print Network [OSTI]

, U.S.A. Heating in nanoscale systems driven out of equilibrium is of fundamental importance, has O-10 Electronic Heating at High Bias in Atomic-Scale Au Break Junctions Ruoyu Chen,1, Texas, U.S.A. 2 Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005

355

Draft Final (13/6/01) Summary of Diagnostics Break Out Session at BPS Workshop 2  

E-Print Network [OSTI]

challenge, arguably the most difficult challenge ever undertaken in plasma diagnostics The challenge must wall and plasma measurements will be required to support a BPX; (ii) what is the status of diagnosticPage 1 Draft Final (13/6/01) Summary of Diagnostics Break Out Session at BPS Workshop 2 Prepared

356

A BreakEven Formulation for Evaluating Branch Predictor Energy Efficiency #  

E-Print Network [OSTI]

A Break­Even Formulation for Evaluating Branch Predictor Energy Efficiency # Michele Co, Dee A demonstrated that a better branch pre­ dictor can increase the energy­efficiency of the system, even if the new a simple, effective metric for eval­ uating the tradeoff between processor energy­efficiency and branch

Co, Michele

357

Observation of the Ankle and Evidence for a High-Energy Break in the Cosmic Ray  

E-Print Network [OSTI]

Observation of the Ankle and Evidence for a High-Energy Break in the Cosmic Ray Spectrum R known as "the ankle" near 3 Ã? 1018 eV, and strong evidence for a supression near 6 Ã? 1019 eV. 1

358

Total Break of the -IC Signature Scheme Pierre-Alain Fouque1  

E-Print Network [OSTI]

- analysis of multivariate schemes and have lead to the efficient break of SFLASH in practice. In this work- signature scheme recently proposed at PKC 2007. This cryptosystem is a multivariate scheme based on a new internal quadratic primitive which avoids some drawbacks of previous multivari- ate schemes: the scheme

Fouque, Pierre-Alain

359

Breaking POET Authentication with a Single Query Jian Guo, Jeremy Jean, Thomas Peyrin, and Lei Wang  

E-Print Network [OSTI]

Breaking POET Authentication with a Single Query Jian Guo, J´er´emy Jean, Thomas Peyrin, and Lei article, we describe a very practical and simple attack on the au- thentication part of POET authenticated encryption mode proposed at FSE 2014. POET is a provably secure scheme that was designed to resist various

360

Trends and breaks in per-capita carbon dioxide emissions, 1870-2028  

E-Print Network [OSTI]

We consider per-capita carbon dioxide emission trends in 16 early developed countries over the period 1870-2028. Using a multiple-break time series method we find more evidence for very early downturns in per-capita trends ...

Lanne, Markku

2003-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Instability of two-dimensional graphene: Breaking sp2 bonds with soft x rays  

E-Print Network [OSTI]

Instability of two-dimensional graphene: Breaking sp2 bonds with soft x rays S. Y. Zhou,1,2 Ç. Ö the stability of various kinds of graphene samples under soft x-ray irradiation. Our results show that in single-layer exfoliated graphene a closer analog to two-dimensional material , the in-plane carbon- carbon bonds

Zettl, Alex

362

Facebook, Twitter and Google Plus for Breaking News: Is there a winner? Miles Osborne  

E-Print Network [OSTI]

Facebook, Twitter and Google Plus for Breaking News: Is there a winner? Miles Osborne School Media have be- gun to carry news. Here we examine how Facebook, Google Plus and Twitter report Facebook or Google Plus. Face- book and Google Plus largely repost newswire stories and their main research

Osborne, Miles

363

All Your Face Are Belong to Us: Breaking Facebook's Social Authentication  

E-Print Network [OSTI]

All Your Face Are Belong to Us: Breaking Facebook's Social Authentication Iasonas Polakis FORTH adversaries from compromising accounts using stolen credentials. Facebook has recently released a two can obtain the information needed to solve the chal- lenges presented by Facebook. We implement

Yang, Junfeng

364

Multiple Structural Breaks in India's GDP: Evidence from India's Service Sector  

E-Print Network [OSTI]

of economists and policy makers. India was designated as an agricultural country with a highest share1 Multiple Structural Breaks in India's GDP: Evidence from India's Service Sector Purba Roy Choudhury1 Abstract: This paper takes a comprehensive investigation into India's service sector, the main

Bandyopadhyay, Antar

365

Assessing the catastrophic break up of Briksdalsbreen, Norway,1 associated with rapid climate change.2  

E-Print Network [OSTI]

about the potential influence of rapid climate change13 on the stability of major ice sheets retreat of Greenland's tidewater glaciers.32 33 Introduction34 The response of glaciers to climate change1 Assessing the catastrophic break up of Briksdalsbreen, Norway,1 associated with rapid climate

Southampton, University of

366

Studying the Breaking Mechanism of Polymer-Based In-Situ Gelled Acids using Solid Breaker  

E-Print Network [OSTI]

of this study is to examine the working mechanisms of the solid breaker and the factors that affect the breaking time. The flowback of the spent acid and the core damage induced by it will also be assessed in detail. Viscosity and rheological experimental...

Tian, Zhida

2012-10-19T23:59:59.000Z

367

Partial degeneracy breaking of the hydrogen energy spectrum from su_q(2)  

E-Print Network [OSTI]

In this work we investigate the q-deformation of the so(4) dynamical symmetry of the hydrogen atom using the theory of the quantum group su_q(2), and construct the discrete part of the energy spectrum. This will lead to a partial breaking of the degeneracy of the energy levels and to a reduction of the Hilbert space.

P. G. Castro; R. Kullock

2012-12-07T23:59:59.000Z

368

NHMFL Breaks the 100 Tesla Barrier Gregory S. Boebinger, National High Magnetic Field Laboratory  

E-Print Network [OSTI]

NHMFL Breaks the 100 Tesla Barrier Gregory S. Boebinger, National High Magnetic Field Laboratory. 109no. 31 12404-12407 On March 22nd 2012, the NHMFL ­ Pulsed Field Facility broke the 100T tesla barrier, setting a world record of 100.75 tesla for a non-destructive magnet. By using advanced

Weston, Ken

369

Winery waste makes fuel Electricity, bacteria break organics in wastewater into hydrogen gas  

E-Print Network [OSTI]

MSNBC.com Winery waste makes fuel Electricity, bacteria break organics in wastewater into hydrogen method for generating hydrogen fuel from wastewater is now operating at a California winery material in the wastewater into hydrogen gas. There is a lot more energy locked in the wastewater than

370

Numerical Simulation of Breaking Waves Using Level-Set Navier-Stokes Method  

E-Print Network [OSTI]

) equations were employed for the prediction of nonlinear wave-interaction and wave-breaking phenomena over sloping beaches. In the level-set finite-analytic Navier-Stokes (FANS) method, the free surface is represented by the zero level-set function...

Dong, Qian

2010-07-14T23:59:59.000Z

371

Mathematical model and simulation of gas ow through a porous medium in high breaking capacity  

E-Print Network [OSTI]

Mathematical model and simulation of gas #29;ow through a porous medium in high breaking capacity, France. Abstract. A one-dimensional model is introduced to describe the gas #29;ow and the heat transfer model coupled with a porous medium model taking into account the mechanical interaction gas-silica sand

Sart, Remi

372

Role of global warming on the statistics of record-breaking temperatures S. Redner1,  

E-Print Network [OSTI]

Role of global warming on the statistics of record-breaking temperatures S. Redner1, * and Mark R in Philadelphia, as a function of the number of years of observation. We then consider the case of global warming question arises: is global warming the cause of such heat waves or are they merely statistical fluctuations

Redner, Sidney

373

Symmetry-breaking thermally induced collapse of dipolar Bose-Einstein condensates Andrej Junginger,  

E-Print Network [OSTI]

Symmetry-breaking thermally induced collapse of dipolar Bose-Einstein condensates Andrej Junginger LE11 3TU, UK (Dated: August 13, 2012) We investigate a Bose-Einstein condensate with additional long" that mediates the collapse of the condensate. For a certain value of the s-wave scatting length our

374

The University of New Hampshire in 2020: Breaking Silos, Transforming Lives, Reimagining the University  

E-Print Network [OSTI]

their historic mission and respond energetically and effectively to these new challenges? The University of New1 The University of New Hampshire in 2020: Breaking Silos, Transforming Lives, Reimagining of our state, our nation and our world. For 143 years we have served the people and communities of New

375

University Of Kentucky Supercomputer Breaks The $1,000 Per GFLOPS Barrier  

E-Print Network [OSTI]

University Of Kentucky Supercomputer Breaks The $1,000 Per GFLOPS Barrier May 22, 2000, Lexington, Kentucky May 2000, Lexington, Kentucky: Researchers at the University of Kentucky have constructed that cost down to about $3,000 per GFLOPS. KLAT2, Kentucky Linux Athlon Testbed 2 (http

Dietz, Henry G. "Hank"

376

Hydrogen Bond Networks: Structure and Evolution after Hydrogen Bond Breaking John B. Asbury, Tobias Steinel, and M. D. Fayer*  

E-Print Network [OSTI]

Hydrogen Bond Networks: Structure and Evolution after Hydrogen Bond Breaking John B. Asbury, TobiasVed: September 1, 2003; In Final Form: December 18, 2003 The nature of hydrogen bonding networks following hydrogen bond breaking is investigated using vibrational echo correlation spectroscopy of the hydroxyl

Fayer, Michael D.

377

Effects of intermittent entrainment of air bubbles by breaking wind waves on ocean reflectance and underwater light field  

E-Print Network [OSTI]

Effects of intermittent entrainment of air bubbles by breaking wind waves on ocean reflectance, 2000]. The intermittent nature of air entrainment by breaking waves manifests itself as dramatic, Polish Academy of Sciences, Sopot, Poland Abstract. Light-scattering properties of air bubbles suspended

Stramski, Dariusz

378

Proposal to negotiate two contracts, without competitive tendering, for the supply and the repair of compressors for the LHC 18 kW helium refrigeration plants  

E-Print Network [OSTI]

Proposal to negotiate two contracts, without competitive tendering, for the supply and the repair of compressors for the LHC 18 kW helium refrigeration plants

2011-01-01T23:59:59.000Z

379

Development and validation of nondestructive inspection techniques for composite doubler repairs on commercial aircraft  

SciTech Connect (OSTI)

Composite doublers, or repair patches, provide an innovative repair technique which can enhance the way aircraft are maintained. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is possible to bond a single boron-epoxy composite doubler to the damaged structure. In order for the use of composite doublers to achieve widespread use in the civil aviation industry, it is imperative that methods be developed which can quickly and reliably assess the integrity of the doubler. In this study, a specific composite application was chosen on an L-1011 aircraft in order to focus the tasks on application and operation issues. Primary among inspection requirements for these doublers is the identification of disbonds, between the composite laminate and aluminum parent material, and delaminations in the composite laminate. Surveillance of cracks or corrosion in the parent aluminum material beneath the doubler is also a concern. No single nondestructive inspection (NDI) method can inspect for every flaw type, therefore it is important to be aware of available NDI techniques and to properly address their capabilities and limitations. A series of NDI tests were conducted on laboratory test structures and on full-scale aircraft fuselage sections. Specific challenges, unique to bonded composite doubler applications, were highlighted. An array of conventional and advanced NDI techniques were evaluated. Flaw detection sensitivity studies were conducted on applicable eddy current, ultrasonic, X-ray and thermography based devices. The application of these NDI techniques to composite doublers and the results from test specimens, which were loaded to provide a changing flaw profile, are presented in this report. It was found that a team of these techniques can identify flaws in composite doubler installations well before they reach critical size.

Roach, D.; Walkington, P.

1998-05-01T23:59:59.000Z

380

Endovascular Stent-Graft Repair as a Late Secondary Procedure After Previous Aortic Grafts  

SciTech Connect (OSTI)

Thoracic and abdominal aortic endovascular procedures as alternatives to aortic reoperations were studied in three different cases. An anastomotic aneurysm after previous thoracic aortic graft for coarctation, a second-stage elephant trunk repair (descending thoracic aortic aneurysm), and a secondary aneurysm proximal to a previous abdominal aortic graft were successfully treated with endovascular stent-grafts. During the follow-up period no lethal events or major aortic or graft-related complications were observed, except a type II endoleak in the anastomotic aortic aneurysm case. An endovascular stent-graft can be safely deployed into a previously implanted vascular graft, avoiding repeat surgery.

Matsagas, Miltiadis I. [School of Medicine, University of Ioannina, Department of Surgery - Vascular Surgery Unit (Greece)], E-mail: mimats@cc.uoi.gr; Anagnostopoulos, Constantine E. [School of Medicine, University of Ioannina, Department of Cardiothoracic Surgery (Greece); Papakostas, John C. [School of Medicine, University of Ioannina, Department of Surgery - Vascular Surgery Unit (Greece); DeRose, Joseph J. [St. Luke's-Roosevelt Hospital, Columbia University, Department of Cardiothoracic Surgery (United States); Siminelakis, Stavros [School of Medicine, University of Ioannina, Department of Cardiothoracic Surgery (Greece); Katsouras, Christos S. [School of Medicine, University of Ioannina, Department of Cardiology (Greece); Toumpoulis, Ioannis K.; Drossos, George E. [School of Medicine, University of Ioannina, Department of Cardiothoracic Surgery (Greece); Michalis, Lampros K. [School of Medicine, University of Ioannina, Department of Cardiology (Greece)

2006-08-15T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Exposure Evaluation for Benzene, Lead and Noise in Vehicle and Equipment Repair Shops  

SciTech Connect (OSTI)

An exposure assessment was performed at the equipment and vehicle maintenance repair shops operating at the U. S. Department of Energy Hanford site, in Richland, Washington. The maintenance shops repair and maintain vehicles and equipment used in support of the Hanford cleanup mission. There are three general mechanic shops and one auto body repair shop. The mechanics work on heavy equipment used in construction, cranes, commercial motor vehicles, passenger-type vehicles in addition to air compressors, generators, and farm equipment. Services include part fabrication, installation of equipment, repair and maintenance work in the engine compartment, and tire and brake services. Work performed at the auto body shop includes painting and surface preparation which involves applying body filler and sanding. 8-hour time-weighted-average samples were collected for benzene and noise exposure and task-based samples were collected for lead dust work activities involving painted metal surfaces. Benzene samples were obtained using 3M™ 3520 sampling badges and were analyzed for additional volatile organic compounds. These compounds were selected based on material safety data sheet information for the aerosol products used by the mechanics for each day of sampling. The compounds included acetone, ethyl ether, toluene, xylene, VM&P naphtha, methyl ethyl ketone, and trichloroethylene. Laboratory data for benzene, VM&P naphtha, methyl ethyl ketone and trichloroethylene were all below the reporting detection limit. Airborne concentrations for acetone, ethyl ether, toluene and xylene were all less than 10% of their occupational exposure limit. The task-based samples obtained for lead dusts were submitted for a metal scan analysis to identify other metals that might be present. Laboratory results for lead dusts were all below the reporting detection limit and airborne concentration for the other metals observed in the samples were less than 10% of the occupational exposure limit. Noise dosimetry sampling was performed on a random basis and was representative of the different work activities within the four shops. Twenty three percent of the noise samples exceeded the occupational exposure limit of 85 decibels for an 8-hour time-weightedaverage. Work activities where noise levels were higher included use of impact wrenches and grinding wheels.

Sweeney, Lynn C.

2013-04-10T23:59:59.000Z

382

Study of charge symmetry breaking in dd collisions with WASA-at-COSY  

SciTech Connect (OSTI)

Charge symmetry is an approximate symmetry of the strong interaction. Studies of its breaking can yield information on the u and d quark mass difference. A theoretical collaboration is currently working on the description of charge symmetry breaking mechanisms for dd{yields}{alpha}{pi}{sup 0} and np{yields}d{pi}{sup 0} within Chiral Perturbation Theory, using the data from TRI-UMF and IUCF. One of the items in the program of the WASA-at-COSY collaboration is to extend the data base for the dd{yields}{alpha}{pi}{sup 0} reaction to higher energies, which would allow the extraction of the information on the p-wave. Status of the analysis of experimental data along with the preliminary results from the pilot run will be presented here.

Wronska, Aleksandra [Institute of Physics, Jagiellonian University, Cracow, Reymonta 4, 30-059 Cracow (Poland)

2011-10-24T23:59:59.000Z

383

A Free Energy Landscape for Cage Breaking of Three Hard Disks  

E-Print Network [OSTI]

We investigate cage breaking in dense hard disk systems using a model of three Brownian disks confined within a circular corral. This system has a six-dimensional configuration space, but can be equivalently thought to explore a symmetric one-dimensional free energy landscape containing two energy minima separated by an energy barrier. The exact free energy landscape can be calculated as a function of system size. Results of simulations show the average time between cage breaking events follows an Arrhenius scaling when the energy barrier is large. We also discuss some of the consequences of using a one-dimensional representation to understand dynamics in a multi-dimensional space, such as diffusion acquiring spatial dependence and discontinuities in spatial derivatives of free energy.

Gary L. Hunter; Eric R. Weeks

2011-12-21T23:59:59.000Z

384

Breaking of relativistically intense longitudinal space charge waves: A description using Dawson sheet model  

SciTech Connect (OSTI)

Spatio-temporal evolution of relativistically intense longitudinal space charge waves in a cold homogeneous plasma is studied analytically as well as numerically, as an initial value problem, using Dawson sheet model. It is found that, except for very special initial conditions which generates the well known longitudinal Akhiezer-Polovin mode, for all other initial conditions, the waves break through a novel mechanism called phase mixing at an amplitude well below the Akhiezer-Polovin limit. An immediate consequence of this is, that Akhiezer-Polovin waves break when subjected to arbitrarily small longitudinal perturbations. We demonstrate this by performing extensive numerical simulations. This result may be of direct relevance to ultrashort, ultraintense laser/beam pulse-plasma interaction experiments where relativistically intense waves are routinely excited.

Sengupta, Sudip, E-mail: sudip@ipr.res.in [Institute for Plasma Research, Bhat , Gandhinagar - 382428 (India)

2014-02-11T23:59:59.000Z

385

Numerical Analysis of the Internal Kinematics and Dynamics of Three-dimensional Breaking Waves on B. Biausser, S.T. Grilli, P. Frauni  

E-Print Network [OSTI]

Numerical Analysis of the Internal Kinematics and Dynamics of Three-dimensional Breaking Waves/Navier-Stokes solver. Analysis of wave profiles and kinematics (velocity, vorticity, pressure) are carried out. Keyword the breaking and post-breaking in a three- dimensional numerical wave tank of a solitary wave over a sloping

Grilli, Stéphan T.

386

Watching Hydrogen Bonds Break: A Transient Absorption Study of Water Tobias Steinel, John B. Asbury, Junrong Zheng, and M. D. Fayer*  

E-Print Network [OSTI]

Watching Hydrogen Bonds Break: A Transient Absorption Study of Water Tobias Steinel, John B. Asbury of picoseconds, observe hydrogen bond breaking and monitor the equilibration of the hydrogen bond network in water. In addition, the vibrational lifetime, the time constant for hydrogen bond breaking, and the rate

Fayer, Michael D.

387

Isospin symmetry breaking and baryon-isospin correlations from Polyakov$-$Nambu$-$Jona-Lasinio model  

E-Print Network [OSTI]

We present a study of the 1+1 flavor system of strongly interacting matter in terms of the Polyakov$-$Nambu$-$Jona-Lasinio model. We find that though the small isospin symmetry breaking brought in through unequal light quark masses is too small to affect the thermodynamics of the system in general, it may have significant effect in baryon-isospin correlations and have a measurable impact in heavy-ion collision experiments.

Abhijit Bhattacharyya; Sanjay K. Ghosh; Anirban Lahiri; Sarbani Majumder; Sibaji Raha; Rajarshi Ray

2014-06-11T23:59:59.000Z

388

On the breaking and restoration of symmetries within the nuclear energy density functional formalism  

E-Print Network [OSTI]

We review the notion of symmetry breaking and restoration within the frame of nuclear energy density functional methods. We focus on key differences between wave-function- and energy-functional-based methods. In particular, we point to difficulties encountered within the energy functional framework and discuss new potential constraints on the underlying energy density functional that could make the restoration of broken symmetries better formulated within such a formalism. We refer to Ref.~\\cite{duguet10a} for details.

T. Duguet; J. Sadoudi

2010-10-19T23:59:59.000Z

389

Breaking Up (Hydrogen) No Longer As Hard To Do | Department of Energy  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energy UsageAUDITVehiclesTankless orA BRIEFApril 2015CommerceDepartmentBlowerBreaking Up

390

A Mechanism-Based Approach to Predict the Relative Biological Effectiveness of Protons and Carbon Ions in Radiation Therapy  

SciTech Connect (OSTI)

Purpose: The physical and potential biological advantages of proton and carbon ions have not been fully exploited in radiation therapy for the treatment of cancer. In this work, an approach to predict proton and carbon ion relative biological effectiveness (RBE) in a representative spread-out Bragg peak (SOBP) is derived using the repair-misrepair-fixation (RMF) model. Methods and Materials: Formulas linking dose-averaged linear-quadratic parameters to DSB induction and processing are derived from the RMF model. The Monte Carlo Damage Simulation (MCDS) software is used to quantify the effects of radiation quality on the induction of DNA double-strand breaks (DSB). Trends in parameters {alpha} and {beta} for clinically relevant proton and carbon ion kinetic energies are determined. Results: Proton and carbon ion RBE are shown to increase as particle energy, dose, and tissue {alpha}/{beta} ratios decrease. Entrance RBE is {approx}1.0 and {approx}1.3 for protons and carbon ions, respectively. For doses in the range of 0.5 to 10 Gy, proton RBE ranges from 1.02 (proximal edge) to 1.4 (distal edge). Over the same dose range, the RBE for carbon ions ranges from 1.5 on the proximal edge to 6.7 on the distal edge. Conclusions: The proposed approach is advantageous because the RBE for clinically relevant particle distributions is guided by well-established physical and biological (track structure) considerations. The use of an independently tested Monte Carlo model to predict the effects of radiation quality on DSB induction also minimizes the number of ad hoc biological parameters that must be determined to predict RBE. Large variations in predicted RBE across an SOBP may produce undesirable biological hot and cold spots. These results highlight the potential for the optimization of physical dose for a uniform biological effect.

Frese, Malte C. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Medical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg (Germany); Yu, Victor K. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Stewart, Robert D. [Department of Radiation Oncology, University of Washington, Seattle, Washington (United States); Carlson, David J., E-mail: david.j.carlson@yale.edu [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)

2012-05-01T23:59:59.000Z

391

Molecular Imaging of the ATM Kinase Activity  

SciTech Connect (OSTI)

Purpose: Ataxia telangiectasia mutated (ATM) is a serine/threonine kinase critical to the cellular DNA-damage response, including from DNA double-strand breaks. ATM activation results in the initiation of a complex cascade of events including DNA damage repair, cell cycle checkpoint control, and survival. We sought to create a bioluminescent reporter that dynamically and noninvasively measures ATM kinase activity in living cells and subjects. Methods and Materials: Using the split luciferase technology, we constructed a hybrid cDNA, ATM-reporter (ATMR), coding for a protein that quantitatively reports on changes in ATM kinase activity through changes in bioluminescence. Results: Treatment of ATMR-expressing cells with ATM inhibitors resulted in a dose-dependent increase in bioluminescence activity. In contrast, induction of ATM kinase activity upon irradiation resulted in a decrease in reporter activity that correlated with ATM and Chk2 activation by immunoblotting in a time-dependent fashion. Nuclear targeting improved ATMR sensitivity to both ATM inhibitors and radiation, whereas a mutant ATMR (lacking the target phosphorylation site) displayed a muted response. Treatment with ATM inhibitors and small interfering (si)RNA-targeted knockdown of ATM confirm the specificity of the reporter. Using reporter expressing xenografted tumors demonstrated the ability of ATMR to report in ATM activity in mouse models that correlated in a time-dependent fashion with changes in Chk2 activity. Conclusions: We describe the development and validation of a novel, specific, noninvasive bioluminescent reporter that enables monitoring of ATM activity in real time, in vitro and in vivo. Potential applications of this reporter include the identification and development of novel ATM inhibitors or ATM-interacting partners through high-throughput screens and in vivo pharmacokinetic/pharmacodynamic studies of ATM inhibitors in preclinical models.

Williams, Terence M. [Department of Radiation Oncology, Ohio State University, Columbus, Ohio (United States); Nyati, Shyam [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Ross, Brian D. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Rehemtulla, Alnawaz, E-mail: alnawaz@umich.edu [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)

2013-08-01T23:59:59.000Z

392

New Supersoft Supersymmetry Breaking Operators and a Solution to the $?$ Problem  

E-Print Network [OSTI]

We propose the framework, "generalized supersoft supersymmetry breaking". "Supersoft" models, with $D$-type supersymmetry breaking and heavy Dirac gauginos, are considerably less constrained by the LHC searches than the well studied MSSM. These models also ameliorate the supersymmetric flavor and $CP$ problems. However, previously considered mechanisms for obtaining a natural size Higgsino mass parameter (namely, $\\mu$) in supersoft models have been relatively complicated and contrived. Obtaining a $125\\gev$ for the mass of the lightest Higgs boson has also been difficult. Additional issues with the supersoft scenario arise from the fact that these models contain new scalars in the adjoint representation of the standard model, which may obtain negative squared-masses, breaking color and generating too large a $T$-parameter. In this work we introduce new operators into supersoft models which can potentially solve all these issues. A novel feature of this framework is that the new $\\mu$-term can give unequal masses to the up and down type Higgs fields, and the Higgsinos can be much heavier than the Higgs boson without fine-tuning. However, unequal Higgs and Higgsino masses can also destroy some attractive features of supersoft susy.

Ann E. Nelson; Tuhin S. Roy

2015-01-20T23:59:59.000Z

393

Light scalar as the messenger of electroweak and flavor symmetry breaking  

SciTech Connect (OSTI)

We propose a new framework for understanding the hierarchies of fermion masses and mixings. The masses and mixings of all standard model (SM) charged fermions other than top arise from higher dimensional operators involving a messenger scalar S and flavon scalars F{sub i}. The flavons spontaneously break SM flavor symmetries at around the TeV scale. The SM singlet scalar S couples directly to the Higgs H and spontaneously breaks another U(1) at the electroweak scale. At the TeV scale, SM quarks and charged leptons have renormalizable couplings to S, but not to H or F{sub i}. These couplings involve new heavy vectorlike fermions. Integrating out these fermions produces a pattern of higher dimensional operators that reproduce the observed hierarchies of the SM masses and mixings in terms of powers of the 'little hierarchy': the ratio of the electroweak scale to the flavor-breaking scale. The framework has important phenomenological implications. Flavor-changing neutral currents are within experimental limits but D{sup 0}-D{sup 0} mixing and B{sub s}{yields}{mu}{sup +}{mu}{sup -} could be close to current sensitivities. The neutral scalar s of the messenger field mixes with the light Higgs of the SM, which can have strong effects on Higgs decay branching fractions. The s mass eigenstate may be lighter than the Higgs, and could be detected at the Tevatron or the LHC.

Lykken, J. D. [Theoretical Physics Department, Fermilab, P.O. Box 500, Batavia, Illinois 60510 (United States); Murdock, Z. [Department of Physics and Oklahoma Center for High Energy Physics, Oklahoma State University, Stillwater, Oklahoma 74078 (United States); Nandi, S. [Theoretical Physics Department, Fermilab, P.O. Box 500, Batavia, Illinois 60510 (United States); Department of Physics and Oklahoma Center for High Energy Physics, Oklahoma State University, Stillwater, Oklahoma 74078 (United States)

2009-04-01T23:59:59.000Z

394

Canonical Gauge Coupling Unification in the Standard Model with High-Scale Supersymmetry Breaking  

E-Print Network [OSTI]

Inspired by the string landscape and the unified gauge coupling relation in the F-theory Grand Unified Theories (GUTs) and GUTs with suitable high-dimensional operators, we study the canonical gauge coupling unification and Higgs boson mass in the Standard Model (SM) with high-scale supersymmetry breaking. In the SM with GUT-scale supersymmetry breaking, we achieve the gauge coupling unification at about 5.3 x 10^{13} GeV, and the Higgs boson mass is predicted to range from 130 GeV to 147 GeV. In the SM with supersymmetry breaking scale from 10^4 GeV to 5.3 x 10^{13} GeV, gauge coupling unification can always be realized and the corresponding GUT scale M_U is from 10^{16} GeV to 5.3 x 10^{13} GeV, respectively. Also, we obtain the Higgs boson mass from 114.4 GeV to 147 GeV. Moreover, the discrepancies among the SM gauge couplings at the GUT scale are less than about 4-6%. Furthermore, we present the SU(5) and SO(10) models from the F-theory model building and orbifold constructions, and show that we do not have the dimension-five and dimension-six proton decay problems even if M_U \\le 5 x 10^{15} GeV.

Yun-Jie Huo; Tianjun Li; Dimitri V. Nanopoulos

2011-08-24T23:59:59.000Z

395

Head/tail Breaks for Visualization of City Structure and Dynamics  

E-Print Network [OSTI]

The things surrounding us vary dramatically, which implies that there are far more small things than large ones, e.g., far more small cities than large ones in the world. This dramatic variation is often referred to as fractal or scaling. To better reveal the fractal or scaling structure, a new classification scheme, namely head/tail breaks, has been developed to recursively derive different classes or hierarchical levels. The head/tail breaks works as such: divide things into a few large ones in the head (those above the average) and many small ones (those below the average) in the tail, and recursively continue the dividing process for the large ones (or the head) until the notion of far more small things than large ones has been violated. This paper attempts to argue that head/tail breaks can be a powerful visualization tool for illustrating structure and dynamics of natural cities. Natural cities refer to naturally or objectively defined human settlements based on a meaningful cutoff averaged from a massi...

Jiang, Bin

2015-01-01T23:59:59.000Z

396

IDENTIFYING BREAKS AND CURVATURE IN THE FERMI SPECTRA OF BRIGHT FLAT SPECTRUM RADIO QUASARS  

SciTech Connect (OSTI)

Knowing the site of {gamma}-ray emission in active galactic nucleus jets will do much for our understanding of the physics of the source. In particular, if the emission region is close to the black hole then absorption of {gamma}-rays with photons from the broad-line region could become significant. Such absorption is predicted to produce two specific spectral breaks in the {gamma}-ray spectra of Flat Spectrum Radio Quasars (FSRQs). We test this hypothesis using three years of Fermi observations of nine bright FSRQs. A simple power-law fit to the spectrum of each source can be significantly improved by introducing a break, but the break energies are inconsistent with those predicted by the double-absorber model. In some cases the fit can be further improved by a log-parabola. In addition, by dividing the data from each source into two equal epochs we find that the best description of an object's spectrum often varies between a log-parabola and a broken power law.

Harris, J.; Daniel, M. K.; Chadwick, P. M., E-mail: j.d.harris@durham.ac.uk [Department of Physics, Durham University, South Road, Durham DH1 3LE (United Kingdom)

2012-12-10T23:59:59.000Z

397

Simulation of a main steam line break with steam generator tube rupture using trace  

SciTech Connect (OSTI)

A simulation of the OECD/NEA ROSA-2 Project Test 5 was made with the thermal-hydraulic code TRACE5. Test 5 performed in the Large Scale Test Facility (LSTF) reproduced a Main Steam Line Break (MSLB) with a Steam Generator Tube Rupture (SGTR) in a Pressurized Water Reactor (PWR). The result of these simultaneous breaks is a depressurization in the secondary and primary system in loop B because both systems are connected through the SGTR. Good approximation was obtained between TRACE5 results and experimental data. TRACE5 reproduces qualitatively the phenomena that occur in this transient: primary pressure falls after the break, stagnation of the pressure after the opening of the relief valve of the intact steam generator, the pressure falls after the two openings of the PORV and the recovery of the liquid level in the pressurizer after each closure of the PORV. Furthermore, a sensitivity analysis has been performed to know the effect of varying the High Pressure Injection (HPI) flow rate in both loops on the system pressures evolution. (authors)

Gallardo, S.; Querol, A.; Verdu, G. [Departamento de Ingenieria Quimica Y Nuclear, Universitat Politecnica de Valencia, Camino de Vera s/n, 46022, Valencia (Spain)

2012-07-01T23:59:59.000Z

398

Steam turbine maintenance and repair technology: Reducing planned-outage costs  

SciTech Connect (OSTI)

The North American Electric Reliability Council (NAERC) reported that the average loss of equivalent availability per outage for a major fossil turbine overhaul is 323,000 MW-HR. The Electric Power Research Institute (EPRI) Generation and Storage Division, is in the first phase of a major research project to reduce the duration and/or frequency of steam turbine maintenance outages. This project consists of an assessment of the current state-of-the-art turbine maintenance and repair techniques and technologies. It is based on a review of current turbine maintenance practices of the US, European, Japanese, and Australian utility industries. Emphasized are maintenance and repair activities that have the most significant impact on outage duration or frequency. Twenty-six key turbine maintenance activities and the current best techniques were identified for use by utility maintenance personnel. Overall outage durations could be reduced if the duration of these activities were shortened or if they were performed more effectively. Recommended projects for development of advanced steam turbine maintenance technology were identified. 29 refs., 46 figs., 9 tabs.

Grace, H.P.; McClintock, M. (General Physics Corp., Columbia, MD (USA)); Lamping, G. (Southwest Research Inst., San Antonio, TX (USA))

1990-04-01T23:59:59.000Z

399

Dofasco`s No. 4 blast furnace hearth breakout, repair and rescue  

SciTech Connect (OSTI)

On May 5, 1994, after producing 9.5 million metric tons of iron, Dofasco`s No. 4 Blast Furnace experienced a hearth breakout 250 millimeters below the west taphole. The hot metal spill caused a fire resulting in severe damage and 33 days of lost production. During a 26-day period, electrical wiring, water drainage systems and both tapholes were repaired. Recovery from an unprepared furnace stop of this length, with the deadman depleted is difficult. To aid with the rescue Hoogovens-designed oxygen/fuel lances were commissioned. The furnace recovery began with a lance in each taphole and all tuyeres plugged. Six days after startup the furnace was casting into torpedo cars, and after nine days operation had returned to normal. This incident prompted Dofasco to expand the hearth monitoring system to detect and prevent similar occurrences. During the repair, 203 new thermocouples were installed in the hearth, concentrating on the tapholes and elephant foot areas. These thermocouples were installed at various depths and locations to allow heat flux calculations. This hearth monitoring system has already identified other problem areas and provided valuable information about hearth drainage patterns. This information has allowed them to develop control strategies to manage localized problem areas.

Donaldson, R.J.; Fischer, A.J.; Sharp, R.M.; Stothart, D.W. [Dofasco Inc., Hamilton, Ontario (Canada)

1995-12-01T23:59:59.000Z

400

Percutaneous Stent-Graft Repair of a Mycotic Pulmonary Artery Pseudoaneurysm  

SciTech Connect (OSTI)

Ruptured mycotic pulmonary pseudoaneurysm is a lethal complication. Emergent surgical repair is usually recommended, but still associated with a high mortality rate. We present a patient in whom mycotic pulmonary pseudoaneurysm was a complication after surgical lobectomy 2 weeks earlier. This patient had suffered from repeated massive hemoptysis. After emergent surgical repair of the ruptured pulmonary artery stump, another episode of massive hemorrhage occurred. The pulmonary arteriogram revealed a segmental stenosis and a large, wide-necked, lobulated pseudoaneurysm at the left proximal pulmonary artery. We deployed a balloon-expandable stent-graft (48 mm in length mounted on a 12 mm x 40 mm angioplasty balloon) across the stenotic segment and the neck of the pulmonary pseudoaneurysm. Hemostasis was achieved immediately and, under a 4-week antibiotic treatment, patient was transferred to a local hospital for medical care. This case report demonstrates the benefit of minimally invasive endovascular therapy in a critically ill patient. A literature review of the etiology and management of mycotic pulmonary pseudoaneurysm is included.

Chou Meichun; Liang Hueilung, E-mail: hlliang@isca.vghks.gov.tw; Pan Huayban; Yang Chienfang [Kaohsiung Veterans General Hospital, Department of Radiology (China)

2006-10-15T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Operational results of shaft repair by installing stave type cooler at Kimitsu Nos. 3 and 4 blast furnaces  

SciTech Connect (OSTI)

Nos. 3 and 4 blast furnaces in Nippon Steel Corporation Kimitsu Works were both initially fitted with cooling plate systems. With the aging of each furnace, the damage to their respective inner-shaft profiles had become serious. Thus, in order to prevent operational change and prolong the furnace life, the inner-shaft profile of each furnace was repaired by replacing the former cooling plate system with the stave type cooler during the two-week-shutdowns. With this repair, stability of burden descent and gas flow near the wall part of the furnace have been achieved. Thus the prolongation of the furnace life is naturally expected.

Oda, Hiroshi; Amano, Shigeru; Sakamoto, Aiichiro; Anzai, Osamu [Nippon Steel Corp., Kimitsu, Chiba (Japan). Kimitsu Works; Nakagome, Michiru; Kuze, Toshisuke [Nippon Steel Corp., Futtsu, Chiba (Japan); Imuta, Akira [Nippon Steel Corp., Tokyo (Japan). Plant and Machinery Div.

1997-12-31T23:59:59.000Z

402

Subj: Educational and General (E&G) Facility Support Provide an overview of Facility Operations, Maintenance, Repair and Renovation and Space  

E-Print Network [OSTI]

support, and, preventive and unscheduled maintenance of all building systems, with the exception of BAS Operations, Maintenance, Repair and Renovation and Space Management Procedures and Practices. KEY DEFINITIONS chambers, fume hoods, fixed seating, etc. are normally considered part of the building. Maintenance, repair

403

[Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, February 1, 1993--November 1, 1994  

SciTech Connect (OSTI)

This research focuses on two repair deficient mutations in Drosophila melanogaster, namely mei-9, mei-41. In addition, the authors propose to extend this study to include the mus-312 mutation. They expect these studies to provide substantial insights into both the molecular mechanisms of DNA repair in Drosophila and the role these genes play in normal biological processes.

Hawley, R.S.

1998-09-01T23:59:59.000Z

404

Inhibition of X-ray-induced potentially lethal damage (PLD) repair in aerobic plateau-phase Chinese hamster cells by misonidazole  

SciTech Connect (OSTI)

The effect of the 2-nitroimidazole radiosensitizer misonidazole (MISO) and the hydrophilic analog SR-2508 on the repair of X-ray-induced potentially lethal damage (PLD) was studied in plateau-phase Chinese Hamster ovary (HA-1) cells. It was found that although MISO does not radiosensitize aerobic cells, it inhibits the repair of PLD. However, under hypoxic conditions, MISO has no effect on PLD repair. The major portion of the inhibition of PLD repair in aerobic cells requires the presence of MISO only during irradiation; little or no additional inhibition occurs when MISO is present during the postirradiation repair period. Also, treatment of aerobic cells with 5 mM MISO for either 5 or 30 min prior to irradiation is equally inhibitory. This suggests that the presence of MISO in some way modifies the initial lesion under aerobic conditions since it does not increase cell killing as determined by immediate plating but inhibits subsequent repair. The inhibition is concentration dependent; 0.5 mM MISO inhibits PLD repair by one-half while 5-10 mM totally inhibits the repair measured 6 hr postirradiation. This phenomenon suggests that radiosensitization of tissue in vivo by MISO and other 2-nitroimidazoles may not be unequivocal proof of the presence of hypoxic cells.

Brown, D.M.

1984-01-01T23:59:59.000Z

405

Kevin P. Boggs || Office of Technology Transfer || 901.678.1712 || kpboggs@memphis.edu Novel Material Improves and Streamlines Repair of Peripheral Nerves  

E-Print Network [OSTI]

. A significant alternative to suturing peripheral nerve injuries, an aerogel-based implant uniquely destination. "It is my opinion that the development of the multidimensional aerogel based nerve repair device boards, an aerogel-based peripheral nerve repair approach applies the functionality of a circuit board

Dasgupta, Dipankar

406

Abstract--In this paper a novel approach based on mul-ti-robot cooperation is introduced for inspection and repair of  

E-Print Network [OSTI]

-robot system is designed for dome inspection and repair. In this design the robots are connected to each other for inspection and repair of dome structures. In this application, three robots which can be extended to more robot have access to all parts of the dome. The mathematical model of the system is derived

Berns, Karsten

407

Breaking the Ice: Navigation in the Arctic Grace Xingxin Gao, Liang Heng, Todd Walter, and Per Enge  

E-Print Network [OSTI]

Breaking the Ice: Navigation in the Arctic Grace Xingxin Gao, Liang Heng, Todd Walter, and Per Enge (ION) Early Achievement Award. Liang Heng is a Ph.D. candidate under the guidance of Professor Per Enge

Gao, Grace Xingxin

408

TITAN code development for application to a PWR steam line break accident : final report 1983-1984  

E-Print Network [OSTI]

Modification of the TITAN computer code which enables it to be applied to a PWR steam line break accident has been accomplished. The code now has the capability of simulating an asymmetric inlet coolant temperature transient ...

Tsai, Chon-Kwo

1984-01-01T23:59:59.000Z

409

Mass-related inversion symmetry breaking and phonon self-energy renormalization in isotopically labeled AB-stacked bilayer graphene  

E-Print Network [OSTI]

A mass-related symmetry breaking in isotopically labeled bilayer graphene (2LG) was investigated during in-situ electrochemical charging of AB stacked (AB-2LG) and turbostratic (t-2LG) layers. The overlap of the two ...

Araujo, Paulo Antonio Trinidade

410

Introduction of Break-Out Session 2 of the 2011 International PV Module Quality Assurance Forum(Presentation)  

SciTech Connect (OSTI)

This presentation outlines the goals and specific tasks of break-out session 2 of the 2011 International PV Module Quality Assurance Forum, along with a review of accelerated stress tests used for photovoltaics (PV).

Wohlgemuth, J.; Kurtz, S.; Sample, T.; Yamamichi, M.

2011-07-01T23:59:59.000Z

411

Search for Supersymmetry with Gauge-Mediated Breaking in Diphoton Events with Missing Transverse Energy at CDF II  

E-Print Network [OSTI]

We present the results of a search for supersymmetry with gauge-mediated breaking and ?˜[subscript 1][superscript 0]??G˜ in the ??+missing transverse energy final state. In 2.6±0.2??fb[superscript -1] of pp? collisions ...

Bauer, Gerry P.

412

Break-Even Cost for Residential Solar Water Heating in the United States: Key Drivers and Sensitivities  

SciTech Connect (OSTI)

This paper examines the break-even cost for residential rooftop solar water heating (SWH) technology, defined as the point where the cost of the energy saved with a SWH system equals the cost of a conventional heating fuel purchased from the grid (either electricity or natural gas). We examine the break-even cost for the largest 1,000 electric and natural gas utilities serving residential customers in the United States as of 2008. Currently, the break-even cost of SWH in the United States varies by more than a factor of five for both electricity and natural gas, despite a much smaller variation in the amount of energy saved by the systems (a factor of approximately one and a half). The break-even price for natural gas is lower than that for electricity due to a lower fuel cost. We also consider the relationship between SWH price and solar fraction and examine the key drivers behind break-even costs. Overall, the key drivers of the break-even cost of SWH are a combination of fuel price, local incentives, and technical factors including the solar resource location, system size, and hot water draw.

Cassard, H.; Denholm, P.; Ong, S.

2011-02-01T23:59:59.000Z

413

Arellano, Tatum, Stark, Horvath, Leshchinsky 1 Interim Design Guideline for EPS-Block Geofoam in Slope Stabilization and Repair  

E-Print Network [OSTI]

Arellano, Tatum, Stark, Horvath, Leshchinsky 1 Interim Design Guideline for EPS-Block Geofoam of expanded polystyrene (EPS)-block geofoam3 for slope stabilization and repair based on the National for the use of EPS-block geofoam6 for the function of lightweight fill in slope stability applications

414

Diet-dependent survival of protein repair-deficient miceB Christine E. Farrar, Steven ClarkeT  

E-Print Network [OSTI]

Diet-dependent survival of protein repair-deficient miceB Christine E. Farrar, Steven Clarke, and mice lacking this enzyme accumulate damaged proteins in multiple tissues, die at an early age from and in vivo [1­7]. Mice lacking the enzyme (Pcmt1À/À mice) accu- mulate damaged proteins in multiple tissues

Clarke, Steven

415

Genes Involved in DNA Repair and Nitrosamine Metabolism and Those Located on Chromosome 14q32 Are  

E-Print Network [OSTI]

that nitrosa- mine activation and DNA repair are important in NPC. The consistent down-regulation of expression Ahlquist,4,6 and Allan Hildesheim2 1 Biometric Research Branch, Division of Cancer Treatment and Diagnosis and 2 Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics

Newton, Michael

416

A review of "To Repair the Ruins: Reading Milton" edited by Mary C. Fenton and Louis Schwartz  

E-Print Network [OSTI]

that deserve the attention he gives them. Mary C. Fenton and Louis Schwartz, eds. To Repair the Ruins: Reading Milton. Pittsburgh: Duquesne University Press, #18;#17;#16;#18;. xii + #1;#30; pp. + #18;#18; illus. $#14;#15;.#17;#17;. Review by #8...

Welch, Anthony

2013-01-01T23:59:59.000Z

417

Original Full Length Article Inkjet-based biopatterning of SDF-1 augments BMP-2-induced repair of  

E-Print Network [OSTI]

Original Full Length Article Inkjet-based biopatterning of SDF-1 augments BMP-2-induced repair Biopatterning BMP-2 SDF-1 TGF-1 Background: A major problem in craniofacial surgery is non-healing bone defects-derived factor-1 (SDF-1), transforming growth factor-1 (TGF-1), or co-therapies thereof. We tested the hypothesis

Weiss, Lee E.

418

The Effect of Debris on Collector Optics, its Mitigation and Repair: Next-Step a Gaseous Sn EUV DPP Source  

E-Print Network [OSTI]

The Effect of Debris on Collector Optics, its Mitigation and Repair: Next-Step a Gaseous Sn EUV DPP to advanced fuel plasma EUV sources is collector lifetime. The Illinois Debris-mitigation EUV Applications based on this work. Keywords: EUV source, debris, optics, collector lifetime, mitigation, plasma

Spila, Timothy P.

419

Surgical technique, using skin, for repair of simultaneously ruptured anterior cruciate and medial collateral ligaments of the canine femorotibial articulation  

E-Print Network [OSTI]

Agricultural and Mechanical College of Texan In Partial Fulfillnent of the !Iequireaents for the Degree Meeter of Science in Veterinary Medicine and Surgery by Janie Neal Chaetain January 1&359 SURGICAL TECHNI((UE ~ USIN'G SKIN ~ FOR REPAIR...

Chastain, Jamie Neal

1959-01-01T23:59:59.000Z

420

Designer's guidebook for first wall/blanket/shield assembly, maintenance, and repair  

SciTech Connect (OSTI)

This is the initial issue of the guidebook. Since a guidebook of this type must incorporate information concerning a wide range of subjects, much additional data will eventually be included. The guidebook will document, in summary and easily referenceable form, data, designs, design concepts, design guidelines and background information useful to the FWBS and to the Maintenance System designer. In providing guidelines for the AMR of the FWBS, the guidebook must, of necessity, include guidelines for all aspects of maintenance associated with the FWBS. These include most maintenance operations within the reactor room necessary to gain access, identify faults, and handle equipment related to FWBS maintenance. In addition, the guidelines include those required to define facility requirements for handling and repair of FWBS and related reactor components external to the reactor room. Particular emphasis is given to remote maintenance design and operations.

Not Available

1983-12-30T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

THE IMPACT OF BARS ON DISK BREAKS AS PROBED BY S{sup 4}G IMAGING  

SciTech Connect (OSTI)

We have analyzed the radial distribution of old stars in a sample of 218 nearby face-on disks, using deep 3.6 {mu}m images from the Spitzer Survey of Stellar Structure in Galaxies. In particular, we have studied the structural properties of those disks with a broken or down-bending profile. We find that, on average, disks with a genuine single-exponential profile have a scale length and a central surface brightness which are intermediate to those of the inner and outer components of a down-bending disk with the same total stellar mass. In the particular case of barred galaxies, the ratio between the break and the bar radii (R{sub br}/R{sub bar}) depends strongly on the total stellar mass of the galaxy. For galaxies more massive than 10{sup 10} M{sub Sun }, the distribution is bimodal, peaking at R{sub br}/R{sub bar} {approx} 2 and {approx}3.5. The first peak, which is the most populated one, is linked to the outer Lindblad resonance of the bar, whereas the second one is consistent with a dynamical coupling between the bar and the spiral pattern. For galaxies below 10{sup 10} M{sub Sun }, breaks are found up to {approx}10 R{sub bar}, but we show that they could still be caused by resonances given the rising nature of rotation curves in these low-mass disks. While not ruling out star formation thresholds, our results imply that radial stellar migration induced by non-axisymmetric features can be responsible not only for those breaks at {approx}2 R{sub bar}, but also for many of those found at larger radii.

Munoz-Mateos, Juan Carlos; Sheth, Kartik; Kim, Taehyun [National Radio Astronomy Observatory/NAASC, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Gil de Paz, Armando [Departamento de Astrofisica, Universidad Complutense de Madrid, E-28040 Madrid (Spain); Meidt, Sharon [Max-Planck-Institut fuer Astronomie, Koenigstuhl 17, D-69117 Heidelberg (Germany); Athanassoula, E.; Bosma, Albert [Aix Marseille Universite, CNRS, LAM (Laboratoire d'Astrophysique de Marseille) UMR 7326, F-13388 Marseille (France); Comeron, Sebastien; Laine, Jarkko; Laurikainen, Eija [Department of Physical Sciences/Astronomy Division, University of Oulu, FIN-90014 (Finland); Elmegreen, Debra M. [Department of Physics and Astronomy, Vassar College, Poughkeepsie, NY 12604 (United States); Elmegreen, Bruce G. [IBM Research Division, T.J. Watson Research Center, Yorktown Hts., NY 10598 (United States); Erroz-Ferrer, Santiago; Knapen, Johan H. [Instituto de Astrofisica de Canarias, E-38205 La Laguna (Spain); Gadotti, Dimitri A. [European Southern Observatory, Casilla 19001, Santiago 19 (Chile); Hinz, Joannah L. [University of Arizona, 933 N. Cherry Ave, Tucson, AZ 85721 (United States); Ho, Luis C.; Madore, Barry F. [The Observatories, Carnegie Institution of Washington, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Holwerda, Benne [European Space Agency, ESTEC, Keplerlaan 1, 2200-AG, Noordwijk (Netherlands); Jarrett, Thomas H., E-mail: jmunoz@nrao.edu [Astrophysics, Cosmology and Gravity Centre, Department of Astronomy, University of Cape Town, Private Bag X3, Rondebosch 7701 (South Africa); and others

2013-07-01T23:59:59.000Z

422

The role of quantum recurrence in superconductivity, carbon nanotubes and related gauge symmetry breaking  

E-Print Network [OSTI]

Pure quantum phenomena are characterized by intrinsic recurrences in space and time. We use such an intrinsic periodicity as a quantization condition to derive the essential phenomenology of superconductivity. The resulting description is based on fundamental quantum dynamics and geometrical considerations, rather than on microscopical characteristics of the superconducting materials. This allows for the interpretation of the related gauge symmetry breaking by means of the competition between quantum recurrence and thermal noise. We also test the validity of this approach to describe the case of carbon nanotubes.

Donatello Dolce; Andrea Perali

2014-09-29T23:59:59.000Z

423

Non-destructive qualification tests for ITER cryogenic axial insulating breaks  

SciTech Connect (OSTI)

In the ITER superconducting magnets the dielectric separation between the CICC (Cable-In-Conduit Conductors) and the helium supply pipes is made through the so-called insulating breaks (IB). These devices shall provide the required dielectric insulation at a 30 kV level under different types of stresses and constraints: thermal, mechanical, dielectric and ionizing radiations. As part of the R and D program, the ITER Organization launched contracts with industrial companies aimed at the qualification of the manufacturing techniques. After reviewing the main functional aspects, this paper describes and discusses the protocol established for non-destructive qualification tests of the prototypes.

Kosek, Jacek [Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland and CERN, Geneva 23,CH-1211 (Switzerland); Lopez, Roberto; Tommasini, Davide [CERN, Geneva 23,CH-1211 (Switzerland); Rodriguez-Mateos, Felix [CERN, Geneva 23,CH-1211, Switzerland and ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul lez Durance (France)

2014-01-29T23:59:59.000Z

424

A probabilistic method for leak-before-break analysis of CANDU reactor pressure tubes  

SciTech Connect (OSTI)

A probabilistic code for the prediction of the cumulative probability of pressure tube ruptures in CANDU type reactors is described. Ruptures are assumed to result from the axial growth by delayed hydride cracking. The BLOOM code models the major phenomena that affect crack length and critical crack length during the reactor sequence of events following the first indications of leakage. BLOOM can be used to develop unit-specific estimates of the actual probability of pressure rupture in operating CANDU reactors and supplement the existing leak before break analysis.

Puls, M.P.; Wilkins, B.J.S.; Rigby, G.L. [Whiteshell Labs., Pinawa (Canada)] [and others

1997-04-01T23:59:59.000Z

425

TACIS 91: Application of leak-before-break concept in VVER 440-230  

SciTech Connect (OSTI)

The applicability of the leak-before-break (LBB) concept for primary piping in the first generation of WWER type plants in Russia is investigated. The procedures for LBB behavior used in France and Germany are applied, and the evaluation is discussed within the framework of the European Technical Assistance for the Community of Independent States (TACIS) project. Emphasis is placed on experimental validation of national and international engineering practice for evaluating and optimizing existing installations. Design criteria of WWER plants are compared to western standard design.

Bartholome, G.; Faidy, C.; Franco, C. [and others

1997-04-01T23:59:59.000Z

426

Charge independence, charge symmetry breaking in the S-wave nucleon-nucleon interaction, and renormalization  

SciTech Connect (OSTI)

We study the interplay between charge symmetry breaking and renormalization in the NN system for S-waves. We find a set of universality relations which disentangle explicitly the known long distance dynamics from low energy parameters and extend them to the Coulomb case. We analyze within such an approach the One-Boson-Exchange potential and the theoretical conditions which allow to relate the proton-neutron, proton-proton and neutron-neutron scattering observables without the introduction of extra new parameters and providing good phenomenological success.

Alvaro Calle Cordon,Manuel Pavon Valderrama,Enrique Ruiz Arriola

2012-02-01T23:59:59.000Z

427

Generalized mass formula for non-strange and hyper nuclei with SU(6) symmetry breaking  

E-Print Network [OSTI]

A simultaneous description of non-strange nuclei and hypernuclei is provided by a single mass formula inspired by the spin-flavour SU(6) symmetry breaking. This formula is used to estimate the hyperon binding energies of Lambda, double Lambda, Sigma, Cascade and Theta hypernuclei. The results are found to be in good agreement with the available experimental data on 'bound' nuclei and relativistic as well as quark mean field calculations. This mass formula is useful to estimate binding energies over a wide range of masses including the light mass nuclei. It is not applicable for repulsive potential.

C. Samanta; P. Roy Chowdhury; D. N. Basu

2006-01-19T23:59:59.000Z

428

Universal routes to spontaneous PT-symmetry breaking in non-Hermitian quantum systems  

SciTech Connect (OSTI)

PT-symmetric systems can have a real spectrum even when their Hamiltonian is non-Hermitian, but develop a complex spectrum when the degree of non-Hermiticity increases. Here we utilize random-matrix theory to show that this spontaneous PT-symmetry breaking can occur via two distinct mechanisms, whose predominance is associated to different universality classes. Present optical experiments fall into the orthogonal class, where symmetry-induced level crossings render the characteristic absorption rate independent of the coupling strength between the symmetry-related parts of the system.

Schomerus, Henning [Department of Physics, Lancaster University, Lancaster LA1 4YB (United Kingdom)

2011-03-15T23:59:59.000Z

429

Replica Symmetry Breaking in the Intensity Fluctuation Overlap of Random Laser Emission Spectra  

E-Print Network [OSTI]

We report about a newly introduced overlap parameter of intensity fluctuations of waves in random media with arbitrary amount of disorder and non-linearity and its relationship to the replica theory overlap in the $2+4$ spherical complex spin-glass model. Symmetry breaking in the intensity fluctuation overlap is shown to be equivalent to the one occurring in the complex amplitude overlap, providing an easily verifiable test in typical experimental setups. The relevance of this order parameter is considered in describing the laser transition in random media and in explaining its glassy nature in terms of emission spectra data. The theoretical analysis is compared to recent measurements.

Antenucci, Fabrizio; Leuzzi, Luca

2015-01-01T23:59:59.000Z

430

NNSA Breaks Ground on Tritium Facilities at SRS | National Nuclear Security  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas Conchas recovery challengeMultiscaleLogos NERSCJeffreyKeyAdministration Breaks Ground on

431

Breaking Ground and Driving Discovery | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched5 Industrial CarbonArticlesHumanJune 2008 Basic EnergyB.Bette Korber, 2004Breaking

432

EECBG Success Story: Breaking Ground in Miami-Dade | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeat Pump Models |Conduct,Final9: DraftPlant,Community' | Department ofSensorsBreaking

433

Bubbles Help Break Energy Storage Record for Lithium Air-Batteries  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone6Energy, science, and technology for theBubbles Help Break

434

Novel Thermal Break with Simplified Manufacturing for R7 Commercial Windows  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion | Department ofT ib l L d F S iPartnershipEnergy| Department of Energy Thermal Break

435

THE KINEMATICS OF IONIZED GAS IN LYMAN-BREAK ANALOGS AT z {approx} 0.2  

SciTech Connect (OSTI)

We present results for 19 'Lyman-break analogs' observed with Keck/OSIRIS with an adaptive-optics-assisted spatial resolution of less than 200 pc. We detect satellites/companions, diffuse emission, and velocity shear, all with high signal-to-noise ratios. These galaxies present remarkably high velocity dispersion along the line of sight ({approx}70 km s{sup -1}), much higher than standard star-forming spirals in the low-redshift universe. We artificially redshift our data to z {approx} 2.2 to allow for a direct comparison with observations of high-z Lyman-break galaxies and find striking similarities between both samples. This suggests that either similar physical processes are responsible for their observed properties, or, alternatively, that it is very difficult to distinguish between different mechanisms operating in the low- versus high-redshift starburst galaxies based on the available data. The comparison between morphologies in the UV/optical continuum and our kinemetry analysis often shows that neither is by itself sufficient to confirm or completely rule out the contribution from recent merger events. We find a correlation between the kinematic properties and stellar mass, in that more massive galaxies show stronger evidence for a disk-like structure. This suggests a co-evolutionary process between the stellar mass buildup and the formation of morphological and dynamical substructure within the galaxy.

Goncalves, Thiago S.; Martin, D. Christopher; Wyder, Ted K. [California Institute of Technology, MC 278-17, Pasadena, CA 91125 (United States); Basu-Zych, Antara [NASA Goddard Space Flight Center, Laboratory for X-ray Astrophysics, Greenbelt, MD 20771 (United States); Overzier, Roderik [Max-Planck-Institut fuer Astrophysik, D-85748 Garching (Germany); Law, David R.; Mallery, Ryan; Rich, R. Michael [Department of Physics and Astronomy, Division of Astronomy and Astrophysics, University of California, Los Angeles, CA 90095 (United States); Schiminovich, David [Department of Astronomy, Columbia University, MC 2457, 550 West 120th Street, New York, NY 10027 (United States); Heckman, Timothy H., E-mail: tsg@astro.caltech.ed [Department of Physics and Astronomy, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States)

2010-12-01T23:59:59.000Z

436

Leak before break evaluation for main steam piping system made of SA106 Gr.C  

SciTech Connect (OSTI)

The basis of the leak before break (LBB) concept is to demonstrate that piping will leak significantly before a double ended guillotine break (DEGB) occurs. This is demonstrated by quantifying and evaluating the leak process and prescribing safe shutdown of the plant on the basis of the monitored leak rate. The application of LBB for power plant design has reduced plant cost while improving plant integrity. Several evaluations employing LBB analysis on system piping based on DEGB design have been completed. However, the application of LBB on main steam (MS) piping, which is LBB applicable piping, has not been performed due to several uncertainties associated with occurrence of steam hammer and dynamic strain aging (DSA). The objective of this paper is to demonstrate the applicability of the LBB design concept to main steam lines manufactured with SA106 Gr.C carbon steel. Based on the material properties, including fracture toughness and tensile properties obtained from the comprehensive material tests for base and weld metals, a parametric study was performed as described in this paper. The PICEP code was used to determine leak size crack (LSC) and the FLET code was used to perform the stability assessment of MS piping. The effects of material properties obtained from tests were evaluated to determine the LBB applicability for the MS piping. It can be shown from this parametric study that the MS piping has a high possibility of design using LBB analysis.

Yang, Kyoung Mo; Jee, Kye Kwang; Pyo, Chang Ryul; Ra, In Sik [Korea Power Engineering Company, Seoul (Korea, Republic of)

1997-04-01T23:59:59.000Z

437

On the breaking of a plasma wave in a thermal plasma. I. The structure of the density singularity  

SciTech Connect (OSTI)

The structure of the singularity that is formed in a relativistically large amplitude plasma wave close to the wave breaking limit is found by using a simple waterbag electron distribution function. The electron density distribution in the breaking wave has a typical 'peakon' form. The maximum value of the electric field in a thermal breaking plasma is obtained and compared to the cold plasma limit. The results of computer simulations for different initial electron distribution functions are in agreement with the theoretical conclusions. The after-wavebreak regime is then examined, and a semi-analytical model of the density evolution is constructed. Finally the results of two dimensional particle in cell simulations for different initial electron distribution functions are compared, and the role of thermal effects in enhancing particle injection is noted.

Bulanov, Sergei V.; Esirkepov, Timur Zh.; Kando, Masaki; Koga, James K.; Pirozhkov, Alexander S.; Nakamura, Tatsufumi [QuBS, Japan Atomic Energy Agency, 1-8-7 Umemidai, Kizugawa, Kyoto 619-0215 (Japan); Bulanov, Stepan S. [University of California, Berkeley, California 94720 (United States); Schroeder, Carl B.; Esarey, Eric [Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Califano, Francesco; Pegoraro, Francesco [Physics Department, University of Pisa, Pisa 56127 (Italy)

2012-11-15T23:59:59.000Z

438

GeV BREAKS IN BLAZARS AS A RESULT OF GAMMA-RAY ABSORPTION WITHIN THE BROAD-LINE REGION  

SciTech Connect (OSTI)

Spectra of the brightest blazars detected by the Fermi Gamma-ray Space Telescope Large Area Telescope cannot be described by a simple power-law model. A much better description is obtained with a broken power law, with the break energies of a few GeV. We show here that the sharpness and the position of the breaks can be well reproduced by absorption of {gamma}-rays via photon-photon pair production on He II Lyman recombination continuum and lines. This implies that the blazar zone lies inside the region of the highest ionization of the broad-line region (BLR) within a light-year from a super-massive black hole. The observations of {gamma}-ray spectral breaks open a way of studying the BLR photon field in the extreme-UV/soft X-rays, which are otherwise hidden from our view.

Poutanen, Juri; Stern, Boris, E-mail: juri.poutanen@oulu.f, E-mail: boris.stern@gmail.co [Astronomy Division, Department of Physics, P.O. Box 3000, 90014 University of Oulu, Oulu (Finland)

2010-07-10T23:59:59.000Z

439

Engineering Endostatin-Producing Cartilaginous Constructs for Cartilage Repair Using Nonviral Transfection of Chondrocyte-Seeded and Mesenchymal-Stem-Cell-Seeded Collagen Scaffolds  

E-Print Network [OSTI]

Although there is widespread recognition of the importance of angiogenesis in tissue repair, there is little work on the inhibition of angiogenesis in the context of tissue engineering of naturally avascular tissues, like ...

Jeng, Lily

440

The behavior of ANGRA 2 nuclear power plant core for a small break LOCA simulated with RELAP5 code  

SciTech Connect (OSTI)

This work discusses the behavior of Angra 2 nuclear power plant core, for a postulate Loss of Coolant Accident (LOCA) in the primary circuit for Small Break Loss Of Coolant Accident (SBLOCA). A pipe break of the hot leg Emergency Core Cooling System (ECCS) was simulated with RELAP 5 code. The considered rupture area is 380 cm{sup 2}, which represents 100% of the ECCS pipe flow area. Results showed that the cooling is enough to guarantee the integrity of the reactor core.

Sabundjian, Gaiane; Andrade, Delvonei A.; Belchior, Antonio Jr.; Silva Rocha, Marcelo da; Conti, Thadeu N.; Torres, Walmir M.; Macedo, Luiz A.; Umbehaun, Pedro E.; Mesquita, Roberto N.; Masotti, Paulo H. F.; Souza Lima, Ana Cecilia de [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN - SP) Av. Professor Lineu Prestes, 2242 05508-000 Sao Paulo, SP (Brazil)

2013-05-06T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Edge of chaos as critical local symmetry breaking in dissipative nonautonomous systems  

E-Print Network [OSTI]

The fully nonlinear notion of resonance -$\\textit{geometrical resonance}$- in the general context of dissipative systems subjected to $\\textit{nonsteady}$ potentials is discussed. It is demonstrated that there is an exact local invariant associated with each geometrical resonance solution which reduces to the system's energy when the potential is steady. The geometrical resonance solutions represent a \\textit{local symmetry} whose critical breaking leads to a new analytical criterion for the order-chaos threshold. This physical criterion is deduced in the co-moving frame from the local energy conservation over the shortest significant timescale. Remarkably, the new criterion for the onset of chaos is shown to be valid over large regions of parameter space, thus being useful beyond the perturbative regime and the scope of current mathematical techniques.

Ricardo Chacón

2015-04-08T23:59:59.000Z

442

Symmetry breaking for ratchet transport in presence of interactions and magnetic field  

E-Print Network [OSTI]

We study the microwave induced ratchet transport of two-dimensional electrons on an oriented semidisk Galton board. The magnetic field symmetries of ratchet transport are analyzed in presence of electron-electron interactions. Our results show that a magnetic field asymmetric ratchet current can appear due to two contributions, a Hall drift of the rectified current that depends only weakly on electron-electron interactions and a breaking of the time reversal symmetry due to the combined effects of interactions and magnetic field. In the latter case, the asymmetry between positive and negative magnetic fields vanishes in the weak interaction limit. We also discuss the recent experimental results on ratchet transport in asymmetric nanostructures.

Leonardo Ermann; Alexei D. Chepelianskii; Dima L. Shepelyansky

2012-11-19T23:59:59.000Z

443

Critical Dynamics of Spontaneous Symmetry Breaking in a Homogeneous Bose gas  

E-Print Network [OSTI]

We explore the dynamics of spontaneous symmetry breaking in a homogeneous system by thermally quenching an atomic gas with short-range interactions through the Bose-Einstein phase transition. Using homodyne matter-wave interferometry to measure first-order correlation functions, we verify the central quantitative prediction of the Kibble-Zurek theory, namely the homogeneous-system power-law scaling of the coherence length with the quench rate. Moreover, we directly confirm its underlying hypothesis, the freezing of the correlation length near the transition due to critical slowing down. Our measurements agree with beyond mean-field theory, and support the previously unverified expectation that the dynamical critical exponent for this universality class, which includes the $\\lambda$-transition of liquid $^4$He, is $z=3/2$.

Nir Navon; Alexander L. Gaunt; Robert P. Smith; Zoran Hadzibabic

2014-10-30T23:59:59.000Z

444

General relativity as the effective theory of GL(4,R) spontaneous symmetry breaking  

SciTech Connect (OSTI)

We assume a GL(4,R) space-time symmetry which is spontaneously broken to SO(3,1). We carry out the coset construction of the effective theory for the nonlinearly realized broken symmetry in terms of the Goldstone fields and matter fields transforming linearly under the unbroken Lorentz subgroup. We then identify functions of the Goldstone and matter fields that transform linearly also under the broken symmetry. Expressed in terms of these quantities the effective theory reproduces the vierbein formalism of general relativity with general coordinate invariance being automatically realized nonlinearly over GL(4,R). The coset construction makes no assumptions about any underlying theory that might be responsible for the assumed symmetry breaking. We give a brief discussion of the possibility of field theories with GL(4,R) rather than Lorentz space-time symmetry providing the underlying dynamics.

Tomboulis, E. T. [Department of Physics and Astronomy, UCLA, Los Angeles, California 90095-1547 (United States)

2011-10-15T23:59:59.000Z

445

General Relativity as the effective theory of GL(4,R) spontaneous symmetry breaking  

E-Print Network [OSTI]

We assume a GL(4,R) space-time symmetry which is spontaneously broken to SO(3,1). We carry out the coset construction of the effective theory for the non-linearly realized broken symmetry in terms of the Goldstone fields and matter fields transforming linearly under the unbroken Lorentz subgroup. We then identify functions of the Goldstone and matter fields that transform linearly also under the broken symmetry. Expressed in terms of these quantities the effective theory reproduces the vierbein formalism of General Relativity with general coordinate invariance being automatically realized non-linearly over GL(4,R). The coset construction makes no assumptions about any underlying theory that might be responsible for the assumed symmetry breaking. We give a brief discussion of the possibility of field theories with GL(4,R) rather than Lorentz space-time symmetry providing the underlying dynamics.

E. T. Tomboulis

2011-05-30T23:59:59.000Z

446

Chiral-Symmetry Breaking in Pseudo Quantum Electrodynamics at Finite Temperature  

E-Print Network [OSTI]

We use the Schwinger-Dyson equations in the presence of a thermal bath, in order to study chiral symmetry breaking in a system of massless Dirac fermions interacting through pseudo quantum electrodynamics (PQED3), in (2+1) dimensions. We show that there is a critical temperature $T_c$, below which chiral symmetry is broken, and a corresponding mass gap is dynamically generated, provided the coupling is above a certain, temperature dependent, critical value $\\alpha_c$. The ratio between the energy gap and the critical temperature for this model is estimated to be $2 \\pi$. These results are confirmed by analytical and numerical investigations of the Schwinger-Dyson equation for the electron. In addition, we calculate the first finite-temperature corrections to the static Coulomb interaction. The relevance of this result in the realm of condensed matter systems, like graphene, is briefly discussed.

Leandro O. Nascimento; Van Sérgio Alves; Francisco Peña; C. Morais Smith; E. C. Marino

2015-03-28T23:59:59.000Z

447

Evidence of BRST-Symmetry Breaking in Lattice Minimal Landau Gauge  

E-Print Network [OSTI]

By evaluating the so-called Bose-ghost propagator, we present the first numerical evidence of BRST-symmetry breaking for Yang-Mills theory in minimal Landau gauge, i.e. due to the restriction of the functional integration to the first Gribov region in the Gribov-Zwanziger approach. Our data are well described by a simple fitting function, which can be related to a massive gluon propagator in combination with an infrared-free (Faddeev-Popov) ghost propagator. As a consequence, the Bose-ghost propagator, which has been proposed as a carrier of the confining force in minimal Landau gauge, displays a 1/p^4 singularity in the infrared limit.

Attilio Cucchieri; David Dudal; Tereza Mendes; Nele Vandersickel

2014-10-30T23:59:59.000Z

448

Practical applications of the R6 leak-before-break procedure  

SciTech Connect (OSTI)

A forthcoming revision to the R6 Leak-before-Break Assessment Procedure is briefly described. Practical application of the LbB concepts to safety-critical nuclear plant is illustrated by examples covering both low temperature and high temperature (>450{degrees}C) operating regimes. The examples highlight a number of issues which can make the development of a satisfactory LbB case problematic: for example, coping with highly loaded components, methodology assumptions and the definition of margins, the effect of crack closure owing to weld residual stresses, complex thermal stress fields or primary bending fields, the treatment of locally high stresses at crack intersections with free surfaces, the choice of local limit load solution when predicting ligament breakthrough, and the scope of calculations required to support even a simplified LbB case for high temperature steam pipe-work systems.

Bouchard, P.J.

1997-04-01T23:59:59.000Z

449

Specialist meeting on leak before break in reactor piping and vessels  

SciTech Connect (OSTI)

A series of research projects sponsored by the Federal Minister for Education, Science, Research and Technology, Bonn are summarized and compared to utility, manufacturer, and vendor tests. The purpose of the evaluation was to experimentally verify Leak-before-Break behavior, confirm the postulation of fracture preclusion for piping (straight pipe, bends and branches), and quantify the safety margin against massive failure. The results are applicable to safety assessment of ferritic and austenitic piping in primary and secondary nuclear power plant circuits. Moreover, because of the wide range of the test parameters, they are also important for the design and assessment of piping in other technical plant. The test results provide justification for ruling out catastrophic fractures, even on pipes of dimensions corresponding to those of a main coolant pipe of a pressurized water reactor plant on the basis of a mechanical deterministic safety analysis in correspondence with the Basis Safety Concept (Principle of Fracture Exclusion).

Bartholome, G.; Bazant, E.; Wellein, R. [Siemens KWU, Stuttgart (Germany)] [and others

1997-04-01T23:59:59.000Z

450

Spontaneous breaking of symmetry of the gravitons of the long wave spectrum in the early Universe  

E-Print Network [OSTI]

It is shown that nonlinear terms in equations of gravitons on the background of curved space-time of the expanding Universe can solve the problem of the negative square of the effective mass formally arising in linear approximation for gravitons. Similar to well known spontaneous breaking of symmetry in Goldstone model one must take another vacuum so that nonzero vacuum expectation value of the quantized graviton field leads to change of spectrum for gravitons. There appears two graviton fields, one with the positive mass, another with the zero mass. Energy density and the density of particles created by gravitation of the expanding Universe are calculated for some special cases of the scale factor. Numerical of result are obtained for the dust universe case.

A. A. Grib

2009-05-07T23:59:59.000Z

451

Order statistics inference for describing topological coupling and mechanical symmetry breaking in multidomain proteins  

E-Print Network [OSTI]

Cooperativity is a hallmark of proteins, many of which show a modular architecture comprising discrete structural domains. Detecting and describing dynamic couplings between structural regions is difficult in view of the many-body nature of protein-protein interactions. By utilizing the GPU-based computational acceleration, we carried out simulations of the protein forced unfolding for the dimer WW-WW of the all-beta-sheet WW domains used as a model multidomain protein. We found that while the physically non-interacting identical protein domains (WW) show nearly symmetric mechanical properties at low tension, reflected, e.g., in the similarity of their distributions of unfolding times, these properties become distinctly different when tension is increased. Moreover, the uncorrelated unfolding transitions at a low pulling force become increasingly more correlated (dependent) at higher forces. Hence, the applied force not only breaks "the mechanical symmetry" but also couples the physically non-interacting prot...

Kononova, Olga; Barsegov, Valeri

2015-01-01T23:59:59.000Z

452

Autonomous Motility of Active Filaments due to Spontaneous Flow-Symmetry Breaking  

E-Print Network [OSTI]

We simulate the nonlocal Stokesian hydrodynamics of an elastic filament which is active due a permanent distribution of stresslets along its contour. A bending instability of an initially straight filament spontaneously breaks flow symmetry and leads to autonomous filament motion which, depending on conformational symmetry, can be translational or rotational. At high ratios of activity to elasticity, the linear instability develops into nonlinear fluctuating states with large amplitude deformations. The dynamics of these states can be qualitatively understood as a superposition of translational and rotational motion associated with filament conformational modes of opposite symmetry. Our results can be tested in molecular-motor filament mixtures, synthetic chains of autocatalytic particles, or other linearly connected systems where chemical energy is converted to mechanical energy in a fluid environment.

Gayathri Jayaraman; Sanoop Ramachandran; Somdeb Ghose; Abhrajit Laskar; M. Saad Bhamla; P. B. Sunil Kumar; R. Adhikari

2012-10-10T23:59:59.000Z

453

Spatio-temporal evolution and breaking of double layers: A description using Lagrangian hydrodynamics  

SciTech Connect (OSTI)

The nonlinear development and collapse (breaking) of double layers in the long scale length limit is well described by equations for the cold ion fluid with quasineutrality. It is shown that electron dynamics is responsible for giving an 'equation of state' with negative ratio of specific heats to this fluid. Introducing a transformation for the density variable, the governing equation for the transformed quantity in terms of Lagrange variables turns out exactly to be a linear partial differential equation. This equation has been analyzed in various limits of interest. Nonlinear development of double layers with a sinusoidal initial disturbance and collapse of double layers with an initial perturbation in the form of a density void are analytically investigated.

Kaw, Predhiman; Sengupta, Sudip; Singh Verma, Prabal [Institute for Plasma Research, Bhat, Gandhinagar 382 428 (India)

2012-10-15T23:59:59.000Z

454

Review of In-Service Inspection and Repair Technique Developments for French Liquid Metal Fast Reactors  

SciTech Connect (OSTI)

In-service monitoring of nuclear plants is indispensable for both the Operator and the Regulator. The notion of in-service monitoring ranges from the continuous monitoring of the reactor in operation to the thorough in-service reactor inspection during programmed shutdowns. However, the highly specific environment found in French liquid metal fast reactor plants - Phenix and Superphenix - makes monitoring and inspection complicated because of the use of a sodium coolant that is hot, opaque, and difficult to drain.The Commissariat a l'Energie Atomique, in collaboration with its traditional French partners, Electricite de France utilities and FRAMATOME/Novatome Engineering, decided to conduct a 6-yr research and development program (1994-2000) to explore this problem vis-a-vis Superphenix, as well as the possibilities of intervening within the reactor block or on components in a sodium environment. Furthermore, the safety reevaluation of Phenix, conducted between 1994 and 2003, represented an excellent 'test bench' during which the limits of inspection processes - applied to an integrated reactor concept - were surpassed using techniques such as fuel subassembly head scanning, ultrasonic examination of the core support, and visual inspection of the cover-gas plenum following a partial sodium draining. Repair techniques were investigated for cleaning of sodium wet structure surfaces, cutting of damaged parts, and welding in sodium aerosol atmosphere. Both conventional and laser processes were tested.

Baque, F. [Commissariat a l'Energie Atomique Cadarache (France)

2005-04-15T23:59:59.000Z

455

Evaluating indoor exposure modeling alternatives for LCA: A case study in the vehicle repair industry  

SciTech Connect (OSTI)

We evaluated three exposure models with data obtained from measurements among workers who use"aerosol" solvent products in the vehicle repair industry and with field experiments using these products to simulate the same exposure conditions. The three exposure models were the: 1) homogeneously-mixed-one-box model, 2) multi-zone model, and 3) eddy-diffusion model. Temporally differentiated real-time breathing zone volatile organic compound (VOC) concentration measurements, integrated far-field area samples, and simulated experiments were used in estimating parameters, such as emission rates, diffusivity, and near-field dimensions. We assessed differences in model input requirements and their efficacy for predictive modeling. The One-box model was not able to resemble the temporal profile of exposure concentrations, but it performed well concerning time-weighted exposure over extended time periods. However, this model required an adjustment for spatial concentration gradients. Multi-zone models and diffusion-models may solve this problem. However, we found that the reliable use of both these models requires extensive field data to appropriately define pivotal parameters such as diffusivity or near-field dimensions. We conclude that it is difficult to apply these models for predicting VOC exposures in the workplace. However, for comparative exposure scenarios in life-cycle assessment they may be useful.

Demou, Evangelia; Hellweg, Stefanie; Wilson, Michael P.; Hammond, S. Katharine; McKone, Thomas E.

2009-05-01T23:59:59.000Z

456

Accelerated search kinetics mediated by redox reactions of DNA repair enzymes  

E-Print Network [OSTI]

A Charge Transport (CT) mechanism has been proposed in several papers (e.g., Yavin, et al. PNAS, v102 3546 (2005)) to explain the localization of Base Excision Repair (BER) enzymes to lesions on DNA. The CT mechanism relies on redox reactions of iron-sulfur cofactors that modify the enzyme's binding affinity. These redox reactions are mediated by the DNA strand and involve the exchange of electrons between BER enzymes along DNA. We propose a mathematical model that incorporates enzyme binding/unbinding, electron transport, and enzyme diffusion along DNA. Analysis of our model within a range of parameter values suggests that the redox reactions can increase desorption of BER enzymes not already bound to their targets, allowing the enzymes to be recycled, thus accelerating the overall search process. This acceleration mechanism is most effective when enzyme copy numbers and enzyme diffusivity along the DNA are small. Under such conditions, we find that CT BER enzymes find their targets more quickly than simple "passive" enzymes that simply attach to the DNA without desorbing.

Pak-Wing Fok; Tom Chou

2009-05-20T23:59:59.000Z

457

Warm wave breaking of nonlinear plasma waves with arbitrary phase velocities C. B. Schroeder, E. Esarey, and B. A. Shadwick  

E-Print Network [OSTI]

Warm wave breaking of nonlinear plasma waves with arbitrary phase velocities C. B. Schroeder, E, collisionless plasma is developed to analyze nonlinear plasma waves excited by intense drive beams. The maximum amplitude and wavelength are calculated for nonrelativistic plasma temperatures and arbitrary plasma wave

Geddes, Cameron Guy Robinson

458

New LM Unit Root Tests in the Presence of a Possible Break of Unknown Date and Size  

E-Print Network [OSTI]

New LM Unit Root Tests in the Presence of a Possible Break of Unknown Date and Size John T. Cuddington and Shuichiro Nishioka December 6, 2005 Abstract: Lagrange Multiplier (LM) unit root tests performs poorly when used in LM unit root tests and propose an alternative procedure that uses the sup

459

TabletopAccelerator Breaks`Cold Fusion'Jinx ButWon'tYield Energy,Physicists Say  

E-Print Network [OSTI]

TabletopAccelerator Breaks`Cold Fusion'Jinx ButWon'tYield Energy,Physicists Say A crystal with a strange property is at the heart of a clever method for inducing nuclear fusion in a tabletop-sized device-rays for medical therapies. Although the field of room-temperature fusion is littered with scandals and dubious

460

LED Light Fixture Project FC1 Director's Conference Room: Life Cycle Cost and Break-even Analysis  

E-Print Network [OSTI]

. A light-emitting diode (LED) is a solid-state lighting source that switches on instantly, is readilyLED Light Fixture Project ­ FC1 Director's Conference Room: Life Cycle Cost and Break-even Analysis light fixtures in existing or new buildings across campus. Scope of Work On August 27, 2012, the six

Johnston, Daniel

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Forecasting the conditional volatility of oil spot and futures prices with structural breaks and long memory models  

E-Print Network [OSTI]

Forecasting the conditional volatility of oil spot and futures prices with structural breaks of oil spot and futures prices using three GARCH-type models, i.e., linear GARCH, GARCH with structural that oil price fluctuations influence economic activity and financial sector (e.g., Jones and Kaul, 1996

Paris-Sud XI, Université de

462

Active methane venting observed at giant pockmarks along the U.S. mid-Atlantic shelf break  

E-Print Network [OSTI]

Active methane venting observed at giant pockmarks along the U.S. mid-Atlantic shelf break Kori R the edge of the mid-Atlantic continental shelf confirms that methane is actively venting at the site. Dissolved methane concentrations, which were measured with a commercially available methane sensor (METS

Eustice, Ryan

463

JET BREAKS IN SHORT GAMMA-RAY BURSTS. I. THE UNCOLLIMATED AFTERGLOW OF GRB 050724 Dirk Grupe,1  

E-Print Network [OSTI]

JET BREAKS IN SHORT GAMMA-RAY BURSTS. I. THE UNCOLLIMATED AFTERGLOW OF GRB 050724 Dirk Grupe,1 the results of the Chandra observations of the Swift-discovered short gamma-ray burst GRB 050724. Chandra corrected energy of GRB 050724 is at least 4 ; 1049 ergs. Subject headinggs: gamma rays: bursts -- X-rays

Zhang, Bing

464

Hydrogen Bond Breaking and Reformation in Alcohol Oligomers Following Vibrational Relaxation of a Non-Hydrogen-Bond Donating Hydroxyl Stretch  

E-Print Network [OSTI]

Hydrogen Bond Breaking and Reformation in Alcohol Oligomers Following Vibrational Relaxation of a Non-Hydrogen-Bond Donating Hydroxyl Stretch K. J. Gaffney, I. R. Piletic, and M. D. Fayer* Department measured with ultrafast infrared pump-probe experiments. Non-hydrogen-bond donating OD stretches (2690 cm-1

Fayer, Michael D.

465

2/1/2014 Financial Press -Breaking Business & Economic News http://financialpress.com/2014/01/21/teeny-tiny-windmills-could-recharge-phones/ 1/6  

E-Print Network [OSTI]

2/1/2014 Financial Press - Breaking Business & Economic News http://financialpress.com/2014 Twitter Facebook Google #12;2/1/2014 Financial Press - Breaking Business & Economic News http fit on a single grain of rice), can harvest energy from the movement of air. They are the work

Chiao, Jung-Chih

466

Double Beta Decay, Lepton Flavour Violation and Collider Signatures of Left-Right Symmetric Models with Spontaneous D Parity Breaking  

E-Print Network [OSTI]

We propose a class of left-right symmetric models (LRSMs) with spontaneous D parity breaking, where SU(2)_R breaks at the TeV scale while discrete left-right symmetry breaks around 10^9 GeV. By embedding this framework in a non-supersymmetric SO(10) Grand Unified Theory (GUT) with Pati-Salam symmetry as the highest intermediate breaking step, we obtain g_R / g_L ~ 0.6 between the right- and left-handed gauge couplings at the TeV scale. This leads to a suppression of beyond the Standard Model phenomena induced by the right-handed gauge coupling. Here we focus specifically on the consequences for neutrinoless double beta decay, low energy lepton flavour violation and LHC signatures due to the suppressed right handed currents. Interestingly, the reduced g_R allows us to interpret an excess of events observed recently in the range of 1.9 TeV to 2.4 TeV by the CMS group at the LHC as the signature of a right handed gauge boson in LRSMs with spontaneous D parity breaking. Moreover, the reduced right-handed gauge coupling also strongly suppresses the non-standard contribution of heavy states to the neutrinoless double beta decay rate as well as the amplitude of low energy lepton flavour violating processes. In a dominant type-II Seesaw mechanism of neutrino mass generation, we find that both sets of observables provide stringent and complimentary bounds which make it challenging to observe the scenario at the LHC.

Frank F. Deppisch; Tomas E. Gonzalo; Sudhanwa Patra; Narendra Sahu; Utpal Sarkar

2014-10-23T23:59:59.000Z

467

Large Diameter Limbs for Dilated Common Iliac Arteries in Endovascular Aneurysm Repair. Is It Safe?  

SciTech Connect (OSTI)

In this prospective study we examined whether dilated common iliac arteries (CIAs) can provide a safe distal seal in endovascular aneurysm repair (EVAR) with the use of bifurcated stent grafts with large diameter limbs. Sixteen patients with 26 dilated CIAs with a diameter of {>=}6 mm who were offered EVAR using stent grafts with large diameter limbs were included in the study (Group A). Forty-two patients who also underwent EVAR without iliac dilatation, matched for age, sex and surgical risk were used for comparison (controls-Group B). In group A mean CIA diameter was 18.2 mm (16-28) and mean abdominal aortic aneurysm (AAA) diameter was 6.87 {+-} 1.05 cm; mean age was 77.2 {+-} 4.8 yrs (67-81). Mean follow-up was 33.6 months (2.8 yrs). CIA diameter changes and development of endoleaks were assessed by CT angiography (CTA). Overall iliac dilatation was present in 16/58 of our patients (27.6%). In 10 patients dilatation was bilateral (17.3%). Partial or complete flow to the internal iliac artery (IIA) territories was preserved in all patients post-EVAR. On follow-up, stable caliber of the dilated CIAs was observed in 21 patients (84%), enlargement of 1mm in 3 (16%), and failure of the distal attachment in 1 (6.2%). Compared to the control group there was no statistical significance in the incidence of complications. Dilated common iliac arteries provide a safe distal seal in patients who have undergone EVAR, thus obviating the need for additional endovascular procedures and sparing flow in the IIA vascular bed.

Malagari, Katerina, E-mail: kmalag@aias.gr; Brountzos, Elias; Gougoulakis, Alexandros; Papathanasiou, Matilda; Alexopoulou, Efthymia; Mastorakou, Renata; Kelekis, Dimitris [University of Athens, 2nd Department of Radiology (Greece)

2004-09-15T23:59:59.000Z

468

Identification of Intrinsic Order and Disorder in the DNA Repair Protein XPA  

SciTech Connect (OSTI)

The damage recognition protein XPA is required to recognize a wide variety of bulky lesions during nucleotide excision repair (NER). Independent NMR solution structures of a human XPA protein (hXPA) fragment comprising approximately one-third of the full-length protein, the minimal DNA-binding domain (MBD), revealed that ~30% of the molecule was structurally disordered. To better characterize structural features of XPA, we performed time-resolved trypsin proteolysis on active, full-length recombinant Xenopus XPA protein (xXPA). The resulting proteolytic fragments were analyzed by electrospray ionization interface coupled to a Fourier transform ion cyclotron resonance (ESI-FTICR) mass spectrometry, SDS-polyacrylamide gel electrophoresis (PAGE), and selected N-terminal sequence determinations. The mass spectrum of the full-length xXPA was consistent with the predicted sequence, 30922.02 vs. 30922.45 Da; respectively. Moreover, the mass spectrometric data allowed the assignment of multiple xXPA fragments not resolvable by SDS PAGE. Full-length xXPA exhibited aberrant mobility on SDS-PAGE with an apparent MW of ~40 kDa. To test predictions that a Glu-rich region (E70-E76) or other local regions of high charge were responsible for this ~40% aberrant SDS-PAGE mobility, the MW's of partial proteolytic fragments from ~5 to 25 kDa precisely determined by ESI-FTICR MS were correlated with their gel positions. Surprisingly, all tested partial tryptic fragments within this size-range exhibited 10-42% divergence between calculated MW and that estimated by SDS-PAGE, thus indicating the origin of anomalous migration of XPA is not localized. The computer program Predictor of Natural Disordered Regions (PONDR) correctly identified several regions of xXPA either sensitive or resistant to partial proteolysis, thereby indicating that disorder in XPA shares sequence features with other well-characterized intrinsically unstructured proteins.

Iakoucheva, Lilia M.; Kimzey, Amy L.; Masselon, Christophe D.; Bruce, James E.; Garner, Ethan C.; Brown, Celeste J.; Dunker, A. K.; Smith, Richard D.; Ackerman, Eric J.

2001-03-01T23:59:59.000Z

469

A lead-before-break strategy for primary heat transport piping of 500 MWe Indian PHWR  

SciTech Connect (OSTI)

Leak-Before-Break (LBB) is being used to design the primary heat transport piping system of 500 MWe Indian Pressurized Heavy Water Reactors (IPHWR). The work is categorized in three directions to demonstrate three levels of safety against sudden catastrophic break. Level 1 is inherent in the design procedure of piping system as per ASME Sec.III with a well defined factor of safety. Level 2 consists of fatigue crack growth study of a postulated part-through flaw at the inside surface of pipes. Level 3 is stability analysis of a postulated leakage size flaw under the maximum credible loading condition. Developmental work related to demonstration of level 2 and level 3 confidence is described in this paper. In a case study on fatigue crack growth on PHT straight pipes for level 2, negligible crack growth is predicted for the life of the reactor. For level 3 analysis, the R6 method has been adopted. A database to evaluate SIF of elbows with throughwall flaws under combined internal pressure and bending moment has been generated to provide one of the inputs for R6 method. The methodology of safety assessment of elbow using R6 method has been demonstrated for a typical pump discharge elbow. In this analysis, limit load of the cracked elbow has been determined by carrying out elasto-plastic finite element analysis. The limit load results compared well with those given by Miller. However, it requires further study to give a general form of limit load solution. On the experimental front, a set of small diameter pipe fracture experiments have been carried out at room temperature and 300{degrees}C. Two important observations of the experiments are - appreciable drop in maximum load at 300{degrees}C in case of SS pipes and out-of-plane crack growth in case of CS pipes. Experimental load deflection curves are finally compared with five J-estimation schemes predictions. A material database of PHT piping materials is also being generated for use in LBB analysis.

Chattopadhyay, J.; Dutta, B.K.; Kushwaha, H.S. [Bhabha Atomic Research Centre, Bombay (India)] [and others

1997-04-01T23:59:59.000Z

470

EVIDENCE FOR ELEVATED X-RAY EMISSION IN LOCAL LYMAN BREAK GALAXY ANALOGS  

SciTech Connect (OSTI)

Our knowledge of how X-ray emission scales with star formation at the earliest times in the universe relies on studies of very distant Lyman break galaxies (LBGs). In this paper, we study the relationship between the 2-10 keV X-ray luminosity (L{sub X}), assumed to originate from X-ray binaries (XRBs), and star formation rate (SFR) in ultraviolet (UV) selected z < 0.1 Lyman break analogs (LBAs). We present Chandra observations for four new Galaxy Evolution Explorer selected LBAs. Including previously studied LBAs, Haro 11 and VV 114, we find that LBAs demonstrate L{sub X}/SFR ratios that are elevated by {approx}1.5{sigma} compared to local galaxies, similar to the ratios found for stacked LBGs in the early universe (z > 2). Unlike some of the composite LBAs studied previously, we show that these LBAs are unlikely to harbor active galactic nuclei, based on their optical and X-ray spectra and the spatial distribution of the X-rays in three spatially extended cases. Instead, we expect that high-mass X-ray binaries (HMXBs) dominate the X-ray emission in these galaxies, based on their high specific SFRs (sSFRs {identical_to} SFR/M{sub *} {>=} 10{sup -9} yr{sup -1}), which suggest the prevalence of young stellar populations. Since both UV-selected populations (LBGs and LBAs) have lower dust attenuations and metallicities compared to similar samples of more typical local galaxies, we investigate the effects of dust extinction and metallicity on the L{sub X}/SFR for the broader population of galaxies with high sSFRs (>10{sup -10} yr{sup -1}). The estimated dust extinctions (corresponding to column densities of N{sub H} < 10{sup 22} cm{sup -2}) are expected to have insignificant effects on observed L{sub X}/SFR ratio for the majority of galaxy samples. We find that the observed relationship between L{sub X}/SFR and metallicity appears consistent with theoretical expectations from XRB population synthesis models. Therefore, we conclude that lower metallicities, related to more luminous HMXBs such as ultraluminous X-ray sources, drive the elevated L{sub X}/SFR observed in our sample of z < 0.1 LBAs. The relatively metal-poor, active mode of star formation in LBAs and distant z > 2 LBGs may yield higher total HMXB luminosity than found in typical galaxies in the local universe.

Basu-Zych, Antara R.; Lehmer, Bret D.; Hornschemeier, Ann E.; Ptak, Andrew F. [NASA Goddard Space Flight Center, Code 662, Greenbelt, MD 20771 (United States); Goncalves, Thiago S. [Observatorio do Valongo, Universidade Federal do Rio de Janeiro, Ladeira Pedro Antonio 43, Saude, Rio de Janeiro-RJ, CEP 22240-060 (Brazil); Fragos, Tassos [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Heckman, Timothy M. [Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Overzier, Roderik A. [Department of Astronomy, University of Texas at Austin, 1 University Station C1400, Austin, TX 78712 (United States); Schiminovich, David, E-mail: antara.r.basu-zych@nasa.gov [Department of Astronomy, Columbia University, 550 West 120th Street, New York, NY 10027 (United States)

2013-09-10T23:59:59.000Z

471

Ergodicity breaking and wave-function statistics in disordered interacting systems  

SciTech Connect (OSTI)

We present the study of the structure of many-body eigenfunctions in a one-dimensional disordered spin chain. We discuss the choice of an appropriate basis in the Hilbert space, where the problem can be seen as an Anderson model defined on a high-dimensional non-trivial graph, determined by the many-body Hamiltonian. The comparison with the usual behavior of wave-functions in finite dimensional Anderson localization allows us to put in light the main differences of the many-body case. At high disorder, the typical eigenfunctions do not seem to localize though they occupy a infinitesimal portion of the Hilbert space in the thermodynamic limit. We perform a detailed analysis of the distribution of the wave-function coefficients and their peculiar scaling in the small and large disorder phase. We propose a criterion to identify the position of the transition by looking at the long tails of these distributions. The results coming from exact diagonalization show signs of breaking of ergodicity when the disorder reaches a critical value that agrees with the estimation of the many-body localization transition in the same model.

De Luca, Andrea [Laboratoire de Physique Théorique de l'ENS and Institut de Physique Theorique Philippe Meyer (France)

2014-08-20T23:59:59.000Z

472

Analysis of a Main Steam Line Break in Asco Nuclear Power Plant  

SciTech Connect (OSTI)

A comprehensive analysis of a double-ended main steam line break (MSLB) accident assumed to occur in the Asco nuclear power plant was carried out using the RELAP/PARCS coupled code. The general results of the benchmark provide a certain qualification of tools and methodologies used. Applying such methodologies to other plant models can be useful to extend conclusions and to identify areas where further analysis is needed. The calculations showed the capability of the control rod to recover the accident. However, one stuck control rod caused some recriticality or return to power (RTP), whose magnitude is heavily affected by the initial and boundary conditions. This paper identifies similarities and discrepancies between the benchmark calculation on the TMI-1 model and the Westinghouse three-loop calculation on the Asco model. The use of an integral plant model was helpful in showing the importance on the RTP of different plant systems that are modeled in detail. The high-pressure injection system and feedwater lines as well as the broken steam line model are the most significant.

Cuadra, Arantxa; Gago, Jose Luis; Reventos, Francesc

2001-06-17T23:59:59.000Z

473

Shifted focus point of the Higgs mass parameter from the minimal mixed mediation of SUSY breaking  

E-Print Network [OSTI]

We employ both the minimal gravity- and the minimal gauge mediations of supersymmetry breaking at the grand unified theory scale (GUT) in a single supergravity framework. In such a "minimal mixed mediation model," a "focus point" of the Higgs mass parameter, m_{h_u}^2 emerges at 3-4 TeV energy scale, which is exactly the stop mass scale needed for explaining the 126 GeV Higgs boson mass without the "A-term" at the three loop level. As a result, m_{h_u}^2 can be quite insensitive to various trial stop masses at low energy, reducing the fine-tuning measures to be much smaller than 100 even for 3-4 TeV low energy stop mass and -0.5 < A_t / m_0 < 0 at the GUT scale. In this model the gluino mass is predicted to be about 2.3 TeV, which could readily be tested at LHC run 2.

Kyae, Bumseok

2015-01-01T23:59:59.000Z

474

A dimension-breaking phenomenon for water waves with weak surface tension  

E-Print Network [OSTI]

It is well known that the water-wave problem with weak surface tension has small-amplitude line solitary-wave solutions which to leading order are described by the nonlinear Schr\\"odinger equation. The present paper contains an existence theory for three-dimensional periodically modulated solitary-wave solutions which have a solitary-wave profile in the direction of propagation and are periodic in the transverse direction; they emanate from the line solitary waves in a dimension-breaking bifurcation. In addition, it is shown that the line solitary waves are linearly unstable to long-wavelength transverse perturbations. The key to these results is a formulation of the water wave problem as an evolutionary system in which the transverse horizontal variable plays the role of time, a careful study of the purely imaginary spectrum of the operator obtained by linearising the evolutionary system at a line solitary wave, and an application of an infinite-dimensional version of the classical Lyapunov centre theorem.

Mark D. Groves; Shu-Ming Sun; Erik Wahlén

2014-11-10T23:59:59.000Z

475

Confinement, quark mass functions, and spontaneous chiral symmetry breaking in Minkowski space  

SciTech Connect (OSTI)

We formulate the covariant equations for quark-antiquark bound states in Minkowski space in the framework of the Covariant Spectator Theory. The quark propagators are dressed with the same kernel that describes the interaction between different quarks. We show that these equations are charge conjugation invariant, and that in the chiral limit of vanishing bare quark mass, a massless pseudoscalar bound state is produced in a Nambu--Jona-Lasinio (NJL) mechanism, which is associated with the Goldstone boson of spontaneous chiral symmetry breaking. In this introductory paper we test the formalism by using a simplified kernel consisting of a momentum-space $\\delta$-function with a vector Lorentz structure, to which one adds a mixed scalar and vector confining interaction. The scalar part of the confining interaction is not chirally invariant by itself, but decouples from the equations in the chiral limit and therefore allows the NJL mechanism to work. With this model we calculate the quark mass function, and we compare our Minkowski-space results to LQCD data obtained in Euclidean space. In a companion paper we apply this formalism to a calculation of the pion form factor.

Biernat, Elmar P. [CFTP, Institute Superior Tecnico, Lisboa (Portugal); Gross, Franz L. [JLAB, Newport News, VA (United States); Pena, Teresa [CFTP, Institute Superior Tecnico, Lisboa (Portugal); Stadler, Alfred [University of Evora, Lisboa (Portugal)

2014-01-01T23:59:59.000Z

476

Breaking the EOS-Gravity Degeneracy with Masses and Pulsating Frequencies of Neutron Stars  

E-Print Network [OSTI]

A thorough understanding of many astrophysical phenomena associated with compact objects requires reliable knowledge about both the equation of state (EOS)of super-dense nuclear matter and the theory of strong-field gravity simultaneously because of the EOS-gravity degeneracy. Currently, variations of the neutron star (NS) mass-radius correlation from using alternative gravity theories are much larger than those from changing the NS matter EOS within known constraints. At least two independent observables are required to break the EOS-gravity degeneracy. Using model EOSs for hybrid stars and a Yukawa-type non-Newtonian gravity, we investigate both the mass-radius correlation and pulsating frequencies of NSs. While the maximum mass of NSs increases, the frequencies of the $f$, $p_1$, $p_2$, and $w_I$ pulsating modes are found to decrease with the increasing strength of the Yukawa-type non-Newtonian gravity, providing a useful reference for future determination simultaneously of both the strong-field gravity and the supranuclear EOS by combining data of x-ray and gravitational wave emissions of neutron stars.

Weikang Lin; Bao-An Li; Lie-Wen Chen; De-Hua Wen; Jun Xu

2014-03-21T23:59:59.000Z

477

Spontaneous symmetry breaking in 2D: Kibble-Zurek mechanism in temperature quenched colloidal monolayers  

E-Print Network [OSTI]

The Kibble-Zurek mechanism describes the formation of topological defects during spontaneous symmetry breaking for quite different systems. Shortly after the big bang, the isotropy of the Higgs-field is broken during the expansion and cooling of the universe. Kibble proposed the formation of monopoles, strings, and membranes in the Higgs field since the phase of the symmetry broken field can not switch globally to gain the same value everywhere in space. Zurek pointed out that the same mechanism is relevant for second order phase transitions in condensed matter systems. Every finite cooling rate induces the system to fall out of equilibrium which is due to the critical slowing down of order parameter fluctuations: the correlation time diverges and the symmetry of the system can not change globally but incorporates defects between different domains. Depending on the cooling rate the heterogeneous order parameter pattern are a fingerprint of critical fluctuations. In the present manuscript we show that a monolayer of superparamagnetic colloidal particles is ideally suited to investigate such phenomena. In thermal equilibrium the system undergos continuous phase transitions according KTHNY-theory. If cooled rapidly across the melting temperature the final state is a polycrystal. We show, that the observations can not be explained with nucleation of a supercooled fluid but is compatible with the Kibble-Zurek mechanism.

Patrick Dillmann; Georg Maret; Peter Keim

2014-09-16T23:59:59.000Z

478

Proceedings of the seminar on leak before break in reactor piping and vessels  

SciTech Connect (OSTI)

The objective of the seminar was to present the current state of the art in Leak-Before-Break (LBB) methodology development, validation, and application in an international forum. With particular emphasis on industrial applications and regulatory policies, the seminar provided an opportunity to compare approaches, experiences, and codifications developed by different countries. The seminar was organized into four topic areas: status of LBB applications; technical issues in LBB methodology; complementary requirements (leak detection and inspection); LBB assessment and margins. As a result of this seminar, an improved understanding of LBB gained through sharing of different viewpoints from different countries, permits consideration of: simplified pipe support design and possible elimination of loss-of-coolant-accident (LOCA) mechanical consequences for specific cases; defense-in-depth type of applications without support modifications; support of safety cases for plants designed without the LOCA hypothesis. In support of these activities, better estimates of the limits to the LBB approach should follow, as well as an improvement in codifying methodologies. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

Faidy, C. [ed.] [Electricite de France, Villeurbanne (France); Gilles, P. [ed.] [Framatome, Paris (France)

1997-04-01T23:59:59.000Z

479

Leak before break behaviour of austenitic and ferritic pipes containing circumferential defects  

SciTech Connect (OSTI)

Several research projects carried out at MPA Stuttgart to investigate the Leak-before-Break (LBB) behavior of safety relevant pressure bearing components are summarized. Results presented relate to pipes containing circumferential defects subjected to internal pressure and external bending loading. An overview of the experimentally determined results for ferritic components is presented. For components containing postulated or actual defects, the dependence of the critical loading limit on the defect size is shown in the form of LBB curves. These are determined experimentally and/or by calculation for through-wall slits, and represent the boundary curve between leakage and massive fracture. For surface defects and a given bending moment and internal pressure, no fracture will occur if the length at leakage remains smaller than the critical defect length given by the LBB curve for through-wall defects. The predictive capability of engineering calculational methods are presented by way of example. The investigation programs currently underway, testing techniques, and initial results are outlined.

Stadtmueller, W.; Sturm, D.

1997-04-01T23:59:59.000Z

480

Spontaneous breaking of conformal invariance, solitons, and gravitational waves in theories of conformally invariant gravitation  

SciTech Connect (OSTI)

We study conformal gravity as an alternative theory of gravitation. For conformal gravity to be phenomenologically viable requires that the conformal symmetry is not manifest at the energy scales of the other known physical forces. Hence we are required to find a mechanism for the spontaneous breaking of conformal invariance. In this paper we study the possibility that conformal invariance is spontaneously broken due to interactions with conformally coupled matter fields. The vacuum of the theory admits conformally noninvariant solutions corresponding to maximally symmetric space-times and variants thereof. These are either de Sitter space-time or anti-de Sitter space-time in the full four space-time dimensions and we find new solutions corresponding to maximal symmetry restricted to a lower dimensional subspace. We also consider normalizable, linearized gravitational perturbations around the anti-de Sitter background. We show to second order, that these gravitational fluctuations carry zero energy momentum. Finally we also show the possibility of domain wall solitons interpolating between the ground states of spontaneously broken conformal symmetry that we have found. These solitons necessarily require the vanishing of the scalar field. This offers a way of eschewing the recent suggestion and its consequences [E. Flanagan, Phys. Rev. D 74, 023002 (2006).] that the conformal symmetry could be quarantined to a sterile sector of the theory by choosing an appropriate field redefinition.

Bouchami, Jihene [Groupe de physique des particules, Departement de physique, Universite de Montreal, Case Postale 6128, succursale Centre-ville, Montreal, Quebec, H3C 3J7 (Canada); Paranjape, M. B. [Groupe de physique des particules, Departement de physique, Universite de Montreal, Case Postale 6128, succursale Centre-ville, Montreal, Quebec, H3C 3J7 (Canada); Center for Quantum Spacetime, Department of Physics, Sogang University, Shinsu-dong 1, Mapo-gu, Seoul, 121-742 (Korea, Republic of)

2008-08-15T23:59:59.000Z

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481

Spontaneous R-Parity Breaking, Stop LSP Decays and the Neutrino Mass Hierarchy  

E-Print Network [OSTI]

The MSSM with right-handed neutrino supermultiplets, gauged B-L symmetry and a non-vanishing sneutrino expectation value is the minimal theory that spontaneously breaks R-parity and is consistent with the bounds on proton stability and lepton number violation. This minimal B-L MSSM can have a colored/charged LSP, of which a stop LSP is the most amenable to observation at the LHC. We study the R-parity violating decays of a stop LSP into a bottom quark and charged leptons--the dominant modes for a generic "admixture" stop. A numerical analysis of the relative branching ratios of these decay channels is given using a wide scan over the parameter space. The fact that R-parity is violated in this theory by a vacuum expectation value of a sneutrino links these branching ratios directly to the neutrino mass hierarchy. It is shown how a discovery of bottom-charged lepton events at the LHC can potentially determine whether the neutrino masses are in a normal or inverted hierarchy, as well as determining the theta_23 neutrino mixing angle. Finally, present LHC bounds on these leptoquark signatures are used to put lower bounds on the stop mass.

Zachary Marshall; Burt A. Ovrut; Austin Purves; Sogee Spinner

2014-06-03T23:59:59.000Z

482

Improved calculation of the isospin-symmetry-breaking corrections to superallowed Fermi beta decay  

E-Print Network [OSTI]

We report new shell-model calculations of the isospin-symmetry-breaking correction delta(C) to superallowed 0(+)-> 0(+) nuclear beta decay. The most important improvement is the inclusion of core orbitals, which are demonstrated to have a...this leads to small changes in delta(NS) as well. We also examine the new radiative-correction calculation by Marciano and Sirlin and, by a simple reorganization, show that it is possible to preserve the conventional separation into a nucleus-independent "inner" radiative term, Delta(V)(R), and a nucleus-dependent "outer" term, delta(')(R). We tabulate the new values for delta(C),delta(NS), and delta(')(R) for 20 superallowed transitions, including the 13 currently well-studied cases. With these new correction terms, the corrected Ft values for the 13 cases are statistically consistent with one another, and the anomalousness of the (46)V result disappears. These new calculations lead to a lower average (Ft) over bar value and a higher value for V(ud). The sum of squares of the top-row elements of the Cabibbo-Kobayashi-Maskawa matrix now agrees exactly with unitarity....

Towner, I. S.; Hardy, John C.

2008-01-01T23:59:59.000Z

483

Environmental Assessment and Finding of No Significant Impact: Pond B Dam Repair Project at the Savannah River Site  

SciTech Connect (OSTI)

The Department of Energy (DOE) has prepared an environmental assessment (EA) (DOE/EA-1285) for the proposed repair of the Pond B dam at the Savannah River Site (SRS), located near Aiken, South Carolina. Based on the analyses in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an environmental impact statement (EIS) is not required, and DOE is issuing this Finding of No Significant Impact (FONSI) and Floodplain Statement of Findings.

N /A

1999-09-27T23:59:59.000Z

484

The effect of symmetry breaking on the dynamics near a structurally stable heteroclinic cycle between equilibria and a periodic orbit  

E-Print Network [OSTI]

The effect of small forced symmetry breaking on the dynamics near a structurally stable heteroclinic cycle connecting two equilibria and a periodic orbit is investigated. This type of system is known to exhibit complicated, possibly chaotic dynamics including irregular switching of sign of various phase space variables, but details of the mechanisms underlying the complicated dynamics have not previously been investigated. We identify global bifurcations that induce the onset of chaotic dynamics and switching near a heteroclinic cycle of this type, and by construction and analysis of approximate return maps, locate the global bifurcations in parameter space. We find there is a threshold in the size of certain symmetry-breaking terms below which there can be no persistent switching. Our results are illustrated by a numerical example.

Vivien Kirk; Alastair M. Rucklidge

2008-05-07T23:59:59.000Z

485

IJOPE Paper No JC-343AB-final 9/26/04 Biausser Page number 1 Numerical Analysis of the Internal Kinematics and Dynamics of 3D Breaking Waves on Slopes  

E-Print Network [OSTI]

Kinematics and Dynamics of 3D Breaking Waves on Slopes Benjamin Biausser1 , Stéphan T. Grilli2 , Philippe and internal kinematics (velocity, vorticity, pressure) are presented. KEY WORDS: breaking ocean waves years, our understanding of wave breaking dynamics and kinematics is still quite incomplete. Due

Grilli, Stéphan T.

486

The {open_quotes}leak-before-break{close_quotes} applicability in decision support system {open_quotes}strength{close_quotes}  

SciTech Connect (OSTI)

A software decision support system, STRENGTH, for application of leak before break analysis, is described. The background methodology and sample application are outlined. The program allows multioptional computation of loading parameters for different types of defects, and variable properties for metals and welded joints. Structural strength is assessed, and service life predictions are made. The program is used to analyze specific defects identified by nondestructive testing.

Torop, V.M.; Orynyak, I.V. [Institute for Problems of Strength, Kiev (Ukraine); Kutovoy, O.L. [Institute of Structure Integrity, Kiev (Ukraine)

1997-04-01T23:59:59.000Z

487

Assessment of RELAP/MOD3 using BETHSY 6.2TC 6-inch cold leg side break comparative test  

SciTech Connect (OSTI)

This report presents the results of the RELAP5/MOD3 Version 7j assessment on BETHSY 6.2TC. BETHSY 6.2TC test corresponding to a six inch cold leg break LOCA of the Pressurizer Water Reactor(PWR). The primary objective of the test was to provide reference data of two facilities of different scales (BETHSY and LSTF facility). On the other hand, the present calculation aims at analysis of RELAP5/N4OD3 capability on the small break LOCA simulation, The results of calculation have shown that the RELAP5/MOD3 reasonably predicts occurrences as well as trends of the major phenomena such as primary pressure, timing of loop seal clearing, liquid hold up, etc. However, some disagreements also have been found in the predictions of loop seal clearing, collapsed core water level after loop seal clearing, and accumulator injection behaviors. For better understanding of discrepancies in same predictions, several sensitivity calculations have been performed as well. These include the changes of two-phase discharge coefficient at the break junction and some corrections of the interphase drag term. As result, change of a single parameter has not improved the overall predictions and it has been found that the interphase drag model has still large uncertainties.

Chung, Young-Jong; Jeong, Jae-Jun; Chang, Won-Pyo; Kim, Dong-Su [Korea Atomic Energy Research Institute, Yusung, Taejon (Korea, Republic of)] [and others

1996-10-01T23:59:59.000Z

488

Probabilistic evaluation of main coolant pipe break indirectly induced by earthquakes: Savannah River Project L and P Reactors  

SciTech Connect (OSTI)

A probabilistic evaluation of seismically-induced indirect pipe break for the Savannah River Project (SRP) L- and P-Reactor main coolant (process water) piping has been conducted. Seismically-induced indirect pipe break can result primarily from: (1) failure of the anchorage of one or more of the components to which the pipe is anchored; or (2) failure of the pipe due to collapse of the structure. The potential for both types of seismically-induced indirect failures was identified during a seismic walkdown of the main coolant piping. This work involved: (1) identifying components or structures whose failure could result in pipe failure; (2) developing seismic capacities or fragilities of these components; (3) combining component fragilities to develop plant damage state fragilities; and (4) convolving the plant seismic fragilities with a probabilistic seismic hazard estimate for the site in order to obtain estimates of seismic risk in terms of annual probability of seismic-induced indirect pipe break. 6 refs., 5 figs., 2 tabs.

Short, S.A.; Wesley, D.A.; Awadalla, N.G.; Kennedy, R.P. (Impell Corp., Mission Viejo, CA (USA); Westinghouse Savannah River Co., Aiken, SC (USA); Structural Mechanics Consulting, Inc., Yorba Linda, CA (USA))

1989-01-01T23:59:59.000Z

489

Additional requirements for leak-before-break application to primary coolant piping in Belgium  

SciTech Connect (OSTI)

Leak-Before-Break (LBB) technology has not been applied in the first design of the seven Pressurized Water Reactors the Belgian utility is currently operating. The design basis of these plants required to consider the dynamic effects associated with the ruptures to be postulated in the high energy piping. The application of the LBB technology to the existing plants has been recently approved by the Belgian Safety Authorities but with a limitation to the primary coolant loop. LBB analysis has been initiated for the Doel 3 and Tihange 2 plants to allow the withdrawal of some of the reactor coolant pump snubbers at both plants and not reinstall some of the restraints after steam generator replacement at Doel 3. LBB analysis was also found beneficial to demonstrate the acceptability of the primary components and piping to the new conditions resulting from power uprating and stretch-out operation. LBB analysis has been subsequently performed on the primary coolant loop of the Tihange I plant and is currently being performed for the Doel 4 plant. Application of the LBB to the primary coolant loop is based in Belgium on the U.S. Nuclear Regulatory Commission requirements. However the Belgian Safety Authorities required some additional analyses and put some restrictions on the benefits of the LBB analysis to maintain the global safety of the plant at a sufficient level. This paper develops the main steps of the safety evaluation performed by the Belgian Safety Authorities for accepting the application of the LBB technology to existing plants and summarizes the requirements asked for in addition to the U.S. Nuclear Regulatory Commission rules.

Roussel, G. [AIB Vincotte Nuclear, Brussels (Belgium)

1997-04-01T23:59:59.000Z

490

Short-range Ising spin glasses: the metastate interpretation of replica symmetry breaking  

E-Print Network [OSTI]

Parisi's formal replica-symmetry--breaking (RSB) scheme for mean-field spin glasses has long been interpreted in terms of many pure states organized ultrametrically. However, the early version of this interpretation, as applied to the short-range Edwards-Anderson model, runs into problems because as shown by Newman and Stein (NS) it does not allow for chaotic size dependence, and predicts non-self-averaging that cannot occur. NS proposed the concept of the metastate (a probability distribution over infinite-size Gibbs states in a given sample that captures the effects of chaotic size dependence) and a non-standard interpretation of the RSB results in which the metastate is non-trivial and is responsible for what was called non-self-averaging. Here we use the effective field theory of RSB, in conjunction with the rigorous definitions of pure states and the metastate in infinite-size systems, to show that the non-standard picture follows directly from the RSB mean-field theory. In addition, the metastate-averaged state possesses power-law correlations throughout the low temperature phase; the corresponding exponent $\\zeta$ takes the value $4$ according to the field theory in high dimensions $d$, and describes the effective fractal dimension of clusters of spins. Further, the logarithm of the number of pure states in the decomposition of the metastate-averaged state that can be distinguished if only correlations in a window of size $W$ can be observed is of order $W^{d-\\zeta}$. These results extend the non-standard picture quantitatively; we show that arguments against this scenario are inconclusive.

N. Read

2014-09-19T23:59:59.000Z

491

Genome-Wide Identification and 3D Modeling of Proteins involved in DNA Damage Recognition and Repair (Final Report)  

SciTech Connect (OSTI)

OAK-B135 DNA Damage Recognition and Repair (DDR and R) proteins play a critical role in cellular responses to low-dose radiation and are associated with cancer. the authors have performed a systematic, genome-wide computational analysis of genomic data for human genes involved in the DDR and R process. The significant achievements of this project include: (1) Construction of the computational pipeline for searching DDR and R genes, building and validation of 3D models of proteins involved in DDR and R; (2) Functional and structural annotation of the 3D models and generation of comprehensive lists of suggested knock-out mutations; (3) Important improvement of macromolecular docking technology and its application to predict the DNA-Protein complex conformation; (4) Development of a new algorithm for improved analysis of high-density oligonucleotide arrays for gene expression profiling; (5) Construction and maintenance of the DNA Damage Recognition and Repair Database; and (6) Producing 14 research papers (10 published and 4 in preparation).

Ruben A. Abagyan, PhD

2004-04-15T23:59:59.000Z

492

Breaking ECC2K-130 Daniel V. Bailey1,10, Lejla Batina2, Daniel J. Bernstein3, Peter Birkner4, Joppe W. Bos5,  

E-Print Network [OSTI]

Breaking ECC2K-130 Daniel V. Bailey1,10, Lejla Batina2, Daniel J. Bernstein3, Peter Birkner4, Joppe, CH-1015 Lausanne, Switzerland {joppe.bos, thorsten.kleinjung}@epfl.ch 6 Academia Sinica, Taiwan {kc

Bernstein, Daniel

493

Commercial Aircraft Corporation of China (Comac) attempts to break the Airbus-Boeing duopoly, will it succeed? : an industry analysis framework applied  

E-Print Network [OSTI]

Using an industry analysis framework, this thesis analyzes whether the recently established Commercial Aircraft Corporation of China (Comac) is likely to break the Boeing-Airbus duopoly in the industry of large commercial ...

Fuentes, Jose L., S.M. Massachusetts Institute of Technology

2011-01-01T23:59:59.000Z

494

Proceedings of the 1992 workshops on high-energy physics with colliding beams. Volume 3, Electroweak symmetry breaking at colliding-beam facilities  

SciTech Connect (OSTI)

This report contains viewgraphs on the following topics: Introduction to Electroweak Symmetry Breaking: Intermediate-Mass Higgs Bosons; Extended Higgs Sectors and Novel Searches; and Heavy Higgs Bosons and Strong WW Scattering.

Rogers, J. [ed.

1992-12-31T23:59:59.000Z

495

Function of the ATR N-terminal domain revealed by an ATM/ATR chimera  

SciTech Connect (OSTI)

The ATM and ATR kinases function at the apex of checkpoint signaling pathways. These kinases share significant sequence similarity, phosphorylate many of the same substrates, and have overlapping roles in initiating cell cycle checkpoints. However, they sense DNA damage through distinct mechanisms. ATR primarily senses single stranded DNA (ssDNA) through its interaction with ATRIP, and ATM senses double strand breaks through its interaction with Nbs1. We determined that the N-terminus of ATR contains a domain that binds ATRIP. Attaching this domain to ATM allowed the fusion protein (ATM*) to bind ATRIP and associate with RPA-coated ssDNA. ATM* also gained the ability to localize efficiently to stalled replication forks as well as double strand breaks. Despite having normal kinase activity when tested in vitro and being phosphorylated on S1981 in vivo, ATM* is defective in checkpoint signaling and does not complement cellular deficiencies in either ATM or ATR. These data indicate that the N-terminus of ATR is sufficient to bind ATRIP and to promote localization to sites of replication stress.

Chen Xinping [Department of Biochemistry, Vanderbilt University, 613 Light Hall, 23rd, Pierce Avenue, Nashville, TN 37232 (United States); Zhao Runxiang [Department of Biochemistry, Vanderbilt University, 613 Light Hall, 23rd, Pierce Avenue, Nashville, TN 37232 (United States); Glick, Gloria G. [Department of Biochemistry, Vanderbilt University, 613 Light Hall, 23rd, Pierce Avenue, Nashville, TN 37232 (United States); Cortez, David [Department of Biochemistry, Vanderbilt University, 613 Light Hall, 23rd, Pierce Avenue, Nashville, TN 37232 (United States)]. E-mail: david.cortez@vanderbilt.edu

2007-05-01T23:59:59.000Z

496

Meter Damage: Many customers have questions about who is responsible for repair to the electrical service at their homes. These pages may help to answer  

E-Print Network [OSTI]

Meter Damage: Many customers have questions about who is responsible for repair. weather head stack meter base connectors house knob weather head connectors mast clamp stack meter base meter meter #12; Let's start with definitions: Meter base: This is the metal box mounted

Rose, Annkatrin

497

Architectural Repair of Open Source Software John B. Tran, Michael W. Godfrey, Eric H.S. Lee, and Richard C. Holt  

E-Print Network [OSTI]

large open source systems (the Linux operating system kernel and the VIM text editor) to aid program: the Linux operating system kernel [3, 1] and the VIM text editor [5]. We analyzed their architectures experiences with the repair of the Linux and VIM ar- chitectures. A description of related work is presented

Godfrey, Michael W.

498

SMITH, GLEN. Bond Characteristics and Qualifications of Adhesives for Marine Applications and Steel Pipe Repair. (Under the direction of Dr. Sami Rizkalla.)  

E-Print Network [OSTI]

designs using new materials. Adhesives that bond metals, plastics, FRP and other materials have been used for marine application and repair of steel pipeline. #12;BOND CHARACTERISTICS AND QUALIFICATIONS OF ADHESIVES of Science Department of Civil, Construction, and Environmental Engineering Raleigh 2005 APPROVED BY

499

Assembly and Repair of Membrane-Bound Electron Transport Complexes similar to NifS than is Slr0387, but shows strong  

E-Print Network [OSTI]

Assembly and Repair of Membrane-Bound Electron Transport Complexes similar to NifS than is Slr0387 in the maturation of FeS proteins. We found that under some conditions the Synechocystis NifU-like protein can oxidation of the cysteine side chains at NifU. The same reaction might have occurred in lysed chloroplasts

500

Exemption from Application of the Service Contract Act -Certification UT-B Contracts Div Maintenance, Calibration, or Repair of Certain Equipment  

E-Print Network [OSTI]

Exemption from Application of the Service Contract Act - Certification UT-B Contracts Div-sca-equip-certification-ext-venx-mar09.doc EXEMPTION FROM APPLICATION OF THE SERVICE CONTRACT ACT ­ MAINTENANCE, CALIBRATION, OR REPAIR to the conditions in paragraph (a) of this provision, and the Company determines that the Service Contract Act ­ (1

Pennycook, Steve