National Library of Energy BETA

Sample records for double-strand break repair

  1. Detection and Repair of Ionizing Radiation-Induced DNA Double Strand Breaks: New Developments in Nonhomologous End Joining

    SciTech Connect (OSTI)

    Wang, Chen [Departments of Biochemistry and Molecular Biology and Oncology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary (Canada)] [Departments of Biochemistry and Molecular Biology and Oncology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary (Canada); Lees-Miller, Susan P., E-mail: leesmill@ucalgary.ca [Departments of Biochemistry and Molecular Biology and Oncology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary (Canada)

    2013-07-01

    DNA damage can occur as a result of endogenous metabolic reactions and replication stress or from exogenous sources such as radiation therapy and chemotherapy. DNA double strand breaks are the most cytotoxic form of DNA damage, and defects in their repair can result in genome instability, a hallmark of cancer. The major pathway for the repair of ionizing radiation-induced DSBs in human cells is nonhomologous end joining. Here we review recent advances on the mechanism of nonhomologous end joining, as well as new findings on its component proteins and regulation.

  2. The COP9 signalosome is vital for timely repair of DNA double-strand breaks

    E-Print Network [OSTI]

    Meir, Michal; Galanty, Yaron; Kashani, Lior; Blank, Michael; Khosravi, Rami; Fernández-Ávila, María Jesús; Cruz-García, Andrés; Star, Ayelet; Shochot, Lea; Thomas, Yann; Garrett, Lisa J.; Chamovitz, Daniel A.; Bodine, David M.; Kurz, Thimo; Huertas, Pablo; Ziv, Yael; Shiloh, Yosef

    2015-04-08

    is critical for proper DSB repair, and that loss of this phosphorylation site alone is sufficient to cause a DDR deficiency phenotype in the mouse. This novel branch of the DSB response thus significantly affects genome stability....

  3. Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions

    SciTech Connect (OSTI)

    Zafar, Faria; Seidler, Sara B.; Kronenberg, Amy; Schild, David; Wiese, Claudia

    2010-06-29

    To test the contribution of homologous recombinational repair (HRR) in repairing DNA damaged sites induced by high-energy iron ions, we used: (1) HRR-deficient rodent cells carrying a deletion in the RAD51D gene and (2) syngeneic human cells impaired for HRR by RAD51D or RAD51 knockdown using RNA interference. We show that in response to iron ions, HRR contributes to cell survival in rodent cells, and that HRR-deficiency abrogates RAD51 foci formation. Complementation of the HRR defect by human RAD51D rescues both enhanced cytotoxicity and RAD51 foci formation. For human cells irradiated with iron ions, cell survival is decreased, and, in p53 mutant cells, the levels of mutagenesis are increased when HRR is impaired. Human cells synchronized in S phase exhibit more pronounced resistance to iron ions as compared with cells in G1 phase, and this increase in radioresistance is diminished by RAD51 knockdown. These results implicate a role for RAD51-mediated DNA repair (i.e. HRR) in removing a fraction of clustered lesions induced by charged particle irradiation. Our results are the first to directly show the requirement for an intact HRR pathway in human cells in ensuring DNA repair and cell survival in response to high-energy high LET radiation.

  4. Zinc chromate induces chromosome instability and DNA double strand breaks in human lung cells

    SciTech Connect (OSTI)

    Xie Hong; Holmes, Amie L.; Young, Jamie L.; Qin Qin; Joyce, Kellie; Pelsue, Stephen C.; Peng Cheng; Wise, Sandra S.; Jeevarajan, Antony S.; Wallace, William T.; Hammond, Dianne; Wise, John Pierce E-mail: John.Wise@usm.maine.edu

    2009-02-01

    Hexavalent chromium Cr(VI) is a respiratory toxicant and carcinogen, with solubility playing an important role in its carcinogenic potential. Zinc chromate, a water insoluble or 'particulate' Cr(VI) compound, has been shown to be carcinogenic in epidemiology studies and to induce tumors in experimental animals, but its genotoxicity is poorly understood. Our study shows that zinc chromate induced concentration-dependent increases in cytotoxicity, chromosome damage and DNA double strand breaks in human lung cells. In response to zinc chromate-induced breaks, MRE11 expression was increased and ATM and ATR were phosphorylated, indicating that the DNA double strand break repair system was initiated in the cells. In addition, our data show that zinc chromate-induced double strand breaks were only observed in the G2/M phase population, with no significant amount of double strand breaks observed in G1 and S phase cells. These data will aid in understanding the mechanisms of zinc chromate toxicity and carcinogenesis.

  5. Exploitation of the genomic double-strand breaks to reduce the reproductive power of microorganisms

    E-Print Network [OSTI]

    Sassi, Giandomenico

    2015-01-01

    It is shown how to take advantage of the frequent occurrence of double-strand breaks in the genome of prokaryotic cells, in order to reduce their high efficient reproductive capability. The analysis examines the physical status of the free ends of each break and considers how this status can interfere with an external physical apparatus, with the aim of undermining the repair processes. We indicate the biological consequences of this interaction and we give an approximate evaluation of the topological and dynamical effects that arise on the genomic material involved. The overall result suggests a significant reduction of the dynamics of the repair.

  6. Processing of 3'-Phosphoglycolate-Terminated DNA Double-StrandBreaks by Artemis Nuclease

    SciTech Connect (OSTI)

    Povrik, Lawrence F.; Zhou, Tong; Zhou, Ruizhe; Cowan, Morton J.; Yannone, Steven M.

    2005-10-01

    The Artemis nuclease is required for V(D)J recombination and for repair of an as yet undefined subset of radiation-induced DNA double-strand breaks. To assess the possibility that Artemis functions on oxidatively modified double-strand break termini, its activity toward model DNA substrates, bearing either 3{prime}-hydroxyl or 3{prime}-phosphoglycolate moieties, was examined. A 3{prime}-phosphoglycolate had little effect on Artemis-mediated trimming of long 3{prime} overhangs (>9 nucleotides), which were efficiently trimmed to 4-5 nucleotides. However, 3{prime}-phosphoglycolates on overhangs of 4-5 bases promoted selective Artemis-mediated trimming of a single 3{prime}-terminal nucleotide, while at least 2 nucleotides were trimmed from identical hydroxyl-terminated substrates. Artemis also efficiently removed a single nucleotide from a phosphoglycolate-terminated 3-base 3{prime} overhang, while leaving an analogous hydroxyl-terminated overhang largely intact. Such removal was dependent upon Ku, DNA-dependent protein kinase, and ATP. Together, these data suggest that Artemis-mediated cleavage of 3{prime} overhangs requires a minimum of 2 nucleotides, or a nucleotide plus a phosphoglycolate, 3{prime} to the cleavage site. Shorter 3{prime}-phosphoglycolate-terminated overhangs and blunt ends were also processed by Artemis, but much less efficiently. Consistent with the in vitro substrate specificity of Artemis, human cells lacking Artemis exhibited hypersensitivity to X-rays, bleomycin and neocarzinostatin, which all induce 3{prime}-phosphoglycolate-terminated double-strand breaks. Collectively, these results suggest that 3{prime}-phosphoglycolate termini and/or specific classes of DNA ends that arise from such blocked termini are relevant Artemis substrates in vivo.

  7. Microbial Pathogens Trigger Host DNA Double-Strand Breaks Whose Abundance Is Reduced by Plant Defense

    E-Print Network [OSTI]

    of an alternative mediator of pathogen-induced H2AX phosphorylation. In summary, pathogenic microorganisms canMicrobial Pathogens Trigger Host DNA Double-Strand Breaks Whose Abundance Is Reduced by Plant largely unknown. We report that multiple bacterial, fungal and oomycete plant pathogen species induce

  8. The probability of double-strand breaks in giant DNA decreases markedly as the DNA concentration increases

    E-Print Network [OSTI]

    Shimobayashi, Shunsuke F; Mori, Toshiaki; Yoshikawa, Kenichi

    2012-01-01

    DNA double-strand breaks (DSBs) represent a serious source of damage for all living things and thus there have been many quantitative studies of DSBs both in vivo and in vitro. Despite this fact, the processes that lead to their production have not yet been clearly understood, and there is no established theory that can account for the statistics of their production, in particular, the number of DSBs per base pair per unit Gy, here denoted by P1, which is the most important parameter for evaluating the degree of risk posed by DSBs. Here, using the single-molecule observation method with giant DNA molecules (166 kbp), we evaluate the number of DSBs caused by gamma-ray irradiation. We find that P1 is nearly inversely proportional to the DNA concentration above a certain threshold DNA concentration. A simple model that accounts for the marked decrease of P1 shows that it is necessary to consider the characteristics of giant DNA molecules as semiflexible polymers to interpret the intrinsic mechanism of DSBs.

  9. Probability of double-strand breaks in genome-sized DNA by {gamma}-ray decreases markedly as the DNA concentration increases

    SciTech Connect (OSTI)

    Shimobayashi, Shunsuke F.; Iwaki, Takafumi; Mori, Toshiaki; Yoshikawa, Kenichi

    2013-05-07

    By use of the single-molecule observation, we count the number of DNA double-strand breaks caused by {gamma}-ray irradiation with genome-sized DNA molecules (166 kbp). We find that P{sub 1}, the number of double-strand breaks (DSBs) per base pair per unit Gy, is nearly inversely proportional to the DNA concentration above a certain threshold DNA concentration. The inverse relationship implies that the total number of DSBs remains essentially constant. We give a theoretical interpretation of our experimental results in terms of attack of reactive species upon DNA molecules, indicating the significance of the characteristics of genome-sized giant DNA as semiflexible polymers for the efficiency of DSBs.

  10. Induction and Rejoining of DNA Double Strand Breaks Assessed by H2AX Phosphorylation in Melanoma Cells Irradiated with Proton and Lithium Beams

    SciTech Connect (OSTI)

    Ibanez, Irene L.; Bracalente, Candelaria; Molinari, Beatriz L.; Palmieri, Monica A.; Policastro, Lucia; Kreiner, Andres J.; Burlon, Alejandro A.; Valda, Alejandro; Navalesi, Daniela; Davidson, Jorge; Davidson, Miguel; Vazquez, Monica; Ozafran, Mabel; Duran, Hebe

    2009-07-15

    Purpose: The aim of this study was to evaluate the induction and rejoining of DNA double strand breaks (DSBs) in melanoma cells exposed to low and high linear energy transfer (LET) radiation. Methods and Materials: DSBs and survival were determined as a function of dose in melanoma cells (B16-F0) irradiated with monoenergetic proton and lithium beams and with a gamma source. Survival curves were obtained by clonogenic assay and fitted to the linear-quadratic model. DSBs were evaluated by the detection of phosphorylated histone H2AX ({gamma}H2AX) foci at 30 min and 6 h post-irradiation. Results: Survival curves showed the increasing effectiveness of radiation as a function of LET. {gamma}H2AX labeling showed an increase in the number of foci vs. dose for all the radiations evaluated. A decrease in the number of foci was found at 6 h post-irradiation for low LET radiation, revealing the repair capacity of DSBs. An increase in the size of {gamma}H2AX foci in cells irradiated with lithium beams was found, as compared with gamma and proton irradiations, which could be attributed to the clusters of DSBs induced by high LET radiation. Foci size increased at 6 h post-irradiation for lithium and proton irradiations in relation with persistent DSBs, showing a correlation with surviving fraction. Conclusions: Our results showed the response of B16-F0 cells to charged particle beams evaluated by the detection of {gamma}H2AX foci. We conclude that {gamma}H2AX foci size is an accurate parameter to correlate the rejoining of DSBs induced by different LET radiations and radiosensitivity.

  11. Crystal Structure of E. coli RecE Protein Reveals a Toroidal Tetramer for Processing Double-Stranded DNA Breaks

    SciTech Connect (OSTI)

    Zhang, Jinjin; Xing, Xu; Herr, Andrew B.; Bell, Charles E.; (OSU); (UCIN)

    2009-07-21

    Escherichia coli RecE protein is part of the classical RecET recombination system that has recently been used in powerful new methods for genetic engineering. RecE binds to free double-stranded DNA (dsDNA) ends and processively digests the 5{prime}-ended strand to form 5{prime}-mononucleotides and a 3{prime}-overhang that is a substrate for single strand annealing promoted by RecT. Here, we report the crystal structure of the C-terminal nuclease domain of RecE at 2.8 {angstrom} resolution. RecE forms a toroidal tetramer with a central tapered channel that is wide enough to bind dsDNA at one end, but is partially plugged at the other end by the C-terminal segment of the protein. Four narrow tunnels, one within each subunit of the tetramer, lead from the central channel to the four active sites, which lie about 15 {angstrom} from the channel. The structure, combined with mutational studies, suggests a mechanism in which dsDNA enters through the open end of the central channel, the 5{prime}-ended strand passes through a tunnel to access one of the four active sites, and the 3{prime}-ended strand passes through the plugged end of the channel at the back of the tetramer.

  12. Double stranded nucleic acid biochips

    DOE Patents [OSTI]

    Chernov, Boris; Golova, Julia

    2006-05-23

    This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector that includes a linker for immobilization on a matrix. A non-enzymatic method for synthesizing double-stranded nucleic acids with this novel connector enables the construction of inexpensive and robust dsDNA/dsRNA microarrays. DNA-DNA and DNA-protein interactions are investigated using the microarrays.

  13. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

    E-Print Network [OSTI]

    Ochi, Takashi; Blackford, Andrew N.; Coates, Julia; Jhujh, Satpal; Mehmood, Shahid; Tamura, Naoka; Travers, Jon; Wu, Qian; Draviam, Viji M.; Robinson, Carol V.; Blundell, Tom L.; Jackson, Stephen P.

    2015-01-09

    regions of PAXX1-204 and PAXXV199A/F201A were amplified from the vectors by PCR and cloned into the pcDNA3.1(-) vector (a gift from Dr. V. Bolanos-Garcia) together with GFP or FLAG tags using In-Fusion (Clontech). Vectors were sequenced by the DNA... -treated or treated for 1 hour with 300 µM phleomycin to induce large numbers of DSBs, before being harvested either at this point or after an additional 1-hour recovery period in phleomycin-free medium after three PBS washes. Cells were washed twice in ice-cold PBS...

  14. Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity

    E-Print Network [OSTI]

    California at Berkeley, University of

    to benzene-induced hematotoxicity Min Shen1,Ã, Qing Lan1 , Luoping Zhang2 , Stephen Chanock1,3 , Guilan Li4; Email: shenmi@mail.nih.gov Benzene is a recognized hematotoxicant and carcinogen that produces genotoxic and indirectly by benzene metabolites. DSB may lead to chromosome aberrations, apoptosis and hematopoietic

  15. Suberoylanilide Hydroxyamic Acid Modification of Chromatin Architecture Affects DNA Break Formation and Repair

    SciTech Connect (OSTI)

    Singh, Sheetal; Le Hongan; Shih, S.-J.; Ho, Bay [Department of Radiation Oncology, University of California at Davis, 4501 X St., Sacramento, California 95817 (United States); Vaughan, Andrew T., E-mail: andrew.vaughan@ucdmc.ucdavis.ed [Department of Radiation Oncology, University of California at Davis, 4501 X St., Sacramento, California 95817 (United States); Department of Veterans Affairs, Mather, California 95655 (United States)

    2010-02-01

    Purpose: Chromatin-modifying compounds that inhibit the activity of histone deacetylases have shown potency as radiosensitizers, but the action of these drugs at a molecular level is not clear. Here we investigated the effect of suberoylanilide hydroxyamic acid (SAHA) on DNA breaks and their repair and induction of rearrangements. Methods and Materials: The effect of SAHA on both clonogenic survival and repair was assessed using cell lines SCC-25, MCF7, and TK6. In order to study unique DNA double-strand breaks, anti-CD95 antibody was employed to introduce a DNA double-strand break at a known location within the 11q23 region. The effects of SAHA on DNA cleavage and rearrangements were analyzed by ligation-mediated PCR and inverse PCR, respectively. Results: SAHA acts as radiosensitizer at 1 {mu}M, with dose enhancement factors (DEFs) at 10% survival of: SCC-25 - 1.24 +- 0.05; MCF7 - 1.16 +- 0.09 and TK6 - 1.17 +- 0.05, and it reduced the capacity of SCC-25 cells to repair radiation induced lesions. Additionally, SAHA treatment diffused site-specific fragmentation over at least 1 kbp in TK6 cells. Chromosomal rearrangements produced in TK6 cells exposed to SAHA showed a reduction in microhomology at the breakpoint between 11q23 and partner chromosomes. Conclusions: SAHA shows efficacy as a radiosensitizer at clinically obtainable levels. In its presence, targeted DNA strand breaks occur over an expanded region, indicating increased chromatin access. The rejoining of such breaks is degraded by SAHA when measured as rearrangements at the molecular level and rejoining that contributes to cell survival.

  16. Repair of DNA double strand breaks and radiosensitivity: modulation of DNA repair and radiosensitivity by microRNA-335 and mtPAP

    E-Print Network [OSTI]

    Martin, Nathan

    2014-01-01

    DDR by at least three mechanisms: 1) maintaining ROS homeostasis, 2) mediating apoptotic signals, and 3) producing energy

  17. Identification, Exploitation and Manipulation of BRCA1-Dependent DNA Double-Strand Break and Interstrand Crosslink Repair in Breast and Ovarian Cancer Therapy

    E-Print Network [OSTI]

    Stecklein, Shane Richard

    2012-05-12

    motif-containing protein 1 (gene) RING Really interesting new gene domain SCE Sister chromatid exchange xxiii SEM Standard error of the mean shRNA Short hairpin RNA ssDNA single-strand DNA TAE Tris-acetate-EDTA TN Triple...

  18. Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA glycosylase

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Schormann, Norbert; Banerjee, Surajit; Ricciardi, Robert; Chattopadhyay, Debasish

    2015-06-02

    Background: Uracil-DNA glycosylases are evolutionarily conserved DNA repair enzymes. However, vaccinia virus uracil-DNA glycosylase (known as D4), also serves as an intrinsic and essential component of the processive DNA polymerase complex during DNA replication. In this complex D4 binds to a unique poxvirus specific protein A20 which tethers it to the DNA polymerase. At the replication fork the DNA scanning and repair function of D4 is coupled with DNA replication. So far, DNA-binding to D4 has not been structurally characterized. Results: This manuscript describes the first structure of a DNA-complex of a uracil-DNA glycosylase from the poxvirus family. This alsomore »represents the first structure of a uracil DNA glycosylase in complex with an undamaged DNA. In the asymmetric unit two D4 subunits bind simultaneously to complementary strands of the DNA double helix. Each D4 subunit interacts mainly with the central region of one strand. DNA binds to the opposite side of the A20-binding surface on D4. In comparison of the present structure with the structure of uracil-containing DNA-bound human uracil-DNA glycosylase suggests that for DNA binding and uracil removal D4 employs a unique set of residues and motifs that are highly conserved within the poxvirus family but different in other organisms. Conclusion: The first structure of D4 bound to a truly non-specific undamaged double-stranded DNA suggests that initial binding of DNA may involve multiple non-specific interactions between the protein and the phosphate backbone.« less

  19. Spin transport and spin polarization properties in double-stranded DNA

    SciTech Connect (OSTI)

    Simchi, Hamidreza; Esmaeilzadeh, Mahdi Mazidabadi, Hossein

    2013-11-21

    We study the spin-dependent electron transport through a double-stranded DNA (dsDNA) using the Bogoliubov-de Gennes equations and non-equilibrium Green's function method. We calculate the spin-dependent electron conductance and spin-polarization for different lengths, helix angles, twist angles of dsDNA, the environment-induced dephasing factors, and hopping integral. It is shown that the conductance decreases by increasing the length and dephasing factor. Also, we show that the spin-polarization depends on the helical symmetry and the length of DNA. It is shown that the double-stranded DNA can act as a perfect spin filter. Finally, we show that the sign of spin polarization can be inverted from +1 (?1) to ?1 (+1) for some values of hopping integral.

  20. The effect of a magnetic field on the spin-selective transport in double-stranded DNA

    SciTech Connect (OSTI)

    Simchi, Hamidreza; Esmaeilzadeh, Mahdi Mazidabadi, Hossein

    2014-05-28

    Spin-polarization in double-stranded DNA is studied in the presence of a magnetic field applied along its helix axis using the non-equilibrium Green's function method. The spin-polarization could be tuned by changing the magnetic field. In some special cases, the double-stranded DNA behaved as a perfect spin-filter. Furthermore, the dependency of the spin-polarization on the spin-orbit strength and dephasing strength is studied.

  1. Translocation frequency of double-stranded DNA through a solid-state nanopore

    E-Print Network [OSTI]

    Bell, Nicholas A W; Keyser, Ulrich F

    2015-01-01

    Solid-state nanopores are single molecule sensors that measure changes in ionic current as charged polymers such as DNA pass through. Here, we present comprehensive experiments on the length, voltage and salt dependence of the frequency of double-stranded DNA translocations through conical quartz nanopores with mean opening diameter 15 nm. We observe an entropic barrier limited, length dependent translocation frequency at 4M LiCl salt concentration and a drift-dominated, length independent translocation frequency at 1M KCl salt concentration. These observations are described by a unifying convection-diffusion equation which includes the contribution of an entropic barrier for polymer entry.

  2. Sequence-dependent spin-selective tunneling along double-stranded DNA

    E-Print Network [OSTI]

    Guo, Ai-Min

    2012-01-01

    We report spin-selective tunneling of electrons along natural and artificial double-stranded DNA (dsDNA) sandwiched by nonmagnetic leads. The results reveal that the spin polarization strongly depends on the dsDNA sequence and is dominated by its end segment. Both genomic and artificial dsDNA could be efficient spin filters. The spin-filtering effects are sensitive to point mutation which occurs in the end segment. These results are in good agreement with recent experiments and are robust against various types of disorder, and could help for designing DNA-based spintronic devices.

  3. Asymmetric quantum transport in a double-stranded Kronig-Penney model

    E-Print Network [OSTI]

    Taksu Cheon; Sergey S. Poghosyan

    2015-03-03

    We introduce a double-stranded Kronig-Penney model and analyze its transport properties. The asymmetric fluxes between two strands with suddenly alternating localization patterns are found as the energy is varied. The zero-size limit of the internal lines connecting two strands is examined using quantum graph vertices with four edges. We also consider a two-dimensional Kronig-Penney lattice with two types of alternating layers with $\\delta$ and $\\delta'$ connections, and show that the existence of energy bands in which the quantum flux can flow only in selected directions.

  4. Double-stranded DNA organization in bacteriophage heads: An alternative toroid-based model

    SciTech Connect (OSTI)

    Hud, N.V.

    1995-10-01

    Studies of the organization of double-stranded DNA within bacteriophage heads during the past four decades have produced a wealth of data. However, despite the presentation of numerous models, the true organization of DNA within phage heads remains unresolved. The observations of toroidal DNA structures in electron micrographs of phage lysates have long been cited as support for the organization of DNA in a spool-like fashion. This particular model, like all other models, has not been found to be consistent with all available data. Recently, the authors proposed that DNA within toroidal condensates produced in vitro is organized in a manner significantly different from that suggested by the spool model. This new toroid model has allowed the development of an alternative model for DNA organization within bacteriophage heads that is consistent with a wide range of biophysical data. Here the authors propose that bacteriophage DNA is packaged in a toroid that is folded into a highly compact structure.

  5. Proximity-induced superconductivity effect in a double-stranded DNA

    SciTech Connect (OSTI)

    Simchi, Hamidreza; Esmaeilzadeh, Mahdi Mazidabadi, Hossein

    2014-02-07

    We study the proximity-induced superconductivity effect in a double-stranded DNA by solving the Bogoliubov-de Gennes equations and taking into account the effect of thermal fluctuations of the twist angle between neighboring base pairs. We show that the electron conductance is spin-dependent and the conductance of spin up (down) increases (decreases) due to the spin-orbit coupling (SOC). It is found that, for T?

  6. Inhibition of Hsp27 Radiosensitizes Head-and-Neck Cancer by Modulating Deoxyribonucleic Acid Repair

    SciTech Connect (OSTI)

    Guttmann, David M.; Hart, Lori; Du, Kevin; Seletsky, Andrew; Koumenis, Constantinos

    2013-09-01

    Purpose: To present a novel method of tumor radiosensitization through Hsp27 knockdown using locked nucleic acid (LNA) and to investigate the role of Hsp27 in DNA double strand break (DSB) repair. Methods and Materials: Clonogenic survival assays, immunoblotting, the proximity ligation assay, and ?H2AX foci analysis were conducted in SQ20B and FaDu human head-and-neck cancer cell lines treated with Hsp27 LNA and Hsp27 short hairpin RNA (shRNA). Additionally, nude mice with FaDu flank tumors were treated with fractionated radiation therapy after pretreatment with Hsp27 LNA and monitored for tumor growth. Results: Hsp27 LNA and Hsp27 shRNA radiosensitized head-and-neck cancer cell lines in an Hsp27-dependent manner. Ataxia-Telangectasia Mutated-mediated DNA repair signaling was impaired in irradiated cells with Hsp27 knockdown. ATM kinase inhibition abrogated the radiosensitizing effect of Hsp27. Furthermore, Hsp27 LNA and shRNA both attenuated DNA repair kinetics after radiation, and Hsp27 was found to colocalize with ATM in both untreated and irradiated cells. Last, combined radiation and Hsp27 LNA treatment in tumor xenografts in nude mice suppressed tumor growth compared with either treatment alone. Conclusions: These results support a radiosensitizing property of Hsp27 LNA in vitro and in vivo, implicate Hsp27 in double strand break repair, and suggest that Hsp27 LNA might eventually serve as an effective clinical agent in the radiotherapy of head-and-neck cancer.

  7. Bubble dynamics in double stranded DNA : A Rouse chain based approach

    E-Print Network [OSTI]

    Rajarshi Chakrabarti

    2010-10-26

    We propose a model for the fluctuation dynamics of the local denaturation zones (bubbles) in double-stranded DNA. In our formulation, the DNA strand is model as a one dimensional Rouse chain confined at both the ends. The bubble is formed when the transverse displacement of the chain attains a critical value. This simple model effectively reproduces the autocorrelation function for the tagged base pair in the DNA strand as measured in the seminal single molecule experiment by Altan-Bonnet et. al (Phys. Rev. Lett. 90, 138101 (2003)). Although our model is mathematically similar to the one proposed by Chatterjee et al. (J. Chem. Phys. 127, 155104 (2007)) it goes beyond a single reaction coordinate description by incorporating the chain dynamics through a confined Rouse chain and thus considers the collective nature of the dynamics. Our model also shows that the autocorrelation function is very sensitive to the relaxation times of the normal modes of the chain, which is obvious since the fluctuation dynamics of the bubble has the contribution from the different normal modes of the chain.

  8. Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic ?-cells

    SciTech Connect (OSTI)

    Chen, Shan-Shan [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China) [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China); Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing (China); Jiang, Teng [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China)] [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China); Wang, Yi; Gu, Li-Ze [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China) [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China); Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing (China); Wu, Hui-Wen [Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing (China)] [Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing (China); Tan, Lan [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China)] [Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing (China); Guo, Jun, E-mail: Guoj@njmu.edu.cn [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China) [Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing (China); Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing (China)

    2014-01-17

    Highlights: •PKR can be activated by glucolipitoxicity and pro-inflammatory cytokines in ?-cells. •Activated PKR inhibited ?-cell proliferation by arresting cell cycle at G1 phase. •Activated PKR fully abrogated the pro-proliferative effects of IGF-I on ?-cells. -- Abstract: Double-stranded RNA-dependent protein kinase (PKR) is revealed to participate in the development of insulin resistance in peripheral tissues in type 2 diabetes (T2DM). Meanwhile, PKR is also characterized as a critical regulator of cell proliferation. To date, no study has focused on the impact of PKR on the proliferation of pancreatic ?-cells. Here, we adopted insulinoma cell lines and mice islet ?-cells to investigate: (1) the effects of glucolipotoxicity and pro-inflammatory cytokines on PKR activation; (2) the effects of PKR on proliferation of pancreatic ?-cells and its underlying mechanisms; (3) the actions of PKR on pro-proliferative effects of IGF-I and its underlying pathway. Our results provided the first evidence that PKR can be activated by glucolipitoxicity and pro-inflammatory cytokines in pancreatic ?-cells, and activated PKR significantly inhibited cell proliferation by arresting cell cycle at G1 phase. Reductions in cyclin D1 and D2 as well as increases in p27 and p53 were associated with the anti-proliferative effects of PKR, and proteasome-dependent degradation took part in the reduction of cyclin D1 and D2. Besides, PKR activation abrogated the pro-proliferative effects of IGF-I by activating JNK and disrupting IRS1/PI3K/Akt signaling pathway. These findings indicate that the anti-proliferative actions of PKR on pancreatic ?-cells may contribute to the pathogenesis of T2DM.

  9. From Breaking Bad to Worse: Exploiting Homologous DNA Repair Deficiency in Cancer

    E-Print Network [OSTI]

    Hemann, Michael

    DNA repair deficiencies are common among cancer cells and represent a potential vulnerability that might be exploited by targeting compensatory repair pathways. However, the identification of synthetically lethal combinations ...

  10. DNA Double-Strand Breaks Form in Bystander Cells after Microbeam Irradiation of Three-dimensional Human Tissue Models

    E-Print Network [OSTI]

    Brenner, David Jonathan

    Research Accelerator Facility, Center for Radiological Research, College of Physicians and Surgeons Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada; and 3 Radiological implications for cancer radiother- apy and diagnostic radiology as well as for human health in general

  11. DNA repair: Dynamic defenders against cancer and aging

    SciTech Connect (OSTI)

    Fuss, Jill O.; Cooper, Priscilla K.

    2006-04-01

    You probably weren't thinking about your body's cellular DNA repair systems the last time you sat on the beach in the bright sunshine. Fortunately, however, while you were subjecting your DNA to the harmful effects of ultraviolet light, your cells were busy repairing the damage. The idea that our genetic material could be damaged by the sun was not appreciated in the early days of molecular biology. When Watson and Crick discovered the structure of DNA in 1953 [1], it was assumed that DNA is fundamentally stable since it carries the blueprint of life. However, over 50 years of research have revealed that our DNA is under constant assault by sunlight, oxygen, radiation, various chemicals, and even our own cellular processes. Cleverly, evolution has provided our cells with a diverse set of tools to repair the damage that Mother Nature causes. DNA repair processes restore the normal nucleotide sequence and DNA structure of the genome after damage [2]. These responses are highly varied and exquisitely regulated. DNA repair mechanisms are traditionally characterized by the type of damage repaired. A large variety of chemical modifications can alter normal DNA bases and either lead to mutations or block transcription if not repaired, and three distinct pathways exist to remove base damage. Base excision repair (BER) corrects DNA base alterations that do not distort the overall structure of the DNA helix such as bases damaged by oxidation resulting from normal cellular metabolism. While BER removes single damaged bases, nucleotide excision repair (NER) removes short segments of nucleotides (called oligonucleotides) containing damaged bases. NER responds to any alteration that distorts the DNA helix and is the mechanism responsible for repairing bulky base damage caused by carcinogenic chemicals such as benzo [a]pyrene (found in cigarette smoke and automobile exhaust) as well as covalent linkages between adjacent pyrimidine bases resulting from the ultraviolet (UV) component of sunlight. NER can be divided into two classes based on where the repair occurs. NER occurring in DNA that is not undergoing transcription (i.e., most of the genome) is called global genome repair (GGR or GGNER), while NER taking place in the transcribed strand of active genes is called transcription-coupled repair (TCR or TC-NER). We will explore NER in more detail below. Mismatch repair (MMR) is another type of excision repair that specifically removes mispaired bases resulting from replication errors. DNA damage can also result in breaks in the DNA backbone, in one or both strands. Single-strand breaks (SSBs) are efficiently repaired by a mechanism that shares common features with the later steps in BER. Double-strand breaks (DSBs) are especially devastating since by definition there is no intact complementary strand to serve as a template for repair, and even one unrepaired DSB can be lethal [3]. In cells that have replicated their DNA prior to cell division, the missing information can be supplied by the duplicate copy, or sister chromatid, and DSBs in these cells are faithfully repaired by homologous recombination involving the exchange of strands of DNA between the two copies. However, most cells in the body are non-dividing, and in these cells the major mechanism for repairing DSBs is by non-homologous end joining (NHEJ), which as the name implies involves joining two broken DNA ends together without a requirement for homologous sequence and which therefore has a high potential for loss of genetic information.

  12. Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cunniffe, Siobhan; O’Neill, Peter; Greenberg, Marc M.; Lomax, Martine E.

    2014-04-01

    A signature of ionizing radiation is the induction of DNA clustered damaged sites. Non-double strand break (DSB) clustered damage has been shown to compromise the base excision repair pathway, extending the lifetimes of the lesions within the cluster, compared to isolated lesions. This increases the likelihood the lesions persist to replication and thus increasing the mutagenic potential of the lesions within the cluster. Lesions formed by ionizing radiation include 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and 2-deoxyribonolactone (dL). dL poses an additional challenge to the cell as it is not repaired by the short-patch base excision repair pathway. Here we show recalcitrant dL repairmore »is reflected in mutations observed when DNA containing it and a proximal 8-oxodGuo is replicated in Escherichia coli. 8-oxodGuo in close proximity to dL on the opposing DNA strand results in an enhanced frequency of mutation of the lesions within the cluster and a 20 base sequence flanking the clustered damage site in an E. coli based plasmid assay. In vitro repair of a dL lesion is reduced when compared to the repair of an abasic (AP) site and a tetrahydrofuran (THF), and this is due mainly to a reduction in the activity of polymerase ?, leading to retarded FEN1 and ligase 1 activities. This study has given insights in to the biological effects of clusters containing dL.« less

  13. Homologous recombination and non-homologous end-joining repair pathways in bovine embryos with different developmental competence

    SciTech Connect (OSTI)

    Henrique Barreta, Marcos; Laboratorio de Biotecnologia e Reproducao Animal-BioRep, Universidade Federal de Santa Maria, Santa Maria, RS ; Garziera Gasperin, Bernardo; Braga Rissi, Vitor; Cesaro, Matheus Pedrotti de; Ferreira, Rogerio; Oliveira, Joao Francisco de; Goncalves, Paulo Bayard Dias; Bordignon, Vilceu

    2012-10-01

    This study investigated the expression of genes controlling homologous recombination (HR), and non-homologous end-joining (NHEJ) DNA-repair pathways in bovine embryos of different developmental potential. It also evaluated whether bovine embryos can respond to DNA double-strand breaks (DSBs) induced with ultraviolet irradiation by regulating expression of genes involved in HR and NHEJ repair pathways. Embryos with high, intermediate or low developmental competence were selected based on the cleavage time after in vitro insemination and were removed from in vitro culture before (36 h), during (72 h) and after (96 h) the expected period of embryonic genome activation. All studied genes were expressed before, during and after the genome activation period regardless the developmental competence of the embryos. Higher mRNA expression of 53BP1 and RAD52 was found before genome activation in embryos with low developmental competence. Expression of 53BP1, RAD51 and KU70 was downregulated at 72 h and upregulated at 168 h post-insemination in response to DSBs induced by ultraviolet irradiation. In conclusion, important genes controlling HR and NHEJ DNA-repair pathways are expressed in bovine embryos, however genes participating in these pathways are only regulated after the period of embryo genome activation in response to ultraviolet-induced DSBs.

  14. Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation

    SciTech Connect (OSTI)

    Lai, Chao-Kuen; Jeng, King-Song [Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan (China); Machida, Keigo [Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2001 Zonal Avenue, Los Angeles, CA 90033 (United States); Cheng, Yi-Sheng [Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan (China); Lai, Michael M.C. [Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan (China); Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2001 Zonal Avenue, Los Angeles, CA 90033 (United States)], E-mail: michlai@gate.sinica.edu.tw

    2008-01-20

    Hepatitis C virus (HCV) infection is frequently associated with the development of hepatocellular carcinomas and non-Hodgkin's B-cell lymphomas. Nonstructural protein 3 (NS3) of HCV possesses serine protease, nucleoside triphosphatase, and helicase activities, while NS4A functions as a cofactor for the NS3 serine protease. Here, we show that HCV NS3/4A interacts with the ATM (ataxia-telangiectasia mutated), a cellular protein essential for cellular response to irradiation. The expression of NS3/4A caused cytoplasmic translocation of either endogenous or exogenous ATM and delayed dephosphorylation of the phosphorylated ATM and {gamma}-H2AX following ionizing irradiation. As a result, the irradiation-induced {gamma}-H2AX foci persisted longer in the NS3/4A-expressing cells. Furthermore, these cells showed increased comet tail moment in single-cell electrophoresis assay, indicating increased double-strand DNA breaks. The cells harboring an HCV replicon also exhibited cytoplasmic localization of ATM and increased sensitivity to irradiation. These results demonstrate that NS3/4A impairs the efficiency of DNA repair by interacting with ATM and renders the cells more sensitive to DNA damage. This effect may contribute to HCV oncogenesis.

  15. RENAL SYSTEM DEVELOPMENT IN THE ZEBRAFISH: A BASIC NEPHROGENESIS MODEL

    E-Print Network [OSTI]

    Tank, Jennifer L.

    -diethylaminobenzaldehyde DL distal late dpi days post injection DSB double-stranded break ESRD end-stage renal disease HDR homology directed repair hpf hours post fertilization IM intermediate mesoderm indels insertion or deletion

  16. The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice

    E-Print Network [OSTI]

    Wiktor-Brown, Dominika M

    2007-01-01

    Mitotic homologous recombination is a critical pathway for the repair of DNA double-strand breaks and broken replication forks. Although homologous recombination is generally error-free, recombination between misaligned ...

  17. Turbine repair process, repaired coating, and repaired turbine component

    SciTech Connect (OSTI)

    Das, Rupak; Delvaux, John McConnell; Garcia-Crespo, Andres Jose

    2015-11-03

    A turbine repair process, a repaired coating, and a repaired turbine component are disclosed. The turbine repair process includes providing a turbine component having a higher-pressure region and a lower-pressure region, introducing particles into the higher-pressure region, and at least partially repairing an opening between the higher-pressure region and the lower-pressure region with at least one of the particles to form a repaired turbine component. The repaired coating includes a silicon material, a ceramic matrix composite material, and a repaired region having the silicon material deposited on and surrounded by the ceramic matrix composite material. The repaired turbine component a ceramic matrix composite layer and a repaired region having silicon material deposited on and surrounded by the ceramic matrix composite material.

  18. FastFEM: Breaking Wave Impact on Ships Wave breaking and wave impact on maritime structures are difficult to model

    E-Print Network [OSTI]

    Wirosoetisno, Djoko

    ships to oil rigs, repair vessels for offshore wind farms, rescue vessels, and coast guard vessels with structures. We aim to progress nonlinear and breaking wave interactions on offshore structures, in particular

  19. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Nancy Porter; Mike Sullivan; Chris Neary

    2003-05-01

    The two broad categories of deposited weld metal repair and fiber-reinforced composite repair technologies were reviewed for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Preliminary test programs were developed for both deposited weld metal repairs and for fiber-reinforced composite repair. To date, all of the experimental work pertaining to the evaluation of potential repair methods has focused on fiber-reinforced composite repairs. Hydrostatic testing was also conducted on four pipeline sections with simulated corrosion damage: two with composite liners and two without.

  20. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, Leo M. (Livermore, CA)

    1998-01-01

    Disclosed is a rapid road repair vehicle capable of moving over a surface to be repaired at near normal posted traffic speeds to scan for and find an the high rate of speed, imperfections in the pavement surface, prepare the surface imperfection for repair by air pressure and vacuum cleaning, applying a correct amount of the correct patching material to effect the repair, smooth the resulting repaired surface, and catalog the location and quality of the repairs for maintenance records of the road surface. The rapid road repair vehicle can repair surface imperfections at lower cost, improved quality, at a higher rate of speed than was was heretofor possible, with significantly reduced exposure to safety and health hazards associated with this kind of road repair activities in the past.

  1. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, L.M.

    1998-05-05

    Disclosed is a rapid road repair vehicle capable of moving over a surface to be repaired at near normal posted traffic speeds to scan for and find at the high rate of speed, imperfections in the pavement surface, prepare the surface imperfection for repair by air pressure and vacuum cleaning, applying a correct amount of the correct patching material to effect the repair, smooth the resulting repaired surface, and catalog the location and quality of the repairs for maintenance records of the road surface. The rapid road repair vehicle can repair surface imperfections at lower cost, improved quality, at a higher rate of speed than was not heretofor possible, with significantly reduced exposure to safety and health hazards associated with this kind of road repair activities in the past. 2 figs.

  2. Euler buckling and nonlinear kinking of double-stranded DNA

    E-Print Network [OSTI]

    Cohen, Adam E.

    physiological conditions: at high curvature, does the DNA bend smoothly, or does it kink like a drinking straw and damage). These aspects of DNA mechanics are likely to influence protein binding and DNA packaging, yet the effect of single-nucleotide mismatches on DNA bending. Our data support a model of linear elastic bending

  3. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Bill Bruce; Nancy Porter; George Ritter; Matt Boring; Mark Lozev; Ian Harris; Bill Mohr; Dennis Harwig; Robin Gordon; Chris Neary; Mike Sullivan

    2005-07-20

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. In lieu of a field installation on an abandoned pipeline, a preliminary nondestructive testing protocol is being developed to determine the success or failure of the fiber-reinforced liner pipeline repairs. Optimization and validation activities for carbon-fiber repair methods are ongoing.

  4. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-12-31

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. The first round of optimization and validation activities for carbon-fiber repairs are complete. Development of a comprehensive test plan for this process is recommended for use in the field trial portion of this program.

  5. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-08-17

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. Development of a comprehensive test plan for this process is recommended for use in the field trial portion of this program.

  6. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, Leo M. (Livermore, CA)

    1999-01-01

    Disclosed are improvments to a rapid road repair vehicle comprising an improved cleaning device arrangement, two dispensing arrays for filling defects more rapidly and efficiently, an array of pre-heaters to heat the road way surface in order to help the repair material better bond to the repaired surface, a means for detecting, measuring, and computing the number, location and volume of each of the detected surface imperfection, and a computer means schema for controlling the operation of the plurality of vehicle subsystems. The improved vehicle is, therefore, better able to perform its intended function of filling surface imperfections while moving over those surfaces at near normal traffic speeds.

  7. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; Nancy Porter; Mike Sullivan; Chris Neary

    2004-04-12

    The two broad categories of deposited weld metal repair and fiber-reinforced composite liner repair technologies were reviewed for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Preliminary test programs were developed for both deposited weld metal repair and for fiber-reinforced composite liner repair. Evaluation trials have been conducted using a modified fiber-reinforced composite liner provided by RolaTube and pipe sections without liners. All pipe section specimens failed in areas of simulated damage. Pipe sections containing fiber-reinforced composite liners failed at pressures marginally greater than the pipe sections without liners. The next step is to evaluate a liner material with a modulus of elasticity approximately 95% of the modulus of elasticity for steel. Preliminary welding parameters were developed for deposited weld metal repair in preparation of the receipt of Pacific Gas & Electric's internal pipeline welding repair system (that was designed specifically for 559 mm (22 in.) diameter pipe) and the receipt of 559 mm (22 in.) pipe sections from Panhandle Eastern. The next steps are to transfer welding parameters to the PG&E system and to pressure test repaired pipe sections to failure. A survey of pipeline operators was conducted to better understand the needs and performance requirements of the natural gas transmission industry regarding internal repair. Completed surveys contained the following principal conclusions: (1) Use of internal weld repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling (HDD) when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) Pipe diameter sizes range from 50.8 mm (2 in.) through 1,219.2 mm (48 in.). The most common size range for 80% to 90% of operators surveyed is 508 mm to 762 mm (20 in. to 30 in.), with 95% using 558.8 mm (22 in.) pipe. An evaluation of potential repair methods clearly indicates that the project should continue to focus on the development of a repair process involving the use of GMAW welding and on the development of a repair process involving the use of fiber-reinforced composite liners.

  8. Breaking Earth Poems

    E-Print Network [OSTI]

    Hernandez, Scott Mcnaul

    2012-01-01

    CALIFORNIA RIVERSIDE Breaking Earth Poems A Thesis submittedFestival……………………………………………………………………..…..14 Earth Against Mylittle else in their hands. Earth Against My Back I lay in

  9. Staged Program Repair in SPR (Supplementary Material)

    E-Print Network [OSTI]

    Long, Fan

    2015-03-05

    We present SPR, a new program repair system that uses condition synthesis to instantiate transformation schemas to repair program defects. SPR's staged repair strategy combines a rich space of potential repairs with a ...

  10. Window Replacement, Rehabilitation, & Repair Guides - Building...

    Energy Savers [EERE]

    Window Replacement, Rehabilitation, & Repair Guides - Building America Top Innovation Window Replacement, Rehabilitation, & Repair Guides - Building America Top Innovation Effec...

  11. Verification of Motor Repair Quality 

    E-Print Network [OSTI]

    Butler, K.

    1998-01-01

    is done properly. But how can an industrial customer know that the motor has been repaired properly?...

  12. Lorentz Breaking and Gravity

    E-Print Network [OSTI]

    R. Bluhm

    2013-07-22

    Gravitational theories with Lorentz violation must account for a number of possible features in order to be consistent theoretically and phenomenologically. A brief summary of these features is given here. They include evasion of a no-go theorem, connections between spontaneous Lorentz breaking and diffeomorphism breaking, the appearance of massless Nambu-Goldstone modes and massive Higgs modes, and the possibility of a Higgs mechanism in gravity.

  13. The influence of TRP53 in the dose response of radiation-induced apoptosis, DNA repair and genomic stability in murine haematopoietic cells

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lemon, Jennifer A.; Taylor, Kristina; Verdecchia, Kyle; Phan, Nghi; Boreham, Douglas R.

    2014-01-01

    Apoptotic and DNA damage endpoints are frequently used as surrogate markers of cancer risk, and have been well-studied in the Trp53+/- mouse model. We report the effect of differing Trp53 gene status on the dose response of ionizing radiation exposures (0.01-2 Gy), with the unique perspective of determining if effects of gene status remain at extended time points. Here we report no difference in the dose response for radiation-induced DNA double-strand breaks in bone marrow and genomic instability (MN-RET levels) in peripheral blood, between wild-type (Trp53+/+) and heterozygous (Trp53+/-) mice. The dose response for Trp53+/+ mice showed higher initial levelsmore »of radiation-induced lymphocyte apoptosis relative to Trp53+/- between 0 and 1 Gy. Although this trend was observed up to 12 hours post-irradiation, both genotypes ultimately reached the same level of apoptosis at 14 hours, suggesting the importance of late-onset p53-independent apoptotic responses in this mouse model. Expected radiation-induced G1 cell cycle delay was observed in Trp53+/+ but not Trp53+/-. Although p53 has an important role in cancer risk, we have shown its influence on radiation dose response can be temporally variable. This research highlights the importance of caution when using haematopoietic endpoints as surrogates to extrapolate radiation-induced cancer risk estimation.« less

  14. Strong Electroweak Symmetry Breaking

    E-Print Network [OSTI]

    Grinstein, Benjamin

    2011-01-01

    Models of spontaneous breaking of electroweak symmetry by a strong interaction do not have fine tuning/hierarchy problem. They are conceptually elegant and use the only mechanism of spontaneous breaking of a gauge symmetry that is known to occur in nature. The simplest model, minimal technicolor with extended technicolor interactions, is appealing because one can calculate by scaling up from QCD. But it is ruled out on many counts: inappropriately low quark and lepton masses (or excessive FCNC), bad electroweak data fits, light scalar and vector states, etc. However, nature may not choose the minimal model and then we are stuck: except possibly through lattice simulations, we are unable to compute and test the models. In the LHC era it therefore makes sense to abandon specific models (of strong EW breaking) and concentrate on generic features that may indicate discovery. The Technicolor Straw Man is not a model but a parametrized search strategy inspired by a remarkable generic feature of walking technicolor,...

  15. Service and Repair Work

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDidDevelopment Top Scientific Impact SinceService and Repair Work

  16. Awarded Products Maintenance, Repair & Operations TOOLS & HARDWARE

    E-Print Network [OSTI]

    California at San Diego, University of

    Awarded Products Maintenance, Repair & Operations (MRO): TOOLS & HARDWARE Such as hand and power tools, cutting tools, fasteners, etc. Maintenance, Repair & Operations (MRO): TOOLS & HARDWARE Such as hand and power tools, cutting tools, fasteners, etc. Maintenance, Repair & Operations (MRO): TOOLS

  17. Strong Electroweak Symmetry Breaking

    E-Print Network [OSTI]

    Benjamin Grinstein

    2011-02-19

    Models of spontaneous breaking of electroweak symmetry by a strong interaction do not have fine tuning/hierarchy problem. They are conceptually elegant and use the only mechanism of spontaneous breaking of a gauge symmetry that is known to occur in nature. The simplest model, minimal technicolor with extended technicolor interactions, is appealing because one can calculate by scaling up from QCD. But it is ruled out on many counts: inappropriately low quark and lepton masses (or excessive FCNC), bad electroweak data fits, light scalar and vector states, etc. However, nature may not choose the minimal model and then we are stuck: except possibly through lattice simulations, we are unable to compute and test the models. In the LHC era it therefore makes sense to abandon specific models (of strong EW breaking) and concentrate on generic features that may indicate discovery. The Technicolor Straw Man is not a model but a parametrized search strategy inspired by a remarkable generic feature of walking technicolor, that technivector mesons are light, narrow and decay readily into electroweak vector mesons and photons. While walking technicolor is popular among practitioners, alternatives exist and the Straw Man may not lead to their discovery.

  18. New Technologies for Repairing Aging Cables in Nuclear Power Plants

    SciTech Connect (OSTI)

    Simmons, Kevin L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fifield, Leonard S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Westman, Matthew P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2013-09-11

    The goal of this project is to demonstrate a proof-of-concept for a technique to repair aging cables that have been subjected to degradation associated with long-term thermal and radiation exposure in nuclear power plants. The physical degradation of the aging cables manifests itself primarily as cracking and increased brittleness of the polymeric electrical insulation. Therefore, the proposed cable-repair concept comprises development of techniques to impart a softening agent within the deteriorated polymer insulation jacket so as to regain the ability of the insulation to stretch without failing and possibly to heal existing cracks in the insulation. Our approach is to use commercially available ethylene-propylene rubber (EPR) as the relevant test material, demonstrate the adsorption of chemical treatments in the EPR and quantify changes in resulting physical and mechanical properties. EPR cable samples have been thermally treated in air to produce specimens corresponding to the full range of cable age-performance points from new (>350% elongation at break) to end-of-life (<50% elongation at break). The current focus is on two chemical treatments selected as candidates for restoring age-related cable elasticity loss: a rubber plasticizer and a reactive silane molecule. EPR specimens of 200, 150, 100, and 50% elongation at break have been soaked in the candidate chemical treatments and the kinetics of chemical uptake, measured by change in mass of the samples, has been determined. Mechanical properties as a function of aging and chemical treatment have been measured including ultimate tensile strength, tensile modulus at 50% strain, elongation at break, and storage modulus. Dimensional changes with treatment and changes in glass transition temperature were also investigated. These ongoing experiments are expected to provide insight into the physical-chemical nature of the effect of thermal degradation on EPR rejuvenation limits and to advance novel methods for restoring the ability of degraded EPR to be compliant and resist fracture. The results of this research reveal that absorption of chemical treatments can lower the glass transition temperature and modulus of EPR. Chemical treatments pursued thus far have proven ineffective at restoring EPR strength and elongation at break. Future work will combine the plasticizer modalities found to successfully increase the volume of the EPR, reduce EPR glass transition temperature and reduce EPR modulus with promising chemistries that will repair the damage of the polymer, potentially using the plasticizer as a host for the new chemistry.

  19. Selected Bibliography on Electric Motor Repair | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Selected Bibliography on Electric Motor Repair Selected Bibliography on Electric Motor Repair The following series of repair documents related to electric motors were produced by...

  20. The influence of TRP53 in the dose response of radiation-induced apoptosis, DNA repair and genomic stability in murine haematopoietic cells

    SciTech Connect (OSTI)

    Lemon, Jennifer A.; Taylor, Kristina; Verdecchia, Kyle; Phan, Nghi; Boreham, Douglas R.

    2014-01-01

    Apoptotic and DNA damage endpoints are frequently used as surrogate markers of cancer risk, and have been well-studied in the Trp53+/- mouse model. We report the effect of differing Trp53 gene status on the dose response of ionizing radiation exposures (0.01-2 Gy), with the unique perspective of determining if effects of gene status remain at extended time points. Here we report no difference in the dose response for radiation-induced DNA double-strand breaks in bone marrow and genomic instability (MN-RET levels) in peripheral blood, between wild-type (Trp53+/+) and heterozygous (Trp53+/-) mice. The dose response for Trp53+/+ mice showed higher initial levels of radiation-induced lymphocyte apoptosis relative to Trp53+/- between 0 and 1 Gy. Although this trend was observed up to 12 hours post-irradiation, both genotypes ultimately reached the same level of apoptosis at 14 hours, suggesting the importance of late-onset p53-independent apoptotic responses in this mouse model. Expected radiation-induced G1 cell cycle delay was observed in Trp53+/+ but not Trp53+/-. Although p53 has an important role in cancer risk, we have shown its influence on radiation dose response can be temporally variable. This research highlights the importance of caution when using haematopoietic endpoints as surrogates to extrapolate radiation-induced cancer risk estimation.

  1. Alternative Breaks Emergency Contact & Verification of Medical

    E-Print Network [OSTI]

    Tipple, Brett

    Alternative Breaks Emergency Contact & Verification of Medical Insurance Form Participant Name is STRONGLY RECCOMENDED, it is not required for participation in Alternative Breaks. *Please note: All

  2. Method of preparing and applying single stranded DNA probes to double stranded target DNAs in situ

    DOE Patents [OSTI]

    Gray, J.W.; Pinkel, D.

    1991-07-02

    A method is provided for producing single stranded non-self-complementary nucleic acid probes, and for treating target DNA for use therewith. The probe is constructed by treating DNA with a restriction enzyme and an exonuclease to form template/primers for a DNA polymerase. The digested strand is resynthesized in the presence of labeled nucleoside triphosphate precursor. Labeled single stranded fragments are separated from the resynthesized fragments to form the probe. Target DNA is treated with the same restriction enzyme used to construct the probe, and is treated with an exonuclease before application of the probe. The method significantly increases the efficiency and specificity of hybridization mixtures by increasing effective probe concentration by eliminating self-hybridization between both probe and target DNAs, and by reducing the amount of target DNA available for mismatched hybridizations. No Drawings

  3. Torsional regulation of hRPA-induced unwinding of double-stranded DNA

    E-Print Network [OSTI]

    Dekker, Cees

    and mechanism of the unwinding and rewinding reaction through single-molecule experiments. Human RPA (h Department of Cell Biology and Genetics, Cancer Genomic Center and 3 Department of Radiation OncologyDNA. Here, we study the dynamics of human RPA (hRPA) activity on topolog- ically constrained ds

  4. Screening Tool for Providers of Double-Stranded DNA - Energy Innovation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-ThroughputUpcomingmagnetoresistance | ArgonnePrinceton Plasma

  5. The biomechanics of cruciate ligament repair 

    E-Print Network [OSTI]

    Ferry, Katheryn Irene

    2013-02-22

    -1 THE BIOMECHAIVICS OF CR UCIA TE LIGAMEJV T REPAIR A Senior Thesis By Katheryn Irene Ferry 1997-98 University Undergraduate Research Fellow Texas A&M University Group: Engineering II THE BIOMECHANICS OF CRUCIATE LIGAMENT REPAIR by KATHRYN IRENE FERRY... by the The Biomechanics of Cruciate Ligament Repair femorotibial ligaments which include the collateral ligaments, the cranial cruciate ligament, and the caudal cruciate ligament (Vasseur, 1993). The anatomy and spatial arrangement of the femorotibial ligaments...

  6. Chiral Symmetry Breaking in Graphene

    E-Print Network [OSTI]

    Gordon W. Semenoff

    2011-08-19

    The question of whether the Coulomb interaction is strong enough to break the sublattice symmetry of un-doped graphene is discussed. We formulate a strong coupling expansion where the ground state of the Coulomb Hamiltonian is found exactly and the kinetic hopping Hamiltonian is treated as a perturbation. We argue that many of the properties of the resulting system would be shared by graphene with a Hubbard model interaction. In particular, the best candidate sublattice symmetry breaking ground state is an antiferromagnetic Mott insulator. We discuss the results of some numerical simulations which indicate that the Coulomb interaction is indeed subcritical. We also point out the curious fact that, if the electron did not have spin degeneracy, the tendency to break chiral symmetry would be much greater and even relatively weak Coulomb interactions would likely gap the spectrum.

  7. Chemical Fume Hood Maintenance, Repair and Certification

    E-Print Network [OSTI]

    Jia, Songtao

    in the lab. Removes lockout of hoods, if used. g. Notify EH&S to perform re-certification after repair

  8. Role of DNA repair protein ERCC1 in skin cancer 

    E-Print Network [OSTI]

    Song, Liang

    2009-01-01

    Nucleotide excision repair (NER) is one of the major repair systems for removal of DNA lesions. The NER pathway has evolved mainly to repair UV-induced DNA damage and is also active against a broad range of endogenously ...

  9. Baryon and chiral symmetry breaking

    SciTech Connect (OSTI)

    Gorsky, A. [Institute for Theoretical and Experimental Physics (ITEP), Moscow, Russia and Moscow Institute of Physics and Technology (MIPT), Dolgoprudny (Russian Federation); Krikun, A. [NORDITA, KTH Royal Institute of Technology and Stockholm University Stockholm, Sweden and Institute for Theoretical and Experimental Physics (ITEP), Moscow (Russian Federation)

    2014-07-23

    We briefly review the generalized Skyrmion model for the baryon recently suggested by us. It takes into account the tower of vector and axial mesons as well as the chiral symmetry breaking. The generalized Skyrmion model provides the qualitative explanation of the Ioffe’s formula for the baryon mass.

  10. Leveraging Service Calls and Emergency Repairs for Energy Efficiency...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Service Calls and Emergency Repairs for Energy Efficiency Marketing Leveraging Service Calls and Emergency Repairs for Energy Efficiency Marketing Better Buildings Residential...

  11. Solar Water Heating System Maintenance and Repair | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Solar Water Heating System Maintenance and Repair Solar Water Heating System Maintenance and Repair May 30, 2012 - 2:35pm Addthis Rooftop solar water heaters need regular...

  12. From Validation to Automated Repair & Beyond with Constraint Solving

    E-Print Network [OSTI]

    Samimi, Hesam

    2013-01-01

    HTML GenerationRepair: Automated Repair of HTML Generation Errors in PHPrenderings of our invalid HTML page in Google Chrome 13.0 (

  13. Plasma induced DNA damage: Comparison with the effects of ionizing radiation

    SciTech Connect (OSTI)

    Lazovi?, S.; Maleti?, D.; Pua?, N.; Malovi?, G.; Petrovi?, Z. Lj.; Leskovac, A.; Filipovi?, J.; Joksi?, G.

    2014-09-22

    We use human primary fibroblasts for comparing plasma and gamma rays induced DNA damage. In both cases, DNA strand breaks occur, but of fundamentally different nature. Unlike gamma exposure, contact with plasma predominantly leads to single strand breaks and base-damages, while double strand breaks are mainly consequence of the cell repair mechanisms. Different cell signaling mechanisms are detected confirming this (ataxia telangiectasia mutated - ATM and ataxia telangiectasia and Rad3 related - ATR, respectively). The effective plasma doses can be tuned to match the typical therapeutic doses of 2?Gy. Tailoring the effective dose through plasma power and duration of the treatment enables safety precautions mainly by inducing apoptosis and consequently reduced frequency of micronuclei.

  14. INTERNAL REPAIR OF PIPELINES REVIEW & EVALUATION OF INTERNAL PIPELINE REPAIR TRIALS REPORT

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-09-01

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is generally ineffective at restoring the pressure containing capabilities of pipelines. Failure pressure for pipe repaired with carbon fiber-reinforced composite liner was greater than that of the un-repaired pipe section with damage, indicating that this type of liner is effective at restoring the pressure containing capability of pipe. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. Development of a comprehensive test plan for this process is recommended for use in the next phase of this project.

  15. SUSY Breaking and Light Gauginos

    E-Print Network [OSTI]

    Glennys R. Farrar

    1997-04-13

    Several supersymmetry breaking mechanisms do not produce dimension-3 operators. I show here that this scenario is consistent with present observations and has several significant virtues: i) When there are no dimension-3 SUSY-breaking operators there is no SUSY-CP problem. ii) SUSY-breaking need not occur through gauge singlets, so that the cosmological problems often encountered in hidden sector SUSY-breaking can be avoided. iii) Photino and gluino and $R$-hadron masses are naturally consistent with relic photinos providing the required dark matter density. Requiring spontaneous electroweak symmetry implies that scalar masses are mostly in the $\\sim 100$ GeV range. The gluino and photino are massless at tree level. At 1-loop, the gluino and photino masses at the ew scale are predicted to be $m_{\\gluino}\\sim 10 - 600$ MeV and $m_{\\photino} \\sim 100 - 1400$ MeV. New hadrons with mass $\\sim 1 \\frac{1}{2}$ GeV are predicted and described. The ``extra'' flavor singlet pseudoscalar in the $\\iota(1440)$ region which has been observed in several experiments is naturally interpreted as the mainly-$\\gluino \\gluino$ bound state which gets its mass via the QCD anomaly. Its superpartner, a gluon-gluino bound state, would be the lightest $R$-hadron. For the most interesting portions of parameter space the $R^0$ lifetime is $10^{-6} - 10^{-10}$ sec, so existing searches would not have been sensitive to it. Search strategies and other consequences of the scenario are briefly mentioned.

  16. Complete quantum measurements break entanglement

    E-Print Network [OSTI]

    Juha-Pekka Pellonpää

    2012-06-27

    Complete measurement of a quantum observable (POVM) is a measurement of the maximally refined version of the POVM. Complete measurements give information on multiplicities of measurement outcomes and can be viewed as state preparation procedures. Moreover, any observable can be measured completely. In this Letter, we show that a complete measurement breaks entanglement completely between the system, ancilla and their environment. Finally, consequences to the quantum Zeno effect and complete position measurements are discussed.

  17. Alternative Break Participant Expectations 2014-2015

    E-Print Network [OSTI]

    Tipple, Brett

    Alternative Break Participant Expectations 2014-2015 (These expectations apply for all Participants Social Justice 101 or 201 Training Pay for Alternative Break experience prior to departure and on time and procedures as they apply to the Alternative Break experience. Individuals are expected to remain substance

  18. DNA purification by triplex-affinity capture and affinity capture electrophoresis

    DOE Patents [OSTI]

    Cantor, C.R.; Ito, Takashi; Smith, C.L.

    1996-01-09

    The invention provides a method for purifying or isolating double stranded DNA intact using triple helix formation. The method includes the steps of complexing an oligonucleotide and double stranded DNA to generate a triple helix and immobilization of the triple helix on a solid phase by means of a molecular recognition system such as avidin/biotin. The purified DNA is then recovered intact by treating the solid phase with a reagent that breaks the bonds between the oligonucleotide and the intact double stranded DNA while not affecting the Watson-Crick base pairs of the double helix. The present invention also provides a method for purifying or isolating double stranded DNA intact by complexing the double stranded DNA with a specific binding partner and recovering the complex during electrophoresis by immobilizing it on a solid phase trap imbedded in an electrophoretic gel. 6 figs.

  19. Developments advance subsea pipelaying, inspection, repair

    SciTech Connect (OSTI)

    1997-09-15

    Recent advances in laying, inspecting, and repairing pipelines are helping to cut both costs and time. A new dredging system that employs jets to clear a subsea trench for pipelay received trials off Belgium last spring. Also, within the last year, projects in the Middle East and North Sea employed technologies that promise to make inspecting the surface of a subsea pipeline in difficult terrain easier, less time consuming, and therefore less costly. Plus, subsea repair of damaged pipelines may take less time with a new ``stabbable`` pipe connector. The paper describes jet dredging, inspection advance, support software, the North Sea site, and pipeline repair.

  20. Higgs Portal to Visible Supersymmetry Breaking

    E-Print Network [OSTI]

    K. -I. Izawa; Yuichiro Nakai; Takashi Shimomura

    2011-02-28

    We propose a supersymmetric extension of the standard model whose Higgs sector induces a spontaneous supersymmetry breaking by itself. Unlike the minimal extension, the current Higgs mass bound can be evaded even at the tree-level without the help of the soft breaking terms due to the usual hidden sector, as is reminiscent of the next to minimal case. We also have a possibly light pseudo-goldstino in our visible sector in addition to extra Higgs particles, both of which stem from supersymmetry breaking dynamics. In such a setup of visible supersymmetry breaking, we may see a part of supersymmetry breaking dynamics rather directly in future experiments.

  1. Reducing Your Leak Rate Without Repairing Leaks 

    E-Print Network [OSTI]

    Beals, C.

    2005-01-01

    below the header pressure have the added advantage of reducing the air consumption of equipment, as well as reducing the leak rate. Turn Off the Air to Idle Equipment In most plants, when production equipment operators shut off their equipment... of the reason why plant personnel often find leak repair unproductive. The other reason relates to the compressor controls. If the plant had several lubricated rotary screw compressors operating in modulation, repairing 2,000 cfm in leaks may only reduce...

  2. History of electroweak symmetry breaking

    E-Print Network [OSTI]

    T. W. B. Kibble

    2015-02-22

    In this talk, I recall the history of the development of the unified electroweak theory, incorporating the symmetry-breaking Higgs mechanism, as I saw it from my standpoint as a member of Abdus Salam's group at Imperial College. I start by describing the state of physics in the years after the Second World War, explain how the goal of a unified gauge theory of weak and electromagnetic interactions emerged, the obstacles encountered, in particular the Goldstone theorem, and how they were overcome, followed by a brief account of more recent history, culminating in the historic discovery of the Higgs boson in 2012.

  3. Breaking Points in Quartic Maps

    E-Print Network [OSTI]

    M. Romera; G. Pastor; M. -F. Danca; A. Martin; A. B. Orue; F. Montoya

    2014-12-18

    Dynamical systems, whether continuous or discrete, are used by physicists in order to study non-linear phenomena. In the case of discrete dynamical systems, one of the most used is the quadratic map depending on a parameter. However, some phenomena can depend alternatively of two values of the same parameter. We use the quadratic map $x_{n+1} =1-ax_{n}^{2} $ when the parameter alternates between two values during the iteration process. In this case, the orbit of the alternate system is the sum of the orbits of two quartic maps. The bifurcation diagrams of these maps present breaking points where abruptly change their evolution.

  4. Progress in Electroweak Symmetry Breaking

    E-Print Network [OSTI]

    Dawson, S

    2015-01-01

    In this talk, I discuss theoretical advances in understanding the properties of the Higgs boson and the implications for models of electroweak symmetry breaking. I begin by reviewing some of the recent progress in Standard Model calculations for Higgs boson production and decay rates, followed by a lightning tour of the use of effective field theories in the search for new physics in the Higgs sector. I end with a discussion of the complementarity of precision Higgs coupling measurements and direct searches for heavy particles for the discovery of Beyond the Standard Model physics in the electroweak sector.

  5. Total-derivative supersymmetry breaking

    SciTech Connect (OSTI)

    Haba, Naoyuki; Uekusa, Nobuhiro

    2010-05-15

    On an interval compactification in supersymmetric theory, boundary conditions for bulk fields must be treated carefully. If they are taken arbitrarily following the requirement that a theory is supersymmetric, the conditions could give redundant constraints on the theory. We construct a supersymmetric action integral on an interval by introducing brane interactions with which total-derivative terms under the supersymmetry transformation become zero due to a cancellation. The variational principle leads equations of motion and also boundary conditions for bulk fields, which determine boundary values of bulk fields. By estimating mass spectrum, spontaneous supersymmetry breaking in this simple setup can be realized in a new framework. This supersymmetry breaking does not induce a massless R axion, which is favorable for phenomenology. It is worth noting that fermions in hyper-multiplet, gauge bosons, and the fifth-dimensional component of gauge bosons can have zero-modes (while the other components are all massive as Kaluza-Klein modes), which fits the gauge-Higgs unification scenarios.

  6. QCD, Symmetry Breaking and the Random Lattice

    E-Print Network [OSTI]

    Saul D. Cohen

    2006-02-15

    According to the Nielsen-Ninomiya No-Go theorem, the doubling of fermions on the lattice cannot be suppressed in a chiral theory. Whereas Wilson and staggered fermions suppress doublers with explicit breaking of chiral symmetry, the random lattice does so by spontaneous chiral symmetry breaking even in the free theory. I present results for meson masses, the chiral condensate and fermionic eigenvalues from simulations of quenched QCD on random lattices in four dimensions, focusing on chiral symmetry breaking.

  7. NREL: Technology Transfer - Popular Mechanics: Scientists Break...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Popular Mechanics: Scientists Break This Virtual Power Grid to Save the Real One July 27, 2015 Popular Mechanics describes how NREL's Energy Systems Integration Facility (ESIF)...

  8. Alan Turing as a Statistician: Breaking the Code by Breaking the Bayesian Egg

    E-Print Network [OSTI]

    Wolfe, Patrick J.

    Alan Turing as a Statistician: Breaking the Code by Breaking the Bayesian Egg Joseph K. Blitzstein, Harvard University Alan Turing is widely considered the father of computer science. Yet even

  9. HYDROGEN EFFECTS ON LASER ENGINEERED NET SHAPE (LENS) REPAIRED WELDMENTS

    SciTech Connect (OSTI)

    Korinko, P; Thad Adams, T

    2006-10-06

    New methods of repairing mis-machined components are always of interest. In this study, an innovative method using Laser Engineered Net Shape{trademark} (LENS{reg_sign}) forming was used to repair intentionally mis-machined test articles. The components were repaired and subsequently hydrogen charged and burst tested. The LENS repair did not have an adverse effect on the solid state weld process that was used to repair the components. Hydrogen charged samples failed in a similar manner to the uncharged samples. Overall, the prospects for LENS repairing similar products are favorable and further work is encouraged.

  10. Gauge symmetry breaking in orbifold model building

    E-Print Network [OSTI]

    Michele Trapletti

    2006-11-02

    We review the gauge symmetry breaking mechanism due to orbifold projections in orbifold model building. We explicitly show the existence of a scale of breaking if such a symmetry breaking is due to freely-acting orbifold operators only, i.e. in case the breaking is realized non-locally in the internal space. We show that such a scale is related to the compactification moduli only, and that there are no extra continuous parameters, at least in semirealistic models with N=1 SUSY in four dimensions. In this sense, the mechanism is peculiarly different from the standard Higgs (or Hosotani) symmetry breaking mechanism. We show that the mechanism also differs from that present in standard orbifold models where, even in presence of discrete Wilson lines, a scale of breaking is generically missing, since the breaking is localized in specific points in the internal space. We review a set of background geometries where the described non-local breaking is realized, both in the case of two and six extra dimensions. In the latter case, relevant in string model building, we consider both heterotic and open string compactifications.

  11. Repairable chip bonding/interconnect process

    DOE Patents [OSTI]

    Bernhardt, Anthony F. (Berkeley, CA); Contolini, Robert J. (Livermore, CA); Malba, Vincent (Livermore, CA); Riddle, Robert A. (Tracy, CA)

    1997-01-01

    A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder.

  12. Repairable chip bonding/interconnect process

    DOE Patents [OSTI]

    Bernhardt, A.F.; Contolini, R.J.; Malba, V.; Riddle, R.A.

    1997-08-05

    A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules is disclosed. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder. 10 figs.

  13. Development of a composite repair system for reinforcing offshore risers 

    E-Print Network [OSTI]

    Alexander, Christopher Richard

    2009-05-15

    A research program was conducted to investigate the application of composite materials in repairing corroded offshore risers, leading to the development of an optimized repair using a hybrid carbon/E-glass system. The objective of this research...

  14. Solar Water Heating System Maintenance and Repair | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Water Heating System Maintenance and Repair Solar Water Heating System Maintenance and Repair May 30, 2012 - 2:35pm Addthis Rooftop solar water heaters need regular maintenance to...

  15. Repairable File and Storage Systems A Dissertation Presented

    E-Print Network [OSTI]

    Chiueh, Tzi-cker

    Repairable File and Storage Systems A Dissertation Presented by Ningning Zhu to The Graduate School of the Dissertation Repairable File and Storage System by Ningning Zhu Doctor of Philosophy in Computer Science Stony stream file/storage system. Repairable file/storage system needs to perform two tasks. First it has

  16. Asymptotic Interference Alignment for Exact Repair in Distributed Storage Systems

    E-Print Network [OSTI]

    Jafar, Syed A.

    Asymptotic Interference Alignment for Exact Repair in Distributed Storage Systems Viveck R. Cadambe consider a distributed storage system where a file of size M is stored in n distributed storage nodes using of this paper is to repair failed nodes in the storage system, by replacing them by their replicas (exact repair

  17. Emergency pipe line repair connects subsea pipe lines

    SciTech Connect (OSTI)

    Lerique, M.P.; Thiberge, P. ); Wright, N. )

    1990-11-01

    Emergency repair of any subsea line pipe must form a high-integrity, metal-to-metal seal. This paper presents a remote, diverless repair system that utilizes master flanges, a connector and a spool piece to repair line pipe in deep offshore waters.

  18. Level of Repair Analysis and Minimum Cost Homomorphisms of Graphs

    E-Print Network [OSTI]

    Gutin, Gregory

    of Lillian Barros Abstract. Level of Repair Analysis (LORA) is a prescribed procedure for defence logistics, LORA seeks to determine an optimal provision of repair and maintenance facilities to minimize overall on bipartite graphs is polynomial time solvable. Keywords: Computational Logistics; Level of Repair Analysis

  19. EPA Lead Safety for Renovation, Repair and

    E-Print Network [OSTI]

    Tennessee, University of

    EPA Lead Safety for Renovation, Repair and Painting (RRP) Course Certified Renovators Class, CSP, CHMM, Certified Lead Paint Inspector.; Certified Renovator; EPA Ac- credited Lead RRP trainer or fax registratio Registration Form Cash Method of Payment Check Name Mailing Address Phone Lead Safety

  20. Visualization of Mismatch Repair in Bacterial Cells

    E-Print Network [OSTI]

    Smith, Bradley T.

    We determined the localizations of mismatch repair proteins in living Bacillus subtilis cells. MutS-GFP colocalized with the chromosome in all cells and formed foci in a subset of cells. MutL-GFP formed foci in a subset ...

  1. Effective field theory for spacetime symmetry breaking

    E-Print Network [OSTI]

    Yoshimasa Hidaka; Toshifumi Noumi; Gary Shiu

    2014-12-17

    We discuss the effective field theory for spacetime symmetry breaking from the local symmetry point of view. By gauging spacetime symmetries, the identification of Nambu-Goldstone (NG) fields and the construction of the effective action are performed based on the breaking pattern of diffeomorphism, local Lorentz, and (an)isotropic Weyl symmetries as well as the internal symmetries including possible central extensions in nonrelativistic systems. Such a local picture distinguishes, e.g., whether the symmetry breaking condensations have spins and provides a correct identification of the physical NG fields, while the standard coset construction based on global symmetry breaking does not. We illustrate that the local picture becomes important in particular when we take into account massive modes associated with symmetry breaking, whose masses are not necessarily high. We also revisit the coset construction for spacetime symmetry breaking. Based on the relation between the Maurer-Cartan one form and connections for spacetime symmetries, we classify the physical meanings of the inverse Higgs constraints by the coordinate dimension of broken symmetries. Inverse Higgs constraints for spacetime symmetries with a higher dimension remove the redundant NG fields, whereas those for dimensionless symmetries can be further classified by the local symmetry breaking pattern.

  2. Laboratory Directed Research and Development Program. Annual report

    SciTech Connect (OSTI)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

  3. Laboratory Directed Research and Development Program

    SciTech Connect (OSTI)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

  4. Long Wave Breaking Effects on Fringing Reefs 

    E-Print Network [OSTI]

    Goertz, John 1985-

    2012-12-12

    Modeling of wave energy transformation and breaking on fringing reefs is inherently difficult due to the unique topography of reefs. Prior methods of determining dissipation are based on empirical data from gently sloping beaches and offer only bulk...

  5. Breaking Parity Symmetry Using Extra Dimensions

    E-Print Network [OSTI]

    R. N. Mohapatra; A. Pérez-Lorenzana

    1999-11-17

    We present a new way to break parity symmetry in left-right symmetric models using boundary conditions on the fields residing in the fifth dimension. We also discuss the connection between the limits on the size of extra dimensions and the scale of right handed symmetry breaking obtained from the analysis of neutrinoless double beta decay in the case where the righthanded gauge symmetry is in the bulk.

  6. siRNA-Like Double-Stranded RNAs Are Specifically Protected Against Degradation in Human Cell Extract

    E-Print Network [OSTI]

    Walter, Nils G.

    -access article distributed under the terms of the Creative Commons Attribution License, which permits are credited. Funding: This work was supported by a Camille Dreyfus Teacher-Scholar award and NIH grant GM

  7. Repair of ultraviolet-light-induced damage

    SciTech Connect (OSTI)

    Sutherland, B.M.

    1981-01-01

    Studies are reviewed which present three major new findings in the photobiology of skin. First, detectable numbers of dimers are formed even at sub-erythymal doses. Second, excision of dimers is much more rapid than would be predicted from results obtained in cell culture. Third, comparison of the rates of excision and photoreactivation in skin indicates that in normal sunlight exposure, photoreactivation may well be the predominant repair pathway in skin. (ACR)

  8. Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress

    SciTech Connect (OSTI)

    Su, Fengtao [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States); Mukherjee, Shibani [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States); Yang, Yanyong [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States); Mori, Eiichiro [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States); Bhattacharya, Souparno [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States); Kobayashi, Junya [Kyoto Univ. (Japan); Yannone, Steven  M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Chen, David  J. [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States); Asaithamby, Aroumougame [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States)

    2014-11-20

    WRN, the protein defective in Werner syndrome (WS), is a multifunctional nuclease involved in DNA damage repair, replication, and genome stability maintenance. It was assumed that the nuclease activities of WRN were critical for these functions. Here, we report a nonenzymatic role for WRN in preserving nascent DNA strands following replication stress. We found that lack of WRN led to shortening of nascent DNA strands after replication stress. Furthermore, we discovered that the exonuclease activity of MRE11 was responsible for the shortening of newly replicated DNA in the absence of WRN. Mechanistically, the N-terminal FHA domain of NBS1 recruits WRN to replication-associated DNA double-stranded breaks to stabilize Rad51 and to limit the nuclease activity of its C-terminal binding partner MRE11. Thus, this previously unrecognized nonenzymatic function of WRN in the stabilization of nascent DNA strands sheds light on the molecular reason for the origin of genome instability in WS individuals.

  9. SNL Researchers Assess Wind Turbine Blade Inspection and Repair...

    Broader source: Energy.gov (indexed) [DOE]

    also inform how blade inspections are conducted at manufacturing facilities and wind farms, thereby improving maintenance and repair procedures for wind turbine blades. SNL is...

  10. Solar Cells, Wound Repair Winning GVC Technologies | ornl.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Solar Cells, Wound Repair Winning GVC Technologies March 26, 2010 Graduate student teams from the University of Arkansas and the University of Maryland earned first place in the...

  11. Protein Bridges DNA Base and Nucleotide Excision Repair Pathways

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bridges DNA Base and Nucleotide Excision Repair Pathways Print Alkyltransferase proteins (AGT) protect cells from the biological effects of DNA damage caused by the addition...

  12. Model Repair Specifications for Low Voltage Induction Motors

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EASA AR100-1998 Recommended Practice For The Repair of Rotating Electrical Apparatus IEEE IEEE Std. 43, Recommended Practice for Testing Insulation Resistance of Rotating...

  13. Winter Break Trip 2014 New York City

    E-Print Network [OSTI]

    Hutcheon, James M.

    Winter Break Trip 2014 New York City Tentative Trip Information December 13-19, 2014 Saturday Park & Ride Service" o These buses are NOT on the New York City Metro system. · Transportation in the City o Buying a New York Metro card is highly encouraged. o Price for a ride is $2.75 o The cost

  14. Viscoplastic dam breaks and the Bostwick consistometer

    E-Print Network [OSTI]

    Balmforth, Neil

    Viscoplastic dam breaks and the Bostwick consistometer N. J. Balmforth, a R. V. Craster, b P'Informazione, Universit`a di Milano, Crema, Italy Abstract We present a theoretical and experimental analysis of the dam the broken dam) that may assist an experimentalist to unravel those dependences. Experiments are conducted

  15. Investigating the Role of Vitamin D and DNA Repair in Influencing Cancer Presentation and Outcomes 

    E-Print Network [OSTI]

    Syed, Moinuddin Mohammed

    2014-09-26

    differences in DNA repair genes exist, which may in turn contribute to underlying differences in DNA repair capacity. These genes with high Fst value represent all six known common DNA repair pathways and DDR response. This supports our hypothesis...

  16. Waste minimization in an autobody repair shop

    SciTech Connect (OSTI)

    Baria, D.N.; Dorland, D.; Bergeron, J.T.

    1994-12-31

    This work was done to document the waste minimization incorporated in a new autobody repair facility in Hermantown, Minnesota. Humes Collision Center incorporated new waste reduction techniques when it expanded its old facilities in 1992 and it was able to achieve the benefits of cost reduction and waste reduction. Humes Collision Center repairs an average of 500 cars annually and is a very small quantity generator (VSQG) of hazardous waste, as defined by the Minnesota Pollution Control Agency (MPCA). The hazardous waste consists of antifreeze, batteries, paint sludge, refrigerants, and used oil, while the nonhazardous waste consists of cardboard, glass, paint filters, plastic, sanding dust, scrap metal, and wastewater. The hazardous and nonhazardous waste output were decreased by 72%. In addition, there was a 63% reduction in the operating costs. The waste minimization includes antifreeze recovery and recycling, reduction in unused waste paint, reduction, recovery and recycle of waste lacquer thinner for cleaning spray guns and paint cups, elimination of used plastic car bags, recovery and recycle of refrigerant, reduction in waste sandpaper and elimination of sanding dust, and elimination of waste paint filters. The rate of return on the investment in waste minimization equipment is estimated from 37% per year for the distillation unit, 80% for vacuum sanding, 146% for computerized paint mixing, 211% for the refrigerant recycler, to 588% per year for the gun washer. The corresponding payback time varies from 3 years to 2 months.

  17. Computational model of aortic valve surgical repair using grafted pericardium

    E-Print Network [OSTI]

    1 Computational model of aortic valve surgical repair using grafted pericardium Peter E. Hammer1, aortic valve repair, membrane, surgical planning, leaflet graft, pericardium ABSTRACT Aortic valve leaflets. Difficulty is largely due to the complex geometry and function of the valve and the lower

  18. Injury and Repair: Retinal Remodeling Robert E. Marc

    E-Print Network [OSTI]

    Marc, Robert E.

    Injury and Repair: Retinal Remodeling Robert E. Marc Department of Ophthalmology John A. Moran Eye Center 65 Mario Capecchi Dr University of Utah Salt Lake City, UT 84132 robert.marc@hsc.utah.edu Keywords photoreceptors In press Elsevier Encyclopedia of the Eye Robert E. Marc :: Chapter 220 :: Injury and Repair

  19. Coherent testing and simulation of composite blade repair 

    E-Print Network [OSTI]

    McNichols, Brian Glenn

    1997-01-01

    The objective of this research program is to experimentally and computationally determine the static and fatigue response for two methods of repair to an E/Glass-Epoxy sandwich laminate. The proposed methods of repair are a scarf and overlap patch...

  20. Simplification and Repair of Polygonal Models Using Volumetric Techniques

    E-Print Network [OSTI]

    Turk, Greg

    data sets. Medical sensing technology such as MRI, CT, and PET scanners produce large volume data sets that are nonmanifold and simplification of models. Repair is the process of taking a model that may have undesirable representation that yields a simple yet effective solution to polygon repair. The same voxelization process

  1. Regulation of endometrial repair and its impact on heavy menstrual bleeding 

    E-Print Network [OSTI]

    Maybin, Jacqueline Ann

    2011-11-25

    Introduction: The human endometrium has a remarkable capacity for efficient cyclical repair following the inflammatory process of menstruation. Defective postmenstrual repair may contribute to the common complaint of ...

  2. LASER ENGINEERED NET SHAPING FOR REPAIR AND HYDROGEN COMPATIBILITY

    SciTech Connect (OSTI)

    Korinko, P.; Adams, T.

    2011-08-05

    A method to repair mismatched or damaged components using Laser Engineered Net Shaping{sup R} (LENS) technology to apply material was investigated for its feasibility for components exposed to hydrogen. The mechanical properties of LENS bulk materials were also tested for hydrogen compatibility. The LENS process was used to repair simulated and actual mismachined components. These sample components were hydrogen charged and burst tested in the as-received, as-damaged, and as-repaired conditions. The testing showed that there was no apparent additional deficiency associated with hydrogen charging compared to the repair technique. The repair techniques resulted in some components meeting the requirements while others did not. Additional procedure/process development is required prior to recommending production use of LENS.

  3. Breaking a Pocket of Resistance in the Fight Against Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Breaking a Pocket of Resistance in the Fight Against Cancer Breaking a Pocket of Resistance in the Fight Against Cancer Print Thursday, 12 December 2013 11:55 ras protein The new...

  4. Assigning phrase breaks from part-of-speech sequences. 

    E-Print Network [OSTI]

    Black, Alan W; Taylor, Paul A

    1997-01-01

    One of the important stages in the process of turning unmarked text into speech is the assignment of appropriate phrase break boundaries. Phrase break boundaries are important to later modules including accent ...

  5. Navy Breaks World Record With Futuristic Free-Electron Laser...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    foxnews.comscitech20110218navy-breaks-world-record-futuristic-laser-getting-real Submitted: Sunday, February 20, 2011...

  6. Collective neutrino oscillations and spontaneous symmetry breaking

    E-Print Network [OSTI]

    Duan, Huaiyu

    2015-01-01

    Neutrino oscillations in a hot and dense astrophysical environment such as a core-collapse supernova pose a challenging, seven-dimensional flavor transport problem. To make the problem even more difficult (and interesting), neutrinos can experience collective oscillations through nonlinear refraction in the dense neutrino medium in this environment. Significant progress has been made in the last decade towards the understanding of collective neutrino oscillations in various simplified neutrino gas models with imposed symmetries and reduced dimensions. However, a series of recent studies seem to have "reset" this progress by showing that these models may not be compatible with collective neutrino oscillations because the latter can break the symmetries spontaneously if they are not imposed. We review some of the key concepts of collective neutrino oscillations by using a few simple toy models. We also elucidate the breaking of spatial and directional symmetries in these models because of collective oscillation...

  7. A Fourth Chiral Generation And Susy Breaking

    E-Print Network [OSTI]

    Akin Wingerter

    2011-05-30

    We revisit four generations within the context of supersymmetry. We compute the perturbativity limits for the fourth generation Yukawa couplings and show that if the masses of the fourth generation lie within reasonable limits of their present experimental lower bounds, it is possible to have perturbativity only up to scales around 1000 TeV, i.e. the current experimental bounds and perturbative unification are mutually exclusive. Such low scales are ideally suited to incorporate gauge mediated supersymmetry breaking, where the mediation scale can be as low as 10-20 TeV. The minimal messenger model, however, is highly constrained. Lack of electroweak symmetry breaking rules out a large part of the parameter space, and in the remaining part, the fourth generation stau is tachyonic.

  8. Symmetry Breaking in Neuroevolution: A Technical Report

    E-Print Network [OSTI]

    Urfalioglu, Onay

    2011-01-01

    Artificial Neural Networks (ANN) comprise important symmetry properties, which can influence the performance of Monte Carlo methods in Neuroevolution. The problem of the symmetries is also known as the competing conventions problem or simply as the permutation problem. In the literature, symmetries are mainly addressed in Genetic Algoritm based approaches. However, investigations in this direction based on other Evolutionary Algorithms (EA) are rare or missing. Furthermore, there are different and contradictionary reports on the efficacy of symmetry breaking. By using a novel viewpoint, we offer a possible explanation for this issue. As a result, we show that a strategy which is invariant to the global optimum can only be successfull on certain problems, whereas it must fail to improve the global convergence on others. We introduce the \\emph{Minimum Global Optimum Proximity} principle as a generalized and adaptive strategy to symmetry breaking, which depends on the location of the global optimum. We apply the...

  9. Textural break foundation wall construction modules

    DOE Patents [OSTI]

    Phillips, Steven J. (Kennewick, WA)

    1990-01-01

    Below-grade, textural-break foundation wall structures are provided for inhibiting diffusion and advection of liquids and gases into and out from a surrounding hydrogeologic environment. The foundation wall structure includes a foundation wall having an interior and exterior surface and a porous medium disposed around a portion of the exterior surface. The structure further includes a modular barrier disposed around a portion of the porous medium. The modular barrier is substantially removable from the hydrogeologic environment.

  10. Using instrument scraper surveys for corrosion repair

    SciTech Connect (OSTI)

    Akhnoukh, S.R.; Baghabrah, M.A. (Aramco (SA))

    1990-07-01

    This paper reports on a program for overall pipe line repair. This program was implemented to maintain pipe line integrity and for identifying problem areas which require reconditioning or replacing by: reviewing pipe line leak history; checking periodically lifetime expectancy and integrity of pipe coatings; using cathodic protection annual survey results to locate low potential areas (close-interval survey is needed to identify the exact location of corrosion); and hydrotesting the pipe line (using leaks or ruptures from the hydrotest to identify problem areas). The pipe line revalidation plan is insufficient for identifying pipe line leaks. Instrumented pig testing provides more accurate and reliable ways of testing the pipe line for internal or external corrosion or defects.

  11. Alternative Breaks Alcohol and Drug Policy 2014-2015

    E-Print Network [OSTI]

    Tipple, Brett

    Alternative Breaks Alcohol and Drug Policy 2014-2015 In order to promote personal development order and stability on Alternative Break trips, the following standards concerning drug and alcohol use have been set and will be enforced on all Alternative Break trips: 1. Use, possession or distribution

  12. Best Management Practices (BMPs) for the Ship and Boat Building and Repair

    E-Print Network [OSTI]

    .................................................................................................................. 1 1.3 PROFILE OF THE B.C. SHIPBUILDING AND REPAIR INDUSTRY

  13. Intermediate hearth repair technique at Thyssen Stahl AG

    SciTech Connect (OSTI)

    Kowalski, W.; Bachhofen, H.J.; Ruether, P.; Ballewski, T. [Thyssen Stahl AG, Duisburg (Germany)

    1996-12-31

    Nowadays various techniques for the fastest possible intermediate repair and/or emplacement of refractory materials above the tuyere level allow a significant extension of furnace campaign life. The latter are hence now exclusively determined by the service life of the hearth. The improvement of hearth monitoring and the estimation of residual brick strength of the refractory lining on the basis of temperature measurements in the hearth enable the location of individual zones of premature wear. These measurement methods, which were developed by Thyssen Stahl AG, aid the decision to undertake selective repair of the hearth. Three areas of repair are differentiated: taphole zone; hearth wall, localized; and hearth wall, extensive. This hearth repair method is described in this report using the example of hearth refurbishing blast furnace 8, Hamborn.

  14. Repair Sequences in American Learners of German Interlanguage

    E-Print Network [OSTI]

    Wisbey, Evelyn

    2010-04-25

    This study in Conversation Analysis investigates the organization of other-initiated repair sequences in American learners of German, i.e., it examines how learners deal with troubles in hearing or understanding that they ...

  15. Extended mechanical stimulations of cartilage for growth and repair

    E-Print Network [OSTI]

    Lee, Gary C. (Gary Chiaray), 1980-

    2004-01-01

    Extended mechanical stimulation of articular cartilage in an in vitro model explant system promotes growth and repair. An alternating day mechanical loading protocol consisting of dynamic sinusoidal compression results in ...

  16. Factories: The Shipbuilding and Ship-repairing Regulations 1960 

    E-Print Network [OSTI]

    Hare, John

    1960-01-01

    These Regulations revoke the Shipbuilding Regulations, 1931, which were designed for the safety, health and welfare of persons employed in the construction and repair of ships in sbipbuilding yards. The present Regulations, ...

  17. Development/Plasticity/Repair Dorsally and Ventrally Derived Oligodendrocytes Have

    E-Print Network [OSTI]

    Richardson, William D.

    Development/Plasticity/Repair Dorsally and Ventrally Derived Oligodendrocytes Have Similar derived oligodendrocyte (OL) lineage cells have different properties. We generated a dual reporter mouse line to color code ventrally and dorsally derived OLPs (vOLPs and d

  18. Acoustic Emission from Breaking Bamboo Chopstick

    E-Print Network [OSTI]

    Sun-Ting Tsai; Panpan Huang; Li-Min Wang; Zhengning Yang; Chin-De Chang; Tzay-Ming Hong

    2015-09-02

    The acoustic emission from breaking a bamboo chopstick or a bundle of spaghetti is found to exhibit similar behavior as the famous seismic laws of Gutenberg-Richter, Omori, and Bath. By use of a force-sensitive detector, we establish a positive correlation between the sound intensity and the magnitude of tremor. We also succeed at deriving these power laws analytically without invoking the concept of phase transition or self-organized criticality. In essence, geometry is more important than mechanics at rendering the statistical behavior of this crackling sound.

  19. Breaking Barriers in Polymer Additive Manufacturing

    SciTech Connect (OSTI)

    Love, Lonnie J; Duty, Chad E; Post, Brian K; Lind, Randall F; Lloyd, Peter D; Kunc, Vlastimil; Peter, William H; Blue, Craig A

    2015-01-01

    Additive Manufacturing (AM) enables the creation of complex structures directly from a computer-aided design (CAD). There are limitations that prevent the technology from realizing its full potential. AM has been criticized for being slow and expensive with limited build size. Oak Ridge National Laboratory (ORNL) has developed a large scale AM system that improves upon each of these areas by more than an order of magnitude. The Big Area Additive Manufacturing (BAAM) system directly converts low cost pellets into a large, three-dimensional part at a rate exceeding 25 kg/h. By breaking these traditional barriers, it is possible for polymer AM to penetrate new manufacturing markets.

  20. Repairs for damaged bolt holes in continuous fiber reinforced plastics 

    E-Print Network [OSTI]

    Copps, Kevin Daniel

    1992-01-01

    of fastened joints and to investigate previous techniques for the repair of continuous fiber reinforced plastics. LITERATURE REVIEW Characterizing Failure Modes There is very little agreement about what conditions constitute failure in composite joints... of possible methods for preventing and repairing fastener hole defects. Proper drilling technique The optimal drilling conditions for fiber reinforced parts are hard to control, and can differ depending on the structural application. The proper technique...

  1. Insulin-Like Growth Factor-Type 1 Receptor Inhibitor NVP-AEW541 Enhances Radiosensitivity of PTEN Wild-Type but Not PTEN-Deficient Human Prostate Cancer Cells

    SciTech Connect (OSTI)

    Isebaert, Sofie F.; Swinnen, Johannes V.; McBride, William H.; Haustermans, Karin M.

    2011-09-01

    Purpose: During the past decade, many clinical trials with both monoclonal antibodies and small molecules that target the insulin-like growth factor-type 1 receptor (IGF-1R) have been launched. Despite the important role of IGF-1R signaling in radioresistance, studies of such agents in combination with radiotherapy are lagging behind. Therefore, the aim of this study was to investigate the effect of the small molecule IGF-1R kinase inhibitor NVP-AEW541 on the intrinsic radioresistance of prostate cancer cells. Methods and Materials: The effect of NVP-AEW541 on cell proliferation, cell viability, IGF-1R signaling, radiosensitivity, cell cycle distribution, and double strand break repair was determined in three human prostate cancer cell lines (PC3, DU145, 22Rv1). Moreover, the importance of the PTEN pathway status was explored by means of transfection experiments with constitutively active Akt or inactive kinase-dead Akt. Results: NVP-AEW541 inhibited cell proliferation and decreased cell viability in a time-and dose-dependent manner in all three cell lines. Radiosensitization was observed in the PTEN wild-type cell lines DU145 and 22Rv1 but not in the PTEN-deficient PC3 cell line. NVP-AEW541-induced radiosensitization coincided with downregulation of phospho-Akt levels and high levels of residual double strand breaks. The importance of PTEN status in the radiosensitization effect was confirmed by transfection experiments with constitutively active Akt or inactive kinase-dead Akt. Conclusions: NVP-AEW541 enhances the effect of ionizing radiation in PTEN wild-type, but not in PTEN-deficient, prostate cancer cells. Proper patient selection based on the PTEN status of the tumor will be critical to the achievement of optimal results in clinical trials in which the combination of radiotherapy and this IGF-1R inhibitor is being explored.

  2. Biochemical characterization of the E. coli Very Short Patch Repair pathway and its coordination with methyltransferase repair of 0?-methylguanine

    E-Print Network [OSTI]

    Rye, Peter Thomas

    2006-01-01

    The E. coli Very Short Patch Repair (VSPR) system corrects T:G mismatches that arise through Dcm-mediated methylation and subsequent deamination of the underlined cytosine residue in the palindromic sequence 5'-CCWGG-3' ...

  3. Chip breaking system for automated machine tool

    DOE Patents [OSTI]

    Arehart, Theodore A. (Clinton, TN); Carey, Donald O. (Oak Ridge, TN)

    1987-01-01

    The invention is a rotary selectively directional valve assembly for use in an automated turret lathe for directing a stream of high pressure liquid machining coolant to the interface of a machine tool and workpiece for breaking up ribbon-shaped chips during the formation thereof so as to inhibit scratching or other marring of the machined surfaces by these ribbon-shaped chips. The valve assembly is provided by a manifold arrangement having a plurality of circumferentially spaced apart ports each coupled to a machine tool. The manifold is rotatable with the turret when the turret is positioned for alignment of a machine tool in a machining relationship with the workpiece. The manifold is connected to a non-rotational header having a single passageway therethrough which conveys the high pressure coolant to only the port in the manifold which is in registry with the tool disposed in a working relationship with the workpiece. To position the machine tools the turret is rotated and one of the tools is placed in a material-removing relationship of the workpiece. The passageway in the header and one of the ports in the manifold arrangement are then automatically aligned to supply the machining coolant to the machine tool workpiece interface for breaking up of the chips as well as cooling the tool and workpiece during the machining operation.

  4. Three-Dimensional Simulations of Deep-Water Breaking Waves

    E-Print Network [OSTI]

    Brucker, Kyle A; Dommermuth, Douglas G; Adams, Paul

    2014-01-01

    The formulation of a canonical deep-water breaking wave problem is introduced, and the results of a set of three-dimensional numerical simulations for deep-water breaking waves are presented. In this paper fully nonlinear progressive waves are generated by applying a normal stress to the free surface. Precise control of the forcing allows for a systematic study of four types of deep-water breaking waves, characterized herein as weak plunging, plunging, strong plunging, and very strong plunging.

  5. Alternative Breaks: A Study on Risk Management and Safety Policies

    E-Print Network [OSTI]

    Ong, Alyssa

    2013-04-01

    74 | JOURNAL OF undergraduate research Alternative Breaks: A Study on Risk Management and Safety Policies Alyssa Ong Safety and liability issues have always been a concern of the Alternative Breaks program at the University of Kansas.... To promote participant safety and to protect the program from litigation, this research was done to gain a deeper understanding of what other University’s Alternative Breaks programs have been doing. This research was done specifically to find out...

  6. Dynamical electroweak symmetry breaking and the top quark

    SciTech Connect (OSTI)

    Chivukula, R.S. [Boston Univ., MA (United States)

    1997-01-01

    In this talk, I discuss theories of dynamical electroweak symmetry breaking, with emphasis on the implications of a heavy top quark on the weak interaction {rho} parameter.

  7. Polymer nanocomposites for high-temperature composite repair

    SciTech Connect (OSTI)

    Sheng, Xia

    2008-12-01

    A novel repair agent for resin-injection repair of advanced high temperature composites was developed and characterized. The repair agent was based on bisphenol E cyanate ester (BECy) and reinforced with alumina nanoparticles. To ensure good dispersion and compatibility with the BECy matrix in nanocomposites, the alumina nanoparticles were functionalized with silanes. The BECy nanocomposites, containing bare and functionalized alumina nanoparticles, were prepared and evaluated for their thermal, mechanical, rheological, and viscoelastic properties. The monomer of BECy has an extremely low viscosity at ambient temperature, which is good for processability. The cured BECy polymer is a highly cross-linked network with excellent thermal mechanical properties, with a high glass transition temperature (T{sub g}) of 270 C and decomposition temperature above 350 C. The incorporation of alumina nanoparticles enhances the mechanical and rheological properties of the BECy nanocomposites. Additionally, the alumina nanoparticles are shown to catalyze the cure of BECy. Characterization of the nanocomposites included dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy. The experimental results show that the BECy nanocomposite is a good candidate as repair agent for resin-injection repair applications.

  8. Wave breaking and setup over fringing reefs Zhenhua Huang

    E-Print Network [OSTI]

    Wave breaking and setup over fringing reefs Zhenhua Huang Principal investigator at Earth Observatory of Singapore Nanyang Technological University Abstract Wave breaking over coral reefs can induce wave setup and near-shore currents, which have significant impacts on near-shore circulations

  9. The hidden X-ray breaks in afterglow light curves

    SciTech Connect (OSTI)

    Curran, P. A.; Wijers, R. A. M. J.; Horst, A. J. van der; Starling, R. L. C.

    2008-05-22

    Gamma-Ray Burst (GRB) afterglow observations in the Swift era have a perceived lack of achromatic jet breaks compared to the BeppoSAX, or pre-Swift era. Specifically, relatively few breaks, consistent with jet breaks, are observed in the X-ray light curves of these bursts. If these breaks are truly missing, it has serious consequences for the interpretation of GRB jet collimation and energy requirements, and the use of GRBs as standard candles.Here we address the issue of X-ray breaks which are possibly 'hidden' and hence the light curves are misinterpreted as being single power-laws. We show how a number of precedents, including GRB 990510 and GRB 060206, exist for such hidden breaks and how, even with the well sampled light curves of the Swift era, these breaks may be left misidentified. We do so by synthesising X-ray light curves and finding general trends via Monte Carlo analysis. Furthermore, in light of these simulations, we discuss how to best identify achromatic breaks in afterglow light curves via multi-wavelength analysis.

  10. The repair and rehabilitation method of Tokyo gas

    SciTech Connect (OSTI)

    Yagi, Shuichi [Tokyo Gas Co., Ltd. (Japan)

    1996-08-01

    It has been an important matter for gas utilities to maintain their pipelines easily and economically. But pipes that have become old suffer from progressive corrosion, and as a result of vibration caused by traffic or the effects of land subsidence, joints can become loosened. To repair pipes that have suffered in such ways, the usual method to do is to dig them up and replace them with new ones. But this method requires a large amount of excavation, so the work takes a long time to complete and is costly. To deal with these problems, Tokyo Gas developed number of repair and rehabilitation methods to permit renewal of pipelines without replacing them. In this paper, I would like to introduce our repair and rehabilitation methods for low-pressure pipeline. 4 refs., 9 figs., 4 tabs.

  11. DNA damage in cells exhibiting radiation-induced genomic instability

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Keszenman, Deborah J.; Kolodiuk, Lucia; Baulch, Janet E.

    2015-02-22

    Cells exhibiting radiation induced genomic instability exhibit varied spectra of genetic and chromosomal aberrations. Even so, oxidative stress remains a common theme in the initiation and/or perpetuation of this phenomenon. Isolated oxidatively modified bases, abasic sites, DNA single strand breaks and clustered DNA damage are induced in normal mammalian cultured cells and tissues due to endogenous reactive oxygen species generated during normal cellular metabolism in an aerobic environment. While sparse DNA damage may be easily repaired, clustered DNA damage may lead to persistent cytotoxic or mutagenic events that can lead to genomic instability. In this study, we tested the hypothesismore »that DNA damage signatures characterised by altered levels of endogenous, potentially mutagenic, types of DNA damage and chromosomal breakage are related to radiation-induced genomic instability and persistent oxidative stress phenotypes observed in the chromosomally unstable progeny of irradiated cells. The measurement of oxypurine, oxypyrimidine and abasic site endogenous DNA damage showed differences in non-double-strand breaks (DSB) clusters among the three of the four unstable clones evaluated as compared to genomically stable clones and the parental cell line. These three unstable clones also had increased levels of DSB clusters. The results of this study demonstrate that each unstable cell line has a unique spectrum of persistent damage and lead us to speculate that alterations in DNA damage signaling and repair may be related to the perpetuation of genomic instability.« less

  12. Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity

    SciTech Connect (OSTI)

    Kothandapani, Anbarasi; Gopalakrishnan, Kathirvel; Kahali, Bhaskar; Reisman, David; Patrick, Steve M.

    2012-10-01

    Chromatin remodeling complex SWI/SNF plays important roles in many cellular processes including transcription, proliferation, differentiation and DNA repair. In this report, we investigated the role of SWI/SNF catalytic subunits Brg1 and Brm in the cellular response to cisplatin in lung cancer and head/neck cancer cells. Stable knockdown of Brg1 and Brm enhanced cellular sensitivity to cisplatin. Repair kinetics of cisplatin DNA adducts revealed that downregulation of Brg1 and Brm impeded the repair of both intrastrand adducts and interstrand crosslinks (ICLs). Cisplatin ICL-induced DNA double strand break repair was also decreased in Brg1 and Brm depleted cells. Altered checkpoint activation with enhanced apoptosis as well as impaired chromatin relaxation was observed in Brg1 and Brm deficient cells. Downregulation of Brg1 and Brm did not affect the recruitment of DNA damage recognition factor XPC to cisplatin DNA lesions, but affected ERCC1 recruitment, which is involved in the later stages of DNA repair. Based on these results, we propose that SWI/SNF chromatin remodeling complex modulates cisplatin cytotoxicity by facilitating efficient repair of the cisplatin DNA lesions. -- Highlights: Black-Right-Pointing-Pointer Stable knockdown of Brg1 and Brm enhances cellular sensitivity to cisplatin. Black-Right-Pointing-Pointer Downregulation of Brg1 and Brm impedes the repair of cisplatin intrastrand adducts and interstrand crosslinks. Black-Right-Pointing-Pointer Brg1 and Brm deficiency results in impaired chromatin relaxation, altered checkpoint activation as well as enhanced apoptosis. Black-Right-Pointing-Pointer Downregulation of Brg1 and Brm affects recruitment of ERCC1, but not XPC to cisplatin DNA lesions.

  13. Mechanisms of radiation-induced neoplastic cell transformation

    SciTech Connect (OSTI)

    Yang, T.C.H.; Tobias, C.A.

    1984-04-01

    Studies with cultured mammalian cells demonstrated clearly that radiation can transform cells directly and can enhance the cell transformation by oncogenic DNA viruses. In general, high-LET heavy-ion radiation can be more effective than X and gamma rays in inducing neoplastic cell transformation. Various experimental results indicate that radiation-induced DNA damage, most likely double-strand breaks, is important for both the initiation of cell transformation and for the enhancement of viral transformation. Some of the transformation and enhancement lesions can be repaired properly in the cell, and the amount of irrepairable lesions produced by a given dose depends on the quality of radiation. An inhibition of repair processes with chemical agents can increase the transformation frequency of cells exposed to radiation and/or oncogenic viruses, suggesting that repair mechanisms may play an important role in the radiation transformation. The progression of radiation-transformed cells appears to be a long and complicated process that can be modulated by some nonmutagenic chemical agents, e.g., DMSO. Normal cells can inhibit the expression of transforming properties of tumorigenic cells through an as yet unknown mechanism. The progression and expression of transformation may involve some epigenetic changes in the irradiated cells. 38 references, 15 figures, 1 table.

  14. Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities

    SciTech Connect (OSTI)

    Langland, Gregory T.; Yannone, Steven M.; Langland, Rachel A.; Nakao, Aki; Guan, Yinghui; Long, Sydney B.T.; Vonguyen, Lien; Chen, David J.; Gray, Joe W; Chen, Fanqing

    2009-09-07

    The variability of radiation responses in ovarian tumors and tumor-derived cell lines is poorly understood. Since both DNA repair capacity and p53 status can significantly alter radiation sensitivity, we evaluated these factors along with radiation sensitivity in a panel of sporadic human ovarian carcinoma cell lines. We observed a gradation of radiation sensitivity among these sixteen lines, with a five-fold difference in the LD50 between the most radiosensitive and the most radioresistant cells. The DNA-dependent protein kinase (DNA-PK) is essential for the repair of radiation induced DNA double-strand breaks in human somatic cells. Therefore, we measured gene copy number, expression levels, protein abundance, genomic copy and kinase activity for DNA-PK in all of our cell lines. While there were detectable differences in DNA-PK between the cell lines, there was no clear correlation with any of these differences and radiation sensitivity. In contrast, p53 function as determined by two independent methods, correlated well with radiation sensitivity, indicating p53 mutant ovarian cancer cells are typically radioresistant relative to p53 wild-type lines. These data suggest that the activity of regulatory molecules such as p53 may be better indicators of radiation sensitivity than DNA repair enzymes such as DNAPK in ovarian cancer.

  15. Ice plug employed on subsea pipeline bend during repair

    SciTech Connect (OSTI)

    1997-12-22

    The first controlled-temperature ice plug in the bend of an offshore gas trunkline has been carried out for Phillips Petroleum Co. Norway on its Norpipe A.S. platform in the German sector of the North Sea. The procedure was part of a subsea valve repair operation. The ice plug was successfully formed offshore and tested to a differential pressure of 1,450 psi. Repair of two valves required only 5 days during which time gas production was operating at close to 50--60% via the platform bypass, says the service company. The paper discusses the procedure.

  16. The cellular role of the specific immune system in fracture repair 

    E-Print Network [OSTI]

    Gaston, Mark S

    2009-01-01

    This thesis embodies a novel investigation into the cellular role of the specific immune system in fracture repair....

  17. Development of quick repairing technique for ceramic burner in hot stove of blast furnace

    SciTech Connect (OSTI)

    Kondo, Atsushi; Doura, Kouji; Nakamura, Hirofumi [Sumitomo Metal Industries, Ltd., Wakayama (Japan). Wakayama Steel Works

    1997-12-31

    Refractories of ceramic burner in hot stoves at Wakayama No. 4 blast furnace were damaged. There are only three hot stoves, so repairing must be done in a short. Therefore, a quick repairing technique for ceramic burners has been developed, and two ceramic burners were repaired in just 48 hours.

  18. Attacking and Repairing the Improved ModOnions Protocol

    E-Print Network [OSTI]

    Borisov, Nikita

    Attacking and Repairing the Improved ModOnions Protocol Nikita Borisov1 , Marek Klonowski2 presented in ACNS 2008. The protocol itself was proposed as an improved version of ModOnions, which uses universal re-encryption in order to avoid replay attacks. How- ever, ModOnions allowed the detour attack

  19. Availability Analysis of Repairable Computer Systems and Stationarity Detection

    E-Print Network [OSTI]

    Sericola, Bruno

    Availability Analysis of Repairable Computer Systems and Stationarity Detection Bruno Sericola computer system and we assume, as usual, that the system is modeled by a finite Markov process. We propose of performability measures. Index TermsÐRepairable computer systems, dependability, availability, performability

  20. Ancient bacteria show evidence of DNA repair Sarah Stewart Johnson*

    E-Print Network [OSTI]

    Nielsen, Rasmus

    Ancient bacteria show evidence of DNA repair Sarah Stewart Johnson* , Martin B. Hebsgaard , Torben for review June 14, 2007) Recent claims of cultivable ancient bacteria within sealed environ- ments highlight-term survival of bacteria sealed in frozen conditions for up to one million years. Our results show evidence

  1. Development/Plasticity/Repair Analogous Synaptic Plasticity Profiles Emerge from

    E-Print Network [OSTI]

    Narayanan, Rishikesh

    Development/Plasticity/Repair Analogous Synaptic Plasticity Profiles Emerge from Disparate Channel Institute of Technology, Calicut 637 601, India, and 3Bio-Medical Technology Wing, Sree Chitra Thirunal Institute for Medical Science & Technology, Trivandrum 695 012, India An open question within

  2. Development/Plasticity/Repair Group I Metabotropic Glutamate Receptors Control

    E-Print Network [OSTI]

    Grau, James

    Development/Plasticity/Repair Group I Metabotropic Glutamate Receptors Control Metaplasticity the spinal cord can support several forms of plasticity, including response­outcome (instrumental) learning. This inhibi- tion of plasticity in spinal learning is itself a form of plasticity that requires i

  3. The Self-Construction and -Repair of a Foraging

    E-Print Network [OSTI]

    Siegelmann , Hava T

    at explicit design of self-constructing and -repairing systems by hierarchical specification of elementary intracellular mechanisms via a kind of genetic code. The interplay between individual cells and the gradually are usually designed and constructed by a process that transforms an explicit, abstract description

  4. Thermosetting Polymer-Matrix Composites for Strucutral Repair Applications

    SciTech Connect (OSTI)

    William Kirby Goertzen

    2007-12-01

    Several classes of thermosetting polymer matrix composites were evaluated for use in structural repair applications. Initial work involved the characterization and evaluation of woven carbon fiber/epoxy matrix composites for structural pipeline repair. Cyanate ester resins were evaluated as a replacement for epoxy in composites for high-temperature pipe repair applications, and as the basis for adhesives for resin infusion repair of high-temperature composite materials. Carbon fiber/cyanate ester matrix composites and fumed silica/cyanate ester nanocomposites were evaluated for their thermal, mechanical, viscoelastic, and rheological properties as they relate to their structure, chemistry, and processing characteristics. The bisphenol E cyanate ester under investigation possesses a high glass transition temperature, excellent mechanical properties, and unique ambient temperature processability. The incorporate of fumed silica served to enhance the mechanical and rheological properties of the polymer and reduce thermal expansion without sacrificing glass transition or drastically altering curing kinetics. Characterization of the composites included dynamic mechanical analysis, thermomechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy.

  5. http://nnr.sagepub.com Neurorehabilitation and Neural Repair

    E-Print Network [OSTI]

    Prochazka, Arthur

    displayed on a computer.The time taken to move to and click on each target was recorded. Results. The use of Neurorehabilitation can be found at:Neurorehabilitation and Neural RepairAdditional services and information for http/2/188Citations at UNIV OF ALBERTA LIBRARY on February 18, 2010http://nnr.sagepub.comDownloaded from #12;Research

  6. Development/Plasticity/Repair Identification of Nicotinic Acetylcholine Receptor Recycling

    E-Print Network [OSTI]

    Alford, Simon

    Development/Plasticity/Repair Identification of Nicotinic Acetylcholine Receptor Recycling and Its plasticity; however, the recycling of receptors has never been observed at peripheral synapses. Using a novel the regulation of receptor density, which could lead to rapid alterations in synaptic efficacy. Key words: toxin

  7. Simplification and Repair of Polygonal Models Using Volumetric Techniques

    E-Print Network [OSTI]

    California at Berkeley, University of

    Simplification and Repair of Polygonal Models Using Volumetric Techniques Fakir S. Nooruddin a method for converting polygonal models to a volumetric representation in a way that handles models by converting a model to and from the volumetric domain. We also describe a new topology-altering simplification

  8. Direct Gauge Mediation of Uplifted Metastable Supersymmetry Breaking in Supergravity

    E-Print Network [OSTI]

    Nobuhito Maru

    2010-08-11

    We propose a direct gauge mediation model based on an uplifted metastable SUSY breaking coupled to supergravity. A constant superpotential plays an essential role to fix the moduli as well as breaking SUSY and R-symmetry and the cancellation of the cosmological constant. Gaugino masses are generated at leading order of SUSY breaking scale, and comparable to the sfermion masses as in the ordinary gauge mediation. Landau pole problem for QCD coupling can be easily solved since more than half of messengers become superheavy, which are heavier than the GUT scale.

  9. Chiral symmetry breaking with no bilinear condensate revisited

    E-Print Network [OSTI]

    Kanazawa, Takuya

    2015-01-01

    While chiral symmetry breaking in the QCD vacuum is attributed to nonzero chiral condensate, an alternative symmetry breaking pattern with no chiral condensate is also possible, as pointed out by Stern. We study the $\\theta$ dependence of this unorthodox phase on the basis of chiral perturbation theory. Physical observables such as energy density, topological susceptibility, non-local chiral order parameter and meson masses are computed analytically in the epsilon-regime. At nonzero $\\theta$ we find an exotic phase that breaks vectorial flavor symmetries in a way analogous to the Aoki phase in lattice QCD.

  10. Petra Nova Project Breaks Ground on World's Largest Post-Combustion...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Petra Nova Project Breaks Ground on World's Largest Post-Combustion Carbon Capture Project Petra Nova Project Breaks Ground on World's Largest Post-Combustion Carbon Capture...

  11. Wave breaking along the stratospheric polar vortex as seen in ERA-40 data

    E-Print Network [OSTI]

    Abatzoglou, John T; Magnusdottir, Gudrun

    2007-01-01

    1983), Breaking planetary waves in the stratosphere, Nature,structure of breaking Rossby waves in the polar wintertimecontrol of upward wave flux near the tropopause, Geophys.

  12. Holographic theories of electroweak symmetry breaking without a Higgs Boson

    E-Print Network [OSTI]

    Burdman, Gustavo; Nomura, Yasunori

    2003-01-01

    Breaking without a Higgs Boson Gustavo Burdman a and1] or theories where the Higgs boson arises as a compositeto build models of a composite Higgs boson [4] and dynamical

  13. LANL breaks ground on key sediment control project

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately 2 million features are up to eight feet high and made of rocks...

  14. Assigning phrase breaks from part-of-speech sequences 

    E-Print Network [OSTI]

    Taylor, Paul; Black, Alan W

    This paper presents an algorithm for automatically assigning phrase breaks to unrestricted text for use in a text-to-speech synthesizer. Text is first converted into a sequence of part-of-speech tags. Next a Markov model ...

  15. Symmetry-Breaking Orbital Anisotropy Observed for Detwinned Ba...

    Office of Scientific and Technical Information (OSTI)

    Observed for Detwinned Ba(Fe (1-X) Co (X) ) (2) As (2) Above the Spin Density Wave Transition Citation Details In-Document Search Title: Symmetry-Breaking Orbital...

  16. BUBBLE ENTRAINMENT AND LIQUID-BUBBLE INTERACTION UNDER UNSTEADY BREAKING

    E-Print Network [OSTI]

    Kirby, James T.

    BUBBLE ENTRAINMENT AND LIQUID-BUBBLE INTERACTION UNDER UNSTEADY BREAKING WAVES BY MORTEZA DERAKHTI Momentum Exchange . . . . . . . . . . . . . . . . . . . . . 11 2.3 Bubble Entrainment Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 4.1 Bubble Entrainment And Transport . . . . . . . . . . . . . . . . . . . 27 4.1.1 3D free

  17. Strength distributions and symmetry breaking in coupled microwave billiards

    E-Print Network [OSTI]

    B. Dietz. T. Guhr; H. L. Harney; A. Richter

    2006-06-14

    Flat microwave cavities can be used to experimentally simulate quantum mechanical systems. By coupling two such cavities, we study the equivalent to the symmetry breaking in quantum mechanics. As the coupling is tunable, we can measure resonance strength distributions as a function of the symmetry breaking. We analyze the data employing a qualitative model based on Random Matrix Theory (RMT) and show that the results derived from the strength distribution are consistent with those previously obtained from spectral statistics.

  18. Lorentz symmetry breaking effects on relativistic EPR correlations

    E-Print Network [OSTI]

    Belich, H; Bakke, K

    2015-01-01

    Lorentz symmetry breaking effects on relativistic EPR (Einstein-Podolsky-Rosen) correlations are discussed. From the modified Maxwell theory coupled to gravity, we establish a possible scenario of the Lorentz symmetry violation and write an effective metric for the Minkowski spacetime. Then, we obtain the Wigner rotation angle via the Fermi-Walker transport of spinors and consider the WKB ((Wentzel-Kramers-Brillouin) approximation in order to study the influence of Lorentz symmetry breaking effects on the relativistic EPR correlations.

  19. Development of a rapid design procedure for emergency repair of bridge columns using fiber-reinforced polymers

    E-Print Network [OSTI]

    Slater, Susan E.

    2008-01-01

    ACI), Building Research Establishment, Ltd. (BRE), Concrete Society and International Concrete Repair Institute jointly publish standards

  20. RARAF Publications This list does not include papers given at scientific meetings unless published in

    E-Print Network [OSTI]

    .L., Meltzer, P., Trent, J.M. and Fornace, Jr, A.J. Differential responses of stress genes to low dose Research Award lecture: Telomeres and Double-strand Breaks ­ All's Well That Ends Well. Radiat. Res. 169: 1, C. and Bond, V.P. Dose- dependence of fast neutron RBE for lens opacification in mice. Radiat. Res

  1. Computational Chemistry DOI: 10.1002/anie.200501671

    E-Print Network [OSTI]

    Simons, Jack

    and Environmental Research, Low Dose Radiation Research Program (M.G.), and the Polish State Committee-energy radiation. Recent experiments suggested that single- and double-strand breaks develop in DNA exposed to low acid bases may be formed by trapping low- energy electrons produced in living cells by high

  2. Testing and evaluation of grout repaired tubular members 

    E-Print Network [OSTI]

    Nunn, John Mansfield

    1992-01-01

    of Failed Weld Seam page 64 65 66 69 73 74 80 82 31 Ideahzed Tubular Dented Member for the Taby, Zhou, and the Parsanejad Methods. . . . . . . . . . . . . . , . 92 32 Dent Geometry for the Elhnas Method 96 33 Experimental Ultimate Capamty vs P... commonly used to repiur damaged tubular members. These include 1 ) welding a sleeve around the outside of the member in the location of the damage, 2 ) applying an externally grouted clamp, and 3 ) applying internal grout Ideally, the repair method...

  3. Providing protection: Agencies receive funding to repair, upgrade dams 

    E-Print Network [OSTI]

    Wythe, Kathy

    2009-01-01

    by Kathy Wythe tx H2O | pg. 26 Providing protection Agencies receive funding to repair, upgrade dams along with local partners, can apply for grant funds, he said. Construction of the dams began through four federal authorizations passed between... 1944 and 1981. Land rights were acquired from landowners, and local agencies constructed the dams with federal money from NRCS (formerly the Soil Conservation Service). Local sponsors?including cities, counties, local soil and water conservation...

  4. ESI/TOF Measurements of a Noncovalent Complex between Lactose Repressor Protein (LacI) and Double-Stranded DNA Containing its Specific Operator Sequence

    E-Print Network [OSTI]

    Ens, Werner

    M buffer solution. Initial attempts to observe the protein tetramer were unsuccessful (as in the case rather broad peaks for both dimer and tetramer. The tetramer appears in two separate envelopes, suggesting that the the charge states 20 to 22 between m/z 7000 and 8000 represent the native tetramer

  5. Monosporascus root rot/vine decline: a study of double-stranded (DS) RNA and its role in the pathogenesis of Monosporascus cannonballus on muskmelon 

    E-Print Network [OSTI]

    Batten, Jeffrey Samuel

    1997-01-01

    dsRNA banding patterns, (Az9O-33-, Tx93-449+, Ca9l-17"+, Tx93-529+, and Tx93-314+'-) were examined in repeated greenhouse pathogenicity trials from 1995 to 1996 to determine if a specific set of dsRNA fragments were associated with hypovirulence and...

  6. Symmetry Breaking and the Geometry of Reduced Density Matrices

    E-Print Network [OSTI]

    V. Zauner; D. Draxler; Y. Lee; L. Vanderstraeten; J. Haegeman; F. Verstraete

    2015-03-03

    The concept of symmetry breaking and the emergence of corresponding local order parameters constitute the pillars of modern day many body physics. The theory of quantum entanglement is currently leading to a paradigm shift in understanding quantum correlations in many body systems and in this work we show how symmetry breaking can be understood from this wavefunction centered point of view. We demonstrate that the existence of symmetry breaking is a consequence of the geometric structure of the convex set of reduced density matrices of all possible many body wavefunctions. The surfaces of those convex bodies exhibit non-analytic behavior in the form of ruled surfaces, which turn out to be the defining signatures for the emergence of symmetry breaking and of an associated order parameter. We illustrate this by plotting the convex sets arising in the context of three paradigmatic examples of many body systems exhibiting symmetry breaking: the quantum Ising model in transverse magnetic field, exhibiting a second order quantum phase transition; the classical Ising model at finite temperature in two dimensions, which orders below a critical temperature $T_c$; and a system of free bosons at finite temperature in three dimensions, exhibiting the phenomenon of Bose-Einstein condensation together with an associated order parameter $\\langle\\psi\\rangle$. Remarkably, these convex sets look all very much alike. We believe that this wavefunction based way of looking at phase transitions demystifies the emergence of order parameters and provides a unique novel tool for studying exotic quantum phenomena.

  7. Breaking anchored droplets in a microfluidic Hele-Shaw cell

    E-Print Network [OSTI]

    Amselem, Gabriel; Gallaire, François; Baroud, Charles N

    2015-01-01

    We study microfluidic self digitization in Hele-Shaw cells using pancake droplets anchored to surface tension traps. We show that above a critical flow rate, large anchored droplets break up to form two daughter droplets, one of which remains in the anchor. Below the critical flow velocity for breakup the shape of the anchored drop is given by an elastica equation that depends on the capillary number of the outer fluid. As the velocity crosses the critical value, the equation stops admitting a solution that satisfies the boundary conditions; the drop breaks up in spite of the neck still having finite width. A similar breaking event also takes place between the holes of an array of anchors, which we use to produce a 2D array of stationary drops in situ.

  8. Break modeling for RELAP5 analyses of ISP-27 Bethsy

    SciTech Connect (OSTI)

    Petelin, S.; Gortnar, O.; Mavko, B.; Parzer, I.

    1992-01-01

    This paper presents pre- and posttest analyses of International Standard Problem (ISP) 27 on the Bethsy facility and separate RELAP5 break model tests considering the measured boundary condition at break inlet. This contribution also demonstrates modifications which have assured the significant improvement of model response in posttest simulations. Calculations were performed using the RELAP5/MOD2/36.05 and RELAP5/MOD3.5M5 codes on the MicroVAX, SUN, and CONVEX computers. Bethsy is an integral test facility that simulates a typical 900-MW (electric) Framatome pressurized water reactor. The ISP-27 scenario involves a 2-in. cold-leg break without HPSI and with delayed operator procedures for secondary system depressurization.

  9. Lorentz symmetry breaking as a quantum field theory regulator

    E-Print Network [OSTI]

    Visser, Matt

    2009-01-01

    Perturbative expansions of relativistic quantum field theories typically contain ultraviolet divergences requiring regularization and renormalization. Many different regularization techniques have been developed over the years, but most regularizations require severe mutilation of the logical foundations of the theory. In contrast, breaking Lorentz invariance, while it is certainly a radical step, at least does not damage the logical foundations of the theory. We shall explore the features of a Lorentz symmetry breaking regulator in a simple polynomial scalar field theory, and discuss its implications. We shall quantify just "how much" Lorentz symmetry breaking is required to fully regulate the theory and render it finite. This scalar field theory provides a simple way of understanding many of the key features of Horava's recent article [arXiv:0901.3775 [hep-th

  10. Application of break preclusion concept in German nuclear power plants

    SciTech Connect (OSTI)

    Roos, E. [Energie-Versorgung Schwaben AG, Stuttgart (Germany); Maier, V. [Bayernwerk AG, Muenchen (Germany); Nagel, G. [PraussenElektra AG, Hannover (Germany)] [and others

    1997-04-01

    The break preclusion concept is based on {open_quotes}KTA rules{close_quotes}, {open_quotes}RSK guidelines{close_quotes} and {open_quotes}Rahmenspeziflkation Basissicherheit{close_quotes}. These fundamental rules containing for example requirements on material, design, calculation, manufacturing and testing procedures are explained and the technical realisation is shown by means of examples. The proof of the quality of these piping systems can be executed by means of fracture mechanics calculations by showing that in every case the leakage monitoring system already detect cracks which are clearly smaller than the critical crack. Thus the leak before break behavior and the break preclusion concept is implicitly affirmed. In order to further diminish conservativities in the fracture mechanics procedures, specific research projects are executed which are explained in this contribution.

  11. Slamming of a breaking wave on a wall

    E-Print Network [OSTI]

    Shu, Jian-Jun

    2014-01-01

    This paper is intended to study impact forces of breaking waves on a rigid wall based on a nonlinear potential-flow theory. This is a model problem for some technologically important design issues such as the impact of breaking waves on ships, coastal and offshore structures. We are interested in the short-time successive triggering of nonlinear effects using a small-time expansion. The analytical solutions for the impact force on a rigid wall and the free-surface profile are derived.

  12. WPN 12-9: Weatherization Assistance Program Incidental Repair Measure Guidance

    Broader source: Energy.gov [DOE]

    To provide guidance on incidental repair measures (IRM) allowable under the U.S. Department of Energy Weatherization Assistance Program (WAP).

  13. adaptation of DNA repair Byrne, Rose T; Klingele, Audrey J; Cabot...

    Office of Scientific and Technical Information (OSTI)

    Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair Byrne, Rose T; Klingele, Audrey J; Cabot, Eric L; Schackwitz, Wendy S; Martin, Jeffrey A;...

  14. Brain necrosis after fractionated radiation therapy: Is the halftime for repair longer than we thought?

    SciTech Connect (OSTI)

    Bender, Edward T.

    2012-11-15

    Purpose: To derive a radiobiological model that enables the estimation of brain necrosis and spinal cord myelopathy rates for a variety of fractionation schemes, and to compare repair effects between brain and spinal cord. Methods: Sigmoidal dose response relationships for brain radiation necrosis and spinal cord myelopathy are derived from clinical data using nonlinear regression. Three different repair models are considered and the repair halftimes are included as regression parameters. Results: For radiation necrosis, a repair halftime of 38.1 (range 6.9-76) h is found with monoexponential repair, while for spinal cord myelopathy, a repair halftime of 4.1 (range 0-8) h is found. The best-fit alpha beta ratio is 0.96 (range 0.24-1.73)Conclusions: A radiobiological model that includes repair corrections can describe the clinical data for a variety of fraction sizes, fractionation schedules, and total doses. Modeling suggests a relatively long repair halftime for brain necrosis. This study suggests that the repair halftime for late radiation effects in the brain may be longer than is currently thought. If confirmed in future studies, this may lead to a re-evaluation of radiation fractionation schedules for some CNS diseases, particularly for those diseases where fractionated stereotactic radiation therapy is used.

  15. Development/Plasticity/Repair Identification of Modulators of Hair Cell Regeneration in the

    E-Print Network [OSTI]

    Rubel, Edwin

    Development/Plasticity/Repair Identification of Modulators of Hair Cell Regeneration levels, environmental toxins, and some medications can readily induce damage or loss of hair cells, often

  16. Development/Plasticity/Repair Glycine Transporter-1 Inhibition Promotes Striatal Axon

    E-Print Network [OSTI]

    Sulzer, David

    Development/Plasticity/Repair Glycine Transporter-1 Inhibition Promotes Striatal Axon Sprouting via injections of the toxin 6-hydroxydopamine. We used apharmacologicalapproachtoenhance

  17. Induction and Persistence of Large ?H2AX Foci by High Linear Energy Transfer Radiation in DNA-Dependent protein kinase–Deficient Cells

    SciTech Connect (OSTI)

    Bracalente, Candelaria; Ibañez, Irene L.; Molinari, Beatriz; Palmieri, Mónica; Kreiner, Andrés; Valda, Alejandro; and others

    2013-11-15

    Purpose: To evaluate the cell response to DNA double-strand breaks induced by low and high linear energy transfer (LET) radiations when the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), an essential protein of the nonhomologous end-joining repair pathway, lacks kinase activity. Methods and Materials: CHO10B2, a Chinese hamster ovary cell line, and its derived radiosensitive mutant cell line, irs-20, lacking DNA-PKcs activity, were evaluated after 0 to 3 Gy of ?-rays, plateau and Bragg peak protons, and lithium beams by clonogenic assay, and as a measurement of double-strand breaks, phosphorylated H2AX (?H2AX) foci number and size were quantified by immunocytofluorescence. Results: Irs-20 exhibited greater radiosensitivity and a higher amount of ?H2AX foci than CHO10B2 at 6 hours after irradiation for all types of radiations. Remarkably, CHO10B2 and irs-20 maintained their difference in radiosensitivity after high-LET radiation. Six hours after low-LET radiations, irs-20 did not reach basal levels of ?H2AX at high doses, whereas CHO10B2 recovered basal levels for all doses. After high-LET radiation, only CHO10B2 exhibited a reduction in ?H2AX foci, but it never reached basal levels. Persistent foci in irs-20 confirmed a repair deficiency. Interestingly, after 30 minutes of high-LET radiation both cell lines exhibited large foci (size >0.9 ?m{sup 2}) related to the damage nature, whereas at 6 hours irs-20 showed a higher amount of large foci than CHO10B2, with a 7-fold increase at 3 Gy, that could also be associated to radiosensitivity. Conclusions: We demonstrated, for the first time, an association between deficient DNA-PKcs activity and not only high levels of H2AX phosphorylation but also persistence and size increase of ?H2AX foci after high-LET irradiation.

  18. Blade reliability collaborative : collection of defect, damage and repair data.

    SciTech Connect (OSTI)

    Ashwill, Thomas D.; Ogilvie, Alistair B.; Paquette, Joshua A.

    2013-04-01

    The Blade Reliability Collaborative (BRC) was started by the Wind Energy Technologies Department of Sandia National Laboratories and DOE in 2010 with the goal of gaining insight into planned and unplanned O&M issues associated with wind turbine blades. A significant part of BRC is the Blade Defect, Damage and Repair Survey task, which will gather data from blade manufacturers, service companies, operators and prior studies to determine details about the largest sources of blade unreliability. This report summarizes the initial findings from this work.

  19. The rebuilding and repairing of electric motors and generators

    E-Print Network [OSTI]

    Ridenour, Roy Everett

    1918-01-01

    Motor After Coils had been Put Back in Place In the repairing and rebuilding of electric motors and generators there are three principal factors which must be considered. These factors are, service, cost and reliability. If a machine can easily... motor. This motor had been through a fire in a Cripple Creek mine. The insulation had been burned from the coils except in the slots where mica had been used. The solder was*melted from the rotor and the babbitt from the bearings. Water had been...

  20. DISS. ETH NO. 19459 Synchronization and Symmetry Breaking

    E-Print Network [OSTI]

    Waldmann, Uwe

    DISS. ETH NO. 19459 Synchronization and Symmetry Breaking in Distributed Systems A dissertation of the system's resources becomes a fascinating and challenging task. This dissertation treats of several such coordination problems arising in distributed systems. In the clock synchronization problem, devices carry

  1. Winter Break Trip 2014 New York City & Washington DC

    E-Print Network [OSTI]

    Hutcheon, James M.

    Winter Break Trip 2014 New York City & Washington DC Tentative Trip Information December 13/Meadowlands 575 Park Plaza Drive Secaucus, NJ 07094 (201) 422-9480 Hotel is located 3 miles west of New York City for departure at 5pm. · Public Transportation to and from the city o Bus stop is at NW E ST & NW New Jersey Ave

  2. How does a thermal binary crystal break under shear?

    E-Print Network [OSTI]

    Tobias Horn; Hartmut Löwen

    2014-11-21

    When exposed to strong shearing, the particles in a crystal will rearrange and ultimately, the crystal will break by forming large nonaffine defects. Even for the initial stage of this process, only little effort has been devoted to the understanding of the breaking process on the scale of the individual particle size for thermalized mixed crystals. Here, we explore the shear-induced breaking for an equimolar two-dimensional binary model crystal with a high interaction asymmetry between the two different species such that the initial crystal has an intersecting square sublattice of the two constituents. Using Brownian dynamics computer simulations, we show that the combination of shear and thermal fluctuations leads to a characteristic hierarchical breaking scenario where initially, the more strongly coupled particles are thermally distorted, paving the way for the weakly coupled particles to escape from their cage. This in turn leads to mobile defects which may finally merge, proliferating a cascade of defects, which triggers the final breakage of the crystal. This scenario is in marked contrast to the breakage of one-component crystals close to melting. Moreover, we explore the orientational dependence of the initial shear direction relative to the crystal orientation and compare this to the usual melting scenario without shear. Our results are verifiable in real-space experiments of superparamagnetic colloidal mixtures at a pending air-water interface in an external magnetic field where the shear can be induced by an external laser field.

  3. Static potential from spontaneous breaking of scale symmetry

    E-Print Network [OSTI]

    Patricio Gaete; Eduardo Guendelman; Euro Spallucci

    2007-04-11

    We determine the static potential for a heavy quark-antiquark pair from the spontaneous symmetry breaking of scale invariance in a non-Abelian gauge theory. Our calculation is done within the framework of the gauge-invariant, path-dependent, variables formalism. The result satisfies the 't Hooft basic criterion for achieving confinement.

  4. Towards breaking temperature equilibrium in multi-component Eulerian schemes

    SciTech Connect (OSTI)

    Grove, John W [Los Alamos National Laboratory; Masser, Thomas [Los Alamos National Laboratory

    2009-01-01

    We investigate the effects ofthermal equilibrium on hydrodynamic flows and describe models for breaking the assumption ofa single temperature for a mixture of components in a cell. A computational study comparing pressure-temperature equilibrium simulations of two dimensional implosions with explicit front tracking is described as well as implementation and J-D calculations for non-equilibrium temperature methods.

  5. The far-UV break in quasar energy distributions: dust?

    E-Print Network [OSTI]

    L. Binette; Y. Krongold; S. Haro-Corzo; A. Andersen

    2006-11-01

    A prominent continuum steepening is observed in quasar energy distributions near 1100A. We review possible interpretations for the origin of the so-called far-UV break, putting emphasis on those that favor the emergence of an upturn in the extreme-UV.

  6. Monochromatic and random wave breaking at blocking points

    E-Print Network [OSTI]

    Kirby, James T.

    ; published 4 July 2002. [1] In this paper we study the energy dissipation due to current-limited waveMonochromatic and random wave breaking at blocking points Arun Chawla Center for Coastal and Land and Technology, Portland, Oregon, USA James T. Kirby Center for Applied Coastal Research, University of Delaware

  7. Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research

    E-Print Network [OSTI]

    Nagel, Zachary D.

    Why does a constant barrage of DNA damage lead to disease in some individuals, while others remain healthy? This article surveys current work addressing the implications of inter-individual variation in DNA repair capacity ...

  8. A Lightweight Network Repair Scheme for Data Collection Applications in ZigBee WSNs

    E-Print Network [OSTI]

    Tseng, Yu-Chee

    1 A Lightweight Network Repair Scheme for Data Collection Applications in ZigBee WSNs Meng networks (WSNs). In [4], a quick convergecast solution is proposed for data collection in a ZigBee beacon-enabled tree- based WSN. However, it does not consider the network repair issue. When a ZigBee router loses its

  9. On the Design of an Interactive, Patient-Specific Surgical Simulator for Mitral Valve Repair

    E-Print Network [OSTI]

    On the Design of an Interactive, Patient-Specific Surgical Simulator for Mitral Valve Repair Neil A repair of the mitral valve is a difficult procedure that is often avoided in favor of less effective valve replacement because of the associated technical challenges facing non-expert surgeons

  10. Cooperative Repair with Minimum-Storage Regenerating Codes for Distributed Storage

    E-Print Network [OSTI]

    Li, Baochun

    Cooperative Repair with Minimum-Storage Regenerating Codes for Distributed Storage Jun Li, Baochun--Distributed storage systems store redundant data to tolerate failures of storage nodes and lost data should be repaired when storage nodes fail. A class of MDS codes, called minimum- storage regenerating (MSR) codes

  11. Bridge Damage and Repair Costs from Hurricane Katrina Jamie Padgett1

    E-Print Network [OSTI]

    Padgett, Jamie Ellen

    Bridge Damage and Repair Costs from Hurricane Katrina Jamie Padgett1 ; Reginald DesRoches2 ; Bryant to repair or replace the bridges damaged during the hurricane is estimated at over $1 billion. This paper describes the observed damage patterns to bridges, including damage attributed to storm surge, wind, impact

  12. A Systematic Study of Automated Program Repair: Fixing 55 out of 105 Bugs for $8 Each

    E-Print Network [OSTI]

    New Mexico, University of

    maintenance, which consumes a daunting fraction of the total cost of software production [1]. AutomatedA Systematic Study of Automated Program Repair: Fixing 55 out of 105 Bugs for $8 Each Claire Le-source programs totaling 5.1 million lines of code and involving 10,193 test cases. GenProg automatically repairs

  13. Best Management Practices (BMPs) for Ship and Boat Building and Repair

    E-Print Network [OSTI]

    document for major British Columbia shipbuilding and repair facilities, Environment Canada has conducted a survey of existing practices at all shipbuilding facilities in B.C. (Peter Hatfield, 1993). These survey to the shipbuilding and repair industry. Many of the recommended practices are equally applicable to many other

  14. Quantitative imaging of the air-water flow fields formed by unsteady breaking waves

    E-Print Network [OSTI]

    Belden, Jesse (Jesse Levi)

    2009-01-01

    An experimental method for simultaneously measuring the velocity fields on the air and water side of unsteady breaking waves is presented. The method is applied to breaking waves to investigate the physics of the air and ...

  15. U.S. Department of Energy Breaks Ground on State-of-the-Art Wind...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    U.S. Department of Energy Breaks Ground on State-of-the-Art Wind Turbine Test Facility U.S. Department of Energy Breaks Ground on State-of-the-Art Wind Turbine Test Facility...

  16. Three dimensional effects in analysis of PWR steam line break accident

    E-Print Network [OSTI]

    Tsai, Chon-Kwo

    A steam line break accident is one of the possible severe abnormal transients in a pressurized water reactor. It is required to present an analysis of a steam line break accident in the Final Safety Analysis Report (FSAR) ...

  17. Coastal Wave Generation and Wave Breaking over Terrain: Two Problems in Mesoscale Wave Dynamics 

    E-Print Network [OSTI]

    Qian, Tingting

    2010-07-14

    Two problems in mesoscale wave dynamics are addressed: (i) wave-turbulence interaction in a breaking mountain wave and (ii) gravity wave generation associated with coastal heating gradients. The mean and turbulent structures in a breaking mountain...

  18. Breaking Up (Hydrogen) No Longer As Hard To Do | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Breaking Up (Hydrogen) No Longer As Hard To Do Breaking Up (Hydrogen) No Longer As Hard To Do December 29, 2011 - 1:12pm Addthis Researchers at Argonne National Lab have recently...

  19. Experimental investigation of small-scale breaking waves : flow visualization across the air-water interface

    E-Print Network [OSTI]

    McDonald, Angus Kai

    2005-01-01

    The dynamics of breaking waves significantly affect air-sea fluxes of heat, momentum, mass and energy across the ocean interface. Breaking waves also contribute considerable loading to offshore and coastal structures, and ...

  20. Navier-Stokes simulations of steep breaking water waves with a coupled air-water interface

    E-Print Network [OSTI]

    Hendrickson, Kelli L

    2005-01-01

    Wave breaking on the ocean surface significantly facilitates the transfer of mass, momentum, heat and energy across the air-sea interface. In the context of the near field flow about a surface ship, the breaking bow wave ...

  1. Proposal to negotiate an amendment to an existing blanket contract for the repair, recondioning or replacement of klystrons

    E-Print Network [OSTI]

    2012-01-01

    Proposal to negotiate an amendment to an existing blanket contract for the repair, recondioning or replacement of klystrons

  2. Garcinol, a Histone Acetyltransferase Inhibitor, Radiosensitizes Cancer Cells by Inhibiting Non-Homologous End Joining

    SciTech Connect (OSTI)

    Oike, Takahiro; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo; Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma ; Ogiwara, Hideaki; Torikai, Kohta; Nakano, Takashi; Yokota, Jun; Kohno, Takashi

    2012-11-01

    Purpose: Non-homologous end joining (NHEJ), a major pathway used to repair DNA double-strand breaks (DSBs) generated by ionizing radiation (IR), requires chromatin remodeling at DSB sites through the acetylation of histones by histone acetyltransferases (HATs). However, the effect of compounds with HAT inhibitory activities on the DNA damage response (DDR), including the NHEJ and cell cycle checkpoint, as well as on the radiosensitivity of cancer cells, remains largely unclear. Here, we investigated whether garcinol, a HAT inhibitor found in the rinds of Garcinia indica fruit (called mangosteens), has effects on DDR, and whether it can be used for radiosensitization. Methods and Materials: The following assays were used to examine the effect of garcinol on the inhibition of DSB repair, including the following: a conventional neutral comet assay; a cell-based assay recently developed by us, in which NHEJ repair of DSBs on chromosomal DNA was evaluated; the micrococcal nuclease sensitivity assay; and immunoblotting for autophosphorylation of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). We assessed the effect of garcinol on the cell cycle checkpoint after IR treatment by analyzing the phosphorylation levels of checkpoint kinases CHK1 and CHK2 and histone H3, and by cell cycle profile analysis using flow cytometry. The radiosensitizing effect of garcinol was assessed by a clonogenic survival assay, whereas its effects on apoptosis and senescence were examined by annexin V and senescence-associated {beta}-galactosidase (SA-{beta}-Gal) staining, respectively. Results: We found that garcinol inhibits DSB repair, including NHEJ, without affecting cell cycle checkpoint. Garcinol radiosensitized A549 lung and HeLa cervical carcinoma cells with dose enhancement ratios (at 10% surviving fraction) of 1.6 and 1.5, respectively. Cellular senescence induced by IR was enhanced by garcinol. Conclusion: These results suggest that garcinol is a radiosensitizer that inhibits NHEJ and facilitates senescence without impairing activation of the cell cycle checkpoint.

  3. The Environmental Impact of Lyman-break Galaxies

    E-Print Network [OSTI]

    Elizabeth J. Tasker; Greg L. Bryan

    2006-04-11

    We perform cosmological simulations of galaxies forming at z=3 using the hydrodynamics grid code, Enzo. By selecting the largest galaxies in the volume to correspond to Lyman-break galaxies, we construct observational spectra of the HI flux distribution around these objects, as well as column densities of CIV and OVI throughout a refined region. We successfully reproduce the most recent observations of the mean HI flux in the close vicinity of Lyman-break galaxies but see no evidence for the proximity effect in earlier observations. While our galaxies do return metals to the IGM, their quantity and volume appears to be somewhat less than observed. We conclude that either we do not adequately resolve galactic winds, or that at least some of the intergalactic metal enrichment is by early epoch objects whose mass is smaller than our minimum resolved halo mass.

  4. Nanodiamond dust and the far-ultraviolet quasar break

    E-Print Network [OSTI]

    Binette, L; Morisset, C; Haro-Corzo, S; De Diego, J A; Mutschke, H; Andersen, A C

    2005-01-01

    We explore the possibility that the steepening observed shortward of 1000A in the energy distribution of quasars may result from absorption by dust, being either intrinsic to the quasar environment or intergalactic. We find that a dust extinction curve consisting of nanodiamonds, composed of terrestrial cubic diamonds or with surface impurities as found in carbonaceous chondrite meteorites, such as Allende, is successful in reproducing the sharp break observed. The intergalactic dust model is partially successful in explaining the shape of the composite energy distribution, but must be discarded in the end, as the amount of crystalline dust required is unreasonable and would imply an improbable fine tuning among the dust formation processes. The alternative intrinsic dust model requires a mixture of both cubic diamonds and Allende nanodiamonds and provide a better fit of the UV break. The gas column densities implied are of the order 10^{20} cm^{-2} assuming solar metallicity for carbon and full depletion of ...

  5. Breaking discrete symmetries in the effective field theory of inflation

    E-Print Network [OSTI]

    Dario Cannone; Jinn-Ouk Gong; Gianmassimo Tasinato

    2015-05-29

    We study the phenomenon of discrete symmetry breaking during the inflationary epoch, using a model-independent approach based on the effective field theory of inflation. We work in a context where both time reparameterization symmetry and spatial diffeomorphism invariance can be broken during inflation. We determine the leading derivative operators in the quadratic action for fluctuations that break parity and time-reversal. Within suitable approximations, we study their consequences for the dynamics of linearized fluctuations. Both in the scalar and tensor sectors, we show that such operators can lead to new direction-dependent phases for the modes involved. They do not affect the power spectra, but can have consequences for higher correlation functions. Moreover, a small quadrupole contribution to the sound speed can be generated.

  6. Spectral breaks of Alfvenic turbulence in a collisionless plasma

    E-Print Network [OSTI]

    Boldyrev, Stanislav; Xia, Qian; Zhdankin, Vladimir

    2015-01-01

    Recent observations reveal that magnetic turbulence in the nearly colisionless solar wind plasma extends to scales smaller than the plasma microscales, such as ion gyroradius and ion inertial length. Measured breaks in the spectra of magnetic and density fluctuations at high frequencies are thought to be related to the transition from large-scale hydromagnetic to small-scale kinetic turbulence. The scales of such transitions and the responsible physical mechanisms are not well understood however. In the present work we emphasize the crucial role of the plasma parameters in the transition to kinetic turbulence, such as the ion and electron plasma beta, the electron to ion temperature ratio, the degree of obliquity of turbulent fluctuations. We then propose an explanation for the spectral breaks reported in recent observations.

  7. Experimental evidence of replica symmetry breaking in random lasers

    E-Print Network [OSTI]

    Ghofraniha, N; Di Maria, F; Barbarella, G; Gigli, G; Leuzzi, L; Conti, C

    2014-01-01

    Spin-glass theory is one of the leading paradigms of complex physics and describes condensed matter, neural networks and biological systems, ultracold atoms, random photonics, and many other research fields. According to this theory, identical systems under identical conditions may reach different states and provide different values for observable quantities. This effect is known as Replica Symmetry Breaking and is revealed by the shape of the probability distribution function of an order parameter named the Parisi overlap. However, a direct experimental evidence in any field of research is still missing. Here we investigate pulse-to-pulse fluctuations in random lasers, we introduce and measure the analogue of the Parisi overlap in independent experimental realizations of the same disordered sample, and we find that the distribution function yields evidence of a transition to a glassy light phase compatible with a replica symmetry breaking.

  8. Quantum Walk Search with Time-Reversal Symmetry Breaking

    E-Print Network [OSTI]

    Thomas G. Wong

    2015-07-15

    We formulate Grover's unstructured search algorithm as a chiral quantum walk, where transitioning in one direction has a phase conjugate to transitioning in the opposite direction. For small phases, this breaking of time-reversal symmetry is too small to significantly affect the evolution: the system still approximately evolves in its ground and first excited states, rotating to the marked vertex in time $\\pi \\sqrt{N} / 2$. Increasing the phase does not change the runtime, but rather changes the support for the 2D subspace, so the system evolves in its first and second excited states, or its second and third excited states, and so forth. Apart from the critical phases corresponding to these transitions in the support, which become more frequent as the phase grows, this reveals that our model of quantum search is robust against time-reversal symmetry breaking.

  9. $\\mathcal{PT}$-Symmetry-Breaking Chaos in Optomechanics

    E-Print Network [OSTI]

    Lü, Xin-You; Ma, Jin-Yong; Wu, Ying

    2015-01-01

    We demonstrate a $\\mathcal{PT}$-symmetry-breaking chaos in optomechanical system (OMS), which features an ultralow driving threshold. In principle, this chaos will emerge once a driving laser is applied to the cavity mode and lasts for a period of time. The driving strength is inversely proportional to the starting time of chaos. This originally comes from the dynamical enhancement of nonlinearity by field localization in $\\mathcal{PT}$-symmetry-breaking phase ($\\mathcal{PT}$BP). Moreover, this chaos is switchable by tuning the system parameters so that a $\\mathcal{PT}$-symmetry phase transition occurs. This work may fundamentally broaden the regimes of cavity optomechanics and nonlinear optics. It offers the prospect of exploring ultralow-power-laser triggered chaos and its potential applications in secret communication.

  10. RaDON --Repair and Diagnosis in Ontology Networks Qiu Ji, Peter Haase, Guilin Qi, Pascal Hitzler, Steffen Stadtmuller

    E-Print Network [OSTI]

    Hitzler, Pascal

    RaDON -- Repair and Diagnosis in Ontology Networks Qiu Ji, Peter Haase, Guilin Qi, Pascal Hitzler by integrating multiple distributed ontologies. Our RaDON system pro- vides functionalities to repair ontologies. To meet the above mentioned needs, we develop the RaDON system to repair and diagnose not only

  11. Sequestered uplifting and the pattern of soft supersymmetry breaking terms

    E-Print Network [OSTI]

    Kwang Sik Jeong

    2007-12-17

    We examine the pattern of soft supersymmetry breaking terms in moduli stabilization, where an uplifting potential is provided by spontaneously broken supersymmetry in a generic sequestered sector. From stationary conditions, we derive the relation between moduli F-term vacuum expectation values which does not depend on the details of sequestered uplifting. This moduli F-term relation is crucial for identifying the dominant source of soft terms of visible fields.

  12. Electroweak symmetry breaking by strong dynamics and the collider phenomenology

    SciTech Connect (OSTI)

    Timothy L. Barklow et al.

    2002-12-23

    We discuss the possible signatures in the electroweak symmetry breaking sector by new strong dynamics at future hadron colliders such as the Tevatron upgrade, the LHC and VLHC, and e{sup +}e{sup -} linear colliders. Examples include a heavy Higgs-like scalar resonance, a heavy Technicolor-like vector resonance and pseudo-Goldstone states, non-resonance signatures via enhanced gauge-boson scattering and fermion compositeness.

  13. Statistical estimation of water distribution system pipe break risk 

    E-Print Network [OSTI]

    Yamijala, Shridhar

    2009-05-15

    of support or bedding. 5) Soil movement: Subsidence due to mining, filled land etc. Differential consolidation or geological changes. Changes in water table or soil moisture content. Extremes of climate such as frost heave or clay shrinkage. Loss....021 and 0.014 for pit cast iron and sandspun cast iron pipes respectively, when they employed a similar modeling approach on other datasets. 16 The Shamir and Howard models are one of the first attempts to statistically analyze break records...

  14. Finsler-like structures from Lorentz-breaking classical particles

    E-Print Network [OSTI]

    Neil Russell

    2015-01-11

    A method is presented for deducing classical point-particle Lagrange functions corresponding to a class of quartic dispersion relations. Applying this to particles violating Lorentz symmetry in the minimal Standard-Model Extension leads to a variety of novel lagrangians in flat spacetime. Morphisms in these classical systems are studied that echo invariance under field redefinitions in the quantized theory. The Lagrange functions found offer new possibilities for understanding Lorentz-breaking effects by exploring parallels with Finsler-like geometries.

  15. System Break-Out Session | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergyPlan | Department ofSUPPLEMENTSwitzerland 2012 ProgramSynergyBreak-Out

  16. Upper tropospheric drying and the ``transition to break'' in the Indian summer monsoon during 1999

    E-Print Network [OSTI]

    Roca, Rémy

    level convergence. A rapid shift occurs in divergence field during transition with convergence replacing to transition in to a break phase from an active monsoon phase. 1.1. Active and Break Spells [3] Infra RedUpper tropospheric drying and the ``transition to break'' in the Indian summer monsoon during 1999

  17. The Szilard engine revisited: Entropy, macroscopic randomness, and symmetry breaking phase transitions

    E-Print Network [OSTI]

    Parrondo, Juan M.R.

    The Szilard engine revisited: Entropy, macroscopic randomness, and symmetry breaking phase 2001 The role of symmetry breaking phase transitions in the Szilard engine is analyzed. It is shown that symmetry breaking is the only necessary ingredient for the engine to work. To support this idea, we show

  18. Under consideration for publication in J. Fluid Mech. 1 Dam breaking seiches

    E-Print Network [OSTI]

    Balmforth, Neil

    Under consideration for publication in J. Fluid Mech. 1 Dam breaking seiches N. J. Balmforth1, J the break of a moraine dam by catastrophic erosional incision initiated by overtopping with a displacement confirm that dams can be broken by a catastrophic incision. However, the displacement wave does not break

  19. FLASH predictions of the MB-2 steam line break tests

    SciTech Connect (OSTI)

    Lincoln, F.W.; Coffield, R.D.; Johnson, E.G.

    1992-12-31

    If a main steam line from a pressurized water reactor (PWR) steam generator were to rupture, the effect would be a depressurization of the secondary side and a consequential overcooling transient on the primary side. Analyses must accurately predict the effects of the rapid cooldown of the reactor vessel coolant on positive nuclear-kinetic reactivity feedback to the core plus thermal shock to the reactor vessel and other primary system components. Many early studies of the steam line break (SLB) transient made extremely conservative assumptions to maximize the primary to secondary heat transfer which in turn maximized the reactor vessel cooldown rate. Among the more significant of these assumptions was that flow from the break was pure steam and that the tube bundle remained covered until the secondary mass inventory was significantly reduced. The Model F commercial PWR steam generator testing performed in the Model Boiler No. 2 (MB-2) facility located at the Westinghouse Engineering Test Facility in Tampa, Florida provided data to better qualify the actual variation in these key parameters. A conclusion of this analysis is that the MB-2 steam line break data base is accurate and of sufficient detail to provide a valuable basis for making comparisons relative to code predictions. Results obtained using the FLASH transient safety analysis code were found to be in excellent agreement with the data.

  20. Peccei-Quinn Symmetry from Dynamical Supersymmetry Breaking

    E-Print Network [OSTI]

    Harigaya, Keisuke; Schmitz, Kai; Yanagida, Tsutomu T

    2015-01-01

    The proximity of the Peccei-Quinn scale to the scale of supersymmetry breaking in models of pure gravity mediation hints at a common dynamical origin of these two scales. To demonstrate how to make such a connection manifest, we embed the Peccei-Quinn mechanism into the vector-like model of dynamical supersymmetry breaking a la IYIT. Here, we rely on the anomaly-free discrete Z4R symmetry required in models of pure gravity mediation to solve the mu problem to protect the Peccei-Quinn symmetry from the dangerous effect of higher-dimensional operators. This results in a rich phenomenology featuring a QCD axion with a decay constant of O(10^10) GeV and mixed WIMP/axion dark matter. In addition, exactly five pairs of extra 5 and 5* matter multiplets, directly coupled to the supersymmetry breaking sector and with masses close to the gravitino mass, m3/2 ~ 100 TeV, are needed to cancel the Z4R anomalies.

  1. Peccei-Quinn Symmetry from Dynamical Supersymmetry Breaking

    E-Print Network [OSTI]

    Keisuke Harigaya; Masahiro Ibe; Kai Schmitz; Tsutomu T. Yanagida

    2015-05-27

    The proximity of the Peccei-Quinn scale to the scale of supersymmetry breaking in models of pure gravity mediation hints at a common dynamical origin of these two scales. To demonstrate how to make such a connection manifest, we embed the Peccei-Quinn mechanism into the vector-like model of dynamical supersymmetry breaking a la IYIT. Here, we rely on the anomaly-free discrete Z4R symmetry required in models of pure gravity mediation to solve the mu problem to protect the Peccei-Quinn symmetry from the dangerous effect of higher-dimensional operators. This results in a rich phenomenology featuring a QCD axion with a decay constant of O(10^10) GeV and mixed WIMP/axion dark matter. In addition, exactly five pairs of extra 5 and 5* matter multiplets, directly coupled to the supersymmetry breaking sector and with masses close to the gravitino mass, m3/2 ~ 100 TeV, are needed to cancel the Z4R anomalies.

  2. Supersymmetric Custodial Higgs Triplets and the Breaking of Universality

    E-Print Network [OSTI]

    Mateo Garcia-Pepin; Stefania Gori; Mariano Quiros; Roberto Vega; Roberto Vega-Morales; Tien-Tien Yu

    2014-12-21

    Higgs triplet models are known to have difficulties obtaining agreement with electroweak precision data and in particular constraints on the $\\rho$ parameter. Either a global $SU(2)_L \\otimes SU(2)_R$ symmetry has to be imposed on the scalar potential at the electroweak scale, as done in the well-known Georgi-Machacek (GM) model, or the triplet vacuum expectation values must be very small. We construct a supersymmetric model that can satisfy constraints on the $\\rho$ parameter, even if these two conditions are not fulfilled. We supersymmetrize the GM model by imposing the $SU(2)_L \\otimes SU(2)_R$ symmetry at a scale $\\mathcal M$, which we argue should be at or above the messenger scale, where supersymmetry breaking is transmitted to the observable sector. We show that scales $\\mathcal M$ well above 100 TeV and sizable contributions from the triplets to electroweak symmetry breaking can be comfortably accommodated. We discuss the main phenomenological properties of the model and demonstrate that the departure from custodial symmetry at the electroweak scale, due to radiative breaking, can show up at the LHC as a deviation in the `universal' relation for the Higgs couplings to $WW$ and $ZZ$. As a by-product of supersymmetry, we also show that one can easily obtain both large tree-level \\emph{and} one loop corrections to the Higgs mass. This allows for stops that can be significantly lighter and with smaller mixing than those needed in the MSSM.

  3. Method of tissue repair using a composite material

    DOE Patents [OSTI]

    Hutchens, Stacy A; Woodward, Jonathan; Evans, Barbara R; O'Neill, Hugh M

    2014-03-18

    A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

  4. Development and validation of bonded composite doubler repairs for commercial aircraft.

    SciTech Connect (OSTI)

    Roach, Dennis Patrick; Rackow, Kirk A.

    2007-07-01

    A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack, impact, and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safely extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC), Boeing, and Federal Express completed a pilot program to validate and introduce composite doubler repair technology to the U.S. commercial aircraft industry. This project focused on repair of DC-10 fuselage structure and its primary goal was to demonstrate routine use of this repair technology using niche applications that streamline the design-to-installation process. As composite doubler repairs gradually appear in the commercial aircraft arena, successful flight operation data is being accumulated. These commercial aircraft repairs are not only demonstrating the engineering and economic advantages of composite doubler technology but they are also establishing the ability of commercial maintenance depots to safely adopt this repair technique. This report presents the array of engineering activities that were completed in order to make this technology available for widespread commercial aircraft use. Focused laboratory testing was conducted to compliment the field data and to address specific issues regarding damage tolerance and flaw growth in composite doubler repairs. Fatigue and strength tests were performed on a simulated wing repair using a substandard design and a flawed installation. In addition, the new Sol-Gel surface preparation technique was evaluated. Fatigue coupon tests produced Sol-Gel results that could be compared with a large performance database from conventional, riveted repairs. It was demonstrated that not only can composite doublers perform well in severe off-design conditions (low doubler stiffness and presence of defects in doubler installation) but that the Sol-Gel surface preparation technique is easier and quicker to carry out while still producing optimum bonding properties. Nondestructive inspection (NDI) methods were developed so that the potential for disbond and delamination growth could be monitored and crack growth mitigation could be quantified. The NDI methods were validated using full-scale test articles and the FedEx aircraft installations. It was demonstrated that specialized NDI techniques can detect flaws in composite doubler installations before they reach critical size. Probability of Detection studies were integrated into the FedEx training in order to quantify the ability of aircraft maintenance depots to properly monitor these repairs. In addition, Boeing Structural Repair and Nondestructive Testing Manuals were modified to include composite doubler repair and inspection procedures. This report presents the results from the FedEx Pilot Program that involved installation and surveillance of numerous repairs on operating aircraft. Results from critical NDI evaluations are reported in light of damage tolerance assessments for bonded composite doublers. This work has produced significant interest from airlines and aircraft manufacturers. The successful Pilot Program produced flight performance history to establish the durability of bonded composite patches as a permanent repair on commercial aircraft structures. This report discusses both the laboratory data and Pilot Program results from repair installations on operating aircraft to introduce composite doubler repairs into mainstream commercial aircraft use.

  5. DNA repair of a single UV photoproduct in a designed nucleosome

    SciTech Connect (OSTI)

    Kosmoskil, Joseph V.; Ackerman, Eric J. ); Smerdon, Michael J.

    2001-08-28

    Eukaryotic DNA repair enzymes must interact with the architectural hierarchy of chromatin. The challenge of finding damaged DNA complexed with histone proteins in nucleosomes is complicated by the need to maintain local chromatin structures involved in regulating other DNA processing events. The heterogeneity of lesions induced by DNA-damaging agents has led us to design homogeneously damaged substrates to directly compare repair of naked DNA with that of nucleosomes. Here we report that nucleotide excision repair in Xenopus nuclear extracts can effectively repair a single UV radiation photoproduct located 5 bases from the dyad center of a positioned nucleosome, although the nucleosome is repaired at about half the rate at which the naked DNA fragment is. Extract repair within the nucleosome is > 50-fold more rapid than either enzymatic photoreversal or endonuclease cleavage of the lesion in vitro. Furthermore, nucleosome formation occurs (after repair) only on damaged naked DNA ( 165-bp fragments) during a 1-h incubation in these extracts, even in the presence of a large excess of undamaged DNA. This is an example of selective nucleosome assembly by Xenopus nuclear extracts on a short linear DNA fragment containing a DNA lesion.

  6. Nanodiamond dust and the far-ultraviolet quasar break

    E-Print Network [OSTI]

    L. Binette; G. Magris C.; Y. Krongold; C. Morisset; S. Haro-Corzo; J. A. de Diego; H. Mutschke; A. C. Andersen

    2005-05-29

    We explore the possibility that the steepening observed shortward of 1000A in the energy distribution of quasars may result from absorption by dust, being either intrinsic to the quasar environment or intergalactic. We find that a dust extinction curve consisting of nanodiamonds, composed of terrestrial cubic diamonds or with surface impurities as found in carbonaceous chondrite meteorites, such as Allende, is successful in reproducing the sharp break observed. The intergalactic dust model is partially successful in explaining the shape of the composite energy distribution, but must be discarded in the end, as the amount of crystalline dust required is unreasonable and would imply an improbable fine tuning among the dust formation processes. The alternative intrinsic dust model requires a mixture of both cubic diamonds and Allende nanodiamonds and provide a better fit of the UV break. The gas column densities implied are of the order 10^{20} cm^{-2} assuming solar metallicity for carbon and full depletion of carbon into dust. The absorption only occurs in the ultraviolet and is totally negligible in the visible. The minimum dust mass required is of the order ~ 0.003 r_{pc}^{2}M_o, where r_{pc} is the distance in parsec between the dust screen and the continuum source. The intrinsic dust model reproduces the flux {\\it rise} observed around 660A in key quasar spectra quite well. We present indirect evidence of a shallow continuum break near 670A (18.5 eV), which would be intrinsic to the quasar continuum.

  7. Revolving D-branes and Spontaneous Gauge Symmetry Breaking

    E-Print Network [OSTI]

    Satoshi Iso; Noriaki Kitazawa

    2015-10-07

    We propose a new mechanism of spontaneous gauge symmetry breaking in the world-volume theory of revolving D-branes around a fixed point of orbifolds. In this paper, we consider a simple model of the T6/Z3 orbifold on which we put D3-branes, D7-branes and their anti-branes. The configuration breaks supersymmetry, but the R-R tadpole cancellation conditions are satisfied. A set of three D3-branes at an orbifold fixed point can separate from the point, but when they move perpendicular to the anti-D7-branes put on the fixed point, they are forced to be pulled back due to an attractive interaction between the D3 and anti-D7 branes. In order to stabilize the separation of the D3-branes at nonzero distance, we consider revolution of the D3-branes around the fixed point. Then the gauge symmetry on D3-branes is spontaneously broken, and the rank of the gauge group is reduced. The distance can be set at our will by appropriately choosing the angular momentum of the revolving D3-branes, which should be determined by the initial condition of the cosmological evolution of D-brane configurations. The distance corresponds to the vacuum expectation values of brane moduli fields in the world-volume theory and, if it is written as M/Ms^2 in terms of the string scale Ms, the scale of gauge symmetry breaking is given by M. Angular momentum conservation of revolving D3-branes assures the stability of the scale M against Ms.

  8. PT symmetry and spontaneous symmetry breaking in a microwave billiard

    E-Print Network [OSTI]

    S. Bittner; B. Dietz; U. Guenther; H. L. Harney; M. Miski-Oglu; A. Richter; F. Schaefer

    2011-12-02

    We demonstrate the presence of parity-time (PT) symmetry for the non-Hermitian two-state Hamiltonian of a dissipative microwave billiard in the vicinity of an exceptional point (EP). The shape of the billiard depends on two parameters. The Hamiltonian is determined from the measured resonance spectrum on a fine grid in the parameter plane. After applying a purely imaginary diagonal shift to the Hamiltonian, its eigenvalues are either real or complex conjugate on a curve, which passes through the EP. An appropriate basis choice reveals its PT symmetry. Spontaneous symmetry breaking occurs at the EP.

  9. Comparison of symmetry breaking in the canonical and microcanonical ensembles

    SciTech Connect (OSTI)

    Arthur Weldon, H. (Department of Physics, West Virginia University, Morgantown, West Virginia 26506 (US))

    1989-07-01

    High temperature field theories have always been formulated in the canonical ensemble (i.e., fixed {ital T}). Here the same theories are investigated in the microcanonical ensemble (i.e., fixed total energy {ital E}). To incorporate spontaneous symmetry breaking a microcanonical analogue of the effective potential is developed. There is a critical value of the energy {ital E}{sub {ital c}} which separates the broken from the unbroken phase. Explicit one loop calculations in the two ensembles allow for detailed comparisons and lead to agreement in the limit {ital VT}{sup 3}{r arrow}{infinity}. {copyright} 1989 Academic Press, Inc.

  10. Leak before break application in French PWR plants under operation

    SciTech Connect (OSTI)

    Faidy, C. [EDF SEPTEN, Villeurbanne (France)

    1997-04-01

    Practical applications of the leak-before break concept are presently limited in French Pressurized Water Reactors (PWR) compared to Fast Breeder Reactors. Neithertheless, different fracture mechanic demonstrations have been done on different primary, auxiliary and secondary PWR piping systems based on similar requirements that the American NUREG 1061 specifications. The consequences of the success in different demonstrations are still in discussion to be included in the global safety assessment of the plants, such as the consequences on in-service inspections, leak detection systems, support optimization,.... A large research and development program, realized in different co-operative agreements, completes the general approach.

  11. Breaking a Pocket of Resistance in the Fight Against Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAudits &Bradbury Science Museum - Science onBranding &Breaking a

  12. Breaking the ties that bind: New hope for biomass fuels

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAudits &Bradbury Science Museum - Science onBranding &Breaking aNew

  13. Breaking the Fuel Cell Cost Barrier | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum Based Fuels Researchof Energy|Make6,Energy1Breaking the Fuel Cell Cost

  14. Breaking the Biological Barriers to Cellulosic Ethanol, June 2006 |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative FuelsofProgram:Y-12Power, IncBio CentersBreaking Up (Hydrogen) No Longer As Hard To

  15. Modeling and centralization of strategic inventory for repairable and long lead-time spare parts

    E-Print Network [OSTI]

    Duncan, Tyeliah Elaine

    2011-01-01

    This thesis develops an optimal inventory model for repairable and long leadtime spare parts for an Engine overhaul business. In addition, it presents a business case for centralization of inventory. Pratt & Whitney purchased ...

  16. Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement

    E-Print Network [OSTI]

    2015-01-01

    and J. D. Puskas. Mitral-valve repair versus replacement forbioprosthetic heart valves. Ann. Thorac. Surg. 71:S417–mechanics of arti?cial heart valves. Clin. Exp. Pharmacol.

  17. Review of Maintenance and Repair Times for Components in Technological Facilities

    SciTech Connect (OSTI)

    L. C. Cadwallader

    2012-11-01

    This report is a compilation of some unique component repair time data and it also presents citations of more extensive reports where lists of repair times can be found. This collection of information should support analysts who seek to quantify maintainability and availability of high technology and nuclear energy production systems. While there are newer sources of repair time information, most, if not all, of the newer sources are proprietary and cannot be shared. This report offers data that, while older, is openly accessible and can serve as reasonable estimates of repair times, at least for initial studies. Some times were found for maintenance times in radiation environments, and some guidance for multiplicative factors to use to account for work in contamination areas.

  18. Tiny Terminators: New Micro-Robots Assemble, Repair Themselves and Are Surprisingly Strong

    Broader source: Energy.gov [DOE]

    Tiny robots that can assemble and repair themselves? Watch a video of Argonne National Laboratory's micro-robots that easily perform tasks that can challenge other robots, including moving objects that are larger than themselves.

  19. Bruce Podwal Seminar Series Implementing Emergency Foundation Repairs on I-495 in Delaware

    E-Print Network [OSTI]

    Sun, Yi

    to be misaligned. Delaware Department of Transportation (DelDOT) responded immediately by shutting down the bridgeBruce Podwal Seminar Series Implementing Emergency Foundation Repairs on I-495 in Delaware Tuesday

  20. Development/Plasticity/Repair Persistence of Experience-Induced Homeostatic Synaptic

    E-Print Network [OSTI]

    Lee, Hey-Kyoung

    Development/Plasticity/Repair Persistence of Experience-Induced Homeostatic Synaptic Plasticity. Theoretical analyses indicate that there are two synaptic plasticity mechanisms required: input. Experience-dependent homeostatic synaptic plasticity mechanisms have subsequently been demonstrated

  1. Use of CFRP Overlays to Repair Fatigue Damage in Steel Bridge Girders and Components

    E-Print Network [OSTI]

    Gangel, Regan Elisabeth

    2012-05-31

    Fatigue damage in steel girder bridges built prior to the mid-1980s is common due to distortion-induced fatigue. Different repair techniques have been developed and implemented to retrofit bridges of this era with existing ...

  2. REPAIR OF BRIDGE STEEL GIRDERS DAMAGED BY DISTORTION-INDUCED FATIGUE

    E-Print Network [OSTI]

    Alemdar, Fatih

    2011-12-31

    This study investigates the repair of steel bridge girders damaged by distortion-induced fatigue. The study is presented in three parts. The first part describes finite element modeling techniques used to evaluate the ...

  3. Plug repairs of marine glass fiber / vinyl ester laminates subjected to uniaxial tension

    E-Print Network [OSTI]

    Michelis, Alexandros

    2009-01-01

    Glass fiber/vinyl ester composite laminates are currently being used and proposed for the hulls, bulkheads, and superstructures of large ships. This thesis examines the effectiveness of the repair of such laminates using ...

  4. A Self-Repairing Peer-to-Peer System Resilient to Dynamic Adversarial Churn

    E-Print Network [OSTI]

    A Self-Repairing Peer-to-Peer System Resilient to Dynamic Adversarial Churn Fabian Kuhn, Stefan at any time. Such peers join and leave the P2P system at high rates ("churn"), a problem

  5. A Self-Repairing Peer-to-Peer System Resilient to Dynamic Adversarial Churn

    E-Print Network [OSTI]

    A Self-Repairing Peer-to-Peer System Resilient to Dynamic Adversarial Churn Fabian Kuhn, Stefan rates ("churn"), a problem that is not existent in orthodox distributed systems. In other words, a P2P

  6. Inorganic-Organic Shape Memory Polymers and Foams for Bone Defect Repairs 

    E-Print Network [OSTI]

    Zhang, Dawei

    2013-04-16

    The ultimate goal of this research was to develop a “self-fitting” shape memory polymer (SMP) scaffold for the repair of craniomaxillofacial (CMF) bone defects. CMF defects may be caused by trauma, tumor removal or congenital abnormalities...

  7. Community-Minded Interns at Savannah River Site Help Area Residents in Need with Home Repairs

    Broader source: Energy.gov [DOE]

    AIKEN, S.C. – More than two dozen college interns who worked at the Savannah River Site (SRS) this summer joined other volunteers and headed into area neighborhoods to help people in need with home repairs.

  8. Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Su, Fengtao; Mukherjee, Shibani; Yang, Yanyong; Mori, Eiichiro; Bhattacharya, Souparno; Kobayashi, Junya; Yannone, Steven  M.; Chen, David  J.; Asaithamby, Aroumougame

    2014-11-20

    WRN, the protein defective in Werner syndrome (WS), is a multifunctional nuclease involved in DNA damage repair, replication, and genome stability maintenance. It was assumed that the nuclease activities of WRN were critical for these functions. Here, we report a nonenzymatic role for WRN in preserving nascent DNA strands following replication stress. We found that lack of WRN led to shortening of nascent DNA strands after replication stress. Furthermore, we discovered that the exonuclease activity of MRE11 was responsible for the shortening of newly replicated DNA in the absence of WRN. Mechanistically, the N-terminal FHA domain of NBS1 recruits WRNmore »to replication-associated DNA double-stranded breaks to stabilize Rad51 and to limit the nuclease activity of its C-terminal binding partner MRE11. Thus, this previously unrecognized nonenzymatic function of WRN in the stabilization of nascent DNA strands sheds light on the molecular reason for the origin of genome instability in WS individuals.« less

  9. the Adaptive Response, Genetic Haplo-Insufficiency and Genomic Instability

    SciTech Connect (OSTI)

    Geard, Charles R.

    2014-12-12

    The linear no-threshold (LNT) hypothesis is the driving force in the establishment of radiation protection standards. However, the scientific basis for linearity has been brought into question, particularly due to the concerns about induced radiation resistance as it pertains to oxidative stress. Specifically, we investigated the observation that tumor hypoxia is associated with malignant progression, increased metastases, chemo- and radioresistance and poor prognosis. Experiments were conducted with non-malignant 3T3/NIH cells and normal human lung fibroblasts (NHLF) that were subjected to ?-irradiation under the levels of oxygen resembling those in growing tumors, and related our data to the concentrations of dissolved oxygen (DO), which is a better indicator of the amounts of residual oxygen inside the cells cultured in the hypoxic or anoxic atmosphere. We found that at DO levels about 0.5 mg/L cells subjected to both short-term (17 hours) and prolonged (48-72 hours) hypoxia continued to proliferate, and that apoptotic events were decreased at the early hours of hypoxic treatment. We showed that the short-term hypoxia up-regulated p53-binding protein 1 (53BP1) and resulted in facilitated 53BP1 nuclear foci formation and disappearance, thus indicating the higher efficiency of DNA double strand breaks repair processes. The latter was confirmed by the lower micronuclei incidence in irradiated hypoxic cells.

  10. RESTORING A DAMAGED 16-YEAR -OLD INSULATING POLYMER CONCRETE DIKE OVERLAY: REPAIR MATERIALS AND TECHNOLOGIES.

    SciTech Connect (OSTI)

    SUGAMA,T.

    2007-01-01

    The objective of this program was to design and formulate organic polymer-based material systems suitable for repairing and restoring the overlay panels of insulating lightweight polymer concrete (ILPC) from the concrete floor and slope wall of a dike at KeySpan liquefied natural gas (LNG) facility in Greenpoint, Brooklyn, NY, just over sixteen years ago. It also included undertaking a small-scale field demonstration to ensure that the commercial repairing technologies were applicable to the designed and formulated materials.

  11. DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage

    E-Print Network [OSTI]

    Marchetti, Francesco

    2008-01-01

    male germ cells handle DNA damage? Toxicol. Appl. Pharmacol.strand breaks and DNA base damage at different cellularrelationship to genetic damage, Mutat. Res. 216 (1989) 221-

  12. DNA Repair Decline During Mouse Spermiogenesis Results in the Accumulation of Heritable DNA Damage

    E-Print Network [OSTI]

    Marchetti, Francesco

    2008-01-01

    male germ cells handle DNA damage? Toxicol. Appl. Pharmacol.strand breaks and DNA base damage at different cellularrelationship to genetic damage, Mutat. Res. 216 (1989) 221-

  13. Pulsar Emission above the Spectral Break - A Stacked Approach

    E-Print Network [OSTI]

    McCann, Andrew

    2015-01-01

    NASA's Fermi space telescope has provided us with a bountiful new population of gamma-ray sources following its discovery of 150 new gamma-ray pulsars. One common feature exhibited by all of these pulsars is the form of their spectral energy distribution, which can be described by a power law followed by a spectral break occurring between $\\sim$1 and $\\sim$8 GeV. The common wisdom is that the break is followed by an exponential cut-off driven by radiation/reaction-limited curvature emission. The discovery of pulsed gamma rays from the Crab pulsar, the only pulsar so far detected at very high energies (E$>$100GeV), contradicts this "cutoff" picture. Here we present a new stacked analysis with an average of 4.2 years of data on 115 pulsars published in the 2nd LAT catalog of pulsars. This analysis is sensitive to low-level $\\sim$100 GeV emission which cannot be resolved in individual pulsars but can be detected from an ensemble.

  14. Intermediate-break LOCA analyses for the AP600 design

    SciTech Connect (OSTI)

    Boyack, B.E.; Lime, J.F.

    1995-07-01

    A postulated double-ended guillotine break of a direct-vessel-injection line in an AP600 plant has been analyzed. This event is characterized as an intermediate break loss-of-coolant accident (IBLOCA). Most of the insights regarding the response of the AP600 safety systems to the postulated accident are derived from calculations performed with the TRAC-PFl/MOD2 code. However, complementary insights derived from a scaled experiment conducted in the ROSA facility, as well as insights based upon calculations by other codes, are also presented. The key processes occurring in an AP600 during a IBLOCA are primary coolant system depressurization, inventory depletion, inventory replacement via emergency core coolant injection, continuous core cooling, and long-term decay heat rejection to the atmosphere. Based upon the calculated and experimental results, the AP600 will not experience a core heat up and will reach a safe shutdown state using only safety-class equipment. Only the early part of the long-term cooling period initiated by In-containment Refueling Water Storage Tank injection was evaluated Thus, the observation that the core is continuously cooled should be verified for the latter phase of the long-term cooling period, the interval when sump injection and containment cooling processes are important.

  15. CP breaking in $S(3)$ flavoured Higgs model

    E-Print Network [OSTI]

    E. Barradas-Guevara; O. Félix-Beltrán; E. Rodríguez-Jáuregui

    2015-07-18

    We analyze the Higgs sector of the minimal $S(3)$-invariant extension of the Standard Model including CP violation arising from the spontaneous breaking of the electroweak symmetry. This extended Higgs sector includes three $SU(2)$ doublets Higgs fields with complex vev's provide an interesting scenario to analyze the Higgs masses spectrum, trilinear self-couplings and CP violation. We present how the spontaneous electroweak symmetry breaking coming from three $S(3)$ Higgs fields gives an interesting scenario with nine physical Higgs and three Goldstone bosons when spontaneous CP violation arises from the Higgs field $S(3)$ singlet $H_S$. Furthermore, numerical analysis of the Higgs masses and trilinear self-couplings is presented, particularly we find a physical solution for the scenario in which spontaneous CPB is provided by the single field $H_S$. The scalar Higgs $H_4^0$ is identified whose mass is 125 GeV and $\\lambda_{H_{4}^0 H_{4}^0 H_{4}^0} \\sim \\lambda_{h^0 h^0 h^0}^{SM}$ in good agreement with the latest experimental results.

  16. Spontaneous Symmetry Breaking in Presence of Electric and Magnetic Charges

    E-Print Network [OSTI]

    Pushpa; P. S. Bisht; O. P. S. Negi

    2010-11-17

    Starting with the definition of quaternion gauge theory, we have undertaken the study of SU(2)_{e}\\times SU(2)_{m}\\times U(1)_{e}\\times U(1)_{m} in terms of the simultaneous existence of electric and magnetic charges along with their Yang - Mills counterparts. As such, we have developed the gauge theory in terms of four coupling constants associated with four - gauge symmetry SU(2)_{e}\\times SU(2)_{m}\\times U(1)_{e}\\times U(1)_{m}. Accordingly, we have made an attempt to obtain the abelian and non - Abelian gauge structures for the particles carrying simultaneously the electric and magnetic charges (namely dyons). Starting from the Lagrangian density of two SU(2)\\times U(1) gauge theories responsible for the existence of electric and magnetic charges, we have discussed the consistent theory of spontaneous symmetry breaking and Higgs mechanism in order to generate the masses. From the symmetry breaking, we have generated the two electromagnetic fields, the two massive vector W^{\\pm} and Z^{0} bosons fields and the Higgs scalar fields.

  17. Brane World as a Result of Spontaneous Symmetry Breaking

    E-Print Network [OSTI]

    Boris E. Meierovich

    2009-10-09

    The theories of brane world and multidimensional gravity are widely discussed in the literature in connection with problems of evolution of early Universe, including dark matter and energy. A natural physical concept is that a distinguished surface in the space-time manifold is a topological defect appeared as a result of a phase transition with spontaneous symmetry breaking. The macroscopic theory of phase transitions allows considering the brane world concept self-consistently, even without the knowledge of the nature of physical vacuum. Gravitational properties of topological defects (cosmic strings, monopoles,...) in extra dimensions are studied in General Relativity considering the order parameter as a vector and a multiplet in a plane target space of scalar fields. The common results and differences of these two approaches are analyzed and demonstrated in detail. Among the variety of regular solutions, there are those having brane features, including solutions with multiple branes, as well as the ones of potential interest from the standpoint of the dark matter and hierarchy problems. Regular configurations have a growing gravitational potential and are able to trap the matter on the brane. If the energy of spontaneous symmetry breaking is high, the attracting potential can have several points of minimum. Identical in the uniform bulk spin-less particles, being trapped within the separate points of minimum, acquire different masses and appear to an observer on brane as different particles with integer spins.

  18. Flavour symmetry breaking in the kaon parton distribution amplitude

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    none,

    2014-11-01

    We compute the kaon's valence-quark (twist-two parton) distribution amplitude (PDA) by projecting its Poincaré-covariant Bethe–Salpeter wave-function onto the light-front. At a scale ? = 2 GeV, the PDA is a broad, concave and asymmetric function, whose peak is shifted 12–16% away from its position in QCD's conformal limit. These features are a clear expression of SU(3)-flavour-symmetry breaking. They show that the heavier quark in the kaon carries more of the bound-state's momentum than the lighter quark and also that emergent phenomena in QCD modulate the magnitude of flavour-symmetry breaking: it is markedly smaller than one might expect based on themore »difference between light-quark current masses. Our results add to a body of evidence which indicates that at any energy scale accessible with existing or foreseeable facilities, a reliable guide to the interpretation of experiment requires the use of such nonperturbatively broadened PDAs in leading-order, leading-twist formulae for hard exclusive processes instead of the asymptotic PDA associated with QCD's conformal limit. We illustrate this via the ratio of kaon and pion electromagnetic form factors: using our nonperturbative PDAs in the appropriate formulae, FK/F?=1.23 at spacelike-Q2=17 GeV2, which compares satisfactorily with the value of 0.92(5) inferred in e+e- annihilation at s=17 GeV2.« less

  19. Revolving D-branes and Spontaneous Gauge Symmetry Breaking

    E-Print Network [OSTI]

    Iso, Satoshi

    2015-01-01

    We propose a new mechanism of spontaneous gauge symmetry breaking in the world-volume theory of revolving D-branes around a fixed point of orbifolds. In this paper, we consider a simple model of the T6/Z3 orbifold on which we put D3-branes, D7-branes and their anti-branes. The configuration breaks supersymmetry, but the R-R tadpole cancellation conditions are satisfied. A set of three D3-branes at an orbifold fixed point can separate from the point, but when they move perpendicular to the anti-D7-branes put on the fixed point, they are forced to be pulled back due to an attractive interaction between the D3 and anti-D7 branes. In order to stabilize the separation of the D3-branes at nonzero distance, we consider revolution of the D3-branes around the fixed point. Then the gauge symmetry on D3-branes is spontaneously broken, and the rank of the gauge group is reduced. The distance can be set at our will by appropriately choosing the angular momentum of the revolving D3-branes, which should be determined by the...

  20. Reconstitution of the cellular response to DNA damage in vitro using damage-activated extracts from mammalian cells

    SciTech Connect (OSTI)

    Roper, Katherine; Coverley, Dawn

    2012-03-10

    In proliferating mammalian cells, DNA damage is detected by sensors that elicit a cellular response which arrests the cell cycle and repairs the damage. As part of the DNA damage response, DNA replication is inhibited and, within seconds, histone H2AX is phosphorylated. Here we describe a cell-free system that reconstitutes the cellular response to DNA double strand breaks using damage-activated cell extracts and naieve nuclei. Using this system the effect of damage signalling on nuclei that do not contain DNA lesions can be studied, thereby uncoupling signalling and repair. Soluble extracts from G1/S phase cells that were treated with etoposide before isolation, or pre-incubated with nuclei from etoposide-treated cells during an in vitro activation reaction, restrain both initiation and elongation of DNA replication in naieve nuclei. At the same time, H2AX is phosphorylated in naieve nuclei in a manner that is dependent upon the phosphatidylinositol 3-kinase-like protein kinases. Notably, phosphorylated H2AX is not focal in naieve nuclei, but is evident throughout the nucleus suggesting that in the absence of DNA lesions the signal is not amplified such that discrete foci can be detected. This system offers a novel screening approach for inhibitors of DNA damage response kinases, which we demonstrate using the inhibitors wortmannin and LY294002. -- Highlights: Black-Right-Pointing-Pointer A cell free system that reconstitutes the response to DNA damage in the absence of DNA lesions. Black-Right-Pointing-Pointer Damage-activated extracts impose the cellular response to DNA damage on naieve nuclei. Black-Right-Pointing-Pointer PIKK-dependent response impacts positively and negatively on two separate fluorescent outputs. Black-Right-Pointing-Pointer Can be used to screen for inhibitors that impact on the response to damage but not on DNA repair. Black-Right-Pointing-Pointer LY294002 and wortmannin demonstrate the system's potential as a pathway focused screening approach.

  1. Influence of steam generator plugging and break size on large-break loss-of-collant accidents

    SciTech Connect (OSTI)

    Stritar, A.; Mavko, B. [Jozef Stefan Institute, Ljubljana (El Salvador)

    1991-07-01

    The large-break loss-of-coolant accident (LBLOCA) is the design-basis accident in the Krsko pressurized-water reactor, the only power reactor in Slovenia. Because numbers of steam generator tubes are plugged as the steam generator ages, and this directly influences the primary system behavior during an LBLOCA, this accident was re-examined assuming various proportions of blocked tube from 0 to 22%. The size of the break was changes from 25 to 45% of the initial cold-leg cross section. The analysis was made with RELAP4/MOD6 as the main code in the conservative mode rather than as the best-estimate code. The methodology separately considers the blowdown phase, the refill phase, and the reflood phase. It was found that the peak clad temperature rises as plugging increases up to about 10% plugging and tends to be constant or even decrease as the plugging increases beyond this point. It was also found that results are strongly dependent on the methodology used. 17 refs., 9 figs., 3 tabs.

  2. Development of bonded composite doublers for the repair of oil recovery equipment.

    SciTech Connect (OSTI)

    Roach, David W.; Rackow, Kirk A.

    2005-06-01

    An unavoidable by-product of a metallic structure's use is the appearance of crack and corrosion flaws. Economic barriers to the replacement of these structures have created an aging infrastructure and placed even greater demands on efficient and safe repair methods. In the past decade, an advanced composite repair technology has made great strides in commercial aviation use. Extensive testing and analysis, through joint programs between the Sandia Labs FAA Airworthiness Assurance Center and the aviation industry, have proven that composite materials can be used to repair damaged aluminum structure. Successful pilot programs have produced flight performance history to establish the durability of bonded composite patches as a permanent repair on commercial aircraft structures. With this foundation in place, this effort is adapting bonded composite repair technology to civil structures. The use of bonded composite doublers has the potential to correct the difficulties associated with current repair techniques and the ability to be applied where there are no rehabilitation options. It promises to be cost-effective with minimal disruption to the users of the structure. This report concludes a study into the application of composite patches on thick steel structures typically used in mining operations. Extreme fatigue, temperature, erosive, and corrosive environments induce an array of equipment damage. The current weld repair techniques for these structures provide a fatigue life that is inferior to that of the original plate. Subsequent cracking must be revisited on a regular basis. The use of composite doublers, which do not have brittle fracture problems such as those inherent in welds, can help extend the structure's fatigue life and reduce the equipment downtime. Two of the main issues for adapting aircraft composite repairs to civil applications are developing an installation technique for carbon steel and accommodating large repairs on extremely thick structures. This study developed and proved an optimum field installation process using specific mechanical and chemical surface preparation techniques coupled with unique, in-situ heating methods. In addition, a comprehensive performance assessment of composite doubler repairs was completed to establish the viability of this technology for large, steel structures. The factors influencing the durability of composite patches in severe field environments were evaluated along with related laminate design issues.

  3. INTERNAL REPAIR OF GAS PIPLINES SURVEY OF OPERATOR EXPERIENCE AND INDUSTRY NEEDS REPORT

    SciTech Connect (OSTI)

    Ian D. Harris

    2003-09-01

    A repair method that can be applied from the inside of a gas transmission pipeline (i.e., a trenchless repair) is an attractive alternative to conventional repair methods since the need to excavate the pipeline is precluded. This is particularly true for pipelines in environmentally sensitive and highly populated areas. The objectives of the project are to evaluate, develop, demonstrate, and validate internal repair methods for pipelines; develop a functional specification for an internal pipeline repair system; and prepare a recommended practice for internal repair of pipelines. The purpose of this survey is to better understand the needs and performance requirements of the natural gas transmission industry regarding internal repair. A total of fifty-six surveys were sent to pipeline operators. A total of twenty completed surveys were returned, representing a 36% response rate, which is considered very good given the fact that tailored surveys are known in the marketing industry to seldom attract more than a 10% response rate. The twenty survey responses produced the following principal conclusions: (1) Use of internal weld repair is most attractive for river crossings, under other bodies of water (e.g., lakes and swamps) in difficult soil conditions, under highways, under congested intersections, and under railway crossings. All these areas tend to be very difficult and very costly if, and where, conventional excavated repairs may be currently used. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling (HDD) when a new bore must be created to solve a leak or other problem in a water/river crossing. (3) The typical travel distances required can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). In concept, these groups require pig-based systems; despooled umbilical systems could be considered for the first two groups. For the last group a self-propelled system with an onboard self-contained power and welding system is required. (4) Pipe size range requirements range from 50.8 mm (2 in.) through 1,219.2 mm (48 in.) in diameter. The most common size range for 80% to 90% of operators surveyed is 508 mm to 762 mm (20 in. to 30 in.) diameter, with 95% using 558.8 mm (22 in.) diameter pipe.

  4. ON THE EVOLUTION OF THE SPECTRAL BREAK IN THE AFTERGLOW OF GAMMA-RAY BURSTS

    SciTech Connect (OSTI)

    Dado, Shlomo; Dar, Arnon [Physics Department, Technion, Haifa 32000 (Israel)

    2012-02-20

    The temporal evolution of the spectral break in the time-resolved spectral energy density of the broadband afterglow of gamma-ray bursts (GRBs) 091127 and 080319B was shown recently to be inconsistent with that expected for the cooling break in the standard fireball model of GRBs. Here we show that it is, however, in good agreement with the predicted temporal evolution of the smooth injection break/bend in the cannonball model of GRBs.

  5. Lorentz Symmetry Breaking in $\\mathcal{N} =2$ Superspace

    E-Print Network [OSTI]

    Faizal, Mir

    2015-01-01

    In this paper, we will study the deformation of a three dimensional theory with $\\mathcal{N} =2$ supersymmetry. This theory will be deformed by the presence of a constant vector field. This deformation will break the Lorentz symmetry. So, we will analyse this theory using $\\mathcal{N} =2$ aether superspace. The $\\mathcal{N} =2$ aether superspace will be obtained from a deformation of the usual $\\mathcal{N} =2$ superspace. This will be done by deforming the generators of the three dimensional $\\mathcal{N} =2$ supersymmetry. After analysing this deformed superalgebra, we will derive an explicit expression for the superspace propagators in this deformed superspace. Finally, we will use these propagators for performing perturbative calculations.

  6. Chiral Symmetry Breaking in Bent-Core Liquid Crystals

    E-Print Network [OSTI]

    Lech Longa; Grzegorz Paj?k; Thomas Wydro

    2009-02-04

    By molecular modeling we demonstrate that the nematic long-range order discovered in bent-core liquid crystal systems should reveal further spatially homogeneous phases. Two of them are identified as a tetrahedratic nematic ($N_T$) phase with $D_{2d}$ symmetry and a chiral tetrahedratic nematic ($N_T^*$) phase with $D_2$ symmetry. These new phases were found for a lattice model with quadrupolar and octupolar anisotropic interactions using Mean Field theory and Monte Carlo simulations. The phase diagrams exhibit tetrahedratic ($T$), $N_T$ and $N_T^*$ phases, in addition to ordinary isotropic ($I$), uniaxial nematic ($N_U$) and biaxial nematic ($N_B$) phases. To our knowledge, this is the first molecular model with spontaneous chiral symmetry breaking in non-layered systems.

  7. Glassy slowdown and replica-symmetry-breaking instantons

    E-Print Network [OSTI]

    Allan Adams; Tarek Anous; Jaehoon Lee; Sho Yaida

    2015-03-30

    Glass-forming liquids exhibit a dramatic dynamical slowdown as the temperature is lowered. This can be attributed to relaxation proceeding via large structural rearrangements whose characteristic size increases as the system cools. These cooperative rearrangements are well modeled by instantons in a replica effective field theory, with the size of the dominant instanton encoding the liquid's cavity point-to-set correlation length. Varying the parameters of the effective theory corresponds to varying the statistics of the underlying free-energy landscape. We demonstrate that, for a wide range of parameters, replica-symmetry-breaking instantons dominate. The detailed structure of the dominant instanton provides a rich window into point-to-set correlations and glassy dynamics.

  8. Impact of an oblique breaking wave on a wall

    E-Print Network [OSTI]

    Shu, Jian-Jun

    2014-01-01

    The intention of this paper is to study impact force of an oblique-angled slamming wave acting on a rigid wall. In the present study the analytical approach is pursued based on a technique proposed by the author. A nonlinear theory in the context of potential flow is presented for determining accurately the free-surface profiles immediately after an oblique breaking wave impingement on the rigid vertical wall that suddenly starts from rest. The small-time expansion is taken as far as necessary to include the accelerating effect. The analytical solutions for the free-surface elevation are derived up to the third order. The results derived in this paper are of particular interest to the marine and offshore engineering industries, which will find the information useful for the design of ships, coastal and offshore.

  9. Single particles accelerate final stages of capillary break up

    E-Print Network [OSTI]

    Lindner, Anke; Wagner, Christian

    2015-01-01

    Droplet formation of suspensions is present in many industrial and technological processes such as coating and food engineering. Whilst the finite time singularity of the minimum neck diameter in capillary break-up of simple liquids can be described by well known self-similarity solutions, the pinching of non-Brownian suspension depends in a complex way on the particle dynamics in the thinning thread. Here we focus on the very dilute regime where the filament contains only isolated beads to identify the physical mechanisms leading to the pronounced acceleration of the filament thinning observed. This accelerated regime is characterized by an asymmetric shape of the filament with an enhanced curvature that depends on the size and the spatial distribution of the particles within the capillary thread.

  10. Single particles accelerate final stages of capillary break up

    E-Print Network [OSTI]

    Anke Lindner; Jorge Eduardo Fiscina; Christian Wagner

    2015-06-12

    Droplet formation of suspensions is present in many industrial and technological processes such as coating and food engineering. Whilst the finite time singularity of the minimum neck diameter in capillary break-up of simple liquids can be described by well known self-similarity solutions, the pinching of non-Brownian suspension depends in a complex way on the particle dynamics in the thinning thread. Here we focus on the very dilute regime where the filament contains only isolated beads to identify the physical mechanisms leading to the pronounced acceleration of the filament thinning observed. This accelerated regime is characterized by an asymmetric shape of the filament with an enhanced curvature that depends on the size and the spatial distribution of the particles within the capillary thread.

  11. A Symmetry Breaking Model for X Chromosome Inactivation

    E-Print Network [OSTI]

    M. Nicodemi; A. Prisco

    2008-01-17

    In mammals, dosage compensation of X linked genes in female cells is achieved by inactivation of one of their two X chromosomes which is randomly chosen. The earliest steps in X-inactivation (XCI), namely the mechanism whereby cells count their X chromosomes and choose between two equivalent X, remain mysterious. Starting from the recent discovery of X chromosome colocalization at the onset of X-inactivation, we propose a Statistical Mechanics model of XCI, which is investigated by computer simulations and checked against experimental data. Our model describes how a `blocking factor' complex is self-assembled and why only one is formed out of many diffusible molecules, resulting in a spontaneous symmetry breaking (SB) in the binding to two identical chromosomes. These results are used to derive a scenario of biological implications describing all current experimental evidences, e.g., the importance of colocalization.

  12. Multilepton signals of gauge mediated supersymmetry breaking at the LHC

    E-Print Network [OSTI]

    D'Hondt, Jorgen; Fuks, Benjamin; Mariotti, Alberto; Mawatari, Kentarou; Petersson, Christoffer; Redigolo, Diego

    2014-01-01

    We investigate multilepton LHC signals arising from electroweak processes involving sleptons. We consider the framework of general gauge mediated supersymmetry breaking, focusing on models where the low mass region of the superpartner spectrum consists of the three generations of charged sleptons and the nearly massless gravitino. We demonstrate how such models can provide an explanation for the anomalous four lepton events recently observed by the CMS collaboration, while satisfying other existing experimental constraints. The best fit to the CMS data is obtained for a selectron/smuon mass of around 145 GeV and a stau mass of around 90 GeV. These models also give rise to final states with more than four leptons, offering alternative channels in which they can be probed and we estimate the corresponding production rates at the LHC.

  13. Micropropulsion and microrheology in complex fluids via symmetry breaking

    E-Print Network [OSTI]

    Pak, On Shun; Brandt, Luca; Lauga, Eric; 10.1063/1.4758811

    2013-01-01

    Many biological fluids have polymeric microstructures and display non-Newtonian rheology. We take advantage of such nonlinear fluid behavior and combine it with geometrical symmetry-breaking to design a novel small-scale propeller able to move only in complex fluids. Its propulsion characteristics are explored numerically in an Oldroyd-B fluid for finite Deborah numbers while the small Deborah number limit is investigated analytically using a second-order fluid model. We then derive expressions relating the propulsion speed to the rheological properties of the complex fluid, allowing thus to infer the normal stress coefficients in the fluid from the locomotion of the propeller. Our simple mechanism can therefore be used either as a non-Newtonian micro-propeller or as a micro-rheometer.

  14. Gauge Invariance and Symmetry Breaking by Topology and Energy Gap

    E-Print Network [OSTI]

    Heissenberg, Carlo

    2015-01-01

    For the description of observables and states of a quantum system, it may be convenient to use a canonical Weyl algebra of which only a subalgebra $\\mathcal A$, with a non-trivial center $\\mathcal Z$, describes observables, the other Weyl operators playing the role of intertwiners between inequivalent representations of $\\mathcal A$. In particular, this gives rise to a gauge symmetry described by the action of $\\mathcal Z$. A distinguished case is when the center of the observables arises from the fundamental group of the manifold of the positions of the quantum system. Symmetries which do not commute with the topological invariants represented by elements of $\\mathcal Z$ are then spontaneously broken in each irreducible representation of the observable algebra, compatibly with an energy gap; such a breaking exhibits a mechanism radically different from Goldstone and Higgs mechanisms. This is clearly displayed by the quantum particle on a circle, the Bloch electron and the two body problem.

  15. Lorentz Symmetry Breaking in $\\mathcal{N} =2$ Superspace

    E-Print Network [OSTI]

    Mir Faizal; Prince A. Ganai

    2015-09-09

    In this paper, we will study the deformation of a three dimensional theory with $\\mathcal{N} =2$ supersymmetry. This theory will be deformed by the presence of a constant vector field. This deformation will break the Lorentz symmetry. So, we will analyse this theory using $\\mathcal{N} =2$ aether superspace. The $\\mathcal{N} =2$ aether superspace will be obtained from a deformation of the usual $\\mathcal{N} =2$ superspace. This will be done by deforming the generators of the three dimensional $\\mathcal{N} =2$ supersymmetry. After analysing this deformed superalgebra, we will derive an explicit expression for the superspace propagators in this deformed superspace. Finally, we will use these propagators for performing perturbative calculations.

  16. Relocation and repair of the National Geotechnical Centrifuge. Final report

    SciTech Connect (OSTI)

    Cheney, J.A.

    1994-10-01

    In January of 1984, the large geotechnical centrifuge located at NASA Ames Research Center, was in the first stages of operational checkout when the main thrust bearing of the large D.C. drive motor failed. After many months of investigation and proposals for repair of the facility, it became evident that it would be far more advantageous to the engineering community to remove those components of the centrifuge that were undamaged to the Davis campus and replace the drive system completely. The large centrifuge had cost over 2 million dollars to build, and it would have been irresponsible to simply scrap it. Recognizing this fact, funds were solicited and received from various sources, and Beam Engineering Inc. was contracted to design and construct the centrifuge at its new location. The University of California contributed a quarter of a million dollars and Tyndall Air Force Base, through Los Alamos National Laboratory, contributed $140,000. There were funds also contributed by LANL, LLNL, US Navy and NSF. The first stage in the phased development of the newly located centrifuge is nearing completion, which prompts the writing of this report. By the time that this report reaches the reader the first runs of the centrifuge will have been completed. The present report describes the present capability of the centrifuge and the plans for upgrading as time goes on. Several pilot studies were carried out. The experiments involved (1) the effects of nearby explosions on buried thin walled containers and (2) the advection and dispersion of toxic waste water through soils.

  17. DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage

    SciTech Connect (OSTI)

    Marchetti, Francesco; Marchetti, Francesco; Wryobek, Andrew J

    2008-02-21

    The post-meiotic phase of mouse spermatogenesis (spermiogenesis) is very sensitive to the genomic effects of environmental mutagens because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage. We hypothesized that repeated exposures to mutagens during this repair-deficient phase result in the accumulation of heritable genomic damage in mouse sperm that leads to chromosomal aberrations in zygotes after fertilization. We used a combination of single or fractionated exposures to diepoxybutane (DEB), a component of tobacco smoke, to investigate how differential DNA repair efficiencies during the three weeks of spermiogenesis affected the accumulation of DEB-induced heritable damage in early spermatids (21-15 days before fertilization, dbf), late spermatids (14-8 dbf) and sperm (7- 1 dbf). Analysis of chromosomalaberrations in zygotic metaphases using PAINT/DAPI showed that late spermatids and sperm are unable to repair DEB-induced DNA damage as demonstrated by significant increases (P<0.001) in the frequencies of zygotes with chromosomal aberrations. Comparisons between single and fractionated exposures suggested that the DNA repair-deficient window during late spermiogenesis may be less than two weeks in the mouse and that during this repair-deficient window there is accumulation of DNA damage in sperm. Finally, the dose-response study in sperm indicated a linear response for both single and repeated exposures. These findings show that the differential DNA repair capacity of post-meioitic male germ cells has a major impact on the risk of paternally transmitted heritable damage and suggest that chronic exposures that may occur in the weeks prior to fertilization because of occupational or lifestyle factors (i.e, smoking) can lead to an accumulation of genetic damage in sperm and result in heritable chromosomal aberrations of paternal origin.

  18. DNA Repair Decline During Mouse Spermiogenesis Results in the Accumulation of Heritable DNA Damage

    SciTech Connect (OSTI)

    Marchetti, Francesco; Marchetti, Francesco; Wyrobek, Andrew J.

    2007-12-01

    The post-meiotic phase of mouse spermatogenesis (spermiogenesis) is very sensitive to the genomic effects of environmental mutagens because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage. We hypothesized that repeated exposures to mutagens during this repair-deficient phase result in the accumulation of heritable genomic damage in mouse sperm that leads to chromosomal aberrations in zygotes after fertilization. We used a combination of single or fractionated exposures to diepoxybutane (DEB), a component of tobacco smoke, to investigate how differential DNA repair efficiencies during the three weeks of spermiogenesis affected the accumulation of DEB-induced heritable damage in early spermatids (21-15 days before fertilization, dbf), late spermatids (14-8 dbf) and sperm (7-1 dbf). Analysis of chromosomal aberrations in zygotic metaphases using PAINT/DAPI showed that late spermatids and sperm are unable to repair DEB-induced DNA damage as demonstrated by significant increases (P<0.001) in the frequencies of zygotes with chromosomal aberrations. Comparisons between single and fractionated exposures suggested that the DNA repair-deficient window during late spermiogenesis may be less than two weeks in the mouse and that during this repair-deficient window there is accumulation of DNA damage in sperm. Finally, the dose-response study in sperm indicated a linear response for both single and repeated exposures. These findings show that the differential DNA repair capacity of post-meioitic male germ cells has a major impact on the risk of paternally transmitted heritable damage and suggest that chronic exposures that may occur in the weeks prior to fertilization because of occupational or lifestyle factors (i.e, smoking) can lead to an accumulation of genetic damage in sperm and result in heritable chromosomal aberrations of paternal origin.

  19. Flavour symmetry breaking in the kaon parton distribution amplitude

    SciTech Connect (OSTI)

    Shi, Chao [Nanjing Univ. (China). Key Lab. of Modern Acoustics and Dept. of Physics.; Chang, Lei [Univ. of Adelaide, Adelaide (Australia). School of Chemistry and Physics.; Roberts, Craig D. [Argonne National Lab., Argonne, IL (United States). Physics Div.; Schmidt, Sebastian M. [Forschungszentrum Julich and JARA, Julich (Germany). Inst. for Advanced Simulation.; Tandy, Peter C. [Kent State Univ., Kent, OH (United States). Center for Nuclear Research.; Zong, Hong -shi [Nanjing Univ. (China). Key Lab. of Modern Acoustics; Institute of Theoretical Physics, Beijing (China). State Key Lab. of Theoretical Physics; Nuclear Physics and Cosmology, Nanjing (China). Joint Center for Particle.

    2014-11-01

    We compute the kaon's valence-quark (twist-two parton) distribution amplitude (PDA) by projecting its Poincaré-covariant Bethe–Salpeter wave-function onto the light-front. At a scale ? = 2 GeV, the PDA is a broad, concave and asymmetric function, whose peak is shifted 12–16% away from its position in QCD's conformal limit. These features are a clear expression of SU(3)-flavour-symmetry breaking. They show that the heavier quark in the kaon carries more of the bound-state's momentum than the lighter quark and also that emergent phenomena in QCD modulate the magnitude of flavour-symmetry breaking: it is markedly smaller than one might expect based on the difference between light-quark current masses. Our results add to a body of evidence which indicates that at any energy scale accessible with existing or foreseeable facilities, a reliable guide to the interpretation of experiment requires the use of such nonperturbatively broadened PDAs in leading-order, leading-twist formulae for hard exclusive processes instead of the asymptotic PDA associated with QCD's conformal limit. We illustrate this via the ratio of kaon and pion electromagnetic form factors: using our nonperturbative PDAs in the appropriate formulae, FK/F?=1.23 at spacelike-Q2=17 GeV2, which compares satisfactorily with the value of 0.92(5) inferred in e+e- annihilation at s=17 GeV2.

  20. HANFORD SITE LOW EXPOSURE PIPELINE REPAIR USING A NON-METALLIC COMPOSITE SYSTEM

    SciTech Connect (OSTI)

    HUTH RJ

    2009-11-12

    At the Department of Energy, Richland Operations (DOE-RL) Hanford site in eastern Washington, a 350 mm (14 inch) diameter high density polyethylene (HDPE) pump recirculation pipeline failed at a bonded joint adjacent to a radiologically and chemically contaminated groundwater storage basin. The responsible DOE-RL contractor, CH2MHill Plateau Remediation Company, applied a fiberglass reinforced plastic (composite) field repair system to the failed joint. The system was devised specifically for the HDPE pipe repair at the Hanford site, and had not been used on this type of plastic piping previously. This paper introduces the pipe failure scenario, describes the options considered for repair and discusses the ultimate resolution of the problem. The failed pipeline was successfully returned to service with minimal impact on waste water treatment plant operating capacity. Additionally, radiological and chemical exposures to facility personnel were maintained as low as reasonably achievable (ALARA). The repair is considered a success for the near term, and future monitoring will prove whether the repair can be considered for long term service and as a viable alternative for similar piping failures at the Hanford site.

  1. Symmetry Breaking Synchrony Breaking

    E-Print Network [OSTI]

    Darcy, Isabel K.

    Joints on Staffa near Mull ­ p. 9/4 #12;Columns along Snake River ­ p. 10/4 #12;Irish Giants Causeway ­ p/4 #12;Mud Plains ­ p. 3/4 #12;Leopard Spots ­ p. 4/4 #12;Sand Dunes in Namibian Desert ­ p. 5/4 #12 translation in one direction Sand dunes, zebra Spots: states centered at lattice points mud plains, leopard

  2. Instant uplifted inflation: A solution for a tension between inflation and SUSY breaking scale

    E-Print Network [OSTI]

    Yusuke Yamada

    2013-06-04

    The Hubble parameter during the inflationary era must be smaller than the gravitino mass if the moduli are stabilized by the Kachru-Kallosh-Linde-Trivedi mechanism. This condition represents the difficulty to combine the low scale SUSY breaking and the high scale inflation. We propose a simple mechanism which can naturally separate the inflation scale from the SUSY breaking scale today.

  3. Large-Scale Flow Response to the Breaking of Mountain Gravity Waves

    E-Print Network [OSTI]

    Lott, Francois

    Large-Scale Flow Response to the Breaking of Mountain Gravity Waves François Lott, LMD, Ecole and synoptic impacts of mountain gravity waves breaking observations Some diagnostics tools Parameterization in weather prediction and climate models 3) Interaction between a front and an idealised mountain massive

  4. Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities

    SciTech Connect (OSTI)

    Denholm, P.; Margolis, R. M.; Ong, S.; Roberts, B.

    2009-12-01

    Grid parity--or break-even cost--for photovoltaic (PV) technology is defined as the point where the cost of PV-generated electricity equals the cost of electricity purchased from the grid. Break-even cost is expressed in $/W of an installed system. Achieving break-even cost is a function of many variables. Consequently, break-even costs vary by location and time for a country, such as the United States, with a diverse set of resources, electricity prices, and other variables. In this report, we analyze PV break-even costs for U.S. residential customers. We evaluate some key drivers of grid parity both regionally and over time. We also examine the impact of moving from flat to time-of-use (TOU) rates, and we evaluate individual components of the break-even cost, including effect of rate structure and various incentives. Finally, we examine how PV markets might evolve on a regional basis considering the sensitivity of the break-even cost to four major drivers: technical performance, financing parameters, electricity prices and rates, and policies. We find that local incentives rather than ?technical? parameters are in general the key drivers of the break-even cost of PV. Additionally, this analysis provides insight about the potential viability of PV markets.

  5. Huliq:Breaking News Submit News Login Linear Nanotubes Offer Path To High-Performance Electronics

    E-Print Network [OSTI]

    Rogers, John A.

    Huliq:Breaking News Submit News Login Linear Nanotubes Offer Path To High-Performance Electronics.MoSys.com Page 1 of 2Linear nanotubes offer path to high-performance electronics | Huliq: Breaking News 3/28/2007http://www.huliq.com/16423/linear-nanotubes-offer-path-to-high-performance-electronics #12;compared

  6. Hydrogen bond breaking probed with multidimensional stimulated vibrational echo correlation spectroscopy

    E-Print Network [OSTI]

    Fayer, Michael D.

    Hydrogen bond breaking probed with multidimensional stimulated vibrational echo correlation September 2003 Hydrogen bond population dynamics are extricated with exceptional detail using ultrafast ( 50 of methanol­OD oligomers in CCl4 . Hydrogen bond breaking makes it possible to acquire data for times much

  7. GENTLE IONISATION AND VIOLENT BREAK-UP OF MOLECULES USING SOFT X-RAYS

    E-Print Network [OSTI]

    Bapat, Bhas

    RRCAT Indore, June 2012 BHAS BAPAT (PRL, AHMEDABAD) BREAK-UP OF MOLECULES USING SOFT X-RAYS RRCAT INDORE INVESTIGATED RECENT RESULTS BHAS BAPAT (PRL, AHMEDABAD) BREAK-UP OF MOLECULES USING SOFT X-RAYS RRCAT INDORE-UP OF MOLECULES USING SOFT X-RAYS RRCAT INDORE, JUNE 2012 3 / 27 #12;INTRODUCTION MOLECULES A molecule may

  8. Short communication A new breaking wave height direct estimator from video imagery

    E-Print Network [OSTI]

    Short communication A new breaking wave height direct estimator from video imagery Rafael Almar a, laborious and limited to short term and localized field observations car- ried out on an energetic bathymetry through depth- inversion algorithms, where wave celerities or a proxy for wave breaking energy

  9. Automatic coke oven heating control system at Burns Harbor for normal and repair operation

    SciTech Connect (OSTI)

    Battle, E.T.; Chen, K.L. [Bethlehem Steel Corp., Burns Harbor, IN (United States); [Bethlehem Steel Corp., PA (United States)

    1997-12-31

    An automatic heating control system for coke oven batteries was developed in 1985 for the Burns Harbor No. 1 battery and reported in the 1989 Ironmaking Conference Proceedings. The original system was designed to maintain a target coke temperature at a given production level under normal operating conditions. Since 1989, enhancements have been made to this control system so that it can also control the battery heating when the battery is under repair. The new control system has improved heating control capability because it adjusts the heat input to the battery in response to anticipated changes in the production schedule. During a recent repair of this 82 oven battery, the pushing schedule changed from 102 ovens/day to 88 ovens/day, then back to 102 ovens/day, then to 107 ovens/day. During this repair, the control system was able to maintain the coke temperature average standard deviation at 44 F, with a maximum 75 F.

  10. A survey of repair practices for nuclear power plant containment metallic pressure boundaries

    SciTech Connect (OSTI)

    Oland, C.B.; Naus, D.J.

    1998-05-01

    The Nuclear Regulatory Commission has initiated a program at the Oak Ridge National Laboratory to provide assistance in their assessment of the effects of potential degradation on the structural integrity and leaktightness of metal containment vessels and steel liners of concrete containments in nuclear power plants. One of the program objectives is to identify repair practices for restoring metallic containment pressure boundary components that have been damaged or degraded in service. This report presents issues associated with inservice condition assessments and continued service evaluations and identifies the rules and requirements for the repair and replacement of nonconforming containment pressure boundary components by welding or metal removal. Discussion topics include base and welding materials, welding procedure and performance qualifications, inspection techniques, testing methods, acceptance criteria, and documentation requirements necessary for making acceptable repairs and replacements so that the plant can be returned to a safe operating condition.

  11. Evaluation of bisphenol E cyanate ester for the resin-injection repair of advanced composites

    SciTech Connect (OSTI)

    Wilber Yaote Lio

    2009-12-19

    This thesis is a compilation of a general introduction and literature review that ties together the subsequent chapters which consist of two journal articles that have yet to be submitted for publication. The overall topic relates to the evaluation and application of a new class of cyanate ester resin with unique properties that lend it applicable to use as a resin for injection repair of high glass transition temperature polymer matrix composites. The first article (Chapter 2) details the evaluation and optimization of adhesive properties of this cyanate ester and alumina nanocomposites under different conditions. The second article (Chapter 3) describes the development and evaluation of an injection repair system for repairing delaminations in polymer matrix composites.

  12. Bosh repairs No. 3 blast furnace, Edgar Thomson Plant Mon Valley Works

    SciTech Connect (OSTI)

    Stoupis, M.G.

    1993-01-01

    The paper describes in detail the steps taken from quenching to dry out of the furnace to repair the bosh area of the No.3 blast furnace. Inspection of the area revealed that there was no brick anywhere in the bosh. Brick in the tuyere breast area had been peeled back to reveal the steel plate, and descaling revealed 14 pipes fully exposed. None were leaking, but one seemed badly deteriorated. Conventional repairs could not take place before the scheduled blow-in. Installation of coolers were instead tried.

  13. Treatment methods for breaking certain oil and water emulsions

    DOE Patents [OSTI]

    Sealock, Jr., L. John (W. Richland, WA); Baker, Eddie G. (Richland, WA); Elliott, Douglas C. (Richland, WA)

    1992-01-01

    Disclosed are treatment methods for breaking emulsions of petroleum oil and salt water, fatty oil and water, and those resulting from liquefication of organic material. The emulsions are broken by heating to a predetermined temperature at or above about 200.degree. C. and pressurizing to a predetermined pressure above the vapor pressure of water at the predetermined temperature to produce a heated and pressurized fluid. The heated and pressurized fluid is contained in a single vessel at the predetermined temperature and pressure for a predetermined period of time to effectively separate the emulsion into substantially distinct first and second phases, the first phase comprising primarily the petroleum oil, the second phase comprising primarily the water. The first and second phases are separately withdrawn from the vessel at a withdraw temperature between about 200.degree. C. and 374.degree. C. and a withdraw pressure above the vapor pressure of water at the withdraw temperature. Where solids are present in the certain emulsions, the above described treatment may also effectively separate the certain emulsion into a substantially distinct third phase comprising primarily the solids.

  14. Scales of Fermion Mass Generation and Electroweak Symmetry Breaking

    E-Print Network [OSTI]

    Duane A. Dicus; Hong-Jian He

    2005-06-11

    The scale of mass generation for fermions (including neutrinos) and the scale for electroweak symmetry breaking (EWSB) can be bounded from above by the unitarity of scattering involving longitudinal weak gauge bosons or their corresponding would-be Goldstone bosons. Including the exact n-body phase space we analyze the 2 --> n ($n \\geq 2$) processes for the fermion-(anti)fermion scattering into multiple gauge boson final states. Contrary to naive energy power counting, we demonstrate that as $n$ becomes large, the competition between an increasing energy factor and a phase-space suppression leads to a {\\it strong new upper bound} on the scale of fermion mass generation at a finite value $n=n_s$, which is {\\it independent of the EWSB scale,} $v = (\\sqrt{2}G_F)^{-1/2}$. For quarks, leptons and Majorana neutrinos, the strongest 2 --> n limits range from about 3TeV to 130-170TeV (with $2\\lesssim n_s \\lesssim 24$), depending on the measured fermion masses. Strikingly, given the tiny neutrino masses as constrained by the neutrino oscillations, neutrinoless double-beta decays and astrophysical observations, the unitarity violation of $\

  15. Path integrals and symmetry breaking for optimal control theory

    E-Print Network [OSTI]

    H. J. Kappen

    2005-10-07

    This paper considers linear-quadratic control of a non-linear dynamical system subject to arbitrary cost. I show that for this class of stochastic control problems the non-linear Hamilton-Jacobi-Bellman equation can be transformed into a linear equation. The transformation is similar to the transformation used to relate the classical Hamilton-Jacobi equation to the Schr\\"odinger equation. As a result of the linearity, the usual backward computation can be replaced by a forward diffusion process, that can be computed by stochastic integration or by the evaluation of a path integral. It is shown, how in the deterministic limit the PMP formalism is recovered. The significance of the path integral approach is that it forms the basis for a number of efficient computational methods, such as MC sampling, the Laplace approximation and the variational approximation. We show the effectiveness of the first two methods in number of examples. Examples are given that show the qualitative difference between stochastic and deterministic control and the occurrence of symmetry breaking as a function of the noise.

  16. Lyman-break galaxies are they young spheroids?

    E-Print Network [OSTI]

    Matteucci, F

    2002-01-01

    We have compared the results from a model for the chemical evolution of an elliptical galaxy with initial luminous mass of 2x10^10 M_sun and effective radius of 2 kpc with the recent abundance determinations for the Lyman-break galaxy MS 1512-cB58 at a redshift z=2.7276. After correcting the iron abundance determination for the presence of dust we concluded that the observed [Si/Fe], [Mg/Fe], [N/Fe] are consistent with our model when a galactic age between 20 and 35 Myr is assumed. Moreover, the [N/O] ratio also suggests the same age. This age is in very good agreement with other independent studies based on the analysis of the spectral energy distribution suggesting that this object is younger than 35 Myr. Therefore, we suggest that MS 1512-cB58 is a truly young normal elliptical galaxy experiencing its main episode of star formation and galactic wind.

  17. Mitral Web -A New Concept for Mitral Valve Repair: Improved Engineering Design and In-Vitro Studies

    E-Print Network [OSTI]

    Pekkan, Kerem

    Mitral Web - A New Concept for Mitral Valve Repair: Improved Engineering Design and In of Biomedical Engineering, Georgia Institute of Technology, GA, USA Myxomatous mitral valve disease is currently reported that mitral valve repair is preferable to valve replace- ment, as it offers certain advantages

  18. Restoration and repair of 30-year old cooling towers at the Paducah Gaseous Diffusion Plant, Phase I. Draft 1

    SciTech Connect (OSTI)

    Shelton, M.F.

    1985-01-01

    Early in 1980, a comprehensive reliability study was made to ascertain the ability of the present 30-year old recirculating water system to meet the anticipated load demand through the year 2000. The findings and recommendations of this study were used as a guide to schedule uprating and repairs. This paper deals with the underground distribution system and cooling tower repairs.

  19. Odd-Parity Superconductivity in the Vicinity of Inversion Symmetry Breaking in Spin-Orbit-Coupled Systems

    E-Print Network [OSTI]

    Kozii, Vladyslav

    We study superconductivity in spin-orbit-coupled systems in the vicinity of inversion symmetry breaking. We find that, because of the presence of spin-orbit coupling, fluctuations of the incipient parity-breaking order ...

  20. Hot repair of ceramic burner on hot blast stoves at USS/Kobe`s {number_sign}3 blast furnace

    SciTech Connect (OSTI)

    Bernarding, T.F.; Chemorov, M.; Shimono, S.; Phillips, G.R.

    1997-12-31

    During the 1992 reline of the No. 3 blast furnace, three new stoves were constructed. The design of the stoves, equipped with internal ceramic burners, was for providing a hot blast temperature of 2,000 F at a wind rate of 140,000 SCFM. After 3 years the performance had deteriorated so the burners were cleaned. When a second cleaning did not improve the performance of No. 3 blast furnace, it was decided to repair the refractory while still hot. The paper describes the hot repair procedures, taking a stove off for repairs, maintenance heat up during repairs, two stove operation, stove commissioning, repair of a ceramic burner, and wet gas prevention.

  1. Particle-Hole Symmetry Breaking in the Pseudogap State of Bi2201

    SciTech Connect (OSTI)

    Hashimoto, M.; /SIMES, Stanford /Stanford U., Geballe Lab. /LBNL, ALS; He, R.-H.; /aff SIMES, Stanford /Stanford U., Geballe Lab.; Tanaka, K.; /aff SIMES, Stanford /Stanford U., Geballe Lab. /LBNL, ALS /Osaka U.; Testaud, J.P.; /SIMES, Stanford /Stanford U., Geballe Lab. /LBNL, ALS; Meevasana1, W.; Moore, R.G.; Lu, D.H.; /SIMES, Stanford /Stanford U., Geballe Lab.; Yao, H.; /SIMES, Stanford; Yoshida, Y.; Eisaki, H.; /AIST, Tsukuba; Devereaux, T.P.; /SIMES, Stanford /Stanford U., Geballe Lab.; Hussain, Z.; /LBNL, ALS; Shen, Z.-X.; /SIMES, Stanford /Stanford U., Geballe Lab.

    2011-08-19

    In conventional superconductors, a gap exists in the energy absorption spectrum only below the transition temperature (T{sub c}), corresponding to the energy price to pay for breaking a Cooper pair of electrons. In high-T{sub c} cuprate superconductors above T{sub c}, an energy gap called the pseudogap exists, and is controversially attributed either to pre-formed superconducting pairs, which would exhibit particle-hole symmetry, or to competing phases which would typically break it. Scanning tunnelling microscopy (STM) studies suggest that the pseudogap stems from lattice translational symmetry breaking and is associated with a different characteristic spectrum for adding or removing electrons (particle-hole asymmetry). However, no signature of either spatial or energy symmetry breaking of the pseudogap has previously been observed by angle-resolved photoemission spectroscopy (ARPES). Here we report ARPES data from Bi2201 which reveals both particle-hole symmetry breaking and dramatic spectral broadening indicative of spatial symmetry breaking without long range order, upon crossing through T* into the pseudogap state. This symmetry breaking is found in the dominant region of the momentum space for the pseudogap, around the so-called anti-node near the Brillouin zone boundary. Our finding supports the STM conclusion that the pseudogap state is a broken-symmetry state that is distinct from homogeneous superconductivity.

  2. DNA repair efficiency in germ cells and early mouse embryos and consequences for radiation-induced transgenerational genomic damage

    SciTech Connect (OSTI)

    Marchetti, Francesco; Wyrobek, Andrew J.

    2009-01-18

    Exposure to ionizing radiation and other environmental agents can affect the genomic integrity of germ cells and induce adverse health effects in the progeny. Efficient DNA repair during gametogenesis and the early embryonic cycles after fertilization is critical for preventing transmission of DNA damage to the progeny and relies on maternal factors stored in the egg before fertilization. The ability of the maternal repair machinery to repair DNA damage in both parental genomes in the fertilizing egg is especially crucial for the fertilizing male genome that has not experienced a DNA repair-competent cellular environment for several weeks prior to fertilization. During the DNA repair-deficient period of spermatogenesis, DNA lesions may accumulate in sperm and be carried into the egg where, if not properly repaired, could result in the formation of heritable chromosomal aberrations or mutations and associated birth defects. Studies with female mice deficient in specific DNA repair genes have shown that: (i) cell cycle checkpoints are activated in the fertilized egg by DNA damage carried by the sperm; and (ii) the maternal genotype plays a major role in determining the efficiency of repairing genomic lesions in the fertilizing sperm and directly affect the risk for abnormal reproductive outcomes. There is also growing evidence that implicates DNA damage carried by the fertilizing gamete as a mediator of postfertilization processes that contribute to genomic instability in subsequent generations. Transgenerational genomic instability most likely involves epigenetic mechanisms or error-prone DNA repair processes in the early embryo. Maternal and embryonic DNA repair processes during the early phases of mammalian embryonic development can have far reaching consequences for the genomic integrity and health of subsequent generations.

  3. The effects of similarity breaking on the intracluster medium

    E-Print Network [OSTI]

    E. J. Lloyd-Davies; R. G. Bower; T. J. Ponman

    2002-03-28

    We construct a family of simple analytical models of galaxy clusters at the present epoch and compare its predictions with observational data. We explore two processes that break the self-similarity of galaxy clusters: systematic variation in the dark matter halo concentration and energy injection into the intracluster gas, through their effects on the observed cluster properties. Three observed relations between cluster properties and temperature are employed to constrain the model; mass, slope of gas density profile (beta) and luminosity. The slope of the mass-temperature relation is found to be reproduced by our model when the observed variation in concentration is included, raising the slope from the self-similar prediction of 1.5, to that of the observed relation, ~ 2. Heating of the gas is observed to have little effect on the mass-temperature relation. The mean trend in the beta-temperature relation is reproduced by energy injection of 0.5-0.75 keV per particle, while concentration variation has only a small effect. Excess energies calculated for individual systems from the beta-temperature relation suggest that the lowest mass systems may have excess energies that are biased to lower values by selection effects. The observed properties of the luminosity-temperature relation are reproduced by the combined effects of excess energy and a trend in the dark matter concentration. At high masses the observed variation in dark matter concentration results a slope of ~ 2.7 compared to recent observations in the range 2.6-2.9, whilst the observed steepening in galaxy groups is predicted when heating of 0.5-0.75 keV per particle is included. Hence a combination of energy injection and dark matter concentration variation appears able to account for the mean trends in the observed relations.

  4. Moduli stabilization, F-term uplifting and soft supersymmetry breaking terms

    E-Print Network [OSTI]

    Hiroyuki Abe; Tetsutaro Higaki; Tatsuo Kobayashi; Yuji Omura

    2007-01-21

    We study moduli stabilization with F-term uplifting. As a source of uplifting F-term, we consider spontaneous supersymmetry breaking models, e.g. the Polonyi model and the Intriligator-Seiberg-Shih model. We analyze potential minima by requiring almost vanishing vacuum energy and evaluate the size of modulus F-term. We also study soft SUSY breaking terms. In our scenario, the mirage mediation is dominant in gaugino masses. Scalar masses can be comparable with gaugino masses or much heavier, depending on couplings with spontaneous supersymmetry breaking sector.

  5. Dependability Modelling of Repairable Systems using Bayesian Networks Martin Neil *, David Marquez**

    E-Print Network [OSTI]

    Neil, Martin

    : We present a Hybrid Bayesian Network (HBN) framework to model the availability of renewable systems repair (renewal) distributions might be modelled using HBNs. Keywords: Bayesian Networks; Bayesian systems represented by a series of models each designed to model distinct stages in the renewal process

  6. Fast Interactive Simulations of Mitral Valve Repair Neil A. Tenenholtz, Peter E. Hammer, Robert D. Howe

    E-Print Network [OSTI]

    Fast Interactive Simulations of Mitral Valve Repair Neil A. Tenenholtz, Peter E. Hammer, Robert D. Howe Keywords: Surgical simulation, human-computer interaction, haptics, mitral valve, cardiac surgery. I. Problem Solved A healthy mitral valve ensures the one-way flow of oxygenated blood from the left

  7. Development/Plasticity/Repair The Bone Morphogenetic Protein Roof Plate Chemorepellent

    E-Print Network [OSTI]

    Butler, Samantha

    Development/Plasticity/Repair The Bone Morphogenetic Protein Roof Plate Chemorepellent Regulates, Toronto, Ontario, Canada M5G 1X8 Commissural spinal axons extend away from the roof plate (RP) in response to the dorsal midline and are generated by the bone morphogenetic proteins (BMPs) in the roof plate (RP) (Liem

  8. Model Repair --Aligning Process Models to Reality Dirk Fahland, Wil M.P. van der Aalst

    E-Print Network [OSTI]

    van der Aalst, Wil

    discovery and (2) conformance checking. Process discovery techniques automatically construct a process model an existing process model does not conform to reality one could -- in principle -- use process discoveryModel Repair -- Aligning Process Models to Reality Dirk Fahland, Wil M.P. van der Aalst Eindhoven

  9. FFaacciilliittiieess MMaannaaggeemmeenntt//EEnnvviirroonnmmeennttaall HHeeaalltthh && SSaaffeettyy Hazardous Work Area/Equipment Repair Form

    E-Print Network [OSTI]

    Mojzsis, Stephen J.

    Hazardous Work Area/Equipment Repair Form Form Instructions: Client is responsible for completing this form to assure that equipment and/or immediate work areas are not contaminated with any hazardous materials, tissue, etc.) Do Safety Hazards exist in the work area? N ___ Y ___ (Electrical, burn, or trip hazards

  10. Development/Plasticity/Repair Dendritic Spine Dynamics Regulate the Long-Term Stability

    E-Print Network [OSTI]

    van Rossum, Mark

    Development/Plasticity/Repair Dendritic Spine Dynamics Regulate the Long-Term Stability of Synaptic Plasticity Cian O'Donnell,1,2 Matthew F. Nolan,3 and Mark C. W. van Rossum1 1Institute for Adaptive of Edinburgh, Edinburgh EH8 9XD, United Kingdom Long-term synaptic plasticity requires postsynaptic influx

  11. Development/Plasticity/Repair Dendritic BDNF Synthesis Is Required for Late-Phase Spine

    E-Print Network [OSTI]

    Stryker, Michael

    Development/Plasticity/Repair Dendritic BDNF Synthesis Is Required for Late-Phase Spine Maturation paradigm for experience-dependent cortical development is called ocular dominance (OD) plasticity, where closing one eye for a few days during a critical period of heightened plasticity leads to marked decrease

  12. Development/Plasticity/Repair Wiring Stability of the Adult Drosophila Olfactory Circuit

    E-Print Network [OSTI]

    Luo, Liqun

    Development/Plasticity/Repair Wiring Stability of the Adult Drosophila Olfactory Circuit after Institute of Molecular Pathology, 1030 Vienna, Austria Neuronal wiring plasticity in response to experience. Here, we assess wiring plasticity in a discrete neural map represented by the adult Drosophila

  13. Development/Plasticity/Repair Dark Exposure Extends the Integration Window for

    E-Print Network [OSTI]

    Lee, Hey-Kyoung

    Development/Plasticity/Repair Dark Exposure Extends the Integration Window for Spike-Timing-Dependent Plasticity Yatu Guo,1,2 Shiyong Huang,1 Roberto de Pasquale,1 Kevin McGehrin,4 Hey-Kyoung Lee,1,3,4 Kanxing-timing-dependent plasticity, in which the polarity of plasticity is determined not by the stimulationfrequency

  14. Development/Plasticity/Repair Simultaneous NMDA-Dependent Long-Term Potentiation of

    E-Print Network [OSTI]

    Segal, Menahem

    Development/Plasticity/Repair Simultaneous NMDA-Dependent Long-Term Potentiation of EPSCs and Long activity-dependent long-term plasticity of neuronal networks is the interplay between excitatory, whereas a nitric oxide synthase inhibitor was ineffec- tive. Finally, network-induced plasticity

  15. Development/Plasticity/Repair STAT1 Regulates the Homeostatic Component of Visual

    E-Print Network [OSTI]

    Sur, Mriganka

    Development/Plasticity/Repair STAT1 Regulates the Homeostatic Component of Visual Cortical Plasticity via an AMPA Receptor-Mediated Mechanism Ikue Nagakura, Audra Van Wart, Jeremy Petravicz, Daniela signaling in neuronal function; however, its role in experience-dependent plasticity is unknown. Here we

  16. Toward a State of Good Repair for Railroad Bridges through Structural Health Monitoring

    E-Print Network [OSTI]

    Bustamante, Fabián E.

    Toward a State of Good Repair for Railroad Bridges through Structural Health Monitoring NUTC of this research is to add a new tool to the asset management toolbox: structural health monitoring, particularly is Structural Health Monitoring (SHM)? SHM is process of intelligently collecting data from sensors on critical

  17. Multilayer sulfur-resistant composite metal membranes and methods of making and repairing the same

    DOE Patents [OSTI]

    Way, J. Douglas; Hatlevik, Oyvind

    2014-07-15

    The invention relates to thin, hydrogen-permeable, sulfur-resistant membranes formed from multi-layers of palladium or palladium-alloy coatings on porous, ceramic or metal supports, methods of making these membranes, methods of repairing layers of these membranes and devices that incorporate these membranes.

  18. Development/Plasticity/Repair The ERK2 Mitogen-Activated Protein Kinase Regulates the

    E-Print Network [OSTI]

    Development/Plasticity/Repair The ERK2 Mitogen-Activated Protein Kinase Regulates the Timing Oligodendrocytedevelopmentistightlycontrolledbyavarietyofextracellulargrowthanddifferentiationfactors.Themitogen-activated protein kinases (MAPKs), ERK1 and ERK2, are critical intracellular signaling (ERKs) are ubiquitously expressed, coordinately regulated, and highly similar, but Erk2 deletion in mice

  19. Development/Plasticity/Repair Phosphatidylinositol 3-Kinase Activates ERK in Primary

    E-Print Network [OSTI]

    Clapham, David E.

    Development/Plasticity/Repair Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory activation to inflammatory pain. We further investigated the correlationbetweenthePI3KandtheERK294002 and wortmannin, indicative of the activation of PI3K by both agents. ERK activation by capsaicin

  20. Is the Cure Worse Than the Disease? Overfitting in Automated Program Repair

    E-Print Network [OSTI]

    Brun, Yuriy

    Is the Cure Worse Than the Disease? Overfitting in Automated Program Repair Edward K. Smith Earl T techniques validate patch correctness with respect to user-provided or inferred contracts [24 undertested functionality. Permission to make digital or hard copies of all or part of this work for personal

  1. Is the Cure Worse Than the Disease? Overfitting in Automated Program Repair

    E-Print Network [OSTI]

    Fernandez, Thomas

    Is the Cure Worse Than the Disease? Overfitting in Automated Program Repair Edward K. Smith Earl T-provided or inferred contracts [26,46,60], a larger proportion use test cases. Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided

  2. Metal inhibition of human alkylpurine-DNA-N-glycosylase activity in base excision repair

    E-Print Network [OSTI]

    Wang, Ping; Guliaev, Anton B.; Hang, Bo

    2006-01-01

    0.38 nM ) Zn 2+ Cd 2 + Metal ion (µM) Product % Relativeof hAPE1 Zn 2 + Cd 2 + Metal ion (µM) Figure 6 Figure 7Interactions by carcinogenic metal compounds with DNA repair

  3. Development/Plasticity/Repair NG2 Glia Generate New Oligodendrocytes But Few

    E-Print Network [OSTI]

    Richardson, William D.

    Development/Plasticity/Repair NG2 Glia Generate New Oligodendrocytes But Few Astrocytes in a Murine-derived growth factor receptor subunit (PDGFRA) and the NG2 proteoglycan. These "NG2 cells" descend from and white matter of the postnatal brain. It has been proposed that NG2 cells can also

  4. The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber Assembly

    E-Print Network [OSTI]

    Mecham, Robert

    The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber Assembly Adrian Shifren and Robert P properties of the lung are largely determined by the connective tissue networks laid down during development. The macromolecules most important for lung mechanics and structural integrity are collagen, elastin

  5. A New Rhenanite ( -NaCaPO4) and Hydroxyapatite Biphasic Biomaterial for Skeletal Repair

    E-Print Network [OSTI]

    Tas, A. Cuneyt

    A New Rhenanite ( -NaCaPO4) and Hydroxyapatite Biphasic Biomaterial for Skeletal Repair Sahil Abstract: Biphasic -rhenanite ( -NaCaPO4)­hydroxyapatite (Ca10(PO4)6(OH)2) biomaterials were prepared% rhenanite) biomaterials, while retaining their submicron particle sizes and high surface areas. -rhenanite

  6. Accepting Failure: Availability through Repair-centric System Design Aaron Brown

    E-Print Network [OSTI]

    California at Berkeley, University of

    1 Accepting Failure: Availability through Repair-centric System Design Aaron Brown Qualifying Exam Proposal 3 April 2001 Abstract Motivated by the lack of rapid improvement in the availability of Internet server systems, we introduce a new philosophy for designing highly-available systems that better reflects

  7. Development/Plasticity/Repair A Specific Requirement of Arc/Arg3.1 for Visual

    E-Print Network [OSTI]

    Lee, Hey-Kyoung

    Development/Plasticity/Repair A Specific Requirement of Arc/Arg3.1 for Visual Experience-Induced Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex Ming Gao,1 Kenneth Sossa,1 Lihua Song,1 Lauren.OurresultsdemonstratethatArc/Arg3.1playsaselectiveroleinregulatingvisualexperience-dependent homeostatic plasticity of excitatory

  8. Development/Plasticity/Repair Hair Cell Replacement in Adult Mouse Utricles after

    E-Print Network [OSTI]

    Rubel, Edwin

    Development/Plasticity/Repair Hair Cell Replacement in Adult Mouse Utricles after Targeted Ablation of Hair Cells with Diphtheria Toxin Justin S. Golub,1 Ling Tong,1 Tot B. Ngyuen,1 Cliff R. Hume,1 Richard utricle by inserting the human diphtheria toxin receptor (DTR) gene into the Pou4f3 gene, which encodes

  9. Overview of NCHRP Design Guideline for EPS-Block Geofoam in Slope Stabilization and Repair

    E-Print Network [OSTI]

    Manhattan College Bronx, New York 10471 Tel: (718) 826-7177 E-mail: john.horvath@manhattan.edu Dov and repair applications based on the results of National Cooperative Highway Research Program (NCHRP) Project was performed under NCHRP Project 24-11(01) and produced a design guideline for use of EPS blocks in stand

  10. Nucleolar exit of RNF8 and BRCA1 in response to DNA damage

    SciTech Connect (OSTI)

    Guerra-Rebollo, Marta; Mateo, Francesca; Franke, Kristin; Huen, Michael S.Y.; Lopitz-Otsoa, Fernando; Rodriguez, Manuel S.; Plans, Vanessa; Thomson, Timothy M.

    2012-11-01

    The induction of DNA double-strand breaks (DSBs) elicits a plethora of responses that redirect many cellular functions to the vital task of repairing the injury, collectively known as the DNA damage response (DDR). We have found that, in the absence of DNA damage, the DSB repair factors RNF8 and BRCA1 are associated with the nucleolus. Shortly after exposure of cells to {gamma}-radiation, RNF8 and BRCA1 translocated from the nucleolus to damage foci, a traffic that was reverted several hours after the damage. RNF8 interacted through its FHA domain with the ribosomal protein RPSA, and knockdown of RPSA caused a depletion of nucleolar RNF8 and BRCA1, suggesting that the interaction of RNF8 with RPSA is critical for the nucleolar localization of these DDR factors. Knockdown of RPSA or RNF8 impaired bulk protein translation, as did {gamma}-irradiation, the latter being partially countered by overexpression of exogenous RNF8. Our results suggest that RNF8 and BRCA1 are anchored to the nucleolus through reversible interactions with RPSA and that, in addition to its known functions in DDR, RNF8 may play a role in protein synthesis, possibly linking the nucleolar exit of this factor to the attenuation of protein synthesis in response to DNA damage. -- Highlights: Black-Right-Pointing-Pointer RNF8 and BRCA1 are associated with the nucleolus of undamaged cells. Black-Right-Pointing-Pointer Upon {gamma}-radiation, RNF8 and BRCA1 are translocated from the nucleolus to damage foci. Black-Right-Pointing-Pointer The ribosomal protein RPSA anchors RNF8 to the nucleolus. Black-Right-Pointing-Pointer RNF8 may play previously unsuspected roles in protein synthesis.

  11. Persistence of gamma-H2AX and 53BP1 foci in proliferating and nonproliferating human mammary epithelial cells after exposure to gamma-rays or iron ions

    SciTech Connect (OSTI)

    Groesser, Torsten; Chang, Hang; Fontenay, Gerald; Chen, James; Costes, Sylvain V.; Barcellos-Hoff, Mary Helen; Parvin, Bahram; Rydberg, Bjorn

    2010-12-22

    To investigate {gamma}-H2AX (phosphorylated histone H2AX) and 53BP1 (tumour protein 53 binding protein No. 1) foci formation and removal in proliferating and non-proliferating human mammary epithelial cells (HMEC) after exposure to sparsely and densely ionizing radiation under different cell culture conditions. HMEC cells were grown either as monolayers (2D) or in extracellular matrix to allow the formation of acinar structures in vitro (3D). Foci numbers were quantified by image analysis at various time points after exposure. Our results reveal that in non-proliferating cells under 2D and 3D cell culture conditions, iron-ion induced {gamma}-H2AX foci were still present at 72 h after exposure, although 53BP1 foci returned to control levels at 48 h. In contrast in proliferating HMEC, both {gamma}-H2AX and 53BP1 foci decreased to control levels during the 24-48 h time interval after irradiation under 2D conditions. Foci numbers decreased faster after {gamma}-ray irradiation and returned to control levels by 12 h regardless of marker, cell proliferation status, and cell culture condition. Conclusions: The disappearance of radiation induced {gamma}-H2AX and 53BP1 foci in HMEC have different dynamics that depend on radiation quality and proliferation status. Notably, the general patterns do not depend on the cell culture condition (2D versus 3D). We speculate that the persistent {gamma}-H2AX foci in iron-ion irradiated non-proliferating cells could be due to limited availability of double strand break (DSB) repair pathways in G0/G1-phase, or that repair of complex DSB requires replication or chromatin remodeling.

  12. Wave breaking over sloping beaches using a coupled boundary integral-level set method

    SciTech Connect (OSTI)

    Garzon, M.; Adalsteinsson, D.; Gray, L.; Sethian, J.A.

    2003-12-08

    We present a numerical method for tracking breaking waves over sloping beaches. We use a fully non-linear potential model for in-compressible, irrotational and inviscid flow, and consider the effects of beach topography on breaking waves. The algorithm uses a Boundary Element Method (BEM) to compute the velocity at the interface, coupled to a Narrow Band Level Set Method to track the evolving air/water interface, and an associated extension equation to update the velocity potential both on and off the interface. The formulation of the algorithm is applicable to two and three dimensional breaking waves; in this paper, we concentrate on two-dimensional results showing wave breaking and rollup, and perform numerical convergence studies and comparison with previous techniques.

  13. TRAC-PD2 modeling of LOFT and PWR small cold-leg breaks

    SciTech Connect (OSTI)

    Knight, T.D.; Willcutt, G.J.E. Jr.; Lime, J.F.

    1981-01-01

    The Transient Reactor Analysis Code (TRAC) is being developed at the Los Alamos National Laboratory to provide advanced best-estimate predictions of postulated accidents in light-water reactors. TRAC-PD2, the latest publicly released version of the code, is currently being tested against small-break and other transients in experimental facilities; it is also being used to analyze postulated accidents in commercial power reactors. Calculated results for LOFT small-break experiments are compared to data, and the results from two small-break calculations for two different reactor systems are presented. It is concluded that TRAC-PD2 is useful for the analysis of cold-leg small-break accidents.

  14. Design Considerations for Monopile Founded Offshore Wind Turbines Subject to Breaking Waves 

    E-Print Network [OSTI]

    Owens, Garrett Reese 1987-

    2012-11-26

    The majority of offshore wind farms utilize monopile substructures. As these wind farms are typically located in water depths less than 30 meters, the effect of breaking waves on these structures is of great concern to design engineers...

  15. Largest Federally Owned Wind Farm Breaks Ground at U.S. Weapons...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Largest Federally Owned ... Largest Federally Owned Wind Farm Breaks Ground at U.S. Weapons Facility Posted: August 13, 2013 - 12:01pm WASHINGTON - Building on President Obama's...

  16. Introduction of Break-Out Session at the International PV Module Quality Assurance Forum (Presentation)

    SciTech Connect (OSTI)

    Kurtz, S.; Wohlgemuth, J.; Yamamichi, M.; Sample, T.

    2011-07-01

    This presentation outlines review requirements for quality assurance (QA) rating systems, logical design of QA systems, and specific tasks for break-out session 1 of the 2011 International PV Module Quality Assurance Forum.

  17. Nonequilibrium superconducting thin films with sub-gap and pair-breaking photon illumination

    E-Print Network [OSTI]

    Guruswamy, T.; Goldie, D. J.; Withington, S.

    2015-04-08

    We calculate nonequilibrium quasiparticle and phonon distributions for a number of widely-used low transition temperature thin-film superconductors under constant, uniform illumination by sub-gap probe and pair-breaking signal photons simultaneously...

  18. Photo of the Week: Record-Breaking Solar Cells | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    Solar Junction, in partnership with NREL, has developed solar cells that reach a record-breaking 44 percent efficiency -- meaning that more than 40 percent of the sunlight the...

  19. Polar Kerr Effect and Time Reversal Symmetry Breaking in Bilayer Graphene

    E-Print Network [OSTI]

    Nandkishore, Rahul Mahajan

    The unique sensitivity of optical response to different types of symmetry breaking can be used to detect and identify spontaneously ordered many-body states in bilayer graphene. We predict a strong response at optical ...

  20. Physics and learning based computational models for breaking bow waves based on new boundary immersion approaches

    E-Print Network [OSTI]

    Weymouth, Gabriel David

    2008-01-01

    A ship moving on the free surface produces energetic breaking bow waves which generate spray and air entrainment. Present experimental, analytic, and numerical studies of this problem are costly, inaccurate and not robust. ...

  1. The Nature of the Far-UV Break in the Energy Distribution of Quasars

    E-Print Network [OSTI]

    L. Binette; S. Haro-Corzo; Y. Krongold; A. C. Andersen

    2007-06-13

    A prominent continuum steepening is observed in quasar energy distributions near 1100A. We review possible interpretations for the physical origin of this so-called far-UV break.

  2. Simulation of a small break loss of coolant accident conducted at the BETHSY Integral Test Facility 

    E-Print Network [OSTI]

    Bott, Charles Patrick

    1992-01-01

    systems where the interaction mechanisms themselves are complex and contain uncertainties. Early analysis of reactor accidents concentrated on severe accident scenarios in- volving large piping ruptures in the coolant system. These were seen... as the design basis accident for the systems, since, if the system could survive such a, scenario and maintain fuel cladding integrity, any smaller piping break would be a less severe ac- cident of one already evaluated. The duration of these large break loss...

  3. Spontaneous breaking of SU(3) to finite family symmetries: a pedestrian's approach

    E-Print Network [OSTI]

    Christoph Luhn

    2011-01-12

    Non-Abelian discrete family symmetries play a pivotal role in the formulation of models with tri-bimaximal lepton mixing. We discuss how to obtain symmetries such as A4, semidirect product of Z7 and Z3, and Delta(27) from an underlying SU(3) gauge symmetry. Higher irreducible representations are required to achieve the spontaneous breaking of the continuous group. We present methods of identifying the required vacuum alignments and discuss in detail the symmetry breaking potentials.

  4. On the local properties of highly nonlinear unsteady gravity water waves. Part 2. Dynamics and onset of breaking

    E-Print Network [OSTI]

    Barthelemy, X; Peirson, W L; Fedele, F; Allis, M; Dias, F

    2015-01-01

    We revisit the classical, but as yet unresolved problem of predicting the breaking onset of 2D and 3D irrotational gravity water waves. This study focuses on domains with flat bottom topography and conditions ranging from deep to intermediate depth (depth to wavelength ratio between 1 and 0.2). Using a fully-nonlinear boundary element model, our initial calculations investigated geometric, kinematic and energetic differences between maximally recurrent and marginally breaking waves in focusing wave groups. Maximallyrecurrent waves are clearly separated from marginally-breaking waves by their energy fluxes localized near the crest region. Specifically, tracking the local ratio of energy flux velocity to crest speed at the crest of the tallest wave in the evolving group provides a robust breaking onset threshold parameter. Warning of imminent breaking onset was found to depend on the strength of breaking, but was detectable only up to half a carrier wave period prior to a breaking event.

  5. Career Break Record of Contact Days Staff on a career break may, by agreement with their Head of School/Unit, undertake a number of days'

    E-Print Network [OSTI]

    Brierley, Andrew

    with their Head of School/Unit, undertake a number of days' paid work during their career break ("contact days"). The type of work undertaken is a matter of agreement between the member of staff and the Head of School/Unit: _________________________________________________________________ Staff ID/NI Number/ Date of Birth:_________________________________________ School/Unit

  6. A novel role for the transcriptional modulator NusA in DNA repair/damage tolerance pathways in Escherichia coli

    E-Print Network [OSTI]

    Cohen, Susan E., Ph. D. Massachusetts Institute of Technology

    2009-01-01

    All organisms must contend with the consequences of DNA damage, induced by a variety of both endogenous and exogenous sources. Mechanisms of DNA repair and DNA damage tolerance are crucial for cellular survival after DNA ...

  7. Using Differential Adhesion to Control Self-Assembly and Self-Repair of Collections of Modular Mobile Robots 

    E-Print Network [OSTI]

    Ottery, Peter

    This thesis presents a novel distributed control method which allows a collection of independently mobile robotic units, with two or three dimensional movement, to self-assemble into self-repairing hierarchical structures. ...

  8. Subterranean barriers, methods, and apparatuses for forming, inspecting, selectively heating, and repairing same

    DOE Patents [OSTI]

    Nickelson, Reva A. (Shelley, ID); Sloan, Paul A. (Rigby, ID); Richardson, John G. (Idaho Falls, ID); Walsh, Stephanie (Idaho Falls, ID); Kostelnik, Kevin M. (Idaho, ID)

    2009-04-07

    A subterranean barrier and method for forming same are disclosed, the barrier including a plurality of casing strings wherein at least one casing string of the plurality of casing strings may be affixed to at least another adjacent casing string of the plurality of casing strings through at least one weld, at least one adhesive joint, or both. A method and system for nondestructively inspecting a subterranean barrier is disclosed. For instance, a radiographic signal may be emitted from within a casing string toward an adjacent casing string and the radiographic signal may be detected from within the adjacent casing string. A method of repairing a barrier including removing at least a portion of a casing string and welding a repair element within the casing string is disclosed. A method of selectively heating at least one casing string forming at least a portion of a subterranean barrier is disclosed.

  9. Weld Repair of a Stamped Pressure Vessel in a Radiologically Controlled Zone

    SciTech Connect (OSTI)

    Cannell, Gary L.; Huth, Ralph J.; Hallum, Randall T.

    2013-08-26

    In September 2012 an ASME B&PVC Section VIII stamped pressure vessel located at the DOE Hanford Site Effluent Treatment Facility (ETF) developed a through-wall leak. The vessel, a steam/brine heat exchanger, operated in a radiologically controlled zone (by the CH2MHill PRC or CHPRC), had been in service for approximately 17 years. The heat exchanger is part of a single train evaporator process and its failure caused the entire system to be shut down, significantly impacting facility operations. This paper describes the activities associated with failure characterization, technical decision making/planning for repair by welding, logistical challenges associated with performing work in a radiologically controlled zone, performing the repair, and administrative considerations related to ASME code requirements.

  10. Chondrocyte outgrowth into a gelatin scaffold in a single impact load model of damage/repair - effect of BMP-2

    E-Print Network [OSTI]

    Henson, Frances M D; Vincent, Thea A

    2007-12-05

    damage repair response in mature equine articular cartilage explants following single impact load and subsequent culture [3]. This response is characterised Published: 5 December 2007 BMC Musculoskeletal Disorders 2007, 8:120 doi:10... ) degenerative joint disease, specifically osteoarthritis (OA) [2]. by the appearance of chondrocyte repair cells on damaged cartilage. This apparent mobilisation of chondrocytes has BMC Musculoskeletal Disorders 2007, 8:120 http://www.biomedcentral.com/1471...

  11. Precracked RC T-beams Repaired in Shear with Externally Bonded CFRP Sheets

    E-Print Network [OSTI]

    Dirar, Samir; Lees, Janet M.; Morley, Chris T.

    2012-03-01

    and repair of existing structures, advanced numerical analyses, glass fiber reinforced polymer pipelines and sustainable concrete. Chris Morley is a former Senior Lecturer in Concrete Structures at Cambridge University, UK. He has always been interested... , particularly in the case of bridges. Further factors that can have detrimental effects on capacity include corrosion of internal steel reinforcement, changes in use, poor initial design and more stringent assessment codes. One viable solution is to use fiber...

  12. Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency

    SciTech Connect (OSTI)

    Barnhoorn, Sander [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics.; Uittenboogaard, Lieneke M. [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics.; Jaarsma, Dick [Erasmus Univ. Medical Center, Rotterdam (The Netherlands). Dept. of Neuroscience.; Vermeij, Wilbert P. [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics.; Tresini, Maria [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics.; Weymaere, Michael [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics.; Menoni, Hervé [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics.; Brandt, Renata M. C. [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics.; de Waard, Monique C. [VU Univ. Medical Center, Amsterdam (The Netherlands). Dept. of Intensive Care.; Botter, Sander M. [Uniklinik Balgrist, Zurich (Switzerland); Sarker, Altaf H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division.; Jaspers, Nicolaas G. J. [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics; van der Horst, Gijsbertus T. J. [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics.; Cooper, Priscilla K. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division.; Hoeijmakers, Jan H. J. [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics.; van der Pluijm, Ingrid [Erasmus University Medical Center, Rotterdam (The Netherlands). Dept. of Genetics and Dept. of Vascular Surgery.; Niedernhofer, Laura J. [The Scripps Research Institute, San Diego, CA (United States)

    2014-10-09

    As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved in repair of helix-distorting DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-phenotype relationship in XPG patients. Defects in XPG can cause either the cancer-prone condition xeroderma pigmentosum (XP) alone, or XP combined with the severe neurodevelopmental disorder Cockayne Syndrome (CS), or the infantile lethal cerebro-oculo-facio-skeletal (COFS) syndrome, characterized by dramatic growth failure, progressive neurodevelopmental abnormalities and greatly reduced life expectancy. Here, we present a novel (conditional) Xpg-/- mouse model which—in a C57BL6/FVB F1 hybrid genetic background—displays many progeroid features, including cessation of growth, loss of subcutaneous fat, kyphosis, osteoporosis, retinal photoreceptor loss, liver aging, extensive neurodegeneration, and a short lifespan of 4–5 months. We show that deletion of XPG specifically in the liver reproduces the progeroid features in the liver, yet abolishes the effect on growth or lifespan. In addition, specific XPG deletion in neurons and glia of the forebrain creates a progressive neurodegenerative phenotype that shows many characteristics of human XPG deficiency. Our findings therefore exclude that both the liver as well as the neurological phenotype are a secondary consequence of derailment in other cell types, organs or tissues (e.g. vascular abnormalities) and support a cell-autonomous origin caused by the DNA repair defect itself. In addition they allow the dissection of the complex aging process in tissue- and cell-type-specific components. Moreover, our data highlight the critical importance of genetic background in mouse aging studies, establish the Xpg-/- mouse as a valid model for the severe form of human XPG patients and segmental accelerated aging, and strengthen the link between DNA damage and aging.

  13. Lethal Hemorrhage Caused by Aortoesophageal Fistula Secondary to Stent-Graft Repair of the Thoracic Aorta

    SciTech Connect (OSTI)

    Sager, Hendrik B., E-mail: hendrik.sager@uk-sh.de [Universitaet zu Luebeck, Medizinische Klinik II (Germany); Wellhoener, Peter [Universitaet zu Luebeck, Medizinische Klinik I (Germany); Wermelt, Johanna A. [Klinikum Neustadt, Klinik fuer Innere Medizin (Germany); Schunkert, Heribert; Kurowski, Volkhard [Universitaet zu Luebeck, Medizinische Klinik II (Germany)

    2011-02-15

    Aortoesophageal fistula (AEF) is a rare but life-threatening complication after endovascular or surgical aortic repair. Here we report a patient with AEF secondary to aortic stent-placement 2 years earlier who presented with hematemesis and died from hemorrhagic shock. By means of this case and the literature, we highlight potential bleeding sources in such a scenario because this is of crucial importance for the management strategy.

  14. Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Barnhoorn, Sander; Uittenboogaard, Lieneke M.; Jaarsma, Dick; Vermeij, Wilbert P.; Tresini, Maria; Weymaere, Michael; Menoni, Hervé; Brandt, Renata M. C.; de Waard, Monique C.; Botter, Sander M.; et al

    2014-10-09

    As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved in repair of helix-distorting DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-phenotype relationship in XPG patients. Defects in XPG can cause either the cancer-prone condition xeroderma pigmentosum (XP) alone, or XP combined with the severe neurodevelopmental disorder Cockayne Syndrome (CS), or the infantile lethal cerebro-oculo-facio-skeletal (COFS) syndrome, characterized by dramatic growth failure, progressive neurodevelopmental abnormalities and greatly reduced life expectancy. Here, we present a novel (conditional) Xpg-/- mouse model which—in a C57BL6/FVB F1 hybrid genetic background—displays manymore »progeroid features, including cessation of growth, loss of subcutaneous fat, kyphosis, osteoporosis, retinal photoreceptor loss, liver aging, extensive neurodegeneration, and a short lifespan of 4–5 months. We show that deletion of XPG specifically in the liver reproduces the progeroid features in the liver, yet abolishes the effect on growth or lifespan. In addition, specific XPG deletion in neurons and glia of the forebrain creates a progressive neurodegenerative phenotype that shows many characteristics of human XPG deficiency. Our findings therefore exclude that both the liver as well as the neurological phenotype are a secondary consequence of derailment in other cell types, organs or tissues (e.g. vascular abnormalities) and support a cell-autonomous origin caused by the DNA repair defect itself. In addition they allow the dissection of the complex aging process in tissue- and cell-type-specific components. Moreover, our data highlight the critical importance of genetic background in mouse aging studies, establish the Xpg-/- mouse as a valid model for the severe form of human XPG patients and segmental accelerated aging, and strengthen the link between DNA damage and aging.« less

  15. Quality Improvement Guidelines for Imaging Detection and Treatment of Endoleaks following Endovascular Aneurysm Repair (EVAR)

    SciTech Connect (OSTI)

    Rand, T.; Uberoi, R.; Cil, B.; Munneke, G.; Tsetis, D.

    2013-02-15

    Major concerns after aortic aneurysm repair are caused by the presence of endoleaks, which are defined as persistent perigraft flow within the aortic aneurysm sac. Diagnosis of endoleaks can be performed with various imaging modalities, and indications for treatment are based on further subclassifications. Early detection and correct classification of endoleaks are crucial for planning patient management. The vast majority of endoleaks can be treated successfully by interventional means. Guidelines for Imaging Detection and Treatment of endoleaks are described in this article.

  16. A deficiency in chromatin repair, genetic instability, and predisposition to cancer

    SciTech Connect (OSTI)

    Sanford, K.K.; Parshad, R.; Gantt, R.R.; Tarone, R.E. (National Cancer Institute, Bethesda, MD (USA))

    1989-01-01

    This review traces steps leading to malignant neoplastic transformation of rodent and human cells in culture and in vivo. Emphasis is placed on an abnormal response characterized by persistent chromatid damage following irradiation of cells in culture with X-rays or fluorescent light during G2 phase of the cell cycle. Evidence is presented that deficient or unbalanced DNA repair during G2 accounts for the abnormal response. This G2 repair deficiency can be inherited or acquired by normal tissue cells during the process of or following attainment of infinite lifespan. It appears as an early, possibly initiating step in neoplastic transformation. It characterizes all human tumor cells examined irrespective of histopathology or tissue of origin. It has a genetic basis. In an animal model, the BALB/c mouse, this phenotype is associated with genes on chromosomes 1 and 4. It characterizes skin fibroblasts and blood lymphocytes from individuals with genetic or familial conditions predisposing to cancer and can be used to identify clinically normal family members carrying a gene(s) for any one of the three cancer-prone genetic disorders studied to date. Furthermore, it can provide the basis of a test for carriers of genes predisposing to a high risk of cancer. We conclude that the G2 repair deficiency, whether inherited or acquired, is a prerequisite for cancer development and that it accounts for the genetic instability of the cancer cell. 167 refs.

  17. ASTRID sodium cooled fast reactor: Program for improving in service inspection and repair

    SciTech Connect (OSTI)

    Jadot, F.; De Dinechin, G.; Augem, J. M.; Sibilo, J.

    2011-07-01

    In the frame of the CEA, EDF, AREVA coordinated research program for the development of Generation IV sodium-cooled fast reactors (SFR), the ASTRID project was launched in 2010. For the future prototype, the improvement of in-service inspection and repair (ISI and R) capabilities was identified as a major issue. Following the pluri-annual SFR research program, the ISI and R main R and D axes remain: i) improvement of the primary system conceptual design, ii) development of measurement and inspection techniques (continuous monitoring instrumentation and periodic inspection tools), iii) accessibility and associated robotics, and iv) development and validation of repair processes. Associated ISI and R needs are being defined through an iterative method between designers and instrumentation specialists: adaptation of the Design to ISI and R requirements, fission chamber development, validation of the ultrasonic and chemical transducers, of ultrasonic non destructive simulation, of acoustic surveillance, of laser repair intervention processes, of connected robotic equipment. Moreover, CEA, as leader of the ASTRID Project, is willing to find new contributors, partners or suppliers, in order to get innovative, diversified, exhaustive and efficient solutions. (authors)

  18. Effects of $?$-cluster breaking on 3$?$ cluster structures in $^{12}$C

    E-Print Network [OSTI]

    Tadahiro Suhara; Yoshiko Kanada-En'yo

    2015-02-17

    To clarify the effects of $\\alpha$-cluster breaking on 3$\\alpha$ cluster structures in $^{12}$C, we investigate $^{12}$C using a hybrid model that combines the Brink-Bloch cluster model with the $p_{3/2}$ subshell closure wave function. We have found that $\\alpha$-cluster breaking caused by spin-orbit force significantly changes cluster structures of excited $0^{+}$ states through orthogonality to lower states. Spatially developed cluster components of the $0^{+}_{2}$ state are reduced. The $0^{+}_{3}$ state changes from a vibration mode in the bending motion of three $\\alpha$ clusters to a chain-like 3$\\alpha$ structure having an open triangle configuration. As a result of these structure changes of $0^{+}$ states, the band assignment for the $2^{+}_{2}$ state is changed by the $\\alpha$-cluster breaking effect. Namely, in model calculations without the $\\alpha$-cluster breaking effect, the $0^{+}_{2}$ state is assigned to be the band-head of the $2^{+}_{2}$ state. However, when we incorporate $\\alpha$-cluster breaking caused by the spin-orbit force, the $0^{+}_{3}$ state is regarded as the band-head of the $2^{+}_{2}$ state.

  19. SU(3) breaking effects in hyperon beta decay from lattice QCD

    E-Print Network [OSTI]

    Shoichi Sasaki; Takeshi Yamazaki

    2006-10-13

    We present results of an exploratory study of flavor SU(3) breaking effects in hyperon beta decays using domain wall fermions. From phenomenological point of view, the significance of this subject is twofold: (1) to extract the element $V_{us}$ of the Cabibbo-Kabayashi-Maskawa mixing matrix from the $\\Delta S=1$ decay process, and (2) to provide vital information to analysis of the strange quark fraction of the proton spin with the polarized deep inelastic scattering data. In this study, we explore the $\\Xi^0 \\to \\Sigma^+$ beta decay, which is highly sensitive to the SU(3) breaking since this decay corresponds to the direct analogue of neutron beta decay under an exchange between the down quark and the strange quark. We expose the SU(3) breaking effect on $g_A/g_V=g_1(0)/f_1(0)$ up to the first order in breaking. The second-class form factors $g_2$ and $f_3$, of which non-zero values are the direct signals of the SU(3) breaking effect, are also measured. Finally, we estimate $f_1(0)$ up to the second-order correction and then evaluate $|V_{us}|$ combined with the KTeV experiment.

  20. Optical observations of GRB 060124 afterglow: A case for an injection break

    E-Print Network [OSTI]

    Kuntal Misra; D. Bhattacharya; D. K. Sahu; Ram Sagar; G. C. Anupama; A. J. Castro-Tirado; S. S. Guziy; B. C. Bhatt

    2007-01-15

    We present broad band optical afterglow observations of a long duration GRB 060124 using the 1.04-m Sampurnanand Telescope at ARIES, Nainital and the 2.01-m HCT at IAO, Hanle, including the earliest ground based observations in R band for this GRB. We determine the decay slope of the light curve at different bands and examine the reality of a proposed jet break. We use data from our observations as well as others reported in the literature to construct light curves in different bands and make power law fits to them. The spectral slope of the afterglow emission in the optical band is estimated. Our first R-band observations were taken $\\sim 0.038$~d after burst. We find that all available optical data after this epoch are well fit by a single power law, with a temporal flux decay index $\\alpha\\sim 0.94$. We do not find any evidence of a jet break within our data, which extend till $\\sim 2$~d after the burst. The X-ray light curve, however, shows a distinct break around 0.6 day. We attribute this break to a steepening of the electron energy spectrum at high energies. We conclude that the above measurements are consistent with the picture of a standard fireball evolution with no jet break within $t\\sim 2$~days after the burst. This sets a lower limit of $3\\times 10^{50}$~erg to the total energy released in the explosion.

  1. The evolution of the break preclusion concept for nuclear power plants in Germany

    SciTech Connect (OSTI)

    Schulz, H.

    1997-04-01

    In the updating of the Guidelines for PWR`s of the {open_quotes}Reaktor-Sicherheitskommission{close_quotes} (RSK) in 1981 the requirements on the design have been changed with respect to the postulated leaks and breaks in the primary pressure boundary. The major change was a revision in the requirements for pipe whip protection. As a logical consequence of the {open_quotes}concept of basic safety{close_quotes} a guillotine type break or any other break type resulting in a large opening is not postulated any longer for the calculation of reaction and jet forces. As an upper limit for a leak an area of 0, 1 A (A = open cross section of the pipe) is postulated. This decision was based on a general assessment of the present PWR system design in Germany. Since then a number of piping systems have been requalified in the older nuclear power plants to comply with the break preclusion concept. Also a number of extensions of the concept have been developed to cover also leak-assumptions for branch pipes. Furthermore due considerations have been given to other aspects which could contribute to a leak development in the primary circuit, like vessel penetrations, manhole covers, flanges, etc. Now the break preclusion concept originally applied to the main piping has been developed into an integrated concept for the whole pressure boundary within the containment and will be applied also in the periodic safety review of present nuclear power plants.

  2. VOLUME 82, NUMBER 22 P H Y S I C A L R E V I E W L E T T E R S 31 MAY 1999 Bending and Base-Stacking Interactions in Double-Stranded DNA

    E-Print Network [OSTI]

    Zhang, Yang

    is proposed by taking into account the structural properties of realistic dsDNA. Bending energy of the sugar and un- winding instability of DNA. We suggest that the present model, after some revisions, will also

  3. Universal power law for the energy spectrum of breaking Riemann waves

    E-Print Network [OSTI]

    Dmitry Pelinovsky; Efim Pelinovsky; Elena Kartashova; Tatjana Talipova; Ayrat Giniyatullin

    2013-06-30

    The universal power law for the spectrum of one-dimensional breaking Riemann waves is justified for the simple wave equation. The spectrum of spatial amplitudes at the breaking time $t = t_b$ has an asymptotic decay of $k^{-4/3}$, with corresponding energy spectrum decaying as $k^{-8/3}$. This spectrum is formed by the singularity of the form $(x-x_b)^{1/3}$ in the wave shape at the breaking time. This result remains valid for arbitrary nonlinear wave speed. In addition, we demonstrate numerically that the universal power law is observed for long time in the range of small wave numbers if small dissipation or dispersion is accounted in the viscous Burgers or Korteweg-de Vries equations.

  4. More on cosmological constraints on spontaneous R-symmetry breaking models

    SciTech Connect (OSTI)

    Hamada, Yuta; Kobayashi, Tatsuo [Department of Physics, Kyoto University, Kyoto, 606-8502 (Japan); Kamada, Kohei [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, Hamburg, D-22607 (Germany); Ookouchi, Yutaka, E-mail: hamada@gauge.scphys.kyoto-u.ac.jp, E-mail: kohei.kamada@epfl.ch, E-mail: kobayash@gauge.scphys.kyoto-u.ac.jp, E-mail: yutaka.ookouchi@artsci.kyushu-u.ac.jp [Faculty of Arts and Science, Kyushu University, Fukuoka, 819–0395 (Japan)

    2014-01-01

    We study the spontaneous R-symmetry breaking model and investigate the cosmological constraints on this model due to the pseudo Nambu-Goldstone boson, R-axion. We consider the R-axion which has relatively heavy mass in order to complement our previous work. In this regime, model parameters, R-axions mass and R-symmetry breaking scale, are constrained by Big Bang Nucleosynthesis and overproduction of the gravitino produced from R-axion decay and thermal plasma. We find that the allowed parameter space is very small for high reheating temperature. For low reheating temperature, the U(1){sub R} breaking scale f{sub a} is constrained as f{sub a} < 10{sup 12?14} GeV regardless of the value of R-axion mass.

  5. LENS repair and modification of metal NW components:materials and applications guide.

    SciTech Connect (OSTI)

    Smugeresky, John E. (Sandia National Laboratories, Livermore, CA); Gill, David Dennis; Oberhaus, Jason (BWXT Y-12); Adams, Thad (Savannah River National Laboratory); VanCamp, Chad (Kansas City Plant)

    2006-11-01

    Laser Engineered Net Shaping{trademark} (LENS{reg_sign}) is a unique, layer additive, metal manufacturing technique that offers the ability to create fully dense metal features and components directly from a computer solid model. LENS offers opportunities to repair and modify components by adding features to existing geometry, refilling holes, repairing weld lips, and many other potential applications. The material deposited has good mechanical properties with strengths typically slightly higher that wrought material due to grain refinement from a quickly cooling weld pool. The result is a material with properties similar to cold worked material, but without the loss in ductility traditionally seen with such treatments. Furthermore, 304L LENS material exhibits good corrosion resistance and hydrogen compatibility. This report gives a background of the LENS process including materials analysis addressing the requirements of a number of different applications. Suggestions are given to aid both the product engineer and the process engineer in the successful utilization of LENS for their applications. The results of testing on interface strength, machinability, weldability, corrosion resistance, geometric effects, heat treatment, and repair strategy testing are all included. Finally, the qualification of the LENS process is briefly discussed to give the user confidence in selecting LENS as the process of choice for high rigor applications. The testing showed LENS components to have capability in repair/modification applications requiring complex castings (W80-3 D-Bottle bracket), thin wall parts requiring metal to be rebuilt onto the part (W87 Firing Set Housing and Y-12 Test Rings), the filling of counterbores for use in reservoir reclamation welding (SRNL hydrogen compatibility study) and the repair of surface defects on pressure vessels (SRNL gas bottle repair). The material is machinable, as testing has shown that LENS deposited material machines similar to that of welded metal. Tool wear is slightly higher in LENS material than in wrought material, but not so much that one would be concerned with increased tooling cost. The LENS process achieved process qualification for the AY1E0125 D-Bottle Bracket from the W80-3 LEP program, and in the effort, also underwent testing in weapons environments. These tests included structural dynamic response testing and drop testing. The LENS deposited parts were compared in these tests with conventionally machined parts and showed equivalency to such an extent that the parts were accepted for use in parallel path subsystem-level weapon environment testing. The evaluation of LENS has shown that the process can be a viable option when either complete metal parts are needed or existing metal parts require modification or repair. The LENS Qualification Technology Investment team successfully investigated new applications for the LENS process and showed that it has great applicability across the Nuclear Weapons Complex as well as in other high rigor applications.

  6. Building a market for small wind: The break-even turnkey cost of residential wind systems in the United States

    E-Print Network [OSTI]

    Edwards, Jennifer L.; Wiser, Ryan; Bolinger, Mark; Forsyth, Trudy

    2004-01-01

    Break-Even Turnkey Cost of Residential Wind Systems in theaggregate installed cost of a small wind system that couldand wind resource class, (2) significant cost reductions

  7. Building a market for small wind: The break-even turnkey cost of residential wind systems in the United States

    E-Print Network [OSTI]

    Edwards, Jennifer L.; Wiser, Ryan; Bolinger, Mark; Forsyth, Trudy

    2004-01-01

    L ABORATORY Building a Market for Small Wind: The Break-Evenemployer. BUILDING A MARKET FOR SMALL WIND: T HE B REAK -E

  8. The influence of pairing correlations on the isospin symmetry breaking corrections of superallowed Fermi beta decays

    SciTech Connect (OSTI)

    Cal Latin-Small-Letter-Dotless-I k, A. E.; Gerceklioglu, M.; Selam, C.

    2013-05-15

    Within the framework of quasi-particle random phase approximation, the isospin breaking correction of superallowed 0{sup +} {yields} 0{sup +} beta decay and unitarity of Cabibbo-Kobayashi-Maskawa mixing matrix have been investigated. The broken isotopic symmetry of nuclear part of Hamiltonian has been restored by Pyatov's method. The isospin symmetry breaking correction with pairing correlations has been compared with the previous results without pairing. The effect of pairing interactions has been examined for nine superallowed Fermi beta decays; their parent nuclei are {sup 26}Al, {sup 34}Cl, {sup 38}K, {sup 42}Sc, {sup 46}V, {sup 50}Mn, {sup 54}Co, {sup 62}Ga, {sup 74}Rb.

  9. Semiclassical treatment of symmetry breaking and bifurcations in a non-integrable potential

    E-Print Network [OSTI]

    M. V. Koliesnik; Ya. D. Krivenko-Emetov; A. G. Magner; K. Arita; M. Brack

    2014-11-10

    We have derived an analytical trace formula for the level density of the H\\'enon-Heiles potential using the improved stationary phase method, based on extensions of Gutzwiller's semiclassical path integral approach. This trace formula has the correct limit to the standard Gutzwiller trace formula for the isolated periodic orbits far from all (critical) symmetry-breaking points. It continuously joins all critical points at which an enhancement of the semiclassical amplitudes occurs. We found a good agreement between the semi- classical and the quantum oscillating level densities for the gross shell structures and for the energy shell corrections, solving the symmetry breaking problem at small energies.

  10. Symmetry breaking patterns and collective modes of spin-one color superconductors

    E-Print Network [OSTI]

    Tomas Brauner; Jin-yi Pang; Qun Wang

    2009-09-23

    Spin-one color superconductor is a viable candidate phase of dense matter in the interiors of compact stars. Its low-energy excitations will influence the transport properties of such matter and thus have impact on late-stage evolution of neutron stars. It also provides a good example of spontaneous symmetry breaking with rich breaking patterns. In this contribution, we reanalyze the phase diagram of a spin-one color superconductor and point out that a part of it is occupied by noninert states, which have been neglected in literature so far. We classify the collective Nambu--Goldstone modes, which are essential to the transport phenomena.

  11. Wave breaking phenomenon of lower-hybrid oscillations induced by a background inhomogeneous magnetic field

    SciTech Connect (OSTI)

    Maity, Chandan; Chakrabarti, Nikhil [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064 (India); Sengupta, Sudip [Institute for Plasma Research, Bhat, Gandhinagar 382428 (India)

    2012-10-15

    In a fluid description, we study space-time evolution of lower hybrid modes in a cold quasi-neutral homogeneous plasma in presence of a background inhomogeneous magnetic field. Within a linear analysis, a dispersion relation with inhomogeneous magnetic field shows 'phase mixing' of such oscillations. A manifestation of 'phase mixing' is shown in 'mode coupling.' By using Lagrangian variables, an exact solution is presented in parametric form of this nonlinear time dependent problem. It is demonstrated that initially excited lower hybrid modes always break via phase mixing phenomenon in presence of an inhomogeneous magnetic field. Breaking of such oscillations is revealed by the appearance of spikes in the plasma density profile.

  12. Spontaneous symmetry breaking in a two-doublet lattice Higgs model

    E-Print Network [OSTI]

    Randy Lewis; R. M. Woloshyn

    2010-09-01

    An SU(2) lattice gauge theory with two doublets of complex scalar fields is considered. All continuous symmetries are identified and, using the nonperturbative methods of lattice field theory, the phase diagram is mapped out by direct numerical simulation. Two-doublet models contain phase transitions that separate qualitatively distinct regions of the parameter space. In some regions global symmetries are spontaneously broken. For some special choices of the model parameters, the symmetry-breaking order parameter is calculated. The pattern of symmetry breaking is verified further through observation of Goldstone bosons.

  13. Multicritical Symmetry Breaking and Naturalness of Slow Nambu-Goldstone Bosons

    E-Print Network [OSTI]

    Tom Griffin; Kevin T. Grosvenor; Petr Horava; Ziqi Yan

    2013-09-02

    We investigate spontaneous global symmetry breaking in the absence of Lorentz invariance, and study technical Naturalness of Nambu-Goldstone (NG) modes whose dispersion relation exhibits a hierarchy of multicritical phenomena with Lifshitz scaling and dynamical exponents $z>1$. For example, we find NG modes with a technically natural quadratic dispersion relation which do not break time reversal symmetry and are associated with a single broken symmetry generator, not a pair. The mechanism is protected by an enhanced `polynomial shift' symmetry in the free-field limit.

  14. From Decay to Complete Breaking: Pulling the Strings in SU(2) Yang-Mills Theory

    SciTech Connect (OSTI)

    Pepe, M.; Wiese, U.-J.

    2009-05-15

    We study (2Q+1) strings connecting two static charges Q in (2+1)D SU(2) Yang-Mills theory. While the fundamental (2) string between two charges Q=(1/2) is unbreakable, the adjoint (3) string connecting two charges Q=1 can break. When a (4) string is stretched beyond a critical length, it decays into a (2) string by gluon pair creation. When a (5) string is stretched, it first decays into a (3) string, which eventually breaks completely. The energy of the screened charges at the ends of a string is well described by a phenomenological constituent gluon model.

  15. Mass Formulas Derived by Symmetry Breaking and Prediction of Masses on Heavy Flavor Hadrons

    E-Print Network [OSTI]

    Yi-Fang Chang

    2008-03-02

    The base is the Lagrangian of symmetry and its dynamical breaking or Higgs breaking. When the soliton-like solutions of the scalar field equations are substituted into the spinor field equations, in the approximation of non-relativity we derive the Morse-type potential, whose energy spectrum is the GMO mass formula and its modified accurate mass formula. According to the symmetry of s-c quarks, the heavy flavor hadrons which made of u,d and c quarks may be classified by SU(3) octet and decuplet. Then some simple mass formulas are obtained, from this we predict some masses of unknown hadrons.

  16. Proposal to negotiate the renewal of an existing blanket purchase contract for the repair, reconditioning or replacement of klystrons for CTF3 and associated accessories

    E-Print Network [OSTI]

    2012-01-01

    Proposal to negotiate the renewal of an existing blanket purchase contract for the repair, reconditioning or replacement of klystrons for CTF3 and associated accessories

  17. Role of global warming on the statistics of record-breaking temperatures S. Redner1,

    E-Print Network [OSTI]

    Redner, Sidney

    Role of global warming on the statistics of record-breaking temperatures S. Redner1, * and Mark R in Philadelphia, as a function of the number of years of observation. We then consider the case of global warming question arises: is global warming the cause of such heat waves or are they merely statistical fluctuations

  18. Dam breaking by wave-induced erosional incision N. J. Balmforth,1

    E-Print Network [OSTI]

    Balmforth, Neil

    displacement wave can lead to catastrophic erosional incision of a moraine damming a glacial lake incision can also breach moraines damming glacial lakes. In a few of these examples, the incipient channel of extreme climate conditions or intense glacier melting). However, several other dam-break events appear

  19. Role of Symmetry Breaking on the Optical Transitions in Lead-Salt Quantum Dots

    E-Print Network [OSTI]

    Van Stryland, Eric

    Role of Symmetry Breaking on the Optical Transitions in Lead-Salt Quantum Dots Gero Nootz to explain optical transitions in lead-salt QDs. Thus, while the band anisotropy of the bulk semiconductor functions. These studies clarify the controversy of the origin of spectral features in lead-salt QDs

  20. Analytical relation between quark confinement and chiral symmetry breaking in odd-number lattice QCD

    E-Print Network [OSTI]

    Hideo Suganuma; Takahiro M. Doi; Takumu Iritani

    2013-12-21

    To clarify the relation between confinement and chiral symmetry breaking in QCD, we consider a temporally odd-number lattice, with the temporal lattice size $N_t$ being odd. We here use an ordinary square lattice with the normal (nontwisted) periodic boundary condition for link-variables in the temporal direction. By considering ${\\rm Tr} (\\hat{U}_4\\hat{\

  1. A CP Based Branching Tool for Breaking Symmetries in Crude-Oil Operations Scheduling

    E-Print Network [OSTI]

    Grossmann, Ignacio E.

    A CP Based Branching Tool for Breaking Symmetries in Crude-Oil Operations Scheduling Sylvain Mouret Goals Optimize the schedule of operations for the crude-oil unloading and blending problem using in the MINLP model Use CP inference techniques to improve performance 1 / 14 #12;Crude-oil operations

  2. A Symmetry-Breaking Tool for the Optimization of Crude-Oil Operations Scheduling

    E-Print Network [OSTI]

    Grossmann, Ignacio E.

    A Symmetry-Breaking Tool for the Optimization of Crude-Oil Operations Scheduling Sylvain Mouret the schedule of operations for the crude-oil unloading and blending problem using a continuous and Mann (2003) #12;Crude-oil operations scheduling problem Scheduling horizon [0, H] 4 types of resources

  3. UNIVERSITY OF CALIFORNIA, SAN DIEGO MOLD: A System for Breaking Down Large Visualization

    E-Print Network [OSTI]

    Baden, Scott B.

    UNIVERSITY OF CALIFORNIA, SAN DIEGO MOLD: A System for Breaking Down Large Visualization and Post thanks go out to Scott Baden and Peter Diamessis for their countless hours of help with MOLD. Thanks (NPACI) under NSF contract ACI9619020, by the UC MICRO program award number 99-007, and by Sun

  4. Low-energy signals of strongly-coupled electroweak symmetry-breaking scenarios

    E-Print Network [OSTI]

    Antonio Pich; Ignasi Rosell; Joaquin Santos; Juan Jose Sanz-Cillero

    2015-10-12

    Generic strongly-coupled scenarios of electroweak symmetry breaking usually contain towers of heavy states. We analyze the imprints that the lightest bosonic excitations leave on the couplings of the low-energy electroweak effective Lagrangian. The different quantum numbers of the heavy states imply different patterns of low-energy couplings, with characteristic correlations which could be identified in future data samples.

  5. 2012 EAGE www.firstbreak.org 97 special topicfirst break volume 30, July 2012

    E-Print Network [OSTI]

    Ali, Mohammed

    . Such estimation could be useful for monitoring network design, seismic risk management, and also for adjustment© 2012 EAGE www.firstbreak.org 97 special topicfirst break volume 30, July 2012 Passive Seismic 1@seismik.cz Expected level of seismic activity caused by volumetric changes Miroslav Hallo,1 Leo Eisner2* and Mohammed

  6. Trends and breaks in per-capita carbon dioxide emissions, 1870-2028

    E-Print Network [OSTI]

    Lanne, Markku

    2003-01-01

    We consider per-capita carbon dioxide emission trends in 16 early developed countries over the period 1870-2028. Using a multiple-break time series method we find more evidence for very early downturns in per-capita trends ...

  7. NANODIAMOND DUST AND THE FAR-ULTRAVIOLET QUASAR BREAK Luc Binette,1

    E-Print Network [OSTI]

    Morisset, Christophe

    NANODIAMOND DUST AND THE FAR-ULTRAVIOLET QUASAR BREAK Luc Binette,1 Gladis Magris C.,2 Yair curve consisting of nanodiamonds, composed of terrestrial cubic diamonds or with surface impurities intrinsic dust model requires a mixture of both cubic diamonds and Allende nanodiamonds and provides

  8. The Direct Breaking of Internal Waves at Steep1 Topography2

    E-Print Network [OSTI]

    Klymak, Jody M.

    1 The Direct Breaking of Internal Waves at Steep1 Topography2 Jody M. Klymak, Sonya Legg, Matthew H steep "supercritical" topography (i.e. topography that is steeper than internal wave energy13, but in those cases their17 wavelengths are of similar scale to the topography, whereas here they are quite

  9. Variational Inference for Stick-Breaking Beta Process Priors John Paisley1

    E-Print Network [OSTI]

    Carin, Lawrence

    Variational Inference for Stick-Breaking Beta Process Priors John Paisley1 jpaisley-parameter IBP, and does not extend to the beta process presented in (Hjort, 1990). Recently, Paisley et al., 2007); we discuss this difference in Sec- tion 4. Paisley et al. (2010) presented an inference

  10. Stick-Breaking Beta Processes and the Poisson Process John Paisley1

    E-Print Network [OSTI]

    Jordan, Michael I.

    Stick-Breaking Beta Processes and the Poisson Process John Paisley1 David M. Blei3 Michael I to Paisley et al. (2010) can be obtained from the characterization of the beta process as a Poisson process beta pro- cess was derived by Paisley et al. (2010). The derivation re- lied on a limiting process

  11. 10/12/2004 Comp 120 Fall 2004 1 No class Thursday 14 October (Fall Break!)

    E-Print Network [OSTI]

    Bishop, Gary

    ·1 10/12/2004 Comp 120 Fall 2004 1 October 12 · No class Thursday 14 October (Fall Break!) · GB gone 17 through 20 October · Review for 2nd Exam on Tuesday 19 October · Ask Questions! 10/12/2004 Comp 120 Fall 2004 2 Chapter 1 · Computer Abstractions · Input/Output/Memory/Datapath/Control · Instruction

  12. Conformal symmetry breaking and degeneracy of high-lying unflavored mesons

    E-Print Network [OSTI]

    Kirchbach, Mariana; Compean, Cliffor; Raya, Alfredo

    2012-01-01

    We show that though conformal symmetry can be broken by the dilaton, such can happen without breaking the conformal degeneracy patterns in the spectra. We departure from S^1XS^3 slicing of AdS_5 noticing that the inverse radius, R, of S^3 relates to the temperature of the deconfinement phase transition and has to satisfy, \\hbar c/R >> \\Lambda_{QCD}. We then focus on the eigenvalue problem of the S^3 conformal Laplacian, given by 1/R^2 (K^2+1), with K^2 standing for the Casimir invariant of the so(4) algebra. Such a spectrum is characterized by a (K+1)^2 fold degeneracy of its levels, with K\\in [0,\\infty). We then break the conformal S^3 metric as, d\\tilde{s}^2=e^{-b\\chi} ((1+b^2) d\\chi^2 +\\sin^2\\chi (d\\theta ^2 +\\sin^2\\theta d\\varphi ^2)), and attribute the symmetry breaking scale, b\\hbar^2c^2/R^2, to the dilaton. We show that such a metric deformation is equivalent to a breaking of the conformal curvature of S^3 by a term proportional to b\\cot \\chi, and that the perturbed conformal Laplacian is equivalent to...

  13. A BreakEven Formulation for Evaluating Branch Predictor Energy Efficiency #

    E-Print Network [OSTI]

    Huang, Wei

    A Break­Even Formulation for Evaluating Branch Predictor Energy Efficiency # Michele Co, Dee A demonstrated that a better branch pre­ dictor can increase the energy­efficiency of the system, even if the new a simple, effective metric for eval­ uating the tradeoff between processor energy­efficiency and branch

  14. Short-pulse equation: well-posedness and wave breaking Dmitry Pelinovsky

    E-Print Network [OSTI]

    Pelinovsky, Dmitry

    Short-pulse equation: well-posedness and wave breaking Dmitry Pelinovsky Department of Mathematics-629 (2010) #12;Properties of the short-pulse equation The short-pulse equation is a model for propagation of ultra-short pulses with few cycles on the pulse scale [Schäfer, Wayne 2004]: uxt = u + 1 6 ` u3 ´ xx

  15. Short-pulse equation: well-posedness and wave breaking Dmitry Pelinovsky

    E-Print Network [OSTI]

    Pelinovsky, Dmitry

    Short-pulse equation: well-posedness and wave breaking Dmitry Pelinovsky Department of Mathematics, Communications in PDE 35, 613-629 (2010) #12;Properties of the short-pulse equation The short-pulse equation is a model for propagation of ultra-short pulses [Schäfer, Wayne 2004]: uxt = u + 1 6 ` u3´ xx , where all

  16. Generation, propagation, and breaking of an internal wave beam Heather A. Clark and Bruce R. Sutherlanda

    E-Print Network [OSTI]

    Sutherland, Bruce

    Generation, propagation, and breaking of an internal wave beam Heather A. Clark and Bruce R of internal gravity waves generated by the large-amplitude vertical oscillations of a circular cylinder predictions and experimental investigations of waves generated by small-amplitude cylinder oscillations

  17. Coherent States and Spontaneous Symmetry Breaking in Light Front Scalar Field Theory

    SciTech Connect (OSTI)

    Vary, J.P.; Chakrabarti, D.; Harindranath, A.; Lloyd, R.; Martinovic, L.; Spence, J.R.; /Iowa State U.

    2005-12-14

    Recently developed nuclear many-body techniques provide novel results when applied to constituent quark models and to light-front scalar field theory. We show how spontaneous symmetry breaking arises and is consistent with a coherent state ansatz in a variational treatment. The kink and the kink-antikink topological features are identified and the onset of symmetry restoration is demonstrated.

  18. Experimental and Theoretical Investigations of Energy Transfer and Hydrogen-Bond Breaking in the Water Dimer

    E-Print Network [OSTI]

    Reisler, Hanna

    Experimental and Theoretical Investigations of Energy Transfer and Hydrogen-Bond Breaking, Georgia 30322, United States *W Web-Enhanced Feature *S Supporting Information ABSTRACT: The hydrogen determination of the dissociation energy (D0) of (D2O)2. The value obtained, 1244 ± 10 cm-1 (14.88 ± 0.12 k

  19. Studying the Breaking Mechanism of Polymer-Based In-Situ Gelled Acids using Solid Breaker 

    E-Print Network [OSTI]

    Tian, Zhida

    2012-10-19

    of this study is to examine the working mechanisms of the solid breaker and the factors that affect the breaking time. The flowback of the spent acid and the core damage induced by it will also be assessed in detail. Viscosity and rheological experimental...

  20. IEEE Signal Processing Magazine, Special Issue: Big Data 1 Breaking the Curse of Dimensionality using

    E-Print Network [OSTI]

    IEEE Signal Processing Magazine, Special Issue: Big Data 1 Breaking the Curse of Dimensionality will discuss two promising tools to alleviate this curse when handling big data. First, instead of using full, Special Issue: Big Data 2 paper we show how to use this expertise to manage otherwise unmanageable big

  1. Information-Entropic for Travelling Solitons in Lorentz and CPT Breaking Systems

    E-Print Network [OSTI]

    R. A. C. Correa; Roldao da Rocha; A. de Souza Dutra

    2015-02-08

    In this work we group three research topics apparently disconnected, namely solitons, Lorentz symmetry breaking and entropy. Following a recent work [Phys. Lett. B 713 (2012) 304], we show that it is possible to construct in the context of travelling wave solutions a configurational entropy measure in functional space, from the field configurations. Thus, we investigate the existence and properties of travelling solitons in Lorentz and CPT breaking scenarios for a class of models with two interacting scalar fields. Here, we obtain a complete set of exact solutions for the model studied which display both double and single-kink configurations. In fact, such models are very important in applications that include Bloch branes, Skyrmions, Yang-Mills, Q-balls, oscillons and various superstring-motivated theories. We find that the so-called Configurational Entropy (CE) for travelling solitons, which we name as travelling Configurational Entropy (TCE), shows that the best value of parameter responsible to break the Lorentz symmetry is one where the energy density is distributed equally around the origin. In this way, the information-theoretical measure of travelling solitons in Lorentz symmetry violation scenarios opens a new window to probe situations where the parameters responsible for breaking the symmetries are random. In this case, the TCE selects the best value.

  2. Editing Functional Programs Without Breaking Them Edward Amsden Ryan Newton Jeremy Siek

    E-Print Network [OSTI]

    Tobin-Hochstadt, Sam

    Editing Functional Programs Without Breaking Them Edward Amsden Ryan Newton Jeremy Siek Indiana how general-purpose program- ming might proceed given this set of editing actions. Categories types to guide the editing opera- tions on terms. Rather than entering programs as text, programmers

  3. EFFECT OF MOISTURE ON BENDING AND BREAKING RESISTANCE (IF COMMERCIAL ORIENTED STRANDBOARDS1

    E-Print Network [OSTI]

    ) ABSTRACT This is ZI short addendum to an earlier paper (Wu and Suchsland 1997) on bending resistance (E.1EFFECT OF MOISTURE ON BENDING AND BREAKING RESISTANCE (IF COMMERCIAL ORIENTED STRANDBOARDS1 Qinglin the quality and performance of OSB. In an F ) ~ ~ ~ ~ ~ ~ ~ ~Wu and Suchsland However, the paper did

  4. Breaking News Export Control Certification on I-129 Required 21 Feb. 2011

    E-Print Network [OSTI]

    Scharer, John E.

    Breaking News Export Control Certification on I-129 Required 21 Feb. 2011 Effective 21 February-129 regarding compliance with the deemed export licensing requirements of the export control as the UW-Madison Export Control Officer, Tom Demke, to provide clear instructions and a form to ensure our

  5. Infrared Luminous Lyman Break Galaxies: A Population that Bridges LBGs and SCUBA Galaxies

    E-Print Network [OSTI]

    Huang, J.-S.; Rigopoulou, D.; Willner, S. P.; Papovich, C.; Shu, C.; Ashby, M. L. N.; Barmby, P.; Bundy, K.; Conselice, C. J.; Egami, E.; Pé rez-Gonzá lez, P. G.; Rosenberg, J. L.; Smith, H. A.; Wilson, Graham Wallace; Fazio, G. G.

    2005-11-20

    A deep mid- and far-infrared survey in the extended Groth strip (EGS) area gives 3.6 to 8 ?m flux densities or upper limits for 253 Lyman break galaxies (LBGs). The LBGs are a diverse population but with properties correlated ...

  6. AEGIS: Infrared Spectroscopy of an Infrared-luminous Lyman Break Galaxy at z = 3.01

    E-Print Network [OSTI]

    Huang, J.-S.; Rigopoulou, D.; Papovich, C.; Ashby, M. L. N.; Willner, S. P.; Ivison, R.; Laird, E. S.; Webb, T.; Wilson, Graham Wallace; Barmby, P.; Chapman, S.; Conselice, C. J.; McLeod, B.; Shu, C. G.; Smith, H. A.; Le Floc'h, E.; Egami, E.; Willmer, C. A. N.; Fazio, G. G.

    2007-05-01

    We report the detection of rest-frame 6.2 and 7.7 ?m emission features arising from polycyclic aromatic hydrocarbons (PAHs) in the Spitzer IRS spectrum of an infrared-luminous Lyman break galaxy at z = 3.01. This is currently ...

  7. Breaking NLM-MAC Generator Mohammad Ali Orumiehchiha1, Josef Pieprzyk1, and Ron Steinfeld2

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    of the cipher. Due to a high correlation between the input variables and the output sequences of the combiningBreaking NLM-MAC Generator Mohammad Ali Orumiehchiha1, Josef Pieprzyk1, and Ron Steinfeld2 1 Center generator, designed by HoonJae Lee, SangMin Sung, HyeongRag Kim, is the strengthened version of the LM

  8. Numerical Simulation of Breaking Waves Using Level-Set Navier-Stokes Method 

    E-Print Network [OSTI]

    Dong, Qian

    2010-07-14

    ) equations were employed for the prediction of nonlinear wave-interaction and wave-breaking phenomena over sloping beaches. In the level-set finite-analytic Navier-Stokes (FANS) method, the free surface is represented by the zero level-set function...

  9. Experimental Study on Kinematics and Dynamics of Breaking Waves in Deep Water 

    E-Print Network [OSTI]

    Lim, Ho Joon

    2011-10-21

    improved accuracy. This modified technique was used for measuring of a NaCl concentration in deionized water to validate a new normalization technique. In the second part of this thesis, a plunging breaking wave in deep water has been studied. Using...

  10. Remote sensing of breaking wave phase speeds with application to non-linear depth inversions

    E-Print Network [OSTI]

    Haller, Merrick

    Remote sensing of breaking wave phase speeds with application to non-linear depth inversions high-resolution remote sensing video and surface elevation records from fixed, in-situ wave gages. Wave phase speeds are extracted from the remote sensing data using a feature tracking technique, and local

  11. SUCTION BREAK TO CONTROL SLOPE-INDUCED MOISTURE VARIATION IN LAYERED COVERS

    E-Print Network [OSTI]

    Aubertin, Michel

    was not affected even after 78 days without water infiltration. Also, in situ tests with large precipitation lead capacity. This study showed that a suction break could be used to improve the performance of inclined CCBE jours sans infiltrations d'eau. Les essais d'infiltration avec des taux de précipitations élevés ont

  12. All Your Face Are Belong to Us: Breaking Facebook's Social Authentication

    E-Print Network [OSTI]

    Keromytis, Angelos D.

    All Your Face Are Belong to Us: Breaking Facebook's Social Authentication Iasonas Polakis FORTH adversaries from compromising accounts using stolen credentials. Facebook has recently released a two can obtain the information needed to solve the chal- lenges presented by Facebook. We implement

  13. Facebook, Twitter and Google Plus for Breaking News: Is there a winner? Miles Osborne

    E-Print Network [OSTI]

    Osborne, Miles

    Facebook, Twitter and Google Plus for Breaking News: Is there a winner? Miles Osborne School Media have be- gun to carry news. Here we examine how Facebook, Google Plus and Twitter report Facebook or Google Plus. Face- book and Google Plus largely repost newswire stories and their main research

  14. Low-energy signals of strongly-coupled electroweak symmetry-breaking scenarios

    E-Print Network [OSTI]

    Pich, Antonio; Santos, Joaquin; Sanz-Cillero, Juan Jose

    2015-01-01

    Generic strongly-coupled scenarios of electroweak symmetry breaking usually contain towers of heavy states. We analyze the imprints that the lightest bosonic excitations leave on the couplings of the low-energy electroweak effective Lagrangian. The different quantum numbers of the heavy states imply different patterns of low-energy couplings, with characteristic correlations which could be identified in future data samples.

  15. Numerical simulation of breaking waves by a multi-scale turbulence model

    E-Print Network [OSTI]

    Zhao, Qun

    and diffusion are of the same order at the trough level. Above the trough level, turbulent convection dominates-dimensional MAC type finite difference method. The third-order upwind scheme proposed by Kawamura and KawaharaNumerical simulation of breaking waves by a multi-scale turbulence model Qun Zhaoa,*, Steve

  16. WHERE DOES FLUID-LIKE TURBULENCE BREAK DOWN IN THE SOLAR WIND?

    SciTech Connect (OSTI)

    Perri, S.; Carbone, V.; Veltri, P.

    2010-12-10

    Power spectra of the magnetic field in solar wind display a Kolmogorov law f {sup -5/3} at intermediate range of frequencies f, say within the inertial range. Two spectral breaks are also observed: one separating the inertial range from an f {sup -1} spectrum at lower frequencies, and another one between the inertial range and an f {sup -7/3} spectrum at higher frequencies. The breaking of fluid-like turbulence at high frequencies has been attributed to either the occurrence of kinetic Alfven wave fluctuations above the ion-cyclotron frequency or to whistler turbulence above the frequency corresponding to the proton gyroradius. Using solar wind data, we show that the observed high-frequency spectral break seems to be independent of the distance from the Sun, and then of both the ion-cyclotron frequency and the proton gyroradius. We suppose that the observed high-frequency break could be either caused by a combination of different physical processes or associated with a remnant signature of coronal turbulence.

  17. SPH Study of the Evolution of Water-Water Interfaces in Dam Break Flows

    E-Print Network [OSTI]

    Jian, Wei; Liang, Dongfang; Shao, Songdong; Chen, Ridong; Liu, Xingnian

    2015-04-08

    but also tides and tsunamis. 465 466 467 20 5.1 Model setup and computational parameters 468 469 The numerical setup of this hypothetical dam-break problem consists of a 2000 m long 470 horizontal water tank. Water is initially...

  18. 2014-2015 Trip Information Fall Break: October 22-25, 2014

    E-Print Network [OSTI]

    Almor, Amit

    Click Here Poverty & Elderly; Christmas in Action; Spartanburg, SC Trip Leader: Tina Mauer Christmas disadvantaged homeowners. For more information Click Here Poverty & Homelessness; Habitat for Humanity; John Click Here Spring Break: March 7-14, 2015 Hunger & Poverty; C.R.O.S. Ministries; West Palm Beach, FL

  19. Propagation of continental break-up in the southwestern South China Sea

    E-Print Network [OSTI]

    Nicolas, Chamot-Rooke

    Lhomond, 75231 Paris Cedex 05, France 2present address: Gdosciences Azur, Pierre & Marie Curie University on the southwestern tip of the South China Sea oceanic basin, where propagation of continental break-up occurred of the South China Sea basin, one of the best examples of an ocea- nic basin with a propagating ridge geometry

  20. FRONTIERS ARTICLE Imaging bond breaking and vibrational energy transfer in small water

    E-Print Network [OSTI]

    Reisler, Hanna

    FRONTIERS ARTICLE Imaging bond breaking and vibrational energy transfer in small water containing it is possible to generate accurate potential energy surfaces (PESs) for small clusters, such as those of water (REMPI) are used to determine accurate bond dissociation energies (D0) of (H2O)2, (H2O)3, HCl­H2O and NH3

  1. Development and validation of nondestructive inspection techniques for composite doubler repairs on commercial aircraft

    SciTech Connect (OSTI)

    Roach, D.; Walkington, P.

    1998-05-01

    Composite doublers, or repair patches, provide an innovative repair technique which can enhance the way aircraft are maintained. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is possible to bond a single boron-epoxy composite doubler to the damaged structure. In order for the use of composite doublers to achieve widespread use in the civil aviation industry, it is imperative that methods be developed which can quickly and reliably assess the integrity of the doubler. In this study, a specific composite application was chosen on an L-1011 aircraft in order to focus the tasks on application and operation issues. Primary among inspection requirements for these doublers is the identification of disbonds, between the composite laminate and aluminum parent material, and delaminations in the composite laminate. Surveillance of cracks or corrosion in the parent aluminum material beneath the doubler is also a concern. No single nondestructive inspection (NDI) method can inspect for every flaw type, therefore it is important to be aware of available NDI techniques and to properly address their capabilities and limitations. A series of NDI tests were conducted on laboratory test structures and on full-scale aircraft fuselage sections. Specific challenges, unique to bonded composite doubler applications, were highlighted. An array of conventional and advanced NDI techniques were evaluated. Flaw detection sensitivity studies were conducted on applicable eddy current, ultrasonic, X-ray and thermography based devices. The application of these NDI techniques to composite doublers and the results from test specimens, which were loaded to provide a changing flaw profile, are presented in this report. It was found that a team of these techniques can identify flaws in composite doubler installations well before they reach critical size.

  2. Conformal symmetry breaking and degeneracy of high-lying unflavored mesons

    E-Print Network [OSTI]

    Mariana Kirchbach; Adrian Pallares-Rivera; Cliffor Compean; Alfredo Raya

    2012-07-13

    We show that though conformal symmetry can be broken by the dilaton, such can happen without breaking the conformal degeneracy patterns in the spectra. We departure from R^1XS^3 slicing of AdS_5 noticing that the inverse radius, R, of S^3 relates to the temperature of the deconfinement phase transition and has to satisfy, \\hbar c/R >> \\Lambda_{QCD}. We then focus on the eigenvalue problem of the S^3 conformal Laplacian, given by 1/R^2 (K^2+1), with K^2 standing for the Casimir invariant of the so(4) algebra. Such a spectrum is characterized by a (K+1)^2 fold degeneracy of its levels, with K\\in [0,\\infty). We then break the conformal S^3 metric as, d\\tilde{s}^2=e^{-b\\chi} ((1+b^2/4) d\\chi^2 +\\sin^2\\chi (d\\theta ^2 +\\sin^2\\theta d\\varphi ^2)), and attribute the symmetry breaking scale, b\\hbar^2c^2/R^2, to the dilaton. We show that such a metric deformation is equivalent to a breaking of the conformal curvature of S^3 by a term proportional to b\\cot \\chi, and that the perturbed conformal Laplacian is equivalent to (\\tilde{K}^2 +c_K), with c_K a representation constant, and \\tilde{K}^2 being again an so(4) Casimir invariant, but this time in a representation unitarily inequivalent to the 4D rotational. In effect, the spectra before and after the symmetry breaking are determined each by eigenvalues of a Casimir invariant of an so(4) algebra, a reason for which the degeneracies remain unaltered though the conformal group symmetry breaks at the level of the representation of its algebra. We fit the S^3 radius and the \\hbar^2c^2b/R^2 scale to the high-lying excitations in the spectra of the unflavored mesons, and observe the correct tendency of the \\hbar c /R=373 MeV value to notably exceed \\Lambda_{QCD}. The size of the symmetry breaking scale is calculated as \\hbar c \\sqrt{b}/R=673.7 MeV.

  3. JAG Tearing Technique with Radiofrequency Guide Wire for Aortic Fenestration in Thoracic Endovascular Aneurysm Repair

    SciTech Connect (OSTI)

    Ricci, Carmelo [Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Radiologia Interventistica (Italy); Ceccherini, Claudio, E-mail: claudiocec@hotmail.it; Leonini, Sara [Radiologia Universitaria, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte (Italy); Cini, Marco; Vigni, Francesco [Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Radiologia Interventistica (Italy); Neri, Eugenio; Tucci, Enrico; Benvenuti, Antonio; Tommasino, Giulio; Sassi, Carlo [Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Chirurgia dell'Aorta Toracica (Italy)

    2012-02-15

    An innovative approach, the JAG tearing technique, was performed during thoracic endovascular aneurysm repair in a patient with previous surgical replacement of the ascending aorta with a residual uncomplicated type B aortic dissection who developed an aneurysm of the descending thoracic aorta with its lumen divided in two parts by an intimal flap. The proximal landing zone was suitable to place a thoracic stent graft. The distal landing zone was created by cutting the intimal flap in the distal third of the descending thoracic aorta with a radiofrequency guide wire and intravascular ultrasound catheter.

  4. Exposure Evaluation for Benzene, Lead and Noise in Vehicle and Equipment Repair Shops

    SciTech Connect (OSTI)

    Sweeney, Lynn C.

    2013-04-10

    An exposure assessment was performed at the equipment and vehicle maintenance repair shops operating at the U. S. Department of Energy Hanford site, in Richland, Washington. The maintenance shops repair and maintain vehicles and equipment used in support of the Hanford cleanup mission. There are three general mechanic shops and one auto body repair shop. The mechanics work on heavy equipment used in construction, cranes, commercial motor vehicles, passenger-type vehicles in addition to air compressors, generators, and farm equipment. Services include part fabrication, installation of equipment, repair and maintenance work in the engine compartment, and tire and brake services. Work performed at the auto body shop includes painting and surface preparation which involves applying body filler and sanding. 8-hour time-weighted-average samples were collected for benzene and noise exposure and task-based samples were collected for lead dust work activities involving painted metal surfaces. Benzene samples were obtained using 3M™ 3520 sampling badges and were analyzed for additional volatile organic compounds. These compounds were selected based on material safety data sheet information for the aerosol products used by the mechanics for each day of sampling. The compounds included acetone, ethyl ether, toluene, xylene, VM&P naphtha, methyl ethyl ketone, and trichloroethylene. Laboratory data for benzene, VM&P naphtha, methyl ethyl ketone and trichloroethylene were all below the reporting detection limit. Airborne concentrations for acetone, ethyl ether, toluene and xylene were all less than 10% of their occupational exposure limit. The task-based samples obtained for lead dusts were submitted for a metal scan analysis to identify other metals that might be present. Laboratory results for lead dusts were all below the reporting detection limit and airborne concentration for the other metals observed in the samples were less than 10% of the occupational exposure limit. Noise dosimetry sampling was performed on a random basis and was representative of the different work activities within the four shops. Twenty three percent of the noise samples exceeded the occupational exposure limit of 85 decibels for an 8-hour time-weightedaverage. Work activities where noise levels were higher included use of impact wrenches and grinding wheels.

  5. Why do continents break-up parallel to ancient orogenic belts? A. Vauchez*, G. Barruol and A. Tommasi?

    E-Print Network [OSTI]

    Barruol, Guilhem

    Why do continents break-up parallel to ancient orogenic belts? A. Vauchez*, G. Barruol and A belts Ocean-opening through rifting and continent break-up is frequently related to the occurrence Atlantic oceans provide spectacularexamples of parallelism be- tween rifts and older orogenic belts

  6. Hydrogen Bond Networks: Structure and Evolution after Hydrogen Bond Breaking John B. Asbury, Tobias Steinel, and M. D. Fayer*

    E-Print Network [OSTI]

    Fayer, Michael D.

    Hydrogen Bond Networks: Structure and Evolution after Hydrogen Bond Breaking John B. Asbury, TobiasVed: September 1, 2003; In Final Form: December 18, 2003 The nature of hydrogen bonding networks following hydrogen bond breaking is investigated using vibrational echo correlation spectroscopy of the hydroxyl

  7. Dofasco`s No. 4 blast furnace hearth breakout, repair and rescue

    SciTech Connect (OSTI)

    Donaldson, R.J.; Fischer, A.J.; Sharp, R.M.; Stothart, D.W. [Dofasco Inc., Hamilton, Ontario (Canada)

    1995-12-01

    On May 5, 1994, after producing 9.5 million metric tons of iron, Dofasco`s No. 4 Blast Furnace experienced a hearth breakout 250 millimeters below the west taphole. The hot metal spill caused a fire resulting in severe damage and 33 days of lost production. During a 26-day period, electrical wiring, water drainage systems and both tapholes were repaired. Recovery from an unprepared furnace stop of this length, with the deadman depleted is difficult. To aid with the rescue Hoogovens-designed oxygen/fuel lances were commissioned. The furnace recovery began with a lance in each taphole and all tuyeres plugged. Six days after startup the furnace was casting into torpedo cars, and after nine days operation had returned to normal. This incident prompted Dofasco to expand the hearth monitoring system to detect and prevent similar occurrences. During the repair, 203 new thermocouples were installed in the hearth, concentrating on the tapholes and elephant foot areas. These thermocouples were installed at various depths and locations to allow heat flux calculations. This hearth monitoring system has already identified other problem areas and provided valuable information about hearth drainage patterns. This information has allowed them to develop control strategies to manage localized problem areas.

  8. Repair processes and radiation quality in neoplastic transformation of mammalian cells

    SciTech Connect (OSTI)

    Han, A.; Hill, C.K.; Elkind, M.M.

    1984-08-01

    Appropriate in vitro mammalian cell systems facilitate the study of cellular mechanisms of radiation oncogenesis. C3H 10T1/2 cells derived from mouse embryo have been used to study the effects of protracted irradiation on cell killing and incidence of neoplastic transformation. Protracted exposures of /sup 60/Co ..gamma.. rays or fission-spectrum neutrons (from the JANUS reactor at the Argonne National Laboratory) were given either at low dose rates or as multifractionated regimens using high dose rates. Dose protraction of ..gamma.. rays by multifractionation at a high dose rate (50 rad/min) results in appreciable reduction in cell killing and also significantly reduces the incidence of neoplastic transformation. Irradiation at a low dose rate has the same qualitative effect. In contrast, protracted exposures of fission-spectrum neutrons, given at a low dose rate (0.086 or 0.43 rad/min), result in significant enhancement of the frequency of transformation in the dose region of up to 80 rad. However, the survival of cells is essentially the same as that for the same single dose of neutrons given at a high dose rate. These observations are consistent with net ''error-free'' repair of transformational damage following protracted exposure of a low LET radiation and possibly a net ''error-prone'' repair of transformational damage after protracted irradiations with fission-spectrum neutrons.

  9. Operational results of shaft repair by installing stave type cooler at Kimitsu Nos. 3 and 4 blast furnaces

    SciTech Connect (OSTI)

    Oda, Hiroshi; Amano, Shigeru; Sakamoto, Aiichiro; Anzai, Osamu [Nippon Steel Corp., Kimitsu, Chiba (Japan). Kimitsu Works; Nakagome, Michiru; Kuze, Toshisuke [Nippon Steel Corp., Futtsu, Chiba (Japan); Imuta, Akira [Nippon Steel Corp., Tokyo (Japan). Plant and Machinery Div.

    1997-12-31

    Nos. 3 and 4 blast furnaces in Nippon Steel Corporation Kimitsu Works were both initially fitted with cooling plate systems. With the aging of each furnace, the damage to their respective inner-shaft profiles had become serious. Thus, in order to prevent operational change and prolong the furnace life, the inner-shaft profile of each furnace was repaired by replacing the former cooling plate system with the stave type cooler during the two-week-shutdowns. With this repair, stability of burden descent and gas flow near the wall part of the furnace have been achieved. Thus the prolongation of the furnace life is naturally expected.

  10. Exemption from Application of the Service Contract Act -Requirements UT-B Contracts Div Maintenance, Calibration, or Repair of Certain Equipment

    E-Print Network [OSTI]

    Maintenance, Calibration, or Repair of Certain Equipment Jan 2008 Page 1 of 1 exemp-sca-equip-requirement-ext-jan08.doc EXEMPTION FROM APPLICATION OF THE SERVICE CONTRACT ACT ­ MAINTENANCE, CALIBRATION, OR REPAIR quantities to the general public in the course of normal business operations. (b) The services shall

  11. Exemption from Application of the Service Contract Act -Certification UT-B Contracts Div Maintenance, Calibration, or Repair of Certain Equipment

    E-Print Network [OSTI]

    Maintenance, Calibration, or Repair of Certain Equipment Mar 2009 Page 1 of 1 exemp-sca-equip-certification-ext-venx-mar09.doc EXEMPTION FROM APPLICATION OF THE SERVICE CONTRACT ACT ­ MAINTENANCE, CALIBRATION, OR REPAIR in the course of normal business operations. (2) The services will be furnished at prices which are

  12. Effective Field Theory of Emergent Symmetry Breaking in Deformed Atomic Nuclei

    E-Print Network [OSTI]

    T. Papenbrock; H. A. Weidenmüller

    2015-05-07

    Spontaneous symmetry breaking in non-relativistic quantum systems has previously been addressed in the framework of effective field theory. Low-lying excitations are constructed from Nambu-Goldstone modes using symmetry arguments only. We extend that approach to finite systems. The approach is very general. To be specific, however, we consider atomic nuclei with intrinsically deformed ground states. The emergent symmetry breaking in such systems requires the introduction of additional degrees of freedom on top of the Nambu-Goldstone modes. Symmetry arguments suffice to construct the low-lying states of the system. In deformed nuclei these are vibrational modes each of which serves as band head of a rotational band.

  13. The response of plasma density to breaking inertial gravity wave in the lower regions of ionosphere

    SciTech Connect (OSTI)

    Tang, Wenbo Mahalov, Alex

    2014-04-15

    We present a three-dimensional numerical study for the E and lower F region ionosphere coupled with the neutral atmosphere dynamics. This model is developed based on a previous ionospheric model that examines the transport patterns of plasma density given a prescribed neutral atmospheric flow. Inclusion of neutral dynamics in the model allows us to examine the charge-neutral interactions over the full evolution cycle of an inertial gravity wave when the background flow spins up from rest, saturates and eventually breaks. Using Lagrangian analyses, we show the mixing patterns of the ionospheric responses and the formation of ionospheric layers. The corresponding plasma density in this flow develops complex wave structures and small-scale patches during the gravity wave breaking event.

  14. Modulational instability, wave breaking and formation of large scale dipoles in the atmosphere

    E-Print Network [OSTI]

    A. Iafrati; A. Babanin; M. Onorato

    2012-08-27

    In the present Letter we use the Direct Numerical Simulation (DNS) of the Navier-Stokes equation for a two-phase flow (water and air) to study the dynamics of the modulational instability of free surface waves and its contribution to the interaction between ocean and atmosphere. If the steepness of the initial wave is large enough, we observe a wave breaking and the formation of large scale dipole structures in the air. Because of the multiple steepening and breaking of the waves under unstable wave packets, a train of dipoles is released and propagate in the atmosphere at a height comparable with the wave length. The amount of energy dissipated by the breaker in water and air is considered and, contrary to expectations, we observe that the energy dissipation in air is larger than the one in the water. Possible consequences on the wave modelling and on the exchange of aerosols and gases between air and water are discussed.

  15. Twisted spectral triple for the Standard Model and spontaneous breaking of the Grand Symmetry

    E-Print Network [OSTI]

    Agostino Devastato; Pierre Martinetti

    2015-01-29

    Grand symmetry models in noncommutative geometry have been introduced to explain how to generate minimally (i.e. without adding new fermions) an extra scalar field beyond the standard model, which both stabilizes the electroweak vacuum and makes the computation of the mass of the Higgs compatible with its experimental value. In this paper, we use Connes-Moscovici twisted spectral triples to cure a technical problem of the grand symmetry, that is the appearance together with the extra scalar field of unbounded vectorial terms. The twist makes these terms bounded and - thanks to a twisted version of the first-order condition that we introduce here - also permits to understand the breaking to the standard model as a dynamical process induced by the spectral action. This is a spontaneous breaking from a pre-geometric Pati-Salam model to the almost-commutative geometry of the standard model, with two Higgs-like fields: scalar and vector.

  16. Quantitative similarity analysis of small-break loss-of-coolant accident scenarios

    SciTech Connect (OSTI)

    Prosek, A.; Kljenak, I.; Mavko, B. [Univ. of Ljubljana (Slovenia). Jozef Stefan Inst.

    1996-07-01

    Classifications of small-break loss-of-coolant accidents based on objective quantitative similarity analysis are proposed. Accident scenarios were simulated in a two-loop pressurized water reactor plant with the RELAP5/MOD3.1 computer code for break sizes ranging from 1.27 cm (0.5 in.) to 15.2 cm (6 in.), with different availability of auxiliary feedwater system or reactor coolant pump trip delay. Similarities between different accident simulations were evaluated by comparing relevant time-dependent parameters with fast Fourier transform and correlation methods. Quantification of similarity between accident simulations could eventually lead to further development of the Code Scaling, Applicability and Uncertainty methodology.

  17. RADIAL DEPENDENCE OF THE FREQUENCY BREAK BETWEEN FLUID AND KINETIC SCALES IN THE SOLAR WIND FLUCTUATIONS

    SciTech Connect (OSTI)

    Bruno, R.; Trenchi, L.

    2014-06-01

    We investigate the radial dependence of the spectral break separating the inertial from the dissipation range in power density spectra of interplanetary magnetic field fluctuations, between 0.42 and 5.3 AU, during radial alignments between MESSENGER and WIND for the inner heliosphere and between WIND and ULYSSES for the outer heliosphere. We found that the spectral break moves to higher and higher frequencies as the heliocentric distance decreases. The radial dependence of the corresponding wavenumber is of the kind ? {sub b} ? R {sup –1.08}, in good agreement with that of the wavenumber derived from the linear resonance condition for proton cyclotron damping. These results support conclusions from previous studies which suggest that a cyclotron-resonant dissipation mechanism must participate in the spectral cascade together with other possible kinetic noncyclotron-resonant mechanisms.

  18. Vacuum Bellows, Vacuum Piping, Cryogenic Break, and Copper Joint Failure Rate Estimates for ITER Design Use

    SciTech Connect (OSTI)

    L. C. Cadwallader

    2010-06-01

    The ITER international project design teams are working to produce an engineering design in preparation for construction of the International Thermonuclear Experimental Reactor (ITER) tokamak. During the course of this work, questions have arisen in regard to safety barriers and equipment reliability as important facets of system design. The vacuum system designers have asked several questions about the reliability of vacuum bellows and vacuum piping. The vessel design team has asked about the reliability of electrical breaks and copper-copper joints used in cryogenic piping. Research into operating experiences of similar equipment has been performed to determine representative failure rates for these components. The following chapters give the research results and the findings for vacuum system bellows, power plant stainless steel piping (amended to represent vacuum system piping), cryogenic system electrical insulating breaks, and copper joints.

  19. Translational Symmetry Breaking in Higgs & Gauge Theory, and the Cosmological Constant

    E-Print Network [OSTI]

    Evans, Nick; Scott, Marc

    2015-01-01

    We argue, at a very basic effective field theory level, that higher dimension operators in scalar theories that break symmetries at scales close to their ultraviolet completion cutoff, include terms that favour the breaking of translation (Lorentz) invariance, potentially resulting in striped, chequered board or general crystal-like phases. Such descriptions can be thought of as the effective low energy description of QCD-like gauge theories near their strong coupling scale where terms involving higher dimension operators are generated. Our low energy theory consists of scalar fields describing operators such as $\\bar{q} q$ and $\\bar{q} F^{(2n)} q$. Such scalars can have kinetic mixing terms that generate effective momentum dependent contributions to the mass matrix. We show that these can destabilize the translationally invariant vacuum. It is possible that in some real gauge theory such operators could become sufficiently dominant to realize such phases and it would be interesting to look for them in lattic...

  20. Breaking of relativistically intense longitudinal space charge waves: A description using Dawson sheet model

    SciTech Connect (OSTI)

    Sengupta, Sudip, E-mail: sudip@ipr.res.in [Institute for Plasma Research, Bhat , Gandhinagar - 382428 (India)

    2014-02-11

    Spatio-temporal evolution of relativistically intense longitudinal space charge waves in a cold homogeneous plasma is studied analytically as well as numerically, as an initial value problem, using Dawson sheet model. It is found that, except for very special initial conditions which generates the well known longitudinal Akhiezer-Polovin mode, for all other initial conditions, the waves break through a novel mechanism called phase mixing at an amplitude well below the Akhiezer-Polovin limit. An immediate consequence of this is, that Akhiezer-Polovin waves break when subjected to arbitrarily small longitudinal perturbations. We demonstrate this by performing extensive numerical simulations. This result may be of direct relevance to ultrashort, ultraintense laser/beam pulse-plasma interaction experiments where relativistically intense waves are routinely excited.

  1. Jet-induced 2-D crater formation with horizontal symmetry breaking

    E-Print Network [OSTI]

    Abram H. Clark; Robert P. Behringer

    2013-09-04

    We investigate the formation of a crater in a 2-D bed of granular material by a jet of impinging gas, motivated by the problem of a retrograde rocket landing on a planetary surface. The crater is characterized in terms of depth and shape as it evolves, as well as by the horizontal position of the bottom of the crater. The crater tends to grow logarithmically in time, a result which is common in related experiments. We also observe a horizontal symmetry breaking at certain well-defined conditions which, as we will demonstrate, could be of considerable practical concern for lunar or planetary landers. We present data on the evolution of these asymmetric states and attempt to give insights into the mechanism behind the symmetry-breaking bifurcation.

  2. A Free Energy Landscape for Cage Breaking of Three Hard Disks

    E-Print Network [OSTI]

    Gary L. Hunter; Eric R. Weeks

    2011-12-21

    We investigate cage breaking in dense hard disk systems using a model of three Brownian disks confined within a circular corral. This system has a six-dimensional configuration space, but can be equivalently thought to explore a symmetric one-dimensional free energy landscape containing two energy minima separated by an energy barrier. The exact free energy landscape can be calculated as a function of system size. Results of simulations show the average time between cage breaking events follows an Arrhenius scaling when the energy barrier is large. We also discuss some of the consequences of using a one-dimensional representation to understand dynamics in a multi-dimensional space, such as diffusion acquiring spatial dependence and discontinuities in spatial derivatives of free energy.

  3. Nikon Instruments Inc. | Resource Center -Research Papers -New insights into DNA repair http://www.nikoninstruments.com/Resource-Center/Research-Papers/New-insights-into-DNA-repair[4/10/2012 10:42:30 AM

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Nikon Instruments Inc. | Resource Center - Research Papers - New insights into DNA repair http:42:30 AM] change locationAMS EN Nikon Instruments Inc. on Facebook Like You like th Page · Ins Resource constrain available 3D conformations and slow the rate of homologous pairing while longer ssDNA strands

  4. Loss of feed flow, steam generator tube rupture and steam line break thermohydraulic experiments

    SciTech Connect (OSTI)

    Mendler, O J; Takeuchi, K; Young, M Y

    1986-10-01

    The Westinghouse Model Boiler No. 2 (MB-2) steam generator test model at the Engineering Test Facility in Tampa, Florida, was reinstrumented and modified for performing a series of tests simulating steam generator accident transients. The transients simulated were: loss of feed flow, steam generator tube rupture, and steam line break events. This document presents a description of (1) the model boiler and the associated test facility, (2) the tests performed, and (3) the analyses of the test results.

  5. Recent progress for Linear Collider SM/BSM Higgs/Electroweak Symmetry Breaking Calculations

    E-Print Network [OSTI]

    Juergen Reuter

    2012-01-22

    In this paper I review the calculations (and partially simulations and theoretical studies) that have been made and published during the last two to three years focusing on the electroweak symmetry breaking sector and the Higgs boson(s) within the Standard Model and models beyond the Standard Model (BSM) at or relevant for either the International Linear Collider (ILC) or the Compact Linear Collider (CLIC), commonly abbreviated as Linear Collider (LC).

  6. On the breaking and restoration of symmetries within the nuclear energy density functional formalism

    E-Print Network [OSTI]

    T. Duguet; J. Sadoudi

    2010-10-19

    We review the notion of symmetry breaking and restoration within the frame of nuclear energy density functional methods. We focus on key differences between wave-function- and energy-functional-based methods. In particular, we point to difficulties encountered within the energy functional framework and discuss new potential constraints on the underlying energy density functional that could make the restoration of broken symmetries better formulated within such a formalism. We refer to Ref.~\\cite{duguet10a} for details.

  7. Watching Hydrogen Bonds Break: A Transient Absorption Study of Water Tobias Steinel, John B. Asbury, Junrong Zheng, and M. D. Fayer*

    E-Print Network [OSTI]

    Fayer, Michael D.

    Watching Hydrogen Bonds Break: A Transient Absorption Study of Water Tobias Steinel, John B. Asbury of picoseconds, observe hydrogen bond breaking and monitor the equilibration of the hydrogen bond network in water. In addition, the vibrational lifetime, the time constant for hydrogen bond breaking, and the rate

  8. Impact of electromagnetism on phase structure for Wilson and twisted-mass fermions including isospin breaking

    E-Print Network [OSTI]

    Derek P. Horkel; Stephen R. Sharpe

    2015-05-09

    In a recent paper we used chiral perturbation theory to determine the phase diagram and pion spectrum for Wilson and twisted-mass fermions at non-zero lattice spacing with non-degenerate up and down quarks. Here we extend this work to include the effects of electromagnetism, so that it is applicable to recent simulations incorporating all sources of isospin breaking. For Wilson fermions, we find that the phase diagram is unaffected by the inclusion of electromagnetism---the only effect is to raise the charged pion masses. For maximally twisted fermions, we previously took the twist and isospin-breaking directions to be different, in order that the fermion determinant is real and positive. However, this is incompatible with electromagnetic gauge invariance, and so here we take the twist to be in the isospin-breaking direction, following the RM123 collaboration. We map out the phase diagram in this case, which has not previously been studied. The results differ from those obtained with different twist and isospin directions. One practical issue when including electromagnetism is that the critical masses for up and down quarks differ. We show that one of the criteria suggested to determine these critical masses does not work, and propose an alternative.

  9. Impact of electromagnetism on phase structure for Wilson and twisted-mass fermions including isospin breaking

    E-Print Network [OSTI]

    Derek P. Horkel; Stephen R. Sharpe

    2015-09-25

    In a recent paper we used chiral perturbation theory to determine the phase diagram and pion spectrum for Wilson and twisted-mass fermions at non-zero lattice spacing with non-degenerate up and down quarks. Here we extend this work to include the effects of electromagnetism, so that it is applicable to recent simulations incorporating all sources of isospin breaking. For Wilson fermions, we find that the phase diagram is unaffected by the inclusion of electromagnetism---the only effect is to raise the charged pion masses. For maximally twisted fermions, we previously took the twist and isospin-breaking directions to be different, in order that the fermion determinant is real and positive. However, this is incompatible with electromagnetic gauge invariance, and so here we take the twist to be in the isospin-breaking direction, following the RM123 collaboration. We map out the phase diagram in this case, which has not previously been studied. The results differ from those obtained with different twist and isospin directions. One practical issue when including electromagnetism is that the critical masses for up and down quarks differ. We show that one of the criteria suggested to determine these critical masses does not work, and propose an alternative.

  10. Head/tail Breaks for Visualization of City Structure and Dynamics

    E-Print Network [OSTI]

    Jiang, Bin

    2015-01-01

    The things surrounding us vary dramatically, which implies that there are far more small things than large ones, e.g., far more small cities than large ones in the world. This dramatic variation is often referred to as fractal or scaling. To better reveal the fractal or scaling structure, a new classification scheme, namely head/tail breaks, has been developed to recursively derive different classes or hierarchical levels. The head/tail breaks works as such: divide things into a few large ones in the head (those above the average) and many small ones (those below the average) in the tail, and recursively continue the dividing process for the large ones (or the head) until the notion of far more small things than large ones has been violated. This paper attempts to argue that head/tail breaks can be a powerful visualization tool for illustrating structure and dynamics of natural cities. Natural cities refer to naturally or objectively defined human settlements based on a meaningful cutoff averaged from a massi...

  11. Light scalar as the messenger of electroweak and flavor symmetry breaking

    SciTech Connect (OSTI)

    Lykken, J. D. [Theoretical Physics Department, Fermilab, P.O. Box 500, Batavia, Illinois 60510 (United States); Murdock, Z. [Department of Physics and Oklahoma Center for High Energy Physics, Oklahoma State University, Stillwater, Oklahoma 74078 (United States); Nandi, S. [Theoretical Physics Department, Fermilab, P.O. Box 500, Batavia, Illinois 60510 (United States); Department of Physics and Oklahoma Center for High Energy Physics, Oklahoma State University, Stillwater, Oklahoma 74078 (United States)

    2009-04-01

    We propose a new framework for understanding the hierarchies of fermion masses and mixings. The masses and mixings of all standard model (SM) charged fermions other than top arise from higher dimensional operators involving a messenger scalar S and flavon scalars F{sub i}. The flavons spontaneously break SM flavor symmetries at around the TeV scale. The SM singlet scalar S couples directly to the Higgs H and spontaneously breaks another U(1) at the electroweak scale. At the TeV scale, SM quarks and charged leptons have renormalizable couplings to S, but not to H or F{sub i}. These couplings involve new heavy vectorlike fermions. Integrating out these fermions produces a pattern of higher dimensional operators that reproduce the observed hierarchies of the SM masses and mixings in terms of powers of the 'little hierarchy': the ratio of the electroweak scale to the flavor-breaking scale. The framework has important phenomenological implications. Flavor-changing neutral currents are within experimental limits but D{sup 0}-D{sup 0} mixing and B{sub s}{yields}{mu}{sup +}{mu}{sup -} could be close to current sensitivities. The neutral scalar s of the messenger field mixes with the light Higgs of the SM, which can have strong effects on Higgs decay branching fractions. The s mass eigenstate may be lighter than the Higgs, and could be detected at the Tevatron or the LHC.

  12. Published on Science 2.0 (http://www.science20.com) Home > Life Sciences > Genetics & Molecular Biology > News Articles > Rad51: Watching Single Strands Of DNA Being Prepped For Repair Could Help Fight Breast Cancer

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Biology > News Articles > Rad51: Watching Single Strands Of DNA Being Prepped For Repair Could Help Fight Breast Cancer Rad51: Watching Single Strands Of DNA Being Prepped For Repair Could Help Fight Breast: Watching Single Strands Of DNA Being Prepped For Repair Could Help Fight Br... 6/17/2013http

  13. Drilling and Microfracture Lead to Different Bone Structure and Necrosis during Bone-Marrow Stimulation for Cartilage Repair

    E-Print Network [OSTI]

    Buschmann, Michael

    Drilling and Microfracture Lead to Different Bone Structure and Necrosis during Bone following microfracture and comparing to drilling in a mature rabbit model of cartilage repair. Microfracture holes were made to a depth of 2 mm and drill holes to either 2 mm or 6 mm under cooled irrigation

  14. Image-Guided Techniques Improve the Short-term Outcome of Autologous Osteochondral Cartilage Repair Surgeries -An

    E-Print Network [OSTI]

    Stewart, James

    Image-Guided Techniques Improve the Short-term Outcome of Autologous Osteochondral Cartilage Repair and deliver osteochondral grafts remains problematic. We investigated whether image-guided methods (optically-guided and template-guided) can improve the outcome of mo- saic arthroplasty procedures. Methods: Fifteen sheep were

  15. Direct observations of DNA provides new insights into how genetic material is copied and repaired News-Medical.Net

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Direct observations of DNA provides new insights into how genetic material is copied and repaired News-Medical.Net · Home Page Direct observations of DNA provides new insights into how genetic material to a Friend Direct observations of DNA are giving new insights into how genetic material is copied

  16. Global-to-Local Rule Generation for Self-Assembly and Self-Repair by Robot Swarms

    E-Print Network [OSTI]

    Southern California, University of

    Global-to-Local Rule Generation for Self-Assembly and Self-Repair by Robot Swarms Daniel Arbuckle a reactive self-assembly technique intended for use in swarms of simple robots, the other a distributed in the possibility that swarms of general-purpose self-assembling robots might be used to replace many such objects

  17. International Journal of Adhesion & Adhesives 26 (2006) 314324 Dynamic response of a repaired composite beam with an adhesively

    E-Print Network [OSTI]

    Vaziri, Ashkan

    2006-01-01

    International Journal of Adhesion & Adhesives 26 (2006) 314­324 Dynamic response of a repaired composite beam with an adhesively bonded patch under a harmonic peeling load A. Vaziri1 , H. Nayeb with adhesive. In the theoretical part, the equations of motion in the axial and transverse directions were

  18. Charge-transport-mediated recruitment of DNA repair enzymes Pak-Wing Fok,1,2,a

    E-Print Network [OSTI]

    Levine, Alex J.

    Charge-transport-mediated recruitment of DNA repair enzymes Pak-Wing Fok,1,2,a Chin-Lin Guo,3 and Tom Chou2,4,b 1 Applied and Computational Mathematics, California Institute of Technology, Pasadena, California 91125, USA 2 Department of Biomathematics, UCLA, Los Angeles, California 90095-1766, USA 3 Applied

  19. Method and apparatus for in-system redundant array repair on integrated circuits

    DOE Patents [OSTI]

    Bright, Arthur A. (Croton-on-Hudson, NY); Crumley, Paul G. (Yorktown Heights, NY); Dombrowa, Marc B. (Bronx, NY); Douskey, Steven M. (Rochester, MN); Haring, Rudolf A. (Cortlandt Manor, NY); Oakland, Steven F. (Colchester, VT); Ouellette, Michael R. (Westford, VT); Strissel, Scott A. (Byron, MN)

    2008-07-08

    Disclosed is a method of repairing an integrated circuit of the type comprising of a multitude of memory arrays and a fuse box holding control data for controlling redundancy logic of the arrays. The method comprises the steps of providing the integrated circuit with a control data selector for passing the control data from the fuse box to the memory arrays; providing a source of alternate control data, external of the integrated circuit; and connecting the source of alternate control data to the control data selector. The method comprises the further step of, at a given time, passing the alternate control data from the source thereof, through the control data selector and to the memory arrays to control the redundancy logic of the memory arrays.

  20. Method and apparatus for in-system redundant array repair on integrated circuits

    DOE Patents [OSTI]

    Bright, Arthur A. (Croton-on-Hudson, NY); Crumley, Paul G. (Yorktown Heights, NY); Dombrowa, Marc B. (Bronx, NY); Douskey, Steven M. (Rochester, MN); Haring, Rudolf A. (Cortlandt Manor, NY); Oakland, Steven F. (Colchester, VT); Ouellette, Michael R. (Westford, VT); Strissel, Scott A. (Byron, MN)

    2007-12-18

    Disclosed is a method of repairing an integrated circuit of the type comprising of a multitude of memory arrays and a fuse box holding control data for controlling redundancy logic of the arrays. The method comprises the steps of providing the integrated circuit with a control data selector for passing the control data from the fuse box to the memory arrays; providing a source of alternate control data, external of the integrated circuit; and connecting the source of alternate control data to the control data selector. The method comprises the further step of, at a given time, passing the alternate control data from the source thereof, through the control data selector and to the memory arrays to control the redundancy logic of the memory arrays.

  1. Method and apparatus for in-system redundant array repair on integrated circuits

    DOE Patents [OSTI]

    Bright, Arthur A. (Croton-on-Hudson, NY); Crumley, Paul G. (Yorktown Heights, NY); Dombrowa, Marc B. (Bronx, NY); Douskey, Steven M. (Rochester, MN); Haring, Rudolf A. (Cortlandt Manor, NY); Oakland, Steven F. (Colchester, VT); Ouellette, Michael R. (Westford, VT); Strissel, Scott A. (Byron, MN)

    2008-07-29

    Disclosed is a method of repairing an integrated circuit of the type comprising of a multitude of memory arrays and a fuse box holding control data for controlling redundancy logic of the arrays. The method comprises the steps of providing the integrated circuit with a control data selector for passing the control data from the fuse box to the memory arrays; providing a source of alternate control data, external of the integrated circuit; and connecting the source of alternate control data to the control data selector. The method comprises the further step of, at a given time, passing the alternate control data from the source thereof, through the control data selector and to the memory arrays to control the redundancy logic of the memory arrays.

  2. Design structure for in-system redundant array repair in integrated circuits

    DOE Patents [OSTI]

    Bright, Arthur A.; Crumley, Paul G.; Dombrowa, Marc; Douskey, Steven M.; Haring, Rudolf A.; Oakland, Steven F.; Quellette, Michael R.; Strissel, Scott A.

    2008-11-25

    A design structure for repairing an integrated circuit during operation of the integrated circuit. The integrated circuit comprising of a multitude of memory arrays and a fuse box holding control data for controlling redundancy logic of the arrays. The design structure provides the integrated circuit with a control data selector for passing the control data from the fuse box to the memory arrays; providing a source of alternate control data, external of the integrated circuit; and connecting the source of alternate control data to the control data selector. The design structure further passes the alternate control data from the source thereof, through the control data selector and to the memory arrays to control the redundancy logic of the memory arrays.

  3. Inhibition of B-NHEJ in Plateau-Phase Cells Is Not a Direct Consequence of Suppressed Growth Factor Signaling

    SciTech Connect (OSTI)

    Singh, Satyendra K.; Bednar, Theresa; Zhang Lihua; Wu, Wenqi; Mladenov, Emil; Iliakis, George

    2012-10-01

    Purpose: It has long been known that the proliferation status of a cell is a determinant of radiation response, and the available evidence implicates repair of DNA double-strand breaks (DSBs) in the underlying mechanism. Recent results have shown that a novel, highly error-prone pathway of nonhomologous end joining (NHEJ) operating as backup (B-NHEJ) processes DSBs in irradiated cells when the canonical, DNA-PK (DNA-dependent protein kinase)-dependent pathway of NHEJ (D-NHEJ) is compromised. Notably, B-NHEJ shows marked reduction in efficiency when D-NHEJ-deficient cells cease to grow and enter a plateau phase. This phenomenon is widespread and observed in cells of different species with defects in core components of D-NHEJ, with the notable exception of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit). Using new, standardized serum-deprivation protocols, we re-examine the growth requirements of B-NHEJ and test the role of epidermal growth factor receptor (EGFR) signaling in its regulation. Methods and Materials: DSB repair was measured by pulsed-field gel electrophoresis in cells maintained under different conditions of growth. Results: Serum deprivation in D-NHEJ-deficient cells causes a rapid reduction in B-NHEJ similar to that measured in normally growing cells that enter the plateau phase of growth. Upon serum deprivation, reduction in B-NHEJ activity is evident at 4 h and reaches a plateau reflecting maximum inhibition at 12-16 h. The inhibition is reversible, and B-NHEJ quickly recovers to the levels of actively growing cells upon supply of serum to serum-deprived cells. Chemical inhibition of EGFR in proliferating cells inhibits only marginally B-NHEJ and addition of EGFR in serum-deprived cells increases only a marginally B-NHEJ. Conclusions: The results document a rapid and fully reversible adaptation of B-NHEJ to growth activity and point to factors beyond EGFR in its regulation. They show notable differences in the regulation of error-prone DSB repair pathways between proliferating and non proliferating cells that may present new treatment design opportunities in radiation therapy.

  4. Introduction of Break-Out Session 2 of the 2011 International PV Module Quality Assurance Forum(Presentation)

    SciTech Connect (OSTI)

    Wohlgemuth, J.; Kurtz, S.; Sample, T.; Yamamichi, M.

    2011-07-01

    This presentation outlines the goals and specific tasks of break-out session 2 of the 2011 International PV Module Quality Assurance Forum, along with a review of accelerated stress tests used for photovoltaics (PV).

  5. TITAN code development for application to a PWR steam line break accident : final report 1983-1984

    E-Print Network [OSTI]

    Tsai, Chon-Kwo

    1984-01-01

    Modification of the TITAN computer code which enables it to be applied to a PWR steam line break accident has been accomplished. The code now has the capability of simulating an asymmetric inlet coolant temperature transient ...

  6. Mass-related inversion symmetry breaking and phonon self-energy renormalization in isotopically labeled AB-stacked bilayer graphene

    E-Print Network [OSTI]

    Araujo, Paulo Antonio Trinidade

    A mass-related symmetry breaking in isotopically labeled bilayer graphene (2LG) was investigated during in-situ electrochemical charging of AB stacked (AB-2LG) and turbostratic (t-2LG) layers. The overlap of the two ...

  7. Break-Even Cost for Residential Solar Water Heating in the United States: Key Drivers and Sensitivities

    SciTech Connect (OSTI)

    Cassard, H.; Denholm, P.; Ong, S.

    2011-02-01

    This paper examines the break-even cost for residential rooftop solar water heating (SWH) technology, defined as the point where the cost of the energy saved with a SWH system equals the cost of a conventional heating fuel purchased from the grid (either electricity or natural gas). We examine the break-even cost for the largest 1,000 electric and natural gas utilities serving residential customers in the United States as of 2008. Currently, the break-even cost of SWH in the United States varies by more than a factor of five for both electricity and natural gas, despite a much smaller variation in the amount of energy saved by the systems (a factor of approximately one and a half). The break-even price for natural gas is lower than that for electricity due to a lower fuel cost. We also consider the relationship between SWH price and solar fraction and examine the key drivers behind break-even costs. Overall, the key drivers of the break-even cost of SWH are a combination of fuel price, local incentives, and technical factors including the solar resource location, system size, and hot water draw.

  8. Updated TRAC analysis of an 80% double-ended cold-leg break for the AP600 design

    SciTech Connect (OSTI)

    Lime, J.F.; Boyack, B.E. [Los Alamos National Lab., NM (United States). Technology and Safety Assessment Div.

    1995-07-01

    An updated TRAC 80% large-break loss-of-coolant accident (LBLOCA) has been calculated for the Westinghouse AP600 advanced reactor design, The updated calculation incorporates major code error corrections, model corrections, and plant design changes. The 80% break size was calculated by Westinghouse to be the most severe large-break size for the AP600 design. The LBLOCA transient was calculated to 144 s. Peak cladding temperatures (PCTS) were well below the Appendix K limit of 1,478 K (2,200 F), but very near the cladding oxidation temperature of 1,200 K (1,700 F). Transient event times and PCT for the TRAC calculation were in reasonable agreement with those calculated by Westinghouse using their {und W}COBRA/TRAC code. However, there were significant differences in the detailed phenomena calculated by the two codes, particularly during the blowdown phase. The reasons for these differences are still being investigated. Additional break sizes and break locations need to be analyzed to confirm the most severe break postulated by Westinghouse.

  9. Sphericity and symmetry breaking in the formation of Frank–Kasper phases from one component materials

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lee, Sangwoo; Leighton, Chris; Bates, Frank S.

    2014-11-05

    Frank–Kasper phases are tetrahedrally packed structures occurring in numerous materials, from elements to intermetallics to self-assembled soft materials. They exhibit complex manifolds of Wigner–Seitz cells with many-faceted polyhedra, forming an important bridge between the simple close-packed periodic and quasiperiodic crystals. The recent discovery of the Frank–Kasper ?-phase in diblock and tetrablock polymers stimulated the experiments reported here on a poly(isoprene-b-lactide) diblock copolymer melt. Thus, analysis of small-angle X-ray scattering and mechanical spectroscopy exposes an undiscovered competition between the tendency to form self-assembled particles with spherical symmetry, and the necessity to fill space at uniform density within the framework imposed bymore »the lattice. We thus deduce surprising analogies between the symmetry breaking at the body-centered cubic phase to ?-phase transition in diblock copolymers, mediated by exchange of mass, and the symmetry breaking in certain metals and alloys (such as the elements Mn and U), mediated by exchange of charge. Similar connections are made between the role of sphericity in real space for polymer systems, and the role of sphericity in reciprocal space for metallic systems such as intermetallic compounds and alloys. These findings establish new links between disparate materials classes, provide opportunities to improve the understanding of complex crystallization by building on synergies between hard and soft matter, and, perhaps most significantly, challenge the view that the symmetry breaking required to form reduced symmetry structures (possibly even quasiperiodic crystals) requires particles with multiple predetermined shapes and/or sizes.« less

  10. Sphericity and symmetry breaking in the formation of Frank–Kasper phases from one component materials

    SciTech Connect (OSTI)

    Lee, Sangwoo; Leighton, Chris; Bates, Frank S.

    2014-11-05

    Frank–Kasper phases are tetrahedrally packed structures occurring in numerous materials, from elements to intermetallics to self-assembled soft materials. They exhibit complex manifolds of Wigner–Seitz cells with many-faceted polyhedra, forming an important bridge between the simple close-packed periodic and quasiperiodic crystals. The recent discovery of the Frank–Kasper ?-phase in diblock and tetrablock polymers stimulated the experiments reported here on a poly(isoprene-b-lactide) diblock copolymer melt. Thus, analysis of small-angle X-ray scattering and mechanical spectroscopy exposes an undiscovered competition between the tendency to form self-assembled particles with spherical symmetry, and the necessity to fill space at uniform density within the framework imposed by the lattice. We thus deduce surprising analogies between the symmetry breaking at the body-centered cubic phase to ?-phase transition in diblock copolymers, mediated by exchange of mass, and the symmetry breaking in certain metals and alloys (such as the elements Mn and U), mediated by exchange of charge. Similar connections are made between the role of sphericity in real space for polymer systems, and the role of sphericity in reciprocal space for metallic systems such as intermetallic compounds and alloys. These findings establish new links between disparate materials classes, provide opportunities to improve the understanding of complex crystallization by building on synergies between hard and soft matter, and, perhaps most significantly, challenge the view that the symmetry breaking required to form reduced symmetry structures (possibly even quasiperiodic crystals) requires particles with multiple predetermined shapes and/or sizes.

  11. Charge Symmetry Breaking in the Nucleon and Parity Violating Elastic Electron-Proton Scattering

    E-Print Network [OSTI]

    Gerald A. Miller

    2014-10-31

    The basic facts of charge symmetry breaking (CSB) phenomena are reviewed. The relevance of CSB to parity-violating electron-proton scattering experiments that seek to extract strange elastic form factors is discussed. Experimentalists have stated and written that the current uncertainty in our knowledge of CSB limits the ability to push further on the strange form factors. I discuss recent calculations using relativistic chiral perturbation theory and realistic values of strong coupling constants which show that the uncertainties due to lack of knowledge of CSB are at least ten times smaller than present experimental uncertainties. Estimates of CSB effects are made for the JLab Qweak and Mainz P2 experiments.

  12. Gauge-invariant signatures of spontaneous gauge symmetry breaking by the Hosotani mechanism

    E-Print Network [OSTI]

    Oscar Akerlund; Philippe de Forcrand

    2015-03-02

    The Hosotani mechanism claims to achieve gauge-symmetry breaking, for instance $SU(3) \\to SU(2)\\times U(1)$. To verify this claim, we propose to monitor the stability of a topological defect stable under a gauge subgroup but not under the whole gauge group, like a $U(1)$ flux state or monopole in the case above. We use gauge invariant operators to probe the presence of the topological defect to avoid any ambiguity introduced by gauge fixing. Our method also applies to an ordinary gauge-Higgs system.

  13. Charge independence, charge symmetry breaking in the S-wave nucleon-nucleon interaction, and renormalization

    SciTech Connect (OSTI)

    Alvaro Calle Cordon,Manuel Pavon Valderrama,Enrique Ruiz Arriola

    2012-02-01

    We study the interplay between charge symmetry breaking and renormalization in the NN system for S-waves. We find a set of universality relations which disentangle explicitly the known long distance dynamics from low energy parameters and extend them to the Coulomb case. We analyze within such an approach the One-Boson-Exchange potential and the theoretical conditions which allow to relate the proton-neutron, proton-proton and neutron-neutron scattering observables without the introduction of extra new parameters and providing good phenomenological success.

  14. TACIS 91: Application of leak-before-break concept in VVER 440-230

    SciTech Connect (OSTI)

    Bartholome, G.; Faidy, C.; Franco, C.

    1997-04-01

    The applicability of the leak-before-break (LBB) concept for primary piping in the first generation of WWER type plants in Russia is investigated. The procedures for LBB behavior used in France and Germany are applied, and the evaluation is discussed within the framework of the European Technical Assistance for the Community of Independent States (TACIS) project. Emphasis is placed on experimental validation of national and international engineering practice for evaluating and optimizing existing installations. Design criteria of WWER plants are compared to western standard design.

  15. On Uplifted SUSY-Breaking Vacua and Direct Mediation in Generalized SQCD

    E-Print Network [OSTI]

    Roberto Auzzi; Shmuel Elitzur; Amit Giveon

    2010-03-21

    We search for viable models of direct gauge mediation, where the SUSY-breaking sector is (generalized) SQCD, which has cosmologically favorable uplifted vacua even when the reheating temperature is well above the messenger scale. This requires a relatively large tadpole term in the scalar potential for the spurion field X and, consequently, we argue that pure (deformed) SQCD is not a viable model. On the other hand, in SQCD with an adjoint, which is natural e.g. in string theory, assuming an appropriate sign in the Kahler potential for X, such metastable vacua are possible.

  16. Colorful plane vortices and Chiral Symmetry Breaking in $SU(2)$ Lattice Gauge Theory

    E-Print Network [OSTI]

    Seyed Mohsen Hosseini Nejad; Manfried Faber; Roman Höllwieser

    2015-08-11

    We investigate plane vortices with color structure. The topological charge and gauge action of such colorful plane vortices are studied in the continuum and on the lattice. These configurations are vacuum to vacuum transitions changing the winding number between the two vacua, leading to a topological charge $Q=-1$ in the continuum. After growing temporal extent of these vortices, the lattice topological charge approaches $-1$ and the index theorem is fulfilled. We analyze the low lying modes of the overlap Dirac operator in the background of these colorful plane vortices and compare them with those of spherical vortices. They show characteristic properties for spontaneous chiral symmetry breaking.

  17. Colorful plane vortices and Chiral Symmetry Breaking in $SU(2)$ Lattice Gauge Theory

    E-Print Network [OSTI]

    Seyed Mohsen Hosseini Nejad; Manfried Faber; Roman Höllwieser

    2015-08-05

    We investigate plane vortices with color structure. The topological charge and gauge action of such colorful plane vortices are studied in the continuum and on the lattice. These configurations are vacuum to vacuum transitions changing the winding number between the two vacua, leading to a topological charge $Q=-1$ in the continuum. After growing temporal extent of these vortices, the lattice topological charge approaches $-1$ and the index theorem is fulfilled. We analyze the low lying modes of the overlap Dirac operator in the background of these colorful plane vortices and compare them with those of spherical vortices. They show characteristic properties for spontaneous chiral symmetry breaking.

  18. The Stick-Breaking Construction of the Beta Process as a Poisson Process

    E-Print Network [OSTI]

    Paisley, John; Jordan, Michael I

    2011-01-01

    We show that the stick-breaking construction of the beta process due to Paisley et al. (2010) can be obtained from the characterization of the beta process as a Poisson process. This is achieved by showing that the mean measure of the underlying Poisson process is equal to that of the beta process. We then present a number of consequences of this derivation; in particular, we show how it can be used to derive error bounds on truncated beta processes that are significantly tighter than those in the literature.

  19. Numerical modeling of boundary layer flow under shoaling and breaking waves 

    E-Print Network [OSTI]

    Pattipawaej, Olga Catherina

    1998-01-01

    velocities and shear stresses in the bottom boundary layer under breaking waves. The experiment wss conducted in the Precision Wave Tank located in the Ocean Engineering Laboratory at the University of Delaware. The flume was 33 m long, 0. 6 m wide, and 1... modeling of surf zone hydrodynamics. " Rep. No. CACR-95-97, Center for Applied Coastal Research, University Delaware, Newark, Delaware. Cox, D. T. , Kobayashi, N. , and Okayasu, A. (1996). "Bottom shear stress in the surf zone. " J. Geophys. Res. , 101(C...

  20. Colorful plane vortices and Chiral Symmetry Breaking in $SU(2)$ Lattice Gauge Theory

    E-Print Network [OSTI]

    Seyed Mohsen Hosseini Nejad; Manfried Faber; Roman Höllwieser

    2015-09-25

    We investigate plane vortices with color structure. The topological charge and gauge action of such colorful plane vortices are studied in the continuum and on the lattice. These configurations are vacuum to vacuum transitions changing the winding number between the two vacua, leading to a topological charge $Q=-1$ in the continuum. After growing temporal extent of these vortices, the lattice topological charge approaches $-1$ and the index theorem is fulfilled. We analyze the low lying modes of the overlap Dirac operator in the background of these colorful plane vortices and compare them with those of spherical vortices. They show characteristic properties for spontaneous chiral symmetry breaking.