Sample records for double-strand break repair

  1. Quantitative measurement and modeling of the DNA damage signaling network : DNA double-strand breaks

    E-Print Network [OSTI]

    Tentner, Andrea R. (Andrea Ruth)

    2009-01-01T23:59:59.000Z

    DNA double-strand breaks (DSB) are one of the major mediators of chemotherapy-induced cytotoxicity in tumors. Cells that experience DNA damage can initiate a DNA damage-mediated cell-cycle arrest, attempt to repair the ...

  2. The Impact of Individual In Vivo Repair of DNA Double-Strand Breaks on Oral Mucositis in Adjuvant Radiotherapy of Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Fleckenstein, Jochen, E-mail: rajfle@uks.eu [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Kuehne, Martin; Seegmueller, Katharina; Derschang, Sarah; Melchior, Patrick [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Graeber, Stefan [Institute for Medical Biometry, Epidemiology und Medical Informatics (IMBEI), Saarland University Medical School, Homburg (Germany); Fricke, Andreas; Ruebe, Claudia E.; Ruebe, Christian [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany)

    2011-12-01T23:59:59.000Z

    Purpose: To evaluate the impact of individual in vivo DNA double-strand break (DSB) repair capacity on the incidence of severe oral mucositis in patients with head-and-neck cancer undergoing adjuvant radiotherapy (RT) or radiochemotherapy (RCT). Patients and Methods: Thirty-one patients with resected head-and-neck cancer undergoing adjuvant RT or RCT were examined. Patients underwent RT of the primary tumor site and locoregional lymph nodes with a total dose of 60-66 Gy (single dose 2 Gy, five fractions per week). Chemotherapy consisted of two cycles of cisplatin and 5-fluorouracil. To assess DSB repair, {gamma}-H2AX foci in blood lymphocytes were quantified before and 0.5 h, 2.5 h, 5 h, and 24 h after in vivo radiation exposure (the first fraction of RT). World Health Organization scores for oral mucositis were documented weekly and correlated with DSB repair. Results: Sixteen patients received RT alone; 15 patients received RCT. In patients who developed Grade {>=} 3 mucositis (n = 18) the amount of unrepaired DSBs 24 h after radiation exposure and DSB repair half-times did not differ significantly from patients with Grade {<=}2 mucositis (n = 13). Patients with a proportion of unrepaired DSBs after 24 h higher than the mean value + one standard deviation had an increased incidence of severe oral mucositis. Conclusions: Evaluation of in vivo DSB repair by determination of {gamma}-H2AX foci loss is feasible in clinical practice and allows identification of patients with impaired DSB repair. The incidence of oral mucositis is not closely correlated with DSB repair under the evaluated conditions.

  3. Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions

    SciTech Connect (OSTI)

    Zafar, Faria; Seidler, Sara B.; Kronenberg, Amy; Schild, David; Wiese, Claudia

    2010-06-29T23:59:59.000Z

    To test the contribution of homologous recombinational repair (HRR) in repairing DNA damaged sites induced by high-energy iron ions, we used: (1) HRR-deficient rodent cells carrying a deletion in the RAD51D gene and (2) syngeneic human cells impaired for HRR by RAD51D or RAD51 knockdown using RNA interference. We show that in response to iron ions, HRR contributes to cell survival in rodent cells, and that HRR-deficiency abrogates RAD51 foci formation. Complementation of the HRR defect by human RAD51D rescues both enhanced cytotoxicity and RAD51 foci formation. For human cells irradiated with iron ions, cell survival is decreased, and, in p53 mutant cells, the levels of mutagenesis are increased when HRR is impaired. Human cells synchronized in S phase exhibit more pronounced resistance to iron ions as compared with cells in G1 phase, and this increase in radioresistance is diminished by RAD51 knockdown. These results implicate a role for RAD51-mediated DNA repair (i.e. HRR) in removing a fraction of clustered lesions induced by charged particle irradiation. Our results are the first to directly show the requirement for an intact HRR pathway in human cells in ensuring DNA repair and cell survival in response to high-energy high LET radiation.

  4. Processing of 3'-Phosphoglycolate-Terminated DNA Double-StrandBreaks by Artemis Nuclease

    SciTech Connect (OSTI)

    Povrik, Lawrence F.; Zhou, Tong; Zhou, Ruizhe; Cowan, Morton J.; Yannone, Steven M.

    2005-10-01T23:59:59.000Z

    The Artemis nuclease is required for V(D)J recombination and for repair of an as yet undefined subset of radiation-induced DNA double-strand breaks. To assess the possibility that Artemis functions on oxidatively modified double-strand break termini, its activity toward model DNA substrates, bearing either 3{prime}-hydroxyl or 3{prime}-phosphoglycolate moieties, was examined. A 3{prime}-phosphoglycolate had little effect on Artemis-mediated trimming of long 3{prime} overhangs (>9 nucleotides), which were efficiently trimmed to 4-5 nucleotides. However, 3{prime}-phosphoglycolates on overhangs of 4-5 bases promoted selective Artemis-mediated trimming of a single 3{prime}-terminal nucleotide, while at least 2 nucleotides were trimmed from identical hydroxyl-terminated substrates. Artemis also efficiently removed a single nucleotide from a phosphoglycolate-terminated 3-base 3{prime} overhang, while leaving an analogous hydroxyl-terminated overhang largely intact. Such removal was dependent upon Ku, DNA-dependent protein kinase, and ATP. Together, these data suggest that Artemis-mediated cleavage of 3{prime} overhangs requires a minimum of 2 nucleotides, or a nucleotide plus a phosphoglycolate, 3{prime} to the cleavage site. Shorter 3{prime}-phosphoglycolate-terminated overhangs and blunt ends were also processed by Artemis, but much less efficiently. Consistent with the in vitro substrate specificity of Artemis, human cells lacking Artemis exhibited hypersensitivity to X-rays, bleomycin and neocarzinostatin, which all induce 3{prime}-phosphoglycolate-terminated double-strand breaks. Collectively, these results suggest that 3{prime}-phosphoglycolate termini and/or specific classes of DNA ends that arise from such blocked termini are relevant Artemis substrates in vivo.

  5. Induction of linear tracks of DNA double-strand breaks by -particle irradiation of

    E-Print Network [OSTI]

    Cai, Long

    Induction of linear tracks of DNA double- strand breaks by -particle irradiation of cells Jan Stap1,4, Przemek M Krawczyk1,4, Carel H Van Oven1, Gerrit W Barendsen2, Jeroen Essers3, Roland Kanaar3 & Jacob describe a procedure for induction of easily recognizable linear arrays of DSBs in nuclei of adherent

  6. A MICROBEAM STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS

    E-Print Network [OSTI]

    stained with different dyes. Directly irradiated cells have exhibited the expected early and linear dose by assessing DNA double-strand break (DSB) formation in situ with the rapid and sensitive c-H2AX focus formation assay. Utilising the Columbia University single-cell microbeam system to deliver 2 or 20

  7. Creating Directed Double-strand Breaks with the Ref Protein A NOVEL RecA-DEPENDENT NUCLEASE FROM BACTERIOPHAGE P1*S

    E-Print Network [OSTI]

    Cox, Michael M.

    tar- geted double-strand breaks at any chosen DNA sequence in an oligonucleotide-directed fashion. We elements. The N-terminal 76 amino acid residues are disordered; this flexible region is required

  8. Coordinateendonucleolytic 5' and 3' trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase

    SciTech Connect (OSTI)

    Povirk, Lawrence; Yannone, Steven M.; Khan, Imran S.; Zhou, Rui-Zhe; Zhou, Tong; Valerie, Kristoffer; F., Lawrence

    2008-02-18T23:59:59.000Z

    Previous work showed that, in the presence of DNA-PK, Artemis slowly trims 3'-phosphoglycolate-terminated blunt ends. To examine the trimming reaction in more detail, long internally labeled DNA substrates were treated with Artemis. In the absence of DNA-PK, Artemis catalyzed extensive 5' {yields} 3' exonucleolytic resection of double-stranded DNA. This resection required a 5'-phosphate but did not require ATP, and was accompanied by endonucleolytic cleavage of the resulting 3' overhang. In the presence of DNA-PK, Artemis-mediated trimming was more limited, was ATP-dependent, and did not require a 5'-phosphate. For a blunt end with either a 3'-phosphoglycolate or 3'-hydroxyl terminus, endonucleolytic trimming of 2-4 nucleotides from the 3'-terminal strand was accompanied by trimming of 6 nucleotides from the 5'-terminal strand. The results suggest that autophosphorylated DNA-PK suppresses the exonuclease activity of Artemis toward blunt-ended DNA, and promotes slow and limited endonucleolytic trimming of the 5'-terminal strand, resulting in short 3' overhangs that are trimmed endonucleolytically. Thus, Artemis and DNA-PK can convert terminally blocked DNA ends of diverse geometry and chemical structure to a form suitable for polymerase mediated patching and ligation, with minimal loss of terminal sequence. Such processing could account for the very small deletions often found at DNA double-strand break repair sites.

  9. Probability of double-strand breaks in genome-sized DNA by {gamma}-ray decreases markedly as the DNA concentration increases

    SciTech Connect (OSTI)

    Shimobayashi, Shunsuke F. [Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606-8502 (Japan); Iwaki, Takafumi [Fukui Institute for Fundamental Chemistry, Kyoto University, Kyoto 606-8103 (Japan); Mori, Toshiaki [Radiation Research Center, Osaka Prefecture University, Sakai 599-8570 (Japan); Yoshikawa, Kenichi [Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606-8502 (Japan); Faculty of Life and Medical Sciences, Doshisha University, Kyoto 610-0394 (Japan)

    2013-05-07T23:59:59.000Z

    By use of the single-molecule observation, we count the number of DNA double-strand breaks caused by {gamma}-ray irradiation with genome-sized DNA molecules (166 kbp). We find that P{sub 1}, the number of double-strand breaks (DSBs) per base pair per unit Gy, is nearly inversely proportional to the DNA concentration above a certain threshold DNA concentration. The inverse relationship implies that the total number of DSBs remains essentially constant. We give a theoretical interpretation of our experimental results in terms of attack of reactive species upon DNA molecules, indicating the significance of the characteristics of genome-sized giant DNA as semiflexible polymers for the efficiency of DSBs.

  10. Crystal Structure of E. coli RecE Protein Reveals a Toroidal Tetramer for Processing Double-Stranded DNA Breaks

    SciTech Connect (OSTI)

    Zhang, Jinjin; Xing, Xu; Herr, Andrew B.; Bell, Charles E.; (OSU); (UCIN)

    2009-07-21T23:59:59.000Z

    Escherichia coli RecE protein is part of the classical RecET recombination system that has recently been used in powerful new methods for genetic engineering. RecE binds to free double-stranded DNA (dsDNA) ends and processively digests the 5{prime}-ended strand to form 5{prime}-mononucleotides and a 3{prime}-overhang that is a substrate for single strand annealing promoted by RecT. Here, we report the crystal structure of the C-terminal nuclease domain of RecE at 2.8 {angstrom} resolution. RecE forms a toroidal tetramer with a central tapered channel that is wide enough to bind dsDNA at one end, but is partially plugged at the other end by the C-terminal segment of the protein. Four narrow tunnels, one within each subunit of the tetramer, lead from the central channel to the four active sites, which lie about 15 {angstrom} from the channel. The structure, combined with mutational studies, suggests a mechanism in which dsDNA enters through the open end of the central channel, the 5{prime}-ended strand passes through a tunnel to access one of the four active sites, and the 3{prime}-ended strand passes through the plugged end of the channel at the back of the tetramer.

  11. DNA Repair Decline During Mouse Spermiogenesis Results in the Accumulation of Heritable DNA Damage

    E-Print Network [OSTI]

    Marchetti, Francesco

    2008-01-01T23:59:59.000Z

    van Buul, D.G. de Rooij, DNA double-strand breaks and gamma-for the transition proteins in DNA strand break repair, FEBSBoissonneault, Stimulation of DNA repair by the spermatidal

  12. DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage

    E-Print Network [OSTI]

    Marchetti, Francesco

    2008-01-01T23:59:59.000Z

    van Buul, D.G. de Rooij, DNA double-strand breaks and gamma-for the transition proteins in DNA strand break repair, FEBSBoissonneault, Stimulation of DNA repair by the spermatidal

  13. auger electron-induced double-strand: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  14. Double stranded nucleic acid biochips

    DOE Patents [OSTI]

    Chernov, Boris; Golova, Julia

    2006-05-23T23:59:59.000Z

    This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector that includes a linker for immobilization on a matrix. A non-enzymatic method for synthesizing double-stranded nucleic acids with this novel connector enables the construction of inexpensive and robust dsDNA/dsRNA microarrays. DNA-DNA and DNA-protein interactions are investigated using the microarrays.

  15. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

    E-Print Network [OSTI]

    Ochi, Takashi; Blackford, Andrew N.; Coates, Julia; Jhujh, Satpal; Mehmood, Shahid; Tamura, Naoka; Travers, Jon; Wu, Qian; Draviam, Viji M.; Robinson, Carol V.; Blundell, Tom L.; Jackson, Stephen P.

    2015-01-09T23:59:59.000Z

    ) for 2 hours with end-to-end mixing at 4 °C. Beads were washed five times in IP buffer before resuspension in 2x SDS loading buffer. 5% input lysate was loaded alongside unless otherwise stated. Surface plasmon resonance SPR experiments were performed...

  16. Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity

    E-Print Network [OSTI]

    California at Berkeley, University of

    to benzene-induced hematotoxicity Min Shen1,Ă, Qing Lan1 , Luoping Zhang2 , Stephen Chanock1,3 , Guilan Li4; Email: shenmi@mail.nih.gov Benzene is a recognized hematotoxicant and carcinogen that produces genotoxic and indirectly by benzene metabolites. DSB may lead to chromosome aberrations, apoptosis and hematopoietic

  17. Identification, Exploitation and Manipulation of BRCA1-Dependent DNA Double-Strand Break and Interstrand Crosslink Repair in Breast and Ovarian Cancer Therapy

    E-Print Network [OSTI]

    Stecklein, Shane Richard

    2012-05-12T23:59:59.000Z

    required by my academic journey. Your encouragement, support and love will always be the greatest treasures of my life. vi Acknowledgements To my mentor, Dr. Roy Jensen, I can never fully express my gratitude... hope to continue working in this discipline for the rest of my life. To my co-mentor, Dr. Fariba Behbod, I thank you for your unwavering support and enthusiasm throughout my graduate career. Your decision to come to KUMC has truly been a blessing...

  18. DNA Repair Alterations in Children With Pediatric Malignancies: Novel Opportunities to Identify Patients at Risk for High-Grade Toxicities

    SciTech Connect (OSTI)

    Ruebe, Claudia E., E-mail: claudia.ruebe@uks.e [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany); Fricke, Andreas; Schneider, Ruth; Simon, Karin; Kuehne, Martin; Fleckenstein, Jochen [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany); Graeber, Stefan [Institute of Medical Biometrics, Epidemiology and Medical Informatics, Saarland University, Homburg/Saar (Germany); Graf, Norbert [Department of Pediatric Hematology and Oncology, Saarland University, Homburg/Saar (Germany); Ruebe, Christian [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany)

    2010-10-01T23:59:59.000Z

    Purpose: To evaluate, in a pilot study, the phosphorylated H2AX ({gamma}H2AX) foci approach for identifying patients with double-strand break (DSB) repair deficiencies, who may overreact to DNA-damaging cancer therapy. Methods and Materials: The DSB repair capacity of children with solid cancers was analyzed compared with that of age-matched control children and correlated with treatment-related normal-tissue responses (n = 47). Double-strand break repair was investigated by counting {gamma}H2AX foci in blood lymphocytes at defined time points after irradiation of blood samples. Results: Whereas all healthy control children exhibited proficient DSB repair, 3 children with tumors revealed clearly impaired DSB repair capacities, and 2 of these repair-deficient children developed life-threatening or even lethal normal-tissue toxicities. The underlying mutations affecting regulatory factors involved in DNA repair pathways were identified. Moreover, significant differences in mean DSB repair capacity were observed between children with tumors and control children, suggesting that childhood cancer is based on genetic alterations affecting DSB repair function. Conclusions: Double-strand break repair alteration in children may predispose to cancer formation and may affect children's susceptibility to normal-tissue toxicities. Phosphorylated H2AX analysis of blood samples allows one to detect DSB repair deficiencies and thus enables identification of children at risk for high-grade toxicities.

  19. adducts strand breaks: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  20. CtIP tetramer assembly is required for DNA-end resection and repair

    E-Print Network [OSTI]

    Davies, Owen R.; Forment, Josep V.; Sun, Meidai; Belotserkovskaya, Rimma; Coates, Julia; Galanty, Yaron; Demir, Mukerrem; Morton, Christopher; Rzechorzek, Neil; Jackson, Stephen P.; Pellegrini, Luca

    2015-01-05T23:59:59.000Z

    1     CtIP tetramer assembly is required for DNA-end resection and repair Owen R. Davies1,4*, Josep V. Forment1,2,3*, Meidai Sun1, Rimma Belotserkovskaya1,2, Julia Coates1,2, Yaron Galanty1,2, Mukerrem Demir1,2, Christopher Morton1... that a CtIP tetramer architecture is essential for effective DSB repair by homologous recombination. Keywords CtIP/RBBP8, double-strand DNA break repair, DNA-end resection, gene conversion, homologous recombination. 3...

  1. The DNA Single-Strand Break Repair Machinery Facilitates CAF-1-Mediated Histone Deposition at Oxidative DNA Strand Breaks

    E-Print Network [OSTI]

    Arman Nabatiyan; Zhihong Zeng; Keith W. Caldecott

    2012-02-01T23:59:59.000Z

    Oxidative DNA single strand breaks arise continuously in cells and defects in their repair have been implicated in neurological disease. While much progress has been made in understanding how chromosomal single strand breaks are repaired little is known about the changes chromatin structure that accompany this process. Here, we show that nascent recombinant histone H3.1 protein accumulates and is deposited into chromatin at sites of DNA strand breakage in quiescent human cells following oxidative stress, and that core components of the single-strand break repair machinery are required for this process. We show that the SSBR sensor and scaffold proteins poly (ADP-ribose) polymerase and XRCC1 facilitate accumulation of chromatin assembly factor-1 (CAF-1) at sites of oxidative DNA strand breakage, which in turn mediates the deposition of Histone H3.1. We also demonstrate that depletion of CAF-1 slows global rates of DNA strand break repair in quiescent cells following oxidative stress, demonstrating that single-strand break repair and histone deposition are tightly coordinated processes. These data describe a novel role for the DNA singlestrand break repair machinery and implicate histone turnover as a core component of the cellular response of quiescent cells to oxidative damage.

  2. ORIGINAL PAPER Ionizing radiation induces DNA double-strand breaks in bystander primary

    E-Print Network [OSTI]

    fibroblasts Mykyta V Sokolov1,2 , Lubomir B Smilenov3 , Eric J Hall3 , Igor G Panyutin1 , William M Bonner*,4

  3. Asymmetric quantum transport in a double-stranded Kronig-Penney model

    E-Print Network [OSTI]

    Taksu Cheon; Sergey S. Poghosyan

    2015-03-03T23:59:59.000Z

    We introduce a double-stranded Kronig-Penney model and analyze its transport properties. The asymmetric fluxes between two strands with suddenly alternating localization patterns are found as the energy is varied. The zero-size limit of the internal lines connecting two strands is examined using quantum graph vertices with four edges. We also consider a two-dimensional Kronig-Penney lattice with two types of alternating layers with $\\delta$ and $\\delta'$ connections, and show that the existence of energy bands in which the quantum flux can flow only in selected directions.

  4. Site-Selective Binding of Nanoparticles to Double-Stranded DNA via Peptide Nucleic Acid "Invasion"

    SciTech Connect (OSTI)

    Stadler, A.L.; van der Lelie, D.; Sun, D.; Maye, M. M.; Gang, O.

    2011-04-01T23:59:59.000Z

    We demonstrate a novel method for by-design placement of nano-objects along double-stranded (ds) DNA. A molecular intercalator, designed as a peptide nucleic acid (PNA)-DNA chimera, is able to invade dsDNA at the PNA-side due to the hybridization specificity between PNA and one of the duplex strands. At the same time, the single-stranded (ss) DNA tail of the chimera, allows for anchoring of nano-objects that have been functionalized with complementary ssDNA. The developed method is applied for interparticle attachment and for the fabrication of particle clusters using a dsDNA template. This method significantly broadens the molecular toolbox for constructing nanoscale systems by including the most conventional not yet utilized DNA motif, double helix DNA.

  5. Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5

    E-Print Network [OSTI]

    Strong, Roland K.

    Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5 Xiaojun Li online 14 June 2009 Keywords: Innate immunity Nucleic acid receptor MDA5 CTD Crystal structure a b s t r a c t RIG-I, MDA5 and LGP2 are cytosolic pattern recognition receptors detecting single

  6. Sequence-Enabled Reassembly of -Lactamase (SEER-LAC): A Sensitive Method for the Detection of Double-Stranded DNA

    E-Print Network [OSTI]

    Ghosh, Indraneel

    Sequence-Enabled Reassembly of -Lactamase (SEER-LAC): A Sensitive Method for the Detection the development of a new methodology for the detection of specific double- stranded DNA sequences. We previously of a predefined DNA sequence. This system, designated sequence-enabled reassembly (SEER), was demonstrated

  7. Mechanistic studies of bleomycin-mediated double-stranded DNA cleavage and structural studies of DNA containing normal and 4'-oxidized abasic sites

    E-Print Network [OSTI]

    Chen, Jingyang, Ph. D. Massachusetts Institute of Technology

    2006-01-01T23:59:59.000Z

    In order to examine the role of partial intercalation in double-stranded (ds) DNA cleavage mediated by a single bleomycin (BLM), a bulky group ([-cyclodextrin) was chemically attached to the polyamine tail of BLM A5 to ...

  8. Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic ?-cells

    SciTech Connect (OSTI)

    Chen, Shan-Shan [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China) [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China); Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing (China); Jiang, Teng [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China)] [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China); Wang, Yi; Gu, Li-Ze [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China) [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China); Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing (China); Wu, Hui-Wen [Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing (China)] [Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing (China); Tan, Lan [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China)] [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China); Guo, Jun, E-mail: Guoj@njmu.edu.cn [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China) [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China); Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing (China)

    2014-01-17T23:59:59.000Z

    Highlights: •PKR can be activated by glucolipitoxicity and pro-inflammatory cytokines in ?-cells. •Activated PKR inhibited ?-cell proliferation by arresting cell cycle at G1 phase. •Activated PKR fully abrogated the pro-proliferative effects of IGF-I on ?-cells. -- Abstract: Double-stranded RNA-dependent protein kinase (PKR) is revealed to participate in the development of insulin resistance in peripheral tissues in type 2 diabetes (T2DM). Meanwhile, PKR is also characterized as a critical regulator of cell proliferation. To date, no study has focused on the impact of PKR on the proliferation of pancreatic ?-cells. Here, we adopted insulinoma cell lines and mice islet ?-cells to investigate: (1) the effects of glucolipotoxicity and pro-inflammatory cytokines on PKR activation; (2) the effects of PKR on proliferation of pancreatic ?-cells and its underlying mechanisms; (3) the actions of PKR on pro-proliferative effects of IGF-I and its underlying pathway. Our results provided the first evidence that PKR can be activated by glucolipitoxicity and pro-inflammatory cytokines in pancreatic ?-cells, and activated PKR significantly inhibited cell proliferation by arresting cell cycle at G1 phase. Reductions in cyclin D1 and D2 as well as increases in p27 and p53 were associated with the anti-proliferative effects of PKR, and proteasome-dependent degradation took part in the reduction of cyclin D1 and D2. Besides, PKR activation abrogated the pro-proliferative effects of IGF-I by activating JNK and disrupting IRS1/PI3K/Akt signaling pathway. These findings indicate that the anti-proliferative actions of PKR on pancreatic ?-cells may contribute to the pathogenesis of T2DM.

  9. DNA Double-Strand Breaks Form in Bystander Cells after Microbeam Irradiation of Three-dimensional Human Tissue Models

    E-Print Network [OSTI]

    Brenner, David Jonathan

    Research Accelerator Facility, Center for Radiological Research, College of Physicians and Surgeons Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada; and 3 Radiological implications for cancer radiother- apy and diagnostic radiology as well as for human health in general

  10. Local compression properties of double-stranded DNA based on a dynamic simulation

    E-Print Network [OSTI]

    Xiaoling Lei; Wenpeng Qi; Haiping Fang

    2013-03-13T23:59:59.000Z

    The local mechanical properties of DNA are believed to play an important role in their biological functions and DNA-based nanomechanical devices. Using a simple sphere-tip compression system, the local radial mechanical properties of DNA are systematically studied by changing the tip size. The compression simulation results for the 16 nm diameter sphere tip are well consistent with the experimental results. With the diameter of the tip decreasing, the radial compressive elastic properties under external loads become sensitive to the tip size and the local DNA conformation. There appears a suddenly force break in the compression-force curve when the sphere size is less than or equal to 12 nm diameter. The analysis of the hydrogen bonds and base stacking interaction shows there is a local unwinding process occurs. During the local unwinding process, first the hydrogen bonds between complement base pairs are broken. With the compression aggregating, the local backbones in the compression center are unwound from the double helix conformation to a kind of parallel conformation. This local unwinding behavior deducing by external loads is helpful to understand the biological process, and important to DNA-based nanomechanical devices.

  11. Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs

    SciTech Connect (OSTI)

    Prins, Kathleen C.; Delpeut, Sebastien; Leung, Daisy W.; Reynard, Olivier; Volchkova, Valentina A.; Reid, St. Patrick; Ramanan, Parameshwaran; Cárdenas, Washington B.; Amarasinghe, Gaya K.; Volchkov, Viktor E.; Basler, Christopher F. (CNRS-INSERM); (Mount Sinai Hospital); (LB-Ecuador); (Iowa State)

    2010-10-11T23:59:59.000Z

    Ebola virus (EBOV) protein VP35 is a double-stranded RNA (dsRNA) binding inhibitor of host interferon (IFN)-{alpha}/{beta} responses that also functions as a viral polymerase cofactor. Recent structural studies identified key features, including a central basic patch, required for VP35 dsRNA binding activity. To address the functional significance of these VP35 structural features for EBOV replication and pathogenesis, two point mutations, K319A/R322A, that abrogate VP35 dsRNA binding activity and severely impair its suppression of IFN-{alpha}/{beta} production were identified. Solution nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography reveal minimal structural perturbations in the K319A/R322A VP35 double mutant and suggest that loss of basic charge leads to altered function. Recombinant EBOVs encoding the mutant VP35 exhibit, relative to wild-type VP35 viruses, minimal growth attenuation in IFN-defective Vero cells but severe impairment in IFN-competent cells. In guinea pigs, the VP35 mutant virus revealed a complete loss of virulence. Strikingly, the VP35 mutant virus effectively immunized animals against subsequent wild-type EBOV challenge. These in vivo studies, using recombinant EBOV viruses, combined with the accompanying biochemical and structural analyses directly correlate VP35 dsRNA binding and IFN inhibition functions with viral pathogenesis. Moreover, these studies provide a framework for the development of antivirals targeting this critical EBOV virulence factor.

  12. WHERE MULTIFUNCTIONAL DNA REPAIR PROTEINS MEET: MAPPING THE INTERACTION DOMAINS BETWEEN XPG AND WRN

    SciTech Connect (OSTI)

    Rangaraj, K.; Cooper, P.K.; Trego, K.S.

    2009-01-01T23:59:59.000Z

    The rapid recognition and repair of DNA damage is essential for the maintenance of genomic integrity and cellular survival. Multiple complex and interconnected DNA damage responses exist within cells to preserve the human genome, and these repair pathways are carried out by a specifi c interplay of protein-protein interactions. Thus a failure in the coordination of these processes, perhaps brought about by a breakdown in any one multifunctional repair protein, can lead to genomic instability, developmental and immunological abnormalities, cancer and premature aging. This study demonstrates a novel interaction between two such repair proteins, Xeroderma pigmentosum group G protein (XPG) and Werner syndrome helicase (WRN), that are both highly pleiotropic and associated with inherited genetic disorders when mutated. XPG is a structure-specifi c endonuclease required for the repair of UV-damaged DNA by nucleotide excision repair (NER), and mutations in XPG result in the diseases Xeroderma pigmentosum (XP) and Cockayne syndrome (CS). A loss of XPG incision activity results in XP, whereas a loss of non-enzymatic function(s) of XPG causes CS. WRN is a multifunctional protein involved in double-strand break repair (DSBR), and consists of 3’–5’ DNA-dependent helicase, 3’–5’ exonuclease, and single-strand DNA annealing activities. Nonfunctional WRN protein leads to Werner syndrome, a premature aging disorder with increased cancer incidence. Far Western analysis was used to map the interacting domains between XPG and WRN by denaturing gel electrophoresis, which separated purifi ed full length and recombinant XPG and WRN deletion constructs, based primarily upon the length of each polypeptide. Specifi c interacting domains were visualized when probed with the secondary protein of interest which was then detected by traditional Western analysis using the antibody of the secondary protein. The interaction between XPG and WRN was mapped to the C-terminal region of XPG as well as the C-terminal region of WRN. The physical interaction between XPG and WRN links NER, (made evident by the disease XP) with DSBR, which imparts additional knowledge of the overlapping nature of these two proteins and the previously distinct DNA repair pathways they are associated with. Since genomic integrity is constantly threatened by both endogenous and exogenous (internal and external) damage, understanding the roles of these proteins in coordinating DNA repair processes with replication will signifi cantly further understanding how defects instigate physiological consequences in response to various DNA damaging sources. This ultimately contributes to our understanding of cancer and premature aging.

  13. RADIATION SENSITIVITY & PROCESSING OF DNA DAMAGE FOLLOWING LOW DOSES OF GAMMA-RAY ALPHA PARTICLES & HZE IRRADIATION OF NORMAL DSB REPAIR DEFICIENT CELLS

    SciTech Connect (OSTI)

    O'Neil, Peter

    2009-05-15T23:59:59.000Z

    Non-homologous end joining (NHEJ) predominates in the repair of DNA double strand breaks (DSB) over homologous recombination (HR). NHEJ occurs throughout the cell cycle whereas HR occurs in late S/G2 due to the requirement of a sister chromatid (Rothkamm et al, Mol Cell Biol 23 5706-15 [2003]). To date evidence obtained with DSB repair deficient cells using pulsed-field gel electrophoresis has revealed the major pathway throughout all phases of the cell cycle for processing high dose induced DSBs is NHEJ (Wang et al, Oncogene 20 2212-24 (2001); Pluth et al, Cancer Res. 61 2649-55 [2001]). These findings however were obtained at high doses when on average >> 20-30 DSBs are formed per cell. The contribution of the repair pathways (NHEJ and HR) induced in response to DNA damage during the various phases of the cell cycle may depend upon the dose (the level of initial DSBs) especially since low levels of DSBs are induced at low dose. To date, low dose studies using NHEJ and HR deficient mutants have not been carried out to address this important question with radiations of different quality. The work presented here leads us to suggest that HR plays a relatively minor role in the repair of radiation-induced prompt DSBs. SSBs lead to the induction of DSBs which are associated specifically with S-phase cells consistent with the idea that they are formed at stalled replication forks in which HR plays a major role in repair. That DNA-PKcs is in some way involved in the repair of the precursors to replication-induced DSB remains an open question. Persistent non-DSB oxidative damage also leads to an increase in RAD51 positive DSBs. Both simple and complex non-DSB DNA damage may therefore contribute to indirect DSBs induced by ionising radiation at replication forks.

  14. Dose-dependent misrejoining of radiation-induced DNA double-strand breaks in human fibroblasts: Experimental and theoretical study for high and low LET radiation

    E-Print Network [OSTI]

    Rydberg, Bjorn; Cooper, Brian; Cooper, Priscilla K.; Holley, William; Chatterjee, Aloke

    2004-01-01T23:59:59.000Z

    S. Kim, and R. M. Myers. Radiation hybrid mapping: a somaticformulation of dual radiation action. Radiat. Res. 75: 471-High-Linear Energy Transfer Radiation in Human Fibroblasts.

  15. The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice

    E-Print Network [OSTI]

    Wiktor-Brown, Dominika M

    2007-01-01T23:59:59.000Z

    Mitotic homologous recombination is a critical pathway for the repair of DNA double-strand breaks and broken replication forks. Although homologous recombination is generally error-free, recombination between misaligned ...

  16. GENETIC AND MOLECULAR ANALYSIS OF DNA DAMAGE REPAIR AND TOLERANCE PATHWAYS.

    SciTech Connect (OSTI)

    SUTHERLAND, B.M.

    2001-07-26T23:59:59.000Z

    Radiation can damage cellular components, including DNA. Organisms have developed a panoply of means of dealing with DNA damage. Some repair paths have rather narrow substrate specificity (e.g. photolyases), which act on specific pyrimidine photoproducts in a specific type (e.g., DNA) and conformation (double-stranded B conformation) of nucleic acid. Others, for example, nucleotide excision repair, deal with larger classes of damages, in this case bulky adducts in DNA. A detailed discussion of DNA repair mechanisms is beyond the scope of this article, but one can be found in the excellent book of Friedberg et al. [1] for further detail. However, some DNA damages and paths for repair of those damages important for photobiology will be outlined below as a basis for the specific examples of genetic and molecular analysis that will be presented below.

  17. A novel high-throughput in-cell Western assay for the quantitative measurement of signaling dynamics in DNA damage signaling networks : cell decision processes in response to DNA double strand breaks

    E-Print Network [OSTI]

    Tentner, Andrea R. (Andrea Ruth)

    2006-01-01T23:59:59.000Z

    Following exposure to DNA damage, cells initiate a stress response involving multiple protein kinase signaling cascades. The DNA damage response results in one of several possible cell-fate decisions, or cellular responses: ...

  18. DNA end resection by Dna2Sgs1RPA and its stimulation by Top3Rmi1 and Mre11Rad50Xrs2

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    LETTERS DNA end resection by Dna2­Sgs1­RPA and its stimulation by Top3­Rmi1 and Mre11­Rad50­Xrs2. Campbell3 & Stephen C. Kowalczykowski1,2 The repair of DNA double-strand breaks (DSBs) by homologous to generate a 39-single- stranded DNA (ssDNA) overhang, which becomes a substrate forthe

  19. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Nancy Porter; Mike Sullivan; Chris Neary

    2003-05-01T23:59:59.000Z

    The two broad categories of deposited weld metal repair and fiber-reinforced composite repair technologies were reviewed for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Preliminary test programs were developed for both deposited weld metal repairs and for fiber-reinforced composite repair. To date, all of the experimental work pertaining to the evaluation of potential repair methods has focused on fiber-reinforced composite repairs. Hydrostatic testing was also conducted on four pipeline sections with simulated corrosion damage: two with composite liners and two without.

  20. aluminum strand coating: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov by assessing DNA double-strand break (DSB) formation in situ with the rapid and...

  1. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, Leo M. (Livermore, CA)

    1998-01-01T23:59:59.000Z

    Disclosed is a rapid road repair vehicle capable of moving over a surface to be repaired at near normal posted traffic speeds to scan for and find an the high rate of speed, imperfections in the pavement surface, prepare the surface imperfection for repair by air pressure and vacuum cleaning, applying a correct amount of the correct patching material to effect the repair, smooth the resulting repaired surface, and catalog the location and quality of the repairs for maintenance records of the road surface. The rapid road repair vehicle can repair surface imperfections at lower cost, improved quality, at a higher rate of speed than was was heretofor possible, with significantly reduced exposure to safety and health hazards associated with this kind of road repair activities in the past.

  2. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, L.M.

    1998-05-05T23:59:59.000Z

    Disclosed is a rapid road repair vehicle capable of moving over a surface to be repaired at near normal posted traffic speeds to scan for and find at the high rate of speed, imperfections in the pavement surface, prepare the surface imperfection for repair by air pressure and vacuum cleaning, applying a correct amount of the correct patching material to effect the repair, smooth the resulting repaired surface, and catalog the location and quality of the repairs for maintenance records of the road surface. The rapid road repair vehicle can repair surface imperfections at lower cost, improved quality, at a higher rate of speed than was not heretofor possible, with significantly reduced exposure to safety and health hazards associated with this kind of road repair activities in the past. 2 figs.

  3. Biochemical and Developmental Characterization of a SNF2-like ATPase Amplified in Liver Cancer 1 (ALC1)

    E-Print Network [OSTI]

    Gottschalk, Aaron James

    2010-06-07T23:59:59.000Z

    . Ino80 and Swr1 complexes regulate double-strand break repair. ...........................................26 Figure 8. SNF2 ATPases have specialized modes of chromatin remodeling. Nucleosome......................28 Figure 9. Model for translocation... that the Snf2-related chromatin remodeling complexes Ino80 and Swr1 have essential roles in DNA damage and recombination [60]. An interesting characteristic of Ino80 and Swr1 type remodeling complexes is that each includes Ruv-B like helicases as subunits...

  4. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Bill Bruce; Nancy Porter; George Ritter; Matt Boring; Mark Lozev; Ian Harris; Bill Mohr; Dennis Harwig; Robin Gordon; Chris Neary; Mike Sullivan

    2005-07-20T23:59:59.000Z

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. In lieu of a field installation on an abandoned pipeline, a preliminary nondestructive testing protocol is being developed to determine the success or failure of the fiber-reinforced liner pipeline repairs. Optimization and validation activities for carbon-fiber repair methods are ongoing.

  5. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-12-31T23:59:59.000Z

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. The first round of optimization and validation activities for carbon-fiber repairs are complete. Development of a comprehensive test plan for this process is recommended for use in the field trial portion of this program.

  6. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-08-17T23:59:59.000Z

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. Development of a comprehensive test plan for this process is recommended for use in the field trial portion of this program.

  7. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, Leo M. (Livermore, CA)

    1999-01-01T23:59:59.000Z

    Disclosed are improvments to a rapid road repair vehicle comprising an improved cleaning device arrangement, two dispensing arrays for filling defects more rapidly and efficiently, an array of pre-heaters to heat the road way surface in order to help the repair material better bond to the repaired surface, a means for detecting, measuring, and computing the number, location and volume of each of the detected surface imperfection, and a computer means schema for controlling the operation of the plurality of vehicle subsystems. The improved vehicle is, therefore, better able to perform its intended function of filling surface imperfections while moving over those surfaces at near normal traffic speeds.

  8. Motor Repair Tech Brief | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking ofOil &315_ArnibanPriorityof EnergyDepartmentRepair Tech Brief Motor

  9. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; Nancy Porter; Mike Sullivan; Chris Neary

    2004-04-12T23:59:59.000Z

    The two broad categories of deposited weld metal repair and fiber-reinforced composite liner repair technologies were reviewed for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Preliminary test programs were developed for both deposited weld metal repair and for fiber-reinforced composite liner repair. Evaluation trials have been conducted using a modified fiber-reinforced composite liner provided by RolaTube and pipe sections without liners. All pipe section specimens failed in areas of simulated damage. Pipe sections containing fiber-reinforced composite liners failed at pressures marginally greater than the pipe sections without liners. The next step is to evaluate a liner material with a modulus of elasticity approximately 95% of the modulus of elasticity for steel. Preliminary welding parameters were developed for deposited weld metal repair in preparation of the receipt of Pacific Gas & Electric's internal pipeline welding repair system (that was designed specifically for 559 mm (22 in.) diameter pipe) and the receipt of 559 mm (22 in.) pipe sections from Panhandle Eastern. The next steps are to transfer welding parameters to the PG&E system and to pressure test repaired pipe sections to failure. A survey of pipeline operators was conducted to better understand the needs and performance requirements of the natural gas transmission industry regarding internal repair. Completed surveys contained the following principal conclusions: (1) Use of internal weld repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling (HDD) when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) Pipe diameter sizes range from 50.8 mm (2 in.) through 1,219.2 mm (48 in.). The most common size range for 80% to 90% of operators surveyed is 508 mm to 762 mm (20 in. to 30 in.), with 95% using 558.8 mm (22 in.) pipe. An evaluation of potential repair methods clearly indicates that the project should continue to focus on the development of a repair process involving the use of GMAW welding and on the development of a repair process involving the use of fiber-reinforced composite liners.

  10. Breaking Earth Poems

    E-Print Network [OSTI]

    Hernandez, Scott Mcnaul

    2012-01-01T23:59:59.000Z

    CALIFORNIA RIVERSIDE Breaking Earth Poems A Thesis submittedFestival……………………………………………………………………..…..14 Earth Against Mylittle else in their hands. Earth Against My Back I lay in

  11. Window Replacement, Rehabilitation, & Repair Guides - Building...

    Energy Savers [EERE]

    Window Replacement, Rehabilitation, & Repair Guides - Building America Top Innovation Window Replacement, Rehabilitation, & Repair Guides - Building America Top Innovation Effec...

  12. WINTER BREAK HOUSING APPLICATION

    E-Print Network [OSTI]

    Hartman, Chris

    WINTER BREAK HOUSING APPLICATION RESIDENCE HALLS WILL BE CLOSED FROM 12:00PM (NOON), DECEMBER 19-6860 WWW.UAF.EDU/RESLIFE · EMAIL UAF-HOUSING@ALASKA.EDU TEL (907) 474-7247 · FAX (907) 474-6423 WINTER halls open need to complete the winter break housing application. Students that apply for housing before

  13. ageing human fibroblasts: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  14. ataxia telangiectasia fibroblasts: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  15. acidic fibroblast growth: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  16. ancient human dna: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  17. adult-onset primary open-angle: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  18. angiogenic gene-modified fibroblasts: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  19. acid-induced fibroblast cell: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  20. asymptomatic primary hyperparathyroidism: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  1. aliphatic primary diamines: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  2. autologous fibroblast metabolism: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  3. ancient dna studies: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  4. acid induces human: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  5. arthritis synovial fibroblasts: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STUDY OF DNA DOUBLE-STRAND BREAKS IN BYSTANDER PRIMARY HUMAN FIBROBLASTS L. B. Smilenov-or-nothing manner(7) . Bystander cells exhibit a variety of characteristics of...

  6. Industrial motor repair in the United States

    SciTech Connect (OSTI)

    Schueler, V.; Leistner, P.; Douglass, J.

    1994-09-01T23:59:59.000Z

    This report characterizes the motor repair industry in the United States; summarizes current motor repair and testing practice; and identifies barriers to energy motor repair practice and recommends strategies for overcoming those barriers.

  7. Finite group symmetry breaking

    E-Print Network [OSTI]

    G. Gaeta

    2005-10-02T23:59:59.000Z

    Finite group symmetry is commonplace in Physics, in particular through crystallographic groups occurring in condensed matter physics -- but also through the inversions (C,P,T and their combinations) occurring in high energy physics and field theory. The breaking of finite groups symmetry has thus been thoroughly studied, and general approaches exist to investigate it. In Landau theory, the state of a system is described by a finite dimensional variable (the {\\it order parameter}), and physical states correspond to minima of a potential, invariant under a group. In this article we describe the basics of symmetry breaking analysis for systems described by a symmetric polynomial; in particular we discuss generic symmetry breakings, i.e. those determined by the symmetry properties themselves and independent on the details of the polynomial describing a concrete system. We also discuss how the plethora of invariant polynomials can be to some extent reduced by means of changes of coordinates, i.e. how one can reduce to consider certain types of polynomials with no loss of generality. Finally, we will give some indications on extension of this theory, i.e. on how one deals with symmetry breakings for more general groups and/or more general physical systems.

  8. SuperBreak: Using Interactivity to Enhance Ergonomic Typing Breaks

    E-Print Network [OSTI]

    Rajamani, Sriram K.

    SuperBreak: Using Interactivity to Enhance Ergonomic Typing Breaks Dan Morris, A.J. Bernheim Brush Repetitive strain injuries and ergonomics concerns have become increasingly significant health issues software mechanisms exist for managing ergonomics; the most well-known are "break-reminder" packages

  9. Mammalian DNA Repair. Final Report

    SciTech Connect (OSTI)

    None

    2003-01-24T23:59:59.000Z

    The Gordon Research Conference (GRC) on Mammalian DNA Repair was held at Harbortown Resort, Ventura Beach, CA. Emphasis was placed on current unpublished research and discussion of the future target areas in this field.

  10. Inspect and Repair Steam Traps

    SciTech Connect (OSTI)

    Not Available

    2006-01-01T23:59:59.000Z

    This revised ITP tip sheet on inspecting and repairing steam traps provide how-to advice for improving industrial steam systems using low-cost, proven practices and technologies.

  11. New Technologies for Repairing Aging Cables in Nuclear Power Plants

    SciTech Connect (OSTI)

    Simmons, Kevin L.; Fifield, Leonard S.; Westman, Matthew P.

    2013-09-11T23:59:59.000Z

    The goal of this project is to demonstrate a proof-of-concept for a technique to repair aging cables that have been subjected to degradation associated with long-term thermal and radiation exposure in nuclear power plants. The physical degradation of the aging cables manifests itself primarily as cracking and increased brittleness of the polymeric electrical insulation. Therefore, the proposed cable-repair concept comprises development of techniques to impart a softening agent within the deteriorated polymer insulation jacket so as to regain the ability of the insulation to stretch without failing and possibly to heal existing cracks in the insulation. Our approach is to use commercially available ethylene-propylene rubber (EPR) as the relevant test material, demonstrate the adsorption of chemical treatments in the EPR and quantify changes in resulting physical and mechanical properties. EPR cable samples have been thermally treated in air to produce specimens corresponding to the full range of cable age-performance points from new (>350% elongation at break) to end-of-life (<50% elongation at break). The current focus is on two chemical treatments selected as candidates for restoring age-related cable elasticity loss: a rubber plasticizer and a reactive silane molecule. EPR specimens of 200, 150, 100, and 50% elongation at break have been soaked in the candidate chemical treatments and the kinetics of chemical uptake, measured by change in mass of the samples, has been determined. Mechanical properties as a function of aging and chemical treatment have been measured including ultimate tensile strength, tensile modulus at 50% strain, elongation at break, and storage modulus. Dimensional changes with treatment and changes in glass transition temperature were also investigated. These ongoing experiments are expected to provide insight into the physical-chemical nature of the effect of thermal degradation on EPR rejuvenation limits and to advance novel methods for restoring the ability of degraded EPR to be compliant and resist fracture. The results of this research reveal that absorption of chemical treatments can lower the glass transition temperature and modulus of EPR. Chemical treatments pursued thus far have proven ineffective at restoring EPR strength and elongation at break. Future work will combine the plasticizer modalities found to successfully increase the volume of the EPR, reduce EPR glass transition temperature and reduce EPR modulus with promising chemistries that will repair the damage of the polymer, potentially using the plasticizer as a host for the new chemistry.

  12. Verification of Motor Repair Quality

    E-Print Network [OSTI]

    Butler, K.

    Motor testing at Advanced Energy has shown that a motor that has not suffered irreparable damage as a result of failure can be repaired to perform as well as before the failure. But the only way to achieve the performance level of an energy...

  13. APPROVED Tie-Breaking Procedures

    E-Print Network [OSTI]

    Iglesia, Enrique

    a public school applicant attends a low API school (1-4), or if a private school to the rest of the tie-break pool. Spring Admission Applicants recommended, relative to the rest of the tie-break pool. #12;APPROVED Denied Admission

  14. Intense photoluminescence from dried double-stranded DNA and single-walled carbon nanotube hybrid

    SciTech Connect (OSTI)

    Ito, M.; Kobayashi, T.; Ito, Y.; Hayashida, T.; Nii, D.; Umemura, K.; Homma, Y. [Department of Physics, Tokyo University of Science, Tokyo 162-8601 (Japan)

    2014-01-27T23:59:59.000Z

    Semiconducting single-walled carbon nanotubes (SWNTs) show near-infrared photoluminescence (PL) when they are individually isolated. This was an obstacle to use photonic properties of SWNTs on a solid surface. We show that SWNTs wrapped with DNA maintain intense PL under the dry conditions. SWNTs are well isolated individually by DNA even when the DNA-SWNT hybrids are agglomerated. This finding opens up application of SWNTs to photonic devices.

  15. Screening Tool for Providers of Double-Stranded DNA - Energy Innovation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiationImplementingnpitcheResearchPhysics LabwildfiresScott Taylor,

  16. The Gordon conference on mammalian DNA repair

    SciTech Connect (OSTI)

    Cleaver, J.E.; Smerdon, M.J.

    1993-12-31T23:59:59.000Z

    A brief overview of the Gordon Conference on Mammalian Repair held February 1-5, 1993 in Ventura, California is presented.

  17. Chiral Symmetry Breaking in Graphene

    E-Print Network [OSTI]

    Gordon W. Semenoff

    2011-08-19T23:59:59.000Z

    The question of whether the Coulomb interaction is strong enough to break the sublattice symmetry of un-doped graphene is discussed. We formulate a strong coupling expansion where the ground state of the Coulomb Hamiltonian is found exactly and the kinetic hopping Hamiltonian is treated as a perturbation. We argue that many of the properties of the resulting system would be shared by graphene with a Hubbard model interaction. In particular, the best candidate sublattice symmetry breaking ground state is an antiferromagnetic Mott insulator. We discuss the results of some numerical simulations which indicate that the Coulomb interaction is indeed subcritical. We also point out the curious fact that, if the electron did not have spin degeneracy, the tendency to break chiral symmetry would be much greater and even relatively weak Coulomb interactions would likely gap the spectrum.

  18. Role of DNA repair protein ERCC1 in skin cancer 

    E-Print Network [OSTI]

    Song, Liang

    2009-01-01T23:59:59.000Z

    Nucleotide excision repair (NER) is one of the major repair systems for removal of DNA lesions. The NER pathway has evolved mainly to repair UV-induced DNA damage and is also active against a broad range of endogenously ...

  19. The feasibility of electrophoretic repair of impoundment leaks

    E-Print Network [OSTI]

    Han, Ji-Seok

    2002-01-01T23:59:59.000Z

    finding, repairing and testing the leaks, are tedious, expensive, and dangerous to workers. Electrophoretic repair technique is an innovative, economic, and safe method to repair the leakage of impoundments. A suspension of clay particles is induced...

  20. Automotive Repair by Number Theory Bart Snapp and Chris Snapp

    E-Print Network [OSTI]

    Snapp, Bart

    Automotive Repair by Number Theory Bart Snapp and Chris Snapp While repairing the ignition switch on a 1981 Fiat Spider, we discovered the following connection between number theory and automotive repair

  1. INTERNAL REPAIR OF PIPELINES REVIEW & EVALUATION OF INTERNAL PIPELINE REPAIR TRIALS REPORT

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-09-01T23:59:59.000Z

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is generally ineffective at restoring the pressure containing capabilities of pipelines. Failure pressure for pipe repaired with carbon fiber-reinforced composite liner was greater than that of the un-repaired pipe section with damage, indicating that this type of liner is effective at restoring the pressure containing capability of pipe. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. Development of a comprehensive test plan for this process is recommended for use in the next phase of this project.

  2. Baryon and chiral symmetry breaking

    SciTech Connect (OSTI)

    Gorsky, A. [Institute for Theoretical and Experimental Physics (ITEP), Moscow, Russia and Moscow Institute of Physics and Technology (MIPT), Dolgoprudny (Russian Federation); Krikun, A. [NORDITA, KTH Royal Institute of Technology and Stockholm University Stockholm, Sweden and Institute for Theoretical and Experimental Physics (ITEP), Moscow (Russian Federation)

    2014-07-23T23:59:59.000Z

    We briefly review the generalized Skyrmion model for the baryon recently suggested by us. It takes into account the tower of vector and axial mesons as well as the chiral symmetry breaking. The generalized Skyrmion model provides the qualitative explanation of the Ioffe’s formula for the baryon mass.

  3. Symmetry breaking in laser cavities

    E-Print Network [OSTI]

    Malomed, Boris A

    2015-01-01T23:59:59.000Z

    A brief introduction to the topic of spontaneous symmetry breaking (SSB) in conservative and dissipative nonlinear systems with an underlying double-well-potential structure is given. The reason is a discussion of a recent observation of the SSB a dual-core nanolaser cavity [5]. The effect is illustrated by means of a simple semi-analytically-tractable model (Fig. 1).

  4. CTRLWORK AND MACBREAKZ ERGONOMIC BREAK REMINDER SOFTWARE

    E-Print Network [OSTI]

    California at Santa Barbara, University of

    CTRLWORK AND MACBREAKZ ERGONOMIC BREAK REMINDER SOFTWARE SOFTWARE FEATURES: Analyzes your for installation assistance. 1. Please uninstall the former ergonomic break software, RSIGuard, if currently instructions on the screen. For more information, contact the UCSB Ergonomics Program at Ergonomics

  5. Developments advance subsea pipelaying, inspection, repair

    SciTech Connect (OSTI)

    NONE

    1997-09-15T23:59:59.000Z

    Recent advances in laying, inspecting, and repairing pipelines are helping to cut both costs and time. A new dredging system that employs jets to clear a subsea trench for pipelay received trials off Belgium last spring. Also, within the last year, projects in the Middle East and North Sea employed technologies that promise to make inspecting the surface of a subsea pipeline in difficult terrain easier, less time consuming, and therefore less costly. Plus, subsea repair of damaged pipelines may take less time with a new ``stabbable`` pipe connector. The paper describes jet dredging, inspection advance, support software, the North Sea site, and pipeline repair.

  6. DNA purification by triplex-affinity capture and affinity capture electrophoresis

    DOE Patents [OSTI]

    Cantor, Charles R. (Boston, MA); Ito, Takashi (Chiba, JP); Smith, Cassandra L. (Boston, MA)

    1996-01-01T23:59:59.000Z

    The invention provides a method for purifying or isolating double stranded DNA intact using triple helix formation. The method includes the steps of complexing an oligonucleotide and double stranded DNA to generate a triple helix and immobilization of the triple helix on a solid phase by means of a molecular recognition system such as avidin/biotin. The purified DNA is then recovered intact by treating the solid phase with a reagent that breaks the bonds between the oligonucleotide and the intact double stranded DNA while not affecting the Watson-Crick base pairs of the double helix. The present invention also provides a method for purifying or isolating double stranded DNA intact by complexing the double stranded DNA with a specific binding partner and recovering the complex during electrophoresis by immobilizing it on a solid phase trap imbedded in an electrophoretic gel.

  7. Chaotic inflation and supersymmetry breaking

    SciTech Connect (OSTI)

    Kallosh, Renata; Linde, Andrei; Rube, Tomas [Stanford Institute of Theoretical Physics and Department of Physics, Stanford University, Stanford, California 94305 (United States); Olive, Keith A. [William I. Fine Theoretical Physics Institute, University of Minnesota, Minneapolis, Minnesota 55455 (United States)

    2011-10-15T23:59:59.000Z

    We investigate the recently proposed class of chaotic inflation models in supergravity with an arbitrary inflaton potential V({phi}). These models are extended to include matter fields in the visible sector and we employ a mechanism of supersymmetry breaking based on a particular phenomenological version of the KKLT mechanism (the KL model). We describe specific features of reheating in this class of models and show how one can solve the cosmological moduli and gravitino problems in this context.

  8. Analysis of cell cycle surveillance mechanisms in meiosis

    E-Print Network [OSTI]

    Hochwagen, Andreas

    2006-01-01T23:59:59.000Z

    Numerous DNA double-strand breaks (DSBs) are introduced into the genome in the course of meiotic recombination. This poses a significant hazard to the genomic integrity of the cell. Studies in a number of organisms have ...

  9. CATASTROPHIC REPAIR REQUEST CHECKLIST Office of Research

    E-Print Network [OSTI]

    Schladow, S. Geoffrey

    Not Meet Policy Not Sure Equipment may not be covered by a service contract that provides for repair Contacted: ______________ Amount of Annual Service Contract: $ ___________ Meets Policy Info Pending Does

  10. Reducing Your Leak Rate Without Repairing Leaks 

    E-Print Network [OSTI]

    Beals, C.

    2005-01-01T23:59:59.000Z

    As plant personnel know, repairing compressed air leaks can be an expensive, labor intensive and never-ending process. This article discusses ways plant personnel can reduce and maintain their leak rate at a lower level ...

  11. Vehicle Repair Policy Outline the policy regarding vehicle repair on University of Michigan (U-M) vehicles.

    E-Print Network [OSTI]

    Kirschner, Denise

    Vehicle Repair Policy Objective Outline the policy regarding vehicle repair on University of Michigan (U-M) vehicles. Policy 1. All vehicle repairs performed on U-M vehicles must be coordinated facility to repair their fleet vehicles. 2. U-M vehicles leased through Fleet Services include routine

  12. Energy and Technology Review: Unlocking the mysteries of DNA repair

    SciTech Connect (OSTI)

    Quirk, W.A.

    1993-04-01T23:59:59.000Z

    DNA, the genetic blueprint, has the remarkable property of encoding its own repair following diverse types of structural damage induced by external agents or normal metabolism. We are studying the interplay of DNA damaging agents, repair genes, and their protein products to decipher the complex biochemical pathways that mediate such repair. Our research focuses on repair processes that correct DNA damage produced by chemical mutagens and radiation, both ionizing and ultraviolet. The most important type of DNA repair in human cells is called excision repair. This multistep process removes damaged or inappropriate pieces of DNA -- often as a string of 29 nucleotides containing the damage -- and replaces them with intact ones. We have isolated, cloned, and mapped several human repair genes associated with the nucleotide excision repair pathway and involved in the repair of DNA damage after exposure to ultraviolet light or mutagens in cooked food. We have shown that a defect in one of these repair genes, ERCC2, is responsible for the repair deficiency in one of the groups of patients with the recessive genetic disorder xeroderma pigmentosum (XP group D). We are exploring ways to purify sufficient quantities (milligrams) of the protein products of these and other repair genes so that we can understand their functions. Our long-term goals are to link defective repair proteins to human DNA repair disorders that predispose to cancer, and to produce DNA-repair-deficient mice that can serve as models for the human disorders.

  13. Unparticles and electroweak symmetry breaking

    SciTech Connect (OSTI)

    Lee, Jong-Phil [Korea Institute for Advanced Study, Seoul 130-722 (Korea, Republic of)

    2008-11-23T23:59:59.000Z

    We investigate a scalar potential inspired by the unparticle sector for the electroweak symmetry breaking. The scalar potential contains the interaction between the standard model fields and unparticle sector. It is described by the non-integral power of fields that originates from the nontrivial scaling dimension of the unparticle operator. It is found that the electroweak symmetry is broken at tree level when the interaction is turned on. The scale invariance of unparticle sector is also broken simultaneously, resulting in a physical Higgs and a new lighter scalar particle.

  14. HYDROGEN EFFECTS ON LASER ENGINEERED NET SHAPE (LENS) REPAIRED WELDMENTS

    SciTech Connect (OSTI)

    Korinko, P; Thad Adams, T

    2006-10-06T23:59:59.000Z

    New methods of repairing mis-machined components are always of interest. In this study, an innovative method using Laser Engineered Net Shape{trademark} (LENS{reg_sign}) forming was used to repair intentionally mis-machined test articles. The components were repaired and subsequently hydrogen charged and burst tested. The LENS repair did not have an adverse effect on the solid state weld process that was used to repair the components. Hydrogen charged samples failed in a similar manner to the uncharged samples. Overall, the prospects for LENS repairing similar products are favorable and further work is encouraged.

  15. Degeneracy Breaking of Hydrogen Atom

    E-Print Network [OSTI]

    Agung Trisetyarso; Pantur Silaban

    2014-11-21T23:59:59.000Z

    The three dimensional rotation group, SO(3), is a symmetry group of the normal hydrogen atom. Each reducible representation of this group can be associated with a degenerate energy level. If this atom is placed in an external magnetic field, the interaction between the orbital magnetic moment with this field will lead to a symmetry breaking where the symmetry group of the atom is a new group distinct from the SO(3) group. This phenomenon describes the normal Zeeman effect, where a degenerate energy level splits into several new energy levels. It is explicitly shown that each of the new energy levels can be associated with an irreducible representation of the new symmetry group.

  16. Alan Turing as a Statistician: Breaking the Code by Breaking the Bayesian Egg

    E-Print Network [OSTI]

    Wolfe, Patrick J.

    Alan Turing as a Statistician: Breaking the Code by Breaking the Bayesian Egg Joseph K. Blitzstein, Harvard University Alan Turing is widely considered the father of computer science. Yet even

  17. Repairable chip bonding/interconnect process

    DOE Patents [OSTI]

    Bernhardt, Anthony F. (Berkeley, CA); Contolini, Robert J. (Livermore, CA); Malba, Vincent (Livermore, CA); Riddle, Robert A. (Tracy, CA)

    1997-01-01T23:59:59.000Z

    A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder.

  18. Repairable chip bonding/interconnect process

    DOE Patents [OSTI]

    Bernhardt, A.F.; Contolini, R.J.; Malba, V.; Riddle, R.A.

    1997-08-05T23:59:59.000Z

    A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules is disclosed. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder. 10 figs.

  19. SNL Researchers Assess Wind Turbine Blade Inspection and Repair...

    Office of Environmental Management (EM)

    Researchers Assess Wind Turbine Blade Inspection and Repair Methods SNL Researchers Assess Wind Turbine Blade Inspection and Repair Methods May 18, 2015 - 5:32pm Addthis A picture...

  20. Phonemic Categorization and Phonotactic Repair as Parallel Sublexical Processes 

    E-Print Network [OSTI]

    Ishikawa, Kiyoshi

    2014-07-01T23:59:59.000Z

    categorization and phonotactic repair are sublexical and simultaneous; phonotactic repairs themselves depend on coarticulation cues. Such models can be implemented in two different versions: suprasegmental matching, according to which a speech signal is matched...

  1. Development of a composite repair system for reinforcing offshore risers

    E-Print Network [OSTI]

    Alexander, Christopher Richard

    2009-05-15T23:59:59.000Z

    A research program was conducted to investigate the application of composite materials in repairing corroded offshore risers, leading to the development of an optimized repair using a hybrid carbon/E-glass system. The objective of this research...

  2. Vanadium catalysts break down biomass for fuels

    E-Print Network [OSTI]

    - 1 - Vanadium catalysts break down biomass for fuels March 26, 2012 Vanadium catalysts break down biomass into useful components Due to diminishing petroleum reserves, non-food biomass (lignocellulose) is an attractive alternative as a feedstock for the production of renewable chemicals and fuels. The Department

  3. Gauge symmetry breaking in orbifold model building

    E-Print Network [OSTI]

    Michele Trapletti

    2006-11-02T23:59:59.000Z

    We review the gauge symmetry breaking mechanism due to orbifold projections in orbifold model building. We explicitly show the existence of a scale of breaking if such a symmetry breaking is due to freely-acting orbifold operators only, i.e. in case the breaking is realized non-locally in the internal space. We show that such a scale is related to the compactification moduli only, and that there are no extra continuous parameters, at least in semirealistic models with N=1 SUSY in four dimensions. In this sense, the mechanism is peculiarly different from the standard Higgs (or Hosotani) symmetry breaking mechanism. We show that the mechanism also differs from that present in standard orbifold models where, even in presence of discrete Wilson lines, a scale of breaking is generically missing, since the breaking is localized in specific points in the internal space. We review a set of background geometries where the described non-local breaking is realized, both in the case of two and six extra dimensions. In the latter case, relevant in string model building, we consider both heterotic and open string compactifications.

  4. Repairing Type Errors in Functional Programs 

    E-Print Network [OSTI]

    McAdam, Bruce J

    Type systems for programming languages can be used by compilers to reject programs which are found to be unsound and which may, therefore, fail to execute successfully. When a program is rejected the programmer must repair it so that it can be type...

  5. An emergency response team for membrane repair

    E-Print Network [OSTI]

    Kirchhausen, Tomas

    events, which we focus on here. As discussed later, Ca2+ influx at the site of plasma membrane-fusion events are required to repair a torn plasma membrane, and we propose that this emergency products and the plasma membrane. Reseal or die. Plasma-membrane disruption is a normal event in the life

  6. EPA Lead Safety for Renovation, Repair and

    E-Print Network [OSTI]

    Tennessee, University of

    EPA Lead Safety for Renovation, Repair and Painting (RRP) Course Certified Renovators Class, CSP, CHMM, Certified Lead Paint Inspector.; Certified Renovator; EPA Ac- credited Lead RRP trainer or fax registratio Registration Form Cash Method of Payment Check Name Mailing Address Phone Lead Safety

  7. Visualization of Mismatch Repair in Bacterial Cells

    E-Print Network [OSTI]

    Smith, Bradley T.

    We determined the localizations of mismatch repair proteins in living Bacillus subtilis cells. MutS-GFP colocalized with the chromosome in all cells and formed foci in a subset of cells. MutL-GFP formed foci in a subset ...

  8. Regulation of DNA repair by parkin

    SciTech Connect (OSTI)

    Kao, Shyan-Yuan, E-mail: shyan-yuan_kao@meei.harvard.edu [Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114 (United States)] [Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114 (United States)

    2009-05-01T23:59:59.000Z

    Mutation of parkin is one of the most prevalent causes of autosomal recessive Parkinson's disease (PD). Parkin is an E3 ubiquitin ligase that acts on a variety of substrates, resulting in polyubiquitination and degradation by the proteasome or monoubiquitination and regulation of biological activity. However, the cellular functions of parkin that relate to its pathological involvement in PD are not well understood. Here we show that parkin is essential for optimal repair of DNA damage. Parkin-deficient cells exhibit reduced DNA excision repair that can be restored by transfection of wild-type parkin, but not by transfection of a pathological parkin mutant. Parkin also protects against DNA damage-induced cell death, an activity that is largely lost in the pathological mutant. Moreover, parkin interacts with the proliferating cell nuclear antigen (PCNA), a protein that coordinates DNA excision repair. These results suggest that parkin promotes DNA repair and protects against genotoxicity, and implicate DNA damage as a potential pathogenic mechanism in PD.

  9. Antibody specific for a DNA repair protein

    DOE Patents [OSTI]

    Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

    2006-07-11T23:59:59.000Z

    An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

  10. DNA encoding a DNA repair protein

    DOE Patents [OSTI]

    Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

    2006-08-15T23:59:59.000Z

    An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

  11. Method for mask repair using defect compensation

    DOE Patents [OSTI]

    Sweeney, Donald W. (San Ramon, CA); Ray-Chaudhuri, Avijit K. (Livermore, CA)

    2001-01-01T23:59:59.000Z

    A method for repair of amplitude and/or phase defects in lithographic masks. The method involves modifying or altering a portion of the absorber pattern on the surface of the mask blank proximate to the mask defect to compensate for the local disturbance (amplitude or phase) of the optical field due to the defect.

  12. Laboratory testing of closure cap repair techniques

    SciTech Connect (OSTI)

    Persoff, P.; Moridis, G. [Lawrence Berkeley National Lab., CA (United States); Tuck, D.M. [Westinghouse Savannah River Company, Aiken, SC (United States)] [and others

    1996-10-01T23:59:59.000Z

    Landfill design requires a low permeability closure cap as well as a low permeability liner. The Savannah River Site, in South Carolina, has approximately 85 acres of mixed waste landfills covered with compacted kaolin clay. Maintaining low permeability of the clay cap requires both that the permeability of the compacted clay itself remain low and that the integrity of the barrier be maintained. Barrier breaches typically result from penetration by roots or animals, and especially cracks caused by uneven settling or desiccation. In this study, clay layers, 0.81 m in diameter and 7.6 cm thick, were compacted in 7 lysimeters to simulate closure caps. The hydraulic conductivity of each layer was measured, and the compacted clay layers (CCL`s) were cracked by drying. Then various repair techniques were applied and the effectiveness of each repair was assessed by remeasuring the hydraulic conductivity. Finally the repaired CCL was again dried and measured to determine how the repair responded to the conditions that caused the original failure. For a full report of this investigation see Persoff et al. Six repair techniques have been tested, four of which involve the use of injectable barrier liquids colloidal silica (CS) and polysiloxane (PSX) described below: (I) covering the crack with a bentonite geosynthetic clay liner (GCL), (ii) recompaction of new kaolinite at STD+3 moisture content joined to existing kaolinite that had dried and shrunk, (iii) direct injection of colloidal silica to a crack, (iv) injection of colloidal silica (CS) to wells in an overlying sand layer, (v) direct injection of polysiloxane to a crack, and (vi), injection of polysiloxane (PSX) to wells in an overlying soil layer.

  13. Explicit versus Spontaneous Diffeomorphism Breaking in Gravity

    E-Print Network [OSTI]

    Robert Bluhm

    2015-04-02T23:59:59.000Z

    Gravitational theories with fixed background fields break local Lorentz and diffeomorphism invariance either explicitly or spontaneously. In the case of explicit breaking it is known that conflicts can arise between the dynamics and geometrical constraints, while spontaneous breaking evades this problem. It is for this reason that in the gravity sector of the Standard-Model Extension (SME) it is assumed that the background fields (SME coefficients) originate from spontaneous symmetry breaking. However, in other examples, such as Chern-Simons gravity and massive gravity, diffeomorphism invariance is explicitly broken by the background fields, and the potential conflicts between the dynamics and geometry can be avoided in most cases. An analysis of how this occurs is given, and the conditions that are placed on the metric tensor and gravitational structure as a result of the presence of an explicit-breaking background are described. The gravity sector of the SME is then considered for the case of explicit breaking. However, it is found that a useful post-Newtonian limit is only obtained when the symmetry breaking is spontaneous.

  14. Helium bubble distributions in reactor tank repair specimens

    SciTech Connect (OSTI)

    Tosten, M.H.; Kestin, P.A.

    1992-03-01T23:59:59.000Z

    This report discusses the Reactor Tank Repair (RTR) program was initiated to develop an in-tank repair process capable of repairing stress corrosion cracks within the SRS reactor tank walls, in the event that such a repair is needed. Previous attempts to repair C-reactor tank with a gas tungsten arc (GTA) welding process were unsuccessful due to significant cracking that occurred in the heat-affected-zones adjacent to the repair welds. It was determined that this additional cracking was a result of helium embrittlement caused by the combined effects of helium (existing within the tank walls), the high heat input associated with the GTA process, and weld shrinkage stresses. Based on the results of earlier studies it was suggested that the effects of helium embrittlement could be minimized by using a low heat input GMA process. Metallographic analysis played an important role throughout the investigation of alternative welding methods for the repair of helium-containing materials.

  15. Laboratory Directed Research and Development Program. Annual report

    SciTech Connect (OSTI)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01T23:59:59.000Z

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

  16. Laboratory Directed Research and Development Program

    SciTech Connect (OSTI)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01T23:59:59.000Z

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

  17. Symmetry Breaking Revisited Jean-Francois Puget

    E-Print Network [OSTI]

    Flener, Pierre

    Symmetry Breaking Revisited Jean-Fran¸cois Puget ILOG, 9 avenue de Verdun, 94253 Gentilly, France, puget@ilog.fr Abstract. Symmetries in constraint satisfaction problems (CSPs) are one

  18. Holographic realization of gauge mediated supersymmetry breaking

    E-Print Network [OSTI]

    Kostas Skenderis; Marika Taylor

    2012-09-10T23:59:59.000Z

    The general gauge mediation scenario provides a framework in which properties of a visible sector with soft supersymmetry breaking are computed from current correlation functions in the supersymmetry breaking hidden sector. In this paper we will use holography to model strongly coupled hidden sectors by weakly curved geometries and describe how the current correlators relevant for general gauge mediation are computed by holographic methods. We illustrate the general setup by a toy example which captures most of the relevant features.

  19. Breaking Parity Symmetry Using Extra Dimensions

    E-Print Network [OSTI]

    R. N. Mohapatra; A. Pérez-Lorenzana

    1999-11-17T23:59:59.000Z

    We present a new way to break parity symmetry in left-right symmetric models using boundary conditions on the fields residing in the fifth dimension. We also discuss the connection between the limits on the size of extra dimensions and the scale of right handed symmetry breaking obtained from the analysis of neutrinoless double beta decay in the case where the righthanded gauge symmetry is in the bulk.

  20. Double-strand DNA-templated formation of copper nanoparticles as fluorescent probe for label free nuclease enzyme detection

    E-Print Network [OSTI]

    Tan, Weihong

    cleavage activity. Thus, a label-free strategy for sensitive detection of nuclease has been developed B.V. All rights reserved. 1. Introduction As promising substitutes for organic dyes and quantum dots epithelial cervical cancer cells (HeLa cells) using fluorescent gold nanoparticles which emitted a stable

  1. DNA repair is the target of novel antibiotics

    E-Print Network [OSTI]

    Gunderson, Carl Wayne

    2007-01-01T23:59:59.000Z

    W. & A. M. Segall, (2006) DNA repair, a novel antibacterialjunction-trapping peptides induce DNA damage and chromosomePeptide inhibitors of DNA cleavage by tyrosine recombinases

  2. Adenoviral E4orf3 and E4orf6 Proteins, But Not E1B55K, Increase Killing of Cancer Cells by Radiotherapy in vivo

    SciTech Connect (OSTI)

    Liikanen, Ilkka; Dias, Joao D.; Nokisalmi, Petri; Sloniecka, Marta; Kangasniemi, Lotta; Rajecki, Mari [Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Haartman Institute and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki (Finland); HUSLAB, Helsinki University Central Hospital, Helsinki (Finland); Dobner, Thomas [Heinrich Pette Institute for Experimental Virology and Immunology, Hamburg (Germany); Tenhunen, Mikko [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Kanerva, Anna [Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Haartman Institute and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki (Finland); Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki (Finland); Pesonen, Sari [Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Haartman Institute and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki (Finland); HUSLAB, Helsinki University Central Hospital, Helsinki (Finland); Ahtiainen, Laura Ph.D., E-mail: laura.ahtiainen@helsinki.f [Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Haartman Institute and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki (Finland); HUSLAB, Helsinki University Central Hospital, Helsinki (Finland); Hemminki, Akseli, E-mail: akseli.hemminki@helsinki.f [Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Haartman Institute and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki (Finland); HUSLAB, Helsinki University Central Hospital, Helsinki (Finland)

    2010-11-15T23:59:59.000Z

    Purpose: Radiotherapy is widely used for treatment of many tumor types, but it can damage normal tissues. It has been proposed that cancer cells can be selectively sensitized to radiation by adenovirus replication or by using radiosensitizing transgenes. Adenoviral proteins E1B55K, E4orf3, and E4orf6 play a role in radiosensitization, by targeting the Mre11, Rad50, and NBS1 complex (MRN) and inhibiting DNA double-strand break (DSB) repair. We hypothesize that combined with irradiation, these adenoviral proteins increase cell killing through the impairment of DSB repair. Methods and Materials: We assessed the radiosensitizing/additive potential of replication-deficient adenoviruses expressing E1B55K, E4orf3, and E4orf6 proteins. Combination treatments with low-dose external photon beam radiotherapy were studied in prostate cancer (PC-3MM2 and DU-145), breast cancer (M4A4-LM3), and head and neck cancer (UT-SCC8) cell lines. We further demonstrated radiosensitizing or additive effects in mice with PC-3MM2 tumors. Results: We show enhanced cell killing with adenovirus and radiation combination treatment. Co-infection with several of the viruses did not further increase cell killing, suggesting that both E4orf6 and E4orf3 are potent in MRN inhibition. Our results show that adenoviral proteins E4orf3 and E4orf6, but not E1B55K, are effective also in vivo. Enhanced cell killing was due to inhibition of DSB repair resulting in persistent double-strand DNA damage, indicated by elevated phospho-H2AX levels at 24 h after irradiation. Conclusions: This knowledge can be applied for improving the treatment of malignant tumors, such as prostate cancer, for development of more effective combination therapies and minimizing radiation doses and reducing side effects.

  3. Chimera Death: Symmetry Breaking in Dynamical Networks

    E-Print Network [OSTI]

    Anna Zakharova; Marie Kapeller; Eckehard Schöll

    2014-02-03T23:59:59.000Z

    For a network of generic oscillators with nonlocal topology and symmetry-breaking coupling we establish novel partially coherent inhomogeneous spatial patterns, which combine the features of chimera states (coexisting incongruous coherent and incoherent domains) and oscillation death (oscillation suppression), which we call chimera death. We show that due to the interplay of nonlocality and breaking of rotational symmetry by the coupling two distinct scenarios from oscillatory behavior to a stationary state regime are possible: a transition from an amplitude chimera to chimera death via in-phase synchronized oscillations, and a direct abrupt transition for larger coupling strength.

  4. Gauge mediated supersymmetry breaking and moduli stabilization

    SciTech Connect (OSTI)

    Alwis, S. P. de [Physics Department, University of Colorado, Boulder, Colorado 80309 (United States)

    2007-10-15T23:59:59.000Z

    A generic lesson of string theory is that the coupling constants of an effective low energy theory are determined by the vacuum values of a set of fields - the so-called moduli - some of which are stabilized at relatively low masses by nonperturbative effects. We argue that the physics of these moduli cannot be separated from the issues of dynamical and gauge mediated supersymmetry breaking. To illustrate this point we present a modified version of the type IIB Kachru-Kallosh-Linde-Trivedi model where the criteria for gauge mediated supersymmetry breaking may be realized.

  5. Comparison of protein patterns of xrs-5, a radiosensitive Chinese hamster ovary cell line, and CHO-K1, its radioresistant parent, using two-dimensional gel-electrophoresis

    SciTech Connect (OSTI)

    Kramer, J.M. (Miami Univ., Oxford, OH (USA). Dept. of Zoology)

    1991-01-01T23:59:59.000Z

    X-ray sensitive strains of Chinese hamster ovary cell lines have been used to analyze radiation repair mechanisms. One cell line, xrs-5, has been shown to be very sensitive to ionizing radiation and radical forming chemical mutagens. This sensitivity is thought to be a result a mutation in the DNA double strand break (DSB) repair mechanism, and its characterization has been a goal of several repair mechanism studies. Using two-dimensional gel electrophoresis, we have detected a protein (MW approximately 55KD) in the DNA/Nuclear Matrix (nucleoid) cell fraction of CHO-Kl cells that is absent in the nucleoid fraction of xrs-5. This protein is present, however, in both CHO-Kl and xrs-5 whole cell protein maps. To determine whether the 55KD protein is responsible for the radiosensitive and defective DSB repair phenotype of xrs-5 cells, studies are now underway to analyze revertants of xrs-5 that are proficient in DSB repair. Furthermore, an effort to sequence the protein in question is planned. 23 refs., 2 figs.

  6. Coherent testing and simulation of composite blade repair

    E-Print Network [OSTI]

    McNichols, Brian Glenn

    1997-01-01T23:59:59.000Z

    The objective of this research program is to experimentally and computationally determine the static and fatigue response for two methods of repair to an E/Glass-Epoxy sandwich laminate. The proposed methods of repair are a scarf and overlap patch...

  7. Computational model of aortic valve surgical repair using grafted pericardium

    E-Print Network [OSTI]

    1 Computational model of aortic valve surgical repair using grafted pericardium Peter E. Hammer1, aortic valve repair, membrane, surgical planning, leaflet graft, pericardium ABSTRACT Aortic valve leaflets. Difficulty is largely due to the complex geometry and function of the valve and the lower

  8. Quality electric motor repair: A guidebook for electric utilities

    SciTech Connect (OSTI)

    Schueler, V.; Douglass, J.

    1995-08-01T23:59:59.000Z

    This guidebook provides utilities with a resource for better understanding and developing their roles in relation to electric motor repair shops and the industrial and commercial utility customers that use them. The guidebook includes information and tools that utilities can use to raise the quality of electric motor repair practices in their service territories.

  9. Symmetry-Breaking Constraints for Matrix Models

    E-Print Network [OSTI]

    Flener, Pierre

    -breaking constraints. Experimental re- sults confirm their value. 1 Introduction Symmetry in a CSP model is an important issue as the exploration of symmet- ric but essentially equivalent branches in a search tree may techniques have been developed to address the issue of eliminating symmetry in CSP models. An important class

  10. Viscoplastic dam breaks and the Bostwick consistometer

    E-Print Network [OSTI]

    Balmforth, Neil

    Viscoplastic dam breaks and the Bostwick consistometer N. J. Balmforth, a R. V. Craster, b P'Informazione, Universit`a di Milano, Crema, Italy Abstract We present a theoretical and experimental analysis of the dam the broken dam) that may assist an experimentalist to unravel those dependences. Experiments are conducted

  11. Long Wave Breaking Effects on Fringing Reefs

    E-Print Network [OSTI]

    Goertz, John 1985-

    2012-12-12T23:59:59.000Z

    Calculated HRMS .................................................... 20? Figure 7: HRMS of JB07 vs. Directly Calculated HRMS ..................................................... 21? Figure 8: Dissipation Zones for Combined Probabilistic Model.... To find a better estimation of the constraints in this steep slope area, Janssen and Battjes (2007; hereafter JB07) can be used to estimate bulk dissipation. However, it is possible to investigate the breaking process at levels deeper than bulk...

  12. Using instrument scraper surveys for corrosion repair

    SciTech Connect (OSTI)

    Akhnoukh, S.R.; Baghabrah, M.A. (Aramco (SA))

    1990-07-01T23:59:59.000Z

    This paper reports on a program for overall pipe line repair. This program was implemented to maintain pipe line integrity and for identifying problem areas which require reconditioning or replacing by: reviewing pipe line leak history; checking periodically lifetime expectancy and integrity of pipe coatings; using cathodic protection annual survey results to locate low potential areas (close-interval survey is needed to identify the exact location of corrosion); and hydrotesting the pipe line (using leaks or ruptures from the hydrotest to identify problem areas). The pipe line revalidation plan is insufficient for identifying pipe line leaks. Instrumented pig testing provides more accurate and reliable ways of testing the pipe line for internal or external corrosion or defects.

  13. Assigning phrase breaks from part-of-speech sequences. 

    E-Print Network [OSTI]

    Black, Alan W; Taylor, Paul A

    1997-01-01T23:59:59.000Z

    One of the important stages in the process of turning unmarked text into speech is the assignment of appropriate phrase break boundaries. Phrase break boundaries are important to later modules including accent ...

  14. Winter Break 2011 (January) Knowledge is Power Program

    E-Print Network [OSTI]

    , TX) · Kentucky Equine Humane Center (Nicholsville, Kentucky) · Grand Canyon: Kane Ranch (Marble participants) · Community Collaborations, Flood Relief (Atlanta, GA) (10 participants) Weekend Breaks Fall 2009, San Juan, TX (10 participants) Weekend Break Fall 2008 (October)-12 participants · Cedar Rapids

  15. Collective neutrino oscillations and spontaneous symmetry breaking

    E-Print Network [OSTI]

    Duan, Huaiyu

    2015-01-01T23:59:59.000Z

    Neutrino oscillations in a hot and dense astrophysical environment such as a core-collapse supernova pose a challenging, seven-dimensional flavor transport problem. To make the problem even more difficult (and interesting), neutrinos can experience collective oscillations through nonlinear refraction in the dense neutrino medium in this environment. Significant progress has been made in the last decade towards the understanding of collective neutrino oscillations in various simplified neutrino gas models with imposed symmetries and reduced dimensions. However, a series of recent studies seem to have "reset" this progress by showing that these models may not be compatible with collective neutrino oscillations because the latter can break the symmetries spontaneously if they are not imposed. We review some of the key concepts of collective neutrino oscillations by using a few simple toy models. We also elucidate the breaking of spatial and directional symmetries in these models because of collective oscillation...

  16. Gravity dual of metastable dynamical supersymmetry breaking

    SciTech Connect (OSTI)

    DeWolfe, Oliver [Department of Physics, 390 UCB, University of Colorado, Boulder, Colorado 80309 (United States); Kachru, Shamit; Mulligan, Michael [Department of Physics and SLAC, Stanford University, Stanford, California 94305/94309 (United States)

    2008-03-15T23:59:59.000Z

    Metastable, supersymmetry-breaking configurations can be created in flux geometries by placing antibranes in warped throats. Via gauge/gravity duality, such configurations should have an interpretation as supersymmetry-breaking states in the dual field theory. In this paper, we perturbatively determine the asymptotic supergravity solutions corresponding to D3-brane probes placed at the tip of the cascading warped deformed conifold geometry, which is dual to an SU(N+M)xSU(N) gauge theory. The backreaction of the antibranes has the effect of introducing imaginary anti-self-dual flux, squashing the compact part of the space and forcing the dilaton to run. Using the generalization of holographic renormalization to cascading geometries, we determine the expectation values of operators in the dual field theory in terms of the asymptotic values of the supergravity fields.

  17. Navy Breaks World Record With Futuristic Free-Electron Laser...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    foxnews.comscitech20110218navy-breaks-world-record-futuristic-laser-getting-real Submitted: Sunday, February 20, 2011...

  18. Textural break foundation wall construction modules

    DOE Patents [OSTI]

    Phillips, Steven J. (Kennewick, WA)

    1990-01-01T23:59:59.000Z

    Below-grade, textural-break foundation wall structures are provided for inhibiting diffusion and advection of liquids and gases into and out from a surrounding hydrogeologic environment. The foundation wall structure includes a foundation wall having an interior and exterior surface and a porous medium disposed around a portion of the exterior surface. The structure further includes a modular barrier disposed around a portion of the porous medium. The modular barrier is substantially removable from the hydrogeologic environment.

  19. BREAK HOUSING HALLS NOTICE FOR SPRING SEMESTER HOUSING

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    BREAK HOUSING HALLS NOTICE FOR SPRING SEMESTER HOUSING BRETT | LEWIS | PRINCE | CASHIN NORTH AREA APARTMENTS #12;If you are cancelling your Break Housing assignment for the spring semester, you have two will receive a $100 refund of the Break Housing fee to your fall Bursar account. 2. If you remain beyond 6:00pm

  20. A tissue engineering strategy for integrative cartilage repair

    E-Print Network [OSTI]

    Mroszczyk, Keri A

    2014-01-01T23:59:59.000Z

    Tissue engineering for cartilage repair is a promising approach for improving the healing of articular defects, as biomaterials and growth factors can be supplied directly to a focal lesion. However, integrating neo-tissue ...

  1. Optimizing chondrogenic factors and protein delivery methods for cartilage repair

    E-Print Network [OSTI]

    Florine, Emily Marie

    2012-01-01T23:59:59.000Z

    Joint injuries are common and often result in damage to cartilage, which has a limited ability to repair itself. Tissue engineering is a promising approach for improving cartilage healing in which biomaterials and chemical ...

  2. Incremental temporal reasoning in job shop scheduling repair

    E-Print Network [OSTI]

    Huang, Y.

    A working predictive schedule can be useless because of the various external or internal disruptions in a job shop. Total rescheduling may cause problems such as shop floor nervousness. Thus, the job shop scheduling repair ...

  3. Availability Analysis of Repairable Computer Systems and Stationarity Detection

    E-Print Network [OSTI]

    Sericola, Bruno

    Availability Analysis of Repairable Computer Systems and Stationarity Detection Bruno Sericola AbstractĐPoint availability and expected interval availability are dependability measures respectively in this paper a new algorithm to compute these two availability measures. This algorithm is based

  4. Intermediate hearth repair technique at Thyssen Stahl AG

    SciTech Connect (OSTI)

    Kowalski, W.; Bachhofen, H.J.; Ruether, P.; Ballewski, T. [Thyssen Stahl AG, Duisburg (Germany)

    1996-12-31T23:59:59.000Z

    Nowadays various techniques for the fastest possible intermediate repair and/or emplacement of refractory materials above the tuyere level allow a significant extension of furnace campaign life. The latter are hence now exclusively determined by the service life of the hearth. The improvement of hearth monitoring and the estimation of residual brick strength of the refractory lining on the basis of temperature measurements in the hearth enable the location of individual zones of premature wear. These measurement methods, which were developed by Thyssen Stahl AG, aid the decision to undertake selective repair of the hearth. Three areas of repair are differentiated: taphole zone; hearth wall, localized; and hearth wall, extensive. This hearth repair method is described in this report using the example of hearth refurbishing blast furnace 8, Hamborn.

  5. Repair Sequences in American Learners of German Interlanguage

    E-Print Network [OSTI]

    Wisbey, Evelyn

    2010-04-25T23:59:59.000Z

    This study in Conversation Analysis investigates the organization of other-initiated repair sequences in American learners of German, i.e., it examines how learners deal with troubles in hearing or understanding that they ...

  6. To: Mansueti, Lawrence Subject: RE: Pepco Scheduled Line Repair...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Sent: Monday, January 29, 2007 6:28 PM To: Mansueti, Lawrence Subject: RE: Pepco Scheduled Line Repair Dec. 1-20, 2006 Larry, Regarding the planned line outage,...

  7. Providing protection: Agencies receive funding to repair, upgrade dams

    E-Print Network [OSTI]

    Wythe, Kathy

    2009-01-01T23:59:59.000Z

    Story by Kathy Wythe tx H2O | pg. 26 Providing protection Agencies receive funding to repair, upgrade dams along with local partners, can apply for grant funds, he said. Construction of the dams began through four federal authorizations..., called floodwater retarding structures and built mostly in rural areas during the 1950s to 1970s, are aging and need repairing. Others now protect urban areas that have developed downstream and need upgrading to meet more stringent safety standards...

  8. Breaking Barriers in Polymer Additive Manufacturing

    SciTech Connect (OSTI)

    Love, Lonnie J [ORNL; Duty, Chad E [ORNL; Post, Brian K [ORNL; Lind, Randall F [ORNL; Lloyd, Peter D [ORNL; Kunc, Vlastimil [ORNL; Peter, William H [ORNL; Blue, Craig A [ORNL

    2015-01-01T23:59:59.000Z

    Additive Manufacturing (AM) enables the creation of complex structures directly from a computer-aided design (CAD). There are limitations that prevent the technology from realizing its full potential. AM has been criticized for being slow and expensive with limited build size. Oak Ridge National Laboratory (ORNL) has developed a large scale AM system that improves upon each of these areas by more than an order of magnitude. The Big Area Additive Manufacturing (BAAM) system directly converts low cost pellets into a large, three-dimensional part at a rate exceeding 25 kg/h. By breaking these traditional barriers, it is possible for polymer AM to penetrate new manufacturing markets.

  9. Lattice String Breaking and Heavy Meson Decays

    E-Print Network [OSTI]

    I T Drummond; R R Horgan

    1998-11-11T23:59:59.000Z

    We show how string breaking on the lattice, treated as a mixing effect, can be related to decay rates for heavy quark systems. We use this to make a preliminary calculation of the energy split at maximum mixing for static quarks in QCD from the decay rate for $\\Upsilon(4S)\\to B{\\bar B}$. We extend the calculation to achieve rough estimates for the contributions of channels involving $B, B^*, B_s and B_s^*$ mesons to the width of the $\\Upsilon(5S)$.

  10. Dynamics of Symmetry Breaking and Tachyonic Preheating

    SciTech Connect (OSTI)

    Felder, Gary; Garcia-Bellido, Juan; Greene, Patrick B.; Kofman, Lev; Linde, Andrei; Tkachev, Igor

    2001-07-02T23:59:59.000Z

    We reconsider the old problem of the dynamics of spontaneous symmetry breaking (SSB) using 3D lattice simulations. We develop a theory of tachyonic preheating, which occurs due to the spinodal instability of the scalar field. Tachyonic preheating is so efficient that SSB typically completes within a single oscillation as the field rolls towards the minimum of its effective potential. We show that, contrary to previous expectations, preheating in hybrid inflation is typically tachyonic. Our results may also be relevant for the theory of the formation of topological defects and of disoriented chiral condensates in heavy ion collisions.

  11. Spontaneous Supersymmetry Breaking Induced by Vacuum Condensates

    E-Print Network [OSTI]

    Antonio Capolupo; Marco Di Mauro

    2012-08-29T23:59:59.000Z

    We propose a novel mechanism of spontaneous supersymmetry breaking which relies upon an ubiquitous feature of Quantum Field Theory, vacuum condensates. Such condensates play a crucial r\\^{o}le in many phenomena. Examples include Unruh effect, superconductors, particle mixing, and quantum dissipative systems. We argue that in all these phenomena supersymmetry, when present, is spontaneously broken. Evidence for our conjecture is given for the Wess--Zumino model, that can be considered an approximation to the supersymmetric extensions of the above mentioned systems. The magnitude of the effect is estimated for a recently proposed experimental setup based on an optical lattice.

  12. Chip breaking system for automated machine tool

    DOE Patents [OSTI]

    Arehart, Theodore A. (Clinton, TN); Carey, Donald O. (Oak Ridge, TN)

    1987-01-01T23:59:59.000Z

    The invention is a rotary selectively directional valve assembly for use in an automated turret lathe for directing a stream of high pressure liquid machining coolant to the interface of a machine tool and workpiece for breaking up ribbon-shaped chips during the formation thereof so as to inhibit scratching or other marring of the machined surfaces by these ribbon-shaped chips. The valve assembly is provided by a manifold arrangement having a plurality of circumferentially spaced apart ports each coupled to a machine tool. The manifold is rotatable with the turret when the turret is positioned for alignment of a machine tool in a machining relationship with the workpiece. The manifold is connected to a non-rotational header having a single passageway therethrough which conveys the high pressure coolant to only the port in the manifold which is in registry with the tool disposed in a working relationship with the workpiece. To position the machine tools the turret is rotated and one of the tools is placed in a material-removing relationship of the workpiece. The passageway in the header and one of the ports in the manifold arrangement are then automatically aligned to supply the machining coolant to the machine tool workpiece interface for breaking up of the chips as well as cooling the tool and workpiece during the machining operation.

  13. Large-Field Inflation and Supersymmetry Breaking

    E-Print Network [OSTI]

    Wilfried Buchmuller; Emilian Dudas; Lucien Heurtier; Clemens Wieck

    2014-07-14T23:59:59.000Z

    Large-field inflation is an interesting and predictive scenario. Its non-trivial embedding in supergravity was intensively studied in the recent literature, whereas its interplay with supersymmetry breaking has been less thoroughly investigated. We consider the minimal viable model of chaotic inflation in supergravity containing a stabilizer field, and add a Polonyi field. Furthermore, we study two possible extensions of the minimal setup. We show that there are various constraints: first of all, it is very hard to couple an O'Raifeartaigh sector with the inflaton sector, the simplest viable option being to couple them only through gravity. Second, even in the simplest model the gravitino mass is bounded from above parametrically by the inflaton mass. Therefore, high-scale supersymmetry breaking is hard to implement in a chaotic inflation setup. As a separate comment we analyze the simplest chaotic inflation construction without a stabilizer field, together with a supersymmetrically stabilized Kahler modulus. Without a modulus, the potential of such a model is unbounded from below. We show that a heavy modulus cannot solve this problem.

  14. 1Ottawa 7/05 Structural Break DetectionStructural Break Detection

    E-Print Network [OSTI]

    ://www.stat.colostate.edu/~rdavis/lectures) This research supported in part by an IBM faculty award. #12;2Ottawa 7/05 Introduction Setup Examples AR GARCH for structural break estimation Simulation results Applications Simulation results for GARCH and SSM #12;3Ottawa/05 Examples (cont) 2. Segmented GARCH model: where 0 = 1

  15. 'Jet breaks' and 'missing breaks' in the X-Ray afterglow of Gamma Ray Bursts

    E-Print Network [OSTI]

    Dado, Shlomo; De Rújula, Alvaro

    2008-01-01T23:59:59.000Z

    The X-ray afterglows (AGs) of Gamma-Ray Bursts (GRBs) and X-Ray Flashes (XRFs) have, after the fast decline phase of their prompt emission, a temporal behaviour varying between two extremes. A large fraction of these AGs has a 'canonical' light curve which, after an initial shallow-decay 'plateau' phase, 'breaks smoothly' into a fast power-law decline. Very energetic GRBs, contrariwise, appear not to have a 'break', their AG declines like a power-law from the start of the observations. Breaks and 'missing breaks' are intimately related to the geometry and deceleration of the jets responsible for GRBs. In the frame of the 'cannonball' (CB) model of GRBs and XRFs, we analyze the cited extreme behaviours (canonical and pure power-law) and intermediate cases spanning the observed range of X-ray AG shapes. We show that the entire panoply of X-ray light-curve shapes --measured with Swift and other satellites-- are as anticipated, on very limpid grounds, by the CB model. We test the expected correlations between the...

  16. Polymer nanocomposites for high-temperature composite repair

    SciTech Connect (OSTI)

    Sheng, Xia

    2008-12-01T23:59:59.000Z

    A novel repair agent for resin-injection repair of advanced high temperature composites was developed and characterized. The repair agent was based on bisphenol E cyanate ester (BECy) and reinforced with alumina nanoparticles. To ensure good dispersion and compatibility with the BECy matrix in nanocomposites, the alumina nanoparticles were functionalized with silanes. The BECy nanocomposites, containing bare and functionalized alumina nanoparticles, were prepared and evaluated for their thermal, mechanical, rheological, and viscoelastic properties. The monomer of BECy has an extremely low viscosity at ambient temperature, which is good for processability. The cured BECy polymer is a highly cross-linked network with excellent thermal mechanical properties, with a high glass transition temperature (T{sub g}) of 270 C and decomposition temperature above 350 C. The incorporation of alumina nanoparticles enhances the mechanical and rheological properties of the BECy nanocomposites. Additionally, the alumina nanoparticles are shown to catalyze the cure of BECy. Characterization of the nanocomposites included dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy. The experimental results show that the BECy nanocomposite is a good candidate as repair agent for resin-injection repair applications.

  17. Dynamical electroweak symmetry breaking and the top quark

    SciTech Connect (OSTI)

    Chivukula, R.S. [Boston Univ., MA (United States)

    1997-01-01T23:59:59.000Z

    In this talk, I discuss theories of dynamical electroweak symmetry breaking, with emphasis on the implications of a heavy top quark on the weak interaction {rho} parameter.

  18. Understanding the Electroweak Symmetry Breaking: The Higgs Boson...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Understanding the Electroweak Symmetry Breaking: The Higgs Boson and Beyond (Monday, March 2) DATE: Monday, March 2, 4:10 pm LOCATION: Physics 0003 Understanding the Electroweak...

  19. R-symmetry and Supersymmetry Breaking at Finite Temperature

    E-Print Network [OSTI]

    E. F. Moreno; F. A. Schaposnik

    2009-09-16T23:59:59.000Z

    We analyze the spontaneous $U(1)_R$ symmetry breaking at finite temperature for the simple O'Raifeartaigh-type model introduced in [1] in connection with spontaneous supersymmetry breaking. We calculate the finite temperature effective potential (free energy) to one loop order and study the thermal evolution of the model. We find that the R-symmetry breaking occurs through a second order phase transition. Its associated meta-stable supersymmetry breaking vacuum is thermodynamically favored at high temperatures and the model remains trapped in this state by a potential barrier, as the temperature lowers all the way until T=0.

  20. Isospin-Breaking quark condensates in Chiral Perturbation Theory

    E-Print Network [OSTI]

    A. Gomez Nicola; R. Torres Andres

    2011-11-14T23:59:59.000Z

    We analyze the isospin-breaking corrections to quark condensates within one-loop SU(2) and SU(3) Chiral Perturbation Theory including $m_u\

  1. Low energy dynamical supersymmetry breaking simplified

    SciTech Connect (OSTI)

    Dine, M. (Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California 95064 (United States)); Nelson, A.E. (Department of Physics, FM-15, University of Washington, Seattle,Washington 98195 (United States)); Shirman, Y. (Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California 95064 (United States))

    1995-02-01T23:59:59.000Z

    We present a model in which supersymmetry is dynamically broken at comparatively low energies. Previous efforts to construct simple models of this sort have been hampered by the presence of axions. The present model, which exploits an observation of Bagger, Poppitz, and Randall to avoid this problem, is far simpler than previous constructions. Models of this kind do not suffer from the naturalness difficulties of conventional supergravity models, and make quite definite predictions for physics over a range of scales from 100's of GeV to 1000's of TeV. Thus renormalizable visible sector models'' are a viable alternative to more conventional approaches. Our approach also yields a viable example of hidden sector dynamical supersymmetry breaking.

  2. Repairs for damaged bolt holes in continuous fiber reinforced plastics 

    E-Print Network [OSTI]

    Copps, Kevin Daniel

    1992-01-01T23:59:59.000Z

    repair method for damaged bolt holes in such composites. Bolt holes in three types of graphite-epoxy were purposely damaged and then repaired. Each was tested to characterize its static and fatigue behavior. The tests used a special fixture to simulate... composite joints . Bearing-bypass ratio can change the failure mode of bolted composite joints 7 Drilling defects in graphite-epoxy coupons 12 26 The exit side of a IM7/8551-7A 18 ply tape coupon showing the damage due to drilling 27 9 Resin filled...

  3. Developing Single-Molecule TPM Experiments for Direct Observation of Successful RecA-Mediated Strand

    E-Print Network [OSTI]

    Cox, Michael M.

    : This project is supported by National Science Council of Taiwan to HWL and the United States National information is crucial for cell survival. RecA-mediated homologous recombination repairs double-stranded (ds ssDNA and the dsDNA, with the ejection of the displaced strand, and (v) depolymerization of RecA from

  4. Development of criteria for fatigue repairs in bridge girders damaged by out-of-plane distortion

    E-Print Network [OSTI]

    Wilson, Scott David

    1994-01-01T23:59:59.000Z

    repaired and unrepaired cracks along the longitudinal web-to-flange connection of a plate girder subjected to a linear bending stress to determine if repair by drilling holes is really necessary. The results of the finite element analyses...

  5. Characterization of Mg Binding to the DNA Repair ProteinApurinic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mg Binding to the DNA Repair Protein ApurinicApyrimidic Endonuclease 1 via Solid-State Mg NMR Spectroscopy. Characterization of Mg Binding to the DNA Repair Protein Apurinic...

  6. An engineering analysis of natural and biomimetic self-repair processes for solar energy harvesting

    E-Print Network [OSTI]

    Boghossian, Ardemis A. (Ardemis Anoush)

    2012-01-01T23:59:59.000Z

    Plants have evolved highly sophisticated mechanisms of self-repair to regenerate proteins that become photo-damaged over time. Key to this self-repair process is the reversible self-assembly of protein complexes, which is ...

  7. Nuclear apoJ: A low dose radiation inducible regulator of cell death. Final report for period September 15, 1998 - September 14, 2001

    SciTech Connect (OSTI)

    Aronow, Bruce J.

    2002-04-19T23:59:59.000Z

    This project was based on preliminary data that was published by Dr. Boothman (Yang et al. 2000) which indicated a strong induction of apoJ gene expression, increased secretion of the protein, and accumulation of an apparently somewhat different form of the apoJ protein in the nucleus of MCF-7 breast carcinoma cells undergoing response to DNA damage. A clone expressing apoJ protein was isolated that was capable of interacting with Ku80, a component of the double strand break repair complex that is essential for the successful repair of rearranging immunoglobulin and T-cell receptor genes as evidenced by failure to produce mature B and T cells in the absence of Ku70. ApoJ clones isolated and characterized by Dr. Boothman bound strongly to a Ku-70 ''bait'' protein. Over-expression of these same clones in a cell line was capable of killing the cell. ApoJ is very strongly induced in many instances of programmed cell death and has been proposed repeatedly to play some sort of effector role in the process. Our principle hypothesis for this study was that the strong induction of the apoJ gene and the particular expression of a nuclear form of the protein was potentially a causal factor in the decision point made by the cell as it attempts to repair double-strand breakage based DNA damage. The hypothesis was that if sufficiently high damage occurred, it would be deleterious to maintain the cell's viability through continued DNA repair. One method to inhibit DNA repair might be by inhibiting proteins such as Ku-70 that are necessary for double-strand break repair. If apoJ does play a critical role in tipping the decision balance over to cell death, we reasoned that deficiency of apoJ would cause increased accumulation of cells with DNA damage and that this might decrease cell death in response to DNA damage and increase tumor occurrence rates. To test this hypothesis and its potential implications, we exposed wildtype and apoJ deficient animals that we constructed through gene targeting to increasing levels of ionizing radiation from a Cesium source. Data gathered under the support of this grant application initially indicated that apoJ deficient animals were more resistant to radiation, but as we accumulated more and more data points and covered a tighter exposure range, the genotype-based differences became insignificant. However, the possibility existed that because mortality based radiation-resistance could be attributable to mechanism for which nuclear apoJ was not rate determining, we maintained a very large of colony of apoJ knockout and wildtype animals in both the C57/B16 and Cv129 strain backgrounds that were exposed to sub-lethal levels of ionizing radiation to monitor for the occurrence of tumors. These animals were allowed to fully recover and age normally in either germ free or normal animal housing. Our results demonstrated no significant differences between wildtype and apoJ knockout animals over a period that extended up to 30 months for individual animals. We recorded similar weight gain, a relatively low mortality rate, and a similar mixture and rate of sarcoma and adenocarcinomas after surviving the initial ionizing radiation exposures. Thus we conclude that apoJ gene function, which was totally eliminated by our gene targeting, did not influence radiation sensitivity or serve as a tumor suppressor in response to DNA damage.

  8. Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities

    SciTech Connect (OSTI)

    Langland, Gregory T.; Yannone, Steven M.; Langland, Rachel A.; Nakao, Aki; Guan, Yinghui; Long, Sydney B.T.; Vonguyen, Lien; Chen, David J.; Gray, Joe W; Chen, Fanqing

    2009-09-07T23:59:59.000Z

    The variability of radiation responses in ovarian tumors and tumor-derived cell lines is poorly understood. Since both DNA repair capacity and p53 status can significantly alter radiation sensitivity, we evaluated these factors along with radiation sensitivity in a panel of sporadic human ovarian carcinoma cell lines. We observed a gradation of radiation sensitivity among these sixteen lines, with a five-fold difference in the LD50 between the most radiosensitive and the most radioresistant cells. The DNA-dependent protein kinase (DNA-PK) is essential for the repair of radiation induced DNA double-strand breaks in human somatic cells. Therefore, we measured gene copy number, expression levels, protein abundance, genomic copy and kinase activity for DNA-PK in all of our cell lines. While there were detectable differences in DNA-PK between the cell lines, there was no clear correlation with any of these differences and radiation sensitivity. In contrast, p53 function as determined by two independent methods, correlated well with radiation sensitivity, indicating p53 mutant ovarian cancer cells are typically radioresistant relative to p53 wild-type lines. These data suggest that the activity of regulatory molecules such as p53 may be better indicators of radiation sensitivity than DNA repair enzymes such as DNAPK in ovarian cancer.

  9. Symmetry breaking and low energy conformational fluctuations in

    E-Print Network [OSTI]

    Drabold, David

    Symmetry breaking and low energy conformational fluctuations in amorphous graphene Y. Li and D. A. Drabold* Department of Physics and Astronomy, Condensed Matter Surface Science Program, Ohio University Published online 21 December 2012 Keywords amorphous graphene, low-energy excitation, symmetry breaking

  10. Nonequilibrium symmetry breaking and pattern formation in magnetic films

    E-Print Network [OSTI]

    Deutsch, Josh

    films. ­ p. 7/6 #12;Applications of Ferromagnetism Doodle Pads Refrigerator Magnets NonequilibriumNonequilibrium symmetry breaking and pattern formation in magnetic films Josh Deutsch University of California Santa Cruz Nonequilibrium symmetry breaking and pattern formation in magnetic films. ­ p. 1/6 #12

  11. The Need for Language Repair The Reformation Algorithm Discussion Reformation: A Domain-Independent Algorithm

    E-Print Network [OSTI]

    St Andrews, University of

    The Need for Language Repair The Reformation Algorithm Discussion Reformation: A Domain of Edinburgh University of St Andrews, 27th November 2013 #12;The Need for Language Repair The Reformation Algorithm Discussion Outline 1 The Need for Language Repair 2 The Reformation Algorithm 3 Discussion #12;The

  12. Development of quick repairing technique for ceramic burner in hot stove of blast furnace

    SciTech Connect (OSTI)

    Kondo, Atsushi; Doura, Kouji; Nakamura, Hirofumi [Sumitomo Metal Industries, Ltd., Wakayama (Japan). Wakayama Steel Works

    1997-12-31T23:59:59.000Z

    Refractories of ceramic burner in hot stoves at Wakayama No. 4 blast furnace were damaged. There are only three hot stoves, so repairing must be done in a short. Therefore, a quick repairing technique for ceramic burners has been developed, and two ceramic burners were repaired in just 48 hours.

  13. Creaming and breaking of liquid emulsions: a free boundary problem 1 / 48 Creaming and breaking of liquid

    E-Print Network [OSTI]

    Rosso, Fabio

    , as opposite to the other case called instead a water-in-oil emulsion. #12;Creaming and breaking of liquid emulsions: a free boundary problem 4 / 48 What is an emulsion? Everyday life examples (a) water-in-oil of the model 5 A priori estimates 6 Existence and uniqueness #12;Creaming and breaking of liquid emulsions

  14. 1SCRA 2006 FIM XIII-PORTUGAL Structural Break Detection for a ClassStructural Break Detection for a Class

    E-Print Network [OSTI]

    1000 -4-202 Any breaks in this series? #12;5SCRA 2006 FIM XIII-PORTUGAL Introduction Examples AR GARCH for structural break estimation Simulation results Applications Simulation results for GARCH and SV models #12 (cont) 2. Segmented GARCH model: where 0 = 1

  15. 1NCAR-IMAGe 2006 Structural Break Detection in Time Series ModelsStructural Break Detection in Time Series Models

    E-Print Network [OSTI]

    -202 Any breaks in this series? #12;5NCAR-IMAGe 2006 Introduction Examples AR GARCH Stochastic volatility break estimation Simulation results Applications Simulation results for GARCH and SV models #12;6NCAR-tjptjptjjt tYYY jj GARCH model

  16. Charge symmetry breaking in $\\Lambda$ hypernuclei revisited

    E-Print Network [OSTI]

    Gal, Avraham

    2015-01-01T23:59:59.000Z

    The large charge symmetry breaking (CSB) implied by the $\\Lambda$ binding energy difference $\\Delta B^{4}_{\\Lambda}(0^+_{\\rm g.s.})\\equiv B_{\\Lambda}(_{\\Lambda}^4$He)$-$$B_{\\Lambda}(_{\\Lambda}^4$H) = 0.35$\\pm$0.06 MeV of the $A=4$ mirror hypernuclei ground states, determined from emulsion studies, has defied theoretical attempts to reproduce it in terms of CSB in hyperon masses and in hyperon-nucleon interactions, including one pion exchange arising from $\\Lambda-\\Sigma^0$ mixing. Using a schematic strong-interaction $\\Lambda N\\leftrightarrow\\Sigma N$ coupling model developed by Akaishi and collaborators for $s$-shell $\\Lambda$ hypernuclei, we revisit the evaluation of CSB in the $A=4$ $\\Lambda$ hypernuclei and extend it to $p$-shell mirror $\\Lambda$ hypernuclei. The model yields values of $\\Delta B^{4}_{\\Lambda} (0^+_{\\rm g.s.})\\sim 0.25$ MeV. Smaller size and mostly negative $p$-shell binding energy differences are calculated for the $A=7-10$ mirror hypernuclei, in rough agreement with the few available dat...

  17. HOW TO REPAIR A SECOND-ORDER SURFACE FOR COMPUTER

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 HOW TO REPAIR A SECOND-ORDER SURFACE FOR COMPUTER EXPERIMENTS BY KRIGING Astrid JOURDAN and analysis of computer experiments have been widely investigated in the past decade. Two approaches seem describes and compares them briefly in order to present a methodology for computer experiments based

  18. Thermosetting Polymer-Matrix Composites for Strucutral Repair Applications

    SciTech Connect (OSTI)

    William Kirby Goertzen

    2007-12-01T23:59:59.000Z

    Several classes of thermosetting polymer matrix composites were evaluated for use in structural repair applications. Initial work involved the characterization and evaluation of woven carbon fiber/epoxy matrix composites for structural pipeline repair. Cyanate ester resins were evaluated as a replacement for epoxy in composites for high-temperature pipe repair applications, and as the basis for adhesives for resin infusion repair of high-temperature composite materials. Carbon fiber/cyanate ester matrix composites and fumed silica/cyanate ester nanocomposites were evaluated for their thermal, mechanical, viscoelastic, and rheological properties as they relate to their structure, chemistry, and processing characteristics. The bisphenol E cyanate ester under investigation possesses a high glass transition temperature, excellent mechanical properties, and unique ambient temperature processability. The incorporate of fumed silica served to enhance the mechanical and rheological properties of the polymer and reduce thermal expansion without sacrificing glass transition or drastically altering curing kinetics. Characterization of the composites included dynamic mechanical analysis, thermomechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy.

  19. Development/Plasticity/Repair Identification of Nicotinic Acetylcholine Receptor Recycling

    E-Print Network [OSTI]

    Alford, Simon

    Development/Plasticity/Repair Identification of Nicotinic Acetylcholine Receptor Recycling and Its, University of Michigan, Ann Arbor, Michigan 48109 In the CNS, receptor recycling is critical for synaptic plasticity; however, the recycling of receptors has never been observed at peripheral synapses. Using a novel

  20. Corrosion Repair and Corrosion Protection of Reinforced Concrete Structures in

    E-Print Network [OSTI]

    Das, Suman

    11/14/2014 1 Corrosion Repair and Corrosion Protection of Reinforced Concrete Structures in Pulp and Paper Mills Vector Construction / Vector Corrosion Technologies www.vectorgroup.com www.vector-corrosion.com Presentation Outline · Introduction · Corrosion of Reinforced Concrete Structures · Protection of Chests

  1. Methods to alter levels of a DNA repair protein

    DOE Patents [OSTI]

    Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

    2006-10-17T23:59:59.000Z

    An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

  2. Breakthrough Technologies In Vivo Observation of Cavitation and Embolism Repair

    E-Print Network [OSTI]

    Holbrook, N. Michele

    Breakthrough Technologies In Vivo Observation of Cavitation and Embolism Repair Using Magnetic that approximately 10 vessels had cavitated during this time. Leaf water potentials decreased from 1.25 to 2.1 MPa cavitation. Refilling of xylem vessels occurred as soon as the lights were switched off, with the majority

  3. Development/Plasticity/Repair Group I Metabotropic Glutamate Receptors Control

    E-Print Network [OSTI]

    Grau, James

    Development/Plasticity/Repair Group I Metabotropic Glutamate Receptors Control Metaplasticity the spinal cord can support several forms of plasticity, including response­outcome (instrumental) learning. This inhibi- tion of plasticity in spinal learning is itself a form of plasticity that requires i

  4. Complications of Endovascular Repair of Abdominal Aortic Aneurysms: A Review

    SciTech Connect (OSTI)

    Katzen, Barry T. [Baptist Cardiac and Vascular Institute, Baptist Health Systems, Department of Interventional Radiology, Florida (United States)], E-mail: barryk@baptisthealth.net; MacLean, Alexandra A. [New York Hospital-Queens, Department of Surgery (United States)

    2006-12-15T23:59:59.000Z

    The endovascular procedure for repair of abdominal aortic aneurysms has had an enormous impact on the treatment of this challenging disease. Complications, however, do occur and it is important to have a thorough understanding of the array of complications and appropriate management strategies. In this review of endovascular complications, we describe early and late complications paying particular attention to preventive, treatment and surveillance strategies.

  5. Dynamical chiral symmetry breaking in strangelets at finite temperature

    E-Print Network [OSTI]

    Chang-Qun Ma; Chun-Yuan Gao

    2009-12-08T23:59:59.000Z

    A model for strangelets at finite temperature is built, in which the quark masses are dynamically generated. The dynamical chiral symmetry breaking inside strangelets at finite temperature is investigated. It is found that the chiral symmetry is going to break spontaneously inside the strangelets at some finite temperature, and then the masses of strange quarks inside the strangelets increase as the temperature rises. The phenomenon that strange quark mass increases with temperature after the chiral symmetry breaks spontaneously is illustrated by some typical numerical examples.

  6. Combined Haploinsufficiency for ATM and RAD9 as a Factor in Cell Transformation, Apoptosis, and DNA Lesion Repair Dynamics

    E-Print Network [OSTI]

    Lesion Repair Dynamics Lubomir B. Smilenov, Howard B. Lieberman, Stephen A. Mitchell, Ronald A. Baker

  7. Petra Nova Project Breaks Ground on World's Largest Post-Combustion...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Petra Nova Project Breaks Ground on World's Largest Post-Combustion Carbon Capture Project Petra Nova Project Breaks Ground on World's Largest Post-Combustion Carbon Capture...

  8. SciTech Connect: Sphericity and symmetry breaking in the formation...

    Office of Scientific and Technical Information (OSTI)

    and symmetry breaking in the formation of FrankKasper phases from one component materials Citation Details In-Document Search Title: Sphericity and symmetry breaking in the...

  9. Wave breaking along the stratospheric polar vortex as seen in ERA-40 data

    E-Print Network [OSTI]

    Abatzoglou, John T; Magnusdottir, Gudrun

    2007-01-01T23:59:59.000Z

    1983), Breaking planetary waves in the stratosphere, Nature,structure of breaking Rossby waves in the polar wintertimecontrol of upward wave flux near the tropopause, Geophys.

  10. The Role of Pendant Amines in the Breaking and Forming of Molecular...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pendant Amines in the Breaking and Forming of Molecular Hydrogen Catalyzed by Nickel Complexes. The Role of Pendant Amines in the Breaking and Forming of Molecular Hydrogen...

  11. Dynamical R-parity Breaking at the LHC

    E-Print Network [OSTI]

    Chen, Shao-Long; Mohapatra, Rabindra N; Zhang, Yue

    2010-01-01T23:59:59.000Z

    In a class of extensions of the minimal supersymmetric standard model with (B-L)/left-right symmetry that explains the neutrino masses, breaking R-parity symmetry is an essential and dynamical requirement for successful gauge symmetry breaking. Two consequences of these models are: (i) a new kind of R-parity breaking interaction that protects proton stability but adds new contributions to neutrinoless double beta decay and (ii) an upper bound on the extra gauge and parity symmetry breaking scale which is within the large hadron collider (LHC) energy range. We point out that an important prediction of such theories is a potentially large mixing between the right-handed charged lepton ($e^c$) and the superpartner of the right-handed gauge boson ($\\widetilde W_R^+$), which leads to a brand new class of R-parity violating interactions of type $\\widetilde{\\mu^c}^\\dagger\

  12. Tackling Epistemological Problems (TEP) A didactical engineering to break through

    E-Print Network [OSTI]

    Spagnolo, Filippo

    Tackling Epistemological Problems (TEP) A didactical engineering to break through the amazing world, becomes a didactical obstacle for the learning of this geometry. We need to use 3D models and also dynamic

  13. Assigning phrase breaks from part-of-speech sequences 

    E-Print Network [OSTI]

    Taylor, Paul; Black, Alan W

    This paper presents an algorithm for automatically assigning phrase breaks to unrestricted text for use in a text-to-speech synthesizer. Text is first converted into a sequence of part-of-speech tags. Next a Markov model ...

  14. Sets of Symmetry Breaking Constraints Barbara M. Smith

    E-Print Network [OSTI]

    Smith, Barbara M.

    Sets of Symmetry Breaking Constraints Barbara M. Smith Cork Constraint Computation Centre, University College Cork, Ireland b.m.smith@4c.ucc.ie Abstract [Puget, 2004] has shown that if the symmetry

  15. Holographic theories of electroweak symmetry breaking without a Higgs Boson

    E-Print Network [OSTI]

    Burdman, Gustavo; Nomura, Yasunori

    2003-01-01T23:59:59.000Z

    Breaking without a Higgs Boson Gustavo Burdman a and1] or theories where the Higgs boson arises as a compositeto build models of a composite Higgs boson [4] and dynamical

  16. The Independent Caucus: Breaking the Rubber Stamp Mold

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    The Independent Caucus: Breaking the Rubber Stamp Mold Chicago City Council Report May 21, 2007 in its voting patterns. It remains to be seen if this new oppositional bloc will undermine the rubber

  17. Novel Thermal Break with Simplified Manufacturing for R7 Commercial...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (R5 OptiQ-Ultra Thermal Windows). Windows incorporating the foam-based sandwich-type thermal-break would achieve U-Factor of 0.14 Btuhr-ft2-F (R7 or better) with...

  18. Dynamics of Wave Breaking at a Coastal Sea Wall

    E-Print Network [OSTI]

    Antoine, Arthur L.

    2010-07-14T23:59:59.000Z

    etc). Even the "Factor of Safety" which is regularly used in designs to account for unknown and/or unforeseen situations which might occur implies a degree of uncertainty about the dynamic scenario of breaking waves in the coastal environment...

  19. Synchronous Symmetry Breaking in Neurons with Different Neurite Counts

    E-Print Network [OSTI]

    Wissner-Gross, Zachary D.

    As neurons develop, several immature processes (i.e., neurites) grow out of the cell body. Over time, each neuron breaks symmetry when only one of its neurites grows much longer than the rest, becoming an axon. This symmetry ...

  20. Biomolecular Simulation of Base Excision Repair and Protein Signaling

    SciTech Connect (OSTI)

    Straatsma, TP; McCammon, J. A.; Miller, John H.; Smith, Paul E.; Vorpagel, Erich R.; Wong, Chung F.; Zacharias, Martin W.

    2006-03-03T23:59:59.000Z

    The goal of the Biomolecular Simulation of Base Excision Repair and Protein Signaling project is to enhance our understanding of the mechanism of human polymerase-?, one of the key enzymes in base excision repair (BER) and the cell-signaling enzymes cyclic-AMP-dependent protein kinase. This work used molecular modeling and simulation studies to specifically focus on the • dynamics of DNA and damaged DNA • dynamics and energetics of base flipping in DNA • mechanism and fidelity of nucleotide insertion by BER enzyme human polymerase-? • mechanism and inhibitor design for cyclic-AMP-dependent protein kinase. Molecular dynamics simulations and electronic structure calculations have been performed using the computer resources at the Molecular Science Computing Facility at the Environmental Molecular Sciences Laboratory.

  1. Testing and evaluation of grout repaired tubular members 

    E-Print Network [OSTI]

    Nunn, John Mansfield

    1992-01-01T23:59:59.000Z

    of Failed Weld Seam page 64 65 66 69 73 74 80 82 31 Ideahzed Tubular Dented Member for the Taby, Zhou, and the Parsanejad Methods. . . . . . . . . . . . . . , . 92 32 Dent Geometry for the Elhnas Method 96 33 Experimental Ultimate Capamty vs P... commonly used to repiur damaged tubular members. These include 1 ) welding a sleeve around the outside of the member in the location of the damage, 2 ) applying an externally grouted clamp, and 3 ) applying internal grout Ideally, the repair method...

  2. Waste-audit study: Automotive repairs. Final report

    SciTech Connect (OSTI)

    Toy, W.M.

    1987-05-01T23:59:59.000Z

    This document reports on a waste audit study which investigated and analyzed the automotive-repair industry in California. It assessed current waste-management practices and developed specific on-site and off-site waste-treatment recycling alternatives. The conclusions identify and address illegal disposal practices. Recommendations include the segregation of specific wastes for proper disposal and economic analysis of on-site waste-recycling equipment.

  3. 1Kaiserslautern 9/05 Structural Break Detection in Time Series ModelsStructural Break Detection in Time Series Models

    E-Print Network [OSTI]

    Regressive Modeling 4 pieces, 2.58 seconds. #12;4Kaiserslautern 9/05 Introduction Examples AR GARCH Stochastic for structural break estimation Simulation results Applications Simulation results for GARCH and SSM #12. Segmented GARCH model: where 0 = 1

  4. RADIATION RESEARCH 169, 17 (2008) 0033-7587/08 $15.00

    E-Print Network [OSTI]

    2008-01-01T23:59:59.000Z

    1 RADIATION RESEARCH 169, 1­7 (2008) 0033-7587/08 $15.00 2008 by Radiation Research Society. All and Double-Strand Breaks ­ All's Well that ``Ends'' Well. . . . Radiat. Res. 169, 1­7 (2008). Sometimes one--they protected the physical ends of chromosomes from interaction with broken DNA ends created by ionizing radi

  5. DNA damage responses in the context of the cell division cycle

    E-Print Network [OSTI]

    Giunta, Simona

    2010-11-16T23:59:59.000Z

    During my PhD, I have investigated aspects of the DNA damage response (DDR) in the context of three different cellular scenarios: DNA damage signalling in response to double-strand breaks during mitosis, coordination of DNA replication with DNA...

  6. Monosporascus root rot/vine decline: a study of double-stranded (DS) RNA and its role in the pathogenesis of Monosporascus cannonballus on muskmelon

    E-Print Network [OSTI]

    Batten, Jeffrey Samuel

    1997-01-01T23:59:59.000Z

    dodecyl sulfate (SDS), and 10 mg of carborundum (Sigma Chemical Co. , St. Louis, MO) for 1 min and incubated for 30 min at 37'C to allow for degradation of host RNAs. Nucleic acids were extracted with an equal volume of TE saturated phenol...

  7. Double-stranded RNA interferes in a sequence-specific manner with the infection of representative members of the two viroid families

    SciTech Connect (OSTI)

    Carbonell, Alberto; Martinez de Alba, Angel-Emilio [Instituto de Biologia Molecular y Celular de Plantas (UPV-CSIC), Campus Universidad Politecnica, Avenida de los Naranjos, s/n, 46022 Valencia (Spain); Flores, Ricardo [Instituto de Biologia Molecular y Celular de Plantas (UPV-CSIC), Campus Universidad Politecnica, Avenida de los Naranjos, s/n, 46022 Valencia (Spain)], E-mail: rflores@ibmcp.upv.es; Gago, Selma [Instituto de Biologia Molecular y Celular de Plantas (UPV-CSIC), Campus Universidad Politecnica, Avenida de los Naranjos, s/n, 46022 Valencia (Spain)

    2008-02-05T23:59:59.000Z

    Infection by viroids, non-protein-coding circular RNAs, occurs with the accumulation of 21-24 nt viroid-derived small RNAs (vd-sRNAs) with characteristic properties of small interfering RNAs (siRNAs) associated to RNA silencing. The vd-sRNAs most likely derive from dicer-like (DCL) enzymes acting on viroid-specific dsRNA, the key elicitor of RNA silencing, or on the highly structured genomic RNA. Previously, viral dsRNAs delivered mechanically or agroinoculated have been shown to interfere with virus infection in a sequence-specific manner. Here, we report similar results with members of the two families of nuclear- and chloroplast-replicating viroids. Moreover, homologous vd-sRNAs co-delivered mechanically also interfered with one of the viroids examined. The interference was sequence-specific, temperature-dependent and, in some cases, also dependent on the dose of the co-inoculated dsRNA or vd-sRNAs. The sequence-specific nature of these effects suggests the involvement of the RNA induced silencing complex (RISC), which provides sequence specificity to RNA silencing machinery. Therefore, viroid titer in natural infections might be regulated by the concerted action of DCL and RISC. Viroids could have evolved their secondary structure as a compromise between resistance to DCL and RISC, which act preferentially against RNAs with compact and relaxed secondary structures, respectively. In addition, compartmentation, association with proteins or active replication might also help viroids to elude their host RNA silencing machinery.

  8. ESI/TOF Measurements of a Noncovalent Complex between Lactose Repressor Protein (LacI) and Double-Stranded DNA Containing its Specific Operator Sequence

    E-Print Network [OSTI]

    Ens, Werner

    M buffer solution. Initial attempts to observe the protein tetramer were unsuccessful (as in the case rather broad peaks for both dimer and tetramer. The tetramer appears in two separate envelopes, suggesting that the the charge states 20 to 22 between m/z 7000 and 8000 represent the native tetramer

  9. The horizontal dam break problem for slow non-Newtonian power-law fluids

    E-Print Network [OSTI]

    The horizontal dam break problem for slow non-Newtonian power-law fluids P. Saramito a C. Smutek bLaboratoire g´eosciences ­ IPGP et universit´e de La R´eunion, France Abstract ­ The dam break problem shallow for the horizontal dam break problem. Keywords ­ viscoplastic fluid; dam break problem; shallow flows. 1

  10. Enhancement of the RAD51 Recombinase Activity by the Tumor Suppressor PALB2

    SciTech Connect (OSTI)

    Dray, Eloise; Etchin, Julia; Wiese, Claudia; Saro, Dorina; Williams, Gareth J.; Hammel, Michal; Yu, Xiong; Galkin, Vitold E.; Liu, Dongqing; Tsai, Miaw-Sheue; Sy, Shirley M-H.; Egelman, Edward; Chen, Junjie; Sung, Patrick; Schild, D.

    2010-08-24T23:59:59.000Z

    Homologous recombination mediated by the RAD51 recombinase helps eliminate chromosomal lesions, such as DNA double-stranded breaks induced by radiation or arising from injured DNA replication forks. The tumor suppressors BRCA2 and PALB2 act together to deliver RAD51 to chromosomal lesions to initiate repair. Here we document a new function of PALB2 in the enhancement of RAD51's ability to form the D-loop. We show that PALB2 binds DNA and physically interacts with RAD51. Importantly, while PALB2 alone stimulates D-loop formation, a cooperative effect is seen with RAD51AP1, an enhancer of RAD51. This stimulation stems from PALB2's ability to function with RAD51 and RAD51AP1 to assemble the synaptic complex. Our results help unveil a multi-faceted role of PALB2 in chromosome damage repair. Since PALB2 mutations can cause breast and other tumors or lead to Fanconi anemia, our findings are important for understanding the mechanism of tumor suppression in humans.

  11. Explicit Supersymmetry Breaking on Boundaries of Warped Extra Dimensions

    SciTech Connect (OSTI)

    Hall, Lawrence J.; Nomura, Yasunori; Okui, Takemichi; Oliver, Steven J.

    2003-02-25T23:59:59.000Z

    Explicit supersymmetry breaking is studied in higher dimensional theories by having boundaries respect only a subgroup of the bulk symmetry. If the boundary symmetry is the maximal subgroup allowed by the boundary conditions imposed on the fields, then the symmetry can be consistently gauged; otherwise gauging leads to an inconsistent theory. In a warped fifth dimension, an explicit breaking of all bulk supersymmetries by the boundaries is found to be inconsistent with gauging; unlike the case of flat 5D, complete supersymmetry breaking by boundary conditions is not consistent with supergravity. Despite this result, the low energy effective theory resulting from boundary supersymmetry breaking becomes consistent in the limit where gravity decouples, and such models are explored in the hope that some way of successfully incorporating gravity can be found. A warped constrained standard model leads to a theory with one Higgs boson with mass expected close to the experimental limit. A unified theory in a warped fifth dimension is studied with boundary breaking of both SU(5) gauge symmetry and supersymmetry. The usual supersymmetric predictionfor gauge coupling unification holds even though the TeV spectrum is quite unlike the MSSM. Such a theory may unify matter and Higgs in the same SU(5) hypermultiplet.

  12. Gel and process for preventing carbon dioxide break through

    SciTech Connect (OSTI)

    Sandiford, B.B.; Zillmer, R.C.

    1987-06-16T23:59:59.000Z

    A process is described for retarding the flow of carbon dioxide in carbon dioxide break-through fingers in a subterranean formation, the process comprising: (a) introducing a gas selected from the group consisting of carbon dioxide and gases containing carbon dioxide into a subterranean deposit containing carbon dioxide break-through fingers; (b) after the carbon dioxide break-through fingers have sorbed a predetermined amount of the gas, stopping the flow of the gas into the subterranean formation, (c) after stopping the flow of the gas into the subterranean formation, introducing an effective amount of a gel-forming composition into the subterranean formation and into the carbon dioxide break-through fingers, the gel-forming composition being operable, when contacting carbon dioxide break-through fingers containing the brine which has absorbed substantial amounts of carbon dioxide to form a gel in the fingers which is operable for retarding the flow of the gas in the finger. The gel-forming composition comprises: i. an aqueous solution comprising a first substance selected from the group consisting of polyvinyl alcohols, polyvinyl alcohol copolymers, and mixtures thereof, and ii. an amount of a second substance selected from the group consisting of aldehydes, aldehyde generating substances, acetals, acetal generating substances, and mixtures thereof.

  13. Using 3D Painting to Build and Repair Parts | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a part or add material to repair an existing part. Cold spray is part of GE's expanded additive manufacturing toolkit. An error occurred. Unable to execute Javascript. nteneh...

  14. Brain necrosis after fractionated radiation therapy: Is the halftime for repair longer than we thought?

    SciTech Connect (OSTI)

    Bender, Edward T. [Department of Human Oncology, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, Wisconsin 53792 (United States)

    2012-11-15T23:59:59.000Z

    Purpose: To derive a radiobiological model that enables the estimation of brain necrosis and spinal cord myelopathy rates for a variety of fractionation schemes, and to compare repair effects between brain and spinal cord. Methods: Sigmoidal dose response relationships for brain radiation necrosis and spinal cord myelopathy are derived from clinical data using nonlinear regression. Three different repair models are considered and the repair halftimes are included as regression parameters. Results: For radiation necrosis, a repair halftime of 38.1 (range 6.9-76) h is found with monoexponential repair, while for spinal cord myelopathy, a repair halftime of 4.1 (range 0-8) h is found. The best-fit alpha beta ratio is 0.96 (range 0.24-1.73)Conclusions: A radiobiological model that includes repair corrections can describe the clinical data for a variety of fraction sizes, fractionation schedules, and total doses. Modeling suggests a relatively long repair halftime for brain necrosis. This study suggests that the repair halftime for late radiation effects in the brain may be longer than is currently thought. If confirmed in future studies, this may lead to a re-evaluation of radiation fractionation schedules for some CNS diseases, particularly for those diseases where fractionated stereotactic radiation therapy is used.

  15. Application of break preclusion concept in German nuclear power plants

    SciTech Connect (OSTI)

    Roos, E. [Energie-Versorgung Schwaben AG, Stuttgart (Germany); Maier, V. [Bayernwerk AG, Muenchen (Germany); Nagel, G. [PraussenElektra AG, Hannover (Germany)] [and others

    1997-04-01T23:59:59.000Z

    The break preclusion concept is based on {open_quotes}KTA rules{close_quotes}, {open_quotes}RSK guidelines{close_quotes} and {open_quotes}Rahmenspeziflkation Basissicherheit{close_quotes}. These fundamental rules containing for example requirements on material, design, calculation, manufacturing and testing procedures are explained and the technical realisation is shown by means of examples. The proof of the quality of these piping systems can be executed by means of fracture mechanics calculations by showing that in every case the leakage monitoring system already detect cracks which are clearly smaller than the critical crack. Thus the leak before break behavior and the break preclusion concept is implicitly affirmed. In order to further diminish conservativities in the fracture mechanics procedures, specific research projects are executed which are explained in this contribution.

  16. Lorentz symmetry breaking as a quantum field theory regulator

    SciTech Connect (OSTI)

    Visser, Matt [School of Mathematics, Statistics, and Operations Research, Victoria University of Wellington, Wellington 6140 (New Zealand)

    2009-07-15T23:59:59.000Z

    Perturbative expansions of quantum field theories typically lead to ultraviolet (short-distance) divergences requiring regularization and renormalization. Many different regularization techniques have been developed over the years, but most regularizations require severe mutilation of the logical foundations of the theory. In contrast, breaking Lorentz invariance, while it is certainly a radical step, at least does not damage the logical foundations of the theory. I shall explore the features of a Lorentz symmetry breaking regulator in a simple polynomial scalar field theory and discuss its implications. In particular, I shall quantify just 'how much' Lorentz symmetry breaking is required to fully regulate the quantum theory and render it finite. This scalar field theory provides a simple way of understanding many of the key features of Horava's recent article [Phys. Rev. D 79, 084008 (2009)] on 3+1 dimensional quantum gravity.

  17. Break modeling for RELAP5 analyses of ISP-27 Bethsy

    SciTech Connect (OSTI)

    Petelin, S.; Gortnar, O.; Mavko, B.; Parzer, I.

    1992-01-01T23:59:59.000Z

    This paper presents pre- and posttest analyses of International Standard Problem (ISP) 27 on the Bethsy facility and separate RELAP5 break model tests considering the measured boundary condition at break inlet. This contribution also demonstrates modifications which have assured the significant improvement of model response in posttest simulations. Calculations were performed using the RELAP5/MOD2/36.05 and RELAP5/MOD3.5M5 codes on the MicroVAX, SUN, and CONVEX computers. Bethsy is an integral test facility that simulates a typical 900-MW (electric) Framatome pressurized water reactor. The ISP-27 scenario involves a 2-in. cold-leg break without HPSI and with delayed operator procedures for secondary system depressurization.

  18. Comparing Measured Fluorocarbon Leader Breaking Strength with Manufacturer Claims

    E-Print Network [OSTI]

    Haight, Christine; McQueeney, Kathleen; Courtney, Ya'el

    2012-01-01T23:59:59.000Z

    The experiment reported in this article addresses manufacturer claims of fluorocarbon leader material strength versus experimental tests of leaders strength. Breaking strength of fishing line is the most common specification when marketing fishing line. In this study, eight leaders rated near 15 pounds by their manufacturers were tested. Each leader was tested with a knot in the line and without a knot in the line. The strongest leader tested without a knot was Cabela's Seaguar fluorocarbon and the weakest leader tested without a knot was Cabela's Premier leader. The highest strength of leaders with a knot was the Ande Monofilament Fluorocarbon and the lowest breaking strength of leaders with a knot was the Seaguar Grand Max Fluorocarbon. Few published studies actually test the breaking strength of a leader to determine the accuracy of manufacturers' claims. Tensile strengths are also reported.

  19. Break-up stage restoration in multifragmentation reactions

    E-Print Network [OSTI]

    Ad. R. Raduta; E. Bonnet; B. Borderie; N. Le Neindre; S. Piantelli; M. F. Rivet

    2007-02-05T23:59:59.000Z

    In the case of Xe+Sn at 32 MeV/nucleon multifragmentation reaction break-up fragments are built-up from the experimentally detected ones using evaluations of light particle evaporation multiplicities which thus settle fragment internal excitation. Freeze-out characteristics are extracted from experimental kinetic energy spectra under the assumption of full decoupling between fragment formation and energy dissipated in different degrees of freedom. Thermal kinetic energy is determined uniquely while for freeze-out volume - collective energy a multiple solution is obtained. Coherence between the solutions of the break-up restoration algorithm and the predictions of a multifragmentation model with identical definition of primary fragments is regarded as a way to select the true value. The broad kinetic energy spectrum of $^3$He is consistent with break-up genesis of this isotope.

  20. Breaking anchored droplets in a microfluidic Hele-Shaw cell

    E-Print Network [OSTI]

    Amselem, Gabriel; Gallaire, François; Baroud, Charles N

    2015-01-01T23:59:59.000Z

    We study microfluidic self digitization in Hele-Shaw cells using pancake droplets anchored to surface tension traps. We show that above a critical flow rate, large anchored droplets break up to form two daughter droplets, one of which remains in the anchor. Below the critical flow velocity for breakup the shape of the anchored drop is given by an elastica equation that depends on the capillary number of the outer fluid. As the velocity crosses the critical value, the equation stops admitting a solution that satisfies the boundary conditions; the drop breaks up in spite of the neck still having finite width. A similar breaking event also takes place between the holes of an array of anchors, which we use to produce a 2D array of stationary drops in situ.

  1. Symmetry Breaking and False Vacuum Decay after Hybrid Inflation

    E-Print Network [OSTI]

    Juan Garcia-Bellido; Margarita Garcia Perez; Antonio Gonzalez-Arroyo

    2003-03-25T23:59:59.000Z

    We discuss the onset of symmetry breaking from the false vacuum in generic scenarios in which the mass squared of the symmetry breaking (Higgs) field depends linearly with time, as it occurs, via the evolution of the inflaton, in models of hybrid inflation. We show that the Higgs fluctuations evolve from quantum to classical during the initial stages. This justifies the subsequent use of real-time lattice simulations to describe the fully non-perturbative and non-linear process of symmetry breaking. The early distribution of the Higgs field is that of a smooth classical gaussian random field, and consists of lumps whose shape and distribution is well understood analytically. The lumps grow with time and develop into ``bubbles'' which eventually collide among themselves, thus populating the high momentum modes, in their way towards thermalization at the true vacuum. With the help of some approximations we are able to provide a quasi-analytic understanding of this process.

  2. Charge Symmetry Breaking and Parity Violating Electron-Proton Scattering

    E-Print Network [OSTI]

    Michael Wagman; Gerald A. Miller

    2014-12-16T23:59:59.000Z

    Charge symmetry breaking contributions to the proton's neutral weak form factors must be understood in order for future measurements of parity violating electron-proton scattering to be definitively interpreted as evidence of proton strangeness. We calculate these charge symmetry breaking form factor contributions using chiral perturbation theory with resonance saturation estimates for unknown low-energy constants. The uncertainty of the leading-order resonance saturation estimates is reduced by incorporating nuclear physics constraints. Higher-order contributions are investigated through phenomenological vertex form factors. We predict that charge symmetry breaking form factor contributions are an order of magnitude larger than expected from naive dimensional analysis but are still an order of magnitude smaller than current experimental bounds on proton strangeness. This is consistent with previous calculations using chiral perturbation theory with resonance saturation.

  3. Color breaking in the quantum leaped stop decay

    E-Print Network [OSTI]

    Imre Czovek

    2015-04-12T23:59:59.000Z

    The superfield propagator contains a measurable quantum leap, which comes from the definition of SUSY. In the sfermion -> Goldstino + fermion vertex change: 1. the spin of sparticle with discrete 1/2, 2. the Grassman superspace with the Goldstino shift operator. 3. the spacetime as the result of extra dimensional leap. The leap nature of SUSY transformations appears in the squark decay, it is the analog definition of SUSY. The quantum leaped outgoing propagators are determined and break locally the energy and the charge. Like to the teleportation the entangled pairs are here the b quark and the Goldstino. The dominant stop production is from gluons. The stop-antistop pair decay to quantum leaped b (c or t) quark, and the decay break the color. I get for the (color breaking) quantum leap: 10^-18 m !!! And 10^-11 m color breaking would be needed for a color breaking chain reaction. The open question is: Are the colliders going to produce supersymmetry charge? Because some charges in QGP can make long color breaking and a chain reaction. A long color broken QGP state in the re-Big Bang theory could explain the near infinite energy and the near infinite mass of the universe: - at first was random color QGP in the flat space-time, - at twice the color restoration in the curved space-time, which eats the Goldstinos, - and finally the baryon genesis. The re Big Bang make a supernova like collapse and a flat explosion of Universe. This explanation of SUSY hides the Goldstone fermion in the extra dimensions, the Goldstino propagate only in superspace and it is a not observable dark matter. PACS: 12.60.Jv

  4. A sociotechnical framework for understanding infrastructure breakdown and repair

    SciTech Connect (OSTI)

    Sims, Benjamin H [Los Alamos National Laboratory

    2009-01-01T23:59:59.000Z

    This paper looks at how and why infrastructure is repaired. With a new era of infrastructure spending underway, policymakers need to understand and anticipate the particular technical and political challenges posed by infrastructure repair. In particular, as infrastructure problems are increasingly in the public eye with current economic stimulus efforts, the question has increasingly been asked: why has it been so difficult for the United Statesto devote sustained resources to maintaining and upgrading its national infrastructure? This paper provides a sociotechnical framework for understanding the challenges of infrastructure repair, and demonstrates this framework using a case study of seismic retrofit of freeway bridges in California. The design of infrastructure is quite different from other types of design work even when new infrastructure is being designed. Infrastructure projects are almost always situated within, and must work with, existing infrastructure networks. As a result, compared to design of more discrete technological artifacts, the design of infrastructure systems requires a great deal of attention to interfaces as well as adaptation of design to the constraints imposed by existing systems. Also, because of their scale, infrastructural technologies engage with social life at a level where explicit political agendas may playa central role in the design process. The design and building of infrastructure is therefore often an enormously complex feat of sociotechnical engineering, in which technical and political agendas are negotiated together until an outcome is reached that allows the project to move forward. These sociotechnical settlements often result in a complex balancing of powerful interests around infrastructural artifacts; at the same time, less powerful interests have historically often been excluded or marginalized from such settlements.

  5. Repair welding of fusion reactor components. Final technical report

    SciTech Connect (OSTI)

    Chin, B.A.; Wang, C.A.

    1997-09-30T23:59:59.000Z

    The exposure of metallic materials, such as structural components of the first wall and blanket of a fusion reactor, to neutron irradiation will induce changes in both the material composition and microstructure. Along with these changes can come a corresponding deterioration in mechanical properties resulting in premature failure. It is, therefore, essential to expect that the repair and replacement of the degraded components will be necessary. Such repairs may require the joining of irradiated materials through the use of fusion welding processes. The present ITER (International Thermonuclear Experimental Reactor) conceptual design is anticipated to have about 5 km of longitudinal welds and ten thousand pipe butt welds in the blanket structure. A recent study by Buende et al. predict that a failure is most likely to occur in a weld. The study is based on data from other large structures, particularly nuclear reactors. The data used also appear to be consistent with the operating experience of the Fast Flux Test Facility (FFTF). This reactor has a fuel pin area comparable with the area of the ITER first wall and has experienced one unanticipated fuel pin failure after two years of operation. The repair of irradiated structures using fusion welding will be difficult due to the entrapped helium. Due to its extremely low solubility in metals, helium will diffuse and agglomerate to form helium bubbles after being trapped at point defects, dislocations, and grain boundaries. Welding of neutron-irradiated type 304 stainless steels has been reported with varying degree of heat-affected zone cracking (HAZ). The objectives of this study were to determine the threshold helium concentrations required to cause HAZ cracking and to investigate techniques that might be used to eliminate the HAZ cracking in welding of helium-containing materials.

  6. Margins in high temperature leak-before-break assessments

    SciTech Connect (OSTI)

    Budden, P.J.; Hooton, D.G.

    1997-04-01T23:59:59.000Z

    Developments in the defect assessment procedure R6 to include high-temperature mechanisms in Leak-before-Break arguments are described. In particular, the effect of creep on the time available to detect a leak and on the crack opening area, and hence leak rate, is discussed. The competing influence of these two effects is emphasized by an example. The application to Leak-before-Break of the time-dependent failure assessment diagram approach for high temperature defect assessment is then outlined. The approach is shown to be of use in assessing the erosion of margins by creep.

  7. Blade reliability collaborative : collection of defect, damage and repair data.

    SciTech Connect (OSTI)

    Ashwill, Thomas D.; Ogilvie, Alistair B.; Paquette, Joshua A.

    2013-04-01T23:59:59.000Z

    The Blade Reliability Collaborative (BRC) was started by the Wind Energy Technologies Department of Sandia National Laboratories and DOE in 2010 with the goal of gaining insight into planned and unplanned O&M issues associated with wind turbine blades. A significant part of BRC is the Blade Defect, Damage and Repair Survey task, which will gather data from blade manufacturers, service companies, operators and prior studies to determine details about the largest sources of blade unreliability. This report summarizes the initial findings from this work.

  8. Rebels, Activists, and Repairers: Youth and Social Change in Africa

    E-Print Network [OSTI]

    Pollock, Colleen

    2011-12-31T23:59:59.000Z

    #3;answer#3;questions#3; (Irvine#3;1978)#3;(i.e.#3;?“what#3;does#3;the#3;ducky#3;say??”)#3;because#3;such#3;questioning#3;indicates#3;a#3;riddle#3;with#3; a#3;trick#3;answer#3;or#3;a#3;direct#3;challenge,#3;and#3;it#3;is#3;considered#3;an#3;insult#3... Date Defended: May 17, 2011 #3; #3; #3; #3; #3; #3; ii #3; The Thesis Committee for Colleen Pollock certifies that this is the approved version of the following thesis: REBELS, ACTIVISTS, AND REPAIRERS: THE ROLE OF YOUTH IN SOCIAL CHANGE...

  9. Repairs for damaged bolt holes in continuous fiber reinforced plastics

    E-Print Network [OSTI]

    Copps, Kevin Daniel

    1992-01-01T23:59:59.000Z

    ANALYSIS Model Definition Analysis Results Comparing Lay-ups Pin-conditions vs. clamping pressure Stress interactions Repair material CONCLUSIONS REFERENCES APPENDIX VITA 21 22 23 24 25 25 25 26 27 27 28 29 30 30 31 33 33 34 34... under pin conditions . 35 16 A modification was made to the test fixture to relieve the high cyclic stresses on the bolt 37 vu 17 When clamping pressure is applied, a normally drilled, unrepaired, fastener hole is stronger and tends to fail in net...

  10. ADVERTISMENT Home > News > Breaking news 20 May 2009

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    ADVERTISMENT Home > News > Breaking news 20 May 2009 New tool for next-generation cancer treatments 2 of 2 Prostate Cancer Options Most advanced prostate cancer treatments in Chicago's NW suburbs www.nch.org/northwestcommunityhosp New Cancer Treatments Discover The 12 Most Effective Cancer Treatments In Existence! Ultimate-Cancer

  11. Structural Testing at the Micro and Nano Scales: Breaking

    E-Print Network [OSTI]

    Ballarini, Roberto

    Structural Testing at the Micro and Nano Scales: Breaking Invisible Specimens With Zero Force). "Nano measurements with micro devices: mechanical properties of hydrated collagen fibrils," J. of the R tangential slots · Fuel swirls in the spin chamber and exits through the orifice in a hollow conical spray

  12. EasyVoice: Breaking barriers for people with voice disabilities

    E-Print Network [OSTI]

    Condado, Paulo

    disabilities. With the advances in computing power, new applications have been developed for helping peopleEasyVoice: Breaking barriers for people with voice disabilities Paulo A. Condado and Fernando G,flobo}@ualg.pt Abstract. Text-to-speech technology has been broadly used to help people with voice disabilities

  13. Building Cathedrals and Breaking down Reinforced Concrete Walls

    E-Print Network [OSTI]

    Broué, Michel - Institut de Mathématiques de Jussieu, Université Paris 7

    Building Cathedrals and Breaking down Reinforced Concrete Walls Michel Brou´e Institut Henri distinction between great mathematicians Concrete walls breakers Michel Brou´e (Institut Henri Poincar´e) John Concrete walls breakers Cathedrals builders Michel Brou´e (Institut Henri Poincar´e) John Thompson

  14. Bootstrap Dynamical Symmetry Breaking with New Heavy Chiral Quarks

    E-Print Network [OSTI]

    Yukihiro Mimura; Wei-Shu Hou; Hiroaki Kohyama

    2013-01-31T23:59:59.000Z

    A Higgs-like new boson with mass around 126 GeV is now established, but its true nature probably cannot be settled with 2011--2012 LHC data. We assume it is a dilaton with couplings weaker than the Higgs boson (except to $\\gamma\\gamma$ and $gg$), and explore dynamical symmetry breaking (DSB) by strong Yukawa coupling of a yet unseen heavy chiral quark doublet $Q$. Assuming the actual Higgs boson to be heavy, the Goldstone boson $G$ of electroweak symmetry breaking still couples to $Q$ with Yukawa coupling $\\lambda_Q$. A ``bootstrap" gap equation without a Higgs particle is constructed. Electroweak symmetry breaking via strong $\\lambda_Q$ generates both heavy mass for $Q$, while self-consistently justifying $G$ as a massless Goldstone particle in the loop. The spontaneous breaking of scale invariance in principle \\emph{allows} for a dilaton. We numerically solve such a gap equation and find the mass of the heavy quark to be a couple of TeV. We offer a short critique on the results of the scale-invariant model of Hung and Xiong, where a similar gap equation is built with a massless scalar doublet. Through this we show that a light SM Higgs at 126 GeV cannot be viable within our approach to DSB, while a dilaton with weaker couplings is consistent with our main result.

  15. BREAKING WITH OR BUILDING ON THE PAST? REFORMING IRISH PUBLIC

    E-Print Network [OSTI]

    of the application of new public management styles to Ireland. Particular attention is paid to the public serviceBREAKING WITH OR BUILDING ON THE PAST? REFORMING IRISH PUBLIC ADMINISTRATION: 1958-2008 Niamh? REFORMING IRISH PUBLIC ADMINISTRATION: 1958-2008 Niamh Hardiman and Muiris MacCarthaigh Working Papers

  16. Mechanisms of cellular symmetry breaking in S. cerevisiae

    E-Print Network [OSTI]

    Smith, Sarah Ellen

    2013-12-31T23:59:59.000Z

    ………………… … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … …..1 Chapter 2: Non ?uniform membrane diffusion enables steady?state cell polarization via vesicular trafficking………………………… … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … …..34 Chapter 3: Independence of symmetry breaking on... Bem1?mediated autocatalytic activation of Cdc42……………………… … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … … ….88 Chapter 4: Preliminary data on Cdc42 microdomains in the presence of Rdi1 feedback………..135 Chapter 5...

  17. Vacuum condensates, flavor mixing and spontaneous supersymmetry breaking

    E-Print Network [OSTI]

    Antonio Capolupo; Marco Di Mauro

    2013-01-05T23:59:59.000Z

    Spontaneous supersymmetry (SUSY) breaking is revealed in all phenomena in which vacuum condensates are physically relevant. The dynamical breakdown of SUSY is generated by the condensates themselves, which lift the zero point energy. Evidence is presented in the case of the Wess-Zuimino model, and the flavor mixing case is treated in detail.

  18. Timber + TouchPads: How Education Will Make or Break

    E-Print Network [OSTI]

    Pulfrey, David L.

    Timber + TouchPads: How Education Will Make or Break BC's Emerging Smart Economy Vancouver Board the health of the soil and human health and survival. Right here at home, Business in Vancouver founder Peter-wide collective of farmers' markets. The BC government just announced $2 million dollars in funding for local food

  19. Researcher breaks new ground in understanding chemical reaction process

    E-Print Network [OSTI]

    Glaser, Rainer

    Researcher breaks new ground in understanding chemical reaction process Study of diazonium rewrites about a common, basic chemical process using diazonium ions as the example. These ions are used in nature. Now, a professor of chemistry has found that this chemical process has been incorrectly described

  20. Repairs to silence Tower bells | The Daily Texan http://dailytexanonline.com/news/2012/09/27/repairs-to-silence-tower-bells 2 of 4 10/2/2012 8:55 AM

    E-Print Network [OSTI]

    John, Lizy Kurian

    Repairs to silence Tower bells | The Daily Texan http://dailytexanonline.com/news/2012/09/27/repairs-to-silence-tower-bells 2 of 4 10/2/2012 8:55 AM #12;Repairs to silence Tower bells | The Daily Texan http://dailytexanonline.com/news/2012/09/27/repairs-to-silence-tower-bells 3 of 4 10/2/2012 8

  1. Cooperative Repair with Minimum-Storage Regenerating Codes for Distributed Storage

    E-Print Network [OSTI]

    Li, Baochun

    Cooperative Repair with Minimum-Storage Regenerating Codes for Distributed Storage Jun Li, Baochun--Distributed storage systems store redundant data to tolerate failures of storage nodes and lost data should be repaired when storage nodes fail. A class of MDS codes, called minimum- storage regenerating (MSR) codes

  2. 4 CONCRETE REPAIR BULLETIN MAY/JUNE2001 Laser Profilometry for

    E-Print Network [OSTI]

    Maerz, Norbert H.

    4 CONCRETE REPAIR BULLETIN MAY/JUNE2001 Laser Profilometry for Concrete Substrate Characterization and resins are non- corrosive, they are ideally suited for the repair and retrofitting of concrete bridges highly upon the quality of the bond between the concrete and the laminate. Experience has shown that when

  3. On the Design of an Interactive, Patient-Specific Surgical Simulator for Mitral Valve Repair

    E-Print Network [OSTI]

    On the Design of an Interactive, Patient-Specific Surgical Simulator for Mitral Valve Repair Neil A repair of the mitral valve is a difficult procedure that is often avoided in favor of less effective valve replacement because of the associated technical challenges facing non-expert surgeons

  4. Bridge Damage and Repair Costs from Hurricane Katrina Jamie Padgett1

    E-Print Network [OSTI]

    Padgett, Jamie Ellen

    Bridge Damage and Repair Costs from Hurricane Katrina Jamie Padgett1 ; Reginald DesRoches2 ; Bryant caused significant damage to the transportation system in the Gulf Coast region. The overall cost to repair or replace the bridges damaged during the hurricane is estimated at over $1 billion. This paper

  5. Automatic Repair of Buggy If Conditions and Missing Preconditions with SMT

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Automatic Repair of Buggy If Conditions and Missing Preconditions with SMT Favio De into a Satisfiability Modulo Theory (SMT) problem, and translating the SMT result ­ if there exists one ­ into a source, Verification Keywords Automatic repair, test suite, buggy if condition, missing pre- condition, SMT, angelic

  6. Bone Marrow Stimulation of the Medial Femoral Condyle Produces Inferior Cartilage and Bone Repair Compared to the Trochlea in a

    E-Print Network [OSTI]

    Buschmann, Michael

    Bone Marrow Stimulation of the Medial Femoral Condyle Produces Inferior Cartilage and Bone Repair femoral condylar (MFC) versus femoral trochlear (TR) defects 3 months after bone marrow stimulation: cartilage repair; medial femoral condyle; trochlea; bone marrow stimulation; meniscus degeneration Articular

  7. ITERATIVE REPAIR PLANNING FOR SPACECRAFT OPERATIONS USING THE ASPEN SYSTEM Gregg Rabideau, Russell Knight, Steve Chien, Alex Fukunaga, Anita Govindjee

    E-Print Network [OSTI]

    Schaffer, Steven

    ITERATIVE REPAIR PLANNING FOR SPACECRAFT OPERATIONS USING THE ASPEN SYSTEM Gregg Rabideau, Russell and Planning Environment (ASPEN). ASPEN encodes complex spacecraft knowledge of operability constraints, flight generation of low level spacecraft sequences. Using a technique called iterative repair, ASPEN classifies

  8. Injection repair of carbon fiber/bismaleimide composite panels with bisphenol E cyanate ester resin

    SciTech Connect (OSTI)

    Thunga, Mahendra [Ames Laboratory; Bauer, Amy [Iowa State University; Obusek, Kristine [Fleet Readiness Center East; Meilunas, Ray [Naval Air Warfare Center Aircraft Division; Akinc, Mufit [Ames Laboratory; Kessler, Michael R [Ames Laboratory

    2014-08-01T23:59:59.000Z

    Resin injection of bisphenol E cyanate ester, a low viscosity resin that cures into a high temperature thermoset polymer, is investigated as a reliable repair method to restore strength and stiffness in delaminated carbon fiber/bismaleimide composites used in aircraft panels. The influence of temperature on the viscosity of the uncured resin was measured to optimize the injection conditions for high resin infiltration into the delaminations. The repair efficiency of the resin was evaluated by varying the panel thickness and the method by which the delamination damage was created in the composite specimens. Ultrasonic scanning (C-scan), flash thermography images, and cross-section analysis of repaired panels revealed excellent resin infiltration into the damaged region. Evaluation of mechanical repair efficiency using both bending stiffness and in-plain compressive strength of the composite panels as the repair metrics showed values exceeding 100%.

  9. Repair of gamma-ray-induced DNA base damage in xeroderma pigmentosum cells

    SciTech Connect (OSTI)

    Fornace, A.J. Jr.; Dobson, P.P.; Kinsella, T.J.

    1986-04-01T23:59:59.000Z

    The repair of DNA damage produced by /sup 137/Cs gamma irradiation was measured with a preparation from Micrococcus luteus containing DNA damage-specific endonucleases in combination with alkaline elution. The frequency of these endonuclease sensitive sites (ESS) was determined after 54 or 110 Gy of oxic irradiation in normal and xeroderma pigmentosum (XP) fibroblasts from complementation groups A, C, D, and G. Repair was rapid in all cell strains with greater than 50% repair after 1.5 h of repair incubation. At later repair times, 12-17 h, more ESS remained in XP than in normal cells. The frequency of excess ESS in XP cells was approximately 0.04 per 10(9) Da of DNA per Gy which was equivalent to 10% of the initial ESS produced. The removal of ESS was comparable in XP cells with normal radiosensitivity and XP3BR cells which have been reported to be moderately radiosensitive.

  10. FastFEM: Breaking Wave Impact on Ships Wave breaking and wave impact on maritime structures are difficult to model

    E-Print Network [OSTI]

    Wirosoetisno, Djoko

    are difficult to model mathematically and numerically. The challenge is that nonlinear and breaking waves with fine-scale dynamic air-water interfaces need to be modelled efficiently, including their interactions measurements in wave basins. These potential flow models will be developed further at the University of Twente

  11. 1Banff 6/06 Structural Break Detection in Time Series ModelsStructural Break Detection in Time Series Models

    E-Print Network [OSTI]

    breaks in this series? #12;5Banff 6/06 Introduction Examples AR GARCH Stochastic volatility State space Simulation results Applications Simulation results for GARCH and SV models #12;6Banff 6/06 Examples 1 ),,( 1 jjpj K #12;7Banff 6/06 Examples (cont) 2. Segmented GARCH model: where 0 = 1

  12. Method of tissue repair using a composite material

    DOE Patents [OSTI]

    Hutchens, Stacy A; Woodward, Jonathan; Evans, Barbara R; O'Neill, Hugh M

    2014-03-18T23:59:59.000Z

    A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

  13. Navier-Stokes simulations of steep breaking water waves with a coupled air-water interface

    E-Print Network [OSTI]

    Hendrickson, Kelli L

    2005-01-01T23:59:59.000Z

    Wave breaking on the ocean surface significantly facilitates the transfer of mass, momentum, heat and energy across the air-sea interface. In the context of the near field flow about a surface ship, the breaking bow wave ...

  14. Coastal Wave Generation and Wave Breaking over Terrain: Two Problems in Mesoscale Wave Dynamics 

    E-Print Network [OSTI]

    Qian, Tingting

    2010-07-14T23:59:59.000Z

    Two problems in mesoscale wave dynamics are addressed: (i) wave-turbulence interaction in a breaking mountain wave and (ii) gravity wave generation associated with coastal heating gradients. The mean and turbulent structures in a breaking mountain...

  15. Quantitative imaging of the air-water flow fields formed by unsteady breaking waves

    E-Print Network [OSTI]

    Belden, Jesse (Jesse Levi)

    2009-01-01T23:59:59.000Z

    An experimental method for simultaneously measuring the velocity fields on the air and water side of unsteady breaking waves is presented. The method is applied to breaking waves to investigate the physics of the air and ...

  16. Experimental investigation of small-scale breaking waves : flow visualization across the air-water interface

    E-Print Network [OSTI]

    McDonald, Angus Kai

    2005-01-01T23:59:59.000Z

    The dynamics of breaking waves significantly affect air-sea fluxes of heat, momentum, mass and energy across the ocean interface. Breaking waves also contribute considerable loading to offshore and coastal structures, and ...

  17. Three dimensional effects in analysis of PWR steam line break accident

    E-Print Network [OSTI]

    Tsai, Chon-Kwo

    A steam line break accident is one of the possible severe abnormal transients in a pressurized water reactor. It is required to present an analysis of a steam line break accident in the Final Safety Analysis Report (FSAR) ...

  18. U.S. Department of Energy Breaks Ground on State-of-the-Art Wind...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    U.S. Department of Energy Breaks Ground on State-of-the-Art Wind Turbine Test Facility U.S. Department of Energy Breaks Ground on State-of-the-Art Wind Turbine Test Facility...

  19. Coastal Wave Generation and Wave Breaking over Terrain: Two Problems in Mesoscale Wave Dynamics

    E-Print Network [OSTI]

    Qian, Tingting

    2010-07-14T23:59:59.000Z

    Two problems in mesoscale wave dynamics are addressed: (i) wave-turbulence interaction in a breaking mountain wave and (ii) gravity wave generation associated with coastal heating gradients. The mean and turbulent structures in a breaking mountain...

  20. Neurological Complications Following Endoluminal Repair of Thoracic Aortic Disease

    SciTech Connect (OSTI)

    Morales, J. P.; Taylor, P. R.; Bell, R. E.; Chan, Y. C. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Sabharwal, T. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom); Carrell, T. W. G. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Reidy, J. F. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom)], E-mail: John.Reidy@gstt.nhs.uk

    2007-09-15T23:59:59.000Z

    Open surgery for thoracic aortic disease is associated with significant morbidity and the reported rates for paraplegia and stroke are 3%-19% and 6%-11%, respectively. Spinal cord ischemia and stroke have also been reported following endoluminal repair. This study reviews the incidence of paraplegia and stroke in a series of 186 patients treated with thoracic stent grafts. From July 1997 to September 2006, 186 patients (125 men) underwent endoluminal repair of thoracic aortic pathology. Mean age was 71 years (range, 17-90 years). One hundred twenty-eight patients were treated electively and 58 patients had urgent procedures. Anesthesia was epidural in 131, general in 50, and local in 5 patients. Seven patients developed paraplegia (3.8%; two urgent and five elective). All occurred in-hospital apart from one associated with severe hypotension after a myocardial infarction at 3 weeks. Four of these recovered with cerebrospinal fluid (CSF) drainage. One patient with paraplegia died and two had permanent neurological deficit. The rate of permanent paraplegia and death was 1.6%. There were seven strokes (3.8%; four urgent and three elective). Three patients made a complete recovery, one had permanent expressive dysphasia, and three died. The rate of permanent stroke and death was 2.1%. Endoluminal treatment of thoracic aortic disease is an attractive alternative to open surgery; however, there is still a risk of paraplegia and stroke. Permanent neurological deficits and death occurred in 3.7% of the patients in this series. We conclude that prompt recognition of paraplegia and immediate insertion of a CSF drain can be an effective way of recovering spinal cord function and improving the prognosis.

  1. The Environmental Impact of Lyman-break Galaxies

    E-Print Network [OSTI]

    Elizabeth J. Tasker; Greg L. Bryan

    2006-04-11T23:59:59.000Z

    We perform cosmological simulations of galaxies forming at z=3 using the hydrodynamics grid code, Enzo. By selecting the largest galaxies in the volume to correspond to Lyman-break galaxies, we construct observational spectra of the HI flux distribution around these objects, as well as column densities of CIV and OVI throughout a refined region. We successfully reproduce the most recent observations of the mean HI flux in the close vicinity of Lyman-break galaxies but see no evidence for the proximity effect in earlier observations. While our galaxies do return metals to the IGM, their quantity and volume appears to be somewhat less than observed. We conclude that either we do not adequately resolve galactic winds, or that at least some of the intergalactic metal enrichment is by early epoch objects whose mass is smaller than our minimum resolved halo mass.

  2. Breaking discrete symmetries in the effective field theory of inflation

    E-Print Network [OSTI]

    Dario Cannone; Jinn-Ouk Gong; Gianmassimo Tasinato

    2015-05-29T23:59:59.000Z

    We study the phenomenon of discrete symmetry breaking during the inflationary epoch, using a model-independent approach based on the effective field theory of inflation. We work in a context where both time reparameterization symmetry and spatial diffeomorphism invariance can be broken during inflation. We determine the leading derivative operators in the quadratic action for fluctuations that break parity and time-reversal. Within suitable approximations, we study their consequences for the dynamics of linearized fluctuations. Both in the scalar and tensor sectors, we show that such operators can lead to new direction-dependent phases for the modes involved. They do not affect the power spectra, but can have consequences for higher correlation functions. Moreover, a small quadrupole contribution to the sound speed can be generated.

  3. Pipe break frequency estimation for Nuclear Power Plants

    SciTech Connect (OSTI)

    Wright, R.E.; Steverson, J.A.; Zuroff, W.F.

    1987-05-01T23:59:59.000Z

    This study empirically develops frequencies of safety-significant pipe failures in commercial nuclear power plants (NPPs). Its primary purpose is to update the pipe break frequencies reported in the Reactor Safety Study, WASH-1400, which are used in many risk analyses. The study involved reviewing various data sources for actual piping failure events of significant magnitude. When extant in the documentation reviewed, information was extracted concerning conditional factors such as the system in which the failure occurred, operational mode of the plant, and size of the pipe involved to estimate conditional pipe break frequencies useful to risk analysts. Because of the high quality piping used in NPPs, there have been few significant pipe failures. An attempt was made to augment the analysis with synthetic data from a Delphi approach, but the wide uncertainty bounds on the resulting estimates rendered the results unsuitable for combining data.

  4. Density driven symmetry breaking and Butterfly effect in holographic superconductors

    E-Print Network [OSTI]

    Youngman Kim; Yumi Ko; Sang-Jin Sin

    2009-12-01T23:59:59.000Z

    We study the density driven symmetry breaking in holographic superconductors by considering the positive mass squared case. We show that even for the positive $m^2$, a scalar condensation still forms, provided the chemical potential is high enough. As $m^2$ increases, the phase space folds due to the non-linearity of the equations of motion, and two nearby points in the phase space can represent symmetry breaking and preserving configurations respectively. The phase space defined by the set of initial conditions of field variables at the horizon undergoes a non-linear radial evolution to result in the phase space folding, a characteristic phenomenon in a non-linear system. We then calculate the specific heat, which characterizes superconductors and has been measured in experiments.We observe a discontinuity in the specific heat at the transition point and compare our results with experimentally observed numbers. The electrical conductivity for various $m^2$ is also calculated.

  5. A Gravity Dual of Metastable Dynamical Supersymmetry Breaking

    SciTech Connect (OSTI)

    DeWolfe, Oliver; /Colorado U.; Kachru, Shamit; Mulligan, Michael; /Stanford U., Phys. Dept. /SLAC

    2008-02-04T23:59:59.000Z

    Metastable, supersymmetry-breaking configurations can be created in flux geometries by placing antibranes in warped throats. Via gauge/gravity duality, such configurations should have an interpretation as supersymmetry-breaking states in the dual field theory. In this paper, we perturbatively determine the asymptotic supergravity solutions corresponding to D3-brane probes placed at the tip of the cascading warped deformed conifold geometry, which is dual to an SU(N+M) x SU(N) gauge theory. The backreaction of the antibranes has the effect of introducing imaginary anti-self-dual flux, squashing the compact part of the space and forcing the dilaton to run. Using the generalization of holographic renormalization to cascading geometries, we determine the expectation values of operators in the dual field theory in terms of the asymptotic values of the supergravity fields.

  6. Electroweak Symmetry Breaking without the $\\mu^2$ Term

    E-Print Network [OSTI]

    Goertz, Florian

    2015-01-01T23:59:59.000Z

    We demonstrate that from a low energy perspective a viable electroweak symmetry breaking can be achieved without the (negative sign) $\\mu^2$ mass term in the Higgs potential, thereby avoiding completely the appearance of relevant operators. We show that such a setup is self consistent and not ruled out by Higgs physics. In particular, we point out that it is the lightness of the Higgs boson that allows for the electroweak symmetry to be broken dynamically via operators of $D\\geq 4$, consistent with the power expansion. Beyond that, we entertain how this scenario might even be preferred phenomenologically compared to the ordinary mechanism of electroweak symmetry breaking, as realized in the Standard Model, and argue that it can be fully tested at the LHC. In an appendix, we classify UV completions that could lead to such a setup, considering also the option of generating all scales dynamically.

  7. Development and validation of bonded composite doubler repairs for commercial aircraft.

    SciTech Connect (OSTI)

    Roach, Dennis Patrick; Rackow, Kirk A.

    2007-07-01T23:59:59.000Z

    A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack, impact, and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safely extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC), Boeing, and Federal Express completed a pilot program to validate and introduce composite doubler repair technology to the U.S. commercial aircraft industry. This project focused on repair of DC-10 fuselage structure and its primary goal was to demonstrate routine use of this repair technology using niche applications that streamline the design-to-installation process. As composite doubler repairs gradually appear in the commercial aircraft arena, successful flight operation data is being accumulated. These commercial aircraft repairs are not only demonstrating the engineering and economic advantages of composite doubler technology but they are also establishing the ability of commercial maintenance depots to safely adopt this repair technique. This report presents the array of engineering activities that were completed in order to make this technology available for widespread commercial aircraft use. Focused laboratory testing was conducted to compliment the field data and to address specific issues regarding damage tolerance and flaw growth in composite doubler repairs. Fatigue and strength tests were performed on a simulated wing repair using a substandard design and a flawed installation. In addition, the new Sol-Gel surface preparation technique was evaluated. Fatigue coupon tests produced Sol-Gel results that could be compared with a large performance database from conventional, riveted repairs. It was demonstrated that not only can composite doublers perform well in severe off-design conditions (low doubler stiffness and presence of defects in doubler installation) but that the Sol-Gel surface preparation technique is easier and quicker to carry out while still producing optimum bonding properties. Nondestructive inspection (NDI) methods were developed so that the potential for disbond and delamination growth could be monitored and crack growth mitigation could be quantified. The NDI methods were validated using full-scale test articles and the FedEx aircraft installations. It was demonstrated that specialized NDI techniques can detect flaws in composite doubler installations before they reach critical size. Probability of Detection studies were integrated into the FedEx training in order to quantify the ability of aircraft maintenance depots to properly monitor these repairs. In addition, Boeing Structural Repair and Nondestructive Testing Manuals were modified to include composite doubler repair and inspection procedures. This report presents the results from the FedEx Pilot Program that involved installation and surveillance of numerous repairs on operating aircraft. Results from critical NDI evaluations are reported in light of damage tolerance assessments for bonded composite doublers. This work has produced significant interest from airlines and aircraft manufacturers. The successful Pilot Program produced flight performance history to establish the durability of bonded composite patches as a permanent repair on commercial aircraft structures. This report discusses both the laboratory data and Pilot Program results from repair installations on operating aircraft to introduce composite doubler repairs into mainstream commercial aircraft use.

  8. Effect of multiple repairs in girth welds of pipelines on the mechanical properties

    SciTech Connect (OSTI)

    Vega, O.E.; Hallen, J.M. [Departamento de Ingenieria Metalurgica, ESIQIE-IPN, Laboratorios Pesados de Metalurgia, UPALM, Zacatenco, C.P. 07738, Mexico D.F. (Mexico); Villagomez, A. [Construcciones Maritimas Mexicanas, CMM-PROTEXA, Av. Periferica s/n, Fracc. Lomas de Holche, C.P. 24120, Cd. del Carmen, Campeche (Mexico); Contreras, A. [Instituto Mexicano del Petroleo, Investigacion en Ductos, Corrosion y Materiales, Eje Central Lazaro Cardenas Norte 152 Col. San Bartolo Atepehuacan, C.P. 07730, Mexico D.F. (Mexico)], E-mail: acontrer@imp.mx

    2008-10-15T23:59:59.000Z

    This work presents the results of multiple weld repairs in the same area in seamless API X-52 microalloyed steel pipe. Four conditions of shielded metal arc welding repairs and one as-welded specimen of the girth weld were characterized to determine changes in the microstructure, grain size in the heat affected zone, and to evaluate their effect on the mechanical properties of the weld joints. The mechanical properties by means of tension tests, Charpy-V impact resistance and Vickers hardness of the welds were analyzed. The results indicate that significant changes are not generated in the microstructural constituents of the heat affected zone. Grain growth in the heat affected zone at the specimen mid-thickness with the number of repairs was observed. Tensile strength of the weld joints meets the requirement of the API 1104 standard even after the fourth weld repair. Significant reduction in Charpy-V impact resistance with the number of weld repairs was found when the notch location was in the intersection of the fusion line with the specimen mid-thickness. A significant increase in the Vickers hardness of the heat affected zone occurred after the first repair and a gradual decrease in the Vickers hardness occurred as the number of repairs increases.

  9. Fabrication Flaw Density and Distribution In Repairs to Reactor Pressure Vessel and Piping Welds

    SciTech Connect (OSTI)

    GJ Schuster, FA Simonen, SR Doctor

    2008-04-01T23:59:59.000Z

    The Pacific Northwest National Laboratory is developing a generalized fabrication flaw distribution for the population of nuclear reactor pressure vessels and for piping welds in U.S. operating reactors. The purpose of the generalized flaw distribution is to predict component-specific flaw densities. The estimates of fabrication flaws are intended for use in fracture mechanics structural integrity assessments. Structural integrity assessments, such as estimating the frequency of loss-of-coolant accidents, are performed by computer codes that require, as input, accurate estimates of flaw densities. Welds from four different reactor pressure vessels and a collection of archived pipes have been studied to develop empirical estimates of fabrication flaw densities. This report describes the fabrication flaw distribution and characterization in the repair weld metal of vessels and piping. This work indicates that large flaws occur in these repairs. These results show that repair flaws are complex in composition and sometimes include cracks on the ends of the repair cavities. Parametric analysis using an exponential fit is performed on the data. The relevance of construction records is established for describing fabrication processes and product forms. An analysis of these records shows there was a significant change in repair frequency over the years when these components were fabricated. A description of repair flaw morphology is provided with a discussion of fracture mechanics significance. Fabrication flaws in repairs are characterized using optimized-access, high-sensitivity nondestructive ultrasonic testing. Flaw characterizations are then validated by other nondestructive evaluation techniques and complemented by destructive testing.

  10. RR Flux on Calabi-Yau and Partial Supersymmetry Breaking

    E-Print Network [OSTI]

    T. R. Taylor; C. Vafa

    2000-01-26T23:59:59.000Z

    We show how turning on Flux for RR (and NS-NS) field strengths on non-compact Calabi-Yau 3-folds can serve as a way to partially break supersymmetry from N=2 to N=1 by mass deformation. The freezing of the moduli of Calabi-Yau in the presence of the flux is the familiar phenomenon of freezing of fields in supersymmetric theories upon mass deformations.

  11. Gauge/gravity Duality and MetastableDynamical Supersymmetry Breaking

    SciTech Connect (OSTI)

    Argurio, Riccardo; Bertolini, Matteo; Franco, Sebastian; Kachru, Shamit

    2006-10-24T23:59:59.000Z

    We engineer a class of quiver gauge theories with several interesting features by studying D-branes at a simple Calabi-Yau singularity. At weak 't Hooft coupling we argue using field theory techniques that these theories admit both supersymmetric vacua and meta-stable non-supersymmetric vacua, though the arguments indicating the existence of the supersymmetry breaking states are not decisive. At strong 't Hooft coupling we find simple candidate gravity dual descriptions for both sets of vacua.

  12. S-Dual Gaugino Condensation and Supersymmetry Breaking

    E-Print Network [OSTI]

    Z. Lalak; A. Niemeyer; H. P. Nilles

    1994-10-27T23:59:59.000Z

    The principle of S-duality is used to incorporate gaugino condensates into effective supergravity (superstring) Lagrangians. We discuss two implementations of S-duality which differ in the way the coupling constant is transformed. Both solve the problem of the runaway dilaton and lead to satisfactory supersymmetry breaking in models with a {\\em single} gaugino condensate. The breakdown of supersymmetry is intimately related to a nontrivial transformation of the condensate under T-duality.

  13. Selected Bibliography on Electric Motor Repair | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreakingMay 2015ParentsMiddle|Security Enforcement Documentsis NotSelect

  14. Leveraging Service Calls and Emergency Repairs for Energy Efficiency

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking ofOil & Gas »ofMarketing | Department of Energy Service Calls and

  15. Inspect and Repair Steam Traps | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking of BlytheDepartment ofEnergy InformationSavings for

  16. Solar Water Heating System Maintenance and Repair | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreakingMayDepartment of EnergySite Screening Decision Tree SolarSolar Water

  17. FLASH predictions of the MB-2 steam line break tests

    SciTech Connect (OSTI)

    Lincoln, F.W.; Coffield, R.D.; Johnson, E.G.

    1992-12-31T23:59:59.000Z

    If a main steam line from a pressurized water reactor (PWR) steam generator were to rupture, the effect would be a depressurization of the secondary side and a consequential overcooling transient on the primary side. Analyses must accurately predict the effects of the rapid cooldown of the reactor vessel coolant on positive nuclear-kinetic reactivity feedback to the core plus thermal shock to the reactor vessel and other primary system components. Many early studies of the steam line break (SLB) transient made extremely conservative assumptions to maximize the primary to secondary heat transfer which in turn maximized the reactor vessel cooldown rate. Among the more significant of these assumptions was that flow from the break was pure steam and that the tube bundle remained covered until the secondary mass inventory was significantly reduced. The Model F commercial PWR steam generator testing performed in the Model Boiler No. 2 (MB-2) facility located at the Westinghouse Engineering Test Facility in Tampa, Florida provided data to better qualify the actual variation in these key parameters. A conclusion of this analysis is that the MB-2 steam line break data base is accurate and of sufficient detail to provide a valuable basis for making comparisons relative to code predictions. Results obtained using the FLASH transient safety analysis code were found to be in excellent agreement with the data.

  18. Peccei-Quinn Symmetry from Dynamical Supersymmetry Breaking

    E-Print Network [OSTI]

    Harigaya, Keisuke; Schmitz, Kai; Yanagida, Tsutomu T

    2015-01-01T23:59:59.000Z

    The proximity of the Peccei-Quinn scale to the scale of supersymmetry breaking in models of pure gravity mediation hints at a common dynamical origin of these two scales. To demonstrate how to make such a connection manifest, we embed the Peccei-Quinn mechanism into the vector-like model of dynamical supersymmetry breaking a la IYIT. Here, we rely on the anomaly-free discrete Z4R symmetry required in models of pure gravity mediation to solve the mu problem to protect the Peccei-Quinn symmetry from the dangerous effect of higher-dimensional operators. This results in a rich phenomenology featuring a QCD axion with a decay constant of O(10^10) GeV and mixed WIMP/axion dark matter. In addition, exactly five pairs of extra 5 and 5* matter multiplets, directly coupled to the supersymmetry breaking sector and with masses close to the gravitino mass, m3/2 ~ 100 TeV, are needed to cancel the Z4R anomalies.

  19. Peccei-Quinn Symmetry from Dynamical Supersymmetry Breaking

    E-Print Network [OSTI]

    Keisuke Harigaya; Masahiro Ibe; Kai Schmitz; Tsutomu T. Yanagida

    2015-05-27T23:59:59.000Z

    The proximity of the Peccei-Quinn scale to the scale of supersymmetry breaking in models of pure gravity mediation hints at a common dynamical origin of these two scales. To demonstrate how to make such a connection manifest, we embed the Peccei-Quinn mechanism into the vector-like model of dynamical supersymmetry breaking a la IYIT. Here, we rely on the anomaly-free discrete Z4R symmetry required in models of pure gravity mediation to solve the mu problem to protect the Peccei-Quinn symmetry from the dangerous effect of higher-dimensional operators. This results in a rich phenomenology featuring a QCD axion with a decay constant of O(10^10) GeV and mixed WIMP/axion dark matter. In addition, exactly five pairs of extra 5 and 5* matter multiplets, directly coupled to the supersymmetry breaking sector and with masses close to the gravitino mass, m3/2 ~ 100 TeV, are needed to cancel the Z4R anomalies.

  20. Dynamical evolution of supernova remnants breaking through molecular clouds

    E-Print Network [OSTI]

    Cho, Wankee; Koo, Bon-Chul

    2015-01-01T23:59:59.000Z

    We carry out three-dimensional hydrodynamic simulations of the supernova remnants (SNRs) produced inside molecular clouds (MCs) near their surface using the HLL code (Harten et al. 1983). We explore the dynamical evolution and the X-ray morphology of SNRs after breaking through the MC surface for ranges of the explosion depths below the surface and the density ratios of the clouds to the intercloud media (ICM). We find that if an SNR breaks out through an MC surface in its Sedov stage, the outermost dense shell of the remnant is divided into several layers. The divided layers are subject to the Rayleigh-Taylor instability and fragmented. On the other hand, if an SNR breaks through an MC after the remnant enters the snowplow phase, the radiative shell is not divided to layers. We also compare the predictions of previous analytic solutions for the expansion of SNRs in stratified media with our onedimensional simulations. Moreover, we produce synthetic X-ray surface brightness in order to research the center-bri...

  1. Modeling suggests that oblique extension facilitates rifting and continental break-up

    E-Print Network [OSTI]

    Kaus, Boris

    Modeling suggests that oblique extension facilitates rifting and continental break-up Sascha Brune; accepted 5 June 2012; published 2 August 2012. [1] In many cases the initial stage of continental break-up was and is associated with oblique rifting. That includes break-up in the Southern and Equatorial Atlantic, separation

  2. GENTLE IONISATION AND VIOLENT BREAK-UP OF MOLECULES USING SOFT X-RAYS

    E-Print Network [OSTI]

    Bapat, Bhas

    GENTLE IONISATION AND VIOLENT BREAK-UP OF MOLECULES USING SOFT X-RAYS Bhas Bapat PRL, Ahmedabad RRCAT Indore, June 2012 BHAS BAPAT (PRL, AHMEDABAD) BREAK-UP OF MOLECULES USING SOFT X-RAYS RRCAT INDORE INVESTIGATED RECENT RESULTS BHAS BAPAT (PRL, AHMEDABAD) BREAK-UP OF MOLECULES USING SOFT X-RAYS RRCAT INDORE

  3. Functional Characterization of Kansl2 and Its Role in Mitochondrial DNA Repair and Maintenance

    E-Print Network [OSTI]

    Liau, Wei-Siang

    2012-01-01T23:59:59.000Z

    understanding of the maintenance and repair of the mtDNA,A is necessary for mtDNA maintenance and embryogenesis in1997). Mitochondrial DNA maintenance in vertebrates. Annu

  4. Plug repairs of marine glass fiber / vinyl ester laminates subjected to uniaxial tension

    E-Print Network [OSTI]

    Michelis, Alexandros

    2009-01-01T23:59:59.000Z

    Glass fiber/vinyl ester composite laminates are currently being used and proposed for the hulls, bulkheads, and superstructures of large ships. This thesis examines the effectiveness of the repair of such laminates using ...

  5. Review of Maintenance and Repair Times for Components in Technological Facilities

    SciTech Connect (OSTI)

    L. C. Cadwallader

    2012-11-01T23:59:59.000Z

    This report is a compilation of some unique component repair time data and it also presents citations of more extensive reports where lists of repair times can be found. This collection of information should support analysts who seek to quantify maintainability and availability of high technology and nuclear energy production systems. While there are newer sources of repair time information, most, if not all, of the newer sources are proprietary and cannot be shared. This report offers data that, while older, is openly accessible and can serve as reasonable estimates of repair times, at least for initial studies. Some times were found for maintenance times in radiation environments, and some guidance for multiplicative factors to use to account for work in contamination areas.

  6. Modeling and centralization of strategic inventory for repairable and long lead-time spare parts

    E-Print Network [OSTI]

    Duncan, Tyeliah Elaine

    2011-01-01T23:59:59.000Z

    This thesis develops an optimal inventory model for repairable and long leadtime spare parts for an Engine overhaul business. In addition, it presents a business case for centralization of inventory. Pratt & Whitney purchased ...

  7. Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    and J. D. Puskas. Mitral-valve repair versus replacement forbioprosthetic heart valves. Ann. Thorac. Surg. 71:S417–mechanics of arti?cial heart valves. Clin. Exp. Pharmacol.

  8. Tiny Terminators: New Micro-Robots Assemble, Repair Themselves and Are Surprisingly Strong

    Broader source: Energy.gov [DOE]

    Tiny robots that can assemble and repair themselves? Watch a video of Argonne National Laboratory's micro-robots that easily perform tasks that can challenge other robots, including moving objects that are larger than themselves.

  9. Consistency Management with Repair Actions Christian Nentwich, Wolfgang Emmerich and Anthony Finkelstein

    E-Print Network [OSTI]

    van der Hoek, André

    Consistency Management with Repair Actions Christian Nentwich, Wolfgang Emmerich and Anthony Finkelstein Department of Computer Science University College London Gower Street, London WC1E 6BT, UK {c.nentwich,w.emmerich

  10. Use of CFRP Overlays to Repair Fatigue Damage in Steel Bridge Girders and Components

    E-Print Network [OSTI]

    Gangel, Regan Elisabeth

    2012-05-31T23:59:59.000Z

    Fatigue damage in steel girder bridges built prior to the mid-1980s is common due to distortion-induced fatigue. Different repair techniques have been developed and implemented to retrofit bridges of this era with existing fatigue damage...

  11. Community-Minded Interns at Savannah River Site Help Area Residents in Need with Home Repairs

    Broader source: Energy.gov [DOE]

    AIKEN, S.C. – More than two dozen college interns who worked at the Savannah River Site (SRS) this summer joined other volunteers and headed into area neighborhoods to help people in need with home repairs.

  12. RESTORING A DAMAGED 16-YEAR -OLD INSULATING POLYMER CONCRETE DIKE OVERLAY: REPAIR MATERIALS AND TECHNOLOGIES.

    SciTech Connect (OSTI)

    SUGAMA,T.

    2007-01-01T23:59:59.000Z

    The objective of this program was to design and formulate organic polymer-based material systems suitable for repairing and restoring the overlay panels of insulating lightweight polymer concrete (ILPC) from the concrete floor and slope wall of a dike at KeySpan liquefied natural gas (LNG) facility in Greenpoint, Brooklyn, NY, just over sixteen years ago. It also included undertaking a small-scale field demonstration to ensure that the commercial repairing technologies were applicable to the designed and formulated materials.

  13. Endovascular Abdominal Aortic Aneurysm Repair in the Presence of a Kidney Transplant: Therapeutic Considerations

    SciTech Connect (OSTI)

    Karkos, Christos D., E-mail: ckarkos@hotmail.com; McMahon, Greg [Leicester Royal Infirmary, Department of Vascular and Endovascular Surgery (United Kingdom); Fishwick, Guy [Leicester Royal Infirmary, Department of Radiology (United Kingdom); Lambert, Kelly; Bagga, Ajay; McCarthy, Mark J. [Leicester Royal Infirmary, Department of Vascular and Endovascular Surgery (United Kingdom)

    2006-04-15T23:59:59.000Z

    Abdominal aortic aneurysm (AAA) repair in the presence of a kidney transplant can be extremely challenging, as it carries significant risks of renal ischemia. Endovascular repair is an attractive option, as it can be performed with little or no impairment of renal arterial flow. We describe the endovascular management of a recurrent AAA in a patient with a functioning renal transplant using a custom-made aorto-uni-iliac device. We discuss the planning and the potential problems of the technique.

  14. Lack of Bystander Effects From High LET Radiation For Early Cytogenetic Endpoints.

    SciTech Connect (OSTI)

    Groesser, Torsten; Cooper, Brian; Rydberg, Bjorn

    2008-05-07T23:59:59.000Z

    The aim of this work was to study radiation-induced bystander effects for early cytogenetic end points in various cell lines using the medium transfer technique after exposure to high- and low-LET radiation. Cells were exposed to 20 MeV/ nucleon nitrogen ions, 968 MeV/nucleon iron ions, or 575 MeV/nucleon iron ions followed by transfer of the conditioned medium from the irradiated cells to unirradiated test cells. The effects studied included DNA double-strand break induction, {gamma}-H2AX focus formation, induction of chromatid breaks in prematurely condensed chromosomes, and micronucleus formation using DNA repair-proficient and -deficient hamster and human cell lines (xrs6, V79, SW48, MO59K and MO59J). Cell survival was also measured in SW48 bystander cells using X rays. Although it was occasionally possible to detect an increase in chromatid break levels using nitrogen ions and to see a higher number of {gamma}-H2AX foci using nitrogen and iron ions in xrs6 bystander cells in single experiments, the results were not reproducible. After we pooled all the data, we could not verify a significant bystander effect for any of these end points. Also, we did not detect a significant bystander effect for DSB induction or micronucleus formation in these cell lines or for clonogenic survival in SW48 cells. The data suggest that DNA damage and cytogenetic changes are not induced in bystander cells. In contrast, data in the literature show pronounced bystander effects in a variety of cell lines, including clonogenic survival in SW48 cells and induction of chromatid breaks and micronuclei in hamster cells. To reconcile these conflicting data, it is possible that the epigenetic status of the specific cell line or the precise culture conditions and medium supplements, such as serum, may be critical for inducing bystander effects.

  15. Leak before break application in French PWR plants under operation

    SciTech Connect (OSTI)

    Faidy, C. [EDF SEPTEN, Villeurbanne (France)

    1997-04-01T23:59:59.000Z

    Practical applications of the leak-before break concept are presently limited in French Pressurized Water Reactors (PWR) compared to Fast Breeder Reactors. Neithertheless, different fracture mechanic demonstrations have been done on different primary, auxiliary and secondary PWR piping systems based on similar requirements that the American NUREG 1061 specifications. The consequences of the success in different demonstrations are still in discussion to be included in the global safety assessment of the plants, such as the consequences on in-service inspections, leak detection systems, support optimization,.... A large research and development program, realized in different co-operative agreements, completes the general approach.

  16. Charge symmetry breaking in n p --> d pi^0

    E-Print Network [OSTI]

    A. K. Opper; E. Korkmaz; D. A. Hutcheon; R. Abegg; C. A. Davis; R. W. Finlay; P. W. Green; L. G. Greeniaus; D. V. Jordan; J. A. Niskanen; G. V. O'Rielly; T. A. Porcelli; S. D. Reitzner; P. L. Walden; S. Yen

    2003-06-19T23:59:59.000Z

    The forward--backward asymmetry in n p --> d pi^0, which must be zero in the center-of-mass system if charge symmetry is respected, has been measured to be [17.2 +/- 8 (stat) +/- 5.5 (sys)] * 10^{-4}, at an incident neutron energy of 279.5 MeV. This charge symmetry breaking observable was extracted by fitting the data with GEANT-based simulations and is compared to recent chiral effective field theory calculations, with implications regarding the value of the u d quark mass difference.

  17. Low-energy Supersymmetry Breaking Without the Gravitino Problem

    E-Print Network [OSTI]

    Hook, Anson

    2015-01-01T23:59:59.000Z

    In models of low-energy gauge mediation, the observed Higgs mass is in tension with the cosmological limit on the gravitino mass $m_{3/2} \\lesssim 16$ eV. We present an alternative mediation mechanism of supersymmetry breaking via a $U(1)$ $D$-term with an $E_6$-inspired particle content, which we call "vector mediation". The gravitino mass can be in the eV range. The sfermion masses are at the 10 TeV scale, while gauginos around a TeV. This mechanism also greatly ameliorates the $\\mu$-problem.

  18. A dynamical symmetry breaking model in Weyl space

    E-Print Network [OSTI]

    A. Feoli; W. R. Wood; G. Papini

    1998-05-11T23:59:59.000Z

    The dynamical process following the breaking of Weyl geometry to Riemannian geometry is considered by studying the motion of de Sitter bubbles in a Weyl vacuum. The bubbles are given in terms of an exact, spherically symmetric thin shell solution to the Einstein equations in a Weyl-Dirac theory with a time-dependent scalar field of the form beta = f(t)/r. The dynamical solutions obtained lead to a number of possible applications. An important feature of the thin shell model is the manner in which beta provides a connection between the interior and exterior geometries since information about the exterior geometry is contained in the boundary conditions for beta.

  19. Symmetry Breaking of H2 Dissociation by a Single Photon

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over Our InstagramStructureProposed Action Title:SustainableDepartmentSymmetry Breaking

  20. System Break-Out Session | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOriginEducationVideoStrategic SafetyGeothermal/Ground-Source HeatSweptCathodeSyntheticBreak-Out

  1. In situ repair of a failed compression fitting

    DOE Patents [OSTI]

    Wolbert, R.R.; Jandrasits, W.G.

    1985-08-05T23:59:59.000Z

    A method and apparatus for the in situ repair of a failed compression fitting is provided. Initially, a portion of a guide tube is inserted coaxially in the bore of the compression fitting and locked therein. A close fit dethreading device is then coaxially mounted on the guide tube to cut the threads from the fitting. Thereafter, the dethreading device and guide tube are removed and a new fitting is inserted onto the dethreaded fitting with the body of the new fitting overlaying the dethreaded portion. Finally, the main body of the new fitting is welded to the main body of the old fitting whereby a new threaded portion of the replacement fitting is precisely coaxial with the old threaded portion. If needed, a bushing is located on the dethreaded portion which is sized to fit snugly between the dethreaded portion and the new fitting. Preferably, the dethreading device includes a cutting tool which is moved incrementally in a radial direction whereby the threads are cut from the threaded portion of the failed fitting in increments.

  2. In situ repair of a failed compression fitting

    DOE Patents [OSTI]

    Wolbert, Ronald R. (McKees Rocks, PA); Jandrasits, Walter G. (Pittsburgh, PA)

    1986-01-01T23:59:59.000Z

    A method and apparatus for the in situ repair of a failed compression fitg is provided. Initially, a portion of a guide tube is inserted coaxially in the bore of the compression fitting and locked therein. A close fit dethreading device is then coaxially mounted on the guide tube to cut the threads from the fitting. Thereafter, the dethreading device and guide tube are removed and a new fitting is inserted onto the dethreaded fitting with the body of the new fitting overlaying the dethreaded portion. Finally, the main body of the new fitting is welded to the main body of the old fitting whereby a new threaded portion of the replacement fitting is precisely coaxial with the old threaded portion. If needed, a bushing is located on the dethreaded portion which is sized to fit snugly between the dethreaded portion and the new fitting. Preferably, the dethreading device includes a cutting tool which is moved incrementally in a radial direction whereby the threads are cut from the threaded portion of the failed fitting in increments.

  3. Remote Welding, NDE and Repair of DOE Standardized Canisters

    SciTech Connect (OSTI)

    Eric Larsen; Art Watkins; Timothy R. McJunkin; Dave Pace; Rodney Bitsoi

    2006-05-01T23:59:59.000Z

    The U.S. Department of Energy (DOE) created the National Spent Nuclear Fuel Program (NSNFP) to manage DOE’s spent nuclear fuel (SNF). One of the NSNFP’s tasks is to prepare spent nuclear fuel for storage, transportation, and disposal at the national repository. As part of this effort, the NSNFP developed a standardized canister for interim storage and transportation of SNF. These canisters will be built and sealed to American Society of Mechanical Engineers (ASME) Section III, Division 3 requirements. Packaging SNF usually is a three-step process: canister loading, closure welding, and closure weld verification. After loading SNF into the canisters, the canisters must be seal welded and the welds verified using a combination of visual, surface eddy current, and ultrasonic inspection or examination techniques. If unacceptable defects in the weld are detected, the defective sections of weld must be removed, re-welded, and re-inspected. Due to the high contamination and/or radiation fields involved with this process, all of these functions must be performed remotely in a hot cell. The prototype apparatus to perform these functions is a floor-mounted carousel that encircles the loaded canister; three stations perform the functions of welding, inspecting, and repairing the seal welds. A welding operator monitors and controls these functions remotely via a workstation located outside the hot cell. The discussion describes the hardware and software that have been developed and the results of testing that has been done to date.

  4. the Adaptive Response, Genetic Haplo-Insufficiency and Genomic Instability

    SciTech Connect (OSTI)

    Geard, Charles R.

    2014-12-12T23:59:59.000Z

    The linear no-threshold (LNT) hypothesis is the driving force in the establishment of radiation protection standards. However, the scientific basis for linearity has been brought into question, particularly due to the concerns about induced radiation resistance as it pertains to oxidative stress. Specifically, we investigated the observation that tumor hypoxia is associated with malignant progression, increased metastases, chemo- and radioresistance and poor prognosis. Experiments were conducted with non-malignant 3T3/NIH cells and normal human lung fibroblasts (NHLF) that were subjected to ?-irradiation under the levels of oxygen resembling those in growing tumors, and related our data to the concentrations of dissolved oxygen (DO), which is a better indicator of the amounts of residual oxygen inside the cells cultured in the hypoxic or anoxic atmosphere. We found that at DO levels about 0.5 mg/L cells subjected to both short-term (17 hours) and prolonged (48-72 hours) hypoxia continued to proliferate, and that apoptotic events were decreased at the early hours of hypoxic treatment. We showed that the short-term hypoxia up-regulated p53-binding protein 1 (53BP1) and resulted in facilitated 53BP1 nuclear foci formation and disappearance, thus indicating the higher efficiency of DNA double strand breaks repair processes. The latter was confirmed by the lower micronuclei incidence in irradiated hypoxic cells.

  5. ExpandplusCrystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

    SciTech Connect (OSTI)

    M Langelier; J Planck; S Roy; J Pascal

    2011-12-31T23:59:59.000Z

    Poly(ADP-ribose) polymerase-1 (PARP-1) has two homologous zinc finger domains, Zn1 and Zn2, that bind to a variety of DNA structures to stimulate poly(ADP-ribose) synthesis activity and to mediate PARP-1 interaction with chromatin. The structural basis for interaction with DNA is unknown, which limits our understanding of PARP-1 regulation and involvement in DNA repair and transcription. Here, we have determined crystal structures for the individual Zn1 and Zn2 domains in complex with a DNA double strand break, providing the first views of PARP-1 zinc fingers bound to DNA. The Zn1-DNA and Zn2-DNA structures establish a novel, bipartite mode of sequence-independent DNA interaction that engages a continuous region of the phosphodiester backbone and the hydrophobic faces of exposed nucleotide bases. Biochemical and cell biological analysis indicate that the Zn1 and Zn2 domains perform distinct functions. The Zn2 domain exhibits high binding affinity to DNA compared with the Zn1 domain. However, the Zn1 domain is essential for DNA-dependent PARP-1 activity in vitro and in vivo, whereas the Zn2 domain is not strictly required. Structural differences between the Zn1-DNA and Zn2-DNA complexes, combined with mutational and structural analysis, indicate that a specialized region of the Zn1 domain is re-configured through the hydrophobic interaction with exposed nucleotide bases to initiate PARP-1 activation.

  6. DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage

    E-Print Network [OSTI]

    Marchetti, Francesco

    2008-01-01T23:59:59.000Z

    male germ cells handle DNA damage? Toxicol. Appl. Pharmacol.strand breaks and DNA base damage at different cellularrelationship to genetic damage, Mutat. Res. 216 (1989) 221-

  7. DNA Repair Decline During Mouse Spermiogenesis Results in the Accumulation of Heritable DNA Damage

    E-Print Network [OSTI]

    Marchetti, Francesco

    2008-01-01T23:59:59.000Z

    male germ cells handle DNA damage? Toxicol. Appl. Pharmacol.strand breaks and DNA base damage at different cellularrelationship to genetic damage, Mutat. Res. 216 (1989) 221-

  8. Pulsar Emission above the Spectral Break - A Stacked Approach

    E-Print Network [OSTI]

    McCann, Andrew

    2015-01-01T23:59:59.000Z

    NASA's Fermi space telescope has provided us with a bountiful new population of gamma-ray sources following its discovery of 150 new gamma-ray pulsars. One common feature exhibited by all of these pulsars is the form of their spectral energy distribution, which can be described by a power law followed by a spectral break occurring between $\\sim$1 and $\\sim$8 GeV. The common wisdom is that the break is followed by an exponential cut-off driven by radiation/reaction-limited curvature emission. The discovery of pulsed gamma rays from the Crab pulsar, the only pulsar so far detected at very high energies (E$>$100GeV), contradicts this "cutoff" picture. Here we present a new stacked analysis with an average of 4.2 years of data on 115 pulsars published in the 2nd LAT catalog of pulsars. This analysis is sensitive to low-level $\\sim$100 GeV emission which cannot be resolved in individual pulsars but can be detected from an ensemble.

  9. The gravitational wave spectrum from cosmological B-L breaking

    SciTech Connect (OSTI)

    Buchmüller, W.; Domcke, V.; Kamada, K. [Deutsches Elektronen-Synchrotron DESY, 22607 Hamburg (Germany); Schmitz, K., E-mail: buchmuwi@mail.desy.de, E-mail: valerie.domcke@desy.de, E-mail: kohei.kamada@desy.de, E-mail: kai.schmitz@ipmu.jp [Kavli IPMU (WPI), University of Tokyo, Kashiwa 277-8583 (Japan)

    2013-10-01T23:59:59.000Z

    Cosmological B-L breaking is a natural and testable mechanism to generate the initial conditions of the hot early universe. If B-L is broken at the grand unification scale, the false vacuum phase drives hybrid inflation, ending in tachyonic preheating. The decays of heavy B-L Higgs bosons and heavy neutrinos generate entropy, baryon asymmetry and dark matter and also control the reheating temperature. The different phases in the transition from inflation to the radiation dominated phase produce a characteristic spectrum of gravitational waves. We calculate the complete gravitational wave spectrum due to inflation, preheating and cosmic strings, which turns out to have several features. The production of gravitational waves from cosmic strings has large uncertainties, with lower and upper bounds provided by Abelian Higgs strings and Nambu-Goto strings, implying ?{sub GW}h{sup 2} ? 10{sup ?13}–10{sup ?8}, much larger than the spectral amplitude predicted by inflation. Forthcoming gravitational wave detectors such as eLISA, advanced LIGO, ET, BBO and DECIGO will reach the sensitivity needed to test the predictions from cosmological B-L breaking.

  10. Bending-induced Symmetry Breaking of Lithiation in Germanium Nanowires

    SciTech Connect (OSTI)

    Gu, Meng; Yang, Hui; Perea, Daniel E.; Zhang, Jiguang; Zhang, Sulin; Wang, Chong M.

    2014-08-01T23:59:59.000Z

    From signal transduction of living cells to oxidation and corrosion of metals, mechanical stress intimately couples with chemical reactions, regulating these biological and physiochemical processes. The coupled effect is particularly evident in electrochemical lithiation/delithiation cycling of high-capacity electrodes, such as silicon (Si), where on one hand lithiation-generated stress mediates lithiation kinetics, and on the other electrochemical reaction rate regulates stress generation and mechanical failure of the electrodes. Here we report for the first time the evidence on the controlled lithiation in germanium nanowires (GeNWs) through external bending. Contrary to the symmetric core-shell lithiation in free-standing GeNWs, we show bending GeNWs breaks the lithiation symmetry, speeding up lithaition at the tensile side while slowing down at the compressive side of the GeNWs. The bending-induced symmetry breaking of lithiation in GeNWs is further corroborated by chemomechanical modeling. In the light of the coupled effect between lithiation kinetics and mechanical stress in the electrochemical cycling, our findings shed light on strain/stress engineering of durable high-rate electrodes and energy harvesting through mechanical motion.

  11. Aerosol cluster impact and break-up : model and implementation.

    SciTech Connect (OSTI)

    Lechman, Jeremy B.

    2010-10-01T23:59:59.000Z

    In this report a model for simulating aerosol cluster impact with rigid walls is presented. The model is based on JKR adhesion theory and is implemented as an enhancement to the granular (DEM) package within the LAMMPS code. The theory behind the model is outlined and preliminary results are shown. Modeling the interactions of small particles is relevant to a number of applications (e.g., soils, powders, colloidal suspensions, etc.). Modeling the behavior of aerosol particles during agglomeration and cluster dynamics upon impact with a wall is of particular interest. In this report we describe preliminary efforts to develop and implement physical models for aerosol particle interactions. Future work will consist of deploying these models to simulate aerosol cluster behavior upon impact with a rigid wall for the purpose of developing relationships for impact speed and probability of stick/bounce/break-up as well as to assess the distribution of cluster sizes if break-up occurs. These relationships will be developed consistent with the need for inputs into system-level codes. Section 2 gives background and details on the physical model as well as implementations issues. Section 3 presents some preliminary results which lead to discussion in Section 4 of future plans.

  12. INTERNAL REPAIR OF GAS PIPLINES SURVEY OF OPERATOR EXPERIENCE AND INDUSTRY NEEDS REPORT

    SciTech Connect (OSTI)

    Ian D. Harris

    2003-09-01T23:59:59.000Z

    A repair method that can be applied from the inside of a gas transmission pipeline (i.e., a trenchless repair) is an attractive alternative to conventional repair methods since the need to excavate the pipeline is precluded. This is particularly true for pipelines in environmentally sensitive and highly populated areas. The objectives of the project are to evaluate, develop, demonstrate, and validate internal repair methods for pipelines; develop a functional specification for an internal pipeline repair system; and prepare a recommended practice for internal repair of pipelines. The purpose of this survey is to better understand the needs and performance requirements of the natural gas transmission industry regarding internal repair. A total of fifty-six surveys were sent to pipeline operators. A total of twenty completed surveys were returned, representing a 36% response rate, which is considered very good given the fact that tailored surveys are known in the marketing industry to seldom attract more than a 10% response rate. The twenty survey responses produced the following principal conclusions: (1) Use of internal weld repair is most attractive for river crossings, under other bodies of water (e.g., lakes and swamps) in difficult soil conditions, under highways, under congested intersections, and under railway crossings. All these areas tend to be very difficult and very costly if, and where, conventional excavated repairs may be currently used. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling (HDD) when a new bore must be created to solve a leak or other problem in a water/river crossing. (3) The typical travel distances required can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). In concept, these groups require pig-based systems; despooled umbilical systems could be considered for the first two groups. For the last group a self-propelled system with an onboard self-contained power and welding system is required. (4) Pipe size range requirements range from 50.8 mm (2 in.) through 1,219.2 mm (48 in.) in diameter. The most common size range for 80% to 90% of operators surveyed is 508 mm to 762 mm (20 in. to 30 in.) diameter, with 95% using 558.8 mm (22 in.) diameter pipe.

  13. Development of bonded composite doublers for the repair of oil recovery equipment.

    SciTech Connect (OSTI)

    Roach, David W.; Rackow, Kirk A.

    2005-06-01T23:59:59.000Z

    An unavoidable by-product of a metallic structure's use is the appearance of crack and corrosion flaws. Economic barriers to the replacement of these structures have created an aging infrastructure and placed even greater demands on efficient and safe repair methods. In the past decade, an advanced composite repair technology has made great strides in commercial aviation use. Extensive testing and analysis, through joint programs between the Sandia Labs FAA Airworthiness Assurance Center and the aviation industry, have proven that composite materials can be used to repair damaged aluminum structure. Successful pilot programs have produced flight performance history to establish the durability of bonded composite patches as a permanent repair on commercial aircraft structures. With this foundation in place, this effort is adapting bonded composite repair technology to civil structures. The use of bonded composite doublers has the potential to correct the difficulties associated with current repair techniques and the ability to be applied where there are no rehabilitation options. It promises to be cost-effective with minimal disruption to the users of the structure. This report concludes a study into the application of composite patches on thick steel structures typically used in mining operations. Extreme fatigue, temperature, erosive, and corrosive environments induce an array of equipment damage. The current weld repair techniques for these structures provide a fatigue life that is inferior to that of the original plate. Subsequent cracking must be revisited on a regular basis. The use of composite doublers, which do not have brittle fracture problems such as those inherent in welds, can help extend the structure's fatigue life and reduce the equipment downtime. Two of the main issues for adapting aircraft composite repairs to civil applications are developing an installation technique for carbon steel and accommodating large repairs on extremely thick structures. This study developed and proved an optimum field installation process using specific mechanical and chemical surface preparation techniques coupled with unique, in-situ heating methods. In addition, a comprehensive performance assessment of composite doubler repairs was completed to establish the viability of this technology for large, steel structures. The factors influencing the durability of composite patches in severe field environments were evaluated along with related laminate design issues.

  14. Relocation and repair of the National Geotechnical Centrifuge. Final report

    SciTech Connect (OSTI)

    Cheney, J.A. [California Univ., Davis, CA (United States). Center for Geotechnical Modeling

    1994-10-01T23:59:59.000Z

    In January of 1984, the large geotechnical centrifuge located at NASA Ames Research Center, was in the first stages of operational checkout when the main thrust bearing of the large D.C. drive motor failed. After many months of investigation and proposals for repair of the facility, it became evident that it would be far more advantageous to the engineering community to remove those components of the centrifuge that were undamaged to the Davis campus and replace the drive system completely. The large centrifuge had cost over 2 million dollars to build, and it would have been irresponsible to simply scrap it. Recognizing this fact, funds were solicited and received from various sources, and Beam Engineering Inc. was contracted to design and construct the centrifuge at its new location. The University of California contributed a quarter of a million dollars and Tyndall Air Force Base, through Los Alamos National Laboratory, contributed $140,000. There were funds also contributed by LANL, LLNL, US Navy and NSF. The first stage in the phased development of the newly located centrifuge is nearing completion, which prompts the writing of this report. By the time that this report reaches the reader the first runs of the centrifuge will have been completed. The present report describes the present capability of the centrifuge and the plans for upgrading as time goes on. Several pilot studies were carried out. The experiments involved (1) the effects of nearby explosions on buried thin walled containers and (2) the advection and dispersion of toxic waste water through soils.

  15. Influence of steam generator plugging and break size on large-break loss-of-collant accidents

    SciTech Connect (OSTI)

    Stritar, A.; Mavko, B. [Jozef Stefan Institute, Ljubljana (El Salvador)

    1991-07-01T23:59:59.000Z

    The large-break loss-of-coolant accident (LBLOCA) is the design-basis accident in the Krsko pressurized-water reactor, the only power reactor in Slovenia. Because numbers of steam generator tubes are plugged as the steam generator ages, and this directly influences the primary system behavior during an LBLOCA, this accident was re-examined assuming various proportions of blocked tube from 0 to 22%. The size of the break was changes from 25 to 45% of the initial cold-leg cross section. The analysis was made with RELAP4/MOD6 as the main code in the conservative mode rather than as the best-estimate code. The methodology separately considers the blowdown phase, the refill phase, and the reflood phase. It was found that the peak clad temperature rises as plugging increases up to about 10% plugging and tends to be constant or even decrease as the plugging increases beyond this point. It was also found that results are strongly dependent on the methodology used. 17 refs., 9 figs., 3 tabs.

  16. SU(3) and Isospin Breaking Effects on B to PPP Amplitudes

    E-Print Network [OSTI]

    He, Xiao-Gang; Xu, Dong

    2014-01-01T23:59:59.000Z

    Several modes of $B$ decays into three pesudoscalar octet mesons PPP have been measured. These decays have provided useful information for B decays in the standard model (SM). Some of powerful tools in analyzing B decays are flavor $SU(3)$ and isospin symmetries. Such analyses are usually hampered by $SU(3)$ breaking effects due to a relatively large strange quark mass which breaks SU(3) symmetry down to isospin symmetry. The isospin symmetry also breaks down when up and down quark mass difference is non-zero. It is therefore interesting to find relations which are not sensitive to $SU(3)$ and isospin breaking effects. We find that the relations among several fully-symmetric $B \\to PPP$ decay amplitudes are immuned from $SU(3)$ breaking effects due a non-zero strange quark mass, and also some of them are not affected by isospin breaking effects. Measurements for these relations can provide important information about B decays in the SM.

  17. Analytical Derivation of Three Dimensional Vorticity Function for wave breaking in Surf Zone

    E-Print Network [OSTI]

    Dutta, R

    2015-01-01T23:59:59.000Z

    In this report, Mathematical model for generalized nonlinear three dimensional wave breaking equations was de- veloped analytically using fully nonlinear extended Boussinesq equations to encompass rotational dynamics in wave breaking zone. The three dimensional equations for vorticity distributions are developed from Reynold based stress equations. Vorticity transport equations are also developed for wave breaking zone. This equations are basic model tools for numerical simulation of surf zone to explain wave breaking phenomena. The model reproduces most of the dynamics in the surf zone. Non linearity for wave height predictions is also shown close to the breaking both in shoaling as well as surf zone. Keyword Wave breaking, Boussinesq equation, shallow water, surf zone. PACS : 47.32-y

  18. ON THE EVOLUTION OF THE SPECTRAL BREAK IN THE AFTERGLOW OF GAMMA-RAY BURSTS

    SciTech Connect (OSTI)

    Dado, Shlomo; Dar, Arnon [Physics Department, Technion, Haifa 32000 (Israel)

    2012-02-20T23:59:59.000Z

    The temporal evolution of the spectral break in the time-resolved spectral energy density of the broadband afterglow of gamma-ray bursts (GRBs) 091127 and 080319B was shown recently to be inconsistent with that expected for the cooling break in the standard fireball model of GRBs. Here we show that it is, however, in good agreement with the predicted temporal evolution of the smooth injection break/bend in the cannonball model of GRBs.

  19. Bubbles Help Break Energy Storage Record for Lithium Air-Batteries

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bubbles Help Break Energy Storage Record for Lithium Air-Batteries Foam-base graphene keeps oxygen flowing in batteries that holds promise for electric vehicles January...

  20. 466, 347 (2010) Intra-unit-cell Electronic C4 Symmetry Breaking

    E-Print Network [OSTI]

    Davis, James C.

    2010-01-01T23:59:59.000Z

    )]( ~ )( ~ )( ~ )( ~ [ 2 1 ][ QQ QQ QQ OyOxCux MMMM +-=)( ~ Q ~M(Qy ) = MCu + MOx - MOy Detecting IUC C4 symmetry breaking

  1. Spontaneous symmetry breaking in a generalized orbital compass model

    E-Print Network [OSTI]

    Lukasz Cincio; Jacek Dziarmaga; Andrzej M. Oles

    2010-09-10T23:59:59.000Z

    We introduce a generalized two-dimensional orbital compass model, which interpolates continuously from the classical Ising model to the orbital compass model with frustrated quantum interactions, and investigate it using the multiscale entanglement renormalization ansatz (MERA). The results demonstrate that increasing frustration of exchange interactions triggers a second order quantum phase transition to a degenerate symmetry broken state which minimizes one of the interactions in the orbital compass model. Using boson expansion within the spin-wave theory we unravel the physical mechanism of the symmetry breaking transition as promoted by weak quantum fluctuations and explain why this transition occurs only surprisingly close to the maximally frustrated interactions of the orbital compass model. The spin waves remain gapful at the critical point, and both the boson expansion and MERA do not find any algebraically decaying spin-spin correlations in the critical ground state.

  2. Spontaneous breaking of spatial symmetries in collective neutrino oscillations

    E-Print Network [OSTI]

    Huaiyu Duan; Shashank Shalgar

    2014-12-22T23:59:59.000Z

    A dense neutrino medium can experience collective oscillations or self-induced flavor transformation through nonlinear neutrino-neutrino refraction. To make the problem of collective neutrino oscillations more tractable, all previous studies on this subject have assumed some spatial symmetry or symmetries in the neutrino medium (e.g., translation symmetries in the early universe and spherical symmetry in core-collapse supernovae). We point out that the collective oscillation modes studied in such models are very special. Using a simple toy model we show that spatial symmetries can be broken spontaneously in collective neutrino oscillations. We also show that the spatial-symmetry-breaking (SSB) modes of neutrino oscillations can exist for both neutrino mass hierarchies and even in the regimes where collective neutrino oscillations were previously thought to be suppressed. This finding calls for study of collective neutrino oscillations in multi-dimensional models.

  3. Spontaneous breaking of spatial symmetries in collective neutrino oscillations

    E-Print Network [OSTI]

    Duan, Huaiyu

    2014-01-01T23:59:59.000Z

    A dense neutrino medium can experience collective oscillations or self-induced flavor transformation through nonlinear neutrino-neutrino refraction. To make the problem of collective neutrino oscillations more tractable, all previous studies on this subject have assumed some spatial symmetry or symmetries in the neutrino medium (e.g., translation symmetries in the early universe and spherical symmetry in core-collapse supernovae). We point out that the collective oscillation modes studied in such models are very special. Using a simple toy model we show that spatial symmetries can be broken spontaneously in collective neutrino oscillations. We also show that the spatial-symmetry-breaking (SSB) modes of neutrino oscillations can exist for both neutrino mass hierarchies and even in the regimes where collective neutrino oscillations were previously thought to be suppressed. This finding calls for study of collective neutrino oscillations in multi-dimensional models.

  4. Radiative PQ Breaking and the Higgs Boson Mass

    E-Print Network [OSTI]

    D'Eramo, Francesco; Pappadopulo, Duccio

    2015-01-01T23:59:59.000Z

    The small and negative value of the Standard Model Higgs quartic coupling at high scales can be understood in terms of anthropic selection on a landscape where large and negative values are favored: most universes have a very short-lived electroweak vacuum and typical observers are in universes close to the corresponding metastability boundary. We provide a simple example of such a landscape with a Peccei-Quinn symmetry breaking scale generated through dimensional transmutation and supersymmetry softly broken at an intermediate scale. Large and negative contributions to the Higgs quartic are typically generated on integrating out the saxion field. Cancellations among these contributions are forced by the anthropic requirement of a sufficiently long-lived electroweak vacuum, determining the multiverse distribution for the Higgs quartic in a similar way to that of the cosmological constant. This leads to a statistical prediction of the Higgs boson mass that, for a wide range of parameters, yields the observed v...

  5. Inertial blob-hole symmetry breaking in magnetised plasma filaments

    E-Print Network [OSTI]

    Kendl, Alexander

    2015-01-01T23:59:59.000Z

    Symmetry breaking between the propagation velocities of magnetised plasma filaments with large positive (blob) and negative (hole) amplitudes, as implied by a dimensional analysis scaling, is studied with global ("full-n") non-Boussinesq gyrofluid computations, which include finite inertia effects through nonlinear polarisation. Interchange blobs on a flat density background have higher inertia and propagate more slowly than holes. In the presence of a large enough density gradient, the effect is reversed: blobs accelerate down the gradient and holes are slowed in their propagation up the gradient. Drift wave blobs spread their initial vorticity rapidly into a fully developed turbulent state, whereas primary holes can remain coherent for many eddy turnover times. The results bear implications for plasma edge zonal flow evolution and tokamak scrape-off-layer transport.

  6. Crucial role of neutrinos in the electroweak symmetry breaking

    SciTech Connect (OSTI)

    Smetana, Adam [Institute of Experimental and Applied Physics, Czech Technical University in Prague, Horská 3a/22, 128 00 Prague 2 (Czech Republic)

    2013-12-30T23:59:59.000Z

    Not only the top-quark condensate appears to be the natural significant source of dynamical electroweak symmetry breaking. Provided the seesaw scenario, the neutrinos can have their Dirac masses large enough so that their condensates contribute significantly to the electroweak scale as well. We address the question of a phenomenological feasibility of the top-quark and neutrino condensation conspiracy against the electroweak symmetry within the simplifying two-composite-Higgs-doublet model. Mandatory is to reproduce the masses of electroweak gauge bosons, the top-quark mass and the recently observed scalar mass of 125 GeV, and to satisfy the upper limits on absolute value of active neutrino masses. To accomplish that, the number of right-handed neutrinos participating on the seesaw mechanism turns out to be rather large, O(100–1000)

  7. Control of coherent backscattering by breaking optical reciprocity

    E-Print Network [OSTI]

    Bromberg, Y; Popoff, S M; Cao, H

    2015-01-01T23:59:59.000Z

    Reciprocity is a universal principle that has a profound impact on many areas of physics. A fundamental phenomenon in condensed-matter physics, optical physics and acoustics, arising from reciprocity, is the constructive interference of quantum or classical waves which propagate along time-reversed paths in disordered media, leading to, for example, weak localization and metal-insulator transition. Previous studies have shown that such coherent effects are suppressed when reciprocity is broken. Here we show that by breaking reciprocity in a controlled manner, we can tune, rather than simply suppress, these phenomena. In particular, we manipulate coherent backscattering of light, also known as weak localization. By utilizing a non-reciprocal magneto-optical effect, we control the interference between time-reversed paths inside a multimode fiber with strong mode mixing, and realize a continuous transition from the well-known peak to a dip in the backscattered intensity. Our results may open new possibilities fo...

  8. Replicating the benefits of closed timelike curves without breaking causality

    E-Print Network [OSTI]

    Xiao Yuan; Syed M. Assad; Jayne Thompson; Jing Yan Haw; Vlatko Vedral; Timothy C. Ralph; Ping Koy Lam; Christian Weedbrook; Mile Gu

    2014-12-17T23:59:59.000Z

    In general relativity, closed timelike curves can break causality with remarkable and unsettling consequences. At the classical level, they induce causal paradoxes disturbing enough to motivate conjectures that explicitly prevent their existence. At the quantum level, resolving such paradoxes induce radical benefits - from cloning unknown quantum states to solving problems intractable to quantum computers. Instinctively, one expects these benefits to vanish if causality is respected. Here we show that in harnessing entanglement, we can efficiently solve NP-complete problems and clone arbitrary quantum states - even when all time-travelling systems are completely isolated from the past. Thus, the many defining benefits of closed timelike curves can still be harnessed, even when causality is preserved. Our results unveil the subtle interplay between entanglement and general relativity, and significantly improve the potential of probing the radical effects that may exist at the interface between relativity and quantum theory.

  9. Single particles accelerate final stages of capillary break up

    E-Print Network [OSTI]

    Lindner, Anke; Wagner, Christian

    2015-01-01T23:59:59.000Z

    Droplet formation of suspensions is present in many industrial and technological processes such as coating and food engineering. Whilst the finite time singularity of the minimum neck diameter in capillary break-up of simple liquids can be described by well known self-similarity solutions, the pinching of non-Brownian suspension depends in a complex way on the particle dynamics in the thinning thread. Here we focus on the very dilute regime where the filament contains only isolated beads to identify the physical mechanisms leading to the pronounced acceleration of the filament thinning observed. This accelerated regime is characterized by an asymmetric shape of the filament with an enhanced curvature that depends on the size and the spatial distribution of the particles within the capillary thread.

  10. Single particles accelerate final stages of capillary break up

    E-Print Network [OSTI]

    Anke Lindner; Jorge Eduardo Fiscina; Christian Wagner

    2015-06-12T23:59:59.000Z

    Droplet formation of suspensions is present in many industrial and technological processes such as coating and food engineering. Whilst the finite time singularity of the minimum neck diameter in capillary break-up of simple liquids can be described by well known self-similarity solutions, the pinching of non-Brownian suspension depends in a complex way on the particle dynamics in the thinning thread. Here we focus on the very dilute regime where the filament contains only isolated beads to identify the physical mechanisms leading to the pronounced acceleration of the filament thinning observed. This accelerated regime is characterized by an asymmetric shape of the filament with an enhanced curvature that depends on the size and the spatial distribution of the particles within the capillary thread.

  11. A Symmetry Breaking Model for X Chromosome Inactivation

    E-Print Network [OSTI]

    M. Nicodemi; A. Prisco

    2008-01-17T23:59:59.000Z

    In mammals, dosage compensation of X linked genes in female cells is achieved by inactivation of one of their two X chromosomes which is randomly chosen. The earliest steps in X-inactivation (XCI), namely the mechanism whereby cells count their X chromosomes and choose between two equivalent X, remain mysterious. Starting from the recent discovery of X chromosome colocalization at the onset of X-inactivation, we propose a Statistical Mechanics model of XCI, which is investigated by computer simulations and checked against experimental data. Our model describes how a `blocking factor' complex is self-assembled and why only one is formed out of many diffusible molecules, resulting in a spontaneous symmetry breaking (SB) in the binding to two identical chromosomes. These results are used to derive a scenario of biological implications describing all current experimental evidences, e.g., the importance of colocalization.

  12. Matter inflation with A{sub 4} flavour symmetry breaking

    SciTech Connect (OSTI)

    Antusch, Stefan [Department of Physics, University of Basel, Klingelbergstrasse 82, Basel, CH-4056 Switzerland (Switzerland); Nolde, David, E-mail: stefan.antusch@unibas.ch, E-mail: david.nolde@unibas.ch [Max-Planck-Institut für Physik (Werner-Heisenberg-Institut), Föhringer Ring 6, München, D-80805 Germany (Germany)

    2013-10-01T23:59:59.000Z

    We discuss model building in tribrid inflation, which is a framework for realising inflation in the matter sector of supersymmetric particle physics models. The inflaton is a D-flat combination of matter fields, and inflation ends by a phase transition in which some Higgs field obtains a vacuum expectation value. We first describe the general procedure for implementing tribrid inflation in realistic models of particle physics that can be applied to a wide variety of BSM particle physics models around the GUT scale. We then demonstrate how the procedure works for an explicit lepton flavour model based on an A{sub 4} family symmetry. The model is both predictive and phenomenologically viable, and illustrates how tribrid inflation connects cosmological and particle physics parameters. In particular, it predicts a relation between the neutrino Yukawa coupling and the running of the spectral index ?{sub s}. We also show how topological defects from the flavour symmetry breaking can be avoided automatically.

  13. Effects of Rotational Symmetry Breaking in Polymer-coated Nanopores

    E-Print Network [OSTI]

    Osmanovic, D; Eccleston, R C; Hoogenboom, B W; Ford, I J

    2015-01-01T23:59:59.000Z

    The statistical theory of polymers tethered around the inner surface of a cylindrical channel has traditionally employed the assumption that the equilibrium density of the polymers is independent of the azimuthal coordinate. However, simulations have shown that this rotational symmetry can be broken when there are attractive interactions between the polymers. We investigate the phases that emerge in these circumstances, and we quantify the effect of the symmetry assumption on the phase behavior of the system. In the absence of this assumption, one can observe large differences in the equilibrium densities between the rotationally symmetric case and the non-rotationally symmetric case. A simple analytical model is developed that illustrates the driving thermodynamic forces responsible for this symmetry breaking. Our results have implications for the current understanding of the polymer behavior in cylindrical nanopores.

  14. HANFORD SITE LOW EXPOSURE PIPELINE REPAIR USING A NON-METALLIC COMPOSITE SYSTEM

    SciTech Connect (OSTI)

    HUTH RJ

    2009-11-12T23:59:59.000Z

    At the Department of Energy, Richland Operations (DOE-RL) Hanford site in eastern Washington, a 350 mm (14 inch) diameter high density polyethylene (HDPE) pump recirculation pipeline failed at a bonded joint adjacent to a radiologically and chemically contaminated groundwater storage basin. The responsible DOE-RL contractor, CH2MHill Plateau Remediation Company, applied a fiberglass reinforced plastic (composite) field repair system to the failed joint. The system was devised specifically for the HDPE pipe repair at the Hanford site, and had not been used on this type of plastic piping previously. This paper introduces the pipe failure scenario, describes the options considered for repair and discusses the ultimate resolution of the problem. The failed pipeline was successfully returned to service with minimal impact on waste water treatment plant operating capacity. Additionally, radiological and chemical exposures to facility personnel were maintained as low as reasonably achievable (ALARA). The repair is considered a success for the near term, and future monitoring will prove whether the repair can be considered for long term service and as a viable alternative for similar piping failures at the Hanford site.

  15. Cosmological moduli problem, supersymmetry breaking, and stability in postinflationary cosmology

    SciTech Connect (OSTI)

    Banks, T.; Berkooz, M. [Department of Physics and Astronomy, Rutgers University, Piscataway, New Jersey 08855-0849 (United States)] [Department of Physics and Astronomy, Rutgers University, Piscataway, New Jersey 08855-0849 (United States); Steinhardt, P.J. [Department of Physics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)] [Department of Physics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)

    1995-07-15T23:59:59.000Z

    We review scenarios that have been proposed to solve the cosmological problem caused by moduli in string theory, the postmodern Polonyi problem (PPP). In particular, we discuss the difficulties encountered by the apparently ``trivial`` solution of this problem, in which moduli masses are assumed to arise from nonperturbative, SUSY-preserving, dynamics at a scale higher than that of SUSY breaking. This suggests a powerful {ital cosmological} {ital vacuum} {ital selection} {ital principle} in superstring theory. However, we argue that if one eschews the possibility of cancellations between different exponentials of the inverse string coupling, the mechanism described above cannot stabilize the dilaton. Thus, even if supersymmetric dynamics gives mass to the other moduli in string theory, the dilaton mass must be generated by SUSY breaking, and dilaton domination of the energy density of the Universe cannot be avoided. We conclude that the only proposal for solving the PPP that works is the intermediate scale inflation scenario of Randall and Thomas. However, we point out that all extant models have ignored unavoidably large inhomogeneities in the cosmological moduli density at very early times, and speculate that the effects associated with nonlinear gravitational collapse of these inhomogeneities may serve as an efficient mechanism for converting moduli into ordinary matter. As an important by-product of this investigation we show that in a postinflationary universe minima of the effective potential with a negative cosmological constant are not stationary points of the classical equations of scalar field cosmology. Instead, such points lead to catastrophic gravitational collapse of that part of the Universe which is attracted to them. Thus postinflationary cosmology dynamically chooses non-negative values of the cosmological constant. This implies that supersymmetry {ital must} be broken in any sensible inflationary cosmology. (Abstract Truncated)

  16. A survey of repair practices for nuclear power plant containment metallic pressure boundaries

    SciTech Connect (OSTI)

    Oland, C.B.; Naus, D.J. [Oak Ridge National Lab., TN (United States)

    1998-05-01T23:59:59.000Z

    The Nuclear Regulatory Commission has initiated a program at the Oak Ridge National Laboratory to provide assistance in their assessment of the effects of potential degradation on the structural integrity and leaktightness of metal containment vessels and steel liners of concrete containments in nuclear power plants. One of the program objectives is to identify repair practices for restoring metallic containment pressure boundary components that have been damaged or degraded in service. This report presents issues associated with inservice condition assessments and continued service evaluations and identifies the rules and requirements for the repair and replacement of nonconforming containment pressure boundary components by welding or metal removal. Discussion topics include base and welding materials, welding procedure and performance qualifications, inspection techniques, testing methods, acceptance criteria, and documentation requirements necessary for making acceptable repairs and replacements so that the plant can be returned to a safe operating condition.

  17. Evaluation of bisphenol E cyanate ester for the resin-injection repair of advanced composites

    SciTech Connect (OSTI)

    Wilber Yaote Lio

    2009-12-19T23:59:59.000Z

    This thesis is a compilation of a general introduction and literature review that ties together the subsequent chapters which consist of two journal articles that have yet to be submitted for publication. The overall topic relates to the evaluation and application of a new class of cyanate ester resin with unique properties that lend it applicable to use as a resin for injection repair of high glass transition temperature polymer matrix composites. The first article (Chapter 2) details the evaluation and optimization of adhesive properties of this cyanate ester and alumina nanocomposites under different conditions. The second article (Chapter 3) describes the development and evaluation of an injection repair system for repairing delaminations in polymer matrix composites.

  18. Automatic coke oven heating control system at Burns Harbor for normal and repair operation

    SciTech Connect (OSTI)

    Battle, E.T.; Chen, K.L. [Bethlehem Steel Corp., Burns Harbor, IN (United States); [Bethlehem Steel Corp., PA (United States)

    1997-12-31T23:59:59.000Z

    An automatic heating control system for coke oven batteries was developed in 1985 for the Burns Harbor No. 1 battery and reported in the 1989 Ironmaking Conference Proceedings. The original system was designed to maintain a target coke temperature at a given production level under normal operating conditions. Since 1989, enhancements have been made to this control system so that it can also control the battery heating when the battery is under repair. The new control system has improved heating control capability because it adjusts the heat input to the battery in response to anticipated changes in the production schedule. During a recent repair of this 82 oven battery, the pushing schedule changed from 102 ovens/day to 88 ovens/day, then back to 102 ovens/day, then to 107 ovens/day. During this repair, the control system was able to maintain the coke temperature average standard deviation at 44 F, with a maximum 75 F.

  19. Hurricane-damaged Gulf of Mexico pipeline repaired with cold forging

    SciTech Connect (OSTI)

    Lewis, G. (Texaco Pipeline Inc., Houma, LA (United States)); DeGruy, P. (Texaco Inc., New Orleans, LA (United States)); Avery, L. (Big Inch Marine Systems Inc., Lafayette, LA (United States))

    1993-05-03T23:59:59.000Z

    Damage to Texaco Pipeline Inc.'s Eugene Island Pipeline System (EIPS) in last year's Hurricane Andrew prompted a complex repair project unique for the Gulf of Mexico. Damage, suffered when the anchor of a runaway semisubmersible drilling rig crashed into the 20-in. EPIS during the height of the storm, caused the pipeline to fail under pressure within 48 hr. after start-up following the storm. The paper describes the importance of the EIPS; system safety; Andrew's damage; locating the leak; repair options; the chosen system; mechanical bonding; end connectors and ball flanges; and diving operations.

  20. Bosh repairs No. 3 blast furnace, Edgar Thomson Plant Mon Valley Works

    SciTech Connect (OSTI)

    Stoupis, M.G.

    1993-01-01T23:59:59.000Z

    The paper describes in detail the steps taken from quenching to dry out of the furnace to repair the bosh area of the No.3 blast furnace. Inspection of the area revealed that there was no brick anywhere in the bosh. Brick in the tuyere breast area had been peeled back to reveal the steel plate, and descaling revealed 14 pipes fully exposed. None were leaking, but one seemed badly deteriorated. Conventional repairs could not take place before the scheduled blow-in. Installation of coolers were instead tried.

  1. Remote reactor repair: GTA (gas tungsten Arc) weld cracking caused by entrapped helium

    SciTech Connect (OSTI)

    Kanne, W.R. Jr.

    1988-01-01T23:59:59.000Z

    A repair patch was welded to the wall of a nuclear reactor tank using remotely controlled thirty-foot long robot arms. Further repair was halted when gas tungsten arc (GTA) welds joining type 304L stainless steel patches to the 304 stainless steel wall developed toe cracks in the heat-affected zone (HAZ). The role of helium in cracking was investigated using material with entrapped helium from tritium decay. As a result of this investigation, and of an extensive array of diagnostic tests performed on reactor tank wall material, helium embrittlement was shown to be the cause of the toe cracks.

  2. Hydrogen bond breaking probed with multidimensional stimulated vibrational echo correlation spectroscopy

    E-Print Network [OSTI]

    Fayer, Michael D.

    Hydrogen bond breaking probed with multidimensional stimulated vibrational echo correlation September 2003 Hydrogen bond population dynamics are extricated with exceptional detail using ultrafast ( 50 of methanol­OD oligomers in CCl4 . Hydrogen bond breaking makes it possible to acquire data for times much

  3. Symmetry Breaking in Graphene Gregory S. Boebinger, National High Magnetic Field Laboratory

    E-Print Network [OSTI]

    Weston, Ken

    Symmetry Breaking in Graphene Gregory S. Boebinger, National High Magnetic Field Laboratory DMR. In this experiment, Landau levels in graphene were used to study the breaking of SU(4) symmetry--a higher dimensional states by their spin polarization. It was found that graphene turns into either a spin ferromagnet

  4. On the Modeling and Simulation of Non-Hydrostatic Dam Break Flows

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    by the failure of the dam structure. The determination of the potential consequences of a dam break requiresOn the Modeling and Simulation of Non-Hydrostatic Dam Break Flows Alexandre Caboussat S´ebastien Boyaval Alexandre Masserey January 1, 2013 Abstract The numerical simulation of three-dimensional dam

  5. Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities

    SciTech Connect (OSTI)

    Denholm, P.; Margolis, R. M.; Ong, S.; Roberts, B.

    2009-12-01T23:59:59.000Z

    Grid parity--or break-even cost--for photovoltaic (PV) technology is defined as the point where the cost of PV-generated electricity equals the cost of electricity purchased from the grid. Break-even cost is expressed in $/W of an installed system. Achieving break-even cost is a function of many variables. Consequently, break-even costs vary by location and time for a country, such as the United States, with a diverse set of resources, electricity prices, and other variables. In this report, we analyze PV break-even costs for U.S. residential customers. We evaluate some key drivers of grid parity both regionally and over time. We also examine the impact of moving from flat to time-of-use (TOU) rates, and we evaluate individual components of the break-even cost, including effect of rate structure and various incentives. Finally, we examine how PV markets might evolve on a regional basis considering the sensitivity of the break-even cost to four major drivers: technical performance, financing parameters, electricity prices and rates, and policies. We find that local incentives rather than ?technical? parameters are in general the key drivers of the break-even cost of PV. Additionally, this analysis provides insight about the potential viability of PV markets.

  6. A model for the ultrasonic detection of surface-breaking cracks by the Scanning

    E-Print Network [OSTI]

    Huerta, Antonio

    A model for the ultrasonic detection of surface-breaking cracks by the Scanning Laser Source, Northwestern University, Evanston, IL 60208, USA Abstract A model for the Scanning Laser Source (SLS) technique- breaking cracks. The generated ultrasonic signal is monitored as a line-focused laser is scanned over

  7. Dam breaking by wave-induced erosional incision N. J. Balmforth,1

    E-Print Network [OSTI]

    Balmforth, Neil

    Dam breaking by wave-induced erosional incision N. J. Balmforth,1 J. von Hardenberg,2 A. Provenzale displacement wave can lead to catastrophic erosional incision of a moraine damming a glacial lake that a single wave is generally unable to break the dam, but a sufficiently large disturbance in an almost

  8. Mitral Web -A New Concept for Mitral Valve Repair: Improved Engineering Design and In-Vitro Studies

    E-Print Network [OSTI]

    Pekkan, Kerem

    Mitral Web - A New Concept for Mitral Valve Repair: Improved Engineering Design and In of Biomedical Engineering, Georgia Institute of Technology, GA, USA Myxomatous mitral valve disease is currently reported that mitral valve repair is preferable to valve replace- ment, as it offers certain advantages

  9. Restoration and repair of 30-year old cooling towers at the Paducah Gaseous Diffusion Plant, Phase I. Draft 1

    SciTech Connect (OSTI)

    Shelton, M.F.

    1985-01-01T23:59:59.000Z

    Early in 1980, a comprehensive reliability study was made to ascertain the ability of the present 30-year old recirculating water system to meet the anticipated load demand through the year 2000. The findings and recommendations of this study were used as a guide to schedule uprating and repairs. This paper deals with the underground distribution system and cooling tower repairs.

  10. The Role of Nucleotide Excision Repair in Restoring Replication Following UV-Induced Damage in Escherichia coli

    E-Print Network [OSTI]

    Courcelle, Justin

    The Role of Nucleotide Excision Repair in Restoring Replication Following UV-Induced Damage DNA synthesis in the absence of nucleotide excision repair does not promote cell survivalA mutants....................... 26 Following low doses of UV irradiation cells lacking nucleotide excision

  11. Hot repair of ceramic burner on hot blast stoves at USS/Kobe`s {number_sign}3 blast furnace

    SciTech Connect (OSTI)

    Bernarding, T.F.; Chemorov, M.; Shimono, S.; Phillips, G.R.

    1997-12-31T23:59:59.000Z

    During the 1992 reline of the No. 3 blast furnace, three new stoves were constructed. The design of the stoves, equipped with internal ceramic burners, was for providing a hot blast temperature of 2,000 F at a wind rate of 140,000 SCFM. After 3 years the performance had deteriorated so the burners were cleaned. When a second cleaning did not improve the performance of No. 3 blast furnace, it was decided to repair the refractory while still hot. The paper describes the hot repair procedures, taking a stove off for repairs, maintenance heat up during repairs, two stove operation, stove commissioning, repair of a ceramic burner, and wet gas prevention.

  12. Breaking FIR-Radio Correlation: The Case of Interacting Galaxies

    E-Print Network [OSTI]

    Donevski, Darko

    2015-01-01T23:59:59.000Z

    Far-infrared (FIR)--radio correlation is a well-established empirical connection between continuum radio and dust emission of star-forming galaxies, used as a tool in determining star-formation rates. Here we point out that in the case of interacting star-forming galaxies this tool might break. Galactic interactions and mergers have been known to give rise to tidal shocks and disrupt morphologies especially in the smaller of the interacting components. Moreover, these shocks can also heat the gas and dust and accelerate particles leading to tidal cosmic-ray population in addition to standard galactic cosmic rays. Both heating and additional non-thermal radiation will obviously affect the FIR-radio correlation of these systems. To test this hypothesis we have analyzed a sample of 43 infrared bright star-forming interacting galaxies at different merger stages. We have found that their FIR-radio correlation parameter and radio emission spectral index vary over different merger stages and behave as it would be ex...

  13. Break-even Costs for Cow/Calf Producers

    E-Print Network [OSTI]

    Sprott, L. R.

    1998-10-14T23:59:59.000Z

    $400 90/600 540 $0.19 $0.37 $0.56 $0.74 90/500 450 $0.22 $0.44 $0.66 $0.89 90/400 360 $0.28 $0.56 $0.83 $1.11 90/300 270 $0.37 $0.74 $1.11 $1.48 80/600 480 $0.21 $0.42 $0.63 $0.83 80/500 400 $0.25 $0.50 $0.75 $1.00 80/400 320 $0.31 $0.63 $0.94 $1.25 80.../300 240 $0.42 $0.83 $1.25 $1.67 70/600 420 $0.24 $0.48 $0.71 $0.95 70/500 350 $0.29 $0.57 $0.86 $1.14 70/400 280 $0.36 $0.71 $1.07 $1.43 70/300 210 $0.48 $0.95 $1.43 $1.90 Table 1 shows break-even costs for 12 production scenarios and four annual cash...

  14. Lyman-break galaxies are they young spheroids?

    E-Print Network [OSTI]

    Matteucci, F

    2002-01-01T23:59:59.000Z

    We have compared the results from a model for the chemical evolution of an elliptical galaxy with initial luminous mass of 2x10^10 M_sun and effective radius of 2 kpc with the recent abundance determinations for the Lyman-break galaxy MS 1512-cB58 at a redshift z=2.7276. After correcting the iron abundance determination for the presence of dust we concluded that the observed [Si/Fe], [Mg/Fe], [N/Fe] are consistent with our model when a galactic age between 20 and 35 Myr is assumed. Moreover, the [N/O] ratio also suggests the same age. This age is in very good agreement with other independent studies based on the analysis of the spectral energy distribution suggesting that this object is younger than 35 Myr. Therefore, we suggest that MS 1512-cB58 is a truly young normal elliptical galaxy experiencing its main episode of star formation and galactic wind.

  15. Breaking the Curse of Cardinality on Bitmap Indexes

    SciTech Connect (OSTI)

    Wu, Kesheng; Wu, Kesheng; Stockinger, Kurt; Shoshani, Arie

    2008-04-04T23:59:59.000Z

    Bitmap indexes are known to be efficient for ad-hoc range queries that are common in data warehousing and scientific applications. However, they suffer from the curse of cardinality, that is, their efficiency deteriorates as attribute cardinalities increase. A number of strategies have been proposed, but none of them addresses the problem adequately. In this paper, we propose a novel binned bitmap index that greatly reduces the cost to answer queries, and therefore breaks the curse of cardinality. The key idea is to augment the binned index with an Order-preserving Bin-based Clustering (OrBiC) structure. This data structure significantly reduces the I/O operations needed to resolve records that cannot be resolved with the bitmaps. To further improve the proposed index structure, we also present a strategy to create single-valued bins for frequent values. This strategy reduces index sizes and improves query processing speed. Overall, the binned indexes with OrBiC great improves the query processing speed, and are 3 - 25 times faster than the best available indexes for high-cardinality data.

  16. Physical Naturalness and Dynamical Breaking of Classical Scale Invariance

    E-Print Network [OSTI]

    Matti Heikinheimo; Antonio Racioppi; Martti Raidal; Christian Spethmann; Kimmo Tuominen

    2014-05-05T23:59:59.000Z

    We propose a model of a confining dark sector, dark technicolor, that communicates with the Standard Model through the Higgs portal. In this model electroweak symmetry breaking and dark matter share a common origin, and the electroweak scale is generated dynamically. Our motivation to suggest this model is the absense of evidence for new physics from recent LHC data. Although the conclusion is far from certain at this point, this lack of evidence may suggest that no mechanism exists at the electroweak scale to stabilise the Higgs mass against radiative corrections from UV physics. The usual reaction to this puzzling situation is to conclude that the stabilising new physics is either hidden from us by accident, or that it appears at energies that are currently inaccessible, such that nature is indeed fine-tuned. In order to re-examine the arguments that have lead to this dichotomy, we review the concept of naturalness in effective field theories, discussing in particular the role of quadratic divergences in relation to different energy scales. This leads us to suggest classical scale invariance as a guidline for model building, implying that explicit mass scales are absent in the underlying theory.

  17. Non-equilibrium evolution of a "Tsunami" Dynamical Symmetry Breaking

    E-Print Network [OSTI]

    Boyanovsky, D; Holman, R; Kumar, S P; Pisarski, R D; Boyanovsky, Daniel; Vega, Hector J. de; Holman, Richard; Pisarski, Robert D.

    1998-01-01T23:59:59.000Z

    We propose to study the non-equilibrium features of heavy-ion collisions by following the evolution of an initial state with a large number of quanta with a distribution around a momentum |\\vec k_0| corresponding to a thin spherical shell in momentum space, a `tsunami'. An O(N); ({\\vec \\Phi}^2)^2 model field theory in the large N limit is used as a framework to study the non-perturbative aspects of the non-equilibrium dynamics including a resummation of the effects of the medium (the initial particle distribution). In a theory where the symmetry is spontaneously broken in the absence of the medium, when the initial number of particles per correlation volume is chosen to be larger than a critical value the medium effects can restore the symmetry of the initial state. We show that if one begins with such a symmetry-restored, non-thermal, initial state, non-perturbative effects automatically induce spinodal instabilities leading to a dynamical breaking of the symmetry. As a result there is explosive particle pro...

  18. Non-equilibrium evolution of a `Tsunami': Dynamical Symmetry Breaking

    E-Print Network [OSTI]

    Daniel Boyanovsky; Hector J. de Vega; Richard Holman; S. Prem Kumar; Robert D. Pisarski

    1997-11-06T23:59:59.000Z

    We propose to study the non-equilibrium features of heavy-ion collisions by following the evolution of an initial state with a large number of quanta with a distribution around a momentum |\\vec k_0| corresponding to a thin spherical shell in momentum space, a `tsunami'. An O(N); ({\\vec \\Phi}^2)^2 model field theory in the large N limit is used as a framework to study the non-perturbative aspects of the non-equilibrium dynamics including a resummation of the effects of the medium (the initial particle distribution). In a theory where the symmetry is spontaneously broken in the absence of the medium, when the initial number of particles per correlation volume is chosen to be larger than a critical value the medium effects can restore the symmetry of the initial state. We show that if one begins with such a symmetry-restored, non-thermal, initial state, non-perturbative effects automatically induce spinodal instabilities leading to a dynamical breaking of the symmetry. As a result there is explosive particle production and a redistribution of the particles towards low momentum due to the nonlinearity of the dynamics. The asymptotic behavior displays the onset of Bose condensation of pions and the equation of state at long times is that of an ultrarelativistic gas although the momentum distribution is non-thermal.

  19. Scales of Fermion Mass Generation and Electroweak Symmetry Breaking

    E-Print Network [OSTI]

    Duane A. Dicus; Hong-Jian He

    2005-06-11T23:59:59.000Z

    The scale of mass generation for fermions (including neutrinos) and the scale for electroweak symmetry breaking (EWSB) can be bounded from above by the unitarity of scattering involving longitudinal weak gauge bosons or their corresponding would-be Goldstone bosons. Including the exact n-body phase space we analyze the 2 --> n ($n \\geq 2$) processes for the fermion-(anti)fermion scattering into multiple gauge boson final states. Contrary to naive energy power counting, we demonstrate that as $n$ becomes large, the competition between an increasing energy factor and a phase-space suppression leads to a {\\it strong new upper bound} on the scale of fermion mass generation at a finite value $n=n_s$, which is {\\it independent of the EWSB scale,} $v = (\\sqrt{2}G_F)^{-1/2}$. For quarks, leptons and Majorana neutrinos, the strongest 2 --> n limits range from about 3TeV to 130-170TeV (with $2\\lesssim n_s \\lesssim 24$), depending on the measured fermion masses. Strikingly, given the tiny neutrino masses as constrained by the neutrino oscillations, neutrinoless double-beta decays and astrophysical observations, the unitarity violation of $\

  20. Symmetry Breaking and Topological Defect Formation in Ion Coulomb Crystals

    E-Print Network [OSTI]

    Pyka, Karsten; Partner, Heather L; Nigmatullin, Ramil; Burgermeister, Tobias; Meier, David-M; Kuhlmann, Kristijan; Retzker, Alex; Plenio, Martin B; Zurek, Wojciech H; del Campo, Adolfo; Mehlstäubler, Tanja E

    2013-01-01T23:59:59.000Z

    Symmetry breaking phase transitions play an important role in nature. When a system traverses such a transition at a finite rate, its causally disconnected regions choose the new broken symmetry state independently. Where such local choices are incompatible, defects will form with densities predicted to follow a power law scaling in the rate of the transition. The importance of this Kibble-Zurek mechanism (KZM) ranges from cosmology to condensed matter [1-4]. In previous tests in homogeneous systems, defect formation was seen, but weak dependence on the transition rate and limited control of external parameters so far prevented tests of KZM scaling. As recently predicted [5-9], in inhomogeneous systems propagation of the critical front enhances the role of causality and steepens scaling of defect density with the transition rate. We use ion Coulomb crystals in a harmonic trap to demonstrate, for the first time, scaling of the number of topological defects with the transition rate - the central prediction of K...

  1. Symmetry Breaking, Unification, and Theories Beyond the Standard Model

    SciTech Connect (OSTI)

    Nomura, Yasunori

    2009-07-31T23:59:59.000Z

    A model was constructed in which the supersymmetric fine-tuning problem is solved without extending the Higgs sector at the weak scale. We have demonstrated that the model can avoid all the phenomenological constraints, while avoiding excessive fine-tuning. We have also studied implications of the model on dark matter physics and collider physics. I have proposed in an extremely simple construction for models of gauge mediation. We found that the {mu} problem can be simply and elegantly solved in a class of models where the Higgs fields couple directly to the supersymmetry breaking sector. We proposed a new way of addressing the flavor problem of supersymmetric theories. We have proposed a new framework of constructing theories of grand unification. We constructed a simple and elegant model of dark matter which explains excess flux of electrons/positrons. We constructed a model of dark energy in which evolving quintessence-type dark energy is naturally obtained. We studied if we can find evidence of the multiverse.

  2. Noncommutative gauge theory and symmetry breaking in matrix models

    SciTech Connect (OSTI)

    Grosse, Harald; Steinacker, Harold [Department of Physics, University of Vienna, Boltzmanngasse5, A-1090 Vienna (Austria); Lizzi, Fedele [Dipartimento di Scienze Fisiche, Universita di Napoli Federico II and INFN, Sezione di Napoli, Via Cintia, 80126 Napoli (Italy); High Energy Physics Group, Departament d'Estructura i Constituents de la Materia and Institut de Ciencies del Cosmos Universitat de Barcelona Barcelona, Catalonia (Spain)

    2010-04-15T23:59:59.000Z

    We show how the fields and particles of the standard model can be naturally realized in noncommutative gauge theory. Starting with a Yang-Mills matrix model in more than four dimensions, an SU(n) gauge theory on a Moyal-Weyl space arises with all matter and fields in the adjoint of the gauge group. We show how this gauge symmetry can be broken spontaneously down to SU(3){sub c}xSU(2){sub L}xU(1){sub Q}[resp. SU(3){sub c}xU(1){sub Q}], which couples appropriately to all fields in the standard model. An additional U(1){sub B} gauge group arises which is anomalous at low energies, while the trace-U(1) sector is understood in terms of emergent gravity. A number of additional fields arise, which we assume to be massive, in a pattern that is reminiscent of supersymmetry. The symmetry breaking might arise via spontaneously generated fuzzy spheres, in which case the mechanism is similar to brane constructions in string theory.

  3. Treatment methods for breaking certain oil and water emulsions

    DOE Patents [OSTI]

    Sealock, Jr., L. John (W. Richland, WA); Baker, Eddie G. (Richland, WA); Elliott, Douglas C. (Richland, WA)

    1992-01-01T23:59:59.000Z

    Disclosed are treatment methods for breaking emulsions of petroleum oil and salt water, fatty oil and water, and those resulting from liquefication of organic material. The emulsions are broken by heating to a predetermined temperature at or above about 200.degree. C. and pressurizing to a predetermined pressure above the vapor pressure of water at the predetermined temperature to produce a heated and pressurized fluid. The heated and pressurized fluid is contained in a single vessel at the predetermined temperature and pressure for a predetermined period of time to effectively separate the emulsion into substantially distinct first and second phases, the first phase comprising primarily the petroleum oil, the second phase comprising primarily the water. The first and second phases are separately withdrawn from the vessel at a withdraw temperature between about 200.degree. C. and 374.degree. C. and a withdraw pressure above the vapor pressure of water at the withdraw temperature. Where solids are present in the certain emulsions, the above described treatment may also effectively separate the certain emulsion into a substantially distinct third phase comprising primarily the solids.

  4. Dietary fish oil and butyrate increase apoptosis and decrease aberrant crypt foci in colon cancer by enhancing histone acetylation and p21waf1/cip1 expression

    E-Print Network [OSTI]

    Covert, Kristy Lynn

    2006-08-16T23:59:59.000Z

    shrinkage, mitochondrial membrane blebbing, nuclear degradation, and DNA fragmentation (Shanmugathasan and Jothy, 2000). As the DNA fragments, the remaining double-strand breaks can be identified by gel electrophoresis, producing a specific pattern..., the nuclear chromatin condenses and DNA is degraded. Cellular remnants are packaged into apoptotic bodies, which are then phagocytized or sloughed into the passing lumenal contents (Vaux and Strasser, 1996). p21Waf1/Cip1 One of the earliest events...

  5. Toward a State of Good Repair for Railroad Bridges through Structural Health Monitoring

    E-Print Network [OSTI]

    Bustamante, Fabián E.

    Toward a State of Good Repair for Railroad Bridges through Structural Health Monitoring NUTC of this research is to add a new tool to the asset management toolbox: structural health monitoring, particularly is Structural Health Monitoring (SHM)? SHM is process of intelligently collecting data from sensors on critical

  6. Multilayer sulfur-resistant composite metal membranes and methods of making and repairing the same

    DOE Patents [OSTI]

    Way, J. Douglas; Hatlevik, Oyvind

    2014-07-15T23:59:59.000Z

    The invention relates to thin, hydrogen-permeable, sulfur-resistant membranes formed from multi-layers of palladium or palladium-alloy coatings on porous, ceramic or metal supports, methods of making these membranes, methods of repairing layers of these membranes and devices that incorporate these membranes.

  7. Development/Plasticity/Repair Deletion of ERK2 Mitogen-Activated Protein Kinase

    E-Print Network [OSTI]

    Development/Plasticity/Repair Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key University, Piscataway, New Jersey 08855-8082 The mitogen-activated protein (MAP) kinases ERK1 and ERK2-specific functions in vivo. We have examined the role of ERK2 in neural development by conditional inactivation

  8. Development/Plasticity/Repair The ERK2 Mitogen-Activated Protein Kinase Regulates the

    E-Print Network [OSTI]

    Development/Plasticity/Repair The ERK2 Mitogen-Activated Protein Kinase Regulates the Timing Oligodendrocytedevelopmentistightlycontrolledbyavarietyofextracellulargrowthanddifferentiationfactors.Themitogen-activated protein kinases (MAPKs), ERK1 and ERK2, are critical intracellular signaling (ERKs) are ubiquitously expressed, coordinately regulated, and highly similar, but Erk2 deletion in mice

  9. Development/Plasticity/Repair Phosphatidylinositol 3-Kinase Activates ERK in Primary

    E-Print Network [OSTI]

    Clapham, David E.

    Development/Plasticity/Repair Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory activation to inflammatory pain. We further investigated the correlationbetweenthePI3KandtheERK294002 and wortmannin, indicative of the activation of PI3K by both agents. ERK activation by capsaicin

  10. Development/Plasticity/Repair Disrupted ERK Signaling during Cortical Development Leads

    E-Print Network [OSTI]

    Development/Plasticity/Repair Disrupted ERK Signaling during Cortical Development Leads to Abnormal disorders arising from copy number variations in the ERK (extracellular signal-regulated kinase) MAP that these changes are due to ERK-dependent dysregulation of cyclin D1 and p27Kip1 , resulting in cell cycle

  11. Lazy Means Smart: Reducing Repair Bandwidth Costs in Erasure-coded Distributed Storage

    E-Print Network [OSTI]

    Alvisi, Lorenzo

    ,10)-encoded storage in this system results in hundreds of terabytes of daily recovery traffic through Top- Of an energy-conserving, storage-efficient, hybrid hadoop compute cluster. In Proceedings of the 2010Lazy Means Smart: Reducing Repair Bandwidth Costs in Erasure-coded Distributed Storage Mark

  12. FFaacciilliittiieess MMaannaaggeemmeenntt//EEnnvviirroonnmmeennttaall HHeeaalltthh && SSaaffeettyy Hazardous Work Area/Equipment Repair Form

    E-Print Network [OSTI]

    Mojzsis, Stephen J.

    Hazardous Work Area/Equipment Repair Form Form Instructions: Client is responsible for completing this form to assure that equipment and/or immediate work areas are not contaminated with any hazardous materials, tissue, etc.) Do Safety Hazards exist in the work area? N ___ Y ___ (Electrical, burn, or trip hazards

  13. Fast Interactive Simulations of Mitral Valve Repair Neil A. Tenenholtz, Peter E. Hammer, Robert D. Howe

    E-Print Network [OSTI]

    Fast Interactive Simulations of Mitral Valve Repair Neil A. Tenenholtz, Peter E. Hammer, Robert D. Howe Keywords: Surgical simulation, human-computer interaction, haptics, mitral valve, cardiac surgery. I. Problem Solved A healthy mitral valve ensures the one-way flow of oxygenated blood from the left

  14. Repair and Replacement projects help FM to honor its commitment to

    E-Print Network [OSTI]

    Gulliver, Robert

    of the University. Services provided fall into three major categories: preventive maintenance, routine repairs friendly power. Energy Management is continually recognized for the superior maintenance. · Maintenance (www.facm.umn. edu/services/maintenance.html) Maintenance Operations preserves the physical assets

  15. Home Maintenance and Repair Owning a home is a major responsibility.

    E-Print Network [OSTI]

    maintenance is conducted. Regular, preventive maintenance can pay off in peace of mind, utility cost savings, routine maintenance helps to prolong the life of the home and may prevent the need for major repairs of Benjamin Franklin, "An ounce of prevention is worth a pound of cure." Regular, routine maintenance enhances

  16. Investigation of Corrosion Damage and Repair System in a Concrete Jetty Structure

    E-Print Network [OSTI]

    Mobasher, Barzin

    Investigation of Corrosion Damage and Repair System in a Concrete Jetty Structure Farid Moradi of the deterioration was reinforcement corrosion, which initiated within few years after the completion of the jetty structure. The structure underwent major corrosion rehabilitation after 7 years of service. Despite the use

  17. Development/Plasticity/Repair The Bone Morphogenetic Protein Roof Plate Chemorepellent

    E-Print Network [OSTI]

    Butler, Samantha

    Development/Plasticity/Repair The Bone Morphogenetic Protein Roof Plate Chemorepellent Regulates, Toronto, Ontario, Canada M5G 1X8 Commissural spinal axons extend away from the roof plate (RP) in response to the dorsal midline and are generated by the bone morphogenetic proteins (BMPs) in the roof plate (RP) (Liem

  18. Development/Plasticity/Repair A Structural MRI Study of Human Brain Development from

    E-Print Network [OSTI]

    Utah, University of

    Development/Plasticity/Repair A Structural MRI Study of Human Brain Development from Birth to 2 Carolina, Chapel Hill, North Carolina 27599-7510 Brain development in the first 2 years after birth and schizophrenia. Knowledge regarding this period is currently quite limited. We studied structural brain

  19. Efficacy of Low Level Laser Therapy After Hand Flexor Tendon Repair

    SciTech Connect (OSTI)

    Ayad, K. E.; Abd El Mejeed, S. F. [Faculty of Physical Therapy, Cairo University (Egypt); El Gohary, H. M.; Abd Elrahman, M.; Bekheet, A. B. [Al Sahel Teaching Hospital, Cairo (Egypt)

    2009-09-27T23:59:59.000Z

    Flexor tendon injury is a common problem requiring suturing repair followed by early postoperative mobilization. Muscle atrophy, joint stiffness, osteoarthritis, infection, skin necrosis, ulceration of joint cartilage and tendocutaneous adhesion are familiar complications produced by prolonged immobilization of surgically repaired tendon ruptures. The purpose of this study was to clarify the importance of low level laser therapy after hand flexor tendon repair in zone II. Thirty patients aging between 20 and 40 years were divided into two groups. Patients in group A (n = 15) received a conventional therapeutic exercise program while patients in group B (n = 15) received low level laser therapy combined with the same therapeutic exercise program. The results showed a statistically significant increase in total active motion of the proximal and distal interphalangeal joints as well as maximum hand grip strength at three weeks and three months postoperative, but improvement was more significant in group B. It was concluded that the combination of low level laser therapy and early therapeutic exercises was more effective than therapeutic exercises alone in improving total active motion of proximal and distal interphalangeal joints and hand grip strength after hand flexor tendon repair.

  20. Provably Repairing the ISO/IEC 9798 Standard for Entity Authentication

    E-Print Network [OSTI]

    Basin, David

    , or authentication of transmitted data [27,33]. The ISO (International Organization for Standardization) and IECProvably Repairing the ISO/IEC 9798 Standard for Entity Authentication David Basin, Cas Cremers the family of entity authentication protocols defined by the ISO/IEC 9798 standard and find numerous

  1. Provably Repairing the ISO/IEC 9798 Standard for Entity Authentication

    E-Print Network [OSTI]

    Basin, David

    (International Organization for Standardization) and IEC (Interna- tional Electrotechnical Commission) jointlyProvably Repairing the ISO/IEC 9798 Standard for Entity Authentication David Basin, Cas Cremers the family of entity authentication proto- cols defined by the ISO/IEC 9798 standard and find numerous

  2. Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction1

    E-Print Network [OSTI]

    Stuart, Jeffrey A.

    Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction1 of Biology, Brock University, St. Catharines, Ontario, Canada; and Gazi University, Faculty of Pharmacy in kidney mitochondria. 4. CR increases nuclear BER activity BER activity and the activities of proteins

  3. Development/Plasticity/Repair Dendritic Spine Dynamics Regulate the Long-Term Stability

    E-Print Network [OSTI]

    van Rossum, Mark

    Development/Plasticity/Repair Dendritic Spine Dynamics Regulate the Long-Term Stability of Synaptic Plasticity Cian O'Donnell,1,2 Matthew F. Nolan,3 and Mark C. W. van Rossum1 1Institute for Adaptive of Edinburgh, Edinburgh EH8 9XD, United Kingdom Long-term synaptic plasticity requires postsynaptic influx

  4. Development/Plasticity/Repair A Refractory Period for Rejuvenating GABAergic Synaptic

    E-Print Network [OSTI]

    Gruner, Daniel S.

    Development/Plasticity/Repair A Refractory Period for Rejuvenating GABAergic Synaptic Transmission and Ocular Dominance Plasticity with Dark Exposure Shiyong Huang,1* Yu Gu,2* Elizabeth M. Quinlan,2 Dark exposure initiated in adulthood reactivates robust ocular dominance plasticity in the visual

  5. Development/Plasticity/Repair Simultaneous NMDA-Dependent Long-Term Potentiation of

    E-Print Network [OSTI]

    Segal, Menahem

    Development/Plasticity/Repair Simultaneous NMDA-Dependent Long-Term Potentiation of EPSCs and Long activity-dependent long-term plasticity of neuronal networks is the interplay between excitatory, whereas a nitric oxide synthase inhibitor was ineffec- tive. Finally, network-induced plasticity

  6. The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber Assembly

    E-Print Network [OSTI]

    Mecham, Robert

    The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber Assembly Adrian Shifren and Robert P properties of the lung are largely determined by the connective tissue networks laid down during development. The macromolecules most important for lung mechanics and structural integrity are collagen, elastin

  7. Development/Plasticity/Repair Identification of Modulators of Hair Cell Regeneration in the

    E-Print Network [OSTI]

    Rubel, Edwin

    Development/Plasticity/Repair Identification of Modulators of Hair Cell Regeneration compounds that modulate hair cell regeneration in zebrafish. Of the 1680 compounds evaluated, we identified,aresyntheticglucocorticoidsthatpotentiatedhaircellnumbersduringregenerationandalsoinducedhair cell addition in the absence of damage. BrdU analysis confirmed that the extra hair cells arose from

  8. Development/Plasticity/Repair Hair Cell Replacement in Adult Mouse Utricles after

    E-Print Network [OSTI]

    Rubel, Edwin

    Development/Plasticity/Repair Hair Cell Replacement in Adult Mouse Utricles after Targeted Ablation of Hair Cells with Diphtheria Toxin Justin S. Golub,1 Ling Tong,1 Tot B. Ngyuen,1 Cliff R. Hume,1 Richard developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse

  9. Breaking the Diffraction Barrier in Fluorescence Microscopy by Optical Shelving Stefan Bretschneider, Christian Eggeling, and Stefan W. Hell*

    E-Print Network [OSTI]

    Weeks, Eric R.

    Breaking the Diffraction Barrier in Fluorescence Microscopy by Optical Shelving Stefan the breaking of the diffraction resolution barrier in far-field fluorescence microscopy by transiently shelving barrier by shelving the fluorophore in a metastable dark state, thereby effectively depleting

  10. C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin

    SciTech Connect (OSTI)

    Liu, Sicheng; Liu, Xunyue; Kamdar, Radhika Pankaj; Wanotayan, Rujira; Sharma, Mukesh Kumar [Research Laboratory for Nuclear Reactors and Department of Nuclear Engineering, Graduate School of Science and Engineering, Tokyo Institute of Technology, Tokyo 152-8550 (Japan)] [Research Laboratory for Nuclear Reactors and Department of Nuclear Engineering, Graduate School of Science and Engineering, Tokyo Institute of Technology, Tokyo 152-8550 (Japan); Adachi, Noritaka [Graduate School of Nanobioscience, Yokohama City University, Yokohama 236-0027 (Japan)] [Graduate School of Nanobioscience, Yokohama City University, Yokohama 236-0027 (Japan); Matsumoto, Yoshihisa, E-mail: yoshim@nr.titech.ac.jp [Research Laboratory for Nuclear Reactors and Department of Nuclear Engineering, Graduate School of Science and Engineering, Tokyo Institute of Technology, Tokyo 152-8550 (Japan)] [Research Laboratory for Nuclear Reactors and Department of Nuclear Engineering, Graduate School of Science and Engineering, Tokyo Institute of Technology, Tokyo 152-8550 (Japan)

    2013-09-20T23:59:59.000Z

    Highlights: •Chromatin binding of XRCC4 is dependent on the presence of DNA ligase IV. •C-terminal region of DNA ligase IV alone can recruit itself and XRCC4 to chromatin. •Two BRCT domains of DNA ligase IV are essential for the chromatin binding of XRCC4. -- Abstract: DNA ligase IV (LIG4) and XRCC4 form a complex to ligate two DNA ends at the final step of DNA double-strand break (DSB) repair through non-homologous end-joining (NHEJ). It is not fully understood how these proteins are recruited to DSBs. We recently demonstrated radiation-induced chromatin binding of XRCC4 by biochemical fractionation using detergent Nonidet P-40. In the present study, we examined the role of LIG4 in the recruitment of XRCC4/LIG4 complex to chromatin. The chromatin binding of XRCC4 was dependent on the presence of LIG4. The mutations in two BRCT domains (W725R and W893R, respectively) of LIG4 reduced the chromatin binding of LIG4 and XRCC4. The C-terminal fragment of LIG4 (LIG4-CT) without N-terminal catalytic domains could bind to chromatin with XRCC4. LIG4-CT with W725R or W893R mutation could bind to chromatin but could not support the chromatin binding of XRCC4. The ability of C-terminal region of LIG4 to interact with chromatin might provide us with an insight into the mechanisms of DSB repair through NHEJ.

  11. Spontaneous Symmetry Breaking as a Basis of Particle Mass

    SciTech Connect (OSTI)

    Quigg, Chris; /Fermilab /CERN

    2007-04-01T23:59:59.000Z

    Electroweak theory joins electromagnetism with the weak force in a single quantum field theory, ascribing the two fundamental interactions--so different in their manifestations--to a common symmetry principle. How the electroweak gauge symmetry is hidden is one of the most urgent and challenging questions facing particle physics. The provisional answer incorporated in the ''standard model'' of particle physics was formulated in the 1960s by Higgs, by Brout & Englert, and by Guralnik, Hagen, & Kibble: The agent of electroweak symmetry breaking is an elementary scalar field whose self-interactions select a vacuum state in which the full electroweak symmetry is hidden, leaving a residual phase symmetry of electromagnetism. By analogy with the Meissner effect of the superconducting phase transition, the Higgs mechanism, as it is commonly known, confers masses on the weak force carriers W{sup {+-}} and Z. It also opens the door to masses for the quarks and leptons, and shapes the world around us. It is a good story--though an incomplete story--and we do not know how much of the story is true. Experiments that explore the Fermi scale (the energy regime around 1 TeV) during the next decade will put the electroweak theory to decisive test, and may uncover new elements needed to construct a more satisfying completion of the electroweak theory. The aim of this article is to set the stage by reporting what we know and what we need to know, and to set some ''Big Questions'' that will guide our explorations.

  12. The effects of similarity breaking on the intracluster medium

    E-Print Network [OSTI]

    E. J. Lloyd-Davies; R. G. Bower; T. J. Ponman

    2002-03-28T23:59:59.000Z

    We construct a family of simple analytical models of galaxy clusters at the present epoch and compare its predictions with observational data. We explore two processes that break the self-similarity of galaxy clusters: systematic variation in the dark matter halo concentration and energy injection into the intracluster gas, through their effects on the observed cluster properties. Three observed relations between cluster properties and temperature are employed to constrain the model; mass, slope of gas density profile (beta) and luminosity. The slope of the mass-temperature relation is found to be reproduced by our model when the observed variation in concentration is included, raising the slope from the self-similar prediction of 1.5, to that of the observed relation, ~ 2. Heating of the gas is observed to have little effect on the mass-temperature relation. The mean trend in the beta-temperature relation is reproduced by energy injection of 0.5-0.75 keV per particle, while concentration variation has only a small effect. Excess energies calculated for individual systems from the beta-temperature relation suggest that the lowest mass systems may have excess energies that are biased to lower values by selection effects. The observed properties of the luminosity-temperature relation are reproduced by the combined effects of excess energy and a trend in the dark matter concentration. At high masses the observed variation in dark matter concentration results a slope of ~ 2.7 compared to recent observations in the range 2.6-2.9, whilst the observed steepening in galaxy groups is predicted when heating of 0.5-0.75 keV per particle is included. Hence a combination of energy injection and dark matter concentration variation appears able to account for the mean trends in the observed relations.

  13. ADVANCES IN ATMOSPHERIC SCIENCES, VOL. 26, NO. 4, 2009, 701706 Variability of Northeast China River Break-up Date

    E-Print Network [OSTI]

    River Break-up Date WANG Huijun1,2 ( ˇ) and SUN Jianqi1,2 (ę ) 1 Institute of Atmospheric Physics investigates the variability of the break-up dates of the rivers in Northeast China from their icebound states for the period of 1957­2005 and explores some potential explanatory mechanisms. Results show that the break-up

  14. An adaptive time-space dual algorithm for shallow non-Newtonian power-law fluids: the horizontal dam break

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    dam break problem revisited P. Saramito a C. Smutek b B. Cordonnier b aLJK ­ CNRS et Universit´es de´eunion, France Abstract ­ The dam break problem shallow approximation for laminar flows of viscoplastic non equations for non-Newtonian fluids subject to the horizontal dam break problem. Keywords ­ viscoplastic

  15. Small break critical discharge: The roles of vapor and liquid entrainment in a stratified two-phase region upstream of the break

    SciTech Connect (OSTI)

    Schrock, V E; Revankar, S T; Mannheimer, R; Wang, C H

    1986-12-01T23:59:59.000Z

    The main objective of this research program was to perform an experimental investigation on the phenomena of two-phase critical flow through small break from a horizontal pipe which contained a stratified two phase flow. Stagnation conditions investigated were saturated steam-water, and air-cold water at pressures ranging from 0.37 MPa to 1.07 MPa. The small breaks employed were cylindrical tubes of diameters 3.96 mm, 6.32 mm, and 10.1 mm with sharp-edged entrance. For breaks resulting from a small hole in a primary coolant pipe or in a small pipe, a sharp-edged orifice or a sharp-edged tube can be the approximation.

  16. Double Ended Guillotine Break in a Prismatic Block VHTR Lower Plenum Air Ingress Scenario

    E-Print Network [OSTI]

    Hartley, Jessica

    2012-10-19T23:59:59.000Z

    The double ended guillotine break leading to density-driven air ingress has been identified as a low probability yet high consequence event for Very High Temperature Reactor (VHTR). The lower plenum of the VHTR contains the core support structure...

  17. Physics and learning based computational models for breaking bow waves based on new boundary immersion approaches

    E-Print Network [OSTI]

    Weymouth, Gabriel David

    2008-01-01T23:59:59.000Z

    A ship moving on the free surface produces energetic breaking bow waves which generate spray and air entrainment. Present experimental, analytic, and numerical studies of this problem are costly, inaccurate and not robust. ...

  18. Electroweak symmetry breaking in the era of the Higgs boson discovery

    E-Print Network [OSTI]

    Bertolini, Daniele, Ph. D. Massachusetts Institute of Technology

    2014-01-01T23:59:59.000Z

    In this thesis we study possible deviations from the electroweak symmetry breaking mechanism as predicted by the Standard Model (SM), and we introduce a new framework to analyze hadronic final states at colliders. In the ...

  19. Introduction of Break-Out Session at the International PV Module Quality Assurance Forum (Presentation)

    SciTech Connect (OSTI)

    Kurtz, S.; Wohlgemuth, J.; Yamamichi, M.; Sample, T.

    2011-07-01T23:59:59.000Z

    This presentation outlines review requirements for quality assurance (QA) rating systems, logical design of QA systems, and specific tasks for break-out session 1 of the 2011 International PV Module Quality Assurance Forum.

  20. Design Considerations for Monopile Founded Offshore Wind Turbines Subject to Breaking Waves

    E-Print Network [OSTI]

    Owens, Garrett Reese 1987-

    2012-11-26T23:59:59.000Z

    The majority of offshore wind farms utilize monopile substructures. As these wind farms are typically located in water depths less than 30 meters, the effect of breaking waves on these structures is of great concern to design engineers...

  1. Double Ended Guillotine Break in a Prismatic Block VHTR Lower Plenum Air Ingress Scenario 

    E-Print Network [OSTI]

    Hartley, Jessica

    2012-10-19T23:59:59.000Z

    and is composed of graphite. During an air ingress event, oxidation of the graphite structure under high temperature conditions in an oxygen containing environment could degrade the integrity of the core support structure. Following this large break, air from...

  2. Design Considerations for Monopile Founded Offshore Wind Turbines Subject to Breaking Waves 

    E-Print Network [OSTI]

    Owens, Garrett Reese 1987-

    2012-11-26T23:59:59.000Z

    The majority of offshore wind farms utilize monopile substructures. As these wind farms are typically located in water depths less than 30 meters, the effect of breaking waves on these structures is of great concern to design engineers...

  3. SU(3) and Isospin Breaking Effects on B to PPP Amplitudes

    E-Print Network [OSTI]

    Xiao-Gang He; Guan-Nan Li; Dong Xu

    2015-03-05T23:59:59.000Z

    Several modes of $B$ decays into three pseudoscalar octet mesons PPP have been measured. These decays have provided useful information for B decays in the standard model (SM). Some of powerful tools in analyzing B decays are flavor $SU(3)$ and isospin symmetries. Such analyses are usually hampered by $SU(3)$ breaking effects due to a relatively large strange quark mass which breaks SU(3) symmetry down to isospin symmetry. The isospin symmetry also breaks down when up and down quark mass difference is non-zero. It is therefore interesting to find relations which are not sensitive to $SU(3)$ and isospin breaking effects. We find that the relations among several fully-symmetric $B \\to PPP$ decay amplitudes are not affected by first order $SU(3)$ breaking effects due to a non-zero strange quark mass, and also some of them are not affected by first isospin breaking effects. These relations, therefore, hold to good precisions. Measurements for these relations can provide important information about B decays in the SM.

  4. Assessing the Risk of Mercury in Drinking Water after UV Lamp Breaks Page 1 Assessing the Risk of Mercury in Drinking Water after UV Lamp Breaks

    E-Print Network [OSTI]

    energy through temperature and pressure to drive the mercury into a vapor phase. Mercury is a heavy metal, and is regulated in drinking water by the EPA through the Safe Drinking Water Act (SDWA). If an on-line lamp break historically the U.S. has been skeptical to implement UV into drinking water systems, many areas of Europe

  5. Using Differential Adhesion to Control Self-Assembly and Self-Repair of Collections of Modular Mobile Robots 

    E-Print Network [OSTI]

    Ottery, Peter

    This thesis presents a novel distributed control method which allows a collection of independently mobile robotic units, with two or three dimensional movement, to self-assemble into self-repairing hierarchical structures. ...

  6. The role of vascular endothelial growth factor (VEGF) in repair and recovery from acute respiratory distress syndrome (ARDS) 

    E-Print Network [OSTI]

    Medford, Andrew R.L

    2007-01-01T23:59:59.000Z

    Acute Respiratory Distress Syndrome (ARDS) is the most extreme form of acute lung injury and continues to have a significant morbidity and mortality. Unfortunately, the mechanisms involved in the recovery and repair of ...

  7. Repair of localized defects in multilayer-coated reticle blanks for extreme ultraviolet lithography

    DOE Patents [OSTI]

    Stearns, Daniel G. (Los Altos, CA); Sweeney, Donald W. (San Ramon, CA); Mirkarimi, Paul B. (Sunol, CA)

    2004-11-23T23:59:59.000Z

    A method is provided for repairing defects in a multilayer coating layered onto a reticle blank used in an extreme ultraviolet lithography (EUVL) system. Using high lateral spatial resolution, energy is deposited in the multilayer coating in the vicinity of the defect. This can be accomplished using a focused electron beam, focused ion beam or a focused electromagnetic radiation. The absorbed energy will cause a structural modification of the film, producing a localized change in the film thickness. The change in film thickness can be controlled with sub-nanometer accuracy by adjusting the energy dose. The lateral spatial resolution of the thickness modification is controlled by the localization of the energy deposition. The film thickness is adjusted locally to correct the perturbation of the reflected field. For example, when the structural modification is a localized film contraction, the repair of a defect consists of flattening a mound or spreading out the sides of a depression.

  8. Nondestructive evaluation and characterization of damage and repair to continuous-fiber ceramic composite panels.

    SciTech Connect (OSTI)

    Sun, J. G.; Petrak, D. R.; Pillai, T. A. K.; Deemer, C.; Ellingson, W. A.

    1998-04-01T23:59:59.000Z

    Continuous fiber ceramic matrix composites are currently being developed for a variety of high-temperature applications. Because of the high costs of making these components, minor damage incurred during manufacturing or operation must be rewired in order to extend the life of the components. In this study, five ceramic-grade Nicalon{trademark} fiber/SiNC-matrix composite panels were intentionally damaged with a pendulum-type impactor during an impact test. The damaged panels were then repaired at Dow Corning Corporation. Three nondestructive evaluation (NDE) methods were used to study the characteristics of the panels after the damage and again after the panels were repaired. The NDE methods were X-ray radiography, infrared thermal imaging, and air-coupled ultrasound. The results showed that the impact test induced various types of damage in the panels. The NDE data that were obtained by the three NDE methods were correlated with each other.

  9. Weld Repair of a Stamped Pressure Vessel in a Radiologically Controlled Zone

    SciTech Connect (OSTI)

    Cannell, Gary L. [Fluor Enterprises, Inc.; Huth, Ralph J. [CH2MHill Plateau Remediation Company; Hallum, Randall T. [Fluor Government Group

    2013-08-26T23:59:59.000Z

    In September 2012 an ASME B&PVC Section VIII stamped pressure vessel located at the DOE Hanford Site Effluent Treatment Facility (ETF) developed a through-wall leak. The vessel, a steam/brine heat exchanger, operated in a radiologically controlled zone (by the CH2MHill PRC or CHPRC), had been in service for approximately 17 years. The heat exchanger is part of a single train evaporator process and its failure caused the entire system to be shut down, significantly impacting facility operations. This paper describes the activities associated with failure characterization, technical decision making/planning for repair by welding, logistical challenges associated with performing work in a radiologically controlled zone, performing the repair, and administrative considerations related to ASME code requirements.

  10. Subterranean barriers, methods, and apparatuses for forming, inspecting, selectively heating, and repairing same

    DOE Patents [OSTI]

    Nickelson, Reva A. (Shelley, ID); Sloan, Paul A. (Rigby, ID); Richardson, John G. (Idaho Falls, ID); Walsh, Stephanie (Idaho Falls, ID); Kostelnik, Kevin M. (Idaho, ID)

    2009-04-07T23:59:59.000Z

    A subterranean barrier and method for forming same are disclosed, the barrier including a plurality of casing strings wherein at least one casing string of the plurality of casing strings may be affixed to at least another adjacent casing string of the plurality of casing strings through at least one weld, at least one adhesive joint, or both. A method and system for nondestructively inspecting a subterranean barrier is disclosed. For instance, a radiographic signal may be emitted from within a casing string toward an adjacent casing string and the radiographic signal may be detected from within the adjacent casing string. A method of repairing a barrier including removing at least a portion of a casing string and welding a repair element within the casing string is disclosed. A method of selectively heating at least one casing string forming at least a portion of a subterranean barrier is disclosed.

  11. Template strand scrunching during DNA gap repair synthesis by human polymerase [lamda

    SciTech Connect (OSTI)

    Garcia-Diaz, Miguel; Bebenek, Katarzyna; Larrea, Andres A.; Havener, Jody M.; Perera, Lalith; Krahn, Joseph M.; Pedersen, Lars C.; Ramsden, Dale A.; Kunkel, Thomas A.; (NIH); (UNC)

    2009-09-25T23:59:59.000Z

    Family X polymerases such as DNA polymerase {lambda}(Pol {lambda}) are well suited for filling short gaps during DNA repair because they simultaneously bind both the 5{prime} and 3{prime} ends of short gaps. DNA binding and gap filling are well characterized for 1-nucleotide (nt) gaps, but the location of yet-to-be-copied template nucleotides in longer gaps is unknown. Here we present crystal structures revealing that, when bound to a 2-nt gap, Pol {lambda} scrunches the template strand and binds the additional uncopied template base in an extrahelical position within a binding pocket that comprises three conserved amino acids. Replacing these amino acids with alanine results in less processive gap filling and less efficient NHEJ when 2-nt gaps are involved. Thus, akin to scrunching by RNA polymerase during transcription initiation, scrunching occurs during gap filling DNA synthesis associated with DNA repair.

  12. "You Can Do It" Basic Home Repair Using Hand and Power Tools

    E-Print Network [OSTI]

    1 "You Can Do It" Basic Home Repair Using Hand and Power Tools by Janie L. Harris Extension Housing guard housing. Place the tool rest 1/8 inch from the wheel on bench-mounted units. Before starting://www.cdc.gov/nasd/docs/ University of Denver, Risk Management http://www.du.edu/risk/Tool_Safety.html #12;2 "You Can Do It" Basic

  13. The strengthening and repair of underground structures: A new approach to the management of nuclear waste

    SciTech Connect (OSTI)

    Colgate, S.A.

    1991-01-01T23:59:59.000Z

    This paper presents three closely related ideas and technologies: (1) The secure, repairable, long time confinement of nuclear radioactive waste underground by a large surrounding region of compressive overstress; (2) The inherent tectonic weakness and vulnerability of the normal underground environment and its modification by overstress; (3) The process of creating overstress by the sequential periodic high pressure injection of a finite gel strength rapid setting grout. 12 refs., 6 figs.

  14. Note: A Graph-Theoretical Approach to Level of Repair Analysis

    E-Print Network [OSTI]

    2004-08-29T23:59:59.000Z

    Aug 29, 2004 ... cilities to minimize overall life-cycle costs. ... decisions, LORA seeks to determine an optimal provision of repair and maintenance ... Their heuristic is based on a relaxation of LORA into a pair of ... R2 is a consequence of R1 and a policy of .... from the fact that one can find a minimum cut in N(B) in time O(n2.

  15. Development program to certify composite doubler repair technique for commercial aircraft

    SciTech Connect (OSTI)

    Roach, D.P.

    1997-07-01T23:59:59.000Z

    Commercial airframes exceeding 20 service years often develop crack and corrosion flaws. Bonded composite doublers offer a cost effective method to safely extend aircraft lives. The Federal Aircraft Authority (FAA) has completed a project to introduce composite doubler repair technology to the commercial aircraft industry. Instead of riveting steel or aluminum plates for repair, a single composite doubler may be bonded to the damaged structure. Adhesive bonding eliminates stress concentrations caused by fastener holes. Composites are readily formed into complex shapes for repairing irregular components. Also, composite doublers can be tailored to meet specific anisotropy needs, eliminating structural stiffening in directions other than those required. Other advantages include corrosion resistance, a high strength-to-weight ratio, and potential time savings in installation. One phase of this study developed general methodologies and test programs to ensure proper performance of the technique. A second phase focused on reinforcement of an L-1011 door frame, and encompassed all lifetime tasks such as design, analysis, installation, and nondestructive inspection. This paper overviews the project and details the activities conducted to gain FAA approval for composite doubler use. Structural tests evaluated the damage tolerance and fatigue performance of composite doublers while finite element models were generated to study doubler design issues. Nondestructive inspection procedures were developed and validated using full-scale test articles. Installation dry-runs demonstrated the viability of applying composite doublers in hangar environments. The project`s documentation package was used to support installation of a Boron-Epoxy composite repair on a Delta Air Lines L-1011 aircraft. A second product of the results is a Lockheed Service Bulletin which allows the door corner composite doubler to be installed on all L-1011 aircraft. 9 refs., 10 figs., 2 tabs.

  16. Lethal Hemorrhage Caused by Aortoesophageal Fistula Secondary to Stent-Graft Repair of the Thoracic Aorta

    SciTech Connect (OSTI)

    Sager, Hendrik B., E-mail: hendrik.sager@uk-sh.de [Universitaet zu Luebeck, Medizinische Klinik II (Germany); Wellhoener, Peter [Universitaet zu Luebeck, Medizinische Klinik I (Germany); Wermelt, Johanna A. [Klinikum Neustadt, Klinik fuer Innere Medizin (Germany); Schunkert, Heribert; Kurowski, Volkhard [Universitaet zu Luebeck, Medizinische Klinik II (Germany)

    2011-02-15T23:59:59.000Z

    Aortoesophageal fistula (AEF) is a rare but life-threatening complication after endovascular or surgical aortic repair. Here we report a patient with AEF secondary to aortic stent-placement 2 years earlier who presented with hematemesis and died from hemorrhagic shock. By means of this case and the literature, we highlight potential bleeding sources in such a scenario because this is of crucial importance for the management strategy.

  17. REPAIR OF A DAMAGED PART ON HYDRAULIC TRACT KAPLAN TURBINE WITH "LIQUID METAL"

    E-Print Network [OSTI]

    Fuad ?atovi?; Prof Emeritus; Edin Džiho Msc; Mostar Bih; Mustafa Šehi?; Hydroelectric Power Plant Neretva; Jablanica Bih

    During 2011 on unit no.2 reparation work was carried out aimed at fault removal on Kaplan turbine impeller, while extending the lifespan of the entire installed equipment. The overhaul included all vital parts, replacement of all gasket compresses, machine processing to achieve the required tolerances, NDT equipment control according to "Quality Control Plan", repairing equipment, etc. This paper describes the recovery of defects on the blades of the guide vanes using epoxy masses.

  18. Endovascular Repair of a Pseudoaneurysm of the Abdominal Aorta Secondary to Translumbar Aortography

    SciTech Connect (OSTI)

    Mir, Naheed; Nunzio, Mario De; Pollock, John G [Derbyshire Royal Infirmary, Department of Clinical Radiology (United Kingdom)], E-mail: JG.Pollock@derbyhospitals.nhs.uk

    2006-12-15T23:59:59.000Z

    This report describes an incidental finding of a pseudoaneurysm of the abdominal aorta on a computed tomography (CT) renal angiogram during investigation of chronic renal failure in a 73-year-old man. The patient had undergone a translumbar aortogram 20 years previously. An increase in the size of the aneurysm by 7 mm over 6 months prompted treatment and the aneurysm underwent successful endovascular repair with a custom-made stent-graft.

  19. Plasma transferred arc repair welding of the nickel-base superalloy IN-738LC

    SciTech Connect (OSTI)

    Su, C.Y.; Chou, C.P. [National Chiao Tung Univ., Hsinchu (Taiwan, Province of China). Dept. of Mechanical Engineering; Wu, B.C.; Lih, W.C. [Industrial Technology Research Inst., Hsinchu (Taiwan, Province of China). Materials Research Labs.

    1997-10-01T23:59:59.000Z

    Plasma transferred arc welding (PTA) has been considered a promising process to restore worn areas of land-based gas turbine blades and vanes. The objective of this investigation was to study the effect of PTA welding on the repairing of IN-738LC superalloy components. Tensile tests were conducted on specimens welded with various combinations of parameters. Room temperature, 760 C, and 980 C were selected as tensile test temperatures. High-temperature phase transformed, during solidification, were identified by differential thermal analysis (DTA). The weld-pool shapes and microstructures of welded specimens prepared by various welding parameters were evaluated by optical metallography (OM), a scanning electron microscope (SEM) equipped with energy dispersive x-ray spectrometer (EDS), and microhardness testing. Results of this study showed that PTA welded specimens exhibited 96% nominal tensile strength of IN-738LC base materials. Specimen failure was observed predominantly in the base materials instead of in the heat-affected zone (HAZ) for gas tungsten arc weld (GTAW) repair weldments. IN-738LC is considered susceptible to weld cracking during fusion welding; however, using a low-input repair welding process (PTA), cracking susceptibility could be minimized by the optimized welding parameters.

  20. LENS repair and modification of metal NW components:materials and applications guide.

    SciTech Connect (OSTI)

    Smugeresky, John E. (Sandia National Laboratories, Livermore, CA); Gill, David Dennis; Oberhaus, Jason (BWXT Y-12); Adams, Thad (Savannah River National Laboratory); VanCamp, Chad (Kansas City Plant)

    2006-11-01T23:59:59.000Z

    Laser Engineered Net Shaping{trademark} (LENS{reg_sign}) is a unique, layer additive, metal manufacturing technique that offers the ability to create fully dense metal features and components directly from a computer solid model. LENS offers opportunities to repair and modify components by adding features to existing geometry, refilling holes, repairing weld lips, and many other potential applications. The material deposited has good mechanical properties with strengths typically slightly higher that wrought material due to grain refinement from a quickly cooling weld pool. The result is a material with properties similar to cold worked material, but without the loss in ductility traditionally seen with such treatments. Furthermore, 304L LENS material exhibits good corrosion resistance and hydrogen compatibility. This report gives a background of the LENS process including materials analysis addressing the requirements of a number of different applications. Suggestions are given to aid both the product engineer and the process engineer in the successful utilization of LENS for their applications. The results of testing on interface strength, machinability, weldability, corrosion resistance, geometric effects, heat treatment, and repair strategy testing are all included. Finally, the qualification of the LENS process is briefly discussed to give the user confidence in selecting LENS as the process of choice for high rigor applications. The testing showed LENS components to have capability in repair/modification applications requiring complex castings (W80-3 D-Bottle bracket), thin wall parts requiring metal to be rebuilt onto the part (W87 Firing Set Housing and Y-12 Test Rings), the filling of counterbores for use in reservoir reclamation welding (SRNL hydrogen compatibility study) and the repair of surface defects on pressure vessels (SRNL gas bottle repair). The material is machinable, as testing has shown that LENS deposited material machines similar to that of welded metal. Tool wear is slightly higher in LENS material than in wrought material, but not so much that one would be concerned with increased tooling cost. The LENS process achieved process qualification for the AY1E0125 D-Bottle Bracket from the W80-3 LEP program, and in the effort, also underwent testing in weapons environments. These tests included structural dynamic response testing and drop testing. The LENS deposited parts were compared in these tests with conventionally machined parts and showed equivalency to such an extent that the parts were accepted for use in parallel path subsystem-level weapon environment testing. The evaluation of LENS has shown that the process can be a viable option when either complete metal parts are needed or existing metal parts require modification or repair. The LENS Qualification Technology Investment team successfully investigated new applications for the LENS process and showed that it has great applicability across the Nuclear Weapons Complex as well as in other high rigor applications.

  1. The evolution of the break preclusion concept for nuclear power plants in Germany

    SciTech Connect (OSTI)

    Schulz, H. [Gesellschaft fuer Anlagen- und Reaktorsicherheit, Koeln (Germany)

    1997-04-01T23:59:59.000Z

    In the updating of the Guidelines for PWR`s of the {open_quotes}Reaktor-Sicherheitskommission{close_quotes} (RSK) in 1981 the requirements on the design have been changed with respect to the postulated leaks and breaks in the primary pressure boundary. The major change was a revision in the requirements for pipe whip protection. As a logical consequence of the {open_quotes}concept of basic safety{close_quotes} a guillotine type break or any other break type resulting in a large opening is not postulated any longer for the calculation of reaction and jet forces. As an upper limit for a leak an area of 0, 1 A (A = open cross section of the pipe) is postulated. This decision was based on a general assessment of the present PWR system design in Germany. Since then a number of piping systems have been requalified in the older nuclear power plants to comply with the break preclusion concept. Also a number of extensions of the concept have been developed to cover also leak-assumptions for branch pipes. Furthermore due considerations have been given to other aspects which could contribute to a leak development in the primary circuit, like vessel penetrations, manhole covers, flanges, etc. Now the break preclusion concept originally applied to the main piping has been developed into an integrated concept for the whole pressure boundary within the containment and will be applied also in the periodic safety review of present nuclear power plants.

  2. Effects of $?$-cluster breaking on 3$?$ cluster structures in $^{12}$C

    E-Print Network [OSTI]

    Tadahiro Suhara; Yoshiko Kanada-En'yo

    2015-02-17T23:59:59.000Z

    To clarify the effects of $\\alpha$-cluster breaking on 3$\\alpha$ cluster structures in $^{12}$C, we investigate $^{12}$C using a hybrid model that combines the Brink-Bloch cluster model with the $p_{3/2}$ subshell closure wave function. We have found that $\\alpha$-cluster breaking caused by spin-orbit force significantly changes cluster structures of excited $0^{+}$ states through orthogonality to lower states. Spatially developed cluster components of the $0^{+}_{2}$ state are reduced. The $0^{+}_{3}$ state changes from a vibration mode in the bending motion of three $\\alpha$ clusters to a chain-like 3$\\alpha$ structure having an open triangle configuration. As a result of these structure changes of $0^{+}$ states, the band assignment for the $2^{+}_{2}$ state is changed by the $\\alpha$-cluster breaking effect. Namely, in model calculations without the $\\alpha$-cluster breaking effect, the $0^{+}_{2}$ state is assigned to be the band-head of the $2^{+}_{2}$ state. However, when we incorporate $\\alpha$-cluster breaking caused by the spin-orbit force, the $0^{+}_{3}$ state is regarded as the band-head of the $2^{+}_{2}$ state.

  3. Gaugino Condensation, S-Duality and Supersymmetry Breaking in Supergravity Models

    E-Print Network [OSTI]

    Z. Lalak; A. Niemeyer; H. P. Nilles

    1995-04-07T23:59:59.000Z

    The status of the gaugino condensation as the source of supersymmetry breaking is reexamined. It is argued that one cannot have stable minima with broken supersymmetry in models where the dilaton is coupled only linearly to the gaugino condensate. We show that the problems of the gaugino condensate mechanism can be solved by considering nonstandard gauge kinetic functions, created by nonperturbative effects. As an example we use the principle of S-duality to modify the coupling of the gaugino condensate to effective supergravity (superstring) Lagrangians. We show that such an approach can solve the problem of the runaway dilaton and lead to satisfactory supersymmetry breaking in models with a {\\em single} gaugino condensate. We exhibit a general property of theories containing a symmetry acting on the dilaton and also shed some light on the question whether it is generically the auxiliary field of the modulus $T$, which dominates supersymmetry breaking.

  4. Proposal to negotiate two contracts, without competitive tendering, for the supply and the repair of compressors for the LHC 18 kW helium refrigeration plants

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    Proposal to negotiate two contracts, without competitive tendering, for the supply and the repair of compressors for the LHC 18 kW helium refrigeration plants

  5. Building a market for small wind: The break-even turnkey cost of residential wind systems in the United States

    E-Print Network [OSTI]

    Edwards, Jennifer L.; Wiser, Ryan; Bolinger, Mark; Forsyth, Trudy

    2004-01-01T23:59:59.000Z

    Break-Even Turnkey Cost of Residential Wind Systems in theaggregate installed cost of a small wind system that couldand wind resource class, (2) significant cost reductions

  6. Wave breaking phenomenon of lower-hybrid oscillations induced by a background inhomogeneous magnetic field

    SciTech Connect (OSTI)

    Maity, Chandan; Chakrabarti, Nikhil [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064 (India); Sengupta, Sudip [Institute for Plasma Research, Bhat, Gandhinagar 382428 (India)

    2012-10-15T23:59:59.000Z

    In a fluid description, we study space-time evolution of lower hybrid modes in a cold quasi-neutral homogeneous plasma in presence of a background inhomogeneous magnetic field. Within a linear analysis, a dispersion relation with inhomogeneous magnetic field shows 'phase mixing' of such oscillations. A manifestation of 'phase mixing' is shown in 'mode coupling.' By using Lagrangian variables, an exact solution is presented in parametric form of this nonlinear time dependent problem. It is demonstrated that initially excited lower hybrid modes always break via phase mixing phenomenon in presence of an inhomogeneous magnetic field. Breaking of such oscillations is revealed by the appearance of spikes in the plasma density profile.

  7. Semiclassical treatment of symmetry breaking and bifurcations in a non-integrable potential

    E-Print Network [OSTI]

    M. V. Koliesnik; Ya. D. Krivenko-Emetov; A. G. Magner; K. Arita; M. Brack

    2014-11-10T23:59:59.000Z

    We have derived an analytical trace formula for the level density of the H\\'enon-Heiles potential using the improved stationary phase method, based on extensions of Gutzwiller's semiclassical path integral approach. This trace formula has the correct limit to the standard Gutzwiller trace formula for the isolated periodic orbits far from all (critical) symmetry-breaking points. It continuously joins all critical points at which an enhancement of the semiclassical amplitudes occurs. We found a good agreement between the semi- classical and the quantum oscillating level densities for the gross shell structures and for the energy shell corrections, solving the symmetry breaking problem at small energies.

  8. Frequency-doubled scattering of symmetry-breaking surface-state electrons on liquid Helium

    E-Print Network [OSTI]

    Miao Zhang; Wenzhi Jia; Lianfu Wei

    2013-03-18T23:59:59.000Z

    Any systems with symmetry-breaking eigenstates can effectively radiate photons with doubled frequency of the incident light, which is known as the second harmonic generation. Here, we study the second-order nonlinear effects with the system of surface-state electrons on liquid Helium. Due to the symmetry-breaking eigenstates, we show that a Rabi oscillation between two levels of the surface-state electrons can be realized beyond the usual resonant driving. Consequently, an electromagnetic field with the doubled frequency of the applied driving could be effectively radiated. This can be regarded as a frequency-doubled fluorescence, and interestingly, it works in the unusual Terahertz range.

  9. Symmetry breaking patterns and collective modes of spin-one color superconductors

    E-Print Network [OSTI]

    Tomas Brauner; Jin-yi Pang; Qun Wang

    2009-09-23T23:59:59.000Z

    Spin-one color superconductor is a viable candidate phase of dense matter in the interiors of compact stars. Its low-energy excitations will influence the transport properties of such matter and thus have impact on late-stage evolution of neutron stars. It also provides a good example of spontaneous symmetry breaking with rich breaking patterns. In this contribution, we reanalyze the phase diagram of a spin-one color superconductor and point out that a part of it is occupied by noninert states, which have been neglected in literature so far. We classify the collective Nambu--Goldstone modes, which are essential to the transport phenomena.

  10. The concepts of leak before break and absolute reliability of NPP equipment and piping

    SciTech Connect (OSTI)

    Getman, A.F.; Komarov, O.V.; Sokov, L.M. [and others

    1997-04-01T23:59:59.000Z

    This paper describes the absolute reliability (AR) concept for ensuring safe operation of nuclear plant equipment and piping. The AR of a pipeline or component is defined as the level of reliability when the probability of an instantaneous double-ended break is near zero. AR analysis has been applied to Russian RBMK and VVER type reactors. It is proposed that analyses required for application of the leak before break concept should be included in AR implementation. The basic principles, methods, and approaches that provide the basis for implementing the AR concept are described.

  11. Role of space-time foam in breaking supersymmetry via the Barbero-Immirzi parameter

    SciTech Connect (OSTI)

    Ellis, John; Mavromatos, Nick E. [Theoretical Particle Physics and Cosmology Group, Department of Physics, King's College London, Strand, London WC2R 2LS, UK and Theory Division, Physics Department, CERN, CH-1211 Geneva 23 (Switzerland)

    2011-10-15T23:59:59.000Z

    We discuss how: (i) a dilaton/axion superfield can play the role of a Barbero-Immirzi field in four-dimensional conformal quantum supergravity theories, (ii) a fermionic component of such a dilaton/axion superfield may play the role of a Goldstino in the low-energy effective action obtained from a superstring theory with F-type global supersymmetry breaking, (iii) this global supersymmetry breaking is communicated to the gravitational sector via the supergravity coupling of the Goldstino, and (iv) such a scenario may be realized explicitly in a D-foam model with D-particle defects fluctuating stochastically.

  12. Multicritical Symmetry Breaking and Naturalness of Slow Nambu-Goldstone Bosons

    E-Print Network [OSTI]

    Tom Griffin; Kevin T. Grosvenor; Petr Horava; Ziqi Yan

    2013-09-02T23:59:59.000Z

    We investigate spontaneous global symmetry breaking in the absence of Lorentz invariance, and study technical Naturalness of Nambu-Goldstone (NG) modes whose dispersion relation exhibits a hierarchy of multicritical phenomena with Lifshitz scaling and dynamical exponents $z>1$. For example, we find NG modes with a technically natural quadratic dispersion relation which do not break time reversal symmetry and are associated with a single broken symmetry generator, not a pair. The mechanism is protected by an enhanced `polynomial shift' symmetry in the free-field limit.

  13. DNA Repair Biomarkers Predict Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer

    SciTech Connect (OSTI)

    Alexander, Brian M., E-mail: bmalexander@lroc.harvard.edu [Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (United States); Wang Xiaozhe [On-Q-ity, Inc., Waltham, Massachusetts (United States); Niemierko, Andrzej [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Weaver, David T. [On-Q-ity, Inc., Waltham, Massachusetts (United States); Mak, Raymond H. [Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (United States); Roof, Kevin S. [Southeast Radiation Oncology, Charlotte, North Carolina (United States); Fidias, Panagiotis [Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts (United States); Wain, John [Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts (United States); Choi, Noah C. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2012-05-01T23:59:59.000Z

    Purpose: The addition of neoadjuvant chemoradiotherapy prior to surgical resection for esophageal cancer has improved clinical outcomes in some trials. Pathologic complete response (pCR) following neoadjuvant therapy is associated with better clinical outcome in these patients, but only 22% to 40% of patients achieve pCR. Because both chemotherapy and radiotherapy act by inducing DNA damage, we analyzed proteins selected from multiple DNA repair pathways, using quantitative immunohistochemistry coupled with a digital pathology platform, as possible biomarkers of treatment response and clinical outcome. Methods and Materials: We identified 79 patients diagnosed with esophageal cancer between October 1994 and September 2002, with biopsy tissue available, who underwent neoadjuvant chemoradiotherapy prior to surgery at the Massachusetts General Hospital and used their archived, formalin-fixed, paraffin-embedded biopsy samples to create tissue microarrays (TMA). TMA sections were stained using antibodies against proteins in various DNA repair pathways including XPF, FANCD2, PAR, MLH1, PARP1, and phosphorylated MAPKAP kinase 2 (pMK2). Stained TMA slides were evaluated using machine-based image analysis, and scoring incorporated both the intensity and the quantity of positive tumor nuclei. Biomarker scores and clinical data were assessed for correlations with clinical outcome. Results: Higher scores for MLH1 (p = 0.018) and lower scores for FANCD2 (p = 0.037) were associated with pathologic response to neoadjuvant chemoradiation on multivariable analysis. Staining of MLH1, PARP1, XPF, and PAR was associated with recurrence-free survival, and staining of PARP1 and FANCD2 was associated with overall survival on multivariable analysis. Conclusions: DNA repair proteins analyzed by immunohistochemistry may be useful as predictive markers for response to neoadjuvant chemoradiotherapy in patients with esophageal cancer. These results are hypothesis generating and need confirmation in an independent data set.

  14. JAG Tearing Technique with Radiofrequency Guide Wire for Aortic Fenestration in Thoracic Endovascular Aneurysm Repair

    SciTech Connect (OSTI)

    Ricci, Carmelo [Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Radiologia Interventistica (Italy); Ceccherini, Claudio, E-mail: claudiocec@hotmail.it; Leonini, Sara [Radiologia Universitaria, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte (Italy); Cini, Marco; Vigni, Francesco [Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Radiologia Interventistica (Italy); Neri, Eugenio; Tucci, Enrico; Benvenuti, Antonio; Tommasino, Giulio; Sassi, Carlo [Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Chirurgia dell'Aorta Toracica (Italy)

    2012-02-15T23:59:59.000Z

    An innovative approach, the JAG tearing technique, was performed during thoracic endovascular aneurysm repair in a patient with previous surgical replacement of the ascending aorta with a residual uncomplicated type B aortic dissection who developed an aneurysm of the descending thoracic aorta with its lumen divided in two parts by an intimal flap. The proximal landing zone was suitable to place a thoracic stent graft. The distal landing zone was created by cutting the intimal flap in the distal third of the descending thoracic aorta with a radiofrequency guide wire and intravascular ultrasound catheter.

  15. Exposure Evaluation for Benzene, Lead and Noise in Vehicle and Equipment Repair Shops

    SciTech Connect (OSTI)

    Sweeney, Lynn C.

    2013-04-10T23:59:59.000Z

    An exposure assessment was performed at the equipment and vehicle maintenance repair shops operating at the U. S. Department of Energy Hanford site, in Richland, Washington. The maintenance shops repair and maintain vehicles and equipment used in support of the Hanford cleanup mission. There are three general mechanic shops and one auto body repair shop. The mechanics work on heavy equipment used in construction, cranes, commercial motor vehicles, passenger-type vehicles in addition to air compressors, generators, and farm equipment. Services include part fabrication, installation of equipment, repair and maintenance work in the engine compartment, and tire and brake services. Work performed at the auto body shop includes painting and surface preparation which involves applying body filler and sanding. 8-hour time-weighted-average samples were collected for benzene and noise exposure and task-based samples were collected for lead dust work activities involving painted metal surfaces. Benzene samples were obtained using 3M™ 3520 sampling badges and were analyzed for additional volatile organic compounds. These compounds were selected based on material safety data sheet information for the aerosol products used by the mechanics for each day of sampling. The compounds included acetone, ethyl ether, toluene, xylene, VM&P naphtha, methyl ethyl ketone, and trichloroethylene. Laboratory data for benzene, VM&P naphtha, methyl ethyl ketone and trichloroethylene were all below the reporting detection limit. Airborne concentrations for acetone, ethyl ether, toluene and xylene were all less than 10% of their occupational exposure limit. The task-based samples obtained for lead dusts were submitted for a metal scan analysis to identify other metals that might be present. Laboratory results for lead dusts were all below the reporting detection limit and airborne concentration for the other metals observed in the samples were less than 10% of the occupational exposure limit. Noise dosimetry sampling was performed on a random basis and was representative of the different work activities within the four shops. Twenty three percent of the noise samples exceeded the occupational exposure limit of 85 decibels for an 8-hour time-weightedaverage. Work activities where noise levels were higher included use of impact wrenches and grinding wheels.

  16. Endovascular Stent-Graft Repair as a Late Secondary Procedure After Previous Aortic Grafts

    SciTech Connect (OSTI)

    Matsagas, Miltiadis I. [School of Medicine, University of Ioannina, Department of Surgery - Vascular Surgery Unit (Greece)], E-mail: mimats@cc.uoi.gr; Anagnostopoulos, Constantine E. [School of Medicine, University of Ioannina, Department of Cardiothoracic Surgery (Greece); Papakostas, John C. [School of Medicine, University of Ioannina, Department of Surgery - Vascular Surgery Unit (Greece); DeRose, Joseph J. [St. Luke's-Roosevelt Hospital, Columbia University, Department of Cardiothoracic Surgery (United States); Siminelakis, Stavros [School of Medicine, University of Ioannina, Department of Cardiothoracic Surgery (Greece); Katsouras, Christos S. [School of Medicine, University of Ioannina, Department of Cardiology (Greece); Toumpoulis, Ioannis K.; Drossos, George E. [School of Medicine, University of Ioannina, Department of Cardiothoracic Surgery (Greece); Michalis, Lampros K. [School of Medicine, University of Ioannina, Department of Cardiology (Greece)

    2006-08-15T23:59:59.000Z

    Thoracic and abdominal aortic endovascular procedures as alternatives to aortic reoperations were studied in three different cases. An anastomotic aneurysm after previous thoracic aortic graft for coarctation, a second-stage elephant trunk repair (descending thoracic aortic aneurysm), and a secondary aneurysm proximal to a previous abdominal aortic graft were successfully treated with endovascular stent-grafts. During the follow-up period no lethal events or major aortic or graft-related complications were observed, except a type II endoleak in the anastomotic aortic aneurysm case. An endovascular stent-graft can be safely deployed into a previously implanted vascular graft, avoiding repeat surgery.

  17. Breaking News Export Control Certification on I-129 Required 21 Feb. 2011

    E-Print Network [OSTI]

    Scharer, John E.

    Breaking News Export Control Certification on I-129 Required 21 Feb. 2011 Effective 21 February-129 regarding compliance with the deemed export licensing requirements of the export control as the UW-Madison Export Control Officer, Tom Demke, to provide clear instructions and a form to ensure our

  18. NHMFL Breaks the 100 Tesla Barrier Gregory S. Boebinger, National High Magnetic Field Laboratory

    E-Print Network [OSTI]

    Weston, Ken

    NHMFL Breaks the 100 Tesla Barrier Gregory S. Boebinger, National High Magnetic Field Laboratory. 109no. 31 12404-12407 On March 22nd 2012, the NHMFL ­ Pulsed Field Facility broke the 100T tesla barrier, setting a world record of 100.75 tesla for a non-destructive magnet. By using advanced

  19. Facebook, Twitter and Google Plus for Breaking News: Is there a winner? Miles Osborne

    E-Print Network [OSTI]

    Osborne, Miles

    Facebook, Twitter and Google Plus for Breaking News: Is there a winner? Miles Osborne School Media have be- gun to carry news. Here we examine how Facebook, Google Plus and Twitter report Facebook or Google Plus. Face- book and Google Plus largely repost newswire stories and their main research

  20. All Your Face Are Belong to Us: Breaking Facebook's Social Authentication

    E-Print Network [OSTI]

    Yang, Junfeng

    All Your Face Are Belong to Us: Breaking Facebook's Social Authentication Iasonas Polakis FORTH adversaries from compromising accounts using stolen credentials. Facebook has recently released a two can obtain the information needed to solve the chal- lenges presented by Facebook. We implement

  1. Multiple Structural Breaks in India's GDP: Evidence from India's Service Sector

    E-Print Network [OSTI]

    Bandyopadhyay, Antar

    of economists and policy makers. India was designated as an agricultural country with a highest share1 Multiple Structural Breaks in India's GDP: Evidence from India's Service Sector Purba Roy Choudhury1 Abstract: This paper takes a comprehensive investigation into India's service sector, the main

  2. Assessing the catastrophic break up of Briksdalsbreen, Norway,1 associated with rapid climate change.2

    E-Print Network [OSTI]

    Southampton, University of

    about the potential influence of rapid climate change13 on the stability of major ice sheets retreat of Greenland's tidewater glaciers.32 33 Introduction34 The response of glaciers to climate change1 Assessing the catastrophic break up of Briksdalsbreen, Norway,1 associated with rapid climate

  3. Studying the Breaking Mechanism of Polymer-Based In-Situ Gelled Acids using Solid Breaker

    E-Print Network [OSTI]

    Tian, Zhida

    2012-10-19T23:59:59.000Z

    of this study is to examine the working mechanisms of the solid breaker and the factors that affect the breaking time. The flowback of the spent acid and the core damage induced by it will also be assessed in detail. Viscosity and rheological experimental...

  4. DISCOVER --Economic and societal benefit through research and collaboration The ground breaking motor

    E-Print Network [OSTI]

    Leeds, University of

    of fundamental problems facing policy makers ­ these include global warming, the impending energy crisis ­ whether globally in terms of products and services, or more locally and regionally in terms of employment breaking motor technology being commercialised by Magnomatics originated in the Department of Electrical

  5. Partial degeneracy breaking of the hydrogen energy spectrum from su_q(2)

    E-Print Network [OSTI]

    P. G. Castro; R. Kullock

    2012-12-07T23:59:59.000Z

    In this work we investigate the q-deformation of the so(4) dynamical symmetry of the hydrogen atom using the theory of the quantum group su_q(2), and construct the discrete part of the energy spectrum. This will lead to a partial breaking of the degeneracy of the energy levels and to a reduction of the Hilbert space.

  6. Under consideration for publication in J. Fluid Mech. 1 Dam breaking seiches

    E-Print Network [OSTI]

    Balmforth, Neil

    hazards should the dam break suddenly. Indeed, geological evidence points to a number of recent failures & Evans 2000). One of the principal causes of moraine dam failure is claimed to be catastrophic erosional et al. 2002; Cao et al. 2004). By contrast, the failure of a moraine-dammed lake has never been

  7. Modular Invariant Soft Breaking, WMAP, Dark Matter and Sparticle Mass Limits

    E-Print Network [OSTI]

    Chattopadhyay, Utpal; Chattopadhyay, Utpal; Nath, Pran

    2004-01-01T23:59:59.000Z

    An analysis of soft breaking under the constraint of modular invariance is given. The role of dilaton and moduli dependent front factors in achieving a modular invariant $V_{soft}$ is emphasized. Further, it is shown that in string models $\\tan\\beta$ is no longer a free parameter but is determined in terms of $\\alpha_{string}$ and the other soft parameters by the constraints of modular invariance and radiative electroweak symmetry breaking. The above framework is then used to analyze the neutralino relic density consistent with the WMAP data at self dual points in the Kahler and complex structure moduli. One finds that the combined set of constraints arising from modular invariant soft breaking, radiative electroweak symmetry breaking and WMAP lead to upper limits on sparticle masses for $\\mu>0$. These limits are investigated for a class of models and found to lie within reach of the Tevatron and of the Large Hadron Collider (LHC). Further, an analysis of the neutralino-proton cross section shows that dark ma...

  8. Total Break of the -IC Signature Scheme Pierre-Alain Fouque1

    E-Print Network [OSTI]

    Fouque, Pierre-Alain

    - analysis of multivariate schemes and have lead to the efficient break of SFLASH in practice. In this work- signature scheme recently proposed at PKC 2007. This cryptosystem is a multivariate scheme based on a new internal quadratic primitive which avoids some drawbacks of previous multivari- ate schemes: the scheme

  9. Breaking POET Authentication with a Single Query Jian Guo, Jeremy Jean, Thomas Peyrin, and Lei Wang

    E-Print Network [OSTI]

    Breaking POET Authentication with a Single Query Jian Guo, J´er´emy Jean, Thomas Peyrin, and Lei article, we describe a very practical and simple attack on the au- thentication part of POET authenticated encryption mode proposed at FSE 2014. POET is a provably secure scheme that was designed to resist various

  10. Instability of two-dimensional graphene: Breaking sp2 bonds with soft x rays

    E-Print Network [OSTI]

    Zettl, Alex

    Instability of two-dimensional graphene: Breaking sp2 bonds with soft x rays S. Y. Zhou,1,2 Ç. Ö the stability of various kinds of graphene samples under soft x-ray irradiation. Our results show that in single-layer exfoliated graphene a closer analog to two-dimensional material , the in-plane carbon- carbon bonds

  11. The University of New Hampshire in 2020: Breaking Silos, Transforming Lives, Reimagining the University

    E-Print Network [OSTI]

    their historic mission and respond energetically and effectively to these new challenges? The University of New1 The University of New Hampshire in 2020: Breaking Silos, Transforming Lives, Reimagining of our state, our nation and our world. For 143 years we have served the people and communities of New

  12. Role of Symmetry Breaking on the Optical Transitions in Lead-Salt Quantum Dots

    E-Print Network [OSTI]

    Van Stryland, Eric

    Role of Symmetry Breaking on the Optical Transitions in Lead-Salt Quantum Dots Gero Nootz to explain optical transitions in lead-salt QDs. Thus, while the band anisotropy of the bulk semiconductor functions. These studies clarify the controversy of the origin of spectral features in lead-salt QDs

  13. Winery waste makes fuel Electricity, bacteria break organics in wastewater into hydrogen gas

    E-Print Network [OSTI]

    from agricultural wastes." Napa Wine Company's wastewater comes from grape disposal, wine makingMSNBC.com Winery waste makes fuel Electricity, bacteria break organics in wastewater into hydrogen method for generating hydrogen fuel from wastewater is now operating at a California winery

  14. Constituent Particle Break-up during Hot Rolling of AA 5182 Nicolas Moulin(1)

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Constituent Particle Break-up during Hot Rolling of AA 5182 Nicolas Moulin(1) , Estelle Parra hot reversible rolling of AA5182 alloy sheets has been analysed. The sizes and shapes of intermetallic particles in as-cast and industrially hot rolled AA5182 alloys sheets were characterized by 3D X ray

  15. WHEN GLACIERS BREAK THE ICE BETWEEN SEVERAL SCIENTIFIC HORIZONS T. Landes, P. Grussenmeyer, M. Koehl

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    WHEN GLACIERS BREAK THE ICE BETWEEN SEVERAL SCIENTIFIC HORIZONS T. Landes, P. Grussenmeyer, M temperate glacier activity. For this ambitious purpose, it was necessary to reassemble specialists coming glaciers was a unique opportunity for the MAP-PAGE team, specialized in geodetic surveying and imaging

  16. MEASUREMENTS OF SHALLOW WATER BREAKING WAVE ROLLERS Merrick C. Haller and Patricio Cataln

    E-Print Network [OSTI]

    Haller, Merrick

    . Since there is a lack of shallow water roller measurements, investigators have instead used the waveMEASUREMENTS OF SHALLOW WATER BREAKING WAVE ROLLERS Merrick C. Haller and Patricio Catalán 1 Ocean water and wave roller transformation in the surf zone. The approach is new in the sense

  17. GRB Jet Breaks and Energetics in the Swift/Chandra era

    E-Print Network [OSTI]

    ?umer, Slobodan

    GRB Jet Breaks and Energetics in the Swift/Chandra era Prof. David Burrows The Pennsylvania State University #12;Outline n Broad overview of GRB progress since 1960's n GRB jet physics n Swift satellite n X-ray light curves of GRBs n New relativistic hydrodynamical models for GRB jets n Preliminary

  18. Remote bond breaking by interacting temporary anion states P. D. Burrowa

    E-Print Network [OSTI]

    Simons, Jack

    Remote bond breaking by interacting temporary anion states P. D. Burrowa and G. A. Gallupb negative ion state elsewhere in the molecule, even one quite remote from the first. In a series place at a site that is remote from the location of the original resonance is the topic of this present

  19. Chiral symmetry breaking in the truncated Coulomb gauge: Nonconfining power law potentials

    SciTech Connect (OSTI)

    Bicudo, P. [CFTP, Departamento de Fisica, Instituto Superior Tecnico, Av. Rovisco Pais, 1049-001 Lisboa (Portugal)

    2009-05-01T23:59:59.000Z

    In this paper we study the breaking of chiral symmetry with nonconfining powerlike potentials. The region of allowed exponents is identified and, after the previous study of confining (positive exponent) potentials, we now specialize in shorter range nonconfining potentials, with a negative exponent. These nonconfining potentials are close to the Coulomb potential, and they are also relevant as corrections to the linear confinement, and as models for the quark potential at the deconfinement transition. The mass-gap equation is constructed and solved, and the quark mass, the chiral angle, and the quark energy are calculated analytically with an exponent expansion in the neighborhood of the Coulomb potential. It is demonstrated that chiral symmetry breaking occurs, but only the chiral invariant false vacuum and a second nontrivial vacuum exist. Moreover chiral symmetry breaking is led by the ultraviolet part of the potential, with no infrared enhancement of the quark mass. Thus the breaking of chiral symmetry driven by nonconfining potentials differs from the one lead by confining potentials.

  20. 2014-2015 Trip Information Fall Break: October 22-25, 2014

    E-Print Network [OSTI]

    Almor, Amit

    Click Here Poverty & Elderly; Christmas in Action; Spartanburg, SC Trip Leader: Tina Mauer Christmas disadvantaged homeowners. For more information Click Here Poverty & Homelessness; Habitat for Humanity; John Click Here Spring Break: March 7-14, 2015 Hunger & Poverty; C.R.O.S. Ministries; West Palm Beach, FL

  1. XXII ICTAM, 2529 August 2008, Adelaide, Australia SPACE-TIME MEASUREMENTS OF BREAKING WAVE KINEMATICS

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    with light intensity. WAVE KINEMATICS Phase average vorticity In order to have a statistical evolutionXXII ICTAM, 25­29 August 2008, Adelaide, Australia SPACE-TIME MEASUREMENTS OF BREAKING WAVE KINEMATICS AND VOID FRACTION IN THE SURF ZONE Olivier Kimmoun1 , 2 Hubert Branger1 1IRPHE, CNRS, Aix

  2. Spontaneous breaking of translational invariance in noncommutative {lambda}{phi}{sup 4} theory in two dimensions

    SciTech Connect (OSTI)

    Castorina, P.; Zappala, D. [Department of Physics, University of Catania and INFN Sezione di Catania, Via S. Sofia 64, I 95123, Catania (Italy); INFN Sezione di Catania, Via S. Sofia 64, I 95123, Catania (Italy)

    2008-01-15T23:59:59.000Z

    The spontaneous breaking of translational invariance in noncommutative self-interacting scalar field theory in two dimensions is investigated by effective action techniques. The analysis confirms the existence of the stripe phase, already observed in lattice simulations, due to the nonlocal nature of the noncommutative dynamics.

  3. Numerical Simulation of Breaking Waves Using Level-Set Navier-Stokes Method

    E-Print Network [OSTI]

    Dong, Qian

    2010-07-14T23:59:59.000Z

    ) equations were employed for the prediction of nonlinear wave-interaction and wave-breaking phenomena over sloping beaches. In the level-set finite-analytic Navier-Stokes (FANS) method, the free surface is represented by the zero level-set function...

  4. Pseudo-magnetic catalysis of the time-reversal symmetry breaking in graphene

    E-Print Network [OSTI]

    Igor F. Herbut

    2008-11-25T23:59:59.000Z

    Finite flux of the (time-reversal-symmetric) pseudo-magnetic field, which represents the effect of wrinkling of the graphene sheet for example, is shown to be a catalyst for spontaneous breaking of the time-reversal symmetry of Dirac fermions in two dimensions. Possible experimental consequences of this effect for graphene are discussed.

  5. Role of global warming on the statistics of record-breaking temperatures S. Redner1,

    E-Print Network [OSTI]

    Redner, Sidney

    Role of global warming on the statistics of record-breaking temperatures S. Redner1, * and Mark R in Philadelphia, as a function of the number of years of observation. We then consider the case of global warming question arises: is global warming the cause of such heat waves or are they merely statistical fluctuations

  6. Hydrogen Bond Networks: Structure and Evolution after Hydrogen Bond Breaking John B. Asbury, Tobias Steinel, and M. D. Fayer*

    E-Print Network [OSTI]

    Fayer, Michael D.

    Hydrogen Bond Networks: Structure and Evolution after Hydrogen Bond Breaking John B. Asbury, TobiasVed: September 1, 2003; In Final Form: December 18, 2003 The nature of hydrogen bonding networks following hydrogen bond breaking is investigated using vibrational echo correlation spectroscopy of the hydroxyl

  7. Ambiguities of the CPT-even aether-like Lorentz-breaking term at the finite temperature

    E-Print Network [OSTI]

    T. Mariz; J. R. Nascimento; A. Yu. Petrov; W. Serafim

    2014-06-11T23:59:59.000Z

    In this paper, we consider the finite temperature behaviour of the CPT-even aether-like Lorentz-breaking term in the extended Lorentz-breaking QED and demonstrate that its ambiguities whose presence has been shown earlier in the zero temperature case stay also at the finite temperature.

  8. Dofasco`s No. 4 blast furnace hearth breakout, repair and rescue

    SciTech Connect (OSTI)

    Donaldson, R.J.; Fischer, A.J.; Sharp, R.M.; Stothart, D.W. [Dofasco Inc., Hamilton, Ontario (Canada)

    1995-12-01T23:59:59.000Z

    On May 5, 1994, after producing 9.5 million metric tons of iron, Dofasco`s No. 4 Blast Furnace experienced a hearth breakout 250 millimeters below the west taphole. The hot metal spill caused a fire resulting in severe damage and 33 days of lost production. During a 26-day period, electrical wiring, water drainage systems and both tapholes were repaired. Recovery from an unprepared furnace stop of this length, with the deadman depleted is difficult. To aid with the rescue Hoogovens-designed oxygen/fuel lances were commissioned. The furnace recovery began with a lance in each taphole and all tuyeres plugged. Six days after startup the furnace was casting into torpedo cars, and after nine days operation had returned to normal. This incident prompted Dofasco to expand the hearth monitoring system to detect and prevent similar occurrences. During the repair, 203 new thermocouples were installed in the hearth, concentrating on the tapholes and elephant foot areas. These thermocouples were installed at various depths and locations to allow heat flux calculations. This hearth monitoring system has already identified other problem areas and provided valuable information about hearth drainage patterns. This information has allowed them to develop control strategies to manage localized problem areas.

  9. Percutaneous Stent-Graft Repair of a Mycotic Pulmonary Artery Pseudoaneurysm

    SciTech Connect (OSTI)

    Chou Meichun; Liang Hueilung, E-mail: hlliang@isca.vghks.gov.tw; Pan Huayban; Yang Chienfang [Kaohsiung Veterans General Hospital, Department of Radiology (China)

    2006-10-15T23:59:59.000Z

    Ruptured mycotic pulmonary pseudoaneurysm is a lethal complication. Emergent surgical repair is usually recommended, but still associated with a high mortality rate. We present a patient in whom mycotic pulmonary pseudoaneurysm was a complication after surgical lobectomy 2 weeks earlier. This patient had suffered from repeated massive hemoptysis. After emergent surgical repair of the ruptured pulmonary artery stump, another episode of massive hemorrhage occurred. The pulmonary arteriogram revealed a segmental stenosis and a large, wide-necked, lobulated pseudoaneurysm at the left proximal pulmonary artery. We deployed a balloon-expandable stent-graft (48 mm in length mounted on a 12 mm x 40 mm angioplasty balloon) across the stenotic segment and the neck of the pulmonary pseudoaneurysm. Hemostasis was achieved immediately and, under a 4-week antibiotic treatment, patient was transferred to a local hospital for medical care. This case report demonstrates the benefit of minimally invasive endovascular therapy in a critically ill patient. A literature review of the etiology and management of mycotic pulmonary pseudoaneurysm is included.

  10. Molecular Imaging of the ATM Kinase Activity

    SciTech Connect (OSTI)

    Williams, Terence M. [Department of Radiation Oncology, Ohio State University, Columbus, Ohio (United States); Nyati, Shyam [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Ross, Brian D. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Rehemtulla, Alnawaz, E-mail: alnawaz@umich.edu [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)

    2013-08-01T23:59:59.000Z

    Purpose: Ataxia telangiectasia mutated (ATM) is a serine/threonine kinase critical to the cellular DNA-damage response, including from DNA double-strand breaks. ATM activation results in the initiation of a complex cascade of events including DNA damage repair, cell cycle checkpoint control, and survival. We sought to create a bioluminescent reporter that dynamically and noninvasively measures ATM kinase activity in living cells and subjects. Methods and Materials: Using the split luciferase technology, we constructed a hybrid cDNA, ATM-reporter (ATMR), coding for a protein that quantitatively reports on changes in ATM kinase activity through changes in bioluminescence. Results: Treatment of ATMR-expressing cells with ATM inhibitors resulted in a dose-dependent increase in bioluminescence activity. In contrast, induction of ATM kinase activity upon irradiation resulted in a decrease in reporter activity that correlated with ATM and Chk2 activation by immunoblotting in a time-dependent fashion. Nuclear targeting improved ATMR sensitivity to both ATM inhibitors and radiation, whereas a mutant ATMR (lacking the target phosphorylation site) displayed a muted response. Treatment with ATM inhibitors and small interfering (si)RNA-targeted knockdown of ATM confirm the specificity of the reporter. Using reporter expressing xenografted tumors demonstrated the ability of ATMR to report in ATM activity in mouse models that correlated in a time-dependent fashion with changes in Chk2 activity. Conclusions: We describe the development and validation of a novel, specific, noninvasive bioluminescent reporter that enables monitoring of ATM activity in real time, in vitro and in vivo. Potential applications of this reporter include the identification and development of novel ATM inhibitors or ATM-interacting partners through high-throughput screens and in vivo pharmacokinetic/pharmacodynamic studies of ATM inhibitors in preclinical models.

  11. Operational results of shaft repair by installing stave type cooler at Kimitsu Nos. 3 and 4 blast furnaces

    SciTech Connect (OSTI)

    Oda, Hiroshi; Amano, Shigeru; Sakamoto, Aiichiro; Anzai, Osamu [Nippon Steel Corp., Kimitsu, Chiba (Japan). Kimitsu Works; Nakagome, Michiru; Kuze, Toshisuke [Nippon Steel Corp., Futtsu, Chiba (Japan); Imuta, Akira [Nippon Steel Corp., Tokyo (Japan). Plant and Machinery Div.

    1997-12-31T23:59:59.000Z

    Nos. 3 and 4 blast furnaces in Nippon Steel Corporation Kimitsu Works were both initially fitted with cooling plate systems. With the aging of each furnace, the damage to their respective inner-shaft profiles had become serious. Thus, in order to prevent operational change and prolong the furnace life, the inner-shaft profile of each furnace was repaired by replacing the former cooling plate system with the stave type cooler during the two-week-shutdowns. With this repair, stability of burden descent and gas flow near the wall part of the furnace have been achieved. Thus the prolongation of the furnace life is naturally expected.

  12. Inhibition of X-ray-induced potentially lethal damage (PLD) repair in aerobic plateau-phase Chinese hamster cells by misonidazole

    SciTech Connect (OSTI)

    Brown, D.M.

    1984-01-01T23:59:59.000Z

    The effect of the 2-nitroimidazole radiosensitizer misonidazole (MISO) and the hydrophilic analog SR-2508 on the repair of X-ray-induced potentially lethal damage (PLD) was studied in plateau-phase Chinese Hamster ovary (HA-1) cells. It was found that although MISO does not radiosensitize aerobic cells, it inhibits the repair of PLD. However, under hypoxic conditions, MISO has no effect on PLD repair. The major portion of the inhibition of PLD repair in aerobic cells requires the presence of MISO only during irradiation; little or no additional inhibition occurs when MISO is present during the postirradiation repair period. Also, treatment of aerobic cells with 5 mM MISO for either 5 or 30 min prior to irradiation is equally inhibitory. This suggests that the presence of MISO in some way modifies the initial lesion under aerobic conditions since it does not increase cell killing as determined by immediate plating but inhibits subsequent repair. The inhibition is concentration dependent; 0.5 mM MISO inhibits PLD repair by one-half while 5-10 mM totally inhibits the repair measured 6 hr postirradiation. This phenomenon suggests that radiosensitization of tissue in vivo by MISO and other 2-nitroimidazoles may not be unequivocal proof of the presence of hypoxic cells.

  13. Subj: Educational and General (E&G) Facility Support Provide an overview of Facility Operations, Maintenance, Repair and Renovation and Space

    E-Print Network [OSTI]

    support, and, preventive and unscheduled maintenance of all building systems, with the exception of BAS Operations, Maintenance, Repair and Renovation and Space Management Procedures and Practices. KEY DEFINITIONS chambers, fume hoods, fixed seating, etc. are normally considered part of the building. Maintenance, repair

  14. Performance and Impact from Duct Repair and Ventilation Modifications of Two Newly Constructed Manufactured Houses Located in a Hot and Humid Climate

    E-Print Network [OSTI]

    Withers, C.; Moyer, N.; Chasar, D.; Chandra, S.

    2002-01-01T23:59:59.000Z

    airtightness was adjusted until it was the same in each house, and duct leaks were sealed so that the ducts were tight and there was equal tightness in both houses. A ventilation system was also added at the same time of duct repair. Duct repair...

  15. Original Full Length Article Inkjet-based biopatterning of SDF-1 augments BMP-2-induced repair of

    E-Print Network [OSTI]

    Weiss, Lee E.

    Original Full Length Article Inkjet-based biopatterning of SDF-1 augments BMP-2-induced repair Biopatterning BMP-2 SDF-1 TGF-1 Background: A major problem in craniofacial surgery is non-healing bone defects-derived factor-1 (SDF-1), transforming growth factor-1 (TGF-1), or co-therapies thereof. We tested the hypothesis

  16. The Effect of Debris on Collector Optics, its Mitigation and Repair: Next-Step a Gaseous Sn EUV DPP Source

    E-Print Network [OSTI]

    Spila, Timothy P.

    The Effect of Debris on Collector Optics, its Mitigation and Repair: Next-Step a Gaseous Sn EUV DPP to advanced fuel plasma EUV sources is collector lifetime. The Illinois Debris-mitigation EUV Applications based on this work. Keywords: EUV source, debris, optics, collector lifetime, mitigation, plasma

  17. Image-Guided Techniques Improve the Short-term Outcome of Autologous Osteochondral Cartilage Repair Surgeries -An

    E-Print Network [OSTI]

    Stewart, James

    Image-Guided Techniques Improve the Short-term Outcome of Autologous Osteochondral Cartilage Repair and deliver osteochondral grafts remains problematic. We investigated whether image-guided methods (optically-guided and template-guided) can improve the outcome of mo- saic arthroplasty procedures. Methods: Fifteen sheep were

  18. Surgical technique, using skin, for repair of simultaneously ruptured anterior cruciate and medial collateral ligaments of the canine femorotibial articulation

    E-Print Network [OSTI]

    Chastain, Jamie Neal

    1959-01-01T23:59:59.000Z

    Agricultural and Mechanical College of Texan In Partial Fulfillnent of the !Iequireaents for the Degree Meeter of Science in Veterinary Medicine and Surgery by Janie Neal Chaetain January 1&359 SURGICAL TECHNI((UE ~ USIN'G SKIN ~ FOR REPAIR...

  19. Diet-dependent survival of protein repair-deficient miceB Christine E. Farrar, Steven ClarkeT

    E-Print Network [OSTI]

    Clarke, Steven

    Diet-dependent survival of protein repair-deficient miceB Christine E. Farrar, Steven Clarke, and mice lacking this enzyme accumulate damaged proteins in multiple tissues, die at an early age from and in vivo [1­7]. Mice lacking the enzyme (Pcmt1Ŕ/Ŕ mice) accu- mulate damaged proteins in multiple tissues

  20. A review of "To Repair the Ruins: Reading Milton" edited by Mary C. Fenton and Louis Schwartz

    E-Print Network [OSTI]

    Welch, Anthony

    2013-01-01T23:59:59.000Z

    that deserve the attention he gives them. Mary C. Fenton and Louis Schwartz, eds. To Repair the Ruins: Reading Milton. Pittsburgh: Duquesne University Press, #18;#17;#16;#18;. xii + #1;#30; pp. + #18;#18; illus. $#14;#15;.#17;#17;. Review by #8...

  1. Radial Dependence of the Frequency Break Between Fluid and Kinetic Scales in the Solar Wind Fluctuations

    E-Print Network [OSTI]

    Bruno, R

    2014-01-01T23:59:59.000Z

    We investigate the radial dependence of the spectral break separating the inertial from the dissipation range in power density spectra of interplanetary magnetic field fluctuations, between $0.42$ and $5.3$ AU, during radial alignments between MESSENGER and WIND for the inner heliosphere and between WIND and ULYSSES for the outer heliosphere. We found that the spectral break moves to higher and higher frequencies as the heliocentric distance decreases. The radial dependence of the corresponding wavenumber is of the kind $\\kappa_b\\sim R^{-1.08}$ in good agreement with that of the wavenumber derived from the linear resonance condition for proton cyclotron damping. These results support conclusions from previous studies which suggest that a cyclotron-resonant dissipation mechanism must participate into the spectral cascade together with other possible kinetic noncyclotron-resonant mechanisms.

  2. Breaking of relativistically intense longitudinal space charge waves: A description using Dawson sheet model

    SciTech Connect (OSTI)

    Sengupta, Sudip, E-mail: sudip@ipr.res.in [Institute for Plasma Research, Bhat , Gandhinagar - 382428 (India)

    2014-02-11T23:59:59.000Z

    Spatio-temporal evolution of relativistically intense longitudinal space charge waves in a cold homogeneous plasma is studied analytically as well as numerically, as an initial value problem, using Dawson sheet model. It is found that, except for very special initial conditions which generates the well known longitudinal Akhiezer-Polovin mode, for all other initial conditions, the waves break through a novel mechanism called phase mixing at an amplitude well below the Akhiezer-Polovin limit. An immediate consequence of this is, that Akhiezer-Polovin waves break when subjected to arbitrarily small longitudinal perturbations. We demonstrate this by performing extensive numerical simulations. This result may be of direct relevance to ultrashort, ultraintense laser/beam pulse-plasma interaction experiments where relativistically intense waves are routinely excited.

  3. Quantitative similarity analysis of small-break loss-of-coolant accident scenarios

    SciTech Connect (OSTI)

    Prosek, A.; Kljenak, I.; Mavko, B. [Univ. of Ljubljana (Slovenia). Jozef Stefan Inst.

    1996-07-01T23:59:59.000Z

    Classifications of small-break loss-of-coolant accidents based on objective quantitative similarity analysis are proposed. Accident scenarios were simulated in a two-loop pressurized water reactor plant with the RELAP5/MOD3.1 computer code for break sizes ranging from 1.27 cm (0.5 in.) to 15.2 cm (6 in.), with different availability of auxiliary feedwater system or reactor coolant pump trip delay. Similarities between different accident simulations were evaluated by comparing relevant time-dependent parameters with fast Fourier transform and correlation methods. Quantification of similarity between accident simulations could eventually lead to further development of the Code Scaling, Applicability and Uncertainty methodology.

  4. Inversion symmetry breaking of atomic bound states in strong and short laser fields

    E-Print Network [OSTI]

    Stooß, Veit; Ott, Christian; Blättermann, Alexander; Ding, Thomas; Pfeifer, Thomas

    2015-01-01T23:59:59.000Z

    In any atomic species, the spherically symmetric potential originating from the charged nucleus results in fundamental symmetry properties governing the structure of atomic states and transition rules between them. If atoms are exposed to external electric fields, these properties are modified giving rise to energy shifts such as the AC Stark-effect in varying fields and, contrary to this in a constant (DC) electric field for high enough field strengths, the breaking of the atomic symmetry which causes fundamental changes in the atom's properties. This has already been observed for atomic Rydberg states with high principal quantum numbers. Here, we report on the observation of symmetry breaking effects in Helium atoms for states with principal quantum number n=2 utilizing strong visible laser fields. These findings were enabled by temporally resolving the dynamics better than the sub-optical cycle of the applied laser field, utilizing the method of attosecond transient absorption spectroscopy (ATAS). We ident...

  5. Vacuum Bellows, Vacuum Piping, Cryogenic Break, and Copper Joint Failure Rate Estimates for ITER Design Use

    SciTech Connect (OSTI)

    L. C. Cadwallader

    2010-06-01T23:59:59.000Z

    The ITER international project design teams are working to produce an engineering design in preparation for construction of the International Thermonuclear Experimental Reactor (ITER) tokamak. During the course of this work, questions have arisen in regard to safety barriers and equipment reliability as important facets of system design. The vacuum system designers have asked several questions about the reliability of vacuum bellows and vacuum piping. The vessel design team has asked about the reliability of electrical breaks and copper-copper joints used in cryogenic piping. Research into operating experiences of similar equipment has been performed to determine representative failure rates for these components. The following chapters give the research results and the findings for vacuum system bellows, power plant stainless steel piping (amended to represent vacuum system piping), cryogenic system electrical insulating breaks, and copper joints.

  6. Study of charge symmetry breaking in dd collisions with WASA-at-COSY

    SciTech Connect (OSTI)

    Wronska, Aleksandra [Institute of Physics, Jagiellonian University, Cracow, Reymonta 4, 30-059 Cracow (Poland)

    2011-10-24T23:59:59.000Z

    Charge symmetry is an approximate symmetry of the strong interaction. Studies of its breaking can yield information on the u and d quark mass difference. A theoretical collaboration is currently working on the description of charge symmetry breaking mechanisms for dd{yields}{alpha}{pi}{sup 0} and np{yields}d{pi}{sup 0} within Chiral Perturbation Theory, using the data from TRI-UMF and IUCF. One of the items in the program of the WASA-at-COSY collaboration is to extend the data base for the dd{yields}{alpha}{pi}{sup 0} reaction to higher energies, which would allow the extraction of the information on the p-wave. Status of the analysis of experimental data along with the preliminary results from the pilot run will be presented here.

  7. A Free Energy Landscape for Cage Breaking of Three Hard Disks

    E-Print Network [OSTI]

    Gary L. Hunter; Eric R. Weeks

    2011-12-21T23:59:59.000Z

    We investigate cage breaking in dense hard disk systems using a model of three Brownian disks confined within a circular corral. This system has a six-dimensional configuration space, but can be equivalently thought to explore a symmetric one-dimensional free energy landscape containing two energy minima separated by an energy barrier. The exact free energy landscape can be calculated as a function of system size. Results of simulations show the average time between cage breaking events follows an Arrhenius scaling when the energy barrier is large. We also discuss some of the consequences of using a one-dimensional representation to understand dynamics in a multi-dimensional space, such as diffusion acquiring spatial dependence and discontinuities in spatial derivatives of free energy.

  8. Effective Field Theory of Emergent Symmetry Breaking in Deformed Atomic Nuclei

    E-Print Network [OSTI]

    T. Papenbrock; H. A. Weidenmüller

    2015-05-07T23:59:59.000Z

    Spontaneous symmetry breaking in non-relativistic quantum systems has previously been addressed in the framework of effective field theory. Low-lying excitations are constructed from Nambu-Goldstone modes using symmetry arguments only. We extend that approach to finite systems. The approach is very general. To be specific, however, we consider atomic nuclei with intrinsically deformed ground states. The emergent symmetry breaking in such systems requires the introduction of additional degrees of freedom on top of the Nambu-Goldstone modes. Symmetry arguments suffice to construct the low-lying states of the system. In deformed nuclei these are vibrational modes each of which serves as band head of a rotational band.

  9. Design structure for in-system redundant array repair in integrated circuits

    DOE Patents [OSTI]

    Bright, Arthur A.; Crumley, Paul G.; Dombrowa, Marc; Douskey, Steven M.; Haring, Rudolf A.; Oakland, Steven F.; Quellette, Michael R.; Strissel, Scott A.

    2008-11-25T23:59:59.000Z

    A design structure for repairing an integrated circuit during operation of the integrated circuit. The integrated circuit comprising of a multitude of memory arrays and a fuse box holding control data for controlling redundancy logic of the arrays. The design structure provides the integrated circuit with a control data selector for passing the control data from the fuse box to the memory arrays; providing a source of alternate control data, external of the integrated circuit; and connecting the source of alternate control data to the control data selector. The design structure further passes the alternate control data from the source thereof, through the control data selector and to the memory arrays to control the redundancy logic of the memory arrays.

  10. Designer's guidebook for first wall/blanket/shield assembly, maintenance, and repair

    SciTech Connect (OSTI)

    Not Available

    1983-12-30T23:59:59.000Z

    This is the initial issue of the guidebook. Since a guidebook of this type must incorporate information concerning a wide range of subjects, much additional data will eventually be included. The guidebook will document, in summary and easily referenceable form, data, designs, design concepts, design guidelines and background information useful to the FWBS and to the Maintenance System designer. In providing guidelines for the AMR of the FWBS, the guidebook must, of necessity, include guidelines for all aspects of maintenance associated with the FWBS. These include most maintenance operations within the reactor room necessary to gain access, identify faults, and handle equipment related to FWBS maintenance. In addition, the guidelines include those required to define facility requirements for handling and repair of FWBS and related reactor components external to the reactor room. Particular emphasis is given to remote maintenance design and operations.

  11. On the breaking and restoration of symmetries within the nuclear energy density functional formalism

    E-Print Network [OSTI]

    T. Duguet; J. Sadoudi

    2010-10-19T23:59:59.000Z

    We review the notion of symmetry breaking and restoration within the frame of nuclear energy density functional methods. We focus on key differences between wave-function- and energy-functional-based methods. In particular, we point to difficulties encountered within the energy functional framework and discuss new potential constraints on the underlying energy density functional that could make the restoration of broken symmetries better formulated within such a formalism. We refer to Ref.~\\cite{duguet10a} for details.

  12. Simulation of a small break loss of coolant accident conducted at the BETHSY Integral Test Facility

    E-Print Network [OSTI]

    Bott, Charles Patrick

    1992-01-01T23:59:59.000Z

    of the requirements for the degree ol' MASTER OF SCIENCE May 1992 Major Subject: Nuclear Engineering SIMULATION OF A SMALL BREAK LOSS OF COOLANT ACCIDENT CONDUCTED AT THE BETHSY INTEGRAL TEST FACILITY A Thesis by CHARLES PATRICK BOTT Approved as to style.... ACKNOWLEDGEMENT I would like to thank Dr. Yassin Hassan. my advisor and committee chair, for his support and direction for this project. I am indebted to the Idaho National Engineenng Lab's RELAP support group for their code troubleshooting as well...

  13. Loss of feed flow, steam generator tube rupture and steam line break thermohydraulic experiments

    SciTech Connect (OSTI)

    Mendler, O J; Takeuchi, K; Young, M Y

    1986-10-01T23:59:59.000Z

    The Westinghouse Model Boiler No. 2 (MB-2) steam generator test model at the Engineering Test Facility in Tampa, Florida, was reinstrumented and modified for performing a series of tests simulating steam generator accident transients. The transients simulated were: loss of feed flow, steam generator tube rupture, and steam line break events. This document presents a description of (1) the model boiler and the associated test facility, (2) the tests performed, and (3) the analyses of the test results.

  14. Lorentz symmetry breaking in the noncommutative Wess-Zumino model: One loop corrections

    SciTech Connect (OSTI)

    Ferrari, A.F.; Gomes, M.; Girotti, H.O. [Instituto de Fisica, Universidade de Sao Paulo, Caixa Postal 66318, 05315-970, Sao Paulo - SP (Brazil); Instituto de Fisica, Universidade Federal do Rio Grande do Sul, Caixa Postal 15051, 91501-970 - Porto Alegre, RS (Brazil)

    2006-02-15T23:59:59.000Z

    In this paper we deal with the issue of Lorentz symmetry breaking in quantum field theories formulated in a noncommutative space-time. We show that, unlike in some recent analysis of quantum gravity effects, supersymmetry does not protect the theory from the large Lorentz-violating effects arising from the loop corrections. We take advantage of the noncommutative Wess-Zumino model to illustrate this point.

  15. Isospin symmetry breaking and baryon-isospin correlations from Polyakov$-$Nambu$-$Jona-Lasinio model

    E-Print Network [OSTI]

    Abhijit Bhattacharyya; Sanjay K. Ghosh; Anirban Lahiri; Sarbani Majumder; Sibaji Raha; Rajarshi Ray

    2014-06-11T23:59:59.000Z

    We present a study of the 1+1 flavor system of strongly interacting matter in terms of the Polyakov$-$Nambu$-$Jona-Lasinio model. We find that though the small isospin symmetry breaking brought in through unequal light quark masses is too small to affect the thermodynamics of the system in general, it may have significant effect in baryon-isospin correlations and have a measurable impact in heavy-ion collision experiments.

  16. Record-breaking year for patents | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection RadiationRecord-Setting Microscopy Illuminates EnergyRecord-breaking

  17. New Supersoft Supersymmetry Breaking Operators and a Solution to the $?$ Problem

    E-Print Network [OSTI]

    Ann E. Nelson; Tuhin S. Roy

    2015-01-20T23:59:59.000Z

    We propose the framework, "generalized supersoft supersymmetry breaking". "Supersoft" models, with $D$-type supersymmetry breaking and heavy Dirac gauginos, are considerably less constrained by the LHC searches than the well studied MSSM. These models also ameliorate the supersymmetric flavor and $CP$ problems. However, previously considered mechanisms for obtaining a natural size Higgsino mass parameter (namely, $\\mu$) in supersoft models have been relatively complicated and contrived. Obtaining a $125\\gev$ for the mass of the lightest Higgs boson has also been difficult. Additional issues with the supersoft scenario arise from the fact that these models contain new scalars in the adjoint representation of the standard model, which may obtain negative squared-masses, breaking color and generating too large a $T$-parameter. In this work we introduce new operators into supersoft models which can potentially solve all these issues. A novel feature of this framework is that the new $\\mu$-term can give unequal masses to the up and down type Higgs fields, and the Higgsinos can be much heavier than the Higgs boson without fine-tuning. However, unequal Higgs and Higgsino masses can also destroy some attractive features of supersoft susy.

  18. Light scalar as the messenger of electroweak and flavor symmetry breaking

    SciTech Connect (OSTI)

    Lykken, J. D. [Theoretical Physics Department, Fermilab, P.O. Box 500, Batavia, Illinois 60510 (United States); Murdock, Z. [Department of Physics and Oklahoma Center for High Energy Physics, Oklahoma State University, Stillwater, Oklahoma 74078 (United States); Nandi, S. [Theoretical Physics Department, Fermilab, P.O. Box 500, Batavia, Illinois 60510 (United States); Department of Physics and Oklahoma Center for High Energy Physics, Oklahoma State University, Stillwater, Oklahoma 74078 (United States)

    2009-04-01T23:59:59.000Z

    We propose a new framework for understanding the hierarchies of fermion masses and mixings. The masses and mixings of all standard model (SM) charged fermions other than top arise from higher dimensional operators involving a messenger scalar S and flavon scalars F{sub i}. The flavons spontaneously break SM flavor symmetries at around the TeV scale. The SM singlet scalar S couples directly to the Higgs H and spontaneously breaks another U(1) at the electroweak scale. At the TeV scale, SM quarks and charged leptons have renormalizable couplings to S, but not to H or F{sub i}. These couplings involve new heavy vectorlike fermions. Integrating out these fermions produces a pattern of higher dimensional operators that reproduce the observed hierarchies of the SM masses and mixings in terms of powers of the 'little hierarchy': the ratio of the electroweak scale to the flavor-breaking scale. The framework has important phenomenological implications. Flavor-changing neutral currents are within experimental limits but D{sup 0}-D{sup 0} mixing and B{sub s}{yields}{mu}{sup +}{mu}{sup -} could be close to current sensitivities. The neutral scalar s of the messenger field mixes with the light Higgs of the SM, which can have strong effects on Higgs decay branching fractions. The s mass eigenstate may be lighter than the Higgs, and could be detected at the Tevatron or the LHC.

  19. Canonical Gauge Coupling Unification in the Standard Model with High-Scale Supersymmetry Breaking

    E-Print Network [OSTI]

    Yun-Jie Huo; Tianjun Li; Dimitri V. Nanopoulos

    2011-08-24T23:59:59.000Z

    Inspired by the string landscape and the unified gauge coupling relation in the F-theory Grand Unified Theories (GUTs) and GUTs with suitable high-dimensional operators, we study the canonical gauge coupling unification and Higgs boson mass in the Standard Model (SM) with high-scale supersymmetry breaking. In the SM with GUT-scale supersymmetry breaking, we achieve the gauge coupling unification at about 5.3 x 10^{13} GeV, and the Higgs boson mass is predicted to range from 130 GeV to 147 GeV. In the SM with supersymmetry breaking scale from 10^4 GeV to 5.3 x 10^{13} GeV, gauge coupling unification can always be realized and the corresponding GUT scale M_U is from 10^{16} GeV to 5.3 x 10^{13} GeV, respectively. Also, we obtain the Higgs boson mass from 114.4 GeV to 147 GeV. Moreover, the discrepancies among the SM gauge couplings at the GUT scale are less than about 4-6%. Furthermore, we present the SU(5) and SO(10) models from the F-theory model building and orbifold constructions, and show that we do not have the dimension-five and dimension-six proton decay problems even if M_U \\le 5 x 10^{15} GeV.

  20. Simulation of a main steam line break with steam generator tube rupture using trace

    SciTech Connect (OSTI)

    Gallardo, S.; Querol, A.; Verdu, G. [Departamento de Ingenieria Quimica Y Nuclear, Universitat Politecnica de Valencia, Camino de Vera s/n, 46022, Valencia (Spain)

    2012-07-01T23:59:59.000Z

    A simulation of the OECD/NEA ROSA-2 Project Test 5 was made with the thermal-hydraulic code TRACE5. Test 5 performed in the Large Scale Test Facility (LSTF) reproduced a Main Steam Line Break (MSLB) with a Steam Generator Tube Rupture (SGTR) in a Pressurized Water Reactor (PWR). The result of these simultaneous breaks is a depressurization in the secondary and primary system in loop B because both systems are connected through the SGTR. Good approximation was obtained between TRACE5 results and experimental data. TRACE5 reproduces qualitatively the phenomena that occur in this transient: primary pressure falls after the break, stagnation of the pressure after the opening of the relief valve of the intact steam generator, the pressure falls after the two openings of the PORV and the recovery of the liquid level in the pressurizer after each closure of the PORV. Furthermore, a sensitivity analysis has been performed to know the effect of varying the High Pressure Injection (HPI) flow rate in both loops on the system pressures evolution. (authors)