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1

The Role of DNA double-strand break repair in cellular response to low  

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DNA double-strand break repair in cellular response to low DNA double-strand break repair in cellular response to low dose radiation exposure. David J. Chen Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas TX 75390 It has been assumed that molecular pathways that involved in the biological response for low dose of radiation should be similar to those for high dose radiation in general. The low dose-rate effect and DNA double-strand break repair are inextricably linked in mammalian cells. It has been reported that mammalian mutant cells deficient in nonhomologous end join (NHEJ) pathway have little or no cellular recovery when expose to low-dose-rate radiation. Recently, it has also been reported that cells deficient in

2

ASSESSMENT OF INDIVIDUAL VARIATION IN DNA DOUBLE-STRAND BREAK REPAIR CAPACITY IN HUMAN DIPLOID FIBROBLASTS  

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ASSESSMENT OF INDIVIDUAL VARIATION IN DNA DOUBLE-STRAND ASSESSMENT OF INDIVIDUAL VARIATION IN DNA DOUBLE-STRAND BREAK REPAIR CAPACITY IN HUMAN DIPLOID FIBROBLASTS Paul F. Wilson, John M. Hinz, Peter B. Nham, Salustra S. Urbin, Cynthia B. Thomas, Irene M. Jones, and Larry H. Thompson Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA The induction of bi-stranded clustered DNA damage (BCD), which includes direct DNA double-strand breaks (DSBs), is a hallmark of ionizing radiation (IR) exposure. Incorrectly repaired DSBs can cause chromosomal rearrangements and an increased risk of genomic instability and cancer. Because there is polymorphic variation in DNA repair genes and much of this variation is predicted to have a functional impact, healthy people likely vary in their capacity to repair DSBs and other BCD. This project

3

A Key Step in Repairing DNA Double-Strand Breaks | Advanced Photon Source  

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X-ray Rainbow X-ray Rainbow An Insulating Breakthrough Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Step in Repairing DNA Double-Strand Breaks JANUARY 10, 2007 Bookmark and Share The atomic structure of the protein 53BP1 identified by Mayo researchers. (Courtesy: Mayo Clinic) A team of Mayo Clinic researchers has uncovered a key step in the molecular pathway of repairing DNA double-strand breaks. The studies were carried out using the 19-ID beamline (SBC-CAT) at the Advanced Photon Source (APS, Argonne) and the X12-C beamline at the National Synchrotron Light Source (NSLS, Brookhaven National Laboratory). Both the APS and the NSLS are funded by the U.S. Department of Energy's Office of Basic Energy

4

Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells  

Science Conference Proceedings (OSTI)

Cytotoxicity and DNA double strand breaks (DSBs) were studied in HeLa cells treated with sulforaphane (SFN), a well-known chemo-preventive agent. Cell survival was impaired by SFN in a concentration and treatment time-dependent manner. Both constant field gel electrophoresis (CFGE) and {gamma}-H2AX assay unambiguously indicated formation of DSBs by SFN, reflecting the cell survival data. These DSBs were predominantly processed by homologous recombination repair (HRR), judging from the SFN concentration-dependent manner of Rad51 foci formation. On the other hand, the phosphorylation of DNA-PKcs, a key non-homologous end joining (NHEJ) protein, was not observed by SFN treatment, suggesting that NHEJ may not be involved in DSBs induced by this chemical. G2/M arrest by SFN, a typical response for cells exposed to ionizing radiation was also observed. Our new data indicate the clear induction of DSBs by SFN and a useful anti-tumor aspect of SFN through the induction of DNA DSBs.

Sekine-Suzuki, Emiko [Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Graduate School of Advanced Integration Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan); Yu, Dong [Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Kubota, Nobuo [Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, 4669-2 Ami, Ami-machi, Inashiki-gun, Ibaraki 300-0394 (Japan); Okayasu, Ryuichi [Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Anzai, Kazunori [Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Graduate School of Advanced Integration Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan)], E-mail: anzai@nirs.go.jp

2008-12-12T23:59:59.000Z

5

ZIP4H (TEX11) Deficiency in the Mouse Impairs Meiotic Double Strand Break Repair and the Regulation of Crossing Over  

E-Print Network (OSTI)

We have recently shown that hypomorphic Mre11 complex mouse mutants exhibit defects in the repair of meiotic double strand breaks (DSBs). This is associated with perturbation of synaptonemal complex morphogenesis, repair and regulation of crossover formation. To further assess the Mre11 complex’s role in meiotic progression, we identified testis-specific NBS1interacting proteins via two-hybrid screening in yeast. In this screen, Zip4h (Tex11), a male germ cell specific X-linked gene was isolated. Based on sequence and predicted structural similarity to the S. cerevisiae and A. thaliana Zip4 orthologs, ZIP4H appears to be the mammalian ortholog. In S. cerevisiae and A. thaliana, Zip4 is a meiosis-specific protein that regulates the level of meiotic crossovers, thus influencing homologous chromosome segregation in these organisms. As is true for hypomorphic Nbs1 (Nbs1 DB/DB) mice, Zip4h 2/Y mutant mice were fertile. Analysis of spermatocytes revealed a delay in meiotic double strand break repair and decreased crossover formation as inferred from DMC1 and MLH1 staining patterns, respectively. Achiasmate chromosomes at the first meiotic division were also observed in Zip4h 2/Y mutants, consistent with the observed reduction in MLH1 focus formation. These results indicate that meiotic functions of Zip4 family members are conserved and support the view that the Mre11 complex and ZIP4H interact functionally during the execution of the

Carrie A. Adelman; John H. J. Petrini

2008-01-01T23:59:59.000Z

6

Gene Expression Pathways Activated and Repair of DNA of Double Strand  

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Pathways Activated and Repair of DNA of Double Strand Pathways Activated and Repair of DNA of Double Strand Breaks (DSBs) Following Low Dose Ionizing Radiation in Human Bronchial Epithelial Cells (HBECs) With and Without Defined Premalignant Oncogenic Changes John Minna University of Texas Southwestern Medical Center at Dallas Abstract We want to determine the effect of low dose ionizing radiation on the molecular progression of lung epithelial cells towards lung cancer. Our endpoints are focused on specific molecular and cellular changes known to be associated with lung cancer development and quantitating those changes as a function of low dose ionizing radiation. We use immortalized human bronchial epithelial cells (HBECs) developed from >40 individuals (including those from current, former, and never smokers, males, females,

7

Quantitative, non-invasive imaging of radiation-induced DNA double strand breaks in vivo  

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Quantitative, non-invasive imaging of radiation-induced DNA double strand breaks in vivo Quantitative, non-invasive imaging of radiation-induced DNA double strand breaks in vivo Wenrong Li 1, , Fang Li 1 , Qian Huang 1 , Jingping Shen 1 , Frank Wolf 1 , Yujun He 1 , Xinjian Liu 1 , Y. Angela Hu 1 , Joel. S. Bedford 5 , and Chuan-Yuan Li 1,2,* Departments of 1 Radiation Oncology, 2 Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA; 3 Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA DNA double strand breaks are a major form of DNA damage and a key mechanism through which radiotherapy and some chemotherapeutic agents kill cancer cells. Despite its importance, measuring DNA double strand breaks is still a tedious task that is normally carried out by gel electrophoresis or immunofluorescence staining. Here we report a novel approach to image and

8

Accumulation of DNA Double-Strand Breaks in Normal Tissues After Fractionated Irradiation  

SciTech Connect

Purpose: There is increasing evidence that genetic factors regulating the recognition and/or repair of DNA double-strand breaks (DSBs) are responsible for differences in radiosensitivity among patients. Genetically defined DSB repair capacities are supposed to determine patients' individual susceptibility to develop adverse normal tissue reactions after radiotherapy. In a preclinical murine model, we analyzed the impact of different DSB repair capacities on the cumulative DNA damage in normal tissues during the course of fractionated irradiation. Material and Methods: Different strains of mice with defined genetic backgrounds (SCID{sup -/-} homozygous, ATM{sup -/-} homozygous, ATM{sup +/-}heterozygous, and ATM{sup +/+}wild-type mice) were subjected to single (2 Gy) or fractionated irradiation (5 x 2 Gy). By enumerating gammaH2AX foci, the formation and rejoining of DSBs were analyzed in organs representative of both early-responding (small intestine) and late-responding tissues (lung, kidney, and heart). Results: In repair-deficient SCID{sup -/-} and ATM{sup -/-}homozygous mice, large proportions of radiation-induced DSBs remained unrepaired after each fraction, leading to the pronounced accumulation of residual DNA damage after fractionated irradiation, similarly visible in early- and late-responding tissues. The slight DSB repair impairment of ATM{sup +/-}heterozygous mice was not detectable after single-dose irradiation but resulted in a significant increase in unrepaired DSBs during the fractionated irradiation scheme. Conclusions: Radiation-induced DSBs accumulate similarly in acute- and late-responding tissues during fractionated irradiation, whereas the whole extent of residual DNA damage depends decisively on the underlying genetically defined DSB repair capacity. Moreover, our data indicate that even minor impairments in DSB repair lead to exceeding DNA damage accumulation during fractionated irradiation and thus may have a significant impact on normal tissue responses in clinical radiotherapy.

Ruebe, Claudia E., E-mail: claudia.ruebe@uks.e [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany); Fricke, Andreas; Wendorf, Juliane; Stuetzel, Annika; Kuehne, Martin [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany); Ong, Mei Fang [Institute of Medical Biometrics, Epidemiology and Medical Informatics, Saarland University, Homburg/Saar (Germany); Lipp, Peter [Institute for Molecular Cell Biology, Saarland University, Homburg/Saar (Germany); Ruebe, Christian [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany)

2010-03-15T23:59:59.000Z

9

Single-nucleotide polymorphisms in base excision repair, nucleotide excision repair, and double strand break genes as markers for response to radiotherapy in patients with Stage I to II head-and-neck cancer  

SciTech Connect

Purpose: Polymorphisms in DNA repair genes can influence response to radiotherapy. We analyzed single-nucleotide polymorphisms (SNP) in nine DNA repair genes in 108 patients with head-and-neck cancer (HNSCC) who had received radiotherapy only. Methods and Materials: From May 1993 to December 2004, patients with Stage I and II histopathologically confirmed HNSCC underwent radiotherapy. DNA was obtained from paraffin-embedded tissue, and SNP analysis was performed using a real-time polymerase chain reaction allelic discrimination TaqMan assay with minor modifications. Results: Patients were 101 men (93.5%) and 7 (6.5%) women, with a median age of 64 years (range, 40 to 89 years). Of the patients, 76 (70.4%) patients were Stage I and 32 (29.6%) were Stage II. The XPF/ERCC1 SNP at codon 259 and XPG/ERCC5 at codon 46 emerged as significant predictors of progression (p 0.00005 and 0.049, respectively) and survival (p = 0.0089 and 0.0066, respectively). Similarly, when variant alleles of XPF/ERCC1, XPG/ERCC5 and XPA were examined in combination, a greater number of variant alleles was associated with shorter time to progression (p = 0.0003) and survival (p 0.0002). Conclusions: Genetic polymorphisms in XPF/ERCC1, XPG/ERCC5, and XPA may significantly influence response to radiotherapy; large studies are warranted to confirm their role in HNSCC.

Carles, Joan [Department of Medical Oncology, Hospital del Mar, University Autonoma of Barcelona, Barcelona (Spain)]. E-mail: jcarles@imas.imim.es; Monzo, Mariano [Department of Human Anatomy, Faculty of Medicine, University of Barcelona, Barcelona (Spain); Amat, Marta [Department of Otolaryngology, Hospital del Mar, University Autonoma of Barcelona, Barcelona (Spain); Jansa, Sonia [Department of Human Anatomy, Faculty of Medicine, University of Barcelona, Barcelona (Spain); Artells, Rosa [Department of Human Anatomy, Faculty of Medicine, University of Barcelona, Barcelona (Spain); Navarro, Alfons [Department of Human Anatomy, Faculty of Medicine, University of Barcelona, Barcelona (Spain); Foro, Palmira [Department of Radiation Oncology, Hospital del Mar, University Autonoma of Barcelona, Barcelona (Spain); Alameda, Francesc [Department of Pathology, Hospital del Mar, University Autonoma of Barcelona, Barcelona (Spain); Gayete, Angel [Department of Radiology, Hospital del Mar, University Autonoma of Barcelona, Barcelona (Spain); Gel, Bernat [Department of Human Anatomy, Faculty of Medicine, University of Barcelona, Barcelona (Spain); Miguel, Maribel [Department of Human Anatomy, Faculty of Medicine, University of Barcelona, Barcelona (Spain); Albanell, Joan [Department of Medical Oncology, Hospital del Mar, University Autonoma of Barcelona, Barcelona (Spain); Fabregat, Xavier [Department of Medical Oncology, Hospital del Mar, University Autonoma of Barcelona, Barcelona (Spain)

2006-11-15T23:59:59.000Z

10

Induction and Rejoining of DNA Double Strand Breaks Assessed by H2AX Phosphorylation in Melanoma Cells Irradiated with Proton and Lithium Beams  

SciTech Connect

Purpose: The aim of this study was to evaluate the induction and rejoining of DNA double strand breaks (DSBs) in melanoma cells exposed to low and high linear energy transfer (LET) radiation. Methods and Materials: DSBs and survival were determined as a function of dose in melanoma cells (B16-F0) irradiated with monoenergetic proton and lithium beams and with a gamma source. Survival curves were obtained by clonogenic assay and fitted to the linear-quadratic model. DSBs were evaluated by the detection of phosphorylated histone H2AX ({gamma}H2AX) foci at 30 min and 6 h post-irradiation. Results: Survival curves showed the increasing effectiveness of radiation as a function of LET. {gamma}H2AX labeling showed an increase in the number of foci vs. dose for all the radiations evaluated. A decrease in the number of foci was found at 6 h post-irradiation for low LET radiation, revealing the repair capacity of DSBs. An increase in the size of {gamma}H2AX foci in cells irradiated with lithium beams was found, as compared with gamma and proton irradiations, which could be attributed to the clusters of DSBs induced by high LET radiation. Foci size increased at 6 h post-irradiation for lithium and proton irradiations in relation with persistent DSBs, showing a correlation with surviving fraction. Conclusions: Our results showed the response of B16-F0 cells to charged particle beams evaluated by the detection of {gamma}H2AX foci. We conclude that {gamma}H2AX foci size is an accurate parameter to correlate the rejoining of DSBs induced by different LET radiations and radiosensitivity.

Ibanez, Irene L. [Comision Nacional de Energia Atomica, San Martin (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Bracalente, Candelaria [Comision Nacional de Energia Atomica, San Martin (Argentina); Molinari, Beatriz L. [Comision Nacional de Energia Atomica, San Martin (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Palmieri, Monica A. [Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (Argentina); Policastro, Lucia [Comision Nacional de Energia Atomica, San Martin (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Kreiner, Andres J. [Comision Nacional de Energia Atomica, San Martin (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin (Argentina); Burlon, Alejandro A. [Comision Nacional de Energia Atomica, San Martin (Argentina); Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin (Argentina); Valda, Alejandro [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin (Argentina); Navalesi, Daniela [Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (Argentina); Davidson, Jorge; Davidson, Miguel [Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Vazquez, Monica; Ozafran, Mabel [Comision Nacional de Energia Atomica, San Martin (Argentina); Duran, Hebe [Comision Nacional de Energia Atomica, San Martin (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (Argentina); Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin (Argentina)], E-mail: hduran@cnea.gov.ar

2009-07-15T23:59:59.000Z

11

Low Dose Radiation Research Program: Quantification of Repair...  

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Quantification of Repair of Low-Dose-Induced DNA Double-Strand Breaks in Diploid Human Cells David Schild Lawrence Berkeley National Laboratory Berkeley, California Why this...

12

DNA Double-Strand Break Analysis by {gamma}-H2AX Foci: A Useful Method for Determining the Overreactors to Radiation-Induced Acute Reactions Among Head-and-Neck Cancer Patients  

SciTech Connect

Purpose: Interindividual variability in normal tissue toxicity during radiation therapy is a limiting factor for successful treatment. Predicting the risk of developing acute reactions before initiation of radiation therapy may have the benefit of opting for altered radiation therapy regimens to achieve minimal adverse effects with improved tumor cure. Methods and Materials: DNA double-strand break (DSB) induction and its repair kinetics in lymphocytes of head-and-neck cancer patients undergoing chemoradiation therapy was analyzed by counting {gamma}-H2AX foci, neutral comet assay, and a modified version of neutral filter elution assay. Acute normal tissue reactions were assessed by Radiation Therapy Oncology Group criteria. Results: The correlation between residual DSBs and the severity of acute reactions demonstrated that residual {gamma}-H2AX foci in head-and-neck cancer patients increased with the severity of oral mucositis and skin reaction. Conclusions: Our results suggest that {gamma}-H2AX analysis may have predictive implications for identifying the overreactors to mucositis and skin reactions among head-and-neck cancer patients prior to initiation of radiation therapy.

Goutham, Hassan Venkatesh; Mumbrekar, Kamalesh Dattaram [Division of Radiobiology and Toxicology, Manipal Life Sciences Centre, Manipal University, Manipal, Karnataka (India)] [Division of Radiobiology and Toxicology, Manipal Life Sciences Centre, Manipal University, Manipal, Karnataka (India); Vadhiraja, Bejadi Manjunath [Manipal Hospital, Bangalore, Karnataka (India)] [Manipal Hospital, Bangalore, Karnataka (India); Fernandes, Donald Jerard; Sharan, Krishna [Department of Radiotherapy and Oncology, Shiridi Sai Baba Cancer Hospital and Research Centre, Kasturba Hospital, Manipal, Karnataka (India)] [Department of Radiotherapy and Oncology, Shiridi Sai Baba Cancer Hospital and Research Centre, Kasturba Hospital, Manipal, Karnataka (India); Kanive Parashiva, Guruprasad; Kapaettu, Satyamoorthy [Division of Biotechnology, Manipal Life Sciences Centre, Manipal University, Manipal, Karnataka (India)] [Division of Biotechnology, Manipal Life Sciences Centre, Manipal University, Manipal, Karnataka (India); Bola Sadashiva, Satish Rao, E-mail: satishraomlsc@gmail.com [Division of Radiobiology and Toxicology, Manipal Life Sciences Centre, Manipal University, Manipal, Karnataka (India)

2012-12-01T23:59:59.000Z

13

Microsoft PowerPoint - Powerpoint_WebRepair.ppt [Compatibility...  

NLE Websites -- All DOE Office Websites (Extended Search)

strand break repair is usually error free. g p y * Double strand breaks can be either error free or error t i i hi h t prone, containing a high error rate. Mechanisms of Repair...

14

Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions  

E-Print Network (OSTI)

tightly regulated for doxycycline-inducible shRNA expressioninduced by adding 1 µg/ml doxycycline to the growth mediumfor 16 h (without doxycycline) or 18 h (with doxycycline).

Zafar, Faria

2010-01-01T23:59:59.000Z

15

Suberoylanilide Hydroxyamic Acid Modification of Chromatin Architecture Affects DNA Break Formation and Repair  

Science Conference Proceedings (OSTI)

Purpose: Chromatin-modifying compounds that inhibit the activity of histone deacetylases have shown potency as radiosensitizers, but the action of these drugs at a molecular level is not clear. Here we investigated the effect of suberoylanilide hydroxyamic acid (SAHA) on DNA breaks and their repair and induction of rearrangements. Methods and Materials: The effect of SAHA on both clonogenic survival and repair was assessed using cell lines SCC-25, MCF7, and TK6. In order to study unique DNA double-strand breaks, anti-CD95 antibody was employed to introduce a DNA double-strand break at a known location within the 11q23 region. The effects of SAHA on DNA cleavage and rearrangements were analyzed by ligation-mediated PCR and inverse PCR, respectively. Results: SAHA acts as radiosensitizer at 1 {mu}M, with dose enhancement factors (DEFs) at 10% survival of: SCC-25 - 1.24 +- 0.05; MCF7 - 1.16 +- 0.09 and TK6 - 1.17 +- 0.05, and it reduced the capacity of SCC-25 cells to repair radiation induced lesions. Additionally, SAHA treatment diffused site-specific fragmentation over at least 1 kbp in TK6 cells. Chromosomal rearrangements produced in TK6 cells exposed to SAHA showed a reduction in microhomology at the breakpoint between 11q23 and partner chromosomes. Conclusions: SAHA shows efficacy as a radiosensitizer at clinically obtainable levels. In its presence, targeted DNA strand breaks occur over an expanded region, indicating increased chromatin access. The rejoining of such breaks is degraded by SAHA when measured as rearrangements at the molecular level and rejoining that contributes to cell survival.

Singh, Sheetal; Le Hongan; Shih, S.-J.; Ho, Bay [Department of Radiation Oncology, University of California at Davis, 4501 X St., Sacramento, California 95817 (United States); Vaughan, Andrew T., E-mail: andrew.vaughan@ucdmc.ucdavis.ed [Department of Radiation Oncology, University of California at Davis, 4501 X St., Sacramento, California 95817 (United States); Department of Veterans Affairs, Mather, California 95655 (United States)

2010-02-01T23:59:59.000Z

16

Low Dose Radiation Research Program: Quantification of Repair of  

NLE Websites -- All DOE Office Websites (Extended Search)

Quantification of Repair of Low-Dose-Induced DNA Double-Strand Quantification of Repair of Low-Dose-Induced DNA Double-Strand Breaks in Diploid Human Cells Authors: David Schild,1 and Larry H. Thompson,2 Institutions: 1Life Sciences Division, Lawrence Berkeley National Laboratory; and 2BBR Program, Lawrence Livermore National Laboratory Double-strand breaks (DSBs) are the biochemical lesions of primary concern in radiation related health effects. Compelling evidence from rodent and chicken model systems indicates that homologous recombinational repair (HRR) plays an essential role for cell viability in the repair of spontaneous DSBs arising during DNA replication and an important role in the repair of IR-induced DSBs. IR-induced DSBs are also repaired by error-prone nonhomologous end joining (NHEJ). Using hTERT-immortalized

17

Co-localisation of ?-H2AX and 53BP1 to sites of DNA double strand...  

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-H2AX and 53BP1 to sites of DNA double strand breaks following low- and high-LET irradiation of mammalian cells Jennifer Anderson, Jane Harper, 1 Frank Cucinotta, 2 Janice...

18

Solid phase sequencing of double-stranded nucleic acids  

DOE Patents (OSTI)

This invention relates to methods for detecting and sequencing of target double-stranded nucleic acid sequences, to nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probe comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Nucleic acids whose sequences can be determined include nucleic acids in biological samples such as patient biopsies and environmental samples. Probes may be fixed to a solid support such as a hybridization chip to facilitate automated determination of molecular weights and identification of the target sequence.

Fu, Dong-Jing (Waltham, MA); Cantor, Charles R. (Boston, MA); Koster, Hubert (Concord, MA); Smith, Cassandra L. (Boston, MA)

2002-01-01T23:59:59.000Z

19

Low Dose Radiation Induced DNA Damage Signaling and Repair Responses in  

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Induced DNA Damage Signaling and Repair Responses in Induced DNA Damage Signaling and Repair Responses in Human 3-Dimensional Skin Model System Yanrong Su, Jarah Meador and Adayabalam S. Balajee Center for Radiological Research, College of Physicians and Surgeons, Columbia University, 630 West, 168th Street, New York, NY 10032. Exposure to ionizing radiation (IR) inflicts a wide variety of lesions in the genomic DNA. Among them, DNA double strand break (DSB) is considered to be the critical lesion for most of the deleterious radiation effects including carcinogenesis. Much of our knowledge on induction and repair kinetics of DSB has come from studies in two dimensional cell culture systems. However, the damage signaling and repair responses to DSB in tissue microenvironment are largely unknown. Knowledge of tissue responses to

20

Velocity and processivity of helicase unwinding of double-stranded nucleic acids  

E-Print Network (OSTI)

Helicases are molecular motors which unwind double-stranded nucleic acids (dsNA) in cells. Many helicases move with directional bias on single-stranded (ss) nucleic acids, and couple their directional translocation to strand separation. A model of the coupling between translocation and unwinding uses an interaction potential to represent passive and active helicase mechanisms. A passive helicase must wait for thermal fluctuations to open dsNA base pairs before it can advance and inhibit NA closing. An active helicase directly destabilizes dsNA base pairs, accelerating the opening rate. Here we extend this model to include helicase unbinding from the nucleic-acid strand. The helicase processivity depends on the form of the interaction potential. A passive helicase has a mean attachment time which does not change between ss translocation and ds unwinding, while an active helicase in general shows a decrease in attachment time during unwinding relative to ss translocation. In addition, we describe how helicase u...

Betterton, M D; Julicher, Frank

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Intermediate States of Ribonuclease III in Complex with Double-Stranded RNA  

SciTech Connect

Bacterial ribonuclease III (RNase III) can affect RNA structure and gene expression in either of two ways: as a processing enzyme that cleaves double-stranded (ds) RNA, or as a binding protein that binds but does not cleave dsRNA. We previously proposed a model of the catalytic complex of RNase III with dsRNA based on three crystal structures, including the endonuclease domain of RNase III with and without bound metal ions and a dsRNA binding protein complexed with dsRNA. We also reported a noncatalytic assembly observed in the crystal structure of an RNase III mutant, which binds but does not cleave dsRNA, complexed with dsRNA. We hypothesize that the RNase III {center_dot} dsRNA complex can exist in two functional forms, a catalytic complex and a noncatalytic assembly, and that in between the two forms there may be intermediate states. Here, we present four crystal structures of RNase III complexed with dsRNA, representing possible intermediates.

Gan, Jianhua; Tropea, Joseph E.; Austin, Brian P.; Court, Donald L.; Waugh, David S.; Ji, Xinhua (NIH)

2010-07-19T23:59:59.000Z

22

Velocity and processivity of helicase unwinding of double-stranded nucleic acids  

E-Print Network (OSTI)

Helicases are molecular motors which unwind double-stranded nucleic acids (dsNA) in cells. Many helicases move with directional bias on single-stranded (ss) nucleic acids, and couple their directional translocation to strand separation. A model of the coupling between translocation and unwinding uses an interaction potential to represent passive and active helicase mechanisms. A passive helicase must wait for thermal fluctuations to open dsNA base pairs before it can advance and inhibit NA closing. An active helicase directly destabilizes dsNA base pairs, accelerating the opening rate. Here we extend this model to include helicase unbinding from the nucleic-acid strand. The helicase processivity depends on the form of the interaction potential. A passive helicase has a mean attachment time which does not change between ss translocation and ds unwinding, while an active helicase in general shows a decrease in attachment time during unwinding relative to ss translocation. In addition, we describe how helicase unwinding velocity and processivity vary if the base-pair binding free energy is changed.

M. D. Betterton; Frank Julicher

2005-09-15T23:59:59.000Z

23

Low Dose Radiation Research Program: Checkpoint Responses and Repair of a  

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Checkpoint Responses and Repair of a Broken Chromosome in Budding Checkpoint Responses and Repair of a Broken Chromosome in Budding Yeast. Authors: André Walther, Mreshwar B. Vaze, Anna Malkova, Grzegorz Ira, Xuan Wang, Jung-Ae Kim, Neal Sugawara, James E. Haber Brandeis University, Waltham, Massachusetts We have studied how yeast cells respond to the creation of a single double-strand break (DSB) by using a site-specific endonuclease to create one (or more) DSBs. In collaboration with R. Schroff, M. Licheten and W. Bonner (NIH) we have shown that a single DSB rapidly becomes associated with histone H2AX-phosphorylation (y-H2AX) covering a distance of about 25 kb on either side of the DSB. The drop-off in phosphorylation is not attributable to specific boundary sequences. y-H2AX can be phosphorylated by either ATR (Mec1) or ATM (Tel1) protein kinases. A mutation that removes

24

Mechanistic studies of bleomycin-mediated double-stranded DNA cleavage and structural studies of DNA containing normal and 4'-oxidized abasic sites  

E-Print Network (OSTI)

In order to examine the role of partial intercalation in double-stranded (ds) DNA cleavage mediated by a single bleomycin (BLM), a bulky group ([-cyclodextrin) was chemically attached to the polyamine tail of BLM A5 to ...

Chen, Jingyang, Ph. D. Massachusetts Institute of Technology

2006-01-01T23:59:59.000Z

25

1999 Gordon Research Conference on Mammalian DNA Repair. Final Progress Report  

SciTech Connect

This Conference will examine DNA repair as the key component in genomic surveillance that is so crucial to the overall integrity and function of mammalian cells. Recent discoveries have catapulted the field of DNA repair into a pivotal position for fundamental investigations into oncology, aging, environmental health, and developmental biology. We hope to highlight the most promising and exciting avenues of research in robust discussions at this conference. This Mammalian DNA Repair Gordon Conference differs from the past conferences in this series, in which the programs were broader in scope, with respect to topics and biological systems covered. A conference sponsored by the Genetics Society in April 1998 emphasized recombinational mechanisms for double-strand break repair and the role of mismatch repair deficiency in colorectal cancer. These topics will therefore receive somewhat less emphasis in the upcoming Conference. In view of the recent mechanistic advances in mammalian DNA repair, an upcoming comprehensive DNA repair meeting next autumn at Hilton Head; and the limited enrollment for Gordon Conferences we have decided to focus session-by-session on particular areas of controversy and/or new developments specifically in mammalian systems. Thus, the principal presentations will draw upon results from other cellular systems only to the extent that they impact our understanding of mammalian DNA repair.

1999-02-12T23:59:59.000Z

26

KUB5/HERA: a dual acting protein that suppresses genomic instability and promotes DNA repair after low dose IR exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

KUB5/HERA: a dual acting protein that suppresses genomic instability and KUB5/HERA: a dual acting protein that suppresses genomic instability and promotes DNA repair after low dose IR exposure Julio C. Morales 1 , Amy Rommel 1 , Konstantin Leskov 2 , Walter M. Hittelman 3 , David A. Boothman 1# 1 Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. 2 Department of Radiation Oncology, Case Western Reserve University, Cleveland, OH 44106, USA. 3 Department of Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX 77030, USA. # To whom correspondence should be addressed. E-mail: David.Boothman@utsouthwestern.edu Eukaryotic cells can respond to DNA double strand breaks created by low doses of IR by activating homologous recombination (HR) or non-homologous end- joining (NHEJ) pathways to repair DNA. A yeast two-hybrid screen using Ku70 as

27

Breaking  

NLE Websites -- All DOE Office Websites (Extended Search)

2 Volume 9 Issue 3 2 Volume 9 Issue 3 Closer kin for reference . . . . . . . . . . . . . . . . . . . . . . . 2 Breaking down pulp . . . . . . . . . . . . . . . . . . . . . . . . . 3 Single-cell genomics at the DOE JGI . . . . . . . . . . . . 4 In the news . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-7 also in this issue MASSIE SANTOS BALLON The Department of Energy focuses on a variety of alternative energy sources rather than putting all its eggs in one basket. At the recently concluded 7th annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held June 5-7, 2012, a similar message came through as speakers discussed combining sequencing platforms and conducting hybrid assemblies to produce more useful data in the form of finished genome sequences. Since the first Sequencing in the Future Meeting held in Santa Fe, New Mexico seven years ago, the number of attendees has increased each year from a starting group of 70, reaching a

28

Inhibition of Plasmodium falciparum proliferation in vitro by double-stranded RNA directed against malaria histone deacetylase  

SciTech Connect

Acetylation and deacetylation of histones play important roles in transcription regulation, cell cycle progression and development events. The steady state status of histone acetylation is controlled by a dynamic equilibrium between competing histone acetylase and deacetylase (HDAC). We have used long PfHDAC-1 double-stranded (ds)RNA to interfere with its cognate mRNA expression and determined the effect on malaria parasite growth and development. Chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 strain was exposed to 1-25 {mu}g of dsRNA/ml of culture for 48 h and growth was determined by [{sup 3}H]-hypoxanthine incorporation and microscopic examination. Parasite culture treated with 10 {mu}g/ml pfHDAC-1 dsRNA exhibited 47% growth inhibition when compared with either untreated control or culture treated with an unrelated dsRNA. PfHDAC-1 dsRNA specifically blocked maturation of trophozoite to schizont stages and decreased PfHDAC-1 transcript 44% in treated trophozoites. These results indicate the potential of HDAC-1 as a target for development of novel antimalarials.

Sriwilaijaroen, N. [Faculty of Medicine, Thammasat University (Rangsit Campus), Pathumthani 12120 (Thailand); Boonma, S. [Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400 (Thailand); Attasart, P. [Institute of Molecular Biology and Genetics, Mahidol University, Salaya, Nakornpathom 73170 (Thailand); Pothikasikorn, J. [Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400 (Thailand); Panyim, S. [Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400 (Thailand); Institute of Molecular Biology and Genetics, Mahidol University, Salaya, Nakornpathom 73170 (Thailand); Noonpakdee, W. [Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400 (Thailand)], E-mail: scwnp@mahidol.ac.th

2009-04-03T23:59:59.000Z

29

Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin  

Science Conference Proceedings (OSTI)

In order to investigate the mechanism of radio-sensitization by an Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG), we studied repair of DNA double strand breaks (DSBs) in irradiated human cells pre-treated with 17-AAG. DSBs are thought to be the critical target for radiation-induced cell death. Two human tumor cell lines DU145 and SQ-5 which showed clear radio-sensitization by 17-AAG revealed a significant inhibition of DSB repair, while normal human cells which did not show radio-sensitization by the drug indicated no change in the DSB repair kinetics with 17-AAG. We further demonstrated that BRCA2 was a novel client protein for Hsp90, and 17-AAG caused the degradation of BRCA2 and in turn altered the behavior of Rad51, a critical protein for homologous recombination (HR) pathway of DSB repair. Our data demonstrate for the first time that 17-AAG inhibits the HR repair process and could provide a new therapeutic strategy to selectively result in higher tumor cell killing.

Noguchi, Miho [Graduate School of Science and Technology, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan); Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555 (Japan); Yu, Dong [Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555 (Japan); Hirayama, Ryoichi [Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555 (Japan); Ninomiya, Yasuharu [Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555 (Japan); Sekine, Emiko [Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555 (Japan); Kubota, Nobuo [Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, 4669-2 Ami, Ami-machi, Inashiki-gun, Ibaraki 300-0394 (Japan); Ando, Koichi [Graduate School of Science and Technology, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan); Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555 (Japan); Okayasu, Ryuichi [Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555 (Japan)]. E-mail: rokayasu@nirs.go.jp

2006-12-22T23:59:59.000Z

30

TopBP1 associates with NBS1 and is involved in homologous recombination repair  

SciTech Connect

TopBP1 is involved in DNA replication and DNA damage checkpoint. Recent studies have demonstrated that TopBP1 is a direct positive effecter of ATR. However, it is not known how TopBP1 recognizes damaged DNA. Here, we show that TopBP1 formed nuclear foci after exposure to ionizing radiation, but such TopBP1 foci were abolished in Nijmegen breakage syndrome cells. We also show that TopBP1 physically associated with NBS1 in vivo. These results suggested that NBS1 might regulate TopBP1 recruitment to the sites of DNA damage. TopBP1-depleted cells showed hypersensitivity to Mitomycin C and ionizing radiation, an increased frequency of sister-chromatid exchange level, and a reduced frequency of DNA double-strand break induced homologous recombination repair. Together, these results suggested that TopBP1 might be a mediator of DNA damage signaling from NBS1 to ATR and promote homologous recombination repair.

Morishima, Ken-ichi [Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553 (Japan); Sakamoto, Shuichi; Kobayashi, Junya [Department of Genome Dynamics, Radiation Biology Center, Kyoto University, Kyoto 606-8501 (Japan); Izumi, Hideki; Suda, Tetsuji; Matsumoto, Yoshiyuki [Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553 (Japan); Tauchi, Hiroshi [Department of Environmental Sciences, Ibaraki University, Mito, Ibaraki 310-8512 (Japan); Ide, Hiroshi [Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8562 (Japan); Komatsu, Kenshi [Department of Genome Dynamics, Radiation Biology Center, Kyoto University, Kyoto 606-8501 (Japan); Matsuura, Shinya [Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553 (Japan)], E-mail: shinya@hiroshima-u.ac.jp

2007-11-03T23:59:59.000Z

31

WHERE MULTIFUNCTIONAL DNA REPAIR PROTEINS MEET: MAPPING THE INTERACTION DOMAINS BETWEEN XPG AND WRN  

Science Conference Proceedings (OSTI)

The rapid recognition and repair of DNA damage is essential for the maintenance of genomic integrity and cellular survival. Multiple complex and interconnected DNA damage responses exist within cells to preserve the human genome, and these repair pathways are carried out by a specifi c interplay of protein-protein interactions. Thus a failure in the coordination of these processes, perhaps brought about by a breakdown in any one multifunctional repair protein, can lead to genomic instability, developmental and immunological abnormalities, cancer and premature aging. This study demonstrates a novel interaction between two such repair proteins, Xeroderma pigmentosum group G protein (XPG) and Werner syndrome helicase (WRN), that are both highly pleiotropic and associated with inherited genetic disorders when mutated. XPG is a structure-specifi c endonuclease required for the repair of UV-damaged DNA by nucleotide excision repair (NER), and mutations in XPG result in the diseases Xeroderma pigmentosum (XP) and Cockayne syndrome (CS). A loss of XPG incision activity results in XP, whereas a loss of non-enzymatic function(s) of XPG causes CS. WRN is a multifunctional protein involved in double-strand break repair (DSBR), and consists of 3’–5’ DNA-dependent helicase, 3’–5’ exonuclease, and single-strand DNA annealing activities. Nonfunctional WRN protein leads to Werner syndrome, a premature aging disorder with increased cancer incidence. Far Western analysis was used to map the interacting domains between XPG and WRN by denaturing gel electrophoresis, which separated purifi ed full length and recombinant XPG and WRN deletion constructs, based primarily upon the length of each polypeptide. Specifi c interacting domains were visualized when probed with the secondary protein of interest which was then detected by traditional Western analysis using the antibody of the secondary protein. The interaction between XPG and WRN was mapped to the C-terminal region of XPG as well as the C-terminal region of WRN. The physical interaction between XPG and WRN links NER, (made evident by the disease XP) with DSBR, which imparts additional knowledge of the overlapping nature of these two proteins and the previously distinct DNA repair pathways they are associated with. Since genomic integrity is constantly threatened by both endogenous and exogenous (internal and external) damage, understanding the roles of these proteins in coordinating DNA repair processes with replication will signifi cantly further understanding how defects instigate physiological consequences in response to various DNA damaging sources. This ultimately contributes to our understanding of cancer and premature aging.

Rangaraj, K.; Cooper, P.K.; Trego, K.S.

2009-01-01T23:59:59.000Z

32

The human actin-related protein hArp5: Nucleo-cytoplasmic shuttling and involvement in DNA repair  

Science Conference Proceedings (OSTI)

Certain actin-related proteins (Arps) of budding yeast are localized in the nucleus, and have essential roles as stoichiometric components of histone acetyltransferase (HAT) and chromatin remodeling complexes. On the other hand, identification of vertebrate nuclear Arps and their functional analyses are just beginning. We show that human Arp5 (hArp5) proteins are localized in the nucleus, and that arp5{delta} yeast cells are partially complemented by hArp5. Thus, hArp5 is a novel member of the nuclear Arps of vertebrates, which possess evolutionarily conserved functions from yeast to humans. We show here that hArp5 shuttles between the nucleus and the cytoplasm. Furthermore, after the induction of DNA double strand breaks (DSB), cell growth and the accumulation of phosphorylated histone H2AX ({gamma}-H2AX) are impaired by hArp5 depletion. Association of hArp5 with the hIno80 chromatin remodeling enzyme and decrease of chromatin-bound hIno80 by hArp5-depletion indicate that hArp5 may have a role in the recruitment of the hINO80 complex to chromatin. Overexpression of hArp5 and hIno80 enhanced {gamma}-H2AX accumulation. These observations suggest that hArp5 is involved in the process of DSB repair through the regulation of the chromatin remodelling machinery.

Kitayama, Kumiko; Kamo, Mariko [Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi 1-1, Aoba-ku, Sendai 981-8555 (Japan); Oma, Yukako [Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi 1-1, Aoba-ku, Sendai 981-8555 (Japan); Department of Molecular and Cellular Genetics, UMR7156 CNRS-ULP, University of Strasbourg, 67084 Strasbourg cedex (France); Matsuda, Ryo [Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi 1-1, Aoba-ku, Sendai 981-8555 (Japan); Uchida, Takafumi [Enzymology, Graduate School of Agricultural, Tohoku University, Tsutsumidori-Amamiyamachi 1-1, Aoba-ku, Sendai 981-8555 (Japan); Ikura, Tsuyoshi [Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryoumachi 2 2-1, Aoba-ku, Sendai 980-8575 (Japan); Tashiro, Satoshi [Department of Cellular Biology, Hiroshima University, Hiroshima 734-8553 (Japan); Ohyama, Takashi [Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480 (Japan); Winsor, Barbara [Department of Molecular and Cellular Genetics, UMR7156 CNRS-ULP, University of Strasbourg, 67084 Strasbourg cedex (France); Harata, Masahiko [Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi 1-1, Aoba-ku, Sendai 981-8555 (Japan)], E-mail: mharata@biochem.tohoku.ac.jp

2009-01-15T23:59:59.000Z

33

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation  

Science Conference Proceedings (OSTI)

Hepatitis C virus (HCV) infection is frequently associated with the development of hepatocellular carcinomas and non-Hodgkin's B-cell lymphomas. Nonstructural protein 3 (NS3) of HCV possesses serine protease, nucleoside triphosphatase, and helicase activities, while NS4A functions as a cofactor for the NS3 serine protease. Here, we show that HCV NS3/4A interacts with the ATM (ataxia-telangiectasia mutated), a cellular protein essential for cellular response to irradiation. The expression of NS3/4A caused cytoplasmic translocation of either endogenous or exogenous ATM and delayed dephosphorylation of the phosphorylated ATM and {gamma}-H2AX following ionizing irradiation. As a result, the irradiation-induced {gamma}-H2AX foci persisted longer in the NS3/4A-expressing cells. Furthermore, these cells showed increased comet tail moment in single-cell electrophoresis assay, indicating increased double-strand DNA breaks. The cells harboring an HCV replicon also exhibited cytoplasmic localization of ATM and increased sensitivity to irradiation. These results demonstrate that NS3/4A impairs the efficiency of DNA repair by interacting with ATM and renders the cells more sensitive to DNA damage. This effect may contribute to HCV oncogenesis.

Lai, Chao-Kuen; Jeng, King-Song [Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan (China); Machida, Keigo [Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2001 Zonal Avenue, Los Angeles, CA 90033 (United States); Cheng, Yi-Sheng [Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan (China); Lai, Michael M.C. [Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan (China); Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2001 Zonal Avenue, Los Angeles, CA 90033 (United States)], E-mail: michlai@gate.sinica.edu.tw

2008-01-20T23:59:59.000Z

34

The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice  

E-Print Network (OSTI)

Mitotic homologous recombination is a critical pathway for the repair of DNA double-strand breaks and broken replication forks. Although homologous recombination is generally error-free, recombination between misaligned ...

Wiktor-Brown, Dominika M

2007-01-01T23:59:59.000Z

35

Identification of Rad52 complexes reveals a functional link between...  

NLE Websites -- All DOE Office Websites (Extended Search)

Genetics and Microbiology, MSC08-4660, University of New Mexico School of Medicine, Albuquerque, NM 87131 Rad52 plays important roles in repairing DNA double-strand breaks in...

36

The mechanism of recA polA lethality: Suppression by RecA-independent recombination repair activated by the lexA(Def) mutation in Escherichia coli  

SciTech Connect

The mechanism of recA polA lethality in Escherichia coli has been studied. Complementation tests have indicated that both the 5{prime} {yields} 3{prime} exonuclease and the polymerization activities of DNA polymerase I are essential for viability in the absence of RecA protein, whereas the viability and DNA replication of DNA polymerase I-defective cells depend on the recombinase activity of RecA. An alkaline sucrose gradient sedimentation analysis has indicated that RecA has only a minor role in Okazaki fragment processing. Double-strand break repair is proposed for the major role of RecA in the absence of DNA polymerase I. The lexA(Def)::Tn5 mutation has previously been shown to suppress the temperature-sensitive growth of recA200(Ts) polA25::spc mutants. The lexA(Def) mutation can alleviate impaired DNA synthesis in the recA200(Ts) polA25::spc mutant cells at the restrictive temperature. recF{sup +} is essential for this suppression pathway, recJ and recQ mutations have minor but significant adverse effects on the suppression. The recA200(Ts) allele in the recA200(Ts) polA25::spc lexA(Def) mutant can be replaced by {Delta}recA, indicating that the lexA(Def)-induced suppression is RecA independent. lexA(Def) reduces the sensitivity of {Delta}recA polA25::spc cells to UV damage by {approximately}10{sup 4}-fold. lexA(Def) also restores P1 transduction proficiency to the {Delta}recA polA25::spc mutant to a level that is 7.3% of the recA{sup +} wild type. These results suggest that lexA(Def) activates a RecA-independent, RecF-dependent recombination repair pathway that suppresses the defect in DNA replication in recA polA double mutants. 52 refs., 7 figs., 5 tabs.

Cao, Yang; Kogoma, Tokio [Univ. of New Mexico Health Sciences Center, Albuquerque, NM (United States)

1995-04-01T23:59:59.000Z

37

DNA repair is the target of novel antibiotics  

E-Print Network (OSTI)

Lloyd, (2006) Rep and PriA helicase activities prevent RecAR. G. Lloyd, (2004) RecG helicase promotes DNA double-strandM. A. Petit, (2005) UvrD helicase, unlike Rep helicase,

Gunderson, Carl Wayne

2007-01-01T23:59:59.000Z

38

Fan Repair Guideline  

Science Conference Proceedings (OSTI)

The successful repair of a fan component is affected by a number of different factors. These include correctly assessing the root cause of failure, determining the best repair option, implementation of proper repair procedures, and compliance with applicable codes and standards. However, in many situations the proper solution is not clearly evident. The purpose of this document is to provide guidance in the area of induced draft / forced draft fan repair. Specifically, this document deals with the repair...

2002-08-15T23:59:59.000Z

39

Rapid road repair vehicle  

DOE Patents (OSTI)

Disclosed is a rapid road repair vehicle capable of moving over a surface to be repaired at near normal posted traffic speeds to scan for and find at the high rate of speed, imperfections in the pavement surface, prepare the surface imperfection for repair by air pressure and vacuum cleaning, applying a correct amount of the correct patching material to effect the repair, smooth the resulting repaired surface, and catalog the location and quality of the repairs for maintenance records of the road surface. The rapid road repair vehicle can repair surface imperfections at lower cost, improved quality, at a higher rate of speed than was not heretofor possible, with significantly reduced exposure to safety and health hazards associated with this kind of road repair activities in the past. 2 figs.

Mara, L.M.

1998-05-05T23:59:59.000Z

40

Lorentz Breaking and Gravity  

E-Print Network (OSTI)

Gravitational theories with Lorentz violation must account for a number of possible features in order to be consistent theoretically and phenomenologically. A brief summary of these features is given here. They include evasion of a no-go theorem, connections between spontaneous Lorentz breaking and diffeomorphism breaking, the appearance of massless Nambu-Goldstone modes and massive Higgs modes, and the possibility of a Higgs mechanism in gravity.

R. Bluhm

2013-07-22T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Repairing structurally complex data  

Science Conference Proceedings (OSTI)

We present a novel algorithm for repairing structurally complex data. Given an assertion that represents desired structural integrity constraints and a structure that violates them, the algorithm performs repair actions that mutate the given structure ...

Sarfraz Khurshid; Iván García; Yuk Lai Suen

2005-08-01T23:59:59.000Z

42

Nanowire Micronetworks from Carbon-Black Nanoparticles | Advanced Photon  

NLE Websites -- All DOE Office Websites (Extended Search)

A Key Step in Repairing DNA Double-Strand Breaks A Key Step in Repairing DNA Double-Strand Breaks An X-ray Rainbow An Insulating Breakthrough Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Nanowire Micronetworks from Carbon-Black Nanoparticles JANUARY 11, 2007 Bookmark and Share Fig. 1. Diagram showing CB segregation to triple junctions during press sintering. Inset: USAXS image acquired from a press-sintered CB/PMMA sample with 1% CB mass fraction. Self-assembly is likely to play a decisive role in producing nanoscale elements for three dimensional (3D) electronic and nanoscale electro-mechanical systems. Until now, however, the difficult problem of fabricating a complex, interconnected 3D system of conductive nanoscale

43

Comments on the leak-before-break concept for nuclear power plant piping systems  

SciTech Connect

The leak-before-break concept is based on the idea that, with a high degree of probability, failure of the pressure boundary of piping systems will be signaled by a detectable leak that will provide ample time to shutdown and repair that leak. The status of the leak-before-break concept is discussed in this report, including a review of industrial and nuclear power plant experience with respect to leak-before-break, fracture mechanics, and potential elimination of postulated pipe breaks in nuclear power plant piping design. 36 refs., 12 figs., 3 tabs.

Rodabaugh, E.C.

1985-08-01T23:59:59.000Z

44

Chapter 11 Forecasting breaks and forecasting during breaks  

E-Print Network (OSTI)

Success in accurately forecasting breaks requires that they are predictable from relevant information available at the forecast origin using an appropriate model form, which can be selected and estimated before the break. To clarify the roles of these six necessary conditions, we distinguish between the information set for ‘normal forces ’ and the one for ‘break drivers’, then outline sources of potential information. Relevant non-linear, dynamic models facing multiple breaks can have more candidate variables than observations, so we discuss automatic model selection. As a failure to accurately forecast breaks remains likely, we augment our strategy by modelling breaks during their progress, and consider robust forecasting devices.

Jennifer L. Castle; Nicholas W. P. Fawcett; David F. Hendry

2011-01-01T23:59:59.000Z

45

Breaking Down the Barriers  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Breaking Down the Barriers Breaking Down the Barriers Engaging Agency Legal Resources to be Part of the Solution Daniel Gore US Coast Guard Energy Manager X ESPC ISC Kodiak ESPC/UESC Unit Contract Type Coast Guard Alternatively Financed Project Status Estimated Contract Value (Millions) Under Consideration Initial Proposal Delayed by lack of Contracting Officer or Champion Detailed Design Study Recently Awarded TRACEN Cape May ESPC X TRACEN Petaluma PPA X X ISC San Pedro UESC X X CG Academy ESPC X TRACEN Cape May UESC X Air Station Borenquin ESPC X X Sector New York (3 sites) ESPC X X CG Yard (BAMF) ESPC X E-City ESPC X West Coast - 9 Sites ESPC X Five Essentials for Alt. Financed Project * Site approval * Technical Champion * Contracting Officer * Financial Analyst * Legal Support

46

Diffusive Transport by Breaking Waves  

Science Conference Proceedings (OSTI)

A simple conceptual model of the relationship between advective transport by breaking waves and diffusive transport is derived. line model postulates that the displacement of fluid parcels by a breaking wave is analogous to molecular diffusion (...

Kenneth P. Bowman

1995-07-01T23:59:59.000Z

47

$R$-Parity Breaking Phenomenology  

E-Print Network (OSTI)

We review various features of the $R$-parity breaking phenomenology, with particular attention to the low energy observables, and to the patterns of the $R$-parity breaking interactions that arise in Grand Unified models.

Francesco Vissani

1996-02-26T23:59:59.000Z

48

Energy Loss by Breaking waves  

Science Conference Proceedings (OSTI)

Observations of the frequency of wind wave breaking in deep water are combined with laboratory estimates of the rate of energy loss a from single breaking wave to infer the net rate of energy transfer to the mixed layer from breaking waves, as a ...

S. A. Thorpe

1993-11-01T23:59:59.000Z

49

INTERNAL REPAIR OF PIPELINES  

Science Conference Proceedings (OSTI)

The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. In lieu of a field installation on an abandoned pipeline, a preliminary nondestructive testing protocol is being developed to determine the success or failure of the fiber-reinforced liner pipeline repairs. Optimization and validation activities for carbon-fiber repair methods are ongoing.

Bill Bruce; Nancy Porter; George Ritter; Matt Boring; Mark Lozev; Ian Harris; Bill Mohr; Dennis Harwig; Robin Gordon; Chris Neary; Mike Sullivan

2005-07-20T23:59:59.000Z

50

INTERNAL REPAIR OF PIPELINES  

Science Conference Proceedings (OSTI)

The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. The first round of optimization and validation activities for carbon-fiber repairs are complete. Development of a comprehensive test plan for this process is recommended for use in the field trial portion of this program.

Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

2004-12-31T23:59:59.000Z

51

INTERNAL REPAIR OF PIPELINES  

Science Conference Proceedings (OSTI)

The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. Development of a comprehensive test plan for this process is recommended for use in the field trial portion of this program.

Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

2004-08-17T23:59:59.000Z

52

Low Dose Radiation Research Program Publications  

NLE Websites -- All DOE Office Websites (Extended Search)

for medical exposures. Environmental and Molecular Mutagenesis 53(4): 247259 Lynn Hlatky ( 2012) Double-Strand Break Motions Shift Radiation Risk Notions?. PNAS...

53

Gravitational Waves from Supersymmetry Breaking  

E-Print Network (OSTI)

In theories of supersymmetry breaking, it is often the case that there is more than one metastable vacuum. First-order phase transitions among such metastable vacua may generate a stochastic background of gravitational waves, the observation of which would provide a direct window into the supersymmetry-breaking sector.

Craig, Nathaniel J

2009-01-01T23:59:59.000Z

54

Welding and Repair Technology Center: Repair Welding Handbook  

Science Conference Proceedings (OSTI)

During the life of a power plant, it often becomes necessary to perform weld repairs of various materials in order to continue safe operation. Much work has been completed in this area to assist utilities with choosing appropriate repair techniques based on the materials involved and the damage mechanism that makes the repair necessary. This report captures in one resource a variety of repair methods that have been proven to be effective.

2012-05-14T23:59:59.000Z

55

Repairs of Deaerators  

Science Conference Proceedings (OSTI)

This report provides a brief background of deaerator operation, including types of deaerators. Materials of construction are reviewed along with inspection, failure mechanisms, and repair methods. Some general information is provided to calculate minimum wall to see if deaerators are suitable for continued operation with defects in place.

2004-06-29T23:59:59.000Z

56

R parity can spontaneously break  

E-Print Network (OSTI)

We refute the claims made by Chaichian and Smilga in a recent paper in Phys Rev Letters on the impossibility of spontaneous R Parity breaking. Apart from explaining their error we summarize the results of a more detailed work that demonstrates explicitly that R parity can break spontaneously at a scale anywhere in the range 10 GeV to 1 Tev in a simple extension of the minimal SUSY standard model proposed previously.

J C Romao; C A Santos; J W F Valle

1992-05-06T23:59:59.000Z

57

NERSC's Hopper Breaks Petaflops Barrier  

NLE Websites -- All DOE Office Websites (Extended Search)

NERSC's Hopper Breaks NERSC's Hopper Breaks Petaflops Barrier NERSC's Hopper Breaks Petaflops Barrier Ranks 5th in the World November 14, 2010 Media Contact: Jon Bashor, jbashor@lbl.gov, 510-486-5849 hopper1.jpg NERSC's Cray XE6-Hopper BERKELEY, Calif.-The Department of Energy's National Energy Research Scientific Computing Center (NERSC), already one of the world's leading centers for scientific productivity, is now home to the fifth most powerful supercomputer in the world and the second most powerful in the United States, according to the latest edition of the TOP500 list, the definitive ranking of the world's top computers NERSC's newest supercomputer, a 153,408 processor-core Cray XE6 system, posted a performance of 1.05 petaflops (quadrillions of calculations per second) running the Linpack benchmark. In keeping with NERSC's tradition of

58

Chiral Symmetry Breaking in Graphene  

E-Print Network (OSTI)

The question of whether the Coulomb interaction is strong enough to break the sublattice symmetry of un-doped graphene is discussed. We formulate a strong coupling expansion where the ground state of the Coulomb Hamiltonian is found exactly and the kinetic hopping Hamiltonian is treated as a perturbation. We argue that many of the properties of the resulting system would be shared by graphene with a Hubbard model interaction. In particular, the best candidate sublattice symmetry breaking ground state is an antiferromagnetic Mott insulator. We discuss the results of some numerical simulations which indicate that the Coulomb interaction is indeed subcritical. We also point out the curious fact that, if the electron did not have spin degeneracy, the tendency to break chiral symmetry would be much greater and even relatively weak Coulomb interactions would likely gap the spectrum.

Gordon W. Semenoff

2011-08-15T23:59:59.000Z

59

Industrial motor repair in the United States  

Science Conference Proceedings (OSTI)

This report characterizes the motor repair industry in the United States; summarizes current motor repair and testing practice; and identifies barriers to energy motor repair practice and recommends strategies for overcoming those barriers.

Schueler, V.; Leistner, P.; Douglass, J.

1994-09-01T23:59:59.000Z

60

Observations of Breaking Surface Wave Statistics  

Science Conference Proceedings (OSTI)

Breaking surface waves were observed during the Surface Wave Process Program with a novel acoustical instrument that makes use of underwater ambient sound to track individual breaking events. The spatial and temporal statistics of braking waves ...

Li Ding; David M. Farmer

1994-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Breaking of Wind-Generated Waves  

Science Conference Proceedings (OSTI)

Breaking of wind-generated waves was studies in a laboratory tank. The critical surface slope and global wave steepness for inception of breaking were evaluated. Besides the frequency of occurrence, two other characteristic quantities, height and ...

Delun Xu; Paul A. Hwang; Jin Wu

1986-12-01T23:59:59.000Z

62

Inhomogeneous chiral symmetry breaking phases  

Science Conference Proceedings (OSTI)

We investigate inhomogeneous chiral symmetry breaking phases in the phase diagram of the two-flavor Nambu-Jona-Lasinio model, concentrating on phases with one-dimensional modulations. It is found that the first-order transition line in the phase diagram of homogeneous phases gets completely covered by an inhomogeneous phase which is bordered by second-order transition lines. The inhomogeneous phase turns out to be remarkably stable when vector interactions are included.

Buballa, M., E-mail: michael.buballa@physik.tu-darmstadt.de; Carignano, S., E-mail: carignano@crunch.ikp.physik.tu-darmstadt.de [Technische Universitaet Darmstadt, Institut fuer Kernphysik (Germany); Nickel, D., E-mail: mdjn@u.washington.edu [University of Washington, Institute for Nuclear Theory (United States)

2012-06-15T23:59:59.000Z

63

Chaotic inflation and supersymmetry breaking  

E-Print Network (OSTI)

We investigate the recently proposed class of chaotic inflation models in supergravity with an arbitrary inflaton potential. These models are extended to include matter fields in the visible sector and we employ a mechanism of SUSY breaking based on a particular phenomenological version of the KKLT mechanism (the KL model). We describe specific features of reheating in this class of models and show how one can solve the cosmological moduli and gravitino problems in this context.

Kallosh, Renata; Olive, Keith A; Rube, Tomas

2011-01-01T23:59:59.000Z

64

Chaotic inflation and supersymmetry breaking  

E-Print Network (OSTI)

We investigate the recently proposed class of chaotic inflation models in supergravity with an arbitrary inflaton potential. These models are extended to include matter fields in the visible sector and we employ a mechanism of SUSY breaking based on a particular phenomenological version of the KKLT mechanism (the KL model). We describe specific features of reheating in this class of models and show how one can solve the cosmological moduli and gravitino problems in this context.

Renata Kallosh; Andrei Linde; Keith A. Olive; Tomas Rube

2011-06-29T23:59:59.000Z

65

Welding and Repair Technology Center: Rolled Plate Repair Guide  

Science Conference Proceedings (OSTI)

This report is intended to enlighten and assist power plant engineers in the application of welded rolled plate repairs in both nuclear and balance-of-plant piping systems. This report introduces the engineer to post-construction standards in non-nuclear industries that use these types of repair, often on a widespread basis. Related requirements in those standards are explained in order to assist the engineer in planning and designing balance-of-plant repairs using welded rolled plates in various applica...

2011-12-23T23:59:59.000Z

66

Inspect and Repair Steam Traps  

SciTech Connect

This revised ITP tip sheet on inspecting and repairing steam traps provide how-to advice for improving industrial steam systems using low-cost, proven practices and technologies.

Not Available

2006-01-01T23:59:59.000Z

67

Two-dimensional warranty repair strategy based on minimal and complete repairs  

Science Conference Proceedings (OSTI)

For repairable products, the warrantor has options in choosing the degree of repair applied to an item that has failed within the warranty period. We focus on a particular warranty repair strategy, related to the degree of the warranty repair, for non-renewing, ... Keywords: Expected warranty servicing costs, Warranty, Warranty repair strategy

S. Chukova; M. R. Johnston

2006-12-01T23:59:59.000Z

68

Introduction to Electroweak Symmetry Breaking  

SciTech Connect

The Standard Model (SM) is the backbone of elementary particle physics-not only does it provide a consistent framework for studying the interactions of quark and leptons, but it also gives predictions which have been extensively tested experimentally. In these notes, I review the electroweak sector of the Standard Model, discuss the calculation of electroweak radiative corrections to observables, and summarize the status of SM Higgs boson searches. Despite the impressive experimental successes, however, the electroweak theory is not completely satisfactory and the mechanism of electroweak symmetry breaking is untested. I will discuss the logic behind the oft-repeated statement: 'There must be new physics at the TeV scale'. These lectures reflect my strongly held belief that upcoming results from the LHC will fundamentally change our understanding of electroweak symmetry breaking. In these lectures, I review the status of the electroweak sector of the Standard Model, with an emphasis on the importance of radiative corrections and searches for the Standard Model Higgs boson. A discussion of the special role of the TeV energy scale in electroweak physics is included.

Dawson,S.

2008-10-02T23:59:59.000Z

69

Dyes designed for high sensitivity detection of double-stranded DNA  

DOE Patents (OSTI)

Novel fluorescent dyes are provided, characterized by having a fluorophore joined to a cationic chain. The dyes are found to provide for high enhancement upon binding to nucleic acid and have strong binding affinities to the nucleic acid, as compared to the fluorophore without the polycationic chain. The dyes find use in detection of dsDNA in gel electrophoresis and solution at substantially higher sensitivities using substantially less dye.

Glazer, Alexander N. (Orinda, CA); Benson, Scott C. (Oakland, CA)

1998-01-01T23:59:59.000Z

70

Dyes designed for high sensitivity detection of double-stranded DNA  

DOE Patents (OSTI)

Novel fluorescent dyes are provided, characterized by having a fluorophore joined to a polycationic chain of at least two positive charges. The dyes are found to provide for high enhancement upon binding to nucleic acid and have strong binding affinities to the nucleic acid, as compared to the fluorophore without the polycationic chain. The dyes find use in detection of dsDNA in gel electrophoresis and solution at substantially higher sensitivities using substantially less dye.

Glazer, Alexander N. (Orinda, CA); Benson, Scott C. (Albany, CA)

1994-01-01T23:59:59.000Z

71

Dyes designed for high sensitivity detection of double-stranded DNA  

DOE Patents (OSTI)

Novel fluorescent dyes are provided, characterized by having a fluorophore joined to a cationic chain. The dyes are found to provide for high enhancement upon binding to nucleic acid and have strong binding affinities to the nucleic acid, as compared to the fluorophore without the polycationic chain. The dyes find use in detection of dsDNA in gel electrophoresis and solution at substantially higher sensitivities using substantially less dye.

Glazer, Alexander N. (Orinda, CA); Benson, Scott C. (Oakland, CA)

2000-01-01T23:59:59.000Z

72

Dyes designed for high sensitivity detection of double-stranded DNA  

DOE Patents (OSTI)

Novel fluorescent dyes are provided, characterized by having a fluorophore joined to a cationic chain. The dyes are found to provide for high enhancement upon binding to nucleic acid and have strong binding affinities to the nucleic acid, as compared to the fluorophore without the polycationic chain. The dyes find use in detection of dsDNA in gel electrophoresis and solution at substantially higher sensitivities using substantially less dye. 10 figs.

Glazer, A.N.; Benson, S.C.

1998-07-21T23:59:59.000Z

73

QCD, Symmetry Breaking and the Random Lattice  

E-Print Network (OSTI)

According to the Nielsen-Ninomiya No-Go theorem, the doubling of fermions on the lattice cannot be suppressed in a chiral theory. Whereas Wilson and staggered fermions suppress doublers with explicit breaking of chiral symmetry, the random lattice does so by spontaneous chiral symmetry breaking even in the free theory. I present results for meson masses, the chiral condensate and fermionic eigenvalues from simulations of quenched QCD on random lattices in four dimensions, focusing on chiral symmetry breaking. 1.

Saul D. Cohen A

2006-01-01T23:59:59.000Z

74

System Break-Out Session  

NLE Websites -- All DOE Office Websites (Extended Search)

Alkaline Membrane Fuel Cell Alkaline Membrane Fuel Cell Workshop System Break-Out Session Anil Trehan (CommScope) Huyen Dinh (NREL) 5/8 - 5/9/11 Washington DC Current State-of-art Performance * MEA level - 200 mW/cm2 peak power at 0.5 V, 60-65C * System level - Air-cooled 2 kW (net) - Energy density is advantage over incumbent battery and Gensets for stationary application - Significant price advantage over PEM fuel cells * Refer to CellEra and Tokuyama presentations for more details Application - Alcohol fuel small power levels Application Description Power range Military Remote sensor < 10 W Soldier Power 20- 50 W Battery charger 300 W Commercial Consumer electronics < 100 W Recreation < 500 W Commercial Application - Hydrogen Description Power range Back-up 1 - 10 kW Material Handling 1 - 10 kW Transportation

75

Degeneracy Breaking of Hydrogen Atom  

E-Print Network (OSTI)

The three dimensional rotation group, SO(3), is a symmetry group of the normal hydrogen atom. Each reducible representation of this group can be associated with a degenerate energy level. If this atom is placed in an external magnetic field, the interaction between the orbital magnetic moment with this field will lead to a symmetry breaking where the symmetry group of the atom is a new group distinct from the SO(3) group. This phenomenon describes the normal Zeeman effect, where a degenerate energy level splits into several new energy levels. It is explicitly shown that each of the new energy levels can be associated with an irreducible representation of the new symmetry group.

Agung Trisetyarso; Pantur Silaban

2008-12-22T23:59:59.000Z

76

Vanadium catalysts break down biomass for fuels  

NLE Websites -- All DOE Office Websites (Extended Search)

Vanadium catalysts break down biomass for fuels Vanadium catalysts break down biomass for fuels Vanadium catalysts break down biomass into useful components Breaking down biomass could help in converting biomass to fuels. March 26, 2012 Biomass Due to diminishing petroleum reserves, non-food biomass (lignocellulose) is an attractive alternative as a feedstock for the production of renewable chemicals and fuels. Get Expertise Researcher Susan Hanson Inorganic Isotope & Actinide Chem Email Researcher Ruilian Wu Bioenergy & Environmental Science Email Researcher Louis "Pete" Silks Bioenergy & Environmental Science Email Vanadium is an inexpensive, earth-abundant metal that is well suited for promoting oxidations in air. Vanadium catalysts break down biomass into useful components Due to diminishing petroleum reserves, non-food biomass (lignocellulose) is

77

Parsing speech repair without specialized grammar symbols  

Science Conference Proceedings (OSTI)

This paper describes a parsing model for speech with repairs that makes a clear separation between linguistically meaningful symbols in the grammar and operations specific to speech repair in the operation of the parser. This system builds a model of ...

Tim Miller; Luan Nguyen; William Schuler

2009-08-01T23:59:59.000Z

78

Localized Hardfacing Repair Techniques, RRAP45  

Science Conference Proceedings (OSTI)

Hardfacing overlays provide a hard, corrosive-resistant wear surface for critical valve, pump, and other component materials susceptible to one or more of the various wear mechanisms. As a result of being hard, these materials are also difficult to deposit and even more difficult to repair. When faced with a repair, owners either replace the hardfaced component or go through a time-consuming and difficult repair task. This report presents repair practices utilized by hardfacing alloy manufacturers, valve...

1997-12-19T23:59:59.000Z

79

Gas Turbine Component Repair Shop Capabilities  

Science Conference Proceedings (OSTI)

Aftermarket repair services for gas turbine OM has been undergoing continual transformation beginning with the emergence of independent shops in the 1980s. The original equipment manufacturers (OEMs) in the late 1990s began to aggressively pursue repair services. Gas turbine hot section component repair/replacement coupled with inspection/overhaul technical support has come to be offered as long-term service agreements (LTSAs). These agreements often extend from 6 to 18 years. The repair business continu...

2011-12-16T23:59:59.000Z

80

Safety, Capacity, Maintenance and Major Repairs (SCMMR) ...  

Science Conference Proceedings (OSTI)

... repairing and replacing aging mechanical and electrical ... and replacing or upgrading site utility systems; ... will avoid costly infrastructure failures such ...

2010-10-05T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Safety, Capacity, Maintenance, and Major Repair  

Science Conference Proceedings (OSTI)

... Continue repairing or replacing aging utility systems, exhaust and air ... Continue improvements to site infrastructure, including roads, loading docks ...

2010-10-05T23:59:59.000Z

82

Advances in Hydroelectric Turbine Manufacturing and Repair  

Science Conference Proceedings (OSTI)

About this Symposium. Meeting, Materials Science & Technology 2013. Symposium, Advances in Hydroelectric Turbine Manufacturing and Repair. Sponsorship ...

83

Dirac Neutrino Masses from Generalized Supersymmetry Breaking  

SciTech Connect

We demonstrate that Dirac neutrino masses in the experimentally preferred range are generated within supersymmetric gauge extensions of the standard model with a generalized supersymmetry breaking sector. If the superpotential neutrino Yukawa terms are forbidden by the gauge symmetry [such as a U(1){sup '}], sub-eV scale effective Dirac mass terms can arise at tree level from hard supersymmetry breaking Yukawa couplings, or at one loop due to nonanalytic soft supersymmetry breaking trilinear scalar couplings. The radiative neutrino magnetic and electric dipole moments vanish at one-loop order.

Demir, Durmus A.; Everett, Lisa L.; Langacker, Paul [Department of Physics, Izmir Institute of Technology, IZTECH, TR35430 Izmir (Turkey); Deutsches Elektronen-Synchrotron, DESY, D-22603 Hamburg (Germany); Department of Physics, University of Wisconsin, Madison, Wisconsin 53706 (United States); School of Natural Sciences, Institute for Advanced Study, Einstein Drive, Princeton, New Jersey 08540 (United States)

2008-03-07T23:59:59.000Z

84

Spontaneous chiral parity breaking by hydromagnetic buoyancy  

E-Print Network (OSTI)

Evidence for a parity-breaking nature of the magnetic buoyancy instability in a stably stratified gas is reported. In the absence of rotation, no helicity is produced, but the non-helical state is found to be unstable to small helical perturbations during the development of the instability. The parity-breaking nature of an instability in magnetohydrodynamics appears to be the first of its kind and is similar to chiral symmetry breaking in biochemistry. Applications to the production of mean fields in galaxy clusters are being discussed.

Chatterjee, Piyali; Brandenburg, Axel; Rheinhardt, Matthias

2010-01-01T23:59:59.000Z

85

Two Types of Wave Breaking in an Aquaplanet GCM  

Science Conference Proceedings (OSTI)

The characteristics of two distinct types of wave breaking in an aquaplanet general circulation model (GCM) are described. A systematic analysis of wave breaking is possible because when a baroclinic wave packet is present, the wave breaking ...

Sukyoung Lee; Steven Feldstein

1996-03-01T23:59:59.000Z

86

Appropriately handled prosodic breaks help PCFG parsing  

Science Conference Proceedings (OSTI)

This paper investigates using prosodic information in the form of ToBI break indexes for parsing spontaneous speech. We revisit two previously studied approaches, one that hurt parsing performance and one that achieved minor improvements, and propose ...

Zhongqiang Huang; Mary Harper

2010-06-01T23:59:59.000Z

87

Wave Breaking Dissipation Observed with “SWIFT” Drifters  

Science Conference Proceedings (OSTI)

Energy dissipation rates during ocean wave breaking are estimated from high-resolution profiles of turbulent velocities collected within 1 m of the surface. The velocity profiles are obtained from a pulse-coherent acoustic Doppler sonar on a wave-...

Jim Thomson

2012-12-01T23:59:59.000Z

88

Low Dose Radiation Research Program: Research Highlights - 2010  

NLE Websites -- All DOE Office Websites (Extended Search)

DNA Double-Strand Break Repair Capacities Before and After Exposure to Low DNA Double-Strand Break Repair Capacities Before and After Exposure to Low Dose Radiation Immunochemical detection of DSB foci in the nuclei of human fibroblasts. (A) γ-H2AX phospho-serine 139 foci (chromatin marker of DSBs; green). (B) ataxia-telangiectasia mutated phospho-serine 1981 foci (ATM, DNA damage-responsive kinase; red). (C) Merge of images A and B. (White arrows mark large γ-H2AX foci and coincident γ-H2AX/pATM foci that were positively scored; yellow arrows mark small γ-H2AX foci that lack corresponding pATM foci that were not scored.) Enlarge Image Immunochemical detection of DSB foci in the nuclei of human fibroblasts. (A) γ-H2AX phospho-serine 139 foci (chromatin marker of DSBs; green). (B) ataxia-telangiectasia mutated phospho-serine 1981 foci (ATM,

89

Deputy Secretary Poneman Attends Ground Breaking at Tennessee...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Home Deputy Secretary Poneman Attends Ground Breaking at Tennessee Advanced Vehicle Battery Plant Deputy Secretary Poneman Attends Ground Breaking at Tennessee Advanced Vehicle...

90

Modulated Tool-Path (MTP) Chip Breaking System  

Relationship between chip length, oscillation rate, and R Af . Modulated Tool-Path (MTP) Chip Breaking System 16 Fig. 11. MTP chip breaking surface fi nish model.

91

Low Dose Radiation Research Program: Assessing Biological Function of DNA  

NLE Websites -- All DOE Office Websites (Extended Search)

Assessing Biological Function of DNA Damage Response Genes Assessing Biological Function of DNA Damage Response Genes Larry H. Thompson Lawrence Livermore National Laboratory Why This Project To understand the relative importance of individual DNA repair and DNA-damage response pathways to the recovery of mammalian cells after exposure to low doses of ionizing radiation (IR). This understanding may lead to better ways of setting limits on human exposure to IR. In spite of the discovery of many mammalian DNA repair genes, our current knowledge of how many of these genes contribute to cellular recovery from IR exposure is quite limited. Project Goals Measure cellular responses at doses in the 5-100 cGy range, which generally cause changes too small to detect in normal, repair-proficient cells Focus on DNA double-strand breaks (DSBs) and DNA oxidative base

92

The Effect of Wave Breaking on the Wave Energy Spectrum  

Science Conference Proceedings (OSTI)

The effect of wave breaking on the wave energy spectral shape is examined. The Stokes wave-breaking criterion is first extended to random waves and a breaking wave model is established in which the elevation of breaking waves is expressed in ...

C. C. Tung; N. E. Huang

1987-08-01T23:59:59.000Z

93

Gas Turbine Repair Guidelines: Alstom GT26  

Science Conference Proceedings (OSTI)

For more than a decade, the Electric Power Research Institute (EPRI) has been developing gas turbine hot section component repair and coating guidelines to assist utilities and power generators in the refurbishment of these critical and expensive parts. Utilities, generators, and repair vendors have used these guidelines to perform repairs on turbine blades, vanes, and combustion hardware. The guidelines in this volume address the specific features of the Alstom GT26 gas turbine.

2011-11-03T23:59:59.000Z

94

Gas Turbine Repair Guidelines: GE 7FA  

Science Conference Proceedings (OSTI)

For more than a decade, the Electric Power Research Institute (EPRI) has been developing gas turbine hot section component repair and coating guidelines to assist utilities in the refurbishment of these critical and expensive parts. Utilities, generators, and repair vendors have used these guidelines to perform repairs on blades, turbine vanes, and combustion hardware. Guidelines now exist for a variety of conventional and advanced General Electric, Siemens/Westinghouse, Alstom, and Mitsubishi heavy fram...

2011-12-27T23:59:59.000Z

95

Gas Turbine Repair Guidelines: GE 9FA  

Science Conference Proceedings (OSTI)

For more than a decade, the Electric Power Research Institute (EPRI) has been developing gas turbine hot section component repair and coating guidelines to assist utilities in the refurbishment of these critical and expensive parts. Utilities, generators, and repair vendors have used these guidelines to perform repairs on blades, turbine vanes, and combustion hardware. Guidelines now exist for a variety of conventional and advanced General Electric, Siemens/Westinghouse, Alstom, and Mitsubishi heavy ...

2012-12-12T23:59:59.000Z

96

Alloy 600 Repairs with PTAW Process  

Science Conference Proceedings (OSTI)

Many utilities have Alloy 600 reactor vessel heads (RVHs) that are susceptible to primary water stress corrosion cracking (PWSCC), but have not cracked to date. This has prompted an exploration of repair and mitigation options to prevent future degradation of the RVH. Inconel 52 and Inconel 152, which are resistant to PWSCC, have been identified as potential repair alloys for Alloy 600 type repairs, and have been evaluated with the gas tungsten arc welding (GTAW) and shielded metal arc welding (SMAW) pro...

2003-06-27T23:59:59.000Z

97

Breaking Down Stovepipes | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Breaking Down Stovepipes Breaking Down Stovepipes Breaking Down Stovepipes Coordination with other DOE-wide teams and groups An assigned liaison to DOE's NEPA [National Environmental Policy Act] Six Sigma Team Coordination with the Facilities and Infrastructure Steering Committee: Ten-Year Site Plan requirements, streamlining processes for transferring facilities, work for others Communication across sites, programs, and communities to share lessons learned Kansas City Office coordinating with Oak Ridge and the Office of Environmental Management on the Bannister Federal Complex disposal lessons learned Office of Science sharing lessons on private industry opportunities to expand research capabilities at Oak Ridge and Brookhaven National Lab and on the use of opportunities offered by local government

98

Symmetry Breaking in Linearly Coupled Dynamical Lattices  

E-Print Network (OSTI)

We examine one- and two-dimensional (1D and 2D) models of linearly coupled lattices of the discrete-nonlinear-Schr{\\"{o}}dinger type. Analyzing ground states of the systems with equal powers in the two components, we find a symmetry-breaking phenomenon beyond a critical value of the squared $l^2$-norm. Asymmetric states, with unequal powers in their components, emerge through a subcritical pitchfork bifurcation, which, for very weakly coupled lattices, changes into a supercritical one. We identify the stability of various solution branches. Dynamical manifestations of the symmetry breaking are studied by simulating the evolution of the unstable branches. The results present the first example of spontaneous symmetry breaking in 2D lattice solitons. This feature has no counterpart in the continuum limit, because of the collapse instability in the latter case.

Herring, G; Malomed, B A; Carretero-González, R; Frantzeskakis, D J

2007-01-01T23:59:59.000Z

99

The Gordon conference on mammalian DNA repair  

SciTech Connect

A brief overview of the Gordon Conference on Mammalian Repair held February 1-5, 1993 in Ventura, California is presented.

Cleaver, J.E.; Smerdon, M.J.

1993-12-31T23:59:59.000Z

100

DNA purification by triplex-affinity capture and affinity capture electrophoresis  

DOE Patents (OSTI)

The invention provides a method for purifying or isolating double stranded DNA intact using triple helix formation. The method includes the steps of complexing an oligonucleotide and double stranded DNA to generate a triple helix and immobilization of the triple helix on a solid phase by means of a molecular recognition system such as avidin/biotin. The purified DNA is then recovered intact by treating the solid phase with a reagent that breaks the bonds between the oligonucleotide and the intact double stranded DNA while not affecting the Watson-Crick base pairs of the double helix. The present invention also provides a method for purifying or isolating double stranded DNA intact by complexing the double stranded DNA with a specific binding partner and recovering the complex during electrophoresis by immobilizing it on a solid phase trap imbedded in an electrophoretic gel. 6 figs.

Cantor, C.R.; Ito, Takashi; Smith, C.L.

1996-01-09T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

International congress on DNA damage and repair: Book of abstracts  

SciTech Connect

This document contains the abstracts of 105 papers presented at the Congress. Topics covered include the Escherichia coli nucleotide excision repair system, DNA repair in malignant transformations, defective DNA repair, and gene regulation. (TEM)

Not Available

1987-01-01T23:59:59.000Z

102

A gravity term from spontaneous symmetry breaking  

E-Print Network (OSTI)

In this model, the gravity term in the Lagrangean comes from spontaneous symmetry breaking of an additional scalar quadruplet field $\\Upsilon$. The resulting gravitational field is approximate to one of the models of coframe gravity with parameters $\\rho_1 + 4 \\rho_2 = 0$, $\\rho_3 = 0$. This article includes an exact solution of coframe gravity with model parameters $\\rho_1 \

Mihai Moise

2014-01-02T23:59:59.000Z

103

Facts and Myths of Enigma: breaking stereotypes  

Science Conference Proceedings (OSTI)

In spite of a relatively large number of publications about breaking Enigma by the Allies before and during the World War II, this subject remains relatively unknown not only to the general public, but also to people professionally involved in cryptological ... Keywords: Enigma, cipher machine, codebreaking, cryptanalytical bombe, rotor

Kris Gaj; Arkadiusz Or?owski

2003-05-01T23:59:59.000Z

104

NSLS Services | Repair & Equipment Services  

NLE Websites -- All DOE Office Websites (Extended Search)

Repair & Equipment Services Repair & Equipment Services Cleaning Facility (BNL Central Shops) Solvent cleaning of vacuum parts and leak checking service is also available. Work is billed to each user via a BNL ILR. Contact the NSLS Building Manager to arrange for any of these services. Electronics Repair Limited repairs for electronic equipment are available from an outside contractor through the Control Room. Contact Control Room Supervisor Randy Church (x2550 or x2736, pager 5310). Shipping memos are filled out on the web, and pick ups are on Fridays. Come to the Control Room for assistance. The user should call the contractor on the day before scheduled pickups to alert the contractor of the pickup. Items to be repaired should be left in the Control Room with the completed shipping memo. Costs are charged to the

105

Radiation Induced Chromatid-type Aberrations after Irradiation of Late-S/G2  

NLE Websites -- All DOE Office Websites (Extended Search)

Induced Chromatid-type Aberrations after Irradiation of Late-S/G2 Induced Chromatid-type Aberrations after Irradiation of Late-S/G2 Cells: Roles of Homologous Recombination and Non-Homologous End Joining Joel Bedford Colorado State University Abstract There has been considerable discussion, with some data reported, addressing the question of the relative contributions of non-homologous end joining (NHEJ) and homologous recombinational repair (HRR) on the repair or rejoining of radiation-induced DNA double strand breaks, especially in relation to their operation during the cell cycle. Reports have included studies on chromosomal aberration induction in G1/G0 cells defective in NHEJ or A-T cells, for example, but relatively little on S/G2 cells and especially on mutants defective in HRR. The broad biological importance of

106

Breaking the Fuel Cell Cost Barrier  

NLE Websites -- All DOE Office Websites (Extended Search)

Breaking the Fuel Cell Cost Barrier Breaking the Fuel Cell Cost Barrier AMFC Workshop May 8 th , 2011, Arlington, VA Shimshon Gottesfeld, CTO The Fuel Cell Cost Challenge 2 CellEra's goal - achieve price parity with incumbents earlier on in market entry process ! Mainstream Polymer Electrolyte Fuel Cell ( PEM) Cost Barriers 3 Graphite / stainless steel hardware Acidic membrane Platinum based electrodes Cost barriers deeply embedded in core tech materials BOM-based cost barriers - 90% of stack cost Cost volatility - Platinum $500/Oz - $2,500/Oz The possibility of an OH - ion conducting membrane 4 Non-acidic membrane CellEra Took Advantage of this Opportunity A new type of membrane component with potential for strong fuel cell cost cuts was revealed in 2006, but was accompanied by general industry skepticism

107

Breaking the Code of Cell Communication  

NLE Websites -- All DOE Office Websites (Extended Search)

Breaking the Code of Cell Communication Breaking the Code of Cell Communication A method that cells use to communicate and coordinate activities has been confirmed by researchers from Cornell University, Monsanto Co., and Argonne. This work could lead to new drugs for the fight against such diseases as cystic fibrosis and the bubonic plague, or to new technologies that perform useful environmental tasks such as filtering water. The structure of the key protein that enables quorum-sensing bacteria to communicate and spread infection. Above: The structure of the key protein that enables quorum-sensing bacteria to communicate and spread infection. Biologists have theorized that bacteria communicate by releasing and sensing chemical pheromones to detect their population densities, an activity called "quorum sensing." This theory was confirmed by

108

Simulation of Wave Breaking in One-Dimensional Spectral Environment  

Science Conference Proceedings (OSTI)

Results of numerical investigations, based on full dynamic equations, are presented for wave breaking in a one-dimensional environment with a wave spectrum. The breaking is defined as a process of irreversible collapse of an individual wave in ...

Dmitry Chalikov; Alexander V. Babanin

2012-11-01T23:59:59.000Z

109

Wave Breaking and Ocean Surface Layer Thermal Response  

Science Conference Proceedings (OSTI)

The effect of breaking waves on ocean surface temperatures and surface boundary layer deepening is investigated. The modification of the Mellor–Yamada turbulence closure model by Craig and Banner and others to include surface wave breaking ...

George Mellor; Alan Blumberg

2004-03-01T23:59:59.000Z

110

Spectral Energy Dissipation due to Surface Wave Breaking  

Science Conference Proceedings (OSTI)

A semiempirical determination of the spectral dependence of the energy dissipation due to surface wave breaking is presented and then used to propose a model for the spectral dependence of the breaking strength parameter b, defined in the O. M. ...

Leonel Romero; W. Kendall Melville; Jessica M. Kleiss

2012-09-01T23:59:59.000Z

111

Wave–Turbulence Interactions in a Breaking Mountain Wave  

Science Conference Proceedings (OSTI)

The mean and turbulent structures in a breaking mountain wave are considered through an ensemble of high-resolution (essentially large-eddy simulation) wave-breaking calculations. Of particular interest are the turbulent heat and momentum fluxes ...

Craig C. Epifanio; Tingting Qian

2008-10-01T23:59:59.000Z

112

Breaking Probability for Dominant Waves on the Sea Surface  

Science Conference Proceedings (OSTI)

The breaking probability is investigated for the dominant surface waves observed in three geographically diverse natural bodies of water: Lake Washington, the Black Sea, and the Southern Ocean. The breaking probability is taken as the average ...

Michael L. Banner; Alexander V. Babanin; Ian R. Young

2000-12-01T23:59:59.000Z

113

Textural break foundation wall construction modules  

SciTech Connect

Below-grade, textural-break foundation wall structures are provided for inhibiting diffusion and advection of liquids and gases into and out from a surrounding hydrogeologic environment. The foundation wall structure includes a foundation wall having an interior and exterior surface and a porous medium disposed around a portion of the exterior surface. The structure further includes a modular barrier disposed around a portion of the porous medium. The modular barrier is substantially removable from the hydrogeologic environment.

Phillips, Steven J. (Kennewick, WA)

1990-01-01T23:59:59.000Z

114

Depolarization remote sensing by orthogonality breaking  

E-Print Network (OSTI)

A new concept devoted to sensing the depolarization strength of materials from a single measurement is proposed and successfully validated on a variety of samples. It relies on the measurement of the orthogonality breaking between two orthogonal states of polarization after interaction with the material to be characterized. The two fields orthogonality being preserved after propagation in birefringent media, this concept is shown to be perfectly suited to depolarization remote sensing through fibers, opening the way to real time depolarization endoscopy.

Fade, Julien

2012-01-01T23:59:59.000Z

115

Transcriptional and Epigenetic Responses of Human Cells to Low Dose  

NLE Websites -- All DOE Office Websites (Extended Search)

Transcriptional and Epigenetic Responses of Human Cells to Low Dose Transcriptional and Epigenetic Responses of Human Cells to Low Dose Ionizing Radiation Identified through High Throughput ChIP-Seq Analysis Carl Anderson Brookhaven National Laboratory Abstract The major consequence of human exposures to ionizing radiation (IR) is considered to be an increased incidence of cancer (Brenner et al., 2003). Exposure of cells to 1 Gy of IR produces approximately 40 double-stranded breaks, 1000 single-stranded breaks, and 1000 damaged bases per genome equivalent (Pandita and Richardson, 2009); however, most direct DNA damage is rapidly repaired. Exposure to IR also induces epigenetic changes including both increases and decreases in DNA methylation, and increasing evidence suggests that epigenetic changes can both initiate cancer and

116

Welding and Repair Technology Center: Repair Technology for Degraded Pressure Vessel and Heat Exchanger Shells  

Science Conference Proceedings (OSTI)

BackgroundPressure vessels and heat exchangers are subject to a number of degradation mechanisms that can cause thinning of component walls and deterioration of internal components. With many repair options available, the Electric Power Research Institute (EPRI) Welding and Repair Technology Center (WRTC) has developed this report to assist operations and engineering personnel who are faced with defective or failed vessel components. Many available repair options allow ...

2013-10-30T23:59:59.000Z

117

DART: a data acquisition and repairing tool  

Science Conference Proceedings (OSTI)

An architecture is proposed providing robust data acquisition facilities from input documents containing tabular data. This architecture is based on a data-repairing framework exploiting integrity constraints defined on the input data to support the ...

Bettina Fazzinga; Sergio Flesca; Filippo Furfaro; Francesco Parisi

2006-03-01T23:59:59.000Z

118

The technical and economic success of repairable PDC bits  

Science Conference Proceedings (OSTI)

Repairable PDC bits have saved operators and contractors millions of dollars in bit costs alone. The repair of steel-bodied PDC bits has been going on for over 4 years but more recently, due to technical innovations, matrix body bits are becoming repairable. DBS was concerned when starting the repairability project that the quality of a repaired bit be close to that of a new bit. Conventional thinking had it that the repaired bit would at best be slightly inferior to a new bit. However, during our initial evaluation of repaired steel-bodied bits, the authors noticed that, remarkably, the repaired bits overall drilled more footage per run at a higher rate of penetration than new bits. After over 200 bits had been run, repaired, and rerun, in every case and for every bit style the average footage and ROP were slightly higher for the repaired bit.

Matson, L.; Stratabit, D.B.

1989-03-01T23:59:59.000Z

119

Breaking Criterion and Characteristics for Solitary Waves on Slopes  

E-Print Network (OSTI)

Shoaling and breaking of solitary waves is computed on slopes 1:100 to 1:8 using an experimentally validated fully nonlinear wave model based on potential flow equations. Characteristics of waves are computed at and beyond the breaking point, and geometric self-similarities of breakers are discussed as a function of wave height and bottom slope. No wave breaks for slopes steeper than 12 . A breaking criterion is derived for milder slopes, based on values of a nondimensional slope parameter o . This criterion predicts both whether waves will break or not and which type of breaking will occur (spilling, plunging, or surging). Empirical expressions for the breaking index and for the depth and celerity at breaking are derived based on computations. All results agree well with laboratory experiments. The NSW equations fail to predict these results with sufficient accuracy at the breaking point. Pre-breaking shoaling rates follow a more complex path than previously realized. Post-breaking behaviors exhibit a rapid (non-dissipative) decay, also observed in experiments, associated with a transfer of potential energy into kinetic energy. Wave celerity decreases in this zone of rapid decay.

S. T. Grilli; I.A. Svendsen; Member Asce; Member Asce; R. Subramanya

1997-01-01T23:59:59.000Z

120

Energy and Technology Review: Unlocking the mysteries of DNA repair  

SciTech Connect

DNA, the genetic blueprint, has the remarkable property of encoding its own repair following diverse types of structural damage induced by external agents or normal metabolism. We are studying the interplay of DNA damaging agents, repair genes, and their protein products to decipher the complex biochemical pathways that mediate such repair. Our research focuses on repair processes that correct DNA damage produced by chemical mutagens and radiation, both ionizing and ultraviolet. The most important type of DNA repair in human cells is called excision repair. This multistep process removes damaged or inappropriate pieces of DNA -- often as a string of 29 nucleotides containing the damage -- and replaces them with intact ones. We have isolated, cloned, and mapped several human repair genes associated with the nucleotide excision repair pathway and involved in the repair of DNA damage after exposure to ultraviolet light or mutagens in cooked food. We have shown that a defect in one of these repair genes, ERCC2, is responsible for the repair deficiency in one of the groups of patients with the recessive genetic disorder xeroderma pigmentosum (XP group D). We are exploring ways to purify sufficient quantities (milligrams) of the protein products of these and other repair genes so that we can understand their functions. Our long-term goals are to link defective repair proteins to human DNA repair disorders that predispose to cancer, and to produce DNA-repair-deficient mice that can serve as models for the human disorders.

Quirk, W.A.

1993-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

SUSY breaking from exotic U(1)  

SciTech Connect

We propose a mechanism that the soft supersymmetry breaking masses can be induced from the dynamical rearrangement of local U(1) symmetry in a five-dimensional model. The U(1) symmetry possesses several extraordinary features. The eigenstates of U(1) do not equal to those of boundary conditions. The U(1) charge of standard model particles does not equal to that of superpartners. A large U(1) charge hierarchy among superpartners and a standard model gauge singlet is necessary in order to obtain the masses of O(1)TeV.

Kawamura, Yoshiharu [Department of Physics, Shinshu University, Matsumoto 390-8621 (Japan)

2012-07-27T23:59:59.000Z

122

Involvement of DNA polymerase beta in repairing oxidative damages induced by antitumor drug adriamycin  

SciTech Connect

Adriamycin (ADM) is a widely used antineoplastic drug. However, the increasing cellular resistance has become a serious limitation to ADM clinical application. The most important mechanism related to ADM-induced cell death is oxidative DNA damage mediated by reactive oxygen species (ROS). Base excision repair (BER) is a major pathway in the repair of DNA single strand break (SSB) and oxidized base. In this study, we firstly applied the murine embryo fibroblasts wild-type (pol {beta} +/+) and homozygous pol {beta} null cell (pol {beta} -/-) as a model to investigate ADM DNA-damaging effects and the molecular basis underlying these effects. Here, cellular sensitivity to ADM was examined using colorimetric assay and colony forming assay. ADM-induced cellular ROS level and the alteration of superoxide dismutase (SOD) activity were measured by commercial kits. Further, DNA strand break, chromosomal damage and gene mutation were assessed by comet assay, micronucleus test and hprt gene mutation assay, respectively. The results showed that pol {beta} -/- cells were more sensitive to ADM compared with pol {beta} +/+ cells and more severe SSB and chromosomal damage as well as higher hprt gene mutation frequency were observed in pol {beta} -/- cells. ROS level in pol {beta} -/- cells increased along with decreased activity of SOD. These results demonstrated that pol {beta} deficiency could enable ROS accumulation with SOD activity decrease, further elevate oxidative DNA damage, and subsequently result in SSB, chromosome cleavage as well as gene mutation, which may be partly responsible for the cytotoxicity of ADM and the hypersensitivity of pol {beta} -/- cells to ADM. These findings suggested that pol {beta} is vital for repairing oxidative damage induced by ADM.

Liu Shukun; Wu Mei [Department of Environmental Health, Sichuan University, West China School of Public Health, Chengdu (China); Zhang Zunzhen, E-mail: zhangzunzhen@163.co [Department of Environmental Health, Sichuan University, West China School of Public Health, Chengdu (China)

2010-08-01T23:59:59.000Z

123

HYDROGEN EFFECTS ON LASER ENGINEERED NET SHAPE (LENS) REPAIRED WELDMENTS  

DOE Green Energy (OSTI)

New methods of repairing mis-machined components are always of interest. In this study, an innovative method using Laser Engineered Net Shape{trademark} (LENS{reg_sign}) forming was used to repair intentionally mis-machined test articles. The components were repaired and subsequently hydrogen charged and burst tested. The LENS repair did not have an adverse effect on the solid state weld process that was used to repair the components. Hydrogen charged samples failed in a similar manner to the uncharged samples. Overall, the prospects for LENS repairing similar products are favorable and further work is encouraged.

Korinko, P; Thad Adams, T

2006-10-06T23:59:59.000Z

124

Patterns of Spontaneous Chiral Symmetry Breaking in Vectorlike Gauge Theories  

E-Print Network (OSTI)

It has been conjectured that spontaneous chiral symmetry breaking in strongly coupled vectorlike gauge theories falls into only three different classes, depending on the gauge group and the representations carried by the fermions. We test this proposal by studying SU(2), SU(3) and SU(4) lattice gauge theories with staggered fermions in different irreducible representations. Staggered fermions away from the continuum limit should, for all complex representations, still belong to the continuum class of spontaneous symmetry breaking. But for all real and pseudo-real representations we show that staggered fermions should belong to incorrect symmetry breaking classes away from the continuum, thus generalizing previous results. As an unambiguous signal for whether chiral symmetry breaks, and which breaking pattern it follows, we look at the smallest Dirac eigenvalue distributions. We find that the patterns of symmetry breaking are precisely those conjectured.

P. H. Damgaard; U. M. Heller; R. Niclasen; B. Svetitsky

2008-01-01T23:59:59.000Z

125

FEM analysis of in-flight ice break-up  

Science Conference Proceedings (OSTI)

Using a fracture mechanics framework, this paper presents a finite element method to simulate the break-up of ice accreted on the wings of aircraft. The fully automated ice break-up module is integrated in FENSAP-ICE [1,2], which is an in-flight ice ... Keywords: Finite element methods, Fracture mechanics, Ice break-up, Ice shedding, In-flight icing, Multi-physics phenomenon

Shiping Zhang; Oubai El Kerdi; Rooh A. Khurram; Wagdi G. Habashi

2012-09-01T23:59:59.000Z

126

Holst action and Dynamical Electroweak symmetry breaking  

E-Print Network (OSTI)

We consider Poincare gravity coupled in a nonminimal way to spinors. The gravitational action is considered that contains both Palatini and Holst terms. Due to torsion the effective four - fermion interactions appear that may lead to the left - right asymmetry and the condensation of fermions. When the mass parameter entering the mentioned terms of the gravitational action is at a Tev scale the given construction may provide the dynamical Electroweak symmetry breaking. This is achieved via an arrangement of all Standard Model fermions in the left - handed Dirac spinors while the right - handed spinors are reserved for the technifermions. Due to the gravitational action the technifermions are condensed and, therefore, cause the appearance of gauge boson masses.

M. A. Zubkov

2010-04-08T23:59:59.000Z

127

A MASTER FORMULA FOR CHIRAL SYMMETRY BREAKING  

E-Print Network (OSTI)

We derive a master formula for chiral $SU(2)\\times SU(2)$ breaking, based on the Veltman-Bell equations and the Peierls-Dyson relation. Our approach does not rely on the use of the soft pion limit or an expansion around the chiral limit, and yields exact results for on-shell pions. Threshold theorems for $\\pi N\\rightarrow \\pi N$, $\\gamma N\\rightarrow \\pi N$, $\\pi N\\rightarrow\\pi\\pi N$, $\\gamma N\\rightarrow \\gamma\\pi N$, $\\gamma N\\rightarrow \\pi\\pi N$ and $\\pi N\\rightarrow \\pi\\gamma N$ are recovered, and corrections to them are given. The reactions $\\pi\\rightarrow e\

HIDENAGA YAMAGISHI; ISMAIL ZAHED

1995-03-22T23:59:59.000Z

128

Dynamical Local Chirality and Chiral Symmetry Breaking  

E-Print Network (OSTI)

We present some of the reasoning and results substantiating the notion that spontaneous chiral symmetry breaking (SChSB) in QCD is encoded in local chiral properties of Dirac eigenmodes. Such association is possible when viewing chirality as a dynamical effect, measured with respect to the benchmark of statistically independent left-right components. Following this rationale leads to describing local chiral behavior by a taylor-made correlation, namely the recently introduced correlation coefficient of polarization C_A. In this language, correlated modes (C_A>0) show dynamical preference for local chirality while anti-correlated modes (C_Aenergy correlation (chirality) over anti-correlation (anti-chirality) of Dirac sea. The spectral range of local chirality, chiral polarization scale Lambda_ch, is a dynamically generated scale in the theory associated with SChSB. One implication of these findings is briefly dis...

Alexandru, Andrei

2013-01-01T23:59:59.000Z

129

Modified Gravity via Spontaneous Symmetry Breaking  

E-Print Network (OSTI)

We construct effective field theories in which gravity is modified via spontaneous breaking of local Lorentz invariance. This is a gravitational analogue of the Higgs mechanism. These theories possess additional graviton modes and modified dispersion relations. They are manifestly well-behaved in the UV and free of discontinuities of the van Dam-Veltman-Zakharov type, ensuring compatibility with standard tests of gravity. They may have important phenomenological effects on large distance scales, offering an alternative to dark energy. For the case in which the symmetry is broken by a vector field with the wrong sign mass term, we identify four massless graviton modes (all with positive-definite norm for a suitable choice of a parameter) and show the absence of the discontinuity.

B. M. Gripaios

2004-08-17T23:59:59.000Z

130

Getting paid to break into things: Argonne's Roger Johnston on...  

NLE Websites -- All DOE Office Websites (Extended Search)

break into "foolproof" systems. Speakers Roger Johnston Duration 4:06 Topic Security Cyber security Vulnerability assessment Video ID http:youtu.befrBBGJqkz9E Credit NBC...

131

Statistical estimation of water distribution system pipe break risk.  

E-Print Network (OSTI)

??The deterioration of pipes in urban water distribution systems is of concern to water utilities throughout the world. This deterioration generally leads to pipe breaks… (more)

Yamijala, Shridhar

2009-01-01T23:59:59.000Z

132

First Mira Runs Break New Ground with Turbulence Simulations...  

NLE Websites -- All DOE Office Websites (Extended Search)

First Mira Runs Break New Ground with Turbulence Simulations July 16, 2013 Printer-friendly version Shortly after Mira, the ALCF's new 10-petaflops supercomputer, entered...

133

Symmetry Breaking of H2 Dissociation by a Single Photon  

NLE Websites -- All DOE Office Websites (Extended Search)

by breaking the molecular symmetry. A Molecular Paradox Symmetries in nature, such as the human body's bilateral symmetry and the snowflake's six-fold rotational symmetry, abound...

134

The Science of Surfing Waves and Surfing Breaks - A Review  

E-Print Network (OSTI)

affect breaking intensity. Offshore winds increase breakingbreaker intensity. Strong offshore winds make waves hard toThe perfect wind conditions for surfing are light offshore.

Scarfe, B. E.; Elwany, M. H.S.; Mead, S. T.; Black, K. P.

2003-01-01T23:59:59.000Z

135

DOE Joint Genome Institute: Breaking Biomass Better, DOE JGI...  

NLE Websites -- All DOE Office Websites (Extended Search)

12, 2010 Breaking Biomass Better: DOE JGI Sequences Wood Decaying Fungus to Advance Biofuels Prospects WALNUT CREEK, CA-One of the challenges in making cellulosic biofuels...

136

Safety Bulletin 2006-02, Natural Gas Line Breaks  

NLE Websites -- All DOE Office Websites (Extended Search)

Natural Gas Line Breaks PURPOSE This Bulletin provides information on a safety concern that may impact operations at Department of Energy (DOE) facilities. Specifically, the...

137

Valve Application, Maintenance, and Repair Guide  

Science Conference Proceedings (OSTI)

The Valve Application, Maintenance, and Repair Guide is a two-volume series that provides a generic overview of valve application, selection, maintenance, and repair. Volume 1 of the series is a comprehensive reference on the application and use of valves that provides guidance on the selection of specific types of valves on the basis of functional and system requirements. This document is based on an earlier EPRI document (NP-6516, Guide for the Application and Use of Valves in Power Plant Systems). Ext...

1999-05-07T23:59:59.000Z

138

Repairable chip bonding/interconnect process  

DOE Patents (OSTI)

A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules is disclosed. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder. 10 figs.

Bernhardt, A.F.; Contolini, R.J.; Malba, V.; Riddle, R.A.

1997-08-05T23:59:59.000Z

139

Repairable chip bonding/interconnect process  

DOE Patents (OSTI)

A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder.

Bernhardt, Anthony F. (Berkeley, CA); Contolini, Robert J. (Livermore, CA); Malba, Vincent (Livermore, CA); Riddle, Robert A. (Tracy, CA)

1997-01-01T23:59:59.000Z

140

Improved syntactic models for parsing speech with repairs  

Science Conference Proceedings (OSTI)

This paper introduces three new syntactic models for representing speech with repairs. These models are developed to test the intuition that the erroneous parts of speech repairs (reparanda) are not generated or recognized as such while occurring, but ...

Tim Miller

2009-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Survey of Gas Turbine Component Repair Shops - 2008 Update  

Science Conference Proceedings (OSTI)

Aftermarket repair services for gas turbine O&M has been undergoing continual transformation beginning with the emergence of independent shops in the 1980s. The original equipment manufacturers (OEMs) began to aggressively pursue repair services in the late 1990s. Gas turbine hot section component repair/replacement coupled with inspection/overhaul technical support has come to be known broadly as long-term service agreements (LTSAs). These agreements often extend from 6 to 18 years. The repair business ...

2009-03-17T23:59:59.000Z

142

Welding and Repair Technology Center: Underwater Laser Welding Studies  

Science Conference Proceedings (OSTI)

Repair of internal reactor components has been a continuing challenge for the nuclear industry. High radiation levels, underwater environment, and altered material weldability have made traditional repair methods more difficult to use for internal component repair. One of the key issues is to make seal-weld repairs on cracks that might exist due to stress corrosion or fatigue. Sealing of these cracks by welding might be necessary to maintain pressure boundary or flow requirements. During this research pr...

2009-12-21T23:59:59.000Z

143

HRSG Material Selection and Repair Guidelines  

Science Conference Proceedings (OSTI)

The number of failures in heat recovery steam generator (HRSG) components has been quite high during the past decade. Many of these failures are attributed to poor design, improper operation, poor fabrication, or poor installation practices. This report provides repair practices and procedures currently being used to correct a number of these problems. It also identifies domestic and international materials commonly employed.

2004-03-31T23:59:59.000Z

144

Gas exploration beyond the shelf break: An oceanographic challenge  

Science Conference Proceedings (OSTI)

Norway's second largest gas field, Ormen Lange, is located 140km west off Kristiansund at an unprecedented depth when it comes to exploration. It will be the first Norwegian project beyond the shelf break. Exploration and development of the field is ... Keywords: Currents, Offshore oil industry, Shelf break, Shelf slope, Waves

Ø. Thiem; J. Berntsen; T. Eldevik; G. Alendal

2006-02-01T23:59:59.000Z

145

Welding and Repair Technology Center: Welding and Repair Technical Issues in ASME Section XI  

Science Conference Proceedings (OSTI)

The EPRI Welding and Repair Technology Center (WRTC) supports and is involved in numerous ASME Code changes and new initiatives associated with welding, repair, and replacement activities in the nuclear power generation industry. Due to the complicated nature and numerous topics often associated with code and regulatory issues it can be difficult to keep abreast of the current status and progress of changes and new initiatives. This document is intended to be a single reference for WRTC members to ...

2012-12-20T23:59:59.000Z

146

Welding and Repair Technology Center: Welding and Repair Technical Issues in ASME Section XI  

Science Conference Proceedings (OSTI)

The Electric Power Research Institute (EPRI) Welding and Repair Technology Center (WRTC) was involved in numerous ASME Code changes and new initiatives associated with welding, repair, and replacement activities in the nuclear power generation industry during the year 2013. Due to the complicated nature of code and regulatory issues and its variety of topics, it can be difficult to keep abreast of the current status, progress, and new initiatives. This report is intended to be a single reference for ...

2013-12-16T23:59:59.000Z

147

Cells Forming Blood Vessels Send Their Copper to the Edge | Advanced Photon  

NLE Websites -- All DOE Office Websites (Extended Search)

A Molecular Cause for One Form of Deafness A Molecular Cause for One Form of Deafness Water Theory is Watertight Nanowire Micronetworks from Carbon-Black Nanoparticles A Key Step in Repairing DNA Double-Strand Breaks An X-ray Rainbow Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Cells Forming Blood Vessels Send Their Copper to the Edge FEBRUARY 20, 2007 Bookmark and Share Areas at the tips of HMVEC filopodia extensions were scanned by XFM at high resolution. The optical image is shown to the right and metal maps are shown to the left. False color images of P, Cu, and Zn are shown in the red, green and blue images respectively, and their overlay is shown to the lower right, demonstrating a transfer of cellular copper across the cell

148

Low Dose Radiation Research Program: Howard L. Liber  

NLE Websites -- All DOE Office Websites (Extended Search)

Howard L. Liber Howard L. Liber Department of Environmental and Radiological Health Sciences Colorado State University Currently Funded Projects Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells Technical Abstracts 2003 Workshop: Delayed genomic instability in human lymphoblasts exposed to 137Cs y-rays radiation Schwartz, J.L., Jordan, R., Lenarczyk, M. and Liber, H.L. 2002 Workshop: Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells. Liber, H.L. and Schwartz, J.L. Publications Zhang, Y., Zhou, J., Held, K.D., Redmond, R.W., Prise, K.M., and Liber, H.L. (2008). Deficiencies of double-strand break repair factors and effects on mutagenesis in directly [gamma]-irradiated and medium-mediated bystander human lymphoblastoid cells. Radiation Research 169(2):197-206.

149

A Molecular Cause for One Form of Deafness | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Water Theory is Watertight Water Theory is Watertight Nanowire Micronetworks from Carbon-Black Nanoparticles A Key Step in Repairing DNA Double-Strand Breaks An X-ray Rainbow An Insulating Breakthrough Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Molecular Cause for One Form of Deafness FEBRUARY 12, 2007 Bookmark and Share Gerard Wong, a professor of materials science and engineering, of physics, and of bioengineering at Illinois, and colleagues have found an underlying molecular cause for one form of deafness, while exploring the physics of hearing. (Photo by L. Brian Stauffer) Scientists exploring the physics of hearing have found an underlying molecular cause for one form of deafness, and a conceptual connection

150

10089_Primer_v1i2_spreads  

NLE Websites -- All DOE Office Websites (Extended Search)

5 Vol. 2, 5 Vol. 2, Issue 1 8 / THE PRIMER CONTACT THE PRIMER David Gilbert, Editor gilbert21@llnl.gov (925) 296-5643 New Names/Transitions Eric Abbott contract Laboratory Technician Ranjana Ambannavar contract Laboratory Technician Mariana Anaya Biomedical Scientist Shane Brubaker Computer Scientist Sandra Chaparro Career appointment Jarrod Chapman Post Doc appointment Vanessa Chiu Scientific Technician Peg Folta Acting Department Head for Informatics Navjett Kaur Laboratory Technician Victor Kunin Post Doc Konstantinos Mavrommatis Post Doc Donna McCown contract Secretary Brenda Mitchell contract Secretary Hope Tice Career appointment Jennifer White Sequencing Supervisor Matthew Zane Scientific Technician JAN 14 Stephen West, Cancer Research UK "Double-strand Break Repair in Mammalian Cells"

151

Welding and Repair Technology Center: Overlay Handbook  

Science Conference Proceedings (OSTI)

The discovery of primary water stress corrosion cracking (PWSCC) in pressurized water reactor (PWR) vessel heads and components has led to the use of corrosion-resistant high-nickel welding alloys for repair and mitigation activities. To date, more than 30 PWR units have applied weld overlays to pressurizer welds with detected indications or have applied them as a mitigation method. Although the application of weld overlays appears to be a viable solution to managing this difficult issue, the utility ind...

2012-06-29T23:59:59.000Z

152

Welding and Repair Technology Center: Overlay Handbook  

Science Conference Proceedings (OSTI)

This report reflects the commitment of the Electric Power Research Institute (EPRI) to serving its members by developing practical tools and guidance in response to specific needs of the industry.BackgroundThe discovery of primary water stress corrosion cracking (PWSCC) in pressurized water reactor (PWR) vessel heads and components has led to the use of corrosion-resistant high-nickel welding alloys for repair and mitigation activities. To date, more than 30 ...

2013-11-25T23:59:59.000Z

153

Pantex breaks ground on renewable energy project | National Nuclear  

NLE Websites -- All DOE Office Websites (Extended Search)

breaks ground on renewable energy project | National Nuclear breaks ground on renewable energy project | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > Pantex breaks ground on renewable energy project Pantex breaks ground on renewable energy project Posted By Office of Public Affairs Today was a rare windless day on the plains of the Texas Panhandle, but

154

Breaking Ground in Miami-Dade | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Breaking Ground in Miami-Dade Breaking Ground in Miami-Dade Breaking Ground in Miami-Dade October 15, 2010 - 4:28pm Addthis Existing Miami-Dade county water treatment facility. Existing Miami-Dade county water treatment facility. Andy Oare Andy Oare Former New Media Strategist, Office of Public Affairs Officials from Miami-Dade County and the U.S. Department of Energy were on hand Wednesday, October 13th to formally break ground on an innovative project that will help improve the energy efficiency of one of the county's major water treatment facilities. The project will upgrade and expand the existing power generation system at the water plant which generates electricity from digester gas produced at the plant. Landfill gas, which is produced from the Solid Waste Department's South Dade Landfill, will be collected and piped across a

155

Pantex breaks ground on renewable energy project | National Nuclear  

National Nuclear Security Administration (NNSA)

breaks ground on renewable energy project | National Nuclear breaks ground on renewable energy project | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > Pantex breaks ground on renewable energy project Pantex breaks ground on renewable energy project Posted By Office of Public Affairs Today was a rare windless day on the plains of the Texas Panhandle, but

156

Secondary Instabilities in Breaking Inertia–Gravity Waves  

Science Conference Proceedings (OSTI)

The three-dimensionalization of turbulence in the breaking of nearly vertically propagating inertia–gravity waves is investigated numerically using singular vector analysis applied to the Boussinesq equations linearized about three two-dimensional ...

Mark D. Fruman; Ulrich Achatz

2012-01-01T23:59:59.000Z

157

Observations of Wave Breaking Kinematics in Fetch-Limited Seas  

Science Conference Proceedings (OSTI)

Breaking waves play an important role in air–sea interaction, enhancing momentum flux from the atmosphere to the ocean, dissipating wave energy that is then available for turbulent mixing, injecting aerosols and sea spray into the atmosphere, and ...

Jessica M. Kleiss; W. Kendall Melville

2010-12-01T23:59:59.000Z

158

Vermont Yankee simulator qualification: large-break LOCA  

Science Conference Proceedings (OSTI)

Yankee Atomic Electric Company (YAEC) has developed simulator benchmark capabilities for the Seabrook, Maine Yankee, and Vermont Yankee Nuclear Power Station (VYNPS) simulators. The goal is to establish that each simulator has a satisfactory real-time response for different scenarios that will enhance operator training. Vermont Yankee purchased a full-scope plane simulator for the VYNPS, a four-unit boiling water reactor with a Mark-I containment. The following seven benchmark cases were selected by YAEC and VYNPC to supplement the Simulator Acceptance Test Program: (1) control rod swap; (2) partial reactor scram; (3) recirculation pump trip; (4) main steam isolation valve (MSIV) closure without scram, (5) main steamline break, (6) small-break loss-of-coolant accident (LOCA), and (7) large-break LOCA. Five simulator benchmark sessions have been completed. Each session identified simulator capabilities and limitations that needed correction. This paper discusses results from the latest large-break LOCA case.

Loomis, J.N.; Fernandez, R.T.

1987-01-01T23:59:59.000Z

159

Wave Breaking and Transition to Turbulence in Stratified Shear Flows  

Science Conference Proceedings (OSTI)

In a previous study the authors used a nonlinear, compressible, spectral collocation numerical model to examine the evolution of a breaking gravity wave in two and three dimensions. The present paper extends that effort to examine the ...

David C. Fritts; James F. Garten; Øyvind Andreassen

1996-04-01T23:59:59.000Z

160

Bubbles Produced by Breaking Waves in Fresh and Salt Waters  

Science Conference Proceedings (OSTI)

A greater volume of air is entrained by breaking waves to produce many more bubbles in salt, than in fresh, water. There are, however, little differences in their sizes. These results are consistent with reported observations of whitecaps over ...

Jin Wu

2000-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Energy Dissipation of Unsteady Wave Breaking on Currents  

Science Conference Proceedings (OSTI)

Energy dissipation for unsteady deep-water breaking in wave groups on following and opposing currents, including partial wave-blocking conditions, was investigated by detailed laboratory measurements. A range of focusing wave conditions, ...

Aifeng Yao; Chin H. Wu

2004-10-01T23:59:59.000Z

162

Microsoft Word - They Bend Before They Break.doc  

NLE Websites -- All DOE Office Websites (Extended Search)

of molecules known as aryl halides was studied, in which a halogen atom, such as chlorine or bromine, dissociates from a sizable planar ring structure, breaking its bond. The...

163

Wave Breaking Dissipation in a Young Wind Sea  

Science Conference Proceedings (OSTI)

Coupled in situ and remote sensing measurements of young, strongly-forced, wind waves are applied to assess the role of breaking in an evolving wavefield. In situ measurements of turbulent energy dissipation from wave-following “SWIFT” drifters ...

Michael Schwendeman; Jim Thomson; Johannes R. Gemmrich

164

Holographic theories of electroweak symmetry breaking without a Higgs Boson  

E-Print Network (OSTI)

Breaking without a Higgs Boson Gustavo Burdman a and1] or theories where the Higgs boson arises as a compositeto build models of a composite Higgs boson [4] and dynamical

Burdman, Gustavo; Nomura, Yasunori

2003-01-01T23:59:59.000Z

165

Moist Dynamics of Extended Monsoon Breaks over South Asia  

Science Conference Proceedings (OSTI)

In the present research to identify moist processes that initiate and maintain extended monsoon breaks over South Asia moisture and moist static energy (MSE) budgets are performed on the newly available European Centre for Medium-Range Weather ...

V. Prasanna; H. Annamalai

2012-06-01T23:59:59.000Z

166

Symmetry Breaking of H2 Dissociation by a Single Photon  

NLE Websites -- All DOE Office Websites (Extended Search)

Symmetry Breaking of H2 Symmetry Breaking of H2 Dissociation by a Single Photon Symmetry Breaking of H2 Dissociation by a Single Photon Print Wednesday, 25 July 2007 00:00 A single hydrogen (or deuterium) molecule consists of only two protons (deuterons) and two electrons and is perfectly symmetric. Linearly polarized photons are similarly symmetric. So one might think that the angular distribution of photoelectrons resulting from photoionization of the molecule by the photon accompanied by dissociation into a hydrogen atom and a hydrogen ion would itself be symmetric. However, an international team of researchers from Germany, Spain, and the U.S. has now shown that this need not be the case. When there are multiple quantum paths for the process, interference between waves in the coherent superposition of electron states (which exists when the molecular fragments are still close together) skews the distribution by breaking the molecular symmetry.

167

Air Bubbles Produced by Breaking Wind Waves: A Laboratory Study  

Science Conference Proceedings (OSTI)

Air bubbles produced by breaking wind waves are measured in a laboratory tank to study bubble clouds produced in freshwater under various wind and wave conditions. Vertical entrainment of bubbles and their size compositions are found to be ...

Paul A. Hwang; Y-H. L. Hsu; Jin Wu

1990-01-01T23:59:59.000Z

168

Distribution System Audits, Leak Detection, and Repair: Kirtland Air Force Base Leak Detection and Repair Program  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Best Management Practice Best Management Practice Case Study #3 Distribution System Audits, Leak Detection, and Repair Kirtland Air Force Base - Leak Detection and Repair Program Overview Kirtland Air Force Base (AFB) performed an award winning leak detection and repair program in 2006. The results of the project are saving Kirtland AFB 179 million gallons each year, which is over 16% of the total water use at the base. Kirtland AFB is located on 52,000 acres, southeast and adjacent to Albuquerque, New Mexico. The area is a high altitude desert, only receiving about 8 inches of rain each year. Kirtland AFB draws water from an under- ground aquifer via seven production wells through- out the base. The base also has access to water from the City of Albuquerque. The underground water

169

Distribution System Audits, Leak Detection, and Repair: Kirtland Air Force Base Leak Detection and Repair Program  

NLE Websites -- All DOE Office Websites (Extended Search)

Best Management Practice Best Management Practice Case Study #3 Distribution System Audits, Leak Detection, and Repair Kirtland Air Force Base - Leak Detection and Repair Program Overview Kirtland Air Force Base (AFB) performed an award winning leak detection and repair program in 2006. The results of the project are saving Kirtland AFB 179 million gallons each year, which is over 16% of the total water use at the base. Kirtland AFB is located on 52,000 acres, southeast and adjacent to Albuquerque, New Mexico. The area is a high altitude desert, only receiving about 8 inches of rain each year. Kirtland AFB draws water from an under- ground aquifer via seven production wells through- out the base. The base also has access to water from the City of Albuquerque. The underground water

170

Novel effects in electroweak breaking from a hidden sector  

SciTech Connect

The Higgs boson offers a unique window to hidden sector fields S{sub i}, singlets under the standard model gauge group, via the renormalizable interactions |H|{sup 2}S{sub i}{sup 2}. We prove that such interactions can provide new patterns for electroweak breaking, including radiative breaking by dimensional transmutation consistent with CERN LEP bounds, and trigger the strong enough first-order phase transition required by electroweak baryogenesis.

Espinosa, Jose Ramon [IFT-UAM/CSIC, Cantoblanco, 28049 Madrid (Spain); Quiros, Mariano [ICREA/IFAE, UAB 08193-Bellaterra Barcelona (Spain)

2007-10-01T23:59:59.000Z

171

Novel Effects in Electroweak Breaking from a Hidden Sector  

E-Print Network (OSTI)

The Higgs boson offers a unique window to hidden sector fields S_i, singlets under the Standard Model gauge group, via the renormalizable interactions |H|^2 S_i^2. We prove that such interactions can provide new patterns for electroweak breaking, including radiative breaking by dimensional transmutation consistent with LEP bounds, and trigger the strong enough first order phase transition required by electroweak baryogenesis.

Jose Ramon Espinosa; Mariano Quiros

2007-01-18T23:59:59.000Z

172

Dark Matter Stabilization Symmetries from Spontaneous Symmetry Breaking  

E-Print Network (OSTI)

We present a class of models in which the dark matter stabilization symmetry is generated by spontaneous symmetry breaking. These models naturally correlate the dark and electroweak symmetry breaking scales. The result is a generic mechanism linking the annihilation cross section for thermally populated dark matter with the weak scale. The thermal relic abundance, sensitivity to major precision electroweak observables and additional LHC signatures are also presented.

Walker, Devin G E

2009-01-01T23:59:59.000Z

173

Dark Matter Stabilization Symmetries from Spontaneous Symmetry Breaking  

E-Print Network (OSTI)

We present a class of models in which the dark matter stabilization symmetry is generated by spontaneous symmetry breaking. These models naturally correlate the dark and electroweak symmetry breaking scales. The result is a generic mechanism linking the annihilation cross section for thermally populated dark matter with the weak scale. The thermal relic abundance, sensitivity to major precision electroweak observables and additional LHC signatures are also presented.

Devin G. E. Walker

2009-07-20T23:59:59.000Z

174

Passive Acoustic Determination of Wave-Breaking Events and Their Severity across the Spectrum  

Science Conference Proceedings (OSTI)

A passive acoustic method of detecting breaking waves of different scales has been developed. The method also showed promise for measuring breaking severity.

Richard Manasseh; Alexander V. Babanin; Cameron Forbes; Kate Rickards; Irena Bobevski; Andrew Ooi

2006-04-01T23:59:59.000Z

175

Combustion Turbine Repair Guidelines: General Electric MS6001 Model B  

Science Conference Proceedings (OSTI)

For more than a decade, EPRI has been developing gas turbine hot section component repair and coating guidelines to assist utilities in the refurbishment of these critical and expensive parts. Utilities, generators, and repair vendors have used these guidelines to perform repairs on blades, turbine vanes, and combustion hardware. Guidelines now exist for a variety of conventional and advanced General Electric, Siemens/Westinghouse, Alstom, and Mitsubishi heavy frame gas turbines. The guidelines in this v...

2009-12-09T23:59:59.000Z

176

Combustion Turbine Repair Guidelines: Siemens V94.3A  

Science Conference Proceedings (OSTI)

For more than a decade, EPRI has been developing gas turbine hot section component repair and coating guidelines to assist utilities in the refurbishment of these critical and expensive parts. Utilities and repair vendors have used these guidelines to perform repairs on blades, turbine vanes, and combustion hardware. Guidelines now exist for a variety of conventional and advanced General Electric, Siemens/Westinghouse, Alstom, and Mitsubishi heavy frame gas turbines. The guidelines in this volume address...

2009-03-06T23:59:59.000Z

177

Guide for Determining Motor Repair versus Motor Replacement  

Science Conference Proceedings (OSTI)

The Motor Replacement/Refurbishment Guide (MRRG) was written to aid with the determination on whether to repair an existing motor or to purchase a replacement motor. This guideline provides the basic tools necessary to make a determination based upon, but not limited to, the extent of the repair scope and the cost of the repair. This guideline presents a process to be utilized by the station or corporate motor specialist to assess the motor repair scope both initial and revised. The data gathering proces...

2005-12-23T23:59:59.000Z

178

Lower power prices and high repair costs drive nuclear retirements ...  

U.S. Energy Information Administration (EIA)

However, concerns over the length of the review process and the high costs associated with steam generator repairs led SCE to retire both reactors.

179

Federal Facilities Maintenance, Repair Report Calls for Action  

SciTech Connect

This article is an overview of a recent report by the Federal Facilities Council on "Predicting Outcomes from Investments in Maintenance and Repair of Federal Facilities."

Bartlett, Rosemarie

2012-10-01T23:59:59.000Z

180

Classifying aging genes into DNA repair or non-DNA repair-related categories  

Science Conference Proceedings (OSTI)

The elderly population in almost every country is growing faster than ever before. However, our knowledge about the aging process is still limited despite decades of studies on this topic. In this report, we focus on the gradual accumulation of DNA damage ... Keywords: DNA-repair, aging, classification, feature selection, random forest

Yaping Fang, Xinkun Wang, Elias K. Michaelis, Jianwen Fang

2013-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Repair worlds: maintenance, repair, and ICT for development in rural Namibia  

Science Conference Proceedings (OSTI)

This paper explores the nature and centrality of maintenance and repair ('M&R') work in the extension and sustainability of ICT infrastructure in the global South. Drawing from pragmatist traditions in CSCW and the social sciences at large, we develop ... Keywords: ethnography, ictd, infrastructure, maintenance, theory

Steven J. Jackson; Alex Pompe; Gabriel Krieshok

2012-02-01T23:59:59.000Z

182

Effects of garlic on cellular doubling time and DNA strand breaks caused by UV light and BPL, enhanced with catechol and TPA  

Science Conference Proceedings (OSTI)

3T3 cell cultures were exposed to UV light and Beta-Propiolactone. Neoplastic cell transformation (TF) was demonstrated after concurrent addition of catechol, or repeated addition of TPA. Addition of garlic to all fluences/concentrations of the carcinogen/cocarcinogen/promoter groups reduced the number of transformed foci/dish by at least 40%. Since the cell cycle is prolonged following exposure to carcinogens, it is likely the cell requires a longer time to repair this damage. The doubling time (DT) was extended from 12 to 36 hrs. when cells were exposed to BPL and from 12 o 28 hrs. when cells were exposed to 3.0J/M2/sec. If an anticarcinogenic compound is also added, it is reasonable to assume that the cell cycle may be further elongated. The cell cycle, denoted by DT was lengthened from 12 to 47 hrs and from 12 to 86 hrs for BPL and UVC, respectively. The extensions occurred in a dope dependent manner. The concentrations of the cocarcinogen and promoter remained constant throughout the experiment. When strand breaks were determined at the same dose sequences, by alkaline elution, more repair was seen with garlic where the lowest and middle doses of BPL were used and almost no decrease in % DNA eluted was seen with UVC exposed cells. With catechol, there was a two-fold decrease in % DNA eluted at the lowest and middle fluences. When TPA was added, all three fluences of UVC showed more than a threefold decrease in % DNA eluted. BPS with both TPA and catechol, again showed a reduction in strand breaks only low and middle doses. Both a direct-acting alkylating agent, BPL, and a physical carcinogen, UVC, were homogeneously affected, in terms of doubling time, but not when strand break repair was examined. A separate mechanism may be responsible for repair, and the mechanism associated with combinations of physical carcinogen enhancing agents combined with some non-carcinogens may be more profoundly affected by some natural products.

Baturay, N.Z.; Gayle, F.; Liu, S.; Kreidinger, C.

1995-11-01T23:59:59.000Z

183

SB Electronics Breaks Ground on New Factory | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

SB Electronics Breaks Ground on New Factory SB Electronics Breaks Ground on New Factory SB Electronics Breaks Ground on New Factory April 29, 2010 - 5:22pm Addthis U.S. Rep. Peter Welch (from left), Vermont Lt. Gov. Brian Dubie, SBE board member Win Hunter, SBE board chair Stan Fishkin, Assi U.S. Rep. Peter Welch (from left), Vermont Lt. Gov. Brian Dubie, SBE board member Win Hunter, SBE board chair Stan Fishkin, Assi Paul Lester Communications Specialist, Office of Energy Efficiency and Renewable Energy A Vermont company broke ground on a new factory that will produce cutting-edge technology for electric and hybrid cars and create more than 100 jobs. The event ushering in SB Electronics' power ring capacitor facility in Barre was attended by Vermont Gov. Jim Douglas and federal, state and local

184

Deputy Secretary Poneman Attends Ground Breaking at Tennessee Advanced  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Attends Ground Breaking at Tennessee Attends Ground Breaking at Tennessee Advanced Vehicle Battery Plant Deputy Secretary Poneman Attends Ground Breaking at Tennessee Advanced Vehicle Battery Plant May 26, 2010 - 12:00am Addthis Smyrna, TN - Today, U.S. Deputy Secretary of Energy Daniel Poneman participated in the groundbreaking ceremony for Nissan North America's advanced battery manufacturing facility in Smyrna, Tennessee. This past January the Department closed a $1.4 billion loan with Nissan North America to retool the Smyrna factory to build advanced electric automobiles and an advanced battery manufacturing facility. "I'm excited about the future we have begun to build here today -- a future where America's workers have good jobs, making clean cars that will reduce our dependence on oil and help us transition to a clean energy economy,"

185

Symmetry Breaking of H2 Dissociation by a Single Photon  

NLE Websites -- All DOE Office Websites (Extended Search)

Symmetry Breaking of H2 Dissociation by a Single Photon Print Symmetry Breaking of H2 Dissociation by a Single Photon Print A single hydrogen (or deuterium) molecule consists of only two protons (deuterons) and two electrons and is perfectly symmetric. Linearly polarized photons are similarly symmetric. So one might think that the angular distribution of photoelectrons resulting from photoionization of the molecule by the photon accompanied by dissociation into a hydrogen atom and a hydrogen ion would itself be symmetric. However, an international team of researchers from Germany, Spain, and the U.S. has now shown that this need not be the case. When there are multiple quantum paths for the process, interference between waves in the coherent superposition of electron states (which exists when the molecular fragments are still close together) skews the distribution by breaking the molecular symmetry.

186

Symmetry Breaking of H2 Dissociation by a Single Photon  

NLE Websites -- All DOE Office Websites (Extended Search)

Symmetry Breaking of H2 Dissociation by a Single Photon Print Symmetry Breaking of H2 Dissociation by a Single Photon Print A single hydrogen (or deuterium) molecule consists of only two protons (deuterons) and two electrons and is perfectly symmetric. Linearly polarized photons are similarly symmetric. So one might think that the angular distribution of photoelectrons resulting from photoionization of the molecule by the photon accompanied by dissociation into a hydrogen atom and a hydrogen ion would itself be symmetric. However, an international team of researchers from Germany, Spain, and the U.S. has now shown that this need not be the case. When there are multiple quantum paths for the process, interference between waves in the coherent superposition of electron states (which exists when the molecular fragments are still close together) skews the distribution by breaking the molecular symmetry.

187

Deputy Secretary Poneman Attends Ground Breaking at Tennessee Advanced  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Poneman Attends Ground Breaking at Tennessee Poneman Attends Ground Breaking at Tennessee Advanced Vehicle Battery Plant Deputy Secretary Poneman Attends Ground Breaking at Tennessee Advanced Vehicle Battery Plant May 26, 2010 - 12:00am Addthis Smyrna, TN - Today, U.S. Deputy Secretary of Energy Daniel Poneman participated in the groundbreaking ceremony for Nissan North America's advanced battery manufacturing facility in Smyrna, Tennessee. This past January the Department closed a $1.4 billion loan with Nissan North America to retool the Smyrna factory to build advanced electric automobiles and an advanced battery manufacturing facility. "I'm excited about the future we have begun to build here today -- a future where America's workers have good jobs, making clean cars that will reduce our dependence on oil and help us transition to a clean energy economy,"

188

Energy Department Training Breaks New Ground | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Training Breaks New Ground Training Breaks New Ground Energy Department Training Breaks New Ground December 3, 2013 - 1:00pm Addthis The Federal Energy Management Program is now an authorized provider of continuing education units from the International Association for Continuing Education and Training. Watch the video above to learn more. Timothy Unruh FEMP Program Manager High quality education for federal government employees helps streamline operations, improve services, and ensure that taxpayer dollars are spent wisely. This is why I am pleased to announce the Energy Department's Federal Energy Management Program (FEMP) has earned the designation as an "Authorized Provider" of continuing education units (CEUs) by the prestigious International Association for Continuing Education and Training

189

NREL: News Feature - NREL Breaks Down Walls for Biofuels  

NLE Websites -- All DOE Office Websites (Extended Search)

NREL Breaks Down Walls for Biofuels NREL Breaks Down Walls for Biofuels November 30, 2009 Researchers at the National Renewable Energy Laboratory (NREL) and ethanol producers are racing to come up with ways to make ethanol from cellulosic biomass that are cheaper and easier to produce than current methods. But they are hitting a wall. Cell walls in plants are making the production of cellulosic ethanol a challenge. So researchers are creating their own computer program to help model and break down the tiny fibers of cellulose - or fibrils - found in plant cells. Although ethanol is becoming more available to consumers, NREL is working closely with the U.S. Department of Energy (DOE) to meet a quickly approaching goal to produce competitively priced ethanol for $1.50 per gallon by 2012. Why the rush? DOE believes this is the price at which

190

Ground Breaking of Blythe Solar Power Project | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Ground Breaking of Blythe Solar Power Project Ground Breaking of Blythe Solar Power Project Ground Breaking of Blythe Solar Power Project June 20, 2011 - 2:16pm Addthis Secretary Chu Secretary Chu Former Secretary of Energy What will the project do? Blythe Solar Power Project will generate 1,000 megawatts of solar power, enough to power more than 300,000 single-family homes a year. Back in April, I had the pleasure of announcing that the Department of Energy had extended our largest conditional loan guarantee for a solar project - $2.1 billion to support a concentrating solar thermal power plant near Blythe, California. Last Friday, the Blythe Solar Power Project broke ground, beginning construction of a project that upon completion will generate 1,000 megawatts of solar power, enough to power more than 300,000

191

Wind Power Reliability: Breaking Down a Barrier | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Wind Power Reliability: Breaking Down a Barrier Wind Power Reliability: Breaking Down a Barrier Wind Power Reliability: Breaking Down a Barrier June 25, 2010 - 12:16pm Addthis EnerNex Corporation is developing documentation and validating generic wind turbine and plant models that test reliability. | File photo EnerNex Corporation is developing documentation and validating generic wind turbine and plant models that test reliability. | File photo Stephen Graff Former Writer & editor for Energy Empowers, EERE The steady increase of wind power on the grid presents new challenges for power system operators charged with making sure the grid stays up and running. "We need to ensure that we are going down a path that will lead to better reliability [with wind power]," said Bob Zavadil, an executive vice

192

Breaking a Pocket of Resistance in the Fight Against Cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

Breaking a Pocket of Resistance in Breaking a Pocket of Resistance in the Fight Against Cancer Breaking a Pocket of Resistance in the Fight Against Cancer Print Thursday, 12 December 2013 11:55 ras protein The new class of inhibitors interacts with a specific mutation (Glycine to Cysteine) associated with a number of types of lung cancer. Mutations in the protein K-RAS are a very common cause for certain types of human cancers and are generally associated with a poor response to standard therapies. RAS, an abbreviation of Rat Sarcoma, is a nucleotide binding protein that responds to chemical signals (nucleotides). When in the "on" state, RAS activates other proteins, resulting in a cascade of biochemical processes; in the "off" state, RAS remains inactive. Mutations in the RAS

193

Reddit AMA: Marius Stan, energy researcher and Breaking Bad actor |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Reddit AMA: Marius Stan, energy researcher and Breaking Bad actor Reddit AMA: Marius Stan, energy researcher and Breaking Bad actor Reddit AMA: Marius Stan, energy researcher and Breaking Bad actor February 14, 2013 - 12:36pm Addthis Marius Stan, computational energy scientist from Argonne National Lab, submits his verification photo as part of an informal question and answer session with Internet users on the Ask Me Anything section of the social website Reddit. Marius Stan, computational energy scientist from Argonne National Lab, submits his verification photo as part of an informal question and answer session with Internet users on the Ask Me Anything section of the social website Reddit. Michael Hess Michael Hess Former Digital Communications Specialist, Office of Public Affairs What is an Reddit AMA? AMA stands for "Ask me anything."

194

Structural Repairs for Transmission Structures: Anchors, Poles, and Lattice Construction  

Science Conference Proceedings (OSTI)

This document provides a brief overview of repair methods for transmission line lattice and pole structures and provides guidance on the complex financial issue of how to determine whether a corrosion repair should be accounted for as capital or expense.   BackgroundAs the North American electrical transmission system ages, many issues have to be addressed to keep the system functioning. The high voltage ...

2012-12-12T23:59:59.000Z

195

The prompt emission & peculiar break of GRB 060124  

E-Print Network (OSTI)

Our multi-wavelength analysis of GRB 060124 shows the unusual behaviour of the decaying lightcurve as well as supporting the recently proposed phenomenon of long-lasting central engine activity. The prompt X-ray emission displays uncommonly well resolved flaring behaviour, with spectral evolution - indicative of central engine activity - which allows us to estimate the energy injection time for each flare. The otherwise smooth X-ray & optical afterglows demonstrate achromatic breaks at about 1 day which differ significantly from the usual jet break in the blastwave model of afterglows.

P. A. Curran; D. A. Kann; P. Ferrero; E. Rol; R. A. M. J. Wijers

2006-10-03T23:59:59.000Z

196

Dynamical SUSY Breaking and the Beta-Deformation  

E-Print Network (OSTI)

We study supersymmetry breaking metastable vacua arising from beta deformed quiver gauge theories. The relation between the bounds on metastability and the deformation are discussed. Metastable supersymmetry breaking vacua are found in the IR of beta deformed cascading quivers with vector-like field content. Furthermore the limiting case of massive Nf=Nc SQCD appears in the IR of gauge theories with chiral-like field content. We comment on the field theory origin of the deformation and on possible applications in AdS/CFT.

Amariti, A

2010-01-01T23:59:59.000Z

197

LASER ENGINEERED NET SHAPING FOR REPAIR AND HYDROGEN COMPATIBILITY  

DOE Green Energy (OSTI)

A method to repair mismatched or damaged components using Laser Engineered Net Shaping{sup R} (LENS) technology to apply material was investigated for its feasibility for components exposed to hydrogen. The mechanical properties of LENS bulk materials were also tested for hydrogen compatibility. The LENS process was used to repair simulated and actual mismachined components. These sample components were hydrogen charged and burst tested in the as-received, as-damaged, and as-repaired conditions. The testing showed that there was no apparent additional deficiency associated with hydrogen charging compared to the repair technique. The repair techniques resulted in some components meeting the requirements while others did not. Additional procedure/process development is required prior to recommending production use of LENS.

Korinko, P.; Adams, T.

2011-08-05T23:59:59.000Z

198

Development of a composite repair system for reinforcing offshore risers  

E-Print Network (OSTI)

A research program was conducted to investigate the application of composite materials in repairing corroded offshore risers, leading to the development of an optimized repair using a hybrid carbon/E-glass system. The objective of this research program was to investigate the feasibility of extending onshore composite repair techniques to offshore risers by developing integrated analytical and experimental methods. The study considered loads typical for offshore risers including internal pressure, tension, and bending. To fulfill this objective efforts included a state of the art assessment of current composite repair technology, designing a carbon-based composite repair system optimized by numerical simulation with prototype testing, and providing guidelines for industry in repairing and reinforcing offshore risers using composite materials. Research efforts integrated numerical modeling, as well as full-scale testing that included four composite repair manufacturers to assess the current state of the art on pipe samples with simulated corrosion reinforced with composite materials. Analysis and testing were also performed on the optimized carbon/E-glass system. The results of this program demonstrated that composite materials are a viable means for repairing corroded offshore steel risers as adequate reinforcement ensures that the steel risers are not loaded beyond acceptable design limits. For corroded risers, the results demonstrated through analysis and full-scale testing efforts that properly designed composite repair systems can provide adequate structural reinforcement to ensure that excessive strains are not induced in the steel when subjected to internal pressure, axial tension, and bending design loads. This was verified experimentally using strain gages placed beneath the composite repair. This program is the first of its kind and is thought to contribute significantly to the future of offshore riser repairs. It is likely that the findings of this program will foster future investigations involving operators by integrating their insights regarding the need for composite repair based on emerging technology. One of the most significant contributions to the existing body of work is the use of limit analysis in developing design limits for the repair of steel pipes using composite materials.

Alexander, Christopher Richard

2007-12-01T23:59:59.000Z

199

Measurements of Temperature Fluctuations in Breaking Surface Waves  

Science Conference Proceedings (OSTI)

Measurements of temperature fluctuations and air entrainment within the upper 1 m of the surface caused by breaking surface waves have been acquired with a novel surface-following sensor array. Brief temperature fluctuations of order 20 mK–100 mK ...

David M. Farmer; Johannes R. Gemmrich

1996-05-01T23:59:59.000Z

200

Gas exploration and oceanography beyond the shelf break  

E-Print Network (OSTI)

Gas exploration and oceanography beyond the shelf break Ã?. Thiem1 , J. Berntsen1,2 , G. Alendal2 cause problems for installations needed for exploration of the gas field. Bergen Ocean Model (BOM) has for Computational Science, University of Bergen, Norway 3 Norsk Hydro, Oil & Energy, Research Center, Bergen, Norway

Thiem, Ã?yvind

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Gas exploration beyond the shelf break: An oceanographic challenge  

E-Print Network (OSTI)

Gas exploration beyond the shelf break: An oceanographic challenge Ã?. Thiema, *, J. Berntsena,b , T industries point of view, this research has been of limited interest since the oil and gas fields have been, 5059 Bergen, Norway Available online 24 December 2004 Abstract Norway's second largest gas field, Ormen

Thiem, Ã?yvind

202

The far-UV break in quasar energy distributions: dust?  

E-Print Network (OSTI)

A prominent continuum steepening is observed in quasar energy distributions near 1100A. We review possible interpretations for the origin of the so-called far-UV break, putting emphasis on those that favor the emergence of an upturn in the extreme-UV.

L. Binette; Y. Krongold; S. Haro-Corzo; A. Andersen

2006-11-01T23:59:59.000Z

203

Spectral Energy Balance of Breaking Waves within the Surf Zone  

Science Conference Proceedings (OSTI)

The spectral energy balance of ocean surface waves breaking on a natural beach is examined with field observations from a cross-shore array of pressure sensors deployed between the shoreline and the outer edge of the surf zone near Duck, North ...

T. H. C. Herbers; N. R. Russnogle; Steve Elgar

2000-11-01T23:59:59.000Z

204

Small break LOCA analysis for Maanshan nuclear power plant  

SciTech Connect

Since 1990, Taiwan Power Company has conducted a LWR LOCA technology transfer program on RELAP5YA computer code from Yankee Atomic Electric Company (YAEC). One objective of this program is to acquire the RELAP5YA computer code from YAEC for Taipower in-house licensing analysis. The RELAP5YA is a computer program developed at YAEC for analysing the dynamic behaviour of thermal-hydraulic systems, and it can cover most of the postulated accidents and transients in light water reactor systems. In this paper, Taipower`s engineers have performed a small break loss of coolant accidents analysis for Maanshan nuclear power plant. Thais action is used to perform the licensing actions for increasing the operation margin on the steam generator tube plugging. The result is shown that the steam generator tube can be plugged slightly without a reduction in safety margins. This analysis covers a spectrum of break size for a small break LOCA. For a complete spectrum of the transient and accident analysis, the large break LOCA and the non-LOCA analysis were performed by the fuel vendor for the reload safety evaluation.

Jer-Cherng Kang; Shou-Chuan Chiang; Lang-Chen Wang [Taiwan Power Company, Taipei (China)

1994-12-31T23:59:59.000Z

205

Wave Breaking Dissipation in the Wave-Driven Ocean Circulation  

Science Conference Proceedings (OSTI)

If wave breaking modifies the Lagrangian fluid paths by inducing an uncertainty in the orbit itself and this uncertainty on wave motion time scales is observable as additive noise, it is shown that within the context of a wave–current interaction ...

Juan M. Restrepo

2007-07-01T23:59:59.000Z

206

Aeration Due to Breaking Waves. Part I: Bubble Populations  

Science Conference Proceedings (OSTI)

The population of bubbles produced by breaking waves in (10 m) winds of up to 12 m s?1 is analyzed using calibrated images from a vertical pencil-beam sonar system placed on the seabed near the Dutch coast. The structure in the images is ...

A. Graham; D. K. Woolf; A. J. Hall

2004-05-01T23:59:59.000Z

207

Near-Surface Turbulence in the Presence of Breaking Waves  

Science Conference Proceedings (OSTI)

Observations with a three-axis pulse-to-pulse coherent acoustic Doppler profiler and acoustic resonators reveal the turbulence and bubble field beneath breaking waves in the open ocean at wind speeds up to 14 m s?1. About 55%–80% of velocity ...

Johannes R. Gemmrich; David M. Farmer

2004-05-01T23:59:59.000Z

208

The Link between Rossby Wave Breakings and Weather Regime Transitions  

Science Conference Proceedings (OSTI)

The link between Rossby wave breaking (RWB) and the four wintertime weather regimes over the North Atlantic domain is studied in this paper. Using the 40-yr ECMWF Re-Analysis (ERA-40) data, frequencies of occurrence of anticyclonic and cyclonic ...

Clio Michel; Gwendal Rivière

2011-08-01T23:59:59.000Z

209

Gravity Wave Breaking in Two-Layer Hydrostatic Flow  

Science Conference Proceedings (OSTI)

To better understand mountain-induced gravity wave breaking and potential vorticity generation in the troposphere, a two-layer hydrostatic flow over a three-dimensional Witch-of-Agnesi type of mountain is investigated. It is suggested that a two-...

Qingfang Jiang; Ronald B. Smith

2003-05-01T23:59:59.000Z

210

Guidelines for the Repair of Nuclear Power Plant Safety-Related Motors (NCIG-12)  

Science Conference Proceedings (OSTI)

These guidelines, the twelfth in a series cosponsored by NCIG, provide utilities with information on the repair of all classes of safety-related electric motors. Use of this information will permit capable repair shops to repair motors under the extension of utility quality assurance programs or by dedication of a commercially repaired motor.

1990-04-24T23:59:59.000Z

211

Solar Water Heating System Maintenance and Repair | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Water Heating System Maintenance and Repair Water Heating System Maintenance and Repair Solar Water Heating System Maintenance and Repair May 30, 2012 - 2:35pm Addthis Rooftop solar water heaters need regular maintenance to operate at peak efficiency. | Photo from iStockphoto.com Rooftop solar water heaters need regular maintenance to operate at peak efficiency. | Photo from iStockphoto.com Solar energy systems require periodic inspections and routine maintenance to keep them operating efficiently. Also, from time to time, components may need repair or replacement. You should also take steps to prevent scaling, corrosion, and freezing. You might be able to handle some of the inspections and maintenance tasks on your own, but others may require a qualified technician. Ask for a cost estimate in writing before having any work done. For some systems, it may

212

Optimizing chondrogenic factors and protein delivery methods for cartilage repair  

E-Print Network (OSTI)

Joint injuries are common and often result in damage to cartilage, which has a limited ability to repair itself. Tissue engineering is a promising approach for improving cartilage healing in which biomaterials and chemical ...

Florine, Emily Marie

2012-01-01T23:59:59.000Z

213

Competing risks for repairable systems: A data study  

E-Print Network (OSTI)

". The maintainable items making up the compressor unit are, among others, valves, internal piping and radial bearing by the corresponding repair. We will therefore follow the OREDA Handbook and make our analysis at the subunit level

Langseth, Helge

214

Checkpoint repair for out-of-order execution machines  

Science Conference Proceedings (OSTI)

Out-of-order execution and branch prediction are two mechanisms that can be used profitably in the design of Supercomputers to increase performance. Unfortunately this means there must be some kind of repair mechanism, since situations do occur that ...

W. W. Hwu; Y. N. Patt

1987-06-01T23:59:59.000Z

215

Gas Turbine Compressor Field Repair Guideline: GE 7FA  

Science Conference Proceedings (OSTI)

This guideline is designed to assist gas turbine owners confronted with limited damage to compressor rotating blade airfoils. The guideline addresses typical damage to the airfoil tip and leading edge where a limited amount of material trimming and blending is allowable. The guideline provides an engineering basis for implementing safe repairs and avoiding possible risk of airfoil failure due to high-cycle fatigue. In-situ field repair criteria are given for each compressor row R-0 through R-17 for ...

2012-12-03T23:59:59.000Z

216

On site ESP repair pays off in Indonesia  

Science Conference Proceedings (OSTI)

This paper discusses how extensive production and use of electric submersible pumps (ESPs) in a remote region of Southeast Asia prompted an oil company to establish its own ESP repair facility. The facility has met three defined objectives, and the scope of its work has been expanded. However, several elements must be present before such a remote operation can be successful. This repair facility is at the Kasim Marine Terminal in Irian Jaya.

Haines, J.D. (Southeast Asia Corp., Applied Technics, Skiatook, OK (US)); Langnes, G.L. (Dragon Pacific Offshore Services PTE, Ltd. (SG)); Hadipoetro, H. (Petromer Trend Corp., Kasmim Marine Terminal, Irian Jaya (ID))

1990-09-10T23:59:59.000Z

217

Geothermal Well Maintenance and Repair in Cerro Prieto  

DOE Green Energy (OSTI)

When the first well is drilled at a geothermal field, procedures for the cleaning, repair, and control of wells should be established. This aspect will be increasingly important as more wells are drilled. Equipment, tools and techniques need to be improved to achieve economic and safe results. Different systems have been developed and applied in maintenance of wells, in problems of casing incrustations, repairs, plugging, and well control. These systems should be improved, even though they have been reasonably satisfactory to date.

Aguirre, B. D.; Blanco, F. V.

1981-01-01T23:59:59.000Z

218

Steam Turbine Casing and Valve Body Repair Guidelines  

Science Conference Proceedings (OSTI)

Today’s flexible mode of operation can result in damage to heavy-section components, such as steam turbine and valve casings. Thus, owners and operators are often faced with repairing a critical component. This report is part of a set of documents that address the key areas in the asset management of steam turbine casings and valve bodies—nondestructive evaluation and damage detection, repair, and life ...

2013-12-14T23:59:59.000Z

219

Are vortices in rotating superfluids breaking the Weak Equivalence Principle?  

E-Print Network (OSTI)

Due to the breaking of gauge symmetry in rotating superfluid Helium, the inertial mass of a vortex diverges with the vortex size. The vortex inertial mass is thus much higher than the classical inertial mass of the vortex core. An equal increase of the vortex gravitational mass is questioned. The possibility that the vortices in a rotating superfluid could break the weak equivalence principle in relation with a variable speed of light in the superfluid vacuum is debated. Experiments to test this possibility are investigated on the bases that superfluid Helium vortices would not fall, under the single influence of a uniform gravitational field, at the same rate as the rest of the superfluid Helium mass.

Clovis Jacinto de Matos

2009-09-15T23:59:59.000Z

220

Acceleration of the cosmic expansion induced by symmetry breaking  

E-Print Network (OSTI)

It is proved that in order to obtain a model of the accelerated cosmic expansion the thing one only need to do is to add a perturbation term to the Einstein-Hilbert Lagrangian. This term leads to some symmetry breaking terms in the fields equation, which makes the cosmic expansion accelerating. A vacuum de Sitter solution is obtained. A new explanation of the acceleration of the cosmic expansion is presented. In this model the changing of the expansion from decelerating to accelerating is an intrinsic property of the universe without need of an exotic dark energy. The acceleration of the cosmic expansion is induced by the symmetry breaking perturbation of the gravitational energy. The cosmological constant problem, the coincidence problem and the problem of phantom divide line crossing are naturally solved. The results of the model are roughly consistent with the observations.

G. Y. Chee

2013-01-21T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

DOE Joint Genome Institute: Breaking down cellulose without blasting  

NLE Websites -- All DOE Office Websites (Extended Search)

4, 2011 4, 2011 Breaking down cellulose without blasting lignin: "Dry rot" genome offers lessons for biofuel pretreatment WALNUT CREEK, Calif.-Feared by realtors and homeowners alike, dry rot due to the fungus Serpula lacrymans causes millions of dollars worth of damage to homes and buildings around the world. This brown rot fungus' capacity to break down the cellulose in wood led to its selection for sequencing by the U.S. Department of Energy (DOE) Joint Genome Institute (JGI) in 2007, with the goal of identifying the enzymes involved in the degradation process and using the information to improve cellulosic biofuels production. Photo: A variant of Serpula lacrymans causes dry rot. (Dave Brown via Flickr/Creative Commons Attribution 2.0) As reported online July 14 in Science Express, an international team of

222

Breaks in the Asian Monsoon: The Influence of Southern Hemisphere Weather Systems  

Science Conference Proceedings (OSTI)

Atmospheric model results suggest that chaotic weather systems in the Southern Hemisphere midlatitudes can trigger “breaks” in the Indian monsoon rainfall. Indeed, the mechanism may be able to trigger a more general break of the entire Asian ...

Mark J. Rodwell

1997-11-01T23:59:59.000Z

223

Spectral Distribution of Energy Dissipation of Wind-Generated Waves due to Dominant Wave Breaking  

Science Conference Proceedings (OSTI)

This paper considers an experimental attempt to estimate the spectral distribution of the dissipation due to breaking of dominant waves. A field wave record with an approximately 50% dominant-breaking rate was analyzed. Segments of the record, ...

Ian R. Young; Alexander V. Babanin

2006-03-01T23:59:59.000Z

224

Bubbles Help Break Energy Storage Record for Lithium Air-Batteries  

NLE Websites -- All DOE Office Websites (Extended Search)

Bubbles Help Break Energy Storage Record for Lithium Air-Batteries Bubbles Help Break Energy Storage Record for Lithium Air-Batteries Foam-base graphene keeps oxygen flowing in...

225

Modulational Instabilities and Breaking Strength for Deep-Water Wave Groups  

Science Conference Proceedings (OSTI)

Progression of nonlinear wave groups to breaking was studied numerically and experimentally. Evolution of such wave group parameters as a function of distance to breaking and modulation depth—the height ratio of the highest and the lowest waves ...

Alina Galchenko; Alexander V. Babanin; Dmitry Chalikov; I. R. Young; Tai-Wen Hsu

2010-10-01T23:59:59.000Z

226

Three dimensional effects in analysis of PWR steam line break accident  

E-Print Network (OSTI)

A steam line break accident is one of the possible severe abnormal transients in a pressurized water reactor. It is required to present an analysis of a steam line break accident in the Final Safety Analysis Report (FSAR) ...

Tsai, Chon-Kwo

227

Experimental Investigation of Wave Breaking Criteria Based on Wave Phase Speeds  

Science Conference Proceedings (OSTI)

Experiments were performed that test the kinematic breaking criterion, which states that the horizontal fluid particle velocity at the surface of a crest exceeds the local phase speed of the crest prior to breaking. Three different definitions of ...

Paul Stansell; Colin MacFarlane

2002-05-01T23:59:59.000Z

228

Experimental investigation of small-scale breaking waves : flow visualization across the air-water interface  

E-Print Network (OSTI)

The dynamics of breaking waves significantly affect air-sea fluxes of heat, momentum, mass and energy across the ocean interface. Breaking waves also contribute considerable loading to offshore and coastal structures, and ...

McDonald, Angus Kai

2005-01-01T23:59:59.000Z

229

Modeling the Propagation, Breaking and Drift of Ocean Surface Wave  

E-Print Network (OSTI)

A new model other than the classical ones given by Airy, Stokes and Gerstner for the ocean surface wave is constructed. It leads to new understandings for the wave mechanisms: (1) A wave with bigger amplitude or smaller steepness travels faster; (2) The wave breaks when the front angle is bigger than 46.3 degree; (3) The magnitude of the wave drift should be smaller than that of the known Stokes drift.

Jin-Liang Wang

2013-04-03T23:59:59.000Z

230

Electroweak and supersymmetry breaking from the Higgs discovery  

E-Print Network (OSTI)

We will explore the consequences on the electroweak breaking condition, the mass of supersymmetric partners and the scale at which supersymmetry is broken, for arbitrary values of the supersymmetric parameters tan(beta) and the stop mixing X_t, which follow from the Higgs discovery with a mass m_H\\simeq 126 GeV at the LHC. Within the present uncertainty on the top quark mass we deduce that radiative breaking requires tan(beta) \\gtrsim 7 for maximal mixing X_t\\simeq \\sqrt{6}, and tan(beta) \\gtrsim 20 for small mixing X_t\\lesssim 1. The scale at which supersymmetry is broken \\mathcal M can be of order the unification or Planck scale only for large values of tan(beta) and negligible mixing X_t\\simeq 0. On the other hand for maximal mixing and large values of tan(beta) supersymmetry should break at scales as low as \\mathcal M\\simeq 10^5 GeV. The uncertainty in those predictions stemming from the uncertainty in the top quark mass, i.e. the top Yukawa coupling, is small (large) for large (small) values of tan(beta). In fact for tan(beta)=1 the uncertainty on the value of \\mathcal M is of several orders of magnitude.

Antonio Delgado; Mateo Garcia; Mariano Quiros

2013-12-11T23:59:59.000Z

231

Biochemical characterization of the E. coli Very Short Patch Repair pathway and its coordination with methyltransferase repair of 0?-methylguanine  

E-Print Network (OSTI)

The E. coli Very Short Patch Repair (VSPR) system corrects T:G mismatches that arise through Dcm-mediated methylation and subsequent deamination of the underlined cytosine residue in the palindromic sequence 5'-CCWGG-3' ...

Rye, Peter Thomas

2006-01-01T23:59:59.000Z

232

Dynamics of Wave Breaking at a Coastal Sea Wall  

E-Print Network (OSTI)

Structural designs barely consider the dynamic scenario of a well-developed impinging wave hitting the structure. The usual area of focus is on static and stability factors (e.g. drag, inertia, resistive forces related to weight, buoyancy, sliding etc). Even the "Factor of Safety" which is regularly used in designs to account for unknown and/or unforeseen situations which might occur implies a degree of uncertainty about the dynamic scenario of breaking waves in the coastal environment. In the present study the hydrodynamics of a coastal structure-turbulent bore interaction was studied by examination (two-dimensional) of the singular case of a plunging breaking wave forming a well developed turbulent bore which impacted on a model sea wall structure. The turbulent bore impact event was found to display similar characteristics to the impact event of other wave shapes, in particular that of a plunging breaker. Examination of the impact event confirmed the conversion of nearly all horizontal velocity to vertical velocity during the "flip through" event. In accordance with theoretical expectations the location of maximum pressure was found to occur just below the still water level (SWL). Resulting pressure data in the present study consisted of two blunt spikes as opposed to the "church-roof" (high spike) shape seen in other results. The shape of the pressure data was attributed to the following: firstly, to the initial impact of the protruding jet of the breaking wave which causes the first maxima, secondly, to the sensor encountering the bulk of the entrapped air hence causing the drop in pressure between the blunt spikes and lastly, to the inherent hydrostatic pressure combined with the compression of the entrapped air bubbles, by the subsequent forward motion of the water within the wave, which causes the second maxima. The point of maximum pressure was found to always be within the second maxima. Observation of the turbulent bore-structure interaction showed that the consequential maximum pressure was a direct result of the compression of entrapped air by the weight of the water in the wave as it continued forward onto the structure combined with the inherent hydrostatic pressure of the wave. The project was conducted in an attempt to contribute to the vast knowledge of coastal structure-wave interactions and to add to the understanding of the physics and characteristics of breaking waves. Whilst numerous studies and experiments have been carried out on the phenomenon of breaking waves by previous researchers the current project highlights the advent of new equipment and technological advances in existing methods.

Antoine, Arthur L.

2009-12-01T23:59:59.000Z

233

A Newly Discovered DNA Repair Mechanism | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

scanning for these lesions. When they encounter one, they break the base pair bond and flip the deformed base out of the DNA double helix. The enzyme contains a specially shaped...

234

Recombinant methods for screening human DNA excision repair proficiency  

SciTech Connect

A method for measuring DNA excision repair in response to ultraviolet radiation (UV)-induced DNA damage has been developed, validated, and field-tested in cultured human lymphocytes. The methodology is amenable to population-based screening and should facilitate future epidemiologic studies seeking to investigate associations between excision repair proficiency and cancer susceptibility. The impetus for such endeavors derives from the belief that the high incidence of skin cancer in the genetic disorder xeroderma pigmentosum (XP) primarily is a result of the reduced capacity of patients cells to repair UV-induced DNA damage. For assay, UV-irradiated non-replicating recombinant plasmid DNA harboring a chloramphenicol acetyltransferase (CAT) indicator gene is introduced into lymphocytes using DEAE-dextran short-term transfection conditions. Exposure to UV induces transcriptionally-inactivating DNA photoproducts in the plasmid DNA which inactivate CAT gene expression. Excision repair of the damaged CAT gene is monitored indirectly as a function of reactivated CAT enzyme activity following a 40 hour repair/expression incubation period.

Athas, W.F.

1988-01-01T23:59:59.000Z

235

Polymer nanocomposites for high-temperature composite repair  

SciTech Connect

A novel repair agent for resin-injection repair of advanced high temperature composites was developed and characterized. The repair agent was based on bisphenol E cyanate ester (BECy) and reinforced with alumina nanoparticles. To ensure good dispersion and compatibility with the BECy matrix in nanocomposites, the alumina nanoparticles were functionalized with silanes. The BECy nanocomposites, containing bare and functionalized alumina nanoparticles, were prepared and evaluated for their thermal, mechanical, rheological, and viscoelastic properties. The monomer of BECy has an extremely low viscosity at ambient temperature, which is good for processability. The cured BECy polymer is a highly cross-linked network with excellent thermal mechanical properties, with a high glass transition temperature (T{sub g}) of 270 C and decomposition temperature above 350 C. The incorporation of alumina nanoparticles enhances the mechanical and rheological properties of the BECy nanocomposites. Additionally, the alumina nanoparticles are shown to catalyze the cure of BECy. Characterization of the nanocomposites included dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy. The experimental results show that the BECy nanocomposite is a good candidate as repair agent for resin-injection repair applications.

Sheng, Xia

2008-12-01T23:59:59.000Z

236

Phenomenological issues in supersymmetry with nonholomorphic soft breaking  

SciTech Connect

We present a through discussion of motivations for and phenomenological issues in supersymmetric models with minimal matter content and nonholomorphic soft-breaking terms. Using the unification of the gauge couplings and assuming SUSY is broken with nonstandard soft terms, we provide semianalytic solutions of the RGEs for low and high choices of tan{beta} which can be used to study the phenomenology in detail. We also present a generic form of RGIs in mSUGRA framework which can be used to derive new relations in addition to those existing in the literature. Our results are mostly presented with respect to the conventional minimal supersymmetric model for ease of comparison.

Cakir, M.A.; Mutlu, S.; Solmaz, L. [Department of Physics, Izmir Institute of Technology, IZTECH, TR35430 (Turkey); Department of Physics, Balikesir University, Balikesir, TR10100 (Turkey)

2005-06-01T23:59:59.000Z

237

Chiral symmetry breaking revisited: the gap equation with lattice ingredients  

Science Conference Proceedings (OSTI)

We study chiral symmetry breaking in QCD, using as ingredients in the quark gap equation recent lattice results for the gluon and ghost propagators. The Ansatz employed for the quark-gluon vertex is purely non-Abelian, introducing a crucial dependence on the ghost dressing function and the quark-ghost scattering amplitude. The numerical impact of these quantities is considerable: the need to invoke confinement explicitly is avoided, and the dynamical quark masses generated are of the order of 300 MeV. In addition, the pion decay constant and the quark condensate are computed, and are found to be in good agreement with phenomenology.

Aguilar, Arlene C. [Federal University of ABC, CCNH, Rua Santa Adelia 166, CEP 09210-170, Santo Andre (Brazil)

2011-05-23T23:59:59.000Z

238

Constraint on the (GUT) symmetry breaking scale and topological defects  

Science Conference Proceedings (OSTI)

In F-term supergravity inflation models, scalar fields other than the inflaton generically receive a Hubble induced mass, which may restore gauge symmetries during inflation and phase transitions may occur during or after inflation as the Hubble parameter decreases. We study topological defect formation associated with such a phase transition in chaotic inflation in supergravity and obtain a severe constraint on the symmetry breaking scale which is related with the tensor-to-scalar ratio. This talk is based on the paper [1].

Kamada, Kohei; Nakayama, Kazunori; Yokoyama, Jun'ichi [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Department of Physics, Graduate School of Science, University of Tokyo, Tokyo 113-0033 (Japan); Research Center for the Early Universe (RESCEU), Graduate School of Science, University of Tokyo, Tokyo 113-0033 (Japan) and Kavli institute for the Physics and Mathematics of the Universe (IPMU), University of Tokyo, Kashiwa, Chiba, 277-8568 (Japan)

2012-07-27T23:59:59.000Z

239

Protein Bridges DNA Base and Nucleotide Excision Repair Pathways  

NLE Websites -- All DOE Office Websites (Extended Search)

Protein Bridges DNA Base and Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Wednesday, 28 October 2009 00:00 Alkyltransferase proteins (AGT) protect cells from the biological effects of DNA damage caused by the addition of alkyl groups (alkylation). Alkyltransferase-like proteins (ATLs) can do the same, but they lack the reactive cysteine residue that allows the alkyltransferase function, and the mechanism for cell protection has remained unknown. To address this mystery, a British-American team lead by researchers at the Scripps Research Institute recently applied a combination of x-ray structural, biochemical, and genetic studies to ATLs in the yeast Schizosaccharomyces pombe without and with damaged DNA. By showing how a process called non-enzymatic nucleotide flipping activates ATL-initiated DNA repair, their results may improve our understanding of genomic integrity and responses to DNA damage relevant to pathogens and cancer development.

240

Protein Bridges DNA Base and Nucleotide Excision Repair Pathways  

NLE Websites -- All DOE Office Websites (Extended Search)

Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Alkyltransferase proteins (AGT) protect cells from the biological effects of DNA damage caused by the addition of alkyl groups (alkylation). Alkyltransferase-like proteins (ATLs) can do the same, but they lack the reactive cysteine residue that allows the alkyltransferase function, and the mechanism for cell protection has remained unknown. To address this mystery, a British-American team lead by researchers at the Scripps Research Institute recently applied a combination of x-ray structural, biochemical, and genetic studies to ATLs in the yeast Schizosaccharomyces pombe without and with damaged DNA. By showing how a process called non-enzymatic nucleotide flipping activates ATL-initiated DNA repair, their results may improve our understanding of genomic integrity and responses to DNA damage relevant to pathogens and cancer development.

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

RECORD OF CATEGORICAL EXCLUSION DETERMINATION Hygiene Substation Access Road Repairs  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Hygiene Substation Access Road Repairs Hygiene Substation Access Road Repairs A. Brief Description of Proposal: Western Area Power Administration proposes to repair the access road/driveway into the Hygiene Substation. There is a low spot in the middle of the driveway that impedes maneuvering oflarge maintenance equipment in and out of the yard. Western plans to fill the low spot with road base and crumbled concrete fill. The Hygiene Substation is located in Boulder County, approximately 2 miles northwest of Longmont, CO (T3N, R69W, Sec 18). All proposed construction will occur within the existing, disturbed substation access road/driveway. B. Number and Title of tile Categorical Exclusion Being Applied: (See text in 10 CFR 1021, Subpart D.) BI.3 Routine maintenance activities and custodial services for buildings, structures,

242

Protein Bridges DNA Base and Nucleotide Excision Repair Pathways  

NLE Websites -- All DOE Office Websites (Extended Search)

Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Alkyltransferase proteins (AGT) protect cells from the biological effects of DNA damage caused by the addition of alkyl groups (alkylation). Alkyltransferase-like proteins (ATLs) can do the same, but they lack the reactive cysteine residue that allows the alkyltransferase function, and the mechanism for cell protection has remained unknown. To address this mystery, a British-American team lead by researchers at the Scripps Research Institute recently applied a combination of x-ray structural, biochemical, and genetic studies to ATLs in the yeast Schizosaccharomyces pombe without and with damaged DNA. By showing how a process called non-enzymatic nucleotide flipping activates ATL-initiated DNA repair, their results may improve our understanding of genomic integrity and responses to DNA damage relevant to pathogens and cancer development.

243

Protein Bridges DNA Base and Nucleotide Excision Repair Pathways  

NLE Websites -- All DOE Office Websites (Extended Search)

Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Alkyltransferase proteins (AGT) protect cells from the biological effects of DNA damage caused by the addition of alkyl groups (alkylation). Alkyltransferase-like proteins (ATLs) can do the same, but they lack the reactive cysteine residue that allows the alkyltransferase function, and the mechanism for cell protection has remained unknown. To address this mystery, a British-American team lead by researchers at the Scripps Research Institute recently applied a combination of x-ray structural, biochemical, and genetic studies to ATLs in the yeast Schizosaccharomyces pombe without and with damaged DNA. By showing how a process called non-enzymatic nucleotide flipping activates ATL-initiated DNA repair, their results may improve our understanding of genomic integrity and responses to DNA damage relevant to pathogens and cancer development.

244

Simple Maintenance Saves Costly Furnace Repair/Replacement | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Simple Maintenance Saves Costly Furnace Repair/Replacement Simple Maintenance Saves Costly Furnace Repair/Replacement Simple Maintenance Saves Costly Furnace Repair/Replacement January 6, 2010 - 8:26am Addthis Chris Stewart Senior Communicator at DOE's National Renewable Energy Laboratory For the past few weeks, my forced-air gas furnace has been on the fritz. I blame this on the fact that I haven't been as diligent as I should have been with regular furnace maintenance, which includes: Checking the condition of the vent connection pipe and chimney Checking the physical integrity of the heat exchanger Adjusting the controls to provide optimum water and air temperature settings for both efficiency and comfort Having a technician perform a combustion-efficiency test Checking the combustion chamber for cracks. Testing for carbon monoxide

245

Intrinsic transverse momentum and dynamical chiral symmetry breaking  

Science Conference Proceedings (OSTI)

We study the effect of QCD vacuum structure on the intrinsic transverse momentum distribution of partons in the nucleon at a low scale. The dynamical breaking of chiral symmetry is caused by non-perturbative interactions at distances of the order rho ~ 0.2 - 0.3 fm, much smaller than the typical nucleon size R ~ 1 fm, resulting in a two-scale picture of nucleon structure. Using an effective dynamical model based on chiral constituent quark degrees of freedom and the 1/N_c expansion (chiral quark-soliton model), we calculate the transverse momentum distribution of quarks and antiquarks at a low scale. The distribution of valence quarks is localized at p_T ~ 1/R. The distribution of flavor-singlet unpolarized sea quarks exhibits a power-like tail extending up to the chiral-symmetry-breaking scale 1/{rho}. A similar tail is present in the flavor-nonsinglet polarized sea. These features are model-independent and represent the imprint of the QCD vacuum on the nucleon's partonic structure. At the level of the nucleon's light-cone wave function, we show that sea quarks partly exist in correlated pairs of transverse size {rho} << R, analogous to short-range NN correlations in nuclei. We discuss the implications of our findings for the transverse momentum distributions in hard scattering processes (semi-inclusive DIS, Drell-Yan pair production) and possible experimental tests of the non-perturbative parton correlations induced by QCD vacuum structure.

Christian Weiss, Peter Schweitzer, Mark Strikman

2013-01-01T23:59:59.000Z

246

Intermediate-break LOCA analyses for the AP600 design  

Science Conference Proceedings (OSTI)

A postulated double-ended guillotine break of a direct-vessel-injection line in an AP600 plant has been analyzed. This event is characterized as an intermediate break loss-of-coolant accident (IBLOCA). Most of the insights regarding the response of the AP600 safety systems to the postulated accident are derived from calculations performed with the TRAC-PFl/MOD2 code. However, complementary insights derived from a scaled experiment conducted in the ROSA facility, as well as insights based upon calculations by other codes, are also presented. The key processes occurring in an AP600 during a IBLOCA are primary coolant system depressurization, inventory depletion, inventory replacement via emergency core coolant injection, continuous core cooling, and long-term decay heat rejection to the atmosphere. Based upon the calculated and experimental results, the AP600 will not experience a core heat up and will reach a safe shutdown state using only safety-class equipment. Only the early part of the long-term cooling period initiated by In-containment Refueling Water Storage Tank injection was evaluated Thus, the observation that the core is continuously cooled should be verified for the latter phase of the long-term cooling period, the interval when sump injection and containment cooling processes are important.

Boyack, B.E.; Lime, J.F.

1995-07-01T23:59:59.000Z

247

Welding and Repair Technology Center: Alternative Rules for Temperbead Qualification  

Science Conference Proceedings (OSTI)

Temperbead welding is common practice in the nuclear power industry for in situ repair of quenched and tempered low-alloy steels when post-weld heat treatment is impractical. The temperbead process controls the heat input so that the weld heat-affected zone in the low-alloy steel is tempered by the welding heat of subsequent layers. The tempering achieved in this way eliminates the need for post-weld heat treatment. Unfortunately, repair organizations in the nuclear power industry are ...

2012-09-28T23:59:59.000Z

248

Loss of ATM Function Enhances Recombinant Adeno-Associated Virus Transduction and Integration through Pathways Similar to UV Irradiation  

E-Print Network (OSTI)

as double-stranded breaks occurs frequently on exposure to chemical carcinogens and radiation *Departments of Anatomy and Cell Biology and of Internal Medicine, Center for Gene Therapy, and Department and ionizing radiation ap- pears to be altered in AT patients, because the onset of p53 activation is delayed

Engelhardt, John F.

249

An engineering analysis of natural and biomimetic self-repair processes for solar energy harvesting  

E-Print Network (OSTI)

Plants have evolved highly sophisticated mechanisms of self-repair to regenerate proteins that become photo-damaged over time. Key to this self-repair process is the reversible self-assembly of protein complexes, which is ...

Boghossian, Ardemis A. (Ardemis Anoush)

2012-01-01T23:59:59.000Z

250

CSNI specialist meeting on leak-before-break in nuclear reactor piping: proceedings  

SciTech Connect

On September 1 and 2, 1983, the CSNI subcommittee on primary system integrity held a special meeting in Monterey, California, on the subject of leak-before-break in nuclear reactor piping systems. The purpose of the meeting was to provide an international forum for the exchange of ideas, positions, and research results; to identify areas requiring additional research and development; and to determine the general attitude toward acceptance of the leak-before-break concept. The importance of the leak-before-break issue was evidenced by excellent attendance at the meeting and through active participation by the meeting attendees. Approximately 125 people representing fifteen different nations attended the meeting. The meeting was divided into four technical sessions addressing the following areas: Application of Piping Fracture Mechanics to Leak-Before Break, Leak Rate and Leak Detection, Leak-Before-Break Studies, Methods and Results, Current and Proposed Positions on Leak-Before-Break.

Not Available

1984-08-01T23:59:59.000Z

251

ON THE EVOLUTION OF THE SPECTRAL BREAK IN THE AFTERGLOW OF GAMMA-RAY BURSTS  

Science Conference Proceedings (OSTI)

The temporal evolution of the spectral break in the time-resolved spectral energy density of the broadband afterglow of gamma-ray bursts (GRBs) 091127 and 080319B was shown recently to be inconsistent with that expected for the cooling break in the standard fireball model of GRBs. Here we show that it is, however, in good agreement with the predicted temporal evolution of the smooth injection break/bend in the cannonball model of GRBs.

Dado, Shlomo; Dar, Arnon [Physics Department, Technion, Haifa 32000 (Israel)

2012-02-20T23:59:59.000Z

252

Troubleshooting, Maintaining, and Repairing Personal Computers: A Technician's Guide  

Science Conference Proceedings (OSTI)

From the Publisher:Efficient, cost-effective troubleshooting and repair techniques in the ultimate hands-on reference for technicians. With this book and your technical skills, there is no computer problem you can't correct. You'll find nearly 400 problems ...

Stephen J. Bigelow

1995-11-01T23:59:59.000Z

253

Thermosetting Polymer-Matrix Composites for Strucutral Repair Applications  

Science Conference Proceedings (OSTI)

Several classes of thermosetting polymer matrix composites were evaluated for use in structural repair applications. Initial work involved the characterization and evaluation of woven carbon fiber/epoxy matrix composites for structural pipeline repair. Cyanate ester resins were evaluated as a replacement for epoxy in composites for high-temperature pipe repair applications, and as the basis for adhesives for resin infusion repair of high-temperature composite materials. Carbon fiber/cyanate ester matrix composites and fumed silica/cyanate ester nanocomposites were evaluated for their thermal, mechanical, viscoelastic, and rheological properties as they relate to their structure, chemistry, and processing characteristics. The bisphenol E cyanate ester under investigation possesses a high glass transition temperature, excellent mechanical properties, and unique ambient temperature processability. The incorporate of fumed silica served to enhance the mechanical and rheological properties of the polymer and reduce thermal expansion without sacrificing glass transition or drastically altering curing kinetics. Characterization of the composites included dynamic mechanical analysis, thermomechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy.

William Kirby Goertzen

2007-12-01T23:59:59.000Z

254

Charge transport-mediated recruitment of DNA repair enzymes  

E-Print Network (OSTI)

Damaged or mismatched bases in DNA can be repaired by Base Excision Repair (BER) enzymes that replace the defective base. Although the detailed molecular structures of many BER enzymes are known, how they colocalize to lesions remains unclear. One hypothesis involves charge transport (CT) along DNA [Yavin, {\\it et al.}, PNAS, {\\bf 102}, 3546, (2005)]. In this CT mechanism, electrons are released by recently adsorbed BER enzymes and travel along the DNA. The electrons can scatter (by heterogeneities along the DNA) back to the enzyme, destabilizing and knocking it off the DNA, or, they can be absorbed by nearby lesions and guanine radicals. We develop a stochastic model to describe the electron dynamics, and compute probabilities of electron capture by guanine radicals and repair enzymes. We also calculate first passage times of electron return, and ensemble-average these results over guanine radical distributions. Our statistical results provide the rules that enable us to perform implicit-electron Monte-Carlo simulations of repair enzyme binding and redistribution near lesions. When lesions are electron absorbing, we show that the CT mechanism suppresses wasteful buildup of enzymes along intact portions of the DNA, maximizing enzyme concentration near lesions.

Pak-Wing Fok; Chin-Lin Guo; Tom Chou

2008-11-18T23:59:59.000Z

255

SOLERAS - Analysis of photovoltaic concentrator module failures and repair methods  

Science Conference Proceedings (OSTI)

This report presents the results of the failure analysis, performed from early 1984 through September 1986 on the open-circuited modules, and the assessment of repairing these modules on site at the Solar Village. 16 refs., 26 figs., 19 tabs.

Huraib, F.S.; Imamura, M.S.; Salim, A.A.; Rao, N.R.

1987-06-01T23:59:59.000Z

256

When Size Matters: Yttrium Oxide Breaking Down Under Pressure | Advanced  

NLE Websites -- All DOE Office Websites (Extended Search)

Breakthrough in Nanocrystals' Growth Breakthrough in Nanocrystals' Growth Next Step to Drought-Resistant Plants? A Boring Material "Stretched" Could Lead to an Electronics Revolution At the Crossroads of Chromosomes Unveiling the Structure of Adenovirus Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed When Size Matters: Yttrium Oxide Breaking Down Under Pressure NOVEMBER 2, 2010 Bookmark and Share Top: Pair distribution function (PDF) of 16 nm-sized Y2O3 at high pressures. Bottom: Lin Wang (left) and Wenge Yang (right) of the Carnegie Institution of Washington shown with the diamond anvil cell and x-ray instrumentation used to probe the PDF of the sample at high applied

257

LANL breaks ground on key sediment control project  

NLE Websites -- All DOE Office Websites (Extended Search)

Sediment control project Sediment control project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately $2 million features are up to eight feet high and made of rocks packed tightly into wire enclosures. November 5, 2009 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

258

A Symmetry Breaking Model for X Chromosome Inactivation  

E-Print Network (OSTI)

In mammals, dosage compensation of X linked genes in female cells is achieved by inactivation of one of their two X chromosomes which is randomly chosen. The earliest steps in X-inactivation (XCI), namely the mechanism whereby cells count their X chromosomes and choose between two equivalent X, remain mysterious. Starting from the recent discovery of X chromosome colocalization at the onset of X-inactivation, we propose a Statistical Mechanics model of XCI, which is investigated by computer simulations and checked against experimental data. Our model describes how a `blocking factor' complex is self-assembled and why only one is formed out of many diffusible molecules, resulting in a spontaneous symmetry breaking (SB) in the binding to two identical chromosomes. These results are used to derive a scenario of biological implications describing all current experimental evidences, e.g., the importance of colocalization.

M. Nicodemi; A. Prisco

2008-01-17T23:59:59.000Z

259

Universality and Symmetry Breaking in Conformally Reduced Quantum Gravity  

E-Print Network (OSTI)

The scaling properties of quantum gravity are discussed by employing a class of proper-time regulators in the functional flow equation for the conformal factor within the formalism of the background field method. Renormalization group trajectories obtained by projecting the flow on a flat topology are more stable than those obtained from a projection on a spherical topology. In the latter case the ultraviolet flow can be characterized by a Hopf bifurcation with an ultraviolet attractive limiting cycle. Although the possibility of determining the infrared flow for an extended theory space can be severely hampered due to the conformal factor instability, we present a robust numerical approach to study the flow structure around the non-gaussian fixed point as an inverse-problem strategy. In particular it is shown the possibility of having a spontaneous breaking of the diffeomorphism invariance can be realized with non-local functionals of the volume operator.

Bonanno, Alfio

2012-01-01T23:59:59.000Z

260

Breaking Records in Neurological Microradiology | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Exposing Valence-Bond Model Inadequacies Exposing Valence-Bond Model Inadequacies Plants' Rapid Response System Revealed Rewriting the Organofluorine Playbook Computer-Designed Proteins to Disarm a Variety of Flu Viruses Driving Membrane Curvature Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Breaking Records in Neurological Microradiology AUGUST 9, 2012 Bookmark and Share A dense neuron cluster including details of cells in deeper tissue layers. As neuroscientists probe ever deeper into the mysteries of the brain and nervous system, they need ever sharper vision. A group of researchers has developed some exciting new techniques for imaging neuronal and synaptic networks using the hard synchrotron x-rays

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Proceedings: Welding and Repair Technology for Power Plants: Second International Conference  

Science Conference Proceedings (OSTI)

The conference on welding and repair technology for power plants included presentations of case histories, emerging welding technologies, and demonstrated repair techniques and approaches. These proceedings provide technical information discussed at the conference on the repair of turbine rotors, disks, blades, piping, steam generators, headers, reactor pressure vessel internals, valves, pumps, and other components.

1997-04-04T23:59:59.000Z

262

Technical Repair Guidelines for Limitorque Gear Operator Models HBC 0-10  

Science Conference Proceedings (OSTI)

This technical repair guide (TRG) for Limitorque gear operator models HBC-0 through HBC-10 is the fourth in a series of documents devoted to the comprehensive maintenance and repair of Limitorque valve actuators. This guide provides instructions for engineering, operations, and maintenance personnel on the repair, maintenance, and operation of Limitorque HBC gear operators and their accessories.

1993-10-02T23:59:59.000Z

263

Description of Past Research: Fossil Materials and Repair (Program 87): 2012 Update  

Science Conference Proceedings (OSTI)

The Electric Power Research Institute’s (EPRI’s) Fossil Materials and Repair Program (Program 87) within Major Component Reliability provides integrated materials selection guidance, information about repair technology, and corrosion mitigation methods to improve equipment performance, reliability, and profitability. The program has produced numerous material and repair guidelines and handbooks for application with steam boilers, steam ...

2013-04-12T23:59:59.000Z

264

Technical Repair Guidelines for Limitorque Models SMB 0 Through 4 Valve Actuators  

Science Conference Proceedings (OSTI)

This technical repair guide for Limitorque motor-operated valve (MOV) actuator models SMB 0 through 4 represents the third in a series of documents devoted to the comprehensive maintenance and repair of Limitorque actuators. This guide provides instructions for engineering, operations, and maintenance personnel on MOV actuator repair, maintenance, adjustment, and troubleshooting methods.

1993-02-28T23:59:59.000Z

265

Welding and Repair Technology for Power Plants: Fourth RRAC International Conference  

Science Conference Proceedings (OSTI)

The Fourth International Conference on Welding and Repair Technology for Power Plants included presentations of case histories and emerging welding technologies and demonstrations of repair techniques and approaches. These proceedings provide technical information discussed during this conference regarding the repair of steam turbine rotors, discs, blades, piping, steam generators, headers, reactor pressure vessel internals, valves, pumps, combustion turbines, and other components. Sessions included nucl...

2000-09-30T23:59:59.000Z

266

The vascular flora of Breaks Interstate Park, Pike County, Kentucky, and Dickenson County, Virginia.  

E-Print Network (OSTI)

??The vascular flora of Breaks Interstate Park was documented during two growing seasons, 2008 and 2009; with supplemental collections made in 2010 and 2011. The… (more)

Clark, Julie Bennett

2012-01-01T23:59:59.000Z

267

Valve Application, Maintenance, and Repair Guide: In Situ State-of-the-Art Valve Welding Repair (Gate, Globe, & Check Valves), Volum e 2  

Science Conference Proceedings (OSTI)

The Valve Application, Maintenance and Repair Guide is a three volume series that provides a generic overview of valve application selection, maintenance, and repair. Volume 2 of this series is a comprehensive guide for in situ weld repair of gate, globe, and check valve components such as bodies, bonnets, discs, and seats. The information in this guide, though directed toward nuclear plant personnel, will assist all power plant engineers, planners, and maintenance personnel responsible for valve mainten...

1996-12-31T23:59:59.000Z

268

Breaking Up Breaking Up  

E-Print Network (OSTI)

Administration EPRI Electric Power Research Institute EV Electric Vehicle FERC Federal Energy Regulatory (FERC) Chairman Jon Wellinghoff has called demand response the "killer app" of the smart grid (FERC of households. A study prepared for FERC estimated that demand response programs, if fully deployed, could cut U

de Lijser, Peter

269

Enhancement of the RAD51 Recombinase Activity by the Tumor Suppressor PALB2  

SciTech Connect

Homologous recombination mediated by the RAD51 recombinase helps eliminate chromosomal lesions, such as DNA double-stranded breaks induced by radiation or arising from injured DNA replication forks. The tumor suppressors BRCA2 and PALB2 act together to deliver RAD51 to chromosomal lesions to initiate repair. Here we document a new function of PALB2 in the enhancement of RAD51's ability to form the D-loop. We show that PALB2 binds DNA and physically interacts with RAD51. Importantly, while PALB2 alone stimulates D-loop formation, a cooperative effect is seen with RAD51AP1, an enhancer of RAD51. This stimulation stems from PALB2's ability to function with RAD51 and RAD51AP1 to assemble the synaptic complex. Our results help unveil a multi-faceted role of PALB2 in chromosome damage repair. Since PALB2 mutations can cause breast and other tumors or lead to Fanconi anemia, our findings are important for understanding the mechanism of tumor suppression in humans.

Dray, Eloise; Etchin, Julia; Wiese, Claudia; Saro, Dorina; Williams, Gareth J.; Hammel, Michal; Yu, Xiong; Galkin, Vitold E.; Liu, Dongqing; Tsai, Miaw-Sheue; Sy, Shirley M-H.; Egelman, Edward; Chen, Junjie; Sung, Patrick; Schild, D.

2010-08-24T23:59:59.000Z

270

Effects of Wave Breaking on the Near-Surface Profiles of Velocity and Turbulent Kinetic Energy  

Science Conference Proceedings (OSTI)

A theoretical model for the near-surface velocity profile in the presence of breaking waves is presented. Momentum is accumulated by growing waves and is released upon wave breaking. In effect, such a transition is a process involving a time-...

Arne Melsom; Øyvind SÆtra

2004-02-01T23:59:59.000Z

271

A particle-based method for large-scale breaking waves simulation  

Science Conference Proceedings (OSTI)

We address in this paper the problem of particle-based simulation of breaking waves. We present a new set of equations based on oceanographic research which allow us to deal with several types of breaking waves and multiple wave trains with full control ...

Emmanuelle Darles; Benoit Crespin; Djamchid Ghazanfarpour

2010-09-01T23:59:59.000Z

272

WaveTurbulence Interactions in a Breaking Mountain Wave CRAIG C. EPIFANIO AND TINGTING QIAN  

E-Print Network (OSTI)

-breaking calculations. Of particular interest are the turbulent heat and momentum fluxes in the breaking wave fluxes on grid spacing is considered by computing a series of ensembles with grid spacings ranging from L are mostly resolved, but with increasing grid spacing, the resolved-scale fluxes decline

273

Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities  

DOE Green Energy (OSTI)

Grid parity--or break-even cost--for photovoltaic (PV) technology is defined as the point where the cost of PV-generated electricity equals the cost of electricity purchased from the grid. Break-even cost is expressed in $/W of an installed system. Achieving break-even cost is a function of many variables. Consequently, break-even costs vary by location and time for a country, such as the United States, with a diverse set of resources, electricity prices, and other variables. In this report, we analyze PV break-even costs for U.S. residential customers. We evaluate some key drivers of grid parity both regionally and over time. We also examine the impact of moving from flat to time-of-use (TOU) rates, and we evaluate individual components of the break-even cost, including effect of rate structure and various incentives. Finally, we examine how PV markets might evolve on a regional basis considering the sensitivity of the break-even cost to four major drivers: technical performance, financing parameters, electricity prices and rates, and policies. We find that local incentives rather than ?technical? parameters are in general the key drivers of the break-even cost of PV. Additionally, this analysis provides insight about the potential viability of PV markets.

Denholm, P.; Margolis, R. M.; Ong, S.; Roberts, B.

2009-12-01T23:59:59.000Z

274

Photo of the Week: Record-Breaking Solar Cells | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Photo of the Week: Record-Breaking Solar Cells Photo of the Week: Record-Breaking Solar Cells Photo of the Week: Record-Breaking Solar Cells December 7, 2012 - 2:27pm Addthis Solar Junction, in partnership with NREL, has developed solar cells that reach a record-breaking 44 percent efficiency -- meaning that more than 40 percent of the sunlight the solar cells are exposed to is converted into electrical energy. In this photo, an operator inspects a photolithography tool used to manufacture these solar cells. | Photo by Daniel Derkacs/SolarJunction. Solar Junction, in partnership with NREL, has developed solar cells that reach a record-breaking 44 percent efficiency -- meaning that more than 40 percent of the sunlight the solar cells are exposed to is converted into electrical energy. In this photo, an operator inspects a photolithography

275

Photo of the Week: Record-Breaking Solar Cells | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Record-Breaking Solar Cells Record-Breaking Solar Cells Photo of the Week: Record-Breaking Solar Cells December 7, 2012 - 2:27pm Addthis Solar Junction, in partnership with NREL, has developed solar cells that reach a record-breaking 44 percent efficiency -- meaning that more than 40 percent of the sunlight the solar cells are exposed to is converted into electrical energy. In this photo, an operator inspects a photolithography tool used to manufacture these solar cells. | Photo by Daniel Derkacs/SolarJunction. Solar Junction, in partnership with NREL, has developed solar cells that reach a record-breaking 44 percent efficiency -- meaning that more than 40 percent of the sunlight the solar cells are exposed to is converted into electrical energy. In this photo, an operator inspects a photolithography

276

Solar Cells, Wound Repair Winning GVC Technologies | ornl.gov  

NLE Websites -- All DOE Office Websites (Extended Search)

Solar Cells, Wound Repair Winning GVC Technologies Solar Cells, Wound Repair Winning GVC Technologies March 26, 2010 Graduate student teams from the University of Arkansas and the University of Maryland earned first place in the energy and security categories at the 2010 GVC hosted by ORNL March 24-26. The competition, in its fourth year, attracts students developing new technologies and venture investors with expertise in the market. The first-prize winners each received $25,000. Douglas Hutchings, Stephen Ritterbush, and Seth Shumate from Arkansas won first place in the energy division for Silicon Solar Solutions. "Our method replaces the expensive top layer of solar cells with a thinner, large-grain polysilicon at lower temperatures, which reduces cost and is appealing to manufacturers," said Ritterbush.

277

Superior refining performance beyond 2000 -- Breaking traditional paradigms  

SciTech Connect

Over the last 5 years, refining companies have not performed well financially, generating returns below the cost of capital. Environmental regulations have caused the industry to invest significant amounts of capital, and while new regulations will cause the shutdown of between 500 thousand and 1.2 million barrels per day of capacity, the industry structure will remain poor and financial returns for the average player will likely be volatile, cyclical, and below the cost of capital. Based on this industry outlook, refining companies seeking superior performance will have to break the traditional paradigms and adopt world-class practices used in other industries. Changes required to significantly improve financial returns will include shifts in business strategy to accommodate growth, and development of nontraditional services, as well as initiates to dramatically reshape cost structure and improve profitability. Making the changes to become a superior performer in the refining business will require a clear vision and strong leadership at multiple levels in the organization. The transformation will also require changes in company culture and incentive plans that encourage managers to act as owners. In addition, superior performers will push accountability for results to low levels in the organization. Given the herd mentality of the oil industry, superior performers must take decisive, preemptive action to generate a substantial, competitive advantage.

Tassel, B. van [McKinsey and Co., Inc., Houston, TX (United States)

1995-09-01T23:59:59.000Z

278

Star Formation and Chemical Evolution of Lyman-Break Galaxies  

E-Print Network (OSTI)

The number density and clustering properties of Lyman-break galaxies (LBGs)observed at redshift $z\\sim 3$ are best explained by assuming that they areassociated with the most massive haloes at $z\\sim 3$ predicted in hierarchicalmodels of structure formation. In this paper we study, under the sameassumption, how star formation and chemical enrichment may have proceeded inthe LBG population. A consistent model, in which the amount of cold gasavailable for star formation must be regulated, is suggested. It is found thatgas cooling in dark haloes provides a natural regulation process. In thismodel, the star formation rate in an LBG host halo is roughly constant overabout 1 Gyr. The predicted star formation rates and effective radii areconsistent with observations. The metallicity of the gas associated with an LBGis roughly equal to the chemical yield, or about the order of $1 Z_{\\odot}$ fora Salpeter IMF. The contribution to the total metals of LBGs is roughlyconsistent with that obtained from the observed cosmic...

Shu, C

2000-01-01T23:59:59.000Z

279

Star Formation and Chemical Evolution of Lyman-Break Galaxies  

E-Print Network (OSTI)

The number density and clustering properties of Lyman-break galaxies (LBGs) observed at redshift $z\\sim 3$ are best explained by assuming that they are associated with the most massive haloes at $z\\sim 3$ predicted in hierarchical models of structure formation. In this paper we study, under the same assumption, how star formation and chemical enrichment may have proceeded in the LBG population. A consistent model, in which the amount of cold gas available for star formation must be regulated, is suggested. It is found that gas cooling in dark haloes provides a natural regulation process. In this model, the star formation rate in an LBG host halo is roughly constant over about 1 Gyr. The predicted star formation rates and effective radii are consistent with observations. The metallicity of the gas associated with an LBG is roughly equal to the chemical yield, or about the order of $1 Z_{\\odot}$ for a Salpeter IMF. The contribution to the total metals of LBGs is roughly consistent with that obtained from the observed cosmic star formation history. The model predicts a marked radial metallicity gradient in a galaxy, with the gas in the outer region having much lower metallicity. As a result, the metallicities for the damped Lyman-alpha absorption systems expected from the LBG population are low. Since LBG halos are filled with hot gas in this model, their contributions to the soft X-ray background and to the UV ionization background are calculated and discussed.

Chenggang Shu

2000-02-21T23:59:59.000Z

280

Treatment methods for breaking certain oil and water emulsions  

DOE Patents (OSTI)

Disclosed are treatment methods for breaking emulsions of petroleum oil and salt water, fatty oil and water, and those resulting from liquefication of organic material. The emulsions are broken by heating to a predetermined temperature at or above about 200.degree. C. and pressurizing to a predetermined pressure above the vapor pressure of water at the predetermined temperature to produce a heated and pressurized fluid. The heated and pressurized fluid is contained in a single vessel at the predetermined temperature and pressure for a predetermined period of time to effectively separate the emulsion into substantially distinct first and second phases, the first phase comprising primarily the petroleum oil, the second phase comprising primarily the water. The first and second phases are separately withdrawn from the vessel at a withdraw temperature between about 200.degree. C. and 374.degree. C. and a withdraw pressure above the vapor pressure of water at the withdraw temperature. Where solids are present in the certain emulsions, the above described treatment may also effectively separate the certain emulsion into a substantially distinct third phase comprising primarily the solids.

Sealock, Jr., L. John (W. Richland, WA); Baker, Eddie G. (Richland, WA); Elliott, Douglas C. (Richland, WA)

1992-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Higgs boson mass bounds separate models of electroweak symmetry breaking  

SciTech Connect

Vacuum stability and metastability imply lower limits on the mass of the Higgs boson in the standard model (SM). In contrast, we present an improved calculation of the lightest Higgs boson mass in supersymmetric (SUSY) models, by summing to all orders in perturbation theory the leading and next-to-leading logarithms with a renormalization group equation technique, and by including finite two-loop QCD corrections. We believe our result to be the most accurate available in the literature. The mass calculation leads to an upper bound on the Higgs boson mass when the SUSY-breaking scale is sensibly restricted to {approx_lt}1 TeV. In particular, our improvements to the SUSY Higgs boson mass calculation lower the minimal SUSY standard model (MSSM) upper limit by about 10 GeV. We study the possibility that these SM and MSSM bounds do not overlap, in which case a single Higgs boson mass measurement will distinguish between the two models. (Abstract Truncated)

Diaz, M.A. [Physics Department, University of Southampton, Southampton, SO17 1BJ (United Kingdom); ter Veldhuis, T.A.; Weiler, T.J. [Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235 (United States)

1996-11-01T23:59:59.000Z

282

ULTRASONIC DETECTION OF SURFACE-BREAKING RAILHEAD DEFECTS  

Science Conference Proceedings (OSTI)

We recently presented measurements of defects on the railhead, using a novel pitch-catch ultrasonic system comprising of two electro-magnetic acoustic transducers (EMATs) generating and detecting Rayleigh waves. Current systems used on the UK rail network for detecting surface breaking defects are limited in speed (5 mm). The non-contact EMAT system has the potential to operate at higher line speed, improving network inspection coverage. The current system detects signals and performs an FFT in less than 1 ms, and changes in the detected signal amplitude and frequency content are used to characterise defects. A new set of simulated defects on sections of rail have been produced, including half-face slots machined normal to the railhead surface, clusters of angled slots, and pocket defects more typical of real defects. The smallest pocket defects are difficult to detect, with changes in signal amplitude and cut-off falling close to the noise level. However, at chosen higher frequencies a drop in FFT magnitude indicates the presence of a defect, and this indicator can be logically combined with amplitude and cut-off measurements to provide a more reliable result. Preparation for testing on a rotating rail rig at high speeds is ongoing.

Edwards, R. S.; Fan, Y.; Dixon, S. [University of Warwick, Department of Physics, Coventry CV4 7AL (United Kingdom); Papaelias, M.; Davis, C. L.; Roberts, C. [University of Birmingham, School of Engineering, Birmingham (United Kingdom)

2008-02-28T23:59:59.000Z

283

Repair and Replacement Applications Center Joint Welding Procedure Qualification Program  

Science Conference Proceedings (OSTI)

At the request of the EPRI Repair and Replacement Applications Center subscribers, a Joint Welding Procedure Qualification Program was developed to provide a medium whereby multiple utilities can share in the qualification of specific welding procedures. The program was developed in such a manner that it will supplement existing utility welding qualification programs. Specifically the program incorporates the more stringent attributes of each utility's internal welding program while meeting the individua...

1997-11-12T23:59:59.000Z

284

In Situ Temporary Repair of Thermal Barrier Coatings  

Science Conference Proceedings (OSTI)

The durability of thermal barrier coatings (TBCs) on combustion turbine blades and vanes is a critical issue in the power generation industry. Degradation of TBCs occur by the spallation of the ceramic layer — partially stabilized zirconia (PSZ) — that resides on the Al2O3-covered MCrAlY bondcoat. In the event of such local failures of the TBC, a quick in-situ technique to repair the coating would be desirable.

2005-03-31T23:59:59.000Z

285

Development of Methods to Repair Header Stub Tube Bends  

Science Conference Proceedings (OSTI)

Repair of flow-accelerated corrosion damage in bent header stub tubes in heat recovery steam generators (HRSGs) is normally accomplished by spreading tubing pendants to gain access, cutting your way in and welding your way out, or plugging damaged tubing. The technology described in this report is being developed to enable the replacement of damaged tubing in a method that will dramatically reduce change-out time in the event of a failure.

2008-12-23T23:59:59.000Z

286

HRSG Repair Welding Technologies to Address FAC in Tube Bends  

Science Conference Proceedings (OSTI)

Tube failures that occur in heat recovery steam generators (HRSGs) are often caused by thermal stress or thermal shock associated with cyclic plant operation or by flow-accelerated corrosion. Many premature failures occur along the length of finned tubes or at attachment locations where tubes are joined to the upper or lower header. Because of current tube repair practices and limited access for welding, reoccurring failures are common.

2008-03-20T23:59:59.000Z

287

Repair Welding Technologies For Heat Recovery Steam Generators  

Science Conference Proceedings (OSTI)

Tube failures that occur in heat recovery steam generators (HRSGs) are often caused by thermal stress or thermal shock associated with cyclic plant operation or by flow-accelerated corrosion. Many premature failures occur along the length of finned tubes or at attachment locations where tubes are joined to the upper or lower header. Because of current tube repair practices and limited access for welding, reoccurring failures are common.

2005-12-21T23:59:59.000Z

288

Impact of Breaking Wave Form Drag on Near-Surface Turbulence and Drag Coefficient over Young Seas at High Winds  

Science Conference Proceedings (OSTI)

The effects of breaking waves on near-surface wind turbulence and drag coefficient are investigated using large-eddy simulation. The impact of intermittent and transient wave breaking events (over a range of scales) is modeled as localized form ...

Nobuhiro Suzuki; Tetsu Hara; Peter P. Sullivan

2013-02-01T23:59:59.000Z

289

Making and breaking of water in crude oil emulsions  

E-Print Network (OSTI)

An understanding of the processes involved in oil spills, and how they interact to alter the composition and behavior of the oil with respect to time is essential to determine an effective oil spill response. The review of past research has shown more focus on the laboratory methods and computerized modeling schemes to estimate the formation and breaking of emulsions after an oil spill. However, relatively less effort has gone into the study of emulsions corresponding to actual field conditions. This research aims to simulate an oil spill at sea by developing a new technique to make water in oil emulsions, without disturbing the marine wildlife. Further, this research also attempts to analyze the viscosities of water in oil emulsions and determine appropriate emulsion breakers for different crude oil emulsions. The overall test design for the study includes a test apparatus for spreading and evaporation, three different crude oils, a mixing chamber to form the emulsion, and emulsion breakers. Experiments in this research attempt to gain a better understanding of the processes that occur after oil spills at sea. In particular, the rate of evaporation of different crude oils and the formation of crude oil emulsions on the sea surface have been investigated. It was observed that different crude oils behave differently when subjected to the same weathering procedure. Results indicate that the behavior of the crude oil on the sea surface, subjected to spreading, evaporation, and emulsification, can be predicted by using the new technique developed in this research. This technique can also assist the development of effective recovery equipments and materials.

Mehta, Shweta D.

2005-12-01T23:59:59.000Z

290

Design Considerations for Monopile Founded Offshore Wind Turbines Subject to Breaking Waves  

E-Print Network (OSTI)

The majority of offshore wind farms utilize monopile substructures. As these wind farms are typically located in water depths less than 30 meters, the effect of breaking waves on these structures is of great concern to design engineers. This research investigation examines many of the practical considerations and alternative ways of estimating breaking wave forces. A survey of existing European wind farms is used to establish a realistic range of basic design parameters. Based upon this information a parametric study was pursued and a series of realistic design scenarios were evaluated. Comparisons include the sensitivity to the wave force model as well as to analytical and numerical wave theories used to evaluate the wave kinematics. In addition, the effect of different kinematics stretching techniques for linear waves is addressed. Establishing whether the bathymetry will induce spilling or plunging wave breaking is critical. Spilling wave breaking can be addressed using existing wave and wave force theories; however for plunging wave breaking an additional impact force must be introduced. Dimensionless design curves are used to display pertinent trends across the full range of design cases considered. This research study provides insight into the evaluation of the maximum breaking wave forces and overturning moment for both spilling and plunging breaking waves as a function of bottom slope.

Owens, Garrett 1987-

2012-12-01T23:59:59.000Z

291

Particle-Hole Symmetry Breaking in the Pseudogap State of Bi2201  

Science Conference Proceedings (OSTI)

In conventional superconductors, a gap exists in the energy absorption spectrum only below the transition temperature (T{sub c}), corresponding to the energy price to pay for breaking a Cooper pair of electrons. In high-T{sub c} cuprate superconductors above T{sub c}, an energy gap called the pseudogap exists, and is controversially attributed either to pre-formed superconducting pairs, which would exhibit particle-hole symmetry, or to competing phases which would typically break it. Scanning tunnelling microscopy (STM) studies suggest that the pseudogap stems from lattice translational symmetry breaking and is associated with a different characteristic spectrum for adding or removing electrons (particle-hole asymmetry). However, no signature of either spatial or energy symmetry breaking of the pseudogap has previously been observed by angle-resolved photoemission spectroscopy (ARPES). Here we report ARPES data from Bi2201 which reveals both particle-hole symmetry breaking and dramatic spectral broadening indicative of spatial symmetry breaking without long range order, upon crossing through T* into the pseudogap state. This symmetry breaking is found in the dominant region of the momentum space for the pseudogap, around the so-called anti-node near the Brillouin zone boundary. Our finding supports the STM conclusion that the pseudogap state is a broken-symmetry state that is distinct from homogeneous superconductivity.

Hashimoto, M.; /SIMES, Stanford /Stanford U., Geballe Lab. /LBNL, ALS; He, R.-H.; /aff SIMES, Stanford /Stanford U., Geballe Lab.; Tanaka, K.; /aff SIMES, Stanford /Stanford U., Geballe Lab. /LBNL, ALS /Osaka U.; Testaud, J.P.; /SIMES, Stanford /Stanford U., Geballe Lab. /LBNL, ALS; Meevasana1, W.; Moore, R.G.; Lu, D.H.; /SIMES, Stanford /Stanford U., Geballe Lab.; Yao, H.; /SIMES, Stanford; Yoshida, Y.; Eisaki, H.; /AIST, Tsukuba; Devereaux, T.P.; /SIMES, Stanford /Stanford U., Geballe Lab.; Hussain, Z.; /LBNL, ALS; Shen, Z.-X.; /SIMES, Stanford /Stanford U., Geballe Lab.

2011-08-19T23:59:59.000Z

292

One "Cool Tool" That's Helping Repair Your DNA | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

"Cool Tool" That's Helping Repair Your DNA "Cool Tool" That's Helping Repair Your DNA One "Cool Tool" That's Helping Repair Your DNA April 18, 2011 - 1:20pm Addthis Charles Rousseaux Charles Rousseaux Senior Writer, Office of Science What are the key facts? Berkeley Lab's Advanced Light Source produces x-ray light that shines a billion times bright than the sun. Scientists discovered the motor that drives the actual repair of the DNA repair machine called MRN, which is tethered to the rest of the machine in a fairly flexible fashion. Further insight into MRN and other DNA repair machines may also give scientists new insights into fighting some cancers as well as other diseases such as cystic fibrosis. With the arrival of spring, many families are dusting off their tools to make some home improvements. It's worth remembering that nature also has

293

Determining the angles of break of the mining subsidence basin by the neural network with genetic algorithm  

Science Conference Proceedings (OSTI)

The angle of break is a key factor that determines the mining damage extent of the surface in a mine, and it is also used to depict the characteristics of the mining subsidence basin. The geological and mining factors that influence the angle of break ... Keywords: angle of break, genetic algorithm, neural network, subsidence basin

Hua-bin Chai

2010-03-01T23:59:59.000Z

294

Technical Repair Guidelines for Limitorque Model SMB-000 Valve Actuators: Revision 1  

Science Conference Proceedings (OSTI)

This technical repair guide (TRG) for Limitorque motor-operated valve (MOV) actuator model SMB-000 is the first in a series of documents devoted to the comprehensive maintenance and repair of Limitorque actuators. This guide provides instructions for engineering, operations, and maintenance personnel on MOV actuator repair, maintenance, adjustment, and troubleshooting methods. Originally published in 1989, this document has now been thoroughly revised (Revision 1) to incorporate new information and techn...

1994-10-02T23:59:59.000Z

295

Combustion Turbine Repair Guidelines: Siemens V84.3A (SGT6-4000F)  

Science Conference Proceedings (OSTI)

For more than a decade, the Electric Power Research Institute (EPRI) has been developing gas turbine hot section component repair and coating guidelines to assist utilities in the refurbishment of these critical and expensive parts. Utilities, generators, and repair vendors have used these guidelines to perform repairs on blades, turbine vanes, and combustion hardware. Guidelines now exist for a variety of conventional and advanced General Electric, Siemens/Westinghouse, Alstom, and Mitsubishi heavy fram...

2010-01-27T23:59:59.000Z

296

Development of Laser Weld Repair, Cladding, and Heat Treatment Technology for Alloy 600 RPV Penetrations  

Science Conference Proceedings (OSTI)

EPRI has developed innovative laser weld repair technology for Alloy 600 reactor pressure vessel (RPV) head penetrations in pressure water reactors (PWRs). The repair technology consists of an Nd:YAG laser, fiber optic delivery system, optical assembly (weld head), welding filler metal feed system, and manipulator. The laser system will be used to address the repair of axially oriented cracks, stress relief, and cladding operations.

1998-06-29T23:59:59.000Z

297

Conference Proceedings: EPRI-RRAC Fifth International Conference on Welding and Repair Technology for Power Plants  

Science Conference Proceedings (OSTI)

The 2002 Fifth International Conference on Welding and Repair Technology for Power Plants included presentations of case histories, emerging welding technologies, and demonstrated repair techniques and approaches. These proceedings provide technical information discussed during this conference on the repair of steam turbine rotors, disks, blades, piping, steam generators, headers, reactor pressure vessel internals, valves, pumps, combustion turbines, and other components. Sessions include nuclear and fos...

2002-10-17T23:59:59.000Z

298

Note: A Graph-Theoretical Approach to Level of Repair Analysis  

E-Print Network (OSTI)

Aug 29, 2004... of repair and maintenance facilities to minimize overall life-cycle costs. ... Category 2: Applications -- OR and Management Sciences ...

299

Improving Repair Quality of Turbine Nozzles Using SA650 Braze Alloy  

Science Conference Proceedings (OSTI)

improved repairs for key gas turbine components. Airfoil components of High Pressure and Low. Pressure turbines (HPT and LPT) are subject to wear and ...

300

Note: A Graph-Theoretical Approach to Level of Repair Analysis  

E-Print Network (OSTI)

Aug 29, 2004 ... Acquisition Management System at www.ams.mod.uk/ams). ... LORA seeks to determine an optimal provision of repair and maintenance.

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

A sociotechnical framework for understanding infrastructure breakdown and repair  

SciTech Connect

This paper looks at how and why infrastructure is repaired. With a new era of infrastructure spending underway, policymakers need to understand and anticipate the particular technical and political challenges posed by infrastructure repair. In particular, as infrastructure problems are increasingly in the public eye with current economic stimulus efforts, the question has increasingly been asked: why has it been so difficult for the United Statesto devote sustained resources to maintaining and upgrading its national infrastructure? This paper provides a sociotechnical framework for understanding the challenges of infrastructure repair, and demonstrates this framework using a case study of seismic retrofit of freeway bridges in California. The design of infrastructure is quite different from other types of design work even when new infrastructure is being designed. Infrastructure projects are almost always situated within, and must work with, existing infrastructure networks. As a result, compared to design of more discrete technological artifacts, the design of infrastructure systems requires a great deal of attention to interfaces as well as adaptation of design to the constraints imposed by existing systems. Also, because of their scale, infrastructural technologies engage with social life at a level where explicit political agendas may playa central role in the design process. The design and building of infrastructure is therefore often an enormously complex feat of sociotechnical engineering, in which technical and political agendas are negotiated together until an outcome is reached that allows the project to move forward. These sociotechnical settlements often result in a complex balancing of powerful interests around infrastructural artifacts; at the same time, less powerful interests have historically often been excluded or marginalized from such settlements.

Sims, Benjamin H [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

302

Breaking Up - And Making Up - Are Hard To Do | U.S. DOE Office of  

NLE Websites -- All DOE Office Websites (Extended Search)

Breaking Up Breaking Up - And Making Up - Are Hard To Do News Featured Articles 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Science Headlines Presentations & Testimony News Archives Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 12.27.11 Breaking Up - And Making Up - Are Hard To Do But as Office of Science research shows, the results can be electric. Print Text Size: A A A Subscribe FeedbackShare Page It's said that breaking up is hard to do. That's undoubtedly true. And so is making up, as more than a few forlorn hearts have found. But when the lightning does strike, the electricity is lasting. What's true for the affairs of the heart also holds for the affairs of hydrogen, as researchers at the Office of Science's Argonne National

303

Break-up of Pt catalyst surfaces by high CO coverage  

E-Print Network (OSTI)

and atomic arrangement of catalyst surface under reactionof reactant molecules on the catalyst surfaces are the norm.Break-up of Pt catalyst surfaces by high CO coverage Feng

Tao, Feng

2010-01-01T23:59:59.000Z

304

Breaking of Progressive Internal Gravity Waves: Convective Instability and Shear Instability  

Science Conference Proceedings (OSTI)

The breaking of a monochromatic two-dimensional internal gravity wave is studied using a newly developed spectral/pseudospectral model. The model features vertical nonperiodic boundary conditions that ensure a realistic simulation of wave ...

Wei Liu; Francis P. Bretherton; Zhengyu Liu; Leslie Smith; Hao Lu; Christopher J. Rutland

2010-10-01T23:59:59.000Z

305

Breaking Surface Wave Effects on River Plume Dynamics during Upwelling-Favorable Winds  

Science Conference Proceedings (OSTI)

This study examines the dynamics of a buoyant river plume in upwelling-favorable winds, concentrating on the time after separation from the coast. A set of idealized numerical simulations is used to examine the effects of breaking surface gravity ...

Gregory P. Gerbi; Robert J. Chant; John L. Wilkin

2013-09-01T23:59:59.000Z

306

Introduction of Break-Out Session at the International PV Module Quality Assurance Forum (Presentation)  

DOE Green Energy (OSTI)

This presentation outlines review requirements for quality assurance (QA) rating systems, logical design of QA systems, and specific tasks for break-out session 1 of the 2011 International PV Module Quality Assurance Forum.

Kurtz, S.; Wohlgemuth, J.; Yamamichi, M.; Sample, T.

2011-07-01T23:59:59.000Z

307

Physics and learning based computational models for breaking bow waves based on new boundary immersion approaches  

E-Print Network (OSTI)

A ship moving on the free surface produces energetic breaking bow waves which generate spray and air entrainment. Present experimental, analytic, and numerical studies of this problem are costly, inaccurate and not robust. ...

Weymouth, Gabriel David

2008-01-01T23:59:59.000Z

308

Simulation of Inertia–Gravity Waves in a Poleward-Breaking Rossby Wave  

Science Conference Proceedings (OSTI)

Poleward-breaking Rossby waves often induce an upper-level jet streak over northern Europe. Dominant inertia–gravity wave packets are observed downstream of this jet. The physical processes of their generation and propagation, in such a ...

Christoph Zülicke; Dieter Peters

2006-12-01T23:59:59.000Z

309

Spectrally Resolved Energy Dissipation Rate and Momentum Flux of Breaking Waves  

Science Conference Proceedings (OSTI)

Video observations of the ocean surface taken from aboard the Research Platform FLIP reveal the distribution of the along-crest length and propagation velocity of breaking wave crests that generate visible whitecaps. The key quantity assessed is ...

Johannes R. Gemmrich; Michael L. Banner; Chris Garrett

2008-06-01T23:59:59.000Z

310

The Nature of the Far-UV Break in the Energy Distribution of Quasars  

E-Print Network (OSTI)

A prominent continuum steepening is observed in quasar energy distributions near 1100A. We review possible interpretations for the physical origin of this so-called far-UV break.

L. Binette; S. Haro-Corzo; Y. Krongold; A. C. Andersen

2007-06-13T23:59:59.000Z

311

Breaks in presence in virtual environments: An analysis of blood flow velocity responses  

Science Conference Proceedings (OSTI)

One of the techniques used to monitor variations in presence during a virtual reality experience is the analysis of breaks in presence (BIPs). Previous studies have monitored peripheral physiological responses during BIPs in order to find a characteristic ...

Beatriz Rey; Vera Parkhutik; Mariano Alcañiz

2011-06-01T23:59:59.000Z

312

About Spontaneous Symmetry Breaking in the Field Theory with Fundamental Mass  

E-Print Network (OSTI)

The simple examples of spontaneous breaking of various symmetries for the scalar theory with fundamental mass have been considered. Higgs generalizations on "fundamental mass" were introduced into the theory on a basis of the five-dimensional de Sitter space.

Umida Khodjaeva

2006-02-28T23:59:59.000Z

313

TRAC large-break loss-of-coolant accident analysis for the AP600 design  

Science Conference Proceedings (OSTI)

This report discusses a TRAC model of the Westinghouse AP600 advanced reactor design which has been developed for analyzing large-break loss-of-coolant accident (LBLOCA) transients. A preliminary LBLOCA calculation of a 80% cold-leg break has been performed with TRAC-PF1/MOD2. The 80% break size was calculated by Westinghouse to be the most severe large-break size. The LBLOCA transient was calculated to 92 s. Peak clad temperatures (PCT) were well below the Appendix K limit of 1478 K (2200{degrees}F). Transient event times and PCT for the TRAC calculation were in reasonable agreement with those calculated by Westinghouse using their WCOBRA/TRAC code.

Lime, J.F.; Boyack, B.E.

1994-02-01T23:59:59.000Z

314

Breaking Surface Wave Effects on River Plume Dynamics during Upwelling-Favorable Winds  

Science Conference Proceedings (OSTI)

This study examines the dynamics of a buoyant river plume in upwelling favorable winds, concentrating on the time after separation from the coast. A set of idealized numerical simulations is used to examine the effects of breaking surface gravity ...

Gregory P. Gerbi; Robert J. Chant; John L. Wilkin

315

Statistics of Breaking Waves Observed as Whitecaps in the Open Sea  

Science Conference Proceedings (OSTI)

Conventional observations of waves carried out with a buoy in open sea conditions were supplemented with simultaneous visual observations of whitecaps to identify breaking events in the buoy records. A statistical wave-by-wave analysis of these ...

L. H. Holthuijsen; T. H. C. Herbers

1986-02-01T23:59:59.000Z

316

Observation of an Anticyclonic Eddy near the Continental Shelf Break South of New England  

Science Conference Proceedings (OSTI)

A small scale but energetic and highly nonlinear anticyclonic eddy was observed near the New England Shelf Break in July 1983. Satellite images show a tongue of shelf water 15 km wide flowing offshore then turning anticyclonically westward. ...

Robert W. Houghton; Donald B. Olson; Peter J. Celone

1986-01-01T23:59:59.000Z

317

A Spectral Parameterization of Mean-Flow Forcing due to Breaking Gravity Waves  

Science Conference Proceedings (OSTI)

A spectral parameterization of mean-flow forcing due to breaking gravity waves is described for application in the equations of motion in atmospheric models. The parameterization is based on linear theory and adheres closely to fundamental ...

M. J. Alexander; T. J. Dunkerton

1999-12-01T23:59:59.000Z

318

A Seasonal Climatology of Rossby Wave Breaking in the 320–2000-K Layer  

Science Conference Proceedings (OSTI)

Differential advection in Rossby waves can lead to potential vorticity (PV; P) contours on isentropic surfaces folding over in latitude (Py < 0) in a process called Rossby wave breaking (RWB). Exploring the properties of RWB may shed light on ...

Matthew H. Hitchman; Amihan S. Huesmann

2007-06-01T23:59:59.000Z

319

A Fourier-Based Method for the Distribution of Breaking Crests from Video Observations  

Science Conference Proceedings (OSTI)

A Fourier-based method is presented to process video observations of water waves and calculate the speed distribution of breaking crest lengths. The method has increased efficiency and robust statistics compared with conventional algorithms that ...

Jim Thomson; Andrew T. Jessup

2009-08-01T23:59:59.000Z

320

Rossby Wave Breaking and Transport between the Tropics and Extratropics above the Subtropical Jet  

Science Conference Proceedings (OSTI)

Rossby wave breaking is an important mechanism for the two-way exchange of air between the tropical upper troposphere and lower stratosphere and the extratropical lower stratosphere. The authors present a 30-yr climatology (1981–2010) of ...

Cameron R. Homeyer; Kenneth P. Bowman

2013-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
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321

Impact of Rossby wave breaking on U.S. west coast winter precipitation during ENSO events  

Science Conference Proceedings (OSTI)

This study demonstrates that water vapor transport and precipitation are largely modulated by the intensity of the subtropical jet, transient eddies, and the location of wave breaking events during the different phases of ENSO. Clear differences ...

Ju-Mee Ryoo; Yohai Kaspi; Darryn W. Waugh; George N. Kiladis; Duane E. Waliser; Eric J. Fetzer; Jinwon Kim

322

Blade reliability collaborative : collection of defect, damage and repair data.  

SciTech Connect

The Blade Reliability Collaborative (BRC) was started by the Wind Energy Technologies Department of Sandia National Laboratories and DOE in 2010 with the goal of gaining insight into planned and unplanned O&M issues associated with wind turbine blades. A significant part of BRC is the Blade Defect, Damage and Repair Survey task, which will gather data from blade manufacturers, service companies, operators and prior studies to determine details about the largest sources of blade unreliability. This report summarizes the initial findings from this work.

Ashwill, Thomas D.; Ogilvie, Alistair B.; Paquette, Joshua A.

2013-04-01T23:59:59.000Z

323

Supersymmetry Breaks Itself for Quarks and Leptons in the SUSY Standard Model  

E-Print Network (OSTI)

Models like the Supersymmetric Standard Model (SSM) possess simple, but well-hidden, `Outfields'. These Outfields are composite operators that violate superspace invariance, but in a special way. A new mechanism for SUSY breaking arises from the Outfields, for a special non-minimal version of the SSM, which will be called the CSSM. The CSSM has right neutrinos and a Higgs singlet, which we call J, in addition to the usual SSM. This breaking of SUSY cannot be avoided, because it arises from the local BRST cohomology of the theory, which is also the origin of the Outfields. It can also be seen that the Weak SU(2) group, and the well-known remarkable set of doublets and singlets for the Quarks, Leptons and Higgs, have a raison d'etre which relates to this mechanism. The SUSY breaking here depends on only one parameter, which is the VEV that breaks SU(2) X U(1) to U(1). SUSY itself is not spontaneously broken here, so the vacuum energy remains zero after SUSY breaking. The resulting predictions for SUSY breaking are very constrained by the model.

John A. Dixon

2010-12-21T23:59:59.000Z

324

Garcinol, a Histone Acetyltransferase Inhibitor, Radiosensitizes Cancer Cells by Inhibiting Non-Homologous End Joining  

SciTech Connect

Purpose: Non-homologous end joining (NHEJ), a major pathway used to repair DNA double-strand breaks (DSBs) generated by ionizing radiation (IR), requires chromatin remodeling at DSB sites through the acetylation of histones by histone acetyltransferases (HATs). However, the effect of compounds with HAT inhibitory activities on the DNA damage response (DDR), including the NHEJ and cell cycle checkpoint, as well as on the radiosensitivity of cancer cells, remains largely unclear. Here, we investigated whether garcinol, a HAT inhibitor found in the rinds of Garcinia indica fruit (called mangosteens), has effects on DDR, and whether it can be used for radiosensitization. Methods and Materials: The following assays were used to examine the effect of garcinol on the inhibition of DSB repair, including the following: a conventional neutral comet assay; a cell-based assay recently developed by us, in which NHEJ repair of DSBs on chromosomal DNA was evaluated; the micrococcal nuclease sensitivity assay; and immunoblotting for autophosphorylation of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). We assessed the effect of garcinol on the cell cycle checkpoint after IR treatment by analyzing the phosphorylation levels of checkpoint kinases CHK1 and CHK2 and histone H3, and by cell cycle profile analysis using flow cytometry. The radiosensitizing effect of garcinol was assessed by a clonogenic survival assay, whereas its effects on apoptosis and senescence were examined by annexin V and senescence-associated {beta}-galactosidase (SA-{beta}-Gal) staining, respectively. Results: We found that garcinol inhibits DSB repair, including NHEJ, without affecting cell cycle checkpoint. Garcinol radiosensitized A549 lung and HeLa cervical carcinoma cells with dose enhancement ratios (at 10% surviving fraction) of 1.6 and 1.5, respectively. Cellular senescence induced by IR was enhanced by garcinol. Conclusion: These results suggest that garcinol is a radiosensitizer that inhibits NHEJ and facilitates senescence without impairing activation of the cell cycle checkpoint.

Oike, Takahiro [Division of Multistep Carcinogenesis, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan) [Division of Multistep Carcinogenesis, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan); Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan); Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma (Japan); Ogiwara, Hideaki [Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan)] [Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan); Torikai, Kohta [Gunma University Heavy Ion Medical Center, Maebashi, Gunma (Japan)] [Gunma University Heavy Ion Medical Center, Maebashi, Gunma (Japan); Nakano, Takashi [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma (Japan)] [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma (Japan); Yokota, Jun [Division of Multistep Carcinogenesis, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan)] [Division of Multistep Carcinogenesis, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan); Kohno, Takashi, E-mail: tkkohno@ncc.go.jp [Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan)] [Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan)

2012-11-01T23:59:59.000Z

325

A Systematic Stochastic Petri Net Based Methodology for Transformer Fault Diagnosis and Repair Actions  

Science Conference Proceedings (OSTI)

Transformer fault diagnosis and repair is a complex task that includes many possible types of faults and demands special trained personnel. Moreover, the minimization of the time needed for transformer fault diagnosis and repair is an important task ... Keywords: power system reliability, stochastic petri nets, transformer fault diagnosis

P. S. Georgilakis; J. A. Katsigiannis; K. P. Valavanis; A. T. Souflaris

2006-02-01T23:59:59.000Z

326

Manual of Bearing Failures and Repair in Power Plant Rotating Equipment  

Science Conference Proceedings (OSTI)

Bearing failures are a leading cause of unavailability for power plant rotating machinery, often resulting in prolonged forced outages and costly repairs. This manual, which assists utilities in identifying bearing failure modes and selecting remedial actions to prevent future failures, provides guidelines for repair techniques.

1991-08-08T23:59:59.000Z

327

Change-point detection in failure intensity: A case study with repairable artillery systems  

Science Conference Proceedings (OSTI)

Repairable systems can experience unexpected environmental changes over long operational periods. Such changes affect the incidence of failures, causing different system failure patterns before and after the changes. In this article, we propose an informational ... Keywords: Change-point, Homogeneous Poisson process, Modified information criterion, Repairable system, Schwarz information criterion, Statistical trend test

Suk Joo Bae; Byeong Min Mun; Kyung Yong Kim

2013-01-01T23:59:59.000Z

328

Repair Technology for Degraded Pressure Vessel and Heat Exchanger Shells: RRAC Task 91  

Science Conference Proceedings (OSTI)

The ability to repair pressure vessels and heat exchangers offers utilities significant cost savings compared to replacing these components. This is especially the case if outage time and loss of production are factored into the cost of replacement. This guide provides a review of various current and proposed repair methods that can be used for pressure vessel and heat exchanger applications.

2002-12-02T23:59:59.000Z

329

State-of-the-Art Weld Repair Technology for Rotating Components  

Science Conference Proceedings (OSTI)

Deregulation of the power industry, increased competition, enhanced environmental regulations, and aging or degraded equipment continue to place greater economic pressures on utilities. Weld repair of rotors and discs offers a viable means of extending the life of in-service rotors and discs. This report provides comprehensive repair guidelines for utilities.

1997-07-30T23:59:59.000Z

330

A generalized linear-quadratic model incorporating reciprocal time pattern of radiation damage repair  

Science Conference Proceedings (OSTI)

Purpose: It has been conventionally assumed that the repair rate for sublethal damage (SLD) remains constant during the entire radiation course. However, increasing evidence from animal studies suggest that this may not the case. Rather, it appears that the repair rate for radiation-induced SLD slows down with increasing time. Such a slowdown in repair would suggest that the exponential repair pattern would not necessarily accurately predict repair process. As a result, the purpose of this study was to investigate a new generalized linear-quadratic (LQ) model incorporating a repair pattern with reciprocal time. The new formulas were tested with published experimental data. Methods: The LQ model has been widely used in radiation therapy, and the parameter G in the surviving fraction represents the repair process of sublethal damage with T{sub r} as the repair half-time. When a reciprocal pattern of repair process was adopted, a closed form of G was derived analytically for arbitrary radiation schemes. The published animal data adopted to test the reciprocal formulas. Results: A generalized LQ model to describe the repair process in a reciprocal pattern was obtained. Subsequently, formulas for special cases were derived from this general form. The reciprocal model showed a better fit to the animal data than the exponential model, particularly for the ED50 data (reduced {chi}{sup 2}{sub min} of 2.0 vs 4.3, p = 0.11 vs 0.006), with the following gLQ parameters: {alpha}/{beta} = 2.6-4.8 Gy, T{sub r} = 3.2-3.9 h for rat feet skin, and {alpha}/{beta} = 0.9 Gy, T{sub r} = 1.1 h for rat spinal cord. Conclusions: These results of repair process following a reciprocal time suggest that the generalized LQ model incorporating the reciprocal time of sublethal damage repair shows a better fit than the exponential repair model. These formulas can be used to analyze the experimental and clinical data, where a slowing-down repair process appears during the course of radiation therapy.

Huang, Zhibin; Mayr, Nina A.; Lo, Simon S.; Wang, Jian Z.; Jia Guang; Yuh, William T. C.; Johnke, Roberta [Department of Radiation Oncology, East Carolina University, Greenville, North Carolina 27834 (United States); Department of Radiation Oncology, Ohio State University, Columbus, Ohio 43210 (United States); Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106 (United States); Department of Radiation Oncology, Ohio State University, Columbus, Ohio 43210 (United States); Department of Radiology, Ohio State University, Columbus, Ohio 43210 (United States); Department of Radiation Oncology, East Carolina University, Greenville, North Carolina, 27834 (United States)

2012-01-15T23:59:59.000Z

331

www.mdpi.com/journal/ijms Chromatin Dynamics during Nucleotide Excision Repair: Histones on the Move  

E-Print Network (OSTI)

Abstract: It has been a long-standing question how DNA damage repair proceeds in a nuclear environment where DNA is packaged into chromatin. Several decades of analysis combining in vitro and in vivo studies in various model organisms ranging from yeast to human have markedly increased our understanding of the mechanisms underlying chromatin disorganization upon damage detection and re-assembly after repair. Here, we review the methods that have been developed over the years to delineate chromatin alterations in response to DNA damage by focusing on the well-characterized Nucleotide Excision Repair (NER) pathway. We also highlight how these methods have provided key mechanistic insight into histone dynamics coupled to repair in mammals, raising new issues about the maintenance of chromatin integrity. In particular, we discuss how NER factors and central players in chromatin dynamics such as histone modifiers, nucleosome remodeling factors, and histone chaperones function to mobilize histones during repair.

Salomé Adam; Sophie E. Polo

2012-01-01T23:59:59.000Z

332

DNA Repair Protein Caught in the Act of Molecular Theft | Advanced...  

NLE Websites -- All DOE Office Websites (Extended Search)

A Molecular Fossil Ultrafast Imaging of Electron Waves in Graphene When Size Matters: Yttrium Oxide Breaking Down Under Pressure Breakthrough in Nanocrystals' Growth A Boring...

333

Health physics support for thermal shield repair at Connecticut Yankee  

Science Conference Proceedings (OSTI)

This article describes the radiation and safety controls used by Connecticut Yankee Atomic Power Company to support underwater repair work on the Haddam Neck Plant's core barrel thermal shield. The work was conducted by divers in the reactor cavity using remote tools and protected by a specially-constructed physical barrier that restricted their movements to a carefully defined and thoroughly surveyed area. A unique dosimetry test rig was used to determine the dose rate profiles within the work areas, and all underwater survey equipment was qualified against personnel dosimetric devices. Underwater operations were monitored and controlled by remote means (video surveillance and dosimetry telemetry), and health physics technicians were rotated through job coverage to avoid complacency and maximize training opportunities. A single, hot particle event occurred during one dive, but this was identified almost immediately and controlled to prevent excessive exposure to the diver.

Nevelos, W.F.; Gates, W.J. (Connecticut Yankee Atomic Power Co., East Hampton, CT (United States))

1988-10-01T23:59:59.000Z

334

Interfacial instability and DNA fork reversal by repair proteins  

E-Print Network (OSTI)

A repair protein like RecG moves the stalled replication fork in the direction from the zipped to the unzipped state of DNA. It is proposed here that a softening of the zipped-unzipped interface at the fork results in the front propagating towards the unzipped side. In this scenario, an ordinary helicase destabilizes the zipped state locally near the interface and the fork propagates towards the zipped side. The softening of the interface can be produced by the aromatic interaction, predicted from crystal structure, between RecG and the nascent broken base pairs at the Y-fork. A numerical analysis of the model also reveals the possibility of a stop and go type motion.

Somendra M. Bhattacharjee

2009-09-03T23:59:59.000Z

335

Removal of Dioxin Contamination for Gas Turbine Generator Set Repair  

SciTech Connect

Decontamination projects are typically undertaken in the interest of reducing disposal costs. This goal can be achieved because decontamination concentrates the contaminant into a smaller volume or changes its form so that a lower cost disposal technology becomes available. Less frequently, decontamination adds value back to the fouled structure or contaminated piece of equipment. This removal of dioxins from a gas turbine generator set is one of the latter cases. A multi-million dollar piece of equipment could have been destined for the scrap pile. Instead, an innovative, non-destructive decontamination technology, developed under EPA and DOE demonstration programs has was employed so that the set could repaired and put back into service. The TechXtractchemical decontamination technology reduced surface dioxin / furan concentrations from as high as 24,000 ng / m2 to less than 25 ng / m2 and below detection limits.

Fay, W. S.; Borah, R.E.

2003-02-25T23:59:59.000Z

336

Transgenic plants are sensitive bioindicators of nuclear pollution caused by the Chernobyl accident  

SciTech Connect

To evaluate the genetic consequences of radioactive contamination originating from the Nuclear reactor accident of Chernobyl on indigenous populations of plants and animals, it is essential to determine the rates of accumulating genetic changes in chronically irradiated populations. An increase in germline mutation rates in humans living close to the Chernobyl Nuclear Power Plant site, and a two- to tenfold increase in germline mutations in barn swallows breeding in Chernobyl have been reported. Little is known, however, about the effects of chronic irradiation on plant genomes. Ionizing radiation causes double-strand breaks in DNA, which are repaired via illegitimate or homologous recombination. The authors make use of Arabidopsis thaliana plants carrying a {beta}-glucuronidase marker gene as a recombination substrate to monitor genetic alterations in plant populations, which are caused by nuclear pollution of the environment around Chernobyl. A significant increase in somatic intrachromosomal recombination frequencies was observed at nuclear pollution levels from 0.1--900 Ci/km{sup 2}, consistent with an increase in chromosomal aberrations. This bioindicator may serve as a convenient and ethically acceptable alternative to animal systems.

Kovalchuk, I.; Kovalchuk, O. [Ivano-Frankivsk State Medical Academy (Ukraine)]|[Friedrich Miescher Inst., Basel (Switzerland); Arkhipov, A. [Chernobyl Scientific and Technical Center of International Research (Ukraine); Hohn, B. [Friedrich Miescher Inst., Basel (Switzerland)

1998-11-01T23:59:59.000Z

337

Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1  

SciTech Connect

Phosphorylated histone H2AX ({gamma}-H2AX) functions in the recruitment of DNA damage response proteins to DNA double-strand breaks (DSBs) and facilitates DSB repair. ATM also co-localizes with {gamma}-H2AX at DSB sites following its auto-phosphorylation. However, it is unclear whether {gamma}-H2AX has a role in activation of ATM-dependent cell cycle checkpoints. Here, we show that ATM as well as NBS1 is recruited to damaged-chromatin in a {gamma}-H2AX-dependent manner. Foci formation of phosphorylated ATM and ATM-dependent phosphorylation is repressed in H2AX-knockdown cells. Furthermore, anti-{gamma}-H2AX antibody co-immunoprecipitates an ATM-like protein kinase activity in vitro and recombinant H2AX increases in vitro kinase activity of ATM from un-irradiated cells. Moreover, H2AX-deficient cells exhibited a defect in ATM-dependent cell cycle checkpoints. Taken together, {gamma}-H2AX has important role for effective DSB-dependent activation of ATM-related damage responses via NBS1.

Kobayashi, Junya [Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto 606-8501 (Japan)], E-mail: jkobayashi@house.rbc.kyoto-u.ac.jp; Tauchi, Hiroshi [Department of Environmental Sciences, Ibaraki University, Ibaraki 310-8512 (Japan); Chen, Benjamin; Bruma, Sandeep [Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390-9187 (United States); Tashiro, Satoshi [Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553 (Japan); Matsuura, Shinya [Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553 (Japan); Tanimoto, Keiji [Department of Oral and Maxillofacial Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553 (Japan); Chen, David J. [Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390-9187 (United States); Komatsu, Kenshi [Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto 606-8501 (Japan)], E-mail: komatsu@house.rbc.kyoto-u.ac.jp

2009-03-20T23:59:59.000Z

338

ExpandplusCrystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA  

Science Conference Proceedings (OSTI)

Poly(ADP-ribose) polymerase-1 (PARP-1) has two homologous zinc finger domains, Zn1 and Zn2, that bind to a variety of DNA structures to stimulate poly(ADP-ribose) synthesis activity and to mediate PARP-1 interaction with chromatin. The structural basis for interaction with DNA is unknown, which limits our understanding of PARP-1 regulation and involvement in DNA repair and transcription. Here, we have determined crystal structures for the individual Zn1 and Zn2 domains in complex with a DNA double strand break, providing the first views of PARP-1 zinc fingers bound to DNA. The Zn1-DNA and Zn2-DNA structures establish a novel, bipartite mode of sequence-independent DNA interaction that engages a continuous region of the phosphodiester backbone and the hydrophobic faces of exposed nucleotide bases. Biochemical and cell biological analysis indicate that the Zn1 and Zn2 domains perform distinct functions. The Zn2 domain exhibits high binding affinity to DNA compared with the Zn1 domain. However, the Zn1 domain is essential for DNA-dependent PARP-1 activity in vitro and in vivo, whereas the Zn2 domain is not strictly required. Structural differences between the Zn1-DNA and Zn2-DNA complexes, combined with mutational and structural analysis, indicate that a specialized region of the Zn1 domain is re-configured through the hydrophobic interaction with exposed nucleotide bases to initiate PARP-1 activation.

M Langelier; J Planck; S Roy; J Pascal

2011-12-31T23:59:59.000Z

339

Breaking Down Enzymes' Role in Biofuel Production | U.S. DOE Office of  

Office of Science (SC) Website

Breaking Down Enzymes' Role in Biofuel Production Breaking Down Enzymes' Role in Biofuel Production Biological and Environmental Research (BER) BER Home About Research Facilities Science Highlights Searchable Archive of BER Highlights External link Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) News & Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3251 F: (301) 903-5051 E: sc.ber@science.doe.gov More Information » February 2013 Breaking Down Enzymes' Role in Biofuel Production Molecular structures provide insights into biomass deconstruction. Print Text Size: A A A Subscribe FeedbackShare Page Click to enlarge photo. Enlarge Photo

340

Record-breaking year for patents | Y-12 National Security Complex  

NLE Websites -- All DOE Office Websites (Extended Search)

Record-breaking year for ... Record-breaking year for ... Record-breaking year for patents Posted: February 11, 2013 - 2:57pm | Y-12 Report | Volume 9, Issue 2 | 2013 Fiscal 2012 was a fruitful year for innovative research and development at the Y-12 National Security Complex. Site inventors were issued an unprecedented 11 patents. Technologies and processes from many of Y-12's latest patents, like those from previous years, can extend beyond the Nuclear Security Enterprise into diverse areas of private industry. One technology, the measurement system Extrans, determines how much water permeates a material. At Y-12 this measuring method can protect moisture-sensitive material from corroding. In the food or pharmaceutical industry, however, Extrans could test product packaging to ensure that no

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Breaking a Cycle-Free Lifestyle for Earth Day | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Breaking a Cycle-Free Lifestyle for Earth Day Breaking a Cycle-Free Lifestyle for Earth Day Breaking a Cycle-Free Lifestyle for Earth Day April 12, 2012 - 12:07pm Addthis Elizabeth Spencer Communicator, National Renewable Energy Laboratory Earth Day is just around the corner! And while it might not be a major day for most people, I still think it's kind of fun. I think every special day is an excuse to do something you normally wouldn't! (And, speaking of little somethings, the Energy Efficiency and Renewable Energy website is going to have a small page up to commemorate Earth Day this year. Look for that next week.) This Earth Day, I'm buying a new bicycle! Now, before I start, let me get this out of the way: Bikes and I have not historically gotten along. When I was a young girl, I was so thrilled to

342

Breaking a Cycle-Free Lifestyle for Earth Day | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Breaking a Cycle-Free Lifestyle for Earth Day Breaking a Cycle-Free Lifestyle for Earth Day Breaking a Cycle-Free Lifestyle for Earth Day April 12, 2012 - 12:07pm Addthis Elizabeth Spencer Communicator, National Renewable Energy Laboratory Earth Day is just around the corner! And while it might not be a major day for most people, I still think it's kind of fun. I think every special day is an excuse to do something you normally wouldn't! (And, speaking of little somethings, the Energy Efficiency and Renewable Energy website is going to have a small page up to commemorate Earth Day this year. Look for that next week.) This Earth Day, I'm buying a new bicycle! Now, before I start, let me get this out of the way: Bikes and I have not historically gotten along. When I was a young girl, I was so thrilled to

343

DuPont Technology Breaks Away From Glass | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DuPont Technology Breaks Away From Glass DuPont Technology Breaks Away From Glass DuPont Technology Breaks Away From Glass April 22, 2010 - 4:20pm Addthis Delaware-based DuPont is working to develop ultra-thin moisture protective films for photovoltaic panels - so thin they're about 1,000 times thinner than a human hair. DuPont is working on new photovoltaic technology that will let manufacturers of copper indium gallium selenide, or CIGS, solar cells and organic light emitting diodes, or OLED, displays protect products with thin layers of ceramic and polymer material instead of glass. These ultra-thin protective films could help prevent deterioration from moisture. Because of their potential to reduce the cost of producing solar energy, "thin-film PV modules are projected to be the fastest-growing segment of

344

Largest Federally-Owned Wind Farm Breaks Ground at U.S. Weapons Facility |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Largest Federally-Owned Wind Farm Breaks Ground at U.S. Weapons Largest Federally-Owned Wind Farm Breaks Ground at U.S. Weapons Facility Largest Federally-Owned Wind Farm Breaks Ground at U.S. Weapons Facility August 13, 2013 - 10:54am Addthis News Media Contact (202) 586-4940 WASHINGTON - Building on President Obama's Climate Action Plan, which calls for steady, responsible steps to reduce carbon pollution, the Energy Department today broke ground on the nation's largest federally-owned wind project at the Pantex Plant in Amarillo, Texas. Once completed, this five-turbine 11.5 megawatt project will power more than 60 percent of the plant with clean, renewable wind energy and reduce carbon emissions by over 35,000 metric tons per year - equivalent to taking 7,200 cars off the road. The Pantex Plant is the primary site for the assembly, disassembly,

345

Breaking Up (Hydrogen) No Longer As Hard To Do | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Breaking Up (Hydrogen) No Longer As Hard To Do Breaking Up (Hydrogen) No Longer As Hard To Do Breaking Up (Hydrogen) No Longer As Hard To Do December 29, 2011 - 1:12pm Addthis Researchers at Argonne National Lab have recently developed a process to improve the efficiency of producing hydrogen to run cars such as this prototype, which was developed at the Oakridge National Lab. | Photo courtesy of Oak Ridge National Laboratory. Researchers at Argonne National Lab have recently developed a process to improve the efficiency of producing hydrogen to run cars such as this prototype, which was developed at the Oakridge National Lab. | Photo courtesy of Oak Ridge National Laboratory. Charles Rousseaux Charles Rousseaux Senior Writer, Office of Science What does this project do? Researchers have new insight into producing pure hydrogen -- a

346

DuPont Technology Breaks Away From Glass | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DuPont Technology Breaks Away From Glass DuPont Technology Breaks Away From Glass DuPont Technology Breaks Away From Glass April 22, 2010 - 4:20pm Addthis Delaware-based DuPont is working to develop ultra-thin moisture protective films for photovoltaic panels - so thin they're about 1,000 times thinner than a human hair. DuPont is working on new photovoltaic technology that will let manufacturers of copper indium gallium selenide, or CIGS, solar cells and organic light emitting diodes, or OLED, displays protect products with thin layers of ceramic and polymer material instead of glass. These ultra-thin protective films could help prevent deterioration from moisture. Because of their potential to reduce the cost of producing solar energy, "thin-film PV modules are projected to be the fastest-growing segment of

347

Breaking Up (Hydrogen) No Longer As Hard To Do | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Breaking Up (Hydrogen) No Longer As Hard To Do Breaking Up (Hydrogen) No Longer As Hard To Do Breaking Up (Hydrogen) No Longer As Hard To Do December 29, 2011 - 1:12pm Addthis Researchers at Argonne National Lab have recently developed a process to improve the efficiency of producing hydrogen to run cars such as this prototype, which was developed at the Oakridge National Lab. | Photo courtesy of Oak Ridge National Laboratory. Researchers at Argonne National Lab have recently developed a process to improve the efficiency of producing hydrogen to run cars such as this prototype, which was developed at the Oakridge National Lab. | Photo courtesy of Oak Ridge National Laboratory. Charles Rousseaux Charles Rousseaux Senior Writer, Office of Science What does this project do? Researchers have new insight into producing pure hydrogen -- a

348

Largest Federally-Owned Wind Farm Breaks Ground at U.S. Weapons Facility |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Largest Federally-Owned Wind Farm Breaks Ground at U.S. Weapons Largest Federally-Owned Wind Farm Breaks Ground at U.S. Weapons Facility Largest Federally-Owned Wind Farm Breaks Ground at U.S. Weapons Facility August 13, 2013 - 10:54am Addthis News Media Contact (202) 586-4940 WASHINGTON - Building on President Obama's Climate Action Plan, which calls for steady, responsible steps to reduce carbon pollution, the Energy Department today broke ground on the nation's largest federally-owned wind project at the Pantex Plant in Amarillo, Texas. Once completed, this five-turbine 11.5 megawatt project will power more than 60 percent of the plant with clean, renewable wind energy and reduce carbon emissions by over 35,000 metric tons per year - equivalent to taking 7,200 cars off the road. The Pantex Plant is the primary site for the assembly, disassembly,

349

Uncertainty in Electroweak Symmetry Breaking in Models With High Scale Supersymmetry Breaking and its Impact on Interpretations of Searches For Supersymmetric Particles  

E-Print Network (OSTI)

Some regions of parameter space of the minimal supersymmetric standard model (MSSM) with high scale supersymmetry breaking have extreme sensitivity of electroweak symmetry breaking (EWSB) to the top quark mass through renormalisation group evolution effects. This leads to uncertainties in the predictions which need to be taken into account in the interpretation of searches for supersymmetric particles in these regions. As an example, we provide estimates of the current uncertainties on the position in parameter space of the region which does not break electroweak symmetry in the constrained MSSM (CMSSM). The position of the boundary of EWSB can vary by up to 2 TeV in m_0 due to the uncertainties coming from the current measurement errors on the top quark mass and from higher order corrections. In this dangerous region, for fixed CMSSM parameters the neutralino lightest supersymmetric particle mass has an associated large uncertainty of order 100%. These uncertainties therefore have a profound effect on the interpretation of LHC supersymmetric particle searches in terms of the CMSSM. We also show how to ameliorate poor convergence of the iterative numerical algorithm that calculates the MSSM spectrum near the boundary of EWSB.

B. C. Allanach; M. A. Parker

2012-11-14T23:59:59.000Z

350

Development and validation of bonded composite doubler repairs for commercial aircraft.  

Science Conference Proceedings (OSTI)

A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack, impact, and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safely extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC), Boeing, and Federal Express completed a pilot program to validate and introduce composite doubler repair technology to the U.S. commercial aircraft industry. This project focused on repair of DC-10 fuselage structure and its primary goal was to demonstrate routine use of this repair technology using niche applications that streamline the design-to-installation process. As composite doubler repairs gradually appear in the commercial aircraft arena, successful flight operation data is being accumulated. These commercial aircraft repairs are not only demonstrating the engineering and economic advantages of composite doubler technology but they are also establishing the ability of commercial maintenance depots to safely adopt this repair technique. This report presents the array of engineering activities that were completed in order to make this technology available for widespread commercial aircraft use. Focused laboratory testing was conducted to compliment the field data and to address specific issues regarding damage tolerance and flaw growth in composite doubler repairs. Fatigue and strength tests were performed on a simulated wing repair using a substandard design and a flawed installation. In addition, the new Sol-Gel surface preparation technique was evaluated. Fatigue coupon tests produced Sol-Gel results that could be compared with a large performance database from conventional, riveted repairs. It was demonstrated that not only can composite doublers perform well in severe off-design conditions (low doubler stiffness and presence of defects in doubler installation) but that the Sol-Gel surface preparation technique is easier and quicker to carry out while still producing optimum bonding properties. Nondestructive inspection (NDI) methods were developed so that the potential for disbond and delamination growth could be monitored and crack growth mitigation could be quantified. The NDI methods were validated using full-scale test articles and the FedEx aircraft installations. It was demonstrated that specialized NDI techniques can detect flaws in composite doubler installations before they reach critical size. Probability of Detection studies were integrated into the FedEx training in order to quantify the ability of aircraft maintenance depots to properly monitor these repairs. In addition, Boeing Structural Repair and Nondestructive Testing Manuals were modified to include composite doubler repair and inspection procedures. This report presents the results from the FedEx Pilot Program that involved installation and surveillance of numerous repairs on operating aircraft. Results from critical NDI evaluations are reported in light of damage tolerance assessments for bonded composite doublers. This work has produced significant interest from airlines and aircraft manufacturers. The successful Pilot Program produced flight performance history to establish the durability of bonded composite patches as a permanent repair on commercial aircraft structures. This report discusses both the laboratory data and Pilot Program results from repair installations on operating aircraft to introduce composite doubler repairs into mainstream commercial aircraft use.

Roach, Dennis Patrick; Rackow, Kirk A.

2007-07-01T23:59:59.000Z

351

Effect of multiple repairs in girth welds of pipelines on the mechanical properties  

Science Conference Proceedings (OSTI)

This work presents the results of multiple weld repairs in the same area in seamless API X-52 microalloyed steel pipe. Four conditions of shielded metal arc welding repairs and one as-welded specimen of the girth weld were characterized to determine changes in the microstructure, grain size in the heat affected zone, and to evaluate their effect on the mechanical properties of the weld joints. The mechanical properties by means of tension tests, Charpy-V impact resistance and Vickers hardness of the welds were analyzed. The results indicate that significant changes are not generated in the microstructural constituents of the heat affected zone. Grain growth in the heat affected zone at the specimen mid-thickness with the number of repairs was observed. Tensile strength of the weld joints meets the requirement of the API 1104 standard even after the fourth weld repair. Significant reduction in Charpy-V impact resistance with the number of weld repairs was found when the notch location was in the intersection of the fusion line with the specimen mid-thickness. A significant increase in the Vickers hardness of the heat affected zone occurred after the first repair and a gradual decrease in the Vickers hardness occurred as the number of repairs increases.

Vega, O.E.; Hallen, J.M. [Departamento de Ingenieria Metalurgica, ESIQIE-IPN, Laboratorios Pesados de Metalurgia, UPALM, Zacatenco, C.P. 07738, Mexico D.F. (Mexico); Villagomez, A. [Construcciones Maritimas Mexicanas, CMM-PROTEXA, Av. Periferica s/n, Fracc. Lomas de Holche, C.P. 24120, Cd. del Carmen, Campeche (Mexico); Contreras, A. [Instituto Mexicano del Petroleo, Investigacion en Ductos, Corrosion y Materiales, Eje Central Lazaro Cardenas Norte 152 Col. San Bartolo Atepehuacan, C.P. 07730, Mexico D.F. (Mexico)], E-mail: acontrer@imp.mx

2008-10-15T23:59:59.000Z

352

Fabrication Flaw Density and Distribution In Repairs to Reactor Pressure Vessel and Piping Welds  

Science Conference Proceedings (OSTI)

The Pacific Northwest National Laboratory is developing a generalized fabrication flaw distribution for the population of nuclear reactor pressure vessels and for piping welds in U.S. operating reactors. The purpose of the generalized flaw distribution is to predict component-specific flaw densities. The estimates of fabrication flaws are intended for use in fracture mechanics structural integrity assessments. Structural integrity assessments, such as estimating the frequency of loss-of-coolant accidents, are performed by computer codes that require, as input, accurate estimates of flaw densities. Welds from four different reactor pressure vessels and a collection of archived pipes have been studied to develop empirical estimates of fabrication flaw densities. This report describes the fabrication flaw distribution and characterization in the repair weld metal of vessels and piping. This work indicates that large flaws occur in these repairs. These results show that repair flaws are complex in composition and sometimes include cracks on the ends of the repair cavities. Parametric analysis using an exponential fit is performed on the data. The relevance of construction records is established for describing fabrication processes and product forms. An analysis of these records shows there was a significant change in repair frequency over the years when these components were fabricated. A description of repair flaw morphology is provided with a discussion of fracture mechanics significance. Fabrication flaws in repairs are characterized using optimized-access, high-sensitivity nondestructive ultrasonic testing. Flaw characterizations are then validated by other nondestructive evaluation techniques and complemented by destructive testing.

GJ Schuster, FA Simonen, SR Doctor

2008-04-01T23:59:59.000Z

353

Q, Break-even and the n{tau{sub E}} Diagram for Transient Fusion Plasmas  

SciTech Connect

Q, break-even and the Lawson diagram are well defined and understood for steady-state fusion plasma conditions. Since many fusion experiments are transient, it is necessary to clarify the definitions for instantaneous Q values and break-even so that the Lawson diagram can be interpreted for transient plasma conditions. This discussion shows that there are two mathematically correct methods to describe the Lawson diagram for a transient plasma: the Lawson/TFTR method and the JET/JT-60 method. These methods are discussed in detail in this paper.

Dale M. Meade

1998-04-01T23:59:59.000Z

354

Multicritical Symmetry Breaking and Naturalness of Slow Nambu-Goldstone Bosons  

E-Print Network (OSTI)

We investigate spontaneous global symmetry breaking in the absence of Lorentz invariance, and study technical Naturalness of Nambu-Goldstone (NG) modes whose dispersion relation exhibits a hierarchy of multicritical phenomena with Lifshitz scaling and dynamical exponents $z>1$. For example, we find NG modes with a technically natural quadratic dispersion relation which do not break time reversal symmetry and are associated with a single broken symmetry generator, not a pair. The mechanism is protected by an enhanced `polynomial shift' symmetry in the free-field limit.

Tom Griffin; Kevin T. Grosvenor; Petr Horava; Ziqi Yan

2013-08-27T23:59:59.000Z

355

Wave breaking phenomenon of lower-hybrid oscillations induced by a background inhomogeneous magnetic field  

Science Conference Proceedings (OSTI)

In a fluid description, we study space-time evolution of lower hybrid modes in a cold quasi-neutral homogeneous plasma in presence of a background inhomogeneous magnetic field. Within a linear analysis, a dispersion relation with inhomogeneous magnetic field shows 'phase mixing' of such oscillations. A manifestation of 'phase mixing' is shown in 'mode coupling.' By using Lagrangian variables, an exact solution is presented in parametric form of this nonlinear time dependent problem. It is demonstrated that initially excited lower hybrid modes always break via phase mixing phenomenon in presence of an inhomogeneous magnetic field. Breaking of such oscillations is revealed by the appearance of spikes in the plasma density profile.

Maity, Chandan; Chakrabarti, Nikhil [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064 (India); Sengupta, Sudip [Institute for Plasma Research, Bhat, Gandhinagar 382428 (India)

2012-10-15T23:59:59.000Z

356

Evidence for layered symmetry breaking in SU(2) lattice gauge theory  

E-Print Network (OSTI)

Simulations of four-dimensional SU(2) lattice gauge theory are performed with partial axial gauge fixing trees spanning three of the four dimensions. The remaining SU(2) gauge symmetry, global in three directions and local in one, is found to break spontaneously at weak coupling, with the average fourth-dimension-pointing link in each perpendicular hyperplane as order parameter. The symmetry is restored at strong coupling. Symmetry breaking in each hyperplane appears to be independent, and occurs regardless of boundary conditions. The associated phase transition is likely coincident with the Polyakov loop transition.

Michael Grady

2004-09-29T23:59:59.000Z

357

The Messenger Sector of SUSY Flavour Models and Radiative Breaking of Flavour Universality  

E-Print Network (OSTI)

The flavour messenger sectors and their impact on the soft SUSY breaking terms are investigated in SUSY flavour models. In the case when the flavour scale M is below the SUSY breaking mediation scale M_S, the universality of soft terms, even if assumed at M_S, is radiatively broken. We estimate this effect in a broad class of models. In the CKM basis that effect gives flavour off-diagonal soft masses comparable to the tree-level estimate based on the flavour symmetry.

Calibbi, Lorenzo; Pokorski, Stefan; Ziegler, Robert

2012-01-01T23:59:59.000Z

358

Ultra-large distance modification of gravity from Lorentz symmetry breaking at the Planck scale  

E-Print Network (OSTI)

We present an extension of the Randall--Sundrum model in which, due to spontaneous Lorentz symmetry breaking, graviton mixes with bulk vector fields and becomes quasilocalized. The masses of KK modes comprising the four-dimensional graviton are naturally exponentially small. This allows to push the Lorentz breaking scale to as high as a few tenth of the Planck mass. The model does not contain ghosts or tachyons and does not exhibit the van Dam--Veltman--Zakharov discontinuity. The gravitational attraction between static point masses becomes gradually weaker with increasing of separation and gets replaced by repulsion (antigravity) at exponentially large distances.

D. S. Gorbunov; S. M. Sibiryakov

2005-06-08T23:59:59.000Z

359

From Decay to Complete Breaking: Pulling the Strings in SU(2) Yang-Mills Theory  

Science Conference Proceedings (OSTI)

We study (2Q+1) strings connecting two static charges Q in (2+1)D SU(2) Yang-Mills theory. While the fundamental (2) string between two charges Q=(1/2) is unbreakable, the adjoint (3) string connecting two charges Q=1 can break. When a (4) string is stretched beyond a critical length, it decays into a (2) string by gluon pair creation. When a (5) string is stretched, it first decays into a (3) string, which eventually breaks completely. The energy of the screened charges at the ends of a string is well described by a phenomenological constituent gluon model.

Pepe, M. [INFN, Istituto Nazionale di Fisica Nucleare, Sezione di Milano-Bicocca, Edificio U2, Piazza della Scienza 3, 20126 Milano (Italy); Wiese, U.-J. [Center for Research and Education in Fundamental Physics, Institute for Theoretical Physics, Bern University, Sidlerstrasse 5, 3012 Bern (Switzerland); Institute for Theoretical Physics, ETH Zuerich, Schafmattstrasse 32, CH-8093 Zuerich (Switzerland)

2009-05-15T23:59:59.000Z

360

Microsoft Word - SPR Emergency Pipeline Repair, 2013-2017 NEPA.docx  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Emergency Pipeline and Piping Repair, 2013-2017 Emergency Pipeline and Piping Repair, 2013-2017 Description: Subcontractor shall shall provide all labor, materials, equipment, supervision, transportation and services required to perform emergency repairs on the SPR system site piping (including underground fire protection systems and offsite pipelines). Subcontractor shall mobilize equipment to perform excavation, backfill, hydrostatic testing, welding and cutting, blasting, coating and painting of large and small diameter piping systems on the SPR facilities and offsite pipelines. Subcontractor shall also assist in emergency exercises by assemblying temporary piping spools and positioning pump skids and temporary supports. This NEPA document covers the period from 2013-2017.

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Epothilone B Confers Radiation Dose Enhancement in DAB2IP Gene Knock-Down Radioresistant Prostate Cancer Cells  

Science Conference Proceedings (OSTI)

Purpose: In metastatic prostate cancer, DOC-2/DAB2 interactive protein (DAB2IP) is often downregulated and has been reported as a possible prognostic marker to predict the risk of aggressive prostate cancer (PCa). Our preliminary results show that DAB2IP-deficient PCa cells are radioresistant. In this study, we investigated the anticancer drug Epothilone B (EpoB) for the modulation of radiosensitivity in DAB2IP-deficient human PCa cells. Methods and Materials: We used a stable DAB2IP-knock down human PCa cell line, PC3 shDAB2IP, treated with EpoB, ionizing radiation (IR), or the combined treatment of EpoB and IR. The modulation of radiosensitivity was determined by surviving fraction, cell cycle distribution, apoptosis, and DNA double-strand break (DSB) repair. For in vivo studies, the PC3shDAB2IP xenograft model was used in athymic nude mice. Results: Treatment with EpoB at IC{sub 50} dose (33.3 nM) increased cellular radiosensitivity in the DAB2IP-deficient cell line with a dose enhancement ratio of 2.36. EpoB delayed the DSB repair kinetics after IR and augmented the induction of apoptosis in irradiated cells after G{sub 2}/M arrest. Combined treatment of EpoB and radiation enhanced tumor growth delay with an enhancement factor of 1.2. Conclusions: We have demonstrated a significant radiation dose enhancement using EpoB in DAB2IP-deficient prostate cancer cells. This radiosensitization can be attributed to delayed DSB repair, prolonged G{sub 2} block, and increased apoptosis in cells entering the cell cycle after G{sub 2}/M arrest.

Kong Zhaolu [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Institute of Radiation Medicine, Fudan University, Shanghai (China); Raghavan, Pavithra [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Xie Daxing [Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Boike, Thomas [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Burma, Sandeep; Chen, David [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Simmons Comprehensive Cancer Center, 2201 Inwood Road, Dallas, TX 75390 (United States); Chakraborty, Arup [College of Pharmacy, University of Southern Nevada, Henderson, NV (United States); Hsieh, Jer-Tsong [Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Simmons Comprehensive Cancer Center, 2201 Inwood Road, Dallas, TX 75390 (United States); Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan (China); Saha, Debabrata, E-mail: debabrata.saha@utsouthwestern.ed [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Simmons Comprehensive Cancer Center, 2201 Inwood Road, Dallas, TX 75390 (United States)

2010-11-15T23:59:59.000Z

362

Benchmarking european airports based on a profitability envelope: a break-even analysis  

Science Conference Proceedings (OSTI)

In this paper a simplified benchmarking methodology is presented. This new approach is based on the computation of a discrete envelope over distributed data points. Financial and operational data from 139 European airports in 10 countries was collected ... Keywords: airport benchmarking, break-even analysis, profit maximization

Branko Bubalo

2012-09-01T23:59:59.000Z

363

NHMFL Breaks the 100 Tesla Barrier Gregory S. Boebinger, National High Magnetic Field Laboratory  

E-Print Network (OSTI)

NHMFL Breaks the 100 Tesla Barrier Gregory S. Boebinger, National High Magnetic Field Laboratory. 109no. 31 12404-12407 On March 22nd 2012, the NHMFL ­ Pulsed Field Facility broke the 100T tesla barrier, setting a world record of 100.75 tesla for a non-destructive magnet. By using advanced

Weston, Ken

364

On the Production of Aitken Nuclei from Breaking Waves and Their Role in the Atmosphere  

Science Conference Proceedings (OSTI)

A laboratory model of a breaking wave or whitecap was constructed, and the aerosol produced by it was investigated intensively. Submicron- and even Aitken-sized particles were produced: the presence of salt particles of mass <10?17 g(r<0.01 ?m) ...

Ramon J. Cipriano; Duncan C. Blanchard; Austin W. Hogan; G. Garland Lala

1983-02-01T23:59:59.000Z

365

Remote sensing of breaking wave phase speeds with application to non-linear depth inversions  

E-Print Network (OSTI)

Remote sensing of breaking wave phase speeds with application to non-linear depth inversions high-resolution remote sensing video and surface elevation records from fixed, in-situ wave gages. Wave phase speeds are extracted from the remote sensing data using a feature tracking technique, and local

Haller, Merrick

366

Calvert Cliffs 1 Reactor Vessel: Pressurized Thermal Shock Analysis for a Small Steam Line Break  

Science Conference Proceedings (OSTI)

Analysis of this Maryland reactor revealed a wide safety margin in its two-loop Combustion Engineering PWR pressure vessel for transients caused by small steam line breaks. The study employed a new method for analyzing pressurized thermal shock effects that combines several EPRI computer codes.

1984-11-01T23:59:59.000Z

367

Staying in the loop: structure and dynamics of Wikipedia's breaking news collaborations  

Science Conference Proceedings (OSTI)

Despite the fact that Wikipedia articles about current events are more popular and attract more contributions than typical articles, canonical studies of Wikipedia have only analyzed articles about pre-existing information. We expect the co-authoring ... Keywords: Wikipedia, breaking news, collaboration, high-tempo collaboration, multigraph, network analysis

Brian Keegan; Darren Gergle; Noshir Contractor

2012-08-01T23:59:59.000Z

368

The Monsoon over the Indian Ocean During Summer 1975. Part II: Break and Active Monsoons  

Science Conference Proceedings (OSTI)

In the second part of this paper we examine the active and break cycle of the monsoon during summer 1975. The time evolution of the flow over the Arabian Sea shocks that three main accelerations of the circulation occurred during the 1975 ...

Daniel Cadet

1983-01-01T23:59:59.000Z

369

Application of the Leak-Before-Break Approach to BWR Piping  

Science Conference Proceedings (OSTI)

By applying the leak-before-break approach in BWR safety evaluations, utilities can justify eliminating many pipe whip restraints and jet impingement shields. The report details a sample analysis of recirculation piping in a General Electric BWR and offers a procedure for ranking plant piping systems for analysis.

1987-01-07T23:59:59.000Z

370

On the perturbative generation of the higher-derivative Lorentz-breaking terms  

E-Print Network (OSTI)

In this paper, we describe the perturbative generation of the higher-derivative Lorentz-breaking terms for the gauge field, that is, the Myers-Pospelov term and the higher-derivative Carroll-Field-Jackiw term. These terms are explicitly calculated in the one-loop approximation and shown to be finite and ambiguous.

T. Mariz; J. R. Nascimento; A. Yu. Petrov

2011-11-01T23:59:59.000Z

371

Trends and breaks in per-capita carbon dioxide emissions, 1870-2028  

E-Print Network (OSTI)

We consider per-capita carbon dioxide emission trends in 16 early developed countries over the period 1870-2028. Using a multiple-break time series method we find more evidence for very early downturns in per-capita trends ...

Lanne, Markku

2003-01-01T23:59:59.000Z

372

Detection of Breaking Events in a Wind-Generated Wave Field  

Science Conference Proceedings (OSTI)

Measurements were made of the surface elevation of a fetch-limited wave field (fetch 7 km, wind speed about 6 m s?1). Good high-frequency response was attained by the use of a very thin, bare wire probe of diameter 0.13 mm. Breaking waves were ...

M. A. Weissman; S. S. Ataktürk; K. B. Katsaros

1984-10-01T23:59:59.000Z

373

A Signal-processing Scheme for Passive Acoustical Mapping of Breaking Surface Waves  

Science Conference Proceedings (OSTI)

An acoustical system is described with emphasis on its signal-processing scheme. The system consists of a small broadband hydrophone array of span 8.5 m and 5-kHz bandwidth, which is able to track individual breaking surface waves by passive ...

Li Ding; David M. Farmer

1992-08-01T23:59:59.000Z

374

Code Breaking with Quantum Computers 10 DCEMBRE 2013 15H30  

E-Print Network (OSTI)

CONFÃ?RENCE Code Breaking with Quantum Computers 10 DÃ?CEMBRE 2013 Ã? 15H30 auditorium COPL (salle POP, sprang up around this and other quantum principles, and quantum computers are its most prominent product to date. Quantum computers are not just billions of billions of times faster than your desk-top MAC

Laval, Université

375

A Protein that Repairs Damage to Cancer Cells | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

An X-ray Vortex on the Horizon? An X-ray Vortex on the Horizon? How Two Drops Become One Scientists Discover How Nanocluster Contaminants Increase Risk of Spreading Mobile RNA is Poised and Ready Glass Does a Double-Take Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Protein that Repairs Damage to Cancer Cells MAY 5, 2008 Bookmark and Share The ABH2-DNA complex. A team of University of Chicago scientists has shown how two proteins locate and repair damaged genetic material inside cells. Because one of the proteins detects and repairs DNA damage that may result from a certain type of cancer therapy, the researchers raised the possibility of designing a molecule that could interfere with the repair process, making cancer

376

In-Situ Repairs of Oil Industry Pipelines, Tanks and Vessels by ...  

Science Conference Proceedings (OSTI)

Abstract Scope, Metal arc welding under oil (MAW-UO) is a new, revolutionary process to repair a pipeline, tank or vessel by welding in case of flaws and ...

377

Plug repairs of marine glass fiber / vinyl ester laminates subjected to uniaxial tension  

E-Print Network (OSTI)

Glass fiber/vinyl ester composite laminates are currently being used and proposed for the hulls, bulkheads, and superstructures of large ships. This thesis examines the effectiveness of the repair of such laminates using ...

Michelis, Alexandros

2009-01-01T23:59:59.000Z

378

Maintenance and repair: a simulation model for field service with condition-based maintenance  

Science Conference Proceedings (OSTI)

In this paper, we consider field service in which service providers are responsible for maintaining equipment performance. To do so, preventive maintenance work is usually required in addition to repairs. Field service managers are often faced with the ...

Yiqing Lin; Arthur Hsu; Ravi Rajamani

2002-12-01T23:59:59.000Z

379

Tiny Terminators: New Micro-Robots Assemble, Repair Themselves and Are Surprisingly Strong  

Energy.gov (U.S. Department of Energy (DOE))

Tiny robots that can assemble and repair themselves? Watch a video of Argonne National Laboratory's micro-robots that easily perform tasks that can challenge other robots, including moving objects that are larger than themselves.

380

Modeling and centralization of strategic inventory for repairable and long lead-time spare parts  

E-Print Network (OSTI)

This thesis develops an optimal inventory model for repairable and long leadtime spare parts for an Engine overhaul business. In addition, it presents a business case for centralization of inventory. Pratt & Whitney purchased ...

Duncan, Tyeliah Elaine

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Review of Maintenance and Repair Times for Components in Technological Facilities  

SciTech Connect

This report is a compilation of some unique component repair time data and it also presents citations of more extensive reports where lists of repair times can be found. This collection of information should support analysts who seek to quantify maintainability and availability of high technology and nuclear energy production systems. While there are newer sources of repair time information, most, if not all, of the newer sources are proprietary and cannot be shared. This report offers data that, while older, is openly accessible and can serve as reasonable estimates of repair times, at least for initial studies. Some times were found for maintenance times in radiation environments, and some guidance for multiplicative factors to use to account for work in contamination areas.

L. C. Cadwallader

2012-11-01T23:59:59.000Z

382

Topical Report: Application of the Excavate and Weld Repair Process for Repair and Mitigation of Alloy 182 and 82 in PWRs  

Science Conference Proceedings (OSTI)

Weld overlay is a mature technology for the repair of PWR nozzle dissimilar metal butt welds that are susceptible to primary water stress corrosion cracking (PWSCC). While weld-overlay technology continues to serve the industry well, a viable alternative is desirable for large-bore nozzle welds (>24 inches outside diameter) to minimize the time required to perform the repair and to serve in cases in which significant physical interferences near the Alloy 82/182 dissimilar metal weld would make it difficu...

2010-12-20T23:59:59.000Z

383

Technical Repair Guidelines for the Limitorque Model SMB-00 Valve Actuator  

Science Conference Proceedings (OSTI)

This technical repair guideline (TRG) is the second in a series of documents devoted to comprehensive maintenance and repair of the motor-operated Limitorque SMB-00 valve actuator. The Limitorque SMB-00 valve actuator is mounted on a nonrotating rising stem valve and is applicable to other types of valves and installation arrangements. This report was written with the latest available information, however, changes to the actuator's design, parts availability, etc. may supersede this document but will not...

1995-06-30T23:59:59.000Z

384

RESTORING A DAMAGED 16-YEAR -OLD INSULATING POLYMER CONCRETE DIKE OVERLAY: REPAIR MATERIALS AND TECHNOLOGIES.  

Science Conference Proceedings (OSTI)

The objective of this program was to design and formulate organic polymer-based material systems suitable for repairing and restoring the overlay panels of insulating lightweight polymer concrete (ILPC) from the concrete floor and slope wall of a dike at KeySpan liquefied natural gas (LNG) facility in Greenpoint, Brooklyn, NY, just over sixteen years ago. It also included undertaking a small-scale field demonstration to ensure that the commercial repairing technologies were applicable to the designed and formulated materials.

SUGAMA,T.

2007-01-01T23:59:59.000Z

385

Welding and Repair Technology Center: Essential and Emergency Service Water System Issues  

Science Conference Proceedings (OSTI)

Because of the numerous ASME Code and Regulatory (Nuclear Regulatory Commission) documents addressing operability and repair of through-wall leakage in class 2 and 3 systems, inconsistencies exist in their interpretation and application. This report is intended to summarize and clarify the current Code and Regulatory requirements and provisions applicable to operability and repair of essential and emergency service water systems with leakage through the pressure boundary.

2010-10-29T23:59:59.000Z

386

A Numerical Study of Breaking Kelvin-Helmholtz Billows using a Reynolds-Stress Turbulence Closure Model  

Science Conference Proceedings (OSTI)

A two-dimensional numerical study of breaking Kelvin-Helmholtz billows is presented. The turbulent breaking process is modeled using second-order closure methods to describe the small-wale turbulence, while the large-scale billow itself is ...

R. I. Sykes; W. S. Lewellen

1982-07-01T23:59:59.000Z

387

LED Light Fixture Project FC1 Director's Conference Room: Life Cycle Cost and Break-even Analysis  

E-Print Network (OSTI)

LED Light Fixture Project ­ FC1 Director's Conference Room: Life Cycle Cost and Break-even Analysis. #12;LED Light Fixture Project ­ FC1 Director's Conference Room: Life Cycle Cost and Break,812 Maintenance Cost $620 $0 $97 $0 Life Cycle Cost $1,787 $1,693 $2,980 $2,980 #12;LED Light Fixture Project ­ FC

Hofmann, Hans A.

388

A Spar Buoy for High-Frequency Wave Measurements and Detection of Wave Breaking in the Open Ocean  

Science Conference Proceedings (OSTI)

Waves and wave breaking play a significant role in the air–sea exchanges of momentum, sea spray aerosols, and trace gases such as CO2, but few direct measurements of wave breaking have been obtained in the open ocean (far from the coast). This ...

Robin W. Pascal; Margaret J. Yelland; Meric A. Srokosz; Bengamin I. Moat; Edward M. Waugh; Daniel H. Comben; Alex G. Cansdale; Mark C. Hartman; David G. H. Coles; Ping Chang Hsueh; Timothy G. Leighton

2011-04-01T23:59:59.000Z

389

Break-Even Investment in a Wind Energy Conversion System for an Irrigated Farm on the Texas High Plains  

E-Print Network (OSTI)

The purpose of this study was to quantify the benefits of using a wind energy system for irrigation. The value of wind energy was estimated on both a static basis (where the annual value of wind power was assumed to be constant over the life of the machine) and on a temporal basis (where the annual value of wind power was estimated recursively). The model for static analysis contained two components which were applied consecutively. The first was a linear programming (LP) model for the High Plains region. Production activities were included which allowed both optimal and non-optimal timing of post-plant irrigations, giving the producer added flexibility in the employment of limiting water resources. The optimal irrigation schedule determined by the LP solution was used as input to the second component. A simulation model matched stochastically generated estimates of wind power availability with irrigation fuel requirements (derived from the profit maximizing irrigation schedule) by three-hour time periods throughout a year. For the temporal analysis, a Fortran subroutine was added to the LP model to operate the model recursively over the life of the wind system and to account for the annual decline of the aquifer. Both fixed and variable costs were included. The basic LP model was applied to develop the benchmark case (i.e., without wind power). The farm operation with wind power was analyzed by applying the LP model with the monthly expectations of wind-generated electricity added. Two wind machines were analyzed, with rate outputs of 40 to 60 kilowatts (KW). Each was applied to the Northern and Southern Texas High Plains over a range of land and water resource situations. Breakeven investment was estimated at discount rates of three, five and ten percent. Cropping patterns on the Southern High Plains were dominated by irrigated cotton and were insensitive to changes in crop or electricity prices. On the Northern High Plains, irrigated corn and grain sorghum were the major crops, with acreage reverting to dryland wheat at the higher electricity prices. The cropping patterns in this area were impacted heavily by labor restrictions. Consideration of wind power had little effect in determining optimal cropping patterns. When wind power was applied to an irrigated farm on a static basis, the set of crop prices applied had little effect on the annual value of a wind system. Value of wind power was increased, but by smaller proportions than associated increases in the price of electricity. Each machine size had a greater value when operated on the larger of the two applicable land units (100 acres for the 40 KW machine and 144 acres for the 60 KW system). The 60 KW system was also tested on the 100 acre unit but returned less per KW than the 40 KW system. Available wind power in the temporal analysis was less than in the static analysis, thus temporal estimates of wind system value should be regarded as conservative. On the Southern High Plains, break-even investment was decreased slightly from the static analysis. However, in some situations on the Northern High Plains, break-even investment increased. This indicates that the value of wind power could increase as the aquifer declines in some situations. Break-even investment increased by up to 80 percent when the price of electricity was increased by $.005 per KWH per year. The most significant effect of wind power was that it allowed the maintenance of irrigation levels which, without wind power, had been made uneconomical. These results indicate that, at least in the future when wind system costs decrease and stabilize, wind-assisted irrigation could be an economically viable alternative for Texas High Plains producers. The results are limited by the need for future research regarding the effect of irrigation timing on crop yield as well as some of the long-term characteristics of wind system operation, such as durability and the requirements and costs for system repairs and maintenance.

Hardin, D. C.; Lacewell, R. D.

1981-01-01T23:59:59.000Z

390

Live Cell Imaging and in situ analysis of cellular responses to DNA doublestrand  

NLE Websites -- All DOE Office Websites (Extended Search)

Live Cell Imaging and in situ analysis of cellular responses to DNA double- Live Cell Imaging and in situ analysis of cellular responses to DNA double- strand breaks in mammalian cells. David J. Chen Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas TX 75390 The integrity of the human genome is constantly threatened by internal as well as external factors with the propensity to cause DNA damage. Of the various types of DNA damage that can occur within the mammalian cell nucleus, the DNA double strand break (DSB) is perhaps the most dangerous. Estimates put the number of endogenous DSBs anywhere between 10-100 per nucleus per day. A direct link between DSBs and cancer has been surmised by researchers based upon the fact that many cancer-predisposition

391

Global methylation responses to low dose radiation exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

methylation responses to low dose radiation exposure methylation responses to low dose radiation exposure Pamela J Sykes, Michelle R Newman, Benjamin J Blyth and Rebecca J Ormsby Haematology and Genetic Pathology, Flinders University and Medical Centre, Flinders Centre for Cancer Prevention and Control, Bedford Park, Adelaide, South Australia 5042 Australia. (pam.sykes@flinders.edu.au). Our goal is to study the mechanisms involved in biological responses to low doses of radiation in vivo in the dose range that is relevant to population and occupational exposures. At high radiation doses, DNA double-strand breaks are considered the critical lesion underlying the initiation of radiation-induced carcinogenesis. However, at the very low radiation doses relevant for the general public, the induction of DNA double-strand breaks

392

Repair of UV damaged DNA, genes and proteins of yeast and human  

Science Conference Proceedings (OSTI)

Our objectives are to determine the molecular mechanism of the incision step of excision repair of ultraviolet (UV) light damaged DNA in eukaryotic organisms, using the yeast Saccharomyces cerevisiae as a model system, as well as studying the human homologs of yeast excision repair and postreplication repair proteins. In addition to its single-stranded DNA-dependent A TPase and DNA helicase activities, we have found that RAD3 protein also possesses DNA-RNA helicase activity, and that like RAD3, the Schizosaccharomyces pombe RAD3 homolog, rhp3{sup +}, is an essential gene. We have overexpressed the human RAD3 homolog, ERCC2, in yeast to facilitate its purification. The RAD10 protein was purified to homogeneity and shown to bind DNA. ERCC3y, the yeast homolog of the human ERCC-3/XP-B gene, has been sequenced and shown to be essential for viability. The Drosophila and human homologs of RAD6, required for postreplication repair and UV induced mutagenesis, were shown to complement the rad6 {Delta} mutation of yeast. Since defective DNA repair and enhanced neoplasia characterize several human genetic diseases, and repair proteins are highly conserved between yeast and man, a thorough understanding of the molecular mechanisms of DNA repir in yeast should provide a better understanding of the causes of carcinogenesis.

Prakash, L.

1991-04-01T23:59:59.000Z

393

Laser engineered net shaping (LENS) for the repair and modification of NWC metal components.  

DOE Green Energy (OSTI)

Laser Engineered Net Shaping{trademark} (LENS{reg_sign}) is a layer additive manufacturing process that creates fully dense metal components using a laser, metal powder, and a computer solid model. This process has previously been utilized in research settings to create metal components and new material alloys. The ''Qualification of LENS for the Repair and Modification of Metal NWC Components'' project team has completed a Technology Investment project to investigate the use of LENS for repair of high rigor components. The team submitted components from four NWC sites for repair or modification using the LENS process. These components were then evaluated for their compatibility to high rigor weapons applications. The repairs included hole filling, replacement of weld lips, addition of step joints, and repair of surface flaws and gouges. The parts were evaluated for mechanical properties, corrosion resistance, weldability, and hydrogen compatibility. This document is a record of the LENS processing of each of these component types and includes process parameters, build strategies, and lessons learned. Through this project, the LENS process was shown to successfully repair or modify metal NWC components.

Atwood, Clinton J.; Smugeresky, John E. (Sandia National Labs, Livermore,CA); Gill, David Dennis

2006-11-01T23:59:59.000Z

394

DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage  

Science Conference Proceedings (OSTI)

The post-meiotic phase of mouse spermatogenesis (spermiogenesis) is very sensitive to the genomic effects of environmental mutagens because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage. We hypothesized that repeated exposures to mutagens during this repair-deficient phase result in the accumulation of heritable genomic damage in mouse sperm that leads to chromosomal aberrations in zygotes after fertilization. We used a combination of single or fractionated exposures to diepoxybutane (DEB), a component of tobacco smoke, to investigate how differential DNA repair efficiencies during the three weeks of spermiogenesis affected the accumulation of DEB-induced heritable damage in early spermatids (21-15 days before fertilization, dbf), late spermatids (14-8 dbf) and sperm (7- 1 dbf). Analysis of chromosomalaberrations in zygotic metaphases using PAINT/DAPI showed that late spermatids and sperm are unable to repair DEB-induced DNA damage as demonstrated by significant increases (P<0.001) in the frequencies of zygotes with chromosomal aberrations. Comparisons between single and fractionated exposures suggested that the DNA repair-deficient window during late spermiogenesis may be less than two weeks in the mouse and that during this repair-deficient window there is accumulation of DNA damage in sperm. Finally, the dose-response study in sperm indicated a linear response for both single and repeated exposures. These findings show that the differential DNA repair capacity of post-meioitic male germ cells has a major impact on the risk of paternally transmitted heritable damage and suggest that chronic exposures that may occur in the weeks prior to fertilization because of occupational or lifestyle factors (i.e, smoking) can lead to an accumulation of genetic damage in sperm and result in heritable chromosomal aberrations of paternal origin.

Marchetti, Francesco; Marchetti, Francesco; Wryobek, Andrew J

2008-02-21T23:59:59.000Z

395

DNA Repair Decline During Mouse Spermiogenesis Results in the Accumulation of Heritable DNA Damage  

Science Conference Proceedings (OSTI)

The post-meiotic phase of mouse spermatogenesis (spermiogenesis) is very sensitive to the genomic effects of environmental mutagens because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage. We hypothesized that repeated exposures to mutagens during this repair-deficient phase result in the accumulation of heritable genomic damage in mouse sperm that leads to chromosomal aberrations in zygotes after fertilization. We used a combination of single or fractionated exposures to diepoxybutane (DEB), a component of tobacco smoke, to investigate how differential DNA repair efficiencies during the three weeks of spermiogenesis affected the accumulation of DEB-induced heritable damage in early spermatids (21-15 days before fertilization, dbf), late spermatids (14-8 dbf) and sperm (7-1 dbf). Analysis of chromosomal aberrations in zygotic metaphases using PAINT/DAPI showed that late spermatids and sperm are unable to repair DEB-induced DNA damage as demonstrated by significant increases (P<0.001) in the frequencies of zygotes with chromosomal aberrations. Comparisons between single and fractionated exposures suggested that the DNA repair-deficient window during late spermiogenesis may be less than two weeks in the mouse and that during this repair-deficient window there is accumulation of DNA damage in sperm. Finally, the dose-response study in sperm indicated a linear response for both single and repeated exposures. These findings show that the differential DNA repair capacity of post-meioitic male germ cells has a major impact on the risk of paternally transmitted heritable damage and suggest that chronic exposures that may occur in the weeks prior to fertilization because of occupational or lifestyle factors (i.e, smoking) can lead to an accumulation of genetic damage in sperm and result in heritable chromosomal aberrations of paternal origin.

Marchetti, Francesco; Marchetti, Francesco; Wyrobek, Andrew J.

2007-12-01T23:59:59.000Z

396

Breaking Good  

Science Conference Proceedings (OSTI)

This article tells in images and chunky captions the story of a study into the durability of four component glass. The information from this study is of interest to vitrification experts and geochemists.

Pierce, Eric M.; Shaw, Wendy J.; Plata, Charity; Manke, Kristin L.

2011-01-01T23:59:59.000Z

397

Modulational instability, wave breaking and formation of large scale dipoles in the atmosphere  

E-Print Network (OSTI)

In the present Letter we use the Direct Numerical Simulation (DNS) of the Navier-Stokes equation for a two-phase flow (water and air) to study the dynamics of the modulational instability of free surface waves and its contribution to the interaction between ocean and atmosphere. If the steepness of the initial wave is large enough, we observe a wave breaking and the formation of large scale dipole structures in the air. Because of the multiple steepening and breaking of the waves under unstable wave packets, a train of dipoles is released and propagate in the atmosphere at a height comparable with the wave length. The amount of energy dissipated by the breaker in water and air is considered and, contrary to expectations, we observe that the energy dissipation in air is larger than the one in the water. Possible consequences on the wave modelling and on the exchange of aerosols and gases between air and water are discussed.

Iafrati, A; Onorato, M

2012-01-01T23:59:59.000Z

398

Modulational instability, wave breaking and formation of large scale dipoles in the atmosphere  

E-Print Network (OSTI)

In the present Letter we use the Direct Numerical Simulation (DNS) of the Navier-Stokes equation for a two-phase flow (water and air) to study the dynamics of the modulational instability of free surface waves and its contribution to the interaction between ocean and atmosphere. If the steepness of the initial wave is large enough, we observe a wave breaking and the formation of large scale dipole structures in the air. Because of the multiple steepening and breaking of the waves under unstable wave packets, a train of dipoles is released and propagate in the atmosphere at a height comparable with the wave length. The amount of energy dissipated by the breaker in water and air is considered and, contrary to expectations, we observe that the energy dissipation in air is larger than the one in the water. Possible consequences on the wave modelling and on the exchange of aerosols and gases between air and water are discussed.

A. Iafrati; A. Babanin; M. Onorato

2012-08-27T23:59:59.000Z

399

Low-energy break in the spectrum of Galactic cosmic rays  

E-Print Network (OSTI)

Measurements of the low energy spectrum of Galactic Cosmic Rays (GCR) by detectors at or near the Earth are affected by Solar modulation. To overcome this difficulty, we consider nearby molecular clouds as GCR detectors outside the Solar system. Using gamma-ray observations of the clouds by the Fermi telescope we derive the spectrum of GCRs in the clouds from the observed gamma-ray emission spectrum. We find that the GCR spectrum has a low energy break with the spectral slope hardening by 1.1+/-0.3 at an energy of 9+/-3 GeV. Detection of a low-energy break enables a measurement of GCR energy density in the interstellar space 0.9+/-0.3 eV/cm3.

Neronov, A; Taylor, A M

2011-01-01T23:59:59.000Z

400

A Free Energy Landscape for Cage Breaking of Three Hard Disks  

E-Print Network (OSTI)

We investigate cage breaking in dense hard disk systems using a model of three Brownian disks confined within a circular corral. This system has a six-dimensional configuration space, but can be equivalently thought to explore a symmetric one-dimensional free energy landscape containing two energy minima separated by an energy barrier. The exact free energy landscape can be calculated as a function of system size. Results of simulations show the average time between cage breaking events follows an Arrhenius scaling when the energy barrier is large. We also discuss some of the consequences of using a one-dimensional representation to understand dynamics in a multi-dimensional space, such as diffusion acquiring spatial dependence and discontinuities in spatial derivatives of free energy.

Gary L. Hunter; Eric R. Weeks

2011-12-21T23:59:59.000Z

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401

Chiral symmetry breaking patterns in the U_L(n)xU_R(n) meson model  

E-Print Network (OSTI)

Chiral symmetry breaking patterns are investigated in the U_L(n)xU_R(n) meson model. It is shown that new classes of minima of the effective potential belonging to the center of the Lie algebra exist for arbitrary flavor number n. The true ground state of the system is searched nonperturbatively and although multiple local minima of the effective potential may exist, it is argued that in regions of the parameter space applicable for the strong interaction, strictly a U_L(n)xU_R(n)->U_V(n) spontaneous symmetry breaking is possible. The reason behind this is the existence of a discrete subset of axial symmetries, which connects various U_V(n) symmetric vacua of the theory. The results are in agreement with the Vafa-Witten theorem of QCD, illustrating that it remains valid, even without gauge fields, for an effective model of the strong interaction.

G. Fejos

2012-12-14T23:59:59.000Z

402

Gauge coupling unification in heterotic string models with gauge mediated supersymmetry breaking  

Science Conference Proceedings (OSTI)

We calculate the weak scale minimal supersymmetric standard model spectrum starting from a heterotic string theory compactified on an anisotropic orbifold. Supersymmetry breaking is mediated by vectorlike exotics that arise naturally in heterotic string theories. The messengers that mediate supersymmetry breaking come in incomplete grand unified theory (GUT) multiplets and give rise to nonuniversal gaugino masses at the GUT scale. Models with nonuniversal gaugino masses at the GUT scale have the attractive feature of allowing for precision gauge coupling unification at the GUT scale with negligible contributions from threshold corrections near the unification scale. The unique features of this minimally supersymmetric standard model spectrum are light gluinos and also large mass differences between the lightest and the next-to-lightest neutralinos and charginos which could lead to interesting signatures at the colliders.

Anandakrishnan, Archana; Raby, Stuart [Department of Physics, Ohio State University, 191, W. Woodruff Ave, Columbus, Ohio 43210 (United States)

2011-04-01T23:59:59.000Z

403

Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities  

NLE Websites -- All DOE Office Websites (Extended Search)

09 09 December 2009 Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities Paul Denholm, Robert M. Margolis, Sean Ong, and Billy Roberts National Renewable Energy Laboratory 1617 Cole Boulevard, Golden, Colorado 80401-3393 303-275-3000 * www.nrel.gov NREL is a national laboratory of the U.S. Department of Energy Office of Energy Efficiency and Renewable Energy Operated by the Alliance for Sustainable Energy, LLC Contract No. DE-AC36-08-GO28308 Technical Report NREL/TP-6A2-46909 December 2009 Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities Paul Denholm, Robert M. Margolis, Sean Ong, and Billy Roberts Prepared under Task No. PVD9.1210 NOTICE This report was prepared as an account of work sponsored by an agency of the United States government.

404

Gas Turbine Repair Guideline: GE 6FA/FA+e, Volume 19: GE MS6001 Model FA/FA+e  

Science Conference Proceedings (OSTI)

For more than a decade, the Electric Power Research Institute (EPRI) has been developing gas turbine hot section component repair and coating guidelines to assist utilities in the refurbishment of these critical and expensive parts. Utilities, generators, and repair vendors have used these guidelines to perform repairs on blades, turbine vanes, and combustion hardware. Guidelines now exist for a variety of conventional and advanced General Electric, Siemens/Westinghouse, Alstom, and Mitsubishi heavy ...

2013-12-11T23:59:59.000Z

405

On the breaking and restoration of symmetries within the nuclear energy density functional formalism  

E-Print Network (OSTI)

We review the notion of symmetry breaking and restoration within the frame of nuclear energy density functional methods. We focus on key differences between wave-function- and energy-functional-based methods. In particular, we point to difficulties encountered within the energy functional framework and discuss new potential constraints on the underlying energy density functional that could make the restoration of broken symmetries better formulated within such a formalism. We refer to Ref.~\\cite{duguet10a} for details.

T. Duguet; J. Sadoudi

2010-10-19T23:59:59.000Z

406

Definitive Identification of the Transition between Small- to Large-Scale Clustering for Lyman Break Galaxies  

E-Print Network (OSTI)

We report angular correlation function (ACF) of Lyman Break Galaxies (LBGs) with unprecedented statistical quality on the basis of 16,920 LBGs at z=4 detected in the 1 deg^2 sky of the Subaru/XMM-Newton Deep Field. The ACF significantly departs from a power law, and shows an excess on small scale. Particularly, the ACF of LBGs with i'ACF and number density of LBGs can be explained by the cold dark matter model.

M Ouchi; T. Hamana; K. Shimasaku; T. Yamada; M. Akiyama; N. Kashikawa; M. Yoshida; K. Aoki; M. Iye; T. Saito; T. Sasaki; C. Simpson; M. Yoshida

2005-08-02T23:59:59.000Z

407

Numerical evidence of breaking of vortex lines in an ideal fluid  

E-Print Network (OSTI)

Emergence of singularity of vorticity at a single point, not related to any symmetry of the initial distribution, has been demonstrated numerically for the first time. Behavior of the maximum of vorticity near the point of collapse closely follows the dependence 1/(t0-t), where t0 is the time of collapse. This agrees with the interpretation of collapse in an ideal incompressible fluid as of the process of vortex lines breaking.

Kuznetsov, E A; Zheligovsky, V A

2001-01-01T23:59:59.000Z

408

Gauge-Invariant Formalism with a Dirac-mode Expansion for Confinement and Chiral Symmetry Breaking  

E-Print Network (OSTI)

Using the eigen-mode of the QCD Dirac operator $\\Slash D=\\gamma^\\mu D^\\mu$, we develop a manifestly gauge-covariant expansion and projection of the QCD operators such as the Wilson loop and the Polyakov loop. With this method, we perform a direct analysis of the correlation between confinement and chiral symmetry breaking in lattice QCD Monte Carlo calculation on $6^4$ at $\\beta$=5.6. Even after removing the low-lying Dirac modes, which are responsible to chiral symmetry breaking, we find that the Wilson loop obeys the area law, and the slope parameter corresponding to the string tension or the confinement force is almost unchanged. We find also that the Polyakov loop remains to be almost zero even without the low-lying Dirac modes, which indicates the $Z_3$-unbroken confinement phase. These results indicate that one-to-one correspondence does not hold for between confinement and chiral symmetry breaking in QCD.

Shinya Gongyo; Takumi Iritani; Hideo Suganuma

2012-02-19T23:59:59.000Z

409

Simulation of a main steam line break with steam generator tube rupture using trace  

Science Conference Proceedings (OSTI)

A simulation of the OECD/NEA ROSA-2 Project Test 5 was made with the thermal-hydraulic code TRACE5. Test 5 performed in the Large Scale Test Facility (LSTF) reproduced a Main Steam Line Break (MSLB) with a Steam Generator Tube Rupture (SGTR) in a Pressurized Water Reactor (PWR). The result of these simultaneous breaks is a depressurization in the secondary and primary system in loop B because both systems are connected through the SGTR. Good approximation was obtained between TRACE5 results and experimental data. TRACE5 reproduces qualitatively the phenomena that occur in this transient: primary pressure falls after the break, stagnation of the pressure after the opening of the relief valve of the intact steam generator, the pressure falls after the two openings of the PORV and the recovery of the liquid level in the pressurizer after each closure of the PORV. Furthermore, a sensitivity analysis has been performed to know the effect of varying the High Pressure Injection (HPI) flow rate in both loops on the system pressures evolution. (authors)

Gallardo, S.; Querol, A.; Verdu, G. [Departamento de Ingenieria Quimica Y Nuclear, Universitat Politecnica de Valencia, Camino de Vera s/n, 46022, Valencia (Spain)

2012-07-01T23:59:59.000Z

410

Casimir scaling and string breaking in G{sub 2} gluodynamics  

Science Conference Proceedings (OSTI)

We study the potential energy between static charges in G{sub 2} gluodynamics in three and four dimensions. Our work is based on an efficient local hybrid Monte Carlo algorithm and a multilevel Luescher-Weisz algorithm with exponential error reduction to accurately measure expectation values of Wilson and Polyakov loops. Both in three and four dimensions we show that at intermediate scales the string tensions for charges in various G{sub 2} representations scale with the second order Casimir. In three dimensions Casimir scaling is confirmed within 4% for charges in representations of dimensions 7, 14, 27, 64, 77, 77{sup '}, 182, and 189 and in four dimensions within 5% for charges in representations of dimensions 7, 14, 27, and 64. In three dimensions we detect string breaking for charges in the two fundamental representations. The scale for string breaking agrees very well with the mass of the created pair of glue lumps. Close to the string breaking distance Casimir scaling between adjoint and defining representation is violated by 2.5%. The analytical prediction for the continuum string tension is confirmed for the defining representation in three dimensions.

Wellegehausen, Bjoern H.; Wipf, Andreas; Wozar, Christian [Theoretisch-Physikalisches Institut, Friedrich-Schiller-Universitaet Jena, Max-Wien-Platz 1, 07743 Jena (Germany)

2011-01-01T23:59:59.000Z

411

Development of a rapid design procedure for emergency repair of bridge columns using fiber-reinforced polymers  

E-Print Network (OSTI)

with success including wet layup, winding with wet tow orthen installed; whereas, wet layup based fabrication of FRPfor emergency repair. FRP wet layup also allows for ease of

Slater, Susan E.

2008-01-01T23:59:59.000Z

412

Effect of laser e LED radiations associated or not on dorsal cutaneous wound repair in a rodent model: histologic study.  

E-Print Network (OSTI)

??The aim of the present investigation was to evaluate histologically tissue repair on dorsal cutaneous wounds in a rodent model treated with Laser and/or LED,… (more)

Ana Paula Cavalcanti de Sousa

2008-01-01T23:59:59.000Z

413

A Parametric Study of a Large Break in Reactor Inlet Header of CANDU6 Reactors Using RELAP5 Code  

SciTech Connect

A large break loss of coolant accident in a CANDU can lead to degraded fuel cooling in a large number of fuel channels due to the apparition of a prolonged flow stagnation period in the downstream core pass. The paper presents a parametric study of a reactor inlet header break. The parametric survey includes: the size of the break, the choked flow model employed, the emergency core cooling (ECC) performance and the core nodalization. The study is performed with RELAP5/SCDAP mod 3.4 and the results are compared with the safety analysis results. (authors)

Prisecaru, Ilie; Dupleac, Daniel; Ghitescu, Petre [Power Plant Engineering Faculty, Politehnica Univ., 313 Splaiul Independentei, Bucharest (Romania); Biro, Lucian [National Commission for Nuclear Activities Control, 14 Libertatii Blvd., Bucharest (Romania)

2006-07-01T23:59:59.000Z

414

HANFORD SITE LOW EXPOSURE PIPELINE REPAIR USING A NON-METALLIC COMPOSITE SYSTEM  

Science Conference Proceedings (OSTI)

At the Department of Energy, Richland Operations (DOE-RL) Hanford site in eastern Washington, a 350 mm (14 inch) diameter high density polyethylene (HDPE) pump recirculation pipeline failed at a bonded joint adjacent to a radiologically and chemically contaminated groundwater storage basin. The responsible DOE-RL contractor, CH2MHill Plateau Remediation Company, applied a fiberglass reinforced plastic (composite) field repair system to the failed joint. The system was devised specifically for the HDPE pipe repair at the Hanford site, and had not been used on this type of plastic piping previously. This paper introduces the pipe failure scenario, describes the options considered for repair and discusses the ultimate resolution of the problem. The failed pipeline was successfully returned to service with minimal impact on waste water treatment plant operating capacity. Additionally, radiological and chemical exposures to facility personnel were maintained as low as reasonably achievable (ALARA). The repair is considered a success for the near term, and future monitoring will prove whether the repair can be considered for long term service and as a viable alternative for similar piping failures at the Hanford site.

HUTH RJ

2009-11-12T23:59:59.000Z

415

Enhancement of DNA repair capacity of mammalian cells by carcinogen treatment  

SciTech Connect

To determine whether DNA excision repair is enhanced in mammalian cells in response to DNA damage, as it is in bacteria as part of the SOS response, we used an expression vector-host cell reactivation assay to measure cellular DNA repair capacity. When UV-damaged chloramphenicol acetyltransferase (CAT) vector DNA was introduced into monkey cells (CV-1), the level of CAT activity was inversely related to the UV fluence due to inhibition of CAT gene expression by UV photoproducts. When CV-1 cells were treated with either UV radiation or mitomycin C, 24-48 h before transfection, CAT expression from the UV-irradiated plasmid was increased. This increase also occurred in a line of normal human cells, but not in repair-deficient human xeroderma pigmentosum cells. We confirmed that this increase in CAT expression was due to repair, and not to production of damage-free templates by recombination; the frequency of generation of supF+ recombinants after transfection with UV-irradiated pZ189 vectors carrying different point mutations in the supF gene did not significantly increase in carcinogen-treated CV-1 cells. From these results we conclude that carcinogen treatment enhances the excision-repair capacity of normal mammalian cells.

Protic, M.; Roilides, E.; Levine, A.S.; Dixon, K.

1988-07-01T23:59:59.000Z

416

Numerical simulation of three-dimensional breaking waves on a gravel slope using a two-phase flow Navier-Stokes model  

Science Conference Proceedings (OSTI)

Wave breaking is mainly a three-dimensional flow problem characterized by wave energy dissipation due to turbulence. The understanding of the wave breaking mechanism on a beach is essential in studying coastal processes. The complexity of the wave-induced ... Keywords: CFD, Porous medium, Two phase, VOF, Wave breaking

P. Higuera; M. Del Jesus; J. L. Lara; I. J. Losada; Y. Guanche; G. Barajas

2013-07-01T23:59:59.000Z

417

Microsoft PowerPoint - Bull Shoals U1 repair MSB edit 3.ppt  

NLE Websites -- All DOE Office Websites (Extended Search)

Bull Shoals Unit 1 161kV Bull Shoals Unit 1 161kV Switchyard Feeder Repair Bull Shoals Unit 1 161kV Bull Shoals Unit 1 161kV Switchyard Feeder Repair Switchyard Feeder Repair Mark Dixson Little Rock District US Army Corps US Army Corps of Engineers of Engineers ® ® One Corps Serving The Army and the Nation * Original Equipment - 52 years old. * Unit 1 Oil filled cable pothead failed and exploded on Sept 6 2006. * Resulting fire and fire suppression damaged oil insulated cable system * Minor damage to power plant. Background Background Background US Army Corps US Army Corps of Engineers of Engineers ® ® One Corps Serving The Army and the Nation * Transformer Unit 2 damaged and removed from service. * Cause of fire - Failure of Pothead stress cone assembly and build up of combustible gas * Power Plant lost all power and went in the

418

Emailed Comments of Elizabeth Chimento RE: Pepco Scheduled Line Repair Dec.  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Emailed Comments of Elizabeth Chimento RE: Pepco Scheduled Line Emailed Comments of Elizabeth Chimento RE: Pepco Scheduled Line Repair Dec. 1-20, 2006 Emailed Comments of Elizabeth Chimento RE: Pepco Scheduled Line Repair Dec. 1-20, 2006 Docket No. EO-05-01. Regarding the planned line outage, scheduled for Feb. 20 through Mar. 6, I am requesting that the residents near the plant be moved for the duration of the outage to protect their health. Emailed Comments of Elizabeth Chimento RE: Pepco Scheduled Line Repair Dec. 1-20, 2006 More Documents & Publications Letter from Elizabeth Chimento and Poul Hertel to the Federal Energy Regulatory Commission Re: District of Columbia Public Service Commission Emergency Petition and Complaint Docket No. EL05-145-000 Re: Potomac River Generating Station Department of Energy Case No.

419

Evaluation of bisphenol E cyanate ester for the resin-injection repair of advanced composites  

SciTech Connect

This thesis is a compilation of a general introduction and literature review that ties together the subsequent chapters which consist of two journal articles that have yet to be submitted for publication. The overall topic relates to the evaluation and application of a new class of cyanate ester resin with unique properties that lend it applicable to use as a resin for injection repair of high glass transition temperature polymer matrix composites. The first article (Chapter 2) details the evaluation and optimization of adhesive properties of this cyanate ester and alumina nanocomposites under different conditions. The second article (Chapter 3) describes the development and evaluation of an injection repair system for repairing delaminations in polymer matrix composites.

Wilber Yaote Lio

2009-12-19T23:59:59.000Z

420

Introduction of Break-Out Session 2 of the 2011 International PV Module Quality Assurance Forum(Presentation)  

Science Conference Proceedings (OSTI)

This presentation outlines the goals and specific tasks of break-out session 2 of the 2011 International PV Module Quality Assurance Forum, along with a review of accelerated stress tests used for photovoltaics (PV).

Wohlgemuth, J.; Kurtz, S.; Sample, T.; Yamamichi, M.

2011-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Influence of Mean Water Depth and a Subsurface Sandbar on the Onset and Strength of Wave Breaking  

Science Conference Proceedings (OSTI)

Wave breaking in the open ocean and coastal zones remains an intriguing yet incompletely understood process, with a strong observed association with wave groups. Recent numerical study of the evolution of fully nonlinear, two-dimensional deep ...

Jin-Bao Song; Michael L. Banner

2004-04-01T23:59:59.000Z

422

On Determining the Onset and Strength of Breaking for Deep Water Waves. Part I: Unforced Irrotational Wave Groups  

Science Conference Proceedings (OSTI)

Finding a robust threshold variable that determines the onset of breaking for deep water waves has been an elusive problem for many decades. Recent numerical studies of the unforced evolution of two-dimensional nonlinear wave trains have ...

Jin-Bao Song; Michael L. Banner

2002-09-01T23:59:59.000Z

423

Horizontal Scales of Variability over the Middle Atlantic Bight Shelf Break and Continental Rise from Finescale Observations  

Science Conference Proceedings (OSTI)

Observations with fine horizontal resolution are used to identify the horizontal scales of variability over the Middle Atlantic Bight (MAB) shelf break and continental rise. Spray gliders collected observations along two alongshelf transects over ...

Robert E. Todd; Glen G. Gawarkiewicz; W. Brechner Owens

2013-01-01T23:59:59.000Z

424

TITAN code development for application to a PWR steam line break accident : final report 1983-1984  

E-Print Network (OSTI)

Modification of the TITAN computer code which enables it to be applied to a PWR steam line break accident has been accomplished. The code now has the capability of simulating an asymmetric inlet coolant temperature transient ...

Tsai, Chon-Kwo

1984-01-01T23:59:59.000Z

425

Proteomic profiling revealed the functional networks associated with mitotic catastrophe of HepG2 hepatoma cells induced by 6-bromine-5-hydroxy-4-methoxybenzaldehyde  

Science Conference Proceedings (OSTI)

Mitotic catastrophe, a form of cell death resulting from abnormal mitosis, is a cytotoxic death pathway as well as an appealing mechanistic strategy for the development of anti-cancer drugs. In this study, 6-bromine-5-hydroxy-4-methoxybenzaldehyde was demonstrated to induce DNA double-strand break, multipolar spindles, sustain mitotic arrest and generate multinucleated cells, all of which indicate mitotic catastrophe, in human hepatoma HepG2 cells. We used proteomic profiling to identify the differentially expressed proteins underlying mitotic catastrophe. A total of 137 differentially expressed proteins (76 upregulated and 61 downregulated proteins) were identified. Some of the changed proteins have previously been associated with mitotic catastrophe, such as DNA-PKcs, FoxM1, RCC1, cyclin E, PLK1-pT210, 14-3-3{sigma} and HSP70. Multiple isoforms of 14-3-3, heat-shock proteins and tubulin were upregulated. Analysis of functional significance revealed that the 14-3-3-mediated signaling network was the most significantly enriched for the differentially expressed proteins. The modulated proteins were found to be involved in macromolecule complex assembly, cell death, cell cycle, chromatin remodeling and DNA repair, tubulin and cytoskeletal organization. These findings revealed the overall molecular events and functional signaling networks associated with spindle disruption and mitotic catastrophe. - Graphical abstract: Display Omitted Research highlights: > 6-bromoisovanillin induced spindle disruption and sustained mitotic arrest, consequently resulted in mitotic catastrophe. > Proteomic profiling identified 137 differentially expressed proteins associated mitotic catastrophe. > The 14-3-3-mediated signaling network was the most significantly enriched for the altered proteins. > The macromolecule complex assembly, cell cycle, chromatin remodeling and DNA repair, tubulin organization were also shown involved in mitotic catastrophe.

Zhang Bo [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Huang Bo [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); School of Public Health, University of South China, Hengyang, Hunan 421001 (China); Guan Hua; Zhang Shimeng; Xu Qinzhi [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); He Xingpeng [School of Public Health, University of South China, Hengyang, Hunan 421001 (China); Liu Xiaodan; Wang Yu; Shang Zengfu [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Zhou Pingkun, E-mail: zhoupk@nic.bmi.ac.cn [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); School of Public Health, University of South China, Hengyang, Hunan 421001 (China)

2011-05-01T23:59:59.000Z

426

Persistence of gamma-H2AX and 53BP1 foci in proliferating and nonproliferating human mammary epithelial cells after exposure to gamma-rays or iron ions  

Science Conference Proceedings (OSTI)

To investigate {gamma}-H2AX (phosphorylated histone H2AX) and 53BP1 (tumour protein 53 binding protein No. 1) foci formation and removal in proliferating and non-proliferating human mammary epithelial cells (HMEC) after exposure to sparsely and densely ionizing radiation under different cell culture conditions. HMEC cells were grown either as monolayers (2D) or in extracellular matrix to allow the formation of acinar structures in vitro (3D). Foci numbers were quantified by image analysis at various time points after exposure. Our results reveal that in non-proliferating cells under 2D and 3D cell culture conditions, iron-ion induced {gamma}-H2AX foci were still present at 72 h after exposure, although 53BP1 foci returned to control levels at 48 h. In contrast in proliferating HMEC, both {gamma}-H2AX and 53BP1 foci decreased to control levels during the 24-48 h time interval after irradiation under 2D conditions. Foci numbers decreased faster after {gamma}-ray irradiation and returned to control levels by 12 h regardless of marker, cell proliferation status, and cell culture condition. Conclusions: The disappearance of radiation induced {gamma}-H2AX and 53BP1 foci in HMEC have different dynamics that depend on radiation quality and proliferation status. Notably, the general patterns do not depend on the cell culture condition (2D versus 3D). We speculate that the persistent {gamma}-H2AX foci in iron-ion irradiated non-proliferating cells could be due to limited availability of double strand break (DSB) repair pathways in G0/G1-phase, or that repair of complex DSB requires replication or chromatin remodeling.

Groesser, Torsten; Chang, Hang; Fontenay, Gerald; Chen, James; Costes, Sylvain V.; Barcellos-Hoff, Mary Helen; Parvin, Bahram; Rydberg, Bjorn

2010-12-22T23:59:59.000Z

427

ATM-Dependent Hyper-Radiosensitivity in Mammalian Cells Irradiated by Heavy Ions  

SciTech Connect

Purpose: Low-dose hyper-radiosensitivity (HRS) and the later appearing radioresistance (termed induced radioresistance [IRR]) was mainly studied in low linear energy transfer (LET) radiation with survival observation. The aim of this study was to find out whether equivalent hypersensitivity occurred in high LET radiation, and the roles of ataxia telangiectasia mutated (ATM) kinase. Methods and Materials: Survival and mutation were measured by clonogenic assay and HPRT mutation assay. ATM Ser1981 activation was detected by Western blotting and immunofluorescent staining. Pretreatment of specific ATM inhibitor (10 {mu}M KU55933) and activator (20 {mu}g/mL chloroquine) before carbon radiation were adopted to explore the involvement of ATM. The roles of ATM were also investigated in its G2/M checkpoint function with histone H3 phosphorylation analysis and flow cytometric assay, and DNA double strand break (DSB) repair function measured using {gamma}-H2AX foci assay. Results: HRS/IRR was observed with survival and mutation in normal human skin fibroblast cells by carbon ions, while impaired in cells with intrinsic ATM deficiency or normal cells modified with specific ATM activator or inhibitor before irradiation. The dose-response pattern of ATM kinase activation was concordant with the transition from HRS to IRR. The ATM-dependent 'early' G2 checkpoint arrest and DNA DSB repair efficiency could explain the difference between HRS and IRR. Conclusions: These data demonstrate that the HRS/IRR by carbon ion radiation is an ATM-dependent phenomenon in the cellular response to DNA damage.

Xue Lian [School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou (China); Yu Dong [Tumor Endocrinology Project, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan)], E-mail: ydong@ncc.go.jp; Furusawa, Yoshiya [Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba-shi (Japan); Cao Jianping [School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou (China); Okayasu, Ryuichi [Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba-shi (Japan); Fan Saijun [School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou (China)

2009-09-01T23:59:59.000Z

428

AZD5438, an Inhibitor of Cdk1, 2, and 9, Enhances the Radiosensitivity of Non-Small Cell Lung Carcinoma Cells  

SciTech Connect

Purpose: Radiation therapy (RT) is one of the primary modalities for treatment of non-small cell lung cancer (NSCLC). However, due to the intrinsic radiation resistance of these tumors, many patients experience RT failure, which leads to considerable tumor progression including regional lymph node and distant metastasis. This preclinical study evaluated the efficacy of a new-generation cyclin-dependent kinase (Cdk) inhibitor, AZD5438, as a radiosensitizer in several NSCLC models that are specifically resistant to conventional fractionated RT. Methods and Materials: The combined effect of ionizing radiation and AZD5438, a highly specific inhibitor of Cdk1, 2, and 9, was determined in vitro by surviving fraction, cell cycle distribution, apoptosis, DNA double-strand break (DSB) repair, and homologous recombination (HR) assays in 3 NSCLC cell lines (A549, H1299, and H460). For in vivo studies, human xenograft animal models in athymic nude mice were used. Results: Treatment of NSCLC cells with AZD5438 significantly augmented cellular radiosensitivity (dose enhancement ratio rangeing from 1.4 to 1.75). The degree of radiosensitization by AZD5438 was greater in radioresistant cell lines (A549 and H1299). Radiosensitivity was enhanced specifically through inhibition of Cdk1, prolonged G{sub 2}-M arrest, inhibition of HR, delayed DNA DSB repair, and increased apoptosis. Combined treatment with AZD5438 and irradiation also enhanced tumor growth delay, with an enhancement factor ranging from 1.2-1.7. Conclusions: This study supports the evaluation of newer generation Cdk inhibitors, such as AZD5438, as potent radiosensitizers in NSCLC models, especially in tumors that demonstrate variable intrinsic radiation responses.

Raghavan, Pavithra; Tumati, Vasu; Yu Lan [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas (United States)] [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas (United States); Chan, Norman [Departments of Medical Biophysics and Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Ontario (Canada)] [Departments of Medical Biophysics and Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Ontario (Canada); Tomimatsu, Nozomi [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas (United States)] [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas (United States); Burma, Sandeep [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas (United States) [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas (United States); Simmons Comprehensive Cancer Center, Dallas, Texas (United States); Bristow, Robert G. [Departments of Medical Biophysics and Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Ontario (Canada)] [Departments of Medical Biophysics and Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Ontario (Canada); Saha, Debabrata, E-mail: debabrata.saha@utsouthwestern.edu [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas (United States) [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas (United States); Simmons Comprehensive Cancer Center, Dallas, Texas (United States)

2012-11-15T23:59:59.000Z

429

Break-Even Cost for Residential Solar Water Heating in the United States: Key Drivers and Sensitivities  

SciTech Connect

This paper examines the break-even cost for residential rooftop solar water heating (SWH) technology, defined as the point where the cost of the energy saved with a SWH system equals the cost of a conventional heating fuel purchased from the grid (either electricity or natural gas). We examine the break-even cost for the largest 1,000 electric and natural gas utilities serving residential customers in the United States as of 2008. Currently, the break-even cost of SWH in the United States varies by more than a factor of five for both electricity and natural gas, despite a much smaller variation in the amount of energy saved by the systems (a factor of approximately one and a half). The break-even price for natural gas is lower than that for electricity due to a lower fuel cost. We also consider the relationship between SWH price and solar fraction and examine the key drivers behind break-even costs. Overall, the key drivers of the break-even cost of SWH are a combination of fuel price, local incentives, and technical factors including the solar resource location, system size, and hot water draw.

Cassard, H.; Denholm, P.; Ong, S.

2011-02-01T23:59:59.000Z

430

DNA repair in cells sensitive and resistant to cis-diamminedichloroplatinum(II): Host cell reactivation of damaged plasmid DNA  

SciTech Connect

cis-Diamminedichloroplatinum(II) (cis-DDP) has a broad clinical application as an effective anticancer drug. However, development of resistance to the cytotoxic effects is a limiting factor. In an attempt to understand the mechanism of resistance, the authors have employed a host cell reactivation assay of DNA repair using a cis-DDP-damaged plasmid vector. The efficiency of DNA repair was assayed by measuring the activity of an enzyme coded for by the plasmid vector. The plasmid expression vector pRSV cat contains the bacterial gene coding for chloramphenicol acetyltransferase (CAT) in a configuration which permits expression in mammalian cells. The plasmid was transfected into repair-proficient and -deficient Chinese hamster ovary cells, and CAT activity was subsequently measured in cell lysates. In the repair-deficient cells, one cis-DDP adduct per cat gene was sufficient to eliminate expression. An equivalent inhibition of CAT expression in the repair-proficient cells did not occur until about 8 times the amount of damage was introduced into the plasmid. These results implicate DNA intrastrand cross-links as the lesions responsible for the inhibition of CAT expression. This assay was used to investigate the potential role of DNA repair in mediating cis-DDP resistance in murine leukemia L1210 cells. The assay readily detects the presence or absence of repair and confirms that these resistant L1210 cells have an enhanced capacity for repair of cis-DDP-induced intrastrand cross-links.

Sheibani, N.; Jennerwein, M.M.; Eastman, A. (Univ. of Nebraska Medical Center, Omaha (USA))

1989-04-04T23:59:59.000Z

431

MAINTENANCE SHOP The shop manager, Clint Steffan has over 25 years experience in Electronic design, test, and repair in  

E-Print Network (OSTI)

MAINTENANCE SHOP The shop manager, Clint Steffan has over 25 years experience in Electronic design the capability of repairing most electronic, mechanical and electro-mechanical equipment, including refrigeration source for parts instead of buying from equipment manufacturer. Repair/recharge small refrigeration

Lajeunesse, Marc J.

432

A Solution to the Strong CP Problem with Gauge-Mediated Supersymmetry Breaking  

E-Print Network (OSTI)

We demonstrate that a certain class of low scale supersymmetric ``Nelson-Barr'' type models can solve the strong and supersymmetric CP problems while at the same time generating sufficient weak CP violation in the $K^{0}-\\bar{K}^{0}$ system. In order to prevent one-loop corrections to $\\bar{\\theta}$ which violate bounds coming from the neutron electric dipole moment (EDM), one needs a scheme for the soft supersymmetry breaking parameters which can naturally give sufficient squark degeneracies and proportionality of trilinear soft supersymmetry-breaking parameters to Yukawa couplings. We show that a gauge-mediated supersymmetry breaking sector can provide the needed degeneracy and proportionality, though that proves to be a problem for generic Nelson-Barr models. The workable model we consider here has the Nelson-Barr mass texture enforced by a gauge symmetry; one also expects a new U(1) gauge superfield with mass in the TeV range. The resulting model is predictive. We predict a measureable neutron EDM and the existence of extra vector-like quark superfields which can be discovered at the LHC. Because the $3\\times 3$ Cabbibo-Kobayashi-Maskawa matrix is approximately real, the model also predicts a flat unitarity triangle and the absence of substantial CP violation in the $B$ system at future $B$ factories. We discuss the general issues pertaining to the construction of such a workable model and how they lead to the successful strategy. A detailed renormalization group study is then used to establish the feasibility of the model considered.

Otto C. W. Kong; Brian D. Wright

1998-02-03T23:59:59.000Z

433

Double Ended Guillotine Break in a Prismatic Block VHTR Lower Plenum Air Ingress Scenario  

E-Print Network (OSTI)

The double ended guillotine break leading to density-driven air ingress has been identified as a low probability yet high consequence event for Very High Temperature Reactor (VHTR). The lower plenum of the VHTR contains the core support structure and is composed of graphite. During an air ingress event, oxidation of the graphite structure under high temperature conditions in an oxygen containing environment could degrade the integrity of the core support structure. Following this large break, air from the reactor containment will begin to enter the lower plenum via two mechanisms: diffusion or density driven stratified flow. The large difference in time scales between the mechanisms leads to the need to perform high fidelity experimental studies to investigate the dominant the air ingress mechanism. A scaled test facility has been designed and built that allows the acquisition of velocity measurements during stratification after a pipe break. A non-intrusive optical measurement technique provides full-field velocity measurements profiles of the two species Particle Image Velocimetry (PIV). The data allow a more developed understanding of the fundamental flow features, the development of improved models, and possible mitigation strategies in such a scenario.Two brine-water experiments were conducted with different break locations. Flow fronts were analyzed and findings concluded that the flow has a constant speed through the pipe after the initial lock exchange. The time in which the flow enters the lower plenum is an important factor because it provides the window of opportunity for mitigation strategies in an actual reactor scenario. For both cases the flow of the heavier density liquid (simulating air ingress from the reactor containment) from the pipe enters the reactor vessel in under 6 seconds. The diffusion velocity and heavy flow front of the stratified flow layer were compared for the SF6/He gas case. It is seen that the diffusion plays less of a role as the transport mechanism in comparison to the density-driven stratified flow since the velocity of the diffusion is two orders of magnitude smaller than the velocity of the stratified flow mechanism. This is the reason for the need for density-driven stratified flow investigations following a LOCA. These investigations provided high-quality data for CFD validation in order for these models to depict the basic phenomena occurring in an air ingress scenario.

Hartley, Jessica

2011-08-01T23:59:59.000Z

434

BREAKING OF AXIAL AND REFLECTION SYMMETRIES IN SPONTANEOUS FISSION OF FERMIUM ISOTOPES  

SciTech Connect

The nuclear fission phenomenon is a magnificent example of a quantal collective motion during which the nucleus evolves in a multidimensional space representing shapes with different geometries. The triaxial degrees of freedom are usually important around the inner fission barrier, and reduce the fission barrier height by several MeV. Beyond the inner barrier, reflection-asymmetric shapes corresponding to asymmetric elongated fragments come into play. We discuss the interplay between different symmetry breaking mechanisms in the case of even-even fermium isotopes using the Skyrme HFB formalism.

Staszczak, A. [Maria Curie-Sklodowska University; Nazarewicz, Witold [ORNL; Baran, Andrzej K [ORNL

2011-01-01T23:59:59.000Z

435

Charge independence, charge symmetry breaking in the S-wave nucleon-nucleon interaction, and renormalization  

SciTech Connect

We study the interplay between charge symmetry breaking and renormalization in the NN system for S-waves. We find a set of universality relations which disentangle explicitly the known long distance dynamics from low energy parameters and extend them to the Coulomb case. We analyze within such an approach the One-Boson-Exchange potential and the theoretical conditions which allow to relate the proton-neutron, proton-proton and neutron-neutron scattering observables without the introduction of extra new parameters and providing good phenomenological success.

Alvaro Calle Cordon,Manuel Pavon Valderrama,Enrique Ruiz Arriola

2012-02-01T23:59:59.000Z

436

Comparative tests of isospin-symmetry-breaking corrections to superallowed 0+-to-0+ nuclear beta decay  

E-Print Network (OSTI)

We present a test with which to evaluate the calculated isospin-symmetry-breaking corrections to superallowed 0+-to-0+ nuclear beta decay. The test is based on the corrected experimental Ft values being required to satisfy conservation of the vector current (CVC). When applied to six sets of published calculations, the test demonstrates quantitatively that only one set -- the one based on the shell model with Saxon-Woods radial wave functions -- provides satisfactory agreement with CVC. This test can easily be applied to any sets of calculated correction terms that are produced in future.

Towner, I S

2010-01-01T23:59:59.000Z

437

Studying the Breaking Mechanism of Polymer-Based In-Situ Gelled Acids using Solid Breaker  

E-Print Network (OSTI)

In situ gelled acids that are based on polymers have been used in the field for several years as an acid diversion agent. These acids should not cause permanent formation damage, and should clean-up rapidly and completely when the well is put back on production. However, recent lab studies indicated that a significant amount of gel was retained inside the core even when the recommended breaker concentration was used. This gel significantly reduced the core permeability. Therefore, the objective of this study is to examine the working mechanisms of the solid breaker and the factors that affect the breaking time. The flowback of the spent acid and the core damage induced by it will also be assessed in detail. Viscosity and rheological experimental studies were conducted using polymer-based in situ gelled acids that used Zr as a crosslinker agent. To form the gel, this acid was neutralized using Pink Desert limestone to pH 3.5-4.The rheological properties of the gel were measured under different breaking conditions for 2 hr using HPHT rotational and oscillatory rheometers. Temperature (150 to 250 degrees F), shear rate (0.1 to 1000 s^-1), and breaker concentrations (0 to 32 lb/Mgal) were the main parameters that were investigated in this study. Experimental results showed that there is no need to add more than 16-ppg breaker concentration at 150 degrees F, while 4-ppg breaker concentration is enough at temperatures higher than 200 degrees F. A full breaking of these acids was obtained when the values of elastic modulus (G') were equalized with the viscose modules (G"). An HPHT filter press was used to simulate the flowback of the spent acid. Viscosity measurements of filtered fluids were used to determine the degree of gel degradation. Carbonate cores that had a 2.5 in. diameter and 0.25 in.thickness were used. Temperature (75 to 250 degrees F) and breaker concentrations (0 to 16 lb/Mgal) were the main parameters that were investigated in this study. Experimental results showed that there was always a gel left inside the rock, and such caused permeability reduction. Time needed to flowback the solution decreased by 50% when the temperature was increased from 150 to 200 degrees F, while it decreased by only 30% when the breaker concentration was doubled. At 150 degrees F, 16-ppg breaker concentration was recommended for breaking the gel. At higher temperatures (>150 degrees F), 8-ppg breaker concentration was enough to help degrade the gel.

Tian, Zhida

2012-08-01T23:59:59.000Z

438

The Effect of Price Expectations on Auto-Repair Price Quotes  

E-Print Network (OSTI)

We show that price expectations alter outcomes in a negotiated price environment. By experimentally manipulating the price expectations that consumers communicate to firms, we show that consumers ’ price expectations alter outcomes by directly changing firms ’ behavior. We implement a large-scale field experiment in which callers request price quotes from automotive repair shops. We find that repair shops quote higher prices if they know that callers ’ perception of the market price is high. We find that women are quoted higher prices than men when callers signal that they are uninformed about market prices. However, gender differences disappear when callers mention an expected price for the repair. Finally, we find that repair shops are more likely to offer In an environment in which prices customarily are negotiated, it can be difficult and time-consuming for consumers to gather enough information to create a good estimate of the market price. This phenomenon is common to many industries: buying a car entails lengthy negotiations in which dealers want to know about a consumer’s current vehicle, her financing preferences, the available

Meghan R. Busse; Florian Zettelmeyer

2012-01-01T23:59:59.000Z

439

Osteochondral defect repair using a novel tissue engineering approach: Sheep model study  

Science Conference Proceedings (OSTI)

Porous calcium polyphosphate (CPP) constructs of desired density were formed by sintering CPP powders. Articular cartilage was formed on these constructs in cell culture over an 8-week period with the resulting cartilage layer forming on the CPP surface ... Keywords: Articular cartilage repair, implants, in vitro and in vivo studies, osteochondral implants, porous calcium polyphosphate, tissue engineering, tissue ingrowth

R. M. Pilliar; R. A. Kandel; M. D. Grynpas; P. Zalzal; M. Hurtig

2007-01-01T23:59:59.000Z

440

Simulation and validation of repair welding and heat treatment of an alloy 718 plate  

Science Conference Proceedings (OSTI)

This paper describes simulation of repair welding and heat treatment together with measurements for validation. The possibility to replace global heat treatment with local using induction heating is evaluated with respect to obtained residual stresses. ... Keywords: Dislocation density based plasticity model, Finite element simulation, Heat treatment, Induction heating, Residual stress measurement

M. Fisk; A. LundbäCk

2012-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

A key-based coordination algorithm for dynamic readiness and repair service coordination  

Science Conference Proceedings (OSTI)

This paper describes an agent application for the coordination of air-craft repair, refit, refuel, and rearm teams in a dynamic setting. The paper also presents a new algorithm for dynamic distributed service team coordination and compares its performance ... Keywords: TAEMS, coordination, dynamic, intelligent agents, multi-agent systems, real-time, teams

Tom Wagner; Valerie Guralnik; John Phelps

2003-07-01T23:59:59.000Z

442

Evaluation of Hardware and Procedures for Astronaut Assembly and Repair of Large Precision Reflectors  

Science Conference Proceedings (OSTI)

A detailed procedure is presented that enables astronauts in extravehicular activity (EVA) to efficiently assemble and repair large (i.e., greater than 10m-diameter) segmented reflectors, supported by a truss, for space-based optical or radio-frequency ...

Lake Mark S.; Jr Walter L. Heard; Watson Judith J.; Collins Timothy J.

2000-08-01T23:59:59.000Z

443

Overview of NCHRP Design Guideline for EPS-Block Geofoam in Slope Stabilization and Repair  

E-Print Network (OSTI)

Manhattan College Bronx, New York 10471 Tel: (718) 826-7177 E-mail: john.horvath@manhattan.edu Dov and repair applications based on the results of National Cooperative Highway Research Program (NCHRP) Project was performed under NCHRP Project 24-11(01) and produced a design guideline for use of EPS blocks in stand

Horvath, John S.

444

A LYMAN BREAK GALAXY IN THE EPOCH OF REIONIZATION FROM HUBBLE SPACE TELESCOPE GRISM SPECTROSCOPY  

SciTech Connect

We present observations of a luminous galaxy at z = 6.573-the end of the reionization epoch-which has been spectroscopically confirmed twice. The first spectroscopic confirmation comes from slitless Hubble Space Telescope Advanced Camera for Surveys grism spectra from the PEARS survey (Probing Evolution And Reionization Spectroscopically), which show a dramatic continuum break in the spectrum at rest frame 1216 A. The second confirmation is done with Keck + DEIMOS. The continuum is not clearly detected with ground-based spectra, but high wavelength resolution enables the Ly{alpha} emission line profile to be determined. We compare the line profile to composite line profiles at z = 4.5. The Ly{alpha} line profile shows no signature of a damping wing attenuation, confirming that the intergalactic gas is ionized at z = 6.57. Spectra of Lyman breaks at yet higher redshifts will be possible using comparably deep observations with IR-sensitive grisms, even at redshifts where Ly{alpha} is too attenuated by the neutral intergalactic medium to be detectable using traditional spectroscopy from the ground.

Rhoads, James E.; Malhotra, Sangeeta; Cohen, Seth; Zheng Zhenya [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287 (United States); Stern, Daniel [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Dickinson, Mark [National Optical Astronomy Observatory, Tucson, AZ (United States); Pirzkal, Norbert; Grogin, Norman; Koekemoer, Anton; Peth, Michael A. [Space Telescope Science Institute, Baltimore, MD (United States); Spinrad, Hyron [University of California, Berkeley, CA (United States); Reddy, Naveen [University of California, Riverside, CA (United States); Hathi, Nimish [Observatories of the Carnegie Institution of Washington, Pasadena, CA (United States); Budavari, Tamas [Johns Hopkins University, Baltimore, MD (United States); Ferreras, Ignacio [Mullard Space Science Laboratory, University College London, Holmbury St Mary, Dorking, Surrey RH5 6NT (United Kingdom); Gardner, Jonathan P. [NASA Goddard Space Flight Center, Astrophysics Science Division, Observational Cosmology Laboratory, Code 665, Greenbelt, MD 20771 (United States); Gronwall, Caryl [Department of Astronomy and Astrophysics, and Institute for Gravitation and the Cosmos, The Pennsylvania State University, University Park, PA 16802 (United States); Haiman, Zoltan [Columbia University, New York, NY (United States); Kuemmel, Martin [Universitaets-Sternwarte Muenchen, Scheinerstr. 1, D-81679 Muenchen (Germany); Meurer, Gerhardt, E-mail: James.Rhoads@asu.edu [International Centre for Radio Astronomy Research, University of Western Australia, M468, 35 Stirling Highway, Crawley, WA 6009 (Australia); and others

2013-08-10T23:59:59.000Z

445

High-spin structures of 124-131Te: Competition of proton and neutron pair breakings  

E-Print Network (OSTI)

The 124-131Te nuclei have been produced as fission fragments in two fusion reactions induced by heavy-ions (12C + 238U at 90 MeV bombarding energy and 18O + 208Pb at 85 MeV) and studied with the Euroball array. Their high-spin level schemes have been extended to higher excitation energy from the triple gamma-ray coincidence data. The gamma-gamma angular correlations have been analyzed in order to assign spin and parity values to many observed states. Moreover the half-lives of isomeric states have been measured from the delayed coincidences between the fission-fragment detector SAPhIR and Euroball, as well as from the timing information of the Ge detectors. The behaviors of the yrast structures identified in the present work are first discussed in comparison with the general features known in the mass region, particularly the breakings of neutron pairs occupying the nuh11/2 orbit identified in the neighboring Sn nuclei. The experimental level schemes are then compared to shell-model calculations performed in this work. The analysis of the wave functions shows the effects of the proton-pair breaking along the yrast lines of the heavy Te isotopes.

A. Astier; M. -G. Porquet; Ts. Venkova; Ch. Theisen; G. Duchene; F. Azaiez; G. Barreau; D. Curien; I. Deloncle; O. Dorvaux; B. J. P. Gall; M. Houry; R. Lucas; N. Redon; M. Rousseau; O. Stezowski

2013-12-17T23:59:59.000Z

446

PT-symmetry breaking in complex nonlinear wave equations and their deformations  

E-Print Network (OSTI)

We investigate complex versions of the Korteweg-deVries equations and an Ito type nonlinear system with two coupled nonlinear fields. We systematically construct rational, trigonometric/hyperbolic, elliptic and soliton solutions for these models and focus in particular on physically feasible systems, that is those with real energies. The reality of the energy is usually attributed to different realisations of an antilinear symmetry, as for instance PT-symmetry. It is shown that the symmetry can be spontaneously broken in two alternative ways either by specific choices of the domain or by manipulating the parameters in the solutions of the model, thus leading to complex energies. Surprisingly the reality of the energies can be regained in some cases by a further breaking of the symmetry on the level of the Hamiltonian. In many examples some of the fixed points in the complex solution for the field undergo a Hopf bifurcation in the PT-symmetry breaking process. By employing several different variants of the symmetries we propose many classes of new invariant extensions of these models and study their properties. The reduction of some of these models yields complex quantum mechanical models previously studied.

Andrea Cavaglia; Andreas Fring; Bijan Bagchi

2011-03-09T23:59:59.000Z

447

Gauge invariant non-linear electrodynamics motivated by a spontaneous breaking of the Lorentz symmetry  

E-Print Network (OSTI)

We introduce a new version of non-linear electrodynamics which is produced by a spontaneous symmetry breaking of Lorentz invariance induced by the non-zero expectation value of the electromagnetic field strength. The symmetry breaking potential is argued to effectively arise from the integration of massive gauge bosons and fermions in an underlying fundamental theory. All possible choices of the vacuum lead only to the remaining invariant subgroups T(2) and HOM(2). We explore the plane wave solutions of the linearized sector of the model for an arbitrary vacuum. They present two types of dispersion relations. One corresponds to the case of the usual Maxwell electrodynamics with the standard polarization properties of the fields. The other dispersion relation involves anisotropies determined by the structure of the vacuum. The model is stable in the small Lorentz invariance violation approximation. We have embedded our model in the photon sector of the Standard Model Extension in order to set bounds for our parameters. The one-way anisotropic speed of light is calculated for a general vacuum and its isotropic component is strongly bounded by ${\\tilde \\delta c}/c alternative definition for the difference of the two-way speed of light in perpendicular directions $\\Delta c$, which is also strongly bounded by ${\\Delta c}/c energy of the model with the cosmological constant and propose a connection between the vacuum fields and the intergalactic magnetic fields.

Jorge Alfaro; Luis F. Urrutia

2009-12-16T23:59:59.000Z

448

PT-symmetry breaking in complex nonlinear wave equations and their deformations  

E-Print Network (OSTI)

We investigate complex versions of the Korteweg-deVries equations and an Ito type nonlinear system with two coupled nonlinear fields. We systematically construct rational, trigonometric/hyperbolic, elliptic and soliton solutions for these models and focus in particular on physically feasible systems, that is those with real energies. The reality of the energy is usually attributed to different realisations of an antilinear symmetry, as for instance PT-symmetry. It is shown that the symmetry can be spontaneously broken in two alternative ways either by specific choices of the domain or by manipulating the parameters in the solutions of the model, thus leading to complex energies. Surprisingly the reality of the energies can be regained in some cases by a further breaking of the symmetry on the level of the Hamiltonian. In many examples some of the fixed points in the complex solution for the field undergo a Hopf bifurcation in the PT-symmetry breaking process. By employing several different variants of the sym...

Cavaglia, Andrea; Bagchi, Bijan

2011-01-01T23:59:59.000Z

449

Vibration and Nonlinear Resonance in the Break-up of an Underwater Bubble  

E-Print Network (OSTI)

We use high-speed X-ray phase-contrast imaging, weakly nonlinear analysis and boundary integral simulations to characterize the final stage of underwater bubble break-up. The X-ray imaging study shows that an initial azimuthal perturbation to the shape of the bubble neck gives rise to oscillations that increasingly distort the cross-section shape. These oscillations terminate in a pinch-off where the bubble surface develops concave regions that contact similar to what occurs when two liquid drops coalesce. We also present a weakly nonlinear analysis that shows that this coalescence-like mode of pinch-off occurs when the initial shape oscillation interferes constructively with the higher harmonics it generates and thus reinforce each other's effects in bringing about bubble break-up. Finally we present numerical results that confirm the weakly nonlinear analysis scenario as well as provide insight into observed shape reversals. They demonstrate that when the oscillations interfere destructively, a qualitativel...

Lai, Lipeng; Fezzaa, Kamel; Zhang, Wendy W; Nagel, Sidney R

2013-01-01T23:59:59.000Z

450

Break-Even Cost for Residential Solar Water Heating in the United States: Key Drivers and Sensitivities  

NLE Websites -- All DOE Office Websites (Extended Search)

Break-even Cost for Residential Break-even Cost for Residential Solar Water Heating in the United States: Key Drivers and Sensitivities Hannah Cassard, Paul Denholm, and Sean Ong Technical Report NREL/TP-6A20-48986 February 2011 NREL is a national laboratory of the U.S. Department of Energy, Office of Energy Efficiency & Renewable Energy, operated by the Alliance for Sustainable Energy, LLC. National Renewable Energy Laboratory 1617 Cole Boulevard Golden, Colorado 80401 303-275-3000 * www.nrel.gov Contract No. DE-AC36-08GO28308 Break-even Cost for Residential Solar Water Heating in the United States: Key Drivers and Sensitivities Hannah Cassard, Paul Denholm, and Sean Ong Prepared under Task No. SS10.2110 Technical Report

451

On the breaking of a plasma wave in a thermal plasma. I. The structure of the density singularity  

SciTech Connect

The structure of the singularity that is formed in a relativistically large amplitude plasma wave close to the wave breaking limit is found by using a simple waterbag electron distribution function. The electron density distribution in the breaking wave has a typical 'peakon' form. The maximum value of the electric field in a thermal breaking plasma is obtained and compared to the cold plasma limit. The results of computer simulations for different initial electron distribution functions are in agreement with the theoretical conclusions. The after-wavebreak regime is then examined, and a semi-analytical model of the density evolution is constructed. Finally the results of two dimensional particle in cell simulations for different initial electron distribution functions are compared, and the role of thermal effects in enhancing particle injection is noted.

Bulanov, Sergei V.; Esirkepov, Timur Zh.; Kando, Masaki; Koga, James K.; Pirozhkov, Alexander S.; Nakamura, Tatsufumi [QuBS, Japan Atomic Energy Agency, 1-8-7 Umemidai, Kizugawa, Kyoto 619-0215 (Japan); Bulanov, Stepan S. [University of California, Berkeley, California 94720 (United States); Schroeder, Carl B.; Esarey, Eric [Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Califano, Francesco; Pegoraro, Francesco [Physics Department, University of Pisa, Pisa 56127 (Italy)

2012-11-15T23:59:59.000Z

452

Cellulose solventbased biomass pretreatment breaks highly ordered hydrogen bonds in cellulose fibers of switchgrass  

NLE Websites -- All DOE Office Websites (Extended Search)

Solvent-Based Solvent-Based Biomass Pretreatment Breaks Highly Ordered Hydrogen Bonds in Cellulose Fibers of Switchgrass Noppadon Sathitsuksanoh, 1,2 Zhiguang Zhu, 1 Sungsool Wi, 3 Y.-H. Percival Zhang 1,2,4 1 Biological Systems Engineering Department, Virginia Polytechnic Institute and State University (Virginia Tech), 210-A Seitz Hall, Blacksburg, Virginia 24061; telephone: 540-231-7414, fax: 540-231-3199; e-mail: ypzhang@vt.edu 2 Institute for Critical Technology and Applied Science (ICTAS), Virginia Polytechnic Institute and State University, Blacksburg, Virginia 3 Chemistry Department, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 4 DOE BioEnergy Science Center (BESC), Oak Ridge, Tennessee Received 25 June 2010; revision received 23 August 2010; accepted 4 October 2010 Published online 21 October 2010 in Wiley Online Library (wileyonlinelibrary.com).

453

Argonne Breaks Ground on $34.5M MX Research Facility  

NLE Websites -- All DOE Office Websites (Extended Search)

Stephenson Appointed ALD for Photon Sciences Stephenson Appointed ALD for Photon Sciences APS, Other DOE Labs Help Develop New Cancer Fighting Drug Paper on Fast Pharmaceuticals by APS Authors Featured in New Journal Art Scene Investigation: Picasso goes Nanotech Linda Young of APS Elected Vice Chair of DAMOP APS News Archives: 2012 | 2011 | 2010 | 2009 2008 | 2007 | 2006 | 2005 2004 | 2003 | 2002 | 2001 2000 Subscribe to APS News rss feed Argonne Breaks Ground on $34.5M MX Research Facility SEPTEMBER 15, 2011 Bookmark and Share Artist's rendering of the Advanced Protein Crystallization Facility (left in drawing). The Advanced Photon Source experiment hall is at right. The U.S. Department of Energy's (DOE's) Argonne National Laboratory broke ground on August 30, 2011, for a $34.5 million Advanced Protein

454

Single-Valued Hamiltonian via Legendre-Fenchel Transformation and Spontaneous Breaking of Time Translation Symmetry  

E-Print Network (OSTI)

Under conventional Legendre transformation, systems with a non-convex Lagrangian will result in a multi-valued Hamiltonian as a function of conjugate momentum. This causes problems such as non-unitary time evolution of quantum state and non-determined motion of classical particles, and is physically unacceptable. In this work, we propose a new construction of single-valued Hamiltonian by applying Legendre-Fenchel transformation, which is a mathematically rigorous generalization of conventional Legendre transformation, valid for non-convex Lagrangian systems, but not yet widely known to the physics community. With the new single-valued Hamiltonian, we study spontaneous breaking of time translation symmetry and derive its vacuum state.

Huan-Hang Chi; Hong-Jian He

2013-10-14T23:59:59.000Z

455

Wave-function entropy and dynamical-symmetry breaking in the interacting boson model  

E-Print Network (OSTI)

The degree of chaos in the Interacting Boson Model (IBM-1) is compared with what we call the "dynamical-symmetry content" of the system. The latter is represented by the information entropy of the eigenfunctions with respect to bases associated with dynamical symmetries of the IBM-1, and expresses thus the localization of actual eigenfunctions in these symmetry bases. The wave-function entropy is shown to be a sensitive tool for monitoring the processes of a single dynamical-symmetry breaking or transitions between two and more symmetries. For the IBM-1 hamiltonians studied here, the known features related to chaos, namely the dependence of chaotic measures on the hamiltonian parameters (position in the Casten triangle) and on the angular momentum, turn out to be correlated with the behaviour of the wave-function entropy. PACs 21.60.Fw; 05.45.+b

Pavel Cejnar; Jan Jolie

1998-02-25T23:59:59.000Z

456

Collider signatures of low scale supersymmetry breaking: A Snowmass 2013 White Paper  

E-Print Network (OSTI)

We consider the possibility that supersymmetry is broken at a low scale, within one order of magnitude above the TeV scale. In such a case, the degrees of freedom associated with the spontaneous breaking of supersymmetry, the goldstino fermion and its scalar superpartner (the sgoldstino), can have significant interactions with the Standard Model particles and their superpartners. We discuss some characteristic processes, involving the goldstino and the sgoldstino, and the collider signatures they give rise to. These signatures involve scalar resonances in the di-photon, di-jet, di-boson and di-tau channels, the possible relation between these resonances and deviations in the Higgs couplings as well as exotic Higgs decays in the monophoton+MET and the four photon channels.

Emilian Dudas; Christoffer Petersson; Riccardo Torre

2013-09-04T23:59:59.000Z

457

Non-universal, Non-anomalous U(1)' in a Model with Anomaly Mediated SUSY Breaking  

E-Print Network (OSTI)

We construct a Minimum Supersymmetry Standard Model expanded by a non-anomalous family (NAF) U(1)'_{NAF} gauge symmetry. All gauge anomalies are cancelled with no additional exotics other than the three right-handed neutrinos. The FI D-terms associated with the U(1)'_{NAF} symmetry lead to additional positive contributions to slepton squared masses. In a RG invariant way, this thus solves the tachyonic slepton mass problem in Anomaly Mediated Supersymmetry Breaking. In addition, the U(1)'_{NAF} symmetry naturally gives rise to the fermion mass hierarchy and mixing angles, and determines the mass spectrum of the sparticles. Our model also provides a counter example to the previous claim that the only U(1)' that can give rise to realistic fermion mass hierarchy and mixing pattern must be anomalous.

Mu-Chun Chen; Jinrui Huang

2010-11-29T23:59:59.000Z

458

Constraining Anomaly Mediated Supersymmetry Breaking Framework via Ongoing Muon g-2 Experiment at Brookhaven  

E-Print Network (OSTI)

The ongoing high precision E821 Brookhaven National Laboratory experiment on muon g-2 is promising to probe a theory involving supersymmetry. We have studied the constraints on the minimal Anomaly Mediated Supersymmetry Breaking (AMSB) model using the current data of muon g-2 from Brookhaven. A scenario of seeing no deviation from the Standard Model is also considered, within a $2\\sigma$ limit of the combined error from the Standard Model result and the Brookhaven predicted uncertainty level. The resulting constraint is found to be complementary to what one obtains from $b \\to s+ \\gamma$ bounds within the AMSB scenario, since only a definite sign of $\\mu$ is effectively probed via $b \\to s+ \\gamma$. A few relevant generic features of the model are also described for disallowed regions of parameter space.

Utpal Chattopadhyay; Dilip Kumar Ghosh; Sourov Roy

2000-06-05T23:59:59.000Z

459

Spatio-temporal evolution and breaking of double layers: A description using Lagrangian hydrodynamics  

Science Conference Proceedings (OSTI)

The nonlinear development and collapse (breaking) of double layers in the long scale length limit is well described by equations for the cold ion fluid with quasineutrality. It is shown that electron dynamics is responsible for giving an 'equation of state' with negative ratio of specific heats to this fluid. Introducing a transformation for the density variable, the governing equation for the transformed quantity in terms of Lagrange variables turns out exactly to be a linear partial differential equation. This equation has been analyzed in various limits of interest. Nonlinear development of double layers with a sinusoidal initial disturbance and collapse of double layers with an initial perturbation in the form of a density void are analytically investigated.

Kaw, Predhiman; Sengupta, Sudip; Singh Verma, Prabal [Institute for Plasma Research, Bhat, Gandhinagar 382 428 (India)

2012-10-15T23:59:59.000Z

460

Connected Green function approach to ground state symmetry breaking in $?^4_{1+1}$-theory  

E-Print Network (OSTI)

Using the cluster expansions for n-point Green functions we derive a closed set of dynamical equations of motion for connected equal-time Green functions by neglecting all connected functions higher than $4^{th}$ order for the $\\lambda \\Phi^4$-theory in $1+1$ dimensions. We apply the equations to the investigation of spontaneous ground state symmetry breaking, i.e. to the evaluation of the effective potential at temperature $T=0$. Within our momentum space discretization we obtain a second order phase transition (in agreement with the Simon-Griffith theorem) and a critical coupling of $\\lambda_{crit}/4m^2=2.446$ as compared to a first order phase transition and $\\lambda_{crit}/4m^2=2.568$ from the Gaussian effective potential approach.

J. M. Haeuser; W. Cassing; A. Peter; M. H. Thoma

1994-08-23T23:59:59.000Z

Note: This page contains sample records for the topic "double-strand break repair" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

The Green function and SU(3) breaking in K_{l3} decays  

E-Print Network (OSTI)

Using the 1/N_C expansion scheme and truncating the hadronic spectrum to the lowest-lying resonances, we match a meromorphic approximation to the Green function onto QCD by imposing the correct large-momentum falloff, both off-shell and on the relevant hadron mass shells. In this way we determine a number of chiral low-energy constants of O(p^6), in particular the ones governing SU(3) breaking in the K_{l3} vector form factor at zero momentum transfer. The main result of our matching procedure is that the known loop contributions largely dominate the corrections of O(p^6) to f_{+}(0). We discuss the implications of our final value f_{+}^{K^0 \\pi^-}(0)=0.984 \\pm 0.012 for the extraction of V_{us} from K_{l3} decays.

V. Cirigliano; G. Ecker; M. Eidemuller; R. Kaiser; A. Pich; J. Portoles

2005-03-11T23:59:59.000Z

462

Nikon Instruments Inc. | Resource Center -Research Papers -New insights into DNA repair http://www.nikoninstruments.com/Resource-Center/Research-Papers/New-insights-into-DNA-repair[4/10/2012 10:42:30 AM  

E-Print Network (OSTI)

, such as exposure to UV light, other forms of radiation, and certain environmental chemicals. DNA repair processes was performed using an Eclipse TE2000-U inverted microscope with a total internal reflection fluorescence (TIRF

Kowalczykowski, Stephen C.

463

Connections Between the TCR Proteins XPG and CSB, Repair of Oxidative DNA  

NLE Websites -- All DOE Office Websites (Extended Search)

Connections Between the TCR Proteins XPG and CSB, Repair of Oxidative DNA Connections Between the TCR Proteins XPG and CSB, Repair of Oxidative DNA Base Damage, and the Radio-Adaptive Response Helen Budworth, Brett Haltiwanger, Altaf Sarker, Torsten Grösser, Björn Rydberg, and Priscilla K. Cooper* Life Sciences Division, MailStop 74-157, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; *Corresponding author A key question that is central to accurately assessing human health risks from environmentally relevant low level (low dose, low dose rate) exposures to ionizing radiation is whether cellular responses measured at the higher doses for which there are strong epidemiological health data and the high doses commonly used in laboratory experiments extrapolate in a linear fashion to low doses. Recent data suggest that they may not. For example, low-dose hypersensitivity for

464

Low Dose Radiation Research Program: Genetic Control of Repair and Adaptive  

NLE Websites -- All DOE Office Websites (Extended Search)

Repair and Adaptive Responses to Low-level DNA Damage Repair and Adaptive Responses to Low-level DNA Damage James E. Haber Brandeis University Why This Project In order to fully understand mechanisms resulting in effects of low dose, whole system rather than cells must be examined. Although not identical to mammalian systems, simple systems usually have many similarities and give direction for further study of more complex systems. We use the budding yeast, Saccharomyces cerevisiae, as a model system because it is easy to manipulate and its genome is simple and well characterized. Project Goals Examine mechanisms and effects of low dose radiation response for: Genetic recombination mechanisms that lead to genomic instability Genetic factors that affect individual susceptibility to low-dose radiation The adaptive response

465

Standard practice for infrared flash thermography of composite panels and repair patches used in aerospace applications  

E-Print Network (OSTI)

1.1 This practice describes a procedure for detecting subsurface flaws in composite panels and repair patches using Flash Thermography (FT), in which an infrared (IR) camera is used to detect anomalous cooling behavior of a sample surface after it has been heated with a spatially uniform light pulse from a flash lamp array. 1.2 This practice describes established FT test methods that are currently used by industry, and have demonstrated utility in quality assurance of composite structures during post-manufacturing and in-service examinations. 1.3 This practice has utility for testing of polymer composite panels and repair patches containing, but not limited to, bismaleimide, epoxy, phenolic, poly(amide imide), polybenzimidazole, polyester (thermosetting and thermoplastic), poly(ether ether ketone), poly(ether imide), polyimide (thermosetting and thermoplastic), poly(phenylene sulfide), or polysulfone matrices; and alumina, aramid, boron, carbon, glass, quartz, or silicon carbide fibers. Typical as-fabricate...

American Society for Testing and Materials. Philadelphia

2007-01-01T23:59:59.000Z

466

Weld Repair of a Stamped Pressure Vessel in a Radiologically Controlled Zone  

Science Conference Proceedings (OSTI)

In September 2012 an ASME B&PVC Section VIII stamped pressure vessel located at the DOE Hanford Site Effluent Treatment Facility (ETF) developed a through-wall leak. The vessel, a steam/brine heat exchanger, operated in a radiologically controlled zone (by the CH2MHill PRC or CHPRC), had been in service for approximately 17 years. The heat exchanger is part of a single train evaporator process and its failure caused the entire system to be shut down, significantly impacting facility operations. This paper describes the activities associated with failure characterization, technical decision making/planning for repair by welding, logistical challenges associated with performing work in a radiologically controlled zone, performing the repair, and administrative considerations related to ASME code requirements.

Cannell, Gary L. [Fluor Enterprises, Inc.; Huth, Ralph J. [CH2MHill Plateau Remediation Company; Hallum, Randall T. [Fluor Government Group

2013-08-26T23:59:59.000Z

467

Subterranean barriers, methods, and apparatuses for forming, inspecting, selectively heating, and repairing same  

DOE Patents (OSTI)

A subterranean barrier and method for forming same are disclosed, the barrier including a plurality of casing strings wherein at leas