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1

Global methylation responses to low dose radiation exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

methylation responses to low dose radiation exposure methylation responses to low dose radiation exposure Pamela J Sykes, Michelle R Newman, Benjamin J Blyth and Rebecca J Ormsby Haematology and Genetic Pathology, Flinders University and Medical Centre, Flinders Centre for Cancer Prevention and Control, Bedford Park, Adelaide, South Australia 5042 Australia. (pam.sykes@flinders.edu.au). Our goal is to study the mechanisms involved in biological responses to low doses of radiation in vivo in the dose range that is relevant to population and occupational exposures. At high radiation doses, DNA double-strand breaks are considered the critical lesion underlying the initiation of radiation-induced carcinogenesis. However, at the very low radiation doses relevant for the general public, the induction of DNA double-strand breaks

2

Low Dose Radiation Exposure: Exploring Bystander Effects In Vivo.  

NLE Websites -- All DOE Office Websites (Extended Search)

Exposure: Exploring Bystander Effects Exposure: Exploring Bystander Effects In Vivo. 1 Blyth, B.J., 1 Sykes, P.J. 1 Department of Haematology and Genetic Pathology, Flinders University and Medical Centre, Bedford Park, South Australia, 5042, The general population is daily exposed to chronic, low doses of ionizing radiation from both natural and artificial sources. The shape of the radiation dose-response curve at these low doses is currently linearly extrapolated from data obtained after high dose exposure due to the low sensitivity of traditional biological assays after near-background exposures. At odds with this Linear No-Threshold model, are the phenomena collectively referred to as the radiation-induced bystander effect. The bystander effect describes a collection of in vitro

3

Low dose diagnostic radiation exposure and cancer risk in Trp53...  

NLE Websites -- All DOE Office Websites (Extended Search)

University Abstract The cancer risk associated with exposure to low doses of ionizing radiation has traditionally been extrapolated from effects observed at high doses and high...

4

Risk equivalent of exposure versus dose of radiation  

SciTech Connect

This report describes a risk analysis study of low-dose irradiation and the resulting biological effects on a cell. The author describes fundamental differences between the effects of high-level exposure (HLE) and low-level exposure (LLE). He stresses that the concept of absorbed dose to an organ is not a dose but a level of effect produced by a particular number of particles. He discusses the confusion between a linear-proportional representation of dose limits and a threshold-curvilinear representation, suggesting that a LLE is a composite of both systems. (TEM)

Bond, V.P.

1986-01-01T23:59:59.000Z

5

Low dose diagnostic radiation exposure and cancer risk in Trp53+/- mice  

NLE Websites -- All DOE Office Websites (Extended Search)

diagnostic radiation exposure and cancer risk in Trp53+/- mice diagnostic radiation exposure and cancer risk in Trp53+/- mice K Taylor, N Phan, ME Cybulski, L Laframboise, DR Boreham Department of Medical Physics and Applied Radiation Sciences, McMaster University, 1280 Main Street West, Hamilton ON L8S 4K1 The cancer risk associated with exposure to low doses of ionizing radiation has traditionally been extrapolated from effects observed at high doses and high dose rates using a linear no threshold model. Based on this approach, it has been postulated that human exposure to medical imaging involving low doses of x-rays and gamma rays increase an individual's risk of developing cancer throughout their lifetime. Conversely, there is evidence that low doses of gamma radiation increase the latency period of cancer depending upon genotype, cancer type, and the magnitude of

6

Increased radiation dose at mammography due to prolonged exposure, delayed processing, and increased film darkening  

SciTech Connect

Four single-emulsion films introduced over the past 2 years--Du Pont Microvision, Fuji MiMa, Konica CM, and Eastman Kodak OM--were compared with Eastman Kodak OM SO-177 (Min-RE) film to evaluate their varying effects on mean glandular dose of reciprocity law failure due to prolonged exposure, delayed processing, and increased film darkening as a result of increased radiation exposure to improve penetration of glandular tissue. Exposures over 1.3 seconds led to increased radiation doses of 20%-30%. Delays in processing of 6 hours decreased processing speed by 11%-32% for all films except Du Pont Microvision. Optical density increases of 0.40 required 20%-30% more skin exposure for all five films. Optimal viewing densities were also evaluated and found to be different for each of the five films. Mammographers need to be aware of these differences in mammographic films to achieve maximum contrast at mammography.

Kimme-Smith, C.; Bassett, L.W.; Gold, R.H.; Chow, S. (UCLA Medical Center (USA))

1991-02-01T23:59:59.000Z

7

An evaluation of theories concerning the health effects of low-dose radiation exposures  

E-Print Network (OSTI)

The danger of high, acute doses of radiation is well documented, but the effects of low-dose radiation below 100 mSv is still heavily debated. Four theories concerning the effects of lowdose radiation are presented here: ...

Wei, Elizabeth J. (Elizabeth Jay)

2012-01-01T23:59:59.000Z

8

Individual Radiation Exposure Dose Due to Support Activities at Safe Shelters in Fukushima Prefecture  

E-Print Network (OSTI)

Immediately after the accidents in the nuclear power stations in Fukushima on March 11, the Japanese Government ordered the evacuation of the residents within a 20-km radius from the station on March 12, and asked various institutions to monitor the contamination levels of the residents. Hirosaki University, which is located 355 km north of Fukushima City, decided to send support staff to Fukushima. This report summarizes the results of the exposure of 13 individual teams from March 15 to June 20. The support teams surveyed more than 5,000 people during this period. Almost all subjects had external contamination levels of less than 13 kcpm on Geiger-Mller (GM) survey meter, which is categorized as no contamination level. The 1 st team showed the highest external exposure dose, but the 4 th team onward showed no significant change. Subsequently, the internal radiation exposure was measured using a whole body counter that indicated undetectable levels in all staff members. Although the measured external radiation exposure dose cannot have serious biological effects on the health of an individual, a follow-up study of the residents in Fukushima and other regions where

Satoru Monzen; Masahiro Hosoda; Shinji Tokonami; Minoru Osanai; Hironori Yoshino; Mitsuaki A. Yoshida; Masatoshi Yamada; Yasushi Asari; Kei Satoh; Ikuo Kashiwakura

2011-01-01T23:59:59.000Z

9

Estimation of Internal Radiation Dose from both Immediate Releases and Continued Exposures to Contaminated Materials  

Science Conference Proceedings (OSTI)

A brief description is provided of the basic concepts related to 'internal dose' and how it differs from doses that result from radioactive materials and direct radiation outside of the body. The principles of radiation dose reconstruction, as applied to both internal and external doses, is discussed based upon a recent publication prepared by the US National Council on Radiation Protection and Measurements. Finally, ideas are introduced related to residual radioactive contamination in the environment that has resulted from the releases from the damaged reactors and also to the management of wastes that may be generated in both regional cleanup and NPP decommissioning.

Napier, Bruce A.

2012-03-26T23:59:59.000Z

10

2011 DOE Occupational Radiation Exposure Summary poster  

SciTech Connect

This poster graphically presents data pertaining to occupational radiation exposure in terms of total effective dose (TED), primarily, but also collective dose and average measureable dose.

ORAU

2012-12-12T23:59:59.000Z

11

The risk equivalent of an exposure to-, versus a dose of radiation  

SciTech Connect

The long-term potential carcinogenic effects of low-level exposure (LLE) are addressed. The principal point discussed is linear, no-threshold dose-response curve. That the linear no-threshold, or proportional relationship is widely used is seen in the way in which the values for cancer risk coefficients are expressed - in terms of new cases, per million persons exposed, per year, per unit exposure or dose. This implies that the underlying relationship is proportional, i.e., ''linear, without threshold''. 12 refs., 9 figs., 1 tab.

Bond, V.P.

1986-01-01T23:59:59.000Z

12

Low Dose Radiation Research Program: Aloke Chatterjee  

NLE Websites -- All DOE Office Websites (Extended Search)

Chatterjee, A. and Holley, W.R. 1999 Workshop: Biological Effects of Low-Dose and Low-Dose-Rate Radiation Exposures: An Integrated Theoretical and Experimental Approach....

13

Low Dose Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Ancient Salt Beds Ancient Salt Beds Repository Science Renewable Energy The WIPP Underground may be ideal to study effects of Very Low Dose Rates on Biological Systems Low Background Radiation Experiment We're all bathing in it. It's in the food we eat, the water we drink, the soil we tread and even the air we breathe. It's background radiation, it's everywhere and we can't get away from it. But what would happen if you somehow "pulled the plug" on natural background radiation? Would organisms suffer or thrive if they grew up without their constant exposure to background radiation? That's what a consortium of scientists conducting an experiment at the Waste Isolation Pilot Plant aim to find out. Despite being an underground repository for transuranic radioactive waste,

14

Low Dose Radiation Research Program: Mohan Natarajan  

NLE Websites -- All DOE Office Websites (Extended Search)

of Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure Funded Project Real-Time Molecular Study of Bystander Effect Using...

15

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

SciTech Connect

Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

2008-06-06T23:59:59.000Z

16

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

SciTech Connect

Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

2008-06-06T23:59:59.000Z

17

Cell Type-dependent Gene Transcription Profile in Three Dimensional Human Skin Tissue Model Exposed to Low Doses of Ionizing Radiation: Implications for Medical Exposures  

SciTech Connect

The concern over possible health risks from exposures to low doses of ionizing radiation has been driven largely by the increase in medical exposures, the routine implementation of X-ray backscatter devices for airport security screening, and, most recently, the nuclear incident in Japan. Due to a paucity of direct epidemiological data at very low doses, cancer risk must be estimated from high dose exposure scenarios. However, there is increasing evidence that low and high dose exposures result in different signaling events and may have different mechanisms of cancer induction. We have examined the radiation induced temporal response of an in vitro three dimensional (3D) human skin tissue model using microarray-based transcriptional profiling. Our data shows that exposure to 100 mGy of X-rays is sufficient to affect gene transcription. Cell type specific analysis showed significant changes in gene expression with the levels of > 1400 genes altered in the dermis and > 400 genes regulated in the epidermis. The two cell types rarely exhibited overlapping responses at the mRNA level. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) measurements validated the microarray data in both regulation direction and value. Key pathways identified relate to cell cycle regulation, immune responses, hypoxia, reactive oxygen signaling, and DNA damage repair. We discuss in particular the role of proliferation and emphasizing how the disregulation of cellular signaling in normal tissue may impact progression towards radiation induced secondary diseases.

Freiin von Neubeck, Claere H.; Shankaran, Harish; Karin, Norman J.; Kauer, Paula M.; Chrisler, William B.; Wang, Xihai; Robinson, Robert J.; Waters, Katrina M.; Tilton, Susan C.; Sowa, Marianne B.

2012-04-17T23:59:59.000Z

18

Low Dose Radiation Program: Radiation Biology and the Radiation Research  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology and the Radiation Research Program Biology and the Radiation Research Program The Department of Energy (DOE) and its predecessor organizations, Energy Research and Development Agency (ERDA) and Atomic Energy Commission (AEC), always have been concerned about the health effects of ionizing radiation. Extensive research has been conducted under their sponsorship at all levels of biological organization from molecules to man. Over the past 60 years, studies using every type of radiation source have included exposure to both external radiation sources and to internally deposited radioactive materials. These exposures used different dose patterns and distributions delivered over a wide range of experimental times. This extensive research provided the basis for the new Low Dose Radiation Research Program, linking

19

Low-Dose Radiation Cataract and Genetic Determinants of Radiosensitivi...  

NLE Websites -- All DOE Office Websites (Extended Search)

Our research utilizes radiation cataract as a model system to study the effects of low-dose ionizing radiation exposure in a complex, highly differentiated tissue. We believe...

20

Radiation Leukaemongenesis at Low Doses  

NLE Websites -- All DOE Office Websites (Extended Search)

Leukaemongenesis at Low Doses Leukaemongenesis at Low Doses Simon Bouffler Health Protection Agency Abstract Myeloid leukaemias feature prominently among the cancers associated with human exposures to ionising radiation. The CBA mouse model of radiation-induced acute myeloid leukaemia (AML) has been used extensively for both quantitative and mechanistic studies. Loss of genetic material from chromosome 2 (chr2) is known to be associated with most radiation-induced AMLs. AML develops in CBA mice exposed to X- or γ-radiation, after a mean latency period of 18 months, with a maximal incidence of approximately 25% at 3Gy. A strong candidate AML-suppressor gene located within the commonly deleted region of chr2 has been identified, Sƒpil/PU.1. This gene suffers hemizygous loss and specific

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Low Dose Radiation Research Program: About  

NLE Websites -- All DOE Office Websites (Extended Search)

About About Background. Extensive research on the health effects of radiation using standard epidemiological and toxicological approaches has been done for decades to characterize responses of populations and individuals to high radiation doses, and to set exposure standards to protect both the public and the workforce. These standards were set using models that extrapolated from the cancers observed following exposure to high doses of radiation to predicted, but not measurable, changes in cancer frequency at low radiation doses. The use of models was necessary because of our inability to detect changes in cancer incidence following low doses of radiation. Historically, the predominant approach has been the Linear-no-Threshold model (see Wikipedia entry) and collective dose concept that assumes each unit of radiation, no

22

ORISE: DOE's Radiation Exposure Monitoring System (REMS)  

NLE Websites -- All DOE Office Websites (Extended Search)

Monitoring System (REMS) Monitoring System (REMS) ORISE maintains large database of radition exposure records for the U.S. Department of Energy ORISE staff monitoring radiation data for DOE Rule 10 CFR 835 establishes the U.S. Department of Energy's (DOE) occupational protection rule and requires assessment and recording of radiation doses to individuals who are exposed to sources of radiation or contamination. The Radiation Exposure Monitoring System (REMS) database is the radiation exposure data repository for all monitored DOE employees, contractors, subcontractors and members of the public. REMS maintains dose records for all monitored individuals dating back to 1969. Aggregated, site-specific data are available on the Radiation Exposure Monitoring System website for all years since 1986. Currently,

23

Sources Of Average Individual Radiation Exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

Of Average Individual Radiation Exposure Of Average Individual Radiation Exposure Natural background Medical Consumer products Industrial, security, educational and research Occupational 0.311 rem 0.300 rem 0.013 rem 0.0003 rem 0.0005 rem Savannah River Nuclear Solutions, LLC, provides radiological protection services and oversight at the Savannah River Site (SRS). These services include radiation dose measurements for persons who enter areas where they may be exposed to radiation or radioactive material. The results are periodically reported to monitored individuals. The results listed are based on a radiation dose system developed by the International Commission on Radiation Protection. The system uses the terms "effective dose," "equivalent dose" and units of rem. You may be more familiar with the term "millirem" (mrem), which is 1/1000 of a rem.

24

Radiation Risk from Chronic Low Dose-Rate Radiation Exposures: The Role of Life-Time Animal Studies - Workshop October 2005  

SciTech Connect

As a part of Radiation research conference, a workshop was held on life-long exposure studies conducted in the course of irradiation experiements done at Argonne National Laboratory between 1952-1992. A recent review article documents many of the issues discussed at that workshop.

Gayle Woloschak

2009-12-16T23:59:59.000Z

25

Radiation Leukemogenesis at Low Dose Rates  

SciTech Connect

The major goals of this program were to study the efficacy of low dose rate radiation exposures for the induction of acute myeloid leukemia (AML) and to characterize the leukemias that are caused by radiation exposures at low dose rate. An irradiator facility was designed and constructed that allows large numbers of mice to be irradiated at low dose rates for protracted periods (up to their life span). To the best of our knowledge this facility is unique in the US and it was subsequently used to study radioprotectors being developed for radiological defense (PLoS One. 7(3), e33044, 2012) and is currently being used to study the role of genetic background in susceptibility to radiation-induced lung cancer. One result of the irradiation was expected; low dose rate exposures are ineffective in inducing AML. However, another result was completely unexpected; the irradiated mice had a very high incidence of hepatocellular carcinoma (HCC), approximately 50%. It was unexpected because acute exposures are ineffective in increasing HCC incidence above background. This is a potential important finding for setting exposure limits because it supports the concept of an ?inverse dose rate effect? for some tumor types. That is, for the development of some tumor types low dose rate exposures carry greater risks than acute exposures.

Weil, Michael; Ullrich, Robert

2013-09-25T23:59:59.000Z

26

Chronic Low Dose Radiation Effects on Radiation Sensitivity  

NLE Websites -- All DOE Office Websites (Extended Search)

Chronic Low Dose Radiation Effects on Radiation Sensitivity Chronic Low Dose Radiation Effects on Radiation Sensitivity and Chromosome Instability Induction in TK6 Cells Schwartz J.L. 1 , Jordan R. 1 , Slovic J. 1 , Moruzzi A. 1 , Kimmel R. 2 , and Liber, H.L. 3 1 University of Washington, Seattle, WA; 2 Fred Hutchinson Cancer Research Center, Seattle, WA; 3 Colorado State University, Fort Collins, Colorado There are a number of cell responses that can be detected after low dose radiation exposures including the adaptive response, low dose hypersensitivity, and induced genomic instability. The relationship between these different phenomena is unknown. In this study, we measured adaptive responses, low dose hypersensitivity, and induced genomic instability in a human B-lymphoblastoid cell model, TK6, where we could genetically modify radiation responses by either over-expression of BCL-2 or deletion of TP53. TK6

27

DOE 2012 Occupational Radiation Exposure October 2013  

SciTech Connect

The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2012 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. Over the past 5-year period, the occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site. As an indicator of the overall amount of radiation dose received during the conduct of operations at DOE, the report includes information on collective total effective dose (TED). The TED is comprised of the effective dose (ED) from external sources, which includes neutron and photon radiation, and the internal committed effective dose (CED), which results from the intake of radioactive material into the body. The collective ED from photon exposure decreased by 23% between 2011 and 2012, while the neutron dose increased by 5%. The internal dose components of the collective TED decreased by 7%. Over the past 5-year period, 99.99% of the individuals receiving measurable TED have received doses below the 2 roentgen equivalent in man (rems) (20 millisievert [mSv]) TED administrative control level (ACL), which is well below the DOE regulatory limit of 5 rems (50 mSv) TED annually. The occupational radiation exposure records show that in 2012, DOE facilities continued to comply with DOE dose limits and ACLs and worked to minimize exposure to individuals. The DOE collective TED decreased 17.1% from 2011 to 2012. The collective TED decreased at three of the five sites with the largest collective TED. u Idaho Site Collective dose reductions were achieved as a result of continuing improvements at the Advanced Mixed Waste Treatment Project (AMWTP) through the planning of drum movements that reduced the number of times a container is handled; placement of waste containers that created highradiation areas in a centralized location; and increased worker awareness of high-dose rate areas. In addition, Idaho had the largest decrease in the total number of workers with measurable TED (1,143 fewer workers). u Hanford Site (Hanford) An overall reduction of decontamination and decommissioning (D&D) activities at the Plutonium Finishing Plant (PFP) and Transuranic (TRU) retrieval activities resulted in collective dose reductions. u Savannah River Site (SRS) Reductions were achieved through ALARA initiatives employed site wide. The Solid Waste Management Facility used extended specialty tools, cameras and lead shield walls to facilitate removal of drums. These tools and techniques reduce exposure time through improved efficiency, increase distance from the source of radiation by remote monitoring, shield the workers to lower the dose rate, and reduce the potential for contamination and release of material through repacking of waste. Overall, from 2011 to 2012, there was a 19% decrease in the number of workers with measurable dose. Furthermore, due to a slight decrease in both the DOE workforce (7%) and monitored workers (10%), the ratio of workers with measurable doses to monitored workers decreased to 13%. Another primary indicator of the level of radiation exposure covered in this report is the average measurable dose, which normalizes the collective dose over the population of workers who actually received a measurable dose. The average measurable TED in

none,

2012-02-02T23:59:59.000Z

28

Oxidative Stress and Skeletal Health with Low Dose, Ionizing Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Oxidative Stress and Skeletal Health with Low Dose, Ionizing Radiation Oxidative Stress and Skeletal Health with Low Dose, Ionizing Radiation Globus Ruth NASA Ames Research Center Abstract Osteoporosis profoundly affects the aging U.S. population and exposure to high doses of radiation causes bone loss similar to age-related osteoporosis, although the influence of low dose radiation exposures is not known. The central hypothesis of our DOE project (NASA supplement) is that low doses of radiation modulate subsequent skeletal degeneration via oxidative pathways. Our working hypothesis is that a prior exposure to low dose radiation regulates oxidative metabolism within bone and contributes to bone loss caused either by subsequent high, challenge doses of radiation or by aging. HZE source: Because astronauts are exposed to radiation from GCR and solar

29

Low Dose Radiation Research Program: Slide Shows  

NLE Websites -- All DOE Office Websites (Extended Search)

Dose Health Effects of Radiation Health Effects of Radiation Adaptive Response to Low Dose Radiation PDF Background Radiation PDF Bystander Effects PDF Dirty Bombs PDF DNA Damage...

30

Low Dose Radiation Research Program: Low Dose Radiation Research...  

NLE Websites -- All DOE Office Websites (Extended Search)

Low Dose Radiation Research: Outreach and Resources Authors: Antone L. Brooks and Lezlie A. Couch Institution: Washington State University Tri-Cities, Richland, Washington The...

31

Low Dose Radiation Research Program: Linking Molecular Events to Cellular  

NLE Websites -- All DOE Office Websites (Extended Search)

Linking Molecular Events to Cellular Responses at Low Dose Exposures Linking Molecular Events to Cellular Responses at Low Dose Exposures Thomas Weber Pacific Northwest National Laboratory Why This Project It currently costs billions of dollars to protect workers and the public from exposure to man-made radiation, despite exposure levels lower than the natural background levels of radiation. If it could be demonstrated that there is no increased cancer risk associated with these low dose exposures, these resources could be directed toward more critical societal issues. Defining low dose radiation cancer risks is limited by our ability to measure and directly correlate relevant cellular and molecular responses occurring at the low radiation dose and dose rate with tumor formation. This deficiency has led to conservative risk assessments based on low dose

32

DOE occupational radiation exposure 1996 report  

SciTech Connect

The goal of the US Department of Energy (DOE) is to conduct its radiological operations to ensure the health and safety of all DOE employees including contractors and subcontractors. The DOE strives to maintain radiation exposures to its workers below administrative control levels and DOE limits and to further reduce these exposures and releases to levels that are ``As Low As Reasonably Achievable`` (ALARA). The DOE Occupational Radiation Exposure Report, 1996 provides summary and analysis of the occupational radiation exposure received by individuals associated with DOE activities. The DOE mission includes stewardship of the nuclear weapons stockpile and the associated facilities, environmental restoration of DOE and precursor agency sites, and energy research. Collective exposure at DOE has declined by 80% over the past decade due to a cessation in opportunities for exposure during the transition in DOE mission from weapons production to cleanup, deactivation and decommissioning, and changes in reporting requirements and dose calculation methodology. In 1996, the collective dose decreased by 10% from the 1995 value due to decreased doses at five of the seven highest-dose DOE sites. For 1996, these sites attributed the reduction in collective dose to the completion of several decontamination and decommissioning projects, reduced spent fuel storage activities, and effective ALARA practices. This report is intended to be a valuable tool for managers in their management of radiological safety programs and commitment of resources.

NONE

1996-12-31T23:59:59.000Z

33

Genome Wide Evaluation of Normal Human Tissue in Response to Controlled, In vivo Low-Dose Low LET Ionizing Radiation Exposure: Pathways and Mechanisms Final Report, September 2013  

SciTech Connect

During course of this project, we have worked in several areas relevant to low-dose ionizing radiation. Using gene expression to measure biological response, we have examined the response of human skin exposed in-vivo to radation, human skin exposed ex-vivo to radiation, and a human-skin model exposed to radiation. We have learned a great deal about the biological response of human skin to low-dose ionizing radiation.

Rocke, David M. [University of California Davis

2013-09-09T23:59:59.000Z

34

Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with lung cancer mortality in the atomic bomb survivors study  

Science Conference Proceedings (OSTI)

Current lung cancer risk estimates after exposure to low-linear energy transfer radiation such as X rays are based on studies of people exposed to such radiation at high dose rates, for example the atomic bomb survivors. Radiobiology and animal experiments suggest that risks from exposure at low to moderate dose rates, for example medical diagnostic procedures, may be overestimated by such risk models, but data for humans to examine this issue are limited. In this paper we report on lung cancer mortality between 1950 and 1987 in a cohort of 64,172 Canadian tuberculosis patients, of whom 39% were exposed to highly fractionated multiple chest fluoroscopies leading to a mean lung radiation dose of 1.02 Sv received at moderate dose rates. These data have been used to estimate the excess relative risk per sievert of lung cancer mortality, and this is compared directly to estimates derived from 75,991 atomic bomb survivors. Based on 1,178 lung cancer deaths in the fluoroscopy study, there was no evidence of any positive association between risk and dose, with the relative risk at 1 Sv being 1.00 (95% confidence interval 0.94, 1.07), which contrasts with that based on the atomic bomb survivors, 1.60 (1.27, 1.99). The difference in effect between the two studies almost certainly did not arise by chance (P = 0.0001). This study provides strong support from data for humans for a substantial fractionation/dose-rate effect for low-linear energy transfer radiation and lung cancer risk. This implies that lung cancer risk from exposures to such radiation at present-day dose rates is likely to be lower than would be predicted by current radiation risk models based on studies of high-dose-rate exposures. 25 refs., 8 tabs.

Howe, G.R. [Univ. of Toronto, Ontario (Canada)

1995-06-01T23:59:59.000Z

35

Types of Radiation Exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

External Irradiation Contamination Incorporation Biological Effects of Acute, Total Body Irradiation Managing Radiation Emergencies Procedure Demonstration Types of radiation...

36

Low Dose Radiation Research Program: Genetic Factors Affecting  

NLE Websites -- All DOE Office Websites (Extended Search)

Affecting Susceptibility to Low-Dose Radiation Affecting Susceptibility to Low-Dose Radiation William F. Morgan Pacific Northwest National Laboratory Why This Project The short-term effects of high doses of ionizing radiation on cellular responses are relatively well understood. Less clear are the long-term consequences of exposure to low dose/low dose-rate radiation and the effects of radiation exposure on the progeny of surviving cells. If a cell survives radiation, it is generally thought to have repaired all the radiation-induced insults and be capable of a "normal healthy life". At a certain frequency, however, we have found that some cells surviving radiation grow normally, but will rearrange their genetic material during time in culture. We call this radiation-induced genomic instability. Many

37

Low Dose Radiation Program: Links - General Radiation Information  

NLE Websites -- All DOE Office Websites (Extended Search)

General Radiation Information Answers to Questions about Radiation Dose Ranges Charts - tables showing radiation dose ranges from radio diagnostics to cancer radiotherapy....

38

Low Dose Radiation Program: 2010 Low Dose Radiation Research Program  

NLE Websites -- All DOE Office Websites (Extended Search)

Low Dose Radiation Research Program Investigators' Workshop Low Dose Radiation Research Program Investigators' Workshop »» Event Slide Show More than 150 people attended this year's workshop, held April 12-14 at the Renaissance M Street Hotel in Washington, D.C. In addition to 34 plenary talks and more than 70 poster presentations made by the program investigators, participants heard guest speakers from the National Cancer Institute and from sister low-dose programs in Europe and Japan. Remarks from DOE Dr. Anna Palmisano, Associate Director, Office of Science, Director for Biological and Environmental Research (BER), welcomed the meeting participants, thanked Low Dose Radiation Research Program Manager Dr. Noelle Metting for her leadership, and acknowledged the importance of the Low Dose Program to DOE because of its unique focus and important role. She

39

Low Dose Radiation Research Program: Research Program Workshop I Abstracts  

NLE Websites -- All DOE Office Websites (Extended Search)

Genetic Factors Affecting Susceptibility to Low-Dose Radiation Genetic Factors Affecting Susceptibility to Low-Dose Radiation William F. Morgan and John H.J. Petrini Radiation Oncology Research Laboratory, University of Maryland at Baltimore, Baltimore, MD Summary: The goal of our application is to improve the scientific basis for understanding potential risks to the population from low dose radiation exposure based on potential genetic differences that may modulate an individual's sensitivity to low doses of radiation. Abstract: The goal of this application is to improve the scientific basis for understanding potential risks to the population from low dose radiation exposure. We propose to address specific genetic factors that affect individual susceptibility to low dose radiation and ask the question do genetic differences exist that make some individuals more sensitive to

40

Low Dose Radiation Program: Links - Online Literature  

NLE Websites -- All DOE Office Websites (Extended Search)

Online Literature Online Literature Journals, Books and other Publications Armed Forces Radiobiology Research Institute Chornobyl Center for Nuclear Safety Radioactive Waste and Radioecology "Insight" Magazine Central Research Institute of the Electric Power Industry (CRIEPI) News: Aiming at an information center on low dose radiation research Health Physics International Journal of Radiation Biology Iranian Journal of Radiation Research Journal of Radiological Protection National Council on Radiation Protection and Measurements Radiation Research U.S. Department of Energy (DOE) Information Bridge Reports Animal Cancer Tests and Human Cancer Risk Assessment: A Broad Perspective Effects of Ionizing Radiation: Atomic Bomb Survivors and Their Children (1945-1995) Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

SCIENTIFIC CORRESPONDENCE Radiation doses  

E-Print Network (OSTI)

-- ation doses and cancer rates to the workers m the first Soviet atom-bomb facility, near 2 Chelyabinsk-dose groups. Unfortunately, they did not report the number in the workforce. Pending release of the full data' Forschungsergebmsse All (1972). 2.Hunter J. R.. Unesco Reports m Marine Soence 28, (1984). 3. Hassan. E. M. & Hassan

Shlyakhter, Ilya

42

Epidemiology of accidental radiation exposures  

Science Conference Proceedings (OSTI)

Much of the information on the health effects of radiation exposure available to date comes from long-term studies of the atomic bombings in Hiroshima and Nagasaki. Accidental exposures, such as those resulting from the Chernobyl and Kyshtym accidents, have as yet provided little information concerning health effects of ionizing radiation. This paper will present the current state of our knowledge concerning radiation effects, review major large-scale accidental exposures and the types of studies that are needed. 64 refs., 3 tabs.

Cardis, E. [International Agency for Research on Cancer, Lyon (France)

1996-05-01T23:59:59.000Z

43

DOE occupational radiation exposure. Report 1992--1994  

Science Conference Proceedings (OSTI)

The DOE Occupational Radiation Exposure Report, 1992-1994 reports occupational radiation exposures incurred by individuals at US Department of Energy (DOE) facilities from 1992 through 1994. This report includes occupational radiation exposure information for all DOE employees, contractors, subcontractors, and visitors. This information is analyzed and trended over time to provide a measure of the DOE`s performance in protecting its workers from radiation. Occupational radiation exposure at DOE has been decreasing over the past 5 years. In particular, doses in the higher dose ranges are decreasing, including the number of doses in excess of the DOE limits and doses in excess of the 2 rem Administrative Control Level (ACL). This is an indication of greater attention being given to protecting these individuals from radiation in the workplace.

NONE

1997-05-01T23:59:59.000Z

44

Low Dose Radiation Research Program: DOE / NASA Joint Funded Projects  

NLE Websites -- All DOE Office Websites (Extended Search)

DOE/NASA Joint Funded Projects DOE/NASA Joint Funded Projects NASA Source Photo Space explorers are subject to exposure to low dose ionizing radiation. Research that helps determine health risks from this exposure is funded by NASA and DOE. Source: NASA DOE's Low Dose Program and the National Aeronautics and Space Administration (NASA) jointly fund new research to develop a better scientific basis for understanding risks to humans from exposures to low doses or low fluences of ionizing radiation. Research must focus on elucidating molecular mechanisms and pathways involved in normal radiobiological responses to low dose exposure, and must have the potential to ultimately increase understanding of health outcomes from radiation exposures that are at or near current workplace exposure

45

Radiation dose estimates for radiopharmaceuticals  

SciTech Connect

Tables of radiation dose estimates based on the Cristy-Eckerman adult male phantom are provided for a number of radiopharmaceuticals commonly used in nuclear medicine. Radiation dose estimates are listed for all major source organs, and several other organs of interest. The dose estimates were calculated using the MIRD Technique as implemented in the MIRDOSE3 computer code, developed by the Oak Ridge Institute for Science and Education, Radiation Internal Dose Information Center. In this code, residence times for source organs are used with decay data from the MIRD Radionuclide Data and Decay Schemes to produce estimates of radiation dose to organs of standardized phantoms representing individuals of different ages. The adult male phantom of the Cristy-Eckerman phantom series is different from the MIRD 5, or Reference Man phantom in several aspects, the most important of which is the difference in the masses and absorbed fractions for the active (red) marrow. The absorbed fractions for flow energy photons striking the marrow are also different. Other minor differences exist, but are not likely to significantly affect dose estimates calculated with the two phantoms. Assumptions which support each of the dose estimates appears at the bottom of the table of estimates for a given radiopharmaceutical. In most cases, the model kinetics or organ residence times are explicitly given. The results presented here can easily be extended to include other radiopharmaceuticals or phantoms.

Stabin, M.G.; Stubbs, J.B.; Toohey, R.E. [Oak Ridge Inst. of Science and Education, TN (United States). Radiation Internal Dose Information Center

1996-04-01T23:59:59.000Z

46

Health Risks Associated with Low Doses of Radiation  

Science Conference Proceedings (OSTI)

Despite a wealth of information, there remains uncertainty concerning human radiation effects at low dose levels. This report provides background information and a literature review of research on the potential health hazards associated with exposure to low-level ionizing radiation. Topics include radiation characteristics, protection standards, epidemiologic data and risk models, the nature of human health exposure-related effects, important radiation health studies to date, and the scientific method fo...

1994-09-17T23:59:59.000Z

47

Low Dose Radiation Research Program: DOE Lowdose Radiation Program Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Using a Low LET Electron Microbeam to Investigate Non-Targeted Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation. Authors: William F. Morgan1 and Marianne B. Sowa2 Institutions: 1Radiation Oncology Research Laboratory, University of Maryland, Baltimore MD 21201 2 Chemical Structure and Dynamics, Pacific Northwest National Laboratory, Richland WA 99352 We have recently installed a low LET electron microbeam that generates energetic electrons to mimic radiation damage from gamma and x-ray sources. It has been designed such that high-energy electrons deposit energy in a pre-selected subset of cells leaving neighboring cells unirradiated (Figure 1). In this way it is possible to examine non-targeted effects associated with low dose radiation exposure including induced genomic instability and

48

Low Dose Radiation Research Program: Mechanisms of Tissue Response...  

NLE Websites -- All DOE Office Websites (Extended Search)

whole body exposure to doses of 0.1 Gy to 5 Gy 60Co-g radiation in liver and mammary gland, which indicate that remodeling is a general and rapid consequence of irradiation but...

49

Low Dose Radiation Research Program: Suresh H. Moolgavkar  

NLE Websites -- All DOE Office Websites (Extended Search)

cohort with low-LET low-dose radiation exposure, and comparison with Japanese atomic bomb survivors. Hazelton, W.D., Krewski, D., Moolgavkar, S.H. 2001 Workshop:...

50

Low Dose Radiation Research Program: James D. Tucker  

NLE Websites -- All DOE Office Websites (Extended Search)

Role of the Adaptive Response in determining health risks from in vivo exposures to low dose of ionizing radiation Tucker, J. Publications Christian, A.T., Patte, M.S., Attix,...

51

Low Dose Radiation Research Program: Low-Dose Dose-Response of  

NLE Websites -- All DOE Office Websites (Extended Search)

Low-Dose Dose-Response of Proliferating Human Cells Exposed to Low Low-Dose Dose-Response of Proliferating Human Cells Exposed to Low Dose Rate g-Radiation. Authors: Louise Enns,1 Michael Weinfeld,1 Albert Murtha,1 and Kenneth Bogen2 Institutions: 1Cross Cancer Institute and 2Lawrence Livermore National Laboratory. Clinical and environmental exposure to ionizing radiation rarely exceeds 200 cGy. To examine cell proliferation at early times (up to 5 days) post-irradiation, we are utilizing an assay in which single cells encapsulated within ~30- to 70-µm-diameter agarose gel microdrops (GMDs) are exposed and cultured for 4 days at 37°C, then analyzed by flow cytometry (FC). Clonogenic proliferation is measured as the fraction of occupied GMDs containing multicellular microcolonies after 4 days in culture. This assay was applied to human A549 lung cells exposed to gamma

52

DOE Radiation Exposure Monitoring System (REMS) Data Update  

SciTech Connect

This slide show presents the 2011 draft data for DOE occupational radiation exposure.Clarification is given on Reporting Data regarding: reporting Total Organ Dose (TOD); reporting Total Skin Dose (TSD), and Total Extremity Dose (TExD) ; and Special individuals reporting.

Rao, Nimi; Hagemeyer, Derek

2012-05-05T23:59:59.000Z

53

Low Dose Radiation Research Program: Low Dose Radiation Effects in  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Effects in Differentiating Human Lens Cells Radiation Effects in Differentiating Human Lens Cells E.A. Blakely1, M.P. McNamara1, P.Y. Chang1, K.A. Bjornstad1, D. Sudar1, and A.C. Thompson2 1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California; 2Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, California. Introduction The human lens is one of the most radiosensitive organs of the body. Cataract, the opacification of the lens, is a late-appearing response to radiation damage. There are few data available on the late radiation effects of exposure in space flight to charged particle beams, the most prevalent of which are protons. Basic research in this area is needed to integrate the responses of both critical and other representative tissues

54

Effects of prenatal exposure to ionizing radiation  

SciTech Connect

Prenatal exposure to ionizing radiation induces some effects that are seen at birth and others that cannot be detected until later in life. Data from A-bomb survivors in Hiroshima and Nagasaki show a diminished number of births after exposure under 4 wk of gestational age. Although a wide array of congenital malformations has been found in animal experimentation after such exposure to x rays, in humans only small head size (exposure at 4-17 wk) and mental retardation (exposure primarily at 8-15 wk) have been observed. In Hiroshima, small head size occurred after doses of 0.10-0.19 Gy or more, and an excess of mental retardation at 0.2-0.4 Gy or more. Intelligence test scores were reduced among A-bomb survivors exposed at 8-15 wk of gestational age by 21-29 IQ points per Gy. Other effects of in-utero exposure to atomic radiation include long-lasting complex chromosome abnormalities.

Miller, R.W. (National Cancer Institute, Bethesda, MD (USA))

1990-07-01T23:59:59.000Z

55

Low Dose Radiation Program: Selected Websites  

NLE Websites -- All DOE Office Websites (Extended Search)

The views expressed in these links do not necessarily reflect the view of the Low Dose Radiation Research Program. Scientific Links Agencies with Radiation Regulatory...

56

Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low Dose, Low Dose Rate Exposures  

SciTech Connect

OAK - B135 This project final report summarizes modeling research conducted in the U.S. Department of Energy (DOE), Low Dose Radiation Research Program at the Lovelace Respiratory Research Institute from October 1998 through June 2003. The modeling research described involves critically evaluating the validity of the linear nonthreshold (LNT) risk model as it relates to stochastic effects induced in cells by low doses of ionizing radiation and genotoxic chemicals. The LNT model plays a central role in low-dose risk assessment for humans. With the LNT model, any radiation (or genotoxic chemical) exposure is assumed to increase ones risk of cancer. Based on the LNT model, others have predicted tens of thousands of cancer deaths related to environmental exposure to radioactive material from nuclear accidents (e.g., Chernobyl) and fallout from nuclear weapons testing. Our research has focused on developing biologically based models that explain the shape of dose-response curves for low-dose radiation and genotoxic chemical-induced stochastic effects in cells. Understanding the shape of the dose-response curve for radiation and genotoxic chemical-induced stochastic effects in cells helps to better understand the shape of the dose-response curve for cancer induction in humans. We have used a modeling approach that facilitated model revisions over time, allowing for timely incorporation of new knowledge gained related to the biological basis for low-dose-induced stochastic effects in cells. Both deleterious (e.g., genomic instability, mutations, and neoplastic transformation) and protective (e.g., DNA repair and apoptosis) effects have been included in our modeling. Our most advanced model, NEOTRANS2, involves differing levels of genomic instability. Persistent genomic instability is presumed to be associated with nonspecific, nonlethal mutations and to increase both the risk for neoplastic transformation and for cancer occurrence. Our research results, based on applications of NEOTRANS2, indicate that nonlinear threshold-type, dose-response relationships for excess stochastic effects (problematic nonlethal mutations, neoplastic transformation) should be expected after exposure to low linear energy transfer (LET) gamma rays or gamma rays in combination with high-LET alpha radiation. Similar thresholds are expected for low-dose-rate low-LET beta irradiation. We attribute the thresholds to low-dose, low-LET radiation induced protection against spontaneous mutations and neoplastic transformations. The protection is presumed mainly to involve selective elimination of problematic cells via apoptosis. Low-dose, low-LET radiation is presumed to trigger wide-area cell signaling, which in turn leads to problematic bystander cells (e.g., mutants, neoplastically transformed cells) selectively undergoing apoptosis. Thus, this protective bystander effect leads to selective elimination of problematic cells (a tissue cleansing process in vivo). However, this protective bystander effects is a different process from low-dose stimulation of the immune system. Low-dose, low-LET radiation stimulation of the immune system may explain why thresholds for inducing excess cancer appear much larger (possibly more than 100-fold larger) than thresholds for inducing excess mutations and neoplastic transformations, when the dose rate is low. For ionizing radiation, the current risk assessment paradigm is such that the relative risk (RR) is always 1, no matter how small the dose. Our research results indicate that for low-dose or low-dose-rate, low-LET irradiation, RR < 1 may be more the rule than the exception. Directly tied to the current RR paradigm are the billion-dollar cleanup costs for radionuclide-contaminated DOE sites. Our research results suggest that continued use of the current RR paradigm for which RR 1 could cause more harm than benefit to society (e.g., by spreading unwarranted fear about phantom excess risks associated with low-dose low-LET radiation). Such phantom risks also may arise from risk assessments conducted for com

Scott, Bobby, R., Ph.D.

2003-06-27T23:59:59.000Z

57

Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low Dose, Low Dose Rate Exposures  

Science Conference Proceedings (OSTI)

OAK - B135 This project final report summarizes modeling research conducted in the U.S. Department of Energy (DOE), Low Dose Radiation Research Program at the Lovelace Respiratory Research Institute from October 1998 through June 2003. The modeling research described involves critically evaluating the validity of the linear nonthreshold (LNT) risk model as it relates to stochastic effects induced in cells by low doses of ionizing radiation and genotoxic chemicals. The LNT model plays a central role in low-dose risk assessment for humans. With the LNT model, any radiation (or genotoxic chemical) exposure is assumed to increase ones risk of cancer. Based on the LNT model, others have predicted tens of thousands of cancer deaths related to environmental exposure to radioactive material from nuclear accidents (e.g., Chernobyl) and fallout from nuclear weapons testing. Our research has focused on developing biologically based models that explain the shape of dose-response curves for low-dose radiation and genotoxic chemical-induced stochastic effects in cells. Understanding the shape of the dose-response curve for radiation and genotoxic chemical-induced stochastic effects in cells helps to better understand the shape of the dose-response curve for cancer induction in humans. We have used a modeling approach that facilitated model revisions over time, allowing for timely incorporation of new knowledge gained related to the biological basis for low-dose-induced stochastic effects in cells. Both deleterious (e.g., genomic instability, mutations, and neoplastic transformation) and protective (e.g., DNA repair and apoptosis) effects have been included in our modeling. Our most advanced model, NEOTRANS2, involves differing levels of genomic instability. Persistent genomic instability is presumed to be associated with nonspecific, nonlethal mutations and to increase both the risk for neoplastic transformation and for cancer occurrence. Our research results, based on applications of NEOTRANS2, indicate that nonlinear threshold-type, dose-response relationships for excess stochastic effects (problematic nonlethal mutations, neoplastic transformation) should be expected after exposure to low linear energy transfer (LET) gamma rays or gamma rays in combination with high-LET alpha radiation. Similar thresholds are expected for low-dose-rate low-LET beta irradiation. We attribute the thresholds to low-dose, low-LET radiation induced protection against spontaneous mutations and neoplastic transformations. The protection is presumed mainly to involve selective elimination of problematic cells via apoptosis. Low-dose, low-LET radiation is presumed to trigger wide-area cell signaling, which in turn leads to problematic bystander cells (e.g., mutants, neoplastically transformed cells) selectively undergoing apoptosis. Thus, this protective bystander effect leads to selective elimination of problematic cells (a tissue cleansing process in vivo). However, this protective bystander effects is a different process from low-dose stimulation of the immune system. Low-dose, low-LET radiation stimulation of the immune system may explain why thresholds for inducing excess cancer appear much larger (possibly more than 100-fold larger) than thresholds for inducing excess mutations and neoplastic transformations, when the dose rate is low. For ionizing radiation, the current risk assessment paradigm is such that the relative risk (RR) is always 1, no matter how small the dose. Our research results indicate that for low-dose or low-dose-rate, low-LET irradiation, RR fear about phantom excess risks associated with low-dose low-LET radiation). Such phantom risks also may arise from risk assessments conducted for com

Scott, Bobby, R., Ph.D.

2003-06-27T23:59:59.000Z

58

Low Dose Radiation Research Program: Image Gallery  

NLE Websites -- All DOE Office Websites (Extended Search)

Image Gallery Image Gallery These are images, photographs, and charts presented or developed for Low Dose Radiation Research Investigators’ Meetings. They may be used for presentations or reports. To save, right click on the picture, then choose "Save picture as." U.S. annual per-capita effective radiation dose from various sources for 1980. various sources 1980 Enlarge Image. U.S. annual per-capita effective radiation dose from various sources for 2006. various sources 2006 Enlarge Image. U.S. annual per-capita effective radiation dose from man-made sources in the United States for 2006. man-made 2006 Enlarge Image. Ionizing Radiation Dose Ranges showing the wide range of radiation doses that humans experience (Rem) Enlarge Image. Ionizing Radiation Dose Ranges showing the wide range of radiation doses that humans experience

59

Low Dose Radiation Program: Links - Organizations Conducting Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Conducting Low Dose Radiation Research Conducting Low Dose Radiation Research DOE Low Dose Radiation Research Program DoReMi Integrating Low Dose Research High Level Expert Group (HLEG) on European Low Dose Risk Research Multidisciplinary European Low Dose Initiative (MELODI) RISC-RAD Radiosensitivity of Individuals and Susceptibility to Cancer induced by Ionizing Radiation United States Transuranium & Uranium Registries Organizations Conducting other Radiation Research Argonne National Laboratory (ANL) Armed Forces Radiology Research Institute (AFRRI) Atmospheric Radiation Measurement (ARM) Program Brookhaven National Laboratory (BNL) Center for Devices and Radiological Health (CDRH) Central Research Institute of Electric Power Industry (CRIEPI) Colorado State University Columbia University

60

IMPRINTED GENES & TRANSPOSITIONS: EPIGENOMIC TARGETS FOR LOW DOSE RADIATION EFFECTS  

Science Conference Proceedings (OSTI)

The overall hypothesis of this grant application is that low dose ionizing radiation (LDIR) elicits adaptive responses in part by causing heritable DNA methylation changes in the epigenome. This novel postulate was tested by determining if the level of DNA methylation at the Agouti viable yellow (A{sup vy}) metastable locus is altered, in a dose-dependent manner, by low dose radiation exposure (radiation hormesis, bringing into question the assumption that every dose of radiation is harmful. Our findings not only have significant implications concerning the mechanism of hormesis, but they also emphasize the potential importance of this phenomenon in determining human risk at low radiation doses. Since the epigenetic regulation of genes varies markedly between species, the effect of LDIR on other epigenetically labile genes (e.g. imprinted genes) in animals and humans needs to be defined.

Randy Jirtle

2012-10-11T23:59:59.000Z

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

DOE 2010 Occupational Radiation Exposure November 2011  

Science Conference Proceedings (OSTI)

This report discusses radiation protection and dose reporting requirements, presents the 2010 occupational radiation dose data trended over the past 5 years, and includes instructions to submit successful ALARA projects.

U.S. Department of Energy, Office of Health, Safety and Security, Office of Analysis

2011-11-11T23:59:59.000Z

62

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

Atomic Bomb by Radiation Dose, Years Research Research after Survivors, Hiroshima and Nagasaki, 1950-71 Exposure, Age,atomic bomb survivors in Hiroshima and Nagasaki (36), and the Japanese Here, 'here is an The latent age-

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

63

Low Dose Radiation Research Program: Do Heritable Differences in an  

NLE Websites -- All DOE Office Websites (Extended Search)

Do Heritable Differences in an Individual's Immune System Predict Do Heritable Differences in an Individual's Immune System Predict Differential Sensitivity to Low Dose Radiation Exposure? Quantitative trait loci (QTL) mapping Enlarge Image Quantitative trait loci (QTL) mapping identifies two strong candidate genes, Ptprk (Chr 10) and Acp1 (Chr 12) that are linked to genetic variation in the relative abundance of peripheral Th and Tc cells, two cell populations that are sensitive to radiation exposure at low doses. Expression of each gene is significantly altered by exposure to low dose radiation in vivo. Genome-wide scans for the ratio of %CD4+ (Th) to %CD8+ (Tc) lymphocytes were performed using genenetwork.org. The solid horizontal line represents genome-wide significance at P < 0.05, based on 1,000 permutations. LOD indicates logarithm of odds scores.

64

Radiation doses for Marshall Islands Atolls Affected by U.S. Nuclear Testing:All Exposure Pathways, Remedial Measures, and Environmental Loss of 137Cs  

SciTech Connect

The United States conducted 24 nuclear tests at Bikini Atoll with a total yield of 76.8 Megatons (MT). The Castle series produced about 60% of this total and included the Bravo test that was the primary source of contamination of Bikini Island and Rongelap and Utrok Atolls. One of three aerial drops missed the atoll and the second test of the Crossroads series, the Baker test, was an underwater detonation. Of the rest, 17 were on barges on water and 3 were on platforms on an island; they produced most of the contamination of islands at the atoll. There were 42 tests conducted at Enewetak Atoll with a total yield of 31.7 MT (Simon and Robison, 1997; UNSCEAR, 2000). Of these tests, 18 were on a barge over wateror reef, 7 were surface shots, 2 aerial drops, 2 under water detonations, and 13 tower shots on either land or reef. All produced some contamination of various atoll islands. Rongelap Atoll received radioactive fallout as a result of the Bravo test on March 1, 1954 that was part of the Castle series of tests. This deposition was the result of the Bravo test producing a yield of 15 MT, about a factor of three to four greater than the predicted yield that resulted in vaporization of more coral reef and island than expected and in the debris-cloud reaching a much higher altitude than anticipated. High-altitude winds were to the east at the time of detonation and carried the debris-cloud toward Rongelap Atoll. Utrok Atoll also received fallout from the Bravo test but at much lower air and ground-level concentrations than at Rongelap atoll. Other atolls received Bravo fallout at levels below that of Utrok [other common spellings of this island and atoll (Simon, et al., 2009)]. To avoid confusion in reading other literature, this atoll and island are spelled in a variety of ways (Utrik, Utirik, Uterik or Utrok). Dose assessments for Bikini Island at Bikini Atoll (Robison et al., 1997), Enjebi Island at Enewetak Atoll (Robison et al., 1987), Rongelap Island at Rongelap Atoll (Robison et al., 1994; Simon et al., 1997), and Utrok Island at Utrok Atoll (Robison, et al., 1999) indicate that about 95-99% of the total estimated dose to people who may return to live at the atolls today (Utrok Island is populated) is the result of exposure to {sup 137}Cs. External gamma exposure from {sup 137}Cs in the soil accounts for about 10 to 15% of the total dose and {sup 137}Cs ingested during consumption of local food crops such as drinking coconut meat and fluid (Cocos nucifera L.), copra meat and milk, Pandanus fruit, and breadfruit accounts for about 85 to 90%. The other 1 to 2% of the estimated dose is from {sup 90}Sr, {sup 239+240}Pu, and {sup 241}Am. The {sup 90}Sr exposure is primarily through the food chain while the exposure to {sup 239+240}Pu, and {sup 241}Am is primarily via the inhalation pathway as a result of breathing re-suspended soil particles.

Robison, W L; Hamilton, T F

2009-04-20T23:59:59.000Z

65

Molecular Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation Colette A. Sacksteder § , DJ Black ‡ , Heather Smallwood § , David G. Camp II † , and Thomas C. Squier § § Cell Biology and Biochemistry; † Biological Sciences Division Pacific Northwest National Laboratory, Richland WA 99352 ‡ School of Biological Sciences, University of Missouri, Kansas City MO 64110 The goal of this research is to identify the molecular mechanisms by which cells adapt to low dose radiation exposure. Previously we have shown a radiation dependent increase of Calmodulin (CaM) in RAW 264.7 macrophages (RAW). Therefore we hypothesize that CaM and associated signaling complexes are sensors of low-dose radiation, resulting in alterations in energy metabolism and gene expression. The ultimate experimental goal

66

Low Dose Radiation Research Program: Molecular Characterization of the  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Characterization of the Roles of SOD Genes in Mammalian Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Authors: Chuan-Yuan Li, Zhanjun Guo, Zhonghui Yang, and Eric Chuang Institutions: Dept of Radiation Oncology, Duke University Medical Center, Durham, NC Advanced Technology Center, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Background The potential risks of exposure to low dose radiation are of major concerns to the DOE/OBER Low Dose Radiation Research Program. It has been long recognized that much of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Therefore internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying

67

Low Dose Radiation Research Program: 2003 Molecular Characterization of the  

NLE Websites -- All DOE Office Websites (Extended Search)

Characterization of the Roles of SOD Genes in Mammalian Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Authors: Chuan-Yuan Li,1 Eric Chuang2 Institutions: 1Dept of Radiation Oncology, Duke University Medical Center, Durham, NC, 2Advanced Technology Center, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland The potential risks of exposure to low dose radiation are of major concerns to the DOE/OBER Low Dose Radiation Research Program. It has been long recognized that much of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Therefore, internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying

68

Low Dose Radiation Research Program Publications  

NLE Websites -- All DOE Office Websites (Extended Search)

for medical exposures. Environmental and Molecular Mutagenesis 53(4): 247259 Lynn Hlatky ( 2012) Double-Strand Break Motions Shift Radiation Risk Notions?. PNAS...

69

ORISE: Radiation Dose Estimates and Other Compendia  

NLE Websites -- All DOE Office Websites (Extended Search)

article addresses methods that can be used to rapidly estimate internal and external radiation dose magnitudes that can be used to help guide early medical management. Included...

70

Low Dose Radiation Research Program: Katherine Vallis  

NLE Websites -- All DOE Office Websites (Extended Search)

Margaret Hospital Newly Funded Project The Characterization of Genetic Responses to Low Dose Radiation Using a Genome-Wide Insertional Mutagensis Approach Technical Abstracts 2005...

71

Low Dose Radiation Research Program: Multidimensional Analysis...  

NLE Websites -- All DOE Office Websites (Extended Search)

Multidimensional Analysis of Human Epithelial Cell Response to Low Dose Radiation Mary Helen Barcellos-Hoff Lawrence Berkeley National Laboratory Berkeley, CA. (Jointly funded by...

72

Low Dose Radiation Research Program: Biologically Based Analysis of Lung  

NLE Websites -- All DOE Office Websites (Extended Search)

Biologically Based Analysis of Lung Cancer Incidence in a Large Biologically Based Analysis of Lung Cancer Incidence in a Large Canadian Occupational Cohort with Low-LET Low-dose Radiation Exposure, and Comparison with Japanese Atomic Bomb Survivors. Authors: W.D. Hazelton, D. Krewski, S.H. Moolgavkar Lung cancer incidence is analyzed in a large Canadian National Dose Registry (CNDR) cohort with individual annual dosimetry for low-dose occupational exposure to gamma and tritium radiation using several types of multistage models. The primary analysis utilizes the two-stage clonal expansion model (TSCE), with sensitivity analyses using extensions of this model incorporating additional stages. Characteristic and distinct temporal patterns of risk are found for dose-response affecting early, middle, or late stages of carcinogenesis, e.g., initiation with one or more stages,

73

Low Dose Radiation Research Program: Janet E. Baulch  

NLE Websites -- All DOE Office Websites (Extended Search)

Janet E. Baulch Janet E. Baulch University of California, Davis Currently Funded Projects Impact of Genetic Factors on the Heritable Effects of Paternal Exposure to Low-Dose Radiation Technical Abstracts 2003 Workshop: DNA damage in acutely irradiated F2 mice with a history of paternal F0 germline irradiation Baulch, J.E. and Raabe, O G. 2002 Workshop Impact of Genetic Factors on the Heritable Effects of Paternal Exposure to Low-Dose Radiation, Baulch, J.E., Ph.D. and Raabe, O.G., Ph.D. Publications Kovalchuk, O. and Baulch, J.E. (2008). Epigenetic changes and nontargeted radiation effects - Is there a link? Environmental and Molecular Mutagenesis 49(1):16-25 Laiakis, E.C., Baulch, J.E., and Morgan, W.F. (2008). Interleukin 8 exhibits a pro-mitogenic and pro-survival role in radiation induced

74

Low Dose Radiation Research Program: Radiation Response in Normal...  

NLE Websites -- All DOE Office Websites (Extended Search)

genes. Using rigorous computational methods, we characterized the dose-dependent, radiation-induced gene expression of HSF-42, a primary cell culture. Our preliminary results...

75

15TH INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT Alpha radiation exposure decreases apoptotic cells in zebrafish  

E-Print Network (OSTI)

15TH INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT Alpha radiation exposure decreases apoptotic of an adaptive response by the ionizing radiation against sub- sequent exposures to Cd. Keywords Multiple embryos subjected to a priming exposure provided by one environmental stressor (low-dose alpha particles

Yu, K.N.

76

Low Dose Radiation Research Program: Marianne B. Sowa  

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Marianne B. Sowa Marianne B. Sowa PNNL - Pacific Northwest National Laboratory Funded Projects A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells Technical Abstracts 2006 Workshop: Using a Low-LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation. Sowa, M.B., Goetz, W., Baulch, J., and Morgan, W.F. Morphological Changes in a 3D Mammary Model Following Exposure to Low Dose, Low-LET Radiation Opresko, L.K., Chrisler, W., Emory, K., Arthurs, B., and Sowa, M.B. 2005 Workshops: Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation Morgan, W.F. and Sowa, M.B. Publications Perrine, K.A., Lamarche, B.L., Hopkins, D.F., Budge, S.E., Opresko, L.K., Wiley, H.S., and Sowa, M.B. (2007). High speed method for in situ

77

Low Dose Radiation Research Program: Current Funded Project Descriptions  

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Funded Project Descriptions Funded Project Descriptions Effects Of Low Doses of Radiation on DNA Repair Jointly funded by NASA and DOE Eric J Ackerman Pacific Northwest National Laboratory Richland, WA 99352 Dr. Ackerman will study the effect of low doses of ionizing radiation on the repair of different types of damage to DNA, including damage from ionizing radiation and that produced by the normal internal operation of the cell. Using a very sensitive technique called host cell reactivation assay (HCR), he will quantitatively measure the repair of each type of DNA damage and thereby measure if the cellular repair system itself has been damaged. He will also determine if unique forms of DNA repair system damage are induced by low doses of cosmic radiation exposure present during space

78

Low Dose Radiation Research Program: Project Descriptions-Archive  

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Project Descriptions-Archive Project Descriptions-Archive Effects Of Low Doses of Radiation on DNA Repair Eric J Ackerman (former PNNL) (Jointly funded by NASA and DOE) Pacific Northwest National Laboratory Richland, WA Dr. Ackerman will study the effect of low doses of ionizing radiation on the repair of different types of damage to DNA, including damage from ionizing radiation and that produced by the normal internal operation of the cell. Using a very sensitive technique called host cell reactivation assay (HCR), he will quantitatively measure the repair of each type of DNA damage and thereby measure if the cellular repair system itself has been damaged. He will also determine if unique forms of DNA repair system damage are induced by low doses of cosmic radiation exposure present during space

79

Medical x-ray exposure doses as contaminants of atomic bomb doses  

SciTech Connect

Since 1967 at the times of their biennial ABCC/RERF radiological examinations, all Adult Health Study (AHS) subjects have been interviewed to determine the exposures to medical x-rays they experienced in institutions other than RERF in order to estimate the numbers of examinations and corresponding doses which they received. These data have been stored on computer tapes together with the doses these subjects received during their radiological examinations in the ABCC/RERF Department of Radiology. Thus, their medical x-ray doses are available along with their atomic bomb doses (tentative 1965 doses revised, T65DR) for assessment of the role of ionizing radiation in the development of diseases. The medical x-ray doses incurred at RERF were assessed by means of phantom dosimetry. Those at other institutions were determined using phantom dosimetry data and results of surveys for trends in radiological examinations in Hiroshima and Nagasaki. By the end of 1982, the average medical x-ray doses to the active bone marrow were 12.04 mGy for A-bomb exposed groups and 8.92 mGy for control groups (not-in-cities); to the male gonads, 2.26 mGy and 1.89 mGy, respectively; and to the female gonads, 17.45 mGy and 12.58 mGy, respectively. Results for Hiroshima and Nagasaki were similar. The main impact of medical x-ray doses was in the lowest T65DR group. Medical x-ray active bone marrow doses ranged from 0.05-500% (mean, 35%) of A-bomb doses in the 10-99 mGy T65DR group. In the 100-999 mGy T65DR group, medical x-ray active bone marrow doses ranged from 0.005-50% (mean, 5%) of their T65DR. In the greater than 1000-mGy T65DR group, medical x-ray exposures were proportionally less. Medical x-ray exposures produced smaller doses to the gonads of males than to those of the females.

Yamamoto, O.; Antoku, S.; Russell, W.J.; Fujita, S.; Sawada, S.

1988-03-01T23:59:59.000Z

80

Low Dose Radiation Research Program: Impact of Genetic Factors on the  

NLE Websites -- All DOE Office Websites (Extended Search)

Genetic Factors on the Heritable Effects of Paternal Exposure to Genetic Factors on the Heritable Effects of Paternal Exposure to Low-Dose Radiation Janet E. Baulch University of California, Davis Why This Project? There is concern about the possible genetic effects of low dose radiation exposure. As a result, much effort has gone towards understanding mutation of cells due to radiation exposure. While recognition of the potential for mutation from exposure to ionizing radiation has led to extensive research, less effort has been given to the possible delayed risk of radiation exposure transmitted to the offspring of the exposed parent. Data from animal models show that parental exposures to DNA-damaging agents, such as ionizing radiation, predispose the offspring to serious health effects, including cancer offspring. Additionally, data from both humans and animal

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81

Low Dose Radiation Research Program: Glossary  

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Glossary Glossary A B C D E F G H I J K L M N O P Q R S T U V W X Y Z We welcome updates to the glossary. Please send them to Low Dose. A α=β Ratio: A measure of the curvature of the cell survival curve and a measure of the sensitivity of a tissue or tumor to dose fractionation. The dose at which the linear and quadratic components of cell killing are equal. Abscopal Effect: The radiation response in tissue at a distance from the irradiated site invoked by local irradiation. Absorbed Dose Rate: Absorbed dose divided by the time it takes to deliver that dose. High dose rates are usually more damaging to humans and animals than low-dose rates. This is because repair of damage is more efficient when the dose rate is low. Absorbed Dose: The amount of energy deposited in any substance by ionizing

82

Low Dose Radiation Program: Workshop VI Abstracts  

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Workshop VI Principal Investigator and Abstracts Workshop VI Principal Investigator and Abstracts Anderson, Carl Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Application to p53 and Low Dose Ionizing Radiation. Averbeck, Dietrich Cellular Responses at Low Doses of Ionizing Radiation. Azzam, Edouard Adaptive Responses to Low Dose/Low Dose-Rate ?-Rays in Normal Human Fibroblasts: The Role of Oxidative Metabolism. Bailey, Susan The Role of Telomere Dysfunction in Driving Genomic Instability. Balajee, Adayabalam Low Dose Radiation Induced DNA Damage Signaling and Repair Responses in Human 3-Dimensional Skin Model System. Barcellos-Hoff, Mary Helen Imaging Bioinformatics for Mapping Multidimensional Responses. Barcellos-Hoff, Mary Helen Biological Response to Radiation Mediated through the Microenvironment and

83

Low Dose Radiation Research Program: National Laboratories  

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National Laboratories National Laboratories The Low Dose Radiation Program funding encompasses several Scientific Focus Areas (SFAs). The SFAs fund merit-reviewed research at DOE national laboratories. This management approach was created in 2008 by the Office of Biological and Environmental Research (BER) within the U.S. Department of Energy's (DOE's) Office of Science. PNNL's Low Dose Radiation Research Program Scientific Focus Area Linear and Nonlinear Tissue-Signaling Mechanisms in Response to Low Dose and Low Dose-Rate Radiation This program is funded as a U.S. Department of Energy Scientific Focus Area (SFA), and is an integrated cooperative program to understand low dose radiation effects in a complex model system. Coordinating Multidisciplinary Expertise The SFAs are designed to take advantage of the multidisciplinary,

84

Design of a DICOM image-based program for estimating patient exposure dose in computed tomography  

Science Conference Proceedings (OSTI)

During the past decade, there has been a notable worldwide increase in the number of computed tomographic (CT) examinations. Since the radiation exposure to the patient during CT examinations is relatively high, it is important to optimize the dose so ... Keywords: DICOM, computed tomography (CT), effective dose

Shuji Yamamoto; Tetsuya Horiuchi; Junko Sekiguchi; Shigeo Wada; Mitsuru Komizu; Takami Yamaguchi

2007-04-01T23:59:59.000Z

85

Low Dose Radiation Program: Links - Agencies with Radiation Regulatory  

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Agencies with Radiation Regulatory Concerns and Involvement Agencies with Radiation Regulatory Concerns and Involvement Biological Effects of Low Level Exposures (BELLE) Canadian Nuclear Safety Commission Center for Risk Excellence Health Protection Agency The Health Risks of Extraterrestrial Environments International Commission on Radiation Units and Measurements, Inc. International Commission on Radiological Protection (ICRP) International Radiation Protection Association (IRPA) NASA Space Radiation Program National Academy of Sciences (NAS) Nuclear and Radiation Studies Board National Aeronautics and Space Administration (NASA) NASA OBRR Task Book Publication National Council on Radiation Protection (NCRP) National Institute of Environmental Health Sciences (NIEHS) National Toxicology Program (NTP) Occupational Safety and Health Administration (OSHA)

86

Low Dose Radiation Research Program: Thomas Weber  

NLE Websites -- All DOE Office Websites (Extended Search)

2005 Workshop: A Paracrine Signal Mediates The Cell Transformation Response To Low Dose Gamma Radiation in JB6 Cells. Weber, T.J., Siegel, R.W., Markillie, L.M., Chrisler,...

87

Low Dose Radiation Research Program: Molecular Characterization...  

NLE Websites -- All DOE Office Websites (Extended Search)

the Role of SOD Genes in Mammalian Cellular Response to Low Dose Ionizing Radiation Chaun-Yuan Li Duke University Medical Center Durham, NC Why this Project? To evaluate the roles...

88

Low Dose Radiation Research Program: Micronutrient Deficiency...  

NLE Websites -- All DOE Office Websites (Extended Search)

DNA damage is appreciable and increases with age,3;4 Our aim is to compare low dose radiation with micronutrient deficiency, and endogenous damage by a variety of measures...

89

Low Dose Radiation Research Program: Universities  

NLE Websites -- All DOE Office Websites (Extended Search)

Universities Universities | Duke University | Loma Linda University | Northwestern University | University of Chicago | University of California Davis | Northwestern University University of Chicago University of California Davis Effects of Low Dose Irradiation on NF-κB Signaling Networks and Mitochondria Principal Investigator: Dr. Gayle Woloschak DOE Low Dose Research Program Projects Low dose-low dose rate irradiation leads to long term changes in numbers of mitochondria and mitochondrial genomes - Principal Investigator: Gayle Woloschak, Professor, Department of Radiation Oncology, Northwestern University, Chicago, IL, USA NF-κB-mediated pro-survival network in low dose radiation-induced adaptive protection - Principal Investigator: Jian Jian Li, Professor, Department of Radiation Oncology, University of California Davis, Davis,

90

Radiation Leukaemogenesis at Low Doses  

NLE Websites -- All DOE Office Websites (Extended Search)

myeloid leukaemia development at high and low doses. References 1. Cook WD, McCaw BJ, Herring C, John DL, Foote SJ, Nutt SL and Adams JM (2004). PU.1 is a suppressor of myeloid...

91

Low Dose Radiation Research Program: Research Institutions  

NLE Websites -- All DOE Office Websites (Extended Search)

Institutions Institutions Lovelace Respiratory Research Institute Biological Bases for Radiation Adaptive Responses in the Lung-Lovelace Respiratory Research Institute, Albuquerque, NM USA Contact: Dr. Bobby R. Scott Program Objective Our research focuses on elucidating the biological bases for radiation adaptive responses in the lung and for suppressing lung cancer, and to use the knowledge gained to produce an improved systems-biology-based, risk model for lung cancer induction by low-dose, low linear-energy-transfer (LET) radiation. Research was initiated in October 2009. This research should help foster a new era of low-dose radiation risk/benefit assessment. It will have important implications for possible use of low-dose diagnostic radiation (e.g., X-rays) in cancer therapy. It

92

RADIATION DOSE ESTIMATES TO ADULTS AND CHILDREN FROM VARIOUS  

NLE Websites -- All DOE Office Websites (Extended Search)

RADIATION DOSE ESTIMATES TO ADULTS AND CHILDREN FROM VARIOUS RADIOPHARMACEUTICALS Latest Revision Date: 43096 Radiation Internal Dose Information Center Oak Ridge Institute for...

93

Latest Research, Effects from Low Dose Exposure, Response to...  

NLE Websites -- All DOE Office Websites (Extended Search)

Program Draft of Low Dose Program History 1998-2008 Available for Review and Comment The history of the first decade of DOE Low Dose Radiation Research Program has been written by...

94

Low Dose Radiation Research Program: Adaptive Response of Mouse Skin  

NLE Websites -- All DOE Office Websites (Extended Search)

Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1 Authors: Jian Jian Li, Kazi M. Ahmed, Ming Fan, Shaozhong Dong, Douglas R. Spitz, and Cheng-Rong Yu Institutions: Division of Molecular Radiobiology, Purdue University School of Health Sciences, West Lafayette, Indiana; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland Gene expression profiles demonstrate that a group of key stress-responsive genes are associated with radiation exposure and may contribute to cellular

95

Low Dose Radiation Research Program: Molecular Characterization of Survival  

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Survival Advantage, Bystander Effect, and Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure Mohan Natarajan University of Texas Health Science Center Why this Project? To understand the molecular link between the activation of NF-kB and cellular outcomes such as better cell survival after low-LET radiation and to determine whether low dose radiation-induced NF-kB signaling can mediate telomerase activation and thus confer enhanced cell survival of normal aortic endothelial cells. Project Goals To determine whether low-linear energy transfer (LET) radiation can cause a positive feedback signal initiated by the activation of the NF-kB. To examine one of the mechanisms involving TNF-a as a signaling mediator, which could mediate the bystander effect through the generation

96

Contribution of maternal radionuclide burdens to prenatal radiation doses  

SciTech Connect

This report describes approaches to calculating and expressing radiation doses to the embryo/fetus from internal radionuclides. Information was obtained for selected, occupationally significant radioelements that provide a spectrum of metabolic and dosimetric characteristics. Evaluations are also presented for inhaled inert gases and for selected radiopharmaceuticals. Fractional placental transfer and/or ratios of concentration in the embryo/fetus to that in the woman were calculated for these materials. The ratios were integrated with data from biokinetic transfer models to estimate radioactivity levels in the embryo/fetus as a function of stage of pregnancy and time after entry into the transfer compartment or blood of the pregnant woman. These results are given as tables of deposition and retention in the embryo/fetus as a function of gestational age at exposure and elapsed time following exposure. Methodologies described by MIRD were extended to formalize and describe details for calculating radiation absorbed doses to the embryo/fetus. Calculations were performed using a model situation that assumed a single injection of 1 {mu}Ci into a woman`s blood; independent calculations were performed for administration at successive months of pregnancy. Gestational -stage-dependent dosimetric tabulations are given together with tables of correlations and relationships. Generalized surrogate dose factors and categorizations are provided in the report to provide for use in operational radiological protection situations. These approaches to calculation yield radiation absorbed doses that can be converted to dose equivalent by multiplication by quality factor. Dose equivalent is the most common quantity for stating prenatal dose limits in the United States and is appropriate for the types of effect that are usually associated with prenatal exposure. If it is desired to obtain alternatives for other purposes, this value can be multiplied by appropriate weighting factors.

Sikov, M.R.; Hui, T.E.

1996-05-01T23:59:59.000Z

97

Radiation dose from cigarette tobacco  

SciTech Connect

The radioactivity in tobacco leaves collected from 15 different regions of Greece before cigarette production was studied in order to estimate the effective dose from cigarette tobacco due to the naturally occurring primordial radionuclides, such as {sup 226}Ra and {sup 210}Pb of the uranium series and {sup 228}Ra of the thorium series and/or man-made produced radionuclides, such as {sup 137}Cs of Chernobyl origin. Gamma-ray spectrometry was applied using Ge planar and coaxial type detectors of high resolution and high efficiency. It was concluded that the annual effective dose due to inhalation for adults (smokers) for {sup 226}Ra varied from 42.5 to 178.6 {mu}Sv y{sup -1} (average 79.7 {mu}Sv y{sup -1}), while for {sup 228}Ra from 19.3 to 116.0 {mu}Sv y{sup -1} (average 67.1 {mu}Sv y{sup -1}) and for {sup 210}Pb from 47.0 to 134.9 {mu}Sv y{sup -1} (average 104.7 {mu}Sv y{sup -1}), that is the same order of magnitude for each radionuclide. The sum of the effective dose of the three natural radionuclides varied from 151.9 to 401.3 {mu}Sv y{sup -1} (average 251.5 {mu}Sv y{sup -1}). The annual effective dose from {sup 137}Cs of Chernobyl origin was three orders of magnitude lower as it varied from 70.4 to 410.4 nSv y{sup -1} (average 199.3 nSv y{sup -1})

Papastefanou, C. [Aristotle University of Thessaloniki, Atomic and Nuclear Physics Laboratory, Thessaloniki 54124 (Greece)

2008-08-07T23:59:59.000Z

98

Low Dose Radiation Research Program: Assessing Biological Function of DNA  

NLE Websites -- All DOE Office Websites (Extended Search)

Assessing Biological Function of DNA Damage Response Genes Assessing Biological Function of DNA Damage Response Genes Larry H. Thompson Lawrence Livermore National Laboratory Why This Project To understand the relative importance of individual DNA repair and DNA-damage response pathways to the recovery of mammalian cells after exposure to low doses of ionizing radiation (IR). This understanding may lead to better ways of setting limits on human exposure to IR. In spite of the discovery of many mammalian DNA repair genes, our current knowledge of how many of these genes contribute to cellular recovery from IR exposure is quite limited. Project Goals Measure cellular responses at doses in the 5-100 cGy range, which generally cause changes too small to detect in normal, repair-proficient cells Focus on DNA double-strand breaks (DSBs) and DNA oxidative base

99

Low Dose Radiation Research Program: Low Dose Response of Respiratory Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Response of Respiratory Cells in Intact Tissues and Reconstituted Response of Respiratory Cells in Intact Tissues and Reconstituted Tissue John Ford Department of Nuclear Engineering Texas A & M University Why this Project? Using the well-established rat trachea model to test the hypothesis that normal respiratory epithelial cells transmit signals to neighboring cells in response to very low dose radiation exposure. Project Goals By comparing the responses shown by cells in these normal rodent respiratory tissues to those seen for human respiratory epithelial cells in reconstituted tissue constructs, it will be possible to better understand the responds in human respiratory cells in vivo. These studies will characterize responses after exposure to a variety of radiation types and dose distributions. Experimental Approach

100

Low-Dose Ionizing Radiation Alters the Epigenome of the Avy Mouse  

NLE Websites -- All DOE Office Websites (Extended Search)

Medical Center Abstract Background: Humans have evolved and thrived amidst constant low-dose (0-10 cGy) background radiation exposure from natural sources. Currently, however, the...

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Health Impacts from Acute Radiation Exposure  

SciTech Connect

Absorbed doses above1-2 Gy (100-200 rads) received over a period of a day or less lead to one or another of the acute radiation syndromes. These are the hematopoietic syndrome, the gastrointestinal (GI) syndrome, the cerebrovascular (CV) syndrome, the pulmonary syndrome, or the cutaneous syndrome. The dose that will kill about 50% of the exposed people within 60 days with minimal medical care, LD50-60, is around 4.5 Gy (450 rads) of low-LET radiation measured free in air. The GI syndrome may not be fatal with supportive medical care and growth factors below about 10 Gy (1000 rads), but above this is likely to be fatal. Pulmonary and cutaneous syndromes may or may not be fatal, depending on many factors. The CV syndrome is invariably fatal. Lower acute doses, or protracted doses delivered over days or weeks, may lead to many other health outcomes than death. These include loss of pregnancy, cataract, impaired fertility or temporary or permanent sterility, hair loss, skin ulceration, local tissue necrosis, developmental abnormalities including mental and growth retardation in persons irradiated as children or fetuses, radiation dermatitis, and other symptoms listed in Table 2 on page 12. Children of parents irradiated prior to conception may experience heritable ill-health, that is, genetic changes from their parents. These effects are less strongly expressed than previously thought. Populations irradiated to high doses at high dose rates have increased risk of cancer incidence and mortality, taken as about 10-20% incidence and perhaps 5-10% mortality per sievert of effective dose of any radiation or per gray of whole-body absorbed dose low-LET radiation. Cancer risks for non-uniform irradiation will be less.

Strom, Daniel J.

2003-09-30T23:59:59.000Z

102

Health Physics Society Specialists in Radiation Safety Radiation Exposure and Pregnancy  

E-Print Network (OSTI)

Everyone is exposed to radiation every day. People are continuously exposed to low-level radiation found in food, soils, building materials, and the air and from outer space. All of this radiation originates from naturally occurring sources. For example, bananas contain naturally occurring radioactive potassium-40 and air contains radon, a radioactive gas. Your average natural background radiation dose * is about 3.0 mSv (300 mrem) each year (millisieverts and millirem are units of radiation dose, much like a gram or an ounce is a unit of weight). In addition to natural background radiation, you may be exposed to radiation from medical x rays and medical radiation tests or treatments. If you think, or there is a possibility, that you may be pregnant and need a medical x-ray or radiation procedure, the information below will help answer your question Does a medical procedure involving radiation increase my babys health risks? What are the health risks from medical x rays or radionuclide medical tests performed during pregnancy? There is a lot of reliable information about the effects of radiation exposure during pregnancy. Potential radiation effects vary depending on the fetal stage of development and the magnitude of the doses. Our best knowledge indicates that there is a threshold below which negative effects are not observed. According to the American College of Radiology, routine x rays of a mothers abdomen, back, hips, and pelvis are not likely to pose a serious risk to the child (ACR/RSNA 2010). However, certain procedures (such as a computerized tomography [CT scan] or a lower GI fluoroscope exam) to the mothers stomach or hips may give higher doses. If you are administered a radioactive drug (nuclear medicine), radioactivity in your urine or intestines could give a moderate dose to the fetus, and some compounds can cross the placenta *Words in italics are defined in the Glossary on page 3.

Melissa Arch; At Immanuel St. Josephs

2010-01-01T23:59:59.000Z

103

Low Dose Ionizing Radiation Modulates Immune Function New Project Overview  

NLE Websites -- All DOE Office Websites (Extended Search)

Modulates Immune Function New Project Overview Modulates Immune Function New Project Overview Gregory Nelson Loma Linda University Abstract The immune system provides the first line of defense for exposures to environmental hazards. Protective immunity mechanisms using innate or adaptive responses are employed to mitigate acute challenges or amplify the readiness of the system to respond to future challenges. Some stimuli lead to amplified inflammatory reactions such as delayed hypersensitivity which is required for immunity to parasites and can also lead to adverse consequences such as contact dermatitis. Radiation exposure has the potential to aggravate hypersensitivity reactions as well as to suppress protective immunity. Ionizing radiation at high doses has long been recognized as highly effective in destroying cells of the immune system,

104

Agriculture-related radiation dose calculations  

SciTech Connect

Estimates of radiation dose to the public must be made at each stage in the identification and qualification process leading to siting a high-level nuclear waste repository. Specifically considering the ingestion pathway, this paper examines questions of reliability and adequacy of dose calculations in relation to five stages of data availability (geologic province, region, area, location, and mass balance) and three methods of calculation (population, population/food production, and food production driven). Calculations were done using the model PABLM with data for the Permian and Palo Duro Basins and the Deaf Smith County area. Extra effort expended in gathering agricultural data at succeeding environmental characterization levels does not appear justified, since dose estimates do not differ greatly; that effort would be better spent determining usage of food types that contribute most to the total dose; and that consumption rate and the air dispersion factor are critical to assessment of radiation dose via the ingestion pathway. 17 refs., 9 figs., 32 tabs.

Furr, J.M.; Mayberry, J.J.; Waite, D.A.

1987-10-01T23:59:59.000Z

105

Low Dose Radiation Research Program: Depletion of the Vertebrate...  

NLE Websites -- All DOE Office Websites (Extended Search)

Laboratory, Berkeley, California To better understand the responses to low dose ionizing radiation, we proposed in Aim 1 of our Low Dose grant to use dominant-negative...

106

Low Dose Radiation Research Program Website ?? Highlighting...  

NLE Websites -- All DOE Office Websites (Extended Search)

Website Highlighting Low Dose Research Bill Morgan Pacific Northwest National Laboratory Abstract The Low Dose Radiation Research Programs website is found at http:...

107

Low Dose Radiation Research Program: Genomic Instability and...  

NLE Websites -- All DOE Office Websites (Extended Search)

Genomic Instability and Low Dose Low Dose Rate Radiation. Authors: Lei Huang, Suzanne Grim, William F. Morgan Institutions: University of Maryland. Humans will always receive...

108

Monitoring exposure to atomic bomb radiation by somatic mutation  

SciTech Connect

Atomic bomb survivors are a population suitable for studying the relationship between somatic mutation and cancer risk because their exposure doses are relatively well known and their dose responses in terms of cancer risk have also been thoroughly studied. An analysis has been made of erythrocyte glycophorin A (GPA) gene mutations in 1,226 atomic bomb survivors in Hiroshima and Nagasaki. The GPA mutation frequency (Mf) increased slightly but significantly with age at the time of measurement and with the number of cigarettes smoked. After adjustment for the effect of smoking, the Mf was significantly higher in males than in females and higher in Hiroshima than in Nagasaki. All of these characteristics of the background GPA Mf were in accord with those of solid tumor incidence obtained from an earlier epidemiological study of A-bomb survivors. Analysis of the dose effect on Mf revealed the doubling dose to be about 1.20 Sv and the minimum dose for detection of a significant increase to be about 0.24 Sv. No significant dose effect for difference in sex, city, or age at the time of bombing was observed. Interestingly, the doubling dose for the GPA Mf approximated that for solid cancer incidence (1.59 Sv). And the minimum dose for detection was not inconsistent with the data for solid cancer incidence. The dose effect was significantly higher in those diagnosed with cancer before or after measurement than in those without a history of cancer. These findings are consistent with the hypothesis that somatic mutations are the main cause of excess cancer risk from radiation exposure. 27 refs., 2 figs.

Akiyama, Mitoshi; Kyoizumi, Seishi; Kusunoki, Yoichiro [Radiation Effects Research Foundation, Hiroshima (Japan)] [and others

1996-05-01T23:59:59.000Z

109

Low Dose Radiation Research Program: Research Highlights - Collateral  

NLE Websites -- All DOE Office Websites (Extended Search)

Collateral Damage Collateral Damage Using targeted irradiation to understand radiation-induced effects in bystander cells chromosomal A typical example of chromosomal instability induction measured by chromosome-type aberrations in primary human lymphocytes at delay time post-irradiation of a fraction of the cell population. Similar types of aberrations were observed in whole irradiated population but were not observed in untreated cells. Munira Kadhim Background: It has long been understood that radiation exposure can influence cellular changes. Studies indicate that even very low doses of high linear energy transfer (LET) alpha-particle irradiation, such as that from environmental radon, can affect cells. Radiation-induced genomic instability can be observed in the progeny of irradiated cells and as a

110

Molecular mechanisms and cellular consequences of low-dose exposure to ionizing  

NLE Websites -- All DOE Office Websites (Extended Search)

mechanisms and cellular consequences of low-dose exposure to ionizing mechanisms and cellular consequences of low-dose exposure to ionizing radiation Andrew J. Wyrobek 1 , Francesco Marchetti 1 , Xiu Lowe 1 , Xiaochen Lu 2 , Terumi Kohwi- Shigematsu 1 , Brian Davy 1 , Thomas E. Schmid 1 , Sylvia Ahn 1 , Tarlochan Nijjar 1 Matthew A. Coleman 2 , Contact information: ajwyrobek@gmail.com 1 Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 2 BioSciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA. The objectives of this research are to characterize the genome-wide molecular responses to low-dose ionizing radiation (<10cGy), to identify tissue and cell-type specific differences in pathways responses, and to identify the pivotal molecular pathway responses that control risks to genome integrity and health. This project utilizes mouse in

111

Correlation of External Exposure and Dose Equivalent Rates with Uranium Surface Contamination  

SciTech Connect

This report provides both calculated estimates and measured values of exposure in air and tissue dose from external penetrating radiation at a distance of 1 m from uranium contamination on surfaces at the Oak Ridge Y-12 Plant, in support of the Y-12 Site Radiological Characterization Study. Calculated values are based on the total energy from gamma rays and X rays emitted by uranium and its shordaughters at secular equilibrium. Results of a small number of measurements are provided for comparison. Dose rate values derived here are limited to those of external penetrating radiation from distributed sources with limited surface area and from point sources.

Ashley, J.C.; Bogard, J.S.; Brown, K.S.; England, C.A.; Hamm, R.N.; Turner, J.E.

1999-06-01T23:59:59.000Z

112

Low Dose Radiation Research Program: Effects of Low Doses of Radiation on  

NLE Websites -- All DOE Office Websites (Extended Search)

Abstract Abstract Title: Effects of Low Doses of Radiation on DNA Repair (PNNL Project # 42699) Authors: Eric J. Ackerman, Ph.D. Institutions: Pacific Northwest National Laboratory Richland, WA We developed a functional assay to measure the effects of LDR on repair of many different lesions representative of those found in cells as consequences of normal oxidative metabolism, as well as those caused by radiation. Currently only 1/10th attomole =105 damaged molecules/cell and 3000 cells/measurement are required. We have found that even low doses (10 rad) exert measurable effects on DNA repair. Interestingly, the amount of DNA repair increases at 10-50 rads, plateaus, and then increases even further at higher doses well below doses where radiation-induced lethality

113

Low Dose Radiation Research Program: Effects of Low Doses of Radiation on  

NLE Websites -- All DOE Office Websites (Extended Search)

Low Doses of Radiation on DNA Repair Low Doses of Radiation on DNA Repair Eric Ackerman Pacific Northwest National Laboratory Why this Project? Even low doses (0.1 Gy) exert measurable effects on DNA repair. The first-known oxidative lesion repaired only by nucleotide excision repair found in normal cells is cyclo-dA. This lesion is found in normal cells and thought to be a byproduct of oxidative metabolism. When this lesion occurs, it stimulates repair. If repair is stimulated by low dose radiation, there are some implications for human health. For example, do some individuals exhibit a greater, lower, or no stimulation to certain DNA lesions? If there are population polymorphism that influence DNA repair, then it would be possible to use our assay for screening individuals for repair sensitivity.

114

Environmental radiation exposure: Regulation, monitoring, and assessment  

Science Conference Proceedings (OSTI)

Radioactive releases to the environment from nuclear facilities constitute a public health concern. Protecting the public from such releases can be achieved through the establishment and enforcement of regulatory standards. In the United States, numerous standards have been promulgated to regulate release control at nuclear facilities. Most recent standards are more restrictive than those in the past and require that radioactivity levels be as low as reasonably achievable (ALARA). Environmental monitoring programs and radiological dose assessment are means of ensuring compliance with regulations. Environmental monitoring programs provide empirical information on releases, such as the concentrations of released radioactivity in environmental media, while radiological dose assessment provides the analytical means of quantifying dose exposures for demonstrating compliance.

Chen, S.Y.; Yu, C.; Hong, K.J.

1991-01-01T23:59:59.000Z

115

Functional Proteomic Pattern Identification under Low Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

The goal of this study is to explore and to understand the dynamic responses of signaling pathways to low dose ionizing radiation (IR). Low dose radiation (10 cGy or lower) affects several signaling pathways including DNA repair, survival, cell cycle, ... Keywords: low dose radiation, functional proteomics

Young Bun Kim; Jean Gao; Ying Dong; Chin-Rang Yang

2008-11-01T23:59:59.000Z

116

Low Dose Radiation Research Program: Kenneth T. Bogen  

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T. Bogen Lawrence Livermore National Laboratory Technical Abstracts 2002 Workshop: Low-dose dose-response of proliferating human cells exposed to low dose rate g-radiation. Enns,...

117

Low-Dose Ionizing Radiation Alters the Epigenome of the Avy Mouse  

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Ionizing Radiation Alters the Epigenome of the A Ionizing Radiation Alters the Epigenome of the A vy Mouse Autumn Bernal 1,2,3 , Dale Huang 1 , Yue Li 4 , Dana Dolinoy 5 , and Randy Jirtle 1 Department of Radiation Oncology 1 , University Program in Genetics and Genomic 2 , Integrated Toxicology & Environmental Health Program 3 , Department of Community and Family Medicine 4 , Duke University Medical Center, Durham, NC, USA, Department of Environmental and Health Sciences, University of Michigan, Ann Arbor, MI, USA 4 Background: Humans have evolved and thrived amidst constant low-dose (0-10 cGy) background radiation exposure from natural sources. Currently, however, the frequency of exposures to low doses of radiation is increasing due to man-made sources such as diagnostic imaging and nuclear power. This increased exposure has led to concerns amongst the general public and the government about the

118

Low Dose Radiation Research Program: Low Dose Ionizing Radiation-Induced  

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Low Dose Ionizing Radiation-Induced Effects in Irradiated and Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated cells: Pathways Analysis in Support of Risk Assessment. Authors: B.E. Lehnert, R. Cary, D. Gadbois, and G. Gupta. Institutions: Bioscience Division, Los Alamos National Laboratory. The scientific literature presents a confusing picture concerning health risks due to low dose ionizing radiation (LDIR), e.g., <1-10 cGy. Some effects of LDIR such as enhanced rates of cell proliferation and the induction of radioadaptation may be benign under some circumstances. Other evidence suggests LDIR can be hazardous and that a threshold for potentially detrimental responses, e.g., increases in intracellular reactive oxygen species (ROS), increases in sister chromatid exchanges (SCE), alterations in gene or protein expression profiles, and increased

119

Low Dose Radiation Research Program: Original Research Program Plan  

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Original Research Program Plan Original Research Program Plan Biological Effects of Low Dose and Dose Rate Radiation Prepared for the Office of Biological and Environmental Research by The Low Dose Radiation Research Program Plan Subcommittee of the Biological and Environmental Research Advisory Committee. II. Table of Contents Face Page Table of Contents Executive Summary Introduction Program Outline Low Dose Radiation vs. Endogenous Oxidative Damage - The Same or Different? Key Question Description Decision Making Value Recommendations and Costs Understanding Biological Responses to Radiation And Endogenous Damage Key Question Description Decision Making Value Recommendations and Costs Thresholds for Low Dose Radiation - Fact or Fiction? Key Question Description Decision Making Value Recommendations and Costs

120

Low-Dose Radiation Cataract and Genetic Determinants of Radiosensitivity  

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Cataract and Genetic Determinants of Radiosensitivity Cataract and Genetic Determinants of Radiosensitivity Kleiman, N.J. 1 , Smilenov, L.B. 2 , Brenner, D.J. 2 and Hall, E.J. 2 1 Department of Environmental Health Sciences, Mailman School of Public Health & 2 The Center for Radiological Research, College of Physicians & Surgeons, Columbia University, New York 10032 The lens of the eye is one of the most radiosensitive tissues in the body. Ocular ionizing radiation exposure results in characteristic, dose related, progressive lens changes leading to cataract formation. While initial, early stages of such opacification may not cause visual disability, the severity of such changes progressively increases with dose until vision is impaired and cataract extraction surgery may be required. The

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121

Low Dose Radiation Research Program: William F. Morgan  

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William F. Morgan William F. Morgan Pacific Northwest National Laboratory PO Box 999 Richland, Washington About this Project Projects Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation. Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells. Genetic Factors Affecting Susceptibility to Low-Dose Radiation Mechanisms of Adaptive Responses and Genomic Instability Induced by Low Dose/ Low Dose Rate Radiation Technical Abstracts 2006 Workshop: Using a Low-LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation Sowa, M.B., Goetz, W., Baulch, J., and Morgan, W.F. Genetic Factors Affecting Susceptibility to Low-Dose Radiation

122

Low-Dose/Dose-Rate Low-LET Radiation Protects Us from Cancer  

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Dose/Dose-Rate Low-LET Radiation Protects Us from Cancer Dose/Dose-Rate Low-LET Radiation Protects Us from Cancer Bobby R. Scott, Ph.D. and Jennifer D. Di Palma Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE Albuquerque, NM 87108 USA Life on earth evolved in a low-level ionizing radiation environment comprised of terrestrial radiation and cosmic rays. Today we all reside in an ionizing radiation environment comprised of both natural background radiation and radiation from human activities (e.g., Chernobyl accident). An evolutionary benefit of the interaction of low-level, low linear-energy-transfer (LET) ionizing radiation with mammalian life forms on earth is adapted protection. Adapted protection involves low-dose/dose-rate, low-LET radiation induced high-fidelity DNA repair in cooperation with normal apoptosis (presumed p53

123

Low Dose Radiation Research Program: Computational Modeling of Biochemical  

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Computational Modeling of Biochemical Pathways Linking Ionizing Computational Modeling of Biochemical Pathways Linking Ionizing Radiation to Cell Cycle Arrest, Apoptosis, and Tumor Incidence Authors: Yuchao Maggie Zhao and Rory Conolly Institutions: Center for Computational Systems Biology CIIT Centers for Health Research Long-Range Goal: To develop an integrated, computational framework for the prediction of low-dose-response to ionizing radiation (IR) in people. Methodology: To provide a flexible framework to evaluate mechanisms of cellular adaptive responses after exposure to IR, three progressively more complicated descriptions of biochemical pathways linking DNA damage with cell-cycle checkpoint control and apoptosis were developed. These descriptions focus on p53-dependent checkpoint arrest and apoptosis, p73-dependent apoptosis, and Chk2-dependent checkpoint arrest,

124

Apoptosis as a Mechanism for Low Dose Radiation-and Amifostine-Mediated  

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Apoptosis as a Mechanism for Low Dose Radiation- and Amifostine-Mediated Apoptosis as a Mechanism for Low Dose Radiation- and Amifostine-Mediated Chromosomal Inversion Responses Pam Sykes Flinders University and Medical Centre Abstract Low dose radiation and the chemical radioprotector amifostine have both been shown to protect cells from the immediate and delayed effects of radiation exposure. They display a number of distinct similarities including their ability to protect cells against radiation-induced DNA damage, radiation-induced cell death and metastases formation. Amifostine, which protects cells from the toxic effects of ionizing radiation, has a broad range of activities including free radical scavenging, polyamine-like DNA binding, and induction of hypoxia and redox-regulated genes. Amifostine’s ability to protect cells is often

125

POSITION STATEMENT DOCUMENTING IONIZING RADIATION EXPOSURE IN THE ELECTRONIC HEALTH RECORD  

E-Print Network (OSTI)

IEEE-USA believes that maintaining an accurate record of a patients cumulative exposure to ionizing radiation can be of substantial value for clinical, health services management and research purposes. Excessive radiation can cause cancer, skin and bone marrow disease and a variety of other diseases. Radiation exposure can come from a number of sources, both natural and manmade. Over the lifetime of the individual, medical procedures, such as X-rays, Computed Tomography (CT) scans, and isotope radiation therapy, contribute significant radiation dosages. Monitoring the use of radiological procedures, measuring the radiation dose directly, and recording the dose in the Electronic Health Record (EHR) can help assess and reduce the risk posed by excessive radiation while optimizing the diagnostic value of these procedures. With these risks and benefits in mind, IEEE-USA recommends the following: 1. Health Level Seven International (HL7), the global authority responsible for standards for interoperability of health information technology, should add the appropriate "dose object " radiation parameters, as defined in the IHE Radiology Technical Framework Supplement, Radiation Exposure Monitoring (REM), to HL7/CDA format longitudinal electronic health records (EHRs), to create a longitudinal record of a patient's exposure to radiation resulting from medical procedures. These records should note both the procedure and estimated radiation dose from each procedure. 2. The Office of the National Coordinator for Health Information Technology (ONCHIT) should make radiation dose monitoring a part of meaningful use criteria for EHRs. 3. Healthcare accreditation organizations (JCAHO, NCQA and URAC), in collaboration with the American College of Radiologists (ACR), should continue

Adopted The Ieee-usa

2011-01-01T23:59:59.000Z

126

DOE 2008 Occupational Radiation Exposure October 2009  

Science Conference Proceedings (OSTI)

A major priority of the U.S. Department of Energy (DOE) is to ensure the health, safety, and security of DOE employees, contractors, and subcontractors. The Office of Health, Safety and Security (HSS) provides the corporate-level leadership and strategic vision necessary to better coordinate and integrate health, safety, environment, security, enforcement, and independent oversight programs. One function that supports this mission is the DOE Corporate Operating Experience Program that provides collection, analysis, and dissemination of performance indicators, such as occupational radiation exposure information. This analysis supports corporate decision-making and synthesizes operational information to support continuous environment, safety, and health improvement across the DOE complex.

U.S. Department of Energy, Office of Health, Safety and Security

2009-10-01T23:59:59.000Z

127

RECONSTRUCTION OF INDIVIDUAL DOSES DUE TO MEDICAL EXPOSURES FOR MEMBERS OF THE TECHA RIVER COHORT  

Science Conference Proceedings (OSTI)

Purpose: To describe a methodology for reconstruction of doses due to medical exposures for members of the Techa River Cohort (TRC) who received diagnostic radiation at the clinic of the Urals Research Center for Radiation Medicine (URCRM) in 19522005. To calculate doses of medical exposure for the TRC members and compare with the doses that resulted from radioactive contamination of the Techa River. Material and Methods: Reconstruction of individual medical doses is based on data on x-ray diagnostic procedures available for each person examined at the URCRM clinics and values of absorbed dose in 12 organs per typical x-ray procedure calculated with the use of a mathematical phantom. Personal data on x-ray diagnostic examinations have been complied in the computerized Registry of x-ray diagnostic procedures. Sources of information are archival registry books from the URCRM x-ray room (available since 1956) and records on x-ray diagnostic procedures in patient-case histories (since 1952). The absorbed doses for 12 organs of interest have been evaluated per unit typical x-ray procedure with account taken of the x-ray examination parameters characteristic for the diagnostic machines used at the URCRM clinics. These parameters have been evaluated from published data on technical characteristics of the x-ray diagnostic machines used at the URCRM clinics in 19521988 and taken from the x-ray room for machines used at the URCRM in 19892005. Absorbed doses in the 12 organs per unit typical x-ray procedure have been calculated with use of a special computer code, EDEREX, developed at the Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev. Individual accumulated doses of medical exposure have been calculated with a computer code, MEDS (Medical Exposure Dosimetry System), specifically developed at the URCRM. Results: At present, the Registry of x-ray diagnostic procedures contains information on individual x-ray examinations for over 9,500 persons including 6,415 TRC members. Statistical analysis of the Registry data showed that the more frequent types of examinations were fluoroscopy and radiography of the chest and fluoroscopy of the stomach and the esophagus. Average absorbed doses accumulated by year 2005 calculated for the 12 organs varied from 4 mGy for testes to 40 mGy for bone surfaces. Maximum individual medical doses could reach 500650 mGy and in some cases exceeded doses from exposure at the Techa River. Conclusions: For the first time the doses of medical exposure were calculated and analyzed for members of the Techa River Cohort who received diagnostic radiation at the URCRM clinics. These results are being used in radiation-risk analysis to adjust for this source of confounding exposure in the TRC.

Shagina, N. B.; Golikov, V.; Degteva, M. O.; Vorobiova, M. I.; Anspaugh, L. R.; Napier, Bruce A.

2012-11-01T23:59:59.000Z

128

Assessment of potential radiation exposures by uncontrolled recycle or reuse of radioactive scrap metals  

Science Conference Proceedings (OSTI)

With current waste monitoring technology it is reasonable to assume that much of the material designated as low-level waste, generated within nuclear facilities, is in fact uncontaminated. A criterion for uncontrolled disposal of low-level radioactive contaminated waste is that the radiation exposure of the public and of each individual caused by this disposal is so low that radiation protection measures need not be taken. The International Atomic Energy Agency (IAEA) suggests an annual effective dose of 10 {micro}Sv as a limit for the individual radiation dose and derived the initial control levels of residual radioactivity based on the Publication 30 of the International Commission on Radiological Protection (ICRP). In 1990, new recommendations on radiation protection standards were developed by ICRP to take into account new biological information related to the detriment associated with radiation exposure. Adoption of these recommendations necessitated a revision of the Commission's secondary limits contained in Publication 30. This study summarizes the potential radiation exposure from valuable scrap metal considered for uncontrolled recycle by new ICRP recommendations. Potential exposure pathways to people were analyzed and concentrations leading to an individual dose of 10 {micro}Sv/year were calculated for 14 key radionuclides. These potential radiation doses are compared with the results of previous study.

Lee, S.Y.; Lee, K.J.

1999-07-01T23:59:59.000Z

129

Occupational Radiation Exposure Analysis of US ITER DCLL TBM  

Science Conference Proceedings (OSTI)

This report documents an Occupational Radiation Exposure (ORE) analysis that was performed for the US International Thermonuclear Experimental Reactor (ITER) Dual Coolant Lead Lithium (DCLL) Test Blanket Module (TBM). This analysis was performed with the QADMOD dose code for anticipated maintenance activities for this TBM concept and its ancillary systems. The QADMOD code was used to model the PbLi cooling loop of this TBM concept by specifying gamma ray source terms that simulated radioactive material within the piping, valves, heat exchanger, permeator, pump, drain tank, and cold trap of this cooling system. Estimates of the maintenance tasks that will have to be performed and the time required to perform these tasks where developed based on either expert opinion or on industrial maintenance experience for similar technologies. This report details the modeling activity and the calculated doses for the maintenance activities envisioned for the US DCLL TBM.

Merrill, Brad J; Cadwallader, Lee C; Dagher, Mohamad

2007-08-01T23:59:59.000Z

130

Low Dose Radiation Research Program: Bruce E. Lehnert  

NLE Websites -- All DOE Office Websites (Extended Search)

E. Lehnert E. Lehnert Los Alamos National Laboratory Past Project Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated Cells: Pathways Analysis in Support of Risk Assessment. Technical Abstracts 2002 Workshop: Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated cells: Pathways Analysis in Support of Risk Assessment. Lehnert, B.E., Cary, R., Gadbois, D. and Gupta G. 2001 Workshop: Low Dose, Low Dose Rate Effects of Ionizing Radiation in Irradiated and Unirradiated Cells. Lehnert, B.E. 1999 Workshop: Low Dose, Low Dose Rate Effects of Ionizing Radiation in Irradiated and Unirradiated Cells. Lehnert, B.E. Publications Lehnert, B.E., Radiation bystander effects. U.S.Department of Energy Research News (March 6 issue) Goldberg, Z. and Lehnert, B.E. (2002). Radiation-induced effects in

131

Body radiation exposure in breast cancer radiotherapy: Impact of breast IMRT and virtual wedge compensation techniques  

Science Conference Proceedings (OSTI)

Purpose: Recent reports demonstrate a dramatically increased rate of secondary leukemia for breast cancer patients receiving adjuvant high-dose anthracycline and radiotherapy, and that radiation is an independent factor for the development of leukemia. This study aimed to evaluate the radiation body exposure during breast radiotherapy and to characterize the factors associated with an increased exposure. Patients and Methods: In a prospective cohort of 120 women, radiation measurements were taken from four sites on the body at the time of adjuvant breast radiotherapy. Multiple regression analysis was performed to analyze patient and treatment factors associated with the amount of scattered radiation. Results: For standard 50 Gy breast radiotherapy, the minimal dose received by abdominal organs is on average 0.45 Gy, ranging from 0.06 to 1.55 Gy. The use of physical wedges as a compensation technique was the most significant factor associated with increased scattered dose (p < 0.001), resulting in approximately three times more exposure compared with breast intensity-modulated radiation therapy (IMRT) and dynamic wedge. Conclusions: The amount of radiation that is scattered to a patient's body is consistent with exposure reported to be associated with excess of leukemia. In accordance with the As Low As Reasonably Achievable (ALARA) principle, we recommend using breast IMRT or virtual wedging for the radiotherapy of breast cancer receiving high-dose anthracycline chemotherapy.

Woo, Tony [Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada); Pignol, Jean-Philippe [Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada)]. E-mail: Jean-Philippe.Pignol@sw.ca; Rakovitch, Eileen [Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada); Vu, Toni [Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada); Hicks, Deanna [Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada); O'Brien, Peter [Department of Medical Physics, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada); Pritchard, Kathleen [Department of Medical Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada)

2006-05-01T23:59:59.000Z

132

Analysis of low dose radiation induced epigenetic modifications...  

NLE Websites -- All DOE Office Websites (Extended Search)

levels ofbiological organization when organisms are exposed to low doses (<0.1Gy) of irradiation.Recent work in determining the exact effects of low dose radiation have shown that...

133

Low Dose Radiation Research Program: Cytogenetic tests of Radiobiologi...  

NLE Websites -- All DOE Office Websites (Extended Search)

relevant low-dose range (less than 0.1 Gy). Relate chromosome damage to radiation-induced cancer. Research Approach By studying molecular mechanisms relevant to low doses and low...

134

Annual report shows potential INL radiation dose well below safe...  

NLE Websites -- All DOE Office Websites (Extended Search)

estimates that the dose from a chest X-ray is about 10 mrem and the dose from cosmic radiation during a 3 hour domestic airline flight is about 1 mrem. Operations at the...

135

Mechanisms Underlying Cellular Responses to Low Doses/Low LET Ionizing Radiation in Primary Haemopoietic Cells.  

NLE Websites -- All DOE Office Websites (Extended Search)

Mechanisms Underlying Cellular Responses to Low Doses/Low LET Ionizing Radiation Mechanisms Underlying Cellular Responses to Low Doses/Low LET Ionizing Radiation in Primary Haemopoietic Cells. Munira Kadhim 1 , Stefania Militi 1 , Debbie Bowler 1 , Denise Macdonald 1 and Kevin Prise 2 1 Radiation and Genome Stability Unit, MRC, Harwell, Didcot, Oxon, OX11 0RD, UK 2 Gray Cancer Institute ,PO Box 100, Mount Vernon Hospital, Northwood, HA6 2JR, UK Because the human population is genetically heterogeneous, it is important to understand the role that heterogeneity may play in radiation response. Exposure to ionizing radiation can lead to a suite of changes, including increased mutation rate, delayed reproductive cell death, and delayed chromosomal aberrations, all of which are manifestations of the complex genomic instability (GI) phenotype. Following exposure to either high LET

136

Low Dose Radiation Research Program: Proteomic and Biochemical...  

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proteomic changes including protein expression levels and post-translational modification due to low dose-rate ionizing radiation Expected Outcomes Increased differentiation...

137

Low Dose Radiation Research Program: 2011 Current Projects  

NLE Websites -- All DOE Office Websites (Extended Search)

Investigation of non-targeted effects of low dose ionizing radiation on the mammary gland utilizing three-dimensional culture models of mammary cells derived from mouse strains...

138

Low Dose Radiation Research Program: Research Highlights - Ionizing...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Energy Low Dose Radiation Research Program, and the Department of Defense Breast Cancer Research program and Prostate Cancer Research program. Researchers include Eva...

139

Low Dose Radiation Research Program: Assessing Biological Function...  

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Livermore National Laboratory under contract No. W-7405-ENG-48 and funded by the Low Dose Radiation Research Program, Biological and Environmental Research (BER), U.S....

140

Low Dose Radiation Research Program: Genetic Variation in Tissue...  

NLE Websites -- All DOE Office Websites (Extended Search)

Variation in Tissue Responses to Low-dose Radiation Eugene Rinchik Oak Ridge National Laboratory Why this Project? To address how individual genetic background affects tissue...

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Low dose radiation combines with the Src oncoproteinto transform...  

NLE Websites -- All DOE Office Websites (Extended Search)

Lawrence Berkeley National Laboratory, Berkeley CA 94720 Goal: Determine whether low dose radiation exerts persistent epigenetic effects that promote malignancy. Background and...

142

Low Dose Radiation Research Program: Bruce N. Ames  

NLE Websites -- All DOE Office Websites (Extended Search)

University of California, Berkeley Technical Abstracts 2002 Workshop: Comparison of Low-Dose Radiation, Endogenous Oxidants, and Micronutrient Deficiencies through Analyses of DNA...

143

Low Dose Radiation Research Program: Gene Expression Profiles...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Energy by the University of California, Lawrence Livermore National Laboratory under Contract No. W-7405-Eng-48 with funding from the DOE Low Dose Radiation Research Program...

144

Low Dose Radiation Research Program: Susan S. Wallace  

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Susan S. Wallace University of Vermont Past Funded Project Free Radical DNA Damage Produced Endogenously and by Low Dose Radiation in Human Cells: Quantitation, Consequences, and...

145

A Basic Overview of the Occupational Radiation Exposure Monitoring...  

NLE Websites -- All DOE Office Websites (Extended Search)

and dissemination of occupational radiation exposure information. The annual REMS report is a valuable tool for managing radiological safety programs and for developing...

146

ORISE: Worker Health Studies - Radiation Exposure Data Collection  

NLE Websites -- All DOE Office Websites (Extended Search)

Overview Argonne Electronic Medical Records System Beryllium Testing and Surveillance Radiation Exposure Information and Reporting System (REIRS) U.S. Department of Energy...

147

LOW DOSE PHOTON RADIATION-INDUCED CHANGES IN T HELPER LYMPHOCYTES  

NLE Websites -- All DOE Office Websites (Extended Search)

LOW DOSE PHOTON RADIATION-INDUCED CHANGES IN T HELPER LYMPHOCYTES LOW DOSE PHOTON RADIATION-INDUCED CHANGES IN T HELPER LYMPHOCYTES Daila S. Gridley 1,2 , Asma Rizvi 2 , Xian Luo 1 , Adeola Y. Makinde 2 , Steve Rightnar 1 , Jian Tian 1 , Melba L. Andres 1 , James M. Slater 1 , and Michael J. Pecaut 1,2 Departments of 1 Radiation Medicine and 2 Biochemistry & Microbiology Loma Linda University and Medical Center, Loma Linda, CA 92354 USA Health risks due to protracted low dose irradiation remain unclear. This project investigates T helper (Th) lymphocyte function and the cellular milieu in which they reside under conditions of low dose, low- linear energy transfer (LET) radiation exposure. The Th cells are important because they secrete cytokines essential for generating optimal immune defenses against tumor, virus-infected, and other

148

Measurements of cosmic radiation dose in subsonic commercial aircraft compared to the city-pair dose calculation  

SciTech Connect

The radiation dose received by passengers during flight on conventional jet aircraft was determined as a function of exposure to cosmic radiation, solar radiation, flight time, and flight path. The dosimetric measurements were made with thermoluminescent dosimeters (TLD's) and with emulsions of three types sealed in plastic packets. These packets were sent by air mail back and forth from Berkeley, California to five cities and a dose sufficiently above background for a satisfactory measurement was accumulated by the TLD's on one round trip and by the emulsions on three round trips. It was concluded that both experiments and theory show that the total doses received at present day conventional jet aircraft altitudes are considerably higher than those encountered in supersonic flights at much higher altitudes, even though the dose rate is lower at these lower altitudes, when the longer time of exposure at the lower altitudes is taken into consideration. Computer programs used in the dose calculations are included. (CH)

Wallace, R.

1973-07-16T23:59:59.000Z

149

Low Dose Radiation Program: Links - Low Dose Research in Japan...  

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Low Dose Research in Japan-Institutes and Facilities Atomic Bomb Disease Institute, Nagasaki University Institute for Environmental Sciences (IES) National Institute of...

150

Low Dose Radiation Research Program: A Variable Energy Soft X-ray  

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Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect Melvyn Folkard Gray Cancer Institute Why This Project The aim of this project is to determine the effects of low radiation doses using a machine that makes it possible to radiate one cell at a time. Our soft X-ray microprobe can irradiate individual cells, or locations within cells with defined doses and with sub-micron precision. We can use low doses approaching that of a single electron track, which is of relevance to environmental level exposures. Much of our work is concentrating on irradiating specified individual cells within cell populations to identify "bystander responses" where non-radiated cells respond to signals from nearby radiated cells. Higher energy x-rays are being generated to extend

151

Low Dose Radiation Research Program: Using a Low LET Electron Microbeam to  

NLE Websites -- All DOE Office Websites (Extended Search)

a Low LET Electron Microbeam to Investigate Non-Targeted Effects of a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation William F. Morgan Radiation Oncology Research Laboratory, Pacific Northwest National Laboratory Why this Project? To examine genomic instability and bystander effects as non-targeted effects associated with low dose radiation exposure. Project Goals To provides a robust, reliable, highly sensitive assay for detecting delayed events occurring in cells exposed to low doses of ionizing radiation. Experimental Approach To mimic radiation damage from gamma and x-ray sources, a low-LET electron microbeam that generates energetic electrons has been designed such that high-energy electrons deposit energy in a pre-selected subset of cells leaving neighboring cells unirradiated. Using a novel green fluorescence gene (GFP) reporter assay, a high through

152

The Mechanism of Low Dose Radiation Risk Associated with Diagnostic X-rays,  

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Mechanism of Low Dose Radiation Risk Associated with Diagnostic X-rays, Mechanism of Low Dose Radiation Risk Associated with Diagnostic X-rays, PET, and Gamma-rays Douglas Boreham McMaster University Abstract The goal of this project was to investigate low dose ionizing radiation effects associated with exposure to diagnostic computed tomography (CT) or positron emission tomography (PET) scans. Biological effects were evaluated in wild type and Trp53+/- heterozygous females, following in vivo exposure to diagnostic CT (75kVp, 200µ) or PET (18F-FDG) scans. The short term biological effects following CT or PET scans were evaluated in order to understand biological modification of mechanisms, such as DNA repair processes and apoptosis, that might alter long term cancer risk. Corresponding life-time cancer risk studies are in progress. Short-term

153

Low Dose Radiation Research Program: The Role of the Number and Spacing of  

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Program Workshop I Program Workshop I November 10-12, 1999, Washington, D.C. The Role of the Number and Spacing of Electron Tracks on the Consequences of Low Dose Irradiation Leslie A. Braby and J. R. Ford Nuclear Engineering, Texas A&M University, 129 Zachry, College Station, Texas. Summary: Biological mechanisms, which may influence the health risks resulting from very low dose radiation exposures, will be investigated using a collimated beam of electrons to simulate the irradiation patterns occurring with low dose exposures. Abstract: Ionizing radiation produces a variety of free radicals and chemical products that react to produce the same types of oxidative damage in a mammalian cell as produced by the normal metabolic activity of the cell. However, the damage produced by radiation is distributed differently

154

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary  

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Genetic susceptibility to low-dose ionizing radiation in the mouse mammary Genetic susceptibility to low-dose ionizing radiation in the mouse mammary gland as a means of understanding human risk for breast cancer Antoine M. Snijders Lawrence Berkeley National Laboratory Abstract Goal: Our goal is to develop an in vivo mechanistic model of genetic variation in the low-dose damage responses of mammary glands using inbred mice known to vary in their sensitivity to low-dose induced mammary gland cancer, and to develop molecular predictors for susceptibility or resistance to low-dose induced breast cancer. Background and Significance: It is increasingly believed that individuals differ in their genetic susceptibilities to environmental insults for diseases such as cancer. This concern is especially important for the large numbers of individuals receiving low-dose exposures in the nuclear energy

155

ORISE: Illness and Injury Surveillance, Radiation Exposure, and...  

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Surveillance Data, December 2012 (PDF) Technical Report: Health Surveillance of Rocky Flats Radiation Workers, April 2006 (PDF) Technical Basis Document for the Neutron Dose...

156

Low Dose Radiation Program: Links - Websites about Radiation  

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Websites About Radiation The ABC's of Nuclear Science A Teacher's Guide To The Nuclear Science Wall Chart Answers to Questions about Radiation and You Background Radiation:...

157

Work to save dose: contrasting effective dose rates from radon exposure in workplaces and residences against the backdrop of public and occupational limits  

Science Conference Proceedings (OSTI)

Office workers are exposed to radon while at work and at home. Though there has been a multitude of studies reporting the measurements of radon concentrations and potential lung and effective doses associated with radon and progeny exposure in homes, similar studies on the concentrations and subsequent effective dose rates in the non-mine workplaces are lacking. Additionally, there are few, if any, comparative analyses of radon exposures at more 'typical' workplace with residential exposures within the same county. The purposes of this study were to measure radon concentrations in office and residential spaces in the same county and explore the radiation dose implications. Sixty-five track-etch detectors were deployed in office spaces and 47 were deployed in residences, all within Los Alamos County, New Mexico, USA. The sampling periods for these measurements were generally about three months. The measured concentrations were used to calculate and compare effective dose rates resulting from exposure while at work and at home. Results showed that full-time office workers receive on average about 8 times greater exposure at home than while in the office (2.3 mSv yr-! versus 0.3 mSv yr-!). The estimated effective dose rate for a more homebound person was about 3 mSv yr-!. Estimating effective doses from background radon exposure in the same county as Los Alamos National Laboratory, with thousands of'radiological workers,' highlights interesting contrasts in radiation protection standards that span public and occupational settings. For example, the effective dose rate from background radon exposure in unregulated office spaces ranged up to 1.1 mSv yr-!, which is similar to the 1 mSv yr-! threshold for regulation ofa 'radiological worker,' as defined in the Department of Energy regulations for occupational exposure. Additionally, the estimated average effective dose total of> 3 mSv yf! from radon background exposure in homes stands in contrast to the 0.1 mSv yr-! air pathway effective public dose limit regulated by the Environmental Protection Agency for radioactive air emissions.

Whicker, Jeffrey J [Los Alamos National Laboratory; Mcnaughton, Michael W [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

158

Annexin A2 Regulates A Low Dose-Specific Stress Response To Radiation.  

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Annexin A2 Regulates A Low Dose-Specific Stress Response To Radiation. Thomas J. Annexin A2 Regulates A Low Dose-Specific Stress Response To Radiation. Thomas J. Weber (PI), Greg J. Newton, Ryan D. Quesenberry, Janani I. Shutthanandan, Nikki Bollinger, Heather E. Engelmann and Lee K. Opresko. Cell Biology and Biochemistry Group, Pacific Northwest National Laboratory, Richland, WA 99354. Previous studies have demonstrated that JB6 cells release cell transforming paracrine factors following exposure to a low dose of radiation (10 cGy). Investigation of secreted proteins by SDS-Page and silver stain led to the identification of a 36 kDa band whose levels were increased in medium from irradiated cells, relative to sham controls. The 36 kDa band was identified as annexin A2 by mass spectrometry. Western blot analysis confirmed a dose-dependent increase in annexin A2 levels associated with medium from

159

DOE Basic Overview of Occupational Radiation Exposure_2011 pamphlet  

SciTech Connect

This pamphlet focusses on two HSS activities that help ensure radiation exposures are accurately assessed and recorded, namely: 1) the quality and accuracy of occupational radiation exposure monitoring, and 2) the recording, reporting, analysis, and dissemination of the monitoring results. It is intended to provide a short summary of two specific HSS programs that aid in the oversight of radiation protection activities at DOE. The Department of Energy Laboratory Accreditation Program (DOELAP) is in place to ensure that radiation exposure monitoring at all DOE sites is precise and accurate, and conforms to national and international performance and quality assurance standards. The DOE Radiation Exposure Monitoring Systems (REMS) program provides for the collection, analysis, and dissemination of occupational radiation exposure information. The annual REMS report is a valuable tool for managing radiological safety programs and for developing policies to protect individuals from occupational exposure to radiation. In tandem, these programs provide DOE management and workers an assurance that occupational radiation exposures are accurately measured, analyzed, and reported.

ORAU

2012-08-08T23:59:59.000Z

160

Low Dose Radiation Research Program: Multi-cellular Crosstalk...  

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grown in microwell slide chambers will be irradiated with precise 100-mm-wide exposure stripes of dose to define the responses in exposed and bystander cells The time course of the...

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161

Mechanisms of Low Dose Radiation-induced T helper Cell Function  

SciTech Connect

Exposure to radiation above levels normally encountered on Earth can occur during wartime, accidents such as those at Three Mile Island and Chernobyl, and detonation of dirty bombs by terrorists. Relatively high levels of radiation exposure can also occur in certain occupations (low-level waste sites, nuclear power plants, nuclear medicine facilities, airline industry, and space agencies). Depression or dysfunction of the highly radiosensitive cells of the immune system can lead to serious consequences, including increased risk for infections, cancer, hypersensitivity reactions, poor wound healing, and other pathologies. The focus of this research was on the T helper (Th) subset of lymphocytes that secrete cytokines (proteins), and thus control many actions and interactions of other cell types that make up what is collectively known as the immune system. The Department of Energy (DOE) Low Dose Radiation Program is concerned with mechanisms altered by exposure to high energy photons (x- and gamma-rays), protons and electrons. This study compared, for the first time, the low-dose effects of two of these radiation forms, photons and protons, on the response of Th cells, as well as other cell types with which they communicate. The research provided insights regarding gene expression patterns and capacity to secrete potent immunostimulatory and immunosuppressive cytokines, some of which are implicated in pathophysiological processes. Furthermore, the photon versus proton comparison was important not only to healthy individuals who may be exposed, but also to patients undergoing radiotherapy, since many medical centers in the United States, as well as worldwide, are now building proton accelerators. The overall hypothesis of this study was that whole-body exposure to low-dose photons (gamma-rays) will alter CD4+ Th cell function. We further proposed that exposure to low-dose proton radiation will induce a different pattern of gene and functional changes compared to photons. Over the course of this research, tissues other than spleens were archived and with funding obtained from other sources, including the Department of Radiation Medicine at the Loma Linda University Medical Center, some additional assays were performed. Furthermore, groups of additional mice were included that were pre-exposed to low-dose photons before irradiating with acute photons, protons, and simulated solar particle event (SPE) protons. Hence, the original support together with the additional funding for our research led to generation of much valuable information that was originally not anticipated. Some of the data has already resulted in published articles, manuscripts in review, and a number of presentations at scientific conferences and workshops. Difficulties in reliable and reproducible quantification of secreted cytokines using multi-plex technology delayed completion of this study for a period of time. However, final analyses of the remaining data are currently being performed and should result in additional publications and presentations in the near future. Some of the most notable conclusions, thus far, are briefly summarized below: - Distribution of leukocytes were dependent upon cell type, radiation quality, body compartment analyzed, and time after exposure. Low-dose protons tended to have less effect on numbers of major leukocyte populations and T cell subsets compared to low-dose photons. - The patterns of gene and cytokine expression in CD4+ T cells after protracted low-dose irradiation were significantly modified and highly dependent upon the total dose and time after exposure. - Patterns of gene and cytokine expression differed substantially among groups exposed to low-dose photons versus low-dose protons; differences were also noted among groups exposed to much higher doses of photons, protons, and simulated SPE protons. - Some measurements indicated that exposure to low-dose photon radiation, especially 0.01 Gy, significantly normalized at least some adverse effects of simulated SPE protons, thereby suggesting that this l

Gridley, Daila S.

2008-10-31T23:59:59.000Z

162

Low Dose Radiation Research Program: Research Highlights - 2010  

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DNA Double-Strand Break Repair Capacities Before and After Exposure to Low DNA Double-Strand Break Repair Capacities Before and After Exposure to Low Dose Radiation Immunochemical detection of DSB foci in the nuclei of human fibroblasts. (A) γ-H2AX phospho-serine 139 foci (chromatin marker of DSBs; green). (B) ataxia-telangiectasia mutated phospho-serine 1981 foci (ATM, DNA damage-responsive kinase; red). (C) Merge of images A and B. (White arrows mark large γ-H2AX foci and coincident γ-H2AX/pATM foci that were positively scored; yellow arrows mark small γ-H2AX foci that lack corresponding pATM foci that were not scored.) Enlarge Image Immunochemical detection of DSB foci in the nuclei of human fibroblasts. (A) γ-H2AX phospho-serine 139 foci (chromatin marker of DSBs; green). (B) ataxia-telangiectasia mutated phospho-serine 1981 foci (ATM,

163

Low Dose Radiation Research Program: Induction of Genomic Instability in  

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Induction of Genomic Instability in vivo by Low Doses of 137Cs y Induction of Genomic Instability in vivo by Low Doses of 137Cs y rays, Authors: K. Rithidech1, E.B. Whorton2, M. Tungjai1, E. Ar-Bab1, S.R. Simon1, M. Tawde3 and C.W. Anderson3. Institutions: 1Pathology Department, Stony Brook University, NY 11794-8691, USA, 2University of Texas Medical Branch at Galveston, TX 77550-1047,3Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000. Information on potential health hazards of radiation at doses below or equal to the level traditionally requiring human radiation protection (less than or equal to 10 cGy) is currently lacking. It is therefore important to characterize early and subsequent in vivo biological response induced by low doses of ionizing radiation because such data should provide information that can help determine whether radiation at this dose level

164

Low Dose Radiation Research Program: John Minna  

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Minna University of Texas, Southwestern Medical Center John Minna, M.D. Currently Funded Projects Human Lung Cancer Progression Model for HZE Particle Exposure...

165

Low Dose Radiation Program: Links - Organizations Funding Radiation...  

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Funding Radiation Research Australian Radiation Protection and Nuclear Safety Agency Canadian Nuclear Safety Commission Centers for Medical Countermeasures Against Radiological and...

166

Low Dose Radiation Research Program: Transgenerational Effects...  

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Transgenerational Effects of Chronic Low-Dose Irradiation in a Medaka Fish Model System Colorado State University Why this Project? There are major gaps in our knowledge about...

167

Low Dose Radiation Research Program: Research Highlights  

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energy, are the surrounding unirradiated cells also at an increased risk of cancer? Latest Research, Response to Fukushima, Integrating Low Dose into Policy-All Featured at...

168

Low Dose Radiation Cancer Risks: Epidemiological and Toxicological Models  

Science Conference Proceedings (OSTI)

The basic purpose of this one year research grant was to extend the two stage clonal expansion model (TSCE) of carcinogenesis to exposures other than the usual single acute exposure. The two-stage clonal expansion model of carcinogenesis incorporates the biological process of carcinogenesis, which involves two mutations and the clonal proliferation of the intermediate cells, in a stochastic, mathematical way. The current TSCE model serves a general purpose of acute exposure models but requires numerical computation of both the survival and hazard functions. The primary objective of this research project was to develop the analytical expressions for the survival function and the hazard function of the occurrence of the first cancer cell for acute, continuous and multiple exposure cases within the framework of the piece-wise constant parameter two-stage clonal expansion model of carcinogenesis. For acute exposure and multiple exposures of acute series, it is either only allowed to have the first mutation rate vary with the dose, or to have all the parameters be dose dependent; for multiple exposures of continuous exposures, all the parameters are allowed to vary with the dose. With these analytical functions, it becomes easy to evaluate the risks of cancer and allows one to deal with the various exposure patterns in cancer risk assessment. A second objective was to apply the TSCE model with varing continuous exposures from the cancer studies of inhaled plutonium in beagle dogs. Using step functions to estimate the retention functions of the pulmonary exposure of plutonium the multiple exposure versions of the TSCE model was to be used to estimate the beagle dog lung cancer risks. The mathematical equations of the multiple exposure versions of the TSCE model were developed. A draft manuscript which is attached provides the results of this mathematical work. The application work using the beagle dog data from plutonium exposure has not been completed due to the fact that the research project did not continue beyond its first year.

David G. Hoel, PhD

2012-04-19T23:59:59.000Z

169

Environmental radiation dose criteria and assessment: pathway modeling and surveillance  

SciTech Connect

From nuclear science symposium; San Francisco, California, USA (14 Nov 1973). The controversy in recent years over the extent of the risk to the public from environmental radioactivity attributable to nuclear facilities (in particular nuclear power plants and fuel reprocessing facilities) has resulted in a lowering of previously acceptable environmental radiation levels. The proposal by the AEC to limit effluents from light-water-cooled nuclear reactors so that the exposure of any individual in the public would not exceed 5 mR/yr, and the pronouncement by the BEIR Committee that the current environmental radiation protection guides are unnecessarily high, are illustrative. In turn the AEC has issued a Safety Guide calling for considerable refinement in the measuring and reporting of effluents from nuclear power plants, and has only recently issued a counterpart dealing with the measuring and reporting of radioactivity in the environs of nuclear power plants. The EPA has also recently issued a guide for the surveillance of environmental radioactivity. Currently, power reactor operators are being required by the AEC Regulatory Staff to conduct detailed, sensitive environmental surveillance. Much of this appears to be based on extremely conservative assumptions throughout, including doseeffect relationships, exposure situations, pathway models, reconcentration factors and intakes, which cannot be substantiated when examined in the light of current experience in the vicinity of existing power reactors. The expenditures occasioned by the required additional in-plant features necessary to meet the currently proposed effluent release criteria appear difficult to justify on a reasonable basis. Environmental monitoring at the proposed concentration limits appear even more excessive in terms of dollars per man-rem of potential dose commitment. (auth)

Hull, A.P.

1973-01-01T23:59:59.000Z

170

ORISE: U.S. Nuclear Regulatory Commission Radiation Exposure Information  

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Information and Reporting System (REIRS) Information and Reporting System (REIRS) ORISE maintains large database of radiation exposure records for the U.S. Nuclear Regulatory Commission U.S. Nuclear Regulatory Commission Radiation Exposure Information and Reporting System (REIRS) The U.S. Nuclear Regulatory Commission (NRC) is required by federal mandate to maintain and evaluate radiation protection data for workers at facilities that it licenses. As part of its mission of safety, the NRC operates the Radiation Exposure Information and Reporting System (REIRS), a database system containing all occupational radiation exposure records that have been submitted to the NRC under 10 CFR Part 20. REIRS encompasses 1,800-plus NRC licensees and contains more than five million records for more than one million monitored individuals.

171

Radiation Leukemogenesis: Applying Basic Science of Epidemiological Estimates of Low Dose Risks and Dose-Rate Effects  

SciTech Connect

The next stage of work has been to examine more closely the A-bomb leukemia data which provides the underpinnings of the risk estimation of CML in the above mentioned manuscript. The paper by Hoel and Li (Health Physics 75:241-50) shows how the linear-quadratic model has basic non-linearities at the low dose region for the leukemias including CML. Pierce et. al., (Radiation Research 123:275-84) have developed distributions for the uncertainty in the estimated exposures of the A-bomb cohort. Kellerer, et. al., (Radiation and Environmental Biophysics 36:73-83) has further considered possible errors in the estimated neutron values and with changing RBE values with dose and has hypothesized that the tumor response due to gamma may not be linear. We have incorporated his neutron model and have constricted new A-bomb doses based on his model adjustments. The Hoel and Li dose response analysis has also been applied using the Kellerer neutron dose adjustments for the leukemias. Finally, both Pierce's dose uncertainties and Kellerer neutron adjustments are combined as well as the varying RBE with dose as suggested by Rossi and Zaider and used for leukemia dose-response analysis. First the results of Hoel and Li showing a significantly improved fit of the linear-quadratic dose response by the inclusion of a threshold (i.e. low-dose nonlinearity) persisted. This work has been complete for both solid tumor as well as leukemia for both mortality as well as incidence data. The results are given in the manuscript described below which has been submitted to Health Physics.

Hoel, D. G.

1998-11-01T23:59:59.000Z

172

Estimated effective dose rates from radon exposure in workplaces and residences within Los Alamos county in New Mexico  

SciTech Connect

Many millions of office workers are exposed to radon while at work and at home. Though there has been a multitude of studies reporting the measurements of radon concentrations and potential lung and effective doses associated with radon and progeny exposure in homes, similar studies on the concentrations and subsequent effective dose rates in the workplace are lacking. The purposes of this study were to measure radon concentrations in office and residential spaces in the same county and explore the radiation dose implications. Sixty-five track-etch detectors were deployed in office spaces and 47 were deployed in residences, all within Los Alamos County, New Mexico, USA. The sampling periods for these measurements were generally about three months. The measured concentrations were then used to calculate and compare effective dose rates resulting from exposure while at work and at home. Results showed that full-time office workers receive on average about nine times greater exposure at home than while in the office (691 mrem yr{sup -1} versus 78 mrem yr{sup -1}). The estimated effective dose rate for a more homebound person was 896 mrem yr{sup -1}. These effective dose rates are contrasted against the 100 mrem yr{sup -1} threshold for regulation of a 'radiological worker' defined in the Department of Energy regulations occupational exposure and the 10 mrem yr{sup -1} air pathway effective public dose limit regulated by the Environmental Protection Agency.

Whicker, Jeffrey J [Los Alamos National Laboratory; Mcnaughton, Michael [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

173

Low Dose Radiation Program: Principal Program Contacts  

NLE Websites -- All DOE Office Websites (Extended Search)

to the Office of Biological and Environmental Research. Dr. Barcellos-Hoff's current research interests are studies of breast cancer and ionizing radiation. The goal of her...

174

Low Dose Radiation Research Program: Charles Limoli  

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Radiation Biology, University of California, Irvine Funded Project Radiobiology of Neural Cancer Stem Cells Publications Elmore, E., Lao, X.Y., Kapadia, R., Giedzinski, E., Limoli,...

175

Low Dose Radiation Research Program: Characterizing Bystander...  

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To order to investigate these variables for low-linear transfer (LET) radiation, an electron microbeam irradiation system has been developed. An electron source provides a beam...

176

Low Dose Radiation Research Program: Alec Moreley  

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Alec Moreley Technical Abstracts 1999 Workshop: Development of PCR-Based Methods for the Detection of Mutagenic Effects of Ionizing Radiation Morley, A., Turner, D., and Sykes, P....

177

Mammalian Tissue Response to Low Dose Ionizing Radiation: The Role of Oxidative Metabolism and Intercellular Communication  

SciTech Connect

The objective of the project was to elucidate the mechanisms underlying the biological effects of low dose/low dose rate ionizing radiation in organs/tissues of irradiated mice that differ in their susceptibility to ionizing radiation, and in human cells grown under conditions that mimic the natural in vivo environment. The focus was on the effects of sparsely ionizing cesium-137 gamma rays and the role of oxidative metabolism and intercellular communication in these effects. Four Specific Aims were proposed. The integrated outcome of the experiments performed to investigate these aims has been significant towards developing a scientific basis to more accurately estimate human health risks from exposures to low doses ionizing radiation. By understanding the biochemical and molecular changes induced by low dose radiation, several novel markers associated with mitochondrial functions were identified, which has opened new avenues to investigate metabolic processes that may be affected by such exposure. In particular, a sensitive biomarker that is differentially modulated by low and high dose gamma rays was discovered.

Azzam, Edouard I

2013-01-16T23:59:59.000Z

178

Occupational Radiation Exposure at Commercial Nuclear Power Reactors and Other Facilities 2008  

Science Conference Proceedings (OSTI)

This report summarizes the occupational exposure data that are maintained in the U.S. Nuclear Regulatory Commission (NRC) Radiation Exposure Information and Reporting System (REIRS). The bulk of the information contained in the report was compiled from the 2008 annual reports submitted by five of the seven categories1 of NRC licensees subject to the reporting requirements of 10 CFR 20.2206. The annual reports submitted by these licensees consist of radiation exposure records for each monitored individual. These records are analyzed for trends and presented in this report in terms of collective dose and the distribution of dose among the monitored individuals. Because there are no geologic repositories for high-level waste currently licensed and no low-level waste disposal facilities in operation, only five categories will be considered in this report.

U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research

2009-12-01T23:59:59.000Z

179

Low Dose Radiation Research Program: Antone (Tony) L. Brooks  

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A.L. and Couch, L.A. 2002 Workshop: Optimizing the Scientific, Regulatory and Social Impact of the DOE Low Dose Radiation Research Program Brooks, A.L., Bull, R.J., and...

180

Low Dose Radiation Research Program: John S. Wassom  

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the Science of the Low Dose Radiation Research Program. Wassom, J.S., Owens, E.T., Martin, S.A., Wolfe, A.K., Lyday, M.K., and Dimmick, S.L. 2001 Workshop: Communicating the...

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181

Low Dose Radiation Research Program: Chaun-Yuan Li  

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Chaun-Yuan Li Chaun-Yuan Li Radiation Biology Research, Duke University Medical Center Funded Projects Molecular Characterization of the Role of SOD Genes in Mammalian Cellular Response to Low Dose Ionizing, abstract, description. Technical Abstracts 2006 Workshop: The Roles of Superoxide Dismutage (SOD) in Low Dose Radiation Induced Adaptive Response Yang, Z., Chuang, E., Batinic-Haberle, I., and Li, C.-Y. 2005 Workshop: Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Li, C.-Y., Guo, Z., Yang, Z., and Chuang, E. 2003 Workshop: Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Li, C.-Y. and Chuang, E. Publications Li, F., Sonveaux, P., Rabbani, Z.N., Liu, S., Yan, B., Huang, Q.,

182

Low Dose Radiation Research Program: Research Highlights - Health Physics  

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Health Physics Special Issue Features Contributions by Low Dose Health Physics Special Issue Features Contributions by Low Dose Investigators Health Physics The March 2011 special issue of Health Physics highlights the Victor Bond Workshop held May 2-5, 2010, in Richland, Wash. The workshop honored the late Dr. Victor (Vic) Bond for his lifetime achievement in the radiation sciences. Dr. Bond's research resulted in numerous influential scientific papers that contributed greatly to the understanding of radiation effects in biological systems. The workshop attracted internationally recognized experts in biophysics, experimental radiation biology, epidemiology, and risk assessment to discuss issues of low-dose risk. Participants included current and previously funded U.S. Department of Energy Low Dose Radiation Research

183

Low Dose Radiation Research Program: Genetic Variation in Tissue...  

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Genetic Variation in Tissue Responses to Low-Dose Radiation Authors: E. M. Rinchik,1,2 P. Hoyt,3 L. Branstetter,1 R. Olszewski,1 K. T. Cain,1 and B. Voy1,3 Institutions: 1Life...

184

Low Dose Radiation Research Program: The Characterization of...  

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The Characterization of Genetic Responses to Low Dose Radiation using a Genome-Wide Insertional Mutagenesis Approach Authors: Katherine A Vallis,1,2,3 William L Stanford,4 Zhuo...

185

Low Dose Radiation Research Program: Comparison of DNA Damage...  

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Comparison of DNA Damage Risk from Low-Dose Radiation and Folate Deficiency Arnold C. Huang,1,2 Chantal Courtemanche,1,2 Nicole Kerry,1,2 Susan T. Mashiyama,1,2 Michael Fenech,3...

186

Low Dose Radiation Research Program: Mechanistic Modeling of...  

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Laboratory Why This Project? Cells that are directly exposed to low doses of ionizing radiation may experience DNA damage. Cells which happen to be in the vicinity of the exposed...

187

Low Dose Radiation Research Program: 2011 Calendar of Upcoming...  

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Ann. Mtg. of the American Roentgen Ray Society, Chicago, IL, USA. May 9-11, 2011 Low Dose Radiation Research Investigators' Workshop, Bethesda, MD, USA. May 16-20, 2011...

188

Low Dose Radiation Research Program: Are Animals Heterozygous...  

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lymphocytes from animals of known genotypes. Radiation-induced foci occur in a time and dose dependent manner in the nuclei of normal cells, NBS cells on the other hand, do not...

189

Low Dose Radiation-Induced Epigenetic Alterations Found in Agouti...  

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Low Dose Radiation-Induced Epigenetic Alterations Found in Agouti Mouse Model Autumn Bernal Autumn Bernal Randy Jirtle Randy Jirtle In a paper published in The FASEB Journal, Low...

190

Low Dose Radiation Research Program: The Characterization of...  

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acts as a tag for identification of the gene, by cloning the fusion mRNA and using RT-PCR techniques. We have conducted such a screen using moderate dose radiation (2 to 4 Gy,...

191

Low Dose Radiation Research Program: Earlier Events  

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Earlier Events Earlier Events 2000 | 2001 | 2002 | 2003 | 2004 April 2000 Ionizing Radiation Science and Protection in the 21st Century, NCRP, April 5-6, Arlington, VA. RADIATION RESEARCH 2000, Association for Radiation Research, April 10-12, Bristol, UK. Florida Chapter of the Health Physics Society Spring 2000 Meeting, Gainesville, FL, April 13-14. 47th Annual Meeting of the Radiation Research Society, April 29-May 3, Albuquerque, NM. May 2000 IRPA-10 International Congress 2000, May 14-19, Hiroshima, Japan. IRPA-10 Secretariat, c/o Japan Convention Services, Inc., Nippon Press Center Building, 2-2-1, Uchisaiwai-cho, Chiyoda-ku, Tokyo 100, Japan. Phone: 81-3-3508-1214. Fax: 81-3-3508-0820. irpa10@convention.jp. 4th International Non-Ionizing Radiation Workshop, May 22-25, Kyoto,

192

Low Dose Radiation Research Program: Michael Weil  

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Dubrova, Y., Weil, M., and Brenner, D. H2AX Foci after Low Dose-Rate Irradiation Reveal a Defect in DNA DSB Processing in Cells from Unaffected Parents of...

193

Low Dose Radiation Research Program: Mina Bissell  

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Abstracts 2006 Workshop: 3D Tissue Models for the Study of the Effects of Low-Dose Irradiation Nelson, C.M., Fata, J E., Kenny, P.A., and Bissell, M.J. Publications Kumari, I.,...

194

Low Dose Radiation Research Program: David Nelson  

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L.E., Nelson, D., Sorensen, K., Tucker, J.D., and Wyrobek, A.J. (2005). Low-dose irradiation alters the transcript profiles of human lymphoblasoid cells, including genes...

195

Low Dose Radiation Research Program: Genetic Factors Affecting  

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Genetic Factors Affecting Susceptibility to Low-Doses of Ionizing Genetic Factors Affecting Susceptibility to Low-Doses of Ionizing Radiation. Authors: William F. Morgan, Pat Concannon & John H.J. Petrini The goal of this program is to test the hypothesis that mice heterozygous for the NBS1 gene are genetically susceptible to low doses of ionizing radiation. Patients with Nijmegen Breakage Syndrome (NBS) are radiation sensitive, because of defects in cellular responses to radiation induced genetic damage. It is unclear whether humans heterozygous for the mutations associated with NBS are radiation sensitive and results from cell culture experiments give conflicting results. In collaboration with John Petrini at the Memorial Sloan Kettering Cancer Center in New York City we developed a mouse model of this disorder and are directly testing the hypothesis

196

A Low-Dose Ipsilateral Lung Restriction Improves 3-D Conformal Planning for Partial Breast Radiation Therapy  

Science Conference Proceedings (OSTI)

In trials of 3D conformal external beam partial breast radiotherapy (PBRT), the dosimetrist must balance the priorities of achieving high conformity to the target versus minimizing low-dose exposure to the normal structures. This study highlights the caveat that in the absence of a low-dose lung restriction, the use of relatively en-face fields may meet trial-defined requirements but expose the ipsilateral lung to unnecessary low-dose radiation. Adding a low-dose restriction that {dose resulted in successful plans in 88% of cases. This low-dose lung limit should be used in PBRT planning.

Mitchell, Tracy [Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, University of Victoria, Victoria, British Columbia (Canada); Truong, Pauline T., E-mail: ptruong@bccancer.bc.c [Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, University of Victoria, Victoria, British Columbia (Canada); Salter, Lee; Graham, Cathy; Gaffney, Helene; Beckham, Wayne; Olivotto, Ivo A. [Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, University of Victoria, Victoria, British Columbia (Canada)

2011-04-01T23:59:59.000Z

197

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

exposure to radioactive fallout in Radiation-Associated inIslanders, who were exposed to fallout H-bomb test explosion

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

198

What can be learned from epidemiologic studies of persons exposed to low doses of radiation?  

SciTech Connect

The main objective of radiation risk assessment is to determine the risk of various adverse health effects associated with exposure to low doses and low dose rates. Extrapolation of risks from studies of persons exposed at high doses (generally exceeding 1 Sv) and dose rates has been the primary approach used to achieve this objective. The study of Japanese atomic bomb survivors in Hiroshima and Nagasaki has played an especially important role in risk assessment efforts. A direct assessment of the dose-response function based on studies of persons exposed at low doses and dose rates is obviously desirable. This paper focuses on the potential of both current and future nuclear workers studies for investigating the dose-response functions at low doses, and also discusses analyses making use of the low dose portion of the atomic bomb survivor data. Difficulties in using these data are the statistical imprecision of estimated dose-response parameters, and potential bias resulting from confounding factors and from uncertainties in dose estimates.

Gilbert, E.S.

1993-04-01T23:59:59.000Z

199

Low Dose Radiation Research Program: Melvyn Folkard  

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Melvyn Folkard Melvyn Folkard Gray Cancer Institute About this Project Currently Funded Projects A Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect Technical Abstracts 2005 Workshop: A Variable-Energy Soft X-Ray Microprobe to Investiage Mechanisms of the Radiation-Induced Bystander Effect Folkard, M., Vojnovic, B., Schettiono, G., Atkinson, K., Prise, K.M., Michael, B.D. 2003 Workshop: A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of the Radiation -Induced Bystander Effect. Folkard, M., Vojnovic, B., Schettino, G., Atkinson, K., Prise, K.M., Michael, B.D. 2002 Workshop: A Variable-Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect. Folkard, M., Vojnovic, B., Schettino,

200

Low Dose Radiation Research Program: Using a Low LET Electron Microbeam to  

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Using a Low LET Electron Microbeam to Investigate Non-Targeted Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation Authors: William F. Morgan1 and Marianne B. Sowa2 Institutions: 1Radiation Oncology Research Laboratory, University of Maryland, Baltimore, Maryland; 2Chemical Structure and Dynamics, Pacific Northwest National Laboratory, Richland Washington We have recently installed a low-linear energy transfer (LET) electron microbeam that generates energetic electrons to mimic radiation damage from gamma- and x-ray sources. It has been designed such that high-energy electrons deposit energy in a pre-selected subset of cells, leaving neighboring cells unirradiated (Figure 1). In this way it is possible to examine non-targeted effects associated with low dose radiation exposure,

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201

Low Dose Radiation Research Program: Role of TNF-α as a Potential  

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Role of TNF-α as a Potential Signaling Mediator of Role of TNF-α as a Potential Signaling Mediator of Radiation-Induced Bystander Effect in Human Vascular Cells. Authors: Mohan Natarajan, Sumathy Mohan, Catherine Gibbons, Yan Bo and Munira A. Kadhim Institutions: Departments of Radiation Oncology and Pathology, University of Texas Health Science Center, San Antonio, Texas; Environmental Toxicology Graduate Program, University of California, Riverside; Radiation and Genomic Stability Unit, Medical research Council, Oxford, United Kingdom Identifying reliable and sensitive signaling pathways that are implicated in adverse health effects after exposure to low doses of ionizing radiation would allow us to understand the scientific basis of low dose-induced signaling pathways and their downstream phenotypic expression. This

202

Low Dose Radiation Research Program: Wide Expression of LLIR and the  

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Wide Expression of LLIR and the Biological Consequences Wide Expression of LLIR and the Biological Consequences David J. Chen Lawrence Berkeley National Laboratory Why This Project It is known that changes in gene expression alter biological effects. It is necessary to identify the specific genes that demonstrate altered expression after exposure to low doses of ionizing radiation and to determine pathways involved in DNA damage recognition, signaling, and repair that are associated with radiation-induced adaptive and bystander effects. Project Goals Identification of genes whose transcription is regulated in response to low levels of ionizing radiation Identification of the genes and communication pathways that control these responses to low dose radiation Identification of the cellular and molecular targets that influence

203

Metabolomic Response of Human Skin Tissue to Low Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

Understanding how human organs respond to ionizing radiation (IR) at a systems biology level and identifying biomarkers for IR exposure at low doses can help provide a scientific basis for establishing radiation protection standards. Little is known regarding the physiological responses to low dose IR at the metabolite level, which represents the end-point of biochemical processes inside cells. Using a full thickness human skin tissue model and GC-MS-based metabolomics analysis, we examined the metabolic perturbations at three time points (3, 24 and 48 hr) after exposure to 3, 10 and 200 cGy of X-rays. PLS-DA score plots revealed dose- and time-dependent clustering between sham and irradiated groups. Importantly, a comparable number of metabolites were detected to have significant change 48 hr after exposure to 3 and 10 cGy of irradiation, when compared with the high dose of 200 cGy. Biochemical pathway analysis showed perturbations to DNA/RNA damage and repair, lipid and energy metabolisms, even at low doses of IR.

Hu, Zeping; Kim, Young-Mo; Sowa, Marianne B.; Robinson, Robert J.; Gao, Xiaoli; Metz, Thomas O.; Morgan, William F.; Zhang, Qibin

2012-05-18T23:59:59.000Z

204

Low Dose Radiation Program: Workshops, Proceedings, Abstracts and Programs  

NLE Websites -- All DOE Office Websites (Extended Search)

Workshops, Proceedings, Abstracts and Programs Workshops, Proceedings, Abstracts and Programs UPDATE: Investigators' Workshop Postponed The annual Low Dose Radiation Research Program Investigators' Workshop typically held in April or May has been postponed until next year. Please keep checking the website for updates. 2010 The 2010 DOE Low Dose Radiation Research Investigators' Workshop was held April 12-14, 2010, at the Renaissance M Street Hotel in Washington, D.C. In addition to 34 plenary talks and more than 70 poster presentations made by the program investigators, participants heard guest speakers from the National Cancer Institute and from sister low-dose programs in Europe and Japan. See link for investigators' abstracts. 2009 The DOE Low Dose Radiation Research Investigators' Workshop VIII was held

205

Low Dose Radiation Program: Links - Research Societies with Radiation...  

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Societies with Radiation Concerns Academy of Radiology Research American Association of Physicists in Medicine American Nuclear Society American Roentgen Ray Society American...

206

Errors and Uncertainties in Dose Reconstruction for Radiation Effects Research  

SciTech Connect

Dose reconstruction for studies of the health effects of ionizing radiation have been carried out for many decades. Major studies have included Japanese bomb survivors, atomic veterans, downwinders of the Nevada Test Site and Hanford, underground uranium miners, and populations of nuclear workers. For such studies to be credible, significant effort must be put into applying the best science to reconstructing unbiased absorbed doses to tissues and organs as a function of time. In many cases, more and more sophisticated dose reconstruction methods have been developed as studies progressed. For the example of the Japanese bomb survivors, the dose surrogate distance from the hypocenter was replaced by slant range, and then by TD65 doses, DS86 doses, and more recently DS02 doses. Over the years, it has become increasingly clear that an equal level of effort must be expended on the quantitative assessment of uncertainty in such doses, and to reducing and managing uncertainty. In this context, this paper reviews difficulties in terminology, explores the nature of Berkson and classical uncertainties in dose reconstruction through examples, and proposes a path forward for Joint Coordinating Committee for Radiation Effects Research (JCCRER) Project 2.4 that requires a reasonably small level of effort for DOSES-2008.

Strom, Daniel J.

2008-04-14T23:59:59.000Z

207

Low dose radiation combines with the Src oncoprotein to transform  

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radiation combines with the Src oncoprotein to transform radiation combines with the Src oncoprotein to transform pre-malignant human breast cells Paul Yaswen Lawrence Berkeley National Laboratory Abstract Goal: Determine whether low dose radiation exerts persistent epigenetic effects that promote malignancy. Background and Significance: Some persistent carcinogenic effects of radiation may not be traceable to specific DNA sequence alterations and may not be linearly related to dose. Through the biochemical initiation of positive feedback loops, ionization-induced events may have heritable non-linear effects on cellular behavior. Inflammatory responses involving the transcription factor NFκB may be subject to such effects. Increased NFκB activity has been strongly linked to carcinogenesis in a number of published in vitro and in vivo studies (reviewed in [1]). Since radiation

208

Low Dose Radiation Research Program: What's New Archive  

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What's New What's New Tony Brooks Chosen As Lauriston S. Taylor Lecturer Congratulations to radiation biologist Dr. Antone "Tony" Brooks, a consultant to the Pacific Northwest National Laboratory's Low Dose Radiation Research Program, on his selection to give the 36th Lauriston S. Taylor Lecture at the Annual Meeting of the National Council on Radiation Protection and Measurements (NCRP). Brooks is former chief scientist for the U.S. Department of Energy's Low Dose Radiation Research Program. His lecture, titled "From the Field to the Laboratory and Back: The What Ifs, Wows, and Who Cares of Radiation Biology," will be a featured presentation at the meeting, which will be held March 12 and 13, 2012, at the Hyatt Regency Bethesda, Bethesda, Maryland.

209

Low Dose Radiation Research Program: Low Dose Response of Respiratory Cells  

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Low Dose Radiation Research Program: Low Dose Response of Respiratory Low Dose Radiation Research Program: Low Dose Response of Respiratory Cells in Intact Tissues and Reconstituted Tissue Constructs Authors: John Ford, Amy Maslowski, Alex Redd and Les Braby Institutions: Texas A&M University, College Station, TX We are developing a model of respiratory tissue using a perfusion culture system. We are using this system to quantify the effects of normal tissue architecture, and the interaction of epithelial cells with other cell types, on radiation-induced bystander effects. Tracheal tissue taken from young adult Fischer 344 rats is imbedded in a growth factor enriched agarose matrix. The chamber is designed to allow growth medium to periodically wash the epithelial surface of the tracheal lumen while maintaining the air-interface that is necessary for the normal

210

Th Cell Gene Expression and Function in Response to Low Dose and Acute Radiation  

SciTech Connect

FINAL TECHNICAL REPORT Supported by the Low Dose Radiation Research Program, Office of Science U.S. Department of Energy Grant No. DE-FG02-07ER64345 Project ID: 0012965 Award Register#: ER64345 Project Manager: Noelle F. Metting, Sc.D. Phone: 301-903-8309 Division SC-23.2 noelle.metting@science.doe.gov Submitted March 2012 To: https://www.osti.gov/elink/241.3.jsp Title: Th Cell Gene Expression and Function in Response to Low Dose and Acute Radiation PI: Daila S. Gridley, Ph.D. Human low dose radiation data have been derived primarily from studies of space and airline flight personnel, nuclear plant workers and others exposed occupationally, as well as victims in the vicinity of atomic bomb explosions. The findings remain inconclusive due to population inconsistencies and complex interactions among total dose, dose rate, radiation quality and age at exposure. Thus, safe limits for low dose occupational irradiation are currently based on data obtained with doses far exceeding the levels expected for the general population and health risks have been largely extrapolated using the linear-nonthreshold dose-response model. The overall working hypothesis of the present study is that priming with low dose, low-linear energy transfer (LET) radiation can ameliorate the response to acute high-dose radiation exposure. We also propose that the efficacy of low-dose induced protection will be dependent upon the form and regimen of the high-dose exposure: photons versus protons versus simulated solar particle event protons (sSPE). The emphasis has been on gene expression and function of CD4+ T helper (Th) lymphocytes harvested from spleens of whole-body irradiated C57BL/6 mice, a strain that provides the genetic background for many genetically engineered strains. Evaluations of the responses of other selected cells, tissues such as skin, and organs such as lung, liver and brain were also initiated (partially funded by other sources). The long-term goal is to provide information that will be useful in estimating human health risks due to radiation that may occur during exposures in the work environment, nuclear/radiological catastrophes, as well as radiotherapy. Several papers have been published, accepted for publication or are in preparation. A number of poster and oral presentations have been made at scientific conferences and workshops. Archived tissues of various types will continue to be evaluated via funding from other sources (the DoE Low Dose Radiation Research Program, Office of Science and this specific grant will be appropriately included in the Acknowledgements of all subsequent publications/presentations). A post-doc and several students have participated in this study. More detailed description of the accomplishments is described in attached file.

Daila S. Gridley, PhD

2012-03-30T23:59:59.000Z

211

Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Application to p53 and Low Dose Ionizing Radiation.  

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Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Application to p53 and Low Dose Ionizing Radiation. Krassimira Botcheva, John J. Dunn and Carl W. Anderson Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA The effects of exposure to low doses of ionizing radiation on humans results largely from changes in gene expression mediated by the activation of sequence-specific DNA binding proteins (transcription factors) as well as changes to other chromosomal proteins and perhaps to DNA. To develop a molecular understanding of the consequences of exposures to low doses of ionizing radiation, it will be necessary to understanding where radiation-activated transcription factors bind in whole genomes and how

212

Systematic measurements of whole-body imaging dose distributions in image-guided radiation therapy  

Science Conference Proceedings (OSTI)

Purpose: The full benefit of the increased precision of contemporary treatment techniques can only be exploited if the accuracy of the patient positioning is guaranteed. Therefore, more and more imaging modalities are used in the process of the patient setup in clinical routine of radiation therapy. The improved accuracy in patient positioning, however, results in additional dose contributions to the integral patient dose. To quantify this, absorbed dose measurements from typical imaging procedures involved in an image-guided radiation therapy treatment were measured in an anthropomorphic phantom for a complete course of treatment. The experimental setup, including the measurement positions in the phantom, was exactly the same as in a preceding study of radiotherapy stray dose measurements. This allows a direct combination of imaging dose distributions with the therapy dose distribution. Methods: Individually calibrated thermoluminescent dosimeters were used to measure absorbed dose in an anthropomorphic phantom at 184 locations. The dose distributions from imaging devices used with treatment machines from the manufacturers Accuray, Elekta, Siemens, and Varian and from computed tomography scanners from GE Healthcare were determined and the resulting effective dose was calculated. The list of investigated imaging techniques consisted of cone beam computed tomography (kilo- and megavoltage), megavoltage fan beam computed tomography, kilo- and megavoltage planar imaging, planning computed tomography with and without gating methods and planar scout views. Results: A conventional 3D planning CT resulted in an effective dose additional to the treatment stray dose of less than 1 mSv outside of the treated volume, whereas a 4D planning CT resulted in a 10 times larger dose. For a daily setup of the patient with two planar kilovoltage images or with a fan beam CT at the TomoTherapy unit, an additional effective dose outside of the treated volume of less than 0.4 mSv and 1.4 mSv was measured, respectively. Using kilovoltage or megavoltage radiation to obtain cone beam computed tomography scans led to an additional dose of 8-46 mSv. For treatment verification images performed once per week using double exposure technique, an additional effective dose of up to 18 mSv was measured. Conclusions: Daily setup imaging using kilovoltage planar images or TomoTherapy megavoltage fan beam CT imaging can be used as a standard procedure in clinical routine. Daily kilovoltage and megavoltage cone beam computed tomography setup imaging should be applied on an individual or indication based protocol. Depending on the imaging scheme applied, image-guided radiation therapy can be administered without increasing the dose outside of the treated volume compared to therapies without image guidance.

Haelg, Roger A.; Besserer, Juergen; Schneider, Uwe [Radiotherapie Hirslanden AG, Institute for Radiotherapy, Aarau 5000 (Switzerland); Vetsuisse Faculty, University of Zurich, Zurich 8057 (Switzerland) and Radiotherapie Hirslanden AG, Institute for Radiotherapy, Aarau 5000 (Switzerland)

2012-12-15T23:59:59.000Z

213

Cellular response to low dose radiation: Role of phosphatidylinositol-3 kinase like kinases  

Science Conference Proceedings (OSTI)

It is increasingly realized that human exposure either to an acute low dose or multiple chronic low doses of low LET radiation has the potential to cause different types of cancer. Therefore, the central theme of research for DOE and NASA is focused on understanding the molecular mechanisms and pathways responsible for the cellular response to low dose radiation which would not only improve the accuracy of estimating health risks but also help in the development of predictive assays for low dose radiation risks associated with tissue degeneration and cancer. The working hypothesis for this proposal is that the cellular mechanisms in terms of DNA damage signaling, repair and cell cycle checkpoint regulation are different for low and high doses of low LET radiation and that the mode of action of phosphatidylinositol-3 kinase like kinases (PIKK: ATM, ATR and DNA-PK) determines the dose dependent cellular responses. The hypothesis will be tested at two levels: (I) Evaluation of the role of ATM, ATR and DNA-PK in cellular response to low and high doses of low LET radiation in simple in vitro human cell systems and (II) Determination of radiation responses in complex cell microenvironments such as human EpiDerm tissue constructs. Cellular responses to low and high doses of low LET radiation will be assessed from the view points of DNA damage signaling, DNA double strand break repair and cell cycle checkpoint regulation by analyzing the activities (i.e. post-translational modifications and kinetics of protein-protein interactions) of the key target proteins for PI-3 kinase like kinases both at the intra-cellular and molecular levels. The proteins chosen for this proposal are placed under three categories: (I) sensors/initiators include ATM ser1981, ATR, 53BP1, gamma-H2AX, MDC1, MRE11, Rad50 and Nbs1; (II) signal transducers include Chk1, Chk2, FANCD2 and SMC1; and (III) effectors include p53, CDC25A and CDC25C. The primary goal of this proposal is to elucidate the differences in cellular defense mechanisms between low and high doses of low LET radiation and to define the radiation doses where the cellular DNA damage signaling and repair mechanisms tend to shift. This information is critically important to address and advance some of the low dose research program objectives of DOE. The results of this proposed study will lead to a better understanding of the mechanisms for the cellular responses to low and high doses of low LET radiation. Further, systematic analysis of the role of PIKK signaling pathways as a function of radiation dose in tissue microenvironment will provide useful mechanistic information for improving the accuracy of radiation risk assessment for low doses. Knowledge of radiation responses in tissue microenvironment is important for the accurate prediction of ionizing radiation risks associated with cancer and tissue degeneration in humans.

Balajee, A.S.; Meador, J.A.; Su, Y.

2011-03-24T23:59:59.000Z

214

Molecular Mechanisms of Low Dose Radiation Mediated Hormesis in C. elegans  

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Mechanisms of Low Dose Radiation Mediated Hormesis in C. Mechanisms of Low Dose Radiation Mediated Hormesis in C. elegans Anders Olsen, Maithili C. Vantipalli, Arnold Kahn, Judith Campisi and Gordon J. Lithgow. Buck Institute for Age Research, 8001 Redwood Boulevard, Novato CA 94945 Brief exposure to a mild stress causes induction of stress gene expression leading to enhanced stress responses, improved maintenance and repair and in some cases lifespan increase. This phenomenon is termed hormesis and has been observed in several species. For example, we previously demonstrated that short periods of mild heat stress in early life increase both mean and maximum lifespan of the soil nematode C. elegans. Similar hormetic responses have been described for many other stressors. Here we present data showing that treatment of the nematode with low-doses of ionizing

215

Effective dose and several factors of its identification. (Assessment of radiation hazard in space flights)  

E-Print Network (OSTI)

Effective dose and several factors of its identification. (Assessment of radiation hazard in space flights)

Farber, Yu V; Grigoriev, Yu G; Tabakova, L A

1971-01-01T23:59:59.000Z

216

Low dose radiation hypersensitivity and clustered DNA damages in human fibroblasts exposed to low dose and dose rate protons or 137CS y-rays  

SciTech Connect

Effective radioprotection for human space travelers hinges upon understanding the individual properties of charged particles. A significant fraction of particle radiation astronauts will encounter in space exploratory missions will come from high energy protons in galactic cosmic radiation (GCR) and/or possible exposures to lower energy proton flux from solar particle events (SPEs). These potential exposures present major concerns for NASA and others, in planning and executing long term space exploratory missions. We recently reported cell survival and transformation (acquisition of anchorage-independent growth in soft agar) frequencies in apparently normal NFF-28 primary human fibroblasts exposed to 0-30 cGy of 50MeV, 100MeV (SPE-like), or 1000 MeV (GCR-like) monoenergetic protons. These were modeled after 1989 SPE energies at an SPE-like low dose-rate (LDR) of 1.65 cGy/min or high dose rate (HDR) of 33.3 cGy/min delivered at the NASA Space Radiation Laboratory (NSRL) at BNL.

Bennett P. V.; Bennett, P.V.; Keszenman, D.J.; Johnson, A.M.; Sutherland, B.M.; Wilson, P.F.

2013-05-14T23:59:59.000Z

217

Persistent DNA damage foci, cellular senescence and low dose radiation  

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Persistent DNA damage foci, cellular senescence and low dose radiation Persistent DNA damage foci, cellular senescence and low dose radiation Denise Munoz 1 , Albert Davalos 1 , Francis Rodier 1 , Misako Kawahara 1 , Judith Campisi 1,2 and Steven Yannone 1,3 1 Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 84-171, Berkeley CA 94720; 2 Buck Institute for Age Research, 8001 Redwood Boulevard, Novato CA 94945; 3 Corresponding author Ionizing radiation (IR) induced DNA double-strand breaks (DSBs) are cytologically detectable as large nuclear foci that contain phosphorylated histone H2AX (γH2AX), the adaptor protein 53BP1, and several other proteins that participate in the sensing and processing of DNA damage (DNA damage foci). In normal human cells, moderately high IR (0.5-1 Gy) doses cause the rapid appearance of these foci (acute DNA damage foci), which gradually disappear

218

Carcinogenesis and low-level ionizing radiation with special reference to lung cancer and exposure to radon daughters  

SciTech Connect

Of the important health effects of ionizing radiation, three important late effects - carcinogenesis, teratogenesis and mutagenesis are of greatest concern. This is because any exposure, even at low levels, carries some risk of such deleterious effects. As the dose of radiation increases above very low levels, the risk of health effects increases. Cancer-induction is the most important late somatic effect of low-dose ionizing radiation. Solid cancers, rather than leukemia, are principal late effects in exposed individuals. Tissues vary greatly in their susceptibility to radiation carcinogenesis. The most frequently occurring radiation-induced cancers in man include, in decreasing order of susceptibility: the female breast, the thyroid gland, the blood-forming tissues, the lung, certain organs of the gastrointestinal tract, and the bones. A number of biological and physical factors affect the cancer risk, such as age, sex, life-style, LET, and RBE. Despite uncertainty about low-level radiation risks, regulatory and advisory bodies must set standards for exposure, and individuals need information to be able to make informed judgments for themselves. From the point of view of the policy maker, the overriding concern is the fact that small doses of radiation can cause people to have more cancers than would otherwise be expected. While concern for all radiation effects exists, our human experience is limited to cancer-induction in exposed populations. This discussion is limited to cancer risk estimation and decision-making in relation to the health effects on populations of exposure to low levels of ionizing radiation. Here, low-level radiation will refer to yearly whole-body doses up to 5 rems or 0.05 Sv, or to cumulative doses up to 50 rems or 0.5 Sv from low-LET radiation and from high-LET radiation. (ERB)

Fabrikant, J.I.

1982-04-01T23:59:59.000Z

219

Low Dose Radiation Research Program: Frequencies of Radiation-Induced  

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Frequencies of Radiation-Induced Chromosome Interchanges and Frequencies of Radiation-Induced Chromosome Interchanges and Randomness of Chromosome Territory Locations Relative to One Another. Authors: RK Sachs,§ MN Cornforth,‡ KM Greulich-Bode,* L Hlatky, and DJ Brenner|| Institutions: §Department of Mathematics, University of California, ‡University of Texas Medical Branch, *Department of Skin Carcinogenesis, German Cancer Research Center DFCI, Harvard Medical School, ||Center for Radiological Research, Columbia University. Leukemogenesis, and perhaps carcinogenesis in general, often involves specific chromosome translocations. Radiation-induced chromosome translocation frequencies are strongly influenced by how close participating chromosomes are to one another in an interphase cell nucleus. We sought to determine whether chromosomes in human peripheral blood

220

Low Dose Radiation Research Program: Molecular Mechanisms of  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Mechanisms of Radiation-Induced Genomic Instability in Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells. Authors: Howard L. Liber1 and Jeffrey L. Schwartz2. Institutions: 1Colorado State University and 2University of Washington. Knowledge of the signal and target through which radiation induces genomic instability, which we propose to investigate herein, will allow us to model effects at low doses. Such knowledge will aid in understanding variations in the induction of this genomic instability, both among cells and among individuals. This information could also lead to more sensitive measures of instability that could yield accurate measures of instability induction at low doses. We have developed an in-vitro cell model, in which radiation-induced chromosome instability develops in a two-stage process.

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Dosimeter for measuring skin dose and more deeply penetrating radiation  

DOE Patents (OSTI)

A personnel dosimeter includes a plurality of compartments containing thermoluminescent dosimeter phosphors for registering radiation dose absorbed in the wearer's sensitive skin layer and for registering more deeply penetrating radiation. Two of the phosphor compartments communicate with thin windows of different thicknesses to obtain a ratio of shallowly penetrating radiation, e.g. beta. A third phosphor is disposed within a compartment communicating with a window of substantially greater thickness than the windows of the first two compartments for estimating the more deeply penetrating radiation dose. By selecting certain phosphors that are insensitive to neutrons and by loading the holder material with netruon-absorbing elements, energetic neutron dose can be estimated separately from other radiation dose. This invention also involves a method of injection molding of dosimeter holders with thin windows of consistent thickness at the corresponding compartments of different holders. This is achieved through use of a die insert having the thin window of precision thickness in place prior to the injection molding step.

Jones, Donald E. (Idaho Falls, ID); Parker, DeRay (Idaho Falls, ID); Boren, Paul R. (Idaho Falls, ID)

1981-01-01T23:59:59.000Z

222

Radiation exposure in X-ray-based imaging techniques used in osteoporosis  

E-Print Network (OSTI)

to low levels of ionizing radiation: BEIR VII Phase 2. TheBlake G, Genant HK (1999) Radiation exposure in bone mineralGuglielmi Thomas M. Link Radiation exposure in X-ray-based

Damilakis, John; Adams, Judith E.; Guglielmi, Giuseppe; Link, Thomas M.

2010-01-01T23:59:59.000Z

223

Reducing Stray Radiation Dose for a Pediatric Patient Receiving Proton Craniospinal Irradiation  

Science Conference Proceedings (OSTI)

Dose/Dose Rate / Special Issue on the 11th International Conference on Radiation Shielding and the 15th Topical Meeting of the Radiation Protection and Shielding Division (Part 1) / Radiation Protection

Phillip J. Taddei; Dragan Mirkovic; Jonas D. Fontenot; Annelise Giebeler; Yuanshui Zheng; Uwe Titt; Shiao Woo; Wayne D. Newhauser

224

Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/Low LET Ionizing Radiation  

SciTech Connect

Exposure to ionizing radiation results in the immediate formation of free radicals and other reactive oxygen species (ROS). It has been assumed that the subsequent injury processes leading to genomic instability and carcinogenesis following radiation, derive from the initial oxidative damage caused by these free radicals and ROS. It is now becoming increasingly obvious that metabolic oxidation/reduction (redox) reactions can be altered by irradiation leading to persistent increases in steady-state levels of intracellular free radicals and ROS that contribute to the long term biological effects of radiation exposure by causing chronic oxidative stress. The objective during the last period of support (DE-FG02-05ER64050; 5/15/05-12/31/09) was to determine the involvement of mitochondrial genetic defects in metabolic oxidative stress and the biological effects of low dose/low LET radiation. Aim 1 was to determine if cells with mutations in succinate dehydrogenase (SDH) subunits C and D (SDHC and SDHD in mitochondrial complex II) demonstrated increases in steady-state levels of reactive oxygen species (ROS; O2- and H2O2) as well as demonstrating increased sensitivity to low dose/low LET radiation (10 cGy) in cultured mammalian cells. Aim #2 was to determine if mitochondrially-derived ROS contributed to increased sensitivity to low dose/low LET radiation in mammalian cells containing mutations in SDH subunits. Aim #3 was to determine if a causal relationship existed between increases in mitochondrial ROS production, alterations in electron transport chain proteins, and genomic instability in the progeny of irradiated cells. Evidence gathered in the 2005-2009 period of support demonstrated that mutations in genes coding for mitochondrial electron transport chain proteins (ETC); either Succinate Dehydrogenase (SDH) subunit C (SDHC) or subunit D (SDHD); caused increased ROS production, increased genomic instability, and increased sensitivity to low dose/low LET radiation that could be mitigated by over expression of the H2O2 metabolizing enzyme, catalase, and/or the mitochondrial form of superoxide dismutase (MnSOD). Furthermore, using radiation-induced genomically unstable cells, it was shown that steady-state levels of H2O2 were significantly elevated for many cell generations following exposure, catalase suppressed the radiation-induced mutator phenotype when added long after radiation exposure, unstable clones showed evidence of mitochondrial dysfunction some of which was characterized by improper assembly of SDH subunits (particularly subunit B), and chemical inhibitors of SDH activity could decrease steady-state levels of H2O2 as well as mutation frequency. These results support the hypotheses that 1) SDH mutations could contribute to transformation by inducing genomic instability and a mutator phenotype via increasing steady-state levels of ROS; 2) metabolic sources of O2- and H2O2 play a significant role in low dose radiation induced injury and genomic instability; and 3) increased mutation rates in irradiated mammal cells can be suppressed by scavengers of H2O2 (particularly catalase) long after radiation exposure. Overall the results obtained during this period of support provide clear evidence in support of the hypothesis that abnormal oxidative metabolism in mitochondria that result in increases in steady-sate levels of H2O2 and other ROS are capable of significantly contributing to radiation-induced mutator phenotypes in mammalian cells.

Spitz, Douglas R.

2009-11-09T23:59:59.000Z

225

United States Department of Energy Low Dose Radiation Research Program  

NLE Websites -- All DOE Office Websites (Extended Search)

History of the History of the United States Department of Energy (DOE) Low Dose Radiation Research Program: 1998-2008 Dr. Antone L. Brooks tbrooks@tricity.wsu.edu September 2012 Review Draft i Contents Preface............................................................................................................................................. v Summary ........................................................................................................................................ vi Acronyms and Initialisms ............................................................................................................. vii Chapter 1 Introduction ................................................................................................................... 1

226

Low Dose Radiation Research Program: Optimizing the Scientific, Regulatory,  

NLE Websites -- All DOE Office Websites (Extended Search)

Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program Antone L. Brooks Why This Project? For maximum benefit, state-of-the-art research and new data from the Low Dose Radiation Research Program must be available to other scientists, regulatory agencies, and the public. This project stays abreast of scientific advances in the field, gathers, integrates, and summarizes the research within the program, and disseminates this information to appropriate scientific, regulatory, and public venues. Project Goals Provides a focal point for distribution of information generated in the program, to scientific committees, other governmental and regulatory agencies, and to the public Provides scientific support for the Low Dose Program website

227

Can radiation therapy treatment planning system accurately predict surface doses in postmastectomy radiation therapy patients?  

Science Conference Proceedings (OSTI)

Skin doses have been an important factor in the dose prescription for breast radiotherapy. Recent advances in radiotherapy treatment techniques, such as intensity-modulated radiation therapy (IMRT) and new treatment schemes such as hypofractionated breast therapy have made the precise determination of the surface dose necessary. Detailed information of the dose at various depths of the skin is also critical in designing new treatment strategies. The purpose of this work was to assess the accuracy of surface dose calculation by a clinically used treatment planning system and those measured by thermoluminescence dosimeters (TLDs) in a customized chest wall phantom. This study involved the construction of a chest wall phantom for skin dose assessment. Seven TLDs were distributed throughout each right chest wall phantom to give adequate representation of measured radiation doses. Point doses from the CMS Xio Registered-Sign treatment planning system (TPS) were calculated for each relevant TLD positions and results correlated. There were no significant difference between measured absorbed dose by TLD and calculated doses by the TPS (p > 0.05 (1-tailed). Dose accuracy of up to 2.21% was found. The deviations from the calculated absorbed doses were overall larger (3.4%) when wedges and bolus were used. 3D radiotherapy TPS is a useful and accurate tool to assess the accuracy of surface dose. Our studies have shown that radiation treatment accuracy expressed as a comparison between calculated doses (by TPS) and measured doses (by TLD dosimetry) can be accurately predicted for tangential treatment of the chest wall after mastectomy.

Wong, Sharon [National University of Singapore, Yong Loo Lin School of Medicine (Singapore); Back, Michael [Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, New South Wales (Australia); Tan, Poh Wee; Lee, Khai Mun; Baggarley, Shaun [National University, Cancer Institute, Department of Radiation Oncology, National University, Hospital, Tower Block (Singapore); Lu, Jaide Jay, E-mail: mdcljj@nus.edu.sg [National University of Singapore, Yong Loo Lin School of Medicine (Singapore); National University, Cancer Institute, Department of Radiation Oncology, National University, Hospital, Tower Block (Singapore)

2012-07-01T23:59:59.000Z

228

Image Quality and Radiation Dose Assessment of a Digital Mammography System  

Science Conference Proceedings (OSTI)

Image quality and radiation dose of a direct amorphous selenium digital mammography system were considered in terms of contrast to noise ratio (CNR) and average glandular dose (AGD). They were measured for various qualities and breast phantom thicknesses with different types of breast tissue composition to determine optimal radiation quality and dose. Three sets of breast tissue equivalent slabs (30%:70%, 50%:50% and 70%:30% glandular-adipose) with thickness of 2 cm to 7 cm and 0.2 mm aluminum foil were used to provide certain CNR. Two different combinations of anode/ilter material and a wide range of tube voltages were employed for each phantom thickness. Phantom images with grid were acquired using automatic exposure control (AEC) mode for each thickness. Phantom images without grid were also obtained in manual exposure mode by selecting the same anode/filter combination and kVp as the image obtained with grid at the same thickness, but varying mAs of 10 to 200 mAs. Optimization indicated that relatively high energy beam qualities should be used with a greater dose to compensate for lower energy x-rays. The results also indicate that current AEC setting for a fixed detector is not optimal.

Isa, N. M.; Hassan, W. M. S. W. [Department of Physics, Universiti Teknologi Malaysia, 81310 Skudai, Johor (Malaysia); Abdullah, W. A. K. W. [Department of Radiology, Hospital USM, 16150 Kubang Kerian, Kelantan (Malaysia); Othman, F. [Department of Diagnostic Imaging, Hospital Putrajaya, Pres, 62250 Putrajaya, Walayah Persekutuan (Malaysia); Ramli, A. A. M. [Malaysian Nuclear Agency, 43000 Kajang, Selangor (Malaysia)

2010-07-07T23:59:59.000Z

229

Reducing waste generation and radiation exposure by analytical method modification  

SciTech Connect

The primary goal of an analytical support laboratory has traditionally been to provide accurate data in a timely and cost effective fashion. Added to this goal is now the need to provide the same high quality data while generating as little waste as possible. At the Savannah River Technology Center (SRTC), we have modified and reengineered several methods to decrease generated waste and hence reduce radiation exposure. These method changes involved improving detection limits (which decreased the amount of sample required for analysis), decreasing reaction and analysis time, decreasing the size of experimental set-ups, recycling spent solvent and reagents, and replacing some methods. These changes had the additional benefits of reducing employee radiation exposure and exposure to hazardous chemicals. In all cases, the precision, accuracy, and detection limits were equal to or better than the replaced method. Most of the changes required little or no expenditure of funds. This paper describes these changes and discusses some of their applications.

Ekechukwu, A.A.

1996-10-01T23:59:59.000Z

230

Low Dose Radiation Research Program: Comparisons of IR and ROS for  

NLE Websites -- All DOE Office Websites (Extended Search)

Comparisons of IR and ROS for Induction of Damage to Cells Comparisons of IR and ROS for Induction of Damage to Cells Kathryn D. Held1, Yvonne L. McCarey1, Laurence Tartier1, Elena V. Rusyn1, Giuseppe Schettino2, Melvyn Folkard2, Kevin M. Prise2, and Barry D. Michael2 1Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114; 2Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, HA6 2JR, UK Accurate evaluation of the risks associated with exposure to low doses of ionizing radiation (IR) is a major challenge for environmental sciences. Studies on the mechanisms of the actions of low doses of IR are needed to help understand possible risks. IR exerts its effects on cells through production of reactive oxidizing species (ROS) such as ·OH, H2O2 and

231

The Association between Cancers and Low Level Radiation: an evaluation of the epidemiological evidence at the Hanford Nuclear Weapons Facility  

E-Print Network (OSTI)

date of death, internal radiation and exposure period, thedeath, death year, internal radiation, exposure period, andexposures (chemical and smoking), internal doses, and types of radiation.

Britton, Julie

2010-01-01T23:59:59.000Z

232

Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Non-Protein Thiols and Vitamin E.  

NLE Websites -- All DOE Office Websites (Extended Search)

Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Non-Protein Thiols and Vitamin E. J.S. Murley 1 , Y. Kataoka 1 , W.F. Morgan 2 , and D.J. Grdina 1 . The University of Chicago, Chicago, IL 1 , The University of Maryland Medical School, Baltimore, MD 2 Induced or delayed radioprotection is a novel phenomenon that shares many similarities with the low dose radiation-induced radiobiological phenomenon referred to as the adaptive response. Induced or delayed radioprotection is defined as an enhancement in the radiation resistance of cells at long times following their exposure to non-protein thiols (NPT) such as WR1065, the free thiol form of amifostine. This effect is the result of the induction of a cascade of intracellular

233

DOE Low Dose Radiation Research Workshop I November 1999  

NLE Websites -- All DOE Office Websites (Extended Search)

Low Dose Radiation Research Program Low Dose Radiation Research Program U.S. Department of Energy Office of Biological and Environmental Research David G. Thomassen, Ph.D. Program Coordinator Office of Biological and Environmental Research U.S. Department of Energy, SC-72 19901 Germantown Road Germantown, MD 20874-1290 Phone: 301-903-9817 Fax: 301-903-8521 Email: david.thomassen@science.doe.gov Arthur Katz, Ph.D. Life Sciences Division Office of Biological and Environmental Research U.S. Department of Energy, SC-72 19901 Germantown Road Germantown, MD 20874-1290 Phone: 301-903-4932 Fax: 301-903-8521 Email: arthur.katz@science.doe.gov Marvin E. Frazier, Ph.D. Director, Life Sciences Division Office of Biological and Environmental Research U.S. Department of Energy, SC-72 19901 Germantown Road

234

Low dose ionizing radiation induces tumor growth promoting factors in  

NLE Websites -- All DOE Office Websites (Extended Search)

ionizing radiation induces tumor growth promoting factors in ionizing radiation induces tumor growth promoting factors in stress-induced premature senescent fibroblasts David Boothman University of Texas Southwestern Medical Center at Dallas Abstract Recent evidence suggest that the causes of cancer development are not limited to mutations within cancer cells, but also involve in alterations of cancer microenvironment. Senescent cells are irreversibly growth arrested, but remain metabolically active. Senescent cells, especially senescent fibroblasts in the stroma may provide a beneficial environment for tumor growth through secretion of certain factors. Accumulation of senescent cells in the stroma of patients repeatedly exposed to low doses of IR or low dose rates of IR, could be an important factor, causing alteration of the microenvironment that ultimately benefits tumor

235

Low Dose Radiation Research Program: Optimizing the Scientific, Regulatory  

NLE Websites -- All DOE Office Websites (Extended Search)

Optimizing the Scientific, Regulatory and Social Impact of the DOE Optimizing the Scientific, Regulatory and Social Impact of the DOE Low Dose Radiation Research Program. Authors: Antone L.Brooks, Richard J. Bull, Lezlie A. Couch. Institutions: Washington State University Tri-Cities The purpose of this project is to provide scientific, technical, and organizational support to optimize the impact of the DOE Low Dose Radiation Research Program. This project will serve as a focal point for collection and dissemination of scientific information from the scientists funded in the Program to the U.S. Department of Energy (DOE), the regulatory agencies, and the public. The project will be responsible for analysis of the scientific information in the broader context of biomedical research and will provide this information to the Office of Biological Research

236

Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal  

NLE Websites -- All DOE Office Websites (Extended Search)

and HZE Particle Effects on Adult Hippocampal and HZE Particle Effects on Adult Hippocampal Neurogenesis and mRNA Expression Kerry O'Banion University of Rochester School of Medicine & Dentistry Abstract Most of our knowledge about low dose radiation effects relates to DNA damage and chromosomal aberrations that result in cell death or alterations in genetic programs leading to malignancy. In addition To direct DNA damage, there is accumulating evidence that radiation induced alterations in the microenvironment can have significant effects on programs of cell replication and differentiation such as neurogenesis in adult mammalian brain. Adult neurogenesis in the hippocampus is postulated to play an important role in learning and memory and manipulations that alter neurogenesis, including inhibition following radiation exposure, have been

237

Mechanisms underlying cellular responses of cells from haemopoeitic tissue to low dose-low LET radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

underlying cellular responses of cells from haemopoeitic underlying cellular responses of cells from haemopoeitic tissue to low dose-low LET radiation Munira Kadhim 1 , Sarah Irons 1 , Deborah Bowler 1 , Virginia Serra 1 , Stefania Militi 2 , Kim Chapman 1 1 Genomic Instability Research Group, School of Life Sciences, Oxford Brookes University, Gipsy Lane, Headington, Oxford, Oxfordshire, OX3 0BP, UK 2 Mammalian Genetics Unit, Medical Research Council Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK Radiation-induced responses at the cellular and whole body levels are influenced by genetic predisposition, with implications for environmental and potentially, diagnostic exposures. Currently, the extent to which genetic background play a role in the mechanisms and signalling pathways involved in radiation-induced

238

Low Dose Radiation Research Program: DNA Damage in Acutely Irradiated F2  

NLE Websites -- All DOE Office Websites (Extended Search)

DNA Damage in Acutely Irradiated F2 Mice with a History of Paternal DNA Damage in Acutely Irradiated F2 Mice with a History of Paternal F0 Germline Irradiation Authors: J.E. Baulch and O.G. Raabe Institutions: Center for Health and the Environment, University of California, Davis, CA. The main goal of this grant is to evaluate heritable, transgenerational effects of low dose, low-linear-energy-transfer (LET) radiation (0.1 Gy attenuated 137Cs gamma rays) on Type B spermatogonia in 129SVE mice; wild-type and heterozygous for Ataxia-telangiectasia (AT). The ATM heterozygotes are carriers for a genetic mutation (AT mutated, ATM) that is thought to predispose both humans and mice to radiation sensitivity. Experiments conducted in our laboratory have demonstrated heritable effects of paternal germline exposure to ionizing radiation in mice using 1.0 Gy of

239

Low Dose Radiation Research Program: Jian Jian Li  

NLE Websites -- All DOE Office Websites (Extended Search)

Jian Jian Li Jian Jian Li School of Health Sciences, Purdue University Newly Funded Projects Regulation of NF-kB and Mn SOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells, abstract, description. Technical Abstracts 2006 Workshops: NF-kB Mediated Signaling Network in Low Dose X-Ray Induced Adaptive Protection on Mouse and Human Skin Epithelial Cells Ahmed, K.M., Fan, M., Spitz, and Li, J.J. 2005 Workshops: Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1. Li, J.J., Ahmed, K.M., Fan, M., Dong, S., Spitz, D.R., and Yu, C.-R. 2003 Workshops: Gene Expression Profiles of Human Skin Keratinocytes Exposed to Acute and Chronic Ionizing Radiation Li, J.J., Ozeki, M., Wang, T., Tamae, D., Nelson, D., Wyrobek, A., and

240

Low Dose Radiation Research Program: Radiation-Induced Nuclear Factor kB  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation-Induced Nuclear Factor kB mediates survival advantage by Radiation-Induced Nuclear Factor kB mediates survival advantage by Telomerase Activation. Authors: Natarajan M.,1 Mohan S.,2 Pandeswara, S.L.,1 and Herman T.S.1 Institutions: Departments of 1Radiation Oncology and 2Pathology, The University of Texas Health Science Center, San Antonio, Texas Activation of NF-kB in response to low doses of ionizing radiation was first shown in our laboratory. Although studies have shown that NF-kB plays an important role in anti-apoptotic function, little has been done to understand the molecular link between the activation of NF-kB and cellular outcome such as enhanced cell survival after low dose low-linear transfer (LET) radiation. Because upregulation of telomerase activity is associated with longevity and allows cells to escape from senescence, we hypothesize

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241

Irradiators for measuring the biological effects of low dose-rate ionizing radiation fields  

E-Print Network (OSTI)

Biological response to ionizing radiation differs with radiation field. Particle type, energy spectrum, and dose-rate all affect biological response per unit dose. This thesis describes methods of spectral analysis, ...

Davidson, Matthew Allen

2011-01-01T23:59:59.000Z

242

Integrated beta and gamma radiation dose calculations for the ferrocyanide waste tanks  

SciTech Connect

This report contains the total integrated beta and gamma radiation doses in all the ferrocyanide waste tanks. It also contains estimated gamma radiation dose rates for all single-shell waste tanks containing a liquid observation well.

Parra, S.A.

1994-11-30T23:59:59.000Z

243

Activation of nuclear factor kB in human lymphoblastoid cells by low-dose ionizing radiation  

SciTech Connect

Nuclear factor kB (NF-kB) is a pleiotropic transcription factor which is involved in the transcriptional regulation of several specific genes. Recent reports demonstrated that ionizing radiation in the dose range of 2-50 Gy results in expression of NF-kB in human KG-1 myeloid leukemia cells and human B-lymphocyte precursor cells; the precise mechanism involved and the significance are not yet known. The present report demonstrates that even lower doses of ionizing radiation, 0.25-2.0 Gy, are capable of inducing expression of NF-kB in EBV-transformed 244B human lymphoblastoid cells. These results are in a dose range where the viability of the cells remains very high. After exposure to {sup 137}Cs {gamma} rays at a dose rate of 1.17 Gy/min, a maximum in expression of NF-kB was seen at 8 h after a 0.5-Gy exposure. Time-course studies revealed a biphasic time-dependent expression after 0.5-, 1- and 2-Gy exposures. However, for each time examined, the expression of NF-kB was maximum after the 0.5-Gy exposure. The expression of the p50 and p65 NF-kB subunits was also shown to be regulated differentially after exposures to 1.0 and 2.0 Gy. 32 refs., 3 figs.

Prasad, A.V.; Mohan, N.; Meltz, M.L.; Chandrasekar, B. [Univ. of Texas Health Science Center, San Antonio, TX (United States)

1994-06-01T23:59:59.000Z

244

Low Dose Radiation Research Program: Research Highlights - Ionizing  

NLE Websites -- All DOE Office Websites (Extended Search)

Affects Cancer Frequency and Characteristics by Acting Affects Cancer Frequency and Characteristics by Acting on the Microenvironment Background: For more than a quarter century the scientific rationale for extrapolating radiation health effects has been underpinned by biophysical target theory. Fundamental to target theory is that the effect (e.g., DNA damage, mutation, cancer) is proportional to dose based on interaction of energy with biological targets, specifically DNA. However, the biology following ionizing radiation is more than just DNA damage, repair, or misrepair. Cellular responses to ionizing radiation can affect phenotype, cell interactions, lineage commitment, differentiation and genomic stability, all of which have been widely documented in cultured cells and many observed in vivo. This class of non-targeted effects induced

245

Low Dose Radiation Research Program: Robert L. Ullrich  

NLE Websites -- All DOE Office Websites (Extended Search)

Robert L. Ullrich Robert L. Ullrich Colorado State University Currently Funded Projects Radiation Leukemogenesis at Low Dose Rates (NSCOR) Genetic Mechanisms of Induced Chromosomal Instability and their Relationships with Radiation Tumorigenesis Technical Abstracts 2006 Workshop: The Role of Telomere Dysfunction in Driving Genomic Instability Bailey, S.M., Williams, E.S., and Ullrich, R.L. 2005 Workshop: Dsyfunctional Mammalian Telomeres in DNA-PKcs Deficient Backgrounds Bailey, S.M., Williams, E., Hagelstrom, T., and Ullrich, R.L. 2003 Workshop: Dysfunctional Mammalian Telomeres Join to Double-Strand Breaks Bailey, S.M., Goodwin, E.H., Williams, E., and Ullrich, R.L. 2002 Workshop: Dysfunctional Telomeres, Radiation-Induced Instability and Tumorigenesis Bailey, S.M., Goodwin, E.H., Cornforth, M.N., and Ullrich, R.L.

246

Low Dose Radiation Research Program: Rainer K. Sachs  

NLE Websites -- All DOE Office Websites (Extended Search)

Rainer K. Sachs Rainer K. Sachs University of California, Berkeley Funded Projects BIO-BASED RISK MODELING 03-20: Modeling the Interrelations Among Radiation-Induced Bystander Effects, Genomic Instability and Cancer Cytogenetic Tests of Radiobiological Models Relating Epidemiologically Measurable Risks to Low-Dose Risks Technical Abstracts 2006 Workshop The Bystander Effect in Normal Human 3-D Tissue: Experiments, Models, and Implications Brenner, D., Ponnaiya, B., Shuryak, I., Sachs, R., and Geard, D. Radiation Carcinogenesis Risk as Influenced by Intercellular Interaction Hahnfeldt, P., Hlatky, L., and Sachs, R.K. 2005 Workshop: Modelling Intercellular Interactions During Radiation Carcinogenesis Sachs, R.K., Chan, M., Hlatky, L., and Hahnfeldt, P. 2003 Workshop: Chromosome Spatial Clustering Uncovered Through Radiogenic Aberrations

247

Dose-rate conversion factors for external exposure to photons and electrons  

SciTech Connect

Dose-rate conversion factors for external exposure to photons and electrons have been calculated for approximately 500 radionuclides of potential importance in environmental radiological assessments. The dose-rate factors were obtained using the DOSFACTER computer code. The results given in this report incorporate calculation of electron dose-rate factors for radiosensitive tissues of the skin, improved estimates of organ dose-rate factors for photons, based on organ doses for monoenergetic sources at the body surface of an exposed individual, and the spectra of scattered photons in air from monoenergetic sources in an infinite, uniformly contaminated atmospheric cloud, calculation of dose-rate factors for other radionuclides in addition to those of interest in the nuclear fuel cycle, and incorporation of updated radioactive decay data for all radionuclides. Dose-rate factors are calculated for three exposure modes - immersion in contaminated air, immersion in contaminated water, and exposure at a height of 1 m above a contaminated ground surface. The report presents the equations used to calculate the external dose-rate factors for photons and electrons, documentation of the revised DOSFACTER computer code, and a complete tabulation of the calculated dose-rate factors. 30 refs., 12 figs.

Kocher, D.C.

1981-08-01T23:59:59.000Z

248

Occupational radiation Exposure at Agreement State-Licensed Materials Facilities, 1997-2010  

SciTech Connect

The purpose of this report is to examine occupational radiation exposures received under Agreement State licensees. As such, this report reflects the occupational radiation exposure data contained in the Radiation Exposure Information and Reporting System (REIRS) database, for 1997 through 2010, from Agreement State-licensed materials facilities.

U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research

2012-07-07T23:59:59.000Z

249

Risk of Low Dose/Low Dose Rate Ionizing Radiation to Humans Symposium at the EMS 2009 Annual Meeting - September 2006  

Science Conference Proceedings (OSTI)

The low dose symposium thoughtfully addressed controversy of risk from low dose radiation exposure, hormesis and radon therapy. The stem cell symposium cogently considered the role of DNA damage and repair in hematopoietic stem cells underlying aging and malignancy and provocatively presented evidence that stem cells may have distinct morphologies and replicative properties, as well as special roles in cancer initiation. In the epigenetics symposium, studies illustrated the long range interaction of epigenetic mechanisms, the roles of CTCF and BORIS in region/specific regulation of epigenetic processes, the impact of DNA damage on epigenetic processes as well as links between epigenetic mechanisms and early nutrition and bystander effects.

Morgan, William F.; von Borstel, Robert C.; Brenner,; Redpath, J. Leslie; Erickson, Barbra E.; Brooks,

2009-11-12T23:59:59.000Z

250

Occupational radiation exposure at commercial nuclear power reactors and other facilities 1992; Twenty-fifth annual report, Volume 14  

SciTech Connect

This report summarizes the occupational radiation exposure information that has been reported to the NRC`s Radiation Exposure Information Reporting System (REIRS) by nuclear power facilities and certain other categories of NRC licensees during the years 1969 through 1992. The bulk of the data presented in the report was obtained from annual radiation exposure reports submitted in accordance with the requirements of 10CFR20.407 and the technical specifications of nuclear power plants. Data on workers terminating their employment at certain NRC licensed facilities were obtained from reports submitted pursuant to 10CFR20.408. The 1992 annual reports submitted by about 364 licensees indicated that approximately 204,365 individuals were monitored, 183,927 of whom were monitored by nuclear power facilities. They incurred an average individual dose of 0.16 rem (cSv) and an average measurable dose of about 0.30 (cSv). Termination radiation exposure reports were analyzed to reveal that about 74,566 individuals completed their employment with one or more of the 364 covered licensees during 1992. Some 71,846 of these individuals terminated from power reactor facilities, and about 9,724 of them were considered to be transient workers who received an average dose of 0.50 rem (cSv).

Raddatz, C.T. [US Nuclear Regulatory Commission, Washington, DC (United States). Division of Regulatory Applications; Hagemeyer, D. [Science Applications International Corp., Oak Ridge, TN (United States)

1993-12-01T23:59:59.000Z

251

Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation  

Science Conference Proceedings (OSTI)

We investigated the low dose dependency of the transcriptional response of human cells to characterize the shape and biological functions associated with the dose response curve and to identify common and conserved functions of low dose expressed genes across cells and tissues. Human lymphoblastoid (HL) cells from two unrelated individuals were exposed to graded doses of radiation spanning the range of 1-10 cGy were analyzed by transcriptome profiling, qPCR and bioinformatics, in comparison to sham irradiated samples. A set of {approx}80 genes showed consistent responses in both cell lines; these genes were associated with homeostasis mechanisms (e.g., membrane signaling, molecule transport), subcellular locations (e.g., Golgi, and endoplasmic reticulum), and involved diverse signal transduction pathways. The majority of radiation-modulated genes had plateau-like responses across 1-10 cGy, some with suggestive evidence that transcription was modulated at doses below 1 cGy. MYC, FOS and TP53 were the major network nodes of the low-dose response in HL cells. Comparison our low dose expression findings in HL cells with those of prior studies in mouse brain after whole body exposure, in human keratinocyte cultures, and in endothelial cells cultures, indicates that certain components of the low dose radiation response are broadly conserved across cell types and tissues, independent of proliferation status.

Wyrobek, A. J.; Manohar, C. F.; Nelson, D. O.; Furtado, M. R.; Bhattacharya, M. S.; Marchetti, F.; Coleman, M.A.

2011-04-18T23:59:59.000Z

252

Global methylation responses to low dose radiation exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

comprises a very large proportion of the mouse and human genomes. Using bisulphite modification and quantitative real-time PCR, the method can be used to analyse a very large pool...

253

The proceedings of a symposium on dose rate in mammalian radiation biology, April 29 - May 1, 1968  

SciTech Connect

MAMMALIA. Radiation effects on, effects of dose rate on; RADIOBIOLOGY. Conference on effects of dose rate on radiosensitivity of mammals.

Brown, D.G.; Cragle, R.G.; Noonan, T.R. (eds.)

1968-01-01T23:59:59.000Z

254

Low Dose Radiation Research Program: Quantification of Repair of  

NLE Websites -- All DOE Office Websites (Extended Search)

Quantification of Repair of Low-Dose-Induced DNA Double-Strand Quantification of Repair of Low-Dose-Induced DNA Double-Strand Breaks in Diploid Human Cells Authors: David Schild,1 and Larry H. Thompson,2 Institutions: 1Life Sciences Division, Lawrence Berkeley National Laboratory; and 2BBR Program, Lawrence Livermore National Laboratory Double-strand breaks (DSBs) are the biochemical lesions of primary concern in radiation related health effects. Compelling evidence from rodent and chicken model systems indicates that homologous recombinational repair (HRR) plays an essential role for cell viability in the repair of spontaneous DSBs arising during DNA replication and an important role in the repair of IR-induced DSBs. IR-induced DSBs are also repaired by error-prone nonhomologous end joining (NHEJ). Using hTERT-immortalized

255

Low Dose Radiation Research Program: Optimizing the Scientific, Regulatory  

NLE Websites -- All DOE Office Websites (Extended Search)

Optimizing the Scientific, Regulatory and Societal Impact of the DOE Optimizing the Scientific, Regulatory and Societal Impact of the DOE Low Dose Research Program Authors: Antone L. Brooks Institution: Washington State University Tri-Cities Richland, Washington The purpose of this project is to provide a focal point for communication of the research results from the DOE Low Dose Radiation Research Program. The major communication tool provided by this project is a Website at Washington State University. The website is being maintained to provide communication between the scientific advances generated by the research program and scientists both in and outside the program, policy makers, regulators and the public. The website also contains a number of presentations and illustrations that are written so that they will be easy

256

Radiation-Induced Rib Fractures After Hypofractionated Stereotactic Body Radiation Therapy: Risk Factors and Dose-Volume Relationship  

SciTech Connect

Purpose: The purpose of this study was to clarify the incidence, the clinical risk factors, and the dose-volume relationship of radiation-induced rib fracture (RIRF) after hypofractionated stereotactic body radiation therapy (SBRT). Methods and Materials: One hundred sixteen patients treated with SBRT for primary or metastatic lung cancer at our institution, with at least 6 months of follow-up and no previous overlapping radiation exposure, were included in this study. To determine the clinical risk factors associated with RIRF, correlations between the incidence of RIRF and the variables, including age, sex, diagnosis, gross tumor volume diameter, rib-tumor distance, and use of steroid administration, were analyzed. Dose-volume histogram analysis was also conducted. Regarding the maximum dose, V10, V20, V30, and V40 of the rib, and the incidences of RIRF were compared between the two groups divided by the cutoff value determined by the receiver operating characteristic curves. Results: One hundred sixteen patients and 374 ribs met the inclusion criteria. Among the 116 patients, 28 patients (46 ribs) experienced RIRF. The estimated incidence of rib fracture was 37.7% at 3 years. Limited distance from the rib to the tumor (<2.0 cm) was the only significant risk factor for RIRF (p = 0.0001). Among the dosimetric parameters used for receiver operating characteristic analysis, the maximum dose showed the highest area under the curve. The 3-year estimated risk of RIRF and the determined cutoff value were 45.8% vs. 1.4% (maximum dose, {>=}42.4 Gy or less), 51.6% vs. 2.0% (V40, {>=}0.29 cm{sup 3} or less), 45.8% vs. 2.2% (V30, {>=}1.35 cm{sup 3} or less), 42.0% vs. 8.5% (V20, {>=}3.62 cm{sup 3} or less), or 25.9% vs. 10.5% (V10, {>=}5.03 cm{sup 3} or less). Conclusions: The incidence of RIRF after hypofractionated SBRT is relatively high. The maximum dose and high-dose volume are strongly correlated with RIRF.

Asai, Kaori [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Shioyama, Yoshiyuki, E-mail: shioyama@radiol.med.kyushu-u.ac.jp [Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Nakamura, Katsumasa; Sasaki, Tomonari; Ohga, Saiji; Nonoshita, Takeshi [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Yoshitake, Tadamasa [Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Ohnishi, Kayoko [Department of Radiology, National Center for Global Health and Medicine, Tokyo (Japan)] [Department of Radiology, National Center for Global Health and Medicine, Tokyo (Japan); Terashima, Kotaro; Matsumoto, Keiji [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Hirata, Hideki [Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Honda, Hiroshi [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)

2012-11-01T23:59:59.000Z

257

Low Dose Radiation Research Program: Characterizing Bystander Effects  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation. Irradiation. Authors: L.A. Braby and J.R. Ford. Institutions: Texas A&M University. Bystander effects, which are typically seen as in increase in the cellular concentration of specific repair related molecules or as cytogenetic changes which appear to be the consequence of DNA damage, may be a significant factor in the risk of long-term health effects of low doses of radiation. These effects clearly increase the effective size of the target for radiation response, from the diameter of a single cell or cell nucleus to something significantly larger, by bringing additional cells into the process. It is unclear whether this larger target will result in an increase or a decrease in the probability of inducing a change which would be detrimental to the health of the organism, but it clearly reduces the

258

Low Dose Radiation Research Program: Genetic Mechanisms of Induced  

NLE Websites -- All DOE Office Websites (Extended Search)

Mechanisms of Induced Chromosomal Instability and their Mechanisms of Induced Chromosomal Instability and their Relationships with Radiation Tumorigenesis Robert Ullrich Colorado State University Why This Project A combination of epidemiological, experimental, animal, and cellular molecular data is used in the estimation of tumor risk after low doses of low-LET radiation. Uncertainties are recognized in the interpretation of all these data sets, and recent findings concerning genomic instability in irradiated cells challenge the conventional view that induced DNA damage is expressed during the immediate post-irradiation cell cycle. These data on genomic instability are based largely upon studies of cell cultures the mechanisms involved and implications for tumor formation in living organisms remain unclear. Nevertheless, if induced genomic instability were

259

Low Dose Radiation Research Program: Cooperation Between Homologous  

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Cooperation Between Homologous Recombination and the Fanconi Anemia Cooperation Between Homologous Recombination and the Fanconi Anemia Cancer Suppressor Proteins in Minimizing Spontaneous and Radiation-Induced Chromosomal Instability Authors: Larry H. Thompson, John M. Hinz, Robert S. Tebbs, and N. Alice Yamada Institutions: Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, California Purpose and experimental approach. This study addresses the genetic basis of spontaneous mutagenesis as a means of understanding the DNA damage-response pathways that maintain chromosome stability. It is our view that knowledge of these processes is fundamental to understanding how low dose ionizing radiation (IR) produces chromosomal rearrangements that lead to carcinogenesis. Endogenous oxidative DNA damage is presumed to be a

260

Hysterosalpingography using a flat panel unit: Evaluation and optimization of ovarian radiation dose  

Science Conference Proceedings (OSTI)

Purpose: The aim of the present study was the evaluation and optimization of radiation dose to the ovaries (D) in hysterosalpingography (HSG). Methods: The study included a phantom study and a clinical one. In the phantom study, we evaluated imaging results for different geometrical setups and irradiation conditions. In the clinical study, 34 women were assigned into three different fluoroscopy modes and D was estimated with direct cervical TLD measurements. Results: In the phantom study, we used a source-to-image-distance (SID) of 110 cm and a field diagonal of 48 cm, and thus decreased air KERMA rate (KR) by 19% and 70%, respectively, for beam filtration: 4 mm Al and 0.9 mm Cu (Low dose). The least radiation exposure was accomplished by using the 3.75 pps fluoroscopy mode in conjunction with beam filtration: Low dose. In the clinical study, D normalized to 50 s of fluoroscopy time with a 3.75 pps fluoroscopy mode reached a value of 0.45 {+-} 0.04 mGy. Observers' evaluation of diagnostic image quality did not significantly differ for the three different modes of acquisition that were compared. Conclusions: Digital spot radiographs could be omitted in modern flat panel systems during HSG. Fluoroscopy image acquisitions in a modern flat panel unit at 3.75 pps and a beam filtration of 4 mm Al and 0.9 mm Cu demonstrate acceptable image quality with an average D equal to 0.45 mGy. This value is lower compared to the studied literature. For these reasons, the proposed method may be recommended for routine HSG examination in order to limit radiation exposure to the ovaries.

Messaris, Gerasimos A. T.; Abatzis, Ilias; Kagadis, George C.; Samartzis, Alexandros P.; Athanasopoulou, Panagiota; Christeas, Nikolaos; Katsanos, Konstantinos; Karnabatidis, Dimitrios; Nikiforidis, George C. [Department of Medical Physics, University Hospital of Patras, GR 265 04 Rion (Greece); Department of Medical Physics, School of Medicine, University of Patras, GR 265 04 Rion (Greece); Department of Medical Physics, University Hospital of Patras, GR 265 04 Rion, Greece and Department of Medical Physics, School of Medicine, University of Patras, GR 265 04 Rion (Greece); Department of Medical Physics, 'EVANGELISMOS' General Hospital, 45-47 Ypsilantou Street, GR 106 76 Athens (Greece); Philips Hellas, 44 Kifisias Avenue, GR 151 25 Marousi (Greece); Department of Radiology, School of Medicine, University of Patras, GR 265 04 Rion (Greece); Department of Medical Physics, University Hospital of Patras, GR 265 04 Rion, Greece and Department of Medical Physics, School of Medicine, University of Patras, GR 265 04 Rion (Greece)

2012-07-15T23:59:59.000Z

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

KUB5/HERA: a dual acting protein that suppresses genomic instability and promotes DNA repair after low dose IR exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

KUB5/HERA: a dual acting protein that suppresses genomic instability and KUB5/HERA: a dual acting protein that suppresses genomic instability and promotes DNA repair after low dose IR exposure Julio C. Morales 1 , Amy Rommel 1 , Konstantin Leskov 2 , Walter M. Hittelman 3 , David A. Boothman 1# 1 Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. 2 Department of Radiation Oncology, Case Western Reserve University, Cleveland, OH 44106, USA. 3 Department of Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX 77030, USA. # To whom correspondence should be addressed. E-mail: David.Boothman@utsouthwestern.edu Eukaryotic cells can respond to DNA double strand breaks created by low doses of IR by activating homologous recombination (HR) or non-homologous end- joining (NHEJ) pathways to repair DNA. A yeast two-hybrid screen using Ku70 as

262

DOE-STD-1153-2002; A Graded Approach for Evaluating Radiation Doses to Aquatic and Terrestrial Biota  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

M3-19 M3-19 3 Equations and Models for Calculating Dose to Biota and Deriving BCGs Based on the potential pathways of exposure, BCGs were derived for surface water, sediment, and soil. Calculated using conservative assumptions, the BCGs are intended to preclude the relevant biota from being exposed to radiation levels in excess of established or recommended biota dose limits. Determination of compliance with the dose limits requires that all organism- relevant environmental media be evaluated at the same time. This is done by using the "sum of fractions" approach commonly used in evaluating radionuclide discharges to the environment. 3.1 An Important Note on Estimating Internal Tissue Concentrations for Use in Dose Equations: The Lumped Parameter For most radionuclides, the single most important predictor of biota dose is the method used to estimate internal tissue concentrations.

263

Radiation dose-rate meter using an energy-sensitive counter  

DOE Patents (OSTI)

A radiation dose-rate meter is provided which uses an energy-sensitive detector and combines charge quantization and pulse-rate measurement to monitor radiation dose rates. The charge from each detected photon is quantized by level-sensitive comparators so that the resulting total output pulse rate is proportional to the dose-rate. 3 figs.

Kopp, M.K.

1986-12-17T23:59:59.000Z

264

Radiation dose-rate meter using an energy-sensitive counter  

DOE Patents (OSTI)

A radiation dose-rate meter is provided which uses an energy-sensitive detector and combines charge quantization and pulse-rate measurement to monitor radiation dose rates. The charge from each detected photon is quantized by level-sensitive comparators so that the resulting total output pulse rate is proportional to the dose-rate.

Kopp, Manfred K. (Oak Ridge, TN)

1988-01-01T23:59:59.000Z

265

The risk of leukemia from low doses of low-LET radiation  

Science Conference Proceedings (OSTI)

In this communication, we examine the evidence (if any) for a nonlinear dose response in relation to leukemia mortality in the Japanese A-bomb population. Specifically, we seek an estimate of the probability that, at low doses of radiation, the relative ... Keywords: A-bomb survivors, Hormesis, Leukemia risk, Low doses of radiation

M. Zaider

2001-06-01T23:59:59.000Z

266

Low Dose Radiation Research Program: Use of Computational Modeling to  

NLE Websites -- All DOE Office Websites (Extended Search)

Use of Computational Modeling to Evaluate Hypotheses about the Use of Computational Modeling to Evaluate Hypotheses about the Molecular and Cellular Mechanisms of Bystander Effects Authors: Yuchao “Maggie” Zhao and Rory Conolly Institutions: CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, North Carolina A detailed understanding of the biological mechanisms of radiation-induced damage at the molecular and cellular levels is needed for accurate assessment of the shape of the dose-response curve for radiationinduced health effects in the intact organism. Computational models can contribute to the improved understanding of mechanisms through integration of data and quantitative evaluation of hypotheses. We propose to develop a novel computational model of bystander effects elicited by oxidative stress and a

267

Workshop Report on Atomic Bomb Dosimetry--Residual Radiation Exposure: Recent Research and Suggestions for Future Studies  

SciTech Connect

There is a need for accurate dosimetry for studies of health effects in the Japanese atomic bomb survivors because of the important role that these studies play in worldwide radiation protection standards. International experts have developed dosimetry systems, such as the Dosimetry System 2002 (DS02), which assess the initial radiation exposure to gamma rays and neutrons but only briefly consider the possibility of some minimal contribution to the total body dose by residual radiation exposure. In recognition of the need for an up-to-date review of the topic of residual radiation exposure in Hiroshima and Nagasaki, recently reported studies were reviewed at a technical session at the 57th Annual Meeting of the Health Physics Society in Sacramento, California, 22-26 July 2012. A one-day workshop was also held to provide time for detailed discussion of these newer studies and to evaluate their potential use in clarifying the residual radiation exposures to the atomic-bomb survivors at Hiroshima and Nagasaki. Suggestions for possible future studies are also included in this workshop report.

none,

2013-06-06T23:59:59.000Z

268

Investigation of non-targeted effects of low dose ionizing radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

Investigation of non-targeted effects of low dose ionizing radiation on the mammary gland utilizing three-dimensional culture models of mammary cells derived from mouse strains...

269

Effect of Low Dose Radiation on Antioxidant Levels in Rat Brain  

NLE Websites -- All DOE Office Websites (Extended Search)

Low Dose Radiation on Antioxidant Levels in Rat Brain Mohan Doss Fox Chase Cancer Center Abstract Background: Parkinsons disease (PD) is characterized by progressive...

270

Using Co-Regulation to Understand Low-Dose Ionizing Radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

with low and high doses of ionizing radiation (IR). Pathway analysis suggested that chromatin structure, as well as transcription control, plays a large role in linking gene...

271

Profiling of MnSOD Interaction Proteins in Low-Dose Radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

Proteins in Low-Dose Radiation Induced Adaptive Response Angela Eldridge 1 , Ming Fan 1 , Demet Candas 1 , Brett Chromy, and Jian Jian Li 1 1 Department of Radiation...

272

Analysis of radiation exposure for additional naval personnel at Operation CASTLE - supplemental report. Technical report, 24 Apr-20 Nov 89  

SciTech Connect

This report supplements DNA-TR-84-6 by analyzing the radiation exposure for typical crewmembers of eight additional ships at Operation CASTLE in 1954: RECLAIMER, SHEA, COCOPA, MENDER, MOLALA, TAWAKONI, PC-1546, and LST-1146. Utilizing the reconstructed radiation environments from deck contamination, water shine, proximate ship shine, and contaminated hulls and piping, equivalent film badge doses are calculated and compared with analyzed film badge dosimetry. Comparisons are hampered by a shortage of badge readings and by cohort badging that may have emphasized non-representative crew activities. Considering this, agreement is good (within a few hundred millirem) when doses were high but less when doses were low. In all cases, overall totals appear to be in excellent agreement.

Thomas, C.; Geotz, J.; Klemm, J.; Ortlieb, E.

1991-10-01T23:59:59.000Z

273

Low Dose Radiation Research Program: David J. Chen  

NLE Websites -- All DOE Office Websites (Extended Search)

2003 Workshop: Gene Expression Profile of Normal Human Fibroblast After Ionizing Irradiation, a comparison study between low dose and high dose. Chen, D.J. 2002 Workshop:...

274

Low Dose Radiation Research Program Website ? Highlighting Low...  

NLE Websites -- All DOE Office Websites (Extended Search)

Research Program Website - Highlighting Low Dose Research Bill Morgan, Principal Investigator; Julie Wiley, Website Content Manager; Christine Novak, Webmaster The Low Dose...

275

Review of US and Japanese Methods to Reduce Personnel Dose and Control Radiation Fields  

Science Conference Proceedings (OSTI)

This report summarizes aspects of U.S. nuclear industry's performance in several areas related to radiation exposure management. The document supports efforts of the Japan Nuclear Energy Safety Organization (JNES) to find ways to reduce radiation exposure in Japanese plants.

2008-09-30T23:59:59.000Z

276

Occupational radiation exposure at commercial nuclear power reactors and other facilities 1996: Twenty-ninth annual report. Volume 18  

SciTech Connect

This report summarizes the occupational exposure data that are maintained in the US Nuclear Regulatory Commission`s (NRC) Radiation Exposure Information and Reporting System (REIRS). The bulk of the information contained in the report was compiled from the 1996 annual reports submitted by six of the seven categories of NRC licensees subject to the reporting requirements of 10 CFR 20.2206. Since there are no geologic repositories for high level waste currently licensed, only six categories will be considered in this report. Annual reports for 1996 were received from a total of 300 NRC licensees, of which 109 were operators of nuclear power reactors in commercial operation. Compilations of the reports submitted by the 300 licensees indicated that 138,310 individuals were monitored, 75,139 of whom received a measurable dose. The collective dose incurred by these individuals was 21,755 person-cSv (person-rem){sup 2} which represents a 13% decrease from the 1995 value. The number of workers receiving a measurable dose also decreased, resulting in the average measurable dose of 0.29 cSv (rem) for 1996. The average measurable dose is defined to be the total collective dose (TEDE) divided by the number of workers receiving a measurable dose. These figures have been adjusted to account for transient reactor workers. Analyses of transient worker data indicate that 22,348 individuals completed work assignments at two or more licensees during the monitoring year. The dose distributions are adjusted each year to account for the duplicate reporting of transient workers by multiple licensees. In 1996, the average measurable dose calculated from reported was 0.24 cSv (rem). The corrected dose distribution resulted in an average measurable dose of 0.29 cSv (rem).

Thomas, M.L. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Regulatory Applications; Hagemeyer, D. [Science Applications International Corp., Oak Ridge, TN (United States)

1998-02-01T23:59:59.000Z

277

An optimized colony forming assay for low-dose-radiation cell survival measurement  

Science Conference Proceedings (OSTI)

The aim of this study is to develop a simple and reliable method to quantify the cell survival of low-dose irradiations. Two crucial factors were considered, the same number of cells plated in each flask and an appropriate interval between cell plating and irradiation. For the former, we optimized cell harvest with trypsin, diluted cells in one container, and directly seeded cells on the bottom of flasks in a low density before irradiation. Reproducible plating efficiency was obtained. For the latter, we plated cells on the bottom of flasks and then monitored the processing of attachment, cell cycle variations, and the plating efficiency after exposure to 20 cGy of X-rays. The results showed that a period of 4.5 h to 7.5 h after plating was suitable for further treatment. In order to confirm the reliability and feasibility of our method, we also measured the survival curves of these M059K and M059J glioma cell lines by following the optimized protocol and obtained consistent results reported by others with cell sorting system. In conclusion, we successfully developed a reliable and simple way to measure the survival fractions of human cells exposed to low dose irradiation, which might be helpful for the studies on low-dose radiation biology.

Zhu J.; Sutherland B.; Hu W.; Ding N.; Ye C.; Usikalu M.; Li S.; Hu B.; Zhou G.

2011-11-01T23:59:59.000Z

278

Induction of nuclear factor kB after low-dose ionizing radiation involves a reactive oxygen intermediate signaling pathway  

Science Conference Proceedings (OSTI)

Reactive oxygen intermediates (ROIs) have been found to be the messengers in the activation of the kB transcription regulator in mitogen- or cytokine-stimulated cells, operating in conjunction with or independently of various other mechanisms; these include Ca{sup ++}-dependent and PKC-dependent cytoplasmic signaling pathways. We have recently reported that low-dose ionizing radiation induces NF-kB in human lymphoblastoid 244B cells. Since ionizing radiation generates free radicals in cells, we have investigated whether the ROIs generated by ionizing radiation induce NF-kB activity, and also whether they do so by a similar mechanism as in cells treated with PMA or H{sub 2}O{sub 2}. The results not only confirm a previous observation from our laboratory that low-dose ionizing radiation (0.1-2.0 Gy) activates kB transcription factor transiently with a maximal induction at 0.5 Gy exposure, but also demonstrate mechanistically that the activation of NF-kB by low-dose ionizing radiation can be inhibited considerably by the antioxidant N-acetyl-L-cysteine, indicating that at least the major part of the activation process is mediated by ROIs. These findings support the idea that ROIs can regulate the kB elements which in turn can serve as response elements for oxidant stress. 37 refs., 4 figs., 1 tab.

Mohan, N.; Meltz, M.L. [Univ. of Texas Health Science Center, San Antonio, TX (United States)

1994-10-01T23:59:59.000Z

279

Statistical issues in radiation dose-response analysis of employees of the nuclear industry in Oak Ridge, Tennessee  

Science Conference Proceedings (OSTI)

Poisson regression methods are used to describe dose-response relations for cancer mortality for a subcohort of 28,347 white male radiation workers. Age specific baseline rates are described using both internal and external (US white male) rates. Regression analyses are based on an analytic data structure (ADS) that consists of a table of observed deaths, expected deaths, and person-years at risk for each combination of levels of seven risk factors. The factors are socioeconomic status, length of employment, birth cohort, age at risk, facility, internal exposure, and external exposure. Each observation in the ADS consists of the index value of each of the stratifying factors, the observed deaths, the expected deaths, the person-years, and the ten year lagged average cumulative dose. Regression diagnostics show that a linear exponential relative risk model is not appropriate for these data. Results are presented using a main effects model for factors other than external radiation, and an excess relative risk term for cumulative external radiation dose.

Frome, E.L. [Oak Ridge National Lab., TN (United States); Watkins, J.P. [Oak Ridge Inst. for Science and Education, TN (United States). Center for Epidemiologic Research

1997-11-01T23:59:59.000Z

280

Low Dose Radiation Research Program: Induction of Genomic Instability...  

NLE Websites -- All DOE Office Websites (Extended Search)

Brook Why This Project Genomic instability is an important step in radiation-induced cancer. We will investigate one potential repair mechanism involved in radiation-induced...

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

External Dose Estimates from  

E-Print Network (OSTI)

Appendix G External Dose Estimates from Global Fallout G-1 #12;External Radiation Exposure from the fallout from all of these tests was about 0.7 mSv, about equivalent to 2-3 years of external radiation exposure from natural background. In contrast to the fallout from tests at the Nevada Test site

282

Complexity analysis of the UV radiation dose time series  

E-Print Network (OSTI)

We have used the Lempel-Ziv and sample entropy measures to assess the complexity in the UV radiation activity in the Vojvodina region (Serbia) for the period 1990-2007. In particular, we have examined the reconstructed daily sum (dose) of the UV-B time series from seven representative places in this region and calculated the Lempel-Ziv Complexity (LZC) and Sample Entropy (SE) values for each time series. The results indicate that the LZC values in some places are close to each other while in others they differ. We have devided the period 1990-2007 into two subintervals: (a) 1990-1998 and (b) 1999-2007 and calculated LZC and SE values for the various time series in these subintervals. It is found that during the period 1999-2007, there is a decrease in their complexities, and corresponding changes in the SE, in comparison to the period 1990-1998. This complexity loss may be attributed to increased (i) human intervention in the post civil war period (land and crop use and urbanization) and military activities i...

Mihailovic, Dragutin T

2013-01-01T23:59:59.000Z

283

Program on Technology Innovation: Evaluation of Updated Research on the Health Effects and Risks Associated with Low-Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

The Electric Power Research Institute (EPRI) has performed a systematic review of recently published, peer-reviewed scientific studies in the fields of epidemiology and radiobiology that discuss health risks associated with exposure to low levels of ionizing radiation. As a result of this study, the EPRI team concludes that there is a need to re-evaluate the magnitude of dose and dose-rate effectiveness factors (DDREF), including the significant body of radiobiology data that suggests non-linear risks at...

2009-11-18T23:59:59.000Z

284

Low Dose Radiation Research Program: Comparison of DNA Damage Risk from  

NLE Websites -- All DOE Office Websites (Extended Search)

Comparison of DNA Damage Risk from Low-Dose Radiation and Folate Comparison of DNA Damage Risk from Low-Dose Radiation and Folate Deficiency. Authors: Chantal Courtemanche, Arnold C. Huang, Nicole Kerry, Bernice Ng, and Bruce N. Ames. Institutions: Children’s Hospital Oakland Research Institute, Oakland, California. Our overall goal is to understand and quantify the real effects of low-dose radiation by measuring direct and specific cellular changes. However, since the background dose of radiation to which most individuals are exposed is well below the levels where significant biological effects, such as mutation or tumor induction, are observed, our novel approach is to compare the consequences of radiation to those of specific nutritional deficiencies. By determining which of these two common stresses at physiologically relevant doses leads to a greater amount of DNA damage, we

285

Out-of-Field Cell Survival Following Exposure to Intensity-Modulated Radiation Fields  

Science Conference Proceedings (OSTI)

Purpose: To determine the in-field and out-of-field cell survival of cells irradiated with either primary field or scattered radiation in the presence and absence of intercellular communication. Methods and Materials: Cell survival was determined by clonogenic assay in human prostate cancer (DU145) and primary fibroblast (AGO1552) cells following exposure to different field configurations delivered using a 6-MV photon beam produced with a Varian linear accelerator. Results: Nonuniform dose distributions were delivered using a multileaf collimator (MLC) in which half of the cell population was shielded. Clonogenic survival in the shielded region was significantly lower than that predicted from the linear quadratic model. In both cell lines, the out-of-field responses appeared to saturate at 40%-50% survival at a scattered dose of 0.70 Gy in DU-145 cells and 0.24 Gy in AGO1522 cells. There was an approximately eightfold difference in the initial slopes of the out-of-field response compared with the {alpha}-component of the uniform field response. In contrast, cells in the exposed part of the field showed increased survival. These observations were abrogated by direct physical inhibition of cellular communication and by the addition of the inducible nitric oxide synthase inhibitor aminoguanidine known to inhibit intercellular bystander effects. Additional studies showed the proportion of cells irradiated and dose delivered to the shielded and exposed regions of the field to impact on response. Conclusions: These data demonstrate out-of-field effects as important determinants of cell survival following exposure to modulated irradiation fields with cellular communication between differentially irradiated cell populations playing an important role. Validation of these observations in additional cell models may facilitate the refinement of existing radiobiological models and the observations considered important determinants of cell survival.

Butterworth, Karl T., E-mail: k.butterworth@qub.ac.u [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); McGarry, Conor K. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Radiotherapy Physics, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Northern Ireland (United Kingdom); Trainor, Colman [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); O'Sullivan, Joe M. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Clinical Oncology, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Belfast, Northern Ireland (United Kingdom); Hounsell, Alan R. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Radiotherapy Physics, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Northern Ireland (United Kingdom); Prise, Kevin M. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom)

2011-04-01T23:59:59.000Z

286

Radiation Exposure Information Reporting System (REIRS) Update, 2012  

SciTech Connect

A series of graphs gives data through the year 2012 for annual collective doses, collective dose per reactor, number of individuals with measurable doses both in total and per reactor, number of reactors, electricity generated, measurable doses per individual and per megawatt-year, and collective outage hours. Reactors considered include BWR, PWR, and LWR. Also, the total effective dose equivalent for the period 2010-2012 is tabulated for each nuclear power plant considered, and the change over 2009-2011.

none,

2013-01-01T23:59:59.000Z

287

Low-dose, low-LET γ-radiation alters carcinogen-induced splenic cytokine production and immune cell phenotype of A/J mice  

NLE Websites -- All DOE Office Websites (Extended Search)

dose, low-LET γ-radiation alters carcinogen-induced splenic cytokine production and immune cell dose, low-LET γ-radiation alters carcinogen-induced splenic cytokine production and immune cell phenotype of A/J mice. V. Gonzales, K. Gott, M. Makvandi, N. Kikendall, A. Monier, E. Maloy, C. Rietz, B. Scott and J. Wilder. Lovelace Respiratory Research Institute, Albuquerque, NM. Introduction: Low-dose, low-linear-energy-transfer (LET) radiation (LDR; < 100 mGy) activates the immune response, presumably via epigenetic pathways (Scott et al. 2009) and may lead to cancer suppression (Nowosielska et al. 2006). One of the mechanisms by which it might do so is by altering the cytokines produced after carcinogen and/or radiation exposure. Alternatively, LDR may activate

288

Non-Targeted Effects of Low Dose Ionizing Radiation Act Via TGFβ...  

NLE Websites -- All DOE Office Websites (Extended Search)

effect that mediates microenvironment composition. TGF is activated in mouse mammary gland following whole body exposure to doses of as low as 0.1 Gy and persists in the stroma...

289

Recommendations to the Technical Steering Panel regarding approach for estimating individual radiation doses resulting from releases of radionuclides to the Columbia River  

Science Conference Proceedings (OSTI)

At the direction of the Technical Steering Panel (TSP) of the Hanford Environmental Dose Reconstruction (HEDR) Project, Battelle staff have reviewed and analyzed available data regarding possible historical radiation doses to individuals resulting from radionuclide releases to the Columbia River. The objective of this review was to recommend to the TSP the spatial and temporal scope and level of effort on Columbia River work to most effectively extend work performed in Phase I of the project (PNL 1991a, PNL 1991b) to meet the project objectives. A number of options were analyzed. Four stretches of the Columbia River and adjacent Pacific coastal waters were defined and investigated for four time periods. Radiation doses arising from ten potentially major exposure pathways were evaluated for each of the time/location combinations, and several alternative methods were defined for estimating the doses from each pathway. Preliminary cost estimates were also developed for implementing dose estimation activities for each of the possible combinations.

Napier, B.A.; Brothers, A.J.

1992-07-01T23:59:59.000Z

290

Recommendations to the Technical Steering Panel regarding approach for estimating individual radiation doses resulting from releases of radionuclides to the Columbia River. Volume 1, Recommendations  

Science Conference Proceedings (OSTI)

At the direction of the Technical Steering Panel (TSP) of the Hanford Environmental Dose Reconstruction (HEDR) Project, Battelle staff have reviewed and analyzed available data regarding possible historical radiation doses to individuals resulting from radionuclide releases to the Columbia River. The objective of this review was to recommend to the TSP the spatial and temporal scope and level of effort on Columbia River work to most effectively extend work performed in Phase I of the project (PNL 1991a, PNL 1991b) to meet the project objectives. A number of options were analyzed. Four stretches of the Columbia River and adjacent Pacific coastal waters were defined and investigated for four time periods. Radiation doses arising from ten potentially major exposure pathways were evaluated for each of the time/location combinations, and several alternative methods were defined for estimating the doses from each pathway. Preliminary cost estimates were also developed for implementing dose estimation activities for each of the possible combinations.

Napier, B.A.; Brothers, A.J.

1992-07-01T23:59:59.000Z

291

Dose distribution for /sup 125/I implants due to anisotropic radiation emission and unknown seed orientation  

SciTech Connect

Variations in dose distribution due to anisotropic radiation emission around /sup 125/I seeds and a lack of knowledge about the orientation of the implanted seeds have been investigated. Upper and lower bounds for dose distributions have been calculated for planar implants using the experimentally determined angular dose distribution around a typical /sup 125/I seed. Results of our study suggest that significant dose variations in the center and the periphery of the implanted area are possible.

Prasad, S.C.; Bassano, D.A.; Fear, P.I.

1987-03-01T23:59:59.000Z

292

New mammography screen/film combinations: Imaging characteristics and radiation dose  

Science Conference Proceedings (OSTI)

Five types of film (Kodak OM, Kodak OM-SO177, Konica CM, Dupont Microvision, and Fuji MiMa) exposed in combination with seven different intensifying screens (Min R, Min R Medium, Siemens Orthox MA, Kyokka HR Mammo Fine, Agfa Gevaert Detail S (old and new), and Konica Monarch) were processed for either 90 sec (at 33.3{degrees}C) or 3 min (at 35.0 degrees C). The films imaged a Computerized Imaging Reference System phantom with additional detail test objects placed on its surface to produce four groups of objects with which to evaluate resolution and contrast. For objects that tested resolution, the Kyokka HR Mammo Fine (Fuji) screen was statistically significantly superior; for objects that tested contrast, the Konica Monarch screen was statistically significantly superior. Extended processing did not affect Dupont and Kodak OM film as much as it affected the other films. It did affect contrast for the other films tested. The mean glandular doses from gridless exposures ranged from 32 to 80 mrad (0.32-0.80 mGy) over all film/screen/processing combinations for a 4.5-cm-thick test object. Several new film/screen combinations can provide images superior to the Kodak Min R/OM combination at a reduced radiation dose. The Kyokka HR Mammo Fine (Fuji) screen was found statistically superior in radiographic resolution of mammographic test objects and the Konica Monarch screen was found to be superior in defining contrast.

Kimme-Smith, C.; Bassett, L.W.; Gold, R.H.; Zheutlin, J.; Gornbein, J.A. (Iris Cantor Center for Breast Imaging, CA (USA))

1990-04-01T23:59:59.000Z

293

Low Dose Radiation Research Program: Frequently Asked Questions  

NLE Websites -- All DOE Office Websites (Extended Search)

between these exposures and an increased cancer risk. National Academy of Sciences Report, Possible health effects of residential electric and magnetic fields. Return to top...

294

Low Dose Radiation Research Program: Communicating the Science of the Low  

NLE Websites -- All DOE Office Websites (Extended Search)

Communicating the Science of the Low Dose Radiation Research Program Communicating the Science of the Low Dose Radiation Research Program Authors: John S. Wassom, Elizabeth T. Owens, Sheryl A. Martin, Amy K. Wolfe, Margaret K. Lyday,* and Susan L. Dimmick** Institutions: Oak Ridge National Laboratory, *Keener Communications, and the **University of Tennessee Graduate School of Medicine. Summary The project team developed a communications plan based on an explicit communications strategy. The plan presents a set of strategic goals, identifies categories of stakeholders relevant to the program, and suggests methods that can be used to achieve strategic goals and reach targeted stakeholders. Context is key to the communication plan. Providing contextual information about low dose radiation, radiation biology, and Low Dose Radiation

295

Annual report shows potential INL radiation dose well below safe regulatory  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Annual report shows potential INL radiation dose well below safe Annual report shows potential INL radiation dose well below safe regulatory limits Annual report shows potential INL radiation dose well below safe regulatory limits August 9, 2011 - 12:00pm Addthis Media Contact Tim Jackson, DOE-Idaho Operations Office 208-526-8484 The U.S. Department of Energy's Idaho Operations Office reported this month that radiation from the site falls well below limits established by the U.S. Environmental Protection Agency. The annual report's conclusions are supported by direct environmental monitoring data routinely taken during the year, and show that activities at the Idaho National Laboratory (INL) site are protective of human health and the environment. Data shows that the INL site potential radiation dose is less than 1% of

296

Estimation of radiation-induced cancer from three-dimensional dose distributions: Concept of organ equivalent dose  

SciTech Connect

Purpose: Estimates of secondary cancer risk after radiotherapy are becoming more important for comparative treatment planning. Modern treatment planning systems provide accurate three-dimensional dose distributions for each individual patient. These data open up new possibilities for more precise estimates of secondary cancer incidence rates in the irradiated organs. We report a new method to estimate organ-specific radiation-induced cancer incidence rates. The concept of an organ equivalent dose (OED) for radiation-induced cancer assumes that any two dose distributions in an organ are equivalent if they cause the same radiation-induced cancer incidence. Methods and Materials: The two operational parameters of the OED concept are the organ-specific cancer incidence rate at low doses, which is taken from the data of the atomic bomb survivors, and cell sterilization at higher doses. The effect of cell sterilization in various organs was estimated by analyzing the secondary cancer incidence data of patients with Hodgkin's disease who were treated with radiotherapy in between 1962 and 1993. The radiotherapy plans used at the time the patients had been treated were reconstructed on a fully segmented whole body CT scan. The dose distributions were calculated in individual organs for which cancer incidence data were available. The model parameter that described cell sterilization was obtained by analyzing the dose and cancer incidence rates for the individual organs. Results: We found organ-specific cell radiosensitivities that varied from 0.017 for the mouth and pharynx up to 1.592 for the bladder. Using the two model parameters (organ-specific cancer incidence rate and the parameter characterizing cell sterilization), the OED concept can be applied to any three-dimensional dose distribution to analyze cancer incidence. Conclusion: We believe that the concept of OED presented in this investigation represents a first step in assessing the potential risk of secondary cancer induction after the clinical application of radiotherapy.

Schneider, Uwe [Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, City Hospital Triemli, Zurich (Switzerland)]. E-mail: uwe.schneider@psi.ch; Zwahlen, Daniel [Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, City Hospital Triemli, Zurich (Switzerland); Ross, Dieter [Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, City Hospital Triemli, Zurich (Switzerland); Kaser-Hotz, Barbara [Division of Diagnostic Imaging and Radio-Oncology, Vetsuisse Faculty, University of Zuerich, Zurich (Switzerland)

2005-04-01T23:59:59.000Z

297

Characterization of the role of Fhit in maintenance of genomic integrity following low dose radiation, in vivo and in vitro  

Science Conference Proceedings (OSTI)

The major goal of this study is to determine the effects of the Fhit pathway on low dose (radiation (IR)-induced genetic instability. Reduction of Fhit protein expression is observed in most solid tumors particularly in those tumors resulting from exposure to environmental carcinogens. Therefore, characterization of the role of the Fhit-dependent pathway in preventing low dose IR-induced genetic instability will provide useful parameters for evaluating the low dose IR-induced risk of mutagenesis and carcinogenesis. We pursued 3 specific aims to study our hypothesis that the Fhit-dependent pathways maintain genomic integrity through adjusting checkpoint response and repair genes expression following low dose IR. Aim 1: Determine whether Fhit interaction with RPA is necessary for Fhit to affect the cellular response to low dose IR. We combined the approaches of in vitro (GST pull-down and site-directed mutagenesis) and in vivo (observing the co-localization and immunoprecipitation of Fhit and RPA in Fhit knock out mouse cells transfected with mutant Fhit which has lost ability to interact with RPA in vitro). Aim 2: Determine the role of genes whose expression is affected by Fhit in low dose irradiated cells. We analyzed the distinct signature of gene expression in low dose irradiated Fhit-/- cells compared with Fhit+/+ cells by combining microarray, gene transfection and siRNA approaches. Aim 3: Determine the role of Fhit in genetic susceptibility to low dose IR in vivo. We compared the gene mutation frequency and the fragile site stability in the cells isolated from the Fhit+/+ and Fhit-/- mice at 1.5 years following low dose IR. These results determine the role of the Fhit-dependent pathway in maintaining genomic integrity in vitro and in vivo, which provide a basis for choosing surrogate markers in the Fhit-dependent pathway to evaluate low dose IR-induced risk of mutagenesis and carcinogenesis.

Wang, Ya

2010-05-14T23:59:59.000Z

298

Characterization of the role of Fhit in maintenance of genomic integrity following low dose radiation, in vivo and in vitro  

Science Conference Proceedings (OSTI)

The major goal of this study is to determine the effects of the Fhit pathway on low dose ({le} 0.1 Gy) ionizing radiation (IR)-induced genetic instability. Reduction of Fhit protein expression is observed in most solid tumors particularly in those tumors resulting from exposure to environmental carcinogens. Therefore, characterization of the role of the Fhit-dependent pathway in preventing low dose IR-induced genetic instability will provide useful parameters for evaluating the low dose IR-induced risk of mutagenesis and carcinogenesis. We pursued 3 specific aims to study our hypothesis that the Fhit-dependent pathways maintain genomic integrity through adjusting checkpoint response and repair genes expression following low dose IR. Aim 1: Determine whether Fhit interaction with RPA is necessary for Fhit to affect the cellular response to low dose IR. We combined the approaches of in vitro (GST pull-down and site-directed mutagenesis) and in vivo (observing the co-localization and immunoprecipitation of Fhit and RPA in Fhit knock out mouse cells transfected with mutant Fhit which has lost ability to interact with RPA in vitro). Aim 2: Determine the role of genes whose expression is affected by Fhit in low dose irradiated cells. We analyzed the distinct signature of gene expression in low dose irradiated Fhit-/- cells compared with Fhit+/+ cells by combining microarray, gene transfection and siRNA approaches. Aim 3: Determine the role of Fhit in genetic susceptibility to low dose IR in vivo. We compared the gene mutation frequency and the fragile site stability in the cells isolated from the Fhit+/+ and Fhit-/- mice at 1.5 years following low dose IR. These results determine the role of the Fhit-dependent pathway in maintaining genomic integrity in vitro and in vivo, which provide a basis for choosing surrogate markers in the Fhit-dependent pathway to evaluate low dose IR-induced risk of mutagenesis and carcinogenesis.

Ya Wang

2010-05-31T23:59:59.000Z

299

Low Dose Radiation Research Program: X-ray Microbeam Bystander...  

NLE Websites -- All DOE Office Websites (Extended Search)

experiments, cultures grown in microwell slide chambers were irradiated with precise stripes of dose up to 100m wide. Samples were processed for the expression of...

300

Low Dose Radiation Research Program: Past Funded Projects-Archive  

NLE Websites -- All DOE Office Websites (Extended Search)

Berkeley, CA A Quantitative Assessment of Bystander Mutagenesis in the Mouse Mammary Gland In Vivo Bruce E. Lehnert Los Alamos National Laboratory, Los Alamos, NM Low Dose...

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Low Dose Radiation Research Program: Quantification of Repair...  

NLE Websites -- All DOE Office Websites (Extended Search)

Quantification of Repair of Low-Dose-Induced DNA Double-Strand Breaks in Diploid Human Cells David Schild Lawrence Berkeley National Laboratory Berkeley, California Why this...

302

Low Dose Radiation | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Radiobiology: Low Dose Radiation Radiobiology: Low Dose Radiation Research Biological and Environmental Research (BER) BER Home About Research Research Abstracts Searchable Archive of BER Highlights External link Biological Systems Science Division (BSSD) Genomic Science DOE Bioenergy Research Centers Radiochemistry & Imaging Instrumentation Radiobiology: Low Dose Radiation Research DOE Human Subjects Protection Program Structural Biology DOE Joint Genome Institute Climate and Environmental Sciences Division (CESD) Facilities Science Highlights Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) News & Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3251 F: (301)

303

ALLDOS: a computer program for calculation of radiation doses from airborne and waterborne releases  

Science Conference Proceedings (OSTI)

The computer code ALLDOS is described and instructions for its use are presented. ALLDOS generates tables of radiation doses to the maximum individual and the population in the region of the release site. Acute or chronic release of radionuclides may be considered to airborne and waterborne pathways. The code relies heavily on data files of dose conversion factors and environmental transport factors for generating the radiation doses. A source inventory data library may also be used to generate the release terms for each pathway. Codes available for preparation of the dose conversion factors are described and a complete sample problem is provided describing preparation of data files and execution of ALLDOS.

Strenge, D.L.; Napier, B.A.; Peloquin, R.A.; Zimmerman, M.G.

1980-10-01T23:59:59.000Z

304

Low Dose Radiation Research Program: Gene Expression Profile...  

NLE Websites -- All DOE Office Websites (Extended Search)

human cDNA clones, we focused on differential gene expression for a low-dose x-ray irradiation at 2cGy and its comparison with high-dose at 4Gy. Four time points were studied at...

305

Low Dose Radiation Research Program: Identification of Mouse Genetic  

NLE Websites -- All DOE Office Websites (Extended Search)

Mouse Genetic Susceptibility to Radiation Carcinogenesis Mouse Genetic Susceptibility to Radiation Carcinogenesis Allan Balmain University of California, San Francisco San Francisco, CA. (Jointly funded by NASA and DOE) Why this Project? To identify pathways that control genetic susceptibility to radiation-induced DNA damage and tumor development using novel developments in genomics together with mouse genetics. Project Goals To identify genetic loci that trigger rapid tumor development of mice after radiation. To characterize new genes at these loci that act as tumor suppressor genes or oncogenes. Experimental Approach New candidate-radiation susceptibility genes will be identified using a unique haplotyping approach. Using DNA from radiation-induced lymphoma, changes in the gene copy number can be detected using BAC microarrays. The

306

Radiation dose assessments to support evaluations of radiological control levels for recycling or reuse of materials and equipment  

Science Conference Proceedings (OSTI)

Pacific Northwest Laboratory is providing Environmental Protection Support and Assistance to the USDOE, Office of Environmental Guidance. Air, Water, and Radiation Division. As part of this effort, PNL is collecting data and conducting technical evaluations to support DOE analyses of the feasibility of developing radiological control levels for recycling or reuse of metals, concrete, or equipment containing residual radioactive contamination from DOE operations. The radiological control levels will be risk-based, as developed through a radiation exposure scenario and pathway analysis. The analysis will include evaluation of relevant radionuclides, potential mechanisms of exposure, and both health and non-health-related impacts. The main objective of this report is to develop a methodology for establishing radiological control levels for recycle or reuse. This report provides the results of the radiation exposure scenario and pathway analyses for 42 key radionuclides generated during DOE operations that may be contained in metals or equipment considered for either recycling or reuse. The scenarios and information developed by the IAEA. Application of Exemption Principles to the Recycle and Reuse of Materials from Nuclear Facilities, are used as the initial basis for this study. The analyses were performed for both selected worker populations at metal smelters and for the public downwind of a smelter facility. Doses to the public downwind were estimated using the US (EPA) CAP88-PC computer code with generic data on atmospheric dispersion and population density. Potential non-health-related effects of residual activity on electronics and on film were also analyzed.

Hill, R.L.; Aaberg, R.L.; Baker, D.A.; Kennedy, W.E. Jr.

1995-07-01T23:59:59.000Z

307

Low Dose Radiation Research Program: James E. Morris  

NLE Websites -- All DOE Office Websites (Extended Search)

Northwest National Laboratories Past Funded Project Sensitivity to radiation-induced cancer in hemachromatosis. Publications Stevens, R.G., Morris, J.E., and Anderson, L.E....

308

Low Dose Radiation Research Program: Walter E. Wilson  

NLE Websites -- All DOE Office Websites (Extended Search)

Monte Carlo simulation of the spatial distribution of energy deposition for an electron microbeam. Radiation Research: 163(4):468472. Mainardi, E., Donahue, R.J.,...

309

Development and characterization of a novel variable low-dose rate irradiator for in vivo mouse studies  

E-Print Network (OSTI)

Radiation exposure of humans generally results in low doses delivered at low dose rate. Our limited knowledge of the biological effects of low dose radiation is mainly based on data from the atomic bomb Life Span Study ...

Davidson, Matthew Allen

310

Lens of Eye Dose Limit Changes: Current Status of the Potential Regulatory Changes and Possible Effects on Radiation Protection Programs at Nuclear Power Plants  

Science Conference Proceedings (OSTI)

Recent research suggests that the threshold for cataract formation as a result of exposure to radiation could be lower than previously considered. The International Commission on Radiological Protection (ICRP) is now recommending a dose limit for the lens of the eye of an average of 20 mSv (2 rem) per year, equivalent to their current recommendation for Total Effective Dose Equivalent (TEDE). The Nuclear Regulatory Commission (NRC) is considering reducing the lens of the eye dose limit to 50 mSv/yr ...

2013-10-29T23:59:59.000Z

311

Mechanism underlying mTOR-associated Protection in Low Dose Radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

low-dose radiation-induced adaptive resistance. Oncogene 27: 6738-6748. 2. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, and Shaw RJ. (2008). AMPK...

312

Thyroid cancer in the Marshallese: relative risk of short-lived internal emitters and external radiation exposure  

Science Conference Proceedings (OSTI)

In a study of the comparative effects of internal versus external irradiation of the thyroid in young people, we determined that the dose from internal irradiation of the thyroid with short-lived internal emitters produced several times less thyroid cancer than did the same dose of radiation given externally. We determined this finding for a group of 85 Marshall Islands children, who were less than 10 years of age at the time of exposure and who were accidentially exposed to internal and external thyroid radiation at an average level of 1400 rad. The external risk coefficient ranged between 2.5 and 4.9 cancers per million person-rad-years at risk, and thus, from our computations, the internal risk coefficient for the Marshallese children was estimated to range between 1.0 and 1.4 cancers per million person-rad-years at risk. In contrast, for individual more than 10 years of age at the time of exposure, the dose from internal irradiation of the thyroid with short-lived internal emitters produced several times more thyroid cancer than did the same dose of radiation given externally. The external risk coefficients for the older age groups were reported in the literature to be in the range of 1.0 to 3.3 cancers per million person-rad-years-at risk. We computed internal risk coefficients of 3.3 to 8.1 cancers per million person-rad-years at risk for adolescent and adult groups. This higher sensitivity to cancer induction in the exposed adolescents and adults, is different from that seen in other exposed groups. 14 refs., 8 tabs.

Lessard, E.T.; Brill, A.B.; Adams, W.H.

1985-01-01T23:59:59.000Z

313

Low dose ionizing radiation (IR) signaling regulation in vivo...  

NLE Websites -- All DOE Office Websites (Extended Search)

studies from our lab indicated that human cells exposed to low doses of IR caused growth stimulation, speeding cells up in their cell cycle division (i.e., checkpoint regulation),...

314

Low Dose Radiation Research Program: Induction of Genomic Instability...  

NLE Websites -- All DOE Office Websites (Extended Search)

genetic backgrounds (BALBcJ and C57BL6J mice) collected at different times post-irradiation (i.e. 1 hr, 4 hrs, 1 month and 6 months). A total of five mice per dose per strain...

315

Low Dose Radiation Research Program: Biological Response of Individual...  

NLE Websites -- All DOE Office Websites (Extended Search)

Response of Individual Cells Following Electron Microbeam Irradiation L. A. Braby and J. R. Ford Texas A&M University, College Station Texas In recent years studies with low doses...

316

Low Dose Radiation Research Program: Techniques and Technology  

NLE Websites -- All DOE Office Websites (Extended Search)

Role of the Number and Spacing of Electron Tracks on the Consequences of Low Dose Irradiation X-ray microfocus source The new X-ray microfocus source Enlarge Image. Melvyn...

317

THE ROLES OF SUPEROXIDE DISMUTAGE (SOD) IN LOW DOSE RADIATION...  

NLE Websites -- All DOE Office Websites (Extended Search)

the detoxifying enzymes may be even more prominent in the case of low-dose, low-LET irradiation, as the majority of genetic damage may be caused by secondary oxidative species. In...

318

Low Dose Radiation Research Program: Impact of Genetic Factors...  

NLE Websites -- All DOE Office Websites (Extended Search)

following paternal F0 137Cs gamma irradiation with doses of 1.0 Gy in CD1 mice. Pilot studies demonstrate effects in at least the F1 generation following paternal F0...

319

A standard dose of radiation for microscopic disease is not appropriate  

SciTech Connect

Elective irradiation of sites of potential occult tumor spread is often part of a patient's radiation therapy program. The required radiation dose (D) depends on the probability that occult disease exists (P(occ)), the number of sites at risk (A), the number of tumor clonogens present (Ni), their radiation sensitivity, and the desired control rate. An exponential model of cell survival is used to quantify the importance of these factors. Control Probability = (1 - Pocc x (1 - e-Ni x (SF2)D/2))A; SF2 = surviving fraction after 2 Gy. Implications for clinical radiation therapy include: 1. Since the number of clonogens in an occult site may vary from 10 degrees to 10(8), Ni is the major determinant of the required dose. The intrinsic radiation sensitivity of the clonogens (SF2) is also extremely important in determining the dose. Other factors are less influential since they vary less. 2. The variability of Ni (8 logs) is larger than the variation in cell number seen with gross disease (1 cm3 versus 1000 cm3, 3 logs). When Ni approximately 10(8), the required dose approaches that needed for small volume gross disease (10(9) cells, 1 cm3). 3. The dose prescribed to elective sites should reflect the risk of occult disease based on the primary tumor site, stage, and grade. 4. Regions where clinicoradiologic evaluation is difficult (e.g., pelvis and obese neck) require higher doses because macroscopic tumor deposits may exist. 5. Relatively low doses (10 to 30 Gy) are often thought to be inadequate for microscopic tumor. However, similar doses have been reported to sterilize microscopic tumor in ovarian, rectal, bladder, breast, and head and neck carcinomas. Relatively low doses should not be discounted since they may be useful in select cases when normal tissue tolerances and/or previous irradiation treatment limit the radiation dose.

Marks, L.B. (Duke Univ. Medical Center, Durham, NC (USA))

1990-12-15T23:59:59.000Z

320

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMANEXPLOSIONS AND MEDICAL RADIATION . Jacob I. Fabrikant, MD,Low Levels of Ionizing Radiation, Yale University School of

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

of the Current State of Radiation Protection Philosophy.Against Pergamon Ionizing Radiation from External Sources,for Protection Against Ionizing Radiation from Supplement to

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

322

Low Dose Radiation Research Program: Howard L. Liber  

NLE Websites -- All DOE Office Websites (Extended Search)

Howard L. Liber Howard L. Liber Department of Environmental and Radiological Health Sciences Colorado State University Currently Funded Projects Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells Technical Abstracts 2003 Workshop: Delayed genomic instability in human lymphoblasts exposed to 137Cs y-rays radiation Schwartz, J.L., Jordan, R., Lenarczyk, M. and Liber, H.L. 2002 Workshop: Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells. Liber, H.L. and Schwartz, J.L. Publications Zhang, Y., Zhou, J., Held, K.D., Redmond, R.W., Prise, K.M., and Liber, H.L. (2008). Deficiencies of double-strand break repair factors and effects on mutagenesis in directly [gamma]-irradiated and medium-mediated bystander human lymphoblastoid cells. Radiation Research 169(2):197-206.

323

Low Dose Radiation Program: Links - Current Issues Involving...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Ionizing Radiation A-Bombs Atomicarchive.com Hiroshima Peace site History of the Atomic Bomb & The Manhattan Project The Atomic Testing Museum The Race to Build the Atomic...

324

Low Dose Radiation Research Program: Gregory A. Kimmel  

NLE Websites -- All DOE Office Websites (Extended Search)

Gregory A. Kimmel Gregory A. Kimmel Pacific Northwest National Laboratory Past Project A Novel Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation. Technical Abstracts 2002 Workshop: Spatially Resolved Single Cell Irradiator to Study Bystander Responses to Low LET Radiation. Resat, M.S., Kimmel, G.A., Miller, J.H., McDonald, J.C., Murphy, M.K., Strom, D.J., Thrall, B.D., and Colson, S.D. 2001 Workshop: Spatially Resolved Single Cell Irradiator to Study Bystander Responses to Low LET Radiation. Resat, M.S., Kimmel, G.A., Miller, J.H., McDonald, J.C., Murphy, M.K., Strom, D.J., Thrall, B.D., Metting, N.F., and Colson, S.D 1999 Workshop: A Novel, Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation.

325

An integrated genetics approach to systemic low-dose radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

mammary tumor formation by combining our genetic diverse mouse model with the mammary gland radiation chimera model pioneered in the Barcellos-Hoff laboratory (3,4). As it takes...

326

Low Dose Radiation Research Program: Delayed Genomic Instability...  

NLE Websites -- All DOE Office Websites (Extended Search)

Lymphoblasts Exposed to 137Cs y-rays Radiation Authors: Jeffrey L. Schwartzb, Robert Jordan,b, Marek Lenarczyk,a and Howard L. Libera Institutions: a Department of Environmental...

327

Annual report shows potential INL radiation doses well below...  

NLE Websites -- All DOE Office Websites (Extended Search)

than 1% of the limit of 10 mrem established by the EPA and is about 2% of the amount of radiation a person receives during a dental x-ray. In comparison, according to the U.S....

328

Low Dose Radiation Research Program: Monte Carlo Track Structure...  

NLE Websites -- All DOE Office Websites (Extended Search)

Monte Carlo Track Structure Simulations for Low-LET Selected Cell Radiation Studies Walt Wilson Washington State University Tri-Cities Why This Project There are many types of...

329

REGULATORY GUIDE 8.13 (Draft was issued as DG-8014) INSTRUCTION CONCERNING PRENATAL RADIATION EXPOSURE  

E-Print Network (OSTI)

Inspection and Investigations, in Section 19.12, Instructions to Workers, requires instruction in the health protection problems associated with exposure to radiation and/or radioactive material, in precautions or procedures to minimize exposure, and in the purposes and functions of protective devices employed. The

unknown authors

1999-01-01T23:59:59.000Z

330

Video Camera Use at Nuclear Power Plants: Tools for Increasing Productivity and Reducing Radiation Exposure: Tools for Increasing Pr oductivity and Reducing Radiation Exposure  

Science Conference Proceedings (OSTI)

Nuclear power plants have increased the use of industrial video cameras as support tools for a variety of plant operations and outage tasks. This survey on utility use of video cameras, the equipment being used, and the benefits derived found that the video camera is an important tool for reducing radiation exposure and improving productivity through more efficient use of personnel.

1990-08-14T23:59:59.000Z

331

Effects of low-dose radiation on immune cell function using genetic and  

NLE Websites -- All DOE Office Websites (Extended Search)

low-dose radiation on immune cell function using genetic and low-dose radiation on immune cell function using genetic and metabolomics approaches Henghong Li Georgetown University Abstract The objectives of this study are to investigate acute and persistent effects of ionizing radiation and space radiation on immune cell subsets and function. The role(s) for p38 MAP kinase in such radiation responses is being investigated using a genetic approach where an engineered mouse line has had one wt p38α gene replaced with a dominantnegative mutant (p38α+/DN). T cells are one of the most radiosensitive cell types in vivo, and radiation is known to impact CD4 T cell function long term. T cells are normally activated by antigen, which triggers differentiation to specific subsets involving various cytokines. In addition, T cells have a

332

Radiation and litigation : analyses of the ALARA principle and low dose radiation in the courts, and the future of radiation in court cases  

E-Print Network (OSTI)

Currently there are a growing number of radiation workers. In order to ensure the safety of the employees, regulations have been established by the federal government and state governments to limit the dose equivalent to ...

Esparza, Enrique

2006-01-01T23:59:59.000Z

333

Low Dose Radiation Research Program: Studies of Low-Dose Bystander...  

NLE Websites -- All DOE Office Websites (Extended Search)

Low-Dose Bystander Effects Using a Focused Soft X-ray Microprobe Kevin M. Prise1, Melvyn Folkard1, Giuseppe Schettino1, Elena Rusyn2, Heidi C. Newman1, Kathryn D. Held2 and Barry...

334

Literature Highlight: Radiation Exposure to the Heart and the Risk of Ischemic Heart Disease  

E-Print Network (OSTI)

, fish, and olive oil.1-4 This diet discourages dairy products, saturated fats, and red meats.1-4 Older have helped to limit radiation exposure to unaffected tissues, radiation expo- sure to the heart may benefit from an -linolenic acid-rich Mediterranean diet which emphasizes bread, fruits, nuts, vegetables

Vonessen, Nikolaus

335

Environmental Radiation Doses From Difficult-to-Measure Nuclides  

Science Conference Proceedings (OSTI)

Nuclear power plants release numerous radionuclides to the environment, but evaluating the significance of the environmental dose from these nuclides is difficult. The simplified methodology developed in this research makes this assessment easier and can also help environmental engineers design appropriate monitoring programs.

1985-01-14T23:59:59.000Z

336

Low Dose Radiation Research Program: Modeling Intercellular Interactions  

NLE Websites -- All DOE Office Websites (Extended Search)

Modeling Intercellular Interactions During Radiation Carcinogenesis Modeling Intercellular Interactions During Radiation Carcinogenesis Authors: Rainer K Sachs,1 Michael Chan,2 Lynn Hlatky,3 Philip Hahnfeldt3 Institutions: 1Departments of Mathematics and Physics, University of California Berkeley California; 2School of Medicine, University of California at San Diego, La Jolla California; 3Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston Massachusetts Abstract By modulating the microenvironment of malignant or pre-malignant epithelial cells, inhibitory or stimulatory signals from nearby cells, including those in stromal and vascular tissues, can play a key role in carcinogenesis; cancer is ultimately a disease of a whole-cell community, not just of a single cell, clone, or cell lineage. However, current commonly used

337

Low Dose Radiation Program: Links - Suggested Books and Literature for  

NLE Websites -- All DOE Office Websites (Extended Search)

Suggested Books and Literature for Teachers about Radiation Suggested Books and Literature for Teachers about Radiation Popular Press News Articles Newspapers is an excellent portal or gateway to newspapers from all 50 states. To find a newspaper of interest, select a state and click Search. For a more specified search, fill in the Title of the newspaper and click Search. The newspapers available from that state are listed alphabetically. Hall, E., Radiation and Life Hall, E.J.Radiobiology for the Radiologist. 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA. 2000 Nagai, T.Atomic Bomb Rescue and Relief Report. Nagasaki Association for Hibakushas' Medical Care (NASHIM), Nagasaki, Japan. 2000 Nagataki, S.Nagasaki Symposium on Chernobyl: Update and Future, Proceedings of "Chernobyl Update" 3 June 1994 at the 67th Annual Meeting of

338

Low Dose Radiation Research Program: Interaction between Tissue and  

NLE Websites -- All DOE Office Websites (Extended Search)

between Tissue and Cellular Stress Responses: Effect of between Tissue and Cellular Stress Responses: Effect of TGF-ß Depletion on Radiation-Induced p53 Response M.H. Barcellos-Hoff, S.A. Ravani, R.L. Henshall, K.B. Ewan, R.L. Warters,* B. Parvin Lawrence Berkeley National Laboratory *University of Utah One of the most widely studied cellular responses to radiation is the activation of the transcription factor, p53, whose abundance and action dictates individual cellular fate decisions regarding proliferation, differentiation and death. A cell's response to damage needs to be rapid. Thus, it is not surprising that the activation of the p53 stress response primarily involves post-translational changes in the p53 protein. Whereas intracellular radiation-induced mediators of p53 stability have been the subject of intense study, little is known about the extracellular factors

339

Low Dose Radiation Research Program: Interaction of Genome and Cellular  

NLE Websites -- All DOE Office Websites (Extended Search)

of Genome and Cellular Micronenvioronment of Genome and Cellular Micronenvioronment Mina Bissell Life Sciences Division Lawrence Berkeley National Laboratory Why this Project While normal stoma can delay or prevent tumorigenesis, abnormal stromal components can promote tumor growth. Acquired or inherited mutations that alter stromal cell function can release the context-suppressed malignant cells. Literature spanning more than a century has shown that inflammation associated with tissue wounding can produce tunors. Radiation produces changes in reactive oxygen that are similar to inflammation and may represent a mechanism for radiation-induced damage. Project Goals To determine the underlying role of stromal alterations in controling genomic instability accompanying epithelial-mesenchyumal transformation.

340

Low Dose Radiation Research Program: Mary Helen Barcellos-Hoff - 2003  

NLE Websites -- All DOE Office Websites (Extended Search)

DOE Low Dose Radiation Program Workshop IV DOE Low Dose Radiation Program Workshop IV Abstract Title: TGF-β Protects Human Mammary Epithelial Cells from Radiation-Induced Centrosome Amplification Authors: Mary Helen Barcellos-Hoff, Bahram Parvin, Anna C. Erickson and Rishi Gupta Institutions: Department of Cell and Molecular Biology, Life Sciences Division, Ernest Orlando Lawrence, Berkeley National Laboratory, Berkeley, California In recent studies we have shown that ionizing radiation (IR), a known carcinogen of human and murine mammary gland, compromises human mammary epithelial cell (HMEC) polarity and multicellular organization in a manner characteristic of neoplastic progression through a heritable, non-mutational mechanism (1). Thus, when all cells are irradiated with a significant dose (2 Gy), the daughters of irradiated cells lose their

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Low Dose Radiation Research Program: Dual Regulation of JB6 Transformation  

NLE Websites -- All DOE Office Websites (Extended Search)

Dual Regulation of JB6 Transformation by Low Dose Gamma Radiation. Dual Regulation of JB6 Transformation by Low Dose Gamma Radiation. Authors: Thomas J. Weber,1 Lye M. Markillie,1 William B. Chrisler,1 Xingye C. Lei,1 and Nancy H. Colburn2 Institutions: 1Molecular Biosciences, Pacific Northwest National Laboratory. 2Gene Regulation Section, Basic Research Laboratory, National Cancer Institute JB6 mouse epidermal cells have been instrumental in defining the molecular mechanisms associated with neoplastic transformation in response to known tumor promoters. JB6 cells exhibit a clonal growth response to oxygen free radicals suggesting this model may also be useful for radiation research. Treatment of JB6 cells with 2 and 20 cGy gamma radiation resulted in a weak, but dose-dependent increase in anchorage-independent growth observed

342

Low Dose Program Highlight: Do Heritable Differences in an Individual...  

NLE Websites -- All DOE Office Websites (Extended Search)

Differences in an Individual's Immune System Predict Differential Sensitivity to Low Dose Radiation Exposure? Brynn Voy, University of Tennessee Knoxville, and Oak Ridge...

343

Composite radiation dose representation using Fuzzy Set theory  

Science Conference Proceedings (OSTI)

Composite plans created from different image sets are generated through Deformable Image Registration (DIR) and present a challenge in accurately presenting uncertainties, which vary with anatomy. Our effort focuses on the application of Fuzzy Set theory ... Keywords: Composite plan, Deformable image registration, Fuzzy Set, Radiation therapy

Samuel B. Park; James I. Monroe; Min Yao; Mitchell Machtay; Jason W. Sohn

2012-03-01T23:59:59.000Z

344

Radiation and Uranium Resources Exposure Control (South Dakota)  

Energy.gov (U.S. Department of Energy (DOE))

The public policy of South Dakota is to encourage the constructive uses of radiation, the proper development of uranium resources, and the control of any associated harmful effects. The disposal of...

345

Low Dose Radiation Research Program: Molecular Mechanisms of  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells Howard L. Liber Department of Environmental and Radiological Health Sciences Colorado State University Why This Project This research will be to investigate the condition known as genomic instability. This can be defined as a state in which genetic alterations, including chromosome aberrations and gene mutations, occur at rates that are much higher than normal. In fact, genomic instability is what allows a normal cell to accumulate the multiple genetic alterations that are required to convert it into a cancer cell. The chromosomes of human cells have structures at their ends called telomeres. Telomeres normally function to prevent chromosomes from fusing together end-to-end. An important

346

Low Dose Radiation Research Program: The Progeny of Irradiated Mammary  

NLE Websites -- All DOE Office Websites (Extended Search)

Progeny of Irradiated Mammary Epithelial Cells Exhibit a Phenotype Progeny of Irradiated Mammary Epithelial Cells Exhibit a Phenotype Characteristic of Malignancy Mary H. Barcellos-Hoff, R.L. Henshall-Powell, M.J. Bissell, and B. Parvin Lawrence Berkeley National Laboratory, Life Sciences Division We have proposed that the ability of radiation to induce altered microenvironments affects the frequency and features of neoplastic progression. Thus, we have sought to characterize the irradiated microenvironment and determine how these events contribute to mammary carcinogenesis. By using imaging bioinformatics to analyze mouse and human models of breast cancer we have now examined cell adhesion molecules (CAMs) critical for tissue-specific organization and function. We found that 1) radiation-induced microenvironments can contribute to neoplastic potential

347

Light scattering apparatus and method for determining radiation exposure to plastic detectors  

DOE Patents (OSTI)

An improved system and method of analyzing cumulative radiation exposure registered as pits on track etch foils of radiation dosimeters. The light scattering apparatus and method of the present invention increases the speed of analysis while it also provides the ability to analyze exposure levels beyond that which may be properly measured with conventional techniques. Dosimeters often contain small plastic sheets that register accumulated damage when exposed to a radiation source. When the plastic sheet from the dosimeter is chemically etched, a track etch foil is produced wherein pits or holes are created in the plastic. The number of these pits, or holes, per unit of area (pit density) correspond to the amount of cumulative radiation exposure which is being optically measured by the apparatus. To measure the cumulative radiation exposure of a track etch foil a high intensity collimated beam is passed through foil such that the pits and holes within the track etch foil cause a portion of the impinging light beam to become scattered upon exit. The scattered light is focused with a lens, while the primary collimated light beam (unscattered light) is blocked. The scattered light is focused by the lens onto an optical detector capable of registering the optical power of the scattered light which corresponds to the cumulative radiation to which the track etch foil has been exposed.

Hermes, Robert E. (White Rock, NM)

2002-01-01T23:59:59.000Z

348

Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation Deok-Jin Jang 1 , Mingquan Guo 1 , Julia S.F.Chu 2 , Kyle T. Kurpinski 2 , Bjorn Rydberg 1 , Song Li 2 , and Daojing Wang 1 1. Life Sciences Division, Lawrence Berkeley National Lab, Berkeley, CA 94720 2. Department of Bioengineering, University of California, Berkeley, CA 94720 We will present data obtained during the first year of our DOE/NASA Low Dose Radiation Research program. We utilized a comprehensive approach including transcriptomics, proteomics, phosphoproteomics, and biochemistry to characterize human mesenchymal stem cells (MSCs) in response to low dose ionizing radiation. We first determined the cell survival, proliferation, and osteogenic differentiation of

349

Investigation of non-targeted effects of low dose ionizing radiation on the mammary gland  

NLE Websites -- All DOE Office Websites (Extended Search)

non-targeted effects of low dose ionizing radiation on the mammary gland non-targeted effects of low dose ionizing radiation on the mammary gland utilizing three-dimensional culture models of mammary cells derived from mouse strains that differ in susceptibility to tumorigenesis Joni D. Mott, Antoine M. Snijders, Alvin Lo, Dinah Levy-Groesser, Bahram Parvin, Andrew J. Wyrobek, Jian-Hua Mao, and Mina J. Bissell Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley CA 94720 Goal: Within the Lawrence Berkeley National Laboratory's SFA, Project 2, our studies focus on utilizing three dimensional (3D) cell culture models as surrogates for in vivo studies to determine how low doses of ionizing radiation influence mammary gland tissue architecture and how this may relate both to tumor progression and/or adaptive response.

350

Calculation of radiation therapy dose using all particle Monte Carlo transport  

DOE Patents (OSTI)

The actual radiation dose absorbed in the body is calculated using three-dimensional Monte Carlo transport. Neutrons, protons, deuterons, tritons, helium-3, alpha particles, photons, electrons, and positrons are transported in a completely coupled manner, using this Monte Carlo All-Particle Method (MCAPM). The major elements of the invention include: computer hardware, user description of the patient, description of the radiation source, physical databases, Monte Carlo transport, and output of dose distributions. This facilitated the estimation of dose distributions on a Cartesian grid for neutrons, photons, electrons, positrons, and heavy charged-particles incident on any biological target, with resolutions ranging from microns to centimeters. Calculations can be extended to estimate dose distributions on general-geometry (non-Cartesian) grids for biological and/or non-biological media.

Chandler, William P. (Tracy, CA); Hartmann-Siantar, Christine L. (San Ramon, CA); Rathkopf, James A. (Livermore, CA)

1999-01-01T23:59:59.000Z

351

Dosimetry in steep dose-rate gradient radiation fields: A challenge in clinical applications  

Science Conference Proceedings (OSTI)

The fundamental goal of radiotherapy is to reduce the damage to normal tissue and optimize the dose to the tumor with an associated high probability of cure. Because of this, an accurate and precise knowledge of the radiation dose distribution delivered around the tumor volume during radiotherapy treatments such as stereotactic radiosurgery, intensity modulated radiotherapy or brachytherapy with low-energy X-ray and beta particle sources is of great importance. However, in each of these radiation fields, there exists a steep dose-rate gradient which makes it very difficult to perform accurate dose measurements. In this work, the physics phenomena involved in the energy absorption for each of these situations are discussed, and a brief revision of what the Medical Physics community is doing is presented.

Massillon-JL, G. [Instituto de Fisica, Universidad Nacional Autonoma de Mexico, A.P. 20-364, 01000 DF (Mexico)

2010-12-07T23:59:59.000Z

352

Low Dose Radiation Research Program: Funded Project Descriptions  

NLE Websites -- All DOE Office Websites (Extended Search)

Funded Project Descriptions Funded Project Descriptions Non-Invasive Early Detection and Molecular Analysis of Low X-Ray Dose Effects in the Lens Jointly funded by NASA and DOE Principal Investigator: Lee Goldstein, M.D., Ph.D., Associate Professor in Psychiatry, Neurology, Ophthalmology, Pathology and Laboratory Medicine, & Biomedical Engineering, Boston University’s School Medicine, College of Engineering, and Photonics Center. Boston, Ma. The project includes a new DOE FWP (~$400 K over 3 years) to Lawrence Berkeley National Laboratory with Eleanor Blakely as Project Leader. The work includes a subcontract to support the collaboration of Polly Chang of SRI, International, Menlo Park, CA. and is scheduled to begin as early as August 2009. This proposal was submitted in response to the joint DOE/NASA

353

RADIATION DOSE ASSESSMENT FOR THE BIOTA OF TERRESTRIAL ECOSYSTEMS IN THE SHORELINE ZONE OF THE CHERNOBYL NUCLEAR POWER PLANT COOLING POND  

Science Conference Proceedings (OSTI)

Radiation exposure of the biota in the shoreline area of the Chernobyl Nuclear Power Plant Cooling Pond was assessed to evaluate radiological consequences from the decommissioning of the Cooling Pond. The article addresses studies of radioactive contamination of the terrestrial faunal complex and radionuclide concentration ratios in bodies of small birds, small mammals, amphibians, and reptiles living in the area. The data were used to calculate doses to biota using the ERICA Tool software. Doses from {sup 90}Sr and {sup 137}Cs were calculated using the default parameters of the ERICA Tool and were shown to be consistent with biota doses calculated from the field data. However, the ERICA dose calculations for plutonium isotopes were much higher (2-5 times for small mammals and 10-14 times for birds) than the doses calculated using the experimental data. Currently, the total doses for the terrestrial biota do not exceed maximum recommended levels. However, if the Cooling Pond is allowed to drawdown naturally and the contaminants of the bottom sediments are exposed and enter the biological cycle, the calculated doses to biota may exceed the maximum recommended values. The study is important in establishing the current exposure conditions such that a baseline exists from which changes can be documented following the lowering of the reservoir water. Additionally, the study provided useful radioecological data on biota concentration ratios for some species that are poorly represented in the literature.

Farfan, E.; Jannik, T.

2011-10-01T23:59:59.000Z

354

Low Dose Radiation Research Program: Quantitative Analysis of Connexin  

NLE Websites -- All DOE Office Websites (Extended Search)

Quantitative Analysis of Connexin Expression in Cultured Colonies Quantitative Analysis of Connexin Expression in Cultured Colonies Authors: B. Parvin, Q. Yang, R. L. Henshall-Powell and M.H. Barcellos Hoff We are studying the effects of ionizing radiation on the signaling between human mammary epithelial cells and the extracellular microenvironment. To do so we use an assay based on the ability of the cells to organize into three-dimensional acini when embedded into an extracellular matrix. Although tumorigenic and non-tumorigenic mammary epithelial cells are nearly indistinguishable when cultured as monolayers, their biological character readily diverge when tissue-specific morphogenesis is analyzed. Non-malignant human mammary epithelial cells (HMEC) cultured within a reconstituted basement membrane organize into acinar-like structures with

355

Low Dose Radiation Research Program: Research Highlights - Real-time  

NLE Websites -- All DOE Office Websites (Extended Search)

Real-time imaging of repair processes possible with Nickel-63 Real-time imaging of repair processes possible with Nickel-63 microirradiator Microscope Microscope stage-mounted microirradiation system. (A) Overall system shown mounted on a micromanipulator housed within a heated, humidified, environmental chamber of a microscope. (B) Close-up showing attachment of device to the micromanipulator. (C) Detail showing the bend in the enclosing capillary, which allows positioning of the active surface directly above the target cell. (D) Microirradiator tip in dissecting microscope. (E) Close-up view through microscope optics (scale bar, 10 microns.) Background: Scientists know that mammalian cells begin a nucleoplasmic repair process within seconds after being exposed to ionizing radiation. Real-time imaging of this process could further understanding of the

356

An integrated genetics approach to systemic low-dose radiation responses  

NLE Websites -- All DOE Office Websites (Extended Search)

integrated genetics approach to systemic low-dose radiation responses integrated genetics approach to systemic low-dose radiation responses G. Huang 1 , Y. Huang 1 , D.H. Nguyen 1 , K. Bjornstad 1 , C. Rosen 1 , P. Chang 2 , R. DelRosario 3 , Do Yup Lee 1 , B. Bowen 1 , W. Reindl 1 , J. Mott 1 , A. Balmain 3 , M.H. Barcellos-Hoff 4 , Joe W Gray 1,5 , Mina Bissell 1 , Gary Karpen 1 , T. Northen 1 , E. A. Blakely 1 , J. H. Mao 1 1 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 2 SRI International, Menlo Park, CA

357

SHP-2 tyrosine phosphate-dependent focal adhesion kinase mediated cell migration of primary endothelial cells upon low LET radiation exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

SHP-2 tyrosine phosphate-dependent focal adhesion kinase mediated cell SHP-2 tyrosine phosphate-dependent focal adhesion kinase mediated cell migration of primary endothelial cells upon low LET radiation exposure Xiangpeng Zheng, 1 Sumathy Mohan, 3 and Mohan Natarajan 1,2 Departments of 1 Otolaryngology, 2 Radiation Oncology, and 3 Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 The influence and mechanism of low LET radiation exposure on wound healing process is not yet fully understood. Based on the vital role of endothelial cells in migration and wound healing, this study investigated the response of endothelial cells to low-dose irradiation and the underlying mechanism. A wound was inflicted in the confluent monolayer of primary vascular endothelial cells exposing a cell-free zone on the plate. The cells were then exposed

358

Occupational Radiation Exposure at Commercial Nuclear Power Reactors and Other Facilities 2010, Prepared for the Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, May 2012  

SciTech Connect

This report summarizes the occupational exposure data that are maintained in the U.S. Nuclear Regulatory Commissions (NRC) Radiation Exposure Information and Reporting System (REIRS). The bulk of the information contained in the report was compiled from the 2010 annual reports submitted by five of the seven categories of NRC licensees subject to the reporting requirements of 10 CFR 20.2206. Because there are no geologic repositories for high-level waste currently licensed and no NRC-licensed low-level waste disposal facilities currently in operation, only five categories will be considered in this report. The annual reports submitted by these licensees consist of radiation exposure records for each monitored individual. These records are analyzed for trends and presented in this report in terms of collective dose and the distribution of dose among the monitored individuals. Annual reports for 2010 were received from a total of 190 NRC licensees. The summation of reports submitted by the 190 licensees indicated that 192,424 individuals were monitored, 81,961 of whom received a measurable dose. When adjusted for transient workers who worked at more than one licensee during the year, there were actually 142,471 monitored individuals and 62,782 who received a measurable dose. The collective dose incurred by these individuals was 10,617 person-rem, which represents a 12% decrease from the 2009 value. This decrease was primarily due to the decrease in collective dose at commercial nuclear power reactors, as well as a decrease in the collective dose for most of the other categories of NRC licensees. The number of individuals receiving a measurable dose also decreased, resulting in an average measurable dose of 0.13 rem for 2010. The average measurable dose is defined as the total effective dose equivalent (TEDE) divided by the number of individuals receiving a measurable dose. In calendar year 2010, the average annual collective dose per reactor for light water reactor (LWR) licensees was 83 person-rem. This represents a 14% decrease from the value reported for 2009 (96 person-rem). The decrease in collective dose for commercial nuclear power reactors was due to an 11% decrease in total outage hours in 2010. During outages, activities involving increased radiation exposure such as refueling and maintenance are performed while the reactor is not in operation. The average annual collective dose per reactor for boiling water reactors (BWRs) was 137 personrem for 35 BWRs, and 55 person-rem for 69 pressurized water reactors (PWRs). Analyses of transient individual data indicate that 29,333 individuals completed work assignments at two or more licensees during the monitoring year. The dose distributions are adjusted each year to account for the duplicate reporting of transient individuals by multiple licensees. The adjustment to account for transient individuals has been specifically noted in footnotes in the figures and tables for commercial nuclear power reactors. In 2010, the average measurable dose per individual for all licensees calculated from reported data was 0.13 rem. Although the average measurable dose per individual from data submitted by licensees was 0.13 rem, a corrected dose distribution resulted in an average measurable dose per individual of 0.17 rem.

D. E. Lewis D. A. Hagemeyer Y. U. McCormick

2012-07-07T23:59:59.000Z

359

Occupational radiation exposure history of Idaho Field Office Operations at the INEL  

Science Conference Proceedings (OSTI)

An extensive review has been made of the occupational radiation exposure records of workers at the Idaho National Engineering Laboratory (INEL) over the period of 1951 through 1990. The focus has been on workers employed by contractors and employees of the Idaho Field Operations Office (ID) of the United States Department of Energy (USDOE) and does not include the Naval Reactors Facility (NRF), the Argonne National Laboratory (ANL), or other operations field offices at the INEL. The radiation protection guides have decreased from 15 rem/year to 5 rem/year in 1990 for whole body penetrating radiation exposure. During these 40 years of nuclear operations (in excess of 200,000 man-years of work), a total of twelve individuals involved in four accidents exceeded the annual guidelines for exposure; nine of these exposures were received during life saving efforts on January 3, 1961 following the SL-1 reactor accident which killed three military personnel. These exposures ranged from 8 to 27 rem. Only one individual has exceeded the annual whole body penetrating radiation protection guidelines in the last 29 years.

Horan, J.R.; Braun, J.B.

1993-10-01T23:59:59.000Z

360

Exposure to ionizing radiation in the emergency department from commonly performed portable radiographs  

SciTech Connect

To accurately assess the potential hazard of exposure to ionizing radiation from portable radiographs taken in the emergency department, a study was performed to measure such radiation at different distances from the edge of an irradiated field during portable cervical-spine (pC-S), portable chest radiograph (pCXR), and portable anteroposterior-pelvis (pAP-pelvis) radiographs. For all three types of portable radiographs, radiation exposure is a function of distance from the beam. However, at 40 cm (15 inches) away from the beam during a pC-S or pCXR and at 160 cm (63 inches) from a pAP-pelvis film, exposure is minimal. At these distances one would need to be exposed to more than 1,200 such radiographs to equal background environmental ionizing radiation. Medical personnel should not have to leave a patient care area for fear of undue acute and chronic radiation exposure while portable radiographs are performed in the ED. By using protective garments and standing appropriate distances away from the patient, continuous patient care can be maintained while portable radiographs are taken in the ED.

Grazer, R.E.; Meislin, H.W.; Westerman, B.R.; Criss, E.A.

1987-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "dose radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

MO?F?103?01: Estimating Risk of Low Radiation Doses  

Science Conference Proceedings (OSTI)

Several articles in the medical literature over the past few years have predicted thousands of cancers and cancer deaths annually in the US population caused by radiation exposures from medical imaging. The predictions are derived from risk estimates in the National Academy of Sciences BEIR VII report. These risk estimates are highly speculative with wide confidence intervals

2013-01-01T23:59:59.000Z

362

Radiosensitization of Human Cervical Cancer Cells by Inhibiting Ribonucleotide Reductase: Enhanced Radiation Response at Low-Dose Rates  

Science Conference Proceedings (OSTI)

Purpose: To test whether pharmacologic inhibition of ribonucleotide reductase (RNR) by 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC no. 663249) enhances radiation sensitivity during low-dose-rate ionizing radiation provided by a novel purpose-built iridium-192 cell irradiator. Methods and Materials: The cells were exposed to low-dose-rate radiation (11, 23, 37, 67 cGy/h) using a custom-fabricated cell irradiator or to high-dose-rate radiation (330 cGy/min) using a conventional cell irradiator. The radiation sensitivity of human cervical (CaSki, C33-a) cancer cells with or without RNR inhibition by 3-AP was evaluated using a clonogenic survival and an RNR activity assay. Alteration in the cell cycle distribution was monitored using flow cytometry. Results: Increasing radiation sensitivity of both CaSki and C33-a cells was observed with the incremental increase in radiation dose rates. 3-AP treatment led to enhanced radiation sensitivity in both cell lines, eliminating differences in cell cytotoxicity from the radiation dose rate. RNR blockade by 3-AP during low-dose-rate irradiation was associated with low RNR activity and extended G{sub 1}-phase cell cycle arrest. Conclusions: We conclude that RNR inhibition by 3-AP impedes DNA damage repair mechanisms that rely on deoxyribonucleotide production and thereby increases radiation sensitivity of human cervical cancers to low-dose-rate radiation.

Kunos, Charles A., E-mail: charles.kunos@UHhospitals.org [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Colussi, Valdir C. [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Pink, John [Department of General Medical Sciences, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Radivoyevitch, Tomas [Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Oleinick, Nancy L. [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States)

2011-07-15T23:59:59.000Z

363

ORISE Resources: Population Monitoring in Radiation Emergencies  

NLE Websites -- All DOE Office Websites (Extended Search)

into the body Removal of external or internal contamination (decontamination) Radiation dose received and the resulting health risk from the exposure Long-term health...

364

Review and Evaluation of Updated Research on the Health Effects Associated with Low-Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

Potential health effects of low levels of radiation have predominantly been based on those effects observed at high levels of radiation. The authors have reviewed more than 200 percent publications in radiobiology and epidermiology related to low dose radiation and concluded that recent radiobiological studies at low-doses; that doses low dose radiation research should to holistic, systems-based approaches to develop models that define the shape of the dose-response relationships at low doses; and that these results should be combined with the latest epidermiology to produce a comprehensive understanding of radiation effects that addresses both damage, likely with a linear effect, and response, possibly with non-linear consequences.

Dauer, Lawrence T.; Brooks, Antone L.; Hoel, David G.; Morgan, William F.; Stram, Daniel; Tran, Phung

2010-07-01T23:59:59.000Z

365

DOI: 10.2203/dose-response.10-003.Cuttler COMMENTARY ON USING LNT FOR RADIATION PROTECTION AND RISK ASSESSMENT  

E-Print Network (OSTI)

? An article by Jerome Puskin attempts to justify the continued use of the linear nothreshold (LNT) assumption in radiation protection and risk assessment. In view of the substantial and increasing amount of data that contradicts this assumption; it is difficult to understand the reason for endorsing this unscientific behavior, which severely constrains nuclear energy projects and the use of CT scans in medicine. Many Japanese studies over the past 25 years have shown that low doses and low dose rates of radiation improve health in living organisms including humans. Recent studies on fruit flies have demonstrated that the original basis for the LNT notion is invalid. The Puskin article omits any mention of important reports from UNSCEAR, the NCRP and the French Academies of Science and Medicine, while citing an assessment of the Canadian breast cancer study that manipulated the data to obscure evidence of reduced breast cancer mortality following a low total dose. This commentary provides dose limits that are based on real human data, for both single and chronic radiation exposures. Jerome Puskins perspective on the use of the linear no-threshold (LNT) assumption for radiation protection and risk assessment (Puskin

unknown authors

2010-01-01T23:59:59.000Z

366

A PORTABLE DOSE RATE INSTRUMENT FOR MEASUREMENT OF NATURAL BACK-GROUND RADIATION LEVELS  

SciTech Connect

An instrument of the ionization chamber type which is capable of measuring radiation dose rates down to and below those encountered in natural background was designed and constructed. It consists of a 40-liter ionization chamber coupled to a portable battery-powered electrometer. The chamber polarizing battery is a part of the chamber center electrode assembly and is located inside the chamber. (auth)

Rising, F.L.

1960-12-19T23:59:59.000Z

367

Low Dose Radiation Research Program: Genetic Control of Repair and Adaptive  

NLE Websites -- All DOE Office Websites (Extended Search)

Repair and Adaptive Responses to Low-level DNA Damage Repair and Adaptive Responses to Low-level DNA Damage James E. Haber Brandeis University Why This Project In order to fully understand mechanisms resulting in effects of low dose, whole system rather than cells must be examined. Although not identical to mammalian systems, simple systems usually have many similarities and give direction for further study of more complex systems. We use the budding yeast, Saccharomyces cerevisiae, as a model system because it is easy to manipulate and its genome is simple and well characterized. Project Goals Examine mechanisms and effects of low dose radiation response for: Genetic recombination mechanisms that lead to genomic instability Genetic factors that affect individual susceptibility to low-dose radiation The adaptive response

368

Low Dose Radiation Research Program: Mechanisms of Tissue Response to Low  

NLE Websites -- All DOE Office Websites (Extended Search)

Tissue Response to Low Dose Radiation Tissue Response to Low Dose Radiation Mary Helen Barcellos-Hoff Lawrence Berkeley National Laboratory Why This Project? In the past, the effects of ionizing radiation on humans has been attributed in great part to its ability to damage DNA, which transmits information from cell to cell, and generation to generation. Damaged DNA can lead to cell death or perpetuate the damage to daughter cells and to future generations. In addition to the information contained with the genome (i.e., DNA sequence), information directing cell behavior and tissue function is also stored outside the DNA. The success in cloning sheep from the DNA contained in the nucleus of an adult cell shows how important signals from the outside are in defining how the genome is expressed. This

369

Dose Constraints to Prevent Radiation-Induced Brachial Plexopathy in Patients Treated for Lung Cancer  

Science Conference Proceedings (OSTI)

Purpose: As the recommended radiation dose for non-small-cell lung cancer (NSCLC) increases, meeting dose constraints for critical structures like the brachial plexus becomes increasingly challenging, particularly for tumors in the superior sulcus. In this retrospective analysis, we compared dose-volume histogram information with the incidence of plexopathy to establish the maximum dose tolerated by the brachial plexus. Methods and Materials: We identified 90 patients with NSCLC treated with definitive chemoradiation from March 2007 through September 2010, who had received >55 Gy to the brachial plexus. We used a multiatlas segmentation method combined with deformable image registration to delineate the brachial plexus on the original planning CT scans and scored plexopathy according to Common Terminology Criteria for Adverse Events version 4.03. Results: Median radiation dose to the brachial plexus was 70 Gy (range, 56-87.5 Gy; 1.5-2.5 Gy/fraction). At a median follow-up time of 14.0 months, 14 patients (16%) had brachial plexopathy (8 patients [9%] had Grade 1, and 6 patients [7%] had Grade {>=}2); median time to symptom onset was 6.5 months (range, 1.4-37.4 months). On multivariate analysis, receipt of a median brachial plexus dose of >69 Gy (odds ratio [OR] 10.091; 95% confidence interval [CI], 1.512-67.331; p = 0.005), a maximum dose of >75 Gy to 2 cm{sup 3} of the brachial plexus (OR, 4.909; 95% CI, 0.966-24.952; p = 0.038), and the presence of plexopathy before irradiation (OR, 4.722; 95% CI, 1.267-17.606; p = 0.021) were independent predictors of brachial plexopathy. Conclusions: For lung cancers near the apical region, brachial plexopathy is a major concern for high-dose radiation therapy. We developed a computer-assisted image segmentation method that allows us to rapidly and consistently contour the brachial plexus and establish the dose limits to minimize the risk of brachial plexopathy. Our results could be used as a guideline in future prospective trials with high-dose radiation therapy for unresectable lung cancer.

Amini, Arya [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); University of California Irvine School of Medicine, Irvine, California (United States); Yang Jinzhong; Williamson, Ryan [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); McBurney, Michelle L. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Erasmus, Jeremy [Department of Diagnostic Imaging, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Allen, Pamela K.; Karhade, Mandar; Komaki, Ritsuko; Liao, Zhongxing; Gomez, Daniel; Cox, James [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Dong, Lei [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Welsh, James, E-mail: jwelsh@mdanderson.org [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)

2012-03-01T23:59:59.000Z

370

Measurement of environmental radiation exposure rates from Vernita, Hanford Reach, and Richland area shores. Addendum 1  

SciTech Connect

Environmental radiation exposure rate measurements are taken on and around the Hanford Site for Pacific Northwest Laboratory`s Hanford Site Surface Environmental Surveillance Project. In 1992, environmental radiation exposure rate measurements were taken from shoreline and island areas ranging from Vernita, along the Hanford Reach, down to the Richland Pumphouse. Measurements were taken primarily at locations known or expected to have elevated exposure rates as determined by examination of aerial photographs depicting radiation exposure measurements. Results from the 1992 survey indicated radiation exposure rates taken from the Hanford Reach area were elevated in comparison to the measurements taken from the Vernita area with ranges of 8 to 28 {mu}R/hr and 4 to 11 {mu}R/hr, respectively. In January 1994, additional shoreline radiation exposure rate measurements were taken from the Vernita, Hanford Reach, and Richland areas to determine the relationship of radiation exposure rates along the Richland area shores when compared to Vernita and Hanford Reach area exposure rates (measurements along the Richland area were not collected during the 1992 survey). This report discusses the 1994 results and is an addendum to the report that discussed the 1992 survey. An analysis of variance indicated a significant location interaction at a p-value of 0.0014. To determine differences between paried locations a post-hoc comparison of location means was performed on log transformed data using the Scheff{acute e}`s F-test. This test indicated a significant difference between Hanford Reach and Richland area means with a mean difference of 0.075 /{mu}R/hr and a p-value of 0.0014. No significant difference was found between Hanford Reach and Vernita area means: The mean difference was 0.031 {mu}R/hr and the p-value was 0.3138. No significant difference was found between Vernita and Richland area means with a mean difference of 0.044 {mu}R/hr and a p-value of 0.1155.

Cooper, A.T.

1995-02-01T23:59:59.000Z

371

Patient-specific radiation dose and cancer risk estimation in CT: Part II. Application to patients  

SciTech Connect

Purpose: Current methods for estimating and reporting radiation dose from CT examinations are largely patient-generic; the body size and hence dose variation from patient to patient is not reflected. Furthermore, the current protocol designs rely on dose as a surrogate for the risk of cancer incidence, neglecting the strong dependence of risk on age and gender. The purpose of this study was to develop a method for estimating patient-specific radiation dose and cancer risk from CT examinations. Methods: The study included two patients (a 5-week-old female patient and a 12-year-old male patient), who underwent 64-slice CT examinations (LightSpeed VCT, GE Healthcare) of the chest, abdomen, and pelvis at our institution in 2006. For each patient, a nonuniform rational B-spine (NURBS) based full-body computer model was created based on the patient's clinical CT data. Large organs and structures inside the image volume were individually segmented and modeled. Other organs were created by transforming an existing adult male or female full-body computer model (developed from visible human data) to match the framework defined by the segmented organs, referencing the organ volume and anthropometry data in ICRP Publication 89. A Monte Carlo program previously developed and validated for dose simulation on the LightSpeed VCT scanner was used to estimate patient-specific organ dose, from which effective dose and risks of cancer incidence were derived. Patient-specific organ dose and effective dose were compared with patient-generic CT dose quantities in current clinical use: the volume-weighted CT dose index (CTDI{sub vol}) and the effective dose derived from the dose-length product (DLP). Results: The effective dose for the CT examination of the newborn patient (5.7 mSv) was higher but comparable to that for the CT examination of the teenager patient (4.9 mSv) due to the size-based clinical CT protocols at our institution, which employ lower scan techniques for smaller patients. However, the overall risk of cancer incidence attributable to the CT examination was much higher for the newborn (2.4 in 1000) than for the teenager (0.7 in 1000). For the two pediatric-aged patients in our study, CTDI{sub vol} underestimated dose to large organs in the scan coverage by 30%-48%. The effective dose derived from DLP using published conversion coefficients differed from that calculated using patient-specific organ dose values by -57% to 13%, when the tissue weighting factors of ICRP 60 were used, and by -63% to 28%, when the tissue weighting factors of ICRP 103 were used. Conclusions: It is possible to estimate patient-specific radiation dose and cancer risk from CT examinations by combining a validated Monte Carlo program with patient-specific anatomical models that are derived from the patients' clinical CT data and supplemented by transformed models of reference adults. With the construction of a large library of patient-specific computer models encompassing patients of all ages and weight percentiles, dose and risk can be estimated for any patient prior to or after a CT examination. Such information may aid in decisions for image utilization and can further guide the design and optimization of CT technologies and scan protocols.

Li Xiang; Samei, Ehsan; Segars, W. Paul; Sturgeon, Gregory M.; Colsher, James G.; Toncheva, Greta; Yoshizumi, Terry T.; Frush, Donald P. [Medical Physics Graduate Program, Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Medical Physics Graduate Program, Department of Physics, and Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 and Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Duke Radiation Dosimetry Laboratory, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Duke Radiation Dosimetry Laboratory, Department of Radiology, Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 (United States); Division of Pediatric Radiology, Department of Radiology, Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27710 (United States)

2011-01-15T23:59:59.000Z

372

Virtual monochromatic imaging in dual-source dual-energy CT: Radiation dose and image quality  

Science Conference Proceedings (OSTI)

Purpose: To evaluate the image quality of virtual monochromatic images synthesized from dual-source dual-energy computed tomography (CT) in comparison with conventional polychromatic single-energy CT for the same radiation dose. Methods: In dual-energy CT, besides the material-specific information, one may also synthesize monochromatic images at different energies, which can be used for routine diagnosis similar to conventional polychromatic single-energy images. In this work, the authors assessed whether virtual monochromatic images generated from dual-source CT scanners had an image quality similar to that of polychromatic single-energy images for the same radiation dose. First, the authors provided a theoretical analysis of the optimal monochromatic energy for either the minimum noise level or the highest iodine contrast to noise ratio (CNR) for a given patient size and dose partitioning between the low- and high-energy scans. Second, the authors performed an experimental study on a dual-source CT scanner to evaluate the noise and iodine CNR in monochromatic images. A thoracic phantom with three sizes of attenuating rings was used to represent four adult sizes. For each phantom size, three dose partitionings between the low-energy (80 kV) and the high-energy (140 kV) scans were used in the dual-energy scan. Monochromatic images at eight energies (40 to 110 keV) were generated for each scan. Phantoms were also scanned at each of the four polychromatic single energy (80, 100, 120, and 140 kV) with the same radiation dose. Results: The optimal virtual monochromatic energy depends on several factors: phantom size, partitioning of the radiation dose between low- and high-energy scans, and the image quality metrics to be optimized. With the increase of phantom size, the optimal monochromatic energy increased. With the increased percentage of radiation dose on the low energy scan, the optimal monochromatic energy decreased. When maximizing the iodine CNR in monochromatic images, the optimal energy was lower than that when minimizing noise level. When the total radiation dose was equally distributed between low and high energy in dual-energy scans, for minimum noise, the optimal energies were 68, 71, 74, and 77 keV for small, medium, large, and extra-large (xlarge) phantoms, respectively; for maximum iodine CNR, the optimal energies were 66, 68, 70, 72 keV. With the optimal monochromatic energy, the noise level was similar to and the CNR was better than that in a single-energy scan at 120 kV for the same radiation dose. Compared to an 80 kV scan, however, the iodine CNR in monochromatic images was lower for the small, medium, and large phantoms. Conclusions: In dual-source dual-energy CT, optimal virtual monochromatic energy depends on patient size, dose partitioning, and the image quality metric optimized. With the optimal monochromatic energy, the noise level was similar to and the iodine CNR was better than that in 120 kV images for the same radiation dose. Compared to single-energy 80 kV images, the iodine CNR in virtual monochromatic images was lower for small to large phantom sizes.

Yu Lifeng; Christner, Jodie A.; Leng Shuai; Wang Jia; Fletcher, Joel G.; McCollough, Cynthia H. [Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905 (United States)

2011-12-15T23:59:59.000Z

373

Low dose radiation interations with the transformation growth factor (TGF)-beta pathway  

E-Print Network (OSTI)

A major limiting factor for long-term, deep-space missions is the radiation dose to astronauts. Because the dose to the astronauts is a mixed field of low- and high-LET radiation, there is a need to understand the effects of both radiation types on whole tissue; however, there are limited published data on the effects of high-LET (linearenergy- transfer) radiation on tissue. Thus, we designed a perfusion chamber system for rat trachea in order to mimic in vivo respiratory tissue. We successfully maintained the perfused tracheal tissue ex vivo in a healthy and viable condition for up to three days. In addition, this project studied the effects of high-LET Fe particles on the overall transformation growth factor (TGF)-beta response after TGF-beta inactivation and compared the results to the TGF-beta response post x-ray irradiation. It was found that a TGF-beta response could be measured in the perfused tracheal tissue, for x-ray and Fe particle irradiations, despite the high autofluorescent background intrinsic to tissue. However, after comparing the TGF-beta response of x-ray irradiation to High-Z-Highenergy (HZE) irradiation, there was not a significant difference in radiation types. The TGF-beta response in x-ray and HZE irradiated perfusion chambers was also measured over time post irradiation. It was found that for 6 hour and 8 hour post irradiation, the TGF-beta response was higher for lower doses of radiation than for higher doses. This is in contrast to the 0 hour fixation which found the TGF-beta response to increase with increased dose. The inverse relationship found for 6 hour and 8 hour fixation times may indicate a threshold response for TGF-beta response; i.e., for low doses, a threshold of dose must be reached for an immediate TGF-beta response, otherwise the tissue responds more slowly to the irradiation damage. This result was unexpected and will require further investigation to determine if the threshold can be determined for the 250 kVp x-rays and 1 Gev Fe particles.

Maslowski, Amy Jesse

2007-08-01T23:59:59.000Z

374

Assessment of the Effective Dose Equivalent for External Photon Radiation: Volume 2: Calculational Techniques for Estimating Externa l Effective Dose Equivalent from Dosimeter Readings  

Science Conference Proceedings (OSTI)

Recent revisions to the radiation protection standards contained in Title 10 Part 20 of the Code of Federal Regulations require nuclear power plants to assess a worker's "effective dose equivalent" (EDE). This report explains the concept of effective dose equivalent and describes research to improve the dosimetric methods presently used for assessing EDE.

1995-09-28T23:59:59.000Z

375

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

of Atomic Bomb Radiation Effects Life Span Study Report 8.reports derive mainly from the epidemiological studies of the Japanese atomic bomb

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

376

RESRAD-RECYCLE : a computer model for analyzing radiation exposures resulting from recycling radioactively contaminated scrap metals or reusing ratioactively surface-contaminated materials and equipment.  

Science Conference Proceedings (OSTI)

RESRAD-RECYCLE is a computer code designed by Argonne National Laboratory (ANL) to be used in making decisions about the disposition of radioactively contaminated materials and scrap metals. It implements a pathway analysis methodology to evaluate potential radiation exposures resulting from the recycling of contaminated scrap metals and the reuse of surface-contaminated materials and equipment. For modeling purposes, it divides the entire metal recycling process into six steps: (1) scrap delivery, (2) scrap melting, (3) ingot delivery, (4) product fabrication, (5) product distribution, and (6) use of finished product. RESRAD-RECYCLE considers the reuse of surface-contaminated materials in their original forms. It contains representative exposure scenarios for each recycling step and the reuse process; users can also specify scenarios if desired. The model calculates individual and collective population doses for workers involved in the recycling process and for the public using the finished products. The results are then used to derive clearance levels for the contaminated materials on the basis of input dose restrictions. The model accounts for radiological decay and ingrowth, dilution and partitioning during melting, and distribution of refined metal in the various finished products, as well as the varying densities and geometries of the radiation sources during the recycling process. A complete material balance in terms of mass and radioactivity during the recycling process can also be implemented. In an international validation study, the radiation doses calculated by RESRAD-RECYCLE were shown to agree fairly well with actual measurement data.

Cheng, J. J.; Kassas, B.; Yu, C.; Arnish, J. J.; LePoire, D.; Chen, S.-Y.; Williams, W. A.; Wallo, A.; Peterson, H.; Environmental Assessment; DOE; Univ. of Texas

2004-11-01T23:59:59.000Z

377

QUANTITY OF RADIATION REACHING GONADAL AREAS DURING THERAPY. IV. FACTORS INFLUENCING OVARY DOSE  

SciTech Connect

Attempts were made to evaluate the circumstances influencing the quantity of radiation reaching the ovaries during dermatologic radiation therapy, and to devise effective methods for reducing the amount to well within acceptable limits. Measurements were made in a specially constructed, life-size, pressed- wood (masonite) phantom which could be used in almost any position that might be assumed by man during routine x-ray therapy, and with provisions for insertion of an ionization chamber at the anatomic site representing an ovary. The various parameters which might influence ovary dose during conventional dermatologic x- ray procedures that were studied included: x-ray quality (kvp), tube current (ma), beam collimation and field size, shielding, angle of the beam in relation to the ovaries, and proximity of treatment site to the ovaries. Ovarian dose was measured during irradiation of the face, upper chest, and back, using each of the parameters alone and then in various combinations. The results, presented in tables and graphs, show that in order to minimize ovary dose during dermatologic x-ray therapy, one should utilize lower tube kilovoltage, softer radiation, appropriate collimation, effective shielding (minimizing area of field irraiated) with no added filtration, increased distance between the x-ray beam axis and the ovaries, and angling on the x-ray tube away from the ovaries. The gonad dose can best be reduced by exerting all of these simple and inexpensive means every time dermatologic radiation is administered. However, from these measurements it was evident that of the body areas studied, some may be irradiated without fear of exceeding even the max permissible dose to the ovaries, whereas other areas cannot be treated with x-rays without overdosing the ovaries regardless of the pre cautions taken. (BBB)

Witten, V.H.; Lee, H.

1963-05-01T23:59:59.000Z

378

Estimation of radiation doses for atomic-bomb survivors in the Hiroshima University Registry  

Science Conference Proceedings (OSTI)

The present study presents the Hiroshima University Registry of atomic bomb survivors, of which the total number is about 270,000, and application of absorbed doses. From this registry, we picked up 49,102 survivors and applied organ doses based on the dosimetry system 1986 (DS86), which is named the Atomic Bomb Survivor 1993 Dose (ABS93D). The applied dose data are based on the tables listed in the DS86 final report such as the free-in-air kermas, the house shielding factors, and organ dose factors for the active bone marrow and the breast. Calculations for the 13 other organs provided in DS86 are possible. To obtained the organ doses for each survivor, it is necessary to obtain information concerning (1) place exposed, (2) whether they were shielded or not, and (3) age. ABS93D body transmission factors for active bone marrow for neutrons and gamma rays agreed with DS 86 to within a few percent. Of the survivors studied, 35, 123 of them were used for the relative risk estimation of leukemia mortality, adopting the same method as the Radiation Effects Research Foundation (RERF) for comparison. For the observation period from 1968 to 1989, the analyzed relative risks for leukemia mortality at 1 Gy by shielded kerm and by active bone marrow dose are 2.01 and 2.37, respectively, which are consistent with the RERF results. 11 refs., 1 fig., 3 tabs.

Hoshi, M.; Matsuura, M.; Hayakawa, N.; Kamada, N. [Hiroshima Univ., Kasumi (Japan); Ito, C. [Hiroshima A-bomb Casualty Council Health Management Promotion Center, Senda-machi Naka-ku (Japan)

1996-05-01T23:59:59.000Z

379

Comparative Study of Different {beta}-Radiation Doses for Preventing Pterygium Recurrence  

SciTech Connect

Purpose: To compare the pterygium recurrence rates after treatment with two different {beta}-radiation doses. Methods and Materials: A total of 84 patients with a mean age of 63.0 {+-} 10.3 years (men, 48 eyes, and women, 47 eyes) and initially treated with {beta}-radiation after pterygium excision were recruited. The mean follow-up period was 49.9 {+-} 51.3 months. The patients were assigned to two dose groups: a high-dose (40 Gy) or a low-dose (20 Gy) group. The statistical significance of differences in patient age, pterygium size, and interval between surgery and radiotherapy were analyzed in the 20-Gy group using the Cox proportional hazard model at p < .05. Results: The high- and low-dose groups included 28 and 67 eyes, respectively. Pterygia recurred in 11 eyes, all in the low-dose group. The interval between surgery and radiotherapy was not a significant predictor of recurrence. Smaller pterygia had a lower risk of recurrence than pterygia that had encroached the pupillary area (pterygium located within one-third of the corneal radius from the limbus, corrected hazard ratio [HR], 0.069; 95% confidence interval [CI], 0.006-0.766; p = .030; pterygium extending beyond one-third of the corneal radius, corrected HR, 0.188; 95% CI, 0.018-0.696; p = 0.019; and pterygium reaching the pupillary area, corrected HR, 0.184; 95% CI, 0.036-0.929; p = .040). Older age was marginally significant as a negative predictor of recurrence (HR, 0.943; 95% CI, 0.887-1.003; p = .061). No scleromalacia developed during the follow-up period. Conclusions: {beta}-Radiation at 40 Gy was more efficacious than at 20 Gy in preventing pterygium recurrence without scleromalacia development, particularly for large-size pterygia and those in young patients.

Yamada, Takayuki, E-mail: tyamada-oph@umin.ac.jp [Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Mochizuki, Hideki [Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Ue, Takahiro [Department of Ophthalmology, Hiroshima Red Cross and Atomic Bomb Survivors Hospital, Hiroshima (Japan); Kiuchi, Yoshiaki [Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Takahashi, Yasuhiro [Department of Ophthalmology and Visual Science, Aichi Medical University School of Medicine, Aichi (Japan); Oinaka, Matsuyoshi [Department of Ophthalmology, Hiroshima Red Cross and Atomic Bomb Survivors Hospital, Hiroshima (Japan)

2011-12-01T23:59:59.000Z

380

MILDOS - A Computer Program for Calculating Environmental Radiation Doses from Uranium Recovery Operations  

Science Conference Proceedings (OSTI)

The MILDOS Computer Code estimates impacts from radioactive emissions from uranium milling facilities. These impacts are presented as dose commitments to individuals and the regional population within an 80 km radius of the facility. Only airborne releases of radioactive materials are considered: releases to surface water and to groundwater are not addressed in MILDOS. This code is multi-purposed and can be used to evaluate population doses for NEPA assessments, maximum individual doses for predictive 40 CFR 190 compliance evaluations, or maximum offsite air concentrations for predictive evaluations of 10 CFR 20 compliance. Emissions of radioactive materials from fixed point source locations and from area sources are modeled using a sector-averaged Gaussian plume dispersion model, which utilizes user-provided wind frequency data. Mechanisms such as deposition of particulates, resuspension. radioactive decay and ingrowth of daughter radionuclides are included in the transport model. Annual average air concentrations are computed, from which subsequent impacts to humans through various pathways are computed. Ground surface concentrations are estimated from deposition buildup and ingrowth of radioactive daughters. The surface concentrations are modified by radioactive decay, weathering and other environmental processes. The MILDOS Computer Code allows the user to vary the emission sources as a step function of time by adjustinq the emission rates. which includes shutting them off completely. Thus the results of a computer run can be made to reflect changing processes throughout the facility's operational lifetime. The pathways considered for individual dose commitments and for population impacts are: Inhalation External exposure from ground concentrations External exposure from cloud immersion Ingestioo of vegetables Ingestion of meat Ingestion of milk Dose commitments are calculated using dose conversion factors, which are ultimately based on recommendations of the International Commission on Radiological Protection (ICRP). These factors are fixed internally in the code, and are not part of the input option. Dose commitments which are available from the code are as follows: Individual dose commitments for use in predictive 40 CFR 190 compliance evaluations (Radon and short-lived daughters are excluded) Total individual dose commitments (impacts from all available radionuclides are considered) Annual population dose commitments (regional, extraregional, total and cummulative). This model is primarily designed for uranium mill facilities, and should not be used for operations with different radionuclides or processes.

Strange, D. L.; Bander, T. J.

1981-04-01T23:59:59.000Z

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381

Monte Carlo Simulations Of The Dose Distributions From Carbon Microbeams Used In An Experimental Radiation Therapy Method  

SciTech Connect

Recent upgrades of the MCNPX Monte Carlo code include transport of heavy ions. We employed the new code to simulate the energy and dose distributions produced by carbon beams in rabbit's head in and around a brain tumor. The work was within our experimental technique of interlaced carbon microbeams, which uses two 90 deg. arrays of parallel, thin planes of carbon beams (microbeams) interlacing to produce a solid beam at the target. A similar version of the method was earlier developed with synchrotron-generated x-ray microbeams. We first simulated the Bragg peak in high density polyethylene and other materials, where we could compare the calculated carbon energy deposition to the measured data produced at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL). The results showed that new MCNPX code gives a reasonable account of the carbon beam's dose up to {approx}200 MeV/nucleon beam energy. At higher energies, which were not relevant to our project, the model failed to reproduce the Bragg-peak's extent of increasing nuclear breakup tail. In our model calculations we determined the dose distribution along the beam path, including the angular straggling of the microbeams, and used the data for determining the optimal values of beam spacing in the array for producing adequate beam interlacing at the target. We also determined, for the purpose of Bragg-peak spreading at the target, the relative beam intensities of the consecutive exposures with stepwise lower beam energies, and simulated the resulting dose distribution in the spread out Bragg-peak. The details of the simulation methods used and the results obtained are presented.

Dioszegi, I. [Nonproliferation and National Security Department, Brookhaven National Laboratory, Upton, New York 11973 (United States); Rusek, A.; Chiang, I. H. [NASA Space Radiation Laboratory, Brookhaven National Laboratory, Upton, NY 11973 (United States); Dane, B. R. [Medical School, State University of New York at Stony Brook, Stony Brook, NY 11794 (United States); Meek, A. G. [Department of Radiation Oncology, State University of New York at Stony Brook, Stony Brook, NY 11794 (United States); Dilmanian, F. A. [Department of Radiation Oncology, State University of New York at Stony Brook, Stony Brook, NY 11794 (United States); Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States)

2011-06-01T23:59:59.000Z

382

Induction of potent local cellular immunity with low dose X4 SHIV{sub SF33A} vaginal exposure  

SciTech Connect

Intravaginal inoculation of rhesus macaques with varying doses of the CXCR4 (X4)-tropic SHIV{sub SF33A} isolate revealed a threshold inoculum for establishment of systemic virus infection and a dose dependency in overall viral burden and CD4+ T cell depletion. While exposure to inoculum size of 1000 or greater 50% tissue infectious dose (TCID{sub 50}) resulted in high viremia and precipitous CD4+ T cell loss, occult infection was observed in seven of eight macaques exposed to 500 TCID{sub 50} of the same virus. The latter was characterized by intermittent detection of low level virus with no evidence of seroconversion or CD4+ T cell decline, but with signs of an ongoing antiviral T cell immune response. Upon vaginal re-challenge with the same limiting dose 11-12 weeks after the first, classic pathogenic X4 SHIV{sub SF33A} infection was established in four of the seven previously exposed seronegative macaques, implying enhanced susceptibility to systemic infection with prior exposure. Pre-existing peripheral SIV gag-specific CD4+ T cells were more readily demonstrable in macaques that became systemically infected following re-exposure than those that were not. In contrast, early presence of circulating polyfunctional cytokine secreting CD8+ T cells or strong virus-specific proliferative responses in draining lymph nodes and in the gut associated lymphoid tissue (GALT) following the first exposure was associated with protection from systemic re-infection. These studies identify the gut and lymphoid tissues proximal to the genital tract as sites of robust CD8 T lymphocyte responses that contribute to containment of virus spread following vaginal transmission.

Tasca, Silvana; Tsai, Lily; Trunova, Nataliya; Gettie, Agegnehu [Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Ave., 7th Floor, New York, NY 10016 (United States); Saifuddin, Mohammed [CONRAD, Eastern Virginia Medical School, 1611 North Kent Street Suite 806, Arlington, VA 22209 (United States); Bohm, Rudolf [Tulane National Primate Research Center, Tulane University Medical Center, 18702 Three Rivers Road, Covington, LA 70433 (United States); Chakrabarti, Lisa [Institut Pasteur, Unite d'Immunologie Virale, 28 rue du Dr roux, 75724 Paris Cedex 15 (France); Cheng-Mayer, Cecilia [Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Ave., 7th Floor, New York, NY 10016 (United States)], E-mail: cmayer@adarc.org

2007-10-10T23:59:59.000Z

383

Nuclear Decay Data in the MIRD (Medical Internal Radiation Dose) Format  

DOE Data Explorer (OSTI)

MIRD is a database of evaluated nuclear decay data for over 2,100 radioactive nuclei. Data are extracted from ENSDF, processed by the program RadList, and used for medical internal radiation dose calculations. When using the MIRD interface, tables of nuclear and atomic radiations from nuclear decay and decay scheme drawings will be produced in the MIRD format from the Evaluated Nuclear Structure Data File (ENSDF) for the specified nuclide. Output may be either HTML-formatted tables and JPEG drawings, PostScript tables and drawings, or PDF tables and drawings.

384

On the Use of SRIM/TRIM for Computing Radiation Damage Exposure  

SciTech Connect

The SRIM (formerly TRIM) Monte Carlo simulation code is widely used to compute a number of parameters relevant to ion beam implantation and ion beam processing of materials. It also has the capability to compute a common radiation damage exposure unit known as atomic displacements per atom (dpa). Since dpa is a standard measure of primary radiation damage production, most researchers who employ ion beams as a tool for inducing radiation damage in materials use SRIM to determine the dpa associated with their irradiations. The use of SRIM for this purpose has been evaluated and comparisons with an internationally-recognized standard definition of dpa, as well as more detailed atomistic simulations of atomic displacement cascades have been made. Differences between the standard and SRIM-based dpa are discussed and recommendations for future usage of SRIM in radiation damage studies are made.

Stoller, Roger E [ORNL; Toloczko, M [Pacific Northwest National Laboratory (PNNL); Was, Gary [University of Michigan; Certain, Alicia [Pacific Northwest National Laboratory (PNNL); Dwaraknath, Shyam [University of Michigan

2013-01-01T23:59:59.000Z

385

TABLES OF RADIATION ABSORBED DOSE TO THE EMBRYO/FETUS FROM RADIOPHARMACEUTICALS  

NLE Websites -- All DOE Office Websites (Extended Search)

TABLES OF RADIATION ABSORBED DOSE TO THE EMBRYO/FETUS TABLES OF RADIATION ABSORBED DOSE TO THE EMBRYO/FETUS FROM RADIOPHARMACEUTICALS LATEST REVISION DATE: 1/21/98 The material in this document is taken from the Master's thesis of Ms. Joy Russell (University of Tennessee, Master's Degree conferred August 1995). The data below, and the methods and assumptions used to derive them, are published in two documents in the Health Physics Journal (73(5):747-755, 1997 and 73(5):756-769, 1997) and also in the Proceedings of the Sixth International Radiopharmaceutical Dosimetry Symposium. Please contact the center with any questions or comments about the data. Richard E. Toohey, 423-576-3448 phone, 423-576-8673 fax, tooheyr@orau.gov e-mail Audrey T. Stelson, 423-576-3450 phone, 423-576-8673 fax, stelsona@orau.gov e-mail

386

Low Dose Radiation Stimulates Antioxidant Capacity in the Brain and Lessens  

NLE Websites -- All DOE Office Websites (Extended Search)

Stimulates Antioxidant Capacity in the Brain and Lessens Stimulates Antioxidant Capacity in the Brain and Lessens Behavioral Symptoms in a 6-OHDA-Induced Rat Model of Parkinson's Disease Mohan Doss Fox Chase Cancer Center Abstract Background: Progressive degeneration of dopaminergic neurons in the substantia nigra (SN) pars compacta results in motor deficits in Parkinson’s disease (PD) patients. Oxidative damage to the nigral dopaminergic neurons has been implicated in the pathogenesis of Parkinson’s disease. Our hypothesis is that low dose radiation induces the production of antioxidants in the brain, which could provide protection to the dopaminergic neurons, potentially leading to prevention or stabilization of PD. The purpose of the study is (1) to determine the effect of low dose radiation on the total antioxidant capacity in SN in

387

Low Dose Radiation Research Program: Regulation of NF-kB and MnSOD in Low  

NLE Websites -- All DOE Office Websites (Extended Search)

NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells Jian Jian Li School of Health Sciences, Purdue University West Lafayette, Indiana Why this Project? To determine if low dose ionizing radiation-induced adaptive responses in skin cells are mediated by activation of signaling networks. Project Goals To evaluate the signaling networks involving transcription factor NF-kB and the mitochondrial antioxidant protein MnSOD. To determine if NF-kB is activated by low dose radiation in vivo. To determine if NF-kB activation is critical in the pathways that produce adaptive responses. Experimental Approach Cells transfected with NF-kB luciferase responder genes will be used to define a dose-response relationship for activation of the NF-kB gene. NF-kB

388

Radiation Protection at Industrial Radiography in Germany Exposures and Unusual Events  

E-Print Network (OSTI)

Abstract. In the Federal Republic of Germany safety related events in the use and transportation of radioactive materials as well as in the operation of accelerators are registered. The analysis of these events reveals their causation and allows this conclusions on avoidable errors. In this paper, a special insight is given into events in the field of gamma radiography which is a technical application of ionising radiation for non destructive testing of materials. Conclusions from analysis are drawn. In addition, the occupational radiation exposure of workers is presented taking into account that industrial radiography is performed under particular working conditions with different risks. 1.

Renate Czarwinski; Uwe Husler; Gerhard Frasch; Bundesamt Fr; Strahlenschutz Fachbereich Strahlenschutz Und Gesundheit

2006-01-01T23:59:59.000Z

389

Low Dose Radiation Research Program: Modeling the Physics of Damage Cluster  

NLE Websites -- All DOE Office Websites (Extended Search)

Modeling the Physics of Damage Cluster Formation in a Cellular Environment Modeling the Physics of Damage Cluster Formation in a Cellular Environment Larry Toburen East Carolina University Why This Project Modern tools of radiobiology are leading to many new discoveries regarding how cells and tissues respond to radiation exposure. We can now irradiate single cells and observe responses in adjacent cells. We can also measure clusters of radiation damage produced in DNA. The primary tools available to describe the initial spatial pattern of damage formed by the absorption of ionizing radiation are based on (MC) Monte Carlo simulations of the structure of charged particle tracks. Although many MC codes exist and considerable progress is being made in the incorporation of detailed macromolecular target structures into these codes, much of the interaction

390

Dosimetric impact of Acuros XB deterministic radiation transport algorithm for heterogeneous dose calculation in lung cancer  

SciTech Connect

Purpose: The novel deterministic radiation transport algorithm, Acuros XB (AXB), has shown great potential for accurate heterogeneous dose calculation. However, the clinical impact between AXB and other currently used algorithms still needs to be elucidated for translation between these algorithms. The purpose of this study was to investigate the impact of AXB for heterogeneous dose calculation in lung cancer for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT). Methods: The thorax phantom from the Radiological Physics Center (RPC) was used for this study. IMRT and VMAT plans were created for the phantom in the Eclipse 11.0 treatment planning system. Each plan was delivered to the phantom three times using a Varian Clinac iX linear accelerator to ensure reproducibility. Thermoluminescent dosimeters (TLDs) and Gafchromic EBT2 film were placed inside the phantom to measure delivered doses. The measurements were compared with dose calculations from AXB 11.0.21 and the anisotropic analytical algorithm (AAA) 11.0.21. Two dose reporting modes of AXB, dose-to-medium in medium (D{sub m,m}) and dose-to-water in medium (D{sub w,m}), were studied. Point doses, dose profiles, and gamma analysis were used to quantify the agreement between measurements and calculations from both AXB and AAA. The computation times for AAA and AXB were also evaluated. Results: For the RPC lung phantom, AAA and AXB dose predictions were found in good agreement to TLD and film measurements for both IMRT and VMAT plans. TLD dose predictions were within 0.4%-4.4% to AXB doses (both D{sub m,m} and D{sub w,m}); and within 2.5%-6.4% to AAA doses, respectively. For the film comparisons, the gamma indexes ({+-}3%/3 mm criteria) were 94%, 97%, and 98% for AAA, AXB{sub Dm,m}, and AXB{sub Dw,m}, respectively. The differences between AXB and AAA in dose-volume histogram mean doses were within 2% in the planning target volume, lung, heart, and within 5% in the spinal cord. However, differences up to 8% between AXB and AAA were found at lung/soft tissue interface regions for individual IMRT fields. AAA was found to be 5-6 times faster than AXB for IMRT, while AXB was 4-5 times faster than AAA for VMAT plan. Conclusions: AXB is satisfactorily accurate for the dose calculation in lung cancer for both IMRT and VMAT plans. The differences between AXB and AAA are generally small except in heterogeneous interface regions. AXB D{sub w,m} and D{sub m,m} calculations are similar inside the soft tissue and lung regions. AXB can benefit lung VMAT plans by both improving accuracy and reducing computation time.

Han Tao; Followill, David; Repchak, Roman; Molineu, Andrea; Howell, Rebecca; Salehpour, Mohammad [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Mikell, Justin [Department of Radiation Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States); Mourtada, Firas [Department of Radiation Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Department of Radiation Oncology, Christiana Care Health System, Newark, Delaware 19713 (United States)

2013-05-15T23:59:59.000Z

391

Low Dose Radiation Research Program: Multi-cellular Crosstalk in Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

About this Project About this Project Multi-cellular Crosstalk in Radiation Damage Technical Abstracts 2006 Workshop: Low-LET Bystander Effects in Cells In Vitro Are Significantly Less Than Published For High-LET Radiation Blakely, E.A., Thompson, A.C., Chang, P., Schwarz, R.I., Bjornstad, K., Rosen, C., Wisnewski, C., and Mocherla, D. 2005 Workshop: X-ray Microbeam Bystander Studies with Human Mammary Epithelial Cells and Fibroblasts Blakely, E.A., Schwarz, R.I., Thompson, A.C., Bjornstad, K.A., Chang, P.Y., Rosen, C.J., Sudar, D., Romano, R., and Parvin, B. 2003 Workshop: 12.5 keV X-ray Microbeam Bystander Studies with Human Mammary Epithelial Cells and Fibroblasts Blakely, E.A., Schwarz, R.I., Thompson, A.C., Bjornstad, K.A., Chang, P.Y., Rosen, C.J., and Sudar, D. 2001 Workshop:

392

High-dose MVCT image guidance for stereotactic body radiation therapy  

Science Conference Proceedings (OSTI)

Purpose: Stereotactic body radiation therapy (SBRT) is a potent treatment for early stage primary and limited metastatic disease. Accurate tumor localization is essential to administer SBRT safely and effectively. Tomotherapy combines helical IMRT with onboard megavoltage CT (MVCT) imaging and is well suited for SBRT; however, MVCT results in reduced soft tissue contrast and increased image noise compared with kilovoltage CT. The goal of this work was to investigate the use of increased imaging doses on a clinical tomotherapy machine to improve image quality for SBRT image guidance. Methods: Two nonstandard, high-dose imaging modes were created on a tomotherapy machine by increasing the linear accelerator (LINAC) pulse rate from the nominal setting of 80 Hz, to 160 Hz and 300 Hz, respectively. Weighted CT dose indexes (wCTDIs) were measured for the standard, medium, and high-dose modes in a 30 cm solid water phantom using a calibrated A1SL ion chamber. Image quality was assessed from scans of a customized image quality phantom. Metrics evaluated include: contrast-to-noise ratios (CNRs), high-contrast spatial resolution, image uniformity, and percent image noise. In addition, two patients receiving SBRT were localized using high-dose MVCT scans. Raw detector data collected after each scan were used to reconstruct standard-dose images for comparison. Results: MVCT scans acquired using a pitch of 1.0 resulted in wCTDI values of 2.2, 4.7, and 8.5 cGy for the standard, medium, and high-dose modes respectively. CNR values for both low and high-contrast materials were found to increase with the square root of dose. Axial high-contrast spatial resolution was comparable for all imaging modes at 0.5 lp/mm. Image uniformity was improved and percent noise decreased as the imaging dose increased. Similar improvements in image quality were observed in patient images, with decreases in image noise being the most notable. Conclusions: High-dose imaging modes are made possible on a clinical tomotherapy machine by increasing the LINAC pulse rate. Increasing the imaging dose results in increased CNRs; making it easier to distinguish the boundaries of low contrast objects. The imaging dose levels observed in this work are considered acceptable at our institution for SBRT treatments delivered in 3-5 fractions.

Westerly, David C.; Schefter, Tracey E.; Kavanagh, Brian D.; Chao, Edward; Lucas, Dan; Flynn, Ryan T.; Miften, Moyed [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States); Accuray Inc., Madison, Wisconsin 53717 (United States); Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 (United States); Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States)

2012-08-15T23:59:59.000Z

393

Comparison of radon fluxes with gamma-radiation exposure rates and soil /sup 226/Ra concentrations  

Science Conference Proceedings (OSTI)

Radon fluxes and contact gamma-radiation-exposure rates were measured at the grid points of rectangular grids on three properties in Edgemont, South Dakota that were known to have deposits of residual radioactivity relatively near to the surface. The coefficient of determination, r/sup 2/, between the radon fluxes and the contact gamma-radiation-exposure rates varied from 0.89 to 0.31 for the three properties. The property having the highest fluxes and residual radioactivity of relatively uniform depth showed the highest correlation between fluxes and exposure rates, and the property having residual radioactivity that varied considerably in depth showed the lowest. Correlations between fluxes and /sup 226/Ra concentrations measured in boreholes that varied in depth from 60 to 195 cm were lower than those between fluxes and exposure rates, indicating that exposure rates are better than /sup 226/Ra measurements for detecting elevated radon fluxes from near-surface deposits. Measurements made on one property at two different times indicated that if the average flux were determined from a large number (40) of measurements at one time, the average flux at a later time could be estimated from a few measurements using the assumption that the change in the flux at individual locations will be equal to the change in the average flux. Flux measurements around two buildings showing elevated indoor radon-daughter concentrations, but around which no residual radioactivity had been discovered by /sup 226/Ra and gamma-radiation measurements, provided no clear indication of the presence of such material, possibly because none was present.

Young, J.A.; Thomas, V.W.

1984-04-01T23:59:59.000Z

394

Radiation dose assessment methodology and preliminary dose estimates to support US Department of Energy radiation control criteria for regulated treatment and disposal of hazardous wastes and materials  

Science Conference Proceedings (OSTI)

This report provides unit dose to concentration levels that may be used to develop control criteria for radionuclide activity in hazardous waste; if implemented, these criteria would be developed to provide an adequate level of public and worker health protection, for wastes regulated under U.S, Environmental Protection Agency (EPA) requirements (as derived from the Resource Conservation and Recovery Act [RCRA] and/or the Toxic Substances Control Act [TSCA]). Thus, DOE and the US Nuclear Regulatory Commission can fulfill their obligation to protect the public from radiation by ensuring that such wastes are appropriately managed, while simultaneously reducing the current level of dual regulation. In terms of health protection, dual regulation of very small quantities of radionuclides provides no benefit.

Aaberg, R.L.; Baker, D.A.; Rhoads, K.; Jarvis, M.F.; Kennedy, W.E. Jr.

1995-07-01T23:59:59.000Z

395

Cellular and molecular level responses after radiofrequency radiation exposure, alone or in combination with x-rays or chemicals. Final report, 1 April 1991-30 September 1994  

SciTech Connect

This project was initiated to explore the potential bioeffects of microwave radiation, alone or in combination with ionizing radiation and chemicals. Over the time period of the project, an automated thermal control system, to be used for maintaining the temperature in tissue culture medium during microwave exposures, was designed, constructed, and software was created. While this was underway during the project period, numerous positive control biological experiments were performed on two different cell types, the Epstein Barr Virus transformed 244B human lymphoblastoid cell, and the freshly isolated peripheral human lymphocyte. The 244B cells were used to address the question of whether a physical agent, ionizing radiation, at low doses where cells would predominantly remain viable, would induce the DNA binding protein NF-kB, and/or four immediate early genes (IEG) (protooncogenes).

Meltz, M.L.; Natarajan, M.; Prasad, A.V.

1995-02-21T23:59:59.000Z

396

NIST Ionizing Radiat. Div. - 2004: Strategic Focus 1  

Science Conference Proceedings (OSTI)

... and to determine exposure or dose-rate values ... to maximize the energy absorption of the ionizing radiation. ... the calibration of an 55 Fe low-energy x ...

397

Technology Assessment and Roadmap for the Emergency Radiation Dose Assessment Program  

SciTech Connect

A Joint Interagency Working Group (JIWG) under the auspices of the Department of Homeland Security Office of Research and Development conducted a technology assessment of emergency radiological dose assessment capabilities as part of the overall need for rapid emergency medical response in the event of a radiological terrorist event in the United States. The goal of the evaluation is to identify gaps and recommend general research and development needs to better prepare the Country for mitigating the effects of such an event. Given the capabilities and roles for responding to a radiological event extend across many agencies, a consensus of gaps and suggested development plans was a major goal of this evaluation and road-mapping effort. The working group consisted of experts representing the Departments of Homeland Security, Health and Human Services (Centers for Disease Control and the National Institutes of Health), Food and Drug Administration, Department of Defense and the Department of Energy's National Laboratories (see appendix A for participants). The specific goals of this Technology Assessment and Roadmap were to: (1) Describe the general context for deployment of emergency radiation dose assessment tools following terrorist use of a radiological or nuclear device; (2) Assess current and emerging dose assessment technologies; and (3) Put forward a consensus high-level technology roadmap for interagency research and development in this area. This report provides a summary of the consensus of needs, gaps and recommendations for a research program in the area of radiation dosimetry for early response, followed by a summary of the technologies available and on the near-term horizon. We then present a roadmap for a research program to bring present and emerging near-term technologies to bear on the gaps in radiation dose assessment and triage. Finally we present detailed supporting discussion on the nature of the threats we considered, the status of technology today, promising emerging technologies and references for further reading.

Turteltaub, K W; Hartman-Siantar, C; Easterly, C; Blakely, W

2005-10-03T23:59:59.000Z

398

DOE 2011 Occupational Radiation Exposure report, _Prepared for the U.S. Department of Energy, Office of Health, Safety and Security. December 2012  

Science Conference Proceedings (OSTI)

This report discusses radiation protection and dose reporting requirements, presents the 2011 occupational radiation dose data along with trends over the past 5 years, and provides instructions to submit successful as low as reasonably achievable (ALARA) projects.

Derek Hagemeyer, Yolanda McCormick

2012-12-12T23:59:59.000Z

399

Systematic measurements of whole-body dose distributions for various treatment machines and delivery techniques in radiation therapy  

Science Conference Proceedings (OSTI)

Purpose: Contemporary radiotherapy treatment techniques, such as intensity-modulated radiation therapy and volumetric modulated arc therapy, could increase the radiation-induced malignancies because of the increased beam-on time, i.e., number of monitor units needed to deliver the same dose to the target and the larger volume irradiated with low doses. In this study, whole-body dose distributions from typical radiotherapy patient plans using different treatment techniques and therapy machines were measured using the same measurement setup and irradiation intention. Methods: Individually calibrated thermoluminescent dosimeters were used to measure absorbed dose in an anthropomorphic phantom at 184 locations. The dose distributions from 6 MV beams were compared in terms of treatment technique (3D-conformal, intensity-modulated radiation therapy, volumetric modulated arc therapy, helical TomoTherapy, stereotactic radiotherapy, hard wedges, and flattening filter-free radiotherapy) and therapy machine (Elekta, Siemens and Varian linear accelerators, Accuray CyberKnife and TomoTherapy). Results: Close to the target, the doses from intensity-modulated treatments (including flattening filter-free) were below the dose from a static treatment plan, whereas the CyberKnife showed a larger dose by a factor of two. Far away from the treatment field, the dose from intensity-modulated treatments showed an increase in dose from stray radiation of about 50% compared to the 3D-conformal treatment. For the flattening filter-free photon beams, the dose from stray radiation far away from the target was slightly lower than the dose from a static treatment. The CyberKnife irradiation and the treatment using hard wedges increased the dose from stray radiation by nearly a factor of three compared to the 3D-conformal treatment. Conclusions: This study showed that the dose outside of the treated volume is influenced by several sources. Therefore, when comparing different treatment techniques, the dose ratios vary with distance to the isocenter. The effective dose outside the treated volume of intensity-modulated treatments with or without flattening filter was 10%-30% larger when compared to 3D-conformal radiotherapy. This dose increase is much lower than the monitor unit scaled effective dose from a static treatment.

Haelg, Roger A.; Besserer, Juergen; Schneider, Uwe [Institute for Radiotherapy, Radiotherapie Hirslanden AG, Aarau 5000 (Switzerland); Vetsuisse Faculty, University of Zurich, Zurich 8057 (Switzerland) and Institute for Radiotherapy, Radiotherapie Hirslanden AG, Aarau 5000 (Switzerland)

2012-12-15T23:59:59.000Z

400

Assessing risks from occupational exposure to low-level radiation: The statistician's role  

SciTech Connect

Currently, several epidemiological studies of workers who have been exposed occupationally to radiation are being conducted. These include workers in the United States, Great Britain, and Canada, involved in the production of both defense materials and nuclear power. A major reason for conducting these studies is to evaluate possible adverse health effects that may have resulted because of the radiation exposure received. The general subject of health effects resulting from low levels of radiation, including these worker studies, has attracted the attention of various news media, and has been the subject of considerable controversy. These studies provide a good illustration of certain other aspects of the statistician's role; namely, communication and adequate subject matter knowledge. A competent technical job is not sufficient if these other aspects are not fulfilled.

Gilbert, E.S.

1989-06-01T23:59:59.000Z

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401

Worker radiation doses in the United States at the dawn of the atomic era (1940--1960)  

SciTech Connect

Radiation doses to workers at the Manhattan Engineer District (MED) and US Atomic Energy Commission (AEC) sites due to external irradiation during 1940--1960 are reviewed. Categorized radiation dose data were available from AEC annual reports for some years. Annual individual radiation dose data for ten MED/AEC sites for all years were available from the US Department of Energy`s (DOE) Comprehensive Epidemiologic Data Resource (CEDR). These data are combined to produce an estimate of external collective dose equivalent to 172,000 person-rems (1720 person-Sv) for 1940--1960. During this period there were 41 overexposures, 19 criticality incidents, and 3 deaths due to acute radiation syndrome among several hundred thousand workers.

Strom, D.J.; Smith, M.H.; Swinth, K.L. [Pacific Northwest Lab., Richland, WA (United States); Pettengill, H.J. [Westinghouse Hanford Co., Richland, WA (United States)

1994-06-01T23:59:59.000Z

402

Effects of radiation exposure on SRL 131 composition glass in a steam environment  

Science Conference Proceedings (OSTI)

Monoliths of SRL 131 borosilicate glass were irradiated in a saturated air-steam environment, at temperatures of 150{degree}C, to examine the effects of radiation on nuclear waste glass behavior. Half of the tests used actinide and Tc-99 doped glass and were exposed to an external ionizing gamma source, while the remaining glass samples were doped only with uranium and were reacted without any external radiation exposure. The effects of radiation exposure on glass alteration and secondary phase formation were determined by comparing the reaction rates and mineral paragenesis of the two sets of samples. All glass samples readily reacted with the water that condensed on their surfaces, producing a smectite clay layer within the first three days of testing. Additional crystalline phases precipitated on the altered glass surface with increasing reaction times, including zeolites, smectite, calcium and sodium silicates, phosphates, evaporitic salts, and uranyl silicates. Similar phases were produced on both the nonirradiated and irradiated samples; however, the quantity of precipitates was increased and the rate of paragenetic sequence development was accelerated in the latter. After 56 days of testing, the smectite layer developed at an average rate of {approximately}0.16 and 0.63 {mu}m/day for the nonirradiated and irradiated samples, respectively. These comparisons indicate that layer development is accelerated approximately four-fold due to the radiation exposure at high glass surface area/liquid volume (SA/V) conditions. This increase apparently occurs in response to the rapid concentration of radiolytic products, including nitric acid, in the thin films of water contacting the sample monoliths.

Wronkiewicz, D.J.; Bradley, C.R.; Bates, J.K. [Argonne National Lab., IL (United States); Wang, L.M. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Geology

1993-11-01T23:59:59.000Z

403

Chloroquine Improves Survival and Hematopoietic Recovery After Lethal Low-Dose-Rate Radiation  

SciTech Connect

Purpose: We have previously shown that the antimalarial agent chloroquine can abrogate the lethal cellular effects of low-dose-rate (LDR) radiation in vitro, most likely by activating the ataxia-telangiectasia mutated (ATM) protein. Here, we demonstrate that chloroquine treatment also protects against lethal doses of LDR radiation in vivo. Methods and Materials: C57BL/6 mice were irradiated with a total of 12.8 Gy delivered at 9.4 cGy/hour. ATM null mice from the same background were used to determine the influence of ATM. Chloroquine was administered by two intraperitoneal injections of 59.4 {mu}g per 17 g of body weight, 24 hours and 4 hours before irradiation. Bone marrow cells isolated from tibia, fibula, and vertebral bones were transplanted into lethally irradiated CD45 congenic recipient mice by retroorbital injection. Chimerism was assessed by flow cytometry. In vitro methylcellulose colony-forming assay of whole bone marrow cells and fluorescence activated cell sorting analysis of lineage depleted cells were used to assess the effect of chloroquine on progenitor cells. Results: Mice pretreated with chloroquine before radiation exhibited a significantly higher survival rate than did mice treated with radiation alone (80% vs. 31%, p = 0.0026). Chloroquine administration before radiation did not affect the survival of ATM null mice (p = 0.86). Chloroquine also had a significant effect on the early engraftment of bone marrow cells from the irradiated donor mice 6 weeks after transplantation (4.2% vs. 0.4%, p = 0.015). Conclusion: Chloroquine administration before radiation had a significant effect on the survival of normal but not ATM null mice, strongly suggesting that the in vivo effect, like the in vitro effect, is also ATM dependent. Chloroquine improved the early engraftment of bone marrow cells from LDR-irradiated mice, presumably by protecting the progenitor cells from radiation injury. Chloroquine thus could serve as a very useful drug for protection against the harmful effects of LDR radiation.

Lim Yiting [Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)] [Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Hedayati, Mohammad; Merchant, Akil A.; Zhang Yonggang; Yu, Hsiang-Hsuan M. [Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)] [Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Kastan, Michael B. [Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee (United States) [Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee (United States); Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina (United States); Matsui, William, E-mail: matsuwi@jhmi.edu [Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)] [Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); DeWeese, Theodore L., E-mail: deweete@jhmi.edu [Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)

2012-11-01T23:59:59.000Z

404

Radiation Therapy With Full-Dose Gemcitabine and Oxaliplatin for Unresectable Pancreatic Cancer  

Science Conference Proceedings (OSTI)

Purpose: We completed a Phase I trial of gemcitabine and oxaliplatin with concurrent radiotherapy in patients with previously untreated pancreatic cancer. The results of a subset of patients with unresectable disease who went on to receive planned additional therapy are reported here. Methods and Materials: All patients received two 28-day cycles of gemcitabine (1,000 mg/m{sup 2} on Days 1, 8, and 15) and oxaliplatin (40-85 mg/m{sup 2} on Days 1 and 15, per a dose-escalation schema). Radiation therapy was delivered concurrently with Cycle 1 (27 Gy in 1.8-Gy fractions). At 9 weeks, patients were reassessed for resectability. Those deemed to have unresectable disease were offered a second round of treatment consisting of 2 cycles of gemcitabine and oxaliplatin and 27 Gy of radiation therapy (total, 54 Gy). Radiation was delivered to the gross tumor volume plus 1 cm by use of a three-dimensional conformal technique. We used the Common Terminology Criteria for Adverse Events to assess acute toxicity. Late toxicity was scored per the Radiation Therapy Oncology Group scale. Computed tomography scans were reviewed to determine pattern of failure, local response, and disease progression. Kaplan-Meier methodology and Cox regression models were used to evaluate survival and freedom from failure. Results: Thirty-two patients from the Phase I dose-escalation study had unresectable disease, three of whom had low-volume metastatic disease. Of this group, 16 patients went on to receive additional therapy to complete a total of 4 cycles of chemotherapy and 54 Gy of concurrent radiation. For this subset, 38% had at least a partial tumor response at a median of 3.2 months. Median survival was 11.8 months (range, 4.4-26.3 months). The 1-year freedom from local progression rate was 93.8% (95% confidence interval, 63.2-99.1). Conclusions: Radiation therapy to 54 Gy with concurrent full-dose gemcitabine and oxaliplatin is well tolerated and results in favorable rates of local tumor response and 1-year freedom from local progression.

Hunter, Klaudia U.; Feng, Felix Y. [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States); Griffith, Kent A. [Comprehensive Cancer Center Biostatistics Unit, University of Michigan, Ann Arbor, MI (United States); Francis, Isaac R. [Department of Radiology, University of Michigan, Ann Arbor, MI (United States); Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States); Desai, Sameer [Department of Internal Medicine, University of Michigan, Ann Arbor, MI (United States); Murphy, James D. [School of Medicine, University of Michigan, Ann Arbor, MI (United States); Zalupski, Mark M. [Department of Internal Medicine, University of Michigan, Ann Arbor, MI (United States); Ben-Josef, Edgar, E-mail: edgarb@med.umich.edu [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)

2012-07-01T23:59:59.000Z

405

External Dose Estimates from  

E-Print Network (OSTI)

Appendix E External Dose Estimates from NTS Fallout E-1 #12;External Radiation Exposure as the dependence on fallout time of arrival. The most exposed individuals were outdoor workers; the least exposed was about a factor of 20 less than that from "global fallout" from high- yield weapons tests carried out

406

MOLECULAR MECHANISM OF SUPPRESSION OF NEOPLASTIC TRANSFORMATION BY LOW DOSES OF LOW LET RADIATION  

Science Conference Proceedings (OSTI)

We are currently funded (9/01-8/04) by the DOE Low Dose Radiation Research Program to examine mechanisms underlying the suppression of neoplastic transformation in vitro by low doses of low LET radiation. For the new studies proposed under Notice 04-21, we intend to follow up on our observation that upregulation of DNA repair may be an important factor and that its importance is dose-dependent. The experimental system will be the human hybrid cell neoplastic transformation assay that we are currently using. We propose to test the following hypothesis: Down-regulation of DNA dsb repair will abrogate the low dose suppression of neoplastic transformation. Using the technique of RNA silencing, it is proposed to test the effect of down-regulation of the two major DNA dsb repair pathways, homologous recombination (HR) and non-homologous end-joining (NHEJ), on the dose response relationship for neoplastic transformation. Based on prior studies, we predict that this will result in abrogation of the suppressive effect at doses in the range 1 to 10 cGy, but not at lower doses. The proposed experiments will also help address the question as to which of the two DNA repair pathways may be the most important in causing suppression of transformation. HR is a pathway that is predominant in S and G2 phase cells and is known to be less error-prone than the NHEJ pathway that is predominant in G1 phase. We hypothesize that down-regulation of HR will result in the most effective abrogation of suppression. An important component of this study will be the determination of the how abrogation of DNA dsb repair impacts the spontaneous transformation frequency, presumably a consequence of endogeneous DNA damage. Experiments will be carried out using partially synchronized populations of cells enriched for G1 and S/G2 respectively. In addition to the endpoint of neoplastic transformation the impact of down-regulation of HR and NHEJ on the formation and disappearance of the DNA dsb marker, gamma-H2AX, will be studied.

J.LESIE REDPATH, PH.D.

2011-03-29T23:59:59.000Z

407

Low Dose Radiation Induced DNA Damage Signaling and Repair Responses in  

NLE Websites -- All DOE Office Websites (Extended Search)

Induced DNA Damage Signaling and Repair Responses in Induced DNA Damage Signaling and Repair Responses in Human 3-Dimensional Skin Model System Yanrong Su, Jarah Meador and Adayabalam S. Balajee Center for Radiological Research, College of Physicians and Surgeons, Columbia University, 630 West, 168th Street, New York, NY 10032. Exposure to ionizing radiation (IR) inflicts a wide variety of lesions in the genomic DNA. Among them, DNA double strand break (DSB) is considered to be the critical lesion for most of the deleterious radiation effects including carcinogenesis. Much of our knowledge on induction and repair kinetics of DSB has come from studies in two dimensional cell culture systems. However, the damage signaling and repair responses to DSB in tissue microenvironment are largely unknown. Knowledge of tissue responses to

408

INDOS: conversational computer codes to implement ICRP-10-10A models for estimation of internal radiation dose to man  

SciTech Connect

INDOS1, INDOS2, and INDOS3 (the INDOS codes) are conversational FORTRAN IV programs, implemented for use in time-sharing mode on the ORNL PDP-10 System. These codes use ICRP10-10A models to estimate the radiation dose to an organ of the body of Reference Man resulting from the ingestion or inhalation of any one of various radionuclides. Two patterns of intake are simulated: intakes at discrete times and continuous intake at a constant rate. The IND0S codes provide tabular output of dose rate and dose vs time, graphical output of dose vs time, and punched-card output of organ burden and dose vs time. The models of internal dose calculation are discussed and instructions for the use of the INDOS codes are provided. The INDOS codes are available from the Radiation Shielding Information Center, Oak Ridge National Laboratory, P. O. Box X, Oak Ridge, Tennessee 37830. (auth)

Killough, G.G.; Rohwer, P.S.

1974-03-01T23:59:59.000Z

409

Review of exposure limits and experimental data for corneal and lenticular damage from short pulsed UV and IR laser radiation  

E-Print Network (OSTI)

for publication 30 October 2007; published 22 April 2008 Laser exposure limits as promulgated by the International at the international level by ICNIRP the International Commission on Non-Ionizing Radiation Protection.1,2 OtherReview of exposure limits and experimental data for corneal and lenticular damage from short pulsed

410

Low Dose Radiation Research Program: A Variable Energy Soft X-ray  

NLE Websites -- All DOE Office Websites (Extended Search)

Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation Induced Bystander Effect. Authors: Melvyn Folkard, Borivoj Vojnovic, Giuseppe Schettino, Kevin M Prise and Barry D Michael. Institutions: Gray Cancer Institute. We are currently engaged on two projects in the Low-dose Program: "Low dose studies with focused X-rays in cell and tissue models: mechanisms of bystander and genomic instability responses" (DE-FG07-99ER62877) and "Mechanistic modeling of bystander effects: An integrated theoretical and experimental approach" (DE-FG02-02ER63305). Central to both of these studies is a unique micro irradiation facility that uses ultrasoft X-rays focused to a sub micron beam for individual cell and sub cellular targeting. This facility allows us to selectively irradiate individual

411

Limitations and Problems in Deriving Risk Estimates for Low-level Radiation Exposure  

E-Print Network (OSTI)

Some of the problems in determining the cancer risk of low-level radiation from studies of exposed groups are reviewed and applied to the study of Hanford workers by Mancuso, Stewart, and Kneale. Problems considered are statistical limitations, variation of cancer rates with geography and race, the "healthy worker effect, " calendar year and age variation of cancer mortality, choosing from long lists, use of proportional mortality rates, cigarette smoking-cancer correlations, use of averages to represent data distributions, ignoring other data, and correlations between radiation exposure and other factors that may cause cancer. The current status of studies of the Hanford workers is reviewed. There have been several papers in recent years purporting to give evidence that low level radiation (- 10 rad) is more dangerous than indicated by conventional estimates like those of the National Academy of Sciences Committee on Biological Effects of Ionizing Radiation (BEIR) [1], the United Nations Scientific Committee on Effects of Atomic Radiation (UNSCEAR) [21, and the International Commission on Radiological Protection (ICRP) [3]. The best known of these is the study by Mancuso, Stewart, and Kneale [4] (hereafter referred to as MSK) on workers at the

Bernard L. Cohen; D. Sc

1981-01-01T23:59:59.000Z

412

Low Dose Radiation Research Program: A Variable-Energy Soft X-Ray  

NLE Websites -- All DOE Office Websites (Extended Search)

A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect. Authors: Melvyn Folkard, Borivoj Vojnovic, Giuseppe Schettino, Kirk Atkinson, Kevin M Prise, Barry D Michael Institutions: Gray Cancer Institute, PO BO Box100, Mount Vernon Hospital, Northwood, HA6 2JR, UK The Gray Cancer Institute (GCI) has pioneered the use of X-ray focussing techniques to develop systems for micro-irradiating individual cells and sub-cellular targets. Our prototype X-ray microprobe was developed alongside our existing charged-particle microbeam to address problems specific to low LET radiations, or where very precise targeting accuracy and dose delivery are required. This facility was optimised for focusing 278 eV CK X-rays; however there are a number of reasons for extending the

413

Low Dose Radiation Research Program: A Paracrine Signal Mediates The Cell  

NLE Websites -- All DOE Office Websites (Extended Search)

A Paracrine Signal Mediates The Cell Transformation Response To Low A Paracrine Signal Mediates The Cell Transformation Response To Low Dose Gamma Radiation in JB6 Cells. Authors: Thomas J. Weber,1 Robert W. Siegel,2 Lye M. Markillie,1 William B. Chrisler,1 Xingye C. Lei,3 and Nancy H. Colburn4 Institutions: 1Cell Biology and Biochemistry, Pacific Northwest National Laboratory, Richland, Washington. 2Protein Function, Pacific Northwest National Laboratory, Richland, Washington. 3Statistical and Mathematical Sciences, Pacific Northwest National Laboratory, Richland, Washington. 4Gene Regulation Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Frederick, Maryland. The carcinogenic response to radiation is complex and may involve adaptive cellular responses as well as a bystander effect mediated by paracrine or

414

Measuring Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Measurement Activity SI Units and Prefixes Conversions Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration...

415

Brachial Plexus-Associated Neuropathy After High-Dose Radiation Therapy for Head-and-Neck Cancer  

SciTech Connect

Purpose: To identify clinical and treatment-related predictors of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer. Methods and Materials: Three hundred thirty patients who had previously completed radiation therapy for head-and-neck cancer were prospectively screened using a standardized instrument for symptoms of neuropathy thought to be related to brachial plexus injury. All patients were disease-free at the time of screening. The median time from completion of radiation therapy was 56 months (range, 6-135 months). One-hundred fifty-five patients (47%) were treated by definitive radiation therapy, and 175 (53%) were treated postoperatively. Radiation doses ranged from 50 to 74 Gy (median, 66 Gy). Intensity-modulated radiation therapy was used in 62% of cases, and 133 patients (40%) received concurrent chemotherapy. Results: Forty patients (12%) reported neuropathic symptoms, with the most common being ipsilateral pain (50%), numbness/tingling (40%), motor weakness, and/or muscle atrophy (25%). When patients with <5 years of follow-up were excluded, the rate of positive symptoms increased to 22%. On univariate analysis, the following factors were significantly associated with brachial plexus symptoms: prior neck dissection (p = 0.01), concurrent chemotherapy (p = 0.01), and radiation maximum dose (p < 0.001). Cox regression analysis confirmed that both neck dissection (p < 0.001) and radiation maximum dose (p < 0.001) were independently predictive of symptoms. Conclusion: The incidence of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer may be underreported. In view of the dose-response relationship identified, limiting radiation dose to the brachial plexus should be considered when possible.

Chen, Allen M., E-mail: allen.chen@ucdmc.ucdavis.edu [Department of Radiation Oncology, University of California, Davis School of Medicine, Sacramento, California (United States); Hall, William H. [Department of Radiation Oncology, University of California, Davis School of Medicine, Sacramento, California (United States)] [Department of Radiation Oncology, University of California, Davis School of Medicine, Sacramento, California (United States); Li, Judy; Beckett, Laurel [Department of Biostatistics, University of California, Davis School of Medicine, Sacramento, California (United States)] [Department of Biostatistics, University of California, Davis School of Medicine, Sacramento, California (United States); Farwell, D. Gregory [Department of Otolaryngology-Head and Neck Surgery, University of California, Davis School of Medicine, Sacramento, California (United States)] [Department of Otolaryngology-Head and Neck Surgery, University of California, Davis School of Medicine, Sacramento, California (United States); Lau, Derick H. [Department of Medical Oncology, University of California, Davis School of Medicine, Sacramento, California (United States)] [Department of Medical Oncology, University of California, Davis School of Medicine, Sacramento, California (United States); Purdy, James A. [Department of Radiation Oncology, University of California, Davis School of Medicine, Sacramento, California (United States)] [Department of Radiation Oncology, University of California, Davis School of Medicine, Sacramento, California (United States)

2012-09-01T23:59:59.000Z

416

Effect of low-dose, low-LET γ-radiation and BaP injection on pulmonary  

NLE Websites -- All DOE Office Websites (Extended Search)

low-dose, low-LET γ-radiation and BaP injection on pulmonary low-dose, low-LET γ-radiation and BaP injection on pulmonary immunity in A/J mice K. Gott Lovelace Respiratory Research Institute Abstract Introduction: Low-dose, low-linear-energy-transfer (LET) radiation (LDR; < 100 mGy) activates the immune response (Nowosielska et al., 2006), presumably via epigenetic pathways (Scott et al., 2009) and has been implicated as suppressing both alpha-radiation-induced and smoking-related lung cancer (Scott et al. 2009). One of the hypothesized adaptive-response mechanisms by which LDR does so is by activating immune cell function in the lung, which would then increase their anti-cancer surveillance function (Liu, 2007; Bogdandi et al., 2010). One measure of activated immune cell function is their expression of markers on their cell surface that are

417

ORIGINAL ARTICLE Biodistribution and radiation dosimetry of a positron  

E-Print Network (OSTI)

. Radiation-absorbed doses were estimated by the Medical Internal Radiation Dose scheme. Results After injecting 18 F-SP203, the two organs with highest radiation exposure were urinary bladder wallORIGINAL ARTICLE Biodistribution and radiation dosimetry of a positron emission tomographic ligand

Shen, Jun

418

Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Low Dose Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Low Dose Radiation Francis A. Cucinotta 1 , Yongfeng Li 2 , Minli Wang 2 , Claudio Carra 2 , Janice Pluth 3 , and Peter O'Neill 4 1 NASA Johnson Space Center, Houston, TX 2 U.S.R.A. Division of Life Sciences, Houston TX 3 Lawrence Berkeley National Laboratory, Berkeley CA 4 Oxford University, Oxford UK Abstract: Modular systems biology (MSB) describes the complexity of biological systems using well defined modules that represent distinct biological response pathways or sub-systems within pathways. We review mathematical concepts from control theory that can be used to identify and construct well defined modules for describing complex biological processes. The DNA damage response and TGFbeta/Smad signaling are two important response pathways following

419

Relationship of five anthropometric measurements at age 18 to radiation dose among atomic bomb survivors exposed in utero  

SciTech Connect

Five body measurements-standing height, body weight, sitting height, chest circumference and intercristal diameter-of 18-year-old atomic bomb survivors exposed in utero in Hiroshima and Nagasaki were analyzed in relation to DS86 uterine dose. Age in utero was divided into four periods: 0-7, 8-15, 16-25 and [>=]26 weeks. This categorization is based upon the study of radiation-induced brain damage. The linear regression analyses for these five variables showed significant decreases with increasing dose. The regression coefficients were -2.65 cm/Gy for standing height, -2.46 kg/Gy for body weight, -0.92 cm/Gy for sitting height, -1.37 cm/Gy for chest circumference and -0.32 cm/Gy for intercristal diameter. The multivariate test statistic for the overall dose effect on five body measurements was significant, but the interaction between dose and gestational period was not significant. Principal-component analysis was applied to the five variables. For the first-component scores, the dose effect was significant, but the interaction between dose and gestational period was not significant. For the second-component scores, the dose effect was significant specifically at 0.7 weeks. The radiation dose effect on the second principal component found at 0-7 weeks of gestation suggests that malformation occur in this period. 17 refs., 2 figs., 4 tabs.

Nakashima, Eiji (Radiation Effects Research Foundation, Minami-ku (Japan))

1994-04-01T23:59:59.000Z

420

Use of international data sets to evaluate and validate pathway assessment models applicable to exposure and dose reconstruction at DOE facilities. Progress report, March--May 1994  

Science Conference Proceedings (OSTI)

The project described in this report was the result of a Memorandum of Cooperation between the US and the former-USSR following the accident at the Chernobyl Nuclear Power Plant Unit 4. A joint program was established to improve the safety of nuclear power plants and to understand the implications of environmental releases. The task of Working Group 7 was ``to develop jointly methods to project rapidly the health effects of any future nuclear reactor accident.`` The current objective of this project is to evaluate and validate pathway-assessment models applicable to exposure and dose reconstruction at DOE facilities through use of international data sets. This project incorporates data used for the prediction of radionuclide transfer through agricultural and aquatic systems to humans. It also includes participation in two multinational studies, BIOMOVS (Biospheric Model Validation Study) with the Swedish National Institute for Radiation Protection and VAMP (Validation of Model Predictions) with the International Atomic Energy Agency, that address testing the performance of models of radionuclide transport through foodchains. In the future, this project will be considered separately from the Chernobyl Studies Project and the essential activities of former Task 7.1D will be folded within the broader umbrella of the BIOMOVS and VAMP projects. The Working Group Leader of Task 7.1D will continue to provide oversight for this project.

Anspaugh, L.R.; Hendrickson, S.M. [eds.] [Lawrence Livermore National Lab., CA (United States); Hoffman, F.O. [Senes Oak Ridge, Inc., TN (United States). Center for Risk Analysis

1994-06-01T23:59:59.000Z

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421

Subchronic exposure to low-doses of the nerve agent VX: Physiological, behavioral, histopathological and neurochemical studies  

SciTech Connect

The highly toxic organophosphorous compound VX [O-ethyl-S-(isoporopylaminoethyl) methyl phosphonothiolate] undergoes an incomplete decontamination by conventional chemicals and thus evaporates from urban surfaces, e.g., pavement, long after the initial insult. As a consequence to these characteristics of VX, even the expected low levels should be examined for their potential to induce functional impairments including those associated with neuronal changes. In the present study, we developed an animal model for subchronic, low-dose VX exposure and evaluated its effects in rats. Animals were exposed to VX (2.25 {mu}g/kg/day, 0.05 LD{sub 50}) for three months via implanted mini osmotic pumps. The rapidly attained continuous and marked whole-blood cholinesterase inhibition ({approx} 60%), fully recovered 96 h post pump removal. Under these conditions, body weight, blood count and chemistry, water maze acquisition task, sensitivity to the muscarinic agonist oxotremorine, peripheral benzodiazepine receptors density and brain morphology as demonstrated by routine histopathology, remained unchanged. However, animals treated with VX showed abnormal initial response in an Open Field test and a reduction ({approx} 30%) in the expression of the exocytotic synaptobrevin/vesicle associate membrane prot