Sample records for disease registry atsdr

  1. Integration of site-specific health information: Agency for Toxic Substances and Disease Registry health assessments

    SciTech Connect (OSTI)

    Lesperance, A.M.; Siegel, M.R.

    1990-12-01T23:59:59.000Z

    The Agency for Toxic Substances and Disease Registry is required to conduct a health assessment of any site that is listed on or proposed for the US Environmental Protection Agency's National Priorities List. Sixteen US Department of Energy (DOE) sites currently fall into this category. Health assessments contain a qualitative description of impacts to public health and the environment from hazardous waste sites, as well as recommendations for actions to mitigate or eliminate risk. Because these recommendations may have major impacts on compliance activities at DOE facilities, the health assessments are an important source of information for the monitoring activities of DOE's Office of Environmental Compliance (OEC). This report provides an overview of the activities involved in preparing the health assessment, its role in environmental management, and its key elements.

  2. Marijuana National Forest: Encroachment on California Public Lands for Cannabis Cultivation

    E-Print Network [OSTI]

    Mallery, Mark

    2011-01-01T23:59:59.000Z

    Disease Registry - ToxFAQs™: DDT, DDE, and DDD." ATSDR Home.Disease Registry - ToxFAQs™: DDT, DDE, and DDD." ATSDR Home.Diphenyl-Trichloroethane (DDT). DDT was banned in the United

  3. National Center for Environmental Health Agency for Toxic Substances and Disease Registry

    E-Print Network [OSTI]

    to implement community- based interventions, build local coalitions, and track the impact of the disease://www.cdc.gov/asthma/stateprofiles/ Asthma_in_NYS.pdf CS247509-N #12;2 Reducing children's lead exposure is perhaps the greatest

  4. MUSCULOSKELETAL OUTCOMES REGISTRY

    E-Print Network [OSTI]

    registry is voluntary; withdrawal will not affect your medical care. Department of Orthopaedics HELP US designed to collect, manage, and analyze information on people with certain medical problems by allowing them to analyze your treatment outcomes. Major advances have been made in musculoskeletal research

  5. The International LAM Registry: A Component of an Innovative Web-Based Clinician, Researcher, and Patient-Driven Rare Disease Research Platform

    E-Print Network [OSTI]

    Nurok, Michael

    Background: A relative inability to capture a sufficiently large patient population in any one geographic location has traditionally limited research into rare diseases.

  6. DUBLIN CITY UNIVERSITY Registry Systems and Processes

    E-Print Network [OSTI]

    Humphrys, Mark

    and the conferring events. · Provide support to Registry staff on best practice for validating the accuracy (Administrator I) (Five Year Fixed Term Contract) Description of Registry The Registry is a busy and demanding office with responsibility for providing administrative support for the university and managing

  7. ORISE: REAC/TS Radiation Accident Registries

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accident Registries The Radiation Emergency Assistance CenterTraining Site (REACTS) at the Oak Ridge Institute for Science and Education (ORISE) maintains a number of radiation...

  8. North American Renewables Registry (Multiple States)

    Broader source: Energy.gov [DOE]

    The North American Renewables Registry (NAR) provides a Web-based platform trusted to create, track, and manage renewable energy certificate (REC) origination for clean generation facilities and...

  9. How information resources are used by federal agencies in risk assessment application: Rapporteur summary

    SciTech Connect (OSTI)

    Fenner-Crisp, P. [Environmental Protection Agency, Washington, DC (United States)

    1990-12-31T23:59:59.000Z

    The application of information available for risk assessment from the federal perspective is described. Different federal agencies conduct varying degrees of hazard evaluation, and some also generate empirical data. The role of the Agency for Toxic Substances and Disease Registry in hazard assessments of potential public health impacts of Superfund sites includes identification of the 275 most significant substances. ATSDR is responsible for preparing toxicological profiles. ATSDR also identifies data gaps and needs critical to adequately assessing human health impacts.

  10. Research Subject Registry: A Critical Tool for Successful Recruitment

    E-Print Network [OSTI]

    Nguyen, Danh

    -Promote awareness -- Speaking engagements #12;Volunteer Registry Metrics Healthy 40% T2D 18% HTN 16% Gout 14% Asthma

  11. United Kingdom Carotid Artery Stent Registry: Short- and Long-Term Outcomes

    SciTech Connect (OSTI)

    Goode, S. D., E-mail: s.goode@sheffield.ac.uk; Cleveland, T. J.; Gaines, P. A. [Northern General Hospital, Sheffield Vascular Institute (United Kingdom)] [Northern General Hospital, Sheffield Vascular Institute (United Kingdom)

    2013-10-15T23:59:59.000Z

    Background: Carotid artery stenting (CAS) has evolved to treat carotid artery disease with the intention of prevent stroke. The British Society of Interventional Radiologists developed a voluntary registry to monitor the practice of this novel procedure. We present the data from the United Kingdom (UK) CAS registry for short and long-term outcomes for symptomatic and asymptomatic carotid disease. Methods: The UK CAS registry collected data from 1998 to 2010 from 31 hospitals across the UK for 1,154 patients. All interventions were enrolled in the registry for both asymptomatic and symptomatic patients. Initial entry forms were completed for each patient entered with data including indications, demographic data, CAS data (including stents and protection device details) and 30-day outcomes. Complications were documented. Follow-up data were collected at yearly intervals. Results: Nine hundred fifty-three (83 %) symptomatic and 201 (17 %) asymptomatic patients were enrolled into the registry. The 30-day all stroke and death rates for symptomatic patients were 5.5 and 2.2 % for those with asymptomatic disease. The 30-day mortality rate was 1.7 % for symptomatic and 0.6 % for asymptomatic patients. For symptomatic patients undergoing CAS, the 7-year all-cause mortality rate was 22.2 % and for asymptomatic patients 18.1 %. The 7-year all-cause mortality and disabling stroke rates were 25.3 and 19.4 %, respectively. Conclusion: These data indicate that outside of the tight constraints of a randomised trial, CAS provides effective prophylaxis against stroke and death.

  12. Formaldehyde exposure and leukemia: A new meta-analysis and potential Luoping Zhang a,

    E-Print Network [OSTI]

    California at Berkeley, University of

    lymphocytic leukemia; AML, acute myeloid leukemia; ATSDR, Agency for Toxic Substances and Disease RegistryReview Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms Luoping between leukemia and occupational exposure to formaldehyde''. Here, we review the epidemiological studies

  13. action registry development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    marketed as carbon offsets. Before projects can be included in the Registry, urban forestry programs are required to attain sustainability by demonstrating no net loss of...

  14. ORISE: Worker Health Studies - Beryllium Associated Worker Registry...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Oak Ridge Institute for Science Education Beryllium Associated Worker Registry (BAWR) The Oak Ridge Institute for Science and Education (ORISE) maintains the Beryllium Associated...

  15. attack registry rationale: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    111 A Registry Service as a Foundation for Brokering Mathematical Rebhi Baraka Olga Caprotti Computer Technologies and Information Sciences Websites Summary: service...

  16. The Climate Registry | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries PvtStratosolarTharaldson Ethanol LLC Jump to: navigation, searchLookTheRegistry

  17. E-Print Network 3.0 - aids-cancer registry match Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Scalable P2P Infrastructure of Registries for Semantic Publication and Discovery of Web Services Summary: for semantic discovery of Web services in UDDI Registries....

  18. REAC/TS Radiation Accident Registry: An Overview

    SciTech Connect (OSTI)

    Doran M. Christensen, DO, REAC /TS Associate Director and Staff Physician Becky Murdock, REAC/TS Registry and Health Physics Technician

    2012-12-12T23:59:59.000Z

    Over the past four years, REAC/TS has presented a number of case reports from its Radiation Accident Registry. Victims of radiological or nuclear incidents must meet certain dose criteria for an incident to be categorized as an “accident” and be included in the registry. Although the greatest numbers of “accidents” in the United States that have been entered into the registry involve radiation devices, the greater percentage of serious accidents have involved sealed sources of one kind or another. But if one looks at the kinds of accident scenarios that have resulted in extreme consequence, i.e., death, the greater share of deaths has occurred in medical settings.

  19. angioplastiche emilia-romagna registry: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    37 A Registry Service as a Foundation for Brokering Mathematical Rebhi Baraka Olga Caprotti Computer Technologies and Information Sciences Websites Summary: service...

  20. housingreportAn e-publication of UMass Lowell and the Middlesex North Registry of Deeds Merrimack Valley

    E-Print Network [OSTI]

    Massachusetts at Lowell, University of

    Valley Volume 7, Issue 1 January 2013 A Year in Review at the Registry of Deeds on page 4 The Year in Review at the Registry of Deeds By Richard P. Howe Jr. Deeds, Mortgages

  1. Beryllium disease

    SciTech Connect (OSTI)

    Not Available

    1991-12-20T23:59:59.000Z

    After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

  2. Health physics and public health activities at hazardous wastes sites

    SciTech Connect (OSTI)

    Charp, P.A. [Agency for Toxic Substances and Disease Registry, Atlanta, GA (United States)

    1995-12-31T23:59:59.000Z

    The Agency for Toxic Substances and Disease Registry (ATSDR) has worked with the U.S. Environmental Protection Agency (EPA) at several sites contaminated with radioactive materials. The Navajo Brown Vandever (B-V) uranium mine site near Bluewater, New Mexico, and the Austin Avenue Radiation Site (AAR) in Lansdowne, Pennsylvania were the subject of ATSDR health advisories. The sites were contamined with uranium or uranium byproducts but the identification of potential health effects and actions taken to prevent or reduce exposures were approached from different perspectives. At B-V contaminants included uranium and mine tailings, radium, and radon. Contaminants at the site and physical hazards were removed. At AAR, radium and radon were located in residential settings. Residents who might have had annual exposures greater than accepted standards or recommendations were relocated and contaminated building demolished.

  3. Strong Memorial Hospital Cancer Committee Report 2 2011 Strong Memorial Hospital Cancer Registry Report

    E-Print Network [OSTI]

    Goldman, Steven A.

    's two largest cancer research facilities could result in a scientific powerhouse, enhancing faculty patients.This accounts for an accrual rate of 16.9 percent using the 2010 registry data for total number

  4. Muddy Water? Variation in Reporting Receipt of Breast Cancer Radiation Therapy by Population-Based Tumor Registries

    SciTech Connect (OSTI)

    Walker, Gary V. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Giordano, Sharon H. [Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Williams, Melanie [Texas Cancer Registry, Department of State Health Services, Austin, Texas (United States)] [Texas Cancer Registry, Department of State Health Services, Austin, Texas (United States); Jiang, Jing [Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Niu, Jiangong [Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); MacKinnon, Jill; Anderson, Patricia; Wohler, Brad [Florida Cancer Data System, University of Miami School of Medicine, Miami, Florida (United States)] [Florida Cancer Data System, University of Miami School of Medicine, Miami, Florida (United States); Sinclair, Amber H.; Boscoe, Francis P.; Schymura, Maria J. [New York State Cancer Registry, New York State Department of Health, Albany, New York (United States)] [New York State Cancer Registry, New York State Department of Health, Albany, New York (United States); Buchholz, Thomas A. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Smith, Benjamin D., E-mail: BSmith3@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-07-15T23:59:59.000Z

    Purpose: To evaluate, in the setting of breast cancer, the accuracy of registry radiation therapy (RT) coding compared with the gold standard of Medicare claims. Methods and Materials: Using Surveillance, Epidemiology, and End Results (SEER)–Medicare data, we identified 73,077 patients aged ?66 years diagnosed with breast cancer in the period 2001-2007. Underascertainment (1 - sensitivity), sensitivity, specificity, ?, and ?{sup 2} were calculated for RT receipt determined by registry data versus claims. Multivariate logistic regression characterized patient, treatment, and geographic factors associated with underascertainment of RT. Findings in the SEER–Medicare registries were compared with three non-SEER registries (Florida, New York, and Texas). Results: In the SEER–Medicare registries, 41.6% (n=30,386) of patients received RT according to registry coding, versus 49.3% (n=36,047) according to Medicare claims (P<.001). Underascertainment of RT was more likely if patients resided in a newer SEER registry (odds ratio [OR] 1.70, 95% confidence interval [CI] 1.60-1.80; P<.001), rural county (OR 1.34, 95% CI 1.21-1.48; P<.001), or if RT was delayed (OR 1.006/day, 95% CI 1.006-1.007; P<.001). Underascertainment of RT receipt in SEER registries was 18.7% (95% CI 18.6-18.8%), compared with 44.3% (95% CI 44.0-44.5%) in non-SEER registries. Conclusions: Population-based tumor registries are highly variable in ascertainment of RT receipt and should be augmented with other data sources when evaluating quality of breast cancer care. Future work should identify opportunities for the radiation oncology community to partner with registries to improve accuracy of treatment data.

  5. National Center for Environmental Health Agency for Toxic Substances and Disease Registry

    E-Print Network [OSTI]

    in the environment, such as in swamps. Paper mills, the textile industry, petroleum and natural gas extraction of drywall produced in China. State and local health authorities also received similar reports. At this time. Label: Can you see the back side of your drywall? Some drywall from China is stamped with"Made in China

  6. National Center for Environmental Health Agency for Toxic Substances and Disease Registry

    E-Print Network [OSTI]

    capacity to help identify children with dangerous exposure to lead. · Connect these families and children's National Center for Environmental Health: Maryland CDC 24/7: Saving Lives. Protecting People from Health Threats. Saving Money through Prevention. Environmental Health Your environment is everything around you

  7. National Center for Environmental Health Agency for Toxic Substances and Disease Registry

    E-Print Network [OSTI]

    , and technical capacity to help identify children with dangerous exposure to lead. · Connect families's National Center for Environmental Health: California CDC 24/7: Saving Lives. Protecting People from Health Threats. Saving Money through Prevention. Environmental Health Your environment is everything around you

  8. National Center for Environmental Health Agency for Toxic Substances and Disease Registry

    E-Print Network [OSTI]

    to lead. · Connect these families and children to appropriate healthcare and case management. · Inspect's National Center for Environmental Health: Montana CDC 24/7: Saving Lives. Protecting People from Health Threats. Saving Money through Prevention. Environmental Health Your environment is everything around you

  9. National Center for Environmental Health Agency for Toxic Substances and Disease Registry

    E-Print Network [OSTI]

    with dangerous exposures to lead. · Connect these families and children to appropriate healthcare and case's National Center for Environmental Health: Illinois CDC 24/7: Saving Lives. Protecting People from Health Threats. Saving Money through Prevention. Environmental Health Your environment is everything around you

  10. National Center for Environmental Health Agency for Toxic Substances and Disease Registry

    E-Print Network [OSTI]

    capacity to help identify children with dangerous exposures to lead. · Connect these families and children's National Center for Environmental Health: Louisiana CDC 24/7: Saving Lives. Protecting People from Health Threats. Saving Money through Prevention. Environmental Health Your environment is everything around you

  11. National Center for Environmental Health Agency for Toxic Substances and Disease Registry

    E-Print Network [OSTI]

    capacity to help identify children with dangerous exposure to lead. · Connect these families and children's National Center for Environmental Health: Connecticut CDC 24/7: Saving Lives. Protecting People from Health Threats. Saving Money through Prevention. Environmental Health Your environment is everything around you

  12. For information on current fee levels, see: www.strath.ac.uk/registry/students/finance

    E-Print Network [OSTI]

    Mottram, Nigel

    Fees For information on current fee levels, see: www.strath.ac.uk/registry/students/finance How Enquiries can be made to either of the following in the Department of Accounting & Finance: Professor Dick Davies Course Director, Investment & Finance t: +44 (0)141 548 3710 e: jr.davies@strath.ac.uk Barbara

  13. The Machinery of Knowledge: An Ontology-Registry for a Geospatial Knowledge

    E-Print Network [OSTI]

    Stock, Kristin

    1 The Machinery of Knowledge: An Ontology-Registry for a Geospatial Knowledge Infrastructure for Geospatial Science, University of Nottingham, UK 2 Allworlds Geothinking, UK 3 EDINA, UK 4 Cardiff University *Corresponding author: Centre for Geospatial Science, School of Geography, University of Nottingham, NG7 2RD, UK

  14. Instructions on How to Complete the Co-Curricular Global Registry

    E-Print Network [OSTI]

    Eustice, Ryan

    Instructions on How to Complete the Co-Curricular Global Registry ­ BLUE Lab - Biogas in Liberia@yahoo.com 7. Select NO. 8. Select YES, and enter BLUELab - Biogas #12;Are you travelling as part of an UM Danish Dutch English 9. Select YES 10. In the space provided, please enter: Engineering: BLUElab - Biogas

  15. Merrimack Valleyhousingreport An e-publication of UMass Lowell and the Middlesex North Registry of Deeds

    E-Print Network [OSTI]

    Massachusetts at Lowell, University of

    , recording statistics for the first six weeks of 2009 send a mixed message. The Middlesex North RegistryMassachusettsinfundingtogreenresi- dential buildings through energy efficiencies improvements and renewable energy installations. Included is over $100 million in increased funding to weatherize low-to-moderate income homes. Homeowners, tenants

  16. Public health assessment for V and M/Albaladejo Norte Ward (a/k/a V and M/Albaladejo Farms site), Vega Baja, Vega Baja County, Puerto Rico, Region 2: CERCLIS Number PRD987366101. Final report

    SciTech Connect (OSTI)

    NONE

    1998-12-30T23:59:59.000Z

    The Agency for Toxic Substances and Disease Registry (ATSDR) published a Site Review and Update for the V and M/Albaladejo Farms site on May 7, 1997. The site includes the V and M property and the Albaladejo farm. Total acreage is unknown. Several small plots within the site were formerly used for dumping plastic-coated electrical cables, electrical equipment, car batteries, and transformers. To total quantity of waste brought onto the site and the date when activities began are not known. Some wastes were burned, presumably to recover copper, aluminum, and lead. ATSDR prepared public health consultations in 1995 that concluded that site soils posed a potential health concern and concurred with EPA`s proposed cleanup levels. EPA also will investigate groundwater quality to determine whether remedial activities are needed to protect the aquifer that supplies off-site public wells that serve large numbers of residents in Vega Baja. ATSDR concluded that the site poses no apparent public health hazard. The proposed soil removal and proposed groundwater investigation and any required followup groundwater remediation should minimize the potential for future exposures and adverse human health effects.

  17. United States Transuranium and Uranium Registries. Annual report October 1, 1994 - September 30, 1995

    SciTech Connect (OSTI)

    Kathren, R.L.; Harwick, L.A.; Markel, M.J.

    1996-07-01T23:59:59.000Z

    The United States Transuranium and Uranium Registries (USTUR) comprise a human tissue research program studying the deposition, biokinetics and dosimetry of the actinide elements in humans with the primary goals of providing data fundamental to the verification, refinement, or future development of radiation protection standards for these and other radionuclides, and of determining possible bioeffects on both a macro and subcellular level attributable to exposure to the actinides. This report covers USTUR activities during the year from October 1994 through September 1995.

  18. United States transuranium and uranium registries. Annual report, October 1, 1995--September 30, 1996

    SciTech Connect (OSTI)

    Kathren, R.L.; Ehrhart, S.M. [eds.

    1997-04-01T23:59:59.000Z

    This Annual Report covers the period October 1, 1995 through September 30, 1996, and includes both scientific and administrative activities. As of September 30, 1996, the Registries had a total of 886 registrants of whom 350 were deceased and 292 classified as active. An anticipated funding cut of approximately 35% for the period beginning October 1, 1996, necessitated some staff cuts, but it is anticipated that the Registries core research will be maintained albeit at a somewhat slower pace. The Registries received approximately 60 public information requests or inquiries ranging over a wide range of topics, about a third of which came from the media or official agencies, including Congress. Specific noteworthy inquiries were received from the President`s Advisory Committee on the Gulf War Veterans with regard to uranium biokinetics and toxicity, and from the County of Los Angeles and the State of California with regard to the management and dosimetry of two separate instances of acute accidental intakes of {sup 241}Am.

  19. United States transuranium and uranium registries - 25 years of growth, research, and service. Annual report, April 1992--September 1993

    SciTech Connect (OSTI)

    Kathren, R.L.; Harwick, L.A.; Toohey, R.E.; Russell, J.J.; Filipy, R.E.; Dietert, S.E.; Hunacek, M.M.; Hall, C.A.

    1994-10-01T23:59:59.000Z

    The Registries originated in 1968 as the National Plutonium Registry with the name changed to the United States Transuranium Registry the following year to reflect a broader concern with the heavier actinides as well. Initially, the scientific effort of the USTR was directed towards study of the distribution and dose of plutonium and americium in occupationally exposed persons, and to assessment of the effects of exposure to the transuranium elements on health. This latter role was reassessed during the 1970`s when it was recognized that the biased cohort of the USTR was inappropriate for epidemiologic analysis. In 1978, the administratively separate but parallel United States Uranium Registry was created to carry out similar work among persons exposed to uranium and its decay products. A seven member scientific advisory committee provided guidance and scientific oversight. In 1992, the two Registries were administratively combined and transferred from the purview of a Department of Energy contractor to Washington State University under the provisions of a grant. Scientific results for the first twenty-five years of the Registries are summarized, including the 1985 publication of the analysis of the first whole body donor. Current scientific work in progress is summarized along with administrative activities for the period.

  20. United States Transuranium and Uranium Registries. Annuary report, February 1, 2004 - June 30, 2005

    SciTech Connect (OSTI)

    Ehrhart, Susan M.

    2006-05-31T23:59:59.000Z

    Three events of significance to the U. S. Transuranium and Uranium Registries (USTUR) occurred during this reporting period: 1. The search for a new Associate Director was successful in that Dr. Anthony C. (Tony) James was appointed to the position, 2. A five-year grant for the operation of the USTUR was approved by the U. S. Department of Energy; the previous grant cycles were for three years, 3. I retired from the USTUR Directorship on July 1, 2005 and Tony James became the new Director.

  1. British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry

    SciTech Connect (OSTI)

    Uberoi, Raman, E-mail: raman.Uberoi@orh.nhs.uk; Tapping, Charles Ross [Oxford University Hospitals, John Radcliffe Hospital, Department of Radiology (United Kingdom)] [Oxford University Hospitals, John Radcliffe Hospital, Department of Radiology (United Kingdom); Chalmers, Nicholas [Manchester Royal Infirmary, Department of Radiology (United Kingdom)] [Manchester Royal Infirmary, Department of Radiology (United Kingdom); Allgar, Victoria [University of York, Hull and York Medical School (United Kingdom)] [University of York, Hull and York Medical School (United Kingdom)

    2013-12-15T23:59:59.000Z

    Purpose: The British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry was produced to provide an audit of current United Kingdom (UK) practice regarding placement and retrieval of IVC filters to address concerns regarding their safety. Methods: The IVC filter registry is a web-based registry, launched by the BSIR on behalf of its membership in October 2007. This report is based on prospectively collected data from October 2007 to March 2011. This report contains analysis of data on 1,434 IVC filter placements and 400 attempted retrievals performed at 68 UK centers. Data collected included patient demographics, insertion and retrieval data, and patient follow-up. Results: IVC filter use in the majority of patients in the UK follows accepted CIRSE guidelines. Filter placement is usually a low-risk procedure, with a low major complication rate (<0.5 %). Cook Gunther Tulip (560 filters: 39 %) and Celect (359 filters: 25 %) filters constituted the majority of IVC filters inserted, with Bard G2, Recovery filters, Cordis Trapease, and OptEase constituting most of the remainder (445 filters: 31 %). More than 96 % of IVC filters deployed as intended. Operator inexperience (<25 procedure) was significantly associated with complications (p < 0.001). Of the IVC filters initially intended for temporary placement, retrieval was attempted in 78 %. Of these retrieval was technically successful in 83 %. Successful retrieval was significantly reduced for implants left in situ for >9 weeks versus those with a shorter dwell time. New lower limb deep vein thrombosis (DVT) and/or IVC thrombosis was reported in 88 patients following filter placement, there was no significant difference of incidence between filter types. Conclusions: This registry report provides interventional radiologists and clinicians with an improved understanding of the technical aspects of IVC filter placement to help improve practice, and the potential consequences of IVC filter placement so that we are better able to advise patients. There is a significant learning curve associated with IVC filter insertion, and when a filter is placed with the intention of removal, procedures should be in place to avoid the patient being lost to follow-up.

  2. Federal Registry Comments May 4-9, 2007. | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport inEnergy June 6-7, 2013 Meeting Federal Register NoticeFederal Registry

  3. Assigning unique identification numbers to new user accounts and groups in a computing environment with multiple registries

    DOE Patents [OSTI]

    DeRobertis, Christopher V. (Hopewell Junction, NY); Lu, Yantian T. (Round Rock, TX)

    2010-02-23T23:59:59.000Z

    A method, system, and program storage device for creating a new user account or user group with a unique identification number in a computing environment having multiple user registries is provided. In response to receiving a command to create a new user account or user group, an operating system of a clustered computing environment automatically checks multiple registries configured for the operating system to determine whether a candidate identification number for the new user account or user group has been assigned already to one or more existing user accounts or groups, respectively. The operating system automatically assigns the candidate identification number to the new user account or user group created in a target user registry if the checking indicates that the candidate identification number has not been assigned already to any of the existing user accounts or user groups, respectively.

  4. Evaluation of metrics and baselines for tracking greenhouse gas emissions trends: Recommendations for the California climate action registry

    SciTech Connect (OSTI)

    Price, Lynn; Murtishaw, Scott; Worrell, Ernst

    2003-06-01T23:59:59.000Z

    Executive Summary: The California Climate Action Registry, which was initially established in 2000 and began operation in Fall 2002, is a voluntary registry for recording annual greenhouse gas (GHG) emissions. The purpose of the Registry is to assist California businesses and organizations in their efforts to inventory and document emissions in order to establish a baseline and to document early actions to increase energy efficiency and decrease GHG emissions. The State of California has committed to use its ''best efforts'' to ensure that entities that establish GHG emissions baselines and register their emissions will receive ''appropriate consideration under any future international, federal, or state regulatory scheme relating to greenhouse gas emissions.'' Reporting of GHG emissions involves documentation of both ''direct'' emissions from sources that are under the entity's control and indirect emissions controlled by others. Electricity generated by an off-site power source is consider ed to be an indirect GHG emission and is required to be included in the entity's report. Registry participants include businesses, non-profit organizations, municipalities, state agencies, and other entities. Participants are required to register the GHG emissions of all operations in California, and are encouraged to report nationwide. For the first three years of participation, the Registry only requires the reporting of carbon dioxide (CO2) emissions, although participants are encouraged to report the remaining five Kyoto Protocol GHGs (CH4, N2O, HFCs, PFCs, and SF6). After three years, reporting of all six Kyoto GHG emissions is required. The enabling legislation for the Registry (SB 527) requires total GHG emissions to be registered and requires reporting of ''industry-specific metrics'' once such metrics have been adopted by the Registry. The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab) was asked to provide technical assistance to the California Energy Commission (Energy Commission) related to the Registry in three areas: (1) assessing the availability and usefulness of industry-specific metrics, (2) evaluating various methods for establishing baselines for calculating GHG emissions reductions related to specific actions taken by Registry participants, and (3) establishing methods for calculating electricity CO2 emission factors. The third area of research was completed in 2002 and is documented in Estimating Carbon Dioxide Emissions Factors for the California Electric Power Sector (Marnay et al., 2002). This report documents our findings related to the first areas of research. For the first area of research, the overall objective was to evaluate the metrics, such as emissions per economic unit or emissions per unit of production that can be used to report GHG emissions trends for potential Registry participants. This research began with an effort to identify methodologies, benchmarking programs, inventories, protocols, and registries that u se industry-specific metrics to track trends in energy use or GHG emissions in order to determine what types of metrics have already been developed. The next step in developing industry-specific metrics was to assess the availability of data needed to determine metric development priorities. Berkeley Lab also determined the relative importance of different potential Registry participant categories in order to asses s the availability of sectoral or industry-specific metrics and then identified industry-specific metrics in use around the world. While a plethora of metrics was identified, no one metric that adequately tracks trends in GHG emissions while maintaining confidentiality of data was identified. As a result of this review, Berkeley Lab recommends the development of a GHG intensity index as a new metric for reporting and tracking GHG emissions trends.Such an index could provide an industry-specific metric for reporting and tracking GHG emissions trends to accurately reflect year to year changes while protecting proprietary data. This GHG intensity index changes

  5. What is the GTR? The NIH Genetic Testing Registry (GTR) is a centralized repository of genetic test information voluntarily supplied by test providers.

    E-Print Network [OSTI]

    Levin, Judith G.

    What is the GTR? The NIH Genetic Testing Registry (GTR) is a centralized repository of genetic test information voluntarily supplied by test providers. The scope of the Registry includes the purpose, methodology, validity, and evidence of utility of each test, as well as laboratory contacts and credentials

  6. www.thelancet.com Vol 377 March 26, 2011 1057 The case for a global rare-diseases registry

    E-Print Network [OSTI]

    Manstein, Dietmar J.

    increased substantially in India over the past decade.4 What then are the key goals that policy should Ministry of Health and Family Welfare, Government of India. National health policy. 2002. http on public health research. Although a full analysisof all present funding for health research in India

  7. United States Transuranium and Uranium Registries. Annual Report, October 1, 1993--September 30, 1994

    SciTech Connect (OSTI)

    Kathren, R.L.; Harwick, L.A. [comps.] [eds.

    1995-08-01T23:59:59.000Z

    This report summarizes the salient activities and progress of the United States Transuranium. and Uranium Registries for the period October 1, 1993 through September 30, 1994, along with details of specific programs areas including the National Human Radiobiology Tissue Repository (NHRTR) and tissue radiochemistry analysis project. Responsibility for tissue radioanalysis was transferred from Los Alamos National Laboratory to Washington State University in February 1994. The University of Washington was selected as the Quality Assurance/Quality Control laboratory and a three way intercomparison with them and LANL has been initiated. The results of the initial alpha spectrometry intercomparison showed excellent agreement among the laboratories and are documented in full in the Appendices to the report. The NHRTR serves as the initial point of receipt for samples received from participants in the USTUR program. Samples are weighed, divided, and reweighed, and a portion retained by the NHRTR as backup or for use in other studies. Tissue specimens retained in the NHRTR are maintained frozen at -70 C and include not only those from USTUR registrants but also those from the radium dial painter and thorium worker studies formerly conducted by Argonne National Laboratory. In addition, there are fixed tissues and a large collection of histopathology slides from all the studies, plus about 20,000 individual solutions derived from donated tissues. These tissues and tissue related materials are made available to other investigators for legitimate research purposes. Ratios of the concentration of actinides in various tissues have been used to evaluate the biokinetics, and retention half times of plutonium and americium. Retention half times for plutonium in various soft tissues range from 10-20 y except for the testes for which a retention half time of 58 y was observed. For americium, the retention half time in various soft tissues studied was 2.2-3.5 y.

  8. Information Regarding MENINGOCOCCAL DISEASE

    E-Print Network [OSTI]

    . Meningococcal disease is a serious disease, caused by bacteria. Meningococcal disease is a contagious

  9. Evaluation of Current Consensus Statement Recommendations for Accelerated Partial Breast Irradiation: A Pooled Analysis of William Beaumont Hospital and American Society of Breast Surgeon MammoSite Registry Trial Data

    SciTech Connect (OSTI)

    Wilkinson, J. Ben [Department of Radiation Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States)] [Department of Radiation Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States); Beitsch, Peter D. [Dallas Surgical Group, Dallas, Texas (United States)] [Dallas Surgical Group, Dallas, Texas (United States); Shah, Chirag [Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri (United States)] [Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri (United States); Arthur, Doug [Department of Radiation Oncology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia (United States)] [Department of Radiation Oncology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia (United States); Haffty, Bruce G. [Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Camden, New Jersey (United States)] [Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Camden, New Jersey (United States); Wazer, David E. [Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts and Rhode Island Hospital/Brown University, Providence, Rhode Island (United States)] [Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts and Rhode Island Hospital/Brown University, Providence, Rhode Island (United States); Keisch, Martin [Department of Radiation Oncology, Cancer Healthcare Associates, Miami, Florida (United States)] [Department of Radiation Oncology, Cancer Healthcare Associates, Miami, Florida (United States); Shaitelman, Simona F. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lyden, Maureen [Biostat International, Inc, Tampa, Florida (United States)] [Biostat International, Inc, Tampa, Florida (United States); Chen, Peter Y. [Department of Radiation Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States)] [Department of Radiation Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States); Vicini, Frank A., E-mail: fvicini@pol.net [Department of Radiation Oncology, Michigan Healthcare Professionals/21st Century Oncology, Farmington Hills, Michigan (United States)

    2013-04-01T23:59:59.000Z

    Purpose: To determine whether the American Society for Radiation Oncology (ASTRO) Consensus Statement (CS) recommendations for accelerated partial breast irradiation (APBI) are associated with significantly different outcomes in a pooled analysis from William Beaumont Hospital (WBH) and the American Society of Breast Surgeons (ASBrS) MammoSite® Registry Trial. Methods and Materials: APBI was used to treat 2127 cases of early-stage breast cancer (WBH, n=678; ASBrS, n=1449). Three forms of APBI were used at WBH (interstitial, n=221; balloon-based, n=255; or 3-dimensional conformal radiation therapy, n=206), whereas all Registry Trial patients received balloon-based brachytherapy. Patients were divided according to the ASTRO CS into suitable (n=661, 36.5%), cautionary (n=850, 46.9%), and unsuitable (n=302, 16.7%) categories. Tumor characteristics and clinical outcomes were analyzed according to CS group. Results: The median age was 65 years (range, 32-94 years), and the median tumor size was 10.0 mm (range, 0-45 mm). The median follow-up time was 60.6 months. The WBH cohort had more node-positive disease (6.9% vs 2.6%, P<.01) and cautionary patients (49.5% vs 41.8%, P=.06). The 5-year actuarial ipsilateral breast tumor recurrence (IBTR), regional nodal failure (RNF), and distant metastasis (DM) for the whole cohort were 2.8%, 0.6%, 1.6%. The rate of IBTR was not statistically higher between suitable (2.5%), cautionary (3.3%), or unsuitable (4.6%) patients (P=.20). The nonsignificant increase in IBTR for the cautionary and unsuitable categories was due to increased elsewhere failures and new primaries (P=.04), not tumor bed recurrence (P=.93). Conclusions: Excellent outcomes after breast-conserving surgery and APBI were seen in our pooled analysis. The current ASTRO CS guidelines did not adequately differentiate patients at an increased risk of IBTR or tumor bed failure in this large patient cohort.

  10. Disease Prediction Models and Operational Readiness

    SciTech Connect (OSTI)

    Corley, Courtney D.; Pullum, Laura L.; Hartley, David M.; Benedum, Corey M.; Noonan, Christine F.; Rabinowitz, Peter M.; Lancaster, Mary J.

    2014-03-19T23:59:59.000Z

    INTRODUCTION: The objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information for decision makers to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews. First, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. Second, we considered models involving pathogens of concern as determined by the US National Select Agent Registry (as of June 2011). Methods: We searched dozens of commercial and government databases and harvested Google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, The publication date of search results returned are bound by the dates of coverage of each database and the date in which the search was performed, however all searching was completed by December 31, 2010. This returned 13,767 webpages and 12,152 citations. After de-duplication and removal of extraneous material, a core collection of 6,503 items was established and these publications along with their abstracts are presented in a semantic wiki at http://BioCat.pnnl.gov. Next, PNNL’s IN-SPIRE visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model resulting in the selection of 54 documents that matched the criteria resulting Ten of these documents, However, dealt purely with disease spread models, inactivation of bacteria, or the modeling of human immune system responses to pathogens rather than predicting disease events. As a result, we systematically reviewed 44 papers and the results are presented in this analysis.

  11. Bullous Lung Disease

    E-Print Network [OSTI]

    Goldberg, Corey; Carey, Kathleen E

    2013-01-01T23:59:59.000Z

    thorascopic surgery. Bullous Lung Disease REFERENCES 1.S, Kaiser LR. Giant bullous lung disease: evaluation,for bullous disease of the lung. Eur J Cardiothorac Surg.

  12. Inside Alzheimer's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    reveal conditions that lead to the disease's signature tangles and plaques in the brain March 12, 2015 Inside Alzheimer's Disease Neuron membrane disruption may underlie...

  13. Molecular Bioinformatics for Diseases

    E-Print Network [OSTI]

    Radivojac, Predrag

    . Curr Opin Pediatr, 13: 22 (2001). Leads to sickle cell anemia Manifestation of disease vastly different

  14. Kidney Disease of Diabetes

    E-Print Network [OSTI]

    Baker, Chris I.

    Kidney Disease of Diabetes National Kidney and Urologic Diseases Information Clearinghouse is the final stage of chronic kidney disease (CKD). Diabetes is the most common cause of kidney failure, accounting for nearly 44 percent of new cases.1 Even when diabetes is controlled, the disease can lead to CKD

  15. Childhood lead poisoning near abandoned lead mining and smelting areas: A case study of two affected households

    SciTech Connect (OSTI)

    Moehr, A.D. (Jasper County Health Dept., Webb City, MO (United States)); Roberts, D.W.; Phillips, P.E.; Evans, R.G.

    1993-10-01T23:59:59.000Z

    In October, 1990 the Missouri Dept. of Health entered a contract with the Agency for Toxic Substances and Disease Registry (ATSDR) to conduct an exposure study at the Jasper County, Missouri Superfund Site. The primary concern was exposure to elevated levels of lead and cadmium resulting from previous mining of lead and zinc in the area. Several individuals were found to have elevated lead levels and this article is a case study of two households where children with elevated levels resided. Due to the lowering of the Centers for Disease Control and Prevention (CDC) standard for a level of concern in childhood lead poisoning from 25 [mu]g/dl to 10 [mu]g/dl, many environmental heath personnel may be requested to evaluate exposure routes and give advice regarding risk reduction to families who reside in areas not previously thought to be problematic. Accomplishing this risk reduction may require passage of local ordinances requiring lead abatement, additional training of field personnel, and cooperative work with other public and governmental entities.

  16. Interim Chronic Beryllium Disease

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-12-08T23:59:59.000Z

    Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

  17. Cardiovascular Disease (CVD) Coronary heart disease

    E-Print Network [OSTI]

    Dever, Jennifer A.

    have a greater prevalence in women · Osteoporosis · Autoimmune disease A. Osteoporosis · Osteoporosis ­ disorder of low bone mass, microarchitectural denegra7on% of all women >65 years old have osteoporosis (15% of all Caucasian women

  18. Health assessment for Oronogo-Duenweg Mining Belt, Jasper County, Missouri, Region 7. CERCLIS No. MDD980686281. Preliminary report

    SciTech Connect (OSTI)

    Not Available

    1990-06-18T23:59:59.000Z

    The Oronogo-Duenweg Mining Belt site, Jasper County, Missouri, has been proposed by the U.S. Environmental Protection Agency (EPA) for inclusion on the National Priorities List (NPL). Referred to as the Missouri portion of the Tri-State (Missouri, Kansas, and Oklahoma) Mining District, the site comprises approximately 20 square miles and was the location of the most concentrated mining effort in the Tri-State District. As a result of commercial zinc and lead mining operations that occurred from about 1850 until the late 1960s, shallow groundwater, surface water, sediment, and surface soil are contaminated with heavy metals (zinc, lead, cadmium, and nickel). Municipalities in the area use both surface water and a deep aquifer for water supplies; individual households outside these centers rely on a shallow aquifer for water. Based upon information reviewed, the Agency for Toxic Substances and Disease Registry (ATSDR) has concluded that this site is of public health concern because of the risk to human health resulting from probable exposure to hazardous substances at concentrations that may result in adverse human health effects.

  19. Use of information resources by the state of Tennessee in risk assessment applications

    SciTech Connect (OSTI)

    Bashor, B.S. [Tennessee Department of Health and Environment, Nashville (United States)

    1990-12-31T23:59:59.000Z

    The major resources used by the Bureau of Environment, and Environmental Epidemiology (EEP) for risk assessment are: the Integrated Risk Information System (IRIS), Health and Environmental Effects Summary Table (HEAST), Agency for Toxic Substances and disease Registry (ATSDR) Toxicological Profiles, databases at the National Library of Medicine (NLM), World Health Organization (WHO) ENvironmental Criteria, and documents that the Environmental Protection Agency (EPA) has published on Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) risk assessment activities. The Risk Assessment Review has been helpful in providing information about availability of new documents or information. No systematic method has been made available to us to locate information resources. IRIS User`s Support has been helpful in making appropriate and timely referrals. Most other EPA resources were located by serendipity and persistence. The CERCLA methodology for risk assessments is being used in environmental programs, and at present, one person is responsible for all risk assessment activities in the department, but plans are underway to train one or two people from each program area. 2 figs.

  20. Adventures in Infectious Diseases

    ScienceCinema (OSTI)

    Fisher-Hoch, Susan [University of Texas School of Public Health

    2014-06-25T23:59:59.000Z

    Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

  1. Chronic Conditions and Disease Prevention

    E-Print Network [OSTI]

    , diabetes, heart disease and osteoarthritis. One-on-One Nutrition Counseling Help with weight management and supportive program for those who have chronic diseases such as diabetes, heart disease, stroke, arthritis

  2. Large scale disease prediction

    E-Print Network [OSTI]

    Schmid, Patrick R. (Patrick Raphael)

    2008-01-01T23:59:59.000Z

    The objective of this thesis is to present the foundation of an automated large-scale disease prediction system. Unlike previous work that has typically focused on a small self-contained dataset, we explore the possibility ...

  3. Health & Medicine Heart Disease

    E-Print Network [OSTI]

    Rogers, John A.

    See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

  4. Periodontal Disease and Heart Health

    E-Print Network [OSTI]

    Goldman, Steven A.

    Periodontal Disease and Heart Health Deaf HealthTalks Presenter: Christopher Lehfeldt, DDS Elmwood #12;X-ray showing bone loss rickwilsondmd.typepad.com Thursday, March 15, 12 #12;5. What is heart disease? · The medical name for heart disease is cardiovascular disease (CVD) · An American dies from CVD

  5. Reproductive Diseases in Cattle

    E-Print Network [OSTI]

    Sprott, L. R.; Field, Bob

    1998-12-03T23:59:59.000Z

    susceptible. Droplets of urine from infected cows can infect normal cows after contact with the eye or mucous membranes of the nose or mouth. The disease infects more cattle each day, preventing cows from settling and lengthening their calving intervals... abortus) fetal membranes from aborting heifers at 4-12 not vaccinate bulls. cow; fetus; months. placenta Leptospirosis Bacterial (At least Urine of infected Any stage, Sample 10 Every 6 months Laboratory should deter- 5 serotypes) animals...

  6. Inherited risk for common disease

    E-Print Network [OSTI]

    Banava, Helen

    2007-01-01T23:59:59.000Z

    Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

  7. Development of Graves' disease following radiation therapy in Hodgkin's disease

    SciTech Connect (OSTI)

    Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

    1988-01-01T23:59:59.000Z

    Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

  8. A Manual of Poultry Diseases.

    E-Print Network [OSTI]

    Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

    1965-01-01T23:59:59.000Z

    " of ocular leucosis is specific. Hatchery and Breeder Flock Health Management Sanitation is a much used, but poorly defined word. The usual implication is that sanitation is a universally understood practice that may be applied to prevent all diseases... must be based on the nature of specific diseases. The ;kmbiguity surrounding the term "sanitation" can be avoided by using a term "management and sanitation for disease prevention." This phrase then would be defined as all practices, specific...

  9. Using Wikipedia to forecast diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    said. "In the same way we check the weather each morning, individuals and public health officials can monitor disease incidence and plan for the future based on today's...

  10. MFR PAPER 1300 Shellfish Diseases

    E-Print Network [OSTI]

    promise for the efficient recycling of organic waste materials, such as agricultural wastes, and metazoan parasitic and infectious agents. In addition, predators, toxic agents, and fouling organisms studied. DISEASES OF SHELLFISH A list of organisms that cause com- mon diseases in oysters is shown

  11. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09T23:59:59.000Z

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  12. Lessons from a rare disease

    E-Print Network [OSTI]

    Dutchen, Stephanie Lynn

    2009-01-01T23:59:59.000Z

    Progeria is a genetic aging disease of childhood affecting an estimated one in four to eight million births. Children with progeria experience a range of developmental disorders and aging-like symptoms, including wrinkled ...

  13. A Manual of Poultry Diseases.

    E-Print Network [OSTI]

    Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

    1971-01-01T23:59:59.000Z

    surrounding the term "sanitation" can be avoided by using the expression "management and sanitation for disease preven- , tion." This phrase then would be defined as all practices, specific and nonspecific, that the poultry- man applies to ptevent.... Change litter and thoroughly clean and disinfect the house and equipment between each group of birds. While litter selection and management is a large subject, applying this recommendation as a general practice will prevent many disease and parasite...

  14. A Century of Progress: Milestones in Sickle Cell Disease

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Disease? Sickle cell disease, also known as sickle cell anemia, is inherited. People who have the disease

  15. Imaging Lung Disease in Systemic Sclerosis

    E-Print Network [OSTI]

    Strollo, Diane; Goldin, Jonathan

    2010-01-01T23:59:59.000Z

    W, et al. : Interstitial lung disease in progressiveGL, Myers JL: Diffuse lung disease: diagnostic accuracy ofsurgical biopsy of the lung. Radiology 1997, 205:229–234.

  16. Heart Disease and Early Heart Attack Care

    E-Print Network [OSTI]

    Ohta, Shigemi

    Heart Disease and Early Heart Attack Care Pamela Kostic, RN, CCCC, Chest Pain Coordinator, Stony Risk Factors · EHAC & Prevention #12;Heart disease includes a number of problems affecting the heart and the blood vessels in the heart. #12;Types of heart disease include: · Coronary artery disease (CAD) · Angina

  17. Radiologic atlas of rheumatic diseases

    SciTech Connect (OSTI)

    Dihlmann, W.

    1986-01-01T23:59:59.000Z

    This book is an ''atlas of rheumatic joint disease'' selected from 20 years of personal experience by the author. The author sets a goal of demonstrating the value of soft-tissue imaging in the diagnosis of early joint disease. This goal is achieved with high quality reproductions, many of which are presented in duplicate to illustrate bone and soft-tissue changes. The contents include an introductory overview of the ''Mosaic of Arthritis'' followed by sections on adult rheumatoid arthritis, seronegative spondyloarthropathies, classic collagen disease, enthesiopathies, and lastly a section on gout and psuedogout. The subject index is specific and indexes figures with boldface type. Each section is introduced by a brief outline or overview of the radiographic spectrum of the joint disorder to be illustrated.

  18. Easy Gardening.....Disease Control 

    E-Print Network [OSTI]

    Johnson, Jerral; Johnson, Jerral

    2009-05-29T23:59:59.000Z

    on plant roots and cause stunted plants. The most damaging nematode in the home garden is root knot. It causes galls or knots on susceptible plants such as toma- A good home gardener recognizes the symptoms of plant diseases quickly and takes steps...

  19. Environmental Contributions to Allergic Disease

    E-Print Network [OSTI]

    Levetin, Estelle

    with increased exposure to air pollution and indoor contaminants such as house dust mites, cockroaches linked to the severity of allergic disease. The contribution of house dust mites, cockroaches, animal some of the strongest evidence sug- gests a compelling link between exposure to passive smoking

  20. Greenhouse Gas Inventory and Registry (Iowa)

    Broader source: Energy.gov [DOE]

    The Iowa Department of Natural Resources is required to establish a method for collecting emissions estimates from producers of greenhouse gases. Reporting is mandatory for some entities, and the...

  1. Development of a Texas Building Registry

    E-Print Network [OSTI]

    Gilman, D. R.; Haberl, J.; Kayati, M.; O'Neal, S.

    BUILDINGS This will be a collection of building descriptions. In the 2009 version, this was specifically the IC3/TCV data structure. ESL-HH-10-08-15 Houses PK id int identity Orientation int PilotLights int Infiltration float FK2 MechId int FK...1 ElecId int FK3 StructId int IsDirty bit County varchar(100) Projects PK Id numeric(18,0) identity Name varchar(50) Address varchar(50) FK4 HouseId int FK3 BuilderId int FK1 BuildersReportId int City varchar(50) Zip varchar(10...

  2. Beryllium Associated Worker Registry Summary 2012

    Office of Environmental Management (EM)

    submission at all for 5 sites. Exposure sampling data were submitted by 25 industrial hygiene programs for sites and subcontractors that have continuing beryllium operations or...

  3. 2013 Beryllium-Associated Worker Registry Summary

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015ofDepartment ofCBFO-13-3322(EE) |2Department of Energyof Environmental Table

  4. California Climate Action Registry | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty EditCalifornia:Power LP Biomass Facilityin Charts Jump28 2013

  5. ORISE: REAC/TS Radiation Accident Registries

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated CodesTransparencyDOENurse Triage LinesCytogeneticHow ORISE is

  6. Climate Registry Information System | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof EnergyInnovationin UrbanCity ofCityClean EconomyLLCInformationFunds

  7. Why Do We Get Alzheimer's Disease?

    SciTech Connect (OSTI)

    Wyss-Coray, Tony (Stanford University) [Stanford University

    2006-01-02T23:59:59.000Z

    Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

  8. New Clues in Predicting Alzheimer's Disease

    ScienceCinema (OSTI)

    Jagust, William

    2013-05-29T23:59:59.000Z

    Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

  9. MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW

    E-Print Network [OSTI]

    Missouri-Rolla, University of

    , coughing and having close social contact (living in the same household) are examples of how this disease

  10. Are You at Risk for Heart Disease?

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Are You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Are You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Sakit sa Puso? Malusog na Puso, Malusog na Pamilya #12;Did you know that heart disease is a serious problem

  11. Coronary Heart Disease, Hypertension, Stroke, and

    E-Print Network [OSTI]

    Meagher, Mary

    Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart · Disease process: coronary and arms Myocardial infarction - heart attack, ischemia - local blood supply decreased resulting in cell

  12. Controlling Diseases on Ornamental Plants.

    E-Print Network [OSTI]

    Horne, C. Wendell; Johnson, Jerral D.; Walla, Walter J.

    1979-01-01T23:59:59.000Z

    powder is used as a spray to control powdery mildew and foliage diseases. It is available as Daconil 2787?, Bravo? and Ferti-Iome Broad Spectrum Liquid Fungicide?. Formaldehyde: This is a 37 percent solution in water and methanol which is used... and move it over the loosened soil. Drain tile or iron pipe buried in the soil helps to distribute the ste~m. Heat the soil until a medium-sized potato buried several inches deep is cooked thoroughly. Use formaldehyde as manufacturer directs. Water...

  13. Diseases of Peaches and Plums.

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01T23:59:59.000Z

    Uetial ' . " ~. -~c _ '1-" ,," 'J .~. ," .. " Each year diseases destroy a large portion of the potential fruit crop in Texas. This loss begins in the orchard and continues until the fruit is con sumed. Complete lack of production on improperly sprayed trees... enough pressure to break through the bark and flow down the outside of a tree limb. Cankers will have a sour smell similar to that fol lowing a freeze. Although leaf spotting has been reported, it does not always occur. In Texas, leaf spotting has...

  14. Characterization of Lung's Emphysema Distribution: Numerical Assessment of Disease Development

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Characterization of Lung's Emphysema Distribution: Numerical Assessment of Disease Development M, Egypt. Abstract--Chronic Obstructive Pulmonary Disease (COPD) refers to a group of lung diseases bronchitis. Pulmonary emphysema is defined as a lung disease characterized by "abnormal enlargement

  15. Survival after bilateral lung transplantation versus single lung transplantation for patients with chronic obstructive pulmonary disease.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Survival after bilateral lung transplantation versus single lung transplantation for patients, Pennsylvania, USA. 8 International Heart and Lung Transplant Registry, Addison, Texas. Word count: 3204 Background: Both single and bilateral lung transplantation (LT) are recognized options for patients with end

  16. Imaging Lung Disease in Systemic Sclerosis

    E-Print Network [OSTI]

    Strollo, Diane; Goldin, Jonathan

    2010-01-01T23:59:59.000Z

    undergoing surgical biopsy of the lung. Radiology 1997, 205:disease. In Pathology of the Lung. Edited by Thurlbeck WM,organs, most frequently the lungs and gastrointes- tinal

  17. Enzyme replacement therapy for Pompe disease

    E-Print Network [OSTI]

    Burris, Ryan Jonathan William

    2010-01-01T23:59:59.000Z

    CALIFORNIA, SAN DIEGO Enzyme Replacement Therapy for Pompe3 1.3 Enzyme Replacement Therapy for Pompe Disease…………………… 5Receptor ERT – Enzyme Replacement Therapy LSD – Lysosomal

  18. Mathematical Model Applications to Disease and Homeland ...

    E-Print Network [OSTI]

    Mathematical Model Applications to Disease and Homeland Security The events of ... but have no data or reliable information that would help in the planning or ...

  19. Fracture, aging and disease in bone

    E-Print Network [OSTI]

    Ager, J.W.; Balooch, G.; Ritchie, R.O.

    2006-01-01T23:59:59.000Z

    on glucocorticoid-induced osteoporosis. Rheumatic DiseaseGlucocorticoid-induced osteoporosis. Endocrinol Metab. Clin.of cortico-steroid osteoporosis. A meta-analysis. Osteoporos

  20. Undifferentiated Connective Tissue Disease-Associated Interstitial Lung Disease: Changes in Lung Function

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Lung (2010) 188:143–149 DOI 10.1007/s00408-009-Tissue Disease-Associated Interstitial Lung Disease:Changes in Lung Function Brent W. Kinder • Cyrus Shariat •

  1. COMMON DISEASES OF FUR BEARING ANIMALS II. DISEASES OF CHINCHILLAS, NUTRIA, AND RABBITS*

    E-Print Network [OSTI]

    COMMON DISEASES OF FUR BEARING ANIMALS II. DISEASES OF CHINCHILLAS, NUTRIA, AND RABBITS* T. J. Pridhamt, Joan Buddt, and L. H. A. Karstadt DISEASES OF THE CHINCHILLA BACTERIAL INFECTIONS and errors in management are the most common causes of death in the chinchillas submitted to this laboratory. LISTERIOSIS

  2. Coronary Heart Disease, Hypertension, Stroke, and

    E-Print Network [OSTI]

    Meagher, Mary

    Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview to illnesses caused by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart that radiates across the chest and arms Ø Myocardial infarction - heart attack, ischemia - local blood supply

  3. X-ray atlas of rheumatic diseases

    SciTech Connect (OSTI)

    Dihlmann, W.

    1986-01-01T23:59:59.000Z

    This atlas comprises instructive X-rays of the various inflammatory rheumatic joint diseases in all stages at the extremities and the spinal column. In addition, the complex pattern of the wide range of arthroses, also known as degenerative rheumatic disease is included. Besides the instructive pointers to X-ray diagnosis, the book is also a guide to differential diagnosis. Hence, this book is actually an X-ray atlas of joint diseases in general. Selected Contents: Introduction: What Does ''Rheumatism'' Actually Mean./Radiographic Methodology in Rheumatic Diseases of the Locomotor System/The Mosaic of Arthritis/Adult Rheumatoid Arthritis/Seronegative Spondylarthritis/Classic Collagen Diseases/Enthesiopathies/Gout-Pseudogout

  4. Study of collagen structure in canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Hadian, Mojtaba

    2009-01-01T23:59:59.000Z

    Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs, and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans ...

  5. Behavioral impulsivity and hallucinations : insights from Parkinson's disease

    E-Print Network [OSTI]

    Ashourian, Paymon

    2011-01-01T23:59:59.000Z

    Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

  6. Chemicals for Plant Disease Control at Home

    E-Print Network [OSTI]

    Ong, Kevin

    2007-10-30T23:59:59.000Z

    common chemical names and the corresponding chemical name for each active ingredient. Kevin Ong* ?Assistant Professor and Extension Plant Pathologist, The Texas A&M University System Table 1. Plant disease control chemicals. Common name Chemical name 1...

  7. HLB in Argentina: a New Disease Outbreak

    E-Print Network [OSTI]

    2014-01-01T23:59:59.000Z

    Vol. 1 (2014) HLB in Argentina: a New Disease Outbreak Outi,E. 6 SENASA, Bs. As. Argentina MAGyP Bs. As INTA Montecarlo,Paraná, 300 km away from Argentina’s Northeastern border. In

  8. Restoration of Endangered White Abalone, Haliotis sorenseni: Resource Assessment, Genetics, Disease and Culture of Captive Abalone

    E-Print Network [OSTI]

    Burton, Ronald S.; McCormick, Thomas B.; Moore, James D.; Friedman, Carolyn S.

    2008-01-01T23:59:59.000Z

    Haliotis sorenseni: Resource Assessment, Genetics, Disease,Haliotis sorenseni: Resource Assessment, Genetics, Disease,Haliotis sorenseni: Resource Assessment, Genetics, Disease,

  9. adult celiac disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: with a dietitian or physician who specializes in celiac disease. People with celiac disease should always read food for Celiac Awareness; Cynthia Kupper,...

  10. arthritis disease activity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systemic, inflammatory disease causing disability. Identifying factors that influence the impact of the disease is important for planning adequate (more) Kuhlow, Heide 2007-01-01...

  11. ASSISTANT/ASSOCIATE/FULL PROFESSOR Diabetes, Obesity, Metabolic Disease

    E-Print Network [OSTI]

    Cinabro, David

    ASSISTANT/ASSOCIATE/FULL PROFESSOR Diabetes, Obesity, Metabolic Disease Department strengths in diabetes, obesity and metabolic disease. Outstanding candidates with expertise

  12. Integrated Molecular Signature of Disease: Analysis of Influenza...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Disease: Analysis of Influenza Virus-Infected Macaques through Functional Genomics and Integrated Molecular Signature of Disease: Analysis of Influenza Virus-Infected...

  13. Structural genomics of infectious disease drug targets: the SSGCID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

  14. The Seattle Structure Genomics Center for Infectious Disease...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Seattle Structure Genomics Center for Infectious Disease (SSGCID). The Seattle Structure Genomics Center for Infectious Disease (SSGCID). Abstract: The NIAID-funded Seattle...

  15. alzheimers disease amyloid: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

  16. alzheimer disease current: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diagnosis of Alzheimers disease: CiteSeer Summary: update on combining genetic and brain-imaging measures Gary W. Small, MD Diagnosis of Alzheimers disease is often missed...

  17. alzheimer disease amyloid: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

  18. anthracnose disease control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease of papaya Babak Madani a,*, Mahmud Tengku Muda Mohamed a,**, Alan R. Biggs c , Jugah Kadir October 2013 Keywords: Papaya Anthracnose Calcium Disease incidence...

  19. anthracnose disease caused: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease of papaya Babak Madani a,*, Mahmud Tengku Muda Mohamed a,**, Alan R. Biggs c , Jugah Kadir October 2013 Keywords: Papaya Anthracnose Calcium Disease incidence...

  20. A Systems Biology Approach to Infectious Disease Research: Innovating...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm. A Systems Biology Approach to Infectious Disease Research: Innovating the...

  1. Chronic beryllium disease: Diagnosis and management

    SciTech Connect (OSTI)

    Rossman, M.D. [Hospital of the Univ. of Pennsylvania, Philadelphia, PA (United States)

    1996-10-01T23:59:59.000Z

    Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4{sup +} T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease. 21 refs.

  2. Transgenic Mouse Model of Chronic Beryllium Disease

    SciTech Connect (OSTI)

    Gordon, Terry

    2009-05-26T23:59:59.000Z

    Animal models provide powerful tools for dissecting dose-response relationships and pathogenic mechanisms and for testing new treatment paradigms. Mechanistic research on beryllium exposure-disease relationships is severely limited by a general inability to develop a sufficient chronic beryllium disease animal model. Discovery of the Human Leukocyte Antigen (HLA) - DPB1Glu69 genetic susceptibility component of chronic beryllium disease permitted the addition of this human beryllium antigen presentation molecule to an animal genome which may permit development of a better animal model for chronic beryllium disease. Using FVB/N inbred mice, Drs. Rubin and Zhu, successfully produced three strains of HLA-DPB1 Glu 69 transgenic mice. Each mouse strain contains a haplotype of the HLA-DPB1 Glu 69 gene that confers a different magnitude of odds ratio (OR) of risk for chronic beryllium disease: HLA-DPB1*0401 (OR = 0.2), HLA-DPB1*0201 (OR = 15), HLA-DPB1*1701 (OR = 240). In addition, Drs. Rubin and Zhu developed transgenic mice with the human CD4 gene to permit better transmission of signals between T cells and antigen presenting cells. This project has maintained the colonies of these transgenic mice and tested the functionality of the human transgenes.

  3. Thomas E. Hinds Although many diseases attack aspen, relatively few

    E-Print Network [OSTI]

    DISEASES Thomas E. Hinds Although many diseases attack aspen, relatively few kill or seriously of aspen, whereas there are subtle differ- ences in distribution between the important decay fungi. Foliage Diseases Fungus Diseases Many fungi are capable of attacking aspen leaves, from juvenile growth

  4. Huntington's disease: underlying molecular mechanisms and emerging

    E-Print Network [OSTI]

    Morimoto, Richard

    transcriptional mechanism also dictates the expression of polygluta- mine proteins. Here, we summarize the key with no disease modifying treatments available [1]. At the molecular level, HD is caused by a CAG trinu- cleotide is composed of proteins involved in transcription, DNA maintenance, cell cycle regulation, cellular orga

  5. News you can use Disease management

    E-Print Network [OSTI]

    Isaacs, Rufus

    DISEASE MANAGEMENT PAGE 9 CALENDAR A u g u s t 2 5 , 2 0 1 0 V O L 1 , I S S U E 1 5 A Michigan State. Elm Valley Road in Suttons Bay. Speaker: Rufus Isaacs will discuss late-season insect management. More

  6. Major Oak Diseases and Their Control.

    E-Print Network [OSTI]

    Johnson, Jerral D.; Appel, David N.

    1984-01-01T23:59:59.000Z

    Station, Texas (Blaok Page bl-?OriglulBidletial? / . , ,;..,' ,- ; ~ ~ " trees of Texas and are also... important components of forests and rangelands. They are normally long-lived, possess the ability to withstand adverse weather and have been considered disease resistant. During the drought in the mid 1950s large expanses of oak trees began dying...

  7. DISEASE-SPECIFIC PROBABILISTIC BRAIN ATLASES

    E-Print Network [OSTI]

    Thompson, Paul

    algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining School of Medicine, Los Angeles, CA 2 Alzheimer's Disease Center, UCLA School of Medicine, Los Angeles Westwood Plaza, Los Angeles, CA 90095-1769 Phone: (310) 206-2101 Fax: (310) 206-5518 E-mail: thompson

  8. Osteoporosis Osteoporosis is a disease character-

    E-Print Network [OSTI]

    SS-167-R05 Osteoporosis Osteoporosis is a disease character- ized by structural deterioration of bone tissue, leading to fragile bones and low bone mass. Osteoporosis can weaken bones and cause them" because bone loss occurs with- out symptoms. Many people may not know that they have osteoporosis until

  9. INFLAMMATORY BOWEL DISEASE: THE INSIDE DISH

    E-Print Network [OSTI]

    Stanford, Kyle

    to be aware of advances that can improve quality of life. UC Irvine Healthcare's H.H. Chao Comprehensive Center at UC Irvine Medical Center. Patients with Crohn's disease or ulcerative colitis benefit from 101 Jocelyne Miller, MD Medication Fix ­ Overview of Medical Treatments Nimisha K. Parekh, MD, MPH

  10. DISEASES OF AQUATIC ORGANISMS Dis Aquat Org

    E-Print Network [OSTI]

    Nizet, Victor

    ), and hybrid striped bass (Evans et al. 2000). Clinical symptoms of S. iniae infection in fish include loss from the freshwater dolphin Inia geoffrensis (Pier & Madin 1976), S. iniae infects a wide range of fish infection in humans who have handled diseased fish (Weinstein et al. 1997). Despite the need for novel

  11. Motor Control Abnormalities in Parkinson's Disease

    E-Print Network [OSTI]

    Motor Control Abnormalities in Parkinson's Disease Pietro Mazzoni, Britne Shabbott, and Juan Camilo Corte´s Motor Performance Laboratory, The Neurological Institute, Columbia University, New York, New. Motor symptoms can also be described in terms of motor control, a level of description that explains how

  12. What You Should Know About Plant Diseases.

    E-Print Network [OSTI]

    Horne, C. Wendell; Smith, Harlan E.

    1962-01-01T23:59:59.000Z

    . From 1845 to 1860, plant disease caused a disaster in Irelantl. Late blight struck the potato- yrowing region and turned the fields into a black- ened, rotting mass. A million people diet1 because I the potato crop failed; numerous families.... OTHER CONDITIONS WHICH MAY CAUSE PLANT IN JURY 1. Drying winds 2. Excessive light 3. Excessive lime in the soil 4. Over-use of commercial fertilizer 5. Gas injury PARASITIC OR SAPROPHYTIC PLANTS MISTLETOE-Mistletoe is a parasitic flowering plant...

  13. Soil Fumigation for Plant Disease Control.

    E-Print Network [OSTI]

    Young, P. A. (Paul Allen); Godfrey, G. H. (George Harold)

    1943-01-01T23:59:59.000Z

    satisfactory results were secured wikh xylene, ethylene dichloride, sodium cyanide and formaldehyde. Paper impregnated wit11 hoof-and-horn glue, casein glue, or vegetttble paste, and adequately sealed at the edges, was most satisfactory for con- fining... of the fumigants were effec- tive when the funligants were tightly confined in the soil. Soil fumigation boxes, made gas-tight by glueing the boards together and sealing the cover, were very effective for confining fumeants to kill plant-disease fungi and other...

  14. Characterization of a Drosophila model of Huntington's disease

    E-Print Network [OSTI]

    Lee, Wyan-Ching Mimi

    2006-01-01T23:59:59.000Z

    Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

  15. Women and Heart Disease: Neglected Directions for Future Research

    E-Print Network [OSTI]

    Barrett-Connor, Elizabeth

    2009-01-01T23:59:59.000Z

    009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

  16. Bleb Point: Mimicker of Pneumothorax in Bullous Lung Disease

    E-Print Network [OSTI]

    Gelabert, Christopher; Nelson, Mathew

    2015-01-01T23:59:59.000Z

    G, Biderman P, et al. “The lung point”: an REFERENCESof cystic and bullous lung disease. Chest Surg Clin N Am.S, Kaiser LR. Giant bullous lung disease: chest radiography

  17. alberta kidney disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for nearly 44 percent of new cases.1 Even when diabetes is controlled, the disease can lead to CKD Baker, Chris I. 2 Kidney Dysplasia National Kidney and Urologic Diseases...

  18. asbestos induced diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease in a patient may be a marker for disease in household contacts. Patients with family members heavily exposed to asbestos should be strongly encouraged to quit smoking in...

  19. animal virus diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  20. animal disease models: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  1. Should we expect population thresholds for wildlife disease?

    E-Print Network [OSTI]

    Getz, Wayne M.

    of Zoology and Entomology, University of Pretoria, 0002 South Africa 6 Energy and Resources Group, University , Adam B. Smith6 and Andrea Swei4 1 Department of Environmental Science, Policy and Management of infectious disease are core concepts of disease ecology and underlie disease control policies based

  2. Understanding Equine Strangles: Signs of Disease, Management and Prevention1

    E-Print Network [OSTI]

    Watson, Craig A.

    in 1251. The infection is highly contagious in horse populations and can recur on farms with previous outbreaks of the disease. It is one of the most commonly diagnosed contagious diseases of the horse signs of infection. Complications of Disease Fortunately, although strangles is highly contagious

  3. A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN

    E-Print Network [OSTI]

    A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN BY R. R. RUCKER, W. J. WHIPPLE, J. R A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN By R. R. Rucker, W. J. Whipple, J. R. Parvin and C. A #12;A CONTAGIOUS DISEASE OF SALMON, POSSIBLY OF VIRUS ORIGIN By R. R. Rucker,! Fishery Research

  4. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  5. New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc

    E-Print Network [OSTI]

    Corona, C; Pensalfini, A; Frazzini, V; Sensi, S L

    2011-01-01T23:59:59.000Z

    39;s disease: brain deregulation of calcium and zinc [39;s disease: brain deregulation of calcium and zinc39;s disease: brain deregulation of calcium and zinc Gotz

  6. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01T23:59:59.000Z

    predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

  7. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01T23:59:59.000Z

    in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang •

  8. Visualizing Brain Metals in Health and Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrincetonUsing Maps1 -Visualizing Brain Metals in Health and Disease

  9. Genetic Contributions to Infectious Disease Risk Infectious disease in cattle production

    E-Print Network [OSTI]

    Life Research, Texas A&M University, West· Texas A&M University, Texas Tech University, and USDA associated with disease resistance. Researchers at Texas AgriLife Research are well positioned to address collaborations including scientists in the College of Veterinary Medicine and Bio- medical Sciences at Texas A

  10. american registry home: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    management), power line (line connecting to multiple homes, routers can be shared. Home 1 Smart meter Utility Wang, Yubo 2012-01-01 90 LEED for Homes Program Review CiteSeer...

  11. animal tumour registry: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and sup 1 sup 5 sup 3 Sm-labelled as potential radioimmunotherapy (RIT) radiopharmaceuticals. A variety of malignant tumours over-express somatostatin receptors, proteins...

  12. Piloting an E-journals Preservation Registry Service (PEPRS) 

    E-Print Network [OSTI]

    Burnhill, Peter; Guy, Fred

    2010-04-09T23:59:59.000Z

    education in the UK, based at the University of Edinburgh, has been funded by the Joint Information Systems Committed (JISC) to carry out the work in partnership with the International Standard Serial Number International Centre (ISSN IC) in Paris...

  13. Beryllium-Associated Worker Registry Data Collection and Management Guidance

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureCommentsEnergy Christopher| Department ofBeowaweBeryllium

  14. Beryllium-Associated Worker Registry | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:WhetherNovember 13, 2009OakDepartment ofThe employment andBerkeleyThe

  15. DOE Strengthens Public Registry to Track Greenhouse Gas Emissions |

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613PortsmouthBartlesvilleAbout »DepartmentLaboratory | DepartmentCoal

  16. Radiological Source Registry and Tracking (RSRT) | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM615_CostNSAR - TProcuring SolarNo.Frequency |Department

  17. Safety Software Quality Assurance - Central Registry | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM615_CostNSARDevelopmental AssignmentAprilANDSafety Software Quality

  18. 2012 Beryllium-Associated Worker Registry Summary | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015ofDepartment ofCBFO-13-3322(EE) | Department1TheDepartment of

  19. 2013 Beryllium-Associated Worker Registry Summary | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you're a homeZappos.comThe Office of ElectricityDepartmentApril

  20. ORISE: Worker Health Studies - Beryllium Associated Worker Registry (BAWR)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated CodesTransparencyDOENurseResourcesThe Value The U.S. DepartmentWorkOak

  1. DOE Strengthens Public Registry to Track Greenhouse Gas Emissions |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: Theof"WaveInteractions andDefinition oftheLighting Inventory Survey

  2. 2011 Beryllium-Associated Worker Registry Summary | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of BadTHE U.S.Energy MoreEnergy back_cover.pdf More

  3. Beryllium-Associated Worker Registry - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced Materials Find MoreLawrence Berkeley Industrial Hygiene

  4. Beryllium-Associated Worker Registry Data Collection and Management Guidance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced Materials Find MoreLawrence Berkeley Industrial

  5. Automated diagnostic kiosk for diagnosing diseases

    DOE Patents [OSTI]

    Regan, John Frederick; Birch, James Michael

    2014-02-11T23:59:59.000Z

    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  6. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01T23:59:59.000Z

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  7. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01T23:59:59.000Z

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's pneumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  8. Optical detection dental disease using polarized light

    DOE Patents [OSTI]

    Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Fried, Daniel (San Francisco, CA)

    2003-01-01T23:59:59.000Z

    A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.

  9. Chronic Beryllium Disease Prevention Program Report

    SciTech Connect (OSTI)

    Lee, S

    2012-03-29T23:59:59.000Z

    This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

  10. Does aluminum smelting cause lung disease

    SciTech Connect (OSTI)

    Abramson, M.J.; Wlodarczyk, J.H.; Saunders, N.A.; Hensley, M.J.

    1989-04-01T23:59:59.000Z

    The evidence concerning a relationship between work in the aluminum industry and lung disease has been reviewed using epidemiologic criteria. Adequate data on environmental exposure are rarely presented. Case series on aluminum potroom workers over the past 50 years have identified an asthmalike syndrome that appears to be due to an irritant rather than an allergic mechanism. These studies have been supported by evidence of within shift variability of measures of lung function. However, to date, there is inadequate evidence to resolve the question of whether potroom exposure initiates asthma or merely precipitates asthmalike symptoms in a predisposed individual. Cross-sectional studies have demonstrated evidence of reduced lung function, consistent with chronic airflow limitation. In exposed aluminum smelter workers compared to unexposed control subjects. Cigarette smoking, the major potential confounding variable, has been measured and accounted for in multivariate analyses. To date, evidence is lacking from longitudinal studies about the development of disabling chronic obstructive lung disease. Exposure to coal tar pitch volatiles in the production and consumption of anodes has biologic plausibility for an association of lung cancer with work in an aluminum smelter. Although retrospective mortality studies have failed to account for the probable high prevalence of smoking in blue collar workers, the relative risk of lung cancer is very low if present at all. Pulmonary fibrosis has not been shown to be a significant problem in aluminum smelter workers. Future research in the aluminum industry needs to concentrate on longitudinal studies, preferably with an inception cohort for the investigation of potroom asthma. 92 references.

  11. Thiacetarsamide therapy of heartworm disease in cats: a pharmacokinetic study

    E-Print Network [OSTI]

    Turner, Janet Lynn

    1988-01-01T23:59:59.000Z

    . Coughing and exerci se intolerance are common clinical signs. Coughing may be related to the severe pulmonary arterial disease or may be due to pneumonitis induced by the heartworm ~nfection. Severe cases of dirofilariasis may have hemoptysis... intermittent coughing and dyspnea, as well as anorexia and vomiting. Necropsies of cats with heartworm disease usually demonstrate a low worm burden. ' Cardiomegaly is less common in cats than in 23, 30-34 dogs with heartworm disease. Pulmonary arterial...

  12. avium complex disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Characterizing SNP-Disease Associations Using Bayesian Networks University of Kansas - KU ScholarWorks Summary: of computational methods in epistatic interaction...

  13. aleutian mink disease virus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

  14. aleutian disease virus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

  15. asbestos-related pleuropulmonary diseases: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  16. adnexal diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  17. anus diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  18. assessing disease activity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    marked geographic clustering, and lack of reliable data on incidence, duration, and impact of the various disease syndromes. Non-health effects such as impoverishment,...

  19. adult kawasakis disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    association. Renee D. Goodwin; Daniel S. Pine 24 MRI-based Three dimensional shape analysis of thigh muscles: people with Chronic Obstructive Pulmonary Disease versus healthy...

  20. Genomics of emerging infectious disease: A PLoS collection.

    E-Print Network [OSTI]

    Eisen, Jonathan A; MacCallum, Catriona J

    2009-01-01T23:59:59.000Z

    Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

  1. Recombinant herpes simplex virus useful for treating neoplastic disease

    DOE Patents [OSTI]

    Whitley, Richard J.; Roizman, Bernard

    2010-06-29T23:59:59.000Z

    Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.

  2. Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model

    E-Print Network [OSTI]

    Treusch, Sebastian

    2011-01-01T23:59:59.000Z

    Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

  3. Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?

    E-Print Network [OSTI]

    Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

    2011-01-01T23:59:59.000Z

    case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

  4. Diseases of plantation forestry trees in eastern and southern Africa

    E-Print Network [OSTI]

    Diseases of plantation forestry trees in eastern and southern Africa J. Roux a*, G. Meke b , B are being allocated to the training of forestry staff andtreeimprovement.Theseefforts,aimedatstrengtheningthe forestry business, also embrace research on pests and diseases that might significantly reduce the value

  5. Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives

    SciTech Connect (OSTI)

    Mostafalou, Sara; Abdollahi, Mohammad, E-mail: Mohammad.Abdollahi@UToronto.Ca

    2013-04-15T23:59:59.000Z

    Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action. - Highlights: ? There is a link between exposure to pesticides and incidence of chronic diseases. ? Genotoxicity and proteotoxicity are two main involved mechanisms. ? Epigenetic knowledge may help diagnose the relationships. ? Efficient policies on safe use of pesticides should be set up.

  6. Motor signs during the course of Alzheimer disease

    E-Print Network [OSTI]

    to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits

  7. Harnessing plasticity to understand learning and treat disease

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Harnessing plasticity to understand learning and treat disease Michael P. Kilgard The University, USA A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies sug- gest that cortical map plasticity is typically a transient phase that improves

  8. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  9. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  10. Asbestos-related pulmonary disease in boilermakers

    SciTech Connect (OSTI)

    Demers, R.Y.; Neale, A.V.; Robins, T.; Herman, S.C. (Wayne State Univ., Detroit, MI (USA))

    1990-01-01T23:59:59.000Z

    Boilermakers are skilled building tradesmen who construct, repair, and dismantle boilers. The present study reports on the evaluation of members of a Michigan boilermaker's union for the presence of signs and symptoms of chronic pulmonary disease. Study variables included standardized evaluations of chest x-ray findings, pulmonary function testing, physical examination, and respiratory symptoms. An overall participation rate of 69% was achieved. A non-participant survey identified no significant differences between participants and non-participants in dyspnea, cough, age, or smoking history. Among participants with greater than 20 years experience in the trade, the mean FVC was 91% of predicted; the FEV1 was 86% of predicted; 25% showed at least a 1/0 profusion of interstitial markings on chest x-ray; 30% had bilateral pleural abnormalities; and 52% had audible inspiratory rales on physical examination. Forced vital capacity and forced expiratory volume at one second both decreased with years in the trade. Chest x-ray findings of interstitial fibrosis and pleural plaques were related to ten or more years in the trade, as were respiratory symptoms of pulmonary rales, wheeze, and dyspnea.

  11. Genetic Studies of Complex Human Diseases: Characterizing SNP-Disease Associations Using Bayesian Networks

    E-Print Network [OSTI]

    Han, Bing; Chen, Xue-wen; Talebizadeh, Zohreh; Xu, Hua

    2012-12-17T23:59:59.000Z

    (Suppl 3):S14 http://www.biomedcentral.com/1752-0509/6/S3/S14 © 2012 Han et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2...) heuristic search method can solve the classical XOR (Exclusive or) pro- blem [14]. We apply the EpiBN method to simulated datasets based on four disease models and three real datasets: Age-related Macular Degeneration (AMD) dataset, late-onset Alzheimer...

  12. Quantum Leaps in Disease Detection Luis Garcia-Rubio, Ph.D.

    E-Print Network [OSTI]

    Meyers, Steven D.

    Quantum Leaps in Disease Detection Luis Garcia-Rubio, Ph.D. USF researchers are making quantum leaps in disease detection with the develop- ment of portable biosensors that can detect deadly diseases

  13. autoimmune disease triggered: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease (PD), to date there is still no definite cause or accepted treatment Hlava, Debbie Joy 2012-01-01 44 One (1) Postdoctoral position available at IMBB-FORTH, Heraklion,...

  14. artery disease results: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  15. artery disease evaluation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GIUSEPPE, RACHELE 2012-01-01 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  16. artery disease share: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    David Andrew 2007-01-01 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  17. artery disease combined: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 52 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  18. artery disease focus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  19. artery disease metabolismo: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 40 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  20. artery disease quantification: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  1. artery disease studied: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    pressure Hielscher, Andreas 8 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  2. artery disease selection: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Andrew J. Lees 1991-01-01 56 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  3. artery disease trial: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 50 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  4. arterial occlusive disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  5. artery disease potential: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    fo... Yi, Li Ting 2013-01-01 56 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  6. artery disease involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    E. Lundquist; James P. Ward 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  7. artery disease comparison: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 45 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  8. artery disease left: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Du Toit, Henning 2007-01-01 52 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  9. artery disease assessed: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  10. artery disease longitudinal: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 51 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  11. artery disease cad: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hanson, Stephen Jos 18 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  12. arterial occlusive diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  13. artery disease drugs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 74 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  14. artery disease outcomes: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  15. artery disease undergoing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 42 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  16. artery disease accuracy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 42 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  17. artery disease 24-month: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 40 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  18. artery disease assessment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  19. artery disease increased: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mervyn J. Monteiro 1997-01-01 52 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  20. artery occlusive disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  1. artery disease stroke: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A; Bachmann, Max O 2011-02-28 72 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  2. artery disease evaluated: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GIUSEPPE, RACHELE 2012-01-01 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  3. artery disease insights: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 50 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  4. arterial disease study: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    pressure Hielscher, Andreas 8 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  5. arterial disease severity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with chronic Roche, Benjamin 62 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  6. artery disease severity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with chronic Roche, Benjamin 62 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  7. artery disease subanalysis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 38 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  8. arterial disease lack: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 42 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  9. ameliorate coral disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Functionally diverse reef-fish communities ameliorate coral disease Biology and Medicine Websites Summary:...

  10. advanced hiv disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HIV-1 infection, with extremes of very rapid disease progression (,2 years) and long-term non-progression (.15 years). To reveal additional host genetic factors that may impact on...

  11. Medicating race : heart disease and durable preoccupations with difference

    E-Print Network [OSTI]

    Pollock, Anne, 1975-

    2007-01-01T23:59:59.000Z

    This dissertation is an examination of intersections of race, pharmaceuticals, and heart disease over the course of the 20th century and today. Each of these parts has had a dynamic history, and when they are invoked ...

  12. Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs

    E-Print Network [OSTI]

    Babu, M. Madan

    31st Jan 2011 Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs M. Madan ...........................................................................................................................................................................1 2. The need for regulating IDPs.................................................................................................................................................1 3. General principles of IDP regulation

  13. Striatal origin of the pathologic beta oscillations in Parkinson's disease

    E-Print Network [OSTI]

    Boyden, Edward Stuart

    Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...

  14. Modelling power-law spread of infectious diseases

    E-Print Network [OSTI]

    Meyer, Sebastian

    2013-01-01T23:59:59.000Z

    Short-time human travel behaviour can be well described by a power law with respect to distance. We incorporate this information in space-time models for infectious disease surveillance data to better capture the dynamics of disease spread. Two previously established model classes are extended, which both decompose disease risk additively into endemic and epidemic components: a space-time point process model for individual point-referenced data, and a multivariate time series model for aggregated count data. In both frameworks, the power-law spread is embedded into the epidemic component and its decay parameter is estimated simultaneously with all other unknown parameters using (penalised) likelihood inference. The performance of the new approach is investigated by a re-analysis of individual cases of invasive meningococcal disease in Germany (2002-2008), and count data on influenza in 140 administrative districts of Southern Germany (2001-2008). In both applications, the power-law formulations substantially ...

  15. A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE

    E-Print Network [OSTI]

    Newton, Billy W.

    2010-01-16T23:59:59.000Z

    Alcoholic steatosis (AS) is the initial pathology associated with early stage alcoholic liver disease and is characterized by the accumulation of fat in the liver. AS is considered clinically benign as it is reversible, as compared with alcoholic...

  16. Human alkaloid biosynthesis : chemical inducers of Parkinson's disease?

    E-Print Network [OSTI]

    Hatzios, Stavroula K. (Stavroula-Artemis K.)

    2005-01-01T23:59:59.000Z

    The occurrence of certain alkaloids in the human brain appears to be associated with the onset of Parkinson's disease (PD). Recently, a human protein bearing homology to an alkaloid synthase in plants was identified. This ...

  17. Real-time Raman system for in vivo disease diagnosis

    E-Print Network [OSTI]

    Motz, Jason T.

    Raman spectroscopy has been well established as a powerful in vitro method for studying biological tissue and diagnosing disease. The recent development of efficient, high-throughput, low-background optical fiber Raman ...

  18. Dopamine Release and Uptake in Animal Models of Neurological Diseases

    E-Print Network [OSTI]

    Fulks, Jenny Lynn

    Fast scan cyclic voltammetry (FSCV) can be utilized to detect neurotransmitter release and uptake in brain slices. When combining this technique with disease state animals models, information for therapeutic targets can ...

  19. Quantitative Neuroimaging : : Applications to Normal Aging and Neurodegenerative Disease

    E-Print Network [OSTI]

    Murphy, Elizabeth Ann

    and metabolism of lipoproteins. Ann Endocrinol 44(1), 59-65.Disease by Elizabeth Ann Murphy Doctor of Philosophy ina tale of two proteins. Ann Neurol. 2006;59(3);449-458.

  20. Huntington's Disease: Can Mice Lead the Way to Treatment?

    E-Print Network [OSTI]

    Crook, Zachary Ryan

    Mouse models for Huntington's Disease (HD) and HD patients demonstrate motor and behavioral dysfunctions, such as progressive loss of coordination and memory, and share similar transcriptional profiles and striatal neuron ...

  1. Array-based detection of genetic alterations associated with disease

    DOE Patents [OSTI]

    Pinkel, Daniel; Albertson, Donna G.; Gray, Joe W.

    2007-09-11T23:59:59.000Z

    The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases.

  2. A biophysical marker of severity in sickle cell disease

    E-Print Network [OSTI]

    Mahadevan, L.

    The search for predictive indicators of disease has largely focused on molecular markers. However, biophysical markers, which can integrate multiple pathways, may provide a more global picture of pathophysiology. Sickle ...

  3. Educational attainment and rate of cognitive decline in Alzheimer's disease

    E-Print Network [OSTI]

    Hemmy, Laura Sue

    2009-05-15T23:59:59.000Z

    Alzheimer’s disease (AD) progression and hypotheses of the cognitive reserve theory were investigated by testing for a relation between educational attainment and rate of decline in patients with Mild Cognitive Impairment, possible AD, probable AD...

  4. alzheimers disease neuroimaging: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Mathematics Websites...

  5. Timing of testing and treatment for asymptomatic diseases

    SciTech Connect (OSTI)

    K?rk?zlar, Eser [State Univ. of New York (SUNY), Plattsburgh, NY (United States); Faissol, Daniel M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Griffin, Paul M. [Pennsylvania State Univ., State College, PA (United States); Swann, Julie L. [Georgia Inst. of Technology, Atlanta, GA (United States)

    2010-07-01T23:59:59.000Z

    Many papers in the medical literature analyze the cost-effectiveness of screening for diseases by comparing a limited number of a priori testing policies under estimated problem parameters. However, this may be insufficient to determine the best timing of the tests or incorporate changes over time. In this paper, we develop and solve a Markov Decision Process (MDP) model for a simple class of asymptomatic diseases in order to provide the building blocks for analysis of a more general class of diseases. We provide a computationally efficient method for determining a cost-effective dynamic intervention strategy that takes into account (i) the results of the previous test for each individual and (ii) the change in the individual’s behavior based on awareness of the disease. We demonstrate the usefulness of the approach by applying the results to screening decisions for Hepatitis C (HCV) using medical data, and compare our findings to current HCV screening recommendations.

  6. 452 Plant Disease / Vol. 82 No. 5 A. R. Biggs

    E-Print Network [OSTI]

    Biggs, Alan R.

    452 Plant Disease / Vol. 82 No. 5 A. R. Biggs West Virginia University, Kearneysville G. G. Grove-illustrated "fact sheets" Dr. Biggs' address is: West Virginia University, University Experiment Farm, P. O. Box 609

  7. Nature of language impairment in motor neurone disease 

    E-Print Network [OSTI]

    Rewaj, Phillipa Jane

    2014-07-01T23:59:59.000Z

    Background: Language impairment associated with Motor Neurone Disease (MND) has been documented since the late 19th century, yet little is understood about the pervasiveness or nature of these deficits. The common clinical ...

  8. acute liver disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    primary biliary cirrhosis (PBC) are progressive autoimmune liver diseases (AiLD) that can lead to liver cirrhosis, hepatic (more) Ngu, Jing Hieng 2013-01-01 3 P ICHAI et al...

  9. RESEARCH OF ANIMAL DISEASE INFORMATION SYSTEM BASED ON GIS

    E-Print Network [OSTI]

    Boyer, Edmond

    RESEARCH OF ANIMAL DISEASE INFORMATION SYSTEM BASED ON GIS TECHNOLOGY Hongbin Wang *, Lin Li, Jing.1007/978-3-642-12220-0_9 #12;2 Hongbin Wang, Lin Li, Jing Dong, Danning Xu, Jing Li distribution. It is evident

  10. Disease Ecology: Community Structure and Pathogen Dynamics [Review

    E-Print Network [OSTI]

    Peterson, A. Townsend

    2007-01-01T23:59:59.000Z

    BOOKS & MEDIA Disease Ecology: Community Structure and Pathogen Dynamics Sharon K. Collinge and Chris Ray, editors Oxford University Press, Cary, North Carolina, 2006 ISBN: 0198567073 Pages: 227; Price: US $124.50 The disciplines of community...

  11. CENTERS FOR DISEASE CONTROL ,,~V'CIl'1I

    E-Print Network [OSTI]

    EXECUTIVESECRETARY Houk, Vernon N., M.D. Director Center for Environmental Health Centers for Disease Conlrol Atlanla Hahnemann UniversilY Broad and Vine Streets Philadelphia, Pennsylvania 19102 Cole, Jerome F., S

  12. Host nutrition and infectious disease: an ecological view

    E-Print Network [OSTI]

    Smith, Val H.; Jones II, Tyrees P.; Smith, Marilyn S.

    2005-06-01T23:59:59.000Z

    Nutrition is typically discussed in terms of maintaining a proper diet and avoiding nutrient deficiency diseases. However, nutrition can also be viewed from an ecological standpoint: mammalian hosts and their pathogens ...

  13. CORAL HEALTH AND DISEASE: A COMPARISON OF COOK’S AND ‘OPUNOHU BAYS IN MOOREA, FRENCH POLYNESIA

    E-Print Network [OSTI]

    Shea, Alessandra

    2011-01-01T23:59:59.000Z

    Predictive  Modeling  of  Coral  Disease  Distribution Baseline levels of coral disease  in  the  northwestern 2011.   Patterns  of  Coral  Disease  across  Hawaiian 

  14. Engineering disease resistance with pectate lyase-like genes

    DOE Patents [OSTI]

    Vogel, John; Somerville, Shauna

    2005-03-08T23:59:59.000Z

    A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

  15. Digital subtraction angiography in pediatric cerebrovascular occlusive disease

    SciTech Connect (OSTI)

    Faerber, E.N.; Griska, L.A.B.; Swartz, J.D.; Capitanio, M.A.; Popky, G.L.

    1984-08-01T23:59:59.000Z

    While conventional angiography has been used to demonstrate cerebrovascular occlusive disease in the past, digital subtraction angiography (DSA) is capable of showing progressive vascular involvement with ease, simplicity, and extremely low morbidity, making it particularly well suited for children and outpatients either alone or coordinated with computed tomography. The authors discuss the usefulness and advantages of DSA as demonstrated in 7 infants and children with hemiplegia, 4 of whom had sickle-cell disease.

  16. Field Diseases of the Sweet Potato in Texas.

    E-Print Network [OSTI]

    Taubenhaus, J. J. (Jacob Joseph)

    1919-01-01T23:59:59.000Z

    TEXAS AGRICULTURAL EXPERIMENT STATION AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS W. B. BIZZELL. President BULLETIN NO. 249 SEPTEMBER, 1919 DIVISION OF PLANT PATHOLOGY AND PHYSIOLOGY FIELD DISEASES OF THE SWEET POTATO IN TEXAS B. YOUNGBLO OD... Medicine. A: & M. College of Texas. 'In cooperatloll with the Unlted States Department of A,mculture. . tIn cooperation with School of Agriculture, A. & M. College of Texas. - BULLETIN NO. 249. SEPTEMBER, 1 919. FIELD DISEASES OF THE SWEET POTATO...

  17. Structural Genomics and Drug Discovery for Infectious Diseases

    SciTech Connect (OSTI)

    Anderson, W.F.

    2010-09-03T23:59:59.000Z

    The application of structural genomics methods and approaches to proteins from organisms causing infectious diseases is making available the three dimensional structures of many proteins that are potential drug targets and laying the groundwork for structure aided drug discovery efforts. There are a number of structural genomics projects with a focus on pathogens that have been initiated worldwide. The Center for Structural Genomics of Infectious Diseases (CSGID) was recently established to apply state-of-the-art high throughput structural biology technologies to the characterization of proteins from the National Institute for Allergy and Infectious Diseases (NIAID) category A-C pathogens and organisms causing emerging, or re-emerging infectious diseases. The target selection process emphasizes potential biomedical benefits. Selected proteins include known drug targets and their homologs, essential enzymes, virulence factors and vaccine candidates. The Center also provides a structure determination service for the infectious disease scientific community. The ultimate goal is to generate a library of structures that are available to the scientific community and can serve as a starting point for further research and structure aided drug discovery for infectious diseases. To achieve this goal, the CSGID will determine protein crystal structures of 400 proteins and protein-ligand complexes using proven, rapid, highly integrated, and cost-effective methods for such determination, primarily by X-ray crystallography. High throughput crystallographic structure determination is greatly aided by frequent, convenient access to high-performance beamlines at third-generation synchrotron X-ray sources.

  18. Non-Chemical Control of Plant Diseases in the Home Garden

    E-Print Network [OSTI]

    Philley, George L.; Kaufman, Harold W.

    2000-02-16T23:59:59.000Z

    Plant diseases can be caused by certain organisms or by environmental factors. This publication discusses non-chemical methods that suppress disease-causing organisms....

  19. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01T23:59:59.000Z

    United States White heart disease mortality rates by gender–year–years of education, ages 25–64 years Heart disease death rate*

  20. Utilization of Fibroblast Steroidogeic Capacity as a Predictive Marker for Alzheimer's Disease

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    the cause of AD must be related to aging · Figure 1. Sex Hormone Dyscrasia Following Menopause Post, including coronary heart disease, stroke, Alzheimer's disease and osteoporosis. Since circulating

  1. Rheumatic Heart Disease and Beta-hemolytic Streptococci in Salvador, Brazil: A Study of Slum Health

    E-Print Network [OSTI]

    Tartof, Sara Yee

    2010-01-01T23:59:59.000Z

    rheumatic fever and rheumatic heart disease in Africa. S Afrthe chain that links the heart to the throat? Lancet Infectchildren with rheumatic heart disease. J Thorac Cardiovasc

  2. Thoracic irradiation in Hodgkin's disease: Disease control and long-term complications

    SciTech Connect (OSTI)

    Tarbell, N.J.; Thompson, L.; Mauch, P. (Harvard Medical School, Boston, MA (USA))

    1990-02-01T23:59:59.000Z

    A total of 590 patients with Stage IA-IIIB Hodgkin's disease received mantle irradiation at the Joint Center for Radiation Therapy between April 1969 and December 1984 as part of their initial treatment. Recurrence patterns as well as pulmonary, cardiac and thyroid complications were analyzed. Pulmonary recurrence was more frequently seen in patients with large mediastinal adenopathy (LMA); 11% of patients with LMA recurred in the lung in contrast to 3.1% with small or no mediastinal disease, p = 0.003. Hilar involvement, when corrected for size of mediastinal involvement, was not predictive of lung relapse. Patients with LMA also had a high rate of nodal relapse above the diaphragm (40%) following radiation therapy (RT) alone as compared to similarly treated patients with small or no mediastinal adenopathy (6.5%), p less than 0.0001. This risk of nodal recurrence was greatly reduced (4.7%) for LMA patients receiving combined radiation therapy and chemotherapy (CMT), p less than 0.0001. Sixty-seven patients (11%) with hilar or large mediastinal involvement received prophylactic, low dose, whole lung irradiation. No decrease in the frequency of lung recurrence was seen with the use of whole lung irradiation. Radiation pneumonitis was seen in 3% of patients receiving radiation therapy alone. In contrast, the use of whole lung irradiation was associated with a 15% risk of pneumonitis, p = 0.006. The risk of pneumonitis was also significantly increased with the use of chemotherapy (11%), p = 0.0001. Cardiac complications were uncommon with pericarditis being the most common complication (2.2%). Thyroid dysfunction was seen in 25% of patients and appeared to be age-related. These data suggest that the long-term complications of mantle irradiation are uncommon with the use of modern radiotherapeutic techniques.

  3. Costs of chronic disease and an alternative to reduce these costs: case study of End Stage Renal Disease (ESRD)

    E-Print Network [OSTI]

    Jang, Won-Ik

    2005-02-17T23:59:59.000Z

    COSTS OF CHRONIC DISEASE AND AN ALTERNATIVE TO REDUCE THESE COSTS: CASE STUDY OF END STAGE RENAL DISEASE (ESRD) A Dissertation by WON-IK JANG Submitted to the Office of Graduate Studies of Texas A&M University in partial...) A Dissertation by WON-IK JANG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved as to style and content by...

  4. Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease

    E-Print Network [OSTI]

    Vaughan-Dark, Chelsea Ann

    2013-07-17T23:59:59.000Z

    , & Tennen, 2006). Therefore, HRQOL provides valuable information about patient outcomes in terms of successful adaptation to chronic illness (Livneh, 2001; Varni, Burwinkle, & Lane, 2005). Although HRQOL is a broad concept that may encompass a number...; Cortina, McGraw, deAlarcon, Rothenberg, & Drotar, 2010; Varni et al., 2006; Varni et al., 2007). Within the category of gastrointestinal disorders, Crohn?s disease and ulcerative colitis, two conditions subsumed under the overarching disease category...

  5. Association Between Celiac Disease and Iron Deficiency in Caucasians, but not Non-Caucasians

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    autoimmune gastritis, Helicobacter pylori and celiac diseaserole of celiac disease, helicobacter pylori, and autoimmune

  6. Curr Pharm Des . Author manuscript Bisphosphonates and bone diseases: past, present and future

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    involving excessive bone resorption which include post-menopausal osteoporosis, Paget s disease of bone

  7. Journal of Alzheimer's Disease xx (20xx) xxx DOI 10.3233/JAD-132483

    E-Print Network [OSTI]

    Mandal, Pravat K.

    and Alzheimer's Disease as isoprostanes, neuroprostanes, acrolein, and hydrox- ynonenal (HNE), have also been

  8. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The

    E-Print Network [OSTI]

    Hammock, Bruce D.

    Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease contributes to the development of coronary heart disease (CHD). Soluble epoxide hydrolase metabolizes as a potential cardiovascular disease- susceptibility gene. INTRODUCTION Coronary heart disease (CHD) is a major

  9. acetamide herbicide degradates: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of aquatic herbicide association with herbicide appli- cations. Applications of acrolein, copper sulfate, chelated copper, diquat 26 ATSDR Review of Gagetown Herbicide Spray...

  10. acid type herbicides: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of aquatic herbicide association with herbicide appli- cations. Applications of acrolein, copper sulfate, chelated copper, diquat 37 ATSDR Review of Gagetown Herbicide Spray...

  11. Compositions and Methods for the Treatment of Pierce's Disease

    DOE Patents [OSTI]

    Gupta, Goutam (Santa Fe, NM)

    2008-10-07T23:59:59.000Z

    Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

  12. K. A. Garrett and C. M. Cox. Applied biodiversity science: Managing emerging diseases in agriculture and linked natural systems using 1 ecological principles. Pages 368-386 in Infectious disease ecology: The effects of ecosystems on disease and of disease

    E-Print Network [OSTI]

    Garrett, Karen A.

    in agriculture and linked natural systems using 1 ecological principles. Pages 368-386 in Infectious disease in Agriculture and Linked Natural Systems Using Ecological Principles K. A. Garrett and C. M. Cox Summary particular crop species or genotypes are very common. Nonetheless, production agriculture is dominated

  13. Comparing Online Community Structure of Patients of Chronic Diseases

    E-Print Network [OSTI]

    Maddali, Hanuma Teja; Margolis, Peter

    2015-01-01T23:59:59.000Z

    In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.

  14. Review article Aujeszky's disease virus: opportunities and challenges

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Review article Aujeszky's disease virus: opportunities and challenges Federico A. ZUCKERMANN les réponses immunitaires humorale et cellulaire chez le porc ont été mises en évidence. Cet article infection in swine similar to that of herpes simplex virus (HSV) in man. ADV is a neuroinvasive virus

  15. PUBLICATION 600-080 Fish Health and Disease

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    PUBLICATION 600-080 Fish Health and Disease Striped bass (Morone saxitilis) and hybrid striped bass these fish are commonly raised in high densities under intensive aquaculture situations (e.g., cages, ponds of the viral, bacterial, fungal, and parasitic pathogens, but the fish become increasingly susceptible

  16. What college students should know about Meningococcal Disease

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    is relatively rare, occurring at a rate of less than 1 in 100,000 people in the United States. Q. Who is at risk in their throat or nose in a harmless state without developing an illness. Meningococcal bacteria are spread and death within a few hours. Q. How can meningococcal disease be prevented? A. A vaccine is available

  17. Invest in Your Bones Osteoporosis--The Silent Disease

    E-Print Network [OSTI]

    Invest in Your Bones Osteoporosis--The Silent Disease Leaflet 2 Osteoporosis, a painful of State Health Services, 2008). Osteoporosis is preventable and/or treatable. Accordingly, osteoporosis of height, and chronic back pain. Hip fracture, the most serious consequence of osteoporosis, threatens one

  18. Neurobiology of Disease Psychosine Accumulates in Membrane Microdomains in the

    E-Print Network [OSTI]

    Bongarzone, Ernesto R.

    Neurobiology of Disease Psychosine Accumulates in Membrane Microdomains in the Brain of Krabbe of GALC ( -galactosylceramidase) that leads to a progressive accumulation of some galactosyl-sphingolipids in the brain. We hypothesized that the accumulation of psychosine (galactosyl-sphingosine) in the TWI CNS may

  19. Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease

    E-Print Network [OSTI]

    Levenson, Robert W.

    Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease Madeleine instructed and spontaneous emotion regulation in patients with frontotemporal lobar degeneration (FTLD, N 32) unwarned without instructions to down-regulate, (b) warned without instructions to down-regulate, and (c

  20. Detecting Acromegaly: Screening for Disease with a Morphable Model

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    ridge, and cheek bones. The disease is often missed by physicians and progresses beyond where it might of Blanz and Vetter. The model parameters capture many features of the 3D shape of the subject's head from just a single photograph, and are used directly for classification. We report encouraging results

  1. A Unified Framework for MR Based Disease Classification

    E-Print Network [OSTI]

    Pohl, Kilian M.

    A Unified Framework for MR Based Disease Classification Kilian M. Pohl1,2 and Mert R. Sabuncu2 1-hippocampal gyrus. On this small size data set, our approach, which performs classification based on the MR images with the accuracy achieved by state-of-the-art techniques in schizophrenia MRI research. 1 Introduction Thanks to in

  2. HYGIENIC BEHAVIOR OF HONEY BEES IN RELATION TO CHALKBROOD DISEASE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    HYGIENIC BEHAVIOR OF HONEY BEES IN RELATION TO CHALKBROOD DISEASE Martha GILLIAM, Stephen TABER III classified as resistant or susceptible on the basis of good or poor hygienic behavior, respectively. Colonies colonies that exhibit poor hygienic behavior. Therefore, good hygienic behavior of bees aids in control

  3. Cerebral blood flow in sickle cell cerebrovascular disease

    SciTech Connect (OSTI)

    Huttenlocher, P.R.; Moohr, J.W.; Johns, L.; Brown, F.D.

    1984-05-01T23:59:59.000Z

    Cerebral blood flow (CBF) has been studied by the xenon-133 (/sup 133/Xe) inhalation method in 16 children with suspected sickle cell cerebrovascular disease. Abnormalities consisting of decreases in total, hemispheral, or regional CBF were found in 17 of 26 studies. Eleven studies performed immediately after stroke, transient ischemic attack, or depression of state of alertness showed abnormalities. In addition to confirming regional cerebrovascular insufficiency in children with stroke due to major cerebral artery occlusion, the method detected diffuse decrease in CBF in children with stupor, coma, and seizures who had normal angiographic findings. In contrast, six of seven studies obtained after exchange transfusion or during maintenance on hypertransfusion therapy showed normal findings. The difference between results in patients with acute neurologic disturbances and those receiving transfusion therapy was statistically significant (P less than .005). The data indicate that the /sup 133/Xe method reliably demonstrates cerebrovascular impairment in sickle cell disease. They also suggest that CBF changes in patients with sickle cell disease can be reversed by exchange transfusion and by hypertransfusion therapy. The /sup 133/Xe CBF method may be useful for following up children with sickle cell disease who are at high risk for recurrent stroke.

  4. Botryosphaeriaceae associated with Eucalyptus canker diseases in Colombia

    E-Print Network [OSTI]

    Botryosphaeriaceae associated with Eucalyptus canker diseases in Colombia By C. A. Rodas1,3 , B, Pretoria, 0002, South Africa; 3 Smurfit Carto´n de Colombia, Investigacio´n Forestal, Carrera 3 No. 10-36, Cali, Valle, Colombia. 4 E-mail: bernard.slippers@fabi.up.ac.za (for correspondence) Summary

  5. Cancer is a genetic disease1 . Although environmental

    E-Print Network [OSTI]

    Nowak, Martin A.

    Cancer is a genetic disease1 . Although environmental and other non-genetic factors have roles in many stages of tumorigenesis,it is widely accepted that cancer arises because of mutations in cancer,however,does not suffice to give rise to full-blown cancer.For progression towards malignancyandinvasion

  6. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    ) in five University-based AD centers in the United States and European Union. Four outcomes, assessed every index, and death. Using a standardized portion of the Unified PD Rating Scale (administered every 6 disease (AD). Methods: A total of 533 patients with AD at early stages (mean Folstein Mini-Mental State

  7. A Predator-Prey Model with Disease Dynamics Chris Flake

    E-Print Network [OSTI]

    Logan, David

    a diseased fish population and their predators. Analysis of the system is performed to determine among the Tilapia fish of the Salton Sea and their predator, the pelican. This model is of interest deaths not only among the fish themselves, but also in the pelican population. Studies have indicated

  8. Rapid communication Identification of a Crohn's disease specific

    E-Print Network [OSTI]

    Perreault, Jean-Pierre

    to be due to a combination of factors involving diet, genetic background, immunological responses presented antigen, in individuals with a particular genetic back- ground may be involved in the lack that of their respective proteins appear to be useful as specific markers for unequivocally distinguishing Crohn's disease

  9. Selection of a multiple disease resistant runner-type peanut

    E-Print Network [OSTI]

    Baring, Michael Robert

    2007-09-17T23:59:59.000Z

    Four F2:4 populations of peanut (Arachis hypogaea L.) resulting from the complex cross Tamrun 96 X Tx901639-3 X Sun Oleic 95R were grown in three disease nurseries over a 2 year period. Three separate selection techniques were applied to determine...

  10. Introduction The number of catalogued emerging infectious diseases (EIDs), and

    E-Print Network [OSTI]

    Sehgal, Ravinder

    ). Perhaps even more immediate than these other factors are the implications of large- scale deforestation on disease emergence. The global rate of tropical deforestation appears to be increasing readily; between of deforestation in parts of Africa are near 1% per year (FAO, 2009). Deforestation is also increasing in temperate

  11. Food, Poverty and Epidemic Disease, Edinburgh: 1840-1850 

    E-Print Network [OSTI]

    MacGillivray, Neil

    2004-01-01T23:59:59.000Z

    epidemic disease is studied, concentrating on the fever epidemics of 184 1- 44, 1847-49 and the cholera outbreak of 1848-49 but reviewing also the lesser epidemics of measles, whooping cough and scarlet fever. The history of the identification of typhus...

  12. Prediction and Informative Risk Factor Selection of Bone Diseases

    E-Print Network [OSTI]

    Zhang, Aidong

    data and use these integrated features to effectively predict osteoporosis and bone fractures. We; disease memory; osteoporosis; bone fracture. ! 1 INTRODUCTION Risk factor (RF) analysis based on patients on the study of osteoporosis and bone fracture prediction. Over the past few decades, osteoporosis has been

  13. alzheimer disease brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alzheimer disease brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the...

  14. alzheimers disease brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alzheimers disease brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the...

  15. Random Disease on the Square Grid J ozsef Balogh

    E-Print Network [OSTI]

    Balogh, Jozsef

    a disease process. The initial configuration is called contagious or successful if the corresponding) squares in a contagious configuration. The solution of the initial exercise is the following: Fact. [Folklore] G(n) = n. Proof. If we paint the squares of a diagonal black, it will be a contagious

  16. Structural Location of Disease-associated Single-nucleotide Polymorphisms

    E-Print Network [OSTI]

    Pervouchine, Dmitri D.

    Structural Location of Disease-associated Single-nucleotide Polymorphisms Nathan O. Stitziel1 , Yan-synonymous single-nucleotide polymorphism (nsSNP) of genes introduces amino acid changes to proteins, and plays reserved Keywords: single-nucleotide polymorphism; alpha shape; hidden Markov model; surface pockets

  17. Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data

    E-Print Network [OSTI]

    Li, Jing

    Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Shui Huang2 , Jing Li2 Recent advances in neuroimaging techniques provide great potentials for effective diagnosis of Alzheimer. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds

  18. National Center for Immunization and Respiratory Diseases No More Excuses

    E-Print Network [OSTI]

    Liblit, Ben

    to protect yourself and your family. If you miss getting your flu vaccine in the fall, make it a New Year Vaccine WrongThe flu (influenza) is a contagious disease which affects the lungs and can lead to serious protect against non-flu viruses. · Oryoumighthavebeenexposedtoflu after you got vaccinated but before

  19. Prevalence of chronic obstructive pulmonary disease in rural women of

    E-Print Network [OSTI]

    Silver, Whendee

    for refining disease burden assessments attributable to household biomass combustion Priscilla Johnson1 January and May 2007. COPD assessments were done using a combination of clinical examination spend !2 hours/day in the kitchen involved in cooking. Use of solid fuel was associated with higher risk

  20. AT A GLANCE....INSECTS AND DISEASE PROBLEMS THAT SHOULD BE CONSIDERED THIS PEST/DISEASE/CULTURE

    E-Print Network [OSTI]

    Goodman, Robert M.

    /DISEASE/CULTURE JULY 8- JULY 15 HARVEST JULY 15- JULY 22 HARVEST SPOTTED WING DROSOPHILA Lannate, Imidan, Malathion effective against aphids and maggot when possible. Monitor with traps, and use materials that are also effective against aphids and maggot when possible. BLUEBERRY MAGGOT See list from previous newsletter

  1. Allostatic load amplifies the effect of blood lead levels on elevated blood pressure among middle-aged U.S. adults: a cross-sectional study

    E-Print Network [OSTI]

    Zota, Ami R; Shenassa, Edmond D; Morello-Frosch, Rachel

    2013-01-01T23:59:59.000Z

    and Disease Registry: Toxicological profile for lead.Toxicological Profile for Lead. U.S: Department of HealthThe relationship betwen blood lead and blood pressure in the

  2. Unusual thoracic radiographic findings in children treated for Hodgkin's disease

    SciTech Connect (OSTI)

    Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.

    1986-06-01T23:59:59.000Z

    Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

  3. BONE LOSS IN RELATION TO HYPOTHALAMIC ATROPHY IN ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Loskutova, Natalia Y.

    2011-05-12T23:59:59.000Z

    considerable burden on the health system, patients, and caregivers. 1.2 Alzheimer’s Disease and Bone Loss Bone health is an important issue in aging and AD. Osteoporosis–related fractures are among the major health and socioeconomic concerns in aging... of bone fractures, and a determining factor in clinical diagnosis of osteoporosis (Ammann and Rizzoli 2003). Several studies in women suggest that low BMD is associated with poorer cognitive function and subsequent cognitive decline (Yaffe, Browner et al...

  4. Programming of cardiovascular disease across the life-course

    E-Print Network [OSTI]

    Blackmore, Heather L.; Ozanne, Susan E.

    2014-12-12T23:59:59.000Z

    is critical in defining an individual’s risk in later life. Left unresolved sub- clinical conditions manifest into diseases such as atherosclerosis, myocardial infarction, stroke and heart failure. Although adverse lifestyle choices in adulthood (poor diet... ]. Maternal protein restriction is one of the most widely studied models of maternal undernutrition and similarly to global caloric restriction, offspring of protein-restricted dams have been shown to have high blood pressure in adulthood [36-39]. However...

  5. Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

    E-Print Network [OSTI]

    Thompson, Paul

    Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla and Alzheimer's disease based on high resolution MRI at 3 Tesla. T1-weighted images were acquired from 19

  6. Innovative Alzheimer's disease clinical trial design in the coming age of biomarkers

    E-Print Network [OSTI]

    Hillerstrom, Hampus

    2008-01-01T23:59:59.000Z

    Alzheimer's disease (AD) is a field with huge unmet need and only a few symptomatic treatments with limited efficacy have been made available to patients. With the testing of disease-modifying drugs in recent years, the ...

  7. I N T H I S I S S U E Lyme disease communication

    E-Print Network [OSTI]

    I N T H I S I S S U E · Lyme disease communication to countryside users · Providing public benefits in private woodlands, causes of wildfires in South Wales and communicating animal disease (Lyme) risks

  8. Morphological, cellular and proteomic features of canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Han, Richard I-Ming

    2009-01-01T23:59:59.000Z

    Myxomatous mitral valve degeneration (MMVD) is the single most common cardiac disease of the dog, and is analogous to Mitral Valve Prolapse in humans. Very little is known about the aetiopathogenesis of this disease or ...

  9. Design of a numerical model for simulation of blood microcirculation and study of sickle cell disease

    E-Print Network [OSTI]

    Le Floch-Yin, François T. (François Thomas)

    2010-01-01T23:59:59.000Z

    Sickle cell disease is nowadays one of the most challenging blood diseases, where patients suffer from both chronic and acute episodes of painful medical conditions. In particular, unpredictable crises due to blood vessel ...

  10. A common allele on chromosome 9 associated with coronary heart disease

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    M. Appleyard, European Heart Journal 3, Suppl H. , H1 (associated with Coronary Heart Disease in whites. Minor9 associated with coronary heart disease Ruth McPherson 1* ,

  11. Correlation of Klebsiella pneumoniae Comparative Genetic Analyses with Virulence Profiles in a Murine Respiratory Disease Model

    E-Print Network [OSTI]

    Fodah, Ramy A.

    Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied ...

  12. Fluid and structural modeling of the disease-free and atherosclerotic human carotid bifurcation

    E-Print Network [OSTI]

    Younis, Hesham F. (Hesham Farouk)

    2002-01-01T23:59:59.000Z

    Cardiovascular disease is the leading cause of death in the United States. It claims more lives each year than the next 7 leading causes of death combined. Atherosclerosis is a major cause of cardiovascular disease and is ...

  13. Integrated training in Cardiovascular Diseases Sponsored by the Division of Cardiology

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    and interventional procedures such as percutaneous interventions such as angioplasty and stent placement Knowlton, Division Head I. Major Diseases 1. Coronary artery disease 2. Congestive Heart Failure 3. Cardiac

  14. Di#erential equation models for Aujeszky's Disease Virus (ADV) in Irish pig herds

    E-Print Network [OSTI]

    , Dublin City University, Dublin 9, Ireland Abstract Aujeszky's Disease virus, (ADV) is a contagious viral Aladar Aujeszky, when he distinguished psuedorabies from rabies [23]. Aujeszky's Disease is a contagious

  15. Micro-Simulations of Infectious Disease using Official Register Data The Case of Smallpox

    E-Print Network [OSTI]

    Boman, Magnus

    , for example. #12;Introduction Should an infection of a contagious disease occur, the potential threat must be seen as an example of a predominantly airborne, fairly contagious vaccine-preventable disease where

  16. Differential equation models for Aujeszky's Disease Virus (ADV) in Irish pig herds

    E-Print Network [OSTI]

    ) is a contagious viral disease that affects the cen- tral nervous system of almost all animals, but swine are its Aladar Aujeszky, when he distinguished psuedorabies from rabies [23]. Aujeszky's Disease is a contagious

  17. asian foot-and-mouth disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  18. attenuated foot-and-mouth disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  19. assess foot-and-mouth disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  20. Three surveillance systems for describing the spatial distribution of Johne's disease seropositivity in Texas cattle

    E-Print Network [OSTI]

    Pearce, Brielle H.

    2009-05-15T23:59:59.000Z

    distribution of Johne’s disease seropositvity, based on the three surveillance systems, confirmed our hypothesis that estimation of disease distribution is dependant upon the source of surveillance samples....

  1. Pharmacological Chaperone Design for Reducing Risk Factor of Parkinson’s Disease from Traditional Chinese Medicine

    E-Print Network [OSTI]

    Huang, Hung-Jin

    Dysfunction of ?-glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson’s disease occurrence. Pharmacological chaperone design has been used to ...

  2. Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics

    E-Print Network [OSTI]

    Warren, Andrew David

    With noncommunicable diseases (NCDs) now constituting the majority of global mortality, there is a growing need for low-cost, noninvasive methods to diagnose and treat this class of diseases, especially in resource-limited ...

  3. Ann Occup Hyg . Author manuscript Asbestos-related diseases in automobile mechanics

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Ann Occup Hyg . Author manuscript Page /1 7 Asbestos-related diseases in automobile mechanics Abstract Purpose Automobile mechanics have been exposed to asbestos number of automobile mechanics, little is known about the non-malignant respiratory diseases observed

  4. Research Summary Assessing and communicating animal disease risks for countryside users

    E-Print Network [OSTI]

    to the collection of available leaflets on Lyme disease and to analyse their content mco-supervise a RELU Ph

  5. Proposed measures for the control of three diseases of veterinary public health significance in Bolivia

    E-Print Network [OSTI]

    Justiniano, Mario Miguel

    1981-01-01T23:59:59.000Z

    designed to suppress or eradicate disease has been presented. Plans for the development of effective programs for control of foot-and-mouth disease, brucellosis, and rabies have been presented along with recom- mendations for utilizing a task force... manuscripts of my thesis. TABLE OF CONTENTS Page INTRODUCTION. REVIEW OF THE LITERATURE. Geography Topography. Demography. Livestock Production. 10 Foot-and-Mouth Disease. Veterinary Public Health Aspects of Foot-and-Mouth Disease. 12 Control...

  6. Cardiovascular Disease and Functional Foods: The Effect of Milk Derived Peptides on Hypertension

    E-Print Network [OSTI]

    Nottingham, University of

    1 Cardiovascular Disease and Functional Foods: The Effect of Milk Derived Peptides on Hypertension and Hypertension Cardiovascular disease (CVD) encompasses many conditions including coronary heart disease, heart attack (myocardial infarction), stroke and hypertension. In 2003, CVD accounted for 16.7 million

  7. "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2

    E-Print Network [OSTI]

    Watson, Craig A.

    VM85 "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2 1. This document is VM85 fish is generically referred to as "red sore disease." This problem usually occurs in the spring on their fish. Typically, "red sore disease" is caused by two organisms, Aeromonas hydrophila , a bacterium

  8. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort

    E-Print Network [OSTI]

    van Geen, Alexander

    13 million residents in the United States.1 Although the International Agency for Research on Cancer Death from cardiovascular disease. Results 198 people died from diseases of circulatory system, accounting for 43% of total mortality in the population. The mortality rate for cardiovascular disease

  9. Machine Learning Algorithms for Predicting Severe Crises of Sickle Cell Disease

    E-Print Network [OSTI]

    Emilion, Richard

    thalassemia, another inherited anemia). The eects of sickle cell disease vary greatly from one personMachine Learning Algorithms for Predicting Severe Crises of Sickle Cell Disease Clara Allayous of an acute splenic sequestration crisis (ASSC), a serious symptom of sickle cell disease (SCD). Precisely

  10. THe heartTruTH Heart disease is the #1 killer of

    E-Print Network [OSTI]

    Baker, Chris I.

    THe heartTruTH® #12;Heart disease is the #1 killer of women, but many women do not know they are at risk. The Heart Truth® campaign aims to give women a personal and urgent wake-up call about their risk of heart disease. The red Dress® is the national symbol for women and heart disease awareness introduced

  11. Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease

    E-Print Network [OSTI]

    Carbonell, Jaime

    Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease Selen Uguroglu and Jaime Pittsburgh, PA 15212 Abstract We investigate machine learning methods for diagnos- tic screening of heart disease. Coronary heart disease is the leading cause of death in the US, causing more deaths than all

  12. Checklist of Successful Health Plan Approaches to Heart Disease and Stroke Prevention

    E-Print Network [OSTI]

    Checklist of Successful Health Plan Approaches to Heart Disease and Stroke Prevention Yes at risk for heart disease, stroke, and related conditions and risk factors (e.g., routine screenings the health plan offer specialized disease management programs for members who have been diagnosed with heart

  13. Towards an Objective Assessment of Alzheimer's Disease: The Application of a Novel Evolutionary Algorithm

    E-Print Network [OSTI]

    Fernandez, Thomas

    the way out of a large building. It also affects the drawing of simple three- dimensional geometric shapes countries [4]. The disease occurs when the amyloid -protein forms miliary bodies (plaques) and dense bundles conclusions are drawn in Section 5. 2. ALZHEIMER'S DISEASE Alzheimer's disease (AD) is the most common form

  14. Heart . Author manuscript Effects of depressive symptoms and coronary heart disease and their

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Heart . Author manuscript Page /1 11 Effects of depressive symptoms and coronary heart disease separately in patients with coronary heart disease (CHD) and in populations healthy at study inception and CHD status. OBJECTIVE To examine effects of depressive symptoms and coronary heart disease

  15. The Diet-Heart Hypothesis: a critical appraisal of the relationship between diet and coronary artery disease

    E-Print Network [OSTI]

    Jurewitz, Daniel L

    2007-01-01T23:59:59.000Z

    for Prevention of Coronary Heart Disease. JAMA. 2002;288:M. Fish consumption and coronary heart disease mortality: aacid and risk of ischemic heart disease among women. Am J

  16. Congestive heart failure: treat the disease, not the symptom: return to normalcy/Part II--the experimental approach.

    E-Print Network [OSTI]

    Buckberg, Gerald D

    2007-01-01T23:59:59.000Z

    Title: Congestive heart failure: treat the disease not theTITLE: Congestive heart failure: treat the disease not theGD. Congestive heart failure: treat the disease, not the

  17. Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

    E-Print Network [OSTI]

    Lindquist, Susan

    Endogenous protein quality control machinery has long been suspected of influencing the onset and progression of neurodegenerative diseases characterized by accumulation of misfolded proteins. Huntington's disease (HD) ...

  18. A Table of Areas Under Disease Progress Curves. 

    E-Print Network [OSTI]

    Johnson, Dennis A.; Wilcoxson, Roy D.

    1980-01-01T23:59:59.000Z

    [Blank Page in Original Bulletin] A TABLE OF AREAS UNDER DISEASE PROGRESS CURVES Technical Bullet in Texas Agricultural Experiment Station Texas A & M University System- [Blank Page in Original Bulletin] A TABLE OF AREAS UNDER D I S E A S E... Chillicothe-Vernon, TX 76384; and Professor Department of Plant Pathology University of Minnesota St. Paul, MN 55108 A T a b l e o f A r e a s Under D i s e a s e P r o g r e s s Curves 3 Denn i s A. J o h n s o n and Roy D . \\ W i l c o x s o...

  19. Sorghum Ergot: New Disease Threat to the Sorghum Industry

    E-Print Network [OSTI]

    Krausz, Joseph P.; Isakeit, Thomas

    1998-07-20T23:59:59.000Z

    of the sorghum ergot pathogen and likely serves as an overwintering source of ergot inoculum in south Texas. E-461 6-98 Sorghum Ergot New Disease Threat to the Sorghum Industry *Extension Plant Pathologists, The Texas A&M University System. Newly formed honeydew... dripping from an infected panicle. Joseph Krausz and Thomas Isakeit* Ho w is it a Threat to Texas? Each f_lo wer infected with ergot represents a direct loss of one seed. Additional losses occur because the stickiness of infected panicles inter- feres...

  20. Commercial Pecans: Controlling Rosette, Diseases and Zinc Deficiency

    E-Print Network [OSTI]

    Lee, Thomas A.; Krausz, Joseph P.

    2006-04-13T23:59:59.000Z

    Company Rate/acre Diseases Remarks Abound Azoxystrobin Syngenta 6.21?2.3 oz Scab, anthracnose Maximum 1.16 qt/year. No more than 3 applications before switching fungicides. 7?21-day interval Sovran Kresoxim-methyl BASF Pre... 30 oz/season. Trifl oxystrobin No more than 3 applications at a time before alternating. 14- to 21-day interval Headline Pyraclostrobin BASF 6?7 oz/A Scab Maximum 4 applications/ season or max of 28 oz/ season...

  1. Development of Biomarkers for Chronic Beryllium Disease in Mice

    SciTech Connect (OSTI)

    Gordon, Terry

    2013-01-25T23:59:59.000Z

    Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an animal model which can be used for dissecting dose-response relationships and pathogenic mechanisms and for testing new diagnostic and treatment paradigms. We have created 3 strains of transgenic mice in which the human antigen-presenting moiety, HLA-DP, was inserted into the mouse genome. Each mouse strain contains HLA-DPB1 alleles that confer different magnitude of risk for chronic beryllium disease (CBD): HLA-DPB1*0401 (odds ratio = 0.2), HLA-DPB1*0201 (odds ratio = 15), HLA-DPB1*1701 (odds ratio = 240). Our preliminary work has demonstrated that the *1701 allele, as predicted by human studies, results in the greatest degree of sensitization in a mouse ear swelling test. We have also completed dose-response experiments examining beryllium-induced lung granulomas and identified susceptible and resistant inbred strains of mice (without the human transgenes) as well as quantitative trait loci that may contain gene(s) that modify the immune response to beryllium. In this grant application, we propose to use the transgenic and Â?normal inbred strains of mice to identify biomarkers for the progression of beryllium sensitization and CBD. To achieve this goal, we propose to compare the sensitivity and accuracy of the lymphocyte proliferation test (blood and bronchoalveolar lavage fluid) with the ELISPOT test in the three HLA-DP transgenic mice strains throughout a 6 month treatment with beryllium particles. Because of the availability of high-throughput proteomics, we will also identify changes in potential protein biomarkers in beryllium-treated mice. We will correlate these findings with the ability of the transgenic mice to develop a beryllium-specific adaptive immune response in blood and bronchoalveolar lavage (BAL) fluid. We will also determine whether beryllium-responsive CD4+ T cells in blood and BAL correlate with the onset of granuloma formation. Thus, we will provide the scientific community with biomarkers of sensitization and disease progression for CBD. These biomarkers will serve as critical tools for development of improved industrial hygiene and therapeutic interventions.

  2. Chronic Beryllium Disease Prevention Program (10 CFR 850) | Department of

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011AT&T, Inc.'sEnergyTexas1. Feedstock &Energy Chronic Beryllium Disease

  3. Heart DiseaseHeart Disease--Learn to Love YourLearn to Love Your Michael McKee, M.D.Michael McKee, M.D.

    E-Print Network [OSTI]

    Goldman, Steven A.

    Heart DiseaseHeart Disease-- Learn to Love YourLearn to Love Your HeartHeart Michael McKee, M.D.Michael McKee, M.D. March 19, 2010March 19, 2010 #12;GoalsGoals ·· Learn more about heart disease for yourself andLearn more about heart disease for yourself and for your studentsfor your students ·· Learn

  4. Bead-based microfluidic immunoassay for diagnosis of Johne's disease

    SciTech Connect (OSTI)

    Wadhwa, Ashutosh [University of Tennessee, Center for Wildlife Health, Department of Forestry; Foote, Robert [ORNL; Shaw, Robert W [ORNL; Eda, Shigetoshi [ORNL

    2012-01-01T23:59:59.000Z

    Microfluidics technology offers a platform for development of point-of-care diagnostic devices for various infectious diseases. In this study, we examined whether serodiagnosis of Johne s disease (JD) can be conducted in a bead-based microfluidic assay system. Magnetic micro-beads were coated with antigens of the causative agent of JD, Mycobacterium avium subsp. paratuberculosis. The antigen-coated beads were incubated with serum samples of JD-positive or negative serum samples and then with a fluorescently-labeled secondary antibody (SAB). To confirm binding of serum antibodies to the antigen, the beads were subjected to flow cytometric analysis. Different conditions (dilutions of serum and SAB, types of SAB, and types of magnetic beads) were optimized for a great degree of differentiation between the JD-negative and JD-positive samples. Using the optimized conditions, we tested a well-classified set of 155 serum samples from JD negative and JD-positive cattle by using the bead-based flow cytometric assay. Of 105 JD-positive samples, 63 samples (60%) showed higher antibody binding levels than a cut-off value determined by using antibody binding levels of JD-negative samples. In contrast, only 43-49 JD-positive samples showed higher antibody binding levels than the cut-off value when the samples were tested by commercially-available immunoassays. Microfluidic assays were performed by magnetically immobilizing a number of beads within a microchannel of a glass microchip and detecting antibody on the collected beads by laser-induced fluorescence. Antigen-coated magnetic beads treated with bovine serum sample and fluorescently-labeled SAB were loaded into a microchannel to measure the fluorescence (reflecting level of antibody binding) on the beads in the microfluidic system. When the results of five bovine serum samples obtained with the system were compared to those obtained with the flow cytometer, a high level of correlation (linear regression, r2 = 0.994) was observed. In a further experiment, we magnetically immobilized antigen-coated beads in a microchannel, reacted the beads with serum and SAB in the channel, and detected antibody binding to the beads in the microfluidic system. A strong antibody binding in JD-positive serum was detected, whereas there was only negligible binding in negative control experiments. Our data suggest that the bead-based microfluidic system may form a basis for development of an on-site serodiagnosis of JD. Key Words: Mycobacterium avium ssp. paratuberculosis, Johne s disease, microfluidics, lab-on-a-chip.

  5. Bisphosphonates and Bone diseases: past, present and future Bisphosphonates are stable analogues of the naturally-occuring inorganic

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    involving excessive bone resorption which include post-menopausal osteoporosis, Paget's disease of bone

  6. When you hear the term "heart disease," what's your first reaction? Like many women, you may think, "That's a

    E-Print Network [OSTI]

    Bandettini, Peter A.

    When you hear the term "heart disease," what's your first reaction? Like many women, you may think, "That's a man's disease." But here's The Heart Truth: Heart disease is the #1 killer of Latinas in the United States. Together with stroke, heart disease accounts for a third of all deaths among Latinas

  7. When you hear the term "heart disease," what is your first reaction? Like many women, you may think, "That's a

    E-Print Network [OSTI]

    Bandettini, Peter A.

    When you hear the term "heart disease," what is your first reaction? Like many women, you may think, "That's a man's disease." But here's The Heart Truth: Heart disease is the #1 killer of women in the United States. It is also a leading cause of disability among women. If you've got a heart, heart disease

  8. A Table of Areas Under Disease Progress Curves.

    E-Print Network [OSTI]

    Johnson, Dennis A.; Wilcoxson, Roy D.

    1980-01-01T23:59:59.000Z

    o n s d a r i n g t h e development o f t h e ep idemic . The v a l u e s f o r AUDPC a r e l i s t e d under t h e days between t h e o b s e r v a t i o n s o f d i s e a s e . Thus , from d i s e a s e s e v e r i t i e s t a... a i d o f t h e m o d i f i e d c o b b Scale (12). The rus t sever i tyda tawere converted Fig. 2 Disease Progress Curves of Three Winter Wheat Cultivars Infected with Puccinia recondita f. sp. tritici. - TAM W-101 - - - I 1 A 0 ~ i m e...

  9. Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease

    SciTech Connect (OSTI)

    Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

    1988-07-01T23:59:59.000Z

    The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

  10. Neurological Complications Following Endoluminal Repair of Thoracic Aortic Disease

    SciTech Connect (OSTI)

    Morales, J. P.; Taylor, P. R.; Bell, R. E.; Chan, Y. C. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Sabharwal, T. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom); Carrell, T. W. G. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Reidy, J. F. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom)], E-mail: John.Reidy@gstt.nhs.uk

    2007-09-15T23:59:59.000Z

    Open surgery for thoracic aortic disease is associated with significant morbidity and the reported rates for paraplegia and stroke are 3%-19% and 6%-11%, respectively. Spinal cord ischemia and stroke have also been reported following endoluminal repair. This study reviews the incidence of paraplegia and stroke in a series of 186 patients treated with thoracic stent grafts. From July 1997 to September 2006, 186 patients (125 men) underwent endoluminal repair of thoracic aortic pathology. Mean age was 71 years (range, 17-90 years). One hundred twenty-eight patients were treated electively and 58 patients had urgent procedures. Anesthesia was epidural in 131, general in 50, and local in 5 patients. Seven patients developed paraplegia (3.8%; two urgent and five elective). All occurred in-hospital apart from one associated with severe hypotension after a myocardial infarction at 3 weeks. Four of these recovered with cerebrospinal fluid (CSF) drainage. One patient with paraplegia died and two had permanent neurological deficit. The rate of permanent paraplegia and death was 1.6%. There were seven strokes (3.8%; four urgent and three elective). Three patients made a complete recovery, one had permanent expressive dysphasia, and three died. The rate of permanent stroke and death was 2.1%. Endoluminal treatment of thoracic aortic disease is an attractive alternative to open surgery; however, there is still a risk of paraplegia and stroke. Permanent neurological deficits and death occurred in 3.7% of the patients in this series. We conclude that prompt recognition of paraplegia and immediate insertion of a CSF drain can be an effective way of recovering spinal cord function and improving the prognosis.

  11. Dual-Energy CT Angiography in Peripheral Arterial Occlusive Disease

    SciTech Connect (OSTI)

    Brockmann, Carolin, E-mail: carolin.brockmann@rad.ma.uni-heidelberg.de; Jochum, Susanne; Sadick, Maliha [University of Heidelberg, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim (Germany); Huck, Kurt [University of Heidelberg, I. Medical Clinic, Medical Faculty Mannheim (Germany); Ziegler, Peter [University of Heidelberg, Department of Surgery, Medical Faculty Mannheim (Germany); Fink, Christian; Schoenberg, Stefan O.; Diehl, Steffen J. [University of Heidelberg, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim (Germany)

    2009-07-15T23:59:59.000Z

    We sought to study the accuracy of dual-energy computed tomographic angiography (DE-CTA) for the assessment of symptomatic peripheral arterial occlusive disease of the lower extremity by using the dual-energy bone removal technique compared with a commercially available conventional bone removal tool. Twenty patients underwent selective digital subtraction angiography and DE-CTA of the pelvis and lower extremities. CTA data were postprocessed with two different applications: conventional bone removal and dual-energy bone removal. All data were reconstructed and evaluated as 3D maximum-intensity projections. Time requirements for reconstruction were documented. Sensitivity, specificity, accuracy, and concordance of DE-CTA regarding degree of stenosis and vessel wall calcification were calculated. A total of 359 vascular segments were analyzed. Compared with digital subtraction angiography, sensitivity, specificity, and accuracy, respectively, of CTA was 97.2%, 94.1%, and 94.7% by the dual-energy bone removal technique. The conventional bone removal tool delivered a sensitivity of 77.1%, a specificity of 70.7%, and an accuracy of 72.0%. Best results for both postprocessing methods were achieved in the vascular segments of the upper leg. In severely calcified segments, sensitivity, specificity, and accuracy stayed above 90% by the dual-energy bone removal technique, whereas the conventional bone removal technique showed a substantial decrease of sensitivity, specificity, and accuracy. DE-CTA is a feasible and accurate diagnostic method in the assessment of symptomatic peripheral arterial occlusive disease. Results obtained by DE-CTA are superior to the conventional bone removal technique and less dependent on vessel wall calcifications.

  12. Standardization of a Pan-Specific Test for the Diagnosis of Lyme Disease in Veterinary Medicine 

    E-Print Network [OSTI]

    Mcgregor, Erin 1990-

    2012-04-30T23:59:59.000Z

    for the designation as UNDERGRADUATE RESEARCH SCHOLAR A Senior Scholars Thesis by ERIN MCGREGOR STANDARDIZATION OF A PAN-SPECIFIC TEST FOR THE DIAGNOSIS OF LYME DISEASE IN VETERINARY MEDICINE Approved by: Research Advisor: Maria... of Veterinary Medicine and Biomedical Sciences Texas A&M University Research Advisor: Dr. Maria Esteve-Gassent Department of Veterinary Pathobiology Lyme disease (LD) is the most prevalent tick borne disease in the US with a total of 22,572 confirmed...

  13. Characterization of the Meq oncoproteins of Marek's disease virus vaccine strain CVI988/Rispens

    E-Print Network [OSTI]

    Ajithdoss, Dharani K.

    2010-07-14T23:59:59.000Z

    the condition in four adult male chickens in 1907 (Biggs, 1961; Marek, 1907). He described the disease as a "polyneuritis" or a ?neuritis interstitialis?, characterized by paralysis of the legs and wings. Grossly, the sacral plexuses and spinal cords were... leukosis virus (Biggs, 1961; Campbel, 1961; Elermann, 1922). Based on susceptibility, organs afected, and histopathogenesis, the disease can be distinguished from lymphoid leucosis and a new name, Marek?s disease, was proposed (Biggs, 1961). Later...

  14. E-Print Network 3.0 - aggravated creutzfeldt-jacob disease Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Proteins are the workhorses of the body, and the enigmatic process... secrets of protein folding that could lead to improved diagnosis and treatment of diseases Source: Daggett,...

  15. Soil fungicides in relation to cotton seedling disease at various temperature levels

    E-Print Network [OSTI]

    Ranney, Carleton David

    1955-01-01T23:59:59.000Z

    to obtain controlled spacing an4 4epth of seed ?hon ylanting, ~, , ~ 18 Xllnotration of seedling disease grades. Xi No evidence of diseases' energed 2 Sprouted' no e?L'donee of disease; no ssLergenoe. 5 Lesion less than three nao in length? 4i Lesion... of disease. 2, Emerged; lesion lees than three nn. long. ~Eaepgedj le&oh learn Qlall I%a ss, 10$$, gl aineb io the non proprietary nano ef sino ?thglene bi sdithiooarhanate. 4. Knerged~ sevorelF lesiono4, but not girdle4. 5? Energed~ dea4 or girdling...

  16. Gist Memory in Alzheimer's Disease: Evidence From Categorized Pictures Andrew E. Budson

    E-Print Network [OSTI]

    Schacter, Daniel

    Gist Memory in Alzheimer's Disease: Evidence From Categorized Pictures Andrew E. Budson Edith of items (gist memory; Reyna & Brainerd, 1995; Schacter, Norman, & Koutstaal, 1998). We have argued

  17. Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  18. Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  19. Edge effects, not connectivity, determine the incidence and development of a foliar fungal plant disease.

    SciTech Connect (OSTI)

    Johnson, Brenda, L.; Haddad, Nick, M.

    2011-08-01T23:59:59.000Z

    Using a model plant-pathogen system in a large-scale habitat corridor experiment, we found that corridors do not facilitate the movement of wind-dispersed plant pathogens, that connectivity of patches does not enhance levels of foliar fungal plant disease, and that edge effects are the key drivers of plant disease dynamics. Increased spread of infectious disease is often cited as a potential negative effect of habitat corridors used in conservation, but the impacts of corridors on pathogen movement have never been tested empirically. Using sweet corn (Zea mays) and southern corn leaf blight (Cochliobolus heterostrophus) as a model plant-pathogen system, we tested the impacts of connectivity and habitat fragmentation on pathogen movement and disease development at the Savannah River Site, South Carolina, USA. Over time, less edgy patches had higher proportions of diseased plants, and distance of host plants to habitat edges was the greatest determinant of disease development. Variation in average daytime temperatures provided a possible mechanism for these disease patterns. Our results show that worries over the potentially harmful effects of conservation corridors on disease dynamics are misplaced, and that, in a conservation context, many diseases can be better managed by mitigating edge effects.

  20. Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

    E-Print Network [OSTI]

    2014-01-01T23:59:59.000Z

    Integrative Genomics Reveals Novel Molecular Pathways and7 | e1004502 Integrative Genomics of Coronary Artery Disease2012) Use of functional genomics to identify candidate genes

  1. Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo Study

    E-Print Network [OSTI]

    von Mühlen, D.; Allison, M.; Jassal, S. K.; Barrett-Connor, E.

    2009-01-01T23:59:59.000Z

    calcification and the risk of osteoporosis and fractures. Jarterial disease and osteoporosis in older adults: theassociation between PAD and osteoporosis and bone loss only

  2. Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification

    E-Print Network [OSTI]

    Tong, Lily Victoria

    2008-01-01T23:59:59.000Z

    Human societies face diverse health challenges including a rapidly aging population, rising incidence of metabolic disease, and increasing antibiotic resistance. These problems involve complex interactions between genes ...

  3. Modelling of Blood Diseases November 5-9, 2007, Lyon, France

    E-Print Network [OSTI]

    Maume-Deschamps, Véronique

    Workshop Modelling of Blood Diseases November 5-9, 2007, Lyon, France Scientific committee: M (CNRS) Topics: Blood coagulation Hemophilia Leukemia Atherosclerosis Stroke Angiogenesis Plenary

  4. Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population for Studies in Aging, Montreal, Quebec, Canada Abstract Background: Herpes Simplex Virus (HSV) infection has) Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort

  5. Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2

    E-Print Network [OSTI]

    Watson, Craig A.

    FA181 Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2 1. This document is FA181, one and marine fishes caused by infection with an iridovirus known as Lymphocystivirus or Lymphocystis disease does not cause significant mortalities, it does cause unsightly growths on fish that reduce

  6. Spatially Regularized Logistic Regression for Disease Mapping on Large Moving Populations

    E-Print Network [OSTI]

    Vucetic, Slobodan

    . Categories and Subject Descriptors H.2.8 [Database Management]: Database Apps--Data Mining General Terms, Movement trajectories, Spatial-temporal data mining, Regularization, Privacy. 1. INTRODUCTION Disease, forestry, ecology, astronomy, and archeology [3]. There are two major methods for disease mapping

  7. Naam: mw. prof. dr. ir. Y.T. van der Schouw Leeropdracht Chronic Disease Epidemiology

    E-Print Network [OSTI]

    Utrecht, Universiteit

    differ between men and women, and how menopause and estrogens might be involved in this risk difference against chronic diseases of aging, such as cardiovascular disease, breast cancer, osteoporosis diabetics have been submitted. The third and most important area is the role of menopause and estrogens

  8. The Factors of Chronic Kidney Disease: Diabetes, Hypertension, Smoking, Drinking, Betelnut Chewing

    E-Print Network [OSTI]

    Chen, Chaur-Chin

    The Factors of Chronic Kidney Disease: Diabetes, Hypertension, Smoking, Drinking, Betelnut Chewing CKD 75 CKD Abstract The risk factors of Chronic Kidney Disease (CKD), including diabetes risk factors in a population-based cohort. Compared with single risk factors, diabetes (odds ratio 1

  9. Patterns of health and disease have undergone dramatic transitions during human history, reflecting social and

    E-Print Network [OSTI]

    Vermont, University of

    of infectious disease and infant mortality decreased, lengthening life expectancy.At the same time,noninfectious chronic disease rose, accounting for a greater share of over- all mortality. Greater water and air dispersed into new habitats by phoresy (i.e.,one organism transporting another), flight, or wind, but human

  10. Losses and Impact Distribution and Impacts of Annosus Root Disease in Forests of the

    E-Print Network [OSTI]

    Standiford, Richard B.

    expanding root disease centers, in groups of various sizes, and as scattered individuals. Distribution impacts on resource and ecosystem values for a single site. Insofar as possible, the net effect in progressively expanding disease centers, in tree groups of various sizes, and in scattered individuals. One

  11. Speeding up disease extinction with a limited amount of vaccine M. Khasin,1

    E-Print Network [OSTI]

    Dykman, Mark

    studied in stochastic population dynamics. Spontaneous extinction of species is important alsoSpeeding up disease extinction with a limited amount of vaccine M. Khasin,1 M. I. Dykman,1 and B stable; disease extinction happens at random and requires a large fluctuation, which can come from

  12. The role of phenoloxidase suppression in QX disease outbreaks among Sydney rock oysters

    E-Print Network [OSTI]

    Raftos, David

    disease. Oysters from the same brood stock were harvested from QX prone and QX free growing areas over negative correlation between phenoloxidase activity and the intensity of parasitic infection ( p = 0 prevented effective management of QX disease in endemic areas. Current management regimes rely only

  13. Coronary Heart Disease: Overview #1 Killer in the U.S.

    E-Print Network [OSTI]

    Meagher, Mary

    #12;Coronary Heart Disease: Overview · #1 Killer in the U.S. · Accounts for more than one in five, the vessels that supply the heart · Disease process: coronary atherosclerosis (plagues in artery) involves flow, shortage of oxygen, pain that radiates across the chest and arms Myocardial infarction - heart

  14. Health Alert: Treating acid reflux disease Posted: Feb 6, 2008 03:03 PM CST

    E-Print Network [OSTI]

    Chiao, Jung-Chih

    Treating acid reflux disease Posted: Feb 6, 2008 03:03 PM CST Updated: Feb 6 Jiang Tang. Exciting news for patients like John who want to treat their nagging, reflux symptoms by Logan Smith 2/8/2008WIStv.com Columbia, SC: Health Alert: Treating acid reflux disease URL: http

  15. Monte Carlo Simulation of Alzheimer's Disease in the United States: 2010-2060

    E-Print Network [OSTI]

    Feres, Renato

    Monte Carlo Simulation of Alzheimer's Disease in the United States: 2010-2060 Michael Blech concerns facing the United States over the next 50 years. This progressive disease is currently the sixth on the United States population, and second, the simulation models both prevalence and mortality. Both

  16. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk

    E-Print Network [OSTI]

    Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA 2 Case Western Reserve Accepted 1 August 2006 Chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni) and mule deer

  17. A medical game changer New device shows early promise for detecting heart disease

    E-Print Network [OSTI]

    Minnesota, University of

    Fall 2012 A medical game changer New device shows early promise for detecting heart disease It as a functional test for people at high risk of developing heart disease, the leading cause of death in the United for enhancing auscultation (listening to heart sounds). Her husband, Robert Guion, was a convenient, good

  18. Endemic disease, awareness, and local behavioural response S. Funk , E. Gilad, V.A.A. Jansen

    E-Print Network [OSTI]

    and awareness spread at different velocities. & 2010 Elsevier Ltd. All rights reserved. 1. Introduction. These actions can change the transmission patterns of the disease in altering the rates of spread as well response to a disease carries elements of a contagious process itself. For people to react in some way

  19. Modeling Economic Resilience and Animal Disease Outbreaks in the Texas High Plains

    E-Print Network [OSTI]

    Lin, Hen-I

    2012-02-14T23:59:59.000Z

    Foot and Mouth Disease (FMD) could have a significant impact on the U.S. agriculture industry and the welfare of U.S. producers and U.S. consumers. In order to address the potential impact from animal disease outbreaks, this project is designed...

  20. 3 Model Organisms in the Study of Development and Disease ETHAN BIER AND WILLIAM MCGINNIS

    E-Print Network [OSTI]

    McGinnis, William

    and invertebrates. This ancestor can be imagined as an advanced worm-like or primitive shrimp-like creature which for identifying and understanding genes that are altered in heritable human diseases and (2) the functions of many and inverte- brates. A systematic analysis of human disease gene homologs in Drosophila supports this view

  1. Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed countries

    E-Print Network [OSTI]

    Cai, Long

    Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed in the lungs. However, characteristic to both forms of the disease is the airway- wall accumulation of T helper are expressed either by skin8 or lung epithelial cells and can influence the way in which epithelial cells

  2. Automated segmentation of lungs with severe interstitial lung disease in CT

    E-Print Network [OSTI]

    Automated segmentation of lungs with severe interstitial lung disease in CT Jiahui Wang Department: Accurate segmentation of lungs with severe interstitial lung disease ILD in thoracic computed tomography CT developed in this study a texture analysis-based method for accurate segmentation of lungs with severe ILD

  3. UPDATE ON THE POTATO PURPLE TOP DISEASE IN THE COLUMBIA BASIN J.E. MUNYANEZA1

    E-Print Network [OSTI]

    Pappu, Hanu R.

    UPDATE ON THE POTATO PURPLE TOP DISEASE IN THE COLUMBIA BASIN J.E. MUNYANEZA1 , J.M. CROSSLIN2 , A Washington State Potato Commission, Moses Lake, WA; 4 Oregon State University, Hermiston, OR; 5 Washington on the potato purple top disease in the Columbia Basin. In: Proceedings, 44th Annual Washington State Potato

  4. Asbestos-related diseases in automobile mechanics Jacques Ameille, MD1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Asbestos-related diseases in automobile mechanics Jacques Ameille, MD1 , Nicole Rosenberg, MD2-related diseases in automobile mechanics Corresponding author Jacques Ameille, MD, Unité de pathologie plaques, automobile mechanics, HRCT inserm-00671970,version1-20Feb2012 Author manuscript, published

  5. Metabonomic Profiling of TASTPM Transgenic Alzheimer's Disease Mouse Model

    SciTech Connect (OSTI)

    Hu, Zeping; Browne, Edward R.; Liu, Tao; Angel, Thomas E.; Ho, Paul C.; Chun Yong Chan, Eric

    2012-12-07T23:59:59.000Z

    Identification of molecular mechanisms underlying early stage Alzheimer’s disease (AD) is important for the development of new therapies against and diagnosis of AD. In this study, non-targeted metabotyping of TASTPM transgenic AD mice was performed. The metabolic profiles of both brain and plasma of TASTPM mice were characterized using gas chromatography-mass spectrometry and compared to those of wild type C57BL/6J mice. TASTPM mice were metabolically distinct compared to wild type mice (Q28 Y = 0.587 and 0.766 for PLS-DA models derived from brain and plasma, respectively). A number of metabolites were found to be perturbed in TASTPM mice in both brain (D11 fructose, L-valine, L-serine, L-threonine, zymosterol) and plasma (D-glucose, D12 galactose, linoleic acid, arachidonic acid, palmitic acid and D-gluconic acid). In addition, enzyme immunoassay confirmed that selected endogenous steroids were significantly perturbed in brain (androstenedione and 17-OH-progesterone) and plasma (cortisol and testosterone) of TASTPM mice. Ingenuity pathway analysis revealed that perturbations related to amino acid metabolism (brain), steroid biosynthesis (brain), linoleic acid metabolism (plasma) and energy metabolism (plasma) accounted for the differentiation of TASTPM and wild-type

  6. Health Detectives: Uncovering the Mysteries of Disease (LBNL Science at the Theater)

    ScienceCinema (OSTI)

    Bissell, Mina; Canaria, Christie; Celnicker, Susan; Karpen, Gary

    2014-05-06T23:59:59.000Z

    In this April 23, 2012 Science at the Theater event, Berkeley Lab scientists discuss how they uncover the mysteries of disease in unlikely places. Speakers and topics include: World-renowned cancer researcher Mina Bissell's pioneering research on the role of the cellular microenvironment in breast cancer has changed the conversation about the disease. How does DNA instability cause disease? To find out, Christie Canaria images neural networks to study disorders such as Huntington's disease. Fruit flies can tell us a lot about ourselves. Susan Celniker explores the fruit fly genome to learn how our genome works. DNA is not destiny. Gary Karpen explores how environmental factors shape genome function and disease through epigenetics.

  7. Delays in Reducing Waterborne and Water-related Infectious Diseases in China under Climate Change

    SciTech Connect (OSTI)

    Hodges, Maggie; Belle, Jessica; Carlton, Elizabeth; Liang, Song; Li, Huazhong; Luo, Wei; Freeman, Matthew C.; Liu, Yang; Gao, Yang; Hess, Jeremy; Remais, Justin V.

    2014-12-01T23:59:59.000Z

    Despite China’s rapid progress improving water, sanitation and hygiene (WSH) infrastructure and access, in 2011, 471 million people lacked access to improved sanitation, and 401 million people lacked access to household piped water. Infectious diseases are sensitive to changes in climate, particularly temperature, and WSH conditions. To explore possible impacts of climate change on these diseases in China in 2020 and 2030, we coupled estimates of the temperature sensitivity of diarrheal disease and three vector-borne diseases, temperature projections from global climate models using four emissions pathways, WSH-infrastructure development scenarios and projected demographic changes. By 2030, the projected impacts would delay China’s historically rapid progress toward reducing the burden of WSH-attributable infectious disease by 8-85 months. This developmental delay provides a key summary measure of the impact of climate change in China, and in other societies undergoing rapid social, economic, and environmental change.

  8. Development of a Discrete Spatial-Temporal SEIR Simulator for Modeling Infectious Diseases

    SciTech Connect (OSTI)

    McKenna, S.A.

    2000-11-01T23:59:59.000Z

    Multiple techniques have been developed to model the temporal evolution of infectious diseases. Some of these techniques have also been adapted to model the spatial evolution of the disease. This report examines the application of one such technique, the SEIR model, to the spatial and temporal evolution of disease. Applications of the SEIR model are reviewed briefly and an adaptation to the traditional SEIR model is presented. This adaptation allows for modeling the spatial evolution of the disease stages at the individual level. The transmission of the disease between individuals is modeled explicitly through the use of exposure likelihood functions rather than the global transmission rate applied to populations in the traditional implementation of the SEIR model. These adaptations allow for the consideration of spatially variable (heterogeneous) susceptibility and immunity within the population. The adaptations also allow for modeling both contagious and non-contagious diseases. The results of a number of numerical experiments to explore the effect of model parameters on the spread of an example disease are presented.

  9. Comparative Cost Analysis of Alternative Animal Tracing Strategies Directed Toward Foot and Mouth Disease Outbreaks in the Texas High Plains

    E-Print Network [OSTI]

    Looney, John C.

    2010-07-14T23:59:59.000Z

    The primary objective of this study is to evaluate the industry impact of a hypothetical Foot and Mouth Disease (FMD) outbreak in the Texas High Plains using alternative animal tracing levels. To accomplish this objective, an epidemiological disease...

  10. Tissue-engineered canine mitral valve constructs as In vitro research models for myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Liu, Mengmeng

    2014-11-28T23:59:59.000Z

    Myxomatous mitral valve disease (MMVD) is one of the most common degenerative cardiac diseases affecting humans and dogs; however, its pathogenesis is not completely understood. This study focussed on developing ...

  11. Large-scale epidemiological data on cardiovascular diseases and diabetes in migrant and ethnic minority groups in Europe 

    E-Print Network [OSTI]

    Rafnsson, Snorri B; Bhopal, Raj

    2009-01-01T23:59:59.000Z

    Data on differences by ethnicity in cardiovascular diseases (CVDs) and diabetes, reflecting the influence of diverse cultural, social and religious factors, are important to providing clues to disease aetiology and ...

  12. This information sheet is for the care and use of Sheep Potential Injury and Zoonotic Diseases: Sheep are large domestic

    E-Print Network [OSTI]

    Wood, Marcelo A.

    . Contagious Echthyma: (Orf) This poxviral disease is known as contagious ecthyma or soremouth in sheep. The disease in ruminants is contagious to humans and other animals. Infected sheep or goats are the source

  13. This information sheet is for the care and use of Goats Potential Injury & Zoonotic Diseases: Goats are more

    E-Print Network [OSTI]

    Wood, Marcelo A.

    -824-3757. Contagious Echthyma (Orf): This poxviral disease is known as contagious echthyma, or sore mouth in sheep. In ruminants, the disease is highly contagious to humans and other animals. Infected sheep or goats

  14. Quantifying the patient population of ultra-orphan diseases: a case study in X-Linked Hypohidrotic Ectodermal Dysplasia

    E-Print Network [OSTI]

    Hermann, Julie (Julie Lynn)

    2011-01-01T23:59:59.000Z

    Understanding the true incidence and prevalence of a disease has tremendous value for the biopharmaceutical industry, particularly for orphan diseases that affect a minority of the population (in the US, the definition of ...

  15. Integrating Heterogeneous Healthcare Datasets and Visual Analytics for Disease Bio-surveillance and Dynamics

    SciTech Connect (OSTI)

    Ramanathan, Arvind [ORNL] [ORNL; Pullum, Laura L [ORNL] [ORNL; Steed, Chad A [ORNL] [ORNL; Quinn, Shannon [University of Pittsburgh School of Medicine, Pittsburgh PA] [University of Pittsburgh School of Medicine, Pittsburgh PA; Chennubhotla, Chakra [University of Pittsburgh School of Medicine, Pittsburgh PA] [University of Pittsburgh School of Medicine, Pittsburgh PA; Parker, Tara L [ORNL] [ORNL

    2013-01-01T23:59:59.000Z

    n this paper, we present an overview of the big data chal- lenges in disease bio-surveillance and then discuss the use of visual analytics for integrating data and turning it into knowl- edge. We will explore two integration scenarios: (1) combining text and multimedia sources to improve situational awareness and (2) enhancing disease spread model data with real-time bio-surveillance data. Together, the proposed integration methodologies can improve awareness about when, where and how emerging diseases can affect wide geographic regions.

  16. Computed tomography of the spleen and liver in sickle cell disease

    SciTech Connect (OSTI)

    Magid, D.; Fishman, E.K.; Siegelman, S.S.

    1984-08-01T23:59:59.000Z

    The spleen was assessed in 10 patients with sickle cell disease studied with computed tomography (CT) for abdominal pain and/or unexplained fever. Patients with homozygous sickle cell anemia were found to have small, densely calcified spleens with occasional low-density infarcts. Five of six had hepatomegaly, and there was one case each of hepatic abscess, infarcts, and hemochromatosis. All patients with heterozygous sickle cell disease were found to have splenomegaly, with a variety of findings including acute hemorrhage, acute and chronic infarcts, rupture, and possible sequestration. It was concluded that CT is useful for evaluating the status of the spleen and liver in symptomatic patients with sickle cell disease.

  17. Effect of pre-harvest calcium chloride applications on fruit calcium level and post-harvest anthracnose disease of papaya

    E-Print Network [OSTI]

    Biggs, Alan R.

    -harvest anthracnose disease of papaya Babak Madani a,*, Mahmud Tengku Muda Mohamed a,**, Alan R. Biggs c , Jugah Kadir

  18. nature medicine volume 18 | number 4 | april 2012 475 Microfluidic chips promise better diagnosis for sickle cell disease

    E-Print Network [OSTI]

    Bhatia, Sangeeta

    for signs of the debilitating blood disease sickle cell anemia. Existing blood tests can accurately diagnose diagnosis for sickle cell disease As part of routine newborn screening programs, babies are checked predict the likelihood of clot formation, a dangerous complication of sickle cell disease. In one design

  19. Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell disease

    E-Print Network [OSTI]

    Boyer, Edmond

    and painful vaso-occlusive crises in children with sickle cell anemia and hemoglobin SC disease. Design with sickle cell anemia, but not in children with hemoglobin SC disease; 2) a higher steady-state red blood with hemoglobin SC disease and boys with sickle cell anemia. Conclusion: Our results indicate for the first time

  20. Integrated training in Lung Biology and Diseases Sponsored by the Division of Pulmonary and Critical Care Medicine

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    Integrated training in Lung Biology and Diseases Sponsored by the Division of Pulmonary Obstructive Pulmonary Disease (COPD, Emphysema) 3 Pulmonary Infections 4 Lung Cancer 5 Cystic Fibrosis 6 Lung Transplantation 7 Pulmonary Hypertension 8 Pulmonary Embolism 9 Occupational Lung Diseases 10 Airway Allergic

  1. Researchers' Attitudes Towards Data Discovery: Implications for a UCLA Data Registry

    E-Print Network [OSTI]

    Mandell, Rachel Alyson

    2012-01-01T23:59:59.000Z

    end of theory: the data deluge makes the scientific methodto harness the data deluge. Data management is thereforehas caused a scientific data deluge, which has shifted our

  2. One Chance in a Million: Altruism and the Bone Marrow Registry

    E-Print Network [OSTI]

    Bergstrom, Ted C; Garratt, Rod; Sheehan-Connor, Damien

    2008-01-01T23:59:59.000Z

    For patients with acute leukemia, long- term survival is 50-chemotherapy in acute myelogenous leukemia. New EnglandLong-term survival in acute myeloid leukemia. Cancer, [6

  3. One Chance in a Million: Altruism and the Bone Marrow Registry

    E-Print Network [OSTI]

    Bergstrom, Ted C; Garratt, Rod; Sheehan-Connor, Damien

    2008-01-01T23:59:59.000Z

    108 patients with acute lymphoblastic leukemia: favorablein adult acute lymphoblastic leukemia in ?rst completeadults with acute lymphoblastic leukemia in ?rst remission

  4. United States Transuranium and Uranium Registries (USTUR): De-identified Case Data

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    [Taken from http://www.ustur.wsu.edu/AboutUs/overview.html and from http://www.ustur.wsu.edu/Mission/index.html and from http://www.ustur.wsu.edu/DeidentifiedData/database.html

  5. National Human Radiobiological Tissue Repository (NHRTR) at the United States Transuranium and Uranium Registries

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The NHRTR, one component of the USTUR, contains frozen tissues, tissue solutions, microscope slides, and paraffin blocks that were collected by the USTUR at the autopsy of workers with documented intakes of plutonium, americium, uranium, and thorium. The samples are available to qualified scientists for further research. Thousands of frozen, ashed, dried, and plastic embedded bone samples from the radium studies carried out by Argonne National Laboratory, Argonne Cancer Research Hospital, the Massachusetts Institute of Technology, and the New Jersey Radium Research Project are available and linked by case number to de-identified, published case data. These data include the person's source of exposure (dial painter, therapeutic injection, etc.), estimated body burden, radiochemical results, and medical history. Other samples, including organs and whole body donations, have come from volunteer donors who were impacted by elements such as plutonium, throium, etc. See the USTUR website for information on how to apply for research samples or how to become a volunteer donor. [Information taken from http://www.ustur.wsu.edu/NHRTR/index.html#

  6. Study Protocol: The Back pain Outcomes using Longitudinal Data (BOLD) Registry

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    modeling for health economic evaluation. Oxford: OxfordSonnad SS, Polsky D: Economic evaluation in clinical trials.

  7. DOI: 10.1002/cphc.201300259 The Registry Index: A Quantitative Measure of Materials'

    E-Print Network [OSTI]

    Hod, Oded

    and spin-echo spectroscopy, have revealed impor- tant factors that govern friction and wear at dry 2376 CHEMPHYSCHEM REVIEWS #12;1. Introduction Tribology, the science of friction, wear, and lubrication (electro)mechanical de- vices is their high surface-to-volume ratio, which leads to severe friction

  8. DOI: 10.1002/ijch.201000052 Quantifying the Stacking Registry Matching in Layered

    E-Print Network [OSTI]

    Hod, Oded

    tool for interlayer interactions in complex layered systems. Keywords: bilayer graphene · corrugation, 50, 506 ­ 514 Full Paper O. Hod #12;lent bonds of graphene, the dominant interlayer interac- tions in graphite and in few-layered graphene (FLG) are dispersion forces. These, in turn, lead to an optimal AB

  9. The California Climate Action Registry: Development of methodologies for calculating greenhouse gas emissions from electricity generation

    E-Print Network [OSTI]

    2002-01-01T23:59:59.000Z

    simplified load duration curve (LDC). Table 2 compares thesefrom import totals. c The LDC approach could includeload duration curve (LDC), as many simulation models do (

  10. Coronary computed tomography angiography predicts subsequent cardiac outcome events: results of the Visipaque CCTA registry study.

    E-Print Network [OSTI]

    Budoff, MJ; Bloom, SA; Chow, BJ; Chandler, AB; Cole, JH

    2015-01-01T23:59:59.000Z

    Event CCTA= Coronary computed tomography angiography; MACE=CONFIRM (COroNary computed tomography angiography evaluationcalcium scoring and computed tomography angiography: current

  11. Compliance of clinical trial registries with the World Health Organization minimum data set: a survey

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    Moher 8 , Ida Sim 9 and Jimmy Volmink 10 Address: 1 ItalianIda Sim - sim@medicine.ucsf.edu; Jimmy Volmink -

  12. A MOLECULAR ANALYSIS OF PROTEIN TRAFFICKING IN THE VERTEBRATE RETINA: IMPLICATIONS FOR INTRAFLAGELLAR TRANSPORT AND DISEASE

    E-Print Network [OSTI]

    Krock, Bryan L.

    2010-07-14T23:59:59.000Z

    trafficking. However, it was unclear whether photoreceptor degeneration in this disease is cell-autonomous, due to defective opsin transport within the photoreceptor, or is noncell-autonomous and a secondary consequence of defective RPE. Utilizing...

  13. Genetic approaches to studying coronary heart disease in SR-BI/apoE double knockout mice

    E-Print Network [OSTI]

    Karackattu, Sharon Liz

    2006-01-01T23:59:59.000Z

    Coronary heart disease (CHD) is a major healthcare concern in both developed and developing nations. The principal cause of CHD is atherosclerosis, the buildup of fatty deposits in vessel walls. SR-BI/apoE double knockout ...

  14. artery disease hercet-study: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 38 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  15. artery disease sub-analysis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 38 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  16. Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

    E-Print Network [OSTI]

    Davidson, Robert

    This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular ...

  17. The Regulation of Growth Factor Signaling in Drosophila Development and Disease

    E-Print Network [OSTI]

    Lindner, Jonathan Ryan

    2012-02-14T23:59:59.000Z

    Developmental signaling pathways have many diverse roles throughout the life of an organism. The proper regulation of these pathways is essential for normal development, and misregulation can lead to diseases such as cancer. Heparan sulfate...

  18. Non-invasive assessment of ventilation maldistribution in lung disease using multiple breath inert gas washouts. 

    E-Print Network [OSTI]

    Horsley, Alex

    2009-01-01T23:59:59.000Z

    Clinical research in cystic fibrosis (CF) requires study endpoints that are sensitive to airways disease, repeatable and non-invasive. Despite significant advances in the treatment of CF, lung function assessments continue ...

  19. A study of motor control in healthy subjects and in Parkinson's disease patients

    E-Print Network [OSTI]

    Levy-Tzedek, Shelly

    2008-01-01T23:59:59.000Z

    Parkinson's disease (PD) is a primarily motor disorder which affects at least half a million people in the US alone. Deep brain stimulation (DBS) is a neurosurgical intervention by which neural structures are stimulated ...

  20. Interactogeneous: Disease Gene Prioritization Using Heterogeneous Networks and Full Topology Scores

    E-Print Network [OSTI]

    and associations from the STRING database, was used to prioritize genes for Parkinson's disease. This method/2007 to JPG; and project contract PTDC/EIA-EIA/111239/2009 to Neuroclinomics. The funders had no role in study

  1. Text-mining applied to autoimmune disease research: the Sjögren¿s syndrome knowledge base

    E-Print Network [OSTI]

    Gorr, Sven-Ulrik; Wennblom, Trevor J; Horvath, Steve; Wong, David TW; Michie, Sara A

    2012-01-01T23:59:59.000Z

    as: Gorr et al. : Text-mining applied to autoimmune diseaseARTICLE Open Access Text-mining applied to autoimmunein the field, we used text mining to generate the Sjögren’s

  2. New Treatments for Infrapopliteal Disease: Devices, Techniques, and Outcomes So Far

    SciTech Connect (OSTI)

    Bernstein, Ondina; Chalmers, Nicholas, E-mail: nicholas.chalmers@cmft.nhs.uk [Manchester Royal Infirmary, Department of Radiology (United Kingdom)

    2012-08-15T23:59:59.000Z

    The use of endovascular treatment of infrapopliteal disease has increased in popularity in recent years. An improvement in technical success rates due to the availability of newer devices has fuelled an increased interest in the subject. The pathogenesis, indications for treatment, and outcome measures of infrapopliteal disease differ from larger vessel intervention. Diabetes and renal failure are prevalent. Neuropathy and venous disease contribute to the etiology of ulceration. Most interventions are undertaken for critical limb ischemia rather than claudication. Therefore, a range of conservative, pharmacological, and invasive therapies are provided. Conventional percutaneous transluminal angioplasty (PTA) using modern low-profile systems is associated with high technical success rates. However, initial data from recent randomized, controlled trials suggest that drug-eluting stents are consistently achieving improved patency over PTA alone or over bare metal stents. This review summarizes recent advances in the treatment of infrapopliteal disease.

  3. Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease

    E-Print Network [OSTI]

    von Maltzahn, Geoffrey

    Biomarkers are becoming increasingly important in the clinical management of complex diseases, yet our ability to discover new biomarkers remains limited by our dependence on endogenous molecules. Here we describe the ...

  4. Participatory epidemiology : harnessing the HealthMap platform for community-based disease outbreak monitoring

    E-Print Network [OSTI]

    Freifeld, Clark

    2010-01-01T23:59:59.000Z

    Due to increasing global trade and travel along with a range of environmental factors, emerging infectious diseases such as Severe Acute Respiratory Syndrome (SARS), drug-resistant tuberculosis, and 2009 HiNi continue to ...

  5. S100 Inhibitors: A New Paradigm for Treating Alzheimer’s Disease 

    E-Print Network [OSTI]

    Mathai, David 1991-

    2011-04-27T23:59:59.000Z

    Alzheimer’s disease (AD) is the most common form of dementia, a neurological condition characterized by cognitive impairment and the inability to perform daily tasks. Neuritic protein aggregates in the brain, known as ...

  6. Group Speech Therapy in Individuals With Parkinson Disease: Face-to-Face Versus Telemedicine

    E-Print Network [OSTI]

    Wilson, Kristel Renee

    2008-07-31T23:59:59.000Z

    The purpose of this study was to evaluate the outcomes of group speech therapy for individuals with Parkinson Disease (IWPD) in general and to compare outcomes of group treatment delivered face-to-face (FtF) versus delivery ...

  7. The contribution of disease focused nonprofits to biomedical research and development

    E-Print Network [OSTI]

    Polis Schutz, Jordanna

    2013-01-01T23:59:59.000Z

    Patient-centered, disease-focused nonprofits are playing an increasingly prominent role in accelerating the development of new diagnostics, drugs, and therapies. They are engaging in a variety of complex venture philanthropic ...

  8. www.bluesci.orgIssue 14 Lent 2009 Randomness . Electronic Paper . Huntington's Disease

    E-Print Network [OSTI]

    Cambridge, University of

    www.bluesci.orgIssue 14 Lent 2009 Randomness . Electronic Paper . Huntington's Disease Stories from by Darwinian Chemistry Selection of the fittest molecules Biological Warfare Does biodefence research make us

  9. Is there a relationship between Dichaena rugosa and beech bark disease?

    E-Print Network [OSTI]

    Boyer, Edmond

    Is there a relationship between Dichaena rugosa and beech bark disease? Eberhard O. SPEER of the host tissue (Speer, 1971), so is parasitism on bark. In our case, the infected periderm thickens often

  10. Neurobiology of Disease Neural Basis of Dyslexia: A Comparison between Dyslexic

    E-Print Network [OSTI]

    Neurobiology of Disease Neural Basis of Dyslexia: A Comparison between Dyslexic and Nondyslexic with developmental dyslexia exhibit reduced parietotemporal activation in functional neuroimaging studies words: dyslexia; age-matched; reading ability-matched; parietotemporal region; fMRI; phonological

  11. Poster Presentations 1. BARBARA SHOCK, SOUTHEASTERN COOPERATIVE WILDLIFE DISEASE STUDY, UGA

    E-Print Network [OSTI]

    Arnold, Jonathan

    , IMMUNOLOGY, & PARASITOLOGY, LSU HEALTH SCIENCES CENTER REGULATION OF MITOCHONDRIAL FUNCTION AND VIRULENCE OF BIOINFORMATICS, UGA RECOMBINATION DETECTION PIPELINE FOR LARGE GENE FAMILIES: EVIDENCE OF FREQUENT INTRA GLOBAL DISEASES, UGA RAB11 REGULATES GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)-ANCHOR PROTEIN TRAFFICKING

  12. Pathophysiology of Parkinson's Disease: From Clinical Neurology to Basic Neuroscience and Back

    E-Print Network [OSTI]

    Friedman, Nir

    Pathophysiology of Parkinson's Disease: From Clinical Neurology to Basic Neuroscience and Back of the basic research is oriented toward the study of tremor. In this review, we use the PD tremor as our main

  13. Non-invasive markers of inflammation in cystic fibrosis lung disease 

    E-Print Network [OSTI]

    MacGregor, Gordon

    2010-01-01T23:59:59.000Z

    Cystic fibrosis (CF) lung disease is characterised by early airways infection and inflammation, chronic suppuration, frequent infective exacerbations and an increased influx of acute, and chronic inflammatory cells. The ...

  14. Unraveling the mystery of compost teas used for organic disease and insect pest

    E-Print Network [OSTI]

    Unraveling the mystery of compost teas used for organic disease and insect GilleN #12;What are compost teas? · Watery extracts (teas) made from placing compost in a mesh bag and soaking in water · Plant vs. animal (manure

  15. Nitric oxide and carbon monoxide in cigarette smoke in the development of cardiorespiratory disease in smokers

    E-Print Network [OSTI]

    Borland, Colin David Ross

    1988-10-18T23:59:59.000Z

    Flow Obstruction Smokers may suffer from a spectrum of respiratory disorders ranging from the near universal morning cough to respiratory failure. Much difficulty in understanding the natural history of these diseases results from the different...

  16. MODELING/GIS, RISK ASSESSMENT, ECONOMIC IMPACT Household Model of Chagas Disease Vectors (Hemiptera: Reduviidae)

    E-Print Network [OSTI]

    Vermont, University of

    MODELING/GIS, RISK ASSESSMENT, ECONOMIC IMPACT Household Model of Chagas Disease Vectors (Hemiptera vectors (Hemiptera: Reduviidae) of the causative parasite Trypanosoma cruzi (Kinetoplastida bitten by infected insect vectors. There are 130 species in the subfamily Triatominae (Hemiptera

  17. Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases*

    E-Print Network [OSTI]

    Li, Lian

    to cysteic acid in AD and PD brains. Quantitative Western blot analyses demonstrate that the total level(s) that could potentially be tar- geted by similar therapeutic strategies. Alzheimer disease (AD),1 Parkinson

  18. Root and Root Collar Disease of Eucalyptus grandis Caused by Pythium splendens

    E-Print Network [OSTI]

    Root and Root Collar Disease of Eucalyptus grandis Caused by Pythium splendens 125 C. LINDE, M. J State, P.O. Box 339, Bloemfontein, 9300, South Africa ABSTRACT Linde, c., Wingfield, ~. J., and Kemp, G

  19. Low levels of cardiovascular risk factors and coronary heart disease in a UK Chinese population. 

    E-Print Network [OSTI]

    Harland, J O; Unwin, Nigel; Bhopal, Raj; White, M; Watson, B; Laker, M; Alberti, K G

    1997-01-01T23:59:59.000Z

    OBJECTIVE: To compare the prevalence of cardiovascular risk factors and coronary heart disease in Chinese and Europid adults. DESIGN: Population based, cross sectional survey. SETTING: Newcastle upon Tyne, UK, 1991-93. ...

  20. Prevalences of diabetes and cardiovascular disease risk factors in Hindu Indian subcommunities in Tanzania 

    E-Print Network [OSTI]

    Ramaiya, K L; Swai, A B; McLarty, D G; Bhopal, Raj; Alberti, K G

    1991-01-01T23:59:59.000Z

    OBJECTIVES--To seek differences in the prevalence of diabetes mellitus and other coronary heart disease risk factors, and to identify factors associated with these differences within a Hindu Indian community. DESIGN--Population ...

  1. TREAT TO TARGET: A PROPOSED NEW PARADIGM FOR THE MANAGEMENT OF CROHN'S DISEASE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    TREAT TO TARGET: A PROPOSED NEW PARADIGM FOR THE MANAGEMENT OF CROHN'S DISEASE Short title: Treat Service des Maladie de l'Appareil Digestif et INSERM U991, Centre Hospitalier Universitaire Pontchaillou

  2. Natural Product Biosynthesis: Friend or Foe? From Anti-tumor Agent to Disease Causation 

    E-Print Network [OSTI]

    Foulke-Abel, Jennifer

    2012-02-14T23:59:59.000Z

    biological systems adversely. This work implements recent advances in genomic, proteomic and microbiological technologies to understand further biosynthetic molecules that may influence progression of human disease. Azinomycin A and B are antitumor...

  3. Monitoring Motor Fluctuations in Patients With Parkinson's Disease Using Wearable Sensors

    E-Print Network [OSTI]

    Patel, Shyamal

    This paper presents the results of a pilot study to assess the feasibility of using accelerometer data to estimate the severity of symptoms and motor complications in patients with Parkinson's disease. A support vector ...

  4. Letter Fluency in Motor Neurone Disease: Is there a specific action word deficit? 

    E-Print Network [OSTI]

    Fawns-Ritchie, Chloe

    2013-03-13T23:59:59.000Z

    Recent studies have demonstrated that there is a specific verb, or action word, deficit in patients with a comorbid diagnosis of Motor Neurone Disease (MND) and dementia of the frontotemporal type. However, there has been less research examining...

  5. Effects of Dietary Nucleotides on Growth, Immunology, and Disease Resistance of Juvenile Nile Tilapia (Oreochromis niloticus)

    E-Print Network [OSTI]

    Anguiano, Maritza

    2012-02-14T23:59:59.000Z

    with several fish species have reported that dietary nucleotides can enhance growth performance, immune responses and disease resistance. Therefore, two feeding experiments were conducted to investigate the effects of a purified nucleotide mix on juvenile Nile...

  6. Longitudinal Genome-Wide Association of Cardiovascular Disease Risk Factors in the Bogalusa Heart Study

    E-Print Network [OSTI]

    Peltonen, Leena

    Cardiovascular disease (CVD) is the leading cause of death worldwide. Recent genome-wide association (GWA) studies have pinpointed many loci associated with CVD risk factors in adults. It is unclear, however, if these loci ...

  7. Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease

    E-Print Network [OSTI]

    Sarkar, Sovan

    Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology of lipid-storage disorders is not ...

  8. Telomere Length in Circulating Leukocytes Is Associated with Lung Function and Disease

    E-Print Network [OSTI]

    Nyholt, Dale R.

    Telomere Length in Circulating Leukocytes Is Associated with Lung Function and Disease Eva Albrecht. Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany

  9. UNIVERSITY OF TORONTO ACCIDENT/INCIDENT/OCCUPATIONAL DISEASE REPORT FOR EMPLOYEES

    E-Print Network [OSTI]

    Kronzucker, Herbert J.

    UNIVERSITY OF TORONTO ACCIDENT/INCIDENT/OCCUPATIONAL DISEASE REPORT FOR EMPLOYEES RELEVANT SECTIONS: _______________________________________ NAME OF SUPERVISOR TO WHOM ACCIDENT WAS REPORTED: _________________________________ TELEPHONE: _____________________ IF THERE WAS A DELAY IN REPORTING THIS ACCIDENT, LIST REASON

  10. Transgenic knockout mice with exclusively human sickle hemoglobinand sickle cell disease

    SciTech Connect (OSTI)

    Paszty, C.; Brion, C.; Manci, E.; Witkowska, E.; Stevens, M.; Narla, M.; Rubin, E.

    1997-06-13T23:59:59.000Z

    To create mice expressing exclusively human sicklehemoglobin (HbS), transgenic mice expressing human alpha-, gamma-, andbeta[S]-globin were generated and bred with knockout mice that haddeletions of the murine alpha- and beta-globin genes. These sickle cellmice have the major features (irreversibly sickled red cells, anemia,multiorgan pathology) found in humans with sickle cell disease and, assuch, represent a useful in vivo system to accelerate the development ofimproved therapies for this common genetic disease.

  11. Sapstreak disease of sugar maple: Development over time and space. Forest Service research paper (Final)

    SciTech Connect (OSTI)

    Houston, D.R.

    1994-07-20T23:59:59.000Z

    The sapstreak disease is a potentially serious problem of sugarbushes and forest stands. It is caused by the fungus Ceratocystis virescens, which invades sapwood of roots and bases of stems through wounds created during logging, saphauling, or other activities. The publication describes the results of observations and experiments to learn more about the patterns of disease development and the factors that affect them, within individual trees and within representative forests and sugarbushes.

  12. Seedling disease of sorghum [Sorghum bicolor (L.) Moench]: epidemiology, etiology and resistance

    E-Print Network [OSTI]

    Forbes, Gregory Allan

    1984-01-01T23:59:59.000Z

    SEEDLING DISEASE OF SORGHUM [SORGHUM BICOLOR (L. ) MOENCH]: EPIDEMIOLOGY, ETIOLOGY AND RESISTANCE A Thesis by GREGORY ALLAN FORBES Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 1984 Major Subject: Plant Pathology SEEDLING DISEASE OF SORGHUM [SORGHUM BICOLOR (L. ) MOENCH]: EPIDEMIOLOGY, ETIOLOGY AND RESISTANCE A Thesis GREGORY ALLAN FORBES Approved as to style and content by: 3 Dr. R...

  13. Role of paraoxonase 1 (PON1) in organophosphate metabolism: Implications in neurodegenerative diseases

    SciTech Connect (OSTI)

    Androutsopoulos, Vasilis P. [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece)] [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece); Kanavouras, Konstantinos [Laboratory of Neurological Sciences, University of Crete, Heraklion, Crete (Greece)] [Laboratory of Neurological Sciences, University of Crete, Heraklion, Crete (Greece); Tsatsakis, Aristidis M., E-mail: aris@med.uoc.gr [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece)

    2011-11-15T23:59:59.000Z

    Organophosphate pesticides are a class of compounds that are widely used in agricultural and rural areas. Paraoxonase 1 (PON1) is a phase-I enzyme that is involved in the hydrolysis of organophosphate esters. Environmental poisoning by organophosphate compounds has been the main driving force of previous research on PON1 enzymes. Recent discoveries in animal models have revealed the important role of the enzyme in lipid metabolism. However although PON1 function is well established in experimental models, the contribution of PON1 in neurodegenerative diseases remains unclear. In this minireview we summarize the involvement of PON1 genotypes in the occurrence of Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. A brief overview of latest epidemiological studies, regarding the two most important PON1 coding region polymorphisms PON1-L55M and PON1-Q192R is presented. Positive and negative associations of PON1 with disease occurrence are reported. Notably the MM and RR alleles contribute a risk enhancing effect for the development of some neurodegenerative diseases, which may be explained by the reduced lipoprotein free radical scavenging activity that may give rise to neuronal damage, through distinct mechanism. Conflicting findings that fail to support this postulate may represent the human population ethnic heterogeneity, different sample size and environmental parameters affecting PON1 status. We conclude that further epidemiological studies are required in order to address the exact contribution of PON1 genome in combination with organophosphate exposure in populations with neurodegenerative diseases.

  14. Dental Disease of Rabbits, Guinea Pigs, and Chinchillas Rabbits, guinea pigs, and chinchillas frequently develop serious dental disease that at times

    E-Print Network [OSTI]

    Dental Disease of Rabbits, Guinea Pigs, and Chinchillas Rabbits, guinea pigs, and chinchillas. For example, a rabbit's teeth will grow 5-8 inches (12.7-20.3 cm) per year and a chinchilla's teeth will grow, and chinchillas have teeth (incisors) in the front of their mouths and teeth (premolars and molars, also known

  15. Anal Carcinoma: Impact of TN Category of Disease on Survival, Disease Relapse, and Colostomy Failure in US Gastrointestinal Intergroup RTOG 98-11 Phase 3 Trial

    SciTech Connect (OSTI)

    Gunderson, Leonard L., E-mail: gunderson.leonard@mayo.edu [Mayo Clinic Cancer Center, Scottsdale, Arizona (United States); Moughan, Jennifer [Radiation Therapy Oncology Group, Philadelphia, Pennsylvania (United States); Ajani, Jaffer A. [The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Pedersen, John E. [Cross Cancer Institute, Edmonton, Alberta (Canada); Winter, Kathryn A. [Radiation Therapy Oncology Group, Philadelphia, Pennsylvania (United States); Benson, Al B. [Northwestern University, Chicago, Illinois (United States); Thomas, Charles R. [Knight Cancer Institute/Oregon Health and Science University, Portland, Oregon (United States); Mayer, Robert J. [Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Haddock, Michael G. [Mayo Clinic Cancer Center, Rochester, Minnesota (United States); Rich, Tyvin A. [University of Virginia, Charlottesville, Virginia (United States); Willett, Christopher G. [Duke University, Durham, North Carolina (United States)

    2013-11-15T23:59:59.000Z

    Purpose: The long-term update of US GI Intergroup RTOG 98-11 anal cancer trial found that concurrent chemoradiation (CCRT) with fluorouracil (5-FU) plus mitomycin had a significant impact on disease-free survival (DFS) and overall survival (OS) compared with induction plus concurrent 5-FU plus cisplatin. The intent of the current analysis was to determine the impact of tumor node (TN) category of disease on survival (DFS and OS), colostomy failure (CF), and relapse (local-regional failure [LRF] and distant metastases [DM]) in this patient group. Methods and Materials: DFS and OS were estimated univariately by using the Kaplan-Meier method, and 6 TN categories were compared by the log–rank test (T2N0, T3N0, T4N0, T2N1-3, T3N1-3, and T4N1-3). Time to relapse and colostomy were estimated by the cumulative incidence method, and TN categories were compared using Gray's test. Results: Of 682 patients, 620 were analyzable for outcomes by TN category. All endpoints showed statistically significant differences among the TN categories of disease (OS, P<.0001; DFS, P<.0001; LRF, P<.0001; DM, P=.0011; CF, P=.01). Patients with the poorest OS, DFS, and LRF outcomes were those with T3-4N-positive (+) disease. CF was lowest for T2N0 and T2N+ (11%, 11%, respectively) and worst for the T4N0, T3N+, and T4N+ categories (26%, 27%, 24%, respectively). Conclusions: TN category of disease has a statistically significant impact on OS, DFS, LRF, DM, and CF in patients treated with CCRT and provides excellent prognostic information for outcomes in patients with anal carcinoma. Significant challenges remain for patients with T4N0 and T3-4N+ categories of disease with regard to survival, relapse, and CF and lesser challenges for T2-3N0/T2N+ categories.

  16. Multiplexed Molecular Assays for Rapid Rule-Out of Foot-and-Mouth Disease

    SciTech Connect (OSTI)

    Lenhoff, R; Naraghi-Arani, P; Thissen, J; Olivas, J; Carillo, C; Chinn, C; Rasmussen, M; Messenger, S; Suer, L; Smith, S M; Tammero, L; Vitalis, E; Slezak, T R; Hullinger, P J; Hindson, B J; Hietala, S; Crossley, B; Mcbride, M

    2007-06-26T23:59:59.000Z

    A nucleic acid-based multiplexed assay was developed that combines detection of foot-and-mouth disease virus (FMDV) with rule-out assays for two other foreign animal diseases and four domestic animal diseases that cause vesicular or ulcerative lesions indistinguishable from FMDV infection in cattle, sheep and swine. The FMDV 'look-alike' diagnostic assay panel contains five PCR and twelve reverse transcriptase PCR (RT-PCR) signatures for a total of seventeen simultaneous PCR amplifications for seven diseases plus incorporating four internal assay controls. It was developed and optimized to amplify both DNA and RNA viruses simultaneously in a single tube and employs Luminex{trademark} liquid array technology. Assay development including selection of appropriate controls, a comparison of signature performance in single and multiplex testing against target nucleic acids, as well of limits of detection for each of the individual signatures is presented. While this assay is a prototype and by no means a comprehensive test for FMDV 'look-alike' viruses, an assay of this type is envisioned to have benefit to a laboratory network in routine surveillance and possibly for post-outbreak proof of freedom from foot-and-mouth disease.

  17. Diagnostic evaluation of a multiplexed RT-PCR microsphere array assay for the detection of foot-and-mouth disease virus and look-alike disease viruses

    SciTech Connect (OSTI)

    Hindson, B J; Reid, S M; Baker, B R; Ebert, K; Ferris, N P; Bentley Tammero, L F; Lenhoff, R J; Naraghi-Arani, P; Vitalis, E A; Slezak, T R; Hullinger, P J; King, D P

    2007-07-26T23:59:59.000Z

    A high-throughput multiplexed assay was developed for the differential laboratory diagnosis of foot-and-mouth disease virus (FMDV) from viruses which cause clinically similar diseases of livestock. This assay simultaneously screens for five RNA and two DNA viruses using multiplexed reverse transcription PCR (mRT-PCR) amplification coupled with a microsphere hybridization array and flow-cytometric detection. Two of the seventeen primer-probe sets included in this multiplex assay were adopted from previously characterized real-time RT-PCR (rRT-PCR) assays for FMDV. The diagnostic accuracy of the mRT-PCR was evaluated using 287 field samples, including 248 (true positive n= 213, true negative n=34) from suspect cases of foot-and-mouth disease collected from 65 countries between 1965 and 2006 and 39 true negative samples collected from healthy animals. The mRT-PCR assay results were compared with two singleplex rRT-PCR assays, using virus isolation with antigen-ELISA as the reference method. The diagnostic sensitivity of the mRT-PCR assay for FMDV was 93.9% [95% C.I. 89.8-96.4%], compared to 98.1% [95% C.I. 95.3-99.3%] for the two singleplex rRT-PCR assays used in combination. In addition, the assay could reliably differentiate between FMDV and other vesicular viruses such as swine vesicular disease virus and vesicular exanthema of swine virus. Interestingly, the mRT-PCR detected parapoxvirus (n=2) and bovine viral diarrhea virus (n=2) in clinical samples, demonstrating the screening potential of this mRT-PCR assay to identify viruses in FMDV-negative material not previously recognized using focused single-target rRT-PCR assays.

  18. Introduction to Focus Issue: Rhythms and Dynamic Transitions in Neurological Disease: Modeling, Computation, and Experiment

    SciTech Connect (OSTI)

    Kaper, Tasso J., E-mail: tasso@bu.edu; Kramer, Mark A., E-mail: mak@bu.edu [Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215 (United States); Rotstein, Horacio G., E-mail: horacio@njit.edu [Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, New Jersey 07102 (United States)

    2013-12-15T23:59:59.000Z

    Rhythmic neuronal oscillations across a broad range of frequencies, as well as spatiotemporal phenomena, such as waves and bumps, have been observed in various areas of the brain and proposed as critical to brain function. While there is a long and distinguished history of studying rhythms in nerve cells and neuronal networks in healthy organisms, the association and analysis of rhythms to diseases are more recent developments. Indeed, it is now thought that certain aspects of diseases of the nervous system, such as epilepsy, schizophrenia, Parkinson's, and sleep disorders, are associated with transitions or disruptions of neurological rhythms. This focus issue brings together articles presenting modeling, computational, analytical, and experimental perspectives about rhythms and dynamic transitions between them that are associated to various diseases.

  19. Escaping the poverty trap: modeling the interplay between economic growth and the ecology of infectious disease

    E-Print Network [OSTI]

    Goerg, Georg M; Hébert-Dufresne, Laurent; Althouse, Benjamin M

    2013-01-01T23:59:59.000Z

    The dynamics of economies and infectious disease are inexorably linked: economic well-being influences health (sanitation, nutrition, treatment capacity, etc.) and health influences economic well-being (labor productivity lost to sickness and disease). Often societies are locked into ``poverty traps'' of poor health and poor economy. Here, using a simplified coupled disease-economic model with endogenous capital growth we demonstrate the formation of poverty traps, as well as ways to escape them. We suggest two possible mechanisms of escape both motivated by empirical data: one, through an influx of capital (development aid), and another through changing the percentage of GDP spent on healthcare. We find that a large influx of capital is successful in escaping the poverty trap, but increasing health spending alone is not. Our results demonstrate that escape from a poverty trap may be possible, and carry important policy implications in the world-wide distribution of aid and within-country healthcare spending.

  20. Modeling Economic Resilience and Animal Disease Outbreaks in the Texas High Plains 

    E-Print Network [OSTI]

    Lin, Hen-I

    2012-02-14T23:59:59.000Z

    at the local level to prevent the outbreak from happening has grown to be a critical issue in the area of animal disease control, particularly within the context of modern agricultural industry. Because FMD is the most contagious animal disease of hoofed... to slaughter on infected premises, and the intensity of contagious and non-contagious premises. They found that the average time from the first lesion to slaughter control and the intensity of culling on non-contagious premises has a 15 significant...

  1. Development of knowledge Base Expert System for Natural treatment of Diabetes disease

    E-Print Network [OSTI]

    Jha, Sanjeev Kumar

    2012-01-01T23:59:59.000Z

    The development of expert system for treatment of Diabetes disease by using natural methods is new information technology derived from Artificial Intelligent research using ESTA (Expert System Text Animation) System. The proposed expert system contains knowledge about various methods of natural treatment methods (Massage, Herbal/Proper Nutrition, Acupuncture, Gems) for Diabetes diseases of Human Beings. The system is developed in the ESTA (Expert System shell for Text Animation) which is Visual Prolog 7.3 Application. The knowledge for the said system will be acquired from domain experts, texts and other related sources.

  2. ArabidopsisWRKY70 is required for full RPP4-mediated disease resistance and basal defense against Hyaloperonospora parasitica

    E-Print Network [OSTI]

    Knoth, Colleen; Ringler, Jon; Dangl, Jeffery L; Eulgem, Thomas

    2007-01-01T23:59:59.000Z

    Nature 415:977-980. Bartsch, M. , Gobbato, E. , Bednarek,for disease resistance (Bartsch et al. 2006; Ramonell et al.

  3. Particulate Air Pollution, Ambulatory Heart Rate Variability, and Cardiac Arrhythmia in Retirement Community Residents with Coronary Artery Disease

    E-Print Network [OSTI]

    Bartell, Scott M.; Longhurst, John; Tjoa, Thomas; Sioutas, Constantinos; Delfino, Ralph J.

    2013-01-01T23:59:59.000Z

    in association with air pollution and air temperature amongvariability with traffic and air pollution in patients withParticulate matter air pollution and cardiovascular disease:

  4. Particulate air pollution, ambulatory heart rate variability, and cardiac arrhythmia in retirement community residents with coronary artery disease.

    E-Print Network [OSTI]

    Bartell, Scott M; Longhurst, John; Tjoa, Thomas; Sioutas, Constantinos; Delfino, Ralph J

    2013-01-01T23:59:59.000Z

    in association with air pollution and air temperature amongvariability with traffic and air pollution in patients withParticulate matter air pollution and cardiovascular disease:

  5. Protective Effect of Nrf2 and Catalase in Maternal Diabetes-Induced Perinatal Hypertension and Kidney Disease

    E-Print Network [OSTI]

    Vaziri, Nosratola D.

    2012-01-01T23:59:59.000Z

    Diabetes-Induced Perinatal Hypertension and Kidney Diseaseof Nephrology and Hypertension, Deparment of Medicine,of renal disease and hypertension. ACKNOWLEDGMENTS No

  6. Factors determining the progression of nonalcoholic fatty liver disease; the role of abnormal fatty acid and glucocorticoid metabolism 

    E-Print Network [OSTI]

    MacFarlane, David Peter

    2011-11-25T23:59:59.000Z

    Obesity and insulin resistance are associated with a constellation of features including hypertension, dyslipidaemia, type 2 diabetes, and premature cardiovascular disease, collectively termed the metabolic syndrome. ...

  7. Applications of Data-driven Modeling to Infectious Diseases in Africa: Anthrax in Wildlife and HIV in Humans

    E-Print Network [OSTI]

    Bellan, Steven Edward

    2012-01-01T23:59:59.000Z

    Estimating wind turbine-caused bird mortality. Journal ofestimation of wildlife mortality due to wind farms (Flint etsurveillance of mortality due to disease, wind farms,

  8. Coral Health and Disease: A Comparison of Cook's and Opunohu Bays in Mo'orea,French Polynesia

    E-Print Network [OSTI]

    Shea, Alessandra

    2011-01-01T23:59:59.000Z

    lagoon  on  New  Caledonia.   Coral  Reef  Initiatives  for Predictive  Modeling  of  Coral  Disease  Distribution natural  disturbances  on  coral  assemblages  in  French 

  9. Could mitochondrial efficiency explain the susceptibility to adiposity, metabolic syndrome, diabetes and cardiovascular diseases in South Asian populations? 

    E-Print Network [OSTI]

    Bhopal, Raj; Rafnsson, Snorri B

    2009-01-01T23:59:59.000Z

    Background South Asians are susceptible to cardiovascular disease (CVD), especially after migration to affluent countries. Contributing factors include high prevalence of diabetes, and possibly insulin resistance. Excess ...

  10. Life-cycle Environmental Inventory of Passenger Transportation in the United States

    E-Print Network [OSTI]

    Chester, Mikhail V

    2008-01-01T23:59:59.000Z

    Methyl tert?Butyl Ether (MTBE); http://www.atsdr.cdc.gov/Methyl Tertiary Butyl  Ether  (MTBE),  which  was  easily accounting was not performed on MTBE and the result  of 

  11. Fiscal Year Justification of

    E-Print Network [OSTI]

    effects due to toluene diisocyanate (TDI), a substance known to be the largest contributor and document the impact of ATSDR's efforts on the health of people exposed to toxic substances. This FY 2012

  12. Dynamical changes in neurological diseases and anesthesia Michelle M McCarthy1

    E-Print Network [OSTI]

    Kopell, Nancy

    Dynamical changes in neurological diseases and anesthesia Michelle M McCarthy1 , ShiNung Ching1 within the networks known to be relevant to each disorder. We also discuss anesthesia, since Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit St., GRJ

  13. Will our final years be golden? Mortality by Alzheimer's disease in the United States

    E-Print Network [OSTI]

    Davis, Mary Ann

    2007-09-17T23:59:59.000Z

    Page A.1 Magnetic Resonance Imaging (MRI) of Brain Atrophy in Alzheimer's Disease........................................................... 125 A.2 Population Pyramid Summary for the United States ............. 126 A.3 Percentage..., Decedents Over Age 60, United States 1998-2002.................................................................... 157 G.2 Frequency of Mortality by Ethnicity in Decedents Over Age 60 in the United States, 1998...

  14. DISASTER MEDICINE/ORIGINAL RESEARCH Burden of Disease and Health Status Among Hurricane Katrina

    E-Print Network [OSTI]

    Scharfstein, Daniel

    DISASTER MEDICINE/ORIGINAL RESEARCH Burden of Disease and Health Status Among Hurricane Katrina: Anecdotal evidence suggests that the population displaced to shelters from Hurricane Katrina had in Louisiana 2 weeks after landfall of Hurricane Katrina. In stage 1, shelters with a population of more than

  15. Respiratory disease and particulate air pollution in Santiago Chile: Contribution of erosion particles from fine sediments

    E-Print Network [OSTI]

    Commentary Respiratory disease and particulate air pollution in Santiago Chile: Contribution pollution Santiago Erosion Sedimentation a b s t r a c t Air pollution in Santiago is a serious problem for a couple of days, followed by extreme levels of air pollution. Current regulations focus mostly on PM10

  16. Healthy Housing Reference Manual Now Available The Centers for Disease Control and Prevention

    E-Print Network [OSTI]

    Healthy Housing Reference Manual Now Available The Centers for Disease Control and Prevention (CDC)/U.S. Department of Housing and Urban Development (HUD) Healthy Housing Reference Manual is a revised and updated edition of the 1976 CDC Basic Healthy Housing Inspection manual. The Healthy Housing Reference Manual

  17. Questions and Answers About LeukemiaCENTERS FOR DISEASE CONTROL AND PREVENTION

    E-Print Network [OSTI]

    the disease develops (acute vs. chronic leukemia) and by the type of blood cell involved (lymphocytic and myeloid leukemia being the most common). In acute leukemia, bone marrow cells are immature and are unable slowly. The most common types of leukemia are acute lymphocytic leukemia, acute myeloid leukemia, chronic

  18. 712 Plant Disease / Vol. 96 No. 5 Culture-Based Assessment of Microbial Communities in Soil

    E-Print Network [OSTI]

    Douches, David S.

    of CS and SS samples showed no clear trends or differences in popula- tions of total fungi, total, the disease affects tuber quality by resulting in superficial, raised, or pitted lesions on the periderm (19 industry (NASS, 2010) due to lack of effective control methods (9). Management of PCS is difficult. Scab

  19. Plant Disease / October 2001 1113 Effect of Host Plant Resistance and Reduced Rates and Frequencies

    E-Print Network [OSTI]

    Douches, David S.

    Plant Disease / October 2001 1113 Effect of Host Plant Resistance and Reduced Rates and Frequencies. These include the use of fungicides with less active ingredient, re- duced application rates, longer application. The frequent fungicide spray intervals and rates currently used by growers to control late blight are expensive

  20. Ontology based Holonic Diagnostic System (OHDS) for the Research and Control of Unknown Diseases

    E-Print Network [OSTI]

    Ulieru, Mihaela

    Ontology based Holonic Diagnostic System (OHDS) for the Research and Control of Unknown Diseases Alberta, Canada Email: ulieru@ucalgary.ca Abstract - This paper presents an Ontology-based Holonic Diagnostic System (OHDS) that combines the advantages of the holonic paradigm with multi-agent system

  1. Chronic Kidney Disease and Hypertension: The Paradox of Treating Patients with Spironolactone

    E-Print Network [OSTI]

    Pillow, Jonathan

    Chronic Kidney Disease and Hypertension: The Paradox of Treating Patients with Spironolactone Amber the correlation between CKD and hypertension 2. Describe the role of aldosterone in the renin-angiotensin-aldosterone system (RAAS) and in resistant hypertension 3. Explain the mechanism of aldosterone antagonists 4

  2. New Insights Into the Role of Equine Infectious Anemia Virus S2 Protein in Disease Expression

    E-Print Network [OSTI]

    Covaleda Salas, Lina M.

    2011-08-08T23:59:59.000Z

    macrophages. Specifically, S2 enhances the expression of IL-1 alpha, IL-1 beta IL-8, MCP-2, MIP-1 beta, IP-10 and a newly discovered cytokine, IL-34. Involvement of S2 in cytokine and chemokine dysregulation may contribute to disease development by optimizing...

  3. Study of Genomic Copy Number Variation in Equine Health and Disease

    E-Print Network [OSTI]

    Ghosh, Sharmila

    2014-07-30T23:59:59.000Z

    This is a study of copy number variations (CNVs) in the horse genome to gain knowledge about the role of CNVs in equine biology, and their contribution to complex diseases and disorders. We constructed a 400K whole-genome tiling array and applied...

  4. ARTICLE IN PRESS 3 Mapping cortical change in Alzheimer's disease, brain development,

    E-Print Network [OSTI]

    Thompson, Paul

    's disease, schizo- 19 phrenia, normal aging, and abnormal brain development based on 20 imaging data, not seen in individual brain scans, often emerge when 45population-based brain data are averaged School of Medicine, Los Angeles, CA 90095-1769, United States 9 b Child Psychiatry Branch, NIMH, Bethesda

  5. Plant Disease / March 1999 279 The Relationship of Gin Date to Aflatoxin Contamination of Cottonseed

    E-Print Network [OSTI]

    Cotty, Peter J.

    Plant Disease / March 1999 279 The Relationship of Gin Date to Aflatoxin Contamination crops and is frequently, as with cottonseed, the primary cause of aflatoxin contamination (13). When. Irrigation can influence aflatoxin contamination, par- ticularly if continued into the harvest sea- son (19

  6. Veterans' Health Activities Since its inception, the Centers for Disease Control and Prevention (CDC) has been

    E-Print Network [OSTI]

    with that of 8,989 Vietnam-era veterans who served in Korea, Germany, or the United States. Over the entire follow-up period, the total death rate for Vietnam veterans was 17% higher than for other veterans of the study group (mean = 53 years) and longer follow-up period (average 30 years), death rates from disease

  7. Disease Risk in Temperate Amphibian Populations Is Higher at Closed-Canopy Sites

    E-Print Network [OSTI]

    Zamudio, Kelly R.

    University. The funders had no role in study design, data collection and analysis, decision to publishDisease Risk in Temperate Amphibian Populations Is Higher at Closed-Canopy Sites C. Guilherme is critical for predicting Bd spread and developing appropriate management tools for wild populations

  8. Evolutionary Determinants of Genetic Variation in Susceptibility to Infectious Diseases in Humans

    E-Print Network [OSTI]

    Antonovics, Janis

    . The funders had no role in study design, data collection and analysis, decision to publish, or preparation with the different types of resistance mechanisms. An appreciation of these observed patterns will be a valuable tool from an infection; this increased risk associated with infectious disease was highe

  9. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK

    E-Print Network [OSTI]

    Sulzer, David

    Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and m protein accumulation as well as astrocyte function. In this study, we found that GFAP accumulation induces is negatively regulated by mammalian target of rapamycin (mTOR). The activation of p38 MAPK by GFAP accumulation

  10. CRASSOSTREA ARIAKENSIS IN CHESAPEAKE BAY: GROWTH, DISEASE AND MORTALITY IN SHALLOW SUBTIDAL ENVIRONMENTS

    E-Print Network [OSTI]

    Paynter, Kennedy T.

    -salinity sites were located in the Choptank and Patuxent Rivers. The highest salinity site was located Bay. In Maryland, the lowest salinity site was located in the Severn River and two low to mid in the York River in Virginia. Growth, disease acquisition, and mortality were measured in the deployed

  11. Characteristics of Marine Aggregates in Shallow-water Ecosystems: Implications for Disease Ecology

    E-Print Network [OSTI]

    Allam, Bassem

    hydrophila, Pseudomonas aeruginosa, Escherichia coli, and Mycobacteria sp. These results have importantCharacteristics of Marine Aggregates in Shallow-water Ecosystems: Implications for Disease Ecology Smolowitz,4 Joseph Vallino,4 and Bassem Allam2 1 Department of Marine Sciences, University of Connecticut

  12. DISEASE-SPECIFIC BRAIN ATLASES Paul M. Thompson, 1,2

    E-Print Network [OSTI]

    Thompson, Paul

    1 DISEASE-SPECIFIC BRAIN ATLASES 1 Paul M. Thompson, 1,2 Michael S. Mega, and 1 Arthur W. Toga 1. Mazziotta and Arthur W. Toga, Editors Academic Press Please address correspondence to: Dr. Paul Thompson (Rm-mail: thompson@loni.ucla.edu Acknowledgments: This work was supported by research grants from the National Center

  13. Vavien: An Algorithm for Prioritizing Candidate Disease Genes Based on Topological Similarity

    E-Print Network [OSTI]

    Koyuturk, Mehmet

    experimental studies using an integrated human PPI network and the Online Mendelian Inheritance in Man (OMIM Characterization of disease-associated variants in human genome is an important step toward enhancing our University, Cleveland, Ohio. 3 Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio. JOURNAL

  14. CS233917-AF National Center for Chronic Disease Prevention and Health Promotion

    E-Print Network [OSTI]

    CS233917-AF National Center for Chronic Disease Prevention and Health Promotion Division, Physical Activity, and Obesity Profile Obesity has important consequences on our nation's health by unhealthy options when it comes to diet and physical activity.We need public health approaches that make

  15. Differential C3NET reveals disease networks of direct physical interactions

    E-Print Network [OSTI]

    Altay, Gokmen; Asim, Mohammad; Markowetz, Florian; Neal, David E

    2011-07-21T23:59:59.000Z

    . Mol Syst Biol 2007, 3. 15. Barabàsi A, Gulbahce N, Loscalzo J: Network medicine: a network-based approach to human disease. Nat Rev Genet 2011, 12:56-68. 16. Fuller TF, Ghazalpour A, Aten JE, Drake TA, Lusis AJ, Horvath S: Weighted gene coexpression...

  16. Higher coronary heart disease and heart attack morbidity in Appalachian coal mining regions

    SciTech Connect (OSTI)

    Hendryx, M.; Zullig, K.J. [West Virginia University, Morgantown, WV (United States). Dept. of Community Medicine

    2009-11-15T23:59:59.000Z

    This study analyzes the U.S. 2006 Behavioral Risk Factor Surveillance System survey data (N = 235,783) to test whether self-reported cardiovascular disease rates are higher in Appalachian coal mining counties compared to other counties after control for other risks. Dependent variables include self-reported measures of ever (1) being diagnosed with cardiovascular disease (CVD) or with a specific form of CVD including (2) stroke, (3) heart attack, or (4) angina or coronary heart disease (CHD). Independent variables included coal mining, smoking, BMI, drinking, physician supply, diabetes co-morbidity, age, race/ethnicity, education, income, and others. SUDAAN Multilog models were estimated, and odds ratios tested for coal mining effects. After control for covariates, people in Appalachian coal mining areas reported significantly higher risk of CVD (OR = 1.22, 95% CI = 1.14-1.30), angina or CHO (OR = 1.29, 95% C1 = 1.19-1.39) and heart attack (OR = 1.19, 95% C1 = 1.10-1.30). Effects were present for both men and women. Cardiovascular diseases have been linked to both air and water contamination in ways consistent with toxicants found in coal and coal processing. Future research is indicated to assess air and water quality in coal mining communities in Appalachia, with corresponding environmental programs and standards established as indicated.

  17. Mycosphaerella species associated with leaf disease of Eucalyptus globulus in Ethiopia

    E-Print Network [OSTI]

    Mycosphaerella species associated with leaf disease of Eucalyptus globulus in Ethiopia By Alemu, Forestry Research Sector, Addis Ababa, Ethiopia; 2 Department of Plant Pathology and Microbiology, Tree spp. are among the most widely planted exotic trees in Ethiopia. Several damaging leaf pathogens

  18. ABSTRACT Genomics and bioinformatics have the vast potential to identify genes that cause disease by investigating

    E-Print Network [OSTI]

    Hammock, Bruce D.

    ABSTRACT Genomics and bioinformatics have the vast potential to identify genes that cause disease by investigating whole-genome databases. Comparison of an individual's geno- type with a genomic database these metabolic profiles with genomic, expression, and proteomic databases. Application of the knowledge of indi

  19. Nonblack patients with sickle cell disease have African. beta. sup s gene cluster haplotypes

    SciTech Connect (OSTI)

    Rogers, Z.R.; Powars, D.R.; Williams, W.D. (Univ. of Southern California School of Medicine, Los Angeles (USA)); Kinney, T.R. (Duke Univ., Durham, NC (USA)); Schroeder, W.A. (California Institute of Technology, Pasadena (USA))

    1989-05-26T23:59:59.000Z

    Of 18 nonblack patients with sickle cell disease, 14 had sickle cell anemia, 2 had hemoglobin SC disease, and 2 had hemoglobin S-{beta}{sup o}-thalassemia. The {beta}{sup s} gene cluster haplotypes that were determined in 7 patients were of African origin and were identified as Central African Republic, Central African Republic minor II, Benin, and Senegal. The haplotype Central African Republic minor II was present on the {beta}{sup o}-thalassemia chromosome in 2 patients. None of 10 patients whose {alpha}-gene status was determined had {alpha}-thalassemia-2. These data strongly support the concept that the {beta}{sup s} gene on chromosome 11 of these individuals is of African origin and that the {alpha}-gene locus on chromosome 16 is of white or native American origin. The clinical severity of the disease in these nonblack patients is appropriate to their haplotype without {alpha}-thalassemia-2 and is comparable with that of black patients. All persons with congenital hemolytic anemia should be examined for the presence of sickle cell disease regardless of physical appearance or ethnic background.

  20. Developing microbeplant interactions for applications in plant-growth promotion and disease control,

    E-Print Network [OSTI]

    Chen, Wilfred

    and disease control, production of useful compounds, remediation and carbon sequestration Cindy H. Wu,1-growth promotion, biocontrol, bioactive compound and biomaterial production, remediation and carbon sequestration economical (Anderson et al., 1993). Carbon sequestration through plant­rhizosphere processes is a potentially