National Library of Energy BETA

Sample records for domain shows ring-shaped

  1. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Print Monday, 28 November 2011 14:52 Movement is fundamental to life. It...

  2. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Print Movement is fundamental to life. It takes place even at the cellular level where cargo is continually being transported...

  3. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Print Monday, 28 November 2011 14:52 Movement is fundamental to life. It takes place even at the cellular level where cargo is continually being transported by motor proteins. These tiny machines convert the energy gained from hydrolysing ATP into a series of small conformational changes that allow them to literally "walk" along microscopic tracks. Motor proteins (in the kinesin

  4. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Print Movement is fundamental to life. It takes place even at the cellular level where cargo is continually being transported by motor proteins. These tiny machines convert the energy gained from hydrolysing ATP into a series of small conformational changes that allow them to literally "walk" along microscopic tracks. Motor proteins (in the kinesin and myosin families) have been extensively studied by x-ray crystallography, but

  5. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Print Movement is fundamental to life. It takes place even at the cellular level where cargo is continually being transported by motor proteins. These tiny machines convert the energy gained from hydrolysing ATP into a series of small conformational changes that allow them to literally "walk" along microscopic tracks. Motor proteins (in the kinesin and myosin families) have been extensively studied by x-ray crystallography, but

  6. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Print Movement is fundamental to life. It takes place even at the cellular level where cargo is continually being transported by motor proteins. These tiny machines convert the energy gained from hydrolysing ATP into a series of small conformational changes that allow them to literally "walk" along microscopic tracks. Motor proteins (in the kinesin and myosin families) have been extensively studied by x-ray crystallography, but

  7. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Print Movement is fundamental to life. It takes place even at the cellular level where cargo is continually being transported by motor proteins. These tiny machines convert the energy gained from hydrolysing ATP into a series of small conformational changes that allow them to literally "walk" along microscopic tracks. Motor proteins (in the kinesin and myosin families) have been extensively studied by x-ray crystallography, but

  8. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Print Movement is fundamental to life. It takes place even at the cellular level where cargo is continually being transported by motor proteins. These tiny machines convert the energy gained from hydrolysing ATP into a series of small conformational changes that allow them to literally "walk" along microscopic tracks. Motor proteins (in the kinesin and myosin families) have been extensively studied by x-ray crystallography, but

  9. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dynein Motor Domain Shows Ring-Shaped Motor, Buttress Print Movement is fundamental to life. It takes place even at the cellular level where cargo is continually being transported by motor proteins. These tiny machines convert the energy gained from hydrolysing ATP into a series of small conformational changes that allow them to literally "walk" along microscopic tracks. Motor proteins (in the kinesin and myosin families) have been extensively studied by x-ray crystallography, but

  10. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    But the yield of protein from yeast was low, prompting researchers to try fed-batch fermentation, an approach used to make commercial yeast. In this method, a sugar solution is fed...

  11. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    normal density. A 75-liter fed-batch growth produced 14 kg of yeast and required a new freezer be purchased to store it all. With this massive increase in starting material, enough...

  12. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    normal density. A 75-liter fed-batch growth produced 14 kg of yeast and required a new freezer be purchased to store it all. With this massive increase in starting material,...

  13. Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    feature called the buttress that may play an important role in dynein's mechanical cycle. Yeast Yields Enable Protein Study The transportation of materials around a cell is...

  14. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Print Wednesday, 28 April 2010 00:00 Hexameric motor proteins represent a complex class of molecular machines that variously push and pull on biological molecules using adenosine triphosphate (ATP) as chemical fuel. A specialized class of ring-shaped motor proteins, hexameric helicases, can unwind DNA strands and perform large-scale manipulations of single-stranded

  15. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Print Hexameric motor proteins represent a complex class of molecular machines that variously push and pull on...

  16. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Print Hexameric motor proteins represent a complex class of molecular machines that variously push and pull on biological molecules using adenosine triphosphate (ATP) as chemical fuel. A specialized class of ring-shaped motor proteins, hexameric helicases, can unwind DNA strands and perform large-scale manipulations of single-stranded nucleic acids in processes such as DNA replication, DNA repair, and gene expression. To understand

  17. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Print Hexameric motor proteins represent a complex class of molecular machines that variously push and pull on biological molecules using adenosine triphosphate (ATP) as chemical fuel. A specialized class of ring-shaped motor proteins, hexameric helicases, can unwind DNA strands and perform large-scale manipulations of single-stranded nucleic acids in processes such as DNA replication, DNA repair, and gene expression. To understand

  18. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Print Hexameric motor proteins represent a complex class of molecular machines that variously push and pull on biological molecules using adenosine triphosphate (ATP) as chemical fuel. A specialized class of ring-shaped motor proteins, hexameric helicases, can unwind DNA strands and perform large-scale manipulations of single-stranded nucleic acids in processes such as DNA replication, DNA repair, and gene expression. To understand

  19. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Print Hexameric motor proteins represent a complex class of molecular machines that variously push and pull on biological molecules using adenosine triphosphate (ATP) as chemical fuel. A specialized class of ring-shaped motor proteins, hexameric helicases, can unwind DNA strands and perform large-scale manipulations of single-stranded nucleic acids in processes such as DNA replication, DNA repair, and gene expression. To understand

  20. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Print Hexameric motor proteins represent a complex class of molecular machines that variously push and pull on biological molecules using adenosine triphosphate (ATP) as chemical fuel. A specialized class of ring-shaped motor proteins, hexameric helicases, can unwind DNA strands and perform large-scale manipulations of single-stranded nucleic acids in processes such as DNA replication, DNA repair, and gene expression. To understand

  1. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Print Hexameric motor proteins represent a complex class of molecular machines that variously push and pull on biological molecules using adenosine triphosphate (ATP) as chemical fuel. A specialized class of ring-shaped motor proteins, hexameric helicases, can unwind DNA strands and perform large-scale manipulations of single-stranded nucleic acids in processes such as DNA replication, DNA repair, and gene expression. To understand

  2. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Print Hexameric motor proteins represent a complex class of molecular machines that variously push and pull on biological molecules using adenosine triphosphate (ATP) as chemical fuel. A specialized class of ring-shaped motor proteins, hexameric helicases, can unwind DNA strands and perform large-scale manipulations of single-stranded nucleic acids in processes such as DNA replication, DNA repair, and gene expression. To understand

  3. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rotary Firing in Ring-Shaped Protein Explains Unidirectionality Print Hexameric motor proteins represent a complex class of molecular machines that variously push and pull on biological molecules using adenosine triphosphate (ATP) as chemical fuel. A specialized class of ring-shaped motor proteins, hexameric helicases, can unwind DNA strands and perform large-scale manipulations of single-stranded nucleic acids in processes such as DNA replication, DNA repair, and gene expression. To understand

  4. Cell culture arrays using micron-sized ferromagnetic ring-shaped thin films

    SciTech Connect (OSTI)

    Huang, Chen-Yu; Wei, Zung-Hang; Lai, Mei-Feng; Ger, Tzong-Rong

    2015-05-07

    Cell patterning has become an important technology for tissue engineering. In this research, domain walls are formed at the two ends of a ferromagnetic ring thin film after applying a strong external magnetic field, which can effectively attract magnetically labeled cells and control the position for biological cell. Magnetophoresis experiment was conducted to quantify the magnetic nanoparticle inside the cells. A ring-shaped magnetic thin films array was fabricated through photolithography. It is observed that magnetically labeled cells can be successfully attracted to the two ends of the ring-shaped magnetic thin film structure and more cells were attracted and further attached to the structures. The cells are co-cultured with the structure and kept proliferating; therefore, such ring thin film can be an important candidate for in-vitro biomedical chips or tissue engineering.

  5. Electromagnetic wave attenuation measurements in a ring-shaped inductively coupled air plasma

    SciTech Connect (OSTI)

    Xiaolong, Wei; Haojun, Xu; Min, Lin; Chen, Su; Jianhai, Li

    2015-05-28

    An aerocraft with the surface, inlet and radome covered large-area inductive coupled plasma (ICP) can attenuate its radar echo effectively. The shape, thickness, and electron density (N{sub e}) distribution of ICP are critical to electromagnetic wave attenuation. In the paper, an air all-quartz ICP generator in size of 20 × 20 × 7 cm{sup 3} without magnetic confinement is designed. The discharge results show that the ICP is amorphous in E-mode and ring-shaped in H-mode. The structure of ICP stratifies into core region and edge halo in H-mode, and its width and thickness changes from power and pressure. Such phenomena are explained by the distribution of RF magnetic field, the diffusion of negative ions plasma and the variation of skin depth. In addition, the theoretical analysis shows that the N{sub e} achieves nearly uniform within the electronegative core and sharply steepens in the edge. The N{sub e} of core region is diagnosed by microwave interferometer under varied conditions (pressure in range of 10–50 Pa, power in 300–700 W). Furthermore, the electromagnetic wave attenuation measurements were carried out with the air ICP in the frequencies of 4–5 GHz. The results show that the interspaced ICP is still effective to wave attenuation, and the wave attenuation increases with the power and pressure. The measured attenuation is approximately in accordance with the calculation data of finite-different time-domain simulations.

  6. Ring-shaped polariton lasing in pillar microcavities

    SciTech Connect (OSTI)

    Kalevich, V. K. Afanasiev, M. M.; Lukoshkin, V. A.; Kavokin, K. V.; Tsintzos, S. I.; Savvidis, P. G.; Kavokin, A. V.

    2014-03-07

    Optically generated exciton-polaritons in cylindric semiconductor pillar microcavity with embedded GaAs/AlGaAs quantum wells demonstrate a clear polariton lasing regime. When exciting in the center of the pillar, we detect a ring-shaped emission, where the peak of intensity can be separated from the excitation spot by more than 10 ?m. The spatial coherence of the ring emission is verified by interferometry measurements. These observations are interpreted by drift of the exciton polariton condensate away from the excitation spot due to its repulsion from the exciton reservoir and by its spatial confinement by the pillar boundary.

  7. Trapping two types of particles using a double-ring-shaped radially polarized beam

    SciTech Connect (OSTI)

    Zhang Yaoju; Ding Biaofeng; Suyama, Taikei

    2010-02-15

    An optical-trap method based on the illumination of a double-ring-shaped radially polarized beam (R-TEM{sub 11}*) is proposed. The numerical results based on the vector diffraction theory show that a highly focused R-TEM{sub 11}* beam not only can produce a bright spot but also can form an optical cage in the focal region by changing the truncation parameter {beta}, defined as the ratio of the radius of the aperture to the waist of the beam. The radiation forces acting on Rayleigh particles are calculated by using the Rayleigh scattering theory. The bright spot generated by the R-TEM{sub 11}* beam with a {beta} value close to 2 can three-dimensionally trap a particle with a refractive index larger than that of the ambient. An optical cage or three-dimensional dark spot generated by the R-TEM{sub 11}* beam with a {beta} value close to 1.3 can three-dimensionally trap a particle with refractive index smaller than that of the ambient. Because the adjustment of the truncation parameter can be actualized by simply changing the radius of a circular aperture inserted in the front of the lens, only one optical-trap system in the present method can be used to three-dimensionally trap two types of particles with different refractive indices.

  8. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    structure of a hexameric helicase, the Rho transcription termination factor (from E. coli), bound to both ATP mimics and an RNA substrate. The results showed that Rho functions...

  9. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the structure of a hexameric helicase, the Rho transcription termination factor (from E. coli), bound to both ATP mimics and an RNA substrate. The results showed that Rho...

  10. Electrodynamics of a ring-shaped spiral resonator

    SciTech Connect (OSTI)

    Maleeva, N.; Karpov, A.; Averkin, A.; Fistul, M. V.; Zhuravel, A. P.; Jung, P.; Ustinov, A. V.

    2014-02-14

    We present analytical, numerical, and experimental investigations of electromagnetic resonant modes of a compact monofilar Archimedean spiral resonator shaped in a ring, with no central part. Planar spiral resonators are interesting as components of metamaterials for their compact deep-subwavelength size. Such resonators couple primarily to the magnetic field component of the incident electromagnetic wave, offering properties suitable for magnetic meta-atoms. Surprisingly, the relative frequencies of the resonant modes follow the sequence of the odd numbers as f{sub 1}:f{sub 2}:f{sub 3}:f{sub 4}… = 1:3:5:7…, despite the nearly identical boundary conditions for electromagnetic fields at the extremities of the resonator. In order to explain the observed spectrum of resonant modes, we show that the current distribution inside the spiral satisfies a particular Carleman type singular integral equation. By solving this equation, we obtain a set of resonant frequencies. The analytically calculated resonance frequencies and the current distributions are in good agreement with experimental data and the results of numerical simulations. By using low-temperature laser scanning microscopy of a superconducting spiral resonator, we compare the experimentally visualized ac current distributions over the spiral with the calculated ones. Theory and experiment agree well with each other. Our analytical model allows for calculation of a detailed three-dimensional magnetic field structure of the resonators.

  11. Peculiarity of convergence of shock wave generated by underwater electrical explosion of ring-shaped wire

    SciTech Connect (OSTI)

    Shafer, D.; Toker, G. R.; Gurovich, V. Tz.; Gleizer, S.; Krasik, Ya. E.

    2013-05-15

    Nanosecond timescale underwater electrical wire explosions of ring-shaped Cu wires were investigated using a pulsed generator with a current amplitude up to 50 kA. It was shown that this type of wire explosion results in the generation of a toroidal shock wave (SW). Time- and space-resolved optical diagnostics were used to determine azimuthal uniformity of the shock wave front and its velocity. It was found that the shock wave preserves its circular front shape in the range of radii 50?m

  12. Wedding ring shaped excitation coil

    DOE Patents [OSTI]

    MacLennan, Donald A.; Tsai, Peter

    2001-01-01

    A high frequency inductively coupled electrodeless lamp includes an excitation coil with an effective electrical length which is less than one half wavelength of a driving frequency applied thereto, preferably much less. The driving frequency may be greater than 100 MHz and is preferably as high as 915 MHz. Preferably, the excitation coil is configured as a non-helical, semi-cylindrical conductive surface having less than one turn, in the general shape of a wedding ring. At high frequencies, the current in the coil forms two loops which are spaced apart and parallel to each other. Configured appropriately, the coil approximates a Helmholtz configuration. The lamp preferably utilizes an bulb encased in a reflective ceramic cup with a pre-formed aperture defined therethrough. The ceramic cup may include structural features to aid in alignment and/or a flanged face to aid in thermal management. The lamp head is preferably an integrated lamp head comprising a metal matrix composite surrounding an insulating ceramic with the excitation integrally formed on the ceramic. A novel solid-state oscillator preferably provides RF power to the lamp. The oscillator is a single active element device capable of providing over 70 watts of power at over 70% efficiency.

  13. Light Show

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9 Lightning - Nature's Light Show Lightning provides one of nature's most spectacular displays of energy. Though fascinating to observe, lightning can be dangerous and deadly....

  14. Employee Show

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Where Science Inspires Art Fermilab Employee Art Show 2015 Exhibition Dates -September 18, 2015 November 30, 2015 Reception - September 23, 2015 5 7pm Eligibility: Any current...

  15. Magnetic domain wall manipulation in (Ga,Mn)As nanostructures for spintronic applications

    SciTech Connect (OSTI)

    Wosinski, Tadeusz; Andrearczyk, Tomasz; Figielski, Tadeusz; Olender, Karolina; Wrobel, Jerzy

    2014-02-21

    Ring-shaped nanostructures have been designed and fabricated by electron-beam lithography patterning and chemical etching from thin epitaxial layers of the ferromagnetic semiconductor (Ga,Mn)As. The nanostructures, in a form of planar rings with a slit, were supplied with four electrical terminals and subjected to magneto-transport studies under planar weak magnetic field. Magnetoresistive effects caused by manipulation of magnetic domain walls and magnetization reversal in the nanostructures have been investigated and possible applications of the nanostructures as four-terminal spintronic devices are discussed.

  16. Critical role of domain crystallinity, domain purity and domain interface

    Office of Scientific and Technical Information (OSTI)

    sharpness for reduced bimolecular recombination in polymer solar cells (Journal Article) | SciTech Connect Critical role of domain crystallinity, domain purity and domain interface sharpness for reduced bimolecular recombination in polymer solar cells Citation Details In-Document Search This content will become publicly available on March 30, 2017 Title: Critical role of domain crystallinity, domain purity and domain interface sharpness for reduced bimolecular recombination in polymer solar

  17. Post-Show Tips

    Broader source: Energy.gov [DOE]

    These guidelines are designed to help you with the post-show process. This page includes tips for tearing down your exhibit, shipping the exhibit, and collecting your bills.

  18. Show Me PACE

    Broader source: Energy.gov [DOE]

    In July 2010 Missouri enacted the Property Assessed Clean Energy Act. In June 2015, Show Me PACE was established under this law as a Clean Energy Development Board. PACE financing allows property...

  19. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    perform large-scale manipulations of single-stranded nucleic acids in processes such as DNA replication, DNA repair, and gene expression. To understand how certain hexameric...

  20. Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    manipulations of single-stranded nucleic acids in processes such as DNA replication, DNA repair, and gene expression. To understand how certain hexameric helicases walk with...

  1. Guidelines for Supplier, Vendor Shows

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Guidelines for Supplier, Vendor Shows Guidelines for SupplierVendor or Professional Local Trade FairsShows As a premier national research and development laboratory, LANL seeks...

  2. Show Tips | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Show Tips Show Tips These guidelines are designed to help you prepare for exhibiting. Be sure that you are fully prepared before the event begins. Get Your Badge You will need a ...

  3. Backstage at the Daily Show

    Broader source: Energy.gov [DOE]

    Backstage footage from Secretary Chu's appearance on the Daily Show where he discuses the green room candy dish and possible lighting considerations.

  4. Slow Dynamics of Orbital Domains in Manganite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    we can understand the movement of the electronic domain structure. A typical image from a digital camera for x rays (CCD) showing a soft x-ray speckle pattern. The close-up...

  5. ShowMe3D

    Energy Science and Technology Software Center (OSTI)

    2012-01-05

    ShowMe3D is a data visualization graphical user interface specifically designed for use with hyperspectral image obtained from the Hyperspectral Confocal Microscope. The program allows the user to select and display any single image from a three dimensional hyperspectral image stack. By moving a slider control, the user can easily move between images of the stack. The user can zoom into any region of the image. The user can select any pixel or region from themore » displayed image and display the fluorescence spectrum associated with that pixel or region. The user can define up to 3 spectral filters to apply to the hyperspectral image and view the image as it would appear from a filter-based confocal microscope. The user can also obtain statistics such as intensity average and variance from selected regions.« less

  6. Cytoplasmic Domain Structures of Kir2.1 and Kir3.1 Shows Sites...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in yellow merged with KirBac1.1 transmembrane region's backbone and surface in gray. The gate forming tip of the G-loop, amino acids 304-306, is highlighted in red. The...

  7. Jamming Behavior of Domains in a Spiral Antiferromagnetic System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Jamming Behavior of Domains in a Spiral Antiferromagnetic System Jamming Behavior of Domains in a Spiral Antiferromagnetic System Print Tuesday, 04 June 2013 13:34 This schematic of x-ray scattering is from a spiral antiferromagnet with a spin structure that gives rise to domains with jamming behavior. Using resonant magnetic x-ray photon correlation spectroscopy, this research shows that the domains of a spiral antiferromagnet enter a jammed state at the onset of long-range order. Researchers

  8. Axion domain wall baryogenesis

    SciTech Connect (OSTI)

    Daido, Ryuji; Kitajima, Naoya; Takahashi, Fuminobu

    2015-07-28

    We propose a new scenario of baryogenesis, in which annihilation of axion domain walls generates a sizable baryon asymmetry. Successful baryogenesis is possible for a wide range of the axion mass and decay constant, m≃10{sup 8}–10{sup 13} GeV and f≃10{sup 13}–10{sup 16} GeV. Baryonic isocurvature perturbations are significantly suppressed in our model, in contrast to various spontaneous baryogenesis scenarios in the slow-roll regime. In particular, the axion domain wall baryogenesis is consistent with high-scale inflation which generates a large tensor-to-scalar ratio within the reach of future CMB B-mode experiments. We also discuss the gravitational waves produced by the domain wall annihilation and its implications for the future gravitational wave experiments.

  9. Cellulose binding domain proteins

    DOE Patents [OSTI]

    Shoseyov, Oded; Shpiegl, Itai; Goldstein, Marc; Doi, Roy

    1998-01-01

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.

  10. Cellulose binding domain proteins

    DOE Patents [OSTI]

    Shoseyov, O.; Shpiegl, I.; Goldstein, M.; Doi, R.

    1998-11-17

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques. 16 figs.

  11. Assembling a ring-shaped crystal in a microfabricated surface ion trap

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Stick, Daniel Lynn; Univ. of New Mexico, Albuquerque, NM; Tabakov, Boyan; Univ. of New Mexico, Albuquerque, NM; Benito, Francisco; Blain, Matthew; Clark, Craig R.; Clark, Susan; Haltli, Raymond A.; Maunz, Peter; et al

    2015-09-01

    We report on experiments with a microfabricated surface trap designed for confining a chain of ions in a ring. Uniform ion separation over most of the ring is achieved with a rotationally symmetric design and by measuring and suppressing undesired electric fields. After reducing stray fields, the ions are confined primarily by a radio-frequency pseudopotential and their mutual Coulomb repulsion. As a result, approximately 400 40Ca+ ions with an average separation of 9 μm comprise the ion crystal.

  12. Assembling a ring-shaped crystal in a microfabricated surface ion trap

    SciTech Connect (OSTI)

    Stick, Daniel Lynn; Tabakov, Boyan; Benito, Francisco; Blain, Matthew; Clark, Craig R.; Clark, Susan; Haltli, Raymond A.; Maunz, Peter; Sterk, Jonathan D.; Tigges, Chris

    2015-09-01

    We report on experiments with a microfabricated surface trap designed for confining a chain of ions in a ring. Uniform ion separation over most of the ring is achieved with a rotationally symmetric design and by measuring and suppressing undesired electric fields. After reducing stray fields, the ions are confined primarily by a radio-frequency pseudopotential and their mutual Coulomb repulsion. As a result, approximately 400 40Ca+ ions with an average separation of 9 μm comprise the ion crystal.

  13. Internal stress distribution for generating closure domains in laser-irradiated Fe3%Si(110) steels

    SciTech Connect (OSTI)

    Iwata, Keiji; Imafuku, Muneyuki; Orihara, Hideto; Sakai, Yusuke; Ohya, Shin-Ichi; Suzuki, Tamaki; Shobu, Takahisa; Akita, Koichi; Ishiyama, Kazushi

    2015-05-07

    Internal stress distribution for generating closure domains occurring in laser-irradiated Fe3%Si(110) steels was investigated using high-energy X-ray analysis and domain theory based on the variational principle. The measured triaxial stresses inside the specimen were compressive and the stress in the rolling direction became more dominant than stresses in the other directions. The calculations based on the variational principle of magnetic energy for closure domains showed that the measured triaxial stresses made the closure domains more stable than the basic domain without closure domains. The experimental and calculation results reveal that the laser-introduced internal stresses result in the occurrence of the closure domains.

  14. Show Me Ethanol LLC | Open Energy Information

    Open Energy Info (EERE)

    Show Me Ethanol LLC Jump to: navigation, search Name: Show Me Ethanol, LLC Place: Carrollton, Missouri Zip: 64633 Product: Developing an ethanol project in Carrollton, Missouri....

  15. Detroit Auto Show 2012 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Detroit Auto Show 2012 Detroit Auto Show 2012 Addthis 1 of 10 Energy Secretary Steven Chu with Chrysler Chief Executive Sergio Marchionne. Image: Hantz Leger (Energy Department ...

  16. Fractional diffusion on bounded domains

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Defterli, Ozlem; D'Elia, Marta; Du, Qiang; Gunzburger, Max Donald; Lehoucq, Richard B.; Meerschaert, Mark M.

    2015-03-13

    We found that the mathematically correct specification of a fractional differential equation on a bounded domain requires specification of appropriate boundary conditions, or their fractional analogue. In this paper we discuss the application of nonlocal diffusion theory to specify well-posed fractional diffusion equations on bounded domains.

  17. The Paris Motor Show | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The Paris Motor Show The Paris Motor Show October 4, 2010 - 9:39am Addthis David Sandalow at the Paris Auto Show | DOE photo David Sandalow at the Paris Auto Show | DOE photo David Sandalow David Sandalow Former Under Secretary of Energy (Acting) and Assistant Secretary for Policy & International Affairs At the Paris Motor Show today, electric cars are everywhere. Chevrolet is showing off the Volt, its plug-in hybrid due in U.S. showrooms this December. (Motown music blared as a Chevy rep

  18. Laser research shows promise for cancer treatment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer treatment Laser research shows promise for cancer treatment Scientists have observed for the first time how a laser penetrates dense, electron-rich plasma to generate ions. ...

  19. Structural and Evolutionary Analyses Show Unique Stabilization...

    Office of Scientific and Technical Information (OSTI)

    Title: Structural and Evolutionary Analyses Show Unique Stabilization Strategies in the Type IV Pili of Clostridium difficile Authors: Piepenbrink, Kurt H. ; Maldarelli, Grace A. ; ...

  20. DOE Booth Presentations From Grainger Show 2015

    Broader source: Energy.gov [DOE]

    DOE hosted its solid-state lighting informational booth February 16–18 at the annual Grainger Show in Orlando, FL. With over 17,000 attendees and over 750 exhibitors, the show gathered a wide range of Grainger customers—from universities to large hotel chains as well as Grainger team members to learn the latest about LED lighting.

  1. Particle Communication and Domain Neighbor Coupling: Scalable Domain Decomposed Algorithms for Monte Carlo Particle Transport

    SciTech Connect (OSTI)

    O'Brien, M J; Brantley, P S

    2015-01-20

    In order to run Monte Carlo particle transport calculations on new supercomputers with hundreds of thousands or millions of processors, care must be taken to implement scalable algorithms. This means that the algorithms must continue to perform well as the processor count increases. In this paper, we examine the scalability of:(1) globally resolving the particle locations on the correct processor, (2) deciding that particle streaming communication has finished, and (3) efficiently coupling neighbor domains together with different replication levels. We have run domain decomposed Monte Carlo particle transport on up to 221 = 2,097,152 MPI processes on the IBM BG/Q Sequoia supercomputer and observed scalable results that agree with our theoretical predictions. These calculations were carefully constructed to have the same amount of work on every processor, i.e. the calculation is already load balanced. We also examine load imbalanced calculations where each domains replication level is proportional to its particle workload. In this case we show how to efficiently couple together adjacent domains to maintain within workgroup load balance and minimize memory usage.

  2. Thermal effects on transverse domain wall dynamics in magnetic nanowires

    SciTech Connect (OSTI)

    Leliaert, J.; Van de Wiele, B.; Vandermeulen, J.; Coene, A.; Dupré, L.; Vansteenkiste, A.; Waeyenberge, B. Van; Laurson, L.; Durin, G.

    2015-05-18

    Magnetic domain walls are proposed as data carriers in future spintronic devices, whose reliability depends on a complete understanding of the domain wall motion. Applications based on an accurate positioning of domain walls are inevitably influenced by thermal fluctuations. In this letter, we present a micromagnetic study of the thermal effects on this motion. As spin-polarized currents are the most used driving mechanism for domain walls, we have included this in our analysis. Our results show that at finite temperatures, the domain wall velocity has a drift and diffusion component, which are in excellent agreement with the theoretical values obtained from a generalized 1D model. The drift and diffusion component are independent of each other in perfect nanowires, and the mean square displacement scales linearly with time and temperature.

  3. 2016 Washington Auto Show | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Washington Auto Show 2016 Washington Auto Show Addthis 1 of 20 Energy Secretary Ernest Moniz sits in the driver's seat of the all-electric Chevrolet Bolt at the Washington Auto Show. When it debuts on the road later this year, the Bolt will offer drivers about 200 miles of electric range. Image: Simon Edelman, Energy Department Date taken: 2016-01-21 09:45 2 of 20 The 2016 next-generation Chevrolet Volt builds on the success of its previous version, which was the first plug-in hybrid electric

  4. 2013 Washington Auto Show | Department of Energy

    Energy Savers [EERE]

    Washington Auto Show 2013 Washington Auto Show Addthis 1 of 10 While at the Washington Auto Show, Energy Secretary Steven Chu visited Nissan to see the 2013 Leaf. | Photo courtesy of Sarah Gerrity, Energy Department. Date taken: 2013-01-31 13:50 2 of 10 The new Nissan Leaf is being built at the company's Smyrna, Tennessee, Vehicle Assembly Plant -- helping to cut the price of its electric vehicle. | Photo courtesy of Sarah Gerrity, Energy Department. Date taken: 2013-01-31 13:49 3 of 10 Energy

  5. 2015 Washington Auto Show | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    5 Washington Auto Show 2015 Washington Auto Show Addthis Moniz Delivers Keynote Remarks 1 of 10 Moniz Delivers Keynote Remarks Secretary Moniz touted the Department's investments in advanced vehicle technologies, infrastructure and manufacturing. Photo by Sarah Gerrity Date taken: 2015-01-22 04:33 Secretary Moniz Announces More than $55M in Fuel-Efficient Vehicle Funding 2 of 10 Secretary Moniz Announces More than $55M in Fuel-Efficient Vehicle Funding The funding opportunities will go towards a

  6. Geothermal Energy Featured on NBC's Today Show

    Broader source: Energy.gov [DOE]

    In Iceland, there are five major geothermal power plants which produce about 26% (2006) of the country's electricity. In addition, geothermal heating meets the heating and hot water requirements for around 87% of the nation's buildings. As part of its "Ends of the Earth" series, NBC's Today Show presented a feature on the use of geothermal energy in Iceland.

  7. Gasoline price shows small increase (Short version)

    U.S. Energy Information Administration (EIA) Indexed Site

    shows small increase (Short version) The U.S. average retail price for regular gasoline rose to $3.32 a gallon on Monday. That's up 1.2 cents from a week ago, based on the weekly price survey by the U.S. Energy Information Administration.

  8. Gasoline price shows small increase (short version)

    U.S. Energy Information Administration (EIA) Indexed Site

    Short version) The U.S. average retail price for regular gasoline showed little movement from last week. Prices rose 4/10 of a cent to $3.30 a gallon on Monday, based on the weekly price survey by the U.S. Energy Information Administration.

  9. Gasoline price shows small increase (long version)

    U.S. Energy Information Administration (EIA) Indexed Site

    long version) The U.S. average retail price for regular gasoline showed little movement from last week. Prices rose 4/10 of a cent to $3.30 a gallon on Monday, based on the weekly price survey by the U.S. Energy Information Administration. Pump prices were highest in the New England States, at 3.52 a gallon, down 1/10 of a penny from a week ago. Prices were lowest at 2.87 a gallon in the Rocky Mountain States, with the biggest regional price drop at close to 7 cents.

  10. Cellulose binding domain fusion proteins

    DOE Patents [OSTI]

    Shoseyov, O.; Yosef, K.; Shpiegl, I.; Goldstein, M.A.; Doi, R.H.

    1998-02-17

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques. 16 figs.

  11. Cellulose binding domain fusion proteins

    DOE Patents [OSTI]

    Shoseyov, Oded; Shpiegl, Itai; Goldstein, Marc A.; Doi, Roy H.

    1998-01-01

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.

  12. Slow Dynamics of Orbital Domains in Manganite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Slow Dynamics of Orbital Domains in Manganite Slow Dynamics of Orbital Domains in Manganite Print Wednesday, 25 June 2008 00:00 At the ALS, an international team of researchers has...

  13. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hidden Rotational Symmetries in Magnetic Domain Patterns Hidden Rotational Symmetries in Magnetic Domain Patterns Print Wednesday, 27 June 2012 00:00 Magnetic thin films have complicated domain patterns that may or may not repeat with each cycle through a hysteresis loop. A magnetic thin film with perpendicular anisotropy, such as that used in computer hard drives, for example, commonly exhibits labyrinthine domain patterns. These patterns are disordered over a macroscopic length scale, and

  14. Domain wall conduction in multiaxial ferroelectrics

    SciTech Connect (OSTI)

    Eliseev, E. A.; Morozovska, A. N.; Svechnikov, S. V.; Maksymovych, Petro; Kalinin, Sergei V

    2012-01-01

    The conductance of domain wall structures consisting of either stripes or cylindrical domains in multiaxial ferroelectric-semiconductors is analyzed. The effects of the flexoelectric coupling, domain size, wall tilt, and curvature on charge accumulation are analyzed using the Landau-Ginsburg Devonshire theory for polarization vector combined with the Poisson equation for charge distributions. The proximity and size effect of the electron and donor accumulation/depletion by thin stripe domains and cylindrical nanodomains are revealed. In contrast to thick domain stripes and wider cylindrical domains, in which the carrier accumulation (and so the static conductivity) sharply increases at the domain walls only, small nanodomains of radii less than 5-10 correlation lengths appeared conducting across the entire cross-section. Implications of such conductive nanosized channels may be promising for nanoelectronics.

  15. Time domain electromagnetic metal detectors

    SciTech Connect (OSTI)

    Hoekstra, P.

    1996-04-01

    This presentation focuses on illustrating by case histories the range of applications and limitations of time domain electromagnetic (TDEM) systems for buried metal detection. Advantages claimed for TDEM metal detectors are: independent of instrument response (Geonics EM61) to surrounding soil and rock type; simple anomaly shape; mitigation of interference by ambient electromagnetic noise; and responsive to both ferrous and non-ferrous metallic targets. The data in all case histories to be presented were acquired with the Geonics EM61 TDEM system. Case histories are a test bed site on Molokai, Hawaii; Fort Monroe, Virginia; and USDOE, Rocky Flats Plant. The present limitations of this technology are: discrimination capabilities in terms of type of ordnance, and depth of burial is limited, and ability of resolving targets with small metallic ambient needs to be improved.

  16. Haem Recognition By a Staphylococcus Aureus NEAT Domain

    SciTech Connect (OSTI)

    Grigg, J.C.; Vermeiren, C.; Heinrichs, D.E.; Murphy, M.E.P.

    2009-06-01

    Successful pathogenic organisms have developed mechanisms to thrive under extreme levels of iron restriction. Haem-iron represents the largest iron reservoir in the human body and is a significant source of iron for some bacterial pathogens. NEAT (NEAr Transporter) domains are found exclusively in a family of cell surface proteins in Gram-positive bacteria. Many NEAT domain-containing proteins, including IsdA in Staphylococcus aureus, are implicated in haem binding. Here, we show that overexpression of IsdA in S. aureus enhances growth and an inactivation mutant of IsdA has a growth defect, compared with wild type, when grown in media containing haem as the sole iron source. Furthermore, the haem-binding property of IsdA is contained within the NEAT domain. Crystal structures of the apo-IsdA NEAT domain and in complex with haem were solved and reveal a clathrin adapter-like beta-sandwich fold with a large hydrophobic haem-binding pocket. Haem is bound with the propionate groups directed at the molecular surface and the iron is co-ordinated solely by Tyr(166). The phenol groups of Tyr(166) and Tyr(170) form an H-bond that may function in regulating haem binding and release. An analysis of IsdA structure-sequence alignments indicate that conservation of Tyr(166) is a predictor of haem binding by NEAT domains.

  17. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hidden Rotational Symmetries in Magnetic Domain Patterns Print Magnetic thin films have complicated domain patterns that may or may not repeat with each cycle through a hysteresis loop. A magnetic thin film with perpendicular anisotropy, such as that used in computer hard drives, for example, commonly exhibits labyrinthine domain patterns. These patterns are disordered over a macroscopic length scale, and intuitively we do not expect to observe any symmetry in such systems. Scientists at the

  18. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hidden Rotational Symmetries in Magnetic Domain Patterns Print Magnetic thin films have complicated domain patterns that may or may not repeat with each cycle through a hysteresis loop. A magnetic thin film with perpendicular anisotropy, such as that used in computer hard drives, for example, commonly exhibits labyrinthine domain patterns. These patterns are disordered over a macroscopic length scale, and intuitively we do not expect to observe any symmetry in such systems. Scientists at the

  19. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hidden Rotational Symmetries in Magnetic Domain Patterns Print Magnetic thin films have complicated domain patterns that may or may not repeat with each cycle through a hysteresis loop. A magnetic thin film with perpendicular anisotropy, such as that used in computer hard drives, for example, commonly exhibits labyrinthine domain patterns. These patterns are disordered over a macroscopic length scale, and intuitively we do not expect to observe any symmetry in such systems. Scientists at the

  20. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hidden Rotational Symmetries in Magnetic Domain Patterns Print Magnetic thin films have complicated domain patterns that may or may not repeat with each cycle through a hysteresis loop. A magnetic thin film with perpendicular anisotropy, such as that used in computer hard drives, for example, commonly exhibits labyrinthine domain patterns. These patterns are disordered over a macroscopic length scale, and intuitively we do not expect to observe any symmetry in such systems. Scientists at the

  1. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hidden Rotational Symmetries in Magnetic Domain Patterns Print Magnetic thin films have complicated domain patterns that may or may not repeat with each cycle through a hysteresis loop. A magnetic thin film with perpendicular anisotropy, such as that used in computer hard drives, for example, commonly exhibits labyrinthine domain patterns. These patterns are disordered over a macroscopic length scale, and intuitively we do not expect to observe any symmetry in such systems. Scientists at the

  2. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hidden Rotational Symmetries in Magnetic Domain Patterns Print Magnetic thin films have complicated domain patterns that may or may not repeat with each cycle through a hysteresis loop. A magnetic thin film with perpendicular anisotropy, such as that used in computer hard drives, for example, commonly exhibits labyrinthine domain patterns. These patterns are disordered over a macroscopic length scale, and intuitively we do not expect to observe any symmetry in such systems. Scientists at the

  3. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hidden Rotational Symmetries in Magnetic Domain Patterns Print Magnetic thin films have complicated domain patterns that may or may not repeat with each cycle through a hysteresis loop. A magnetic thin film with perpendicular anisotropy, such as that used in computer hard drives, for example, commonly exhibits labyrinthine domain patterns. These patterns are disordered over a macroscopic length scale, and intuitively we do not expect to observe any symmetry in such systems. Scientists at the

  4. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hidden Rotational Symmetries in Magnetic Domain Patterns Print Magnetic thin films have complicated domain patterns that may or may not repeat with each cycle through a hysteresis loop. A magnetic thin film with perpendicular anisotropy, such as that used in computer hard drives, for example, commonly exhibits labyrinthine domain patterns. These patterns are disordered over a macroscopic length scale, and intuitively we do not expect to observe any symmetry in such systems. Scientists at the

  5. Evolution of domain wall networks: The Press-Ryden-Spergel algorithm

    SciTech Connect (OSTI)

    Sousa, L.; Avelino, P. P.

    2010-04-15

    The Press-Ryden-Spergel (PRS) algorithm is a modification to the field theory equations of motion, parametrized by two parameters ({alpha} and {beta}), implemented in numerical simulations of cosmological domain wall networks, in order to ensure a fixed comoving resolution. In this paper we explicitly demonstrate that the PRS algorithm provides the correct domain wall dynamics in (N+1)-dimensional Friedmann-Robertson-Walker universes if {alpha}+{beta}/2=N, fully validating its use in numerical studies of cosmic domain evolution. We further show that this result is valid for generic thin featureless domain walls, independently of the Lagrangian of the model.

  6. Using Non-Government Domain Names

    Broader source: Energy.gov [DOE]

    There may be occasion where it is necessary to utilize a non-government domain. The OMB Policies for Federal Agency Public Websites  states:

  7. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A magnetic thin film with perpendicular anisotropy, such as that used in computer hard drives, for example, commonly exhibits labyrinthine domain patterns. These patterns are...

  8. A Geometric Rendezvous-Based Domain Model

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    University of Wisconsin - Madison 1500 Engineering Dr. Madison, WI 53716 sslattery@wisc.edu March 20, 2013 1 A Geometric Rendezvous-Based Domain Model for Data Transfer...

  9. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    California, San Diego, have recently used coherent soft x-ray scattering with angular Fourier analysis to discover that the disordered domain patterns do, in fact, exhibit...

  10. Development of Nonlinear SSI Time Domain Methodology

    Broader source: Energy.gov [DOE]

    Development of Nonlinear SSI Time Domain Methodology Justin Coleman, P.E. Nuclear Science and Technology Idaho National Laboratory October 22, 2014

  11. Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures

    SciTech Connect (OSTI)

    Pyklinen, Anette; Boczkowska, Malgorzata; Zhao, Hongxia; Saarikangas, Juha; Rebowski, Grzegorz; Jansen, Maurice; Hakanen, Janne; Koskela, Essi V.; Pernen, Johan; Vihinen, Helena; Jokitalo, Eija; Salminen, Marjo; Ikonen, Elina; Dominguez, Roberto; Lappalainen, Pekka

    2013-05-29

    Bin/amphipysin/Rvs (BAR)-domain proteins sculpt cellular membranes and have key roles in processes such as endocytosis, cell motility and morphogenesis. BAR domains are divided into three subfamilies: BAR- and F-BAR-domain proteins generate positive membrane curvature and stabilize cellular invaginations, whereas I-BAR-domain proteins induce negative curvature and stabilize protrusions. We show that a previously uncharacterized member of the I-BAR subfamily, Pinkbar, is specifically expressed in intestinal epithelial cells, where it localizes to Rab13-positive vesicles and to the plasma membrane at intercellular junctions. Notably, the BAR domain of Pinkbar does not induce membrane tubulation but promotes the formation of planar membrane sheets. Structural and mutagenesis analyses reveal that the BAR domain of Pinkbar has a relatively flat lipid-binding interface and that it assembles into sheet-like oligomers in crystals and in solution, which may explain its unique membrane-deforming activity.

  12. Optical coherence domain reflectometry guidewire

    DOE Patents [OSTI]

    Colston, Billy W. (Livermore, CA); Everett, Matthew (Pleasanton, CA); Da Silva, Luiz B. (Danville, CA); Matthews, Dennis (Moss Beach, CA)

    2001-01-01

    A guidewire with optical sensing capabilities is based on a multiplexed optical coherence domain reflectometer (OCDR), which allows it to sense location, thickness, and structure of the arterial walls or other intra-cavity regions as it travels through the body during minimally invasive medical procedures. This information will be used both to direct the guidewire through the body by detecting vascular junctions and to evaluate the nearby tissue. The guidewire contains multiple optical fibers which couple light from the proximal to distal end. Light from the fibers at the distal end of the guidewire is directed onto interior cavity walls via small diameter optics such as gradient index lenses and mirrored corner cubes. Both forward viewing and side viewing fibers can be included. The light reflected or scattered from the cavity walls is then collected by the fibers, which are multiplexed at the proximal end to the sample arm of an optical low coherence reflectometer. The guidewire can also be used in nonmedical applications.

  13. Automotion of domain walls for spintronic interconnects

    SciTech Connect (OSTI)

    Nikonov, Dmitri E.; Manipatruni, Sasikanth; Young, Ian A.

    2014-06-07

    We simulate “automotion,” the transport of a magnetic domain wall under the influence of demagnetization and magnetic anisotropy, in nanoscale spintronic interconnects. In contrast to spin transfer driven magnetic domain wall motion, the proposed interconnects operate without longitudinal charge current transfer, with only a transient current pulse at domain wall creation and have favorable scaling down to the 20 nm dimension. Cases of both in-plane and out-of-plane magnetization are considered. Analytical dependence of the velocity of domain walls on the angle of magnetization are compared with full micromagnetic simulations. Deceleration, attenuation and disappearance, and reflection of domain walls are demonstrated through simulation. Dependences of the magnetization angle on the current pulse parameters are studied. The energy and delay analysis suggests that automotion is an attractive option for spintronic logic interconnects.

  14. Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling

    SciTech Connect (OSTI)

    Achar, Yathish Jagadheesh; Balogh, David; Neculai, Dante; Juhasz, Szilvia; Morocz, Monika; Gali, Himabindu; Dhe-Paganon, Sirano; Venclovas, Česlovas; Haracska, Lajos

    2015-09-08

    Defects in the ability to respond properly to an unrepaired DNA lesion blocking replication promote genomic instability and cancer. Human HLTF, implicated in error-free replication of damaged DNA and tumour suppression, exhibits a HIRAN domain, a RING domain, and a SWI/SNF domain facilitating DNA-binding, PCNA-polyubiquitin-ligase, and dsDNA-translocase activities, respectively. Here, we investigate the mechanism of HLTF action with emphasis on its HIRAN domain. We found that in cells HLTF promotes the filling-in of gaps left opposite damaged DNA during replication, and this postreplication repair function depends on its HIRAN domain. Our biochemical assays show that HIRAN domain mutant HLTF proteins retain their ubiquitin ligase, ATPase and dsDNA translocase activities but are impaired in binding to a model replication fork. These data and our structural study indicate that the HIRAN domain recruits HLTF to a stalled replication fork, and it also provides the direction for the movement of the dsDNA translocase motor domain for fork reversal. We suggest functional similarities between the HIRAN, the OB, the HARP2, and other domains found in certain motor proteins, which may explain why only a subset of DNA translocases can carry out fork reversal.

  15. Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Achar, Yathish Jagadheesh; Balogh, David; Neculai, Dante; Juhasz, Szilvia; Morocz, Monika; Gali, Himabindu; Dhe-Paganon, Sirano; Venclovas, Česlovas; Haracska, Lajos

    2015-09-08

    Defects in the ability to respond properly to an unrepaired DNA lesion blocking replication promote genomic instability and cancer. Human HLTF, implicated in error-free replication of damaged DNA and tumour suppression, exhibits a HIRAN domain, a RING domain, and a SWI/SNF domain facilitating DNA-binding, PCNA-polyubiquitin-ligase, and dsDNA-translocase activities, respectively. Here, we investigate the mechanism of HLTF action with emphasis on its HIRAN domain. We found that in cells HLTF promotes the filling-in of gaps left opposite damaged DNA during replication, and this postreplication repair function depends on its HIRAN domain. Our biochemical assays show that HIRAN domain mutant HLTF proteinsmore » retain their ubiquitin ligase, ATPase and dsDNA translocase activities but are impaired in binding to a model replication fork. These data and our structural study indicate that the HIRAN domain recruits HLTF to a stalled replication fork, and it also provides the direction for the movement of the dsDNA translocase motor domain for fork reversal. We suggest functional similarities between the HIRAN, the OB, the HARP2, and other domains found in certain motor proteins, which may explain why only a subset of DNA translocases can carry out fork reversal.« less

  16. Slow Dynamics of Orbital Domains in Manganite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Slow Dynamics of Orbital Domains in Manganite Print At the ALS, an international team of researchers has used low-energy coherent x rays to extract new knowledge about the...

  17. Slow Dynamics of Orbital Domains in Manganite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    technique with photons of light that have wavelengths a billion times smaller than radio waves in order to study their domain motion. By using these soft x rays generated at...

  18. Slow Dynamics of Orbital Domains in Manganite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Slow Dynamics of Orbital Domains in Manganite Slow Dynamics of Orbital Domains in Manganite Print Wednesday, 25 June 2008 00:00 At the ALS, an international team of researchers has used low-energy coherent x rays to extract new knowledge about the correlated motion of groups of self-assembled, outer-lying electrons in the extremely complex electronic system found in manganites. The manganite family of materials has puzzled physicists for years by defying standard models for the motion of

  19. Sapphire decomposition and inversion domains in N-polar aluminum nitride

    SciTech Connect (OSTI)

    Hussey, Lindsay White, Ryan M.; Kirste, Ronny; Bryan, Isaac; Guo, Wei; Osterman, Katherine; Haidet, Brian; Bryan, Zachary; Bobea, Milena; Collazo, Ramn; Sitar, Zlatko; Mita, Seiji

    2014-01-20

    Transmission electron microscopy (TEM) techniques and potassium hydroxide (KOH) etching confirmed that inversion domains in the N-polar AlN grown on c-plane sapphire were due to the decomposition of sapphire in the presence of hydrogen. The inversion domains were found to correspond to voids at the AlN and sapphire interface, and transmission electron microscopy results showed a V-shaped, columnar inversion domain with staggered domain boundary sidewalls. Voids were also observed in the simultaneously grown Al-polar AlN, however no inversion domains were present. The polarity of AlN grown above the decomposed regions of the sapphire substrate was confirmed to be Al-polar by KOH etching and TEM.

  20. Structure of a Longitudinal Actin Dimer Assembled by Tandem W Domains: Implications for Actin Filament Nucleation

    SciTech Connect (OSTI)

    Rebowski, Grzegorz; Namgoong, Suk; Boczkowska, Malgorzata; Leavis, Paul C.; Navaza, Jorge; Dominguez, Roberto

    2013-11-20

    Actin filament nucleators initiate polymerization in cells in a regulated manner. A common architecture among these molecules consists of tandem WASP homology 2 domains (W domains) that recruit three to four actin subunits to form a polymerization nucleus. We describe a low-resolution crystal structure of an actin dimer assembled by tandem W domains, where the first W domain is cross-linked to Cys374 of the actin subunit bound to it, whereas the last W domain is followed by the C-terminal pointed end-capping helix of thymosin {beta}4. While the arrangement of actin subunits in the dimer resembles that of a long-pitch helix of the actin filament, important differences are observed. These differences result from steric hindrance of the W domain with intersubunit contacts in the actin filament. We also determined the structure of the first W domain of Vibrio parahaemolyticus VopL cross-linked to actin Cys374 and show it to be nearly identical with non-cross-linked W-Actin structures. This result validates the use of cross-linking as a tool for the study of actin nucleation complexes, whose natural tendency to polymerize interferes with most structural methods. Combined with a biochemical analysis of nucleation, the structures may explain why nucleators based on tandem W domains with short inter-W linkers have relatively weak activity, cannot stay bound to filaments after nucleation, and are unlikely to influence filament elongation. The findings may also explain why nucleation-promoting factors of the Arp2/3 complex, which are related to tandem-W-domain nucleators, are ejected from branch junctions after nucleation. We finally show that the simple addition of the C-terminal pointed end-capping helix of thymosin {beta}4 to tandem W domains can change their activity from actin filament nucleation to monomer sequestration.

  1. NREL: Wind Research - Wind Career Map Shows Wind Industry Career...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Wind Career Map Shows Wind Industry Career Opportunities, Paths A screenshot of the wind career map showing the various points on a chart that show different careers in the wind...

  2. Secretary Chu Tours the 2013 Washington Auto Show | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Tours the 2013 Washington Auto Show Secretary Chu Tours the 2013 Washington Auto Show January 31, 2013 - 5:04pm Addthis 1 of 10 While at the Washington Auto Show, Energy Secretary ...

  3. Human-computer interface incorporating personal and application domains

    DOE Patents [OSTI]

    Anderson, Thomas G.

    2004-04-20

    The present invention provides a human-computer interface. The interface includes provision of an application domain, for example corresponding to a three-dimensional application. The user is allowed to navigate and interact with the application domain. The interface also includes a personal domain, offering the user controls and interaction distinct from the application domain. The separation into two domains allows the most suitable interface methods in each: for example, three-dimensional navigation in the application domain, and two- or three-dimensional controls in the personal domain. Transitions between the application domain and the personal domain are under control of the user, and the transition method is substantially independent of the navigation in the application domain. For example, the user can fly through a three-dimensional application domain, and always move to the personal domain by moving a cursor near one extreme of the display.

  4. Human-computer interface incorporating personal and application domains

    DOE Patents [OSTI]

    Anderson, Thomas G.

    2011-03-29

    The present invention provides a human-computer interface. The interface includes provision of an application domain, for example corresponding to a three-dimensional application. The user is allowed to navigate and interact with the application domain. The interface also includes a personal domain, offering the user controls and interaction distinct from the application domain. The separation into two domains allows the most suitable interface methods in each: for example, three-dimensional navigation in the application domain, and two- or three-dimensional controls in the personal domain. Transitions between the application domain and the personal domain are under control of the user, and the transition method is substantially independent of the navigation in the application domain. For example, the user can fly through a three-dimensional application domain, and always move to the personal domain by moving a cursor near one extreme of the display.

  5. Shanghai Hi Show Photovoltaic Science Technology Co Ltd | Open...

    Open Energy Info (EERE)

    Hi Show Photovoltaic Science Technology Co Ltd Jump to: navigation, search Name: Shanghai Hi-Show Photovoltaic Science & Technology Co., Ltd Place: Shanghai Municipality, China...

  6. Federal Energy Management Trade Show | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Federal Energy Management Trade Show Federal Energy Management Trade Show Addthis 1 of 4 Timothy Unruh, Program Manager for the Office of Energy Efficiency and Renewable Energy...

  7. NREL Refinery Process Shows Increased Effectiveness of Producing...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Refinery Process Shows Increased Effectiveness of Producing Ethanol from Algae NREL Refinery Process Shows Increased Effectiveness of Producing Ethanol from Algae February 11, 2016 ...

  8. Water telescope's first sky map shows flickering black holes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Water telescope's first sky map shows flickering black holes Water telescope's first sky map shows flickering black holes The High Altitude Water Cherenkov observatory has released ...

  9. Smart Surface and Lubrication Engineering show Promise for Gearbox...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Smart Surface and Lubrication Engineering show Promise for Gearbox Reliability Smart Surface and Lubrication Engineering show Promise for Gearbox Reliability May 20, 2011 - 1:10pm ...

  10. Energy Innovation Hub Report Shows Philadelphia-area Building...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Innovation Hub Report Shows Philadelphia-area Building Retrofits Could Support 23,500 Jobs Energy Innovation Hub Report Shows Philadelphia-area Building Retrofits Could Support ...

  11. Dual-domain point diffraction interferometer

    DOE Patents [OSTI]

    Naulleau, Patrick P.; Goldberg, Kenneth Alan

    2000-01-01

    A hybrid spatial/temporal-domain point diffraction interferometer (referred to as the dual-domain PS/PDI) that is capable of suppressing the scattered-reference-light noise that hinders the conventional PS/PDI is provided. The dual-domain PS/PDI combines the separate noise-suppression capabilities of the widely-used phase-shifting and Fourier-transform fringe pattern analysis methods. The dual-domain PS/PDI relies on both a more restrictive implementation of the image plane PS/PDI mask and a new analysis method to be applied to the interferograms generated and recorded by the modified PS/PDI. The more restrictive PS/PDI mask guarantees the elimination of spatial-frequency crosstalk between the signal and the scattered-light noise arising from scattered-reference-light interfering with the test beam. The new dual-domain analysis method is then used to eliminate scattered-light noise arising from both the scattered-reference-light interfering with the test beam and the scattered-reference-light interfering with the "true" pinhole-diffracted reference light. The dual-domain analysis method has also been demonstrated to provide performance enhancement when using the non-optimized standard PS/PDI design. The dual-domain PS/PDI is essentially a three-tiered filtering system composed of lowpass spatial-filtering the test-beam electric field using the more restrictive PS/PDI mask, bandpass spatial-filtering the individual interferogram irradiance frames making up the phase-shifting series, and bandpass temporal-filtering the phase-shifting series as a whole.

  12. Category:Controlled Source Frequency-Domain Magnetics | Open...

    Open Energy Info (EERE)

    Controlled Source Frequency-Domain Magnetics Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Geothermalpower.jpg Looking for the Controlled Source Frequency-Domain...

  13. On the predictability of the orientation of protein domains joined...

    Office of Scientific and Technical Information (OSTI)

    of protein domains joined by a spanning alpha-helical linker Citation Details In-Document Search Title: On the predictability of the orientation of protein domains ...

  14. Molecular functions of the TLE tetramerization domain in Wnt...

    Office of Scientific and Technical Information (OSTI)

    Molecular functions of the TLE tetramerization domain in Wnt target gene repression Citation Details In-Document Search Title: Molecular functions of the TLE tetramerization domain ...

  15. Time-Domain Electromagnetics At Soda Lake Area (Combs 2006) ...

    Open Energy Info (EERE)

    Time-Domain Electromagnetics At Soda Lake Area (Combs 2006) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Soda...

  16. Category:Time-Domain Electromagnetics | Open Energy Information

    Open Energy Info (EERE)

    Time-Domain Electromagnetics Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Geothermalpower.jpg Looking for the Time-Domain Electromagnetics page? For detailed...

  17. Jamming Behavior of Domains in a Spiral Antiferromagnetic System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Jamming Behavior of Domains in a Spiral Antiferromagnetic System Jamming Behavior of Domains in a Spiral Antiferromagnetic System Print Tuesday, 04 June 2013 13:34 This schematic...

  18. Ferroelasticity and domain physics in two-dimensional transition...

    Office of Scientific and Technical Information (OSTI)

    Accepted Manuscript: Ferroelasticity and domain physics in two-dimensional transition metal dichalcogenide monolayers Prev Next Title: Ferroelasticity and domain physics in ...

  19. Statistical and Domain Analytics Applied to PV Module Lifetime...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Statistical and Domain Analytics Applied to PV Module Lifetime and Degradation Science Statistical and Domain Analytics Applied to PV Module Lifetime and Degradation Science ...

  20. Effects of twin boundary mobility on domain microstructure evolution in magnetic shape memory alloys: Phase field simulation

    SciTech Connect (OSTI)

    Jin, Yongmei M.

    2009-02-09

    Effects of twin boundary mobility on domain microstructure evolution during magnetic field-induced deformation in magnetic shape memory alloys are studied by phase field micromagnetic microelastic modeling. The simulations show that different twin boundary mobilities lead to drastically different domain microstructures and evolution pathways, yielding very different magnetization and strain responses, even with opposite signs. The study also reveals complex domain phenomena in magnetic shape memory alloys.

  1. New Geothermal Prospects in the Western United States Show Promise...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Geothermal Prospects in the Western United States Show Promise New Geothermal Prospects in the Western United States Show Promise February 27, 2013 - 2:21pm Addthis New geothermal ...

  2. ANL Study Shows Wind Power Decreases Power Sector Emissions ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ANL Study Shows Wind Power Decreases Power Sector Emissions ANL Study Shows Wind Power Decreases Power Sector Emissions May 1, 2012 - 3:38pm Addthis This is an excerpt from the ...

  3. Molecular functions of the TLE tetramerization domain in Wnt target gene

    Office of Scientific and Technical Information (OSTI)

    repression (Journal Article) | SciTech Connect Molecular functions of the TLE tetramerization domain in Wnt target gene repression Citation Details In-Document Search Title: Molecular functions of the TLE tetramerization domain in Wnt target gene repression Authors: Chodaparambil, Jayanth V. ; Pate, Kira T. ; Hepler, Margretta R.D. ; Tsai, Becky P. ; Muthurajan, Uma M. ; Luger, Karolin ; Waterman, Marian L. ; Weis, William I. [1] ; CSU) [2] ; UCI) [2] + Show Author Affiliations (Stanford) (

  4. Structure of the N-terminal dimerization domain of CEACAM7 (Journal

    Office of Scientific and Technical Information (OSTI)

    Article) | SciTech Connect SciTech Connect Search Results Journal Article: Structure of the N-terminal dimerization domain of CEACAM7 Citation Details In-Document Search Title: Structure of the N-terminal dimerization domain of CEACAM7 Authors: Bonsor, Daniel A. ; Beckett, Dorothy ; Sundberg, Eric J. [1] ; Maryland) [2] + Show Author Affiliations (Maryland-MED) ( Publication Date: 2015-10-02 OSTI Identifier: 1214040 Resource Type: Journal Article Resource Relation: Journal Name: Acta

  5. Crystal structure of the Nod1 caspase activation and recruitment domain

    Office of Scientific and Technical Information (OSTI)

    (Journal Article) | SciTech Connect Crystal structure of the Nod1 caspase activation and recruitment domain Citation Details In-Document Search Title: Crystal structure of the Nod1 caspase activation and recruitment domain Authors: Coussens, N.P. ; Mowers, J.C. ; McDonald, C. ; Nunez, G. ; Ramaswamy, S. [1] ; LRI) [2] ; Michigan-Med) [2] + Show Author Affiliations (Iowa) ( Publication Date: 2015-09-02 OSTI Identifier: 1213704 Resource Type: Journal Article Resource Relation: Journal Name:

  6. Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional

    Office of Scientific and Technical Information (OSTI)

    Activity (Journal Article) | SciTech Connect Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity Citation Details In-Document Search Title: Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity Authors: Hu, Tiancen ; Yeh, Jennifer E. ; Pinello, Luca ; Jacob, Jaison ; Chakravarthy, Srinivas ; Yuan, Guo-Cheng ; Chopra, Rajiv ; Frank, David A. [1] ; DFCI) [2] ; Harvard) [2] ; IIT) [2] ; BWH) [2] + Show Author Affiliations

  7. Crystal structure of a ;#8203;BRAF kinase domain monomer explains basis for

    Office of Scientific and Technical Information (OSTI)

    allosteric regulation (Journal Article) | SciTech Connect Crystal structure of a ;#8203;BRAF kinase domain monomer explains basis for allosteric regulation Citation Details In-Document Search Title: Crystal structure of a ;#8203;BRAF kinase domain monomer explains basis for allosteric regulation Authors: Thevakumaran, Neroshan ; Lavoie, Hugo ; Critton, David A. ; Tebben, Andrew ; Marinier, Anne ; Sicheri, Frank ; Therrien , Marc [1] ; Montreal) [2] ; BMS) [2] + Show Author Affiliations

  8. Standing gravitational waves from domain walls

    SciTech Connect (OSTI)

    Gogberashvili, Merab; Myrzakul, Shynaray; Singleton, Douglas

    2009-07-15

    We construct a plane symmetric, standing gravitational wave for a domain wall plus a massless scalar field. The scalar field can be associated with a fluid which has the properties of 'stiff' matter, i.e., matter in which the speed of sound equals the speed of light. Although domain walls are observationally ruled out in the present era, the solution has interesting features which might shed light on the character of exact nonlinear wave solutions to Einstein's equations. Additionally this solution may act as a template for higher dimensional 'brane-world' model standing waves.

  9. Getting the Most Out of a Show | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Publications, Exhibits, & Logos » Getting the Most Out of a Show Getting the Most Out of a Show These guidelines are designed to assist you during the event, in order to get the most out of the showing of your exhibit. Look the Part Create a good impression for EERE by looking polished and professional. Wear business-like, comfortable attire. Don't forget your nametag! Get plenty of rest before the show, and pace yourself during the show (you will need breaks, so schedule them). Staffing

  10. The RCK Domain of the KtrAB K+ Transporter: Multiple Conformations of an Octameric Ring

    SciTech Connect (OSTI)

    Albright,R.; Vazquez Ibar, J.; Kim, C.; Gruner, S.; Morais-Cabral, J.

    2006-01-01

    The KtrAB ion transporter is a complex of the KtrB membrane protein and KtrA, an RCK domain. RCK domains regulate eukaryotic and prokaryotic membrane proteins involved in K{sup +} transport. Conflicting functional models have proposed two different oligomeric arrangements for RCK domains, tetramer versus octamer. Our results for the KtrAB RCK domain clearly show an octamer in solution and in the crystal. We determined the structure of this protein in three different octameric ring conformations that resemble the RCK-domain octamer observed in the MthK potassium channel but show striking differences in size and symmetry. We present experimental evidence for the association between one RCK octameric ring and two KtrB membrane proteins. These results provide insights into the quaternary organization of the KtrAB transporter and its mechanism of activation and show that the RCK-domain octameric ring model is generally applicable to other ion-transport systems.

  11. Nucleic acids encoding a cellulose binding domain

    DOE Patents [OSTI]

    Shoseyov, O.; Shpiegl, I.; Goldstein, M.A.; Doi, R.H.

    1996-03-05

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques. 15 figs.

  12. Nucleic acids encoding a cellulose binding domain

    DOE Patents [OSTI]

    Shoseyov, Oded; Shpiegl, Itai; Goldstein, Marc A.; Doi, Roy H.

    1996-01-01

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.

  13. Water telescope's first sky map shows flickering black holes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Water telescope's first sky map shows flickering black holes Water telescope's first sky map shows flickering black holes The High Altitude Water Cherenkov observatory has released its first map of the sky, including the first measurements of how often black holes flicker on and off. It has also caught pulsars, supernova remnants, and other bizarre cosmic beasts. April 24, 2016 Water telescope's first sky map shows flickering black holes Three new sources of gamma rays spotted by HAWC. Credit:

  14. CHICAGO HOUSE PARTIES SHOW WAYS TO UPGRADE | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    CHICAGO HOUSE PARTIES SHOW WAYS TO UPGRADE CHICAGO HOUSE PARTIES SHOW WAYS TO UPGRADE CHICAGO HOUSE PARTIES SHOW WAYS TO UPGRADE The Chicago Metropolitan Agency for Planning (CMAP) and its partners created Energy Impact Illinois (EI2) to promote home energy upgrades in single-family homes, multifamily housing units, and commercial buildings to help the region meet its 2008 Chicago Climate Action Plan and longer term GO TO 2040 Strategic Plan. EI2 enlisted the help of the Elevate Energy, a

  15. 3D Printed Car at the International Manufacturing Technology Show |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 3D Printed Car at the International Manufacturing Technology Show 3D Printed Car at the International Manufacturing Technology Show Addthis WORLD'S FIRST 1 of 6 WORLD'S FIRST The world's first 3D-printed car on display at the International Manufacturing Technology Show in Chicago last week. Arizona-based Local Motors, and Cincinnati Incorporated teamed with Oak Ridge National Laboratory's Manufacturing Demonstration Facility-with funding support from the Energy

  16. The Majorana Demonstrator: Progress towards showing the feasibility...

    Office of Scientific and Technical Information (OSTI)

    Authors: Finnerty, P. 1 ; Elliott, Steven R. 2 ; Boswell, Melissa 2 ; Kidd, Mary 2 ; Rielage, Keith R. 2 ; Ronquest, Michael 2 ; Steele, Steven 2 + Show Author ...

  17. New Report Shows Trend Toward Larger Offshore Wind Systems, with...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Report Shows Trend Toward Larger Offshore Wind Systems, with 11 Advanced Stage Projects ... in offshore wind farms, increasing the amount of electricity delivered to consumers. ...

  18. NREL: Technology Transfer - New Video Shows How NREL Is Redefining...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Video Shows How NREL Is Redefining What's Possible for Renewable Energy Through Grid Integration January 23, 2015 NREL is spearheading engineering innovations that will help...

  19. NREL: Wind Research - New Video Shows How NREL Is Redefining...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Video Shows How NREL Is Redefining What's Possible for Renewable Energy Through Grid Integration January 23, 2015 NREL is spearheading engineering innovations that will help...

  20. Latest Report Shows Cost of Going Solar has Dropped Significantly...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The report shows that the installed price of distributed solar photovoltaic (PV) power ... for residential and non-residential photovoltaic (PV) systems installed in the United ...

  1. Study Shows Active Power Controls from Wind May Increase Revenues...

    Office of Environmental Management (EM)

    Revenues and Improve System Reliability Study Shows Active Power Controls from Wind May Increase Revenues and Improve System Reliability January 6, 2014 - 10:00am Addthis ...

  2. Analysis shows greenhouse gas emissions similar for shale, crude...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Michael Wang, Argonne senior scientist and lead on the GREET model Analysis shows greenhouse gas emissions similar for shale, crude oil By Tona Kunz * October 15, 2015 Tweet ...

  3. Sandia Energy - Biofuels Blend Right In: Researchers Show Ionic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biofuels Blend Right In: Researchers Show Ionic Liquids Effective for Pretreating Mixed Blends of Biofuel Feedstocks Home Renewable Energy Energy Transportation Energy Biofuels...

  4. Argonne Site Map Showing CNM Location | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Argonne Site Map Showing CNM Location Find your way to the Center for Nanoscale Materials on the Argonne National Laboratory campus. PDF icon CNM-Argonne_map

  5. Widget:ShowRefFieldsButton | Open Energy Information

    Open Energy Info (EERE)

    widget provides supporting functionality to forms that want to capture references for specific values. Specifically, this widget creates the Show Reference Fields button, which...

  6. Magnetism reflectometer study shows LiF layers improve efficiency...

    Office of Scientific and Technical Information (OSTI)

    Magnetism reflectometer study shows LiF layers improve efficiency in spin valve devices ... when an organic polymer semiconductor layer is placed between the magnetic materials. ...

  7. SLIDESHOW: Secretary Moniz Tours 2014 Washington Auto Show

    Broader source: Energy.gov [DOE]

    A slideshow featuring highlights from Secretary Moniz's tour of the 2014 Washington Auto Show is currently posted on the Energy Department's blog.

  8. User:Nlangle/show map test | Open Energy Information

    Open Energy Info (EERE)

    show map test < User:Nlangle Jump to: navigation, search Loading map... "minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":"ROADMAP","SATELLITE","H...

  9. DOE Booth Presentations From Grainger Show 2015 Downloads

    Broader source: Energy.gov [DOE]

    DOE hosted its solid-state lighting informational booth February 16–18 at the annual Grainger Show in Orlando, FL. With over 17,000 attendees and over 750 exhibitors, the show gathered a wide range of Grainger customers—from universities to large hotel chains as well as Grainger team members to learn the latest about LED lighting.

  10. The Chemistry Magic Show Captivates Kids | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chemistry Magic Show Captivates Kids Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Tumblr (Opens in new window) The Chemistry Magic Show Captivates Kids Vin Smentkowski 2012.11.16 My colleague, Christopher (Chris) Dosch, also known as Ignito the Magician, shared a recap on the Global Research Chemistry Magic Show that took place last week during

  11. New Report Shows Trend Toward Larger Offshore Wind Systems

    Broader source: Energy.gov [DOE]

    The Energy Department released a new report showing progress for the U.S. offshore wind energy market in 2012, including 11 commercial-scale U.S. projects reaching an advanced stage of development.

  12. New Geothermal Prospects in the Western United States Show Promise

    Broader source: Energy.gov [DOE]

    New geothermal prospects in the western United States show promise, according to the new 2013 Annual U.S. Geothermal Power Production and Development Report, published by the Geothermal Energy Association this week.

  13. Secretary Chu Speaks at the 2010 Washington Auto Show

    Broader source: Energy.gov [DOE]

    at the 2010 Washington Auto Show, Secretary Chu lays out a roadmap for how the U.S. can lead the world in making the clean vehicles we need. He also announced that the Department of Energy had...

  14. Considering removing "Show Preview" button on utility rate form...

    Open Energy Info (EERE)

    Rates I'm considering removing the "Show Preview" button, since it does not work (javascript validation issue that could be fixed), and it doesn't make sense. The reason to...

  15. JSON shows incomplete info | OpenEI Community

    Open Energy Info (EERE)

    found several rates where the JSON file doesn't show all of the information shown in the web interface. This is not an approval issue since I see it on both rates that say "This...

  16. Global Climate Change Assessment Report Shows Nations Not Doing...

    Open Energy Info (EERE)

    Global Climate Change Assessment Report Shows Nations Not Doing Enough Home > Blogs > Dc's blog Dc's picture Submitted by Dc(266) Contributor 5 November, 2014 - 14:49 The latest...

  17. U.S. gasoline prices show little movement (long version)

    U.S. Energy Information Administration (EIA) Indexed Site

    30, 2014 U.S. gasoline prices show little movement (long version) The U.S. average retail ... Pump prices were highest in the West Coast states at 4.04 a gallon, up 2 cents from a ...

  18. New Report Shows Domestic Offshore Wind Industry Potential, 21...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Report Shows Domestic Offshore Wind Industry Potential, 21 Projects Planned in U.S. Waters ... first commercial-scale offshore wind farm, one of 21 projects totaling 15,650 ...

  19. 2014 Data Book Shows Increased Use of Renewable Electricity ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Book shows that U.S. renewable electricity grew to 15.5 percent of total installed capacity and 13.5 percent of total electricity generation. Published annually by the National...

  20. Washington Auto Show Spotlight: How Fuel Cell Electric Vehicles Work |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Washington Auto Show Spotlight: How Fuel Cell Electric Vehicles Work Washington Auto Show Spotlight: How Fuel Cell Electric Vehicles Work January 27, 2015 - 12:57pm Addthis The Hyundai Tucson FCEV is currently available for lease in Southern California for less than $500 per month, including free hydrogen fuel. Hydrogen for FCEVs can be produced from a variety of resources all providing emission reductions. Hydrogen derived from natural gas reduces emissions by half and

  1. NREL Refinery Process Shows Increased Effectiveness of Producing Ethanol

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    from Algae | Department of Energy Refinery Process Shows Increased Effectiveness of Producing Ethanol from Algae NREL Refinery Process Shows Increased Effectiveness of Producing Ethanol from Algae February 11, 2016 - 5:07pm Addthis A new biorefinery process developed by scientists at the Energy Department's National Renewable Energy Laboratory (NREL) with funding from the U.S. Department of Energy's Bioenergy Technologies Office (BETO) has proven to be significantly more effective at

  2. Award Fee Determination Shows Performance Improvement in WTP Contractor |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Award Fee Determination Shows Performance Improvement in WTP Contractor Award Fee Determination Shows Performance Improvement in WTP Contractor April 14, 2016 - 1:15pm Addthis RICHLAND, Wash. - EM Office of River Protection (ORP) Waste Treatment and Immobilization Plant (WTP) contractor Bechtel National Inc. improved its performance slightly in calendar year 2015 compared to the last half of 2014, earning 66 percent of its possible award fee, or $8.31 million out of a

  3. The Majorana Demonstrator: Progress towards showing the feasibility of a

    Office of Scientific and Technical Information (OSTI)

    76Ge neutrinoless double-beta decay experiment (Conference) | SciTech Connect The Majorana Demonstrator: Progress towards showing the feasibility of a 76Ge neutrinoless double-beta decay experiment Citation Details In-Document Search Title: The Majorana Demonstrator: Progress towards showing the feasibility of a 76Ge neutrinoless double-beta decay experiment × You are accessing a document from the Department of Energy's (DOE) SciTech Connect. This site is a product of DOE's Office of

  4. DOE Releases New Analysis Showing Significant Advances in Electric Vehicle

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Deployment | Department of Energy Analysis Showing Significant Advances in Electric Vehicle Deployment DOE Releases New Analysis Showing Significant Advances in Electric Vehicle Deployment February 8, 2011 - 12:00am Addthis WASHINGTON - The U.S. Department of Energy today released One Million Electric Vehicles by 2015 (pdf - 220 kb), an analysis of advances in electric vehicle deployment and progress to date in meeting President Obama's goal of putting one million electric vehicles on the

  5. DOE Releases Report Showing Tremendous Energy Efficiency Opportunity in

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Commercial Tenant Spaces | Department of Energy Releases Report Showing Tremendous Energy Efficiency Opportunity in Commercial Tenant Spaces DOE Releases Report Showing Tremendous Energy Efficiency Opportunity in Commercial Tenant Spaces May 3, 2016 - 4:56pm Addthis bto_tenant_spaces_report_042816.jpg WASHINGTON, D.C. - The U.S. Department of Energy (DOE) published its Energy Efficiency in Commercial Tenant Spaces feasibility study that highlights both opportunities and barriers to

  6. NREL: Hydrogen and Fuel Cells Research - Evaluation Results Show Continued

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Improvements in Fuel Cell Electric Vehicle Durability, Fuel Economy, Driving Range Evaluation Results Show Continued Improvements in Fuel Cell Electric Vehicle Durability, Fuel Economy, Driving Range Project Technology Validation: Fuel Cell Electric Vehicle Evaluation Contact Jennifer Kurtz Related Publications FCEV Composite Data Products New composite data products (CDPs) published by NREL's National Fuel Cell Technology Evaluation Center (NFCTEC) show that fuel cell durability has

  7. New global HIV vaccine design shows promise in monkeys

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New global HIV vaccine design shows promise in monkeys New global HIV vaccine design shows promise in monkeys These vaccines are specifically designed to present the most common forms of parts of the virus that can be recognized by the immune system. October 30, 2013 Bette Korber of Los Alamos National Laboratory, who developed a component of a new vaccine against HIV, now being tested in monkeys. Bette Korber of Los Alamos National Laboratory, who developed a component of a new vaccine against

  8. Moniz: Tesla Repayment Shows the Strength of Energy Department's Overall

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Loan Portfolio | Department of Energy Moniz: Tesla Repayment Shows the Strength of Energy Department's Overall Loan Portfolio Moniz: Tesla Repayment Shows the Strength of Energy Department's Overall Loan Portfolio May 22, 2013 - 4:24pm Addthis News Media Contact (202) 586-4940 WASHINGTON -- Today, Tesla Motors repaid the entire remaining balance on a $465 million loan from the Department of Energy nine years earlier than originally required. U.S. Energy Secretary Ernest Moniz made the

  9. Plasma research shows promise for future compact accelerators

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Plasma research shows promise for future compact accelerators Plasma research shows promise for future compact accelerators A transformative breakthrough in controlling ion beams allows small-scale laser-plasma accelerators to deliver unprecedented power densities. December 21, 2015 The team in front of the Trident Target Chamber. Back, from left: Tom Shimada, Sha-Marie Reid, Adam Sefkow, Miguel Santiago, and Chris Hamilton. Front, from left: Russ Mortensen, Chengkun Huang, Sasi Palaniyappan,

  10. The Majorana Demonstrator: Progress towards showing the feasibility of a

    Office of Scientific and Technical Information (OSTI)

    76Ge neutrinoless double-beta decay experiment (Conference) | SciTech Connect The Majorana Demonstrator: Progress towards showing the feasibility of a 76Ge neutrinoless double-beta decay experiment Citation Details In-Document Search Title: The Majorana Demonstrator: Progress towards showing the feasibility of a 76Ge neutrinoless double-beta decay experiment Authors: Finnerty, P. [1] ; Elliott, Steven R. [2] ; Boswell, Melissa [2] ; Kidd, Mary [2] ; Rielage, Keith R. [2] ; Ronquest, Michael

  11. LHC RF System Time-Domain Simulation

    SciTech Connect (OSTI)

    Mastorides, T.; Rivetta, C.

    2010-09-14

    Non-linear time-domain simulations have been developed for the Positron-Electron Project (PEP-II) and the Large Hadron Collider (LHC). These simulations capture the dynamic behavior of the RF station-beam interaction and are structured to reproduce the technical characteristics of the system (noise contributions, non-linear elements, and more). As such, they provide useful results and insight for the development and design of future LLRF feedback systems. They are also a valuable tool for the study of diverse longitudinal beam dynamics effects such as coupled-bunch impedance driven instabilities and single bunch longitudinal emittance growth. Results from these studies and related measurements from PEP-II and LHC have been presented in multiple places. This report presents an example of the time-domain simulation implementation for the LHC.

  12. Domain decomposition multigrid for unstructured grids

    SciTech Connect (OSTI)

    Shapira, Yair

    1997-01-01

    A two-level preconditioning method for the solution of elliptic boundary value problems using finite element schemes on possibly unstructured meshes is introduced. It is based on a domain decomposition and a Galerkin scheme for the coarse level vertex unknowns. For both the implementation and the analysis, it is not required that the curves of discontinuity in the coefficients of the PDE match the interfaces between subdomains. Generalizations to nonmatching or overlapping grids are made.

  13. Slow Dynamics of Orbital Domains in Manganite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Slow Dynamics of Orbital Domains in Manganite Print At the ALS, an international team of researchers has used low-energy coherent x rays to extract new knowledge about the correlated motion of groups of self-assembled, outer-lying electrons in the extremely complex electronic system found in manganites. The manganite family of materials has puzzled physicists for years by defying standard models for the motion of electrons in crystals. By controlling the properties of the incident x rays, the

  14. Slow Dynamics of Orbital Domains in Manganite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Slow Dynamics of Orbital Domains in Manganite Print At the ALS, an international team of researchers has used low-energy coherent x rays to extract new knowledge about the correlated motion of groups of self-assembled, outer-lying electrons in the extremely complex electronic system found in manganites. The manganite family of materials has puzzled physicists for years by defying standard models for the motion of electrons in crystals. By controlling the properties of the incident x rays, the

  15. Slow Dynamics of Orbital Domains in Manganite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Slow Dynamics of Orbital Domains in Manganite Print At the ALS, an international team of researchers has used low-energy coherent x rays to extract new knowledge about the correlated motion of groups of self-assembled, outer-lying electrons in the extremely complex electronic system found in manganites. The manganite family of materials has puzzled physicists for years by defying standard models for the motion of electrons in crystals. By controlling the properties of the incident x rays, the

  16. Slow Dynamics of Orbital Domains in Manganite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Slow Dynamics of Orbital Domains in Manganite Print At the ALS, an international team of researchers has used low-energy coherent x rays to extract new knowledge about the correlated motion of groups of self-assembled, outer-lying electrons in the extremely complex electronic system found in manganites. The manganite family of materials has puzzled physicists for years by defying standard models for the motion of electrons in crystals. By controlling the properties of the incident x rays, the

  17. Slow Dynamics of Orbital Domains in Manganite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Slow Dynamics of Orbital Domains in Manganite Print At the ALS, an international team of researchers has used low-energy coherent x rays to extract new knowledge about the correlated motion of groups of self-assembled, outer-lying electrons in the extremely complex electronic system found in manganites. The manganite family of materials has puzzled physicists for years by defying standard models for the motion of electrons in crystals. By controlling the properties of the incident x rays, the

  18. High Performance House Showcased at Builders Show - News Releases | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High Performance House Showcased at Builders Show January 20, 2004 Golden, Colo. - Homebuilders attending the 2004 International Builders' Show in Las Vegas can tour a new kind of home-a highly energy-efficient Zero Energy Home that will produce as much electricity as it uses over the course of a year. The U.S. Department of Energy (DOE) and its National Renewable Energy Laboratory (NREL) partnered with Pardee Homes and energy consultant ConSol to introduce the Zero Energy Home concept with this

  19. 2014 Washington Auto Show Slideshow | Department of Energy

    Energy Savers [EERE]

    4 Washington Auto Show Slideshow 2014 Washington Auto Show Slideshow Addthis Hyundai Fuel Cell 1 of 14 Hyundai Fuel Cell Pictured here is Secretary Moniz looking at the fuel cell and motor used to power Hyundai's Tucson fuel cell vehicle. Fuel cell vehicles use hydrogen to produce electricity, which powers an electric motor to make the vehicle and its accessories work. Image: Sarah Gerrity, Energy Department. Date taken: 2014-01-22 11:14 Under the hood of the Hyundai Tucson Fuel Cell Vehicle 2

  20. EM Makes Strong Showing in Federal Food Drive

    Broader source: Energy.gov [DOE]

    WASHINGTON, D.C. – EM made a strong showing in this year’s Feds Feed Families drive, contributing 46,493 pounds of food across the DOE complex and topping it off by winning top prize in a government-wide chili cookoff held at the Department’s headquarters.

  1. Regional Partnership Documentary Wins "Best of Show" Aurora Award

    Broader source: Energy.gov [DOE]

    A documentary co-produced by Prairie Public Broadcasting and the Plains CO2 Reduction (PCOR) Partnership with support from the U.S. Department of Energy has received a 2012 Platinum Best of Show Aurora Award—the highest honor awarded—in the nature/environment documentary category.

  2. Wyo. Stat. 1-26 - Eminent Domain | Open Energy Information

    Open Energy Info (EERE)

    Wyo. Stat. 1-26 - Eminent Domain Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: Wyo. Stat. 1-26 - Eminent DomainLegal...

  3. Web Sites Show Petroleum Reduction Options - News Releases | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Web Sites Show Petroleum Reduction Options October 25, 2007 Handy new tools on the U.S. Department of Energy's (DOE) redesigned Web sites for the Alternative Fuels & Advanced Vehicles Data Center (AFDC) and the Clean Cities Program allow fleet managers and communities to make informed choices among strategies for reducing petroleum use. The resources are located on the AFDC and Clean Cities Web sites, which are developed and managed by DOE's National Renewable Energy Laboratory. The Web

  4. ORISE: Report shows nuclear engineering graduation rates leveling off in

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2014 after five years of increase ORISE report shows nuclear engineering graduation rates leveling off in 2014 after five years of increase Decline seen in undergraduate and master degrees, while number of doctoral degrees awarded increased FOR IMMEDIATE RELEASE July 31, 2015 FY15-38 OAK RIDGE, Tenn.-The number of college students graduating with majors in nuclear engineering has flattened and even declined somewhat after five straight years of continual increases, according to a report by

  5. ORISE: Report shows number of health physics degrees for 2010

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    report shows number of health physics degrees increased for graduates, decreased for undergraduates in 2010 Decreased number of B.S. degrees remains higher than levels in the early 2000 FOR IMMEDIATE RELEASE Dec. 20, 2011 FY12-09 OAK RIDGE, Tenn.-The number of health physics graduate degrees increased for both master's and doctoral candidates in 2010, but decreased for bachelor's degrees, says a report released this year by the Oak Ridge Institute for Science and Education. The ORISE report,

  6. Secretary Chu Speaks at the 2010 Washington Auto Show

    SciTech Connect (OSTI)

    Secretary Chu

    2010-02-03

    Secretary Chu lays out a roadmap for how the U.S. can lead the world in making the clean vehicles we need at the 2010 Washington Auto Show. He also announced that the Department of Energy had closed on a $1.4 billion loan to Nissan to build the all-electric LEAF in Tennessee and create up to 1,300 American jobs.

  7. Research Shows Ventilated Auto Seats Improve Fuel Economy, Comfort - News

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Releases | NREL Research Shows Ventilated Auto Seats Improve Fuel Economy, Comfort March 2, 2006 Golden, Colo. - The U.S. Department of Energy's National Renewable Energy Laboratory (NREL) has demonstrated that ventilated automotive seats not only can improve passenger comfort but also a vehicle's fuel economy. That's because ventilated seats keep drivers and passengers cooler, so they need less air conditioning to be comfortable. NREL's Vehicle Ancillary Loads Reduction team has been

  8. Modified Yeast Show Improved Xylose Fermentation and Toxin Tolerance -

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Innovation Portal Show Improved Xylose Fermentation and Toxin Tolerance Great Lakes Bioenergy Research Center Contact GLBRC About This Technology Technology Marketing Summary Bleaching plant material with alkaline hydrogen peroxide (AHP) is an old process used for papermaking. Several decades ago researchers suggested that this method also could be used in biofuel production. The method involves treating switchgrass or corn stover with hydrogen peroxide under basic conditions.

  9. NNSA administrator shows NM congressional delegation the Albuquerque

    National Nuclear Security Administration (NNSA)

    Complex to make case for new facility | National Nuclear Security Administration NNSA administrator shows NM congressional delegation the Albuquerque Complex to make case for new facility Friday, February 26, 2016 - 1:42pm WASHINGTON, DC - Lt. Gen. Frank Klotz (Ret.), Administrator of the Department of Energy's National Nuclear Security Administration, hosted two members of the New Mexico congressional delegation on Feb. 18 for a tour of the aging facilities occupied by 1,200 NNSA employees

  10. Secretary Chu Speaks at the 2010 Washington Auto Show

    ScienceCinema (OSTI)

    Secretary Chu

    2010-09-01

    Secretary Chu lays out a roadmap for how the U.S. can lead the world in making the clean vehicles we need at the 2010 Washington Auto Show. He also announced that the Department of Energy had closed on a $1.4 billion loan to Nissan to build the all-electric LEAF in Tennessee and create up to 1,300 American jobs.

  11. Los Alamos plasma research shows promise for future compact accelerators |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration Los Alamos plasma research shows promise for future compact accelerators Tuesday, January 12, 2016 - 12:00am NNSA Blog The team in front of Los Alamos' Trident Laser Target Chamber. Back, from left: Tom Shimada, Sha-Marie Reid, Adam Sefkow, Miguel Santiago, and Chris Hamilton. Front, from left: Russ Mortensen, Chengkun Huang, Sasi Palaniyappan, Juan Fernandez, Cort Gautier and Randy Johnson. A transformative breakthrough in controlling ion beams

  12. Stochastic Domain-Wall Depinning in Magnetic Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stochastic Domain-Wall Depinning in Magnetic Nanowires Stochastic Domain-Wall Depinning in Magnetic Nanowires Print Wednesday, 29 July 2009 00:00 Reliably controlling the motion of magnetic domain walls along magnetic nanowires is a key requirement for current technological development of novel classes of logic and storage devices, but understanding the nature of non-deterministic domain-wall motion remains a scientific challenge. A statistical analysis of high-resolution magnetic soft x-ray

  13. Dental optical coherence domain reflectometry explorer

    DOE Patents [OSTI]

    Everett, Matthew J.; Colston, Jr., Billy W.; Sathyam, Ujwal S.; Da Silva, Luiz B.

    2001-01-01

    A hand-held, fiber optic based dental device with optical coherence domain reflectometry (OCDR) sensing capabilities provides a profile of optical scattering as a function of depth in the tissue at the point where the tip of the dental explorer touches the tissue. This system provides information on the internal structure of the dental tissue, which is then used to detect caries and periodontal disease. A series of profiles of optical scattering or tissue microstructure are generated by moving the explorer across the tooth or other tissue. The profiles are combined to form a cross-sectional, or optical coherence tomography (OCT), image.

  14. Perovskite solar technology shows quick energy returns | Argonne National

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory Perovskite solar technology shows quick energy returns By Payal Marathe * July 17, 2015 Tweet EmailPrint Solar panels are an investment-not only in terms of money, but also energy. It takes energy to mine, process and purify raw materials, and then to manufacture and install the final product. Silicon-based panels, which dominate the market for solar power, usually need about two years to return this energy investment. But for technology made with perovskites-a class of materials

  15. Show your passion for innovation with a creative talk

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TechRev Day at Los Alamos ScienceFest Show your passion for innovation with a creative talk Organizers of Los Alamos ScienceFest are seeking innovative presentations from passionate people with a love of innovation. July 22, 2014 Credit: Los Alamos MainStreet Credit: Los Alamos MainStreet Contact James E. Rickman Communications Office (505) 665-9203 Email Potential TechRev Day presenters have until Aug. 8 to apply. Presentations sought for TechRev Day at Los Alamos ScienceFest LOS ALAMOS, N.M.,

  16. Inflationary power asymmetry from primordial domain walls

    SciTech Connect (OSTI)

    Jazayeri, Sadra; Akrami, Yashar; Firouzjahi, Hassan; Solomon, Adam R.; Wang, Yi E-mail: yashar.akrami@astro.uio.no E-mail: a.r.solomon@damtp.cam.ac.uk

    2014-11-01

    We study the asymmetric primordial fluctuations in a model of inflation in which translational invariance is broken by a domain wall. We calculate the corrections to the power spectrum of curvature perturbations; they are anisotropic and contain dipole, quadrupole, and higher multipoles with non-trivial scale-dependent amplitudes. Inspired by observations of these multipole asymmetries in terms of two-point correlations and variance in real space, we demonstrate that this model can explain the observed anomalous power asymmetry of the cosmic microwave background (CMB) sky, including its characteristic feature that the dipole dominates over higher multipoles. We test the viability of the model and place approximate constraints on its parameters by using observational values of dipole, quadrupole, and octopole amplitudes of the asymmetry measured by a local-variance estimator. We find that a configuration of the model in which the CMB sphere does not intersect the domain wall during inflation provides a good fit to the data. We further derive analytic expressions for the corrections to the CMB temperature covariance matrix, or angular power spectra, which can be used in future statistical analysis of the model in spherical harmonic space.

  17. EERE Web Domains and URLs | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Project Process & Approvals » EERE Web Domains and URLs EERE Web Domains and URLs For domains and URLs, all Office of Energy Efficiency and Renewable Energy (EERE) office and partnership websites must comply with the Department of Energy (DOE), the Office of Management and Budget (OMB), and the EERE domain policies. Getting Approval All domains must be approved by the Web Governance Team (WGT). For new Web projects, you'll include it on the Project Information Form, which you'll complete

  18. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain

    SciTech Connect (OSTI)

    Murphy, James M.; Korzhnev, Dmitry M.; Ceccarelli, Derek F.; Briant, Douglas J.; Zarrine-Afsar, Arash; Sicheri, Frank; Kay, Lewis E.; Pawson, Tony (Mount Sinai Hospital); (Toronto)

    2012-10-23

    The Par-1/MARK protein kinases play a pivotal role in establishing cellular polarity. This family of kinases contains a unique domain architecture, in which a ubiquitin-associated (UBA) domain is located C-terminal to the kinase domain. We have used a combination of x-ray crystallography and NMR dynamics experiments to understand the interaction of the human (h) MARK3 UBA domain with the adjacent kinase domain as compared with ubiquitin. The x-ray crystal structure of the linked hMARK3 kinase and UBA domains establishes that the UBA domain forms a stable intramolecular interaction with the N-terminal lobe of the kinase domain. However, solution-state NMR studies of the isolated UBA domain indicate that it is highly dynamic, undergoing conformational transitions that can be explained by a folding-unfolding equilibrium. NMR titration experiments indicated that the hMARK3 UBA domain has a detectable but extremely weak affinity for mono ubiquitin, which suggests that conformational instability of the isolated hMARK3 UBA domain attenuates binding to ubiquitin despite the presence of residues typically involved in ubiquitin recognition. Our data identify a molecular mechanism through which the hMARK3 UBA domain has evolved to bind the kinase domain, in a fashion that stabilizes an open conformation of the N- and C-terminal lobes, at the expense of its capacity to engage ubiquitin. These results may be relevant more generally to the 30% of UBA domains that lack significant ubiquitin-binding activity, and they suggest a unique mechanism by which interaction domains may evolve new binding properties.

  19. Birefringence insensitive optical coherence domain reflectometry system

    DOE Patents [OSTI]

    Everett, Matthew J.; Davis, Joseph G.

    2002-01-01

    A birefringence insensitive fiber optic optical coherence domain reflectometry (OCDR) system is provided containing non-polarization maintaining (non-PM) fiber in the sample arm and the reference arm without suffering from signal degradation caused by birefringence. The use of non-PM fiber significantly reduces the cost of the OCDR system and provides a disposable or multiplexed section of the sample arm. The dispersion in the reference arm and sample arm of the OCDR system are matched to achieve high resolution imaging. This system is useful in medical applications or for non-medical in situ probes. The disposable section of non-PM fiber in the sample arm can be conveniently replaced when contaminated by a sample or a patient.

  20. Magnetic domain structure in nanocrystalline Ni-Zn-Co spinel ferrite thin films using off-axis electron holography

    SciTech Connect (OSTI)

    Zhang, D.; Ray, N. M.; Petuskey, W. T.; Smith, D. J.; McCartney, M. R.

    2014-08-28

    We report a study of the magnetic domain structure of nanocrystalline thin films of nickel-zinc ferrite. The ferrite films were synthesized using aqueous spin-spray coating at low temperature (?90?C) and showed high complex permeability in the GHz range. Electron microscopy and microanalysis revealed that the films consisted of columnar grains with uniform chemical composition. Off-axis electron holography combined with magnetic force microscopy indicated a multi-grain domain structure with in-plane magnetization. The correlation between the magnetic domain morphology and crystal structure is briefly discussed.

  1. Stochastic Domain-Wall Depinning in Magnetic Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stochastic Domain-Wall Depinning in Magnetic Nanowires Print Reliably controlling the motion of magnetic domain walls along magnetic nanowires is a key requirement for current technological development of novel classes of logic and storage devices, but understanding the nature of non-deterministic domain-wall motion remains a scientific challenge. A statistical analysis of high-resolution magnetic soft x-ray microscopy images by a Berkeley Lab-University of Hamburg group has now revealed that

  2. Stochastic Domain-Wall Depinning in Magnetic Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stochastic Domain-Wall Depinning in Magnetic Nanowires Print Reliably controlling the motion of magnetic domain walls along magnetic nanowires is a key requirement for current technological development of novel classes of logic and storage devices, but understanding the nature of non-deterministic domain-wall motion remains a scientific challenge. A statistical analysis of high-resolution magnetic soft x-ray microscopy images by a Berkeley Lab-University of Hamburg group has now revealed that

  3. Stochastic Domain-Wall Depinning in Magnetic Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stochastic Domain-Wall Depinning in Magnetic Nanowires Print Reliably controlling the motion of magnetic domain walls along magnetic nanowires is a key requirement for current technological development of novel classes of logic and storage devices, but understanding the nature of non-deterministic domain-wall motion remains a scientific challenge. A statistical analysis of high-resolution magnetic soft x-ray microscopy images by a Berkeley Lab-University of Hamburg group has now revealed that

  4. Stochastic Domain-Wall Depinning in Magnetic Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stochastic Domain-Wall Depinning in Magnetic Nanowires Print Reliably controlling the motion of magnetic domain walls along magnetic nanowires is a key requirement for current technological development of novel classes of logic and storage devices, but understanding the nature of non-deterministic domain-wall motion remains a scientific challenge. A statistical analysis of high-resolution magnetic soft x-ray microscopy images by a Berkeley Lab-University of Hamburg group has now revealed that

  5. Stochastic Domain-Wall Depinning in Magnetic Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stochastic Domain-Wall Depinning in Magnetic Nanowires Print Reliably controlling the motion of magnetic domain walls along magnetic nanowires is a key requirement for current technological development of novel classes of logic and storage devices, but understanding the nature of non-deterministic domain-wall motion remains a scientific challenge. A statistical analysis of high-resolution magnetic soft x-ray microscopy images by a Berkeley Lab-University of Hamburg group has now revealed that

  6. Stochastic Domain-Wall Depinning in Magnetic Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stochastic Domain-Wall Depinning in Magnetic Nanowires Print Reliably controlling the motion of magnetic domain walls along magnetic nanowires is a key requirement for current technological development of novel classes of logic and storage devices, but understanding the nature of non-deterministic domain-wall motion remains a scientific challenge. A statistical analysis of high-resolution magnetic soft x-ray microscopy images by a Berkeley Lab-University of Hamburg group has now revealed that

  7. Stochastic Domain-Wall Depinning in Magnetic Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stochastic Domain-Wall Depinning in Magnetic Nanowires Print Reliably controlling the motion of magnetic domain walls along magnetic nanowires is a key requirement for current technological development of novel classes of logic and storage devices, but understanding the nature of non-deterministic domain-wall motion remains a scientific challenge. A statistical analysis of high-resolution magnetic soft x-ray microscopy images by a Berkeley Lab-University of Hamburg group has now revealed that

  8. Structural Basis for the Interaction between Pyk2-FAT Domain...

    Office of Scientific and Technical Information (OSTI)

    Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats Citation Details In-Document Search Title: Structural Basis for the Interaction between ...

  9. Death Domain Assembly Mechanism Revealed by Crystal Structure...

    Office of Scientific and Technical Information (OSTI)

    Core Complex Citation Details In-Document Search Title: Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex Authors: ...

  10. Stochastic Domain-Wall Depinning in Magnetic Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    concept called a racetrack memory, for example, the electron spin provides the driving force that moves a domain wall (boundary between regions of different magnetization) down...

  11. National Geothermal Data System (NGDS) Geothermal Data Domain...

    Open Energy Info (EERE)

    Geothermal Data System (NGDS) Geothermal Data Domain: Assessment of Geothermal Community Data Needs Jump to: navigation, search OpenEI Reference LibraryAdd to library Conference...

  12. Nonlinear Time Domain Modeling and Simulation of Surface and...

    Office of Environmental Management (EM)

    Jose Abell, Kohei Watanabe, Chao Luo University of California, Davis Lawrence Berkeley National Laboratory, Berkeley DOE NPH, October 2014 PDF icon Nonlinear Time Domain...

  13. Time-Domain Electromagnetics At Kilauea East Rift Geothermal...

    Open Energy Info (EERE)

    At Kilauea East Rift Geothermal Area (FURUMOTO, 1976) Exploration Activity Details Location Kilauea East Rift Geothermal Area Exploration Technique Time-Domain...

  14. Frequency-Domain Electromagnetics Survey At Kilauea East Rift...

    Open Energy Info (EERE)

    1976) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Frequency-Domain Electromagnetics Survey At Kilauea East Rift Geothermal Area (FURUMOTO,...

  15. Structure and Dynamics of Domains in Ferroelectric Nanostructures...

    Office of Scientific and Technical Information (OSTI)

    of ferroelectric domains in ferroelectric thin films and nanostructures by advanced transmission electron microscopy (TEM) techniques in close collaboration with phase field...

  16. Time-Domain Electromagnetics At Kilauea East Rift Geothermal...

    Open Energy Info (EERE)

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Kilauea East Rift Geothermal Area (Thomas, 1986) Exploration...

  17. Time-Domain Electromagnetics At Kilauea East Rift Geothermal...

    Open Energy Info (EERE)

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Kilauea East Rift Geothermal Area (Skokan, 1974) Exploration...

  18. Time-Domain Electromagnetics At Kilauea Southwest Rift And South...

    Open Energy Info (EERE)

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Kilauea Southwest Rift And South Flank Area (Thomas, 1986)...

  19. Time-Domain Electromagnetics At Hualalai Northwest Rift Area...

    Open Energy Info (EERE)

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Hualalai Northwest Rift Area (Thomas, 1986) Exploration...

  20. Time-Domain Electromagnetics At Mauna Loa Northeast Rift Area...

    Open Energy Info (EERE)

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Mauna Loa Northeast Rift Area (Thomas, 1986) Exploration...

  1. Time-Domain Electromagnetics At Glass Mountain Area (Cumming...

    Open Energy Info (EERE)

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Glass Mountain Area (Cumming And Mackie, 2007) Exploration...

  2. Time-Domain Electromagnetics At Haleakala Volcano Area (Thomas...

    Open Energy Info (EERE)

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Haleakala Volcano Area (Thomas, 1986) Exploration Activity...

  3. Time-Domain Electromagnetics At Truckhaven Area (Warpinski, Et...

    Open Energy Info (EERE)

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Truckhaven Area (Warpinski, Et Al., 2004) Exploration...

  4. Time-Domain Electromagnetics At Dixie Hot Springs Area (Combs...

    Open Energy Info (EERE)

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Dixie Hot Springs Area (Combs 2006) Exploration Activity...

  5. Organic Solar Cells: Absolute Measurement of Domain Composition...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Organic Solar Cells: Absolute Measurement of Domain Composition and Nanoscale Size Distribution Explains Performance in Solar Cells Organic Solar Cells: Absolute Measurement of...

  6. Controlled Source Frequency-Domain Magnetics (Montgomery, Et...

    Open Energy Info (EERE)

    (Montgomery, Et Al., 2005) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Controlled Source Frequency-Domain Magnetics (Montgomery, Et Al.,...

  7. Controlled Source Frequency-Domain Magnetics At Salt Wells Area...

    Open Energy Info (EERE)

    At Salt Wells Area (Montgomery, Et Al., 2005) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Controlled Source Frequency-Domain Magnetics At...

  8. Visualizing the Behavior of Polar Domains and Screening Charges...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Visualizing the Behavior of Polar Domains and Screening Charges Under Electric and Mechanical Fields Event Sponsor: Mathematics and Computing Science - LANS Seminar Start Date: Sep...

  9. Dual-domain lateral shearing interferometer

    DOE Patents [OSTI]

    Naulleau, Patrick P.; Goldberg, Kenneth Alan

    2004-03-16

    The phase-shifting point diffraction interferometer (PS/PDI) was developed to address the problem of at-wavelength metrology of extreme ultraviolet (EUV) optical systems. Although extremely accurate, the fact that the PS/PDI is limited to use with coherent EUV sources, such as undulator radiation, is a drawback for its widespread use. An alternative to the PS/PDI, with relaxed coherence requirements, is lateral shearing interferometry (LSI). The use of a cross-grating, carrier-frequency configuration to characterize a large-field 4.times.-reduction EUV lithography optic is demonstrated. The results obtained are directly compared with PS/PDI measurements. A defocused implementation of the lateral shearing interferometer in which an image-plane filter allows both phase-shifting and Fourier wavefront recovery. The two wavefront recovery methods can be combined in a dual-domain technique providing suppression of noise added by self-interference of high-frequency components in the test-optic wavefront.

  10. Catheter guided by optical coherence domain reflectometry

    DOE Patents [OSTI]

    Everett, Matthew (Pleasanton, CA); Colston, Billy W. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Matthews, Dennis (Moss Beach, CA)

    2002-01-01

    A guidance and viewing system based on multiplexed optical coherence domain reflectometry is incorporated into a catheter, endoscope, or other medical device to measure the location, thickness, and structure of the arterial walls or other intra-cavity regions at discrete points on the medical device during minimally invasive medical procedures. The information will be used both to guide the device through the body and to evaluate the tissue through which the device is being passed. Multiple optical fibers are situated along the circumference of the device. Light from the distal end of each fiber is directed onto the interior cavity walls via small diameter optics (such as gradient index lenses and mirrored corner cubes). Both forward viewing and side viewing fibers can be included. The light reflected or scattered from the cavity walls is then collected by the fibers and multiplexed at the proximal end to the sample arm of an optical low coherence reflectometer. The system may also be implemented in a nonmedical inspection device.

  11. Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus

    SciTech Connect (OSTI)

    Zhou, Dongwen; Chung, Suhman; Miller, Maria; Le Grice, Stuart F.J.; Wlodawer, Alexander

    2012-06-19

    The ribonuclease H (RNase H) domain of retroviral reverse transcriptase (RT) plays a critical role in the life cycle by degrading the RNA strands of DNA/RNA hybrids. In addition, RNase H activity is required to precisely remove the RNA primers from nascent (-) and (+) strand DNA. We report here three crystal structures of the RNase H domain of xenotropic murine leukemia virus-related virus (XMRV) RT, namely (i) the previously identified construct from which helix C was deleted, (ii) the intact domain, and (iii) the intact domain complexed with an active site {alpha}-hydroxytropolone inhibitor. Enzymatic assays showed that the intact RNase H domain retained catalytic activity, whereas the variant lacking helix C was only marginally active, corroborating the importance of this helix for enzymatic activity. Modeling of the enzyme-substrate complex elucidated the essential role of helix C in binding a DNA/RNA hybrid and its likely mode of recognition. The crystal structure of the RNase H domain complexed with {beta}-thujaplicinol clearly showed that coordination by two divalent cations mediates recognition of the inhibitor.

  12. Control of domain wall pinning by localised focused Ga {sup +} ion irradiation on Au capped NiFe nanowires

    SciTech Connect (OSTI)

    Burn, D. M. Atkinson, D.

    2014-10-28

    Understanding domain wall pinning and propagation in nanowires are important for future spintronics and nanoparticle manipulation technologies. Here, the effects of microscopic local modification of the magnetic properties, induced by focused-ion-beam intermixing, in NiFe/Au bilayer nanowires on the pinning behavior of domain walls was investigated. The effects of irradiation dose and the length of the irradiated features were investigated experimentally. The results are considered in the context of detailed quasi-static micromagnetic simulations, where the ion-induced modification was represented as a local reduction of the saturation magnetization. Simulations show that domain wall pinning behavior depends on the magnitude of the magnetization change, the length of the modified region, and the domain wall structure. Comparative analysis indicates that reduced saturation magnetisation is not solely responsible for the experimentally observed pinning behavior.

  13. Impact of the [delta]F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure

    SciTech Connect (OSTI)

    Lewis, Hal A.; Zhao, Xun; Wang, Chi; Sauder, J. Michael; Rooney, Isabelle; Noland, Brian W.; Lorimer, Don; Kearins, Margaret C.; Conners, Kris; Condon, Brad; Maloney, Peter C.; Guggino, William B.; Hunt, John F.; Emtage, Spencer (SG); (Columbia); (JHU)

    2010-07-19

    Cystic fibrosis is caused by defects in the cystic fibrosis transmembrane conductance regulator (CFTR), commonly the deletion of residue Phe-508 (DeltaF508) in the first nucleotide-binding domain (NBD1), which results in a severe reduction in the population of functional channels at the epithelial cell surface. Previous studies employing incomplete NBD1 domains have attributed this to aberrant folding of DeltaF508 NBD1. We report structural and biophysical studies on complete human NBD1 domains, which fail to demonstrate significant changes of in vitro stability or folding kinetics in the presence or absence of the DeltaF508 mutation. Crystal structures show minimal changes in protein conformation but substantial changes in local surface topography at the site of the mutation, which is located in the region of NBD1 believed to interact with the first membrane spanning domain of CFTR. These results raise the possibility that the primary effect of DeltaF508 is a disruption of proper interdomain interactions at this site in CFTR rather than interference with the folding of NBD1. Interestingly, increases in the stability of NBD1 constructs are observed upon introduction of second-site mutations that suppress the trafficking defect caused by the DeltaF508 mutation, suggesting that these suppressors might function indirectly by improving the folding efficiency of NBD1 in the context of the full-length protein. The human NBD1 structures also solidify the understanding of CFTR regulation by showing that its two protein segments that can be phosphorylated both adopt multiple conformations that modulate access to the ATPase active site and functional interdomain interfaces.

  14. Domain evolution and polarization of continuously graded ferroelectric films

    SciTech Connect (OSTI)

    Roytburd, A.; Roytburd, V.

    2008-01-01

    A thermodynamic analysis of graded ferroelectric films demonstrates that in the equilibrium state the films are subdivided into a single-domain band and a polydomain band which consists of wedge-shape domains. Polarization under an external electrostatic field proceeds through an inter-band boundary movement due to growth or shrinkage of the wedge domains. It is shown how the domain structure and evolution are determined by the principal characteristics of the film: the distribution of the spontaneous polarization and dielectric constant. Graded films exhibit a sharp increase of polarization with the field for weak fields, with a drop of the dielectric constant when the field is increasing. A general approach to finding the dependence of the displacement and the wedge-domain shape on the field as well as analytical solutions for the p{sup 4} Landau-Devonshire and parabolic potentials are presented.

  15. Hidden Rotational Symmetries in Magnetic Domain Patterns

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    low-temperature control, and high coherent x-ray flux. The sample used was a CoPd multilayer film that shows perpendicular anisotropy, meaning the magnetization points...

  16. Identifying ferroelectric phase and domain structure using angle-resolved piezoresponse force microscopy

    SciTech Connect (OSTI)

    Kim, K. L.; Huber, J. E.

    2014-03-24

    We used angle-resolved piezoresponse force microscopy (AR-PFM), vertical PFM (VPFM), and electron backscatter diffraction (EBSD) to provide a systematic interpretation of domain patterns in polycrystalline, near-morphotropic lead zirconate titanate. This material was used to illustrate the power of AR-PFM methods in resolving complex domain patterns where multiple phases may be present. AR-PFM was carried out with a 30° rotation interval, and the resulting data were analysed to identify the orientation of the underlying axis of piezoelectricity. The additional information provided by AR-PFM was studied, comparing its capabilities to those of 3-dimensional PFM, consisting of one VPFM image and two orthogonal lateral PFM (LPFM) images. We show that, in certain conditions, using AR-PFM can identify the phases present at the sub-grain scale. This was confirmed using VPFM and EBSD data. Furthermore, the method can discriminate laminated domain patterns that appear similar in VPFM and can reliably expose domain patterns that may not be seen in LPFM data from a single orientation, or even in 3D PFM data.

  17. The pilus usher controls protein interactions via domain masking and is functional as an oligomer

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Werneburg, Glenn T.; Li, Huilin; Henderson, Nadine S.; Portnoy, Erica B.; Sarowar, Samema; Hultgren, Scott J.; Thanassi, David G.

    2015-06-08

    The chaperone/usher (CU) pathway is responsible for biogenesis of organelles termed pili or fimbriae in Gram-negative bacteria. Type 1 pili expressed by uropathogenic Escherichia coli are prototypical structures assembled by the CU pathway. Assembly and secretion of pili by the CU pathway requires a dedicated periplasmic chaperone and a multidomain outer membrane protein termed the usher (FimD). We show that the FimD C-terminal domains provide the high-affinity substrate binding site, but that these domains are masked in the resting usher. Domain masking requires the FimD plug domain, which served as a central switch controlling usher activation. In addition, we demonstratemore » that usher molecules can act in trans for pilus biogenesis, providing conclusive evidence for a functional usher oligomer. These results reveal mechanisms by which molecular machines such as the usher regulate and harness protein-protein interactions, and suggest that ushers may interact in a cooperative manner during pilus assembly in bacteria.« less

  18. Time domain analysis of a gyrotron traveling wave amplifier with misaligned electron beam

    SciTech Connect (OSTI)

    Wang, Qiushi Peng, Shuyuan; Luo, Jirun

    2014-08-15

    This article develops a time-domain theory to study the beam-wave interaction in gyrotron traveling wave amplifier (gyro-TWA) with a misaligned electron beam. The effects of beam misalignment on the TE{sub 01} mode gyro-TWA operating at the fundamental are discussed. Numerical results show that the effect of misalignment is less obvious when the input power is larger, and the influences of misalignment on the stable gain and the stable time are basically opposite.

  19. Smart Grid Conceptual Actors/Data Flow Diagram- Cross Domain...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PDF icon Smart Grid Conceptual ActorsData Flow Diagram- Cross Domain Network Focued- Open SGSG-Network TF More Documents & Publications Report to NIST on the Smart Grid ...

  20. Magnetic anisotropy and domain structure of the layered manganite...

    Office of Scientific and Technical Information (OSTI)

    1.64Mnsub 2Osub 7 Citation Details In-Document Search Title: Magnetic anisotropy and domain structure of the layered manganite Lasub 1.36Srsub 1.64Mnsub 2Osub ...

  1. Ferroelasticity and domain physics in two-dimensional transition metal

    Office of Scientific and Technical Information (OSTI)

    dichalcogenide monolayers (Journal Article) | DOE PAGES Accepted Manuscript: Ferroelasticity and domain physics in two-dimensional transition metal dichalcogenide monolayers « Prev Next » Title: Ferroelasticity and domain physics in two-dimensional transition metal dichalcogenide monolayers Monolayers of transition metal dichalcogenides can exist in several structural polymorphs, including 2H, 1T and 1T'. The low-symmetry 1T' phase has three orientation variants, resulting from the three

  2. In situ measurement of increased ferroelectric/ferroelastic domain wall

    Office of Scientific and Technical Information (OSTI)

    motion in declamped tetragonal lead zirconate titanate thin films (Journal Article) | DOE PAGES Publisher's Accepted Manuscript: In situ measurement of increased ferroelectric/ferroelastic domain wall motion in declamped tetragonal lead zirconate titanate thin films « Prev Next » Title: In situ measurement of increased ferroelectric/ferroelastic domain wall motion in declamped tetragonal lead zirconate titanate thin films Authors: Wallace, M. [1] Search DOE PAGES for author "Wallace,

  3. Initiation factor 2 crystal structure reveals a different domain

    Office of Scientific and Technical Information (OSTI)

    organization from eukaryotic initiation factor 5B and mechanism among translational GTPases (Journal Article) | SciTech Connect Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases Citation Details In-Document Search Title: Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases Authors:

  4. Organic Solar Cells: Absolute Measurement of Domain Composition and

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nanoscale Size Distribution Explains Performance in Solar Cells Organic Solar Cells: Absolute Measurement of Domain Composition and Nanoscale Size Distribution Explains Performance in Solar Cells Organic Solar Cells: Absolute Measurement of Domain Composition and Nanoscale Size Distribution Explains Performance in Solar Cells Print Tuesday, 22 January 2013 00:00 This front cover represents the morphology and resulting device dynamics in organic solar cell blend films of PTB7 and PC71BM, as

  5. Nucleon transverse momentum-dependent parton distributions from domain wall

    Office of Scientific and Technical Information (OSTI)

    fermion calculations at 297 MeV pion mass (Conference) | SciTech Connect Conference: Nucleon transverse momentum-dependent parton distributions from domain wall fermion calculations at 297 MeV pion mass Citation Details In-Document Search Title: Nucleon transverse momentum-dependent parton distributions from domain wall fermion calculations at 297 MeV pion mass Lattice QCD calculations of transverse momentum-dependent parton distributions (TMDs) in a nucleon are performed based on a

  6. Death Domain Assembly Mechanism Revealed by Crystal Structure of the

    Office of Scientific and Technical Information (OSTI)

    Oligomeric PIDDosome Core Complex (Journal Article) | SciTech Connect SciTech Connect Search Results Journal Article: Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex Citation Details In-Document Search Title: Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex Authors: Park, Hyun Ho ; Logette, Emmanuelle ; Rausnser, Stefan ; Cuenin, Solange ; Walz, Thomas ; Tschopp, Jurg ; Wu, Hao [1] ;

  7. Antiferromagnetism and domain effects in UPdSn

    SciTech Connect (OSTI)

    Nakotte, H. [Manual Lujan Jr. Neutron Scattering Center, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)] [Manual Lujan Jr. Neutron Scattering Center, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); [Department of Physics, New Mexico State University, Las Cruces, New Mexico 88003 (United States); Robinson, R.A.; Purwanto, A. [Manuel Lujan Jr. Neutron Scattering Center, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)] [Manuel Lujan Jr. Neutron Scattering Center, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Tun, Z. [Chalk River Laboratories, Atomic Energy of Canada Limited, Chalk River, Ontario, K0J 1J0 (CANADA)] [Chalk River Laboratories, Atomic Energy of Canada Limited, Chalk River, Ontario, K0J 1J0 (CANADA); Prokes, K.; Brueck, E.; de Boer, F.R. [Van der Waals-Zeeman Institute, University of Amsterdam, 1018 XE Amsterdam (The Netherlands)] [Van der Waals-Zeeman Institute, University of Amsterdam, 1018 XE Amsterdam (The Netherlands)

    1998-10-01

    Neutron-diffraction experiments have been performed on a single crystal of the hexagonal noncollinear antiferromagnetic compound UPdSn as a function of temperature and magnetic field. The use of a special horizontal-field magnet (with very wide horizontal access to the neutron beams) has allowed the study of the principal magnetic Bragg reflections in all three antiferromagnetic domain pairs throughout the magnetic phase diagram for B{lt}3thinspT and T{gt}6thinspK. The data confirm a picture in which one domain pair (1) grows at the expense of the other two domain pairs (2 and 3), for fields along the [100] axis for domain 1. On the other hand, if the field is applied along the perpendicular axis, [010] for domain 1, the other two domains are preferred. These results are consistent with the picture given in a previous vertical-field study of only one magnetic reflection from one domain, in which the 3-T field-induced transition is viewed as a spin-flop transition. There is, however, a small amount of irreversible moment rotation (from {theta}=43{degree} to 48{degree}, where {theta} is the moment canting angle within the hexagonal basal plane), on passing through the spin-flop transition. This seems to be connected with whether the sample is single or multidomain. In addition, the field independence of the N{acute e}el temperature (T{sub N}=37thinspK) has been measured up to 3 T, and data on the domain kinetics are presented. {copyright} {ital 1998} {ital The American Physical Society}

  8. Micro- and nano-domain engineering in lithium niobate

    SciTech Connect (OSTI)

    Shur, V. Ya.; Akhmatkhanov, A. R.; Baturin, I. S.

    2015-12-15

    The physical basis of the domain engineering in ferroelectrics and its application to lithium niobate crystals were reviewed. The unified kinetic approach to the domain structure evolution in electric field was formulated and its validity for understanding the variety of observed domain evolution scenarios was demonstrated. The kinetics and statics of the domain structure in the crystals of lithium niobate family including congruent, stoichiometric, and MgO doped ones have been discussed. The main stages of the periodical poling process and related problems have been pointed out. The basic poling techniques applied for creation of the periodical domain structures in bulk crystals and waveguides were compared. The recent applications of the periodically poled lithium niobate for light frequency conversion using second harmonic generation and optical parametric oscillation, excitation of the surface acoustic waves, and generation of terahertz radiation have been discussed. The special attention has been paid for achievements in fabrication of high-power optical parametric oscillation and integrated optical devices with periodically poled lithium niobate. The future trends in periodical poling and development of the nanodomain engineering which will allow to create the nanoscale domain patterns necessary for utilization of the new nonlinear interactions were reviewed.

  9. Circular single domains in hemispherical Permalloy nanoclusters

    SciTech Connect (OSTI)

    Araujo, Clodoaldo I. L de Fonseca, Jakson M.; Sinnecker, Joo P.; Delatorre, Rafael G.; Garcia, Nicolas; Pasa, Andr A.

    2014-11-14

    We have studied ferromagnetic Permalloy clusters obtained by electrodeposition on n-type silicon. Magnetization measurements reveal hysteresis loops almost independent on temperature and very similar in shape to those obtained in nanodisks with diameter bigger than 150?nm. The spin configuration for the ground state, obtained by micromagnetic simulation, shows topological vortices with random chirality and polarization. This behavior in the small diameter clusters (?80?nm) is attributed to the Dzyaloshinskii-Moriya interaction that arises in its hemispherical geometries. This magnetization behavior can be utilized to explain the magnetoresistance measured with magnetic field in plane and out of sample plane.

  10. Evaluating the coherence and time-domain profile of quantum cascade laser frequency combs

    SciTech Connect (OSTI)

    Burghoff, David; Yang, Yang; Hayton, Darren J.; Gao, Jian -Rong; Reno, John L.; Hu, Qing

    2015-01-01

    Recently, much attention has been focused on the generation of optical frequency combs from quantum cascade lasers. We discuss how fast detectors can be used to demonstrate the mutual coherence of such combs, and present an inequality that can be used to quantitatively evaluate their performance. We discuss several technical issues related to shifted wave interference Fourier Transform spectroscopy (SWIFTS), and show how such measurements can be used to elucidate the time-domain properties of such combs, showing that they can possess signatures of both frequency-modulation and amplitude-modulation.

  11. The domains of instability for the pulsating PG1159 stars.

    SciTech Connect (OSTI)

    Quirion, P.-O.; Fontaine, Gilles.; Brassard, Pierre; Herwig, F. H.

    2004-01-01

    The fact that we find pulsating and nonpulsating stars mixed together in the PG 1159 region of the log g - T{sub eff} diagram has been a long standing puzzle. The poor understanding of the driving mechanism in those stars has been the reason why it has taken so long to address properly this problem. Following the work of Saio (1996) and Gautschy (1997) based on the OPAL opacities, Quirion, Fontaine, & Brassard (2004) recently showed that we are now able to understand and reproduce the ranges of observed periods in the pulsating PG 1159 stars in terms of the original {kappa}-mechanism associated with the partial ionization of the K-shell electrons of C and O which, along with He, make up the composition of the envelope of those stars. Contrary to others, those three studies agree in that no composition gradients are needed between the atmospheric layers and the driving region. Furthermore, the cohabitation of pulsating and nonpulsating PG 1159 stars is naturally explained in terms of a dispersion in atmospheric parameters and in terms of a variation in surface composition from star to star. In particular, the most He-rich stars tend to be stable. We go beyond the findings discussed by Quirion et al. (2004) in this paper, and present the results of additional calculations aimed at describing better the role of the chemical composition (in particular the role of metallicity) as well as that of the stellar mass on the boundaries of the instability domain in the log g - T{sub eff} plane.

  12. Assessment of current cybersecurity practices in the public domain : cyber indications and warnings domain.

    SciTech Connect (OSTI)

    Hamlet, Jason R.; Keliiaa, Curtis M.

    2010-09-01

    This report assesses current public domain cyber security practices with respect to cyber indications and warnings. It describes cybersecurity industry and government activities, including cybersecurity tools, methods, practices, and international and government-wide initiatives known to be impacting current practice. Of particular note are the U.S. Government's Trusted Internet Connection (TIC) and 'Einstein' programs, which are serving to consolidate the Government's internet access points and to provide some capability to monitor and mitigate cyber attacks. Next, this report catalogs activities undertaken by various industry and government entities. In addition, it assesses the benchmarks of HPC capability and other HPC attributes that may lend themselves to assist in the solution of this problem. This report draws few conclusions, as it is intended to assess current practice in preparation for future work, however, no explicit references to HPC usage for the purpose of analyzing cyber infrastructure in near-real-time were found in the current practice. This report and a related SAND2010-4766 National Cyber Defense High Performance Computing and Analysis: Concepts, Planning and Roadmap report are intended to provoke discussion throughout a broad audience about developing a cohesive HPC centric solution to wide-area cybersecurity problems.

  13. Domain pinning near a single-grain boundary in tetragonal and...

    Office of Scientific and Technical Information (OSTI)

    Domain pinning near a single-grain boundary in tetragonal and rhombohedral lead zirconate ... Title: Domain pinning near a single-grain boundary in tetragonal and rhombohedral lead ...

  14. Structure of the SPRY domain of human Ash2L and its interactions with RbBP5

    Office of Scientific and Technical Information (OSTI)

    and DPY30 (Journal Article) | SciTech Connect Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30 Citation Details In-Document Search Title: Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30 Authors: Chen, Yong ; Cao, Fang ; Wan, Bingbing ; Dou, Yali ; Lei, Ming [1] + Show Author Affiliations (Michigan-Med) Publication Date: 2013-10-07 OSTI Identifier: 1093479 Resource Type: Journal Article Resource Relation: Journal Name:

  15. A 1.3-Å Structure of Zinc-bound N-terminal Domain of Calmodulin Elucidates

    Office of Scientific and Technical Information (OSTI)

    Potential Early Ion-binding Step (Journal Article) | SciTech Connect Journal Article: A 1.3-Å Structure of Zinc-bound N-terminal Domain of Calmodulin Elucidates Potential Early Ion-binding Step Citation Details In-Document Search Title: A 1.3-Å Structure of Zinc-bound N-terminal Domain of Calmodulin Elucidates Potential Early Ion-binding Step Authors: Warren, Julia T. ; Guo, Qing ; Tang, Wei-Jen [1] + Show Author Affiliations (UC) Publication Date: 2015-11-02 OSTI Identifier: 1222846

  16. Real-time observation of epitaxial graphene domain reorientation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Thuermer, Konrad; Foster, Michael E.; Bartelt, Norman Charles; Rogge, Paul C.; Lawrence Berkeley National Lab.; McCarty, Kevin F.; Dubon, Oscar D.; Lawrence Berkeley National Lab.; Bartelt, Norman C.

    2015-04-20

    Graphene films grown by vapour deposition tend to be polycrystalline due to the nucleation and growth of islands with different in-plane orientations. Here, using low-energy electron microscopy, we find that micron-sized graphene islands on Ir(111) rotate to a preferred orientation during thermal annealing. We observe three alignment mechanisms: the simultaneous growth of aligned domains and dissolution of rotated domains, that is, ‘ripening’; domain boundary motion within islands; and continuous lattice rotation of entire domains. By measuring the relative growth velocity of domains during ripening, we estimate that the driving force for alignment is on the order of 0.1 meV permore » C atom and increases with rotation angle. A simple model of the orientation-dependent energy associated with the moiré corrugation of the graphene sheet due to local variations in the graphene–substrate interaction reproduces the results. This study suggests new strategies for improving the van der Waals epitaxy of 2D materials.« less

  17. Magnetoelectric domain wall dynamics and its implications for magnetoelectric memory

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Belashchenko, K. D.; Tchernyshyov, O.; Kovalev, Alexey A.; Tretiakov, O. A.

    2016-03-30

    Domain wall dynamics in a magnetoelectric antiferromagnet is analyzed, and its implications for magnetoelectric memory applications are discussed. Cr2O3 is used in the estimates of the materials parameters. It is found that the domain wall mobility has a maximum as a function of the electric field due to the gyrotropic coupling induced by it. In Cr2O3, the maximal mobility of 0.1 m/(s Oe) is reached at E≈0.06 V/nm. Fields of this order may be too weak to overcome the intrinsic depinning field, which is estimated for B-doped Cr2O3. These major drawbacks for device implementation can be overcome by applying amore » small in-plane shear strain, which blocks the domain wall precession. Domain wall mobility of about 0.7 m/(s Oe) can then be achieved at E = 0.2 V/nm. Furthermore, a split-gate scheme is proposed for the domain-wall controlled bit element; its extension to multiple-gate linear arrays can offer advantages in memory density, programmability, and logic functionality.« less

  18. Sampling Approaches for Multi-Domain Internet Performance Measurement Infrastructures

    SciTech Connect (OSTI)

    Calyam, Prasad

    2014-09-15

    The next-generation of high-performance networks being developed in DOE communities are critical for supporting current and emerging data-intensive science applications. The goal of this project is to investigate multi-domain network status sampling techniques and tools to measure/analyze performance, and thereby provide “network awareness” to end-users and network operators in DOE communities. We leverage the infrastructure and datasets available through perfSONAR, which is a multi-domain measurement framework that has been widely deployed in high-performance computing and networking communities; the DOE community is a core developer and the largest adopter of perfSONAR. Our investigations include development of semantic scheduling algorithms, measurement federation policies, and tools to sample multi-domain and multi-layer network status within perfSONAR deployments. We validate our algorithms and policies with end-to-end measurement analysis tools for various monitoring objectives such as network weather forecasting, anomaly detection, and fault-diagnosis. In addition, we develop a multi-domain architecture for an enterprise-specific perfSONAR deployment that can implement monitoring-objective based sampling and that adheres to any domain-specific measurement policies.

  19. Frequency-domain multiscale quantum mechanics/electromagnetics simulation method

    SciTech Connect (OSTI)

    Meng, Lingyi; Yin, Zhenyu; Yam, ChiYung E-mail: ghc@everest.hku.hk; Koo, SiuKong; Chen, GuanHua E-mail: ghc@everest.hku.hk; Chen, Quan; Wong, Ngai

    2013-12-28

    A frequency-domain quantum mechanics and electromagnetics (QM/EM) method is developed. Compared with the time-domain QM/EM method [Meng et al., J. Chem. Theory Comput. 8, 11901199 (2012)], the newly developed frequency-domain QM/EM method could effectively capture the dynamic properties of electronic devices over a broader range of operating frequencies. The system is divided into QM and EM regions and solved in a self-consistent manner via updating the boundary conditions at the QM and EM interface. The calculated potential distributions and current densities at the interface are taken as the boundary conditions for the QM and EM calculations, respectively, which facilitate the information exchange between the QM and EM calculations and ensure that the potential, charge, and current distributions are continuous across the QM/EM interface. Via Fourier transformation, the dynamic admittance calculated from the time-domain and frequency-domain QM/EM methods is compared for a carbon nanotube based molecular device.

  20. Domain wall and isocurvature perturbation problems in axion models

    SciTech Connect (OSTI)

    Kawasaki, Masahiro; Yoshino, Kazuyoshi; Yanagida, Tsutomu T. E-mail: tsutomu.tyanagida@ipmu.jp

    2013-11-01

    Axion models have two serious cosmological problems, domain wall and isocurvature perturbation problems. In order to solve these problems we investigate the Linde's model in which the field value of the Peccei-Quinn (PQ) scalar is large during inflation. In this model the fluctuations of the PQ field grow after inflation through the parametric resonance and stable axionic strings may be produced, which results in the domain wall problem. We study formation of axionic strings using lattice simulations. It is found that in chaotic inflation the axion model is free from both the domain wall and the isocurvature perturbation problems if the initial misalignment angle ?{sub a} is smaller than O(10{sup ?2}). Furthermore, axions can also account for the dark matter for the breaking scale v ? 10{sup 12?16}GeV and the Hubble parameter during inflation H{sub inf}?<10{sup 11?12}GeV in general inflation models.

  1. Iterative image-domain decomposition for dual-energy CT

    SciTech Connect (OSTI)

    Niu, Tianye; Dong, Xue; Petrongolo, Michael; Zhu, Lei

    2014-04-15

    Purpose: Dual energy CT (DECT) imaging plays an important role in advanced imaging applications due to its capability of material decomposition. Direct decomposition via matrix inversion suffers from significant degradation of image signal-to-noise ratios, which reduces clinical values of DECT. Existing denoising algorithms achieve suboptimal performance since they suppress image noise either before or after the decomposition and do not fully explore the noise statistical properties of the decomposition process. In this work, the authors propose an iterative image-domain decomposition method for noise suppression in DECT, using the full variance-covariance matrix of the decomposed images. Methods: The proposed algorithm is formulated in the form of least-square estimation with smoothness regularization. Based on the design principles of a best linear unbiased estimator, the authors include the inverse of the estimated variance-covariance matrix of the decomposed images as the penalty weight in the least-square term. The regularization term enforces the image smoothness by calculating the square sum of neighboring pixel value differences. To retain the boundary sharpness of the decomposed images, the authors detect the edges in the CT images before decomposition. These edge pixels have small weights in the calculation of the regularization term. Distinct from the existing denoising algorithms applied on the images before or after decomposition, the method has an iterative process for noise suppression, with decomposition performed in each iteration. The authors implement the proposed algorithm using a standard conjugate gradient algorithm. The method performance is evaluated using an evaluation phantom (Catphan600) and an anthropomorphic head phantom. The results are compared with those generated using direct matrix inversion with no noise suppression, a denoising method applied on the decomposed images, and an existing algorithm with similar formulation as the proposed method but with an edge-preserving regularization term. Results: On the Catphan phantom, the method maintains the same spatial resolution on the decomposed images as that of the CT images before decomposition (8 pairs/cm) while significantly reducing their noise standard deviation. Compared to that obtained by the direct matrix inversion, the noise standard deviation in the images decomposed by the proposed algorithm is reduced by over 98%. Without considering the noise correlation properties in the formulation, the denoising scheme degrades the spatial resolution to 6 pairs/cm for the same level of noise suppression. Compared to the edge-preserving algorithm, the method achieves better low-contrast detectability. A quantitative study is performed on the contrast-rod slice of Catphan phantom. The proposed method achieves lower electron density measurement error as compared to that by the direct matrix inversion, and significantly reduces the error variation by over 97%. On the head phantom, the method reduces the noise standard deviation of decomposed images by over 97% without blurring the sinus structures. Conclusions: The authors propose an iterative image-domain decomposition method for DECT. The method combines noise suppression and material decomposition into an iterative process and achieves both goals simultaneously. By exploring the full variance-covariance properties of the decomposed images and utilizing the edge predetection, the proposed algorithm shows superior performance on noise suppression with high image spatial resolution and low-contrast detectability.

  2. The HPr Proteins from the Thermophile Bacillus stearothermophilus Can Form Domain-swapped Dimers

    SciTech Connect (OSTI)

    Sridharan, Sudharsan; Razvi, Abbas; Scholtz, J. Martin; Sacchettini, James C. (TAM)

    2010-07-20

    The study of proteins from extremophilic organisms continues to generate interest in the field of protein folding because paradigms explaining the enhanced stability of these proteins still elude us and such studies have the potential to further our knowledge of the forces stabilizing proteins. We have undertaken such a study with our model protein HPr from a mesophile, Bacillus subtilis, and a thermophile, Bacillus stearothermophilus. We report here the high-resolution structures of the wild-type HPr protein from the thermophile and a variant, F29W. The variant proved to crystallize in two forms: a monomeric form with a structure very similar to the wild-type protein as well as a domain-swapped dimer. Interestingly, the structure of the domain-swapped dimer for HPr is very different from that observed for a homologous protein, Crh, from B. subtilis. The existence of a domain-swapped dimer has implications for amyloid formation and is consistent with recent results showing that the HPr proteins can form amyloid fibrils. We also characterized the conformational stability of the thermophilic HPr proteins using thermal and solvent denaturation methods and have used the high-resolution structures in an attempt to explain the differences in stability between the different HPr proteins. Finally, we present a detailed analysis of the solution properties of the HPr proteins using a variety of biochemical and biophysical methods.

  3. Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway

    SciTech Connect (OSTI)

    Hwang, Eunha; Cheong, Hae-Kap; Mushtaq, Ameeq Ul; Kim, Hye-Yeon; Yeo, Kwon Joo; Kim, Eunhee; Lee, Woo Cheol; Hwang, Kwang Yeon; Cheong, Chaejoon; Jeon, Young Ho

    2014-07-01

    The heterodimeric structure of the MST1 and RASSF5 SARAH domains is presented. A comparison of homodimeric and heterodimeric interactions provides a structural basis for the preferential association of the SARAH heterodimer. Despite recent progress in research on the Hippo signalling pathway, the structural information available in this area is extremely limited. Intriguingly, the homodimeric and heterodimeric interactions of mammalian sterile 20-like (MST) kinases through the so-called ‘SARAH’ (SAV/RASSF/HPO) domains play a critical role in cellular homeostasis, dictating the fate of the cell regarding cell proliferation or apoptosis. To understand the mechanism of the heterodimerization of SARAH domains, the three-dimensional structures of an MST1–RASSF5 SARAH heterodimer and an MST2 SARAH homodimer were determined by X-ray crystallography and were analysed together with that previously determined for the MST1 SARAH homodimer. While the structure of the MST2 homodimer resembled that of the MST1 homodimer, the MST1–RASSF5 heterodimer showed distinct structural features. Firstly, the six N-terminal residues (Asp432–Lys437), which correspond to the short N-terminal 3{sub 10}-helix h1 kinked from the h2 helix in the MST1 homodimer, were disordered. Furthermore, the MST1 SARAH domain in the MST1–RASSF5 complex showed a longer helical structure (Ser438–Lys480) than that in the MST1 homodimer (Val441–Lys480). Moreover, extensive polar and nonpolar contacts in the MST1–RASSF5 SARAH domain were identified which strengthen the interactions in the heterodimer in comparison to the interactions in the homodimer. Denaturation experiments performed using urea also indicated that the MST–RASSF heterodimers are substantially more stable than the MST homodimers. These findings provide structural insights into the role of the MST1–RASSF5 SARAH domain in apoptosis signalling.

  4. Current Domain Challenges in the Emergency Response Community

    SciTech Connect (OSTI)

    Barr, Jonathan L.; Peddicord, Annie M Boe; Burtner, Edwin R.; Mahy, Heidi A.

    2011-05-08

    This paper describes the development of a framework targeted to technology providers in order to better understand the grand domain challenges of the emergency response and management community (EM). In developing this framework, Pacific Northwest National Laboratory researchers interviewed subject matter experts (SMEs) across the EM domain and corroborated these findings with current literature. We are currently examining relationships and dependencies within the framework. A thorough understanding of these gaps and dependencies will allow for a more informed approach prioritizing research, developing tools, and applying technology to enhance performance in the EM community.

  5. Insights into substrate specificity of NlpC/P60 cell wall hydrolases containing bacterial SH3 domains

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xu, Qingping; Mengin-Lecreulx, Dominique; Liu, Xueqian W.; Patin, Delphine; Farr, Carol L.; Grant, Joanna C.; Chiu, Hsiu -Ju; Jaroszewski, Lukasz; Knuth, Mark W.; Godzik, Adam; et al

    2015-09-15

    Bacterial SH3 (SH3b) domains are commonly fused with papain-like Nlp/P60 cell wall hydrolase domains. To understand how the modular architecture of SH3b and NlpC/P60 affects the activity of the catalytic domain, three putative NlpC/P60 cell wall hydrolases were biochemically and structurally characterized. In addition, these enzymes all have γ-d-Glu-A2pm (A2pm is diaminopimelic acid) cysteine amidase (ordl-endopeptidase) activities but with different substrate specificities. One enzyme is a cell wall lysin that cleaves peptidoglycan (PG), while the other two are cell wall recycling enzymes that only cleave stem peptides with an N-terminall-Ala. Their crystal structures revealed a highly conserved structure consisting ofmore » two SH3b domains and a C-terminal NlpC/P60 catalytic domain, despite very low sequence identity. Interestingly, loops from the first SH3b domain dock into the ends of the active site groove of the catalytic domain, remodel the substrate binding site, and modulate substrate specificity. Two amino acid differences at the domain interface alter the substrate binding specificity in favor of stem peptides in recycling enzymes, whereas the SH3b domain may extend the peptidoglycan binding surface in the cell wall lysins. Remarkably, the cell wall lysin can be converted into a recycling enzyme with a single mutation.Peptidoglycan is a meshlike polymer that envelops the bacterial plasma membrane and bestows structural integrity. Cell wall lysins and recycling enzymes are part of a set of lytic enzymes that target covalent bonds connecting the amino acid and amino sugar building blocks of the PG network. These hydrolases are involved in processes such as cell growth and division, autolysis, invasion, and PG turnover and recycling. To avoid cleavage of unintended substrates, these enzymes have very selective substrate specificities. Our biochemical and structural analysis of three modular NlpC/P60 hydrolases, one lysin, and two recycling enzymes, show that they may have evolved from a common molecular architecture, where the substrate preference is modulated by local changes. These results also suggest that new pathways for recycling PG turnover products, such as tracheal cytotoxin, may have evolved in bacteria in the human gut microbiome that involve NlpC/P60 cell wall hydrolases.« less

  6. Insights into substrate specificity of NlpC/P60 cell wall hydrolases containing bacterial SH3 domains

    SciTech Connect (OSTI)

    Xu, Qingping; Mengin-Lecreulx, Dominique; Liu, Xueqian W.; Patin, Delphine; Farr, Carol L.; Grant, Joanna C.; Chiu, Hsiu -Ju; Jaroszewski, Lukasz; Knuth, Mark W.; Godzik, Adam; Lesley, Scott A.; Elsliger, Marc -André; Deacon, Ashley M.; Wilson, Ian A.

    2015-09-15

    Bacterial SH3 (SH3b) domains are commonly fused with papain-like Nlp/P60 cell wall hydrolase domains. To understand how the modular architecture of SH3b and NlpC/P60 affects the activity of the catalytic domain, three putative NlpC/P60 cell wall hydrolases were biochemically and structurally characterized. In addition, these enzymes all have γ-d-Glu-A2pm (A2pm is diaminopimelic acid) cysteine amidase (ordl-endopeptidase) activities but with different substrate specificities. One enzyme is a cell wall lysin that cleaves peptidoglycan (PG), while the other two are cell wall recycling enzymes that only cleave stem peptides with an N-terminall-Ala. Their crystal structures revealed a highly conserved structure consisting of two SH3b domains and a C-terminal NlpC/P60 catalytic domain, despite very low sequence identity. Interestingly, loops from the first SH3b domain dock into the ends of the active site groove of the catalytic domain, remodel the substrate binding site, and modulate substrate specificity. Two amino acid differences at the domain interface alter the substrate binding specificity in favor of stem peptides in recycling enzymes, whereas the SH3b domain may extend the peptidoglycan binding surface in the cell wall lysins. Remarkably, the cell wall lysin can be converted into a recycling enzyme with a single mutation.

    Peptidoglycan is a meshlike polymer that envelops the bacterial plasma membrane and bestows structural integrity. Cell wall lysins and recycling enzymes are part of a set of lytic enzymes that target covalent bonds connecting the amino acid and amino sugar building blocks of the PG network. These hydrolases are involved in processes such as cell growth and division, autolysis, invasion, and PG turnover and recycling. To avoid cleavage of unintended substrates, these enzymes have very selective substrate specificities. Our biochemical and structural analysis of three modular NlpC/P60 hydrolases, one lysin, and two recycling enzymes, show that they may have evolved from a common molecular architecture, where the substrate preference is modulated by local changes. These results also suggest that new pathways for recycling PG turnover products, such as tracheal cytotoxin, may have evolved in bacteria in the human gut microbiome that involve NlpC/P60 cell wall hydrolases.

  7. Methods of use of cellulose binding domain proteins

    DOE Patents [OSTI]

    Shoseyov, O.; Shpiegl, I.; Goldstein, M.A.; Doi, R.H.

    1997-09-23

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques. 16 figs.

  8. Methods of use of cellulose binding domain proteins

    DOE Patents [OSTI]

    Shoseyov, Oded; Shpiegl, Itai; Goldstein, Marc A.; Doi, Roy H.

    1997-01-01

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.

  9. Methods of detection using a cellulose binding domain fusion product

    DOE Patents [OSTI]

    Shoseyov, O.; Shpiegl, I.; Goldstein, M.A.; Doi, R.H.

    1999-01-05

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques. 34 figs.

  10. Methods of detection using a cellulose binding domain fusion product

    DOE Patents [OSTI]

    Shoseyov, Oded; Shpiegl, Itai; Goldstein, Marc A.; Doi, Roy H.

    1999-01-01

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.

  11. Dynamic frequency-domain interferometer for absolute distance measurements with high resolution

    SciTech Connect (OSTI)

    Weng, Jidong; Liu, Shenggang; Ma, Heli; Tao, Tianjiong; Wang, Xiang; Liu, Cangli; Tan, Hua

    2014-11-15

    A unique dynamic frequency-domain interferometer for absolute distance measurement has been developed recently. This paper presents the working principle of the new interferometric system, which uses a photonic crystal fiber to transmit the wide-spectrum light beams and a high-speed streak camera or frame camera to record the interference stripes. Preliminary measurements of harmonic vibrations of a speaker, driven by a radio, and the changes in the tip clearance of a rotating gear wheel show that this new type of interferometer has the ability to perform absolute distance measurements both with high time- and distance-resolution.

  12. Decay-ratio calculation in the frequency domain with the LAPUR code using 1D-kinetics

    SciTech Connect (OSTI)

    Munoz-Cobo, J. L.; Escriva, A.; Garcia, C.; Berna, C.

    2012-07-01

    This paper deals with the problem of computing the Decay Ratio in the frequency domain codes as the LAPUR code. First, it is explained how to calculate the feedback reactivity in the frequency domain using slab-geometry i.e. 1D kinetics, also we show how to perform the coupling of the 1D kinetics with the thermal-hydraulic part of the LAPUR code in order to obtain the reactivity feedback coefficients for the different channels. In addition, we show how to obtain the reactivity variation in the complex domain by solving the eigenvalue equation in the frequency domain and we compare this result with the reactivity variation obtained in first order perturbation theory using the 1D neutron fluxes of the base case. Because LAPUR works in the linear regime, it is assumed that in general the perturbations are small. There is also a section devoted to the reactivity weighting factors used to couple the reactivity contribution from the different channels to the reactivity of the entire reactor core in point kinetics and 1D kinetics. Finally we analyze the effects of the different approaches on the DR value. (authors)

  13. Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution

    SciTech Connect (OSTI)

    Chen, Liqing Wang, Yujun; Wells, David; Toh, Diana; Harold, Hunt; Zhou, Jing; DiGiammarino, Enrico; Meehan, Edward J.

    2006-09-01

    The crystal structure of the SH3 domain of human osteoclast-stimulating factor has been determined and refined to the ultrahigh resolution of 1.07 . The structure at atomic resolution provides an accurate framework for structure-based design of its inhibitors. Osteoclast-stimulating factor (OSF) is an intracellular signaling protein, produced by osteoclasts themselves, that enhances osteoclast formation and bone resorption. It is thought to act via an Src-related signaling pathway and contains SH3 and ankyrin-repeat domains which are involved in proteinprotein interactions. As part of a structure-based anti-bone-loss drug-design program, the atomic resolution X-ray structure of the recombinant human OSF SH3 domain (hOSF-SH3) has been determined. The domain, residues 1272, yielded crystals that diffracted to the ultrahigh resolution of 1.07 . The overall structure shows a characteristic SH3 fold consisting of two perpendicular ?-sheets that form a ?-barrel. Structure-based sequence alignment reveals that the putative proline-rich peptide-binding site of hOSF-SH3 consists of (i) residues that are highly conserved in the SH3-domain family, including residues Tyr21, Phe23, Trp49, Pro62, Asn64 and Tyr65, and (ii) residues that are less conserved and/or even specific to hOSF, including Thr22, Arg26, Thr27, Glu30, Asp46, Thr47, Asn48 and Leu60, which might be key to designing specific inhibitors for hOSF to fight osteoporosis and related bone-loss diseases. There are a total of 13 well defined water molecules forming hydrogen bonds with the above residues in and around the peptide-binding pocket. Some of those water molecules might be important for drug-design approaches. The hOSF-SH3 structure at atomic resolution provides an accurate framework for structure-based design of its inhibitors.

  14. Time Domain Partitioning of Electricity Production Cost Simulations

    SciTech Connect (OSTI)

    Barrows, C.; Hummon, M.; Jones, W.; Hale, E.

    2014-01-01

    Production cost models are often used for planning by simulating power system operations over long time horizons. The simulation of a day-ahead energy market can take several weeks to compute. Tractability improvements are often made through model simplifications, such as: reductions in transmission modeling detail, relaxation of commitment variable integrality, reductions in cost modeling detail, etc. One common simplification is to partition the simulation horizon so that weekly or monthly horizons can be simulated in parallel. However, horizon partitions are often executed with overlap periods of arbitrary and sometimes zero length. We calculate the time domain persistence of historical unit commitment decisions to inform time domain partitioning of production cost models. The results are implemented using PLEXOS production cost modeling software in an HPC environment to improve the computation time of simulations while maintaining solution integrity.

  15. Stopbands in the existence domains of acoustic solitons

    SciTech Connect (OSTI)

    Nsengiyumva, F. Hellberg, M. A. Mace, R. L.; Verheest, F.

    2014-10-15

    A fully nonlinear Sagdeev pseudopotential approach is used to study the existence domain of fast mode ion-acoustic solitons in a three-species plasma composed of cold and warm adiabatic positive ion species and Boltzmann electrons. It is shown that for appropriate values of the cold-to-warm ion charge-to-mass ratio, ?, and the effective warm ion-to-electron temperature ratio, ?, there is a range in cold to warm ion charge density ratio, f, over which a stopband in soliton speed exists. Solitons do not propagate in the stopband, although they can occur for both higher and lower speeds. The stopbands are associated with a limiting curve of the existence domain that is double-valued in speed for a range of values of f. Analytical estimates of the upper and lower limits of ? and ? that support stopbands are found. It is suggested that, inter alia, the analysis should be applicable to the solar wind plasma.

  16. Domain-independent information extraction in unstructured text

    SciTech Connect (OSTI)

    Irwin, N.H.

    1996-09-01

    Extracting information from unstructured text has become an important research area in recent years due to the large amount of text now electronically available. This status report describes the findings and work done during the second year of a two-year Laboratory Directed Research and Development Project. Building on the first-year`s work of identifying important entities, this report details techniques used to group words into semantic categories and to output templates containing selective document content. Using word profiles and category clustering derived during a training run, the time-consuming knowledge-building task can be avoided. Though the output still lacks in completeness when compared to systems with domain-specific knowledge bases, the results do look promising. The two approaches are compatible and could complement each other within the same system. Domain-independent approaches retain appeal as a system that adapts and learns will soon outpace a system with any amount of a priori knowledge.

  17. Investigation of Unusual Albedos in the SGP Domain

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Investigation of Unusual Albedos in the SGP Domain Groff, David ARM SGP Duchon, Claude University Of Oklahoma Category: Atmospheric State and Surface We investigate the cause of unusually high albedos at an Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) extended facility near Morris, OK. In a previous study, daily albedos were calculated at several SGP extended facilities for 1998 and 1999 using broadband (.28 to 3 microns) pyranometers. The average daily albedo during this

  18. BuD, a helixloophelix DNA-binding domain for genome modification

    SciTech Connect (OSTI)

    Stella, Stefano; Molina, Rafael; Lpez-Mndez, Blanca; Juillerat, Alexandre; Bertonati, Claudia; Daboussi, Fayza; Campos-Olivas, Ramon; Duchateau, Phillippe; Montoya, Guillermo

    2014-07-01

    Crystal structures of BurrH and the BurrHDNA complex are reported. DNA editing offers new possibilities in synthetic biology and biomedicine for modulation or modification of cellular functions to organisms. However, inaccuracy in this process may lead to genome damage. To address this important problem, a strategy allowing specific gene modification has been achieved through the addition, removal or exchange of DNA sequences using customized proteins and the endogenous DNA-repair machinery. Therefore, the engineering of specific proteinDNA interactions in protein scaffolds is key to providing toolkits for precise genome modification or regulation of gene expression. In a search for putative DNA-binding domains, BurrH, a protein that recognizes a 19 bp DNA target, was identified. Here, its apo and DNA-bound crystal structures are reported, revealing a central region containing 19 repeats of a helixloophelix modular domain (BurrH domain; BuD), which identifies the DNA target by a single residue-to-nucleotide code, thus facilitating its redesign for gene targeting. New DNA-binding specificities have been engineered in this template, showing that BuD-derived nucleases (BuDNs) induce high levels of gene targeting in a locus of the human haemoglobin ? (HBB) gene close to mutations responsible for sickle-cell anaemia. Hence, the unique combination of high efficiency and specificity of the BuD arrays can push forward diverse genome-modification approaches for cell or organism redesign, opening new avenues for gene editing.

  19. Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcript...

    Office of Scientific and Technical Information (OSTI)

    Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity Citation Details In-Document Search Title: Impact of the N-Terminal Domain of STAT3 in ...

  20. Structure and Interactions of the CS Domain of Human H/ACA RNP...

    Office of Scientific and Technical Information (OSTI)

    Structure and Interactions of the CS Domain of Human HACA RNP Assembly Protein Shq1 Citation Details In-Document Search Title: Structure and Interactions of the CS Domain of Human...

  1. Structure of the SPRY domain of human Ash2L and its interactions...

    Office of Scientific and Technical Information (OSTI)

    Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30 Citation Details In-Document Search Title: Structure of the SPRY domain of human Ash2L and its ...

  2. Solar and the City: Online Map to Show NYC's Solar Potential...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and the City: Online Map to Show NYC's Solar Potential Solar and the City: Online Map to Show NYC's Solar Potential October 13, 2010 - 11:32am Addthis Stephen Graff Former Writer & ...

  3. Zip is not in file but shows on EUR | OpenEI Community

    Open Energy Info (EERE)

    Zip is not in file but shows on EUR Home > Groups > Utility Rate Hello, I was looking up electricity providers for the zipcode 90050. While it shows a result using the tool at...

  4. Two New Studies Show How Energy Consumers Respond to Smart Grid Technology

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy New Studies Show How Energy Consumers Respond to Smart Grid Technology Two New Studies Show How Energy Consumers Respond to Smart Grid Technology February 14, 2011 - 3:24pm Addthis Home-energy display mobile phone application that shows how much energy an appliance is consuming. | Photo courtesy of Pecan Street Project. Home-energy display mobile phone application that shows how much energy an appliance is consuming. | Photo courtesy of Pecan Street Project. Matt

  5. Propagating and reflecting of spin wave in permalloy nanostrip with 360 domain wall

    SciTech Connect (OSTI)

    Zhang, Senfu; Mu, Congpu; Zhu, Qiyuan; Zheng, Qi; Liu, Xianyin; Wang, Jianbo; Liu, Qingfang

    2014-01-07

    By micromagnetic simulation, we investigated the interaction between propagating spin wave (or magnonic) and a 360 domain wall in a nanostrip. It is found that propagating spin wave can drive a 360 domain wall motion, and the velocity and direction are closely related to the transmission coefficient of the spin wave of the domain wall. When the spin wave passes through the domain wall completely, the 360 domain wall moves toward the spin wave source. When the spin wave is reflected by the domain wall, the 360 domain wall moves along the spin wave propagation direction. Moreover, when the frequency of the spin wave is coincident with that of the 360 domain wall normal mode, the 360 domain wall velocity will be resonantly enhanced no matter which direction the 360 DW moves along. On the other hand, when the spin wave is reflected from the moving 360 domain wall, we observed the Doppler effect clearly. After passing through a 360 domain wall, the phase of the spin wave is changed, and the phase shift is related to the frequency. Nevertheless, phase shift could be manipulated by the number of 360 domain walls that spin wave passing through.

  6. Fabrication of single crystalline, uniaxial single domain Co nanowire arrays with high coercivity

    SciTech Connect (OSTI)

    Ramazani, A. Almasi Kashi, M.; Montazer, A. H.

    2014-03-21

    Whilst Co nanorods with high coercivity were synthesized during recent years, they did not achieve the same results as for Co nanowires embedded in solid templates. In the present work, Co nanowire arrays (NWAs) with high coercivity were successfully fabricated in porous aluminum oxide template under optimum conditions by using pulsed ac electrodeposition technique. Magnetic properties and crystalline characteristics of the nanowires were investigated by hysteresis loop measurements, first-order reversal curve (FORC) analysis, X-ray diffraction (XRD), and selected area electron diffraction (SAED) patterns. Hysteresis loop measurements showed high coercivity of about 4.8 kOe at room temperature together with optimum squareness of 1, resulting in an increase of the previous maximum coercivity for Co NWAs up to 45%. XRD and SAED patterns revealed a single crystalline texture along the [0002] direction, indicating the large magnetocrystalline anisotropy. On the other hand, FORC analysis confirmed a single domain structure for the Co NWAs. In addition, the reversal mechanism of the single crystalline, single domain Co NWAs was studied which resulted in the fixed easy axis with a coherent rotation. Accordingly, these nanowires might offer promising applications in high density bit patterned media and low power logic devices.

  7. Interplay between intrinsic and stacking-fault magnetic domains in bi-layered manganites

    SciTech Connect (OSTI)

    Hossain, M.A; Burkhardt, Mark H.; Sarkar, S.; Ohldag, H.; Chuang, Y.-D.; Scholl, A.; Young, A.T.; Doran, A.; Dessau, D.S.; Zheng, H.; Mitchell, J.F.; Durr, H.A.; Stohr, J.

    2012-09-11

    We present a low temperature X-ray photoemission electron microscopy study of the bi-layered manganite compound La{sub 1.2}Sr{sub 1.8}Mn{sub 2}O{sub 7} (BL-LSMO) to investigate the influence of stacking faults, which are structurally and magnetically different from the bi-layered host. In BL-LSMO small magnetic moment persists to T* = 300K, well above the Curie temperature of 120K (T{sub C}). Our magnetic images show that 3D stacking faults are responsible for the T* transition. Furthermore, close to the T{sub C}, stacking faults are well coupled to the bi-layered host with latter magnetic domains controlling the spin direction of the stacking faults. Contrary to recent reports, we find that stacking faults do not seed magnetic domains in the host via an exchange spring mechanism and the intrinsic T{sub C} of the BL-LSMO is not lower than 120K.

  8. Example Work Domain Analysis for a Reference Sodium Fast Reactor

    SciTech Connect (OSTI)

    Hugo, Jacques; Oxstrand, Johanna

    2015-01-01

    The nuclear industry is currently designing and building a new generation of reactors that will include different structural, functional, and environmental aspects, all of which are likely to have a significant impact on the way these plants are operated. In order to meet economic and safety objectives, these new reactors will all use advanced technologies to some extent, including new materials and advanced digital instrumentation and control systems. New technologies will affect not only operational strategies, but will also require a new approach to how functions are allocated to humans or machines to ensure optimal performance. Uncertainty about the effect of large scale changes in plant design will remain until sound technical bases are developed for new operational concepts and strategies. Up-to-date models and guidance are required for the development of operational concepts for complex socio-technical systems. This report describes how the classical Work Domain Analysis method was adapted to develop operational concept frameworks for new plants. This adaptation of the method is better able to deal with the uncertainty and incomplete information typical of first-of-a-kind designs. Practical examples are provided of the systematic application of the method in the operational analysis of sodium-cooled reactors. Insights from this application and its utility are reviewed and arguments for the formal adoption of Work Domain Analysis as a value-added part of the Systems Engineering process are presented.

  9. Phylogenomic and functional domain analysis of polyketide synthases in Fusarium

    SciTech Connect (OSTI)

    Brown, Daren W.; Butchko, Robert A.; Baker, Scott E.; Proctor, Robert H.

    2012-02-01

    Fusarium species are ubiquitous in nature, cause a range of plant diseases, and produce a variety of chemicals often referred to as secondary metabolites. Although some fungal secondary metabolites affect plant growth or protect plants from other fungi and bacteria, their presence in grain based food and feed is more often associated with a variety of diseases in plants and in animals. Many of these structurally diverse metabolites are derived from a family of related enzymes called polyketide synthases (PKSs). A search of genomic sequence of Fusarium verticillioides, F. graminearum, F. oxysporum and Nectria haematococca (anamorph F. solani) identified a total of 58 PKS genes. To gain insight into how this gene family evolved and to guide future studies, we conducted a phylogenomic and functional domain analysis. The resulting genealogy suggested that Fusarium PKSs represent 34 different groups responsible for synthesis of different core metabolites. The analyses indicate that variation in the Fusarium PKS gene family is due to gene duplication and loss events as well as enzyme gain-of-function due to the acquisition of new domains or of loss-of-function due to nucleotide mutations. Transcriptional analysis indicate that the 16 F. verticillioides PKS genes are expressed under a range of conditions, further evidence that they are functional genes that confer the ability to produce secondary metabolites.

  10. Parametric Study of the Frequency-Domain Thermoreflectance Technique

    SciTech Connect (OSTI)

    C. Xing; C. Jensen; Z. Hua; H. Ban; D. H. Hurley; M. Khafizov; J. Rory Kennedy

    2012-11-01

    Without requiring regression for parameter determination, one-dimensional (1D) analytical models are used by many research groups to extract the thermal properties in frequency-domain thermoreflectance measurements. Experimentally, this approach involves heating the sample with a pump laser and probing the temperature response with spatially coincident probe laser. Micron order lateral resolution can be obtained by tightly focusing the pump and probe lasers. However, small laser beam spot sizes necessarily bring into question the assumptions associated with 1D analytical models. In this study, we analyzed the applicability of 1D analytical models by comparing to 2D analytical and fully numerical models. Specifically, we considered a generic nlayer two-dimensional (2D), axisymmetric analytical model including effects of volumetric heat absorption, contact resistance, and anisotropic properties. In addition, a finite element numerical model was employed to consider nonlinear effects caused by temperature dependent thermal conductivity. Nonlinearity is of germane importance to frequency domain approaches because the experimental geometry is such that the probe is always sensing the maximum temperature fluctuation. To quantify the applicability of the 1D model, parametric studies were performed considering the effects of: film thickness, heating laser size, probe laser size, substrate-to-film effusivity ratio, interfacial thermal resistance between layers, volumetric heating, substrate thermal conductivity, nonlinear boundary conditions, and anisotropic and temperature dependent thermal conductivity.

  11. Domain-Specific Languages for Composing Signature Discovery Workflows

    SciTech Connect (OSTI)

    Jacob, Ferosh; Gray, Jeff; Wynne, Adam S.; Liu, Yan; Baker, Nathan A.

    2012-10-23

    Domain-agnostic signature discovery entails investigation across multiple scientific disciplines. The breadth and cross-disciplinary nature of this work requires that existing executables be integrated with new capabilities into workflows, representing a wide range of user tasks. An algorithm may be written in multiple programming languages for various hardware platforms, and so workflow composition requires integrating executables from any number of remote hosts. This raises an engineering issue on how to generate web service wrappers for these heterogeneous executables and to compose them into a scientific workflow environment (e.g., Taverna). In this paper, we introduce two simple Domain-Specific Languages (DSLs) to automate these processes. Our Service Description Language (SDL) describes key elements of a signature discovery service and automatically generates its implementation code. The Workflow Description Language (WDL) describes the pipeline of services and generates deployable artifacts for the Taverna workflow management system. We demonstrate our approach with a real-world workflow composed of services wrapping remote executables.

  12. David Friedman: On the Future of Transportation and the LA Auto Show |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy David Friedman: On the Future of Transportation and the LA Auto Show David Friedman: On the Future of Transportation and the LA Auto Show Addthis Description David Friedman, Principal Deputy Assistant Secretary in the Energy Department's Office of Energy Efficiency & Renewable Energy (EERE), visited the L.A. Auto Show in November 2015. In this video interview, he shared his thoughts about transportation's future, the exciting technologies being introduced to the

  13. The #LabsRoadShow: National Lab Contributions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The #LabsRoadShow: National Lab Contributions The #LabsRoadShow: National Lab Contributions July 27, 2015 - 1:03am Addthis The #LabsRoadShow: National Lab Contributions Pat Adams Pat Adams Digital Content Specialist, Office of Public Affairs How can I participate? Follow along all week on social media with #LabsRoadShow. Meet the National Labs. Join us on Friday, 7/31 at 1p.m. ET on Facebook for a Q&A on particle physics. Last month you had the chance to meet the National Labs. Now it's time

  14. Buckle up for the #LabsRoadShow | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Buckle up for the #LabsRoadShow Buckle up for the #LabsRoadShow June 29, 2015 - 11:42am Addthis Buckle up for the #LabsRoadShow Pat Adams Pat Adams Digital Content Specialist, Office of Public Affairs How can I participate? Follow along all week on social media with #LabsRoadShow. Learn more about the National Laboratories. Tune in next month for Stop Two: Lab Contributions With the Fourth of July right around the corner, what's more American than taking a road trip? Join us as we embark on the

  15. Latest Report Shows Cost of Going Solar has Dropped Significantly for 5

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Years | Department of Energy Latest Report Shows Cost of Going Solar has Dropped Significantly for 5 Years Latest Report Shows Cost of Going Solar has Dropped Significantly for 5 Years August 12, 2015 - 2:28pm Addthis Latest Report Shows Cost of Going Solar has Dropped Significantly for 5 Years Lawrence Berkeley National Lab today released the eighth installment of the Tracking the Sun report series, which is funded by the U.S. Department of Energy SunShot Initiative. The report shows that

  16. Crystal structure of the N-terminal region of human Ash2L shows...

    Office of Scientific and Technical Information (OSTI)

    Authors: Chen, Yong ; Wan, Bingbing ; Wang, Kevin C. ; Cao, Fang ; Yang, Yuting ; Protacio, Angeline ; Dou, Yali ; Chang, Howard Y. ; Lei, Ming 1 ; HHMI) 2 + Show Author ...

  17. NREL data set shows clouds' effects on solar power - News Releases...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    data set shows clouds' effects on solar power Measurement stations in Hawaii gauge ... The U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL)has ...

  18. Current-driven domain wall motion enhanced by the microwave field

    SciTech Connect (OSTI)

    Wang, Xi-guang; Guo, Guang-hua Nie, Yao-zhuang; Wang, Dao-wei; Li, Zhi-xiong; Tang, Wei; Zeng, Zhong-ming

    2014-07-14

    The magnetic domain wall (DW) motion driven by a spin-polarized current opens a new concept for memory and logic devices. However, the critical current density required to overcome the intrinsic and/or extrinsic pinning of DW remains too large for practical applications. Here, we show, by using micromagnetic simulations and analytical approaches, that the application of a microwave field offers an effective solution to this problem. When a transverse microwave field is applied, the adiabatic spin-transfer torque (STT) alone can sustain a steady-state DW motion without the sign of Walker breakdown, meaning that the intrinsic pinning disappears. The extrinsic pinning can also be effectively reduced. Moreover, the DW velocity is increased greatly for the microwave-assisted DW motion. This provides a new way to manipulate the DW motion at low current densities.

  19. Spectral evolution of two-dimensional kinetic plasma turbulence in the wavenumber-frequency domain

    SciTech Connect (OSTI)

    Comi?el, H.; Institute for Space Sciences, Atomi?tilor 409, P.O. Box MG-23, Bucharest-M?gurele RO-077125 ; Verscharen, D.; Narita, Y.; Motschmann, U.; Deutsches Zentrum fr Luft- und Raumfahrt, Institut fr Planetenforschung, Rutherfordstr. 2, D-12489 Berlin

    2013-09-15

    We present a method for studying the evolution of plasma turbulence by tracking dispersion relations in the energy spectrum in the wavenumber-frequency domain. We apply hybrid plasma simulations in a simplified two-dimensional geometry to demonstrate our method and its applicability to plasma turbulence in the ion kinetic regime. We identify four dispersion relations: ion-Bernstein waves, oblique whistler waves, oblique Alfvn/ion-cyclotron waves, and a zero-frequency mode. The energy partition and frequency broadening are evaluated for these modes. The method allows us to determine the evolution of decaying plasma turbulence in our restricted geometry and shows that it cascades along the dispersion relations during the early phase with an increasing broadening around the dispersion relations.

  20. Energy Secretary Moniz at the 2016 Washington Auto Show | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Secretary Moniz at the 2016 Washington Auto Show Energy Secretary Moniz at the 2016 Washington Auto Show Addthis Topic Loans Alternative Fuel Vehicles Hydrogen Hydrogen & Fuel Cells Learn about some of the amazing Energy Department-supported vehicle technologies that are lowering carbon pollution and driving America's clean energy economy forward.

  1. Investigation of dominant spin wave modes by domain walls collision

    SciTech Connect (OSTI)

    Ramu, M.; Purnama, I.; Goolaup, S.; Chandra Sekhar, M.; Lew, W. S.

    2014-06-28

    Spin wave emission due to field-driven domain wall (DW) collision has been investigated numerically and analytically in permalloy nanowires. The spin wave modes generated are diagonally symmetric with respect to the collision point. The non-propagating mode has the highest amplitude along the middle of the width. The frequency of this mode is strongly correlated to the nanowire geometrical dimensions and is independent of the strength of applied field within the range of 0.1?mT to 1?mT. For nanowire with film thickness below 5?nm, a second spin wave harmonic mode is observed. The decay coefficient of the spin wave power suggests that the DWs in a memory device should be at least 300?nm apart for them to be free of interference from the spin waves.

  2. Depinning transition of a domain wall in ferromagnetic films

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xi, Bin; Luo, Meng -Bo; Vinokur, Valerii M.; Hu, Xiao

    2015-09-14

    We report first principle numerical study of domain wall (DW) depinning in two-dimensional magnetic film, which is modeled by 2D random-field Ising system with the dipole-dipole interaction. We observe non-conventional activation-type motion of DW and reveal the fractal structure of DW near the depinning transition. We determine scaling functions describing critical dynamics near the transition and obtain universal exponents establishing connection between thermal softening of pinning potential and critical dynamics. In addition, we observe that tuning the strength of the dipole-dipole interaction switches DW dynamics between two different universality classes, corresponding to two distinct dynamic regimes characterized by non-Arrhenius andmore » conventional Arrhenius-type DW motions.« less

  3. Time-domain reflectometry (TDR) in geotechnics: A review

    SciTech Connect (OSTI)

    Benson, C.H.; Bosscher, P.J.

    1999-07-01

    Time-domain reflectometry (TDR) is an electromagnetic geophysical technique used in the geosciences to measure water content of unfrozen and frozen soils and concentrations of inorganic solutes. In geotechnical and geological engineering, TDR is used for the same purposes, and also to measure frost depths, water levels, and displacements in soil and rock. Nevertheless, geo-engineers use TDR far less frequently than geo-scientists, primarily because they are unfamiliar with the technology. One purpose of this paper is to explain in practical terms how TDR is used in geo-engineering in each of the aforementioned applications. These descriptions reference the important publications in the literature. Another purpose is to share some of the authors' practical experience using TDR in the field.

  4. Ion mobility spectrometer using frequency-domain separation

    DOE Patents [OSTI]

    Martin, Stephen J.; Butler, Michael A.; Frye, Gregory C.; Schubert, W. Kent

    1998-01-01

    An apparatus and method is provided for separating and analyzing chemical species in an ion mobility spectrometer using a frequency-domain technique wherein the ions generated from the chemical species are selectively transported through an ion flow channel having a moving electrical potential therein. The moving electrical potential allows the ions to be selected according to ion mobility, with certain of the ions being transported to an ion detector and other of the ions being effectively discriminated against. The apparatus and method have applications for sensitive chemical detection and analysis for monitoring of exhaust gases, hazardous waste sites, industrial processes, aerospace systems, non-proliferation, and treaty verification. The apparatus can be formed as a microelectromechanical device (i.e. a micromachine).

  5. Ion mobility spectrometer using frequency-domain separation

    DOE Patents [OSTI]

    Martin, S.J.; Butler, M.A.; Frye, G.C.; Schubert, W.K.

    1998-08-04

    An apparatus and method are provided for separating and analyzing chemical species in an ion mobility spectrometer using a frequency-domain technique wherein the ions generated from the chemical species are selectively transported through an ion flow channel having a moving electrical potential therein. The moving electrical potential allows the ions to be selected according to ion mobility, with certain of the ions being transported to an ion detector and other of the ions being effectively discriminated against. The apparatus and method have applications for sensitive chemical detection and analysis for monitoring of exhaust gases, hazardous waste sites, industrial processes, aerospace systems, non-proliferation, and treaty verification. The apparatus can be formed as a microelectromechanical device (i.e. a micromachine). 6 figs.

  6. Aspen: A Domain Specific Language for Performance Modeling

    SciTech Connect (OSTI)

    Spafford, Kyle L; Vetter, Jeffrey S

    2012-01-01

    We present a new approach to analytical performance modeling using Aspen, a domain specific language. Aspen (Abstract Scalable Performance Engineering Notation) fills an important gap in existing performance modeling techniques and is designed to enable rapid exploration of new algorithms and architectures. It includes a formal specification of an application's performance behavior and an abstract machine model. We provide an overview of Aspen's features and demonstrate how it can be used to express a performance model for a three dimensional Fast Fourier Transform. We then demonstrate the composability and modularity of Aspen by importing and reusing the FFT model in a molecular dynamics model. We have also created a number of tools that allow scientists to balance application and system factors quickly and accurately.

  7. Depinning transition of a domain wall in ferromagnetic films

    SciTech Connect (OSTI)

    Xi, Bin; Luo, Meng -Bo; Vinokur, Valerii M.; Hu, Xiao

    2015-09-14

    We report first principle numerical study of domain wall (DW) depinning in two-dimensional magnetic film, which is modeled by 2D random-field Ising system with the dipole-dipole interaction. We observe non-conventional activation-type motion of DW and reveal the fractal structure of DW near the depinning transition. We determine scaling functions describing critical dynamics near the transition and obtain universal exponents establishing connection between thermal softening of pinning potential and critical dynamics. In addition, we observe that tuning the strength of the dipole-dipole interaction switches DW dynamics between two different universality classes, corresponding to two distinct dynamic regimes characterized by non-Arrhenius and conventional Arrhenius-type DW motions.

  8. Uncertainty in terahertz time-domain spectroscopy measurement

    SciTech Connect (OSTI)

    Withayachumnankul, Withawat; Fischer, Bernd M.; Lin Hungyen; Abbott, Derek

    2008-06-15

    Measurements of optical constants at terahertz--or T-ray--frequencies have been performed extensively using terahertz time-domain spectroscopy (THz-TDS). Spectrometers, together with physical models explaining the interaction between a sample and T-ray radiation, are progressively being developed. Nevertheless, measurement errors in the optical constants, so far, have not been systematically analyzed. This situation calls for a comprehensive analysis of measurement uncertainty in THz-TDS systems. The sources of error existing in a terahertz spectrometer and throughout the parameter estimation process are identified. The analysis herein quantifies the impact of each source on the output optical constants. The resulting analytical model is evaluated against experimental THz-TDS data.

  9. X-ray Imaging Shows Feather Patterns of First Birds | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    X-ray Imaging Shows Feather Patterns of First Birds X-ray Imaging Shows Feather Patterns of First Birds June 30, 2011 - 2:56pm Addthis A collage of images. Top, optical images of: blue jay feather, squid, and fossil fish with feather. Bottom: x-ray images showing the distribution of copper (red) in the same organisms. | Photo Courtesy of Gregory Stewart, SLAC National Accelerator Laboratory A collage of images. Top, optical images of: blue jay feather, squid, and fossil fish with feather.

  10. NETL's 2015 Carbon Storage Atlas Shows Increase in U.S. CO2 Storage

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Potential | Department of Energy NETL's 2015 Carbon Storage Atlas Shows Increase in U.S. CO2 Storage Potential NETL's 2015 Carbon Storage Atlas Shows Increase in U.S. CO2 Storage Potential September 28, 2015 - 9:49am Addthis The U.S. Department of Energy's (DOE) National Energy Technology Laboratory (NETL) today released the fifth edition of the Carbon Storage Atlas (Atlas V), which shows prospective carbon dioxide (CO2) storage resources of at least 2,600 billion metric tons - an increase

  11. New Report Shows Downward Trend in LCOE for Wind | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Shows Downward Trend in LCOE for Wind New Report Shows Downward Trend in LCOE for Wind May 18, 2015 - 2:48pm Addthis A new report recently published by the U.S. Department of Energy's National Renewable Energy Laboratory shows a downward trend in levelized cost of energy (LCOE) for both land-based and offshore wind projects since 2010. The 2013 Cost of Wind Energy Review presents a picture of the levelized cost of land-based and offshore wind energy using real and modeled data that represents

  12. New Report Shows Trend Toward Larger Offshore Wind Systems, with 11

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Advanced Stage Projects Proposed in U.S. Waters | Department of Energy Report Shows Trend Toward Larger Offshore Wind Systems, with 11 Advanced Stage Projects Proposed in U.S. Waters New Report Shows Trend Toward Larger Offshore Wind Systems, with 11 Advanced Stage Projects Proposed in U.S. Waters October 23, 2013 - 10:52am Addthis The Energy Department today released a new report showing progress for the U.S. offshore wind energy market in 2012, including the completion of two commercial

  13. David Friedman: On the Future of Transportation and the L.A. Auto Show |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy David Friedman: On the Future of Transportation and the L.A. Auto Show David Friedman: On the Future of Transportation and the L.A. Auto Show January 6, 2016 - 8:45am Addthis A conversation with David Friedman, Principal Deputy Assistant Secretary, Office of Energy Efficiency & Renewable Energy on his visit to the L.A. Auto Show in November 2015 Drew Bittner Writer/Editor, Office of Energy Efficiency and Renewable Energy David Friedman, Principal Deputy Assistant

  14. NREL Report Shows Big Potential for the Future of Shared Solar | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy NREL Report Shows Big Potential for the Future of Shared Solar NREL Report Shows Big Potential for the Future of Shared Solar April 28, 2015 - 1:54pm Addthis NREL Report Shows Big Potential for the Future of Shared Solar David Feldman David Feldman Energy Analyst, Department of Energy's National Renewable Energy Laboratory In 2014, the United States brought online as much solar energy every three weeks as it did in all of 2008. Demand for solar electricity is driving this growth in

  15. B&W Y-12 responds to NNSA's show cause letter | Y-12 National...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    responds to ... B&W Y-12 responds to NNSA's show cause letter Posted: September 12, 2012 - 3:29pm On September 10, B&W Y-12 provided its response to the National Nuclear Security...

  16. New Report Shows Domestic Offshore Wind Industry Potential, 21 Projects Planned in U.S. Waters

    Broader source: Energy.gov [DOE]

    The Energy Department today released a new report showing strong progress for the U.S. offshore wind market—including the start of construction of the nation’s first commercial-scale offshore wind...

  17. "Show Preview" button is not working; gives error | OpenEI Community

    Open Energy Info (EERE)

    "Show Preview" button is not working; gives error Home > Groups > Utility Rate Submitted by Ewilson on 3 January, 2013 - 09:52 1 answer Points: 0 Eric, thanks for reporting this. I...

  18. ORISE report shows number of health physics Ph.D.s declined in...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ORISE report shows number of health physics Ph.D.s declined in 2009 FOR IMMEDIATE RELEASE June 15, 2010 FY10-37 OAK RIDGE, Tenn.-Health physics undergraduate degrees increased...

  19. The Consumer Electronics Show round-up | OpenEI Community

    Open Energy Info (EERE)

    The highlights of this year's show were OLED TVs, ultra-thin laptops, tablets, and smartphones. However, a few smart grid-related technologies were making an impression. There...

  20. How Would IBM's Quiz-Show Computer, Watson, Do as a Competitor...

    Office of Science (SC) Website

    How Would IBM's Quiz-Show Computer, Watson, Do as a Competitor in the National Science Bowl? News News Home Featured Articles 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 ...

  1. NETL's 2015 Carbon Storage Atlas Shows Increase in U.S. CO2 Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (Atlas V), which shows prospective carbon dioxide (CO2) storage resources of at least 2,600 billion metric tons - an increase over the findings of the 2012 Atlas. Atlas V is a ...

  2. Thursday: Secretary Moniz to Make Remarks at the Washington Auto Show

    Broader source: Energy.gov [DOE]

    Tomorrow, Energy Secretary Ernest Moniz will attend the Washington Auto Show and make an important announcement about supporting the U.S. clean energy economy and the 21st century automotive industry.

  3. Magnetism reflectometer study shows LiF layers improve efficiency in spin

    Office of Scientific and Technical Information (OSTI)

    valve devices (Journal Article) | SciTech Connect Magnetism reflectometer study shows LiF layers improve efficiency in spin valve devices Citation Details In-Document Search Title: Magnetism reflectometer study shows LiF layers improve efficiency in spin valve devices New, more efficient materials for spin valves - a device used in magnetic sensors, random access memories, and hard disk drives - may be on the way based on research using the magnetism reflectometer at Oak Ridge National

  4. Boron-Nitride Nanotubes Show Potential in Cancer Treatment | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Boron-Nitride Nanotubes Show Potential in Cancer Treatment Boron-Nitride Nanotubes Show Potential in Cancer Treatment NEWPORT NEWS, VA, April 26 - A new study has shown that adding boron-nitride nanotubes to the surface of cancer cells can double the effectiveness of Irreversible Electroporation, a minimally invasive treatment for soft tissue tumors in the liver, lung, prostate, head and neck, kidney and pancreas. Although this research is in the very early stages, it could one day lead to

  5. NREL Shows Heavy Duty Hybrid Trucks Deliver on Fuel Economy - News Releases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | NREL NREL Shows Heavy Duty Hybrid Trucks Deliver on Fuel Economy September 11, 2012 A performance evaluation of Class 8 hybrid electric tractor trailers compared with similar conventional vehicles by the U.S. Department of Energy's (DOE's) National Renewable Energy Laboratory (NREL) shows significant improvements in fuel economy. "During our 13-month study, the hybrid tractors demonstrated 13.7 percent higher fuel economy than the conventional tractors, resulting in a 12 percent

  6. NREL Study Shows 20 Percent Wind is Possible by 2024 - News Releases | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NREL Study Shows 20 Percent Wind is Possible by 2024 Analysis Shows Transmission Upgrades, Offshore Wind, and Operational Changes Needed to Incorporate 20 to 30 Percent Wind January 20, 2010 Today, the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) released the Eastern Wind Integration and Transmission Study (EWITS). This unprecedented two-and-a-half year technical study of future high-penetration wind scenarios was designed to analyze the economic, operational,

  7. NREL Study: Hybrid Delivery Vans Show Nearly 20 Percent Higher Fuel Economy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - News Releases | NREL Study: Hybrid Delivery Vans Show Nearly 20 Percent Higher Fuel Economy September 28, 2012 The U.S. Department of Energy's (DOE)'s National Renewable Energy Laboratory (NREL) recently completed a performance evaluation report that showed significant fuel economy benefits of hybrid electric delivery vans compared to similar conventional vans. "During the on-road portion of our study, the hybrid vans demonstrated a 13 to 20 percent higher fuel economy than the

  8. Top students show off brain power at Kansas City Science Bowl | National

    National Nuclear Security Administration (NNSA)

    Nuclear Security Administration Top students show off brain power at Kansas City Science Bowl Friday, March 20, 2015 - 3:20pm More than 200 students converged in Kansas City recently for the annual Science Bowl Regional Competition to answer questions like, "One-hundredth of a millibar equals how many Pascals?" (The answer is 1). During the many rounds of competition, students showed a remarkable understanding of chemistry, geology, physics, biology, electronics, and more as they

  9. 2014 Data Book Shows Increased Use of Renewable Electricity - News Releases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 DOE Scorecard 2014 DOE Scorecard Office of Management and Budget (OMB) Scorecard reporting Department of Energy sustainability achievements for fiscal year 2014. PDF icon 2014 DOE Scorecard More Documents & Publications Department of Energy FY 2011 OMB Scorecard Department of Energy FY 2012 OMB Scorecard 2013 DOE Scorecard | NREL

    2014 Data Book Shows Increased Use of Renewable Electricity December 9, 2015 The 2014 Renewable Energy Data Book shows that U.S. renewable electricity grew

  10. Three-dimensional local ALE-FEM method for fluid flow in domains containing moving boundaries/objects interfaces

    SciTech Connect (OSTI)

    Carrington, David Bradley; Monayem, A. K. M.; Mazumder, H.; Heinrich, Juan C.

    2015-03-05

    A three-dimensional finite element method for the numerical simulations of fluid flow in domains containing moving rigid objects or boundaries is developed. The method falls into the general category of Arbitrary Lagrangian Eulerian methods; it is based on a fixed mesh that is locally adapted in the immediate vicinity of the moving interfaces and reverts to its original shape once the moving interfaces go past the elements. The moving interfaces are defined by separate sets of marker points so that the global mesh is independent of interface movement and the possibility of mesh entanglement is eliminated. The results is a fully robust formulation capable of calculating on domains of complex geometry with moving boundaries or devises that can also have a complex geometry without danger of the mesh becoming unsuitable due to its continuous deformation thus eliminating the need for repeated re-meshing and interpolation. Moreover, the boundary conditions on the interfaces are imposed exactly. This work is intended to support the internal combustion engines simulator KIVA developed at Los Alamos National Laboratories. The model's capabilities are illustrated through application to incompressible flows in different geometrical settings that show the robustness and flexibility of the technique to perform simulations involving moving boundaries in a three-dimensional domain.

  11. Unstable domains of tearing and Kelvin-Helmholtz instabilities in a rotating cylindrical plasma

    SciTech Connect (OSTI)

    Fan, D. M.; Wei, L.; Wang, Z. X. Zheng, S.; Duan, P.

    2014-09-15

    Effects of poloidal rotation profile on tearing and Kelvin-Helmholtz (KH) instabilities in a cylindrical plasma are investigated by using a reduced magnetohydrodynamic model. Since the poloidal rotation has different effects on the tearing and KH modes in different rotation regimes, four unstable domains are numerically identified, i.e., the destabilized tearing mode domain, stabilized tearing mode domain, stable-window domain, and unstable KH mode domain. It is also found that when the rotation layer is in the outer region of the rational surface, the stabilizing role of the rotation can be enhanced so significantly that the stable window domain is enlarged. Moreover, Alfvén resonances can be induced by the tearing and KH modes in such rotating plasmas. Radially wide profiles of current and vorticity perturbations can be formed when multiple current sheets on different resonance positions are coupled together.

  12. System and method for manipulating domain pinning and reversal in ferromagnetic materials

    DOE Patents [OSTI]

    Silevitch, Daniel M.; Rosenbaum, Thomas F.; Aeppli, Gabriel

    2013-10-15

    A method for manipulating domain pinning and reversal in a ferromagnetic material comprises applying an external magnetic field to a uniaxial ferromagnetic material comprising a plurality of magnetic domains, where each domain has an easy axis oriented along a predetermined direction. The external magnetic field is applied transverse to the predetermined direction and at a predetermined temperature. The strength of the magnetic field is varied at the predetermined temperature, thereby isothermally regulating pinning of the domains. A magnetic storage device for controlling domain dynamics includes a magnetic hard disk comprising a uniaxial ferromagnetic material, a magnetic recording head including a first magnet, and a second magnet. The ferromagnetic material includes a plurality of magnetic domains each having an easy axis oriented along a predetermined direction. The second magnet is positioned adjacent to the magnetic hard disk and is configured to apply a magnetic field transverse to the predetermined direction.

  13. Holographic imaging based on time-domain data of natural-fiber-containing materials

    DOE Patents [OSTI]

    Bunch, Kyle J.; McMakin, Douglas L.

    2012-09-04

    Methods and apparatuses for imaging material properties in natural-fiber-containing materials can utilize time-domain data. In particular, images can be constructed that provide quantified measures of localized moisture content. For example, one or more antennas and at least one transceiver can be configured to collect time-domain data from radiation interacting with the natural-fiber-containing materials. The antennas and the transceivers are configured to transmit and receive electromagnetic radiation at one or more frequencies, which are between 50 MHz and 1 THz, according to a time-domain impulse function. A computing device is configured to transform the time-domain data to frequency-domain data, to apply a synthetic imaging algorithm for constructing a three-dimensional image of the natural-fiber-containing materials, and to provide a quantified measure of localized moisture content based on a pre-determined correlation of moisture content to frequency-domain data.

  14. Cummins Case Study Shows a 12.6% Improvement in Energy Performance with SEP

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy Cummins Case Study Shows a 12.6% Improvement in Energy Performance with SEP Cummins Case Study Shows a 12.6% Improvement in Energy Performance with SEP August 6, 2015 - 11:38am Addthis A recently published case study examines the successes of Cummins Inc., a global engine manufacturer that implemented an energy management system (EnMS) that meets the requirements of ISO 50001 and Superior Energy Performance® (SEP(tm)). Cummins implemented the EnMS at the Rocky Mount

  15. ORISE report shows number of health physics Ph.D.s declined in 2009

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ORISE report shows number of health physics Ph.D.s declined in 2009 FOR IMMEDIATE RELEASE June 15, 2010 FY10-37 OAK RIDGE, Tenn.-Health physics undergraduate degrees increased slightly in 2009 continuing a six-year trend, but doctorate degrees reported a 40-year low, says a report recently released by the Oak Ridge Institute for Science and Education. The report also showed the number of M.S. degrees was 21 percent less than in 2008. The ORISE report, Health Physics Enrollments and Degrees

  16. Annual report shows potential INL radiation dose well below safe regulatory

    Energy Savers [EERE]

    limits | Department of Energy Annual report shows potential INL radiation dose well below safe regulatory limits Annual report shows potential INL radiation dose well below safe regulatory limits August 9, 2011 - 12:00pm Addthis Media Contact Tim Jackson, DOE-Idaho Operations Office 208-526-8484 The U.S. Department of Energy's Idaho Operations Office reported this month that radiation from the site falls well below limits established by the U.S. Environmental Protection Agency. The annual

  17. New Carbon Storage Atlas Shows Hundreds of Years of CO2 Storage Potential |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Carbon Storage Atlas Shows Hundreds of Years of CO2 Storage Potential New Carbon Storage Atlas Shows Hundreds of Years of CO2 Storage Potential December 21, 2012 - 9:58am Addthis Atlas IV was created by the National Energy Technology Laboratory (NETL), and includes input from the more than 400 organizations in 43 states and four Canadian provinces that make up the Department’s seven Regional Carbon Sequestration Partnerships (as shown above). <a

  18. Sour Gas Streams Safe for Carbon Sequestration, DOE-Sponsored Study Shows |

    Energy Savers [EERE]

    Department of Energy Sour Gas Streams Safe for Carbon Sequestration, DOE-Sponsored Study Shows Sour Gas Streams Safe for Carbon Sequestration, DOE-Sponsored Study Shows September 23, 2010 - 1:00pm Addthis Washington, D.C. -- Gas streams containing high levels of both carbon dioxide (CO2) and hydrogen sulfide (H2S) can be safely used for carbon capture and storage (CCS), according to results from a field test completed by the Plains CO2 Reduction (PCOR) Partnership. The test by PCOR--one of

  19. Crystal structure of the N-terminal region of human Ash2L shows a

    Office of Scientific and Technical Information (OSTI)

    winged-helix motif involved in DNA binding (Journal Article) | SciTech Connect Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding Citation Details In-Document Search Title: Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding Ash2L is a core component of the MLL family histone methyltransferases and has an important role in regulating the methylation of histone H3 on lysine 4.

  20. New Interactive Map Shows Big Potential for America's Wind Energy Future

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy Interactive Map Shows Big Potential for America's Wind Energy Future New Interactive Map Shows Big Potential for America's Wind Energy Future March 31, 2015 - 11:50am Addthis Wind Vision See the projected growth of the wind industry over the next 35 years. Select a Year 2000 2010 2013 2020 2030 2050 All units are in gigawatts (GW). Only states with total capacity over 0.1 GW are included per year. Find out more about the data by reading the Wind Vision Report. You can

  1. Periplasmic Domains of Pseudomonas aeruginosa PilN and PilO Form a Stable Heterodimeric Complex

    SciTech Connect (OSTI)

    Sampaleanu, L.M.; Bonanno, J.B.; Ayers, M.; Koo, J.; Tammam, S.; Burley, S.K.; Almo, S.C.; Burrows, L.L.; Howell, P.L.

    2010-01-12

    Type IV pili (T4P) are bacterial virulence factors responsible for attachment to surfaces and for twitching motility, a motion that involves a succession of pilus extension and retraction cycles. In the opportunistic pathogen Pseudomonas aeruginosa, the PilM/N/O/P proteins are essential for T4P biogenesis, and genetic and biochemical analyses strongly suggest that they form an inner-membrane complex. Here, we show through co-expression and biochemical analysis that the periplasmic domains of PilN and PilO interact to form a heterodimer. The structure of residues 69-201 of the periplasmic domain of PilO was determined to 2.2 {angstrom} resolution and reveals the presence of a homodimer in the asymmetric unit. Each monomer consists of two N-terminal coiled coils and a C-terminal ferredoxin-like domain. This structure was used to generate homology models of PilN and the PilN/O heterodimer. Our structural analysis suggests that in vivo PilN/O heterodimerization would require changes in the orientation of the first N-terminal coiled coil, which leads to two alternative models for the role of the transmembrane domains in the PilN/O interaction. Analysis of PilN/O orthologues in the type II secretion system EpsL/M revealed significant similarities in their secondary structures and the tertiary structures of PilO and EpsM, although the way these proteins interact to form inner-membrane complexes appears to be different in T4P and type II secretion. Our analysis suggests that PilN interacts directly, via its N-terminal tail, with the cytoplasmic protein PilM. This work shows a direct interaction between the periplasmic domains of PilN and PilO, with PilO playing a key role in the proper folding of PilN. Our results suggest that PilN/O heterodimers form the foundation of the inner-membrane PilM/N/O/P complex, which is critical for the assembly of a functional T4P complex.

  2. Experimental measurement of stress at a four-domain junction in lead

    Office of Scientific and Technical Information (OSTI)

    zirconate titanate (Journal Article) | SciTech Connect Experimental measurement of stress at a four-domain junction in lead zirconate titanate Citation Details In-Document Search Title: Experimental measurement of stress at a four-domain junction in lead zirconate titanate A junction between two lamellar bands of ferroelectric domains in a lead zirconate titanate ceramic is analyzed using Kikuchi diffraction patterns in the transmission electron microscope. Indexing of the diffraction

  3. The Importance of Domain Size and Purity in High-Efficiency Organic Solar

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cells The Importance of Domain Size and Purity in High-Efficiency Organic Solar Cells Print The efficiency of polymer/organic photovoltaic cells hinges on excitons-electron/hole pairs energized by sunlight-getting to the interfaces of donor and acceptor domains quickly, before recombining. At the interfaces, they become free charges that must then reach device electrodes. With the discovery of mixed domains of donor and acceptor molecules, many have pictured the excitons' journey as easy

  4. The Importance of Domain Size and Purity in High-Efficiency Organic Solar

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cells The Importance of Domain Size and Purity in High-Efficiency Organic Solar Cells Print The efficiency of polymer/organic photovoltaic cells hinges on excitons-electron/hole pairs energized by sunlight-getting to the interfaces of donor and acceptor domains quickly, before recombining. At the interfaces, they become free charges that must then reach device electrodes. With the discovery of mixed domains of donor and acceptor molecules, many have pictured the excitons' journey as easy

  5. The Importance of Domain Size and Purity in High-Efficiency Organic Solar

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cells The Importance of Domain Size and Purity in High-Efficiency Organic Solar Cells Print The efficiency of polymer/organic photovoltaic cells hinges on excitons-electron/hole pairs energized by sunlight-getting to the interfaces of donor and acceptor domains quickly, before recombining. At the interfaces, they become free charges that must then reach device electrodes. With the discovery of mixed domains of donor and acceptor molecules, many have pictured the excitons' journey as easy

  6. The Importance of Domain Size and Purity in High-Efficiency Organic Solar

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cells The Importance of Domain Size and Purity in High-Efficiency Organic Solar Cells Print The efficiency of polymer/organic photovoltaic cells hinges on excitons-electron/hole pairs energized by sunlight-getting to the interfaces of donor and acceptor domains quickly, before recombining. At the interfaces, they become free charges that must then reach device electrodes. With the discovery of mixed domains of donor and acceptor molecules, many have pictured the excitons' journey as easy

  7. Modeling of leachate generation from MSW landfills by a 2-dimensional 2-domain approach

    SciTech Connect (OSTI)

    Fellner, Johann

    2010-11-15

    The flow of water through Municipal Solid Waste (MSW) landfills is highly non-uniform and dominated by preferential pathways. Thus, concepts to simulate landfill behavior require that a heterogeneous flow regime is considered. Recent models are based on a 2-domain approach, differentiating between channel domain with high hydraulic conductivity, and matrix domain of slow water movement with high water retention capacity. These models focus on the mathematical description of rapid water flow in channel domain. The present paper highlights the importance of water exchange between the two domains, and expands the 1-dimensional, 2-domain flow model by taking into account water flows in two dimensions. A flow field consisting of a vertical path (channel domain) surrounded by the waste mass (matrix domain) is defined using the software HYDRUS-2D. When the new model is calibrated using data sets from a MSW-landfill site the predicted leachate generation corresponds well with the observed leachate discharge. An overall model efficiency in terms of r{sup 2} of 0.76 was determined for a simulation period of almost 4 years. The results confirm that water in landfills follows a preferential path way characterized by high permeability (K{sub s} = 300 m/d) and zero retention capacity, while the bulk of the landfill (matrix domain) is characterized by low permeability (K{sub s} = 0.1 m/d) and high retention capacity. The most sensitive parameters of the model are the hydraulic conductivities of the channel domain and the matrix domain, and the anisotropy of the matrix domain.

  8. The Importance of Domain Size and Purity in High-Efficiency Organic Solar

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cells The Importance of Domain Size and Purity in High-Efficiency Organic Solar Cells Print The efficiency of polymer/organic photovoltaic cells hinges on excitons-electron/hole pairs energized by sunlight-getting to the interfaces of donor and acceptor domains quickly, before recombining. At the interfaces, they become free charges that must then reach device electrodes. With the discovery of mixed domains of donor and acceptor molecules, many have pictured the excitons' journey as easy

  9. The Importance of Domain Size and Purity in High-Efficiency Organic Solar

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cells The Importance of Domain Size and Purity in High-Efficiency Organic Solar Cells Print The efficiency of polymer/organic photovoltaic cells hinges on excitons-electron/hole pairs energized by sunlight-getting to the interfaces of donor and acceptor domains quickly, before recombining. At the interfaces, they become free charges that must then reach device electrodes. With the discovery of mixed domains of donor and acceptor molecules, many have pictured the excitons' journey as easy

  10. The Importance of Domain Size and Purity in High-Efficiency Organic Solar

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cells The Importance of Domain Size and Purity in High-Efficiency Organic Solar Cells Print The efficiency of polymer/organic photovoltaic cells hinges on excitons-electron/hole pairs energized by sunlight-getting to the interfaces of donor and acceptor domains quickly, before recombining. At the interfaces, they become free charges that must then reach device electrodes. With the discovery of mixed domains of donor and acceptor molecules, many have pictured the excitons' journey as easy

  11. TU-F-18A-02: Iterative Image-Domain Decomposition for Dual-Energy CT

    SciTech Connect (OSTI)

    Niu, T; Dong, X; Petrongolo, M; Zhu, L

    2014-06-15

    Purpose: Dual energy CT (DECT) imaging plays an important role in advanced imaging applications due to its material decomposition capability. Direct decomposition via matrix inversion suffers from significant degradation of image signal-to-noise ratios, which reduces clinical value. Existing de-noising algorithms achieve suboptimal performance since they suppress image noise either before or after the decomposition and do not fully explore the noise statistical properties of the decomposition process. We propose an iterative image-domain decomposition method for noise suppression in DECT, using the full variance-covariance matrix of the decomposed images. Methods: The proposed algorithm is formulated in the form of least-square estimation with smoothness regularization. It includes the inverse of the estimated variance-covariance matrix of the decomposed images as the penalty weight in the least-square term. Performance is evaluated using an evaluation phantom (Catphan 600) and an anthropomorphic head phantom. Results are compared to those generated using direct matrix inversion with no noise suppression, a de-noising method applied on the decomposed images, and an existing algorithm with similar formulation but with an edge-preserving regularization term. Results: On the Catphan phantom, our method retains the same spatial resolution as the CT images before decomposition while reducing the noise standard deviation of decomposed images by over 98%. The other methods either degrade spatial resolution or achieve less low-contrast detectability. Also, our method yields lower electron density measurement error than direct matrix inversion and reduces error variation by over 97%. On the head phantom, it reduces the noise standard deviation of decomposed images by over 97% without blurring the sinus structures. Conclusion: We propose an iterative image-domain decomposition method for DECT. The method combines noise suppression and material decomposition into an iterative process and achieves both goals simultaneously. The proposed algorithm shows superior performance on noise suppression with high image spatial resolution and low-contrast detectability. This work is supported by a Varian MRA grant.

  12. TU-C-17A-05: Dose Domain Optimization of MLC Leaf Patterns for...

    Office of Scientific and Technical Information (OSTI)

    domain required multiplying the fluence with a sparse matrix. Exploiting this property made it feasible to solve the problem using CVX, a MATLAB-based convex modeling framework. ...

  13. Polarization reversal and domain kinetics in magnesium doped stoichiometric lithium tantalate

    SciTech Connect (OSTI)

    Shur, V. Ya., E-mail: vladimir.shur@urfu.ru; Akhmatkhanov, A. R.; Baturin, I. S. [Institute of Natural Sciences, Ural Federal University, 620000 Ekaterinburg (Russian Federation); Labfer Ltd., 620014 Ekaterinburg (Russian Federation); Chuvakova, M. A. [Institute of Natural Sciences, Ural Federal University, 620000 Ekaterinburg (Russian Federation)

    2014-10-13

    The polarization reversal process has been studied in 1?mol.?% MgO doped stoichiometric lithium tantalate (LT) single crystal. The revealed stages of domain structure evolution represent (1) continuous nucleation and growth of isolated hexagonal domains with walls oriented along Y directions and (2) continuous motion of the plane domain walls stimulated by merging with isolated domains. The activation field dependence of the switching time has been revealed. The coercive field for quasi-static switching is about 150?V/mm. The bulk screening process has been analyzed. The main parameters of the switching process have been compared with other representatives of LT family.

  14. Time-resolved observation of fast domain-walls driven by vertical spin currents in short tracks

    SciTech Connect (OSTI)

    Sampaio, Joao; Lequeux, Steven; Chanthbouala, Andre; Cros, Vincent; Grollier, Julie; Matsumoto, Rie; Yakushiji, Kay; Kubota, Hitoshi; Fukushima, Akio; Yuasa, Shinji; Nishimura, Kazumasa; Nagamine, Yoshinori; Maehara, Hiroki; Tsunekawa, Koji

    2013-12-09

    We present time-resolved measurements of the displacement of magnetic domain-walls (DWs) driven by vertical spin-polarized currents in track-shaped magnetic tunnel junctions. In these structures, we observe very high DW velocities (600 m/s) at current densities below 10{sup 7} A/cm{sup 2}. We show that the efficient spin-transfer torque combined with a short propagation distance allows avoiding the Walker breakdown process and achieving deterministic, reversible, and fast (≈1 ns) DW-mediated switching of magnetic tunnel junction elements, which is of great interest for the implementation of fast DW-based spintronic devices.

  15. Magnetic bead detection using domain wall-based nanosensor

    SciTech Connect (OSTI)

    Corte-León, H.; Krzysteczko, P.; Schumacher, H. W.; Manzin, A.; Cox, D.; Antonov, V.; Kazakova, O.

    2015-05-07

    We investigate the effect of a single magnetic bead (MB) on the domain wall (DW) pinning/depinning fields of a DW trapped at the corner of an L-shaped magnetic nanodevice. DW propagation across the device is investigated using magnetoresistance measurements. DW pinning/depinning fields are characterized in as-prepared devices and after placement of a 1 μm-sized MB (Dynabeads{sup ®} MyOne{sup ™}) at the corner. The effect of the MB on the DW dynamics is seen as an increase in the depinning field for specific orientations of the device with respect to the external magnetic field. The shift of the depinning field, ΔB{sub dep} = 4.5–27.0 mT, is highly stable and reproducible, being significantly above the stochastic deviation which is about 0.5 mT. The shift in the deppinning field is inversely proportional to the device width and larger for small negative angles between the device and the external magnetic field. Thus, we demonstrate that DW-based devices can be successfully used for detection of single micron size MB.

  16. Time domain reflectometry development for use in geotechnical engineering

    SciTech Connect (OSTI)

    Siddiqui, S.I.; Drnevich, V.P.; Deschamps, R.J.

    2000-03-01

    This study extends the use of time domain reflectometry (TDR) in geotechnical engineering, a technique originally developed to locate faults in transmission lines. Different elements of the TDR technique are developed, including design of TDR probes, probe installation/test methodology, and relationships between TDR measured dielectric constant and water content of soil. A coaxial probe is developed that is used for measuring the dielectric constant of soil prepared in a cylindrical cell or compaction mold. A multiple-rod field probe is developed that modifies previously developed multiple-rod probes and extends their capability for measuring the in-place dielectric constant of soil. An analytical solution is developed to determine the sampling volume and spatial bias of the TDR measurement. The solution is extended to study the effect of soil disturbance and presence of air gaps due to probe insertion. Experimental results validate the solutions. New relationships are proposed between dielectric constant and water content to eliminate some of the limitations of the existing calibration relationships. Several possible applications of the developed probes, test methodology, and calibration equations for measuring water content and density of soil are illustrated.

  17. An Analog Filter Approach to Frequency Domain Fluorescence Spectroscopy

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Trainham, Clifford P.; O'Neill, Mary D.; McKenna, Ian J.

    2015-04-24

    The rate equations found in frequency domain fluorescence spectroscopy are the same as those found in electronics under analog filter theory. Laplace transform methods are a natural way to solve the equations, and the methods can provide solutions for arbitrary excitation functions. The fluorescence terms can be modeled as circuit components and cascaded with drive and detection electronics to produce a global transfer function. Electronics design tools such as Spicea can be used to model fluorescence problems. In applications, such as remote sensing, where detection electronics are operated at high gain and limited bandwidth, a global modeling of the entiremore » system is important, since the filter terms of the drive and detection electronics affect the measured response of the fluorescence signals. The techniques described here can be used to separate signals from fast and slow fluorophores emitting into the same spectral band, and data collection can be greatly accelerated by means of a frequency comb driver waveform and appropriate signal processing of the response.« less

  18. THz time-domain spectroscopy for tokamak plasma diagnostics

    SciTech Connect (OSTI)

    Causa, F.; Zerbini, M.; Buratti, P.; Gabellieri, L.; Pacella, D.; Romano, A.; Tuccillo, A. A.; Tudisco, O.; Johnston, M.; Doria, A.; Gallerano, G. P.; Giovenale, E.

    2014-08-21

    The technology is now becoming mature for diagnostics using large portions of the electromagnetic spectrum simultaneously, in the form of THz pulses. THz radiation-based techniques have become feasible for a variety of applications, e.g., spectroscopy, imaging for security, medicine and pharmaceutical industry. In particular, time-domain spectroscopy (TDS) is now being used also for plasma diagnostics in various fields of application. This technique is promising also for plasmas for fusion applications, where plasma characteristics are non-uniform and/or evolve during the discharge This is because THz pulses produced with femtosecond mode-locked lasers conveniently span the spectrum above and below the plasma frequency and, thus, can be used as very sensitive and versatile probes of widely varying plasma parameters. The short pulse duration permits time resolving plasma characteristics while the large frequency span permits a large dynamic range. The focus of this work is to present preliminary experimental and simulation results demonstrating that THz TDS can be realistically adapted as a versatile tokamak plasma diagnostic technique.

  19. An Analog Filter Approach to Frequency Domain Fluorescence Spectroscopy

    SciTech Connect (OSTI)

    Trainham, Clifford P.; O'Neill, Mary D.; McKenna, Ian J.

    2015-04-24

    The rate equations found in frequency domain fluorescence spectroscopy are the same as those found in electronics under analog filter theory. Laplace transform methods are a natural way to solve the equations, and the methods can provide solutions for arbitrary excitation functions. The fluorescence terms can be modeled as circuit components and cascaded with drive and detection electronics to produce a global transfer function. Electronics design tools such as Spicea can be used to model fluorescence problems. In applications, such as remote sensing, where detection electronics are operated at high gain and limited bandwidth, a global modeling of the entire system is important, since the filter terms of the drive and detection electronics affect the measured response of the fluorescence signals. The techniques described here can be used to separate signals from fast and slow fluorophores emitting into the same spectral band, and data collection can be greatly accelerated by means of a frequency comb driver waveform and appropriate signal processing of the response.

  20. In-Situ Liquid (ec)-TEM Cell Shows Dendrite Formation, Providing New

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insights into Lithium Batteries - Joint Center for Energy Storage Research March 3, 2014, Research Highlights In-Situ Liquid (ec)-TEM Cell Shows Dendrite Formation, Providing New Insights into Lithium Batteries (Top) In-situ liquid electrochemical (ec)-TEM cell uses two silicon microchips to create a three-electrode electrochemical cell with silicon nitride membranes that seal battery electrolytes. This enables charge/discharge cycling of the battery inside the high vacuum of a transmission

  1. ORISE: Report shows nuclear engineering graduation rates on the rise in

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2013 ORISE report shows nuclear engineering graduation rates on the rise in 2013 Number of graduate degrees expected to remain consistent, but undergraduate degrees could see decrease come 2015 FOR IMMEDIATE RELEASE March 3, 2014 FY14-11 OAK RIDGE, Tenn.-The number of college students graduating with majors in nuclear engineering continues to increase, according to a report by the Oak Ridge Institute for Science and Education, which surveyed 32 U.S. universities with nuclear engineering

  2. NREL: News - Expo to Show Consumers How to Cut Energy Use

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Expo to Show Consumers How to Cut Energy Use Golden, Colo., June 6, 2002 Consumers can learn how to save energy and money at home from experts who specialize in energy efficient and renewable energy products and services at the Consumer Energy Expo June 21 - 22. The Expo is hosted by the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) in conjunction with Colorado Energy Science Center (CESC). The Expo at NREL's Visitors Center includes exhibits and activities for the

  3. Natural Gas Issues and Trends - High prices show stresses in New England

    U.S. Energy Information Administration (EIA) Indexed Site

    natural gas delivery system - Energy Information Administration High prices show stresses in New England natural gas delivery system Released: February 7, 2014 Abstract. Since 2012, limited supply from the Canaport and Everett liquefied natural gas (LNG) terminals coupled with congestion on the Tennessee and Algonquin pipelines has led to winter natural gas price spikes in New England. The problem continued in the winter of 2013-14, as indicated by New England's forward basis for January

  4. NREL Study Shows Renewable Energy Potential in Every State - News Releases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | NREL NREL Study Shows Renewable Energy Potential in Every State U.S. RE Technical Potential study produces estimates across technologies July 26, 2012 A new study of renewable energy's technical potential finds that every state in the nation has the space and resource to generate clean energy. The U.S. Department of Energy's National Renewable Energy Laboratory produced the study, U.S. RE Technical Potential, which looks at available renewable resources in each state. It establishes an

  5. NREL report shows E85 gives gas stations a competitive edge - News Releases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | NREL report shows E85 gives gas stations a competitive edge Quantity of E85 sold most important factor in profitability July 18, 2008 A study released by the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) can help gas station owners and Clean Cities stakeholders determine whether adding E85 to their product mix can increase profitability. Competition in the fueling station business continues to intensify, particularly as grocery stores and discount clubs

  6. CRF: First Direct Detection of QOOH Intermediate Shows Long Lifetime of Key

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Species CRF: First Direct Detection of QOOH Intermediate Shows Long Lifetime of Key Species - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization

  7. Microalgae Shows High-Energy Potential as a U.S. Biofuel - News Releases |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NREL Microalgae Shows High-Energy Potential as a U.S. Biofuel AAAS Speakers to Detail Latest Microalgae Developments on February 19 February 17, 2010 Dr. Al Darzins, Principal Group Manager at the U.S. Department of Energy's National Renewable Energy Laboratory (NREL), will discuss how NREL is advancing the development of microalgae as a renewable biofuel on Feb. 19 at the AAAS Annual Meeting in San Diego. NREL researchers currently are accelerating efforts to identify and characterize the

  8. Customizable Interactive Map Shows U.S. Alternative Fuel Data - News

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Releases | NREL Customizable Interactive Map Shows U.S. Alternative Fuel Data Users can find fuel stations, vehicle concentrations, and production plants June 9, 2009 The U.S. Department of Energy (DOE) and the National Renewable Energy Lab (NREL) announced the launch of a comprehensive mapping tool to help industry and government planners implement alternative fuels and advanced vehicles. The new TransAtlas tool combines several different types of geographic data to identify areas with

  9. Pantex-Y-12 resource-sharing shows the benefit of consolidation | National

    National Nuclear Security Administration (NNSA)

    Nuclear Security Administration Pantex-Y-12 resource-sharing shows the benefit of consolidation Wednesday, March 9, 2016 - 4:51pm Y 12 engineers Tucker Fritz, Sarah Cruise and Damita Mason (seated) accepted temporary assignments at Pantex. Shown with them are Pantex Engineering Manager Joe Papp and CNS Vice President of Engineering Mike Beck. Three Y-12 employees recently completed temporary assignments at Pantex. Y-12 engineers Sarah Cruise, Tucker Fritz and Damita Mason spent three months

  10. In situ measurement of increased ferroelectric/ferroelastic domain...

    Office of Scientific and Technical Information (OSTI)

    S. 1 + Show Author Affiliations Department of Materials Science and Engineering and Materials Research Institute, The Pennsylvania State University, University Park, ...

  11. Crystal structure of a ;#8203;BRAF kinase domain monomer explains...

    Office of Scientific and Technical Information (OSTI)

    2 + Show Author Affiliations (Mount Sinai Hospital) ( Publication Date: 2015-09-18 OSTI Identifier: 1194215 Resource Type: Journal Article Resource Relation: Journal Name: Nat. ...

  12. Structure of Protein Having Inhibitory Disintegrin and Leukotriene Scavenging Functions Contained in Single Domain

    SciTech Connect (OSTI)

    Xu, Xueqing; Francischetti, Ivo M.B.; Lai, Ren; Ribeiro, Jos M.C.; Andersen, John F.

    2012-08-10

    The antihemostatic/antiangiogenic protein tablysin-15 is a member of the CAP (cysteine-rich secretory, antigen 5, and pathogenesis-related 1 protein) superfamily and has been shown to bind the integrins {alpha}{sub IIb}{beta}{sub 3} and {alpha}{sub V}{beta}{sub 3} by means of an Arg-Gly-Asp (RGD) tripeptide sequence. Here we describe the x-ray crystal structure of tablysin-15 and show that the RGD motif is located in a novel structural context. The motif itself is contained in a type II {beta}-turn structure that is similar in its conformation to the RGD sequence of the cyclic pentapeptide cilengitide when bound to integrin {alpha}V{beta}3. The CAP domain also contains a hydrophobic channel that appears to bind a fatty acid molecule in the crystal structure after purification from Escherichia coli. After delipidation of the protein, tablysin-15 was found to bind proinflammatory cysteinyl leukotrienes with submicromolar affinities. The structure of the leukotriene E{sub 4}-tablysin-15 complex shows that the ligand binds with the nonfunctionalized end of the fatty acid chain buried in the hydrophobic pocket, whereas the carboxylate end of the ligand binds forms hydrogen bond/salt bridge interactions with polar side chains at the channel entrance. Therefore, tablysin-15 functions as an inhibitor of integrin function and as an anti-inflammatory scavenger of eicosanoids.

  13. NREL Survey Shows Dramatic Improvement in B100 Biodiesel Quality - News

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Releases | NREL Survey Shows Dramatic Improvement in B100 Biodiesel Quality April 15, 2013 The latest national survey of 100% biodiesel (B100) "blend stock" samples by the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) found that 95% of the samples from 2011-12 met ASTM International fuel quality specifications. The ASTM standards serve as guidelines for industry and are designed to ensure quality at the pump for consumers - along with reliable operation of

  14. KCP shows off the fun side of science | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    Administration KCP shows off the fun side of science Friday, May 9, 2014 - 3:23pm From liquid nitrogen to the 3D simulation room, students were immersed in hands-on science fun at this year's Take Your Child To Work Day at the Kansas City Plant. "We are proud of the work we do, and we welcome any opportunity to share the story of our mission." said Mark Holecek, Kansas City Field Office Manager. "As a parent, I think it is even more important that we share our scientific and

  15. BnNHL18A shows a localization change by stress-inducing chemical treatments

    SciTech Connect (OSTI)

    Lee, Suk-Bae; Ham, Byung-Kook; Park, Jeong Mee; Kim, Young Jin; Paek, Kyung-Hee . E-mail: khpaek95@korea.ac.kr

    2006-01-06

    The two genes, named BnNHL18A and BnNHL18B, showing sequence homology with Arabidopsis NDR1/HIN1-like (NHL) genes, were isolated from cDNA library prepared with oilseed rape (Brassica napus) seedlings treated with NaCl. The transcript level of BnNHL18A was increased by sodium chloride, ethephon, hydrogen peroxide, methyl jasmonate, or salicylic acid treatment. The coding regions of BnNHL18A and BnNHL18B contain a sarcolipin (SLN)-like sequence. Analysis of the localization of smGFP fusion proteins showed that BnNHL18A is mainly localized to endoplasmic reticulum (ER). This result suggests that the SLN-like sequence plays a role in retaining proteins in ER membrane in plants. In response to NaCl, hydrogen peroxide, ethephon, and salicylic acid treatments, the protein localization of BnNHL18A was changed. Our findings suggest a common function of BnNHL18A in biotic and abiotic stresses, and demonstrate the presence of the shared mechanism of protein translocalization between the responses to plant pathogen and to osmotic stress.

  16. Magnetic thin-film split-domain current sensor-recorder

    DOE Patents [OSTI]

    Hsieh, Edmund J.

    1979-01-01

    A sensor-recorder for recording a representation of the direction and peak amplitude of a transient current. A magnetic thin film is coated on a glass substrate under the influence of a magnetic field so that the finished film is magnetically uniaxial and anisotropic. The film is split into two oppositely magnetized contiguous domains with a central boundary by subjecting adjacent portions of the film simultaneously to magnetic fields that are opposed 180.degree.. With the split-domain sensor-recorder placed with the film plane and domain boundary either perpendicular or parallel to the expected conductive path of a transient current, the occurrence of the transient causes switching of a portion of one domain to the direction of the other domain. The amount of the switched domain portion is indicative of the amplitude of the peak current of the transient, while the particular domain that is switched is indicative of the direction of the current. The resulting domain patterns may be read with a passive magnetic tape viewer.

  17. Self-annihilation of inversion domains by high energy defects in III-Nitrides

    SciTech Connect (OSTI)

    Koukoula, T.; Kioseoglou, J. Kehagias, Th.; Komninou, Ph.; Ajagunna, A. O.; Georgakilas, A.

    2014-04-07

    Low-defect density InN films were grown on Si(111) by molecular beam epitaxy over an ?1??m thick GaN/AlN buffer/nucleation layer. Electron microscopy observations revealed the presence of inverse polarity domains propagating across the GaN layer and terminating at the sharp GaN/InN (0001{sup }) interface, whereas no inversion domains were detected in InN. The systematic annihilation of GaN inversion domains at the GaN/InN interface is explained in terms of indium incorporation on the Ga-terminated inversion domains forming a metal bonded In-Ga bilayer, a structural instability known as the basal inversion domain boundary, during the initial stages of InN growth on GaN.

  18. Fibroblasts maintained in 3 dimensions show a better differentiation state and higher sensitivity to estrogens

    SciTech Connect (OSTI)

    Montani, Claudia; Steimberg, Nathalie; Boniotti, Jennifer; Biasiotto, Giorgio; Zanella, Isabella; Diafera, Giuseppe; Biunno, Ida; Caimi, Luigi; Mazzoleni, Giovanna; Di Lorenzo, Diego

    2014-11-01

    Cell differentiation and response to hormonal signals were studied in a 3D environment on an in-house generated mouse fibroblast cell line expressing a reporter gene under the control of estrogen responsive sequences (EREs). 3D cell culture conditions were obtained in a Rotary Cell Culture System; (RCCS™), a microgravity based bioreactor that promotes the aggregation of cells into multicellular spheroids (MCS). In this bioreactor the cells maintained a better differentiated phenotype and more closely resembled in vivo tissue. The RCCS™ cultured fibroblasts showed higher expression of genes regulating cell assembly, differentiation and hormonal functions. Microarray analysis showed that genes related to cell cycle, proliferation, cytoskeleton, migration, adhesion and motility were all down-regulated in 3D as compared to 2D conditions, as well as oncogene expression and inflammatory cytokines. Controlled remodeling of ECM, which is an essential aspect of cell organization, homeostasis and tissue was affected by the culture method as assessed by immunolocalization of β-tubulin. Markers of cell organization, homeostasis and tissue repair, metalloproteinase 2 (MMP2) and its physiological inhibitor (TIMP4) changed expression in association with the relative formation of cell aggregates. The fibroblasts cultured in the RCCS™ maintain a better responsiveness to estrogens, measured as expression of ERα and regulation of an ERE-dependent reporter and of the endogenous target genes CBP, Rarb, MMP1 and Dbp. Our data highlight the interest of this 3D culture model for its potential application in the field of cell response to hormonal signals and the pharmaco-toxicological analyses of chemicals and natural molecules endowed of estrogenic potential. - Highlights: • We here characterized the first cell line derived from an estrogen reporter mouse. • In the RCCS cells express an immortalized behavior but not a transformed phenotype. • The RCCS provides a system for maintaining cells in more physiological conditions. • RCCS-cultured fibroblasts showed higher hormonal sensitivity to estradiol. • This bioreactor is a novel 3D model to be applied to pharmacotoxicological studies.

  19. Lithium inclusion in indium metal-organic frameworks showing increased surface area and hydrogen adsorption

    SciTech Connect (OSTI)

    Bosch, Mathieu; Zhang, Muwei; Feng, Dawei; Yuan, Shuai; Wang, Xuan; Chen, Ying-Pin; Zhou, Hong-Cai

    2014-12-01

    Investigation of counterion exchange in two anionic In-Metal-Organic Frameworks (In-MOFs) showed that partial replacement of disordered ammonium cations was achieved through the pre-synthetic addition of LiOH to the reaction mixture. This resulted in a surface area increase of over 1600% in (Li [In(1,3 − BDC){sub 2}]){sub n} and enhancement of the H{sub 2} uptake of approximately 275% at 80 000 Pa at 77 K. This method resulted in frameworks with permanent lithium content after repeated solvent exchange as confirmed by inductively coupled plasma mass spectrometry. Lithium counterion replacement appears to increase porosity after activation through replacement of bulkier, softer counterions and demonstrates tuning of pore size and properties in MOFs.

  20. Configuration of ripple domains and their topological defects...

    Office of Scientific and Technical Information (OSTI)

    materials. Authors: Park, Yeonggu 1 ; Choi, Jin Sik 2 ; Choi, Taekjib 3 ; Lee, Mi Jung 1 ; Jia, Quanxi 4 ; Park, Minwoo 1 ; Lee, Hoonkyung 1 ; Park, Bae Ho 1 + Show...

  1. Configuration of ripple domains and their topological defects...

    Office of Scientific and Technical Information (OSTI)

    Authors: Park, Yeonggu 1 ; Choi, Jin Sik 2 ; Choi, Taekjib 3 ; Lee, Mi Jung 1 ; Jia, Quanxi 4 ; Park, Minwoo 1 ; Lee, Hoonkyung 1 ; Park, Bae Ho 1 + Show Author...

  2. The structure of the catalytic domain of a plant cellulose synthase and its assembly into dimers

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Olek, Anna T.; Rayon, Catherine; Makowski, Lee; Kim, Hyung Rae; Ciesielski, Peter; Badger, John; Paul, Lake N.; Ghosh, Subhangi; Kihara, Daisuke; Crowley, Michael; et al

    2014-07-10

    Cellulose microfibrils are para-crystalline arrays of several dozen linear (1→4)-β-d-glucan chains synthesized at the surface of the cell membrane by large, multimeric complexes of synthase proteins. Recombinant catalytic domains of rice (Oryza sativa) CesA8 cellulose synthase form dimers reversibly as the fundamental scaffold units of architecture in the synthase complex. Specificity of binding to UDP and UDP-Glc indicates a properly folded protein, and binding kinetics indicate that each monomer independently synthesizes single glucan chains of cellulose, i.e., two chains per dimer pair. In contrast to structure modeling predictions, solution x-ray scattering studies demonstrate that the monomer is a two-domain, elongatedmore » structure, with the smaller domain coupling two monomers into a dimer. The catalytic core of the monomer is accommodated only near its center, with the plant-specific sequences occupying the small domain and an extension distal to the catalytic domain. This configuration is in stark contrast to the domain organization obtained in predicted structures of plant CesA. As a result, the arrangement of the catalytic domain within the CesA monomer and dimer provides a foundation for constructing structural models of the synthase complex and defining the relationship between the rosette structure and the cellulose microfibrils they synthesize.« less

  3. Domain patterning by electron beam of MgO doped lithium niobate covered by resist

    SciTech Connect (OSTI)

    Shur, V. Ya. Chezganov, D. S.; Akhmatkhanov, A. R.; Kuznetsov, D. K.

    2015-06-08

    Periodical domain structuring by focused electron beam irradiation of MgO-doped lithium niobate (MgOCLN) single crystalline plate covered by resist layer was studied both experimentally and by computer simulation. The dependences of domain size on the charge dose and distance between isolated domains were measured. It has been shown that the quality of periodical domain pattern depends on the thickness of resist layer and electron energy. The experimentally obtained periodic domain structures have been divided into four types. The irradiation parameters for the most uniform patterning were obtained experimentally. It was shown by computer simulation that the space charge slightly touching the crystal surface produced the maximum value of electric field at the resist/LN interface thus resulting in the best pattern quality. The obtained knowledge allowed us to optimize the poling process and to make the periodical domain patterns in 1-mm-thick wafers with an area up to 1 × 5 mm{sup 2} and a period of 6.89 μm for green light second harmonic generation. Spatial distribution of the efficiency of light frequency conversion confirmed the high homogeneity of the tailored domain patterns.

  4. The structure of the catalytic domain of a plant cellulose synthase and its assembly into dimers

    SciTech Connect (OSTI)

    Olek, Anna T.; Rayon, Catherine; Makowski, Lee; Kim, Hyung Rae; Ciesielski, Peter; Badger, John; Paul, Lake N.; Ghosh, Subhangi; Kihara, Daisuke; Crowley, Michael; Himmel, Michael E.; Bolin, Jeffrey T.; Carpita, Nicholas C.

    2014-07-10

    Cellulose microfibrils are para-crystalline arrays of several dozen linear (1→4)-β-d-glucan chains synthesized at the surface of the cell membrane by large, multimeric complexes of synthase proteins. Recombinant catalytic domains of rice (Oryza sativa) CesA8 cellulose synthase form dimers reversibly as the fundamental scaffold units of architecture in the synthase complex. Specificity of binding to UDP and UDP-Glc indicates a properly folded protein, and binding kinetics indicate that each monomer independently synthesizes single glucan chains of cellulose, i.e., two chains per dimer pair. In contrast to structure modeling predictions, solution x-ray scattering studies demonstrate that the monomer is a two-domain, elongated structure, with the smaller domain coupling two monomers into a dimer. The catalytic core of the monomer is accommodated only near its center, with the plant-specific sequences occupying the small domain and an extension distal to the catalytic domain. This configuration is in stark contrast to the domain organization obtained in predicted structures of plant CesA. As a result, the arrangement of the catalytic domain within the CesA monomer and dimer provides a foundation for constructing structural models of the synthase complex and defining the relationship between the rosette structure and the cellulose microfibrils they synthesize.

  5. Terahertz time domain interferometry of a SIS tunnel junction and a quantum point contact

    SciTech Connect (OSTI)

    Karadi, C

    1995-09-01

    The author has applied the Terahertz Time Domain Interferometric (THz-TDI) technique to probe the ultrafast dynamic response of a Superconducting-Insulating-Superconducting (SIS) tunnel junction and a Quantum Point Contact (QPC). The THz-TDI technique involves monitoring changes in the dc current induced by interfering two picosecond electrical pulses on the junction as a function of time delay between them. Measurements of the response of the Nb/AlO{sub x}/Nb SIS tunnel junction from 75--200 GHz are in full agreement with the linear theory for photon-assisted tunneling. Likewise, measurements of the induced current in a QPC as a function of source-drain voltage, gate voltage, frequency, and magnetic field also show strong evidence for photon-assisted transport. These experiments together demonstrate the general applicability of the THz-TDI technique to the characterization of the dynamic response of any micron or nanometer scale device that exhibits a non-linear I-V characteristic. 133 refs., 49 figs.

  6. Thermal conductivity measurements via time-domain thermoreflectance for the characterization of radiation induced damage

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cheaito, Ramez; Gorham, Caroline S.; Carnegie Mellon Univ., Pittsburgh, PA; Misra, Amit; Hattar, Khalid; Hopkins, Patrick E.

    2015-05-01

    The progressive build up of displacement damage and fission products inside different systems and components of a nuclear reactor can lead to significant defect formation, degradation, and damage of the constituent materials. This structural modification can highly influence the thermal transport mechanisms and various mechanical properties of solids. In this paper we demonstrate the use of time-domain thermoreflectance (TDTR), a non-destructive method capable of measuring the thermal transport in material systems from nano to bulk scales, to study the effect of radiation damage and the subsequent changes in the thermal properties of materials. We use TDTR to show that displacementmore » damage from ion irradiation can significantly reduce the thermal conductivity of Optimized ZIRLO, a material used as fuel cladding in several current nuclear reactors. We find that the thermal conductivity of copper-niobium nanostructured multilayers does not change with helium ion irradiation doses of up to 1015 cm-2 and ion energy of 200 keV suggesting that these structures can be used and radiation tolerant materials in nuclear reactors. We compare the effect of ion doses and ion beam energies on the measured thermal conductivity of bulk silicon. Results demonstrate that TDTR thermal measurements can be used to quantify depth dependent damage.« less

  7. Thermal conductivity measurements via time-domain thermoreflectance for the characterization of radiation induced damage

    SciTech Connect (OSTI)

    Cheaito, Ramez; Gorham, Caroline S.; Misra, Amit; Hattar, Khalid; Hopkins, Patrick E.

    2015-05-01

    The progressive build up of displacement damage and fission products inside different systems and components of a nuclear reactor can lead to significant defect formation, degradation, and damage of the constituent materials. This structural modification can highly influence the thermal transport mechanisms and various mechanical properties of solids. In this paper we demonstrate the use of time-domain thermoreflectance (TDTR), a non-destructive method capable of measuring the thermal transport in material systems from nano to bulk scales, to study the effect of radiation damage and the subsequent changes in the thermal properties of materials. We use TDTR to show that displacement damage from ion irradiation can significantly reduce the thermal conductivity of Optimized ZIRLO, a material used as fuel cladding in several current nuclear reactors. We find that the thermal conductivity of copper-niobium nanostructured multilayers does not change with helium ion irradiation doses of up to 1015 cm-2 and ion energy of 200 keV suggesting that these structures can be used and radiation tolerant materials in nuclear reactors. We compare the effect of ion doses and ion beam energies on the measured thermal conductivity of bulk silicon. Results demonstrate that TDTR thermal measurements can be used to quantify depth dependent damage.

  8. Solution structure of telomere binding domain of AtTRB2 derived from Arabidopsis thaliana

    SciTech Connect (OSTI)

    Yun, Ji-Hye; Lee, Won Kyung; Kim, Heeyoun; Kim, Eunhee; Cheong, Chaejoon; Cho, Myeon Haeng; Lee, Weontae

    2014-09-26

    Highlights: • We have determined solution structure of Myb domain of AtTRB2. • The Myb domain of AtTRB2 is located in the N-terminal region. • The Myb domain of AtTRB2 binds to plant telomeric DNA without fourth helix. • Helix 2 and 3 of the Myb domain of AtTRB2 are involved in DNA recognition. • AtTRB2 is a novel protein distinguished from other known plant TBP. - Abstract: Telomere homeostasis is regulated by telomere-associated proteins, and the Myb domain is well conserved for telomere binding. AtTRB2 is a member of the SMH (Single-Myb-Histone)-like family in Arabidopsis thaliana, having an N-terminal Myb domain, which is responsible for DNA binding. The Myb domain of AtTRB2 contains three α-helices and loops for DNA binding, which is unusual given that other plant telomere-binding proteins have an additional fourth helix that is essential for DNA binding. To understand the structural role for telomeric DNA binding of AtTRB2, we determined the solution structure of the Myb domain of AtTRB2 (AtTRB2{sub 1–64}) using nuclear magnetic resonance (NMR) spectroscopy. In addition, the inter-molecular interaction between AtTRB2{sub 1–64} and telomeric DNA has been characterized by the electrophoretic mobility shift assay (EMSA) and NMR titration analyses for both plant (TTTAGGG)n and human (TTAGGG)n telomere sequences. Data revealed that Trp28, Arg29, and Val47 residues located in Helix 2 and Helix 3 are crucial for DNA binding, which are well conserved among other plant telomere binding proteins. We concluded that although AtTRB2 is devoid of the additional fourth helix in the Myb-extension domain, it is able to bind to plant telomeric repeat sequences as well as human telomeric repeat sequences.

  9. Magnetism reflectometer study shows LiF layers improve efficiency in spin valve devices

    SciTech Connect (OSTI)

    Bardoel, Agatha A; Lauter, Valeria; Szulczewski, Greg J

    2012-01-01

    New, more efficient materials for spin valves - a device used in magnetic sensors, random access memories, and hard disk drives - may be on the way based on research using the magnetism reflectometer at Oak Ridge National Laboratory (ORNL). Spin valve devices work by means of two or more conducting magnetic material layers that alternate their electrical resistance depending on the layers alignment. Giant magnetoresistance is a quantum mechanical effect first observed in thin film structures about 20 years ago. The effect is observed as a significant change in electrical resistance, depending on whether the magnetization of adjacent ferromagnetic layers is in a parallel or an antiparallel magnetic alignment. 'What we are doing here is developing new materials. The search for new materials suitable for injecting and transferring carriers with a preferential spin orientation is most important for the development of spintronics,' said Valeria Lauter, lead instrument scientist on the magnetism reflectometer at the Spallation Neutron Source (SNS), who collaborated on the experiment. The researchers discovered that the conductivity of such materials is improved when an organic polymer semiconductor layer is placed between the magnetic materials. Organic semiconductors are now the material of choice for future spin valve devices because they preserve spin coherence over longer times and distances than conventional semiconductors. While research into spin valves has been ongoing, research into organic semiconductors is recent. Previous research has shown that a 'conductivity mismatch' exists in spin valve systems in which ferromagnetic metal electrodes interface with such organic semiconductors as Alq3 ({pi}-conjugated molecule tris(8-hydroxy-quinoline) aluminium). This mismatch limits the efficient injection of the electrons from the electrodes at the interface with the semiconductor material. However, lithium fluoride (LiF), commonly used in light-emitting diodes, has been found to enhance the injection of electrons through the semiconductor. Researchers from the University of Alabama and ORNL used polarized neutrons at the magnetism reflectometer at SNS to investigate the electronic, magnetic, and structural properties of the electrodes in a novel system. In this system, the magnetic layers cobalt and Ni{sub 80}Fe{sub 20} are interfaced with spacer layers composed of the organic semiconductor Alq3. A coupling layer of LiF is inserted to separate the magnetized layers from the semiconductor. 'ALQ3 is an organic semiconductor material,' said Lauter. 'Normally in these systems a first magnetic layer is grown on a hard substrate so that one can get the controlled magnetic parameters. Then you grow the organic semiconductor layer, followed by another magnetic material layer, such as cobalt.' In addition to determining the effect of the LiF layers on the efficiency of the electron injection, the researchers wanted to determine the magnetic properties of the cobalt and Ni{sub 80}Fe{sub 20} as well as the interfacial properties: whether there is interdiffusion of cobalt through the LiF layer to the semiconductor, for example. The researchers used polarized neutrons at beam line 4A to probe the entire, layer-by-layer assembly of the system. 'Reflectometry with polarized neutrons is a perfect method to study thin magnetic films,' Lauter said. 'These thin films - if you put one on a substrate, you see it just like a mirror. However, this mirror has a very complicated internal multilayer structure. The neutrons look inside this complicated structure and characterize each and every interface. Due to the depth sensitivity of the method, we measure the structural and magnetic properties of each layer with the resolution of 0.5 nm. The neutron scattering results found that inserting LiF as a barrier significantly improves the quality of the interface, increasing the injection of electrons from the magnetic layer through the organic semiconductor in the spin valve and enhancing the overall properties of the system. In related work the magnetic properties of the cobalt film and the permalloy Ni{sub 80}Fe{sub 20} were characterized. Cobalt in particular needed attention, as it cannot be grown epitaxially (i.e., deposited) on an organic semiconductor film. Cobalt becomes polycrystalline or amorphous, and this affects its magnetic properties. The data from the first experiment showed that the cobalt layer in the system 'did not have typical magnetic properties,' Lauter said. 'The results showed that the cobalt had low magnetization. To improve the efficiency, the cobalt magnetization should be much higher. So this experiment helped us to improve the growth conditions and to get a cobalt layer with better magnetic properties.' In a subsequent experiment the researchers increased the magnetization of the cobalt, and a follow-up paper is in progress.

  10. The Importance of Domain Size and Purity in High-Efficiency Organic Solar

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cells The Importance of Domain Size and Purity in High-Efficiency Organic Solar Cells The Importance of Domain Size and Purity in High-Efficiency Organic Solar Cells Print Wednesday, 27 March 2013 00:00 The efficiency of polymer/organic photovoltaic cells hinges on excitons-electron/hole pairs energized by sunlight-getting to the interfaces of donor and acceptor domains quickly, before recombining. At the interfaces, they become free charges that must then reach device electrodes. With the

  11. Axial current generation by P-odd domains in QCD matter

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Iatrakis, Ioannis; Yin, Yi; Lin, Shu

    2015-06-23

    The dynamics of topological domains which break parity (P) and charge-parity (CP) symmetry of QCD are studied. We derive in a general setting that those local domains will generate an axial current and quantify the strength of the induced axial current. Thus, our findings are verified in a top-down holographic model. The relation between the real time dynamics of those local domains and the chiral magnetic field is also elucidated. We finally argue that such an induced axial current would be phenomenologically important in a heavy-ion collisions experiment.

  12. X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires Print The quest to increase both computer data-storage density and the speed at which one can read and write the information remains unconsummated. One novel concept is based on the use of a local electric current to push magnetic domain walls along a thin nanowire. A German, Korean, Berkeley Lab team has used the x-ray microscope XM-1 at the ALS to demonstrate that magnetic domain walls in curved permalloy nanowires can be

  13. X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires Print The quest to increase both computer data-storage density and the speed at which one can read and write the information remains unconsummated. One novel concept is based on the use of a local electric current to push magnetic domain walls along a thin nanowire. A German, Korean, Berkeley Lab team has used the x-ray microscope XM-1 at the ALS to demonstrate that magnetic domain walls in curved permalloy nanowires can be

  14. X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires Print The quest to increase both computer data-storage density and the speed at which one can read and write the information remains unconsummated. One novel concept is based on the use of a local electric current to push magnetic domain walls along a thin nanowire. A German, Korean, Berkeley Lab team has used the x-ray microscope XM-1 at the ALS to demonstrate that magnetic domain walls in curved permalloy nanowires can be

  15. X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires Print The quest to increase both computer data-storage density and the speed at which one can read and write the information remains unconsummated. One novel concept is based on the use of a local electric current to push magnetic domain walls along a thin nanowire. A German, Korean, Berkeley Lab team has used the x-ray microscope XM-1 at the ALS to demonstrate that magnetic domain walls in curved permalloy nanowires can be

  16. X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires Print Wednesday, 26 September 2007 00:00 The quest to increase both computer data-storage density and the speed at which one can read and write the information remains unconsummated. One novel concept is based on the use of a local electric current to push magnetic domain walls along a thin nanowire. A German, Korean, Berkeley Lab team has used the x-ray

  17. V-084: RSA Archer eGRC Permits Cross-Site Scripting, Cross-Domain Access,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Clickjacking, and File Upload Attacks | Department of Energy 84: RSA Archer eGRC Permits Cross-Site Scripting, Cross-Domain Access, Clickjacking, and File Upload Attacks V-084: RSA Archer eGRC Permits Cross-Site Scripting, Cross-Domain Access, Clickjacking, and File Upload Attacks February 5, 2013 - 12:01am Addthis PROBLEM: RSA Archer eGRC Permits Cross-Site Scripting, Cross-Domain Access, Clickjacking, and File Upload Attacks PLATFORM: RSA Archer SmartSuite Framework version 4.x RSA Archer

  18. X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires Print The quest to increase both computer data-storage density and the speed at which one can read and write the information remains unconsummated. One novel concept is based on the use of a local electric current to push magnetic domain walls along a thin nanowire. A German, Korean, Berkeley Lab team has used the x-ray microscope XM-1 at the ALS to demonstrate that magnetic domain walls in curved permalloy nanowires can be

  19. X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires Print The quest to increase both computer data-storage density and the speed at which one can read and write the information remains unconsummated. One novel concept is based on the use of a local electric current to push magnetic domain walls along a thin nanowire. A German, Korean, Berkeley Lab team has used the x-ray microscope XM-1 at the ALS to demonstrate that magnetic domain walls in curved permalloy nanowires can be

  20. X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    X-Ray Imaging Current-Driven Magnetic Domain-Wall Motion in Nanowires Print The quest to increase both computer data-storage density and the speed at which one can read and write the information remains unconsummated. One novel concept is based on the use of a local electric current to push magnetic domain walls along a thin nanowire. A German, Korean, Berkeley Lab team has used the x-ray microscope XM-1 at the ALS to demonstrate that magnetic domain walls in curved permalloy nanowires can be

  1. A time-domain estimation of wall conduction transfer function coefficients

    SciTech Connect (OSTI)

    Davies, M.G.

    1996-11-01

    The wall and roof transfer function coefficients, b{sub n} and d{sub n}, listed in the 1993 ASHRAE Fundamentals Handbook, have up to now been derived using laplace and Z-transform methods. This paper shows that they can be readily evaluated using straightforward time-domain solutions of the Fourier continuity equation. These include the response of a wall to a ramp increase in temperature and its transient response. The values of d{sub n} can be found from the first few terms in the series of wall decay times in the transient solution. The solutions are combined using a form of Fourier analysis. Appropriate layer transmission matrices enable one to find the wall`s overall characteristics readily. The wall response factors {phi}{sub j} can thus be found. The b{sub n} transfer coefficients are related to the {phi}{sub j} and d{sub n} values. The approach is illustrated using the data for wall group 6. Allowing for conversion from I-P to SI units, the present approach gives results that are almost identical to those listed. It shows, however, that the performance of the coefficients is very specific to the wall from which they were derived. The b{sub n} and d{sub n} values listed in the Handbook permit an estimate to be made of the wall response factors, including the time of peak flow and the first decay time. For heavy walls, however, values beyond d{sub 6} may be needed.

  2. The Importance of Domain Size and Purity in High-Efficiency Organic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Importance of Domain Size and Purity in High-Effi... Why are efficient and affordable solar cells so highly coveted? Volume. The amount of solar energy lighting up ...

  3. A 1.3-Å Structure of Zinc-bound N-terminal Domain of Calmodulin...

    Office of Scientific and Technical Information (OSTI)

    Journal Article: A 1.3- Structure of Zinc-bound N-terminal Domain of Calmodulin Elucidates Potential Early Ion-binding Step Citation Details In-Document Search Title: A 1.3- ...

  4. Compliant ferroelastic domains in epitaxial Pb(Zr,Ti)O{sub 3} thin films

    SciTech Connect (OSTI)

    Feigl, L.; McGilly, L. J.; Sandu, C. S.; Setter, N.

    2014-04-28

    Ordered patterns of highly compliant ferroelastic domains have been created by use of tensile strained epitaxial Pb(Zr,Ti)O{sub 3} thin films, of very low defect density, grown on DyScO{sub 3} substrates. The effect of 180° switching on well-ordered a/c 90° domain patterns is investigated by a combination of transmission electron microscopy, piezoelectric force microscopy, and X-ray diffraction. It is shown that ferroelastic a-domains, having an in-plane polarization, can be created and completely removed on a local level by an out-of-plane electric field. The modifications of the ferroelastic domain pattern can be controlled by varying the parameters used during switching with a piezoresponse force microscope to produce the desired arrangement.

  5. The TLR4 agonist fibronectin extra domain A is cryptic, exposed...

    Office of Scientific and Technical Information (OSTI)

    matrix cancer vaccine Citation Details In-Document Search Title: The TLR4 agonist fibronectin extra domain A is cryptic, exposed by elastase-2; use in a fibrin matrix cancer ...

  6. Coiled-coil dimerization of the LOV2 domain of the blue-light...

    Office of Scientific and Technical Information (OSTI)

    blue-light photoreceptor phototropin 1 from Arabidopsis thaliana Citation Details In-Document Search Title: Coiled-coil dimerization of the LOV2 domain of the blue-light ...

  7. Analysis of electron capture process in charge pumping sequence using time domain measurements

    SciTech Connect (OSTI)

    Hori, Masahiro Watanabe, Tokinobu; Ono, Yukinori; Tsuchiya, Toshiaki

    2014-12-29

    A method for analyzing the electron capture process in the charge pumping (CP) sequence is proposed and demonstrated. The method monitors the electron current in the CP sequence in time domain. This time-domain measurements enable us to directly access the process of the electron capture to the interface defects, which are obscured in the conventional CP method. Using the time-domain measurements, the rise time dependence of the capture process is systematically investigated. We formulate the capture process based on the rate equation and derive an analytic form of the current due to the electron capture to the defects. Based on the formula, the experimental data are analyzed and the capture cross section is obtained. In addition, the time-domain data unveil that the electron capture process completes before the electron channel opens, or below the threshold voltage in a low frequency range of the pulse.

  8. Computation of Domain-Averaged Irradiance with a Simple Two-Stream...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    is then assumed that the domain averaged irradiance F at the bottom of two layers is , Fd ) C exp( ) , ; ( P C 1 F 0 0 0 u where P is a gamma distribution expressing the...

  9. Secondary PDZ domain-binding site on class B plexins enhances...

    Office of Scientific and Technical Information (OSTI)

    Title: Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF Authors: Pascoe, Heath G. ; Gutowski, Stephen ; Chen, Hua ; Brautigam, Chad A. ; ...

  10. Dynamics of spintronic materials: Exploration in the time and frequency domain

    SciTech Connect (OSTI)

    Zabel, Hartmut

    2014-12-14

    X-ray and neutron reflectivity are mature experimental techniques for the exploration of film thicknesses and interface roughnesses on the nanoscale. Combining with photon and neutron polarization, these methods can be carried forward to the analysis of magnetic thin films and magnetic domain structures. New opportunities open up when these methods are used either in the time or in the frequency domain. Then dynamical processes can be studied such as domain oscillations, domain propagation, precession of spins, and damping effects. Two methods are discussed which have been developed recently: polarized neutron reflectivity from magnetic films in an alternating magnetic field and time resolved resonant magnetic x-ray reflectivity of the free precessional dynamics in films and multilayers.

  11. Magnetic soft x-ray microscopy of the domain wall depinning process...

    Office of Scientific and Technical Information (OSTI)

    Magnetic soft x-ray microscopy of the domain wall depinning process in permalloy magnetic nanowires Citation Details In-Document Search Title: Magnetic soft x-ray microscopy of the ...

  12. Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8

    SciTech Connect (OSTI)

    Wang, Chengliang; Zhang, Qiongdi; Hang, Tianrong; Tao, Yue; Ma, Xukai; Wu, Minhao; Zhang, Xuan Zang, Jianye

    2015-08-28

    The structure of the complex of NO66 and Rpl8 was solved in the native state and NO66 recognizes the consensus motif NHXH . Tetramerization is required for efficient substrate binding and catalysis by NO66. The JmjC domain-containing proteins belong to a large family of oxygenases possessing distinct substrate specificities which are involved in the regulation of different biological processes, such as gene transcription, RNA processing and translation. Nucleolar protein 66 (NO66) is a JmjC domain-containing protein which has been reported to be a histone demethylase and a ribosome protein 8 (Rpl8) hydroxylase. The present biochemical study confirmed the hydroxylase activity of NO66 and showed that oligomerization is required for NO66 to efficiently catalyze the hydroxylation of Rpl8. The structures of NO66{sup 176–C} complexed with Rpl8{sup 204–224} in a tetrameric form and of the mutant protein M2 in a dimeric form were solved. Based on the results of structural and biochemical analyses, the consensus sequence motif NHXH recognized by NO66 was confirmed. Several potential substrates of NO66 were found by a BLAST search according to the consensus sequence motif. When binding to substrate, the relative positions of each subunit in the NO66 tetramer shift. Oligomerization may facilitate the motion of each subunit in the NO66 tetramer and affect the catalytic activity.

  13. The C-Terminal RpoN Domain of sigma54 Forms an unpredictedHelix-Turn-Helix Motif Similar to domains of sigma70

    SciTech Connect (OSTI)

    Doucleff, Michaeleen; Malak, Lawrence T.; Pelton, Jeffrey G.; Wemmer, David E.

    2005-11-01

    The ''{delta}'' subunit of prokaryotic RNA-polymerase allows gene-specific transcription initiation. Two {sigma} families have been identified, {sigma}{sup 70} and {sigma}{sup 54}, which use distinct mechanisms to initiate transcription and share no detectable sequence homology. Although the {sigma}{sup 70}-type factors have been well characterized structurally by x-ray crystallography, no high-resolution structural information is available for the {sigma}{sup 54}-type factors. Here we present the NMR derived structure of the C-terminal domain of {sigma}{sup 54} from Aquifex aeolicus. This domain (Thr323 to Gly389), which contains the highly conserved RpoN box sequence, consists of a poorly structured N-terminal tail followed by a three-helix bundle, which is surprisingly similar to domains of the {sigma}{sup 70}-type proteins. Residues of the RpoN box, which have previously been shown to be critical for DNA binding, form the second helix of an unpredicted helix-turn-helix motif. This structure's homology with other DNA binding proteins, combined with previous biochemical data, suggest how the C-terminal domain of {sigma}{sup 54} binds to DNA.

  14. Magnetic soft x-ray microscopy of the domain wall depinning process in

    Office of Scientific and Technical Information (OSTI)

    permalloy magnetic nanowires (Journal Article) | SciTech Connect Magnetic soft x-ray microscopy of the domain wall depinning process in permalloy magnetic nanowires Citation Details In-Document Search Title: Magnetic soft x-ray microscopy of the domain wall depinning process in permalloy magnetic nanowires Authors: Im, Mi-Young ; Bocklage, Lars ; Meier, Guido ; Fischer, Peter Publication Date: 2011-10-27 OSTI Identifier: 1172969 Report Number(s): LBNL-5866E DOE Contract Number:

  15. Dependence of effective internal field of congruent lithium niobate on its domain configuration and stability

    SciTech Connect (OSTI)

    Das, Ranjit E-mail: souvik2cat@gmail.com Ghosh, Souvik E-mail: souvik2cat@gmail.com Chakraborty, Rajib E-mail: souvik2cat@gmail.com

    2014-06-28

    Congruent lithium niobate is characterized by its internal field, which arises due to defect clusters within the crystal. Here, it is shown experimentally that this internal field is a function of the molecular configuration in a particular domain and also on the stability of that particular configuration. The measurements of internal field are done using interferometric technique, while the variation of domain configuration is brought about by room temperature high voltage electric field poling.

  16. Domain pinning near a single-grain boundary in tetragonal and rhombohedral

    Office of Scientific and Technical Information (OSTI)

    lead zirconate titanate films (Journal Article) | SciTech Connect Domain pinning near a single-grain boundary in tetragonal and rhombohedral lead zirconate titanate films Citation Details In-Document Search Title: Domain pinning near a single-grain boundary in tetragonal and rhombohedral lead zirconate titanate films Authors: Marincel, D. M. ; Zhang, H. R. ; Britson, J. ; Belianinov, A. ; Jesse, S. ; Kalinin, S. V. ; Chen, L. Q. ; Rainforth, W. M. ; Reaney, I. M. ; Randall, C. A. ;

  17. Phase Behavior and Domain Size in Sphingomyelin-Containing Lipid Bilayers

    SciTech Connect (OSTI)

    Petruzielo, Robin S [Cornell University; Heberle, Frederick A [ORNL; Drazba, Paul [ORNL; Katsaras, John [ORNL; Feigenson, Gerald [Cornell University

    2013-01-01

    Membrane raft size measurements are crucial to understanding the stability and functionality of rafts in cells. The challenge of accurately measuring raft size is evidenced by the disparate reports of domain sizes, which range from nanometers to microns for the ternary model membrane system sphingomyelin (SM)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)/cholesterol (Chol). Using F rster resonance energy transfer (FRET) and differential scanning calorimetry (DSC), we established phase diagrams for porcine brain SM (bSM)/dioleoyl-sn-glycero-3-phosphocholine (DOPC)/Chol and bSM/POPC/Chol at 15 and 25 C. By combining two techniqueswith different spatial sensitivities, namely FRET and small-angle neutron scattering (SANS),we have significantly narrowed the uncertainty in domain size estimates for bSM/POPC/Chol mixtures. Compositional trends in FRET data revealed coexisting domains at 15 and 25 C for bothmixtures, while SANS measurements detected no domain formation for bSM/POPC/Chol. Together these results indicate that liquid domains in bSM/POPC/Chol are between 2 and 7 nmin radius at 25 C: that is, domains must be on the order of the 2 6 nmF rster distance of the FRET probes, but smaller than the ~7 nm minimum cluster size detectable with SANS. However, for palmitoyl SM (PSM)/POPC/Chol at a similar composition, SANS detected coexisting liquid domains. This increase in domain size upon replacing the natural SMcomponent (which consists of amixture of chain lengths) with synthetic PSM, suggests a role for SM chain length in modulating raft size in vivo.

  18. Structure of the DUF2233 Domain in Bacteria and the Stuttering-associated

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    UCE Glycoprotein | Stanford Synchrotron Radiation Lightsource the DUF2233 Domain in Bacteria and the Stuttering-associated UCE Glycoprotein Wednesday, July 31, 2013 UCE figure DUF2233, a Domain of Unknown Function (DUF), is present in ~1200 bacterial and several viral and eukaryotic proteins. DUF2233 has been identified in proteins ranging in size from ~300-2000 residues. The 515 amino acid mammalian transmembrane glycoprotein α-N-acetylglucosamine-1-phosphodiester N-acetylglucosaminidase

  19. Dynamic load balancing algorithm for molecular dynamics based on Voronoi cells domain decompositions

    SciTech Connect (OSTI)

    Fattebert, J.-L.; Richards, D.F.; Glosli, J.N.

    2012-12-01

    We present a new algorithm for automatic parallel load balancing in classical molecular dynamics. It assumes a spatial domain decomposition of particles into Voronoi cells. It is a gradient method which attempts to minimize a cost function by displacing Voronoi sites associated with each processor/sub-domain along steepest descent directions. Excellent load balance has been obtained for quasi-2D and 3D practical applications, with up to 440106 particles on 65,536 MPI tasks.

  20. A Linked-Cell Domain Decomposition Method for Molecular Dynamics Simulation on a Scalable Multiprocessor

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yang, L. H.; Brooks III, E. D.; Belak, J.

    1992-01-01

    A molecular dynamics algorithm for performing large-scale simulations using the Parallel C Preprocessor (PCP) programming paradigm on the BBN TC2000, a massively parallel computer, is discussed. The algorithm uses a linked-cell data structure to obtain the near neighbors of each atom as time evoles. Each processor is assigned to a geometric domain containing many subcells and the storage for that domain is private to the processor. Within this scheme, the interdomain (i.e., interprocessor) communication is minimized.

  1. Post-deposition control of ferroelastic stripe domains and internal electric field by thermal treatment

    SciTech Connect (OSTI)

    Feigl, L.; Iwanowska, M.; Sandu, C. S.; Setter, N.; Janolin, P.-E.; Yamada, T.

    2015-01-19

    The dependence of the formation of ferroelastic stripe domain patterns on the thermal history is investigated by detailed piezoresponse force microscopy and X-ray diffraction experiments after and during annealing of tensile strained tetragonal Pb(Ti,Zr)O{sub 3} epitaxial thin films on DyScO{sub 3} substrates. In particular, the ferroelastic pattern is reversibly interchanged between a cross-hatched and a stripe domain pattern if the films are cooled at different rates after annealing above the formation temperature of a-domains. Different types of 180 and non-180 patterns can be created, depending on the thermal treatment. The changes in the 180 domain structure and lattice parameters are attributed to a change of oxygen vacancy concentration, which results in a modification of the internal electric field and unit cell size, causing also a shift of T{sub C}. Thermal treatment is done on rhombohedral La:BiFeO{sub 3} thin films as well. It is observed that also in these films, appropriate heat treatment modifies the domain pattern and films with a stripe domain pattern can be created, confirming the general validity of the developed model.

  2. Structure and Dynamics of Domains in Ferroelectric Nanostructures. In-situ TEM Studies

    SciTech Connect (OSTI)

    Pan, Xiaoqing

    2015-06-30

    The goal of this project was to explore the structure and dynamic behaviors of ferroelectric domains in ferroelectric thin films and nanostructures by advanced transmission electron microscopy (TEM) techniques in close collaboration with phase field modeling. The experimental techniques used include aberration-corrected sub-Å resolution TEM and in-situ TEM using a novel scanning tunneling microscopy (STM) - TEM holder that allows the direct observation of nucleation and dynamic evolution of ferroelectric domains under applied electric field. Specifically, this project was aimed to (1) to study the roles of static electrical boundary conditions and electrical charge in controlling the equilibrium domain structures of BiFeO3 thin films with controlled substrate constraints, (2) to explore the fundamental mechanisms of ferroelectric domain nucleation, growth, and switching under an applied electric field in both uniform thin films and nanostructures, and to understand the roles of crystal defects such as dislocations and interfaces in these processes, (3) to understand the physics of ferroelectric domain walls and the influence of defects on the electrical switching of ferroelectric domains.

  3. Pre-Show Checklist

    Broader source: Energy.gov [DOE]

    Before you leave for your event, you should check that you are prepared and ready to go.  This checklist was designed to remind you of the steps you are required to take before leaving for your event.

  4. Ultraviolet laser-induced poling inhibition produces bulk domains in MgO-doped lithium niobate crystals

    SciTech Connect (OSTI)

    Boes, Andreas, E-mail: s3363819@student.rmit.edu.au; Steigerwald, Hendrik; Sivan, Vijay; Mitchell, Arnan [School of Electrical and Computer Engineering, RMIT University, Melbourne, Victoria 3001 (Australia); ARC Center for Ultra-high Bandwidth Devices for Optical Systems (CUDOS), RMIT University, Melbourne, Victoria 3001 (Australia); Yudistira, Didit [School of Electrical and Computer Engineering, RMIT University, Melbourne, Victoria 3001 (Australia); Wade, Scott [Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122 (Australia); Mailis, Sakellaris [Optoelectronics Research Centre, University of Southampton, Highfield, Southampton SO17 1BJ (United Kingdom); Soergel, Elisabeth [Institute of Physics, University of Bonn, Wegelerstr. 8, 53115 Bonn (Germany)

    2014-09-01

    We report the realization of high-resolution bulk domains achieved using a shallow, structured, domain inverted surface template obtained by UV laser-induced poling inhibition in MgO-doped lithium niobate. The quality of the obtained bulk domains is compared to those of the template and their application for second harmonic generation is demonstrated. The present method enables domain structures with a period length as small as 3??m to be achieved. Furthermore, we propose a potential physical mechanism that leads to the transformation of the surface template into bulk domains.

  5. Validation of Innovative Exploration Technologies for Newberry Volcano: Map showing location of wells permitted, drilled and seismic test 2012

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Jaffe, Todd

    2012-01-01

    Innovative Exploration Technologies for Newberry Volcano: Map showing location of wells permitted, drilled & seismic test, 2012

  6. Validation of Innovative Exploration Technologies for Newberry Volcano: Map showing location of wells permitted, drilled and seismic test 2012

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Jaffe, Todd

    Innovative Exploration Technologies for Newberry Volcano: Map showing location of wells permitted, drilled & seismic test, 2012

  7. Self-powdering and nonlinear optical domain structures in ferroelastic beta'-Gd{sub 2}(MoO{sub 4}){sub 3} crystals formed in glass

    SciTech Connect (OSTI)

    Tsukada, Y.; Honma, T.; Komatsu, T.

    2009-08-15

    Ferroelastic beta'-Gd{sub 2}(MoO{sub 4}){sub 3}, (GMO), crystals are formed through the crystallization of 21.25Gd{sub 2}O{sub 3}-63.75MoO{sub 3}-15B{sub 2}O{sub 3} glass (mol%), and two scientific curious phenomena are observed. (1) GMO crystals formed in the crystallization break into small pieces with a triangular prism or pyramid shape having a length of 50-500 {mu}m spontaneously during the crystallizations in the inside of an electric furnace, not during the cooling in air after the crystallization. This phenomenon is called 'self-powdering phenomenon during crystallization' in this paper. (2) Each self-powdered GMO crystal grain shows a periodic domain structure with different refractive indices, and a spatially periodic second harmonic generation (SHG) depending on the domain structure is observed. It is proposed from polarized micro-Raman scattering spectra and the azimuthal dependence of second harmonic intensities that GMO crystals are oriented in each crystal grain and the orientation of (MoO{sub 4}){sup 2-} tetrahedra in GMO crystals changes periodically due to spontaneous strains in ferroelastic GMO crystals. - Graphical abstract: This figure shows the polarized optical photograph at room temperature for a particle (piece) obtained by a heat treatment of the glass at 590 deg. C for 2 h in an electric furnace in air. This particle was obtained through the self-powdering behavior in the crystallization of glass. The periodic domain structure is observed. Ferroelastic beta'-Gd{sub 2}(MoO{sub 4}){sub 3} crystals are formed in the particle, and second harmonic generations are detected, depending on the domain structure.

  8. Structural and Energetic Analysis of Activiation by a Cyclic Nucleotide Binding Domain

    SciTech Connect (OSTI)

    Altieri,S.; Clayton, G.; Silverman, W.; Olivares, A.; De La Cruz, E.; Thomas, L.; Morais-Cabral, J.

    2008-01-01

    MlotiK1 is a prokaryotic homolog of cyclic-nucleotide-dependent ion channels that contains an intracellular C-terminal cyclic nucleotide binding (CNB) domain. X-ray structures of the CNB domain have been solved in the absence of ligand and bound to cAMP. Both the full-length channel and CNB domain fragment are easily expressed and purified, making MlotiK1 a useful model system for dissecting activation by ligand binding. We have used X-ray crystallography to determine three new MlotiK1 CNB domain structures: a second apo configuration, a cGMP-bound structure, and a second cAMP-bound structure. In combination, the five MlotiK1 CNB domain structures provide a unique opportunity for analyzing, within a single protein, the structural differences between the apo state and the bound state, and the structural variability within each state. With this analysis as a guide, we have probed the nucleotide selectivity and importance of specific residue side chains in ligand binding and channel activation. These data help to identify ligand-protein interactions that are important for ligand dependence in MlotiK1 and, more globally, in the class of nucleotide-dependent proteins.

  9. Ionic field effect and memristive phenomena in single-point ferroelectric domain switching

    SciTech Connect (OSTI)

    Ievlev, Anton; Morozovska, A. N.; Eliseev, E. A.; Shur, Vladimir Ya.; Kalinin, Sergei V

    2014-01-01

    Electric field induced polarization switching underpins most functional applications of ferroelectric materials in information technology, materials science, and optoelectronics. In the last 20 years, much attention has been focused on the switching of individual domains using scanning probe microscopy, both as model of ferroelectric data storage and approach to explore fundamental physics of ferroelectric switching. The classical picture of tip induced switching includes formation of cylindrical domain oriented along the tip field, with the domain size is largely determined by the tip-induced field distribution and domain wall motion kinetics. The polarization screening is recognized as a necessary precondition to the stability of ferroelectric phase; however, screening processes are generally considered to be uniformly efficient and not leading to changes in switching behavior. Here, we demonstrate that single-point tip-induced polarization switching can give rise to a surprisingly broad range of domain morphologies, including radial and angular instabilities. These behaviors are traced to the surface screening charge dynamics, which in some cases can even give rise to anomalous switching against the electric field (ionic field effect). The implications of these behaviors for ferroelectric materials and devices are discussed.

  10. Template-based CTA to x-ray angio rigid registration of coronary arteries in frequency domain with automatic x-ray segmentation

    SciTech Connect (OSTI)

    Aksoy, Timur; Unal, Gozde; Demirci, Stefanie; Navab, Nassir; Degertekin, Muzaffer

    2013-10-15

    Purpose: A key challenge for image guided coronary interventions is accurate and absolutely robust image registration bringing together preinterventional information extracted from a three-dimensional (3D) patient scan and live interventional image information. In this paper, the authors present a novel scheme for 3D to two-dimensional (2D) rigid registration of coronary arteries extracted from preoperative image scan (3D) and a single segmented intraoperative x-ray angio frame in frequency and spatial domains for real-time angiography interventions by C-arm fluoroscopy.Methods: Most existing rigid registration approaches require a close initialization due to the abundance of local minima and high complexity of search algorithms. The authors' method eliminates this requirement by transforming the projections into translation-invariant Fourier domain for estimating the 3D pose. For 3D rotation recovery, template Digitally Reconstructed Radiographs (DRR) as candidate poses of 3D vessels of segmented computed tomography angiography are produced by rotating the camera (image intensifier) around the DICOM angle values with a specific range as in C-arm setup. The authors have compared the 3D poses of template DRRs with the segmented x-ray after equalizing the scales in three domains, namely, Fourier magnitude, Fourier phase, and Fourier polar. The best rotation pose candidate was chosen by one of the highest similarity measures returned by the methods in these domains. It has been noted in literature that frequency domain methods are robust against noise and occlusion which was also validated by the authors' results. 3D translation of the volume was then recovered by distance-map based BFGS optimization well suited to convex structure of the authors' objective function without local minima due to distance maps. A novel automatic x-ray vessel segmentation was also performed in this study.Results: Final results were evaluated in 2D projection space for patient data; and with ground truth values and landmark distances for the images acquired with a solid phantom vessel. Results validate that rotation recovery in frequency domain is robust against differences in segmentations in two modalities. Distance-map translation is successful in aligning coronary trees with highest possible overlap.Conclusions: Numerical and qualitative results show that single view rigid alignment in projection space is successful. This work can be extended with multiple views to resolve depth ambiguity and with deformable registration to account for nonrigid motion in patient data.

  11. Impact of pulse poling on static and dynamic ferroelastic-domain contributions in tetragonal Pb(Ti, Zr)O{sub 3} films determined by in-situ x–ray diffraction analysis

    SciTech Connect (OSTI)

    Nakajima, Mitsumasa; Wada, Ayumi; Ehara, Yoshitaka; Funakubo, Hiroshi; Yamada, Tomoaki; Kobayashi, Takeshi

    2014-11-21

    The effects of bipolar pulse poling on the ferroelastic domain structure and their contribution to the electrical and piezoelectric properties of Pb(Ti{sub 0.7}Zr{sub 0.3})O{sub 3} films are investigated. Micro x-ray diffraction measurements clearly show that the volume fraction of the c-domain increases irreversibly as the poling field is increased, leading to changes in the remanent polarization, dielectric constant, and piezoelectric coefficient. Theoretical estimations well explain the changes of remanent polarization and dielectric constant, but the increase in piezoelectric coefficient is much larger than the theoretical estimation. In-situ x-ray diffraction analysis under an electric field reveals that this disagreement is due to the unexpected activation of the ferroelastic domain wall motion. Our results provide new insight into the poling effect on the electric and piezoelectric properties of ferroelectric films.

  12. Stability of a pinned magnetic domain wall as a function of its internal configuration

    SciTech Connect (OSTI)

    Montaigne, F.; Duluard, A.; Briones, J.; Lacour, D.; Hehn, M.; Childress, J. R.

    2015-01-14

    It is shown that there are many stable configurations for a domain wall pinned by a notch along a magnetic stripe. The stability of several of these configurations is investigated numerically as a function of the thickness of the magnetic film. The depinning mechanism depends on the structure of the domain wall and on the thickness of the magnetic film. In the case of a spin-valve structure, it appears that the stray fields emerging from the hard layer at the notch location influence the stability of the micromagnetic configuration. Different depinning mechanisms are thus observed for the same film thickness depending on the magnetization orientation of the propagating domain. This conclusion qualitatively explains experimental magnetoresistance measurements.

  13. Domain-Specific Languages For Developing and Deploying Signature Discovery Workflows

    SciTech Connect (OSTI)

    Jacob, Ferosh; Wynne, Adam S.; Liu, Yan; Gray, Jeff

    2013-12-02

    Domain-agnostic Signature Discovery entails scientific investigation across multiple domains through the re-use of existing algorithms into workflows. The existing algorithms may be written in any programming language for various hardware architectures (e.g., desktops, commodity clusters, and specialized parallel hardware platforms). This raises an engineering issue in generating Web services for heterogeneous algorithms so that they can be composed into a scientific workflow environment (e.g., Taverna). In this paper, we present our software tool that defines two simple Domain-Specific Languages (DSLs) to automate these processes: SDL and WDL. Our Service Description Language (SDL) describes key elements of a signature discovery algorithm and generates the service code. The Workflow Description Language (WDL) describes the pipeline of services and generates deployable artifacts for the Taverna workflow management system. We demonstrate our tool with a landscape classification example that is represented by BLAST workflows composed of services that wrap original scripts.

  14. Lattice QCD with Domain Decomposition on Intel Xeon Phi Co-Processors

    SciTech Connect (OSTI)

    Heybrock, Simon; Joo, Balint; Kalamkar, Dhiraj D.; Smelyanskiy, Mikhail; Vaidyanathan, Karthikeyan; Wettig, Tilo; Dubey, Pradeep

    2014-12-01

    The gap between the cost of moving data and the cost of computing continues to grow, making it ever harder to design iterative solvers on extreme-scale architectures. This problem can be alleviated by alternative algorithms that reduce the amount of data movement. We investigate this in the context of Lattice Quantum Chromodynamics and implement such an alternative solver algorithm, based on domain decomposition, on Intel Xeon Phi co-processor (KNC) clusters. We demonstrate close-to-linear on-chip scaling to all 60 cores of the KNC. With a mix of single- and half-precision the domain-decomposition method sustains 400-500 Gflop/s per chip. Compared to an optimized KNC implementation of a standard solver [1], our full multi-node domain-decomposition solver strong-scales to more nodes and reduces the time-to-solution by a factor of 5.

  15. Candidate Cell and Matrix Interaction Domains on the Collagen Fibril, the Predominant Protein of Vertebrates

    SciTech Connect (OSTI)

    Sweeney, Shawn M.; Orgel, Joseph P.; Fertala, Andrzej; McAuliffe, Jon D.; Turner, Kevin R.; Di Lullo, Gloria A.; Chen, Steven; Antipova, Olga; Perumal, Shiamalee; Ala-Kokko, Leena; Forlinoi, Antonella; Cabral, Wayne A.; Barnes, Aileen M.; Marini, Joan C.; San Antonio, James D.

    2008-07-18

    Type I collagen, the predominant protein of vertebrates, polymerizes with type III and V collagens and non-collagenous molecules into large cable-like fibrils, yet how the fibril interacts with cells and other binding partners remains poorly understood. To help reveal insights into the collagen structure-function relationship, a data base was assembled including hundreds of type I collagen ligand binding sites and mutations on a two-dimensional model of the fibril. Visual examination of the distribution of functional sites, and statistical analysis of mutation distributions on the fibril suggest it is organized into two domains. The 'cell interaction domain' is proposed to regulate dynamic aspects of collagen biology, including integrin-mediated cell interactions and fibril remodeling. The 'matrix interaction domain' may assume a structural role, mediating collagen cross-linking, proteoglycan interactions, and tissue mineralization. Molecular modeling was used to superimpose the positions of functional sites and mutations from the two-dimensional fibril map onto a three-dimensional x-ray diffraction structure of the collagen microfibril in situ, indicating the existence of domains in the native fibril. Sequence searches revealed that major fibril domain elements are conserved in type I collagens through evolution and in the type II/XI collagen fibril predominant in cartilage. Moreover, the fibril domain model provides potential insights into the genotype-phenotype relationship for several classes of human connective tissue diseases, mechanisms of integrin clustering by fibrils, the polarity of fibril assembly, heterotypic fibril function, and connective tissue pathology in diabetes and aging.

  16. Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vortices Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic Vortices Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic Vortices Print Wednesday, 27 August 2008 00:00 Soft magnetic, micron-sized thin-film structures with magnetic vortices are intriguing systems that may one day be used in ultrafast computer memories. In such systems, the otherwise in-plane magnetization turns perpendicular to the plane at the center of the vortex, forming the vortex core.

  17. Solution Structure Analysis of Cytoplasmic Domain of Podocyte Protein Neph1

    Office of Scientific and Technical Information (OSTI)

    Using Small/Wide Angle X-ray Scattering (SWAXS) (Journal Article) | SciTech Connect Solution Structure Analysis of Cytoplasmic Domain of Podocyte Protein Neph1 Using Small/Wide Angle X-ray Scattering (SWAXS) Citation Details In-Document Search Title: Solution Structure Analysis of Cytoplasmic Domain of Podocyte Protein Neph1 Using Small/Wide Angle X-ray Scattering (SWAXS) Authors: Mallik L. ; Arif, E ; Sharma, P ; Rathore, Y ; Wong, H ; Holzman, L ; Ashish, A ; Nihalani, D Publication Date:

  18. A new frequency domain arc furnace model for iterative harmonic analysis

    SciTech Connect (OSTI)

    Mayordomo, J.G.; Beites, L.F.; Asensi, R.; Izzeddine, M.; Zabala, L.; Amantegui, J.

    1997-10-01

    This paper presents a new frequency domain Arc Furnace model for Iterative Harmonic Analysis (IHA) by means of a Newton method. Powerful analytical expressions for harmonic currents and their derivatives are obtained under the balanced conditions of the system. The model offers a three phase configuration where there is no path for homopolar currents. Moreover, it contemplates continuous and discontinuous evolution of the arc current. The solution obtained is validated by means of time domain simulations. Finally, the model was integrated in a harmonic power flow where studies have been performed in a network with more than 700 busbars and 7 actual Arc Furnace Loads.

  19. Gravitational waves from domain walls in the next-to-minimal supersymmetric standard model

    SciTech Connect (OSTI)

    Kadota, Kenji; Kawasaki, Masahiro; Saikawa, Ken’ichi

    2015-10-16

    The next-to-minimal supersymmetric standard model predicts the formation of domain walls due to the spontaneous breaking of the discrete Z{sub 3}-symmetry at the electroweak phase transition, and they collapse before the epoch of big bang nucleosynthesis if there exists a small bias term in the potential which explicitly breaks the discrete symmetry. Signatures of gravitational waves produced from these unstable domain walls are estimated and their parameter dependence is investigated. It is shown that the amplitude of gravitational waves becomes generically large in the decoupling limit, and that their frequency is low enough to be probed in future pulsar timing observations.

  20. Structure of the Kinase Domain of CaMKII and Modeling the Holoenzyme

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structure of the Kinase Domain of CaMKII and Modeling the Holoenzyme Structure of the Kinase Domain of CaMKII and Modeling the Holoenzyme Print Wednesday, 31 May 2006 00:00 The rate and intensity of calcium (Ca2+) currents that oscillate through the plasma membrane around a cell affect such diverse phenomena as fertilization, the cardiac rhythm, and even the formation of memories. How does the cell sense these digital oscillations and transduce them into a cellular signal, such as changes in

  1. Electric field driven magnetic domain wall motion in ferromagnetic-ferroelectric heterostructures

    SciTech Connect (OSTI)

    Van de Wiele, Ben; Laurson, Lasse; Franke, Kvin J. A.; Dijken, Sebastiaan van

    2014-01-06

    We investigate magnetic domain wall (MDW) dynamics induced by applied electric fields in ferromagnetic-ferroelectric thin-film heterostructures. In contrast to conventional driving mechanisms where MDW motion is induced directly by magnetic fields or electric currents, MDW motion arises here as a result of strong pinning of MDWs onto ferroelectric domain walls (FDWs) via local strain coupling. By performing extensive micromagnetic simulations, we find several dynamical regimes, including instabilities such as spin wave emission and complex transformations of the MDW structure. In all cases, the time-averaged MDW velocity equals that of the FDW, indicating the absence of Walker breakdown.

  2. Soluble FGFR4 extracellular domain inhibits FGF19-induced activation of FGFR4 signaling and prevents nonalcoholic fatty liver disease

    SciTech Connect (OSTI)

    Chen, Qiang; The First Affiliated Hospital of Xiamen University, Xiamen ; Jiang, Yuan; An, Yuan; Zhao, Na; Zhao, Yang; Yu, Chundong

    2011-06-17

    Highlights: {yields} Soluble FGFR4 extracellular domain (FGFR4-ECD) was effectively expressed. {yields} FGFR4-ECD inhibited FGF19-induced activation of FGFR4 signaling. {yields} FGFR4-ECD reduced palmitic acid-induced steatosis of HepG2 cells. {yields} FGFR4-ECD reduced tetracycline-induced fatty liver in mice. {yields} FGFR4-ECD partially restored tetracycline-repressed PPAR{alpha} expression. -- Abstract: Fibroblast growth factor receptor 4 (FGFR4) is a transmembrane tyrosine kinase receptor that plays a crucial role in the regulation of hepatic bile acid and lipid metabolism. FGFR4 underlies high-fat diet-induced hepatic steatosis, suggesting that inhibition of FGFR4 activation may be an effective way to prevent or treat nonalcoholic fatty liver disease (NAFLD). To determine whether neutralization of FGFR4 ligands by soluble FGFR4 extracellular domain (FGFR4-ECD) can inhibit the activation of FGFR4, we constructed FGFR4-ECD expression vector and showed that FGFR4-ECD was effectively expressed in cells and secreted into culture medium. FGFR4-ECD inhibited FGF19-induced activation of FGFR4 signaling and reduced steatosis of HepG2 induced by palmitic acid in vitro. Furthermore, in a tetracycline-induced fatty liver model, expression of FGFR4-ECD in mouse liver reduced the accumulation of hepatic lipids and partially restored the expression of peroxisome proliferator-activated receptor {alpha} (PPAR{alpha}), which promotes the mitochondrial fatty acid beta-oxidation but is repressed by tetracycline. Taken together, these results demonstrate that FGFR4-ECD can block FGFR4 signaling and prevent hepatic steatosis, highlighting the potential value of inhibition of FGFR4 signaling as a method for therapeutic intervention against NAFLD.

  3. Configuration of ripple domains and their topological defects formed under local mechanical stress on hexagonal monolayer graphene

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Park, Yeonggu; Choi, Jin Sik; Choi, Taekjib; Lee, Mi Jung; Jia, Quanxi; Park, Minwoo; Lee, Hoonkyung; Park, Bae Ho

    2015-03-24

    Ripples in graphene are extensively investigated because they ensure the mechanical stability of two-dimensional graphene and affect its electronic properties. They arise from spontaneous symmetry breaking and are usually manifested in the form of domains with long-range order. It is expected that topological defects accompany a material exhibiting long-range order, whose functionality depends on characteristics of domains and topological defects. However, there remains a lack of understanding regarding ripple domains and their topological defects formed on monolayer graphene. Here we explore configuration of ripple domains and their topological defects in exfoliated monolayer graphenes on SiO₂/Si substrates using transverse shear microscope.more » We observe three-color domains with three different ripple directions, which meet at a core. Furthermore, the closed domain is surrounded by an even number of cores connected together by domain boundaries, similar to topological vortex and anti-vortex pairs. In addition, we have found that axisymmetric three-color domains can be induced around nanoparticles underneath the graphene. This fascinating configuration of ripple domains may result from the intrinsic hexagonal symmetry of two-dimensional graphene, which is supported by theoretical simulation using molecular dynamics. Our findings are expected to play a key role in understanding of ripple physics in graphene and other two-dimensional materials.« less

  4. Configuration of ripple domains and their topological defects formed under local mechanical stress on hexagonal monolayer graphene

    SciTech Connect (OSTI)

    Park, Yeonggu; Choi, Jin Sik; Choi, Taekjib; Lee, Mi Jung; Jia, Quanxi; Park, Minwoo; Lee, Hoonkyung; Park, Bae Ho

    2015-03-24

    Ripples in graphene are extensively investigated because they ensure the mechanical stability of two-dimensional graphene and affect its electronic properties. They arise from spontaneous symmetry breaking and are usually manifested in the form of domains with long-range order. It is expected that topological defects accompany a material exhibiting long-range order, whose functionality depends on characteristics of domains and topological defects. However, there remains a lack of understanding regarding ripple domains and their topological defects formed on monolayer graphene. Here we explore configuration of ripple domains and their topological defects in exfoliated monolayer graphenes on SiO?/Si substrates using transverse shear microscope. We observe three-color domains with three different ripple directions, which meet at a core. Furthermore, the closed domain is surrounded by an even number of cores connected together by domain boundaries, similar to topological vortex and anti-vortex pairs. In addition, we have found that axisymmetric three-color domains can be induced around nanoparticles underneath the graphene. This fascinating configuration of ripple domains may result from the intrinsic hexagonal symmetry of two-dimensional graphene, which is supported by theoretical simulation using molecular dynamics. Our findings are expected to play a key role in understanding of ripple physics in graphene and other two-dimensional materials.

  5. Kits and methods of detection using cellulose binding domain fusion proteins

    DOE Patents [OSTI]

    Shoseyov, Oded

    1998-01-01

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.

  6. Kits and methods of detection using cellulose binding domain fusion proteins

    DOE Patents [OSTI]

    Shoseyov, O.; Yosef, K.

    1998-04-14

    A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques. 16 figs.

  7. V-084: RSA Archer eGRC Permits Cross-Site Scripting, Cross-Domain...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    V-084: RSA Archer eGRC Permits Cross-Site Scripting, Cross-Domain Access, Clickjacking, ... The vendor has issued a fix (5.2SP1, 5.3). Addthis Related Articles V-151: RSA Archer eGRC ...

  8. The Structure of the Poxvirus A33 Protein Reveals a Dimer of Unique C-Type Lectin-Like Domains

    SciTech Connect (OSTI)

    Su, Hua-Poo; Singh, Kavita; Gittis, Apostolos G.; Garboczi, David N. (NIH)

    2010-11-03

    The current vaccine against smallpox is an infectious form of vaccinia virus that has significant side effects. Alternative vaccine approaches using recombinant viral proteins are being developed. A target of subunit vaccine strategies is the poxvirus protein A33, a conserved protein in the Chordopoxvirinae subfamily of Poxviridae that is expressed on the outer viral envelope. Here we have determined the structure of the A33 ectodomain of vaccinia virus. The structure revealed C-type lectin-like domains (CTLDs) that occur as dimers in A33 crystals with five different crystal lattices. Comparison of the A33 dimer models shows that the A33 monomers have a degree of flexibility in position within the dimer. Structural comparisons show that the A33 monomer is a close match to the Link module class of CTLDs but that the A33 dimer is most similar to the natural killer (NK)-cell receptor class of CTLDs. Structural data on Link modules and NK-cell receptor-ligand complexes suggest a surface of A33 that could interact with viral or host ligands. The dimer interface is well conserved in all known A33 sequences, indicating an important role for the A33 dimer. The structure indicates how previously described A33 mutations disrupt protein folding and locates the positions of N-linked glycosylations and the epitope of a protective antibody.

  9. Magnetic domain structure and domain-wall energy in UFe{sub 8}Ni{sub 2}Si{sub 2} and UFe{sub 6}Ni{sub 4}Si{sub 2} intermetallic compounds

    SciTech Connect (OSTI)

    Wyslocki, J.J.; Suski, W.; Wochowski, K.

    1994-03-01

    Magnetic domain structures in the UFe{sub 8}Ni{sub 2}Si{sub 2} and UFe{sub 6}Ni{sub 4}Si{sub 2} compounds were studied using the powder pattern method. The domain structure observed is typical for uniaxial materials. The domain-wall energy density {gamma} was determined from the average surface domain width D{sub s} observed on surfaces perpendicular to the easy axis as equal to 16 erg/cm{sup 2} for UFe{sub 8}Ni{sub 2}Si{sub 2} and 10 erg/cm{sup 2} for UFe{sub 6}Ni{sub 4}Si{sub 2}. Moreover, the critical diameter for single domain particle D{sub c} was calculated for the studied compounds.

  10. Temperature dependence of carrier spin polarization determined from current-induced domain wall motion in a Co/Ni nanowire

    SciTech Connect (OSTI)

    Ueda, K.; Koyama, T.; Hiramatsu, R.; Kobayashi, K.; Ono, T.; Chiba, D.; Fukami, S.; Tanigawa, H.; Suzuki, T.; Ohshima, N.; Ishiwata, N.; Nakatani, Y.

    2012-05-14

    We have investigated the temperature dependence of the current-induced magnetic domain wall (DW) motion in a perpendicularly magnetized Co/Ni nanowire at various temperatures and with various applied currents. The carrier spin polarization was estimated from the measured domain wall velocity. We found that it decreased more with increasing temperature from 100 K to 530 K than the saturation magnetization did.

  11. Data encoding based on the shape of the ferroelectric domains produced by a scanning probe microscopy tip

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kalinin, Sergei V

    2015-01-01

    Ferroelectric materials are broadly considered for information storage due to extremely high storage and information processing densities they enable. To date, ferroelectric based data storage has invariably relied on formation of cylindrical domains, allowing for binary information encoding. Here we demonstrate and explore the potential of high-density encoding based on domain morphology. We explore the domain morphogenesis during the tip-induced polarization switching by sequences of positive and negative pulses in a lithium niobate single-crystal and demonstrate the principal of information coding by shape and size of the domains. We applied cross-correlation and neural network approaches for recognition of the switchingmore » sequence by the shape of the resulting domains and establish optimal parameters for domain shape recognition. These studies both provide insight into the highly non-trivial mechanism of domain switching and potentially establish a new paradigm for multilevel information storage and content retrieval memories. Furthermore, this approach opens a pathway to exploration of domain switching mechanisms via shape analysis.« less

  12. Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pin1 WW domain

    SciTech Connect (OSTI)

    Mortenson, David E.; Kreitler, Dale F.; Yun, Hyun Gi; Gellman, Samuel H., E-mail: gellman@chem.wisc.edu; Forest, Katrina T., E-mail: gellman@chem.wisc.edu [University of Wisconsin-Madison, Madison, WI 53706 (United States)

    2013-12-01

    Two structures of a small protein with a defined tertiary fold, the isolated Pin1 WW domain, have been determined via racemic crystallization with small-molecule additives. These additives, which are either racemic or achiral, appear to stabilize a dynamic loop region of the structure. The human Pin1 WW domain is a small autonomously folding protein that has been useful as a model system for biophysical studies of ?-sheet folding. This domain has resisted previous attempts at crystallization for X-ray diffraction studies, perhaps because of intrinsic conformational flexibility that interferes with the formation of a crystal lattice. Here, the crystal structure of the human Pin1 WW domain has been obtained via racemic crystallization in the presence of small-molecule additives. Both enantiomers of a 36-residue variant of the Pin1 WW domain were synthesized chemically, and the l- and d-polypeptides were combined to afford diffracting crystals. The structural data revealed packing interactions of small carboxylic acids, either achiral citrate or a d,l mixture of malic acid, with a mobile loop region of the WW-domain fold. These interactions with solution additives may explain our success in crystallization of this protein racemate. Molecular-dynamics simulations starting from the structure of the Pin1 WW domain suggest that the crystal structure closely resembles the conformation of this domain in solution. The structural data presented here should provide a basis for further studies of this important model system.

  13. Nucleic acid sequences encoding D1 and D1/D2 domains of human coxsackievirus and adenovirus receptor (CAR)

    DOE Patents [OSTI]

    Freimuth, Paul I.

    2010-04-06

    The invention provides recombinant human CAR (coxsackievirus and adenovirus receptor) polypeptides which bind adenovirus. Specifically, polypeptides corresponding to adenovirus binding domain D1 and the entire extracellular domain of human CAR protein comprising D1 and D2 are provided. In another aspect, the invention provides nucleic acid sequences encoding these domains and expression vectors for producing the domains and bacterial cells containing such vectors. The invention also includes an isolated fusion protein comprised of the D1 polypeptide fused to a polypeptide which facilitates folding of D1 when expressed in bacteria. The functional D1 domain finds application in a therapeutic method for treating a patient infected with a CAR D1-binding virus, and also in a method for identifying an antiviral compound which interferes with viral attachment. The invention also provides a method for specifically targeting a cell for infection by a virus which binds to D1.

  14. Fast multiscale Gaussian beam methods for wave equations in bounded convex domains

    SciTech Connect (OSTI)

    Bao, Gang; Department of Mathematics, Michigan State University, East Lansing, MI 48824 ; Lai, Jun; Qian, Jianliang

    2014-03-15

    Motivated by fast multiscale Gaussian wavepacket transforms and multiscale Gaussian beam methods which were originally designed for pure initial-value problems of wave equations, we develop fast multiscale Gaussian beam methods for initial boundary value problems of wave equations in bounded convex domains in the high frequency regime. To compute the wave propagation in bounded convex domains, we have to take into account reflecting multiscale Gaussian beams, which are accomplished by enforcing reflecting boundary conditions during beam propagation and carrying out suitable reflecting beam summation. To propagate multiscale beams efficiently, we prove that the ratio of the squared magnitude of beam amplitude and the beam width is roughly conserved, and accordingly we propose an effective indicator to identify significant beams. We also prove that the resulting multiscale Gaussian beam methods converge asymptotically. Numerical examples demonstrate the accuracy and efficiency of the method.

  15. A Moving Window Technique in Parallel Finite Element Time Domain Electromagnetic Simulation

    SciTech Connect (OSTI)

    Lee, Lie-Quan; Candel, Arno; Ng, Cho; Ko, Kwok; ,

    2010-06-07

    A moving window technique for the finite element time domain (FETD) method is developed to simulate the propagation of electromagnetic waves induced by the transit of a charged particle beam inside large and long structures. The window moving along with the beam in the computational domain adopts high-order finite-element basis functions through p refinement and/or a high-resolution mesh through h refinement so that a sufficient accuracy is attained with substantially reduced computational costs. Algorithms to transfer discretized fields from one mesh to another, which are the key to implementing a moving window in a finite-element unstructured mesh, are presented. Numerical experiments are carried out using the moving window technique to compute short-range wakefields in long accelerator structures. The results are compared with those obtained from the normal FETD method and the advantages of using the moving window technique are discussed.

  16. LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins

    SciTech Connect (OSTI)

    Sosa, Brian A.; Rothballer, Andrea; Kutay, Ulrike; Schwartz, Thomas U.

    2012-08-31

    Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope and are composed of KASH and SUN proteins residing in the outer and inner nuclear membrane, respectively. LINC formation relies on direct binding of KASH and SUN in the perinuclear space. Thereby, molecular tethers are formed that can transmit forces for chromosome movements, nuclear migration, and anchorage. We present crystal structures of the human SUN2-KASH1/2 complex, the core of the LINC complex. The SUN2 domain is rigidly attached to a trimeric coiled coil that prepositions it to bind three KASH peptides. The peptides bind in three deep and expansive grooves formed between adjacent SUN domains, effectively acting as molecular glue. In addition, a disulfide between conserved cysteines on SUN and KASH covalently links both proteins. The structure provides the basis of LINC complex formation and suggests a model for how LINC complexes might arrange into higher-order clusters to enhance force-coupling.

  17. Work Domain Analysis Methodology for Development of Operational Concepts for Advanced Reactors

    SciTech Connect (OSTI)

    Hugo, Jacques

    2015-05-01

    This report describes a methodology to conduct a Work Domain Analysis in preparation for the development of operational concepts for new plants. This method has been adapted from the classical method described in the literature in order to better deal with the uncertainty and incomplete information typical of first-of-a-kind designs. The report outlines the strategy for undertaking a Work Domain Analysis of a new nuclear power plant and the methods to be used in the development of the various phases of the analysis. Basic principles are described to the extent necessary to explain why and how the classical method was adapted to make it suitable as a tool for the preparation of operational concepts for a new nuclear power plant. Practical examples are provided of the systematic application of the method and the various presentation formats in the operational analysis of advanced reactors.

  18. Algebraic multigrid domain and range decomposition (AMG-DD / AMG-RD)*

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bank, R.; Falgout, R. D.; Jones, T.; Manteuffel, T. A.; McCormick, S. F.; Ruge, J. W.

    2015-10-29

    In modern large-scale supercomputing applications, algebraic multigrid (AMG) is a leading choice for solving matrix equations. However, the high cost of communication relative to that of computation is a concern for the scalability of traditional implementations of AMG on emerging architectures. This paper introduces two new algebraic multilevel algorithms, algebraic multigrid domain decomposition (AMG-DD) and algebraic multigrid range decomposition (AMG-RD), that replace traditional AMG V-cycles with a fully overlapping domain decomposition approach. While the methods introduced here are similar in spirit to the geometric methods developed by Brandt and Diskin [Multigrid solvers on decomposed domains, in Domain Decomposition Methods inmore » Science and Engineering, Contemp. Math. 157, AMS, Providence, RI, 1994, pp. 135--155], Mitchell [Electron. Trans. Numer. Anal., 6 (1997), pp. 224--233], and Bank and Holst [SIAM J. Sci. Comput., 22 (2000), pp. 1411--1443], they differ primarily in that they are purely algebraic: AMG-RD and AMG-DD trade communication for computation by forming global composite “grids” based only on the matrix, not the geometry. (As is the usual AMG convention, “grids” here should be taken only in the algebraic sense, regardless of whether or not it corresponds to any geometry.) Another important distinguishing feature of AMG-RD and AMG-DD is their novel residual communication process that enables effective parallel computation on composite grids, avoiding the all-to-all communication costs of the geometric methods. The main purpose of this paper is to study the potential of these two algebraic methods as possible alternatives to existing AMG approaches for future parallel machines. As a result, this paper develops some theoretical properties of these methods and reports on serial numerical tests of their convergence properties over a spectrum of problem parameters.« less

  19. Field-driven Polarization and Domain Dynamics of Ferroelectric/Dielectric

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Superlattices | Stanford Synchrotron Radiation Lightsource Field-driven Polarization and Domain Dynamics of Ferroelectric/Dielectric Superlattices Thursday, March 1, 2012 - 10:00am SSRL Conference Room 137-226 Paul G. Evans, Materials Science and Engineering, University of Wisconsin-Madison The atomic-scale periodicity of ferroelectric/dielectric superlattices leads to an exciting variety of structural and dynamic effects in applied electric fields. The richness of these phenomena arises in

  20. Structure of the Kinase Domain of CaMKII and Modeling the Holoenzyme

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structure of the Kinase Domain of CaMKII and Modeling the Holoenzyme Print The rate and intensity of calcium (Ca2+) currents that oscillate through the plasma membrane around a cell affect such diverse phenomena as fertilization, the cardiac rhythm, and even the formation of memories. How does the cell sense these digital oscillations and transduce them into a cellular signal, such as changes in phosphorylation (addition of a phosphate group to a protein) or gene transcription? A group from the

  1. Algebraic multigrid domain and range decomposition (AMG-DD / AMG-RD)*

    SciTech Connect (OSTI)

    Bank, R.; Falgout, R. D.; Jones, T.; Manteuffel, T. A.; McCormick, S. F.; Ruge, J. W.

    2015-10-29

    In modern large-scale supercomputing applications, algebraic multigrid (AMG) is a leading choice for solving matrix equations. However, the high cost of communication relative to that of computation is a concern for the scalability of traditional implementations of AMG on emerging architectures. This paper introduces two new algebraic multilevel algorithms, algebraic multigrid domain decomposition (AMG-DD) and algebraic multigrid range decomposition (AMG-RD), that replace traditional AMG V-cycles with a fully overlapping domain decomposition approach. While the methods introduced here are similar in spirit to the geometric methods developed by Brandt and Diskin [Multigrid solvers on decomposed domains, in Domain Decomposition Methods in Science and Engineering, Contemp. Math. 157, AMS, Providence, RI, 1994, pp. 135--155], Mitchell [Electron. Trans. Numer. Anal., 6 (1997), pp. 224--233], and Bank and Holst [SIAM J. Sci. Comput., 22 (2000), pp. 1411--1443], they differ primarily in that they are purely algebraic: AMG-RD and AMG-DD trade communication for computation by forming global composite “grids” based only on the matrix, not the geometry. (As is the usual AMG convention, “grids” here should be taken only in the algebraic sense, regardless of whether or not it corresponds to any geometry.) Another important distinguishing feature of AMG-RD and AMG-DD is their novel residual communication process that enables effective parallel computation on composite grids, avoiding the all-to-all communication costs of the geometric methods. The main purpose of this paper is to study the potential of these two algebraic methods as possible alternatives to existing AMG approaches for future parallel machines. As a result, this paper develops some theoretical properties of these methods and reports on serial numerical tests of their convergence properties over a spectrum of problem parameters.

  2. Structure of the Kinase Domain of CaMKII and Modeling the Holoenzyme

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structure of the Kinase Domain of CaMKII and Modeling the Holoenzyme Print The rate and intensity of calcium (Ca2+) currents that oscillate through the plasma membrane around a cell affect such diverse phenomena as fertilization, the cardiac rhythm, and even the formation of memories. How does the cell sense these digital oscillations and transduce them into a cellular signal, such as changes in phosphorylation (addition of a phosphate group to a protein) or gene transcription? A group from the

  3. New Report Shows Trend Toward Larger Offshore Wind Systems, with 11 Advanced Stage Projects Proposed in U.S. Waters

    Broader source: Energy.gov [DOE]

    The Energy Department today released a new report showing progress for the U.S. offshore wind energy market in 2012, including the completion of two commercial lease auctions for federal Wind Energy Areas and 11 commercial-scale U.S. projects repre

  4. Crystal structure of the FLT3 kinase domain bound to the inhibitor quizartinib (AC220)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zorn, Julie A.; Wang, Qi; Fujimura, Eric; Barros, Tiago; Kuriyan, John; Boggon, Titus J.

    2015-04-02

    More than 30% of acute myeloid leukemia (AML) patients possess activating mutations in the receptor tyrosine kinase FMS-like tyrosine kinase 3 or FLT3. A small-molecule inhibitor of FLT3 (known as quizartinib or AC220) that is currently in clinical trials appears promising for the treatment of AML. Here, we report the co-crystal structure of the kinase domain of FLT3 in complex with quizartinib. FLT3 with quizartinib bound adopts an “Abl-like” inactive conformation with the activation loop stabilized in the “DFG-out” orientation and folded back onto the kinase domain. This conformation is similar to that observed for the uncomplexed intracellular domain ofmore » FLT3 as well as for related receptor tyrosine kinases, except for a localized induced fit in the activation loop. The co-crystal structure reveals the interactions between quizartinib and the active site of FLT3 that are key for achieving its high potency against both wild-type FLT3 as well as a FLT3 variant observed in many AML patients. This co-complex further provides a structural rationale for quizartinib-resistance mutations.« less

  5. Crystal structure of the FLT3 kinase domain bound to the inhibitor quizartinib (AC220)

    SciTech Connect (OSTI)

    Zorn, Julie A.; Wang, Qi; Fujimura, Eric; Barros, Tiago; Kuriyan, John; Boggon, Titus J.

    2015-04-02

    More than 30% of acute myeloid leukemia (AML) patients possess activating mutations in the receptor tyrosine kinase FMS-like tyrosine kinase 3 or FLT3. A small-molecule inhibitor of FLT3 (known as quizartinib or AC220) that is currently in clinical trials appears promising for the treatment of AML. Here, we report the co-crystal structure of the kinase domain of FLT3 in complex with quizartinib. FLT3 with quizartinib bound adopts an “Abl-like” inactive conformation with the activation loop stabilized in the “DFG-out” orientation and folded back onto the kinase domain. This conformation is similar to that observed for the uncomplexed intracellular domain of FLT3 as well as for related receptor tyrosine kinases, except for a localized induced fit in the activation loop. The co-crystal structure reveals the interactions between quizartinib and the active site of FLT3 that are key for achieving its high potency against both wild-type FLT3 as well as a FLT3 variant observed in many AML patients. This co-complex further provides a structural rationale for quizartinib-resistance mutations.

  6. Dopant profile modeling by rare event enhanced domain-following molecular dynamics

    DOE Patents [OSTI]

    Beardmore, Keith M.; Jensen, Niels G.

    2002-01-01

    A computer-implemented molecular dynamics-based process simulates a distribution of ions implanted in a semiconductor substrate. The properties of the semiconductor substrate and ion dose to be simulated are first initialized, including an initial set of splitting depths that contain an equal number of virtual ions implanted in each substrate volume determined by the splitting depths. A first ion with selected velocity is input onto an impact position of the substrate that defines a first domain for the first ion during a first timestep, where the first domain includes only those atoms of the substrate that exert a force on the ion. A first position and velocity of the first ion is determined after the first timestep and a second domain of the first ion is formed at the first position. The first ion is split into first and second virtual ions if the first ion has passed through a splitting interval. The process then follows each virtual ion until all of the virtual ions have come to rest. A new ion is input to the surface and the process repeats until all of the ion dose has been input. The resulting ion rest positions form the simulated implant distribution.

  7. An ABCA1 truncation shows no dominant negative effect in a familial hypoalphalipoproteinemia pedigree with three ABCA1 mutations

    SciTech Connect (OSTI)

    Sorrenson, Brie; Suetani, Rachel J.; Bickley, Vivienne M.; George, Peter M.; Williams, Michael J.A.; Scott, Russell S.; McCormick, Sally P.A.

    2011-06-10

    Highlights: {yields} Characterisation of an ABCA1 truncation mutant, C978fsX988, in a pedigree with three ABCA1 mutations. {yields} Functional analysis of C978fsX988 in patient fibroblasts and HEK 293 cells shows no cholesterol efflux function. {yields} Allele-specific quantification shows C978fsX988 not expressed at mRNA level in fibroblasts. {yields} Unlike other ABCA1 truncations, C978fsX988 mutant shows no dominant negative effect at mRNA or protein level. -- Abstract: The ATP binding cassette transporter (ABCA1) A1 is a key determinant of circulating high density lipoprotein cholesterol (HDL-C) levels. Mutations in ABCA1 are a major genetic contributor to low HDL-C levels within the general population. Following the finding of three different ABCA1 mutations, p.C978fsX988, p.T1512M and p.N1800H in a subject with hypoalphalipoproteinemia, we aimed to establish whether the p.C978fsX988 truncation exerted a dominant negative effect on the full-length ABCA1 alleles within family members as has been reported for other ABCA1 truncations. Characterisation of the p.C978fsX988 mutant in transfected HEK 293 cells showed it to be expressed as a GFP fusion protein but lacking in cholesterol efflux function. This was in keeping with results from cholesterol efflux assays in the fibroblasts of p.C978fsX988 carriers which also showed impaired efflux. Allele- specific quantification of p.C978fsX988 mRNA and analysis of ABCA1 protein levels in the fibroblasts of p.C978fsX988 heterozygotes showed negligible levels of mRNA and protein expression. There was no evidence of a dominant negative effect on wildtype or p.N1800H protein levels. We conclude that in the case of the p.C978fsX988 truncated mutant a lack of expression precludes it from having a dominant negative effect.

  8. Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype

    SciTech Connect (OSTI)

    Kaisho, Yoshihiko . E-mail: Kaisho_Yoshihiko@takeda.co.jp; Watanabe, Takuya; Nakata, Mitsugu; Yano, Takashi; Yasuhara, Yoshitaka; Shimakawa, Kozo; Mori, Ikuo; Sakura, Yasufumi; Terao, Yasuko; Matsui, Hideki; Taketomi, Shigehisa

    2005-05-13

    The human MrgX3 gene, belonging to the mrgs/SNSRs (mass related genes/sensory neuron specific receptors) family, was overexpressed in transgenic rats using the actin promoter. Two animal lines showed cataracts with liquification/degeneration and swelling of the lens fiber cells. The transient epidermal desquamation was observed in line with higher gene expression. Histopathology of the transgenic rats showed acanthosis and focal parakeratosis. In the epidermis, there was an increase in cellular keratin 14, keratin 10, and loricrin, as well as PGP 9.5 in innervating nerve fibers. These phenotypes accompanied an increase in the number of proliferating cells. These results suggest that overexpression of the human MrgX3 gene causes a disturbance of the normal cell-differentiation process.

  9. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

    SciTech Connect (OSTI)

    Lin, David Yin-wei; Tanaka, Yoshimasa; Iwasaki, Masashi; Gittis, Apostolos G.; Su, Hua-Poo; Mikami, Bunzo; Okazaki, Taku; Honjo, Tasuku; Minato, Nagahiro; Garboczi, David N. (NIH); (Kyoto)

    2008-07-29

    Signaling through the programmed death 1 (PD-1) inhibitory receptor upon binding its ligand, PD-L1, suppresses immune responses against autoantigens and tumors and plays an important role in the maintenance of peripheral immune tolerance. Release from PD-1 inhibitory signaling revives 'exhausted' virus-specific T cells in chronic viral infections. Here we present the crystal structure of murine PD-1 in complex with human PD-L1. PD-1 and PD-L1 interact through the conserved front and side of their Ig variable (IgV) domains, as do the IgV domains of antibodies and T cell receptors. This places the loops at the ends of the IgV domains on the same side of the PD-1/PD-L1 complex, forming a surface that is similar to the antigen-binding surface of antibodies and T cell receptors. Mapping conserved residues allowed the identification of residues that are important in forming the PD-1/PD-L1 interface. Based on the structure, we show that some reported loss-of-binding mutations involve the PD-1/PD-L1 interaction but that others compromise protein folding. The PD-1/PD-L1 interaction described here may be blocked by antibodies or by designed small-molecule drugs to lower inhibitory signaling that results in a stronger immune response. The immune receptor-like loops offer a new surface for further study and potentially the design of molecules that would affect PD-1/PD-L1 complex formation and thereby modulate the immune response.

  10. f{sub K}/f{sub {pi}} in full QCD with domain wall valence quarks (Journal

    Office of Scientific and Technical Information (OSTI)

    Article) | SciTech Connect f{sub K}/f{sub {pi}} in full QCD with domain wall valence quarks Citation Details In-Document Search Title: f{sub K}/f{sub {pi}} in full QCD with domain wall valence quarks We compute the ratio of pseudoscalar decay constants f{sub K}/f{sub {pi}} using domain-wall valence quarks and rooted improved Kogut-Susskind sea quarks, at a lattice spacing of b{approx}0.125 fm. By employing continuum chiral perturbation theory, we extract the Gasser-Leutwyler low-energy

  11. DES14X3taz: A type I superluminous supernova showing a luminous, rapidly cooling initial pre-peak bump

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Smith, M.

    2016-02-03

    Here, we present DES14X3taz, a new hydrogen-poor superluminous supernova (SLSN-I) discovered by the Dark Energy Survey (DES) supernova program, with additional photometric data provided by the Survey Using DECam for Superluminous Supernovae. Spectra obtained using Optical System for Imaging and low-Intermediate-Resolution Integrated Spectroscopy on the Gran Telescopio CANARIAS show DES14X3taz is an SLSN-I at z = 0.608. Multi-color photometry reveals a double-peaked light curve: a blue and relatively bright initial peak that fades rapidly prior to the slower rise of the main light curve. Our multi-color photometry allows us, for the first time, to show that the initial peak cools from 22,000more » to 8000 K over 15 rest-frame days, and is faster and brighter than any published core-collapse supernova, reaching 30% of the bolometric luminosity of the main peak. No physical (56)Ni-powered model can fit this initial peak. We show that a shock-cooling model followed by a magnetar driving the second phase of the light curve can adequately explain the entire light curve of DES14X3taz. Models involving the shock-cooling of extended circumstellar material at a distance of ≃400 R⊙ are preferred over the cooling of shock-heated surface layers of a stellar envelope. We compare DES14X3taz to the few double-peaked SLSN-I events in the literature. Although the rise times and characteristics of these initial peaks differ, there exists the tantalizing possibility that they can be explained by one physical interpretation.« less

  12. igure 1. Map of N. Alaska and NW Canada Showing the Locations of the NPR-A,

    U.S. Energy Information Administration (EIA) Indexed Site

    ANWR, 1002 Area, Current Productive Area, and TAPS 1. Map of Northern Alaska and Northwestern Canada Showing the Locations of the National Petroleum Reserve-Alaska (NPR-A), Arctic National Wildlife Refuge (ANWR), 1002 Area, Current Productive Area, and Trans-Alaska Pipeline System (TAPS) fig1.jpg (122614 bytes) Source: Edited from U.S. Geological Survey, "The Oil and Gas Resource Potential of the Arctic National Wildlife Refuge 1002 Area, Alaska," Open File Report 98-34, 1999.

  13. Primary explants of human uroepithelium show an unusual response to low-dose irradiation with cobalt-60 gamma rays

    SciTech Connect (OSTI)

    Mothersill, C.; Seymour, C.B.; Harney, J.; Parsons, K.; Lyng, F.; Cottell, D.; Murphy, D.M.

    1995-05-01

    Recent results using very low doses of radiation have suggested that there is a hypersensitive region where cultures show an enhanced level of cell killing leading to a non-monotonic survival curve. This effect has been observed at doses below 2 Gy in mammalian systems and at much higher doses in insect cells. In this paper we report observation of the effect in primary human uroepithelial cell cultures. The effect was measured using a postirradiation proliferation assay where irradiated explants of standard size were allowed to proliferate for 14 days after exposure to {sup 60}Co{gamma} irradiation. By 14 days the majority of cultures derived from explants irradiated with 2-5 Gy showed little evidence of growth inhibition and cell numbers approached or even exceeded those obtained in the controls. There was, however, a significant reduction in cell number and growth rate in all cultures exposed to doses lower than 1 Gy. Oncoprotein and EGFR expression were also measured in these cultures and were significantly increased. Morphological evidence of apoptosis was present in all irradiated cultures at 4 h after exposure, but this persisted for longer periods in cultures exposed to low doses. 18 refs., 2 figs., 4 tabs.

  14. Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies

    DOE Patents [OSTI]

    Tromberg, Bruce J.; Berger, Andrew J.; Cerussi, Albert E.; Bevilacqua, Frederic; Jakubowski, Dorota

    2008-09-23

    A technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frequency-domain and steady-state reflectance methods. Most of the wavelength coverage is provided by a white-light steady-state measurement, whereas the frequency-domain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequency-domain data are used to calibrate the intensity of the steady-state measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steady-state reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequency-domain and steady-state technique, agree well with expected reference values.

  15. A portable time-domain LED fluorimeter for nanosecond fluorescence lifetime measurements

    SciTech Connect (OSTI)

    Wang, Hongtao; Salthouse, Christopher D.; Qi, Ying; Mountziaris, T. J.; Chemical Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003

    2014-05-15

    Fluorescence lifetime measurements are becoming increasingly important in chemical and biological research. Time-domain lifetime measurements offer fluorescence multiplexing and improved handling of interferers compared with the frequency-domain technique. In this paper, an all solid-state, filterless, and highly portable light-emitting-diode based time-domain fluorimeter (LED TDF) is reported for the measurement of nanosecond fluorescence lifetimes. LED based excitation provides more wavelengths options compared to laser diode based excitation, but the excitation is less effective due to the uncollimated beam, less optical power, and longer latency in state transition. Pulse triggering and pre-bias techniques were implemented in our LED TDF to improve the peak optical power to over 100 mW. The proposed pulsing circuit achieved an excitation light fall time of less than 2 ns. Electrical resetting technique realized a time-gated photo-detector to remove the interference of the excitation light with fluorescence. These techniques allow the LED fluorimeter to accurately measure the fluorescence lifetime of fluorescein down to concentration of 0.5 μM. In addition, all filters required in traditional instruments are eliminated for the non-attenuated excitation/emission light power. These achievements make the reported device attractive to biochemical laboratories seeking for highly portable lifetime detection devices for developing sensors based on fluorescence lifetime changes. The device was initially validated by measuring the lifetimes of three commercial fluorophores and comparing them with reported lifetime data. It was subsequently used to characterize a ZnSe quantum dot based DNA sensor.

  16. Ferroelasticity and domain physics in two-dimensional transition metal dichalcogenide monolayers

    Office of Scientific and Technical Information (OSTI)

    3 Sep 2015 | Accepted 27 Jan 2016 | Published 24 Feb 2016 DOI: 10.1038/ncomms10843 Ferroelasticity and domain physics in two-dimensional transition metal dichalcogenide monolayers OPEN Wenbin Li1 & Ju Li2 Monolayers of transition metal dichalcogenides can exist in several structural polymorphs, including 2H, 1Tand 1T'. The low-symmetry 1T phase has three orientation variants, resulting from the three equivalent directions of Peierls distortion in the parental 1T phase. Using first-principles

  17. Remarks on Hierarchic Control for a Linearized Micropolar Fluids System in Moving Domains

    SciTech Connect (OSTI)

    Jesus, Isaías Pereira de

    2015-12-15

    We study a Stackelberg strategy subject to the evolutionary linearized micropolar fluids equations in domains with moving boundaries, considering a Nash multi-objective equilibrium (non necessarily cooperative) for the “follower players” (as is called in the economy field) and an optimal problem for the leader player with approximate controllability objective. We will obtain the following main results: the existence and uniqueness of Nash equilibrium and its characterization, the approximate controllability of the linearized micropolar system with respect to the leader control and the existence and uniqueness of the Stackelberg–Nash problem, where the optimality system for the leader is given.

  18. Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vortices Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic Vortices Print Soft magnetic, micron-sized thin-film structures with magnetic vortices are intriguing systems that may one day be used in ultrafast computer memories. In such systems, the otherwise in-plane magnetization turns perpendicular to the plane at the center of the vortex, forming the vortex core. Because such a core has two possible polarizations (up or down) and can be switched between these two states

  19. Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vortices Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic Vortices Print Soft magnetic, micron-sized thin-film structures with magnetic vortices are intriguing systems that may one day be used in ultrafast computer memories. In such systems, the otherwise in-plane magnetization turns perpendicular to the plane at the center of the vortex, forming the vortex core. Because such a core has two possible polarizations (up or down) and can be switched between these two states

  20. Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vortices Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic Vortices Print Soft magnetic, micron-sized thin-film structures with magnetic vortices are intriguing systems that may one day be used in ultrafast computer memories. In such systems, the otherwise in-plane magnetization turns perpendicular to the plane at the center of the vortex, forming the vortex core. Because such a core has two possible polarizations (up or down) and can be switched between these two states

  1. Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vortices Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic Vortices Print Soft magnetic, micron-sized thin-film structures with magnetic vortices are intriguing systems that may one day be used in ultrafast computer memories. In such systems, the otherwise in-plane magnetization turns perpendicular to the plane at the center of the vortex, forming the vortex core. Because such a core has two possible polarizations (up or down) and can be switched between these two states

  2. rbstmultiprince.f; Equivalent Dipole Polarizability Inversion of Time Domain Electromagnetic Induction Data

    Energy Science and Technology Software Center (OSTI)

    2006-10-01

    This software, rbstmultiprince.f, computes polarizations and positions from electromagnetic data and is used in conjunction with technology to detect UXO. This software was funded by the ESTCP program of the DoD. This code makes use of third party code from the 1970s and 1980s that appears to have entered the public domain and is available for free download via the website netlib.org. The code was first developed by the author while he was employed atmore » UCB and funded by the SERDP of the U.S. Army.« less

  3. High-resolution retinal imaging using adaptive optics and Fourier-domain optical coherence tomography

    DOE Patents [OSTI]

    Olivier, Scot S.; Werner, John S.; Zawadzki, Robert J.; Laut, Sophie P.; Jones, Steven M.

    2010-09-07

    This invention permits retinal images to be acquired at high speed and with unprecedented resolution in three dimensions (4.times.4.times.6 .mu.m). The instrument achieves high lateral resolution by using adaptive optics to correct optical aberrations of the human eye in real time. High axial resolution and high speed are made possible by the use of Fourier-domain optical coherence tomography. Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

  4. Axial couplings of heavy hadrons from domain-wall lattice QCD

    SciTech Connect (OSTI)

    W. Detmold, C.J.D. Lin, S. Meinel

    2011-12-01

    We calculate matrix elements of the axial current for static-light mesons and baryons in lattice QCD with dynamical domain wall fermions. We use partially quenched heavy hadron chiral perturbation theory in a finite volume to extract the axial couplings g{sub 1}, g{sub 2}, and g{sub 3} from the data. These axial couplings allow the prediction of strong decay rates and enter chiral extrapolations of most lattice results in the b sector. Our calculations are performed with two lattice spacings and with pion masses down to 227 MeV.

  5. Final Technical Report - Integrated Hydrogeophysical and Hydrogeologic Driven Parameter Upscaling for Dual-Domain Transport Modeling

    SciTech Connect (OSTI)

    Shafer, John M

    2012-11-05

    The three major components of this research were: 1. Application of minimally invasive, cost effective hydrogeophysical techniques (surface and borehole), to generate fine scale (~1m or less) 3D estimates of subsurface heterogeneity. Heterogeneity is defined as spatial variability in hydraulic conductivity and/or hydrolithologic zones. 2. Integration of the fine scale characterization of hydrogeologic parameters with the hydrogeologic facies to upscale the finer scale assessment of heterogeneity to field scale. 3. Determination of the relationship between dual-domain parameters and practical characterization data.

  6. Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vortices Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic Vortices Print Soft magnetic, micron-sized thin-film structures with magnetic vortices are intriguing systems that may one day be used in ultrafast computer memories. In such systems, the otherwise in-plane magnetization turns perpendicular to the plane at the center of the vortex, forming the vortex core. Because such a core has two possible polarizations (up or down) and can be switched between these two states

  7. Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vortices Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic Vortices Print Soft magnetic, micron-sized thin-film structures with magnetic vortices are intriguing systems that may one day be used in ultrafast computer memories. In such systems, the otherwise in-plane magnetization turns perpendicular to the plane at the center of the vortex, forming the vortex core. Because such a core has two possible polarizations (up or down) and can be switched between these two states

  8. Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vortices Influence of Domain Wall Pinning on the Dynamic Behavior of Magnetic Vortices Print Soft magnetic, micron-sized thin-film structures with magnetic vortices are intriguing systems that may one day be used in ultrafast computer memories. In such systems, the otherwise in-plane magnetization turns perpendicular to the plane at the center of the vortex, forming the vortex core. Because such a core has two possible polarizations (up or down) and can be switched between these two states

  9. Method and apparatus for monitoring the integrity of a geomembrane liner using time domain reflectometry

    DOE Patents [OSTI]

    Morrison, John L.

    2001-04-24

    Leaks are detected in a multi-layered geomembrane liner by a two-dimensional time domain reflectometry (TDR) technique. The TDR geomembrane liner is constructed with an electrically conductive detection layer positioned between two electrically non-conductive dielectric layers, which are each positioned between the detection layer and an electrically conductive reference layer. The integrity of the TDR geomembrane liner is determined by generating electrical pulses within the detection layer and measuring the time delay for any reflected electrical energy caused by absorption of moisture by a dielectric layer.

  10. Protein superfamily members as targets for computer modeling: The carbohydrate recognition domain of a macrophage lectin

    SciTech Connect (OSTI)

    Stenkamp, R.E.; Aruffo, A.; Bajorath, J.

    1996-12-31

    Members of protein superfamilies display similar folds, but share only limited sequence identity, often 25% or less. Thus, it is not straightforward to apply standard homology modeling methods to construct reliable three-dimensional models of such proteins. A three-dimensional model of the carbohydrate recognition domain of the rat macrophage lectin, a member of the calcium-dependent (C-type) lectin superfamily, has been generated to illustrate how information provided by comparison of X-ray structures and sequence-structure alignments can aid in comparative modeling when primary sequence similarities are low. 20 refs., 4 figs.

  11. The RNA recognition motif domains of RBM5 are required for RNA binding and cancer cell proliferation inhibition

    SciTech Connect (OSTI)

    Zhang, Lei; Zhang, Qing; Yang, Yu; Wu, Chuanfang

    2014-02-14

    Highlights: • RNA recognition motif domains of RBM5 are essential for cell proliferation inhibition. • RNA recognition motif domains of RBM5 are essential for apoptosis induction. • RNA recognition motif domains of RBM5 are essential for RNA binding. • RNA recognition motif domains of RBM5 are essential for caspase-2 alternative splicing. - Abstract: RBM5 is a known putative tumor suppressor gene that has been shown to function in cell growth inhibition by modulating apoptosis. RBM5 also plays a critical role in alternative splicing as an RNA binding protein. However, it is still unclear which domains of RBM5 are required for RNA binding and related functional activities. We hypothesized the two putative RNA recognition motif (RRM) domains of RBM5 spanning from amino acids 98–178 and 231–315 are essential for RBM5-mediated cell growth inhibition, apoptosis regulation, and RNA binding. To investigate this hypothesis, we evaluated the activities of the wide-type and mutant RBM5 gene transfer in low-RBM5 expressing A549 cells. We found that, unlike wild-type RBM5 (RBM5-wt), a RBM5 mutant lacking the two RRM domains (RBM5-ΔRRM), is unable to bind RNA, has compromised caspase-2 alternative splicing activity, lacks cell proliferation inhibition and apoptosis induction function in A549 cells. These data provide direct evidence that the two RRM domains of RBM5 are required for RNA binding and the RNA binding activity of RBM5 contributes to its function on apoptosis induction and cell growth inhibition.

  12. Coordinated Multi-layer Multi-domain Optical Network (COMMON) for Large-Scale Science Applications (COMMON)

    SciTech Connect (OSTI)

    Vokkarane, Vinod

    2013-09-01

    We intend to implement a Coordinated Multi-layer Multi-domain Optical Network (COMMON) Framework for Large-scale Science Applications. In the COMMON project, specific problems to be addressed include 1) anycast/multicast/manycast request provisioning, 2) deployable OSCARS enhancements, 3) multi-layer, multi-domain quality of service (QoS), and 4) multi-layer, multidomain path survivability. In what follows, we outline the progress in the above categories (Year 1, 2, and 3 deliverables).

  13. Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface

    SciTech Connect (OSTI)

    Zhang, Rong; Li, Xiaofeng; Boggon, Titus J.

    2015-10-14

    Cerebral cavernous malformations (CCM) are vascular dysplasias that usually occur in the brain and are associated with mutations in the KRIT1/CCM1, CCM2/MGC4607/OSM/Malcavernin, and PDCD10/CCM3/ TFAR15 genes. Here we report the 2.9 Å crystal structure of the ankyrin repeat domain (ARD) and FERM domain of the protein product of KRIT1 (KRIT1; Krev interaction trapped 1). The crystal structure reveals that the KRIT1 ARD contains 4 ankyrin repeats. There is also an unusual conformation in the ANK4 repeat that is stabilized by Trp-404, and the structure reveals a solvent exposed ankyrin groove. Domain orientations of the three copies within the asymmetric unit suggest a stable interaction between KRIT1 ARD and FERM domains, indicating a globular ARD–FERM module. It resembles the additional F0 domain found N-terminal to the FERM domain of talin. Structural analysis of KRIT1 ARD–FERM highlights surface regions of high evolutionary conservation, and suggests potential sites that could mediate interaction with binding partners. The structure therefore provides a better understanding of KRIT1 at the molecular level.

  14. The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster

    SciTech Connect (OSTI)

    Mann, Greg; Koehnke, Jesko; Bent, Andrew F.; Graham, Rachael; Houssen, Wael; Jaspars, Marcel; Schwarz-Linek, Uli; Naismith, James H.

    2014-11-14

    The highly conserved domain of unknown function in the cyanobactin superfamily has a novel fold. The protein does not appear to bind the most plausible substrates, leaving questions as to its role. Patellamides are members of the cyanobactin family of ribosomally synthesized and post-translationally modified cyclic peptide natural products, many of which, including some patellamides, are biologically active. A detailed mechanistic understanding of the biosynthetic pathway would enable the construction of a biotechnological toolkit to make novel analogues of patellamides that are not found in nature. All but two of the protein domains involved in patellamide biosynthesis have been characterized. The two domains of unknown function (DUFs) are homologous to each other and are found at the C-termini of the multi-domain proteins PatA and PatG. The domain sequence is found in all cyanobactin-biosynthetic pathways characterized to date, implying a functional role in cyanobactin biosynthesis. Here, the crystal structure of the PatG DUF domain is reported and its binding interactions with plausible substrates are investigated.

  15. X-ray survival characteristics and genetic analysis for nine saccharomyces deletion mutants that show altered radiation sensitivity

    SciTech Connect (OSTI)

    Game, John C.; Williamson, Marsha S.; Baccari, Clelia

    2004-01-07

    The availability of a genome-wide set of Saccharomyces deletion mutants provides a chance to identify all the yeast genes involved in DNA repair. Using X-rays, we are screening these mutants to identify additional genes that show increased sensitivity to the lethal effects of ionizing radiation. For each mutant identified as sensitive, we are confirming that the sensitivity phenotype co-segregates with the deletion allele and are obtaining multipoint survival-versus-dose assays in at least two haploid and one homozygous diploid strains. We present data for deletion mutants involving the genes DOT1, MDM20, NAT3, SPT7, SPT20, GCN5, HFI1, DCC1 and VID21/EAF1, and discuss their potential roles in repair. Eight of these genes have a clear radiation-sensitive phenotype when deleted, but the ninth, GCN5, has at most a borderline phenotype. None of the deletions confer substantial sensitivity to ultra-violet radiation, although one or two may confer marginal sensitivity. The DOT1 gene is of interest because its only known function is to methylate one lysine residue in the core of the histone H3 protein. We find that histone H3 mutants (supplied by K. Struhl) in which this residue is replaced by other amino-acids are also X-ray sensitive, seeming to confirm that methylation of the lysine-79 residue is required for effective repair of radiation damage.

  16. Fourier Transform Infrared Imaging Showing Reduced Unsaturated Lipid Content in the Hippocampus of a mouse Model of Alzheimer's Disease

    SciTech Connect (OSTI)

    Leskovjan, A.C.; Kretlow, A.; Miller, L.M.

    2010-04-01

    Polyunsaturated fatty acids are essential to brain functions such as membrane fluidity, signal transduction, and cell survival. It is also thought that low levels of unsaturated lipid in the brain may contribute to Alzheimer's disease (AD) risk or severity. However, it is not known how accumulation of unsaturated lipids is affected in different regions of the hippocampus, which is a central target of AD plaque pathology, during aging. In this study, we used Fourier transform infrared imaging (FTIRI) to visualize the unsaturated lipid content in specific regions of the hippocampus in the PSAPP mouse model of AD as a function of plaque formation. Specifically, the unsaturated lipid content was imaged using the olefinic {double_bond}CH stretching mode at 3012 cm{sup -1}. The axonal, dendritic, and somatic layers of the hippocampus were examined in the mice at 13, 24, 40, and 56 weeks old. Results showed that lipid unsaturation in the axonal layer was significantly increased with normal aging in control (CNT) mice (p < 0.01) but remained low and relatively constant in PSAPP mice. Thus, these findings indicate that unsaturated lipid content is reduced in hippocampal white matter during amyloid pathogenesis and that maintaining unsaturated lipid content early in the disease may be critical in avoiding progression of the disease.

  17. Development of time-domain differential Raman for transient thermal probing of materials

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xu, Shen; Wang, Tianyu; Hurley, David; Yue, Yanan; Wang, Xinwei

    2015-01-01

    A novel transient thermal characterization technology is developed based on the principles of transient optical heating and Raman probing: time-domain differential Raman. It employs a square-wave modulated laser of varying duty cycle to realize controlled heating and transient thermal probing. Very well defined extension of the heating time in each measurement changes the temperature evolution profile and the probed temperature field at ?s resolution. Using this new technique, the transient thermal response of a tipless Si cantilever is investigated along the length direction. A physical model is developed to reconstruct the Raman spectrum considering the temperature evolution, while taking intomoreaccount the temperature dependence of the Raman emission. By fitting the variation of the normalized Raman peak intensity, wavenumber, and peak area against the heating time, the thermal diffusivity is determined as 9.17 10??, 8.14 10??, and 9.51 10?? m/s. These results agree well with the reference value of 8.66 10?? m/s considering the 10% fitting uncertainty. The time-domain differential Raman provides a novel way to introduce transient thermal excitation of materials, probe the thermal response, and measure the thermal diffusivity, all with high accuracy.less

  18. Cosmic bubble and domain wall instabilities II: fracturing of colliding walls

    SciTech Connect (OSTI)

    Braden, Jonathan; Bond, J. Richard; Mersini-Houghton, Laura

    2015-08-26

    We study collisions between nearly planar domain walls including the effects of small initial nonplanar fluctuations. These perturbations represent the small fluctuations that must exist in a quantum treatment of the problem. In a previous paper, we demonstrated that at the linear level a subset of these fluctuations experience parametric amplification as a result of their coupling to the planar symmetric background. Here we study the full three-dimensional nonlinear dynamics using lattice simulations, including both the early time regime when the fluctuations are well described by linear perturbation theory as well as the subsequent stage of fully nonlinear evolution. We find that the nonplanar fluctuations have a dramatic effect on the overall evolution of the system. Specifically, once these fluctuations begin to interact nonlinearly the split into a planar symmetric part of the field and the nonplanar fluctuations loses its utility. At this point the colliding domain walls dissolve, with the endpoint of this being the creation of a population of oscillons in the collision region. The original (nearly) planar symmetry has been completely destroyed at this point and an accurate study of the system requires the full three-dimensional simulation.

  19. Fast strain wave induced magnetization changes in long cobalt bars: Domain motion versus coherent rotation

    SciTech Connect (OSTI)

    Davis, S.; Adenwalla, S.; Borchers, J. A.; Maranville, B. B.

    2015-02-14

    A high frequency (88 MHz) traveling strain wave on a piezoelectric substrate is shown to change the magnetization direction in 40 μm wide Co bars with an aspect ratio of 10{sup 3}. The rapidly alternating strain wave rotates the magnetization away from the long axis into the short axis direction, via magnetoelastic coupling. Strain-induced magnetization changes have previously been demonstrated in ferroelectric/ferromagnetic heterostructures, with excellent fidelity between the ferromagnet and the ferroelectric domains, but these experiments were limited to essentially dc frequencies. Both magneto-optical Kerr effect and polarized neutron reflectivity confirm that the traveling strain wave does rotate the magnetization away from the long axis direction and both yield quantitatively similar values for the rotated magnetization. An investigation of the behavior of short axis magnetization with increasing strain wave amplitude on a series of samples with variable edge roughness suggests that the magnetization reorientation that is seen proceeds solely via coherent rotation. Polarized neutron reflectivity data provide direct experimental evidence for this model. This is consistent with expectations that domain wall motion cannot track the rapidly varying strain.

  20. Spatially Resolved Mapping of Electrical Conductivity around Individual Domain (Grain) Boundaries in Graphene

    SciTech Connect (OSTI)

    Li, An-Ping [ORNL; Clark, Kendal W [ORNL; Zhang, Xiaoguang [ORNL; Vlassiouk, Ivan V [ORNL; He, Guowei [Carnegie Mellon University (CMU); Feenstra, Randall [Carnegie Mellon University (CMU)

    2013-01-01

    Graphene films can now be produced on the scale of up to meters. However, all large-scale graphene films contain topological defects that can significantly affect the characteristic transport behaviors of graphene. Here, we spatially map the structures and electronic transport near specific domain and grain boundaries in graphene, and evaluate effects of different types of defect on the electronic conductivity in epitaxial graphene grown on SiC and CVD graphene on Cu subsequently transferred to a SiO2 substrate. We use a combined approach with a multi-probe scanning tunneling potentiometry to investigate both structures and transport at individual grain boundaries and domain boundaries that are defined by coalesced grains, surface steps, and changes in layer thickness. It is found that the substrate step on SiC presents a significant potential barrier for electron transport of epitaxial graphene due to the reduced charge transport from the substrate at the step edges, monolayer-bilayer boundaries exhibit a high resistivity that can change depending on directions of the current across the boundary, and the resistivity of grain boundaries changes with the transition width of the disordered region between two adjacent grains in graphene. The detailed understanding of graphene defects will provide the feedback for controlled engineering of defects in large-scale graphene films.