National Library of Energy BETA

Sample records for distinct population segment

  1. Distinctive manifestations of segmental motion in amorphous poly(tetrahydrofuran) and polyisobutylene

    SciTech Connect (OSTI)

    Santangelo, P.G.; Ngai, K.L.; Roland, C.M. )

    1993-05-24

    Polyisobutylene (PIB) and poly(tetrahydrofuran) (PTHF) exhibit segmental relaxation behavior that is distinctly different from that found for other amorphous polymers. These unusual properties include a segmental relaxation dispersion that is much broader when measured mechanically than as seen by other spectroscopic techniques, a relative insensitivity of the segmental relaxation time to temperature, a small steepness index, and an absence of encroachment of the segmental modes in time scale toward the Rouse region as temperature is lowered. It is proposed herein that these phenomena are the result of the very low extent to which segmental relaxation in PIB and PTHF is constrained by nonbonded neighboring segments. This weak intermolecular coupling, deduced from quasi-elastic neutron scattering measurements, solid-state NMR spectroscopy, and the temperature dependence of the segmental relaxation time, arises from the smooth, symmetric, and flexible structure of the two polymers.

  2. Tailored Marketing for Low-income and Under-Represented Population Segments (201)

    Broader source: Energy.gov [DOE]

    Better Buildings Residential Network Peer Exchange Call Series: Tailored Marketing for Low-Income and Under-Represented Population Segments (201), call slides and discussion summary.

  3. Segmenting CT prostate images using population and patient-specific statistics for radiotherapy

    SciTech Connect (OSTI)

    Feng, Qianjin; Foskey, Mark; Chen Wufan; Shen Dinggang

    2010-08-15

    Purpose: In the segmentation of sequential treatment-time CT prostate images acquired in image-guided radiotherapy, accurately capturing the intrapatient variation of the patient under therapy is more important than capturing interpatient variation. However, using the traditional deformable-model-based segmentation methods, it is difficult to capture intrapatient variation when the number of samples from the same patient is limited. This article presents a new deformable model, designed specifically for segmenting sequential CT images of the prostate, which leverages both population and patient-specific statistics to accurately capture the intrapatient variation of the patient under therapy. Methods: The novelty of the proposed method is twofold: First, a weighted combination of gradient and probability distribution function (PDF) features is used to build the appearance model to guide model deformation. The strengths of each feature type are emphasized by dynamically adjusting the weight between the profile-based gradient features and the local-region-based PDF features during the optimization process. An additional novel aspect of the gradient-based features is that, to alleviate the effect of feature inconsistency in the regions of gas and bone adjacent to the prostate, the optimal profile length at each landmark is calculated by statistically investigating the intensity profile in the training set. The resulting gradient-PDF combined feature produces more accurate and robust segmentations than general gradient features. Second, an online learning mechanism is used to build shape and appearance statistics for accurately capturing intrapatient variation. Results: The performance of the proposed method was evaluated on 306 images of the 24 patients. Compared to traditional gradient features, the proposed gradient-PDF combination features brought 5.2% increment in the success ratio of segmentation (from 94.1% to 99.3%). To evaluate the effectiveness of online

  4. TWO DISTINCT RED GIANT BRANCH POPULATIONS IN THE GLOBULAR CLUSTER NGC 2419 AS TRACERS OF A MERGER EVENT IN THE MILKY WAY

    SciTech Connect (OSTI)

    Lee, Young-Wook; Han, Sang-Il; Joo, Seok-Joo; Jang, Sohee; Na, Chongsam; Lim, Dongwook; Kim, Hak-Sub; Yoon, Suk-Jin; Okamoto, Sakurako; Arimoto, Nobuo

    2013-11-20

    Recent spectroscopic observations of the outer halo globular cluster (GC) NGC 2419 show that it is unique among GCs, in terms of chemical abundance patterns, and some suggest that it was originated in the nucleus of a dwarf galaxy. Here we show, from the Subaru narrowband photometry employing a calcium filter, that the red giant branch (RGB) of this GC is split into two distinct subpopulations. Comparison with spectroscopy has confirmed that the redder RGB stars in the hk[=(Ca–b) – (b – y)] index are enhanced in [Ca/H] by ∼0.2 dex compared to the bluer RGB stars. Our population model further indicates that the calcium-rich second generation stars are also enhanced in helium abundance by a large amount (ΔY = 0.19). Our photometry, together with the results for other massive GCs (e.g., ω Cen, M22, and NGC 1851), suggests that the discrete distribution of RGB stars in the hk index might be a universal characteristic of this growing group of peculiar GCs. The planned narrowband calcium photometry for the Local Group dwarf galaxies would help to establish an empirical connection between these GCs and the primordial building blocks in the hierarchical merging paradigm of galaxy formation.

  5. Residential Segmentation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (PDF, 96 pages) Sub-regional overviews and segment personalizations, including demographics, attributes and other information specific to each sub-region. View the reports for...

  6. Tailored Marketing for Low-income and Under-Represented Population...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Tailored Marketing for Low-income and Under-Represented Population Segments (201) Tailored Marketing for Low-income and Under-Represented Population Segments (201) Better Buildings ...

  7. Duplication of coding segments in genetic programming

    SciTech Connect (OSTI)

    Haynes, T.

    1996-12-31

    Research into the utility of non-coding segments, or introns, in genetic-based encodings has shown that they expedite the evolution of solutions in domains by protecting building blocks against destructive crossover. We consider a genetic programming system where non-coding segments can be removed, and the resultant chromosomes returned into the population. This parsimonious repair leads to premature convergence, since as we remove the naturally occurring non-coding segments, we strip away their protective backup feature. We then duplicate the coding segments in the repaired chromosomes, and place the modified chromosomes into the population. The duplication method significantly improves the learning rate in the domain we have considered. We also show that this method can be applied to other domains.

  8. Solar Distinction | Open Energy Information

    Open Energy Info (EERE)

    Distinction Jump to: navigation, search Name: Solar Distinction Place: Albuquerque, New Mexico Product: New Mexico-based PV module maker. References: Solar Distinction1 This...

  9. Parallel grid population

    DOE Patents [OSTI]

    Wald, Ingo; Ize, Santiago

    2015-07-28

    Parallel population of a grid with a plurality of objects using a plurality of processors. One example embodiment is a method for parallel population of a grid with a plurality of objects using a plurality of processors. The method includes a first act of dividing a grid into n distinct grid portions, where n is the number of processors available for populating the grid. The method also includes acts of dividing a plurality of objects into n distinct sets of objects, assigning a distinct set of objects to each processor such that each processor determines by which distinct grid portion(s) each object in its distinct set of objects is at least partially bounded, and assigning a distinct grid portion to each processor such that each processor populates its distinct grid portion with any objects that were previously determined to be at least partially bounded by its distinct grid portion.

  10. A WFC3/HST VIEW OF THE THREE STELLAR POPULATIONS IN THE GLOBULAR CLUSTER NGC 6752

    SciTech Connect (OSTI)

    Milone, A. P.; Marino, A. F.; Yong, D. E-mail: amarino@mso.anu.edu.au; and others

    2013-04-20

    Multi-band Hubble Space Telescope photometry reveals that the main sequence, sub-giant, and the red-giant branch of the globular cluster NGC 6752 splits into three main components in close analogy with the three distinct segments along its horizontal branch stars. These triple sequences are consistent with three stellar groups: a stellar population with a chemical composition similar to field-halo stars (Population a), a Population (c) with enhanced sodium and nitrogen, depleted carbon and oxygen, and an enhanced helium abundance ({Delta}Y {approx} 0.03), and a Population (b) with an intermediate (between Populations a and c) chemical composition and slightly enhanced helium ({Delta}Y {approx} 0.01). These components contain {approx}25% (Population a), {approx}45% (Population b), and {approx}30% (Population c) of the stars. No radial gradient for the relative numbers of the three populations has been identified out to about 2.5 half-mass radii.

  11. Impact assisted segmented cutterhead

    DOE Patents [OSTI]

    Morrell, Roger J.; Larson, David A.; Ruzzi, Peter L.

    1992-01-01

    An impact assisted segmented cutterhead device is provided for cutting various surfaces from coal to granite. The device comprises a plurality of cutting bit segments deployed in side by side relationship to form a continuous cutting face and a plurality of impactors individually associated with respective cutting bit segments. An impactor rod of each impactor connects that impactor to the corresponding cutting bit segment. A plurality of shock mounts dampening the vibration from the associated impactor. Mounting brackets are used in mounting the cutterhead to a base machine.

  12. Segmented pyroelector detector

    DOE Patents [OSTI]

    Stotlar, S.C.; McLellan, E.J.

    1981-01-21

    A pyroelectric detector is described which has increased voltage output and improved responsivity over equivalent size detectors. The device comprises a plurality of edge-type pyroelectric detectors which have a length which is much greater than the width of the segments between the edge-type electrodes. External circuitry connects the pyroelectric detector segments in parallel to provide a single output which maintains 50 ohm impedance characteristics.

  13. Segmented annular combustor

    DOE Patents [OSTI]

    Reider, Samuel B.

    1979-01-01

    An industrial gas turbine engine includes an inclined annular combustor made up of a plurality of support segments each including inner and outer walls of trapezoidally configured planar configuration extents and including side flanges thereon interconnected by means of air cooled connector bolt assemblies to form a continuous annular combustion chamber therebetween and wherein an air fuel mixing chamber is formed at one end of the support segments including means for directing and mixing fuel within a plenum and a perforated header plate for directing streams of air and fuel mixture into the combustion chamber; each of the outer and inner walls of each of the support segments having a ribbed lattice with tracks slidably supporting porous laminated replaceable panels and including pores therein for distributing combustion air into the combustion chamber while cooling the inner surface of each of the panels by transpiration cooling thereof.

  14. Segmented rail linear induction motor

    DOE Patents [OSTI]

    Cowan, M. Jr.; Marder, B.M.

    1996-09-03

    A segmented rail linear induction motor has a segmented rail consisting of a plurality of nonferrous electrically conductive segments aligned along a guideway. The motor further includes a carriage including at least one pair of opposed coils fastened to the carriage for moving the carriage. A power source applies an electric current to the coils to induce currents in the conductive surfaces to repel the coils from adjacent edges of the conductive surfaces. 6 figs.

  15. Segmented rail linear induction motor

    DOE Patents [OSTI]

    Cowan, Jr., Maynard; Marder, Barry M.

    1996-01-01

    A segmented rail linear induction motor has a segmented rail consisting of a plurality of nonferrous electrically conductive segments aligned along a guideway. The motor further includes a carriage including at least one pair of opposed coils fastened to the carriage for moving the carriage. A power source applies an electric current to the coils to induce currents in the conductive surfaces to repel the coils from adjacent edges of the conductive surfaces.

  16. Partially segmented deformable mirror

    DOE Patents [OSTI]

    Bliss, E.S.; Smith, J.R.; Salmon, J.T.; Monjes, J.A.

    1991-05-21

    A partially segmented deformable mirror is formed with a mirror plate having a smooth and continuous front surface and a plurality of actuators to its back surface. The back surface is divided into triangular areas which are mutually separated by grooves. The grooves are deep enough to make the plate deformable and the actuators for displacing the mirror plate in the direction normal to its surface are inserted in the grooves at the vertices of the triangular areas. Each actuator includes a transducer supported by a receptacle with outer shells having outer surfaces. The vertices have inner walls which are approximately perpendicular to the mirror surface and make planar contacts with the outer surfaces of the outer shells. The adhesive which is used on these contact surfaces tends to contract when it dries but the outer shells can bend and serve to minimize the tendency of the mirror to warp. 5 figures.

  17. Partially segmented deformable mirror

    DOE Patents [OSTI]

    Bliss, Erlan S.; Smith, James R.; Salmon, J. Thaddeus; Monjes, Julio A.

    1991-01-01

    A partially segmented deformable mirror is formed with a mirror plate having a smooth and continuous front surface and a plurality of actuators to its back surface. The back surface is divided into triangular areas which are mutually separated by grooves. The grooves are deep enough to make the plate deformable and the actuators for displacing the mirror plate in the direction normal to its surface are inserted in the grooves at the vertices of the triangular areas. Each actuator includes a transducer supported by a receptacle with outer shells having outer surfaces. The vertices have inner walls which are approximately perpendicular to the mirror surface and make planar contacts with the outer surfaces of the outer shells. The adhesive which is used on these contact surfaces tends to contract when it dries but the outer shells can bend and serve to minimize the tendency of the mirror to warp.

  18. Segmented heat exchanger

    DOE Patents [OSTI]

    Baldwin, Darryl Dean; Willi, Martin Leo; Fiveland, Scott Byron; Timmons, Kristine Ann

    2010-12-14

    A segmented heat exchanger system for transferring heat energy from an exhaust fluid to a working fluid. The heat exchanger system may include a first heat exchanger for receiving incoming working fluid and the exhaust fluid. The working fluid and exhaust fluid may travel through at least a portion of the first heat exchanger in a parallel flow configuration. In addition, the heat exchanger system may include a second heat exchanger for receiving working fluid from the first heat exchanger and exhaust fluid from a third heat exchanger. The working fluid and exhaust fluid may travel through at least a portion of the second heat exchanger in a counter flow configuration. Furthermore, the heat exchanger system may include a third heat exchanger for receiving working fluid from the second heat exchanger and exhaust fluid from the first heat exchanger. The working fluid and exhaust fluid may travel through at least a portion of the third heat exchanger in a parallel flow configuration.

  19. Optimal segmentation and packaging process

    DOE Patents [OSTI]

    Kostelnik, Kevin M.; Meservey, Richard H.; Landon, Mark D.

    1999-01-01

    A process for improving packaging efficiency uses three dimensional, computer simulated models with various optimization algorithms to determine the optimal segmentation process and packaging configurations based on constraints including container limitations. The present invention is applied to a process for decontaminating, decommissioning (D&D), and remediating a nuclear facility involving the segmentation and packaging of contaminated items in waste containers in order to minimize the number of cuts, maximize packaging density, and reduce worker radiation exposure. A three-dimensional, computer simulated, facility model of the contaminated items are created. The contaminated items are differentiated. The optimal location, orientation and sequence of the segmentation and packaging of the contaminated items is determined using the simulated model, the algorithms, and various constraints including container limitations. The cut locations and orientations are transposed to the simulated model. The contaminated items are actually segmented and packaged. The segmentation and packaging may be simulated beforehand. In addition, the contaminated items may be cataloged and recorded.

  20. Optimal segmentation and packaging process

    DOE Patents [OSTI]

    Kostelnik, K.M.; Meservey, R.H.; Landon, M.D.

    1999-08-10

    A process for improving packaging efficiency uses three dimensional, computer simulated models with various optimization algorithms to determine the optimal segmentation process and packaging configurations based on constraints including container limitations. The present invention is applied to a process for decontaminating, decommissioning (D and D), and remediating a nuclear facility involving the segmentation and packaging of contaminated items in waste containers in order to minimize the number of cuts, maximize packaging density, and reduce worker radiation exposure. A three-dimensional, computer simulated, facility model of the contaminated items are created. The contaminated items are differentiated. The optimal location, orientation and sequence of the segmentation and packaging of the contaminated items is determined using the simulated model, the algorithms, and various constraints including container limitations. The cut locations and orientations are transposed to the simulated model. The contaminated items are actually segmented and packaged. The segmentation and packaging may be simulated beforehand. In addition, the contaminated items may be cataloged and recorded. 3 figs.

  1. Automated bone segmentation from dental CBCT images using patch-based sparse representation and convex optimization

    SciTech Connect (OSTI)

    Wang, Li; Gao, Yaozong; Shi, Feng; Liao, Shu; Li, Gang; Chen, Ken Chung; Shen, Steve G. F.; Yan, Jin; Lee, Philip K. M.; Chow, Ben; Liu, Nancy X.; Xia, James J.; Shen, Dinggang

    2014-04-15

    Purpose: Cone-beam computed tomography (CBCT) is an increasingly utilized imaging modality for the diagnosis and treatment planning of the patients with craniomaxillofacial (CMF) deformities. Accurate segmentation of CBCT image is an essential step to generate three-dimensional (3D) models for the diagnosis and treatment planning of the patients with CMF deformities. However, due to the poor image quality, including very low signal-to-noise ratio and the widespread image artifacts such as noise, beam hardening, and inhomogeneity, it is challenging to segment the CBCT images. In this paper, the authors present a new automatic segmentation method to address these problems. Methods: To segment CBCT images, the authors propose a new method for fully automated CBCT segmentation by using patch-based sparse representation to (1) segment bony structures from the soft tissues and (2) further separate the mandible from the maxilla. Specifically, a region-specific registration strategy is first proposed to warp all the atlases to the current testing subject and then a sparse-based label propagation strategy is employed to estimate a patient-specific atlas from all aligned atlases. Finally, the patient-specific atlas is integrated into amaximum a posteriori probability-based convex segmentation framework for accurate segmentation. Results: The proposed method has been evaluated on a dataset with 15 CBCT images. The effectiveness of the proposed region-specific registration strategy and patient-specific atlas has been validated by comparing with the traditional registration strategy and population-based atlas. The experimental results show that the proposed method achieves the best segmentation accuracy by comparison with other state-of-the-art segmentation methods. Conclusions: The authors have proposed a new CBCT segmentation method by using patch-based sparse representation and convex optimization, which can achieve considerably accurate segmentation results in CBCT

  2. Distinctive Appliances: Order (2015-CE-14019)

    Broader source: Energy.gov [DOE]

    DOE ordered Distinctive Appliances Distributing, Inc. to pay a $16,000 civil penalty after finding Distinctive Appliances had failed to certify that certain models of Fhiaba-brand refrigerator-freezers comply with the applicable energy conservation standards.

  3. Distinctive Appliances: Order (2014-CE-23020)

    Broader source: Energy.gov [DOE]

    DOE ordered Distinctive Appliances Distributing, Inc. to pay a $8,000 civil penalty after finding Distinctive Appliances had failed to certify that certain models of cooking products comply with the applicable energy conservation standards.

  4. @ work' video segment features Robotic Software Engineer

    SciTech Connect (OSTI)

    Idaho National Laboratory

    2008-03-27

    @ work highlights Idaho National Laboratory employees and the jobs they perform.This segment features Robotic Software Engineer Miles Walton.

  5. Financing Program Market Segments | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Market Segments Financing Program Market Segments Financing programs are not one-size-fits-all-different financial products will work better for different market segments. Markets to consider include: Public Sector Residential Commercial and Industrial Select a financing structure in the table for more information. Financing Structures Market Segment Public Sector Residential Commercial Small Business Bonds X X X Clean Renewable Energy Bonds X Energy Efficient Mortgages X Energy Savings

  6. @ work' video segment features Robotic Software Engineer

    ScienceCinema (OSTI)

    Idaho National Laboratory

    2010-01-08

    @ work highlights Idaho National Laboratory employees and the jobs they perform.This segment features Robotic Software Engineer Miles Walton.

  7. Segmented ceramic liner for induction furnaces

    DOE Patents [OSTI]

    Gorin, A.H.; Holcombe, C.E.

    1994-07-26

    A non-fibrous ceramic liner for induction furnaces is provided by vertically stackable ring-shaped liner segments made of ceramic material in a light-weight cellular form. The liner segments can each be fabricated as a single unit or from a plurality of arcuate segments joined together by an interlocking mechanism. Also, the liner segments can be formed of a single ceramic material or can be constructed of multiple concentric layers with the layers being of different ceramic materials and/or cellular forms. Thermomechanically damaged liner segments are selectively replaceable in the furnace. 5 figs.

  8. Segmented ceramic liner for induction furnaces

    DOE Patents [OSTI]

    Gorin, Andrew H.; Holcombe, Cressie E.

    1994-01-01

    A non-fibrous ceramic liner for induction furnaces is provided by vertically stackable ring-shaped liner segments made of ceramic material in a light-weight cellular form. The liner segments can each be fabricated as a single unit or from a plurality of arcuate segments joined together by an interlocking mechanism. Also, the liner segments can be formed of a single ceramic material or can be constructed of multiple concentric layers with the layers being of different ceramic materials and/or cellular forms. Thermomechanically damaged liner segments are selectively replaceable in the furnace.

  9. Special Population Planner for Emergency Management

    Energy Science and Technology Software Center (OSTI)

    2003-04-17

    The SPP is a tool for use by emergency management agencies in creating plans for possible events requiring their attention. It incorporates extensive data including those on special needs populations so that this segment of the population will be considered in general plans.

  10. Distinctive Appliances: Proposed Penalty (2014-CE-23020)

    Broader source: Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that Distinctive Appliances Distributing Inc. failed to certify cooking products as compliant with the applicable energy conservation standards.

  11. Cooling system for three hook ring segment

    DOE Patents [OSTI]

    Campbell, Christian X.; Eng, Darryl; Lee, Ching-Pang; Patat, Harry

    2014-08-26

    A triple hook ring segment including forward, midsection and aft mounting hooks for engagement with respective hangers formed on a ring segment carrier for supporting a ring segment panel, and defining a forward high pressure chamber and an aft low pressure chamber on opposing sides of the midsection mounting hook. An isolation plate is provided on the aft side of the midsection mounting hook to form an isolation chamber between the aft low pressure chamber and the ring segment panel. High pressure air is supplied to the forward chamber and flows to the isolation chamber through crossover passages in the midsection hook. The isolation chamber provides convection cooling air to an aft portion of the ring segment panel and enables a reduction of air pressure in the aft low pressure chamber to reduce leakage flow of cooling air from the ring segment.

  12. Hierarchical image segmentation for learning object priors

    SciTech Connect (OSTI)

    Prasad, Lakshman; Yang, Xingwei; Latecki, Longin J; Li, Nan

    2010-11-10

    The proposed segmentation approach naturally combines experience based and image based information. The experience based information is obtained by training a classifier for each object class. For a given test image, the result of each classifier is represented as a probability map. The final segmentation is obtained with a hierarchial image segmentation algorithm that considers both the probability maps and the image features such as color and edge strength. We also utilize image region hierarchy to obtain not only local but also semi-global features as input to the classifiers. Moreover, to get robust probability maps, we take into account the region context information by averaging the probability maps over different levels of the hierarchical segmentation algorithm. The obtained segmentation results are superior to the state-of-the-art supervised image segmentation algorithms.

  13. Fluidized bed boiler having a segmented grate

    DOE Patents [OSTI]

    Waryasz, Richard E.

    1984-01-01

    A fluidized bed furnace (10) is provided having a perforate grate (9) within a housing which supports a bed of particulate material including some combustibles. The grate is divided into a plurality of segments (E2-E6, SH1-SH5, RH1-RH5), with the airflow to each segment being independently controlled. Some of the segments have evaporating surface imbedded in the particulate material above them, while other segments are below superheater surface or reheater surface. Some of the segments (E1, E7) have no surface above them, and there are ignitor combustors (32, 34) directed to fire into the segments, for fast startup of the furnace without causing damage to any heating surface.

  14. Market Segmentation and Energy Efficiency Program Design

    Broader source: Energy.gov [DOE]

    Describe the existing state of market segmentation among California’s electric utilities, with an emphasis on the investor-owned utilities. Author: Steve J. Moss

  15. Segmented amplifier configurations for laser amplifier

    DOE Patents [OSTI]

    Hagen, Wilhelm F.

    1979-01-01

    An amplifier system for high power lasers, the system comprising a compact array of segments which (1) preserves high, large signal gain with improved pumping efficiency and (2) allows the total amplifier length to be shortened by as much as one order of magnitude. The system uses a three dimensional array of segments, with the plane of each segment being oriented at substantially the amplifier medium Brewster angle relative to the incident laser beam and with one or more linear arrays of flashlamps positioned between adjacent rows of amplifier segments, with the plane of the linear array of flashlamps being substantially parallel to the beam propagation direction.

  16. Segmented Nanowires Displaying Locally Controllable Properties...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vapor-liquid-solid growth of nanowires is tailored to achieve complex one-dimensional material geometries using phase diagrams determined for nanoscale materials. Segmented...

  17. Improving image segmentation by learning region affinities

    SciTech Connect (OSTI)

    Prasad, Lakshman; Yang, Xingwei; Latecki, Longin J

    2010-11-03

    We utilize the context information of other regions in hierarchical image segmentation to learn new regions affinities. It is well known that a single choice of quantization of an image space is highly unlikely to be a common optimal quantization level for all categories. Each level of quantization has its own benefits. Therefore, we utilize the hierarchical information among different quantizations as well as spatial proximity of their regions. The proposed affinity learning takes into account higher order relations among image regions, both local and long range relations, making it robust to instabilities and errors of the original, pairwise region affinities. Once the learnt affinities are obtained, we use a standard image segmentation algorithm to get the final segmentation. Moreover, the learnt affinities can be naturally unutilized in interactive segmentation. Experimental results on Berkeley Segmentation Dataset and MSRC Object Recognition Dataset are comparable and in some aspects better than the state-of-art methods.

  18. Distinctive Appliances: Proposed Penalty (2015-CE-14019)

    Broader source: Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that Distinctive Appliances Distributing, Inc. failed to certify various Fhiaba-brand refrigerator-freezers as compliant with the applicable energy conservation standards.

  19. Method of manufacturing a large-area segmented photovoltaic module

    DOE Patents [OSTI]

    Lenox, Carl

    2013-11-05

    One embodiment of the invention relates to a segmented photovoltaic (PV) module which is manufactured from laminate segments. The segmented PV module includes rectangular-shaped laminate segments formed from rectangular-shaped PV laminates and further includes non-rectangular-shaped laminate segments formed from rectangular-shaped and approximately-triangular-shaped PV laminates. The laminate segments are mechanically joined and electrically interconnected to form the segmented module. Another embodiment relates to a method of manufacturing a large-area segmented photovoltaic module from laminate segments of various shapes. Other embodiments relate to processes for providing a photovoltaic array for installation at a site. Other embodiments and features are also disclosed.

  20. Vane segment support and alignment device

    DOE Patents [OSTI]

    McLaurin, L.D.; Sizemore, J.D.

    1999-07-13

    A support and alignment assembly for supporting and aligning a vane segment is provided. The support and alignment assembly comprises a torque plate which defines an opening for receiving an eccentric pin and a locking end member for receiving a lock socket member. An eccentric pin adjustably supported by the torque plate opening for supporting and aligning a vane segment is provided. A lock socket member adapted to securely receive the eccentric pin and rotated therewith, and adjustably engage the torque plate locking end is provided. The lock socket member receives the eccentric pin, such that when the eccentric pin is adjusted to align the vane segment, the lock socket member engages the torque plate locking end to secure the vane segment in the desired position. 5 figs.

  1. Vane segment support and alignment device

    DOE Patents [OSTI]

    McLaurin, Leroy Dixon; Sizemore, John Derek

    1999-01-01

    A support and alignment assembly for supporting and aligning a vane segment is provided. The support and alignment assembly comprises a torque plate which defines an opening for receiving an eccentric pin and a locking end member for receiving a lock socket member. An eccentric pin adjustably supported by the torque plate opening for supporting and aligning a vane segment is provided. A lock socket member adapted to securely receive the eccentric pin and rotated therewith, and adjustably engage the torque plate locking end is provided. The lock socket member receives the eccentric pin, such that when the eccentric pin is adjusted to align the vane segment, the lock socket member engages the torque plate locking end to secure the vane segment in the desired position.

  2. Household Energy Consumption Segmentation Using Hourly Data

    SciTech Connect (OSTI)

    Kwac, J; Flora, J; Rajagopal, R

    2014-01-01

    The increasing US deployment of residential advanced metering infrastructure (AMI) has made hourly energy consumption data widely available. Using CA smart meter data, we investigate a household electricity segmentation methodology that uses an encoding system with a pre-processed load shape dictionary. Structured approaches using features derived from the encoded data drive five sample program and policy relevant energy lifestyle segmentation strategies. We also ensure that the methodologies developed scale to large data sets.

  3. Newport News in Review, ch. 47, segment includes TEDF groundbreaking...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    https:www.jlab.orgnewsarticlesnewport-news-review-ch-47-segment-includes-tedf-groundbreaking-event Newport News in Review, ch. 47, segment includes TEDF groundbreaking event...

  4. Audience Segmentation and Analysis Strategies for Targeted Marketing...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Audience Segmentation and Analysis Strategies for Targeted Marketing (301) Audience Segmentation and Analysis Strategies for Targeted Marketing (301) September 24, 2015 12:30PM to...

  5. Decoupling of Ionic Transport from Segmental Relaxation in Polymer...

    Office of Scientific and Technical Information (OSTI)

    Publisher's Accepted Manuscript: Decoupling of Ionic Transport from Segmental Relaxation in Polymer Electrolytes Prev Next Title: Decoupling of Ionic Transport from Segmental ...

  6. Audience Segmentation and Analysis Strategies for Targeted Marketing...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Audience Segmentation and Analysis Strategies for Targeted Marketing (301) Audience Segmentation and Analysis Strategies for Targeted Marketing (301) Better Buildings Residential ...

  7. Nuclear propulsion apparatus with alternate reactor segments

    DOE Patents [OSTI]

    Szekely, Thomas

    1979-04-03

    1. Nuclear propulsion apparatus comprising: A. means for compressing incoming air; B. nuclear fission reactor means for heating said air; C. means for expanding a portion of the heated air to drive said compressing means; D. said nuclear fission reactor means being divided into a plurality of radially extending segments; E. means for directing a portion of the compressed air for heating through alternate segments of said reactor means and another portion of the compressed air for heating through the remaining segments of said reactor means; and F. means for further expanding the heated air from said drive means and the remaining heated air from said reactor means through nozzle means to effect reactive thrust on said apparatus.

  8. Distinctive properties of tabular solar chemical reactors

    SciTech Connect (OSTI)

    Meirovitch, E. )

    1991-01-01

    Concentrated sunlight that can be stored in the chemical bond by activating an endothermic reaction. This novel concept has been implemented recently with solar power captured in a central receiver equipped with chemical reactors. The related theory, presented in this report, singles out this interactive radiative-chemical system as distinctively stable thermodynamically, resilient to perturbations, internally regulatory and self-corrective. None of the thermochemical devices conceived so far bear all these attributes.

  9. Segmented nanowires displaying locally controllable properties

    DOE Patents [OSTI]

    Sutter, Eli Anguelova; Sutter, Peter Werner

    2013-03-05

    Vapor-liquid-solid growth of nanowires is tailored to achieve complex one-dimensional material geometries using phase diagrams determined for nanoscale materials. Segmented one-dimensional nanowires having constant composition display locally variable electronic band structures that are determined by the diameter of the nanowires. The unique electrical and optical properties of the segmented nanowires are exploited to form electronic and optoelectronic devices. Using gold-germanium as a model system, in situ transmission electron microscopy establishes, for nanometer-sized Au--Ge alloy drops at the tips of Ge nanowires (NWs), the parts of the phase diagram that determine their temperature-dependent equilibrium composition. The nanoscale phase diagram is then used to determine the exchange of material between the NW and the drop. The phase diagram for the nanoscale drop deviates significantly from that of the bulk alloy.

  10. Segmented foil SEM grids at Fermilab

    SciTech Connect (OSTI)

    Kopp, S.; Indurthy, D.; Pavlovic, Z.; Proga, M.; Zwaska, R.; Baller, B.; Childress, S.; Ford, R.; Harris, D.; Kendziora, C.; Moore, Craig D.; Tassotto, G.; /Fermilab

    2005-05-01

    We present recent beam data from a new design of a profile monitor for proton beams at Fermilab. The monitors, consisting of grids of segmented Ti foils 5{micro}m thick, are secondary-electron emission monitors (SEM's) We review data on the device's precision on beam centroid position, beam width, and on beam loss associated with the SEM material placed in the beam.

  11. Smart Meter Driven Segmentation: What Your Consumption Says About You

    SciTech Connect (OSTI)

    Albert, A; Rajagopal, R

    2013-11-01

    With the rollout of smart metering infrastructure at scale, demand-response (DR) programs may now be tailored based on users' consumption patterns as mined from sensed data. For issuing DR events it is key to understand the inter-temporal consumption dynamics as to appropriately segment the user population. We propose to infer occupancy states from consumption time series data using a hidden Markov model framework. Occupancy is characterized in this model by 1) magnitude, 2) duration, and 3) variability. We show that users may be grouped according to their consumption patterns into groups that exhibit qualitatively different dynamics that may be exploited for program enrollment purposes. We investigate empirically the information that residential energy consumers' temporal energy demand patterns characterized by these three dimensions may convey about their demographic, household, and appliance stock characteristics. Our analysis shows that temporal patterns in the user's consumption data can predict with good accuracy certain user characteristics. We use this framework to argue that there is a large degree of individual predictability in user consumption at a population level.

  12. Market Segmentation and Energy Efficiency Program Design (2008...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    More Documents & Publications Market Segmentation and Energy Efficiency Program Design Behavioral Assumptions Underlying California Residential Sector Energy Efficiency Programs ...

  13. Audience Segmentation and Analysis Strategies for Targeted Marketing (301)

    Broader source: Energy.gov [DOE]

    Better Buildings Residential Network Peer Exchange Call Series: Audience Segmentation and Analysis Strategies for Targeted Marketing (301).

  14. Apparatus For Laminating Segmented Core For Electric Machine

    DOE Patents [OSTI]

    Lawrence, Robert Anthony; Stabel, Gerald R

    2003-06-17

    A segmented core for an electric machine includes segments stamped from coated electric steel. The segments each have a first end, a second end, and winding openings. A predetermined number of segments are placed end-to-end to form layers. The layers are stacked such that each of the layers is staggered from adjacent layers by a predetermined rotation angle. The winding openings of each of the layers are in vertical alignment with the winding openings of the adjacent layers. The stack of layers is secured to form the segmented core.

  15. Segmented electrode hall thruster with reduced plume

    DOE Patents [OSTI]

    Fisch, Nathaniel J.; Raitses, Yevgeny

    2004-08-17

    An apparatus and method for thrusting plasma, utilizing a Hall thruster with segmented electrodes along the channel, which make the acceleration region as localized as possible. Also disclosed are methods of arranging the electrodes so as to minimize erosion and arcing. Also disclosed are methods of arranging the electrodes so as to produce a substantial reduction in plume divergence. The use of electrodes made of emissive material will reduce the radial potential drop within the channel, further decreasing the plume divergence. Also disclosed is a method of arranging and powering these electrodes so as to provide variable mode operation.

  16. Distinct optical properties of relativistically degenerate matter

    SciTech Connect (OSTI)

    Akbari-Moghanjoughi, M.

    2014-06-15

    In this paper, we use the collisional quantum magnetohydrodynamic (CQMHD) model to derive the transverse dielectric function of a relativistically degenerate electron fluid and investigate various optical parameters, such as the complex refractive index, the reflection and absorption coefficients, the skin-depth and optical conductivity. In this model we take into accounts effects of many parameters such as the atomic-number of the constituent ions, the electron exchange, electron diffraction effect and the electron-ion collisions. Study of the optical parameters in the solid-density, the warm-dense-matter, the big-planetary core, and the compact star number-density regimes reveals that there are distinct differences between optical characteristics of the latter and the former cases due to the fundamental effects of the relativistic degeneracy and other quantum mechanisms. It is found that in the relativistic degeneracy plasma regime, such as found in white-dwarfs and neutron star crusts, matter possess a much sharper and well-defined step-like reflection edge beyond the x-ray electromagnetic spectrum, including some part of gamma-ray frequencies. It is also remarked that the magnetic field intensity only significantly affects the plasma reflectivity in the lower number-density regime, rather than the high density limit. Current investigation confirms the profound effect of relativistic degeneracy on optical characteristics of matter and can provide an important plasma diagnostic tool for studying the physical processes within the wide scope of quantum plasma regimes be it the solid-density, inertial-confined, or astrophysical compact stars.

  17. Segmented lasing tube for high temperature laser assembly

    DOE Patents [OSTI]

    Sawicki, Richard H.; Alger, Terry W.; Finucane, Raymond G.; Hall, Jerome P.

    1996-01-01

    A high temperature laser assembly capable of withstanding operating temperatures in excess of 1500.degree. C. is described comprising a segmented cylindrical ceramic lasing tube having a plurality of cylindrical ceramic lasing tube segments of the same inner and outer diameters non-rigidly joined together in axial alignment; insulation of uniform thickness surround the walls of the ceramic lasing tube; a ceramic casing, preferably of quartz, surrounding the insulation; and a fluid cooled metal jacket surrounds the ceramic casing. In a preferred embodiment, the inner surface of each of the ceramic lasing tube segments are provided with a pair of oppositely spaced grooves in the wall thereof parallel to the center axis of the segmented cylindrical ceramic lasing tube, and both of the grooves and the center axis of the segmented cylindrical ceramic lasing tube lie in a common plane, with the grooves in each ceramic lasing tube segment in circumferential alignment with the grooves in the adjoining ceramic lasing tube segments; and one or more ceramic plates, all lying in a common plane to one another and with the central axis of the segmented ceramic lasing tube, are received in the grooves to provide additional wall area in the segmented ceramic lasing tube for collision and return to ground state of metastable metal atoms within the segmented ceramic lasing tube.

  18. Deformable segmentation of 3D MR prostate images via distributed discriminative dictionary and ensemble learning

    SciTech Connect (OSTI)

    Guo, Yanrong; Shao, Yeqin; Gao, Yaozong; Price, True; Oto, Aytekin; Shen, Dinggang

    2014-07-15

    Purpose: Automatic prostate segmentation from MR images is an important task in various clinical applications such as prostate cancer staging and MR-guided radiotherapy planning. However, the large appearance and shape variations of the prostate in MR images make the segmentation problem difficult to solve. Traditional Active Shape/Appearance Model (ASM/AAM) has limited accuracy on this problem, since its basic assumption, i.e., both shape and appearance of the targeted organ follow Gaussian distributions, is invalid in prostate MR images. To this end, the authors propose a sparse dictionary learning method to model the image appearance in a nonparametric fashion and further integrate the appearance model into a deformable segmentation framework for prostate MR segmentation. Methods: To drive the deformable model for prostate segmentation, the authors propose nonparametric appearance and shape models. The nonparametric appearance model is based on a novel dictionary learning method, namely distributed discriminative dictionary (DDD) learning, which is able to capture fine distinctions in image appearance. To increase the differential power of traditional dictionary-based classification methods, the authors' DDD learning approach takes three strategies. First, two dictionaries for prostate and nonprostate tissues are built, respectively, using the discriminative features obtained from minimum redundancy maximum relevance feature selection. Second, linear discriminant analysis is employed as a linear classifier to boost the optimal separation between prostate and nonprostate tissues, based on the representation residuals from sparse representation. Third, to enhance the robustness of the authors' classification method, multiple local dictionaries are learned for local regions along the prostate boundary (each with small appearance variations), instead of learning one global classifier for the entire prostate. These discriminative dictionaries are located on different

  19. 3D liver segmentation using multiple region appearances and graph cuts

    SciTech Connect (OSTI)

    Peng, Jialin Zhang, Hongbo; Hu, Peijun; Lu, Fang; Kong, Dexing; Peng, Zhiyi

    2015-12-15

    Purpose: Efficient and accurate 3D liver segmentations from contrast-enhanced computed tomography (CT) images play an important role in therapeutic strategies for hepatic diseases. However, inhomogeneous appearances, ambiguous boundaries, and large variance in shape often make it a challenging task. The existence of liver abnormalities poses further difficulty. Despite the significant intensity difference, liver tumors should be segmented as part of the liver. This study aims to address these challenges, especially when the target livers contain subregions with distinct appearances. Methods: The authors propose a novel multiregion-appearance based approach with graph cuts to delineate the liver surface. For livers with multiple subregions, a geodesic distance based appearance selection scheme is introduced to utilize proper appearance constraint for each subregion. A special case of the proposed method, which uses only one appearance constraint to segment the liver, is also presented. The segmentation process is modeled with energy functions incorporating both boundary and region information. Rather than a simple fixed combination, an adaptive balancing weight is introduced and learned from training sets. The proposed method only calls initialization inside the liver surface. No additional constraints from user interaction are utilized. Results: The proposed method was validated on 50 3D CT images from three datasets, i.e., Medical Image Computing and Computer Assisted Intervention (MICCAI) training and testing set, and local dataset. On MICCAI testing set, the proposed method achieved a total score of 83.4 ± 3.1, outperforming nonexpert manual segmentation (average score of 75.0). When applying their method to MICCAI training set and local dataset, it yielded a mean Dice similarity coefficient (DSC) of 97.7% ± 0.5% and 97.5% ± 0.4%, respectively. These results demonstrated the accuracy of the method when applied to different computed tomography (CT) datasets

  20. Identifying Turbulent Structures through Topological Segmentation

    SciTech Connect (OSTI)

    Bremer, Peer-Timo; Gruber, Andrea; Bennett, Janine C.; Gyulassy, Attila; Kolla, Hemanth; Chen, Jacqueline H.; Grout, Ray W.

    2016-01-01

    A new method of extracting vortical structures from a turbulent flow is proposed whereby topological segmentation of an indicator function scalar field is used to identify the regions of influence of the individual vortices. This addresses a long-standing challenge in vector field topological analysis: indicator functions commonly used produce a scalar field based on the local velocity vector field; reconstructing regions of influence for a particular structure requires selecting a threshold to define vortex extent. In practice, the same threshold is rarely meaningful throughout a given flow. By also considering the topology of the indicator field function, the characteristics of vortex strength and extent can be separated and the ambiguity in the choice of the threshold reduced. The proposed approach is able to identify several types of vortices observed in a jet in cross-flow configuration simultaneously where no single threshold value for a selection of common indicator functions appears able to identify all of these vortex types.

  1. Cutting assembly including expanding wall segments of auger

    DOE Patents [OSTI]

    Treuhaft, Martin B.; Oser, Michael S.

    1983-01-01

    A mining auger comprises a cutting head carried at one end of a tubular shaft and a plurality of wall segments which in a first position thereof are disposed side by side around said shaft and in a second position thereof are disposed oblique to said shaft. A vane projects outwardly from each wall segment. When the wall segments are in their first position, the vanes together form a substantially continuous helical wall. A cutter is mounted on the peripheral edge of each of the vanes. When the wall segments are in their second position, the cutters on the vanes are disposed radially outward from the perimeter of the cutting head.

  2. A Dielectric Relaxometry Study of Segmental Dynamics in PDMS...

    Office of Scientific and Technical Information (OSTI)

    A Dielectric Relaxometry Study of Segmental Dynamics in PDMSBoron Composite and Hybrid Elastomers Citation Details In-Document Search Title: A Dielectric Relaxometry Study of...

  3. A Dielectric Relaxometry Study of Segmental Dynamics in PDMS...

    Office of Scientific and Technical Information (OSTI)

    in PDMSBoron Composite and Hybrid Elastomers Citation Details In-Document Search Title: A Dielectric Relaxometry Study of Segmental Dynamics in PDMSBoron Composite and ...

  4. Role of Polymer Segment-Particle Surface Interactions in Controlling...

    Office of Scientific and Technical Information (OSTI)

    Role of Polymer Segment-Particle Surface Interactions in Controlling Nanoparticle Dispersions in Concentrated Polymer Solutions Citation Details In-Document Search Title: Role of ...

  5. Market Segmentation and Energy Efficiency Program Design (2008 CIEE Report)

    Broader source: Energy.gov [DOE]

    This paper describes the existing state of market segmentation among California’s electric utilities, with an emphasis on the investor-owned utilities (IOUs).

  6. Active Fault Segments As Potential Earthquake Sources- Inferences...

    Open Energy Info (EERE)

    Segments As Potential Earthquake Sources- Inferences From Integrated Geophysical Mapping Of The Magadi Fault System, Southern Kenya Rift Jump to: navigation, search OpenEI...

  7. Review methods for image segmentation from computed tomography images

    SciTech Connect (OSTI)

    Mamat, Nurwahidah; Rahman, Wan Eny Zarina Wan Abdul; Soh, Shaharuddin Cik; Mahmud, Rozi

    2014-12-04

    Image segmentation is a challenging process in order to get the accuracy of segmentation, automation and robustness especially in medical images. There exist many segmentation methods that can be implemented to medical images but not all methods are suitable. For the medical purposes, the aims of image segmentation are to study the anatomical structure, identify the region of interest, measure tissue volume to measure growth of tumor and help in treatment planning prior to radiation therapy. In this paper, we present a review method for segmentation purposes using Computed Tomography (CT) images. CT images has their own characteristics that affect the ability to visualize anatomic structures and pathologic features such as blurring of the image and visual noise. The details about the methods, the goodness and the problem incurred in the methods will be defined and explained. It is necessary to know the suitable segmentation method in order to get accurate segmentation. This paper can be a guide to researcher to choose the suitable segmentation method especially in segmenting the images from CT scan.

  8. Molecular Basis for the Recognition of Structurally Distinct...

    Office of Scientific and Technical Information (OSTI)

    Distinct Autoinducer Mimics by the Pseudomonas aeruginosa LasR Quorum-Sensing Signaling ... of infection and host immune resistance, significant efforts have been ...

  9. ORNL FISH Telomere Segmentation GUI and Instruction Manual

    Energy Science and Technology Software Center (OSTI)

    2002-12-01

    The ORNL FISH Telomere Segmentation GUI takes images of cellular chromosomes and telomeres obtained through Fluorescent in-situ Hybridization and automatically labels the pixels that belong to the chromosomes and telomeres, which are cellular structures of interest to cancer researchers. The process of labeling the pixels is called segmentation. The resulting segmentation can be edited through the use of an extensive graphical user-interface or GUI, saved, and exported to a data file suitable for use withmore » data analysis programs such as Microsoft Excel.« less

  10. Segmented instrumentation tube including a locking sleeve for interlocking the segments of the instrumentation tube

    DOE Patents [OSTI]

    Obermeyer, Franklin D. (Pensacola, FL)

    1993-01-01

    Segmented instrumentation tube including a locking sleeve for interlocking the segments of the instrumentation tube, so that the threaded ends of the instrumentation tube do not unthread when subjected to vibration, such an instrumentation tube being suitable for use in a nuclear reactor pressure vessel. The instrumentation tube has a first member having a threaded end portion that has a plurality of first holes circumferentially around the outside surface thereof. The instrumentation tube also has a second member having a threaded end portion that has a plurality of second holes circumferentially around the outside surface thereof. The threads of the second member are caused to threadably engage the threads of the first member for defining a threaded joint therebetween. A sleeve having an inside surface surrounds the end portion of the first member and the end portion of the second member and thus surrounds the threaded joint. The sleeve includes a plurality of first projections and second projections that outwardly extend from the inside surface to engage the first holes and the second holes, respectively. The outside surface of the sleeve is crimped or swaged at the locations of the first projections and second projections such that the first projections and the second projections engage their respective holes. In this manner, independent rotation of the first member with respect to the second member is prevented, so that the instrumentation tube will not unthread at its threaded joint.

  11. Segmented instrumentation tube including a locking sleeve for interlocking the segments of the instrumentation tube

    DOE Patents [OSTI]

    Obermeyer, F.D.

    1993-11-16

    Segmented instrumentation tube including a locking sleeve for interlocking the segments of the instrumentation tube, so that the threaded ends of the instrumentation tube do not unthread when subjected to vibration, such an instrumentation tube being suitable for use in a nuclear reactor pressure vessel. The instrumentation tube has a first member having a threaded end portion that has a plurality of first holes circumferentially around the outside surface thereof. The instrumentation tube also has a second member having a threaded end portion that has a plurality of second holes circumferentially around the outside surface thereof. The threads of the second member are caused to threadably engage the threads of the first member for defining a threaded joint there between. A sleeve having an inside surface surrounds the end portion of the first member and the end portion of the second member and thus surrounds the threaded joint. The sleeve includes a plurality of first projections and second projections that outwardly extend from the inside surface to engage the first holes and the second holes, respectively. The outside surface of the sleeve is crimped or swaged at the locations of the first projections and second projections such that the first projections and the second projections engage their respective holes. In this manner, independent rotation of the first member with respect to the second member is prevented, so that the instrumentation tube will not unthread at its threaded joint. 10 figures.

  12. Curved track segment finding using Tiny Triplet Finder (TTF)

    SciTech Connect (OSTI)

    Wu, Jin-Yuan; Wang, M.; Gottschalk, E.; Shi, Z.; /Fermilab

    2006-11-01

    We describe the applications of a track segment recognition scheme called the Tiny Triplet Finder (TTF) that involves the grouping of three hits satisfying a constraint forming of a track segment. The TTF was originally developed solving straight track segment finding problem, however, it is also suitable in many curved track segment finding problems. The examples discussed in this document are among popular detector layouts in high-energy/nuclear physics experiments. Although it is not practical to find a universal recipe for arbitrary detector layouts, the method of the TTF application is illustrated via the discussion of the examples. Generally speaking, whenever the data item to be found in a pattern recognition problem contains two free parameters, and if the constraint connecting the measurements and the two free parameters has an approximate shift invariant property, the Tiny Triplet Finder can be used.

  13. EIA - Natural Gas Pipeline Network - Interstate Pipelines Segment

    U.S. Energy Information Administration (EIA) Indexed Site

    Interstate Natural Gas Pipeline Segment About U.S. Natural Gas Pipelines - Transporting Natural Gas based on data through 2007/2008 with selected updates Interstate Natural Gas Pipeline Segment Two-thirds of the lower 48 States are almost totally dependent upon the interstate pipeline system for their supplies of natural gas. On the interstate pipeline grid, the long-distance, wide-diameter (20-42 inch), high capacity trunklines carry most of the natural gas that is transported throughout the

  14. Semiautomatic segmentation of liver metastases on volumetric CT images

    SciTech Connect (OSTI)

    Yan, Jiayong; Schwartz, Lawrence H.; Zhao, Binsheng

    2015-11-15

    Purpose: Accurate segmentation and quantification of liver metastases on CT images are critical to surgery/radiation treatment planning and therapy response assessment. To date, there are no reliable methods to perform such segmentation automatically. In this work, the authors present a method for semiautomatic delineation of liver metastases on contrast-enhanced volumetric CT images. Methods: The first step is to manually place a seed region-of-interest (ROI) in the lesion on an image. This ROI will (1) serve as an internal marker and (2) assist in automatically identifying an external marker. With these two markers, lesion contour on the image can be accurately delineated using traditional watershed transformation. Density information will then be extracted from the segmented 2D lesion and help determine the 3D connected object that is a candidate of the lesion volume. The authors have developed a robust strategy to automatically determine internal and external markers for marker-controlled watershed segmentation. By manually placing a seed region-of-interest in the lesion to be delineated on a reference image, the method can automatically determine dual threshold values to approximately separate the lesion from its surrounding structures and refine the thresholds from the segmented lesion for the accurate segmentation of the lesion volume. This method was applied to 69 liver metastases (1.1–10.3 cm in diameter) from a total of 15 patients. An independent radiologist manually delineated all lesions and the resultant lesion volumes served as the “gold standard” for validation of the method’s accuracy. Results: The algorithm received a median overlap, overestimation ratio, and underestimation ratio of 82.3%, 6.0%, and 11.5%, respectively, and a median average boundary distance of 1.2 mm. Conclusions: Preliminary results have shown that volumes of liver metastases on contrast-enhanced CT images can be accurately estimated by a semiautomatic segmentation

  15. Image segmentation by hierarchial agglomeration of polygons using ecological statistics

    DOE Patents [OSTI]

    Prasad, Lakshman; Swaminarayan, Sriram

    2013-04-23

    A method for rapid hierarchical image segmentation based on perceptually driven contour completion and scene statistics is disclosed. The method begins with an initial fine-scale segmentation of an image, such as obtained by perceptual completion of partial contours into polygonal regions using region-contour correspondences established by Delaunay triangulation of edge pixels as implemented in VISTA. The resulting polygons are analyzed with respect to their size and color/intensity distributions and the structural properties of their boundaries. Statistical estimates of granularity of size, similarity of color, texture, and saliency of intervening boundaries are computed and formulated into logical (Boolean) predicates. The combined satisfiability of these Boolean predicates by a pair of adjacent polygons at a given segmentation level qualifies them for merging into a larger polygon representing a coarser, larger-scale feature of the pixel image and collectively obtains the next level of polygonal segments in a hierarchy of fine-to-coarse segmentations. The iterative application of this process precipitates textured regions as polygons with highly convolved boundaries and helps distinguish them from objects which typically have more regular boundaries. The method yields a multiscale decomposition of an image into constituent features that enjoy a hierarchical relationship with features at finer and coarser scales. This provides a traversable graph structure from which feature content and context in terms of other features can be derived, aiding in automated image understanding tasks. The method disclosed is highly efficient and can be used to decompose and analyze large images.

  16. Energy implications of an aging population

    SciTech Connect (OSTI)

    Not Available

    1980-08-01

    This study provides various demographic, medical, and economic information relative to energy usage on a segment of the population, the elderly, which is growing in absolute numbers and relative population percentage. This growth is expected to continue well into the twenty-first century. The US aging population numbered 3.1 million in 1900, and by 1977 it had climbed to 23.5 million. It can be stated with reasonable certainty that this figure will rise to 31 million in the year 2000 and 43 million in the year 2020. These figures, corresponding to more than 10% of our population, are by no means insignificant. As our fossil-fuel reserves are being depleted and the cost of energy mounts, it becomes apparent that the elderly will become increasingly vulnerable to the energy crisis, primarily beause of their physical tendency to infirmity, their economic and social situation, and their susceptibility to psychological depression. This white paper concentrates on those aspects of aging and the nation's energy problem which are not usually related in our everyday consideration of these as separable problems. It seeks to identify the peculiar energy problems of the aged and to consider alternatives in the solution of these problems in light of modern technology.

  17. Side wall cooling for nozzle segments for a gas turbine

    DOE Patents [OSTI]

    Burdgick, Steven Sebastian (Schenectady, NY)

    2002-01-01

    A nozzle vane segment includes outer and inner band portions with a vane extending therebetween and defining first and second cavities separated by an impingement plate for flowing cooling medium for impingement cooling of nozzle side walls. The side wall of each nozzle segment has an undercut region. The impingement plate has an inturned flange with a plurality of openings. Cooling inserts or receptacles having an open end are received in the openings and the base and side walls of the receptacles have apertures for receiving cooling medium from the first cavity and directing the cooling medium for impingement cooling of the side wall of the nozzle segment and a portion of the nozzle wall.

  18. Segmented inlet nozzle for gas turbine, and methods of installation

    DOE Patents [OSTI]

    Klompas, Nicholas

    1985-01-01

    A gas turbine nozzle guide vane assembly is formed of individual arcuate nozzle segments. The arcuate nozzle segments are elastically joined to each other to form a complete ring, with edges abutted to prevent leakage. The resultant nozzle ring is included within the overall gas turbine stationary structure and secured by a mounting arrangement which permits relative radial movement at both the inner and outer mountings. A spline-type outer mounting provides circumferential retention. A complete rigid nozzle ring with freedom to "float" radially results. Specific structures are disclosed for the inner and outer mounting arrangements. A specific tie-rod structure is also disclosed for elastically joining the individual nozzle segments. Also disclosed is a method of assembling the nozzle ring subassembly-by-subassembly into a gas turbine employing temporary jacks.

  19. Documented Safety Analysis for the B695 Segment

    SciTech Connect (OSTI)

    Laycak, D

    2008-09-11

    This Documented Safety Analysis (DSA) was prepared for the Lawrence Livermore National Laboratory (LLNL) Building 695 (B695) Segment of the Decontamination and Waste Treatment Facility (DWTF). The report provides comprehensive information on design and operations, including safety programs and safety structures, systems and components to address the potential process-related hazards, natural phenomena, and external hazards that can affect the public, facility workers, and the environment. Consideration is given to all modes of operation, including the potential for both equipment failure and human error. The facilities known collectively as the DWTF are used by LLNL's Radioactive and Hazardous Waste Management (RHWM) Division to store and treat regulated wastes generated at LLNL. RHWM generally processes low-level radioactive waste with no, or extremely low, concentrations of transuranics (e.g., much less than 100 nCi/g). Wastes processed often contain only depleted uranium and beta- and gamma-emitting nuclides, e.g., {sup 90}Sr, {sup 137}Cs, or {sup 3}H. The mission of the B695 Segment centers on container storage, lab-packing, repacking, overpacking, bulking, sampling, waste transfer, and waste treatment. The B695 Segment is used for storage of radioactive waste (including transuranic and low-level), hazardous, nonhazardous, mixed, and other waste. Storage of hazardous and mixed waste in B695 Segment facilities is in compliance with the Resource Conservation and Recovery Act (RCRA). LLNL is operated by the Lawrence Livermore National Security, LLC, for the Department of Energy (DOE). The B695 Segment is operated by the RHWM Division of LLNL. Many operations in the B695 Segment are performed under a Resource Conservation and Recovery Act (RCRA) operation plan, similar to commercial treatment operations with best demonstrated available technologies. The buildings of the B695 Segment were designed and built considering such operations, using proven building systems

  20. UDEC (Universal Distinct Element Code) Version ICG1. 5

    SciTech Connect (OSTI)

    Board, M. )

    1989-09-01

    UDEC (Universal Distinct Element Code) is a two-dimensional distinct element program written for the static and dynamic analysis of the mechanical, thermal and hydrologic behavior of jointed rock masses. This program has been applied to a wide variety of problems in civil construction, mining, nuclear waste disposal, and geologic modeling. This document presents the theoretical basis for the mathematical models, the details of solution procedures, user's manual and presentation of verification and example problems. A description of the program support and documentation methodology which is employed is also given. This document is given in three volumes: This document, Volume 1 -- Description of mathematical models and numerical methods, and Volume 2 -- User's manual, and Volume 3 -- Verification and example problems. These three volumes are intended to satisfy the requirements and guidelines set forth in Final Technical Position and Documentation of computer Codes For High-Level Waste Management (NUREG-0856). 76 refs., 61 figs., 11 tabs.

  1. Distinct water activation on polar/non-polar facets of ZnO nanoparticl...

    Office of Scientific and Technical Information (OSTI)

    Distinct water activation on polarnon-polar facets of ZnO nanoparticles This content will become publicly available on September 14, 2017 Title: Distinct water activation on ...

  2. Method of making segmented pyrolytic graphite sputtering targets

    DOE Patents [OSTI]

    McKernan, Mark A.; Alford, Craig S.; Makowiecki, Daniel M.; Chen, Chih-Wen

    1994-01-01

    Anisotropic pyrolytic graphite wafers are oriented and bonded together such that the graphite's high thermal conductivity planes are maximized along the back surface of the segmented pyrolytic graphite target to allow for optimum heat conduction away from the sputter target's sputtering surface and to allow for maximum energy transmission from the target's sputtering surface.

  3. Decreasing transmembrane segment length greatly decreases perfringolysin O pore size

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lin, Qingqing; Li, Huilin; Wang, Tong; London, Erwin

    2015-04-08

    Perfringolysin O (PFO) is a transmembrane (TM) β-barrel protein that inserts into mammalian cell membranes. Once inserted into membranes, PFO assembles into pore-forming oligomers containing 30–50 PFO monomers. These form a pore of up to 300 Å, far exceeding the size of most other proteinaceous pores. In this study, we found that altering PFO TM segment length can alter the size of PFO pores. A PFO mutant with lengthened TM segments oligomerized to a similar extent as wild-type PFO, and exhibited pore-forming activity and a pore size very similar to wild-type PFO as measured by electron microscopy and a leakagemore » assay. In contrast, PFO with shortened TM segments exhibited a large reduction in pore-forming activity and pore size. This suggests that the interaction between TM segments can greatly affect the size of pores formed by TM β-barrel proteins. PFO may be a promising candidate for engineering pore size for various applications.« less

  4. Method of making segmented pyrolytic graphite sputtering targets

    DOE Patents [OSTI]

    McKernan, M.A.; Alford, C.S.; Makowiecki, D.M.; Chen, C.W.

    1994-02-08

    Anisotropic pyrolytic graphite wafers are oriented and bonded together such that the graphite's high thermal conductivity planes are maximized along the back surface of the segmented pyrolytic graphite target to allow for optimum heat conduction away from the sputter target's sputtering surface and to allow for maximum energy transmission from the target's sputtering surface. 2 figures.

  5. Decreasing transmembrane segment length greatly decreases perfringolysin O pore size

    SciTech Connect (OSTI)

    Lin, Qingqing; Li, Huilin; Wang, Tong; London, Erwin

    2015-04-08

    Perfringolysin O (PFO) is a transmembrane (TM) β-barrel protein that inserts into mammalian cell membranes. Once inserted into membranes, PFO assembles into pore-forming oligomers containing 30–50 PFO monomers. These form a pore of up to 300 Å, far exceeding the size of most other proteinaceous pores. In this study, we found that altering PFO TM segment length can alter the size of PFO pores. A PFO mutant with lengthened TM segments oligomerized to a similar extent as wild-type PFO, and exhibited pore-forming activity and a pore size very similar to wild-type PFO as measured by electron microscopy and a leakage assay. In contrast, PFO with shortened TM segments exhibited a large reduction in pore-forming activity and pore size. This suggests that the interaction between TM segments can greatly affect the size of pores formed by TM β-barrel proteins. PFO may be a promising candidate for engineering pore size for various applications.

  6. Microbial Populations in CAVES

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Microbial Populations in CAVES: A Comparison of Sulfur Biosignatures Annette Summers Engel, Department of Geology and Geophysics Compare Frasassi (Italy) and Lower Kane (Wyoming) CAVES

  7. Distinct photoresponse in graphene induced by laser irradiation

    SciTech Connect (OSTI)

    Wang, Wen Hui; Nan, Hai Yan; Liu, Qi; Ni, Zhen Hua; Liang, Zheng; Yu, Zhi Hao; Liu, Feng Yuan; Wang, Xin Ran; Hu, Wei Da; Zhang, Wei

    2015-01-12

    The graphene-based photodetector with tunable p-p{sup +}-p junctions was fabricated through a simple laser irradiation process. Distinct photoresponse was observed at the graphene (G)-laser irradiated graphene (LIG) junction by scanning photocurrent measurements, and its magnitude can be modulated as a result of a positive correlation between the photocurrent and doping concentration in LIG region. Detailed investigation suggests that the photo-thermoelectric effect, instead of the photovoltaic effect, dominates the photocurrent generation at the G-LIG junctions. Such a simple and low-cost technique offers an alternative way for the fabrication of graphene-based optoelectronic devices.

  8. Multi-region unstructured volume segmentation using tetrahedron filling

    SciTech Connect (OSTI)

    Willliams, Sean Jamerson; Dillard, Scott E; Thoma, Dan J; Hlawitschka, Mario; Hamann, Bernd

    2010-01-01

    Segmentation is one of the most common operations in image processing, and while there are several solutions already present in the literature, they each have their own benefits and drawbacks that make them well-suited for some types of data and not for others. We focus on the problem of breaking an image into multiple regions in a single segmentation pass, while supporting both voxel and scattered point data. To solve this problem, we begin with a set of potential boundary points and use a Delaunay triangulation to complete the boundaries. We use heuristic- and interaction-driven Voronoi clustering to find reasonable groupings of tetrahedra. Apart from the computation of the Delaunay triangulation, our algorithm has linear time complexity with respect to the number of tetrahedra.

  9. Segmented saddle-shaped passive stabilization conductors for toroidal plasmas

    DOE Patents [OSTI]

    Leuer, J.A.

    1990-05-01

    A large toroidal vacuum chamber for plasma generation and confinement is lined with a toroidal blanket for shielding using modules segmented in the toroidal direction. To provide passive stabilization in the same manner as a conductive vacuum chamber wall, saddle-shaped conductor loops are provided on blanket modules centered on a midplane of the toroidal chamber with horizontal conductive bars above and below the midplane, and vertical conductive legs on opposite sides of each module to provide return current paths between the upper and lower horizontal conductive bars. The close proximity of the vertical legs provided on adjacent modules without making physical contact cancel the electromagnetic field of adjacent vertical legs. The conductive bars spaced equally above and below the midplane simulate toroidal conductive loops or hoops that are continuous, for vertical stabilization of the plasma even though they are actually segmented. 5 figs.

  10. Measurements of Plasma Potential Distribution in Segmented Electrode Hall Thruster

    SciTech Connect (OSTI)

    Y. Raitses; D. Staack; N.J. Fisch

    2001-10-16

    Use of a segmented electrode placed at the Hall thruster exit can substantially reduce the voltage potential drop in the fringing magnetic field outside the thruster channel. In this paper, we investigate the dependence of this effect on thruster operating conditions and segmented electrode configuration. A fast movable emissive probe is used to measure plasma potential in a 1 kW laboratory Hall thruster with semented electrodes made of a graphite material. Relatively small probe-induced perturbations of the thruster discharge in the vicinity of the thruster exit allow a reasonable comparison of the measured results for different thruster configurations. It is shown that the plasma potential distribution is almost not sensitive to changes of the electrode potential, but depends on the magnetic field distribution and the electrode placement.

  11. Mask-Assisted Seeded Growth of Segmented Metallic Heteronanostructures

    SciTech Connect (OSTI)

    Crane, Cameron C.; Tao, Jing; Wang, Feng; Zhu, Yimei; Chen, Jingyi

    2014-12-04

    Controlling the deposition of exotic metals in the seeded growth of multi-metal nanostructures is challenging. This work describes a seeded growth method assisted by a mask for synthesis of segmented binary or ternary metal nanostructures. Silica is used as a mask to partially block the surface of a seed and a second metal is subsequently deposited on the exposed area, forming a bimetallic heterodimer. The initial demonstration was carried out on a Au seed, followed by deposition of Pd or Pt on the seed. It was found that Pd tends to spread out laterally on the seed while Pt inclines to grow vertically into branched topology on Au. Without removal of the SiO? mask, Pt could be further deposited on the unblocked Pd of the Pd-Au dimer to form a Pt-Pd-Au trimer. The mask-assisted seeded growth provides a general strategy to construct segmented metallic nanoarchitectures.

  12. Mask-Assisted Seeded Growth of Segmented Metallic Heteronanostructures

    SciTech Connect (OSTI)

    Crane, Cameron C.; Tao, Jing; Wang, Feng; Zhu, Yimei; Chen, Jingyi

    2014-12-04

    Controlling the deposition of exotic metals in the seeded growth of multi-metal nanostructures is challenging. This work describes a seeded growth method assisted by a mask for synthesis of segmented binary or ternary metal nanostructures. Silica is used as a mask to partially block the surface of a seed and a second metal is subsequently deposited on the exposed area, forming a bimetallic heterodimer. The initial demonstration was carried out on a Au seed, followed by deposition of Pd or Pt on the seed. It was found that Pd tends to spread out laterally on the seed while Pt inclines to grow vertically into branched topology on Au. Without removal of the SiO₂ mask, Pt could be further deposited on the unblocked Pd of the Pd-Au dimer to form a Pt-Pd-Au trimer. The mask-assisted seeded growth provides a general strategy to construct segmented metallic nanoarchitectures.

  13. Mask-Assisted Seeded Growth of Segmented Metallic Heteronanostructures

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Crane, Cameron C.; Tao, Jing; Wang, Feng; Zhu, Yimei; Chen, Jingyi

    2014-12-04

    Controlling the deposition of exotic metals in the seeded growth of multi-metal nanostructures is challenging. This work describes a seeded growth method assisted by a mask for synthesis of segmented binary or ternary metal nanostructures. Silica is used as a mask to partially block the surface of a seed and a second metal is subsequently deposited on the exposed area, forming a bimetallic heterodimer. The initial demonstration was carried out on a Au seed, followed by deposition of Pd or Pt on the seed. It was found that Pd tends to spread out laterally on the seed while Pt inclinesmore » to grow vertically into branched topology on Au. Without removal of the SiO₂ mask, Pt could be further deposited on the unblocked Pd of the Pd-Au dimer to form a Pt-Pd-Au trimer. The mask-assisted seeded growth provides a general strategy to construct segmented metallic nanoarchitectures.« less

  14. Lithium-drifted silicon detector with segmented contacts

    DOE Patents [OSTI]

    Tindall, Craig S.; Luke, Paul N.

    2006-06-13

    A method and apparatus for creating both segmented and unsegmented radiation detectors which can operate at room temperature. The devices include a metal contact layer, and an n-type blocking contact formed from a thin layer of amorphous semiconductor. In one embodiment the material beneath the n-type contact is n-type material, such as lithium compensated silicon that forms the active region of the device. The active layer has been compensated to a degree at which the device may be fully depleted at low bias voltages. A p-type blocking contact layer, or a p-type donor material can be formed beneath a second metal contact layer to complete the device structure. When the contacts to the device are segmented, the device is capable of position sensitive detection and spectroscopy of ionizing radiation, such as photons, electrons, and ions.

  15. Dual-circuit segmented rail phased induction motor

    DOE Patents [OSTI]

    Marder, Barry M.; Cowan, Jr., Maynard

    2002-01-01

    An improved linear motor utilizes two circuits, rather that one circuit and an opposed plate, to gain efficiency. The powered circuit is a flat conductive coil. The opposed segmented rail circuit is either a plurality of similar conductive coils that are shorted, or a plurality of ladders formed of opposed conductive bars connected by a plurality of spaced conductors. In each embodiment, the conductors are preferably cables formed from a plurality of intertwined insulated wires to carry current evenly.

  16. GPU-based relative fuzzy connectedness image segmentation

    SciTech Connect (OSTI)

    Zhuge Ying; Ciesielski, Krzysztof C.; Udupa, Jayaram K.; Miller, Robert W. [Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 (United States); Department of Mathematics, West Virginia University, Morgantown, West Virginia 26506 (United States) and Medical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Medical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 (United States)

    2013-01-15

    Purpose:Recently, clinical radiological research and practice are becoming increasingly quantitative. Further, images continue to increase in size and volume. For quantitative radiology to become practical, it is crucial that image segmentation algorithms and their implementations are rapid and yield practical run time on very large data sets. The purpose of this paper is to present a parallel version of an algorithm that belongs to the family of fuzzy connectedness (FC) algorithms, to achieve an interactive speed for segmenting large medical image data sets. Methods: The most common FC segmentations, optimizing an Script-Small-L {sub {infinity}}-based energy, are known as relative fuzzy connectedness (RFC) and iterative relative fuzzy connectedness (IRFC). Both RFC and IRFC objects (of which IRFC contains RFC) can be found via linear time algorithms, linear with respect to the image size. The new algorithm, P-ORFC (for parallel optimal RFC), which is implemented by using NVIDIA's Compute Unified Device Architecture (CUDA) platform, considerably improves the computational speed of the above mentioned CPU based IRFC algorithm. Results: Experiments based on four data sets of small, medium, large, and super data size, achieved speedup factors of 32.8 Multiplication-Sign , 22.9 Multiplication-Sign , 20.9 Multiplication-Sign , and 17.5 Multiplication-Sign , correspondingly, on the NVIDIA Tesla C1060 platform. Although the output of P-ORFC need not precisely match that of IRFC output, it is very close to it and, as the authors prove, always lies between the RFC and IRFC objects. Conclusions: A parallel version of a top-of-the-line algorithm in the family of FC has been developed on the NVIDIA GPUs. An interactive speed of segmentation has been achieved, even for the largest medical image data set. Such GPU implementations may play a crucial role in automatic anatomy recognition in clinical radiology.

  17. Automated matching and segmentation of lymphoma on serial CT examinations

    SciTech Connect (OSTI)

    Yan Jiayong; Zhao Binsheng; Curran, Sean; Zelenetz, Andrew; Schwartz, Lawrence H.

    2007-01-15

    In patients with lymphoma, identification and quantification of the tumor extent on serial CT examinations is critical for assessing tumor response to therapy. In this paper, we present a computer method to automatically match and segment lymphomas in follow-up CT images. The method requires that target lymph nodes in baseline CT images be known. A fast, approximate alignment technique along the x, y, and axial directions is developed to provide a good initial condition for the subsequent fast free form deformation (FFD) registration of the baseline and the follow-up images. As a result of the registration, the deformed lymph node contours from the baseline images are used to automatically determine internal and external markers for the marker-controlled watershed segmentation performed in the follow-up images. We applied this automated registration and segmentation method retrospectively to 29 lymph nodes in 9 lymphoma patients treated in a clinical trial at our cancer center. A radiologist independently delineated all lymph nodes on all slices in the follow-up images and his manual contours served as the ''gold standard'' for evaluation of the method. Preliminary results showed that 26/29 (89.7%) lymph nodes were correctly matched; i.e., there was a geometrical overlap between the deformed lymph node from the baseline and its corresponding mass in the follow-up images. Of the matched 26 lymph nodes, 22 (84.6%) were successfully segmented; for these 22 lymph nodes, several metrics were calculated to quantify the method's performance. Among them, the average distance and the Hausdorff distance between the contours generated by the computer and those generated by the radiologist were 0.9 mm (stdev. 0.4 mm) and 3.9 mm (stdev. 2.1 mm), respectively.

  18. Enhancing atlas based segmentation with multiclass linear classifiers

    SciTech Connect (OSTI)

    Sdika, Michaël

    2015-12-15

    Purpose: To present a method to enrich atlases for atlas based segmentation. Such enriched atlases can then be used as a single atlas or within a multiatlas framework. Methods: In this paper, machine learning techniques have been used to enhance the atlas based segmentation approach. The enhanced atlas defined in this work is a pair composed of a gray level image alongside an image of multiclass classifiers with one classifier per voxel. Each classifier embeds local information from the whole training dataset that allows for the correction of some systematic errors in the segmentation and accounts for the possible local registration errors. The authors also propose to use these images of classifiers within a multiatlas framework: results produced by a set of such local classifier atlases can be combined using a label fusion method. Results: Experiments have been made on the in vivo images of the IBSR dataset and a comparison has been made with several state-of-the-art methods such as FreeSurfer and the multiatlas nonlocal patch based method of Coupé or Rousseau. These experiments show that their method is competitive with state-of-the-art methods while having a low computational cost. Further enhancement has also been obtained with a multiatlas version of their method. It is also shown that, in this case, nonlocal fusion is unnecessary. The multiatlas fusion can therefore be done efficiently. Conclusions: The single atlas version has similar quality as state-of-the-arts multiatlas methods but with the computational cost of a naive single atlas segmentation. The multiatlas version offers a improvement in quality and can be done efficiently without a nonlocal strategy.

  19. A Segmented Drive System with a Small DC Bus Capacitor | Department of

    Broader source: Energy.gov (indexed) [DOE]

    Energy apep_08_su.pdf (346.73 KB) More Documents & Publications A Segmented Drive Inverter Topology with a Small DC Bus Capacitor A Segmented Drive Inverter Topology with a Small DC Bus Capacitor A Segmented Drive Inverter Topology with a Small DC Bus Capacitor

  20. Internal Josephson oscillations for distinct momenta Bose-Einstein condensates

    SciTech Connect (OSTI)

    Lim, Lih-King [Institute for Theoretical Physics, Utrecht University, Leuvenlaan 4, 3584 CE Utrecht (Netherlands); Laboratoire de Physique des Solides, CNRS UMR 8502, Universite Paris-Sud, F-91405 Orsay Cedex (France); Troppenz, T.; Morais Smith, C. [Institute for Theoretical Physics, Utrecht University, Leuvenlaan 4, 3584 CE Utrecht (Netherlands)

    2011-11-15

    The internal Josephson oscillations between an atomic Bose-Einstein condensate (BEC) and a molecular one are studied for atoms in a square optical lattice subjected to a staggered gauge field. The system is described by a Bose-Hubbard model with complex and anisotropic hopping parameters that are different for each species, i.e., atoms and molecules. When the flux per plaquette for each species is small, the system oscillates between two conventional zero-momentum condensates. However, there is a regime of parameters in which Josephson oscillations between a vortex-carrying atomic condensate (finite momentum BEC) and a conventional zero-momentum molecular condensate may be realized. The experimental observation of the oscillations between these qualitatively distinct BEC's is possible with state-of-the-art Ramsey interference techniques.

  1. Distinct magnetic signatures of fractional vortex configurations in multiband superconductors

    SciTech Connect (OSTI)

    Silva, R. M. da; Domnguez, D.; Aguiar, J. Albino

    2014-12-08

    Vortices carrying fractions of a flux quantum are predicted to exist in multiband superconductors, where vortex core can split between multiple band-specific components of the superconducting condensate. Using the two-component Ginzburg-Landau model, we examine such vortex configurations in a two-band superconducting slab in parallel magnetic field. The fractional vortices appear due to the band-selective vortex penetration caused by different thresholds for vortex entry within each band-condensate, and stabilize near the edges of the sample. We show that the resulting fractional vortex configurations leave distinct fingerprints in the static measurements of the magnetization, as well as in ac dynamic measurements of the magnetic susceptibility, both of which can be readily used for the detection of these fascinating vortex states in several existing multiband superconductors.

  2. Separation of distinct photoexcitation species in femtosecond transient absorption microscopy

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xiao, Kai; Ma, Ying -Zhong; Simpson, Mary Jane; Doughty, Benjamin; Yang, Bing

    2016-02-03

    Femtosecond transient absorption microscopy is a novel chemical imaging capability with simultaneous high spatial and temporal resolution. Although several powerful data analysis approaches have been developed and successfully applied to separate distinct chemical species in such images, the application of such analysis to distinguish different photoexcited species is rare. In this paper, we demonstrate a combined approach based on phasor and linear decomposition analysis on a microscopic level that allows us to separate the contributions of both the excitons and free charge carriers in the observed transient absorption response of a composite organometallic lead halide perovskite film. We found spatialmore » regions where the transient absorption response was predominately a result of excitons and others where it was predominately due to charge carriers, and regions consisting of signals from both contributors. Lastly, quantitative decomposition of the transient absorption response curves further enabled us to reveal the relative contribution of each photoexcitation to the measured response at spatially resolved locations in the film.« less

  3. Microstructure and thermomechanical properties relationship of segmented thermoplastic polyurethane (TPU)

    SciTech Connect (OSTI)

    Frick, Achim, E-mail: achim.frick@htw-aalen.de; Borm, Michael, E-mail: achim.frick@htw-aalen.de; Kaoud, Nouran, E-mail: achim.frick@htw-aalen.de; Kolodziej, Jan, E-mail: achim.frick@htw-aalen.de; Neudeck, Jens, E-mail: achim.frick@htw-aalen.de [Institute of Polymer Science and Processing (iPSP), HTW Aalen (Germany)

    2014-05-15

    Thermoplastic polyurethanes (TPU) are important polymeric materials for seals. In competition with Acrylonitrile butadiene rubbers (NBR), TPU exhibits higher strength and a considerable better abrasion resistance. The advantage of NBR over TPU is a smaller compression set but however TPU excels in its much shorter processing cycle times. Generally a TPU is a block copolymer composed of hard and soft segments, which plays an important role in determining the material properties. TPU can be processed either to ready moulded parts or can be incorporated by multi component moulding, in both cases it shows decent mechanical properties. In the present work, the relationship between melt-process induced TPU morphology and resultant thermo mechanical properties were examined and determined by means of quasi-static tensile test, creep experiment, tension test and dynamical mechanical analysis (DMA). Scanning electron beam microscope (SEM) and differential scanning calorimeter (DSC) were used to study the morphology of the samples. A significant mathematical description of the stress-strain behaviour of TPU was found using a 3 term approach. Moreover it became evident that processing conditions such as processing temperature have crucial influence on morphology as well as short and long-term performance. To be more precise, samples processed at higher temperatures showed a lack of large hard segment agglomerates, a smaller strength for strains up to 250% and higher creep compliance.

  4. Proximity graphs based multi-scale image segmentation

    SciTech Connect (OSTI)

    Skurikhin, Alexei N

    2008-01-01

    We present a novel multi-scale image segmentation approach based on irregular triangular and polygonal tessellations produced by proximity graphs. Our approach consists of two separate stages: polygonal seeds generation followed by an iterative bottom-up polygon agglomeration into larger chunks. We employ constrained Delaunay triangulation combined with the principles known from the visual perception to extract an initial ,irregular polygonal tessellation of the image. These initial polygons are built upon a triangular mesh composed of irregular sized triangles and their shapes are ad'apted to the image content. We then represent the image as a graph with vertices corresponding to the polygons and edges reflecting polygon relations. The segmentation problem is then formulated as Minimum Spanning Tree extraction. We build a successive fine-to-coarse hierarchy of irregular polygonal grids by an iterative graph contraction constructing Minimum Spanning Tree. The contraction uses local information and merges the polygons bottom-up based on local region-and edge-based characteristics.

  5. Quant-CT: Segmenting and Quantifying Computed Tomography

    Energy Science and Technology Software Center (OSTI)

    2011-10-01

    Quant-CT is currently a plugin to ImageJ, designed as a Java-class that provides control mechanism for the user to choose volumes of interest within porous material, followed by the selection of image subsamples for automated tuning of parameters for filters and classifiers, and finally measurement of material geometry, porosity, and visualization. Denoising is mandatory before any image interpretation, and we implemented a new 3D java code that performs bilateral filtering of data. Segmentation of themore » dense material is essential before any quantifications about geological sample structure, and we invented new schemes to deal with over segmentation when using statistical region merging algorithm to pull out grains that compose imaged material. It make uses of ImageJ API and other standard and thirty-party APIs. Quant-CT conception started in 2011 under Scidac-e sponsor, and details of the first prototype were documented in publications below. While it is used right now for microtomography images, it can potentially be used by anybody with 3D image data obtained by experiment or produced by simulation.« less

  6. Observation of two distinct negative trions in tungsten disulfide monolayers

    SciTech Connect (OSTI)

    Boulesbaa, Abdelaziz; Huang, Bing; Wang, Kai; Lin, Ming-Wei; Mahjouri-Samani, Masoud; Rouleau, Christopher M.; Xiao, Kai; Yoon, Mina; Sumpter, Bobby G.; Puretzky, Alexander A.; Geohegan, David B.

    2015-09-25

    We report on the observation of two distinct photogenerated negative trion states TA and TB in two-dimensional tungsten disulfide (2D-WS2) monolayers. These trions are postulated to emerge from their parent excitons XA and XB, which originate from spin-orbit-split (SOS) levels in the conduction band (CB) and valence band (VB). Time-resolved spectroscopy measurements suggests that Pauli blocking controls a competition process between TA and TB photoformation, following dissociation of XA and XB through hole trapping at internal or substrate defect sites. While TA arises directly from its parent XA, TB emerges through a different transition accessible only after XB dissociates through a hole trapping channel. This discovery of additional optically-active band-edge transitions in atomically-thin metal dichalcogenides may revolutionize optoelectronic applications and fundamental research opportunities for many-body interaction physics. Ultrafast pump-probe spectroscopy of two-dimensional tungsten disulfide monolayers (2D-WS2) grown on sapphire substrates revealed two transient absorption spectral peaks that are attributed to distinct negative trions at ~2.02 eV (T1) and ~1.98 eV (T2). The dynamics measurements indicate that trion formation by the probe is enabled by photodoped electrons that remain after trapping of holes from excitons or free electron-hole pairs at defect sites in the crystal or on the substrate. Dynamics of the excitons XA and XB’s characteristic absorption bands, at ~2.03 and ~2.40 eV, respectively, were separately monitored and compared with the photoinduced absorption features. Selective excitation of the lowest exciton level XA using λpump < 2.4 eV forms only trion T1, which implies that the electron that remains

  7. Observation of two distinct negative trions in tungsten disulfide monolayers

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Boulesbaa, Abdelaziz; Huang, Bing; Wang, Kai; Lin, Ming-Wei; Mahjouri-Samani, Masoud; Rouleau, Christopher M.; Xiao, Kai; Yoon, Mina; Sumpter, Bobby G.; Puretzky, Alexander A.; et al

    2015-09-25

    We report on the observation of two distinct photogenerated negative trion states TA and TB in two-dimensional tungsten disulfide (2D-WS2) monolayers. These trions are postulated to emerge from their parent excitons XA and XB, which originate from spin-orbit-split (SOS) levels in the conduction band (CB) and valence band (VB). Time-resolved spectroscopy measurements suggests that Pauli blocking controls a competition process between TA and TB photoformation, following dissociation of XA and XB through hole trapping at internal or substrate defect sites. While TA arises directly from its parent XA, TB emerges through a different transition accessible only after XB dissociates throughmore » a hole trapping channel. This discovery of additional optically-active band-edge transitions in atomically-thin metal dichalcogenides may revolutionize optoelectronic applications and fundamental research opportunities for many-body interaction physics. Ultrafast pump-probe spectroscopy of two-dimensional tungsten disulfide monolayers (2D-WS2) grown on sapphire substrates revealed two transient absorption spectral peaks that are attributed to distinct negative trions at ~2.02 eV (T1) and ~1.98 eV (T2). The dynamics measurements indicate that trion formation by the probe is enabled by photodoped electrons that remain after trapping of holes from excitons or free electron-hole pairs at defect sites in the crystal or on the substrate. Dynamics of the excitons XA and XB’s characteristic absorption bands, at ~2.03 and ~2.40 eV, respectively, were separately monitored and compared with the photoinduced absorption features. Selective excitation of the lowest exciton level XA using λpump < 2.4 eV forms only trion T1, which implies that the electron that remains from the dissociation of exciton XA is involved in the creation of this trion with a binding energy ~ 10 meV with respect to XA. The absorption peak that corresponds to trion T2 appears when λpump > 2.4 eV, which is just

  8. Population attribute compression

    DOE Patents [OSTI]

    White, James M.; Faber, Vance; Saltzman, Jeffrey S.

    1995-01-01

    An image population having a large number of attributes is processed to form a display population with a predetermined smaller number of attributes that represent the larger number of attributes. In a particular application, the color values in an image are compressed for storage in a discrete look-up table (LUT). Color space containing the LUT color values is successively subdivided into smaller volumes until a plurality of volumes are formed, each having no more than a preselected maximum number of color values. Image pixel color values can then be rapidly placed in a volume with only a relatively few LUT values from which a nearest neighbor is selected. Image color values are assigned 8 bit pointers to their closest LUT value whereby data processing requires only the 8 bit pointer value to provide 24 bit color values from the LUT.

  9. Turbine stator vane segment having internal cooling circuits

    DOE Patents [OSTI]

    Jones, Raymond Joseph; Burns, James Lee; Bojappa, Parvangada Ganapathy; Jones, Schotsch Margaret

    2003-01-01

    A turbine stator vane includes outer and inner walls each having outer and inner chambers and a vane extending between the outer and inner walls. The vane includes first, second, third, fourth and fifth cavities for flowing a cooling medium. The cooling medium enters the outer chamber of the outer wall, flows through an impingement plate for impingement cooling of the outer band wall defining in part the hot gas path and through openings in the first, second and fourth cavities for flow radially inwardly, cooling the vane. The spent cooling medium flows into the inner wall and inner chamber for flow through an impingement plate radially outwardly to cool the inner wall. The spent cooling medium flows through the third cavity for egress from the turbine vane segment from the outer wall. The first, second or third cavities contain inserts having impingement openings for impingement cooling of the vane walls. The fifth cavity provides air cooling for the trailing edge.

  10. 2-D image segmentation using minimum spanning trees

    SciTech Connect (OSTI)

    Xu, Y.; Uberbacher, E.C.

    1995-09-01

    This paper presents a new algorithm for partitioning a gray-level image into connected homogeneous regions. The novelty of this algorithm lies in the fact that by constructing a minimum spanning tree representation of a gray-level image, it reduces a region partitioning problem to a minimum spanning tree partitioning problem, and hence reduces the computational complexity of the region partitioning problem. The tree-partitioning algorithm, in essence, partitions a minimum spanning tree into subtrees, representing different homogeneous regions, by minimizing the sum of variations of gray levels over all subtrees under the constraints that each subtree should have at least a specified number of nodes, and two adjacent subtrees should have significantly different average gray-levels. Two (faster) heuristic implementations are also given for large-scale region partitioning problems. Test results have shown that the segmentation results are satisfactory and insensitive to noise.

  11. Segmentation-free empirical beam hardening correction for CT

    SciTech Connect (OSTI)

    Schller, Sren; Sawall, Stefan; Stannigel, Kai; Hlsbusch, Markus; Ulrici, Johannes; Hell, Erich; Kachelrie, Marc

    2015-02-15

    Purpose: The polychromatic nature of the x-ray beams and their effects on the reconstructed image are often disregarded during standard image reconstruction. This leads to cupping and beam hardening artifacts inside the reconstructed volume. To correct for a general cupping, methods like water precorrection exist. They correct the hardening of the spectrum during the penetration of the measured object only for the major tissue class. In contrast, more complex artifacts like streaks between dense objects need other techniques of correction. If using only the information of one single energy scan, there are two types of corrections. The first one is a physical approach. Thereby, artifacts can be reproduced and corrected within the original reconstruction by using assumptions in a polychromatic forward projector. These assumptions could be the used spectrum, the detector response, the physical attenuation and scatter properties of the intersected materials. A second method is an empirical approach, which does not rely on much prior knowledge. This so-called empirical beam hardening correction (EBHC) and the previously mentioned physical-based technique are both relying on a segmentation of the present tissues inside the patient. The difficulty thereby is that beam hardening by itself, scatter, and other effects, which diminish the image quality also disturb the correct tissue classification and thereby reduce the accuracy of the two known classes of correction techniques. The herein proposed method works similar to the empirical beam hardening correction but does not require a tissue segmentation and therefore shows improvements on image data, which are highly degraded by noise and artifacts. Furthermore, the new algorithm is designed in a way that no additional calibration or parameter fitting is needed. Methods: To overcome the segmentation of tissues, the authors propose a histogram deformation of their primary reconstructed CT image. This step is essential for the

  12. POPULATION III HYPERNOVAE

    SciTech Connect (OSTI)

    Smidt, Joseph; Whalen, Daniel J.; Wiggins, Brandon K.; Even, Wesley; Fryer, Chris L.; Johnson, Jarrett L.

    2014-12-20

    Population III supernovae have been of growing interest of late for their potential to directly probe the properties of the first stars, particularly the most energetic events that are visible near the edge of the observable universe. Until now, hypernovae, the unusually energetic Type Ib/c supernovae that are sometimes associated with gamma-ray bursts, have been overlooked as cosmic beacons at the highest redshifts. In this, the latest of a series of studies on Population III supernovae, we present numerical simulations of 25-50 M {sub ☉} hypernovae and their light curves done with the Los Alamos RAGE and SPECTRUM codes. We find that they will be visible at z = 10-15 to the James Webb Space Telescope and z = 4-5 to the Wide-Field Infrared Survey Telescope, tracing star formation rates in the first galaxies and at the end of cosmological reionization. If, however, the hypernova crashes into a dense shell ejected by its progenitor, it is expected that a superluminous event will occur that may be seen at z ∼ 20 in the first generation of stars.

  13. Population Density by County, 2000

    SciTech Connect (OSTI)

    2009-01-18

    Map showing a United States profile including race, population by sex and age, housing tenure, and more.

  14. Investigation into the use of market segmentation analysis in transportation energy planning

    SciTech Connect (OSTI)

    Trombly, J.W.

    1985-01-01

    This research explores the application of market-segmentation analysis in transportation energy planning. The study builds on the concepts of market segmentation developed in the marketing literature to suggest a strategy of segmentation analysis for use in transportation planning. Results of the two statewide telephone surveys conducted in 1979 and 1980 for the New York State Department of Transportation are used as the data base for identifying target segments. Subjects in these surveys were asked to indicate which of 18 energy conservation actions had been implemented over the prior year to conserve gasoline. These responses serve as the basis for segmentation. Two alternative methods are pursued in identifying target market segments for purposes of transportation energy planning. The first approach consists of the application of conventional multivariate analysis procedures. The second method exploits the principles of latent trait or modern test theory. Results of the conventional analysis suggest that the data collected can be divided into eight segments. Results of the application of latent trait theory identify three market segments. Results of this study may be used to design future responses to energy shortages in addition to suggesting strategies to be pursued in measuring consumer response.

  15. DETECTION OF A DISTINCT METAL-POOR STELLAR HALO IN THE EARLY-TYPE GALAXY NGC3115

    SciTech Connect (OSTI)

    Peacock, Mark B.; Strader, Jay; Romanowsky, Aaron J.; Brodie, Jean P.

    2015-02-10

    We present the resolved stellar populations in the inner and outer halo of the nearby lenticular galaxy NGC3115. Using deep Hubble Space Telescope observations, we analyze stars 2 mag fainter than the tip of the red giant branch (TRGB). We study three fields along the minor axis of this galaxy, 19, 37, and 54kpc from its centercorresponding to 7, 14, and 21 effective radii (r{sub e} ). Even at these large galactocentric distances, all of the fields are dominated by a relatively enriched population, with the main peak in the metallicity distribution decreasing with radius from [Z/H] ? 0.5 to 0.65. The fraction of metal-poor stars ([Z/H] < 0.95) increases from 17% at 16-37 kpc to 28% at ?54kpc. We observe a distinct low-metallicity population (peaked at [Z/H] ? 1.3 and with total mass 2 10{sup 10} M {sub ?} ? 14% of the galaxy's stellar mass) and argue that this represents the detection of an underlying low-metallicity stellar halo. Such halos are generally predicted by galaxy formation theories and have been observed in several late-type galaxies, including the Milky Way and M31. The metallicity and spatial distribution of the stellar halo of NGC3115 are consistent with the galaxy's globular cluster system, which has a similar low-metallicity population that becomes dominant at these large radii. This finding supports the use of globular clusters as bright chemodynamical tracers of galaxy halos. These data also allow us to make a precise measurement of the magnitude of the TRGB, from which we derive a distance modulus of NGC3115 of 30.05 0.05 0.10{sub sys} (10.2 0.2 0.5{sub sys}Mpc)

  16. Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream

    DOE Patents [OSTI]

    Jacobson, Stephen C [Knoxville, TN; Ramsey, J Michael [Knoxville, TN

    2008-09-09

    A microfluidic device and method for forming and dispensing minute volume segments of a material are described. In accordance with the present invention, a microfluidic device and method are provided for spatially confining the material in a focusing element. The device is also adapted for segmenting the confined material into minute volume segments, and dispensing a volume segment to a waste or collection channel. The device further includes means for driving the respective streams of sample and focusing fluids through respective channels into a chamber, such that the focusing fluid streams spatially confine the sample material. The device may also include additional means for driving a minute volume segment of the spatially confined sample material into a collection channel in fluid communication with the waste reservoir.

  17. Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream

    DOE Patents [OSTI]

    Jacobson, Stephen C.; Ramsey, J. Michael

    2004-09-14

    A microfluidic device for forming and/or dispensing minute volume segments of a material is described. In accordance with one aspect of the present invention, a microfluidic device and method is provided for spatially confining the material in a focusing element. The device is also capable of segmenting the confined material into minute volume segments, and dispensing a volume segment to a waste or collection channel. The device further includes means for driving the respective streams of sample and focusing fluids through respective channels into a chamber, such that the focusing fluid streams spatially confine the sample material. The device may also include additional means for driving a minute volume segment of the spatially confined sample material into a collection channel in fluid communication with the waste reservoir.

  18. Adaptive Breast Radiation Therapy Using Modeling of Tissue Mechanics: A Breast Tissue Segmentation Study

    SciTech Connect (OSTI)

    Juneja, Prabhjot; Harris, Emma J.; Kirby, Anna M.; Evans, Philip M.

    2012-11-01

    Purpose: To validate and compare the accuracy of breast tissue segmentation methods applied to computed tomography (CT) scans used for radiation therapy planning and to study the effect of tissue distribution on the segmentation accuracy for the purpose of developing models for use in adaptive breast radiation therapy. Methods and Materials: Twenty-four patients receiving postlumpectomy radiation therapy for breast cancer underwent CT imaging in prone and supine positions. The whole-breast clinical target volume was outlined. Clinical target volumes were segmented into fibroglandular and fatty tissue using the following algorithms: physical density thresholding; interactive thresholding; fuzzy c-means with 3 classes (FCM3) and 4 classes (FCM4); and k-means. The segmentation algorithms were evaluated in 2 stages: first, an approach based on the assumption that the breast composition should be the same in both prone and supine position; and second, comparison of segmentation with tissue outlines from 3 experts using the Dice similarity coefficient (DSC). Breast datasets were grouped into nonsparse and sparse fibroglandular tissue distributions according to expert assessment and used to assess the accuracy of the segmentation methods and the agreement between experts. Results: Prone and supine breast composition analysis showed differences between the methods. Validation against expert outlines found significant differences (P<.001) between FCM3 and FCM4. Fuzzy c-means with 3 classes generated segmentation results (mean DSC = 0.70) closest to the experts' outlines. There was good agreement (mean DSC = 0.85) among experts for breast tissue outlining. Segmentation accuracy and expert agreement was significantly higher (P<.005) in the nonsparse group than in the sparse group. Conclusions: The FCM3 gave the most accurate segmentation of breast tissues on CT data and could therefore be used in adaptive radiation therapy-based on tissue modeling. Breast tissue segmentation

  19. The impacts of population change on carbon emissions in China during 1978-2008

    SciTech Connect (OSTI)

    Zhu Qin Peng Xizhe

    2012-09-15

    This study examines the impacts of population size, population structure, and consumption level on carbon emissions in China from 1978 to 2008. To this end, we expanded the stochastic impacts by regression on population, affluence, and technology model and used the ridge regression method, which overcomes the negative influences of multicollinearity among independent variables under acceptable bias. Results reveal that changes in consumption level and population structure were the major impact factors, not changes in population size. Consumption level and carbon emissions were highly correlated. In terms of population structure, urbanization, population age, and household size had distinct effects on carbon emissions. Urbanization increased carbon emissions, while the effect of age acted primarily through the expansion of the labor force and consequent overall economic growth. Shrinking household size increased residential consumption, resulting in higher carbon emissions. Households, rather than individuals, are a more reasonable explanation for the demographic impact on carbon emissions. Potential social policies for low carbon development are also discussed. - Highlights: Black-Right-Pointing-Pointer We examine the impacts of population change on carbon emissions in China. Black-Right-Pointing-Pointer We expand the STIRPAT model by containing population structure factors in the model. Black-Right-Pointing-Pointer The population structure includes age structure, urbanization level, and household size. Black-Right-Pointing-Pointer The ridge regression method is used to estimate the model with multicollinearity. Black-Right-Pointing-Pointer The population structure plays a more important role compared with the population size.

  20. Determination of lung segments in computed tomography images using the Euclidean distance to the pulmonary artery

    SciTech Connect (OSTI)

    Stoecker, Christina; Moltz, Jan H.; Lassen, Bianca; Kuhnigk, Jan-Martin; Krass, Stefan; Welter, Stefan; Peitgen, Heinz-Otto

    2013-09-15

    Purpose: Computed tomography (CT) imaging is the modality of choice for lung cancer diagnostics. With the increasing number of lung interventions on sublobar level in recent years, determining and visualizing pulmonary segments in CT images and, in oncological cases, reliable segment-related information about the location of tumors has become increasingly desirable. Computer-assisted identification of lung segments in CT images is subject of this work.Methods: The authors present a new interactive approach for the segmentation of lung segments that uses the Euclidean distance of each point in the lung to the segmental branches of the pulmonary artery. The aim is to analyze the potential of the method. Detailed manual pulmonary artery segmentations are used to achieve the best possible segment approximation results. A detailed description of the method and its evaluation on 11 CT scans from clinical routine are given.Results: An accuracy of 2–3 mm is measured for the segment boundaries computed by the pulmonary artery-based method. On average, maximum deviations of 8 mm are observed. 135 intersegmental pulmonary veins detected in the 11 test CT scans serve as reference data. Furthermore, a comparison of the presented pulmonary artery-based approach to a similar approach that uses the Euclidean distance to the segmental branches of the bronchial tree is presented. It shows a significantly higher accuracy for the pulmonary artery-based approach in lung regions at least 30 mm distal to the lung hilum.Conclusions: A pulmonary artery-based determination of lung segments in CT images is promising. In the tests, the pulmonary artery-based determination has been shown to be superior to the bronchial tree-based determination. The suitability of the segment approximation method for application in the planning of segment resections in clinical practice has already been verified in experimental cases. However, automation of the method accompanied by an evaluation on a larger

  1. Genome-wide Selective Sweeps in Natural Bacterial Populations Revealed by Time-series Metagenomics

    SciTech Connect (OSTI)

    Chan, Leong-Keat; Bendall, Matthew L.; Malfatti, Stephanie; Schwientek, Patrick; Tremblay, Julien; Schackwitz, Wendy; Martin, Joel; Pati, Amrita; Bushnell, Brian; Foster, Brian; Kang, Dongwan; Tringe, Susannah G.; Bertilsson, Stefan; Moran, Mary Ann; Shade, Ashley; Newton, Ryan J.; Stevens, Sarah; McMcahon, Katherine D.; Mamlstrom, Rex R.

    2014-05-12

    Multiple evolutionary models have been proposed to explain the formation of genetically and ecologically distinct bacterial groups. Time-series metagenomics enables direct observation of evolutionary processes in natural populations, and if applied over a sufficiently long time frame, this approach could capture events such as gene-specific or genome-wide selective sweeps. Direct observations of either process could help resolve how distinct groups form in natural microbial assemblages. Here, from a three-year metagenomic study of a freshwater lake, we explore changes in single nucleotide polymorphism (SNP) frequencies and patterns of gene gain and loss in populations of Chlorobiaceae and Methylophilaceae. SNP analyses revealed substantial genetic heterogeneity within these populations, although the degree of heterogeneity varied considerably among closely related, co-occurring Methylophilaceae populations. SNP allele frequencies, as well as the relative abundance of certain genes, changed dramatically over time in each population. Interestingly, SNP diversity was purged at nearly every genome position in one of the Chlorobiaceae populations over the course of three years, while at the same time multiple genes either swept through or were swept from this population. These patterns were consistent with a genome-wide selective sweep, a process predicted by the ecotype model? of diversification, but not previously observed in natural populations.

  2. A new zinc-1,3,5-benzenetricarboxylate framework integrated three distinct subunits (SBUs)

    SciTech Connect (OSTI)

    Xie, Yi-Ming

    2013-06-01

    A new metal-organic framework (MOF) [Zn₅(btc)₃(H₂O)₀.₅(O)₀.₅(DMA)₃]·1.75(DMA) (1; btc=1,3,5-benzenetricarboxylate; DMA=N,N´-dimethyl acetamide) has been solvothermally synthesized. Unusually, three distinct subunits (SBUs), [Zn₂(CO₂)₄(DMA)₂], [(μ₃-H₂O)Zn₃(CO₂)₆(DMA)] and [(µ₄-O)Zn₄(CO₂)₆(DMA)₂] are observed in 1 simultaneously. The integration of three distinct SBUs leads to an interesting Zn-btc framework materials with unusual structural topology. - Graphical abstract: Presented here is a new zinc-1,3,5-benzenetricarboxylate framework integrated three distinct subunits (SBUs). - Highlights: • A new zinc-1,3,5-benzenetricarboxylate framework has been synthesized. • Three distinct subunits (SBUs) are observed in 1 simultaneously. • The integration of three distinct SBUs leads to an unusual structural topology.

  3. Segmental shell for a coal crusher roll including specialized removal means

    SciTech Connect (OSTI)

    Gundlach, T.F.

    1986-10-21

    The patent describes a coal crusher having a cylindrical back-up roll having two ends, an outside face, a longitudinal axis, and a hub mounted in each end of the back-up roll. The coal crusher includes a combination of removable toothed segments mounted to the outside face of the roll and hook means including a tang for removing the segments from the roll. The coal crusher comprises metal segments, each of the segments in the form of a sector of a tube. The segment has an inside face and an outside face and an outside peripheral edge. The edge includes upper and lower axially extending edges, and two circumferential edges. The inside face of the segment has a radius of curvature substantially equal to the radius of curvature of the outside face of the back-up roll and has counterbored holes therein for receiving headed bolts which are threaded into tapped holes in the back-up roll to secure the segments to the back-up roll. Each of the counterbored holes has a seat to receive the heads of the bolts.

  4. SpArcFiRe: Scalable automated detection of spiral galaxy arm segments

    SciTech Connect (OSTI)

    Davis, Darren R.; Hayes, Wayne B. E-mail: whayes@uci.edu

    2014-08-01

    Given an approximately centered image of a spiral galaxy, we describe an entirely automated method that finds, centers, and sizes the galaxy (possibly masking nearby stars and other objects if necessary in order to isolate the galaxy itself) and then automatically extracts structural information about the spiral arms. For each arm segment found, we list the pixels in that segment, allowing image analysis on a per-arm-segment basis. We also perform a least-squares fit of a logarithmic spiral arc to the pixels in that segment, giving per-arc parameters, such as the pitch angle, arm segment length, location, etc. The algorithm takes about one minute per galaxies, and can easily be scaled using parallelism. We have run it on all ?644,000 Sloan objects that are larger than 40 pixels across and classified as 'galaxies'. We find a very good correlation between our quantitative description of a spiral structure and the qualitative description provided by Galaxy Zoo humans. Our objective, quantitative measures of structure demonstrate the difficulty in defining exactly what constitutes a spiral 'arm', leading us to prefer the term 'arm segment'. We find that pitch angle often varies significantly segment-to-segment in a single spiral galaxy, making it difficult to define the pitch angle for a single galaxy. We demonstrate how our new database of arm segments can be queried to find galaxies satisfying specific quantitative visual criteria. For example, even though our code does not explicitly find rings, a good surrogate is to look for galaxies having one long, low-pitch-angle armwhich is how our code views ring galaxies. SpArcFiRe is available at http://sparcfire.ics.uci.edu.

  5. DOE Launches First Segment of its Next-Generation Nationwide Network to

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Support Scientific Research Efforts | Department of Energy First Segment of its Next-Generation Nationwide Network to Support Scientific Research Efforts DOE Launches First Segment of its Next-Generation Nationwide Network to Support Scientific Research Efforts May 30, 2007 - 1:24pm Addthis WASHINGTON, DC- The U.S. Department of Energy's (DOE) Office of Science and Internet2 announced today that the first segment of a next-generation, nationwide network has gone live, marking a key step in

  6. Genetic population structure of chinook salmon, oncorhynchus tshawytscha, in the Pacific Northwest

    SciTech Connect (OSTI)

    Utter, F.; Milner, G.; Teel, D. ); Stahl, G. )

    1989-04-01

    Variation at 25 polymorphic protein coding loci was examined for 86 populations of chinook salmon, Oncorhynchus tshawytscha, ranging from the Babine River Columbia to the Sacramento River in California. Substantial differences in allele frequencies identified patterns of genetic variability over the geographic range of the study. Nine major genetically defined regions were formulated. Populations sampled within a region tended to be genetically distinct from each other although they exhibited the general patterns of variability that defined the region. Within a region there was little distinction among populations returning to spawn at different times. The persistence of these geographic patterns in the face of natural opportunities for introgression, and sometimes massive transplantations, suggests that genetically adapted groups within regions have resisted large-scale introgression from other regions. Repopulation of deglaciated areas in the Fraser River, Georgia Strait, and Puget Sound apparently occurred from multiple sources; most likely sources included Columbia River populations and northern refuges rather than from the large coastal group of populations. Patterns of genetic distribution of chinook salmon differed from those of other anadromous salmonids studied within this region. A conservative policy for stock transfers was suggested based on distinct genetic differences observed both between and within regions.

  7. Energetic neutral atoms measured by the interstellar boundary explorer (IBEX): Evidence for multiple heliosheath populations

    SciTech Connect (OSTI)

    Desai, M. I.; Allegrini, F. A.; Dayeh, M. A.; Fuselier, S. A.; McComas, D. J.; Bzowski, M.; Kubiak, M. A.; Sok?, J. M.; Funsten, H.; Heerikhuisen, J.; Pogorelov, N. V.; Zank, G. P.; Zirnstein, E. J.; Schwadron, N. A.

    2014-01-01

    Energetic neutral atoms (ENAs) observed by the Interstellar Boundary Explorer (IBEX) provide powerful diagnostics about the origin of the progenitor ion populations and the physical mechanisms responsible for their production. In this paper, we extend the work of Desai et al. and Fuselier et al. and combine and compare ENA spectra from the first 3 yr of observations by the IBEX-Hi and -Lo ENA imagers along the lines-of-sight (LOSs) from the inner heliosphere through to the locations of Voyager 1 and 2 with results from an updated physics-based model of the three-dimensional heliosphere and its constituent ion populations. Our results show that (1) IBEX ENA fluxes and spectra above ?0.7 keV measured along the LOSs of the Voyagers are consistent with several models in which the parent pickup ion (PUI) populations originate in the inner heliosheath, and (2) a significant fraction of lower energy ENAs between ?0.1-0.5 keV may originate from interstellar neutral gas charge-exchanging with a non-thermalized (hot) population of PUIs in the outer heliosheath beyond the heliopause. We discuss the implications of ENAs observed by IBEX originating from distinct parent populations as well as from two distinct locations in the heliospheric interface. These results indicate that ENA spectral measurements at various energies can be used to remotely probe distinct physical processes operating in vastly different regions of the distant heliosphere.

  8. The differing magnitude distributions of the two Jupiter Trojan color populations

    SciTech Connect (OSTI)

    Wong, Ian; Brown, Michael E.; Emery, Joshua P.

    2014-12-01

    The Jupiter Trojans are a significant population of minor bodies in the middle solar system that have garnered substantial interest in recent years. Several spectroscopic studies of these objects have revealed notable bimodalities with respect to near-infrared spectra, infrared albedo, and color, which suggest the existence of two distinct groups among the Trojan population. In this paper, we analyze the magnitude distributions of these two groups, which we refer to as the red and less red color populations. By compiling spectral and photometric data from several previous works, we show that the observed bimodalities are self-consistent and categorize 221 of the 842 Trojans with absolute magnitudes in the range H<12.3 into the two color populations. We demonstrate that the magnitude distributions of the two color populations are distinct to a high confidence level (>95%) and fit them individually to a broken power law, with special attention given to evaluating and correcting for incompleteness in the Trojan catalog as well as incompleteness in our categorization of objects. A comparison of the best-fit curves shows that the faint-end power-law slopes are markedly different for the two color populations, which indicates that the red and less red Trojans likely formed in different locations. We propose a few hypotheses for the origin and evolution of the Trojan population based on the analyzed data.

  9. Vortex nozzle for segmenting and transporting metal chips from turning operations

    DOE Patents [OSTI]

    Bieg, L.F.

    1993-04-20

    Apparatus for collecting, segmenting and conveying metal chips from machining operations utilizes a compressed gas driven vortex nozzle for receiving the chip and twisting it to cause the chip to segment through the application of torsional forces to the chip. The vortex nozzle is open ended and generally tubular in shape with a converging inlet end, a constant diameter throat section and a diverging exhaust end. Compressed gas is discharged through angled vortex ports in the nozzle throat section to create vortex flow in the nozzle and through an annular inlet at the entrance to the converging inlet end to create suction at the nozzle inlet and cause ambient air to enter the nozzle. The vortex flow in the nozzle causes the metal chip to segment and the segments thus formed to pass out of the discharge end of the nozzle where they are collected, cleaned and compacted as needed.

  10. Image feature based GPS trace filtering for road network generation and road segmentation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yuan, Jiangye; Cheriyadat, Anil M.

    2015-10-19

    We propose a new method to infer road networks from GPS trace data and accurately segment road regions in high-resolution aerial images. Unlike previous efforts that rely on GPS traces alone, we exploit image features to infer road networks from noisy trace data. The inferred road network is used to guide road segmentation. We show that the number of image segments spanned by the traces and the trace orientation validated with image features are important attributes for identifying GPS traces on road regions. Based on filtered traces , we construct road networks and integrate them with image features to segmentmore » road regions. Lastly, our experiments show that the proposed method produces more accurate road networks than the leading method that uses GPS traces alone, and also achieves high accuracy in segmenting road regions even with very noisy GPS data.« less

  11. DISTINCT CHEMICAL REGIONS IN THE ''PRESTELLAR'' INFRARED DARK CLOUD G028.23-00.19

    SciTech Connect (OSTI)

    Sanhueza, Patricio; Jackson, James M. [Institute for Astrophysical Research, Boston University, Boston, MA 02215 (United States); Foster, Jonathan B. [Yale Center for Astronomy and Astrophysics, Yale University, New Haven, CT 06520 (United States); Jimenez-Serra, Izaskun [European Southern Observatory, Karl-Schwarzschild-Str. 2, D-85748 Garching (Germany); Dirienzo, William J. [Department of Astronomy, University of Virginia, P.O. Box 3818, Charlottesville, VA 22903 (United States); Pillai, Thushara, E-mail: patricio@bu.edu [Caltech, MC 249-17, 1200 East California Boulevard, Pasadena, CA 91125 (United States)

    2013-08-20

    We have observed the Infrared Dark Cloud (IRDC) G028.23-00.19 at 3.3 mm using the Combined Array for Research in Millimeter-wave Astronomy. In its center, the IRDC hosts one of the most massive ({approx}1520 M{sub Sun }) quiescent, cold (12 K) clumps known (MM1). The low temperature, high NH{sub 2}D abundance, narrow molecular line widths, and absence of embedded infrared sources (from 3.6 to 70 {mu}m) indicate that the clump is likely prestellar. Strong SiO emission with broad line widths (6-9 km s{sup -1}) and high abundances ((0.8-4) Multiplication-Sign 10{sup -9}) is detected in the northern and southern regions of the IRDC, unassociated with MM1. We suggest that SiO is released to the gas phase from the dust grains through shocks produced by outflows from undetected intermediate-mass stars or clusters of low-mass stars deeply embedded in the IRDC. A weaker SiO component with narrow line widths ({approx}2 km s{sup -1}) and low abundances (4.3 Multiplication-Sign 10{sup -11}) is detected in the center-west region, consistent with either a ''subcloud-subcloud'' collision or an unresolved population of a few low-mass stars. We report widespread CH{sub 3}OH emission throughout the whole IRDC and the first detection of extended narrow methanol emission ({approx}2 km s{sup -1}) in a cold, massive prestellar clump (MM1). We suggest that the most likely mechanism releasing methanol into the gas phase in such a cold region is the exothermicity of grain-surface reactions. HN{sup 13}C reveals that the IRDC is actually composed of two distinct substructures ({sup s}ubclouds{sup )} separated in velocity space by {approx}1.4 km s{sup -1}. The narrow SiO component arises where the subclouds overlap. The spatial distribution of C{sub 2}H resembles that of NH{sub 2}D, which suggests that C{sub 2}H also traces cold gas in this IRDC.

  12. Energy demand and population changes

    SciTech Connect (OSTI)

    Allen, E.L.; Edmonds, J.A.

    1980-12-01

    Since World War II, US energy demand has grown more rapidly than population, so that per capita consumption of energy was about 60% higher in 1978 than in 1947. Population growth and the expansion of per capita real incomes have led to a greater use of energy. The aging of the US population is expected to increase per capita energy consumption, despite the increase in the proportion of persons over 65, who consume less energy than employed persons. The sharp decline in the population under 18 has led to an expansion in the relative proportion of population in the prime-labor-force age groups. Employed persons are heavy users of energy. The growth of the work force and GNP is largely attributable to the growing participation of females. Another important consequence of female employment is the growth in ownership of personal automobiles. A third factor pushing up labor-force growth is the steady influx of illegal aliens.

  13. Interactive prostate segmentation using atlas-guided semi-supervised learning and adaptive feature selection

    SciTech Connect (OSTI)

    Park, Sang Hyun; Gao, Yaozong; Shi, Yinghuan; Shen, Dinggang

    2014-11-01

    Purpose: Accurate prostate segmentation is necessary for maximizing the effectiveness of radiation therapy of prostate cancer. However, manual segmentation from 3D CT images is very time-consuming and often causes large intra- and interobserver variations across clinicians. Many segmentation methods have been proposed to automate this labor-intensive process, but tedious manual editing is still required due to the limited performance. In this paper, the authors propose a new interactive segmentation method that can (1) flexibly generate the editing result with a few scribbles or dots provided by a clinician, (2) fast deliver intermediate results to the clinician, and (3) sequentially correct the segmentations from any type of automatic or interactive segmentation methods. Methods: The authors formulate the editing problem as a semisupervised learning problem which can utilize a priori knowledge of training data and also the valuable information from user interactions. Specifically, from a region of interest near the given user interactions, the appropriate training labels, which are well matched with the user interactions, can be locally searched from a training set. With voting from the selected training labels, both confident prostate and background voxels, as well as unconfident voxels can be estimated. To reflect informative relationship between voxels, location-adaptive features are selected from the confident voxels by using regression forest and Fisher separation criterion. Then, the manifold configuration computed in the derived feature space is enforced into the semisupervised learning algorithm. The labels of unconfident voxels are then predicted by regularizing semisupervised learning algorithm. Results: The proposed interactive segmentation method was applied to correct automatic segmentation results of 30 challenging CT images. The correction was conducted three times with different user interactions performed at different time periods, in order to

  14. TWO POPULATIONS OF GAMMA-RAY BURST RADIO AFTERGLOWS

    SciTech Connect (OSTI)

    Hancock, P. J.; Gaensler, B. M.; Murphy, T., E-mail: Paul.Hancock@Sydney.edu.au [Also at Australian Research Council Centre of Excellence for All-sky Astrophysics (CAASTRO), The University of Sydney, Sydney, NSW 2006, Australia. (Australia)

    2013-10-20

    The detection rate of gamma-ray burst (GRB) afterglows is ?30% at radio wavelengths, much lower than in the X-ray (?95%) or optical (?70%) bands. The cause of this low radio detection rate has previously been attributed to limited observing sensitivity. We use visibility stacking to test this idea, and conclude that the low detection rate is instead due to two intrinsically different populations of GRBs: radio-bright and radio-faint. We calculate that no more than 70% of GRB afterglows are truly radio-bright, leaving a significant population of GRBs that lack a radio afterglow. These radio-bright GRBs have higher gamma-ray fluence, isotropic energies, X-ray fluxes, and optical fluxes than the radio-faint GRBs, thus confirming the existence of two physically distinct populations. We suggest that the gamma-ray efficiency of the prompt emission is responsible for the difference between the two populations. We also discuss the implications for future radio and optical surveys.

  15. Application of Micro-segmentation Algorithms to the Healthcare Market:A Case Study

    SciTech Connect (OSTI)

    Sukumar, Sreenivas R; Aline, Frank

    2013-01-01

    We draw inspiration from the recent success of loyalty programs and targeted personalized market campaigns of retail companies such as Kroger, Netflix, etc. to understand beneficiary behaviors in the healthcare system. Our posit is that we can emulate the financial success the companies have achieved by better understanding and predicting customer behaviors and translating such success to healthcare operations. Towards that goal, we survey current practices in market micro-segmentation research and analyze health insurance claims data using those algorithms. We present results and insights from micro-segmentation of the beneficiaries using different techniques and discuss how the interpretation can assist with matching the cost-effective insurance payment models to the beneficiary micro-segments.

  16. A Segmented, Enriched N-type Germanium Detector for Neutrinoless Double Beta-Decay Experiments

    SciTech Connect (OSTI)

    Leviner, L.; Aalseth, Craig E.; Ahmed, M. W.; Avignone, F. T.; Back, Henning O.; Barabash, Alexander S.; Boswell, M.; De Braeckeleer, L.; Brudanin, V.; Chan, Yuen-Dat; Egorov, Viatcheslav; Elliott, Steven R.; Gehman, Victor M.; Hossbach, Todd W.; Kephart, Jeremy; Kidd, M. F.; Konovalov, S.; Lesko, Kevin; Li, Jingyi; Mei, Dongming; Mikhailov, S.; Miley, Harry S.; Radford, D. C.; Reeves, James H.; Sandukovsky, Viatcheslav; Umatov, Valdimir; Underwood, T. A.; Tornow, W.; Wu, Y. K.; Young, A.

    2014-01-21

    We present data characterizing the performance of the _rst segmented, N- type Ge detector, isotopically enriched to 85% 76Ge. This detector, based on the Ortec PT6x2 design and referred to as SEGA (Segmented, Enriched Germanium Assembly), was developed as a possible prototype for neutrinoless double beta-decay measurements by the Majorana collaboration. We present some of the general characteristics (including bias potential, efficiency, leakage current, and integral cross-talk) for this detector in its temporary cryostat. We also present an analysis of the resolution of the detector, and demonstrate that for all but two segments there is at least one channel that reaches the Majorana resolution goal below 4 keV FWHM at 2039 keV, and all channels are below 4.5 keV FWHM.

  17. Two distinct origins of a common BRCA1 mutation in breast-ovarian cancer families: A genetic study of 15 185delAG-mutation kindreds

    SciTech Connect (OSTI)

    Berman, D.B.; Schultz, D.C.; Godwin, A.K.

    1996-06-01

    We screened 163 women from breast-ovarian cancer-prone families, as well as 178 individuals affected with breast and/or ovarian cancer but unselected for family history, for germ-line mutations in exon 2 of BRCA1, by SSCP analysis and direct sequencing. A total of 25 mutations were detected. Thirteen of 64 Jewish Ashkenazi women and 2 non-Jewish individuals were found to possess the 185delAG mutation. Haplotype data for all 15 individuals, with markers intragenic to BRCA1, suggest that the Jewish Ashkenazi individuals share a common ancestry that is distinct from the lineage shared by the other two women. These data provide the first evidence of two distinct lines of transmission for the 185delAG mutation, only one of which has its origins in the Jewish Ashkenazi population. Our screening also uncovered 10 affected individuals with an 11-bp deletion at nucleotide 188 of BRCA1 (188del11), 4 of whom are Ashkenazi Jews. This is only the third reported mutation detected within the Jewish Ashkenazi population and may represent the second most common alteration in BRCA1 found in Ashkenazi Jews in the United States. The observed overrepresentation of specific mutations within a subgroup of the general population may eventually contribute to the development of inexpensive and routine tests for BRCA1 mutations, as well as to the elucidation of other contributory factors (e.g., diet, environment, and chemical exposures) that may play a key role in cancer initiation and development. The implications of the mutational data, as well as the role that founder effect, demographic history, and penetrance play in the resulting observed phenomena, are discussed. 32 refs., 3 figs., 2 tabs.

  18. Using Doppler spectra to separate hydrometeor populations and analyze ice precipitation in multilayered mixed-phase clouds

    SciTech Connect (OSTI)

    Rambukkange, Mahlon P.; Verlinde, J.; Eloranta, E. W.; Flynn, Connor J.; Clothiaux, Eugene E.

    2011-01-31

    Multimodality of cloud radar Doppler spectra is used to partition cloud particle phases and to separate distinct ice populations in the radar sample volume, thereby facilitating analysis of individual ice showers in multilayered mixed-phase clouds. A 35-GHz cloud radar located at Barrow, Alaska, during the Mixed-Phase Arctic Cloud Experiment collected the Doppler spectra. Data from a pair of collocated depolarization lidars confirmed the presence of two liquid cloud layers reported in this study. Surprisingly, both of these cloud layers were embedded in ice precipitation yet maintained their liquid. Our spectral separation of the ice precipitation yielded two distinct ice populations: ice initiated within the two liquid cloud layers and ice precipitation formed in higher cloud layers. Comparisons of ice fall velocity versus radar reflectivity relationships derived for distinct showers reveal that a single relationship might not properly represent the ice showers during this period.

  19. Segmented superconducting tape having reduced AC losses and method of making

    DOE Patents [OSTI]

    Foltyn, Stephen R.; Jia, Quanxi; Arendt, Paul N.; Holesinger, Terry G.; Wang, Haiyan

    2009-09-22

    A superconducting tape having reduced AC losses. The tape has a high temperature superconductor layer that is segmented. Disruptive strips, formed in one of the tape substrate, a buffer layer, and the superconducting layer create parallel discontinuities in the superconducting layer that separate the current-carrying elements of the superconducting layer into strips or filament-like structures. Segmentation of the current-carrying elements has the effect of reducing AC current losses. Methods of making such a superconducting tape and reducing AC losses in such tapes are also disclosed.

  20. Comparison of Daytime and Nighttime Populations Adjacent to Interstate Highways in Metropolitan Areas Using LandScan USA

    SciTech Connect (OSTI)

    Johnson, Paul E

    2007-01-01

    An article of similar title was published in the International Journal of Radioactive Materials Transport in 1999. The study concluded that the daytime and nighttime populations are not substantially different for the metropolitan areas examined. This study revisits the issue, but using the LandScan USA high resolution population distribution data, which includes daytime and night-time population. Segments of Interstate highway beltways, along with the direct route through the city, for Atlanta, St. Louis, and Kansas City are examined with an 800m buffer from either side of the highways. The day/night ratio of population is higher using the LandScan USA data. LandScan USA daytime and night-time data will be incorporated into the TRAGIS routing model in future.

  1. Chemical constraints on the contribution of population III stars to cosmic reionization

    SciTech Connect (OSTI)

    Kulkarni, Girish; Hennawi, Joseph F. [Max Planck Institute for Astronomy, Knigstuhl 17, D-69117 Heidelberg (Germany); Rollinde, Emmanuel; Vangioni, Elisabeth, E-mail: girish@mpia-hd.mpg.de [Institut d'Astrophysique de Paris, UMR 7095, UPMC, Paris VI, 98 bis boulevard Arago, F-75014 Paris (France)

    2014-05-20

    Recent studies have highlighted that galaxies at z = 6-8 fall short of producing enough ionizing photons to reionize the intergalactic medium, and suggest that Population III stars could resolve this tension, because their harder spectra can produce ?10 more ionizing photons than Population II. We use a semi-analytic model of galaxy formation, which tracks galactic chemical evolution, to gauge the impact of Population III stars on reionization. Population III supernovae produce distinct metal abundances, and we argue that the duration of the Population III era can be constrained by precise relative abundance measurements in high-z damped Ly? absorbers (DLAs), which provide a chemical record of past star formation. We find that a single generation of Population III stars can self-enrich galaxies above the critical metallicity Z {sub crit} = 10{sup 4} Z {sub ?} for the Population III-to-II transition, on a very short timescale t {sub self-enrich} ? 10{sup 6} yr, owing to the large metal yields and short lifetimes of Population III stars. This subsequently terminates the Population III era, so they contribute ? 50% of the ionizing photons only for z ? 30, and at z = 10 contribute <1%. The Population III contribution can be increased by delaying metal mixing into the interstellar medium. However, comparing the resulting metal abundance pattern to existing measurements in z ? 6 DLAs, we show that the observed [O/Si] ratios of absorbers rule out Population III stars being a major contributor to reionization. Future abundance measurements of z ? 7-8 QSOs and gamma-ray bursts should probe the era when the chemical vestiges of Population III star formation become detectable.

  2. Toward accurate tooth segmentation from computed tomography images using a hybrid level set model

    SciTech Connect (OSTI)

    Gan, Yangzhou; Zhao, Qunfei; Xia, Zeyang E-mail: jing.xiong@siat.ac.cn; Hu, Ying; Xiong, Jing E-mail: jing.xiong@siat.ac.cn; Zhang, Jianwei

    2015-01-15

    Purpose: A three-dimensional (3D) model of the teeth provides important information for orthodontic diagnosis and treatment planning. Tooth segmentation is an essential step in generating the 3D digital model from computed tomography (CT) images. The aim of this study is to develop an accurate and efficient tooth segmentation method from CT images. Methods: The 3D dental CT volumetric images are segmented slice by slice in a two-dimensional (2D) transverse plane. The 2D segmentation is composed of a manual initialization step and an automatic slice by slice segmentation step. In the manual initialization step, the user manually picks a starting slice and selects a seed point for each tooth in this slice. In the automatic slice segmentation step, a developed hybrid level set model is applied to segment tooth contours from each slice. Tooth contour propagation strategy is employed to initialize the level set function automatically. Cone beam CT (CBCT) images of two subjects were used to tune the parameters. Images of 16 additional subjects were used to validate the performance of the method. Volume overlap metrics and surface distance metrics were adopted to assess the segmentation accuracy quantitatively. The volume overlap metrics were volume difference (VD, mm{sup 3}) and Dice similarity coefficient (DSC, %). The surface distance metrics were average symmetric surface distance (ASSD, mm), RMS (root mean square) symmetric surface distance (RMSSSD, mm), and maximum symmetric surface distance (MSSD, mm). Computation time was recorded to assess the efficiency. The performance of the proposed method has been compared with two state-of-the-art methods. Results: For the tested CBCT images, the VD, DSC, ASSD, RMSSSD, and MSSD for the incisor were 38.16 ± 12.94 mm{sup 3}, 88.82 ± 2.14%, 0.29 ± 0.03 mm, 0.32 ± 0.08 mm, and 1.25 ± 0.58 mm, respectively; the VD, DSC, ASSD, RMSSSD, and MSSD for the canine were 49.12 ± 9.33 mm{sup 3}, 91.57 ± 0.82%, 0.27 ± 0.02 mm, 0

  3. Reactor Vessel and Reactor Vessel Internals Segmentation at Zion Nuclear Power Station - 13230

    SciTech Connect (OSTI)

    Cooke, Conrad; Spann, Holger

    2013-07-01

    Zion Nuclear Power Station (ZNPS) is a dual-unit Pressurized Water Reactor (PWR) nuclear power plant located on the Lake Michigan shoreline, in the city of Zion, Illinois approximately 64 km (40 miles) north of Chicago, Illinois and 67 km (42 miles) south of Milwaukee, Wisconsin. Each PWR is of the Westinghouse design and had a generation capacity of 1040 MW. Exelon Corporation operated both reactors with the first unit starting production of power in 1973 and the second unit coming on line in 1974. The operation of both reactors ceased in 1996/1997. In 2010 the Nuclear Regulatory Commission approved the transfer of Exelon Corporation's license to ZionSolutions, the Long Term Stewardship subsidiary of EnergySolutions responsible for the decommissioning of ZNPS. In October 2010, ZionSolutions awarded Siempelkamp Nuclear Services, Inc. (SNS) the contract to plan, segment, remove, and package both reactor vessels and their respective internals. This presentation discusses the tools employed by SNS to remove and segment the Reactor Vessel Internals (RVI) and Reactor Vessels (RV) and conveys the recent progress. SNS's mechanical segmentation tooling includes the C-HORCE (Circumferential Hydraulically Operated Cutting Equipment), BMT (Bolt Milling Tool), FaST (Former Attachment Severing Tool) and the VRS (Volume Reduction Station). Thermal segmentation of the reactor vessels will be accomplished using an Oxygen- Propane cutting system. The tools for internals segmentation were designed by SNS using their experience from other successful reactor and large component decommissioning and demolition (D and D) projects in the US. All of the designs allow for the mechanical segmentation of the internals remotely in the water-filled reactor cavities. The C-HORCE is designed to saw seven circumferential cuts through the Core Barrel and Thermal Shield walls with individual thicknesses up to 100 mm (4 inches). The BMT is designed to remove the bolts that fasten the Baffle Plates to

  4. Multilevel learning-based segmentation of ill-defined and spiculated masses in mammograms

    SciTech Connect (OSTI)

    Tao, Yimo; Lo, Shih-Chung B.; Freedman, Matthew T.; Makariou, Erini; Xuan, Jianhua

    2010-11-15

    Purpose: A learning-based approach integrating the use of pixel-level statistical modeling and spiculation detection is presented for the segmentation of mammographic masses with ill-defined margins and spiculations. Methods: The algorithm involves a multiphase pixel-level classification, using a comprehensive group of features computed from regional intensity, shape, and textures, to generate a mass-conditional probability map (PM). Then, the mass candidate, along with the background clutters consisting of breast fibroglandular and other nonmass tissues, is extracted from the PM by integrating the prior knowledge of shape and location of masses. A multiscale steerable ridge detection algorithm is employed to detect spiculations. Finally, all the object-level findings, including mass candidate, detected spiculations, and clutters, along with the PM, are integrated by graph cuts to generate the final segmentation mask. Results: The method was tested on 54 masses (51 malignant and 3 benign), all with ill-defined margins and irregular shape or spiculations. The ground truth delineations were provided by five experienced radiologists. Area overlapping ratio of 0.689 ({+-}0.160) and 0.540 ({+-}0.164) were obtained for segmenting entire mass and margin portion only, respectively. Williams index of area and contour based measurements indicated that the segmentation results of the algorithm agreed well with the radiologists' delineation. Conclusions: The proposed approach could closely delineate the mass body. Most importantly, it is capable of including mass margin and its spicule extensions which are considered as key features for breast lesion analyses.

  5. Two-stage atlas subset selection in multi-atlas based image segmentation

    SciTech Connect (OSTI)

    Zhao, Tingting Ruan, Dan

    2015-06-15

    Purpose: Fast growing access to large databases and cloud stored data presents a unique opportunity for multi-atlas based image segmentation and also presents challenges in heterogeneous atlas quality and computation burden. This work aims to develop a novel two-stage method tailored to the special needs in the face of large atlas collection with varied quality, so that high-accuracy segmentation can be achieved with low computational cost. Methods: An atlas subset selection scheme is proposed to substitute a significant portion of the computationally expensive full-fledged registration in the conventional scheme with a low-cost alternative. More specifically, the authors introduce a two-stage atlas subset selection method. In the first stage, an augmented subset is obtained based on a low-cost registration configuration and a preliminary relevance metric; in the second stage, the subset is further narrowed down to a fusion set of desired size, based on full-fledged registration and a refined relevance metric. An inference model is developed to characterize the relationship between the preliminary and refined relevance metrics, and a proper augmented subset size is derived to ensure that the desired atlases survive the preliminary selection with high probability. Results: The performance of the proposed scheme has been assessed with cross validation based on two clinical datasets consisting of manually segmented prostate and brain magnetic resonance images, respectively. The proposed scheme demonstrates comparable end-to-end segmentation performance as the conventional single-stage selection method, but with significant computation reduction. Compared with the alternative computation reduction method, their scheme improves the mean and medium Dice similarity coefficient value from (0.74, 0.78) to (0.83, 0.85) and from (0.82, 0.84) to (0.95, 0.95) for prostate and corpus callosum segmentation, respectively, with statistical significance. Conclusions: The authors

  6. Brachial artery vasomotion and transducer pressure effect on measurements by active contour segmentation on ultrasound

    SciTech Connect (OSTI)

    Cary, Theodore W.; Sultan, Laith R.; Sehgal, Chandra M.; Reamer, Courtney B.; Mohler, Emile R.

    2014-02-15

    Purpose: To use feed-forward active contours (snakes) to track and measure brachial artery vasomotion on ultrasound images recorded in both transverse and longitudinal views; and to compare the algorithm's performance in each view. Methods: Longitudinal and transverse view ultrasound image sequences of 45 brachial arteries were segmented by feed-forward active contour (FFAC). The segmented regions were used to measure vasomotion artery diameter, cross-sectional area, and distention both as peak-to-peak diameter and as area. ECG waveforms were also simultaneously extracted frame-by-frame by thresholding a running finite-difference image between consecutive images. The arterial and ECG waveforms were compared as they traced each phase of the cardiac cycle. Results: FFAC successfully segmented arteries in longitudinal and transverse views in all 45 cases. The automated analysis took significantly less time than manual tracing, but produced superior, well-behaved arterial waveforms. Automated arterial measurements also had lower interobserver variability as measured by correlation, difference in mean values, and coefficient of variation. Although FFAC successfully segmented both the longitudinal and transverse images, transverse measurements were less variable. The cross-sectional area computed from the longitudinal images was 27% lower than the area measured from transverse images, possibly due to the compression of the artery along the image depth by transducer pressure. Conclusions: FFAC is a robust and sensitive vasomotion segmentation algorithm in both transverse and longitudinal views. Transverse imaging may offer advantages over longitudinal imaging: transverse measurements are more consistent, possibly because the method is less sensitive to variations in transducer pressure during imaging.

  7. Steam Dryer Segmentation and Packaging at Grand Gulf Nuclear Station - 13577

    SciTech Connect (OSTI)

    Kreitman, Paul J.; Sirianni, Steve R.; Pillard, Mark M.

    2013-07-01

    Entergy recently performed an Extended Power Up-rate (EPU) on their Grand Gulf Nuclear Station, near Port Gibson, Mississippi. To support the EPU, a new Steam Dryer Assembly was installed during the last refueling outage. Due to limited access into the containment, the large Replacement Steam Dryer (RSD) had to be brought into the containment in pieces and then final assembly was completed on the refueling floor before installation into the reactor. Likewise, the highly contaminated Original Steam Dryer (OSD) had to be segmented into manageable sections, loaded into specially designed shielded containers, and rigged out of containment where they will be safely stored until final disposal is accomplished at an acceptable waste repository. Westinghouse Nuclear Services was contracted by Entergy to segment, package and remove the OSD from containment. This work was performed on critical path during the most recent refueling outage. The segmentation was performed underwater to minimize radiation exposure to the workers. Special hydraulic saws were developed for the cutting operations based on Westinghouse designs previously used in Sweden to segment ABB Reactor Internals. The mechanical cutting method was selected because of its proven reliability and the minimal cutting debris that is generated by the process. Maintaining stability of the large OSD sections during cutting was accomplished using a custom built support stand that was installed into the Moisture Separator Pool after the Moisture Separator was installed back in the reactor vessel. The OSD was then moved from the Steam Dryer Pool to the Moisture Separator Pool for segmentation. This scenario resolved the logistical challenge of having two steam dryers and a moisture separator in containment simultaneously. A water filtration/vacuum unit was supplied to maintain water clarity during the cutting and handling operations and to collect the cutting chips. (authors)

  8. Evaluation of Automatic Atlas-Based Lymph Node Segmentation for Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Stapleford, Liza J.; Lawson, Joshua D.; Perkins, Charles; Edelman, Scott; Davis, Lawrence

    2010-07-01

    Purpose: To evaluate if automatic atlas-based lymph node segmentation (LNS) improves efficiency and decreases inter-observer variability while maintaining accuracy. Methods and Materials: Five physicians with head-and-neck IMRT experience used computed tomography (CT) data from 5 patients to create bilateral neck clinical target volumes covering specified nodal levels. A second contour set was automatically generated using a commercially available atlas. Physicians modified the automatic contours to make them acceptable for treatment planning. To assess contour variability, the Simultaneous Truth and Performance Level Estimation (STAPLE) algorithm was used to take collections of contours and calculate a probabilistic estimate of the 'true' segmentation. Differences between the manual, automatic, and automatic-modified (AM) contours were analyzed using multiple metrics. Results: Compared with the 'true' segmentation created from manual contours, the automatic contours had a high degree of accuracy, with sensitivity, Dice similarity coefficient, and mean/max surface disagreement values comparable to the average manual contour (86%, 76%, 3.3/17.4 mm automatic vs. 73%, 79%, 2.8/17 mm manual). The AM group was more consistent than the manual group for multiple metrics, most notably reducing the range of contour volume (106-430 mL manual vs. 176-347 mL AM) and percent false positivity (1-37% manual vs. 1-7% AM). Average contouring time savings with the automatic segmentation was 11.5 min per patient, a 35% reduction. Conclusions: Using the STAPLE algorithm to generate 'true' contours from multiple physician contours, we demonstrated that, in comparison with manual segmentation, atlas-based automatic LNS for head-and-neck cancer is accurate, efficient, and reduces interobserver variability.

  9. Distinct p53 genomic binding patterns in normal and cancer-derived human cells

    SciTech Connect (OSTI)

    Botcheva K.; McCorkle S. R.; McCombie W. R.; Dunn J. J.; Anderson C. W.

    2011-12-15

    We report here genome-wide analysis of the tumor suppressor p53 binding sites in normal human cells. 743 high-confidence ChIP-seq peaks representing putative genomic binding sites were identified in normal IMR90 fibroblasts using a reference chromatin sample. More than 40% were located within 2 kb of a transcription start site (TSS), a distribution similar to that documented for individually studied, functional p53 binding sites and, to date, not observed by previous p53 genome-wide studies. Nearly half of the high-confidence binding sites in the IMR90 cells reside in CpG islands, in marked contrast to sites reported in cancer-derived cells. The distinct genomic features of the IMR90 binding sites do not reflect a distinct preference for specific sequences, since the de novo developed p53 motif based on our study is similar to those reported by genome-wide studies of cancer cells. More likely, the different chromatin landscape in normal, compared with cancer-derived cells, influences p53 binding via modulating availability of the sites. We compared the IMR90 ChIPseq peaks to the recently published IMR90 methylome1 and demonstrated that they are enriched at hypomethylated DNA. Our study represents the first genome-wide, de novo mapping of p53 binding sites in normal human cells and reveals that p53 binding sites reside in distinct genomic landscapes in normal and cancer-derived human cells.

  10. Comparative analysis of nonlinear dimensionality reduction techniques for breast MRI segmentation

    SciTech Connect (OSTI)

    Akhbardeh, Alireza; Jacobs, Michael A.

    2012-04-15

    Purpose: Visualization of anatomical structures using radiological imaging methods is an important tool in medicine to differentiate normal from pathological tissue and can generate large amounts of data for a radiologist to read. Integrating these large data sets is difficult and time-consuming. A new approach uses both supervised and unsupervised advanced machine learning techniques to visualize and segment radiological data. This study describes the application of a novel hybrid scheme, based on combining wavelet transform and nonlinear dimensionality reduction (NLDR) methods, to breast magnetic resonance imaging (MRI) data using three well-established NLDR techniques, namely, ISOMAP, local linear embedding (LLE), and diffusion maps (DfM), to perform a comparative performance analysis. Methods: Twenty-five breast lesion subjects were scanned using a 3T scanner. MRI sequences used were T1-weighted, T2-weighted, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging. The hybrid scheme consisted of two steps: preprocessing and postprocessing of the data. The preprocessing step was applied for B{sub 1} inhomogeneity correction, image registration, and wavelet-based image compression to match and denoise the data. In the postprocessing step, MRI parameters were considered data dimensions and the NLDR-based hybrid approach was applied to integrate the MRI parameters into a single image, termed the embedded image. This was achieved by mapping all pixel intensities from the higher dimension to a lower dimensional (embedded) space. For validation, the authors compared the hybrid NLDR with linear methods of principal component analysis (PCA) and multidimensional scaling (MDS) using synthetic data. For the clinical application, the authors used breast MRI data, comparison was performed using the postcontrast DCE MRI image and evaluating the congruence of the segmented lesions. Results: The NLDR-based hybrid approach was able to define and segment

  11. Tracking fuzzy borders using geodesic curves with application to liver segmentation on planning CT

    SciTech Connect (OSTI)

    Yuan, Yading Chao, Ming; Sheu, Ren-Dih; Rosenzweig, Kenneth; Lo, Yeh-Chi

    2015-07-15

    Purpose: This work aims to develop a robust and efficient method to track the fuzzy borders between liver and the abutted organs where automatic liver segmentation usually suffers, and to investigate its applications in automatic liver segmentation on noncontrast-enhanced planning computed tomography (CT) images. Methods: In order to track the fuzzy liver–chestwall and liver–heart borders where oversegmentation is often found, a starting point and an ending point were first identified on the coronal view images; the fuzzy border was then determined as a geodesic curve constructed by minimizing the gradient-weighted path length between these two points near the fuzzy border. The minimization of path length was numerically solved by fast-marching method. The resultant fuzzy borders were incorporated into the authors’ automatic segmentation scheme, in which the liver was initially estimated by a patient-specific adaptive thresholding and then refined by a geodesic active contour model. By using planning CT images of 15 liver patients treated with stereotactic body radiation therapy, the liver contours extracted by the proposed computerized scheme were compared with those manually delineated by a radiation oncologist. Results: The proposed automatic liver segmentation method yielded an average Dice similarity coefficient of 0.930 ± 0.015, whereas it was 0.912 ± 0.020 if the fuzzy border tracking was not used. The application of fuzzy border tracking was found to significantly improve the segmentation performance. The mean liver volume obtained by the proposed method was 1727 cm{sup 3}, whereas it was 1719 cm{sup 3} for manual-outlined volumes. The computer-generated liver volumes achieved excellent agreement with manual-outlined volumes with correlation coefficient of 0.98. Conclusions: The proposed method was shown to provide accurate segmentation for liver in the planning CT images where contrast agent is not applied. The authors’ results also clearly

  12. Genetic Structure of Chum Salmon (Oncorhynchus Keta) Populations in the Lower Columbia River: Are Chum Salmon in Cascade Tributaries Remnant Populations?

    SciTech Connect (OSTI)

    Small, Maureen P.; Pichahchy, A.E.; Von Bargen, J.F.; Young, S.F.

    2004-09-01

    Prior to the 1950's, the lower Columbia River drainage supported a run of over a million chum salmon composed of at least 16 populations. By the late 1950's, over-fishing and habitat destruction had decreased the run to as little as a few hundred fish. With the exception of Grays River in the coastal region of the Columbia River and an aggregation of chum salmon spawning in creeks and the mainstem near Bonneville Dam in the Columbia Gorge region, most populations were considered extinct. However, over the years, WDFW biologists detected chum salmon spawning in tributaries originating in the Cascade Range: the Cowlitz, Lewis, and Washougal rivers. Further, chum salmon in the Cowlitz River appeared to have summer and fall run-timings. To assess whether Cascade spawners were strays from Grays River and Gorge regions or remnants of former populations, chum salmon from the Coastal, Cascade and Gorge regions were characterized genetically at 17 microsatellite loci. With the exception of Washougal River chum salmon, which grouped strongly with the Gorge genetic group, significant heterogeneity in genotype distributions were detected between regions and genotype distributions overlapped among collections within regions. In a neighbor-joining consensus tree, regional groups occupied branches with over 77% bootstrap support. In assignment tests, over 63% of individuals were correctly assigned back to region of origin although an average of 29% assigned to river of origin. Genetic distinction of Cascade region chum salmon was similar to distinction of Coastal and Gorge chum salmon and the Cascade region chum salmon had twice the number of private regional alleles. Further, the Cowlitz River supports the only summer chum salmon run in the Columbia River drainage. We propose that chum salmon in the Cascade region are remnants of original populations. We attribute the strong divergence between regional groups to diverse ecological conditions in each region, which promoted

  13. Support pedestals for interconnecting a cover and nozzle band wall in a gas turbine nozzle segment

    DOE Patents [OSTI]

    Yu, Yufeng Phillip; Itzel, Gary Michael; Webbon, Waylon Willard; Bagepalli, Radhakrishna; Burdgick, Steven Sebastian; Kellock, Iain Robertson

    2002-01-01

    A gas turbine nozzle segment has outer and inner band portions. Each band portion includes a nozzle wall, a cover and an impingement plate between the cover and nozzle wall defining two cavities on opposite sides of the impingement plate. Cooling steam is supplied to one cavity for flow through the apertures of the impingement plate to cool the nozzle wall. Structural pedestals interconnect the cover and nozzle wall and pass through holes in the impingement plate to reduce localized stress otherwise resulting from a difference in pressure within the chamber of the nozzle segment and the hot gas path and the fixed turbine casing surrounding the nozzle stage. The pedestals may be cast or welded to the cover and nozzle wall.

  14. Apparatus and methods for impingement cooling of a side wall of a turbine nozzle segment

    DOE Patents [OSTI]

    Burdgick, Steven Sebastian (Schenectady, NY)

    2002-01-01

    A gas turbine nozzle segment has outer and inner bands and a vane therebetween. Each band includes a nozzle wall, a side wall, a cover and an impingement plate between the cover and the nozzle wall defining two cavities on opposite sides of the impingement plate. Cooling steam is supplied to one cavity for flow through apertures of the impingement plate to cool the nozzle wall. The side wall of the band and inturned flange define with the nozzle wall an undercut region. The impingement plate has a turned flange welded to the inturned flange. A backing plate overlies the turned flange and aligned apertures are formed through the backing plate and turned flange to direct and focus cooling flow onto the side wall of the nozzle segment.

  15. An Inverter Packaging Scheme for an Integrated Segmented Traction Drive System

    SciTech Connect (OSTI)

    Su, Gui-Jia; Tang, Lixin; Ayers, Curtis William; Wiles, Randy H

    2013-01-01

    The standard voltage source inverter (VSI), widely used in electric vehicle/hybrid electric vehicle (EV/HEV) traction drives, requires a bulky dc bus capacitor to absorb the large switching ripple currents and prevent them from shortening the battery s life. The dc bus capacitor presents a significant barrier to meeting inverter cost, volume, and weight requirements for mass production of affordable EVs/HEVs. The large ripple currents become even more problematic for the film capacitors (the capacitor technology of choice for EVs/HEVs) in high temperature environments as their ripple current handling capability decreases rapidly with rising temperatures. It is shown in previous work that segmenting the VSI based traction drive system can significantly decrease the ripple currents and thus the size of the dc bus capacitor. This paper presents an integrated packaging scheme to reduce the system cost of a segmented traction drive.

  16. Bias in segmented gamma scans arising from size differences between calibration standards and assay samples

    SciTech Connect (OSTI)

    Sampson, T.E. )

    1991-01-01

    Recent advances in segmented gamma scanning have emphasized software corrections for gamma-ray self-adsorption in particulates or lumps of special nuclear material in the sample. another feature of this software is an attenuation correction factor formalism that explicitly accounts for differences in sample container size and composition between the calibration standards and the individual items being measured. Software without this container-size correction produces biases when the unknowns are not packaged in the same containers as the calibration standards. This new software allows the use of different size and composition containers for standards and unknowns, as enormous savings considering the expense of multiple calibration standard sets otherwise needed. This paper presents calculations of the bias resulting from not using this new formalism. These calculations may be used to estimate bias corrections for segmented gamma scanners that do not incorporate these advanced concepts.

  17. Bleeding peptic ulcer caused by ectopic gastric mucosa in a duplicated segment of jejunum

    SciTech Connect (OSTI)

    Newmark, H.; Ching, G.; Halls, J.; Levy, I.J.

    1981-02-01

    The authors present a case in which a patient suffered a bleeding jejunal ulcer caused by heterotopic gastric mucosa in a congenital duplication of a segment of jejunum. This is the first case diagnosed preoperatively by two different radiographic means. These lesions were shown by both pertechnetate flow and barium small bowel studies. The rarity of these entities and the modalities used for diagnosis are described.

  18. Generator Bidding Strategies in a Competitive Electricity Market with Derating and Bid-Segment Considerations

    SciTech Connect (OSTI)

    Lu, Ning; Chow, Joe H.; Desrochers, Alan A.

    2009-07-31

    This paper develops optimal generator bidding strategies in a competitive electricity market. Starting from a generators cost curve, basic bidding concepts such as the break-even bid curve and the maximum profit bid curve can be readily derived. The maximum profit bid curve can be extended to account for generator availability and derating. In addition, multiple-segment block energy bids can be optimized based on the maximum profit curve and the probabilistic distribution of market clearing prices.

  19. Method of joining a vane cavity insert to a nozzle segment of a gas turbine

    DOE Patents [OSTI]

    Burdgick, Steven Sebastian (Schenectady, NY)

    2002-01-01

    An insert containing apertures for impingement cooling a nozzle vane of a nozzle segment in a gas turbine is inserted into one end of the vane. The leading end of the insert is positioned slightly past a rib adjacent the opposite end of the vane through which the insert is inserted. The end of the insert is formed or swaged into conformance with the inner margin of the rib. The insert is then brazed or welded to the rib.

  20. Simultaneous hierarchical segmentation and vectorization of satellite images through combined data sampling and anisotropic triangulation

    SciTech Connect (OSTI)

    Grazzini, Jacopo; Prasad, Lakshman; Dillard, Scott

    2010-10-21

    The automatic detection, recognition , and segmentation of object classes in remote sensed images is of crucial importance for scene interpretation and understanding. However, it is a difficult task because of the high variability of satellite data. Indeed, the observed scenes usually exhibit a high degree of complexity, where complexity refers to the large variety of pictorial representations of objects with the same semantic meaning and also to the extensive amount of available det.ails. Therefore, there is still a strong demand for robust techniques for automatic information extraction and interpretation of satellite images. In parallel, there is a growing interest in techniques that can extract vector features directly from such imagery. In this paper, we investigate the problem of automatic hierarchical segmentation and vectorization of multispectral satellite images. We propose a new algorithm composed of the following steps: (i) a non-uniform sampling scheme extracting most salient pixels in the image, (ii) an anisotropic triangulation constrained by the sampled pixels taking into account both strength and directionality of local structures present in the image, (iii) a polygonal grouping scheme merging, through techniques based on perceptual information , the obtained segments to a smaller quantity of superior vectorial objects. Besides its computational efficiency, this approach provides a meaningful polygonal representation for subsequent image analysis and/or interpretation.

  1. Image segmentation of nanoscale Zernike phase contrast X-ray computed tomography images

    SciTech Connect (OSTI)

    Kumar, Arjun S.; Mandal, Pratiti; Zhang, Yongjie; Litster, Shawn

    2015-05-14

    Zernike phase contrast is a useful technique for nanoscale X-ray computed tomography (CT) imaging of materials with a low X-ray absorption coefficient. It enhances the image contrast by phase shifting X-ray waves to create changes in amplitude. However, it creates artifacts that hinder the use of traditional image segmentation techniques. We propose an image restoration method that models the X-ray phase contrast optics and the three-dimensional image reconstruction method. We generate artifact-free images through an optimization problem that inverts this model. Though similar approaches have been used for Zernike phase contrast in visible light microscopy, this optimization employs an effective edge detection method tailored to handle Zernike phase contrast artifacts. We characterize this optics-based restoration method by removing the artifacts in and thresholding multiple Zernike phase contrast X-ray CT images to produce segmented results that are consistent with the physical specimens. We quantitatively evaluate and compare our method to other segmentation techniques to demonstrate its high accuracy.

  2. BETR North America: A regionally segmented multimedia contaminant fate model for North America

    SciTech Connect (OSTI)

    MacLeod, M.; Woodfine, D.G.; Mackay, D.; McKone, T.E.; Bennett, D.H.; Maddalena, R.L.

    2001-03-01

    We present the Berkeley-Trent North American contaminant fate model (BETR North America), a regionally segmented multimedia contaminant fate model based on the fugacity concept. The model is built on a framework that links contaminant fate models of individual regions, and is generally applicable to large, spatially heterogeneous areas. The North American environment is modeled as 24 ecological regions, within each region contaminant fate is described using a 7 compartment multimedia fugacity model including a vertically segmented atmosphere, freshwater, freshwater sediment, soil, coastal water and vegetation compartments. Inter-regional transport of contaminants in the atmosphere, freshwater and coastal water is described using a database of hydrological and meteorological data compiled with Geographical Information Systems (GIS) techniques. Steady-state and dynamic solutions to the 168 mass balance equations that make up the linked model for North America are discussed, and an illustrative case study of toxaphene transport from the southern United States to the Great Lakes Basin is presented. Regionally segmented models such as BETR North America can provide a critical link between evaluative models of long-range transport potential and contaminant concentrations observed in remote regions. The continent-scale mass balance calculated by the model provides a sound basis for evaluating long-range transport potential of organic pollutants, and formulation of continent scale management and regulatory strategies for chemicals.

  3. Needle segmentation using 3D Hough transform in 3D TRUS guided prostate transperineal therapy

    SciTech Connect (OSTI)

    Qiu Wu; Yuchi Ming; Ding Mingyue; Tessier, David; Fenster, Aaron

    2013-04-15

    Purpose: Prostate adenocarcinoma is the most common noncutaneous malignancy in American men with over 200 000 new cases diagnosed each year. Prostate interventional therapy, such as cryotherapy and brachytherapy, is an effective treatment for prostate cancer. Its success relies on the correct needle implant position. This paper proposes a robust and efficient needle segmentation method, which acts as an aid to localize the needle in three-dimensional (3D) transrectal ultrasound (TRUS) guided prostate therapy. Methods: The procedure of locating the needle in a 3D TRUS image is a three-step process. First, the original 3D ultrasound image containing a needle is cropped; the cropped image is then converted to a binary format based on its histogram. Second, a 3D Hough transform based needle segmentation method is applied to the 3D binary image in order to locate the needle axis. The position of the needle endpoint is finally determined by an optimal threshold based analysis of the intensity probability distribution. The overall efficiency is improved through implementing a coarse-fine searching strategy. The proposed method was validated in tissue-mimicking agar phantoms, chicken breast phantoms, and 3D TRUS patient images from prostate brachytherapy and cryotherapy procedures by comparison to the manual segmentation. The robustness of the proposed approach was tested by means of varying parameters such as needle insertion angle, needle insertion length, binarization threshold level, and cropping size. Results: The validation results indicate that the proposed Hough transform based method is accurate and robust, with an achieved endpoint localization accuracy of 0.5 mm for agar phantom images, 0.7 mm for chicken breast phantom images, and 1 mm for in vivo patient cryotherapy and brachytherapy images. The mean execution time of needle segmentation algorithm was 2 s for a 3D TRUS image with size of 264 Multiplication-Sign 376 Multiplication-Sign 630 voxels. Conclusions

  4. STATISTICAL STUDY OF CORONAL MASS EJECTIONS WITH AND WITHOUT DISTINCT LOW CORONAL SIGNATURES

    SciTech Connect (OSTI)

    Ma, S.; Attrill, G. D. R.; Golub, L.; Lin, J.

    2010-10-10

    Taking advantage of the two viewpoints of the STEREO spacecraft, we present a statistical study of coronal mass ejections (CMEs) with and without distinct low coronal signatures (LCSs) from 2009 January 1 to August 31. During this period, the lines of sight from STEREO A and B are almost perpendicular and nearly a quarter of the Sun was observed by both. We identified 34 CMEs that originated from around this area and find that (1) about 1 out of 3 CMEs that were studied during 8 months of solar minimum activity are stealth CMEs; a CME is stealth if no distinct LCS (such as coronal dimming, coronal wave, filament eruption, flare, post-eruptive arcade) can be found on the disk. (2) The speeds of the stealth CMEs without LCSs are typically below 300 km s{sup -1}. Comparing with the slow CMEs with LCSs, the stealth CMEs did not show any clear differences in their velocity and acceleration evolution. (3) The source regions of the stealth CMEs are usually located in the quiet Sun rather than active regions. Detailed study indicates that more than half of the stealth CMEs in this paper showed some faint change of the coronal structures (likely parts of flux ropes) when they could be observed over the solar limb before or during the CME evolution. Finally, we note that space weather detection systems based on LCSs totally independent of coronagraph data may fail to detect a significant proportion of CMEs.

  5. Understanding the distinctively skewed and heavy tailed character of atmospheric and oceanic probability distributions

    SciTech Connect (OSTI)

    Sardeshmukh, Prashant D.

    2015-03-15

    The probability distributions of large-scale atmospheric and oceanic variables are generally skewed and heavy-tailed. We argue that their distinctive departures from Gaussianity arise fundamentally from the fact that in a quadratically nonlinear system with a quadratic invariant, the coupling coefficients between system components are not constant but depend linearly on the system state in a distinctive way. In particular, the skewness arises from a tendency of the system trajectory to linger near states of weak coupling. We show that the salient features of the observed non-Gaussianity can be captured in the simplest such nonlinear 2-component system. If the system is stochastically forced and linearly damped, with one component damped much more strongly than the other, then the strongly damped fast component becomes effectively decoupled from the weakly damped slow component, and its impact on the slow component can be approximated as a stochastic noise forcing plus an augmented nonlinear damping. In the limit of large time-scale separation, the nonlinear augmentation of the damping becomes small, and the noise forcing can be approximated as an additive noise plus a correlated additive and multiplicative noise (CAM noise) forcing. Much of the diversity of observed large-scale atmospheric and oceanic probability distributions can be interpreted in this minimal framework.

  6. The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics

    SciTech Connect (OSTI)

    Liu, Tong; Yu, Rong; Jin, Shao-Bo; Han, Liwei; Lendahl, Urban; Zhao, Jian; Nistér, Monica

    2013-11-01

    Mitochondria are dynamic organelles whose morphology is regulated by a complex balance of fission and fusion processes, and we still know relatively little about how mitochondrial dynamics is regulated. MIEF1 (also called MiD51) has recently been characterized as a key regulator of mitochondrial dynamics and in this report we explore the functions of its paralog MIEF2 (also called MiD49), to learn to what extent MIEF2 is functionally distinct from MIEF1. We show that MIEF1 and MIEF2 have many functions in common. Both are anchored in the mitochondrial outer membrane, recruit Drp1 from the cytoplasm to the mitochondrial surface and cause mitochondrial fusion, and MIEF2, like MIEF1, can interact with Drp1 and hFis1. MIEF1 and MIEF2, however, also differ in certain aspects. MIEF1 and MIEF2 are differentially expressed in human tissues during development. When overexpressed, MIEF2 exerts a stronger fusion-promoting effect than MIEF1, and in line with this, hFis1 and Mff can only partially revert the MIEF2-induced fusion phenotype, whereas MIEF1-induced fusion is reverted to a larger extent by hFis1 and Mff. MIEF2 forms high molecular weight oligomers, while MIEF1 is largely present as a dimer. Furthermore, MIEF1 and MIEF2 use distinct domains for oligomerization: in MIEF1, the region from amino acid residues 109–154 is required, whereas oligomerization of MIEF2 depends on amino acid residues 1 to 49, i.e. the N-terminal end. We also show that oligomerization of MIEF1 is not required for its mitochondrial localization and interaction with Drp1. In conclusion, our data suggest that the mitochondrial regulators MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics. - Highlights: • MIEF1 and MIEF2 recruit Drp1 to mitochondria and cause mitochondrial fusion. • MIEF2, like MIEF1, can interact with Drp1 and hFis1. • MIEF1 and MIEF2 are differentially expressed in human tissues during development. • MIEF2 exerts a stronger fusion

  7. Segmented Ultralight Pre-Aligned Rotor for Extreme-Scale Wind Turbines

    SciTech Connect (OSTI)

    Loth, E.; Steele, A.; Ichter, B.; Selig, M.; Moriarty, P.

    2012-01-01

    To alleviate the mass-scaling issues associated with conventional upwind rotors of extreme-scale turbines, a downwind rotor concept is proposed which employs fixed blade curvature based on force alignment at rated conditions. For a given peak stress constraint, the reduction in downwind cantilever loads allows reduced shell and spar thickness, and thus a reduced blade mass as compared with a conventional upwind rotor, especially as rotor sizes approach extreme-scales. To quantify this mass reduction, a Finite Element Analysis was conducted for a 10 MW rated rotor based on the NREL offshore 5 MW baseline wind turbine. The results show that this 'pre-alignment' yields a net downstream deflection of 32 deg, a downward hub-pitch angle of 6 deg, a 20% increase in blade length (to maintain the same radius as the conventional blade), and a net mass savings of about 50% through decreased shell and spar thicknesses. The pre-alignment may also allow a more straightforward and efficient segmentation of the blade since shear stresses near joints are substantially reduced. Segmenting, in turn, can dramatically reduce costs associated with fabrication, transport and assembly for extreme-scale off-shore systems. The pre-aligned geometric curvature can also help alleviate tower wake effects on the blades since blade tips (where shadow effects can be most problematic) are shifted downstream where the tower wake is weaker. In addition, the portion of the tower that is upstream of the blade tips can be faired with an externally-rotating aerodynamic shroud. Furthermore, the downwind rotor can allow a floating off-shore tri-pod platform to reduce tower weight and yaw-control requirements. A simple economic analysis of the segmented ultralight pre-aligned rotor (SUPAR) concept suggests that the overall system cost savings can be as much as 25%, indicating that more detailed (numerical and experimental) investigations are warranted.

  8. A Multiphase Validation of Atlas-Based Automatic and Semiautomatic Segmentation Strategies for Prostate MRI

    SciTech Connect (OSTI)

    Martin, Spencer; Rodrigues, George; Department of Epidemiology Patil, Nikhilesh; Bauman, Glenn; Department of Radiation Oncology, London Regional Cancer Program, London ; D'Souza, David; Sexton, Tracy; Palma, David; Louie, Alexander V.; Khalvati, Farzad; Tizhoosh, Hamid R.; Segasist Technologies, Toronto, Ontario ; Gaede, Stewart

    2013-01-01

    Purpose: To perform a rigorous technological assessment and statistical validation of a software technology for anatomic delineations of the prostate on MRI datasets. Methods and Materials: A 3-phase validation strategy was used. Phase I consisted of anatomic atlas building using 100 prostate cancer MRI data sets to provide training data sets for the segmentation algorithms. In phase II, 2 experts contoured 15 new MRI prostate cancer cases using 3 approaches (manual, N points, and region of interest). In phase III, 5 new physicians with variable MRI prostate contouring experience segmented the same 15 phase II datasets using 3 approaches: manual, N points with no editing, and full autosegmentation with user editing allowed. Statistical analyses for time and accuracy (using Dice similarity coefficient) endpoints used traditional descriptive statistics, analysis of variance, analysis of covariance, and pooled Student t test. Results: In phase I, average (SD) total and per slice contouring time for the 2 physicians was 228 (75), 17 (3.5), 209 (65), and 15 seconds (3.9), respectively. In phase II, statistically significant differences in physician contouring time were observed based on physician, type of contouring, and case sequence. The N points strategy resulted in superior segmentation accuracy when initial autosegmented contours were compared with final contours. In phase III, statistically significant differences in contouring time were observed based on physician, type of contouring, and case sequence again. The average relative timesaving for N points and autosegmentation were 49% and 27%, respectively, compared with manual contouring. The N points and autosegmentation strategies resulted in average Dice values of 0.89 and 0.88, respectively. Pre- and postedited autosegmented contours demonstrated a higher average Dice similarity coefficient of 0.94. Conclusion: The software provided robust contours with minimal editing required. Observed time savings were seen

  9. Total Measurement Uncertainty for the Plutonium Finishing Plant (PFP) Segmented Gamma Scan Assay System

    SciTech Connect (OSTI)

    WESTSIK, G.A.

    2001-06-06

    This report presents the results of an evaluation of the Total Measurement Uncertainty (TMU) for the Canberra manufactured Segmented Gamma Scanner Assay System (SGSAS) as employed at the Hanford Plutonium Finishing Plant (PFP). In this document, TMU embodies the combined uncertainties due to all of the individual random and systematic sources of measurement uncertainty. It includes uncertainties arising from corrections and factors applied to the analysis of transuranic waste to compensate for inhomogeneities and interferences from the waste matrix and radioactive components. These include uncertainty components for any assumptions contained in the calibration of the system or computation of the data. Uncertainties are propagated at 1 sigma. The final total measurement uncertainty value is reported at the 95% confidence level. The SGSAS is a gamma assay system that is used to assay plutonium and uranium waste. The SGSAS system can be used in a stand-alone mode to perform the NDA characterization of a container, particularly for low to medium density (0-2.5 g/cc) container matrices. The SGSAS system provides a full gamma characterization of the container content. This document is an edited version of the Rocky Flats TMU Report for the Can Scan Segment Gamma Scanners, which are in use for the plutonium residues projects at the Rocky Flats plant. The can scan segmented gamma scanners at Rocky Flats are the same design as the PFP SGSAS system and use the same software (with the exception of the plutonium isotopics software). Therefore, all performance characteristics are expected to be similar. Modifications in this document reflect minor differences in the system configuration, container packaging, calibration technique, etc. These results are supported by the Quality Assurance Objective (QAO) counts, safeguards test data, calibration data, etc. for the PFP SGSAS system. Other parts of the TMU analysis utilize various modeling techniques such as Monte Carlo N

  10. Distinctive microstructural features of aged sodium silicate-activated slag concretes

    SciTech Connect (OSTI)

    San Nicolas, Rackel; Bernal, Susan A.; Mejía de Gutiérrez, Ruby; Deventer, Jannie S.J. van; Provis, John L.

    2014-11-15

    Electron microscopic characterisation of 7-year old alkali-activated blast-furnace slag concretes enabled the identification of distinct microstructural features, providing insight into the mechanisms by which these materials evolve over time. Backscattered electron images show the formation of Liesegang-type ring formations, suggesting that the reaction at advanced age is likely to follow an Oswald supersaturation–nucleation–depletion cycle. Segregation of Ca-rich veins, related to the formation of Ca(OH){sub 2}, is observed in microcracked regions due to the ongoing reaction between the pore solution and available calcium from remnant slag grains. A highly dense and uniform interfacial transition zone is identified between siliceous aggregate particles and the alkali activated slag binders, across the concretes assessed. Alkali-activated slag concretes retain a highly dense and stable microstructure at advanced ages, where any microcracks induced at early ages seem to be partially closing, and the remnant slag grains continue reacting.

  11. Distinct water activation on polar/non-polar facets of ZnO nanoparticles

    SciTech Connect (OSTI)

    Zhang, He; Sun, Junming; Liu, Changjun; Wang, Yong

    2015-11-01

    ZnO nanoparticles with differing dominant facets were prepared and characterized by a complimentary of techniques such as X-ray diffraction, electron microscopy, temperature programmed desorption of H2O, and Fourier transform infrared spectroscopy analysis of adsorbed D2O. For the first time, water interaction/activation is compared on ZnO polar and non-polar facets. We report that non-polar facets exhibit high activity in water activation, which favors reactions such as ketonization and steam reforming in which dissociated water is involved. The distinct water dissociation on ZnO non-polar facets could be related to its facile formation of oxygen vacancies under realistic reaction conditions.

  12. Highly polarized light emission by isotropic quantum dots integrated with magnetically aligned segmented nanowires

    SciTech Connect (OSTI)

    Uran, Can; Erdem, Talha; Guzelturk, Burak; Perkgz, Nihan Kosku; Jun, Shinae; Jang, Eunjoo; Demir, Hilmi Volkan

    2014-10-06

    In this work, we demonstrate a proof-of-concept system for generating highly polarized light from colloidal quantum dots (QDs) coupled with magnetically aligned segmented Au/Ni/Au nanowires (NWs). Optical characterizations reveal that the optimized QD-NW coupled structures emit highly polarized light with an s-to p-polarization (s/p) contrast as high as 15:1 corresponding to a degree of polarization of 0.88. These experimental results are supported by the finite-difference time-domain simulations, which demonstrate the interplay between the inter-NW distance and the degree of polarization.

  13. Electrical Signal Path Study and Component Assay for the MAJORANA N-Type Segmented Contact Detector

    SciTech Connect (OSTI)

    Amman, Mark; Bergevin, Marc; Chan, Yuen-Dat; Detwiler, Jason A.; Fujikawa, Brian .; Lesko, Kevin T.; Luke, Paul N.; Prior, Gersende; Poon, Alan W.; Smith, Alan R.; Vetter, Kai; Yaver, Harold; Zimmermann, Sergio

    2009-02-24

    The purpose of the present electrical signal path study is to explore the various issues related to the deployment of highly-segmented low-background Ge detectors for the MAJORANA double-beta decay experiment. A significant challenge is to simultaneously satisfy competing requirements for the mechanical design, electrical readout performance, and radiopurity specifications from the MAJORANA project. Common to all rare search experiments, there is a very stringent limit on the acceptable radioactivity level of all the electronics components involved. Some of the findings are summarized in this report.

  14. Modified SSCP method using sequential electrophoresis of multiple nucleic acid segments

    DOE Patents [OSTI]

    Gatti, Richard A.

    2002-10-01

    The present invention is directed to a method of screening large, complex, polyexonic eukaryotic genes such as the ATM gene for mutations and polymorphisms by an improved version of single strand conformation polymorphism (SSCP) electrophoresis that allows electrophoresis of two or three amplified segments in a single lane. The present invention also is directed to new mutations and polymorphisms in the ATM gene that are useful in performing more accurate screening of human DNA samples for mutations and in distinguishing mutations from polymorphisms, thereby improving the efficiency of automated screening methods.

  15. Population Sensitivity Evaluation of Two Candidate Locations...

    Broader source: Energy.gov (indexed) [DOE]

    Population Sensitivity Evaluation of Two Candidate Locations for Possible Small Modular Reactor Siting (3.84 MB) More Documents & Publications Evaluation of Proposed Hampton Roads ...

  16. Seismic fragility formulations for segmented buried pipeline systems including the impact of differential ground subsidence

    SciTech Connect (OSTI)

    Pineda Porras, Omar Andrey; Ordaz, Mario

    2009-01-01

    Though Differential Ground Subsidence (DGS) impacts the seismic response of segmented buried pipelines augmenting their vulnerability, fragility formulations to estimate repair rates under such condition are not available in the literature. Physical models to estimate pipeline seismic damage considering other cases of permanent ground subsidence (e.g. faulting, tectonic uplift, liquefaction, and landslides) have been extensively reported, not being the case of DGS. The refinement of the study of two important phenomena in Mexico City - the 1985 Michoacan earthquake scenario and the sinking of the city due to ground subsidence - has contributed to the analysis of the interrelation of pipeline damage, ground motion intensity, and DGS; from the analysis of the 48-inch pipeline network of the Mexico City's Water System, fragility formulations for segmented buried pipeline systems for two DGS levels are proposed. The novel parameter PGV{sup 2}/PGA, being PGV peak ground velocity and PGA peak ground acceleration, has been used as seismic parameter in these formulations, since it has shown better correlation to pipeline damage than PGV alone according to previous studies. By comparing the proposed fragilities, it is concluded that a change in the DGS level (from Low-Medium to High) could increase the pipeline repair rates (number of repairs per kilometer) by factors ranging from 1.3 to 2.0; being the higher the seismic intensity the lower the factor.

  17. Machining Test Specimens from Harvested Zion RPV Segments for Through Wall Attenuation Studies

    SciTech Connect (OSTI)

    Rosseel, Thomas M; Sokolov, Mikhail A; Nanstad, Randy K

    2015-01-01

    The decommissioning of the Zion Units 1 and 2 Nuclear Generating Station (NGS) in Zion, Illinois presents a special opportunity for developing a better understanding of materials degradation and other issues associated with extending the lifetime of existing Nuclear Power Plants (NPPs) beyond 60 years of service. In support of extended service and current operations of the US nuclear reactor fleet, the Oak Ridge National Laboratory (ORNL), through the Department of Energy (DOE), Light Water Reactor Sustainability (LWRS) Program, is coordinating and contracting with Zion Solutions, LLC, a subsidiary of Energy Solutions, the selective procurement of materials, structures, and components from the decommissioned reactors. In this paper, we will discuss the acquisition of segments of the Zion Unit 2 Reactor Pressure Vessel (RPV), the cutting of these segments into sections and blocks from the beltline and upper vertical welds and plate material, the current status of machining those blocks into mechanical (Charpy, compact tension, and tensile) test specimens and coupons for chemical and microstructural (TEM, APT, SANS, and nano indention) characterization, as well as the current test plans and possible collaborative projects. Access to service-irradiated RPV welds and plate sections will allow through wall attenuation studies to be performed, which will be used to assess current radiation damage models (Rosseel et al. (2012) and Rosseel et al. (2015)).

  18. Interplay of relativistic and nonrelativistic transport in atomically precise segmented graphene nanoribbons

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yannouleas, Constantine; Romanovsky, Igor; Landman, Uzi

    2015-01-20

    Graphene's isolation launched explorations of fundamental relativistic physics originating from the planar honeycomb lattice arrangement of the carbon atoms, and of potential technological applications in nanoscale electronics. Bottom-up fabricated atomically-precise segmented graphene nanoribbons, SGNRs, open avenues for studies of electrical transport, coherence, and interference effects in metallic, semiconducting, and mixed GNRs, with different edge terminations. Conceptual and practical understanding of electric transport through SGNRs is gained through nonequilibrium Green's function (NEGF) conductance calculations and a Dirac continuum model that absorbs the valence-to-conductance energy gaps as position-dependent masses, including topological-in-origin mass-barriers at the contacts between segments. The continuum model reproduces themore » NEGF results, including optical Dirac Fabry-Pérot (FP) equidistant oscillations for massless relativistic carriers in metallic armchair SGNRs, and an unequally-spaced FP pattern for mixed armchair-zigzag SGNRs where carriers transit from a relativistic (armchair) to a nonrelativistic (zigzag) regime. This provides a unifying framework for analysis of coherent transport phenomena and interpretation of forthcoming experiments in SGNRs.« less

  19. Interplay of relativistic and nonrelativistic transport in atomically precise segmented graphene nanoribbons

    SciTech Connect (OSTI)

    Yannouleas, Constantine; Romanovsky, Igor; Landman, Uzi

    2015-01-20

    Graphene's isolation launched explorations of fundamental relativistic physics originating from the planar honeycomb lattice arrangement of the carbon atoms, and of potential technological applications in nanoscale electronics. Bottom-up fabricated atomically-precise segmented graphene nanoribbons, SGNRs, open avenues for studies of electrical transport, coherence, and interference effects in metallic, semiconducting, and mixed GNRs, with different edge terminations. Conceptual and practical understanding of electric transport through SGNRs is gained through nonequilibrium Green's function (NEGF) conductance calculations and a Dirac continuum model that absorbs the valence-to-conductance energy gaps as position-dependent masses, including topological-in-origin mass-barriers at the contacts between segments. The continuum model reproduces the NEGF results, including optical Dirac Fabry-Pérot (FP) equidistant oscillations for massless relativistic carriers in metallic armchair SGNRs, and an unequally-spaced FP pattern for mixed armchair-zigzag SGNRs where carriers transit from a relativistic (armchair) to a nonrelativistic (zigzag) regime. This provides a unifying framework for analysis of coherent transport phenomena and interpretation of forthcoming experiments in SGNRs.

  20. Covered Sites/Populations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Covered Sites/Populations Covered Sites/Populations Construction Worker Screening Projects Construction Worker Projects, Former Worker Medical Screening Program (FWP) Production Worker Screening Projects Production Worker Projects, Former Worker Medical Screening Program (FWP) National Supplemental Screening Program National Supplemental Screening Program Beryllium Vendor Screening Program Defunct Beryllium Vendor Screening Program

  1. Hanford Area 2000 Population (Technical Report) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Subject: 61 RADIATION PROTECTION AND DOSIMETRY; HANFORD RESERVATION; POPULATION DYNAMICS; HUMAN POPULATIONS; DISTRIBUTION; PUBLIC HEALTH HANFORD SITE; HANFORD AREA DEMOGRAPHICS; ...

  2. Inequivalence of single-particle and population lifetimes in a cuprate superconductor

    SciTech Connect (OSTI)

    Yang, Shuolong; Sobota, J. A.; Leuenberger, D.; He, Y.; Hashimoto, M.; Lu, D. H.; Eisaki, H.; Kirchmann, P. S.; Shen, Z. -X.

    2015-06-15

    We study optimally doped Bi-2212 (Tc=96 K) using femtosecond time- and angle-resolved photoelectron spectroscopy. Energy-resolved population lifetimes are extracted and compared with single-particle lifetimes measured by equilibrium photoemission. The population lifetimes deviate from the single-particle lifetimes in the low excitation limit by 1–2 orders of magnitude. Fundamental considerations of electron scattering unveil that these two lifetimes are in general distinct, yet for systems with only electron-phonon scattering they should converge in the low-temperature, low-fluence limit. As a result, the qualitative disparity in our data, even in this limit, suggests that scattering channels beyond electron-phonon interactions play a significant role in the electron dynamics of cuprate superconductors.

  3. Energy Systems and Population Health

    SciTech Connect (OSTI)

    Ezzati, Majid; Bailis, Rob; Kammen, Daniel M.; Holloway, Tracey; Price, Lynn; Cifuentes, Luis A.; Barnes, Brendon; Chaurey, Akanksha; Dhanapala, Kiran N.

    2004-04-12

    to rural and urban health facilities allows increased delivery and coverage of 3 various health services and interventions such as tests and treatments, better storage of medicine and vaccines, disinfection of medical equipment by boiling or radiation, and more frequent and efficient health system encounters through mobile clinics or longer working hours; and so on. In fact, while the dominant view of development-energy-health linkages has been that improvements in energy and health are outcomes of the socioeconomic development process (e.g., the ''energy ladder'' framework discussed below), it has even been argued that access to higher quality energy sources and technologies can initiate a chain of demographic, health, and development outcomes by changing the household structure and socioeconomic relationships. For example, in addition to increased opportunities for food and income production, reduced infant mortality as a result of transition to cleaner fuels or increased coverage of vaccination with availability of refrigerators in rural clinics may initiate a process of ''demographic transition'' to low-mortality and low-fertility populations (14). Such a transition has historically been followed with further improvements in maternal and child health and increased female participation in the labor markets and other economic activities.

  4. Population Structure of Columbia River Basin Chinook Salmon and Steelhead Trout, Technical Report 2001.

    SciTech Connect (OSTI)

    Brannon, E.L.; National Science Foundation

    2002-08-01

    The population structure of chinook salmon and steelhead trout is presented as an assimilation of the life history forms that have evolved in synchrony with diverse and complex environments over their Pacific range. As poikilotherms, temperature is described as the overwhelming environmental influence that determines what life history options occur and where they are distributed. The different populations represent ecological types referred to as spring-, summer-, fall, and winter-run segments, as well as stream- and ocean-type, or stream- and ocean-maturing life history forms. However, they are more correctly described as a continuum of forms that fall along a temporal cline related to incubation and rearing temperatures that determine spawn timing and juvenile residence patterns. Once new habitats are colonized, members of the founding populations spread through adaptive evolution to assume complementary life history strategies. The related population units are collectively referred to as a metapopulation, and members most closely associated within common temporal and geographic boundaries are designated as first-order metapopulations. Population structure of chinook salmon and steelhead in the Columbia Basin, therefore, is the reflection of the genetic composition of the founding source or sources within the respective region, shaped by the environment, principally temperature, that defines life history evolutionary strategy to maximize fitness under the conditions delineated. The complexity of structure rests with the diversity of opportunities over the elevations that exist within the Basin. Consistent with natural selection, rather than simply attempting to preserve populations, the challenge is to provide opportunities to expand their range to new or restored habitat that can accommodate genetic adaptation as directional environmental changes are elaborated. Artificial propagation can have a critical role in this process, and the emphasis must be placed on

  5. Automatic segmentation of head and neck CT images for radiotherapy treatment planning using multiple atlases, statistical appearance models, and geodesic active contours

    SciTech Connect (OSTI)

    Fritscher, Karl D. Sharp, Gregory; Peroni, Marta; Zaffino, Paolo; Spadea, Maria Francesca; Schubert, Rainer

    2014-05-15

    Purpose: Accurate delineation of organs at risk (OARs) is a precondition for intensity modulated radiation therapy. However, manual delineation of OARs is time consuming and prone to high interobserver variability. Because of image artifacts and low image contrast between different structures, however, the number of available approaches for autosegmentation of structures in the head-neck area is still rather low. In this project, a new approach for automated segmentation of head-neck CT images that combine the robustness of multiatlas-based segmentation with the flexibility of geodesic active contours and the prior knowledge provided by statistical appearance models is presented. Methods: The presented approach is using an atlas-based segmentation approach in combination with label fusion in order to initialize a segmentation pipeline that is based on using statistical appearance models and geodesic active contours. An anatomically correct approximation of the segmentation result provided by atlas-based segmentation acts as a starting point for an iterative refinement of this approximation. The final segmentation result is based on using model to image registration and geodesic active contours, which are mutually influencing each other. Results: 18 CT images in combination with manually segmented labels of parotid glands and brainstem were used in a leave-one-out cross validation scheme in order to evaluate the presented approach. For this purpose, 50 different statistical appearance models have been created and used for segmentation. Dice coefficient (DC), mean absolute distance and max. Hausdorff distance between the autosegmentation results and expert segmentations were calculated. An average Dice coefficient of DC = 0.81 (right parotid gland), DC = 0.84 (left parotid gland), and DC = 0.86 (brainstem) could be achieved. Conclusions: The presented framework provides accurate segmentation results for three important structures in the head neck area. Compared to a

  6. Apparatus for impingement cooling a side wall adjacent an undercut region of a turbine nozzle segment

    DOE Patents [OSTI]

    Burdgick, Steven Sebastian (Schenectady, NY)

    2002-01-01

    A gas turbine nozzle segment has outer and inner bands and vanes therebetween. Each band includes a side wall, a cover and an impingement plate between the cover and nozzle wall defining two cavities on opposite sides of the impingement plate. Cooling steam is supplied to one cavity for flow through apertures of the impingement plate to cool the nozzle wall. The side wall of the band and inturned flange define with the nozzle wall an undercut region. Slots are formed through the inturned flange along the nozzle side wall. A plate having through-apertures extending between opposite edges thereof is disposed in each slot, the slots and plates being angled such that the cooling medium exiting the apertures in the second cavity lie close to the side wall for focusing and targeting cooling medium onto the side wall.

  7. Method of controlling the side wall thickness of a turbine nozzle segment for improved cooling

    DOE Patents [OSTI]

    Burdgick, Steven Sebastian (Schenectady, NY)

    2002-01-01

    A gas turbine nozzle segment has outer and inner bands and a vane extending therebetween. Each band has a side wall, a cover and an impingement plate between the cover and nozzle wall defining two cavities on opposite sides of the impingement plate. Cooling steam is supplied to one cavity for flow through apertures of the impingement plate to cool the nozzle wall. The side wall of the band has an inturned flange defining with the nozzle wall an undercut region. The outer surface of the side wall is provided with a step prior to welding the cover to the side wall. A thermal barrier coating is applied in the step and, after the cover is welded to the side wall, the side wall is finally machined to a controlled thickness removing all, some or none of the coating.

  8. CHARACTERIZING COMPLEXITY IN SOLAR MAGNETOGRAM DATA USING A WAVELET-BASED SEGMENTATION METHOD

    SciTech Connect (OSTI)

    Kestener, P.; Khalil, A.; Arneodo, A.

    2010-07-10

    The multifractal nature of solar photospheric magnetic structures is studied using the two-dimensional wavelet transform modulus maxima (WTMM) method. This relies on computing partition functions from the wavelet transform skeleton defined by the WTMM method. This skeleton provides an adaptive space-scale partition of the fractal distribution under study, from which one can extract the multifractal singularity spectrum. We describe the implementation of a multiscale image processing segmentation procedure based on the partitioning of the WT skeleton, which allows the disentangling of the information concerning the multifractal properties of active regions from the surrounding quiet-Sun field. The quiet Sun exhibits an average Hoelder exponent {approx}-0.75, with observed multifractal properties due to the supergranular structure. On the other hand, active region multifractal spectra exhibit an average Hoelder exponent {approx}0.38, similar to those found when studying experimental data from turbulent flows.

  9. Nondestructive examination of 51 fuel and reflector elements from Fort St. Vrain Core Segment 1

    SciTech Connect (OSTI)

    Miller, C.M.; Saurwein, J.J.

    1980-12-01

    Fifty-one fuel and reflector elements irradiated in core segment 1 of the Fort St. Vrain High-Temperature Gas-Cooled Reactor (HTGR) were inspected dimensionally and visually in the Hot Service Facility at Fort St. Vrain in July 1979. Time- and volume-averaged graphite temperatures for the examined fuel elements ranged from approx. 400/sup 0/ to 750/sup 0/C. Fast neutron fluences varied from approx. 0.3 x 10/sup 25/ n/m/sup 2/ to 1.0 x 10/sup 25/ n/m/sup 2/ (E > 29 fJ)/sub HTGR/. Nearly all of the examined elements shrank in both axial and radial dimensions. The measured data were compared with strain and bow predictions obtained from SURVEY/STRESS, a computer code that employs viscoelastic beam theory to calculate stresses and deformations in HTGR fuel elements.

  10. Nondestructive examination of 54 fuel and reflector elements from Fort St. Vrain core segment 2

    SciTech Connect (OSTI)

    Saurwein, J.J.

    1982-10-01

    Fifty-four fuel and reflector elements irradiated in core segment 2 of the Fort St. Vrain high-temperature gas-cooled reactor (HTGR) were nondestructively examined. The time- and volume-averaged graphite irradiation temperatures for the elements ranged from approx. 350/sup 0/ to 750/sup 0/C. The element-averaged fast neutron fluences ranged from approx. 0.2 to 1.6 x 10/sup 25/ n/m/sup 2/ (E > 29 fJ)/sub HTGR/. The elements, except for two fuel elements in which single localizeed cracks developed during irradiation, were in excellent condition. No evidence was observed of significant graphite oxidation or mechanical interaction beween elements. The cracks in the two elements did not affect their performance or handling. These elements were, otherwise, in excellent condition. Nearly all elements shrank in both the axial and radial directions, but the dimensional changes were relatively small.

  11. Level-set segmentation of pulmonary nodules in megavolt electronic portal images using a CT prior

    SciTech Connect (OSTI)

    Schildkraut, J. S.; Prosser, N.; Savakis, A.; Gomez, J.; Nazareth, D.; Singh, A. K.; Malhotra, H. K.

    2010-11-15

    Purpose: Pulmonary nodules present unique problems during radiation treatment due to nodule position uncertainty that is caused by respiration. The radiation field has to be enlarged to account for nodule motion during treatment. The purpose of this work is to provide a method of locating a pulmonary nodule in a megavolt portal image that can be used to reduce the internal target volume (ITV) during radiation therapy. A reduction in the ITV would result in a decrease in radiation toxicity to healthy tissue. Methods: Eight patients with nonsmall cell lung cancer were used in this study. CT scans that include the pulmonary nodule were captured with a GE Healthcare LightSpeed RT 16 scanner. Megavolt portal images were acquired with a Varian Trilogy unit equipped with an AS1000 electronic portal imaging device. The nodule localization method uses grayscale morphological filtering and level-set segmentation with a prior. The treatment-time portion of the algorithm is implemented on a graphical processing unit. Results: The method was retrospectively tested on eight cases that include a total of 151 megavolt portal image frames. The method reduced the nodule position uncertainty by an average of 40% for seven out of the eight cases. The treatment phase portion of the method has a subsecond execution time that makes it suitable for near-real-time nodule localization. Conclusions: A method was developed to localize a pulmonary nodule in a megavolt portal image. The method uses the characteristics of the nodule in a prior CT scan to enhance the nodule in the portal image and to identify the nodule region by level-set segmentation. In a retrospective study, the method reduced the nodule position uncertainty by an average of 40% for seven out of the eight cases studied.

  12. Apparatus and methods for impingement cooling of an undercut region adjacent a side wall of a turbine nozzle segment

    DOE Patents [OSTI]

    Burdgick, Steven Sebastian (Schenectady, NY); Itzel, Gary Michael (Simpsonville, SC)

    2001-01-01

    A gas turbine nozzle segment has outer and inner bands. Each band includes a side wall, a cover and an impingement plate between the cover and nozzle wall defining two cavities on opposite sides of the impingement plate. Cooling steam is supplied to one cavity for flow through apertures of the impingement plate to cool the nozzle wall. The side wall of the band and inturned flange define with the nozzle wall an undercut region. The inturned flange has a plurality of apertures for directing cooling steam to cool the side wall between adjacent nozzle segments.

  13. Semiautomatic segmentation of aortic valve from sequenced ultrasound image using a novel shape-constraint GCV model

    SciTech Connect (OSTI)

    Guo, Yiting; Dong, Bin; Wang, Bing; Xie, Hongzhi E-mail: gulixu@sjtu.edu.cn; Zhang, Shuyang; Gu, Lixu E-mail: gulixu@sjtu.edu.cn

    2014-07-15

    Purpose: Effective and accurate segmentation of the aortic valve (AV) from sequenced ultrasound (US) images remains a technical challenge because of intrinsic factors of ultrasound images that impact the quality and the continuous changes of shape and position of segmented objects. In this paper, a novel shape-constraint gradient Chan-Vese (GCV) model is proposed for segmenting the AV from time serial echocardiography. Methods: The GCV model is derived by incorporating the energy of the gradient vector flow into a CV model framework, where the gradient vector energy term is introduced by calculating the deviation angle between the inward normal force of the evolution contour and the gradient vector force. The flow force enlarges the capture range and enhances the blurred boundaries of objects. This is achieved by adding a circle-like contour (constructed using the AV structure region as a constraint shape) as an energy item to the GCV model through the shape comparison function. This shape-constrained energy can enhance the image constraint force by effectively connecting separate gaps of the object edge as well as driving the evolution contour to quickly approach the ideal object. Because of the slight movement of the AV in adjacent frames, the initial constraint shape is defined by users, with the other constraint shapes being derived from the segmentation results of adjacent sequence frames after morphological filtering. The AV is segmented from the US images by minimizing the proposed energy function. Results: To evaluate the performance of the proposed method, five assessment parameters were used to compare it with manual delineations performed by radiologists (gold standards). Three hundred and fifteen images acquired from nine groups were analyzed in the experiment. The area-metric overlap error rate was 6.89% ± 2.88%, the relative area difference rate 3.94% ± 2.63%, the average symmetric contour distance 1.08 ± 0.43 mm, the root mean square symmetric

  14. Spatial regulation of a common precursor from two distinct genes generates metabolite diversity

    SciTech Connect (OSTI)

    Guo, Chun -Jun; Sun, Wei -Wen; Bruno, Kenneth S.; Oakley, Berl R.; Keller, Nancy P.; Wang, Clay C. C.

    2015-07-13

    In secondary metabolite biosynthesis, core synthetic genes such as polyketide synthase genes usually encode proteins that generate various backbone precursors. These precursors are modified by other tailoring enzymes to yield a large variety of different secondary metabolites. The number of core synthesis genes in a given species correlates, therefore, with the number of types of secondary metabolites the organism can produce. In our study, heterologous expression of all the A. terreus NRPSlike genes showed that two NRPS-like proteins, encoded by atmelA and apvA, release the same natural product, aspulvinone E. In hyphae this compound is converted to aspulvinones whereas in conidia it is converted to melanin. The genes are expressed in different tissues and this spatial control is probably regulated by their own specific promoters. Comparative genomics indicates that atmelA and apvA might share a same ancestral gene and the gene apvA is located in a highly conserved region in Aspergillus species that contains genes coding for life-essential proteins. Our data reveal the first case in secondary metabolite biosynthesis in which the tissue specific production of a single compound directs it into two separate pathways, producing distinct compounds with different functions. Our data also reveal that a single trans-prenyltransferase, AbpB, prenylates two substrates, aspulvinones and butyrolactones, revealing that genes outside of contiguous secondary metabolism gene clusters can modify more than one compound thereby expanding metabolite diversity. Our study raises the possibility of incorporation of spatial, cell-type specificity in expression of secondary metabolites of biological interest and provides new insight into designing and reconstituting their biosynthetic pathways.

  15. Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

    SciTech Connect (OSTI)

    Gilks, C. Blake; Press, Joshua Z.; De Luca, Alessandro; Boyd, Niki; Young, Sean; Troussard, Armelle; Ridge, Yolanda; Kaurah, Pardeep; Kalloger, Steve E.; Blood, Katherine A.; Smith, Margaret; Spellman, Paul T.; Wang, Yuker; Miller, Dianne M.; Horsman, Doug; Faham, Malek; Gilks, C. Blake; Gray, Joe; Huntsman, David G.

    2008-05-02

    Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can lead to decreased expression of BRCA1/2 in ovarian cancers. The mechanism of BRCA1/2 loss is a potential method of subclassifying high grade serous carcinomas. A consecutive series of 49 ovarian cancers was assessed for mutations status of BRCA1 and BRCA2, LOH at the BRCA1 and BRCA2 loci, methylation of the BRCA1 promoter, BRCA1, BRCA2, PTEN, and PIK3CA transcript levels, PIK3CA gene copy number, and BRCA1, p21, p53, and WT-1 immunohistochemistry. Eighteen (37%) of the ovarian carcinomas had germline or somatic BRCA1 mutations, or epigenetic loss of BRCA1. All of these tumors were high-grade serous or undifferentiated type. None of the endometrioid (n=5), clear cell (n=4), or low grade serous (n=2) carcinomas showed loss of BRCA1, whereas 47% of the 38 high-grade serous or undifferentiated carcinomas had loss of BRCA1. It was possible to distinguish high grade serous carcinomas with BRCA1 mutations from those with epigenetic BRCA1 loss: tumors with BRCA1 mutations typically had decreased PTEN mRNA levels while those with epigenetic loss of BRCA1 had copy number gain of PIK3CA. Overexpression of p53 with loss of p21 expression occurred significantly more frequently in high grade serous carcinomas with epigenetic loss of BRCA1, compared to high grade serous tumors without loss of BRCA1. High grade serous carcinomas can be subclassified into three groups: BRCA1 loss (genetic), BRCA1 loss (epigenetic), and no BRCA1 loss. Tumors in these groups show distinct molecular alterations involving the PI3K/AKT and p53 pathways.

  16. Spatial regulation of a common precursor from two distinct genes generates metabolite diversity

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Guo, Chun -Jun; Sun, Wei -Wen; Bruno, Kenneth S.; Oakley, Berl R.; Keller, Nancy P.; Wang, Clay C. C.

    2015-07-13

    In secondary metabolite biosynthesis, core synthetic genes such as polyketide synthase genes usually encode proteins that generate various backbone precursors. These precursors are modified by other tailoring enzymes to yield a large variety of different secondary metabolites. The number of core synthesis genes in a given species correlates, therefore, with the number of types of secondary metabolites the organism can produce. In our study, heterologous expression of all the A. terreus NRPSlike genes showed that two NRPS-like proteins, encoded by atmelA and apvA, release the same natural product, aspulvinone E. In hyphae this compound is converted to aspulvinones whereas inmore » conidia it is converted to melanin. The genes are expressed in different tissues and this spatial control is probably regulated by their own specific promoters. Comparative genomics indicates that atmelA and apvA might share a same ancestral gene and the gene apvA is located in a highly conserved region in Aspergillus species that contains genes coding for life-essential proteins. Our data reveal the first case in secondary metabolite biosynthesis in which the tissue specific production of a single compound directs it into two separate pathways, producing distinct compounds with different functions. Our data also reveal that a single trans-prenyltransferase, AbpB, prenylates two substrates, aspulvinones and butyrolactones, revealing that genes outside of contiguous secondary metabolism gene clusters can modify more than one compound thereby expanding metabolite diversity. Our study raises the possibility of incorporation of spatial, cell-type specificity in expression of secondary metabolites of biological interest and provides new insight into designing and reconstituting their biosynthetic pathways.« less

  17. Distinctive Oxidative Stress Responses to Hydrogen Peroxide in Sulfate Reducing Bacteria Desulfovibrio vulgaris Hildenborough

    SciTech Connect (OSTI)

    Zhou, Aifen; He, Zhili; Redding, A.M.; Mukhopadhyay, Aindrila; Hemme, Christopher L.; Joachimiak, Marcin P.; Bender, Kelly S.; Keasling, Jay D.; Stahl, David A.; Fields, Matthew W.; Hazen, Terry C.; Arkin, Adam P.; Wall, Judy D.; Zhou, Jizhong

    2009-01-01

    Response of Desulfovibrio vulgaris Hildenborough to hydrogen peroxide (H2O2, 1 mM) was investigated with transcriptomic, proteomic and genetic approaches. Microarray data demonstrated that gene expression was extensively affected by H2O2 with the response peaking at 120 min after H2O2 treatment. Genes affected include those involved with energy production, sulfate reduction, ribosomal structure and translation, H2O2 scavenging, posttranslational modification and DNA repair as evidenced by gene coexpression networks generated via a random matrix-theory based approach. Data from this study support the hypothesis that both PerR and Fur play important roles in H2O2-induced oxidative stress response. First, both PerR and Fur regulon genes were significantly up-regulated. Second, predicted PerR regulon genes ahpC and rbr2 were derepressedin Delta PerR and Delta Fur mutants and induction of neither gene was observed in both Delta PerR and Delta Fur when challenged with peroxide, suggesting possible overlap of these regulons. Third, both Delta PerR and Delta Fur appeared to be more tolerant of H2O2 as measured by optical density. Forth, proteomics data suggested de-repression of Fur during the oxidative stress response. In terms of the intracellular enzymatic H2O2 scavenging, gene expression data suggested that Rdl and Rbr2 may play major roles in the detoxification of H2O2. In addition, induction of thioredoxin reductase and thioredoxin appeared to be independent of PerR and Fur. Considering all data together, D. vulgaris employed a distinctive stress resistance mechanism to defend against increased cellular H2O2, and the temporal gene expression changes were consistent with the slowdown of cell growth at the onset of oxidative stress.

  18. High-precision flexible fabrication of tissue engineering scaffolds using distinct polymers

    SciTech Connect (OSTI)

    Wei, Chuang; Cai, Lei; Sonawane, Bhushan; Wang, Shanfeng; Dong, Jingyan

    2012-01-01

    Three-dimensional porous structures using biodegradable materials with excellent biocompatibility are critically important for tissue engineering applications. We present a multi-nozzle-based versatile deposition approach to flexibly construct porous tissue engineering scaffolds using distinct polymeric biomaterials such as thermoplastic and photo-crosslinkable polymers. We first describe the development of the deposition system and fabrication of scaffolds from two types of biodegradable polymers using this system. The thermoplastic sample is semi-crystalline poly({var_epsilon}-caprolactone) (PCL) that can be processed at a temperature higher than its melting point and solidifies at room temperature. The photo-crosslinkable one is polypropylene fumarate (PPF) that has to be dissolved in a reactive solvent as a resin for being cured into solid structures. Besides the direct fabrication of thermoplastic PCL scaffolds, we specifically develop a layer molding approach for the fabrication of crosslinkable polymers, which traditionally can only be fabricated by stereolithography. In this approach, a thermoplastic supporting material (paraffin wax) is first deposited to make a mold for each specific layer, and then PPF is deposited on demand to fill the mold and cured by the UV light. The supporting material can be removed to produce a porous scaffold of crosslinked PPF. Both PCL and crosslinked PPF scaffolds fabricated using the developed system have been characterized in terms of compressive mechanical properties, morphology, pore size and porosity. Mouse MC3T3-E1 pre-osteoblastic cell studies on the fabricated scaffolds have been performed to demonstrate their capability of supporting cell proliferation and ingrowth, aiming for bone tissue engineering applications.

  19. Hanford Site Regional Population - 2010 Census

    SciTech Connect (OSTI)

    Hamilton, Erin L.; Snyder, Sandra F.

    2011-08-12

    The U.S. Department of Energy conducts radiological operations in south-central Washington State. Population dose estimates must be performed to provide a measure of the impact from site radiological releases. Results of the U.S. 2010 Census were used to determine counts and distributions for the residential population located within 50-miles of several operating areas of the Hanford Site. Year 2010 was the first census year that a 50-mile population of a Hanford Site operational area exceeded the half-million mark.

  20. Estimating Traveler Populations at Airport and Cruise Terminals for Population Distribution and Dynamics

    SciTech Connect (OSTI)

    Jochem, Warren C; Sims, Kelly M; Bright, Eddie A; Urban, Marie L; Rose, Amy N; Coleman, Phil R; Bhaduri, Budhendra L

    2013-01-01

    In recent years, uses of high-resolution population distribution databases are increasing steadily for environmental, socioeconomic, public health, and disaster-related research and operations. With the development of daytime population distribution, temporal resolution of such databases has been improved. However, the lack of incorporation of transitional population, namely business and leisure travelers, leaves a significant population unaccounted for within the critical infrastructure networks, such as at transportation hubs. This paper presents two general methodologies for estimating passenger populations in airport and cruise port terminals at a high temporal resolution which can be incorporated into existing population distribution models. The methodologies are geographically scalable and are based on, and demonstrate how, two different transportation hubs with disparate temporal population dynamics can be modeled utilizing publicly available databases including novel data sources of flight activity from the Internet which are updated in near-real time. The airport population estimation model shows great potential for rapid implementation for a large collection of airports on a national scale, and the results suggest reasonable accuracy in the estimated passenger traffic. By incorporating population dynamics at high temporal resolutions into population distribution models, we hope to improve the estimates of populations exposed to or at risk to disasters, thereby improving emergency planning and response, and leading to more informed policy decisions.

  1. Method for spatially distributing a population

    SciTech Connect (OSTI)

    Bright, Edward A; Bhaduri, Budhendra L; Coleman, Phillip R; Dobson, Jerome E

    2007-07-24

    A process for spatially distributing a population count within a geographically defined area can include the steps of logically correlating land usages apparent from a geographically defined area to geospatial features in the geographically defined area and allocating portions of the population count to regions of the geographically defined area having the land usages, according to the logical correlation. The process can also include weighing the logical correlation for determining the allocation of portions of the population count and storing the allocated portions within a searchable data store. The logically correlating step can include the step of logically correlating time-based land usages to geospatial features of the geographically defined area. The process can also include obtaining a population count for the geographically defined area, organizing the geographically defined area into a plurality of sectors, and verifying the allocated portions according to direct observation.

  2. Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish

    SciTech Connect (OSTI)

    Goodale, Britton C.; Tilton, Susan C.; Corvi, Margaret M.; Wilson, Glenn R.; Janszen, Derek B.; Anderson, Kim A.; Waters, Katrina M.; Tanguay, Robert L.

    2013-11-01

    changes induced by developmental exposure to PAHs Determined PAH body burdens following developmental exposure Genes uniquely induced by benz(a)anthracene included targets of the AHR and RELA Dibenzothiophene and pyrene perturbed a distinct RELA network Transcriptional networks reveal differential mechanisms of PAH toxicity.

  3. 3D automatic anatomy segmentation based on iterative graph-cut-ASM

    SciTech Connect (OSTI)

    Chen, Xinjian; Bagci, Ulas

    2011-08-15

    Purpose: This paper studies the feasibility of developing an automatic anatomy segmentation (AAS) system in clinical radiology and demonstrates its operation on clinical 3D images. Methods: The AAS system, the authors are developing consists of two main parts: object recognition and object delineation. As for recognition, a hierarchical 3D scale-based multiobject method is used for the multiobject recognition task, which incorporates intensity weighted ball-scale (b-scale) information into the active shape model (ASM). For object delineation, an iterative graph-cut-ASM (IGCASM) algorithm is proposed, which effectively combines the rich statistical shape information embodied in ASM with the globally optimal delineation capability of the GC method. The presented IGCASM algorithm is a 3D generalization of the 2D GC-ASM method that they proposed previously in Chen et al.[Proc. SPIE, 7259, 72590C1-72590C-8 (2009)]. The proposed methods are tested on two datasets comprised of images obtained from 20 patients (10 male and 10 female) of clinical abdominal CT scans, and 11 foot magnetic resonance imaging (MRI) scans. The test is for four organs (liver, left and right kidneys, and spleen) segmentation, five foot bones (calcaneus, tibia, cuboid, talus, and navicular). The recognition and delineation accuracies were evaluated separately. The recognition accuracy was evaluated in terms of translation, rotation, and scale (size) error. The delineation accuracy was evaluated in terms of true and false positive volume fractions (TPVF, FPVF). The efficiency of the delineation method was also evaluated on an Intel Pentium IV PC with a 3.4 GHZ CPU machine. Results: The recognition accuracies in terms of translation, rotation, and scale error over all organs are about 8 mm, 10 deg. and 0.03, and over all foot bones are about 3.5709 mm, 0.35 deg. and 0.025, respectively. The accuracy of delineation over all organs for all subjects as expressed in TPVF and FPVF is 93.01% and 0.22%, and

  4. New thermal model with distinct freeze-out temperatures for baryons and mesons

    SciTech Connect (OSTI)

    De Assis, Leonardo P. G.; Duarte, Sergio B.; Chiapparini, Marcelo; Hirsch, Luciana R.; Delfino, Antonio Jr.

    2013-05-06

    A significant amount of experimental data for particle production in high-energy heavy ion collisions (10 - 200 GeV/A at center of mass) has been accumulated during last years. Many different theoretical attempts have tried to describe these data using thermal models in the approximation of global thermal equilibrium considering only one freeze-out temperature. However the thermal models often are not able to describe adequately the whole multiplicities of hadrons. For instance, the abundance of strange particles is overestimate and the pion yields are underestimated. In this work is presented a thermal hadronic model with two different temperatures in order to describe the baryonic and mesonic chemical freeze-out in ultra-relativistic heavy ion collisions. The model is used to fit the particle population ratios of the hadrons produced in the reaction. The proposal is not merely to incorporate one additional degree of freedom in the adjustment procedure of data, but to present and alternative scenario for the freeze out stage in the collisional proces s. This new reformulated version of thermal model was applied to a set of data, offering a rather good improvement in the fitting of the calculated particle ratios to the data. The results suggest that the introduced model makes the thermal approach more robust to handle with a larger number of colliding systems and a more comprehensive set of reaction observables.

  5. Evidence for two distinct stellar initial mass functions: probing for clues to the dichotomy

    SciTech Connect (OSTI)

    Zaritsky, Dennis; Colucci, Janet E.; Bernstein, Rebecca A.; Pessev, Peter M.

    2014-12-01

    We present new measurements of the velocity dispersions of 11 Local Group globular clusters using spatially integrated spectra, to expand our sample of clusters with precise integrated-light velocity dispersions to 29, over 4 different host galaxies. This sample allows us to further our investigation of the stellar mass function among clusters, with a particular emphasis on a search for the driver of the apparent bimodal nature of the inferred stellar initial mass function (IMF). We confirm our previous result that clusters fall into two classes. If, as we argue, this behavior reflects a variation in the stellar IMF, the cause of that variation is not clear. The variations do not correlate with formation epoch as quantified by age, metallicity quantified by [Fe/H], host galaxy, or internal structure as quantified by velocity dispersion, physical size, relaxation time, or luminosity. The stellar mass-to-light ratios, Y{sub *}, of the high and low Y{sub *} cluster populations are well-matched to those found in recent studies of early and late type galaxies, respectively.

  6. TU-F-18A-03: Improving Tissue Segmentation for Monte Carlo Dose Calculation Using DECT Data

    SciTech Connect (OSTI)

    Di, Salvio A; Bedwani, S; Carrier, J

    2014-06-15

    Purpose: To develop a new segmentation technique using dual energy CT (DECT) to overcome limitations related to segmentation from a standard Hounsfield unit (HU) to electron density (ED) calibration curve. Both methods are compared with a Monte Carlo analysis of dose distribution. Methods: DECT allows a direct calculation of both ED and effective atomic number (EAN) within a given voxel. The EAN is here defined as a function of the total electron cross-section of a medium. These values can be effectively acquired using a calibrated method from scans at two different energies. A prior stoichiometric calibration on a Gammex RMI phantom allows us to find the parameters to calculate EAN and ED within a voxel. Scans from a Siemens SOMATOM Definition Flash dual source system provided the data for our study. A Monte Carlo analysis compares dose distribution simulated by dosxyz-nrc, considering a head phantom defined by both segmentation techniques. Results: Results from depth dose and dose profile calculations show that materials with different atomic compositions but similar EAN present differences of less than 1%. Therefore, it is possible to define a short list of basis materials from which density can be adapted to imitate interaction behavior of any tissue. Comparison of the dose distributions on both segmentations shows a difference of 50% in dose in areas surrounding bone at low energy. Conclusion: The presented segmentation technique allows a more accurate medium definition in each voxel, especially in areas of tissue transition. Since the behavior of human tissues is highly sensitive at low energies, this reduces the errors on calculated dose distribution. This method could be further developed to optimize the tissue characterization based on anatomic site.

  7. SU-E-J-252: Reproducibility of Radiogenomic Image Features: Comparison of Two Semi-Automated Segmentation Methods

    SciTech Connect (OSTI)

    Lee, M; Woo, B; Kim, J; Jamshidi, N; Kuo, M

    2015-06-15

    Purpose: Objective and reliable quantification of imaging phenotype is an essential part of radiogenomic studies. We compared the reproducibility of two semi-automatic segmentation methods for quantitative image phenotyping in magnetic resonance imaging (MRI) of glioblastoma multiforme (GBM). Methods: MRI examinations with T1 post-gadolinium and FLAIR sequences of 10 GBM patients were downloaded from the Cancer Image Archive site. Two semi-automatic segmentation tools with different algorithms (deformable model and grow cut method) were used to segment contrast enhancement, necrosis and edema regions by two independent observers. A total of 21 imaging features consisting of area and edge groups were extracted automatically from the segmented tumor. The inter-observer variability and coefficient of variation (COV) were calculated to evaluate the reproducibility. Results: Inter-observer correlations and coefficient of variation of imaging features with the deformable model ranged from 0.953 to 0.999 and 2.1% to 9.2%, respectively, and the grow cut method ranged from 0.799 to 0.976 and 3.5% to 26.6%, respectively. Coefficient of variation for especially important features which were previously reported as predictive of patient survival were: 3.4% with deformable model and 7.4% with grow cut method for the proportion of contrast enhanced tumor region; 5.5% with deformable model and 25.7% with grow cut method for the proportion of necrosis; and 2.1% with deformable model and 4.4% with grow cut method for edge sharpness of tumor on CE-T1W1. Conclusion: Comparison of two semi-automated tumor segmentation techniques shows reliable image feature extraction for radiogenomic analysis of GBM patients with multiparametric Brain MRI.

  8. Sampling strategies for subsampled segmented EPI PRF thermometry in MR guided high intensity focused ultrasound

    SciTech Connect (OSTI)

    Oden, Henrik Diakite, Mahamadou; Todd, Nick; Minalga, Emilee; Payne, Allison; Parker, Dennis L.

    2014-09-15

    Purpose: To investigate k-space subsampling strategies to achieve fast, large field-of-view (FOV) temperature monitoring using segmented echo planar imaging (EPI) proton resonance frequency shift thermometry for MR guided high intensity focused ultrasound (MRgHIFU) applications. Methods: Five different k-space sampling approaches were investigated, varying sample spacing (equally vs nonequally spaced within the echo train), sampling density (variable sampling density in zero, one, and two dimensions), and utilizing sequential or centric sampling. Three of the schemes utilized sequential sampling with the sampling density varied in zero, one, and two dimensions, to investigate sampling the k-space center more frequently. Two of the schemes utilized centric sampling to acquire the k-space center with a longer echo time for improved phase measurements, and vary the sampling density in zero and two dimensions, respectively. Phantom experiments and a theoretical point spread function analysis were performed to investigate their performance. Variable density sampling in zero and two dimensions was also implemented in a non-EPI GRE pulse sequence for comparison. All subsampled data were reconstructed with a previously described temporally constrained reconstruction (TCR) algorithm. Results: The accuracy of each sampling strategy in measuring the temperature rise in the HIFU focal spot was measured in terms of the root-mean-square-error (RMSE) compared to fully sampled truth. For the schemes utilizing sequential sampling, the accuracy was found to improve with the dimensionality of the variable density sampling, giving values of 0.65?C, 0.49?C, and 0.35?C for density variation in zero, one, and two dimensions, respectively. The schemes utilizing centric sampling were found to underestimate the temperature rise, with RMSE values of 1.05?C and 1.31?C, for variable density sampling in zero and two dimensions, respectively. Similar subsampling schemes with variable

  9. Impact of Resolution on Simulation of Closed Mesoscale Cellular Convection Identified by Dynamically Guided Watershed Segmentation

    SciTech Connect (OSTI)

    Martini, Matus; Gustafson, William I.; Yang, Qing; Xiao, Heng

    2014-11-27

    Organized mesoscale cellular convection (MCC) is a common feature of marine stratocumulus that forms in response to a balance between mesoscale dynamics and smaller scale processes such as cloud radiative cooling and microphysics. We use the Weather Research and Forecasting model with chemistry (WRF-Chem) and fully coupled cloud-aerosol interactions to simulate marine low clouds during the VOCALS-REx campaign over the southeast Pacific. A suite of experiments with 3- and 9-km grid spacing indicates resolution-dependent behavior. The simulations with finer grid spacing have smaller liquid water paths and cloud fractions, while cloud tops are higher. The observed diurnal cycle is reasonably well simulated. To isolate organized MCC characteristics we develop a new automated method, which uses a variation of the watershed segmentation technique that combines the detection of cloud boundaries with a test for coincident vertical velocity characteristics. This ensures that the detected cloud fields are dynamically consistent for closed MCC, the most common MCC type over the VOCALS-REx region. We demonstrate that the 3-km simulation is able to reproduce the scaling between horizontal cell size and boundary layer height seen in satellite observations. However, the 9-km simulation is unable to resolve smaller circulations corresponding to shallower boundary layers, instead producing invariant MCC horizontal scale for all simulated boundary layers depths. The results imply that climate models with grid spacing of roughly 3 km or smaller may be needed to properly simulate the MCC structure in the marine stratocumulus regions.

  10. High temperature spin dynamics in linear magnetic chains, molecular rings, and segments by nuclear magnetic resonance

    SciTech Connect (OSTI)

    Adelnia, Fatemeh; Lascialfari, Alessandro; Mariani, Manuel; Ammannato, Luca; Caneschi, Andrea; Rovai, Donella; Winpenny, Richard; Timco, Grigore; Corti, Maurizio Borsa, Ferdinando

    2015-05-07

    We present the room temperature proton nuclear magnetic resonance (NMR) nuclear spin-lattice relaxation rate (NSLR) results in two 1D spin chains: the Heisenberg antiferromagnetic (AFM) Eu(hfac){sub 3}NITEt and the magnetically frustrated Gd(hfac){sub 3}NITEt. The NSLR as a function of external magnetic field can be interpreted very well in terms of high temperature spin dynamics dominated by a long time persistence of the decay of the two-spin correlation function due to the conservation of the total spin value for isotropic Heisenberg chains. The high temperature spin dynamics are also investigated in Heisenberg AFM molecular rings. In both Cr{sub 8} closed ring and in Cr{sub 7}Cd and Cr{sub 8}Zn open rings, i.e., model systems for a finite spin segment, an enhancement of the low frequency spectral density is found consistent with spin diffusion but the high cut-off frequency due to intermolecular anisotropic interactions prevents a detailed analysis of the spin diffusion regime.

  11. Sensitivity and specificity of whole chromosome paint (WCP) probes are correlated with size of translocated segment

    SciTech Connect (OSTI)

    Qumsiyeh, M.B.; Peppers, J.A.

    1996-10-16

    Wiley et al. reported on a de novo {open_quotes}non-reciprocal translocation 1;8{close_quotes} as {open_quotes}confirmed{close_quotes} by whole chromosome paints (WCP). The assumption in this and similar papers is that WCP for one chromosome would light the ends of a derivative chromosome if the derivative chromosome carries such material and that the signal would be missing from donor chromosome. However, it has been our experience that WCP do not rule out reciprocal translocations involving small segments. Our lab has had three recent relevant examples: Case 1: A t(4;5)(p16.3;p15.3)mat. The initial discovery by G-banding was of a small piece of extra material on 4p in mother and child. Initial trials using a paint 4 probe on the mother`s metaphases, both in our laboratory and in another laboratory, failed to show signal on any other chromosome. The reciprocal 4;5 nature was demonstrated later using a cosmid to 4p. Painting with a chromosome 5 probe on metaphases from the mother with the rcp(4;5) showed apparently complete painting of both chromosome 5s in all cells. The signal from the WCP 5 probe on the derivative 4 was seen as a very small signal in only 30% of the cells. 4 refs.

  12. Who Will More Likely Buy PHEV: A Detailed Market Segmentation Analysis

    SciTech Connect (OSTI)

    Lin, Zhenhong; Greene, David L

    2010-01-01

    Understanding the diverse PHEV purchase behaviors among prospective new car buyers is key for designing efficient and effective policies for promoting new energy vehicle technologies. The ORNL MA3T model developed for the U.S. Department of Energy is described and used to project PHEV purchase probabilities by different consumers. MA3T disaggregates the U.S. household vehicle market into 1458 consumer segments based on region, residential area, driver type, technology attitude, home charging availability and work charging availability and is calibrated to the EIA s Annual Energy Outlook. Simulation results from MA3T are used to identify the more likely PHEV buyers and provide explanations. It is observed that consumers who have home charging, drive more frequently and live in urban area are more likely to buy a PHEV. Early adopters are projected to be more likely PHEV buyers in the early market, but the PHEV purchase probability by the late majority consumer can increase over time when PHEV gradually becomes a familiar product. Copyright Form of EVS25.

  13. Femtosecond Population Inversion and Stimulated Emission of Dense...

    Office of Scientific and Technical Information (OSTI)

    Femtosecond Population Inversion and Stimulated Emission of Dense Dirac Fermions in Graphene Citation Details In-Document Search Title: Femtosecond Population Inversion and...

  14. Core-Collapse Supernovae and Host Galaxy Stellar Populations...

    Office of Scientific and Technical Information (OSTI)

    Core-Collapse Supernovae and Host Galaxy Stellar Populations Citation Details In-Document Search Title: Core-Collapse Supernovae and Host Galaxy Stellar Populations Authors: Kelly, ...

  15. EO 12898: Environmental Justice in Minority Populations and Low...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EO 12898: Environmental Justice in Minority Populations and Low-Income Populations To focus Federal attention on the environmental and human health conditions in minority ...

  16. Environmental Impacts of Wind Power Development on the Population...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Impacts of Wind Power Development on the Population Biology of Greater Prairie-Chickens Environmental Impacts of Wind Power Development on the Population Biology of Greater ...

  17. The Other 15%: Expanding Energy Efficiency to Rural Populations...

    Energy Savers [EERE]

    The Other 15%: Expanding Energy Efficiency to Rural Populations The Other 15%: Expanding Energy Efficiency to Rural Populations Better Buildings Residential Network Peer Exchange ...

  18. Levels of toxic elements and functional structure in populations of small mammals under conditions of technogenic pollution (with reference to the bank vole)

    SciTech Connect (OSTI)

    Mukhacheva, S.V.; Bezel, V.S.

    1995-05-01

    The levels and the character of accumulation of heavy metals (Pb, Cd, Cu, Zn) in organs and tissues of bank voles, living under conditions of technogenic pollution (near a copper-smelting plant) and on the control territory, were studied. The fundamental distinctions in the character of accumulation of physiologically extraneous elements (lead and cadmium) and elements required for normal functioning (copper and zinc) were found. It was shown that the bank vole population responds to technogenic pollution of the environment depending on the ecological-functional features of the subpopulational groups that form this population. 4 refs., 3 figs., 2 tabs.

  19. Endogenous field feedback promotes the detectability for exogenous electric signal in the hybrid coupled population

    SciTech Connect (OSTI)

    Wei, Xile; Zhang, Danhong; Wang, Jiang; Yu, Haitao; Lu, Meili; Che, Yanqiu

    2015-01-15

    This paper presents the endogenous electric field in chemical or electrical synaptic coupled networks, aiming to study the role of endogenous field feedback in the signal propagation in neural systems. It shows that the feedback of endogenous fields to network activities can reduce the required energy of the noise and enhance the transmission of input signals in hybrid coupled populations. As a common and important nonsynaptic interactive method among neurons, particularly, the endogenous filed feedback can not only promote the detectability of exogenous weak signal in hybrid coupled neural population but also enhance the robustness of the detectability against noise. Furthermore, with the increasing of field coupling strengths, the endogenous field feedback is conductive to the stochastic resonance by facilitating the transition of cluster activities from the no spiking to spiking regions. Distinct from synaptic coupling, the endogenous field feedback can play a role as internal driving force to boost the population activities, which is similar to the noise. Thus, it can help to transmit exogenous weak signals within the network in the absence of noise drive via the stochastic-like resonance.

  20. Potential of the tractor-trailer and container segments as entry markets for a proposed refrigeration technology

    SciTech Connect (OSTI)

    Smith, S.A.; Davis, L.J.; Garrett, B.A.

    1987-05-01

    The refrigerated trailer and container segments of the transportation industry are evaluated as potential entry markets for a proposed absorption refrigeration technology. To perform this analysis the existing transportation refrigeration industry is characterized; this includes a description of the current refrigeration technology, rating systems, equipment manufacturers, maintenance requirements, and sales trends. This information indicates that the current transportation refrigeration industry is composed of two major competitors, Thermo King and Carrier. In addition, it has low profit potential, some barriers to entry and low growth potential. Data are also presented that characterize the transportation refrigeration consumers, specifically, major groups, market segmentation, consumer decision process, and buying criteria. This consumer information indicates that the majority of refrigerated trailer consumers are private carriers, and that the majority of refrigerated container consumers are shipping companies. Also, these consumers are primarily interested in buying reliable equipment at a low price, and are quite satisfied with existing refrigeration equipment.

  1. ELECTROCHEMICAL CORROSION STUDIES FOR TANK 241-AN-107 CORE 309 SEGMENTS 21R1 & 21R2

    SciTech Connect (OSTI)

    DUNCAN JB

    2007-11-13

    Liquid waste in tank 241-AN-107 is below Technical Safety Requirements Administrative Control 5.16 (AC 5.16) limits. Electrochemical corrosion testing was performed on Core 309, Segments 21R1 and 21R2, to provide information on the conductivity and corrosive tendencies of the tank saltcake and interstitial liquid. This report describes data obtained under the execution of RPP-PLAN-29001, 'Electrochemical Corrosion Studies for Tank 241-AN-107 Core 309, Segments 21R1 and 21R2'. Analytical results are presented that show supernatant was within the limits while the interstitial liquid remained below the limits for the analytical cores. Applicable AC 5.16 chemistry control limits for AN-107 are presented.

  2. Evaluation of atlas-based auto-segmentation software in prostate cancer patients

    SciTech Connect (OSTI)

    Greenham, Stuart; Dean, Jenna; Fu, Cheuk Kuen Kenneth; Goman, Joanne; Mulligan, Jeremy; Tune, Deanna; Sampson, David; Westhuyzen, Justin; McKay, Michael

    2014-09-15

    The performance and limitations of an atlas-based auto-segmentation software package (ABAS; Elekta Inc.) was evaluated using male pelvic anatomy as the area of interest. Contours from 10 prostate patients were selected to create atlases in ABAS. The contoured regions of interest were created manually to align with published guidelines and included the prostate, bladder, rectum, femoral heads and external patient contour. Twenty-four clinically treated prostate patients were auto-contoured using a randomised selection of two, four, six, eight or ten atlases. The concordance between the manually drawn and computer-generated contours were evaluated statistically using Pearson's product–moment correlation coefficient (r) and clinically in a validated qualitative evaluation. In the latter evaluation, six radiation therapists classified the degree of agreement for each structure using seven clinically appropriate categories. The ABAS software generated clinically acceptable contours for the bladder, rectum, femoral heads and external patient contour. For these structures, ABAS-generated volumes were highly correlated with ‘as treated’ volumes, manually drawn; for four atlases, for example, bladder r = 0.988 (P < 0.001), rectum r = 0.739 (P < 0.001) and left femoral head r = 0.560 (P < 0.001). Poorest results were seen for the prostate (r = 0.401, P < 0.05) (four atlases); however this was attributed to the comparison prostate volume being contoured on magnetic resonance imaging (MRI) rather than computed tomography (CT) data. For all structures, increasing the number of atlases did not consistently improve accuracy. ABAS-generated contours are clinically useful for a range of structures in the male pelvis. Clinically appropriate volumes were created, but editing of some contours was inevitably required. The ideal number of atlases to improve generated automatic contours is yet to be determined.

  3. Clinical Utility of the Modified Segmental Boost Technique for Treatment of the Pelvis and Inguinal Nodes

    SciTech Connect (OSTI)

    Moran, M.S.; Castrucci, W.A.; Ahmad, M.; Song, H.; Lund, M.W.; Mani, S.; Chamberlain, Daniel; Higgins, S.A.

    2010-03-15

    Purpose: Low-lying pelvic malignancies often require simultaneous radiation to pelvis and inguinal nodes. We previously reported improved homogeneity with the modified segmental boost technique (MSBT) compared to that with traditional methods, using phantom models. Here we report our institutional clinical experience with MSBT. Methods and Materials: MSBT patients from May 2001 to March 2007 were evaluated. Parameters analyzed included isocenter/multileaf collimation shifts, time per fraction (four fields), monitor units (MU)/fraction, femoral doses, maximal dose relative to body mass index, and inguinal node depth. In addition, a dosimetric comparison of the MSBT versus intensity modulated radiation therapy (IMRT) was conducted. Results: Of the 37 MSBT patients identified, 32 were evaluable. Port film adjustments were required in 6% of films. Median values for each analyzed parameter were as follows: MU/fraction, 298 (range, 226-348); delivery time, 4 minutes; inguinal depth, 4.5 cm; volume receiving 45 Gy (V45), 7%; V27.5, 87%; body mass index, 25 (range, 16.0-33.8). Inguinal dose was 100% in all cases; in-field inhomogeneity ranged from 111% to 118%. IMRT resulted in significantly decreased dose to normal tissue but required more time for treatment planning and a higher number of MUs (1,184 vs. 313 MU). Conclusions: In our clinical experience, the mono-isocentric MSBT provides a high degree of accuracy, improved homogeneity compared with traditional techniques, ease of simulation, treatment planning, treatment delivery, and acceptable femoral doses for pelvic/inguinal radiation fields requiring 45 to 50.4 Gy. In addition, the MSBT delivers a relatively uniform dose distribution throughout the treatment volume, despite varying body habitus. Clinical scenarios for the use of MSBT vs. intensity-modulated radiation therapy are discussed. To our knowledge, this is the first study reporting the utility of MSBT in the clinical setting.

  4. Muscle segment homeobox genes direct embryonic diapause by limiting inflammation in the uterus

    SciTech Connect (OSTI)

    Cha, Jeeyeon; Burnum-Johnson, Kristin E.; Bartos, Amanda; Li, Yingju; Baker, Erin Shammel; Tilton, Susan C.; Webb-Robertson, Bobbie-Jo M.; Piehowski, Paul D.; Monroe, Matthew E.; Jegga, Anil; Murata, Shigeo; Hirota, Yasushi; Dey, Sudhansu K.

    2015-06-11

    Embryonic diapause (delayed implantation) is a reproductive strategy widespread in the animal kingdom. Under this condition, embryos at the blastocyst stage become dormant simultaneously with uterine quiescence until environmental or physiological conditions are favorable for the survival of the mother and newborn. Under favorable conditions, activation of the blastocyst and uterus ensues with implantation and progression of pregnancy. Although endocrine factors are known to participate in this process, the underlying molecular mechanism coordinating this phenomenon is not clearly understood. We recently found that uterine muscle segment homeobox (Msx) transcription factors are critical for the initiation and maintenance of delayed implantation in mice. To better understand why Msx genes are critical for delayed implantation, we compared uterine proteomics profiles between littermate floxed (Msx1/Msx2f/f) mice and mice with uterine deletion of Msx genes (Msx1/Msx2d/d) under delayed conditions. In Msx1/Msx2d/d uteri, pathways including protein translation, ubiquitin-proteasome system, inflammation, chaperone-mediated protein folding, and endoplasmic reticulum (ER) stress were enriched, and computational modeling showed intersection of these pathways on inflammatory responses. Indeed, increases in the ubiquitin-proteasome system and inflammation conformed to proteotoxic and ER stress in Msx1/Msx2d/d uteri under delayed conditions. Interestingly, treatment with a proteasome inhibitor bortezomib further exacerbated ER stress in Msx1/Msx2d/d uteri with aggravated inflammatory response, deteriorating rate of blastocyst recovery and failure to sustain delayed implantation. This study highlights a previously unrecognized role for Msx in preventing proteotoxic stress and inflammatory responses to coordinate embryo dormancy and uterine quiescence during embryonic diapause.

  5. Inter-slice bidirectional registration-based segmentation of the prostate gland in MR and CT image sequences

    SciTech Connect (OSTI)

    Khalvati, Farzad Tizhoosh, Hamid R.; Salmanpour, Aryan; Rahnamayan, Shahryar; Rodrigues, George

    2013-12-15

    Purpose: Accurate segmentation and volume estimation of the prostate gland in magnetic resonance (MR) and computed tomography (CT) images are necessary steps in diagnosis, treatment, and monitoring of prostate cancer. This paper presents an algorithm for the prostate gland volume estimation based on the semiautomated segmentation of individual slices in T2-weighted MR and CT image sequences. Methods: The proposedInter-Slice Bidirectional Registration-based Segmentation (iBRS) algorithm relies on interslice image registration of volume data to segment the prostate gland without the use of an anatomical atlas. It requires the user to mark only three slices in a given volume dataset, i.e., the first, middle, and last slices. Next, the proposed algorithm uses a registration algorithm to autosegment the remaining slices. We conducted comprehensive experiments to measure the performance of the proposed algorithm using three registration methods (i.e., rigid, affine, and nonrigid techniques). Results: The results with the proposed technique were compared with manual marking using prostate MR and CT images from 117 patients. Manual marking was performed by an expert user for all 117 patients. The median accuracies for individual slices measured using the Dice similarity coefficient (DSC) were 92% and 91% for MR and CT images, respectively. The iBRS algorithm was also evaluated regarding user variability, which confirmed that the algorithm was robust to interuser variability when marking the prostate gland. Conclusions: The proposed algorithm exploits the interslice data redundancy of the images in a volume dataset of MR and CT images and eliminates the need for an atlas, minimizing the computational cost while producing highly accurate results which are robust to interuser variability.

  6. THE BLUE STRAGGLER STAR POPULATION IN NGC1261: EVIDENCE FOR A POST-CORE-COLLAPSE BOUNCE STATE

    SciTech Connect (OSTI)

    Simunovic, Mirko; Puzia, Thomas H.; Sills, Alison E-mail: tpuzia@astro.puc.cl

    2014-11-01

    We present a multi-passband photometric study of the Blue Straggler Star (BSS) population in the Galactic globular cluster (GC) NGC1261, using available space- and ground-based survey data. The inner BSS population is found to have two distinct sequences in the color-magnitude diagram (CMD), similar to double BSS sequences detected in other GCs. These well defined sequences are presumably linked to single short-lived events such as core collapse, which are expected to boost the formation of BSSs. In agreement with this, we find a BSS sequence in NGC1261 which can be well reproduced individually by a theoretical model prediction of a 2 Gyr old population of stellar collision products, which are expected to form in the denser inner regions during short-lived core contraction phases. Additionally, we report the occurrence of a group of BSSs with unusually blue colors in the CMD, which are consistent with a corresponding model of a 200Myr old population of stellar collision products. The properties of the NGC1261 BSS populations, including their spatial distributions, suggest an advanced dynamical evolutionary state of the cluster, but the core of this GC does not show the classical signatures of core collapse. We argue that these apparent contradictions provide evidence for a post-core-collapse bounce state seen in dynamical simulations of old GCs.

  7. A segmented multi-loop antenna for selective excitation of azimuthal mode number in a helicon plasma source

    SciTech Connect (OSTI)

    Shinohara, S.; Tanikawa, T.; Motomura, T.

    2014-09-15

    A flat type, segmented multi-loop antenna was developed in the Tokai Helicon Device, built for producing high-density helicon plasma, with a diameter of 20 cm and an axial length of 100 cm. This antenna, composed of azimuthally splitting segments located on four different radial positions, i.e., r = 2.8, 4.8, 6.8, and 8.8 cm, can excite the azimuthal mode number m of 0, 1, and 2 by a proper choice of antenna feeder parts just on the rear side of the antenna. Power dependencies of the electron density n{sub e} were investigated with a radio frequency (rf) power less than 3 kW (excitation frequency ranged from 8 to 20 MHz) by the use of various types of antenna segments, and n{sub e} up to ?5 10{sup 12} cm{sup ?3} was obtained after the density jump from inductively coupled plasma to helicon discharges. Radial density profiles of m = 0 and 1 modes with low and high rf powers were measured. For the cases of these modes after the density jump, the excited mode structures derived from the magnetic probe measurements were consistent with those expected from theory on helicon waves excited in the plasma.

  8. Application of modern-control-design methodologies to a multi-segmented deformable-mirror system. Master's thesis

    SciTech Connect (OSTI)

    Vaughan, E.M.

    1991-05-23

    The multi-segmented deformable mirror system is proposed as an element for a portion of a ballistic missile defense system. The size of the mirror required for this defense function requires that the mirror be developed in segments, and then these segments should be phased together to produce one continuous, large optic. The application of multivariable control system synthesis techniques to provide closed-loop wavefront control of the deformable mirror system is the problem discussed in this thesis. The method of H at infinity control system synthesis using loop-shaping techniques was used to develop a controller that meets a robust performance specification. The number and location of sensors was treated as a design variable, and the structured singular value (mu) was used to determine the performance robustness of the deformable mirror system. Decentralized control issues are also addressed through the use of necessary conditions in an effort to determine a suitable decentralized control structure with performance similar to that of the centralized controller.

  9. Bacterial Population Genetics in a Forensic Context

    SciTech Connect (OSTI)

    Velsko, S P

    2009-11-02

    This report addresses the recent Department of Homeland Security (DHS) call for a Phase I study to (1) assess gaps in the forensically relevant knowledge about the population genetics of eight bacterial agents of concern, (2) formulate a technical roadmap to address those gaps, and (3) identify new bioinformatics tools that would be necessary to analyze and interpret population genetic data in a forensic context. The eight organisms that were studied are B. anthracis, Y. pestis, F. tularensis, Brucella spp., E. coli O157/H7, Burkholderia mallei, Burkholderia pseudomallei, and C. botulinum. Our study focused on the use of bacterial population genetics by forensic investigators to test hypotheses about the possible provenance of an agent that was used in a crime or act of terrorism. Just as human population genetics underpins the calculations of match probabilities for human DNA evidence, bacterial population genetics determines the level of support that microbial DNA evidence provides for or against certain well-defined hypotheses about the origins of an infecting strain. Our key findings are: (1) Bacterial population genetics is critical for answering certain types of questions in a probabilistic manner, akin (but not identical) to 'match probabilities' in DNA forensics. (2) A basic theoretical framework for calculating likelihood ratios or posterior probabilities for forensic hypotheses based on microbial genetic comparisons has been formulated. This 'inference-on-networks' framework has deep but simple connections to the population genetics of mtDNA and Y-STRs in human DNA forensics. (3) The 'phylogeographic' approach to identifying microbial sources is not an adequate basis for understanding bacterial population genetics in a forensic context, and has limited utility, even for generating 'leads' with respect to strain origin. (4) A collection of genotyped isolates obtained opportunistically from international locations augmented by phylogenetic representations

  10. Thermodynamic Database Population Software (DBCreate) - Energy Innovation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Portal Geothermal Geothermal Energy Analysis Energy Analysis Find More Like This Return to Search Thermodynamic Database Population Software (DBCreate) DOE Grant Recipients Contact GRANT About This Technology <span id="Caption"><span id="ctl00_MainContentHolder_zoomimage_defaultCaption">Geochemical modeling relies on accurate and up to date thermodynamic databases.</span></span> Geochemical modeling relies on accurate and up to date thermodynamic

  11. Obstacle to populating the string theory landscape

    SciTech Connect (OSTI)

    Johnson, Matthew C; Larfors, Magdalena

    2008-12-15

    We construct domain walls and instantons in a class of models with coupled scalar fields, determining, in agreement with previous studies, that many such solutions contain naked timelike singularities. Vacuum bubble solutions of this type do not contain a region of true vacuum, obstructing the ability of eternal inflation to populate other vacua. We determine a criterion that potentials must satisfy to avoid the existence of such singularities and show that many domain wall solutions in type IIB string theory are singular.

  12. Nanochannel-Directed Growth of One-Dimensional Multi-Segment Heterojunctions of Metallic Au1-xGex and Semiconducting Ge

    SciTech Connect (OSTI)

    Li, Xiangdong; Meng, Guowen; Qin, Shengyong; Xu, Qiaoling; Chu, Zhaoqin; Zhu, Xiaoguang; Kong, Mingguang; Li, An-Ping

    2012-01-01

    We report on the synthesis of multi-segment nanowire (NW) junctions of Au{sub 1-x}Ge{sub x} and Ge inside the nanochannels of porous anodic aluminum oxide template. The one-dimensional heterostructures are grown with a low-temperature chemical vapor deposition process, assisted by electrodeposited Au nanowires (AuNWs). The Au-catalyzed vapor-liquid-solid growth process occurs simultaneously in multiple locations along the nanochannel, which leads to multi-segment Au{sub 1-x}Ge{sub x}/Ge heterojunctions. The structures of the as-grown hybrid NWs, analyzed by using transmission electron microscopy and energy-dispersive X-ray spectroscopy elemental mapping, show clear compositional modulation with variable modulation period and controllable junction numbers. Remarkably, both GeNW and Au{sub 1-x}Ge{sub x}NW segments are single crystalline with abrupt interfaces and good crystallographic coherences. The electronic and transport properties of individual NW junctions are measured by using a multi-probe scanning tunneling microscope, which confirms the semiconducting nature of Ge segments and the metallic behavior of Au{sub 1-x}Ge{sub x} segments, respectively. The high yield of multiple segment NW junctions of a metal-semiconductor can facilitate the applications in nanoelectronics and optoelectronics that harness multiple functionalities of heterointerfaces.

  13. Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses

    SciTech Connect (OSTI)

    Dong, Na; Zhu, Yongqun; Lu, Qiuhe; Hu, Liyan; Zheng, Yuqing; Shao, Feng

    2012-10-10

    Rab GTPases are frequent targets of vacuole-living bacterial pathogens for appropriate trafficking of the vacuole. Here we discover that bacterial effectors including VirA from nonvacuole Shigella flexneri and EspG from extracellular Enteropathogenic Escherichia coli (EPEC) harbor TBC-like dual-finger motifs and exhibits potent RabGAP activities. Specific inactivation of Rab1 by VirA/EspG disrupts ER-to-Golgi trafficking. S. flexneri intracellular persistence requires VirA TBC-like GAP activity that mediates bacterial escape from autophagy-mediated host defense. Rab1 inactivation by EspG severely blocks host secretory pathway, resulting in inhibited interleukin-8 secretion from infected cells. Crystal structures of VirA/EspG-Rab1-GDP-aluminum fluoride complexes highlight TBC-like catalytic role for the arginine and glutamine finger residues and reveal a 3D architecture distinct from that of the TBC domain. Structure of Arf6-EspG-Rab1 ternary complex illustrates a pathogenic signaling complex that rewires host Arf signaling to Rab1 inactivation. Structural distinctions of VirA/EspG further predict a possible extensive presence of TBC-like RabGAP effectors in counteracting various host defenses.

  14. The reionization of galactic satellite populations

    SciTech Connect (OSTI)

    Ocvirk, P.; Gillet, N.; Aubert, D.; Chardin, J.; Knebe, A.; Yepes, G.; Libeskind, N.; Gottlöber, S.; Hoffman, Y.

    2014-10-10

    We use high-resolution simulations of the formation of the local group, post-processed by a radiative transfer code for UV photons, to investigate the reionization of the satellite populations of an isolated Milky Way-M31 galaxy pair in a variety of scenarios. We use an improved version of ATON which includes a simple recipe for radiative feedback. In our baseline models, reionization is initiated by low-mass, radiatively regulated halos at high redshift, until more massive halos appear, which then dominate and complete the reionization process. We investigate the relation between reionization history and present-day positions of the satellite population. We find that the average reionization redshift (z {sub r}) of satellites is higher near galaxy centers (MW and M31). This is due to the inside out reionization patterns imprinted by massive halos within the progenitor during the epoch of reionization, which end up forming the center of the galaxy. Due to incomplete dynamical mixing during galaxy assembly, these early patterns survive to present day, resulting in a clear radial gradient in the average satellite reionization redshift, up to the virial radius of MW and M31 and beyond. In the lowest emissivity scenario, the outer satellites are reionized about 180 Myr later than the inner satellites. This delay decreases with increasing source model emissivity, or in the case of external reionization by Virgo or M31, because reionization occurs faster overall and becomes spatially quasi-uniform at the highest emissivity.

  15. A Population Health Model for Integrated Assessment Models

    SciTech Connect (OSTI)

    Pitcher, Hugh M.; Ebi, Kristie L.; Brenkert, Antoinette L.

    2008-05-01

    This paper presents the initial results of a project to develop a population health model so we can extend the scenarios included in the IPCC's Special Report on Emissions Scenarios to include population health status.

  16. Automated fibroglandular tissue segmentation and volumetric density estimation in breast MRI using an atlas-aided fuzzy C-means method

    SciTech Connect (OSTI)

    Wu, Shandong; Weinstein, Susan P.; Conant, Emily F.; Kontos, Despina

    2013-12-15

    Purpose: Breast magnetic resonance imaging (MRI) plays an important role in the clinical management of breast cancer. Studies suggest that the relative amount of fibroglandular (i.e., dense) tissue in the breast as quantified in MR images can be predictive of the risk for developing breast cancer, especially for high-risk women. Automated segmentation of the fibroglandular tissue and volumetric density estimation in breast MRI could therefore be useful for breast cancer risk assessment. Methods: In this work the authors develop and validate a fully automated segmentation algorithm, namely, an atlas-aided fuzzy C-means (FCM-Atlas) method, to estimate the volumetric amount of fibroglandular tissue in breast MRI. The FCM-Atlas is a 2D segmentation method working on a slice-by-slice basis. FCM clustering is first applied to the intensity space of each 2D MR slice to produce an initial voxelwise likelihood map of fibroglandular tissue. Then a prior learned fibroglandular tissue likelihood atlas is incorporated to refine the initial FCM likelihood map to achieve enhanced segmentation, from which the absolute volume of the fibroglandular tissue (|FGT|) and the relative amount (i.e., percentage) of the |FGT| relative to the whole breast volume (FGT%) are computed. The authors' method is evaluated by a representative dataset of 60 3D bilateral breast MRI scans (120 breasts) that span the full breast density range of the American College of Radiology Breast Imaging Reporting and Data System. The automated segmentation is compared to manual segmentation obtained by two experienced breast imaging radiologists. Segmentation performance is assessed by linear regression, Pearson's correlation coefficients, Student's pairedt-test, and Dice's similarity coefficients (DSC). Results: The inter-reader correlation is 0.97 for FGT% and 0.95 for |FGT|. When compared to the average of the two readers manual segmentation, the proposed FCM-Atlas method achieves a correlation ofr = 0.92 for

  17. Distinct photoluminescence and Raman spectroscopy signatures for identifying highly crystalline WS2 monolayers produced by different growth methods

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    McCreary, Amber; Berkdemir, Ayse; Wang, Junjie; Nguyen, Minh An; Elías, Ana Laura; Perea-López, Néstor; Fujisawa, Kazunori; Kabius, Bernd; Carozo, Victor; Cullen, David A.; et al

    2016-03-08

    We report that transition metal dichalcogenides (TMDs) such as WS2 show exciting promise in electronic and optoelectronic applications. Significant variations in the transport, Raman, and photoluminescence (PL) can be found in the literature, yet it is rarely addressed why this is. In this report, Raman and PL of monolayered WS2 produced via different methods are studied and distinct features that indicate the degree of crystallinity of the material are observed. While the intensity of the LA(M) Raman mode is found to be a useful indicator to assess the crystallinity, PL is drastically more sensitive to the quality of the materialmore » than Raman spectroscopy. We also show that even exfoliated crystals, which are usually regarded as the most pristine material, can contain large amounts of defects that would not be apparent without Raman and PL measurements. Ultimately, these findings can be applied to the understanding of other two-dimensional heterostructured systems.« less

  18. Population Sensitivity Evaluation of Two Candidate Locations for Possible

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Small Modular Reactor Siting | Department of Energy Population Sensitivity Evaluation of Two Candidate Locations for Possible Small Modular Reactor Siting Population Sensitivity Evaluation of Two Candidate Locations for Possible Small Modular Reactor Siting This report documents population density studies of selected sites in the Hampton Roads, Virginia area. Population Sensitivity Evaluation of Two Candidate Locations for Possible Small Modular Reactor Siting (3.84 MB) More Documents &

  19. The Other 15%: Expanding Energy Efficiency to Rural Populations

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Efficiency Discussion Are there other examples of successful residential energy efficiency program implementation in rural populations? What energy efficiency ...

  20. Executive Order 12898: Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations (1994)

    Broader source: Energy.gov [DOE]

    Executive Order 12898: Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations (1994).  Directs each federal agency to make environmental justice part of...

  1. Source and seed populations for relativistic electrons: Their roles in radiation belt changes

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Jaynes, A. N.; Baker, D. N.; Singer, H. J.; Rodriguez, J. V.; Loto'aniu, T. M.; Ali, A. F.; Elkington, S. R.; Li, X.; Kanekal, S. G.; Claudepierre, S. G.; et al

    2015-09-09

    Strong enhancements of outer Van Allen belt electrons have been shown to have a clear dependence on solar wind speed and on the duration of southward interplanetary magnetic field. However, individual case study analyses also have demonstrated that many geomagnetic storms produce little in the way of outer belt enhancements and, in fact, may produce substantial losses of relativistic electrons. In this study, focused upon a key period in August–September 2014, we use GOES geostationary orbit electron flux data and Van Allen Probes particle and fields data to study the process of radiation belt electron acceleration. One particular interval, 13–22more » September, initiated by a short-lived geomagnetic storm and characterized by a long period of primarily northward interplanetary magnetic field (IMF), showed strong depletion of relativistic electrons (including an unprecedented observation of long-lasting depletion at geostationary orbit) while an immediately preceding, and another immediately subsequent, storm showed strong radiation belt enhancement. We demonstrate with these data that two distinct electron populations resulting from magnetospheric substorm activity are crucial elements in the ultimate acceleration of highly relativistic electrons in the outer belt: the source population (tens of keV) that give rise to VLF wave growth and the seed population (hundreds of keV) that are, in turn, accelerated through VLF wave interactions to much higher energies. ULF waves may also play a role by either inhibiting or enhancing this process through radial diffusion effects. Furthermore, if any components of the inner magnetospheric accelerator happen to be absent, the relativistic radiation belt enhancement fails to materialize.« less

  2. Source and seed populations for relativistic electrons: Their roles in radiation belt changes

    SciTech Connect (OSTI)

    Jaynes, A. N.; Baker, D. N.; Singer, H. J.; Rodriguez, J. V.; Loto'aniu, T. M.; Ali, A. F.; Elkington, S. R.; Li, X.; Kanekal, S. G.; Claudepierre, S. G.; Fennell, J. F.; Li, W.; Thorne, R. M.; Kletzing, C. A.; Spence, H. E.; Reeves, G. D.

    2015-09-09

    Strong enhancements of outer Van Allen belt electrons have been shown to have a clear dependence on solar wind speed and on the duration of southward interplanetary magnetic field. However, individual case study analyses also have demonstrated that many geomagnetic storms produce little in the way of outer belt enhancements and, in fact, may produce substantial losses of relativistic electrons. In this study, focused upon a key period in August–September 2014, we use GOES geostationary orbit electron flux data and Van Allen Probes particle and fields data to study the process of radiation belt electron acceleration. One particular interval, 13–22 September, initiated by a short-lived geomagnetic storm and characterized by a long period of primarily northward interplanetary magnetic field (IMF), showed strong depletion of relativistic electrons (including an unprecedented observation of long-lasting depletion at geostationary orbit) while an immediately preceding, and another immediately subsequent, storm showed strong radiation belt enhancement. We demonstrate with these data that two distinct electron populations resulting from magnetospheric substorm activity are crucial elements in the ultimate acceleration of highly relativistic electrons in the outer belt: the source population (tens of keV) that give rise to VLF wave growth and the seed population (hundreds of keV) that are, in turn, accelerated through VLF wave interactions to much higher energies. ULF waves may also play a role by either inhibiting or enhancing this process through radial diffusion effects. Furthermore, if any components of the inner magnetospheric accelerator happen to be absent, the relativistic radiation belt enhancement fails to materialize.

  3. Source and seed populations for relativistic electrons: Their roles in radiation belt changes

    SciTech Connect (OSTI)

    Jaynes, A. N.; Baker, D. N.; Singer, H. J.; Rodriguez, J. V.; Loto'aniu, T. M.; Ali, A. F.; Elkington, S. R.; Li, X.; Kanekal, S. G.; Claudepierre, S. G.; Fennell, J. F.; Li, W.; Thorne, R. M.; Kletzing, C. A.; Spence, H. E.; Reeves, G. D.

    2015-09-09

    Strong enhancements of outer Van Allen belt electrons have been shown to have a clear dependence on solar wind speed and on the duration of southward interplanetary magnetic field. However, individual case study analyses also have demonstrated that many geomagnetic storms produce little in the way of outer belt enhancements and, in fact, may produce substantial losses of relativistic electrons. In this study, focused upon a key period in AugustSeptember 2014, we use GOES geostationary orbit electron flux data and Van Allen Probes particle and fields data to study the process of radiation belt electron acceleration. One particular interval, 1322 September, initiated by a short-lived geomagnetic storm and characterized by a long period of primarily northward interplanetary magnetic field (IMF), showed strong depletion of relativistic electrons (including an unprecedented observation of long-lasting depletion at geostationary orbit) while an immediately preceding, and another immediately subsequent, storm showed strong radiation belt enhancement. We demonstrate with these data that two distinct electron populations resulting from magnetospheric substorm activity are crucial elements in the ultimate acceleration of highly relativistic electrons in the outer belt: the source population (tens of keV) that give rise to VLF wave growth and the seed population (hundreds of keV) that are, in turn, accelerated through VLF wave interactions to much higher energies. ULF waves may also play a role by either inhibiting or enhancing this process through radial diffusion effects. Furthermore, if any components of the inner magnetospheric accelerator happen to be absent, the relativistic radiation belt enhancement fails to materialize.

  4. SU-E-I-71: Quality Assessment of Surrogate Metrics in Multi-Atlas-Based Image Segmentation

    SciTech Connect (OSTI)

    Zhao, T; Ruan, D

    2015-06-15

    Purpose: With the ever-growing data of heterogeneous quality, relevance assessment of atlases becomes increasingly critical for multi-atlas-based image segmentation. However, there is no universally recognized best relevance metric and even a standard to compare amongst candidates remains elusive. This study, for the first time, designs a quantification to assess relevance metrics’ quality, based on a novel perspective of the metric as surrogate for inferring the inaccessible oracle geometric agreement. Methods: We first develop an inference model to relate surrogate metrics in image space to the underlying oracle relevance metric in segmentation label space, with a monotonically non-decreasing function subject to random perturbations. Subsequently, we investigate model parameters to reveal key contributing factors to surrogates’ ability in prognosticating the oracle relevance value, for the specific task of atlas selection. Finally, we design an effective contract-to-noise ratio (eCNR) to quantify surrogates’ quality based on insights from these analyses and empirical observations. Results: The inference model was specialized to a linear function with normally distributed perturbations, with surrogate metric exemplified by several widely-used image similarity metrics, i.e., MSD/NCC/(N)MI. Surrogates’ behaviors in selecting the most relevant atlases were assessed under varying eCNR, showing that surrogates with high eCNR dominated those with low eCNR in retaining the most relevant atlases. In an end-to-end validation, NCC/(N)MI with eCNR of 0.12 compared to MSD with eCNR of 0.10 resulted in statistically better segmentation with mean DSC of about 0.85 and the first and third quartiles of (0.83, 0.89), compared to MSD with mean DSC of 0.84 and the first and third quartiles of (0.81, 0.89). Conclusion: The designed eCNR is capable of characterizing surrogate metrics’ quality in prognosticating the oracle relevance value. It has been demonstrated to be

  5. Magnetic Fields in Population III Star Formation

    SciTech Connect (OSTI)

    Turk, Matthew J.; Oishi, Jeffrey S.; Abel, Tom; Bryan, Greg

    2012-02-22

    We study the buildup of magnetic fields during the formation of Population III star-forming regions, by conducting cosmological simulations from realistic initial conditions and varying the Jeans resolution. To investigate this in detail, we start simulations from identical initial conditions, mandating 16, 32 and 64 zones per Jeans length, and studied the variation in their magnetic field amplification. We find that, while compression results in some amplification, turbulent velocity fluctuations driven by the collapse can further amplify an initially weak seed field via dynamo action, provided there is sufficient numerical resolution to capture vortical motions (we find this requirement to be 64 zones per Jeans length, slightly larger than, but consistent with previous work run with more idealized collapse scenarios). We explore saturation of amplification of the magnetic field, which could potentially become dynamically important in subsequent, fully-resolved calculations. We have also identified a relatively surprising phenomena that is purely hydrodynamic: the higher-resolved simulations possess substantially different characteristics, including higher infall-velocity, increased temperatures inside 1000 AU, and decreased molecular hydrogen content in the innermost region. Furthermore, we find that disk formation is suppressed in higher-resolution calculations, at least at the times that we can follow the calculation. We discuss the effect this may have on the buildup of disks over the accretion history of the first clump to form as well as the potential for gravitational instabilities to develop and induce fragmentation.

  6. Longwall population holds steady at 52

    SciTech Connect (OSTI)

    Fiscor, S.

    2007-02-15

    The overall population stands at 48 mines operating 53 longwalls. CONSOL Energy remains the leading US longwall operator with 12 installations. With the acquisition of the Andalex properties in Utah, Robert E Murray now owns eight longwall mines followed by Arch Coal (5) and Massey Energy (4). West Virginia remains the leading longwall mining state with 14 faces in 2005, followed by Pennsylvania (8), Alabama (6), Utah (6) and Colorado (5). A detailed table gives for each longwall installation, the ownership, seam height, cutting height, panel width and length, overburden, number of gate entries, depth of cut, model of equipment used (shearer, haulage system, roof support, face conveyor, stage loader, crusher, electrical controls and voltage to face). The most striking difference between the 2007 US Longwall Census and past reports carried out by Coal Age is the increased number of longwall operators that believe they have the most productive operation. Several operators have purchased or intend to purchase new equipment or upgrade the technology of the faces. Longwall mining in the US has reached a balanced state. 1 photo., 1 tab.

  7. Distinct effects of anthropogenic aerosols on the East Asian summer monsoon between multidecadal strong and weak monsoon stages

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xie, Xiaoning; Wang, Hongli; Liu, Xiaodong; Li, Jiandong; Wang, Zhaosheng; Liu, Yangang

    2016-06-18

    Industrial emissions of anthropogenic aerosols over East Asia have greatly increased in recent decades, and so the interactions between atmospheric aerosols and the East Asian summer monsoon (EASM) have attracted enormous attention. In order to further understand the aerosol-EASM interaction, we investigate the impacts of anthropogenic aerosols on the EASM during the multidecadal strong (1950–1977) and weak (1978–2000) EASM stages using the Community Atmospheric Model 5.1. Numerical experiments are conducted for the whole period, including the two different EASM stages, with present day (PD, year 2000) and preindustrial (PI, year 1850) aerosol emissions, as well as the observed time-varying aerosolmore » emissions. A comparison of the results from PD and PI shows that, with the increase in anthropogenic aerosols, the large-scale EASM intensity is weakened to a greater degree (-9.8%) during the weak EASM stage compared with the strong EASM stage (-4.4%). The increased anthropogenic aerosols also result in a significant reduction in precipitation over North China during the weak EASM stage, as opposed to a statistically insignificant change during the strong EASM stage. Because of greater aerosol loading and the larger sensitivity of the climate system during weak EASM stages, the aerosol effects are more significant during these EASM stages. Moreover, these results suggest that anthropogenic aerosols from the same aerosol emissions have distinct effects on the EASM and the associated precipitation between the multidecadal weak and strong EASM stages.« less

  8. Distinctive plume formation in atmospheric Ar and He plasmas in microwave frequency band and suitability for biomedical applications

    SciTech Connect (OSTI)

    Lee, H. Wk.; Kang, S. K.; Won, I. H.; Kim, H. Y.; Kwon, H. C.; Sim, J. Y.; Lee, J. K.

    2013-12-15

    Distinctive discharge formation in atmospheric Ar and He plasmas was observed in the microwave frequency band using coaxial transmission line resonators. Ar plasmas formed a plasma plume whereas He formed only confined plasmas. As the frequency increased from 0.9 GHz to 2.45 GHz, the Ar plasma exhibited contraction and filamentation, and the He plasmas were constricted. Various powers and gas flow rates were applied to identify the effect of the electric field and gas flow rate on plasma plume formation. The He plasmas were more strongly affected by the electric field than the Ar plasmas. The breakdown and sustain powers yielded opposite results from those for low-frequency plasmas (?kHz). The phenomena could be explained by a change in the dominant ionization process with increasing frequency. Penning ionization and the contribution of secondary electrons in sheath region reduced as the frequency increased, leading to less efficient ionization of He because its ionization and excitation energies are higher than those of Ar. The emission spectra showed an increase in the NO and N{sub 2} second positive band in both the Ar and He plasmas with increasing frequency whereas the hydroxyl radical and atomic O peaks did not increase with increasing frequency but were highest at particular frequencies. Further, the frequency effect of properties such as the plasma impedance, electron density, and device efficiency were presented. The study is expected to be helpful for determining the optimal conditions of plasma systems for biomedical applications.

  9. Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

    SciTech Connect (OSTI)

    Kwon, Hyock Joo; Abi-Mosleh, Lina; Wang, Michael L.; Deisenhofer, Johann; Goldstein, Joseph L.; Brown, Michael S.; Infante, Rodney E.

    2010-09-21

    LDL delivers cholesterol to lysosomes by receptor-mediated endocytosis. Exit of cholesterol from lysosomes requires two proteins, membrane-bound Niemann-Pick C1 (NPC1) and soluble NPC2. NPC2 binds cholesterol with its isooctyl side chain buried and its 3{beta}-hydroxyl exposed. Here, we describe high-resolution structures of the N-terminal domain (NTD) of NPC1 and complexes with cholesterol and 25-hydroxycholesterol. NPC1(NTD) binds cholesterol in an orientation opposite to NPC2: 3{beta}-hydroxyl buried and isooctyl side chain exposed. Cholesterol transfer from NPC2 to NPC1(NTD) requires reorientation of a helical subdomain in NPC1(NTD), enlarging the opening for cholesterol entry. NPC1 with point mutations in this subdomain (distinct from the binding subdomain) cannot accept cholesterol from NPC2 and cannot restore cholesterol exit from lysosomes in NPC1-deficient cells. We propose a working model wherein after lysosomal hydrolysis of LDL-cholesteryl esters, cholesterol binds NPC2, which transfers it to NPC1(NTD), reversing its orientation and allowing insertion of its isooctyl side chain into the outer lysosomal membranes.

  10. Large-scale atlas of microarray data reveals the distinct expression landscape of different tissues in Arabidopsis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    He, Fei; Maslov, Sergei; Yoo, Shinjae; Wang, Daifeng; Kumari, Sunita; Gerstein, Mark; Ware, Doreen

    2016-03-25

    Here, transcriptome datasets from thousands of samples of the model plant Arabidopsis thaliana have been collectively generated by multiple individual labs. Although integration and meta-analysis of these samples has become routine in the plant research community, it is often hampered by the lack of metadata or differences in annotation styles by different labs. In this study, we carefully selected and integrated 6,057 Arabidopsis microarray expression samples from 304 experiments deposited to NCBI GEO. Metadata such as tissue type, growth condition, and developmental stage were manually curated for each sample. We then studied global expression landscape of the integrated dataset andmore » found that samples of the same tissue tend to be more similar to each other than to samples of other tissues, even in different growth conditions or developmental stages. Root has the most distinct transcriptome compared to aerial tissues, but the transcriptome of cultured root is more similar to those of aerial tissues as the former samples lost their cellular identity. Using a simple computational classification method, we showed that the tissue type of a sample can be successfully predicted based on its expression profile, opening the door for automatic metadata extraction and facilitating re-use of plant transcriptome data. As a proof of principle we applied our automated annotation pipeline to 708 RNA-seq samples from public repositories and verified accuracy of our predictions with samples’ metadata provided by authors.« less