National Library of Energy BETA

Sample records for disease orthopedic maternity

  1. Nanostructured apatites as orthopedic biomaterials

    E-Print Network [OSTI]

    Ahn, Edward Sun, 1972-

    2001-01-01

    Historically, using suitable mechanical replacements for bone has been a priority in designing permanent, load-bearing orthopedic implants. As a result, the biomaterials used in these implants have been largely limited to ...

  2. Development of a novel orthopedic microfastener 

    E-Print Network [OSTI]

    Agnihotri, Mukul Mukund

    2007-04-25

    Over the last decade, biodegradable screws and plates have received wide acceptance over metallic fasteners for orthopedic fracture fixation. A biodegradable fastener would gradually "disappear" during healing of a fractured bone or tissues...

  3. A Novel Wireless Health Orthopedic System Integrating Motion and Acoustic Emission Monitoring

    E-Print Network [OSTI]

    Paul, Manda

    2013-01-01

    id/ds-260/lang/en›. [10] Wireless Ethernet Bridge (WET54G).Los Angeles A Novel Wireless Health Orthopedic SystemOF THE THESIS A Novel Wireless Health Orthopedic System

  4. In-vivo orthopedic implant diagnostic device for sensing load, wear, and infection

    DOE Patents [OSTI]

    Evans, III, Boyd McCutchen; Thundat, Thomas G.; Komistek, Richard D.; Dennis, Douglas A.; Mahfouz, Mohamed

    2006-08-29

    A device for providing in vivo diagnostics of loads, wear, and infection in orthopedic implants having at least one load sensor associated with the implant, at least one temperature sensor associated with the implant, at least one vibration sensor associated with the implant, and at least one signal processing device operatively coupled with the sensors. The signal processing device is operable to receive the output signal from the sensors and transmit a signal corresponding with the output signal.

  5. Introduction Evolution of maternal effects: past and present

    E-Print Network [OSTI]

    Badyaev, Alex

    Introduction Evolution of maternal effects: past and present 1. A BRIEF HISTORY OF `MATERNAL true for the subfield of maternal effects evolution. The study of maternal effects has a long history. The first two papers reported in the ISI database dealing with the evolutionary significance of maternal

  6. Alternative accounting in maternal and infant global health

    E-Print Network [OSTI]

    Adams, V; Craig, SR; Samen, A

    2015-01-01

    542– 549. Lambert, H. (2006). Accounting for EBM: Notions ofloi/rgph20 Alternative accounting in maternal and infantSamen (2015): Alternative accounting in maternal and infant

  7. Investigation of a HA/PDLGA/Carbon Foam Material System for Orthopedic Fixation Plates Based on Time-Dependent Properties 

    E-Print Network [OSTI]

    Rodriguez, Douglas E.

    2010-01-14

    Page 1.1 Mechanical properties of bone and typical metallic and ceramic biomaterials [12] (as detailed by Ramakrishna et al. [13]) ............................. 4 1.1 Mechanical properties of typical bioresorbable polymers [14... The use of bioresorbable polymers, materials that degrade within the body and are resorbed through the body’s metabolic cycle, has been proposed for orthopedic applications since the advent of these polymers as a biomaterial[1]. Since the introduction...

  8. Maternal and Infant Iron Status and First Year Illness

    E-Print Network [OSTI]

    Douglas, Sarah E.

    2011-04-20

    Abstract The primary research aims were to understand the relationship between maternal postpartum body iron and birth and 4-month infant body iron and to determine if maternal or newborn iron status was a predictor of first year illness. Subjects...

  9. Maternal Anesthesia via Isoflurane or Ether Differentially

    E-Print Network [OSTI]

    Maternal Anesthesia via Isoflurane or Ether Differentially Affects Pre-and Postnatal Behavior Program in Occupational Therapy Washington University School of Medicine St. Louis, MO 63108 Jeffrey R: Our understanding of prenatal behavior has been significantly advanced by techniques for direct

  10. Sex-biased maternal effects reduce ectoparasite-induced mortality

    E-Print Network [OSTI]

    Badyaev, Alex

    logistic growth parasites sexual dimorphism Developmental periods, such as incubation and nestling stagesSex-biased maternal effects reduce ectoparasite-induced mortality in a passerine bird Alexander V of developmental periods is ex- pected to be slow. In birds, maternal effects on egg-laying order and offspring

  11. Maternal Responsiveness to Infant Norway Rat (Rattus norvegicus) Ultrasonic Vocalizations During the Maternal Behavior Cycle and After

    E-Print Network [OSTI]

    Maternal Responsiveness to Infant Norway Rat (Rattus norvegicus) Ultrasonic Vocalizations During environment, Norway rat (Rattus norvegicus) pups emit ultrasonic vocalizations that can elicit maternal search is particularly important in altricial species such as the Norway rat in which infants rely on the mother

  12. Comparison of fetal and maternal susceptibility to decompression sickness 

    E-Print Network [OSTI]

    Brown, Steven Dunning

    1979-01-01

    COMPARISON OF FETAL AND MATERNAL SUSCEPTIBILITV TO DECOMPRESSION SICKNESS A TheSis by STEVEN DUNNING BROWN Submitted to the Graduate College of Texas ARM University in partial fulfillment of the requirement for the degree of MASTER... OF SCIENCE December 1979 Major Subject: Biology COMPARISON OF FETAL AND MATERNAL SUSCEPTIBILITY TO DECOMPRESSION SICKNESS A Thesis by STEVEN DUNNING BROWN Approved as to style and content by: irman of Committee Member Member Mem er ead of Depar...

  13. Programming of cardiovascular disease across the life-course

    E-Print Network [OSTI]

    Blackmore, Heather L.; Ozanne, Susan E.

    2014-12-12

    ]. This increase in lifespan brings about a rise in age-associated conditions such as type 2 diabetes, cancer and cardiovascular disease (CVD). As CVD has a long pre-clinical phase resulting in diagnosis in old age, the identification of biomarkers that precede... F, Carter F, Walsh SW, Kenny DA, Smith GW, Ireland JL, et al. Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring. Biol Reprod. 2013;88:92. [33] Gilbert JS, Lang AL, Grant AR, Nijland MJ. Maternal nutrient...

  14. Brain oxytocin correlates with maternal aggression: Link to anxiety 

    E-Print Network [OSTI]

    Meddle, S. L.; Beiderbeck, D. I.; Douglas, A. J.; Neumann, I. D.; Bosch, O. J.

    2005-01-01

    and CeA. Using retrodialysis, blockade of endogenous oxytocin action by infusion of an oxytocin receptor antagonist (des-Gly-NH2,d(CH2)5[Tyr(Me)2,Thr4]OVT) into the PVN or CeA reduced maternal aggression of HAB dams, whereas infusion of synthetic oxytocin...

  15. A Maternal Ahr Null Genotype Sensitizes Embryos to Chemical Teratogenesis*

    E-Print Network [OSTI]

    Bradfield, Christopher A.

    the toxicology and teratology of 2,3,7,8-tetrachlo- rodibenzo-p-dioxin (dioxin). In an effort to understand the role of the maternal compartment in dioxin teratol- ogy, we designed a breeding strategy that allowed this strategy, we demonstrate that embryos from the Ahr / dams are 5-fold more sensitive to dioxin-induced cleft

  16. Sorghum Diseases

    E-Print Network [OSTI]

    Amador, Jose; Berry, Robert W.; Frederiksen, Richard A.; Horne, C. Wendell; Thames, Walter H.; Toler, Robert W.

    1969-01-01

    Foreign animal disease can cause serious damage to the United States (US) agricultural sector and foot-and-mouth disease (FMD), in particular, poses a serious threat. FMD causes death and reduced fecundity in infected ...

  17. Information Regarding MENINGOCOCCAL DISEASE

    E-Print Network [OSTI]

    . Meningococcal disease is a serious disease, caused by bacteria. Meningococcal disease is a contagious

  18. Interactive effects of maternal and environmental exposure to coal combustion wastes decrease survival of larval southern toads (Bufo terrestris)

    E-Print Network [OSTI]

    Georgia, University of

    Interactive effects of maternal and environmental exposure to coal combustion wastes decrease Accepted 29 January 2012 Keywords: Amphibian Coal combustion wastes Contaminants Trace elements Selenium terrestris). Previous maternal exposure to coal combustion wastes (CCW) reduced larval survival

  19. Infant Formula with Docosahexaenoic Acid, Maternal Smoking, and Body Mass Index of Children To Six Years of Age

    E-Print Network [OSTI]

    Currie, Lindsey Marie

    2012-05-31

    Research findings have suggested no differences in growth among term infants fed DHA supplemented formulas. Studies have found maternal smoking decreases length and increases weight of children. No studies have analyzed maternal smoking and DHA...

  20. Does breastfeeding offer protection against maternal depressive symptomatology?: A prospective study from pregnancy to 2 years after birth

    E-Print Network [OSTI]

    Hahn-Holbrook, J; Haselton, MG; Dunkel Schetter, C; Glynn, LM

    2013-01-01

    Does breastfeeding offer protection against maternalARTICLE Does breastfeeding offer protection against maternalthat breastfeeding could offer such protective benefits.

  1. SU-E-I-63: Quantitative Evaluation of the Effects of Orthopedic Metal Artifact Reduction (OMAR) Software On CT Images for Radiotherapy Simulation

    SciTech Connect (OSTI)

    Jani, S [Sharp Memorial Hospital, San Diego, CA (United States)

    2014-06-01

    Purpose: CT simulation for patients with metal implants can often be challenging due to artifacts that obscure tumor/target delineation and normal organ definition. Our objective was to evaluate the effectiveness of Orthopedic Metal Artifact Reduction (OMAR), a commercially available software, in reducing metal-induced artifacts and its effect on computed dose during treatment planning. Methods: CT images of water surrounding metallic cylindrical rods made of aluminum, copper and iron were studied in terms of Hounsfield Units (HU) spread. Metal-induced artifacts were characterized in terms of HU/Volume Histogram (HVH) using the Pinnacle treatment planning system. Effects of OMAR on enhancing our ability to delineate organs on CT and subsequent dose computation were examined in nine (9) patients with hip implants and two (2) patients with breast tissue expanders. Results: Our study characterized water at 1000 HU with a standard deviation (SD) of about 20 HU. The HVHs allowed us to evaluate how the presence of metal changed the HU spread. For example, introducing a 2.54 cm diameter copper rod in water increased the SD in HU of the surrounding water from 20 to 209, representing an increase in artifacts. Subsequent use of OMAR brought the SD down to 78. Aluminum produced least artifacts whereas Iron showed largest amount of artifacts. In general, an increase in kVp and mA during CT scanning showed better effectiveness of OMAR in reducing artifacts. Our dose analysis showed that some isodose contours shifted by several mm with OMAR but infrequently and were nonsignificant in planning process. Computed volumes of various dose levels showed <2% change. Conclusions: In our experience, OMAR software greatly reduced the metal-induced CT artifacts for the majority of patients with implants, thereby improving our ability to delineate tumor and surrounding organs. OMAR had a clinically negligible effect on computed dose within tissues. Partially funded by unrestricted educational grant from Philips.

  2. Rice Diseases

    E-Print Network [OSTI]

    Jones, Roger K.

    1987-01-01

    Alzheimer's disease (AD) is the most common form of the dementia in the aging population. ?-amyloid peptide (A?) has been indicated as the most important hallmark of AD and also is believed to be the central trigger of ...

  3. Costs and benefits of maternally derived immunity in a game bird system 

    E-Print Network [OSTI]

    Ellis, Matthew B.

    2010-01-01

    This thesis examines the costs and benefits of maternal allocation to both mother and offspring in gamebirds, specifically ring necked pheasants (Phasianus colchicus) and the Chinese painted quail (Coturnix chinensis). ...

  4. Dynamic patterning of maternal mRNAs in the Early C. elegans embryo

    E-Print Network [OSTI]

    Li, Jialing, Ph. D. Massachusetts Institute of Technology

    2012-01-01

    Asymmetric segregation of maternally-encoded proteins is essential to cell fate determination during early cell divisions of the Caenorhabditis elegans (C. elegans) embryo, but little is known about the patterning of ...

  5. Maternal exposure to cadmium during gestation perturbs the vascular system of the adult rat offspring

    SciTech Connect (OSTI)

    Ronco, Ana Maria, E-mail: amronco@inta.cl [Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology (INTA), University of Chile, Casilla 138-11, Santiago (Chile); Montenegro, Marcela; Castillo, Paula; Urrutia, Manuel [Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology (INTA), University of Chile, Casilla 138-11, Santiago (Chile); Saez, Daniel [Faculty of Veterinary Medicine, University of Chile, Casilla 138-11, Santiago (Chile); Hirsch, Sandra [Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology (INTA), University of Chile, Casilla 138-11, Santiago (Chile); Zepeda, Ramiro [Faculty of Medicine, University of Chile, Casilla 138-11, Santiago (Chile); Llanos, Miguel N. [Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology (INTA), University of Chile, Casilla 138-11, Santiago (Chile)

    2011-03-01

    Several cardiovascular diseases (CVD) observed in adulthood have been associated with environmental influences during fetal growth. Here, we show that maternal exposure to cadmium, a ubiquitously distributed heavy metal and main component of cigarette smoke is able to induce cardiovascular morpho-functional changes in the offspring at adult age. Heart morphology and vascular reactivity were evaluated in the adult offspring of rats exposed to 30 ppm of cadmium during pregnancy. Echocardiographic examination shows altered heart morphology characterized by a concentric left ventricular hypertrophy. Also, we observed a reduced endothelium-dependent reactivity in isolated aortic rings of adult offspring, while endothelium-independent reactivity remained unaltered. These effects were associated with an increase of hem-oxygenase 1 (HO-1) expression in the aortas of adult offspring. The expression of HO-1 was higher in females than males, a finding likely related to the sex-dependent expression of the vascular cell adhesion molecule 1 (VCAM-1), which was lower in the adult female. All these long-term consequences were observed along with normal birth weights and absence of detectable levels of cadmium in fetal and adult tissues of the offspring. In placental tissues however, cadmium levels were detected and correlated with increased NF-{kappa}B expression - a transcription factor sensitive to inflammation and oxidative stress - suggesting a placentary mechanism that affect genes related to the development of the cardiovascular system. Our results provide, for the first time, direct experimental evidence supporting that exposure to cadmium during pregnancy reprograms cardiovascular development of the offspring which in turn may conduce to a long term increased risk of CVD.

  6. Beryllium disease

    SciTech Connect (OSTI)

    Not Available

    1991-12-20

    After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

  7. Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratio

    SciTech Connect (OSTI)

    Taylor, Kira C. [Division of Epidemiology, Statistics and Prevention Research, National Institutes of Child Health and Development (NICHD), NIH, DHHS, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852 (United States); Department of Epidemiology, 1518 Clifton Road, NE Atlanta, GA 30322 (United States); Jackson, Leila W. [Department of Epidemiology and Biostatistics, WG37, Case Western Reserve University School of Medicine, 10900 Euclid Avenue Cleveland, OH 44106-4945 (United States); Lynch, Courtney D. [Division of Epidemiology, Statistics and Prevention Research, National Institutes of Child Health and Development (NICHD), NIH, DHHS, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852 (United States); Kostyniak, Paul J. [Toxicology Research Center, 134 Cary Hall, University at Buffalo, State of New York, 3434 Main St., Buffalo, NY 14214-3000 (United States); Buck Louis, Germaine M. [Division of Epidemiology, Statistics and Prevention Research, National Institutes of Child Health and Development (NICHD), NIH, DHHS, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852 (United States)]. E-mail: louisg@mail.nih.gov

    2007-01-15

    The secondary sex ratio is the ratio of male to female live births and historically has ranged from 102 to 106 males to 100 females. Temporal declines have been reported in many countries prompting authors to hypothesize an environmental etiology. Blood specimens were obtained from 99 women aged 24-34 prior to attempting pregnancy and quantified for 76 polychlorinated biphenyl (PCB) congeners using dual column gas chromatography with electron capture detection. Women were prospectively followed until pregnancy or 12 cycles of trying. The odds of a male birth for three PCB groupings (total, estrogenic, anti-estrogenic) controlling for maternal characteristics were estimated using logistic regression. Among the 50 women with live births and PCB data, 26 female and 24 male infants were born (ratio 0.92). After adjusting for age and body mass index, odds of a male birth were elevated among women in the second (OR=1.29) and third (OR=1.48) tertiles of estrogenic PCBs; odds (OR=0.70) were reduced among women in the highest tertile of anti-estrogenic PCBs. All confidence intervals included one. The direction of the odds ratios in this preliminary study varied by PCB groupings, supporting the need to study specific PCB patterns when assessing environmental influences on the secondary sex ratio.

  8. Maternal exposure to metals—Concentrations and predictors of exposure

    SciTech Connect (OSTI)

    Callan, A.C., E-mail: a.callan@ecu.edu.au [Centre for Ecosystem Management, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027 (Australia); Hinwood, A.L.; Ramalingam, M.; Boyce, M. [Centre for Ecosystem Management, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027 (Australia)] [Centre for Ecosystem Management, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027 (Australia); Heyworth, J. [School Population Health, The University of Western Australia, 35 Stirling Highway Crawley, WA 6009 (Australia)] [School Population Health, The University of Western Australia, 35 Stirling Highway Crawley, WA 6009 (Australia); McCafferty, P. [ChemCentre, PO Box 1250, Bentley, WA 6983 (Australia)] [ChemCentre, PO Box 1250, Bentley, WA 6983 (Australia); Odland, J.Ø. [Department of Community Medicine, University of Tromsø, N-9037 Tromsø (Norway)] [Department of Community Medicine, University of Tromsø, N-9037 Tromsø (Norway)

    2013-10-15

    A variety of metals are important for biological function but have also been shown to impact health at elevated concentrations, whereas others have no known biological function. Pregnant women are a vulnerable population and measures to reduce exposure in this group are important. We undertook a study of maternal exposure to the metals, aluminium, arsenic, copper, cobalt, chromium, lithium, manganese, nickel, selenium, tin, uranium and zinc in 173 participants across Western Australia. Each participant provided a whole blood and urine sample, as well as drinking water, residential soil and dust samples and completed a questionnaire. In general the concentrations of metals in all samples were low with the notable exception of uranium (blood U mean 0.07 µg/L, range <0.01–0.25 µg/L; urinary U mean 0.018 µg/g creatinine, range <0.01–0.199 µg/g creatinine). Factors that influenced biological concentrations were consumption of fish which increased urinary arsenic concentrations, hobbies (including mechanics and welding) which increased blood manganese concentrations and iron/folic acid supplement use which was associated with decreased concentrations of aluminium and nickel in urine and manganese in blood. Environmental concentrations of aluminium, copper and lithium were found to influence biological concentrations, but this was not the case for other environmental metals concentrations. Further work is underway to explore the influence of diet on biological metals concentrations in more detail. The high concentrations of uranium require further investigation. -- Highlights: • High concentrations of uranium with respect to international literature. • Environmental concentrations of Al, Cu and Li influenced urinary concentrations. • Exposure to mechanics/welding hobbies increased blood Mn concentrations. • Iron/Folic acid supplements reduced biological concentrations of Al, Ni and Mn.

  9. Population consequences of maternal effects: sex-bias in egg-laying order facilitates divergence in sexual dimorphism between

    E-Print Network [OSTI]

    Badyaev, Alex

    in sexual dimorphism between bird populations A. V. BADYAEV,* G. E. HILL & L. A. WHITTINGHAMà *Division Keywords: egg-laying order; growth; maternal effects; population divergence; sex-ratio; sexual dimorphism of these maternal adjustments was fast phenotypic change in sexual size dimorphism within and between populations

  10. MAVIDOS Maternal Vitamin D Osteoporosis Study: study protocol for a randomized controlled trial.

    E-Print Network [OSTI]

    Harvey, Nicholas C.; Javaid, Kassim; Bishop, Nicholas; Kennedy, Stephen; Papageorghiou, Aris T.; Fraser, Robert; Gandhi, Saurabh V.; Schoenmakers, Inez; Prentice, Ann; Cooper, Cyrus

    2012-02-07

    Maternal Vitamin D Osteoporosis Study: study protocol for a randomized controlled trial. The MAVIDOS Study Group Nicholas C Harvey1, Kassim Javaid2, Nicholas Bishop3, Stephen Kennedy4, Aris T Papageorghiou4, Robert Fraser5, Saurabh V Gandhi5, Inez... ]. The effect of maternal 25(OH)- vitamin D status appeared to be partly mediated via concentrations of venous umbilical cord calcium, sug- gesting that placental calcium transfer to the fetus may be a critical step in these associations. Indeed mRNA expression...

  11. Socioeconomic Risk Moderates the Link Between Household Chaos and Maternal Executive Function

    E-Print Network [OSTI]

    .e., single parenthood, lower mother and father educational attainment, housing situation, and father in ecological contexts in the home and beyond (Bronfenbrenner & Ceci, 1994). Furthermore, these ecological socioeconomic risk factors, house- hold "chaos" (e.g., noise, distractions, disarray), and maternal cognitive

  12. Stimulus Control of Maternal Responsiveness to Norway Rat (Rattus norvegicus) Pup Ultrasonic Vocalizations

    E-Print Network [OSTI]

    Stimulus Control of Maternal Responsiveness to Norway Rat (Rattus norvegicus) Pup Ultrasonic be considered a specialization of Norway rats and other small rodents. When removed from the nest and placed in a cool environment, infant Norway rats emit USVs. These vocalizations range from 30 to 50 k

  13. Hydrocarbon Signatures of Egg Maternity, Caste Membership and Reproductive Status in the Common Wasp

    E-Print Network [OSTI]

    Wenseleers, Tom

    Hydrocarbon Signatures of Egg Maternity, Caste Membership and Reproductive Status in the Common-laid and worker-laid eggs has never been investigated. Our aim, therefore, was to investigate if hydrocarbons on the surface of newly-laid eggs, and that there are pronounced quantitative differences in the hydrocarbon

  14. Maternal Effects on Reproduction and Traits of Reciprocal F1 Dams of

    E-Print Network [OSTI]

    Ma, Lena

    Maternal Effects on Reproduction and Production Traits of Reciprocal F1 Dams of Angus, Brahman to determine if differences in their producing ability can be attributed to the breed of their dam. The purpose of this paper is to compare the performance of reciprocal F1 crossbred females as to dam breed for both

  15. Gaucher Disease Inherited disorder

    E-Print Network [OSTI]

    Brutlag, Doug

    , spleen, and bone marrow ¡ Many types ¡ Possible link to Parkinson's Disease ¡ Affects 1 in 100,000 #12/> ¡ "Gaucher Disease." Genetics Home Reference ­ Your Guide to Understanding Genetic Conditions. US National Disease." Gene Review. Web 2 Oct. 2012. Genetics

  16. The Edinburgh Royal Maternity Hospital and The Medicalisation of Childbirth in Edinburgh, 1844- I914: A Casebook-Centred Perspective 

    E-Print Network [OSTI]

    Nuttall, Alison M.

    This thesis examines the development of the Edinburgh Royal Maternity Hospital in the context of medical care in Edinburgh during the period 1844-1914. It is based primarily on casebooks of the hospital and, in particular, ...

  17. Interim Chronic Beryllium Disease

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-12-08

    Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

  18. Understanding Heart Disease

    E-Print Network [OSTI]

    Shen, Jun

    1 Understanding Heart Disease Vietnamese Aspire For Healthy Hearts What Is Heart Disease? Heart the blood vessels going to the heart become narrow and clogged. Blood vessels are long, hollow tubes arteries. When arteries become clogged, it increases the risk of developing heart disease. When the heart

  19. Wheat Diseases Atlas. 

    E-Print Network [OSTI]

    McCoy, Norman L.; Berry, Robert W.

    1982-01-01

    to wheat producers over the state on whose farms demonstrations have been conducted and pic tures for this publication were made. WhEAT DisEASES ATLAs Norman L. McCoy and Robert W Berry* INTRODUCTION Wheat diseases have caused untold human suffer ing...

  20. International Scholarly Research Network ISRN Orthopedics

    E-Print Network [OSTI]

    Azad, Abdul-Majeed

    in wound healing. In this work, TiO2 nanofibers were synthesized by electrospinning. Doping with iron

  1. Orthopedic Correction of Growing Retrognathic Hyperdivergent Patients 

    E-Print Network [OSTI]

    Carrillo, Roberto

    2014-05-13

    The purpose of this prospective study was to determine whether dental intrusion is effective in treating growing retrognathic hyperdivergent patients without negatively affecting the roots and periodontal structures. The ...

  2. Maternal diet-induced obesity programmes cardiovascular dysfunction in adult male mouse offspring independent of current body weight

    E-Print Network [OSTI]

    Blackmore, Heather L.; Niu, Youguo; Fernandez-Twinn, Denise S.; Tarry-Adkins, Jane L.; Giussani, Dino A.; Ozanne, Susan E.

    2014-07-18

    , Siggens L, et al. The pro- gramming of cardiac hypertrophy in the offspring by maternal obe- sity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation. Endocrinology. 2012;153(12):5961–5971. 14. Fan X, Turdi S, Ford SP, et al. Influence...

  3. Maternal Diet-induced Obesity Programs Cardiovascular Dysfunction in Adult Male Mouse Offspring Independent of Current Body Weight

    E-Print Network [OSTI]

    Blackmore, Heather L.; Niu, Youguo; Fernandez-Twinn, Denise S.; Tarry-Adkins, Jane L.; Giussani, Dino A.; Ozanne, Susan E.

    2014-07-22

    , Siggens L, et al. The pro- gramming of cardiac hypertrophy in the offspring by maternal obe- sity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation. Endocrinology. 2012;153(12):5961–5971. 14. Fan X, Turdi S, Ford SP, et al. Influence...

  4. A review of "Performing Maternity in Early Modern England" edited by Kathryn M. Moncrief and Kathryn R. McPherson 

    E-Print Network [OSTI]

    Bunker, Nancy M.

    2008-01-01

    the performances of maternity. Peter Shoemaker, Powerful Connections: The Poetics of Patronage in the Age of Louis XIII. Newark: University of Delaware Press, 2007. 291 pp. $60.00. Review by ge o f f r e y tu r n o v s k y , un i v e r s i t y o f wa s h i...

  5. Adventures in Infectious Diseases

    ScienceCinema (OSTI)

    Fisher-Hoch, Susan [University of Texas School of Public Health

    2014-06-25

    Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

  6. Chronic obstructive pulmonary disease, pulmonary function and cardiovascular disease 

    E-Print Network [OSTI]

    McAllister, David Anthony

    2011-07-05

    Cardiovascular disease is common in Chronic Obstructive Pulmonary Disease (COPD), and forced expiratory volume in one second (FEV1) independently predicts cardiovascular morbidity and mortality. Pathological changes in ...

  7. Osteocytes and Bone Diseases 

    E-Print Network [OSTI]

    Ren, Yinshi

    2015-05-06

    For many centuries, the osteoblast is considered to be responsible for bone formation. It is also believed that an imbalance of osteoblasts (weak) and osteoclasts (strong) is the main cause for bone diseases such as ...

  8. Health & Medicine Heart Disease

    E-Print Network [OSTI]

    Rogers, John A.

    See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

  9. Soybean Diseases Atlas. 

    E-Print Network [OSTI]

    Anonymous,

    1979-01-01

    new disease which causes root and stem rot to soybeans and other legumes in several southern states. The earliest sympt om is yellowing of leaves of individual plants or patches of plants across fields. Leaves of damaged plants usually develop... new soybean disease restricts root development and causes an absence of nitrogen-fixing nodules. Plants are stunted in an irregular pattern that may resemble manganese toxicity, or moisture or potash deficiency. High nematode populations often...

  10. Juggling Work and Motherhood: The Impact of Employment and Maternity Leave on Breastfeading Duration: A Survival Analysis on Growing Up in Scotland Data 

    E-Print Network [OSTI]

    Skafida, Valeria

    Abstract In 2005, Scotland became the first nation to make breastfeeding in public a legal right, but current breastfeeding targets and maternity leave allowance do not acknowledge the conflicting demands women face when ...

  11. Effects of postnatal and maternal diet-induced obesity on physiology and vascular function 

    E-Print Network [OSTI]

    Dakin, Rachel Sarah

    2012-11-30

    In recent years there has been an explosion in the rates of obesity, defined as a body mass index greater than 30kg/ m2, and associated cardiovascular disease. Alterations in peripheral glucocorticoid metabolism have ...

  12. Common Rose Diseases 

    E-Print Network [OSTI]

    Johnk, Janell

    2000-01-11

    is implied. 1. Plant roses in full sun.2. Use drip irrigation or soaker hoses. 3. Water in early morning.4. Selectively prune to open canopy and increase aircirculation. 5. Manage weeds and insects to prevent the spread of viruses. F i ve S te p..., making it moresusceptible to insect problems andother diseases.Management?Prune damaged orinfected canes . The black spot fungusover winters oncanes. Carefulpruning removesdamaged or infectedcanes and slowsdisease development. B lack Spot Rose varieties...

  13. Peanut Diseases Atlas. 

    E-Print Network [OSTI]

    Horne, Wendell C.

    1974-01-01

    Acknowledgments This publication was made possible by a grant from the Texas Peanut Producers Board to the Texas Agricultural Extension Service. This educational support in the area of peanut disease control is appreciated. The author also expresses... appreciation to producers who contributed through the voluntary check-off program and to those Extension staff members and research plant pathologists and nematologists who gave assistance and counsel during the prepara tion of this publication . Peanut...

  14. Inherited risk for common disease

    E-Print Network [OSTI]

    Banava, Helen

    2007-01-01

    Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

  15. Vannida Ket Disease Case Presentation

    E-Print Network [OSTI]

    Brutlag, Doug

    -Sachs disease is classically diagnosed by an eye examination or behavior observation. Ganglion cells in the eye

  16. PLANT DISEASES IN SOUTH CAROLINA

    E-Print Network [OSTI]

    Stuart, Steven J.

    INDEX OF PLANT DISEASES IN SOUTH CAROLINA James H. Blake, Ed.D. Director, Home & Garden Information to compile a list of plant diseases occurring on cultivated and native plants in South Carolina. The data or conclusive list of the diseases of plants in South Carolina. New plants as well as new plant pathogens

  17. A Manual of Poultry Diseases

    E-Print Network [OSTI]

    Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

    1965-01-01

    ............................................ Botlv Defense Against Disease 6 Manifestations of Disease ...................................................... 7 ........ Hatcherv and Breeder Flock Health Management 7 Hatchcrv Management and Sanitation ......... .... ........... 8 Principles... ......................................................... 10 Vaccination No Substitute for Sanitation .................... .. 11 Diseases for 'lIrhich Vaccines Are Available .................... 11 ....................... .................. Acl~ninistration of Vaccines ......... 11 -4 Suggested...

  18. The effect of a prolonged magnesium restriction on the humoral immune response in maternal rats and their offspring 

    E-Print Network [OSTI]

    Cohill, Diane T

    1987-01-01

    TIIE EFFECT 0F A PR0L0NGED MAGNESIUM RESTRI CTI0N ON THE HUMORAL IMMUNE RESPONSE IN HATERHAL RATS AHD THEIR OFFSPRING A Thesis by DIANE T. COHILL Submitted to the Graduate College of Texas ASM University in Partial fulfillment... of the requirements for the degree of MASTER OF SC IENCE May 1987 Major Subject: Nutrition THE EFFECT OF A PROLONGED MAGNESIUM RESTRICTION ON THE HUMORAL IMMUNE RESPONSE IN MATERNAL RATS AND THEIR OFFSPRING A Thesis by DIANE T. COHILL Approved as to sty le...

  19. Development of Graves' disease following radiation therapy in Hodgkin's disease

    SciTech Connect (OSTI)

    Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

    1988-01-01

    Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

  20. The etiology of loin disease 

    E-Print Network [OSTI]

    Greeley, Ralph Gordon

    1966-01-01

    treatment has been discovered and the etiology of the disease has never been proven. In South Africa a similar disease, larnsiekte, has been recorded for centuries. In the 1920's intensive research in that country un- covered a chain of conditions... the similarity of lamsiekte and loin disease, and of the phosphorus deficiency that soils of South Africa and the Texas coastal plains have in common. In 1924 he began recommending the routine supplemental feeding of phos- phorus to range cattle (8). Where...

  1. Using Wikipedia to forecast diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Molecular Biologist, of the Mathematical and Computational Epidemiology Team at Los Alamos National Laboratory Science Friday Interviews Mining Wikipedia Data to Track Disease...

  2. Developmental programming by maternal obesity in 2015: Outcomes, mechanisms, and potential interventions

    E-Print Network [OSTI]

    Penfold, Naomi C.; Ozanne, Susan E.

    2015-07-02

    evidence for an increased risk of non-alcoholic fatty liver 195 and pancreas diseases (NAFLD and NAFPD, respectively) in offspring of obese mothers, a pathology 196 which commonly occurs in obesity when the normal capacity of white adipose tissue... , insulin, leptin and ghrelin have all been implicated in brain development. The early life 445 programming of brain circuits [HIP ?hippocampus, HYP ?hypothalamus, ML ?mesolimbic pathway] 446 may contribute to altered energy balance, motivated and other...

  3. Environmental Contributions to Allergic Disease

    E-Print Network [OSTI]

    Levetin, Estelle

    with increased exposure to air pollution and indoor contaminants such as house dust mites, cockroaches disease is more complex than increased exposure to pollution and allergens and that early childhood of outdoor factors to allergic disease. Influence of Exposure to Pollutants on the Manifestation of Allergic

  4. Publications Fish Disease Diagnosis and

    E-Print Network [OSTI]

    Publications Fish Disease Diagnosis and Basic Fishery Computer Programs The second edition of "Disease Diagnosis and Control in North American Marine Aquaculture," edited by Carl J. Sindermann edition should be a big help to aquaculturists and others involved in the detection, prevention

  5. Occupational Disease in Connecticut, 2014

    E-Print Network [OSTI]

    Oliver, Douglas L.

    Occupational Disease in Connecticut, 2014 This report covers data for 2012 and was prepared under contract for the State of Connecticut Workers' Compensation Commission, John A. Mastropietro, Chairman, as part of the Occupational Disease Surveillance Program, operated in cooperation with the Connecticut

  6. Evolution of sex-biased maternal effects in birds: II. Contrasting sex-specific oocyte clustering in native and recently established

    E-Print Network [OSTI]

    Badyaev, Alex

    Evolution of sex-biased maternal effects in birds: II. Contrasting sex-specific oocyte clustering). In particular, sex differences in growth costs or requirements in viviparous species set the stage for the evolution of sex-biased parental strategies and sibling competition (Drummond et al., 1991; Lessells, 2002

  7. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  8. Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease

    E-Print Network [OSTI]

    Watts, Amber; Crimmins, Eileen M.; Gatz, Margaret

    2008-09-10

    Periodontal disease (PDD) is associated with increased risk of cardiovascular disease, cerebrovascular disease, and mortality in many studies, while other studies have begun to suggest an association of PDD with Alzheimer’s disease (AD). This paper...

  9. Alzheimer's Disease and Vitamin E

    E-Print Network [OSTI]

    Empey, Matthew

    1998-01-01

    Adelman A. Selegiline and vitamin E in Alzheimer's disease.bomb. Geriatrics Traber MG. Vitamin E in humans: Demand andJ, Cole GM, Schubert D. Vitamin E protects nerve cells from

  10. A Manual of Poultry Diseases

    E-Print Network [OSTI]

    Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

    1971-01-01

    ........................................................ 7 Flock Health Management 7 Hatchery Management and Sanitation ............................ 8 Principles of Reasonable Drug Administration ................. .... 9 Drug Administration... Vaccines Are ................................................................... 10 Dangers of Vaccination ........................................................... 10 Vaccination-No Substitute for Sanitation ..... .................... 11 Diseases...

  11. Prudent behaviour accelerates disease transmission

    E-Print Network [OSTI]

    Scarpino, Samuel V; Hebert-Dufresne, Laurent

    2015-01-01

    Infectious diseases often spread faster near their peak than would be predicted given early data on transmission. Despite the commonality of this phenomena, there are no known general mechanisms able to cause an exponentially spreading dis- ease to begin spreading faster. Indeed most features of real world social networks, e.g. clustering1,2 and community structure3, and of human behaviour, e.g. social distancing4 and increased hygiene5, will slow disease spread. Here, we consider a model where individuals with essential societal roles-e.g. teachers, first responders, health-care workers, etc.- who fall ill are replaced with healthy individuals. We refer to this process as relational exchange. Relational exchange is also a behavioural process, but one whose effect on disease transmission is less obvious. By incorporating this behaviour into a dynamic network model, we demonstrate that replacing individuals can accelerate disease transmission. Furthermore, we find that the effects of this process are trivial w...

  12. Diarrheal Disease in Show Swine 

    E-Print Network [OSTI]

    Lawhorn, D. Bruce

    2007-02-27

    from the feces of recovered car- rier pigs or from contaminated premises, trailers or scales. Pigs affected with this disease usually become very sick. This organism infects the cells lining the cecum and spiral colon (the same area as whipworms... disease in show pigs. Infection occurs after pigs ingest microscopic whipworm eggs while rooting or eating in a contaminat- ed environment. Whipworm eggs remain viable for as long as 6 years so contaminated premises are an impor- tant source of infection...

  13. Controlling Diseases on Ornamental Plants. 

    E-Print Network [OSTI]

    Horne, C. Wendell; Johnson, Jerral D.; Walla, Walter J.

    1979-01-01

    on elms and other shade trees. Mushroom-type fu ngal growths appear on trunk, limbs or roots near the soil surface. Rots may be present for several years before mushrooms ap pear. Tree becomes sus ceptible to wi nd damage. Plants may die back..., irises, lilies, narcissus and tulips. ROOT DISEASES Disease Cotton root rot (fungi) Crown gall Mushroom root rot Symptoms Small flowering plants die within a few days. Shrubs and trees die more slowly. Large trees may die within several...

  14. A descriptive analysis of updated information and an evaluation of the effects of non-response in a case-control study of breast cancer and maternal serum alpha-fetoprotein 

    E-Print Network [OSTI]

    Glendening, Elizabeth Noelle'

    1997-01-01

    The participants or their proxies of a case-control study of the relationship between maternal serum alpha-fetoprotein (AFP) and breast cancer (target population) were invited to complete a mail questionnaire to gather updated information about...

  15. the heart truth What is heart Disease?

    E-Print Network [OSTI]

    Shen, Jun

    the heart truth® for Women What is heart Disease? Coronary heart disease (CHD) is the most common form of heart disease. Usually referred to simply as "heart disease," it is a disorder of the blood vessels of the heart in which a waxy substance called plaque builds up in the coronary (heart) arteries

  16. 200 Plant Disease / Vol. 87 No. 2200 Disease Notes

    E-Print Network [OSTI]

    Pappu, Hanu R.

    Leaf Curl Begomoviruses from Pakistan. S. L. Shih, W. S. Tsai, and S. K. Green, The Asian Vegetable Disease Research Institute, National Agricultural Research Centre, Islamabad, Pakistan; M. A. Rezaian in Pakistan. One chili sample with leaf curl symptoms was collected in 1998 in Multan (Punjab Province

  17. MAR 384 -DISEASES OF AQUATIC ORGANISMS (3 credits)

    E-Print Network [OSTI]

    Allam, Bassem

    . Disease management 26. Advances in aquatic animal disease Part I (vaccination, probiotics) 27. Advances

  18. Patching genes to fight disease

    SciTech Connect (OSTI)

    Holzman, D.

    1990-09-03

    The National Institutes of Health has approved the first gene therapy experiments, one of which will try to cure cancer by bolstering the immune system. The applications of such therapy are limited, but the potential aid to people with genetic diseases is great.

  19. Disease Management in Organic Plantings

    E-Print Network [OSTI]

    Isaacs, Rufus

    cooling or proper drying · Clean harvesting and processing equipment · Control insects that may createGard (Gliocladium virens) Blight Ban (Pseudomonas fluorescens) PlantShield (Trichoderma harzianum) Agri Antibiotics for control of bacterial diseases #12;Effect of Trichoderma hamatum (T382) in potting mix

  20. Easy Gardening.....Disease Control 

    E-Print Network [OSTI]

    Johnson, Jerral; Johnson, Jerral

    2009-05-29

    on plant roots and cause stunted plants. The most damaging nematode in the home garden is root knot. It causes galls or knots on susceptible plants such as toma- A good home gardener recognizes the symptoms of plant diseases quickly and takes steps...

  1. Social Cognition in Frontotemporal Dementia, Motor Neurone Disease, and Alzheimer's Disease 

    E-Print Network [OSTI]

    Oliver, Lindsay

    2011-11-23

    cognition across a number of neurodegenerative diseases, a test battery and two questionnaires were administered to frontal variant frontotemporal dementia (fvFTD), motor neurone disease (MND), Alzheimer`s disease, and healthy control participant groups...

  2. Why Do We Get Alzheimer's Disease?

    SciTech Connect (OSTI)

    Wyss-Coray, Tony (Stanford University) [Stanford University

    2006-01-02

    Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

  3. Fall Semester Credits N503 Biomedical Foundations of Health and Disease* -

    E-Print Network [OSTI]

    Lee, Daeyeol

    in Maternal-Newborn Nursing** 2 N518b or c Clinical Practice in Pediatric Nursing** 2 N519b or c Seminar in Pediatric Nursing** 2 N520b Clinical Practice in Psychiatric-Mental Health Nursing 2 N521b Seminar in Maternal-Newborn Nursing** - N518b or c Clinical Practice in Pediatric Nursing** - N519b or c Seminar

  4. Best Management Practices for Equine Disease Prevention 

    E-Print Network [OSTI]

    Scott, Brett D.

    2008-10-06

    AnimalDiseases,Revised1998] SchoolofVeterinaryMedicine,UniversityofWisconsin- Madison. Zoonotic Diseases Tutorial. www.vetmed.wisc.edu/pbs/zoonoses Hammer,Carolyn,2005, Equine Biological Risk Management.IowaStateUniversity. www.cfsph.iastate.edu Griffin...

  5. Karnal Bunt: A Disease of Wheat 

    E-Print Network [OSTI]

    Schuster, Greta; Krausz, Joseph P.; Rush, Charlie

    2002-11-20

    Karnal bunt is a fungal disease that affects wheat, durum wheat and triticale. This publication explains the life cycle of the disease, how it spreads, and methods of control....

  6. Does Drinking Tea Protect Against Cardiovascular Disease?

    E-Print Network [OSTI]

    Thompson, Natasha

    2003-01-01

    Maclure M, Muller JE et al. Tea consumption and mortalityU, Poole C, Arab L. Does Tea Affect Cardiovascular Disease?al. Regular Ingestion of black tea improves brachial artery

  7. New Clues in Predicting Alzheimer's Disease

    ScienceCinema (OSTI)

    Jagust, William

    2013-05-29

    Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

  8. MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW

    E-Print Network [OSTI]

    Missouri-Rolla, University of

    , coughing and having close social contact (living in the same household) are examples of how this disease

  9. SAGE-Hindawi Access to Research Advances in Orthopedics

    E-Print Network [OSTI]

    Azad, Abdul-Majeed

    with TiO2 nanocrystals or nanotubes as means of effective disinfectants for the prevention of major structure of photoactive TiO2 on the surface of Ti plates and wires is described. The nanoscale TiO2 films at least 50% reduction in the population of E. coli colonies (concentration 2.15 × 107 cells/mL) on TiO2

  10. Biomarker for Lung and Inflammatory Diseases

    E-Print Network [OSTI]

    Heydari, Payam

    Biomarker for Lung and Inflammatory Diseases Tech ID: 23381 / UC Case 2012-660-0 BACKGROUND and clinical research. We describe herein a novel biomarker and method of detecting interstitial lung disease have discovered that patients with interstitial lung and intestinal inflammatory diseases, for example

  11. Linkage Disequilibrium Mapping and Parkinson's Disease

    E-Print Network [OSTI]

    Parkinson's Disease Genetics Study Group, Science 279, 1116 (1998); T. Lynch et al., ibid., 278, 1212 (1997Linkage Disequilibrium Mapping and Parkinson's Disease Several investigators (1) have questioned with Parkinson's disease (PD) in four appar- ently unrelated Italian and Greek families, may be a cause

  12. Akt Isoforms in Vascular Disease

    E-Print Network [OSTI]

    Yu, Haixiang; Littlewood, Trevor; Bennett, Martin

    2015-04-28

    aneurysm; eNOS, endothelial nitric oxide synthase;mTOR,mammalian target of rapamycin. 44 1223 331505. . This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). orms in vascular disease, Vascul. Pharmacol. (2015... p85 subunit and a catalytic p110 subunit that directly phosphorylates the ribosomal protein kinase p70s6k [29], the rho family polypeptide Rac [30], the serum and glucocorticoid-induced kinases SGK [31–33], and the serine/threonine kinase Akt [34...

  13. Diseases of Peaches and Plums. 

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01

    the possibility of root injury during cultivation as much as possible. Mushroom Root Rot Mushroom root rot is a fungal disease commonly known as "post oak root rot," "shoestring root rot" or "mushroom root rot." It attacks peach, pear, plum, apple and many... trees. Do not replant trees in old orchard sites infested with mushroom root rot. Cotton Root Rot Peach and plum trees die suddenly after show ing first symptoms of wilting. When roots are pulled from the soil, the bark is decayed, and covered...

  14. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

    2008-10-21

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  15. Major Oak Diseases and Their Control. 

    E-Print Network [OSTI]

    Johnson, Jerral D.; Appel, David N.

    1984-01-01

    in many areas where oaks are the predominant native tree species. Research shows that much of this mortality is due to disease-causing organisms or disease complexes 10- volving environmental stress and pathogens. FOLIAR DISEASES Anthracnose (Fungus... tor nado, hurricane, severe hail or following a period of mechanical activity around oak trees. Heavy equip- ment working around trees can create large wounds. When this occurs, insects are attracted to the site and may be carrying the wilt...

  16. Diseases of Small Grains in Texas. 

    E-Print Network [OSTI]

    Atkins, I. M.; Futrell, M. C.

    1958-01-01

    Diseases - of SMALL GRAINS in cooperation with the UNITED STATES DEPARTMENT OF AGRICULTURE TEXAS AGRICULTURAL EXPERIMENT STATION R. D. LEWIS, DIRECTOR. COLLEGE STATIOKJ. TEXAS DIGEST CONTENTS 1 Diseases of small grains are important factors... and international signif- icance. The fall infection, winter survival and spring increase in South Texas of airborne pathogens, such as the cereal rusts, may endanger the small grain crops throughout Texas and other states. Diseases of wheat, which consistently...

  17. Mathematical Model Applications to Disease and Homeland ...

    E-Print Network [OSTI]

    Mathematical Model Applications to Disease and Homeland Security The events of ... but have no data or reliable information that would help in the planning or ...

  18. HANFORD THYROID DISEASE STUDY FINAL REPORT

    E-Print Network [OSTI]

    HANFORD THYROID DISEASE STUDY FINAL REPORT Study Management Team Scott Davis, Ph.D., Principal Gilman, Jennifer Sporleder, Jan Kikuchi, Bill Mullin, Liza Noonan, Chuck Wiggins, Belen Gallardo

  19. "Artificial" brains, electrical grids, and disease modeling:...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science discoveries unveiled "Artificial" brains, electrical grids, and disease modeling: Los Alamos science discoveries unveiled September 15 The event is an opportunity for...

  20. Relationships of Maternal and Paternal Anthropometry With Neonatal Body Size, Proportions and Adiposity in an Australian Cohort

    E-Print Network [OSTI]

    Pomeroy, Emma; Wells, Jonathan C. K.; Cole, Tim J.; O'Callaghan, Michael; Stock, Jay T.

    2014-12-13

    - tion (Lummaa, 2003) and adult disease risk (Hales and Barker, 1992; Barker, 1998). Given the extensive implica- tions of early growth and development, we might expect the prenatal period to be an important stage at which parental genetic, epigenetic... research nurse (Keeping, 1981; McGrath et al., 2005) within 24 h of birth. No data on inter-rater reliability are available. The neonatal measurements in this analysis were: birth- weight; head, abdominal, upper arm, lower arm, thigh and lower leg...

  1. Coenzyme Q10 prevents insulin signaling dysregulation and inflammation prior to development of insulin resistance in male offspring of a rat model of poor maternal nutrition and accelerated postnatal growth

    E-Print Network [OSTI]

    Tarry-Adkins, Jane; Fernandez-Twinn, Denise; Madsen, Ralitsa; Chen, Jian-Hua; Carpenter, Asha; Hargreaves, Iain; McConnell, Josie; Ozanne, Susan

    2015-07-27

    inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomised clinical trial. Nutr Neurosci. 2015;18:169–176. 41. Tarry-Adkins JL, Chen JH, Smith NS, Jones RH, Cherif H, Ozanne SE. Poor maternal nutrition followed...

  2. Disease management Applying Stylet Oil, Sulforix or

    E-Print Network [OSTI]

    Isaacs, Rufus

    1 Disease management Applying Stylet Oil, Sulforix or Armicarb now to vines with powdery mildew will reduce disease pressure next year. Do not apply Sulforix to sulfur-sensitive grapes. Bunch rots are best controlled by leaf pulling, but application of Fungastop may help reduce sour rot. Insect management Low

  3. What You Should Know About Plant Diseases

    E-Print Network [OSTI]

    Horne, C. Wendell; Smith, Harlan E.

    1962-01-01

    lodge, the grain is shrivelled and yields are low. The disease movement is shown in figure 6. " Seedling Disease ig. 7. See, caused b - -.-!.. ~. &> dling dise; y a comp' L , ase of cot1 lex of mic 11, *L^ -1. .fore its el tter it emf...

  4. Combined effects of perfluorooctane sulfonate (PFOS) and maternal restraint stress on hypothalamus adrenal axis (HPA) function in the offspring of mice

    SciTech Connect (OSTI)

    Ribes, Diana; Fuentes, Silvia; Torrente, Margarita; Colomina, M. Teresa [Department of Psychology and Research Center for Behavioral Assessment (CRAMC), 'Rovira i Virgili' University, Sescelades Campus, 43007 Tarragona, Catalonia (Spain); Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, 'Rovira i Virgili' University, Sant Llorenc 21, 43201 Reus, Catalonia (Spain); Domingo, Jose L., E-mail: joseluis.domingo@urv.ca [Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, 'Rovira i Virgili' University, Sant Llorenc 21, 43201 Reus, Catalonia (Spain)

    2010-02-15

    Although it is known that prenatal exposure to perfluorooctane sulfonate (PFOS) can cause developmental adverse effects in mammals, the disruptive effects of this compound on hormonal systems are still controversial. Information concerning the effects of PFOS on hypothalamus adrenal (HPA) axis response to stress and corticosterone levels is not currently available. On the other hand, it is well established that stress can enhance the developmental toxicity of some chemicals. In the present study, we assessed the combined effects of maternal restraint stress and PFOS on HPA axis function in the offspring of mice. Twenty plug-positive female mice were divided in two groups. Animals were given by gavage 0 and 6 mg PFOS/kg/day on gestation days 12-18. One half of the animals in each group were also subjected to restraint stress (30 min/session, 3 sessions/day) during the same period. Five plug-positive females were also included as non-manipulated controls. At 3 months of age, activity in an open-field and the stress response were evaluated in male and female mice by exposing them to 30 min of restraint stress. Male and female offspring were subsequently sacrificed and blood samples were collected to measure changes in corticosterone levels at four different moments related to stress exposure conditions: before stress exposure, immediately after 30 min of stress exposure, and recuperation levels at 60 and 90 min after stress exposure. Results indicate corticosterone levels were lower in mice prenatally exposed to restraint. In general terms, PFOS exposure decreased corticosterone levels, although this effect was only significant in females. The recuperation pattern of corticosterone was mainly affected by prenatal stress. Interactive effects between PFOS and maternal stress were sex dependent. The current results suggest that prenatal PFOS exposure induced long-lasting effects in mice.

  5. The implications of human metabolic network topology for disease comorbidity

    E-Print Network [OSTI]

    of different (and often disease-causing) genetic and epigenetic variations are not restricted but may spread, certain diseases, such as diabetes and obesity, or Gaucher disease and Parkinson disease, often cooccurThe implications of human metabolic network topology for disease comorbidity D.-S. Lee* , J. Park

  6. Disease Prevention in the Home Garden. 

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01

    . 12. Rotation. Avoid soil disease buildup. ?13. Insect control. Prevent virus spread. 14. Proper harvesting. Avoid storage decay. 15. Sanitation. Prevent buildup of diseased plant tissue in garden. 16. Fungicide application. Control diseases should...H to approximately 5.2; 10 Ibs. of sulfur per 1000 sq . ft. d rops the pH .5. Examp le: Ori- ginal pH 7.5; desired pH 5.5; 40 Ibs. of sulfur requ ired to adjust pH 3. Ring rot Bacterium I nfected seed pieces Introduction of Rotation and sanitation Equipment...

  7. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general populationAging is the primary risk factor for the majority of neurodegenerative diseases, including

  8. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general population James Parkinson first described the clinical symptoms of Parkinson's disease (PD) in his 1817 monograph

  9. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general population array of neurobiological disorders, including Parkinson's disease, epilepsy, essential tremor, Tourette

  10. Behavioral impulsivity and hallucinations : insights from Parkinson's disease

    E-Print Network [OSTI]

    Ashourian, Paymon

    2011-01-01

    Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

  11. Study of collagen structure in canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Hadian, Mojtaba

    2009-01-01

    Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs, and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans ...

  12. Epidemiology and evolution of Marek’s Disease virus 

    E-Print Network [OSTI]

    Atkins, Katherine E.

    2010-01-01

    Marek’s disease (MD) is an oncogenic disease affecting chickens and is estimated to cost the worldwide poultry industry $1-2 billion annually. The causative agent of MD, Marek’s disease virus (MDV), provides a ...

  13. HLB in Argentina: a New Disease Outbreak

    E-Print Network [OSTI]

    2014-01-01

    Vol. 1 (2014) HLB in Argentina: a New Disease Outbreak Outi,E. 6 SENASA, Bs. As. Argentina MAGyP Bs. As INTA Montecarlo,Paraná, 300 km away from Argentina’s Northeastern border. In

  14. Metabolomics reveals metabolic biomarkers of Crohn's disease

    SciTech Connect (OSTI)

    Jansson, J.K.; Willing, B.; Lucio, M.; Fekete, A.; Dicksved, J.; Halfvarson, J.; Tysk, C.; Schmitt-Kopplin, P.

    2009-06-01

    The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention.

  15. Management of cotton seedling disease complexes 

    E-Print Network [OSTI]

    Fichtner, Scott Michael

    2001-01-01

    The objective of this research was to evaluate combinations of approaches for the management of seedling diseases of cotton caused by soilborne pathogens, including the use of host resistance. Over 200 cotton lines were ...

  16. MFR PAPER 1208 Minchinia nelsoni (MSX) Disease

    E-Print Network [OSTI]

    of the disease in each of these areas has been thoroughly stud- 22 ied and reported (Haskin et aI., 1965; Andrews, 1966, 1968; Rosenfield and Sindermann, 1966; Andrews and Wood, 1967; Couch and Rosenfield, 1968; Ford

  17. Is chytridiomycosis an emerging disease in Asia?

    E-Print Network [OSTI]

    Brown, Rafe M.

    2011-01-01

    Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 26Museo Nacional de Ciencias Naturales, Madrid, Spain Abstract The disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has caused dramatic... Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 26Museo Nacional de Ciencias Naturales, Madrid, Spain Abstract The disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has caused dramatic...

  18. How should environmental stress affect the population dynamics of disease?

    E-Print Network [OSTI]

    Holt, Robert D.

    in pollution (Khan 1990), malnutrition (Beck & Levander 2000) and thermal stress from climate change (Harvell and disease in natural populations. Keywords Disease, dynamics, host, infectious, model, pollution, population

  19. ATTACHMENT 1: HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    : HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM (CBDPP) COMMITTEE CHARTER The Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP) Committee is established...

  20. Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease 

    E-Print Network [OSTI]

    Vaughan-Dark, Chelsea Ann

    2013-07-17

    This study assesses generic and disease-specific Health-Related Quality of Life (HRQOL) in children and adolescents with Inflammatory Bowel Disease (IBD). More specifically, the purpose of the study is to address the relationship between disease...

  1. Photo-environment affects disease progression in bacterial artificial chromosome (BAC) Huntington s disease mouse model

    E-Print Network [OSTI]

    HUEI-BIN, WANG,

    2015-01-01

    OF CALIFORNIA Los Angeles Photo-environment affects diseaseABSTRACT OF THE THESIS Photo-environment affects diseaseshow that inappropriate photo-environment such as constant

  2. Transgenic Mouse Model of Chronic Beryllium Disease

    SciTech Connect (OSTI)

    Gordon, Terry

    2009-05-26

    Animal models provide powerful tools for dissecting dose-response relationships and pathogenic mechanisms and for testing new treatment paradigms. Mechanistic research on beryllium exposure-disease relationships is severely limited by a general inability to develop a sufficient chronic beryllium disease animal model. Discovery of the Human Leukocyte Antigen (HLA) - DPB1Glu69 genetic susceptibility component of chronic beryllium disease permitted the addition of this human beryllium antigen presentation molecule to an animal genome which may permit development of a better animal model for chronic beryllium disease. Using FVB/N inbred mice, Drs. Rubin and Zhu, successfully produced three strains of HLA-DPB1 Glu 69 transgenic mice. Each mouse strain contains a haplotype of the HLA-DPB1 Glu 69 gene that confers a different magnitude of odds ratio (OR) of risk for chronic beryllium disease: HLA-DPB1*0401 (OR = 0.2), HLA-DPB1*0201 (OR = 15), HLA-DPB1*1701 (OR = 240). In addition, Drs. Rubin and Zhu developed transgenic mice with the human CD4 gene to permit better transmission of signals between T cells and antigen presenting cells. This project has maintained the colonies of these transgenic mice and tested the functionality of the human transgenes.

  3. Chronic beryllium disease: Diagnosis and management

    SciTech Connect (OSTI)

    Rossman, M.D.

    1996-10-01

    Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4{sup +} T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease. 21 refs.

  4. Global disease monitoring and forecasting with Wikipedia

    SciTech Connect (OSTI)

    Generous, Nicholas; Fairchild, Geoffrey; Deshpande, Alina; Del Valle, Sara Y.; Priedhorsky, Reid; Salathé, Marcel

    2014-11-13

    Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data, such as social media and search queries, are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: access logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.

  5. Global disease monitoring and forecasting with Wikipedia

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Generous, Nicholas; Fairchild, Geoffrey; Deshpande, Alina; Del Valle, Sara Y.; Priedhorsky, Reid; Salathé, Marcel

    2014-11-13

    Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data, such as social media and search queries, are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: accessmore »logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.« less

  6. 788 Plant Disease / Vol. 83 No. 9 Snow mold diseases are caused by fungi

    E-Print Network [OSTI]

    Hsiang, Tom

    788 Plant Disease / Vol. 83 No. 9 Snow mold diseases are caused by fungi that grow and attack limit the activity and number of com- petitors and antagonists of snow mold fungi, and allow these pathogens to mo- nopolize the nutrient-rich but weakened plant tissues (42). Most snow mold fungi that have

  7. An immuno-epidemiological model for Johne's disease in cattle

    E-Print Network [OSTI]

    Martcheva, Maia

    An immuno-epidemiological model for Johne's disease in cattle Maia Martcheva1 Email: maia's disease in dairy cattle, this paper illustrates a novel way to link a within-host model for Mycobacterium reproduction model. Introduction Johne's disease (JD) in dairy cattle is a chronic infectious disease

  8. interdisciplinary Glyphosate, pathways to modern diseases II

    E-Print Network [OSTI]

    Seneff, Stephanie

    rashes, depression, and nutrient deficiencies. Usually, but not always, a strict gluten-free diet caninterdisciplinary Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North

  9. ISSUE 58 APRIL 2009 Will coeliac disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 58 APRIL 2009 Will coeliac disease always mean gluten-free? Pen-pushers Meet the winning is to deliver a free, Darwin-inspired experiment to every schoolchild in the country. For primary schools, we of the Wellcome Trust Wellcome News Wellcome News is published four times a year and is available free of charge

  10. Centers for Disease Control and Prevention (CDC)

    E-Print Network [OSTI]

    and Terrorism and Director of Global Health Activities for the Division of Environmental Hazards and Health based environmental health assessments #12;Government Agencies Visited · The United States AgencyCenters for Disease Control and Prevention (CDC) National Center for Environmental Health CDC

  11. DISEASE-SPECIFIC PROBABILISTIC BRAIN ATLASES

    E-Print Network [OSTI]

    Thompson, Paul

    algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining School of Medicine, Los Angeles, CA 2 Alzheimer's Disease Center, UCLA School of Medicine, Los Angeles Westwood Plaza, Los Angeles, CA 90095-1769 Phone: (310) 206-2101 Fax: (310) 206-5518 E-mail: thompson

  12. Injury vs Disease Lifestyles of pathogens

    E-Print Network [OSTI]

    Nowak, Robert S.

    of plant disease Nematodes alone cost ~$100 billions worldwide In the US, yearly cost ~ $15 billions #12 of temperature 3 Days After #12;#12;Effects of wind Mostly dispersal of pathogens In some cases, wind can prevent the development of new infections because it dries the surface of plants Wind can cause injury

  13. Injury vs Disease Lifestyles of pathogens

    E-Print Network [OSTI]

    Nowak, Robert S.

    In the US, yearly cost ~ $15 billions #12;4/29/2015 15 Impacts of plant disease In a worldwide scale 27 of wind Mostly dispersal of pathogens In some cases, wind can prevent the development of new infections because it dries the surface of plants Wind can cause injury (mechanical abrasion) Effects of temperature

  14. Genetically Determined Height and Coronary Artery Disease

    E-Print Network [OSTI]

    Nelson, Christopher P.; Hamby, Stephen E.; Saleheen, Danish; Hopewell, Jenna C.; Zeng, Lingyao; Assimes, Themistocles L.; Kanoni, Stavroula; Willenborg, Christina; Burgess, Stephen; Amouyel, Philippe; Anand, Sonia; Blankenberg, Stefan; Boehm, Bernhard O.; Clarke, Robert J.; Collins, Rory; Dedoussis, George; Farrall, Martin; Franks, Paul W.; Groop, Leif; Hall, Alistair S.; Hamsten, Anders; Hengstenberg, Christian; Hovingh, G. Kees; Ingelsson, Erik; Kathiresan, Sekar; Kee, Frank; König, Inke R.; Kooner, Jaspal; Lehtimäki, Terho; März, Winifred; McPherson, Ruth; Metspalu, Andres; Nieminen, Markku S.; O'Donnell, Christopher J.; Palmer, Colin N.A.; Peters, Annette; Perola, Markus; Reilly, Muredach P.; Ripatti, Samuli; Roberts, Robert; Salomaa, Veikko; Shah, Svati H.; Schreiber, Stefan; Siegbahn, Agneta; Thorsteinsdottir, Unnur; Veronesi, Giovani; Wareham, Nicholas J.; Willer, Cristen J.; Zalloua, Pierre A.; Erdmann, Jeanette; Deloukas, Panos; Watkins, Hugh; Schunkert, Heribert; Danesh, John; Thompson, John R.; Samani, Nilesh J.

    2015-04-23

    of Tampere, Tampere (T.L.), and the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital (M.S.N.), Department of Chronic Disease Prevention, National Institute for Health and Welfare (M.P., V.S.), and Hjelt Institute The New...

  15. 3301DEVELOPMENT AND DISEASE RESEARCH ARTICLE INTRODUCTION

    E-Print Network [OSTI]

    Gibson, Matt

    smooth muscle cells (SMC) and SM pathology is associated with several diseases, including asthma, lung the urinary bladder, and a failure of this activity causes `functional' flow impairment leading to urinary tract may be an important primary cause of functional obstruction and hydronephrosis. Between mouse

  16. Treatment of Anthrax Disease Frequently Asked Questions

    SciTech Connect (OSTI)

    Judd, Kathleen S.; Young, Joan E.; Lesperance, Ann M.; Malone, John D.

    2010-05-14

    This document provides a summary of Frequently Asked Questions (FAQs) on the treatment of anthrax disease caused by a wide-area release of Bacillus anthracis spores as an act bioterrorism. These FAQs are intended to provide the public health and medical community, as well as others, with guidance and communications to support the response and long-term recovery from an anthrax event.

  17. ISSUE 55 JULY 2008 Genes and disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 55 JULY 2008 FUNDING Genes and disease In this issue... FUNDING AND UPDATES 2­5 Project building, in Kenya, South Africa, Uganda and elsewhere in Africa (see page 5). The largest ever study. The Institute will devote a large part of its high-throughput genotyping pipeline, headed by Dr Panos Deloukas

  18. DISEASES OF AQUATIC ORGANISMS Dis Aquat Org

    E-Print Network [OSTI]

    Harvell, Catherine Drew

    and disease in Mexico J. R. Ward1,*, K. L. Rypien1 , J. F. Bruno2 , C. D. Harvell1 , E. Jordán-Dahlgren3 , K Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3300, USA 3

  19. Disease Prediction Models and Operational Readiness

    SciTech Connect (OSTI)

    Corley, Courtney D.; Pullum, Laura L.; Hartley, David M.; Benedum, Corey M.; Noonan, Christine F.; Rabinowitz, Peter M.; Lancaster, Mary J.

    2014-03-19

    INTRODUCTION: The objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information for decision makers to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews. First, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. Second, we considered models involving pathogens of concern as determined by the US National Select Agent Registry (as of June 2011). Methods: We searched dozens of commercial and government databases and harvested Google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, The publication date of search results returned are bound by the dates of coverage of each database and the date in which the search was performed, however all searching was completed by December 31, 2010. This returned 13,767 webpages and 12,152 citations. After de-duplication and removal of extraneous material, a core collection of 6,503 items was established and these publications along with their abstracts are presented in a semantic wiki at http://BioCat.pnnl.gov. Next, PNNL’s IN-SPIRE visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model resulting in the selection of 54 documents that matched the criteria resulting Ten of these documents, However, dealt purely with disease spread models, inactivation of bacteria, or the modeling of human immune system responses to pathogens rather than predicting disease events. As a result, we systematically reviewed 44 papers and the results are presented in this analysis.

  20. Laterality of Motor Symptom Onset, Disease Progression, and Cognition in Parkinson's Disease

    E-Print Network [OSTI]

    Chau, Phuong My

    2010-08-31

    The current study examined whether laterality of initial motor symptom onset (left-sided onset vs. right-sided onset) in Parkinson's disease (PD) would predict the pattern and/or severity of cognitive deficits measured at ...

  1. Disease resistance and performance of blended populations of creepi 

    E-Print Network [OSTI]

    Abernathy, Scott David

    1999-01-01

    Plant diseases are a major problem on creeping bentgrass greens and can significantly decrease putting quality. Blended populations comprised of two or more cultivars within the same species have been utilized to decrease disease development...

  2. Goal-directed Behaviour & Apathy in Parkinson's Disease 

    E-Print Network [OSTI]

    Cox, Simon

    2009-11-26

    Apathy has been described as a highly-prevalent symptom of Parkinson's disease that has a significant effect upon quality of life, even when the motor symptoms of the disease are taken into account.

  3. Characterization of a Drosophila model of Huntington's disease

    E-Print Network [OSTI]

    Lee, Wyan-Ching Mimi

    2006-01-01

    Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

  4. Mycosphaerella species causing leaf disease in South African Eucalyptus plantations

    E-Print Network [OSTI]

    Mycosphaerella species causing leaf disease in South African Eucalyptus plantations Gavin C. HUNTER Eucalyptus plantations provide an important source of hardwood for forestry industries, worldwide. Several species of Mycosphaerella are associated with a destructive Eucalyptus leaf disease known

  5. Women and Heart Disease: Neglected Directions for Future Research

    E-Print Network [OSTI]

    Barrett-Connor, Elizabeth

    2009-01-01

    009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

  6. Endemic models for the spread of infectious diseases with arbitrarily ...

    E-Print Network [OSTI]

    SIAM (#1) 1035 1999 Jan 20 12:53:14

    2000-10-03

    have general length distributions and disease survival functions, the different time ..... In order to describe the duration of the various stages and the related disease ...... Approaches to Problems in Resource Management and Epidemiology, ...

  7. Role of the hedgehog signalling pathway in inflammatory bowel disease 

    E-Print Network [OSTI]

    Lees, Charles William

    2009-01-01

    Introduction. The inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), are common in Western Europe (200-400 cases /100,000) and associated with substantial morbidity, although mortality ...

  8. Measuring human movement for biomechanical applications using markerless motion capture

    E-Print Network [OSTI]

    Sundaresan, Aravind

    in multiple 2D image planes. The three methods are systematically evaluated and results for real data many different fields such as kinesiology, physiotherapy, orthopedic surgery, ergonomics, etc [1 related to musculoskeletal diseases, the development and evaluation of rehabilitative treatments

  9. Nanoscale influences on bioactivity : ultrastructure and nanomechanics of model bioactive hydroxyapatite based biomaterials

    E-Print Network [OSTI]

    Vandiver, Jennifer M. (Jennifer McKeehan)

    2006-01-01

    There is a significant need for improved synthetic materials as orthopedic implants to replace human bone lost and damaged due to disease or injury. Certain ceramics, such as hydroxyapatite (HA), have the special property ...

  10. Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms Molecular mechanisms of aging-related neurodegenerative diseases: emerging views

    E-Print Network [OSTI]

    Breitling, Rainer

    , including Parkinson's disease, polyglutamine expansion diseases and Alzheimer's disease, are associated used to model these diseases and high throughput genetic screens using these models have led-analysis #12;3 Introduction Several age-related neurodegenerative diseases, including Parkinson's disease

  11. (See reverse side) Information about Meningococcal Disease and Vaccination

    E-Print Network [OSTI]

    Dennett, Daniel

    is infected and is coughing or sneezing. Who is at most risk for getting meningococcal disease? High

  12. Exploring Disease Transmission On Networks with Winfried Just

    E-Print Network [OSTI]

    Just, Winfried

    the relevant contact network, depends on the particular disease. Think of the flu vs. a computer virus vs of disease transmission Infectious diseases are caused by pathogens (such as viruses, bacteria, fungi identical. Such models can be embodied in computer code as agent-based models. Winfried Just and Ying Xin

  13. Disease transmission by cannibalism: rare event or common occurrence?

    E-Print Network [OSTI]

    Antonovics, Janis

    Disease transmission by cannibalism: rare event or common occurrence? Volker H. W. Rudolf Cannibalism has been documented as a possible disease transmission route in several species, including humans. However, the dynamics resulting from this type of disease transmission are not well understood. Using

  14. Neurobiology of Disease Parkin Directly Modulates 26S Proteasome Activity

    E-Print Network [OSTI]

    Lübbert, Hermann

    . Introduction Parkinson's disease (PD) is a major neurodegenerative disease characterized by the degenerationNeurobiology of Disease Parkin Directly Modulates 26S Proteasome Activity Ji Won Um,1 Eunju Im,1-University Bochum, D-44780 Bochum, Germany, and 4Biofrontera Bioscience GmbH, D-51377 Leverkusen, Germany Parkinson

  15. Neuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response

    E-Print Network [OSTI]

    Sulzer, David

    in a wide range of toxin-based, inflammatory and genetic Parkinson's disease animal models. KeywordsNeuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response or a Step neuroin- flammatory processes are exacerbated in Parkinson's disease, including glial- mediated reactions

  16. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases

    E-Print Network [OSTI]

    Bellugi, Ursula

    such as Parkinson's disease and amyotrophic lateral sclerosis where patients' cells have been successfully repro the end-stage of the disease. Mouse models provide a means to mimic human genetic forms of diseases. Owingto tech- nical challenges, species differences and genetic background, even neurologic

  17. Emerging infectious diseases of plants: pathogen pollution, climate change

    E-Print Network [OSTI]

    Schweik, Charles M.

    Emerging infectious diseases of plants: pathogen pollution, climate change and agrotechnology, Boston, MA 02115, USA Emerging infectious diseases (EIDs) pose threats to conservation and public health a series of emerging plant diseases. We include EIDs of cultivated and wild plants, some of which

  18. Understanding Equine Strangles: Signs of Disease, Management and Prevention1

    E-Print Network [OSTI]

    Watson, Craig A.

    in 1251. The infection is highly contagious in horse populations and can recur on farms with previous outbreaks of the disease. It is one of the most commonly diagnosed contagious diseases of the horse signs of infection. Complications of Disease Fortunately, although strangles is highly contagious

  19. A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN

    E-Print Network [OSTI]

    A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN BY R. R. RUCKER, W. J. WHIPPLE, J. R A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN By R. R. Rucker, W. J. Whipple, J. R. Parvin and C. A #12;A CONTAGIOUS DISEASE OF SALMON, POSSIBLY OF VIRUS ORIGIN By R. R. Rucker,! Fishery Research

  20. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  1. Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn’s Disease 

    E-Print Network [OSTI]

    Phillips, Anne Mairead

    2011-07-05

    The inflammatory bowel diseases (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract. Their aetiology is not fully understood but is thought ...

  2. An investigation of the genetic determinants of succeptibility and disease behavoir in early onset Inflammatory Bowel Disease in Scottish children. 

    E-Print Network [OSTI]

    Russell, Richard K

    2008-01-01

    A series of investigations examining the importance of genetic factors in the development of the inflammatory bowel diseases (IBD) namely Crohn’s disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC) has ...

  3. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01

    in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang •

  4. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01

    predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

  5. Understanding diseases at a molecular level

    SciTech Connect (OSTI)

    Rosev, Tatjana K [Los Alamos National Laboratory

    2008-01-01

    A group of scientists at Los Alamos National Laboratory in 2008 successfully pioneered a microscope able to track protein-sized, hard to see particles in three dimensions. The 3D Tracking Microscope, designed and developed by James H. Werner, Guillaume A. Lessard, Nathan Wells and Peter M. Goodwin of LANL's Center for Integrated Nanotechnologies, won a 2008 R&D 100 award. The team's invention is a unique confocal 3D tracking microscope capable of following the motion of nanometer-sized objects, such as individual molecules, quantum dots, organic fluorophores and single green fluorescent proteins as they zoom through three-dimensional space at rates faster than many intracellular transport processes. The 3D tracking microscope can follow the transport of nanometer-sized particles at micrometer per second rates. This enables researchers to follow individual protein, ribonucleic acid (RNA), or deoxyribonucleic acid (DNA) motion throughout the full three-dimensional volume of a cell to discover the path a particular biomolecule takes, the method it employs to get there and the specific proteins it may be interacting with along the way. In addition to applications in molecular spectroscopy and materials research, the 3D tracking microscope is a powerful tool primarily in the fields of cellular biology and biomedical research, Werner said. 'The 3D tracking microscope will advance our understanding of the molecular basis and kinetics of many diseases, such as cancer, diabetes, or muscular dystrophy,' he said. 'We anticipate the microscope will become a valuable weapon in the arsenal of biomedical researchers who are fighting to find cures for cancer, heart disease and other protein or DNA-based diseases.'

  6. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  7. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's pneumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  8. Chronic Beryllium Disease Prevention Program Report

    SciTech Connect (OSTI)

    Lee, S

    2012-03-29

    This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

  9. Automated diagnostic kiosk for diagnosing diseases

    DOE Patents [OSTI]

    Regan, John Frederick; Birch, James Michael

    2014-02-11

    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  10. Optical detection dental disease using polarized light

    DOE Patents [OSTI]

    Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Fried, Daniel (San Francisco, CA)

    2003-01-01

    A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.

  11. Maternal Supplement Use During Pregnancy

    E-Print Network [OSTI]

    Bratton, Mallory Michelle

    2012-05-31

    Background: There is little consensus regarding the need for vitamin and mineral supplementation during pregnancy. The composition and use of supplements among pregnant women varies greatly. Toxicity or inadequacy of nutrients could have health...

  12. Media representation of maternal neonaticide 

    E-Print Network [OSTI]

    Lewis, Jocelyn Renee

    2008-10-10

    The present research conducted a rich discourse analysis of an episode of the fictional television crime drama, Law & Order: Special Victims Unit, as well as a content analysis of local and national news transcripts focusing ...

  13. PERIORAL BIOMECHANICS, KINEMATICS, AND ELECTROPHYSIOLOGY IN PARKINSON'S DISEASE

    E-Print Network [OSTI]

    Chu, Shin Ying

    2010-11-21

    This investigation quantitatively characterized the orofacial biomechanics, labial kinematics, and associated electromyography (EMG) patterns in individuals with Parkinson's disease (PD) as a function of anti-PD medication ...

  14. Structure of the Newcastle disease virus hemagglutinin-neuraminidase...

    Office of Scientific and Technical Information (OSTI)

    of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk Citation Details In-Document Search Title: Structure of the Newcastle...

  15. Proteins' Amazing Origami Powers: Insight for Potential Disease...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Senior Writer, Office of Science What are the key facts? Better knowledge of protein folding could in turn provide more insight into the diseases associated with malformed...

  16. Genomics of emerging infectious disease: A PLoS collection.

    E-Print Network [OSTI]

    Eisen, Jonathan A; MacCallum, Catriona J

    2009-01-01

    Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

  17. Psoriasis disease severity affects patient satisfaction with treatment

    E-Print Network [OSTI]

    Korman, Neil J; Zhao, Yang; Lu, Jackie; Tran, Mary Helen

    2015-01-01

    among patients with psoriasis and psoriatic arthritis in thefindings from the National Psoriasis Foundation surveys,J. Mechanism of disease: psoriasis. N Engl J Med. 2009;361(

  18. Recombinant herpes simplex virus useful for treating neoplastic disease

    DOE Patents [OSTI]

    Whitley, Richard J.; Roizman, Bernard

    2010-06-29

    Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.

  19. AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS...

    Office of Scientific and Technical Information (OSTI)

    Converting energy to medical progress nuclear medicine NONE 62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS; NUCLEAR MEDICINE; PATIENTS; RADIATION...

  20. Bacteria Associated With Colitis and Inflammatory Bowel Disease

    E-Print Network [OSTI]

    Ye, Jingxiao

    2009-01-01

    bowel diseases: antibiotics, probiotics, and prebiotics."clinical trial of probiotics (Lactobacillus johnsonii, LA1)Besides antibiotics, probiotics might also be a potential

  1. Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model

    E-Print Network [OSTI]

    Treusch, Sebastian

    2011-01-01

    Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

  2. Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?

    E-Print Network [OSTI]

    Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

    2011-01-01

    case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

  3. Fish oil can help reduce deaths from heart disease,

    E-Print Network [OSTI]

    Shen, Jun

    Fish oil can help reduce deaths from heart disease, according to new evidence reports announced- ute to heart disease. The review also found other evidence indicating that fish oil can help lower in knowledge." Continued, page 2... Evidence Reports Confirm Benefits of Fish Oil Elizabeth Yetley, PhD Joins

  4. Harnessing plasticity to understand learning and treat disease

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Harnessing plasticity to understand learning and treat disease Michael P. Kilgard The University, USA A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies sug- gest that cortical map plasticity is typically a transient phase that improves

  5. Epidemiology / pidmiologie Climate change and plant diseases in Ontario

    E-Print Network [OSTI]

    Boland, Greg J.

    Epidemiology / Épidémiologie Climate change and plant diseases in Ontario G.J. Boland, M.S. Melzer in Ontario will significantly affect the occurrence of plant diseases in agriculture and forestry management plans. Adaptations in agriculture and forestry have been occurring in Ontario for over 100 years

  6. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  7. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  8. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease

    E-Print Network [OSTI]

    Sulzer, David

    State Psychiatric Institute, New York City, NY 10032, USA Parkinson's disease arises from geneticMultiple hit hypotheses for dopamine neuron loss in Parkinson's disease David Sulzer Departments features. Although many genetic mutations have been suggested as causes or risk factors for Parkinson

  9. Ash dieback disease www.forestry.gov.uk/planthealth

    E-Print Network [OSTI]

    Ash dieback disease www.forestry.gov.uk/planthealth Pest Alert Distribution In Britain, most of the outbreaks of ash dieback disease in the natural environment are confined to East Anglia and Kent, although a small number of outlying cases have been confirmed in northeast England and Scotland. Common ash

  10. Chronic Beryllium Disease Prevention Environment, Safety, Health, and Quality Division

    E-Print Network [OSTI]

    Wechsler, Risa H.

    Chronic Beryllium Disease Prevention Program Environment, Safety, Health, and Quality Division SLAC-I-730-0A09M-001-R003 24 September 2013 #12;Publication Data This document was developed by the Beryllium program and published by ESHQ Publishing. Document Title: Chronic Beryllium Disease Prevention Program

  11. Economic Consideration of Mitigation of Foreign Animal Disease Introduction *

    E-Print Network [OSTI]

    McCarl, Bruce A.

    Economic Consideration of Mitigation of Foreign Animal Disease Introduction * Levan Elbakidze, Bruce A. McCarl Department of Agricultural Economics National Center for Foreign Animal and Zoonotic Disease Defense (FAZDD), Texas A&M University, College Station TX, USA The economic implications

  12. Motor signs during the course of Alzheimer disease

    E-Print Network [OSTI]

    to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits

  13. Research Fund for the Prevention and Treatment of Kidney Disease

    E-Print Network [OSTI]

    Weber, David J.

    and economic costs associated with these diseases. UMMC accommodates one million patient visits a year With a reputation for innovation and technical and surgical excellence, the UMSOM Division of Transplantation is one global cost for treatment of kidney disease in terms of dialysis and transplantation over the next decade

  14. Asbestos-related pulmonary disease in boilermakers

    SciTech Connect (OSTI)

    Demers, R.Y.; Neale, A.V.; Robins, T.; Herman, S.C. )

    1990-01-01

    Boilermakers are skilled building tradesmen who construct, repair, and dismantle boilers. The present study reports on the evaluation of members of a Michigan boilermaker's union for the presence of signs and symptoms of chronic pulmonary disease. Study variables included standardized evaluations of chest x-ray findings, pulmonary function testing, physical examination, and respiratory symptoms. An overall participation rate of 69% was achieved. A non-participant survey identified no significant differences between participants and non-participants in dyspnea, cough, age, or smoking history. Among participants with greater than 20 years experience in the trade, the mean FVC was 91% of predicted; the FEV1 was 86% of predicted; 25% showed at least a 1/0 profusion of interstitial markings on chest x-ray; 30% had bilateral pleural abnormalities; and 52% had audible inspiratory rales on physical examination. Forced vital capacity and forced expiratory volume at one second both decreased with years in the trade. Chest x-ray findings of interstitial fibrosis and pleural plaques were related to ten or more years in the trade, as were respiratory symptoms of pulmonary rales, wheeze, and dyspnea.

  15. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK

    E-Print Network [OSTI]

    Sulzer, David

    and 2 Department of Neurology, Center for Parkinson's Disease and Other Movement Disorders, Columbia Disease, polyglutamine disease (CAG repeat), and Parkinson disease (10). Ã To whom correspondence shouldAutophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and m

  16. Commercial Pecans: Controlling Rosette, Diseases and Zinc Deficiency 

    E-Print Network [OSTI]

    Lee, Thomas A.; Krausz, Joseph P.

    2006-04-13

    to be healthy and vigor- ous and for nut quality and yield to be satisfactory, producers must establish sound disease-management programs. Producers can pre- vent losses from diseases and insuff_i cient zinc by implementing ef_fective grove management... fall. Although the foliage is mature and no longer susceptible to the scab fun- gus, the shucks surrounding the nuts are immature and vulnerable to late-season infections. Factors inf_l uencing disease development As you develop a spray program...

  17. PrPSc complexity in different forms of Creutzfeldt-Jakob disease identified using biochemical approaches 

    E-Print Network [OSTI]

    Choi, Young Pyo

    2010-01-01

    Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative diseases affecting humans and animal species. Prion diseases are characterized by the conversion of the host encoded ...

  18. HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF ENERGY CONSERVATION IN RESIDENTIAL BUILDINGS

    E-Print Network [OSTI]

    Budnitz, R.J.

    2011-01-01

    Buildings H M N DISEASE FROM RADON EXPOSURES: U A THE IMPACTVent 78-6 HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OFof conservation measures on radon levels, and the disease

  19. Tackling Africa's chronic disease burden: from the local to the global

    E-Print Network [OSTI]

    de-Graft Aikins, Ama; Unwin, Nigel; Agyemang, Charles; Allotey, Pascale; Campbell, Catherine; Arhinful, Daniel

    2010-04-19

    Abstract Africa faces a double burden of infectious and chronic diseases. While infectious diseases still account for at least 69% of deaths on the continent, age specific mortality rates from chronic diseases as a whole are actually higher in sub...

  20. Speaker for Nov. 1 Lecture to Discuss Deadliest Viral Diseases...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    These studies have led her from the U.S. Centers for Disease Control and Prevention to Lyon, France, where she was instrumental in designing, constructing and making operational a...

  1. Interpreting noncoding genetic variation in complex traits and human disease

    E-Print Network [OSTI]

    Kellis, Manolis

    Association studies provide genome-wide information about the genetic basis of complex disease, but medical research has focused primarily on protein-coding variants, owing to the difficulty of interpreting noncoding ...

  2. Striatal origin of the pathologic beta oscillations in Parkinson's disease

    E-Print Network [OSTI]

    Boyden, Edward Stuart

    Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...

  3. Superspreading and the impact of individual variation on disease emergence

    E-Print Network [OSTI]

    Getz, Wayne M.

    1 Superspreading and the impact of individual variation on disease emergence Supplementary.................................................................................................................................. 4 1.1 Factors contributing to variation in infectiousness 2.2.2 Parameter estimation from mean and proportion of zeros .................................... 8

  4. Enhancing synaptogenesis in diseases characterized by deficiencies in brain synapses

    E-Print Network [OSTI]

    Wurtman, Richard Jay

    The loss of hippocampal and cortical synapses, resulting from impaired synaptogenesis, accelerated synaptic degeneration, or both, is one of the earliest neuropathologic findings in Alzheimer’s Disease and is the finding ...

  5. Introduction Multiple sclerosis (MS) is an inflammatory disease of the

    E-Print Network [OSTI]

    Strominger, Jack L.

    Introduction Multiple sclerosis (MS) is an inflammatory disease of the CNS affecting 0 the frequency of relapses by 30% in relapsing-remitting multiple sclerosis (MS) patients. In the present study

  6. Computational and experimental studies of collagen and related diseases

    E-Print Network [OSTI]

    Yang, Chen, M. Eng. Massachusetts Institute of Technology

    2005-01-01

    Collagen is the most abundant proteins in mammals, and collagen degradation is a process that may be associated with many diseases. In this research we use collagen-like peptides that model both cleavage and noncleavage ...

  7. A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE 

    E-Print Network [OSTI]

    Newton, Billy W.

    2010-01-16

    Alcoholic steatosis (AS) is the initial pathology associated with early stage alcoholic liver disease and is characterized by the accumulation of fat in the liver. AS is considered clinically benign as it is reversible, ...

  8. Peptide immunotherapy in models of allergic airways disease 

    E-Print Network [OSTI]

    MacKenzie, Karen Joan

    2011-11-25

    Allergen-reactive CD4+ T cells are implicated in the pathogenesis of allergic disease. Peptide immunotherapy (PIT) involves therapeutic administration of short immunodominant peptides from within the protein allergen to ...

  9. Ecologic niche modeling and spatial patterns of disease transmission

    E-Print Network [OSTI]

    Peterson, A. Townsend

    2006-12-01

    Ecologic niche modeling (ENM) is a growing field with many potential applications to questions regarding the geography and ecology of disease transmission. Specifically, ENM has the potential to inform investigations concerned ...

  10. Biological studies and characterization of the High Plains Disease pathogen 

    E-Print Network [OSTI]

    Mirabile, Joanna

    2001-01-01

    High Plains Disease (HPD), which is a recently recognized affliction causing up to 80% yield losses in corn and wheat, has been suspected to be of viral origin, however no clear evidence existed to validate this claim. ...

  11. Parenting styles, peer influences, and adolescent cardiovascular disease risk factors 

    E-Print Network [OSTI]

    Tramm, Amy Bishop

    2000-01-01

    Parenting and friendship styles were examined as indicators for obesity and risk of cardiovascular disease in 54 Texas adolescents. This study investigated the relationship between parental and peer influences on obesity ...

  12. Cognitive change in motor neurone disease : evidence of orbitofrontal dysfunction 

    E-Print Network [OSTI]

    McNeill, Ewan

    2006-01-01

    This study examines the presence of cognitive changes in amyotrophic lateral sclerosis (ALS), a subtype of motor neurone disease. Past research has shown executive dysfunction in patients with ALS and frontotemporal ...

  13. Marek’s disease virus pathogenesis and latency 

    E-Print Network [OSTI]

    Hunter, Gillian

    2012-11-30

    Marek’s Disease virus (MDV) is a highly contagious, widespread and persistent neoplastic ?-herpesvirus causing extensive lymphoblastic tumours in chickens. The virus is shed in feather dust and spread through inhalation. ...

  14. Nature of language impairment in motor neurone disease 

    E-Print Network [OSTI]

    Rewaj, Phillipa Jane

    2014-07-01

    Background: Language impairment associated with Motor Neurone Disease (MND) has been documented since the late 19th century, yet little is understood about the pervasiveness or nature of these deficits. The common clinical ...

  15. GUIDE FOR IDENTIFICATION OF IMPORTANT DISEASES IN STRAWBERRY IN CALIFORNIA

    E-Print Network [OSTI]

    Ullrich, Paul

    GUIDE FOR IDENTIFICATION OF IMPORTANT DISEASES IN STRAWBERRY IN CALIFORNIA Anthracnose Angular Leaf on the underside of the leaf is one of the most recognizable signs of bacterial infection on strawberry leaves

  16. Disease marketing and patient coping : a research study

    E-Print Network [OSTI]

    Lau, Hew Mun

    2012-01-01

    BACKGROUND: There is a high prevalence of disease marketing actions in the United States that are targeted towards patients with chronic illness. However, no study has assessed the direct effects of these marketing actions ...

  17. Transforming South–South Technical Support to Fight Noncommunicable Diseases

    E-Print Network [OSTI]

    Shakow, Aaron D.A.

    At the UN High-Level Meeting on non-communicable diseases (NCD) in September 2011, each member state was challenged to create a multisectoral national policy and plan for the prevention and control of non-communicable ...

  18. Polyamine pathway contributes to the pathogenesis of Parkinson disease

    E-Print Network [OSTI]

    Lewandowski, Nicole M.

    The full complement of molecular pathways contributing to the pathogenesis of Parkinson disease (PD) remains unknown. Here we address this issue by taking a broad approach, beginning by using functional MRI to identify ...

  19. Interactive Whole-Heart Segmentation in Congenital Heart Disease

    E-Print Network [OSTI]

    Pace, Danielle Frances

    We present an interactive algorithm to segment the heart chambers and epicardial surfaces, including the great vessel walls, in pediatric cardiac MRI of congenital heart disease. Accurate whole-heart ...

  20. Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease

    E-Print Network [OSTI]

    Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease Christian Habeck January 2008 Available online 14 February 2008 We performed univariate and multivariate discriminant univariate and multivariate analyses produced markers with high classification accuracy in the derivation

  1. Food, Poverty and Epidemic Disease, Edinburgh: 1840-1850 

    E-Print Network [OSTI]

    MacGillivray, Neil

    2004-01-01

    The thesis first examines the link between nutrition and disease, focusing on the poor of Edinburgh during the 184Os, a time of economic depression and food shortage. The development of nutritional science and the level ...

  2. Host nutrition and infectious disease: an ecological view

    E-Print Network [OSTI]

    Smith, Val H.; Jones II, Tyrees P.; Smith, Marilyn S.

    2005-06-01

    Nutrition is typically discussed in terms of maintaining a proper diet and avoiding nutrient deficiency diseases. However, nutrition can also be viewed from an ecological standpoint: mammalian hosts and their pathogens ...

  3. Strategic Global Alliances in Vaccine Development and Disease Control

    E-Print Network [OSTI]

    Schnaufer, Achim

    Strategic Global Alliances in Vaccine Development and Disease Control Dr Sadhana Sharma BBSRC · UK veterinary vaccinology network · Global veterinary vaccinology alliance #12;3 COORDINATION public engagement on bioscience What we do: #12;"Global Strategic Alliances for the Coordination

  4. Neuroimaging of Discourse Processing in Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Wang, Clarice

    2011-12-31

    Detection of very early stages of Alzheimer's Disease (AD) has been an area of difficulty for researchers due to confounds with age. Prose recall has been suggested as a diagnostically sensitive test of episodic memory declines in AD; however...

  5. Timing of testing and treatment for asymptomatic diseases

    SciTech Connect (OSTI)

    K?rk?zlar, Eser; Faissol, Daniel M.; Griffin, Paul M.; Swann, Julie L.

    2010-07-01

    Many papers in the medical literature analyze the cost-effectiveness of screening for diseases by comparing a limited number of a priori testing policies under estimated problem parameters. However, this may be insufficient to determine the best timing of the tests or incorporate changes over time. In this paper, we develop and solve a Markov Decision Process (MDP) model for a simple class of asymptomatic diseases in order to provide the building blocks for analysis of a more general class of diseases. We provide a computationally efficient method for determining a cost-effective dynamic intervention strategy that takes into account (i) the results of the previous test for each individual and (ii) the change in the individual’s behavior based on awareness of the disease. We demonstrate the usefulness of the approach by applying the results to screening decisions for Hepatitis C (HCV) using medical data, and compare our findings to current HCV screening recommendations.

  6. Medicating race : heart disease and durable preoccupations with difference

    E-Print Network [OSTI]

    Pollock, Anne, 1975-

    2007-01-01

    This dissertation is an examination of intersections of race, pharmaceuticals, and heart disease over the course of the 20th century and today. Each of these parts has had a dynamic history, and when they are invoked ...

  7. Mechanisms of disease pathogenesis in Spinal Muscular Atrophy 

    E-Print Network [OSTI]

    Mutsaers, Chantal

    2014-06-28

    Low levels of survival motor neuron (SMN) protein cause the autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA), through mechanisms that are poorly defined. SMN protein is ubiquitously expressed, ...

  8. Field Diseases of the Sweet Potato in Texas. 

    E-Print Network [OSTI]

    Taubenhaus, J. J. (Jacob Joseph)

    1919-01-01

    the diseases of the sweet potato. Instead, the corrosive sub: mate treatment should be resorted to because of its efficiency as a fun$ cide arid because of the stimulating effect which it exerts on the resul ing sprouts. After carefully selecting the seed... sweet potatoes for shape (Fig. 1) and discarding all the "shoe strings" (Fig. 2), they should be disinfected with corrosive sublimate solution. This treatment aims at killing the spores of the various disease producing organisms which adhere...

  9. Engineering disease resistance with pectate lyase-like genes

    DOE Patents [OSTI]

    Vogel, John; Somerville, Shauna

    2005-03-08

    A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

  10. Characterization of Resistance to Black Spot Disease of Rosa Spp. 

    E-Print Network [OSTI]

    Dong, Qianni

    2014-12-01

    Young-Ki Jo Joshua Yuan Head of Department, Daniel R. Lineberger December 2014 Choose an item. Choose an item. Major Subject: Horticulture Copyright.... These trials typically last 2-3 years to ensure sufficient disease pressure to properly assess the resistance of the plants (Carlson-Nilsson, 2000; Noack, 2003; Shupert, 2005). Lab based detached leaf 4 assay (DLA) is a tool for observing disease...

  11. The inflammatory response in transgastric surgery: gastric content leak leads to localized inflammatory response and higher adhesive disease

    E-Print Network [OSTI]

    2010-01-01

    response and higher adhesive disease Sonia L. Ramamoorthy Æin?ammatory markers, adhesive disease, and morbidity.cantly higher rate of adhesive disease in the SG compared

  12. Thoracic irradiation in Hodgkin's disease: Disease control and long-term complications

    SciTech Connect (OSTI)

    Tarbell, N.J.; Thompson, L.; Mauch, P. (Harvard Medical School, Boston, MA (USA))

    1990-02-01

    A total of 590 patients with Stage IA-IIIB Hodgkin's disease received mantle irradiation at the Joint Center for Radiation Therapy between April 1969 and December 1984 as part of their initial treatment. Recurrence patterns as well as pulmonary, cardiac and thyroid complications were analyzed. Pulmonary recurrence was more frequently seen in patients with large mediastinal adenopathy (LMA); 11% of patients with LMA recurred in the lung in contrast to 3.1% with small or no mediastinal disease, p = 0.003. Hilar involvement, when corrected for size of mediastinal involvement, was not predictive of lung relapse. Patients with LMA also had a high rate of nodal relapse above the diaphragm (40%) following radiation therapy (RT) alone as compared to similarly treated patients with small or no mediastinal adenopathy (6.5%), p less than 0.0001. This risk of nodal recurrence was greatly reduced (4.7%) for LMA patients receiving combined radiation therapy and chemotherapy (CMT), p less than 0.0001. Sixty-seven patients (11%) with hilar or large mediastinal involvement received prophylactic, low dose, whole lung irradiation. No decrease in the frequency of lung recurrence was seen with the use of whole lung irradiation. Radiation pneumonitis was seen in 3% of patients receiving radiation therapy alone. In contrast, the use of whole lung irradiation was associated with a 15% risk of pneumonitis, p = 0.006. The risk of pneumonitis was also significantly increased with the use of chemotherapy (11%), p = 0.0001. Cardiac complications were uncommon with pericarditis being the most common complication (2.2%). Thyroid dysfunction was seen in 25% of patients and appeared to be age-related. These data suggest that the long-term complications of mantle irradiation are uncommon with the use of modern radiotherapeutic techniques.

  13. Textile-Based Sensor Development for the Continuous Monitoring of Proper Orthopedic Cast Fit

    E-Print Network [OSTI]

    Umsted, Carson Andrew

    2013-01-01

    Evaluation .. 13 Chapter 3: Sensorforce sensor worked very well in the evaluation phase andthe sensor performance was good in initial evaluation, to be

  14. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01

    tantalum: changes with oxide layer and hydroxyapatite at theTantalum - Changes with Oxide Layer and Hydroxyapatite atand pH), the solid oxide layer can be either compact, or

  15. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01

    applications. Solar Energy Materials and Solar Cells, 2006.arrays: Fabrication, material properties, and solar energysolar energy, water splitting, and the biomedical materials

  16. SmartCast - Novel Textile Sensors for Embedded Pressure Sensing of Orthopedic Casts

    E-Print Network [OSTI]

    Danilovic, Andrew

    2013-01-01

    set_sleep_mode(SLEEP_MODE_PWR_DOWN); //enter Power-down Mode4 #define SEL2_PB0 8 #define SEL1_PD7 7 #define PWR_CTRL_PINPD5 #define PWR_CTRL_SD_CARD 6 //SmartCast bitFields for

  17. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01

    Properties of TiO2 Nanotubes. Solid State Phenomena, 2010.and A. Bandyopadhyay, TiO2 nanotubes on Ti: Influence of2075. Macak, J.M. , et al. , TiO2 nanotubes: Self-organized

  18. A Novel Wireless Health Orthopedic System Integrating Motion and Acoustic Emission Monitoring

    E-Print Network [OSTI]

    Paul, Manda

    2013-01-01

    mems/gyro/mpu9150.html›. [17] Nine-Axis Sensor Fusion UsingBoard Sensor: MPU-9150 o Triple-axis MEMS gyroscope,Sensor; 16-bit ADC; Digital Motion Processor; 9 axis MEMS;

  19. Evaluation of Biomimetic and Alloy-based Materials for Orthopedic Applications 

    E-Print Network [OSTI]

    Guiza-Arguello, Viviana R.

    2013-07-17

    The basic principle of tissue engineering is the combination of appropriate cells with biomaterials under conditions that promote and lead to tissue formation. A tissue engineering scaffold is a material that supports cells for their growth...

  20. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01

    dental applications, including bioactive glasses, ceramics, and composites [10]. Resorbable biomaterials (

  1. Development of Controlled Matrix Heterogeneity on a Triphasic Scaffold for Orthopedic Interface Tissue Engineering

    E-Print Network [OSTI]

    Lu, Helen H.

    reconstruction because of the high incidence of donor site morbidity associated with bone-patellar 1 Biomaterials Department of Orthopaedic Surgery, Columbia University, New York, New York. 4 College of Dental Medicine

  2. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01

    nanostructured cubic zirconia. arXiv.org, 13. Biggs, M.J. ,et al. , Bioactivity of zirconia nanotube arrays fabricatedcrosslinked UHMWPE and zirconia implants in knee simulation.

  3. Quantitative determination of proximal radial and ulnar growth rates in foals using orthopedic markers 

    E-Print Network [OSTI]

    Smith, Barbara Lynn

    1988-01-01

    and ulna. Horse 6 both limbs 29 10 Cumulative growth of proximal radius and ulna. All horses all limbs 31 FIGURE page Cumulative growth of proximal radius and ulna. All horses left limbs 34 12 Cumulative growth of proximal radius and ulna. All horses... 27 Cumulati ve growth of radius and ulna at epiphyseal and meta- physeal levels. All horses left limbs 70 28 Cumulative growth between radius and ulna at epiphyseal and meta- physeal levels. All horses right limbs 72 29 Immediate postop...

  4. Improved performance of ultra-high molecular weight polyethylene for orthopedic applications 

    E-Print Network [OSTI]

    Plumlee, Kevin Grant

    2009-05-15

    taken in a JOEL-6400 scanning electron microscope (SEM), and were prepared using a ruthenium vapor coating method [28], then lightly sputter-coated with gold-palladium. Sections of impact samples were cut with razor blades, and then imaged in both.... Samples were prepared for imaging first with a ruthenium vapor coating 29 technique [28], then with a light sputter coating of gold-palladium. The ruthenium vapor coating creates a more even coating on highly mottled surfaces than sputter coating would...

  5. Holdover inoculum of Pseudomonas syringae pv. alisalensis from broccoli raab causes disease in subsequent plantings

    E-Print Network [OSTI]

    Cintas, N A; Koike, S T; Bunch, R A; Bull, C T

    2006-01-01

    alisalensis from Broccoli Raab Causes Disease in Subsequentalisalensis from broccoli raab causes disease in subsequentsyringae pv. maculicola causes bacterial spot on many

  6. Rheumatic Heart Disease and Beta-hemolytic Streptococci in Salvador, Brazil: A Study of Slum Health

    E-Print Network [OSTI]

    Tartof, Sara Yee

    2010-01-01

    rheumatic fever and rheumatic heart disease in Africa. S Afrthe chain that links the heart to the throat? Lancet Infectchildren with rheumatic heart disease. J Thorac Cardiovasc

  7. Is coronary heart disease rising in India? A systematic review based on ECG defined coronary heart disease 

    E-Print Network [OSTI]

    Ahmad, N; Bhopal, Raj

    2005-01-01

    The aim of this study was to investigate whether coronary heart disease (CHD) is rising in India and assess the quality of the evidence. Thirty one studies were reviewed. The sample sizes of the studies varied from ...

  8. New insights into the natural history of thrombo-embolic disease provided by imaging and disease quantification 

    E-Print Network [OSTI]

    Murchison, John Tallach

    2013-07-06

    Venous thromboembolism (VTE) is a common disease with a myriad of presentation. It is often difficult to diagnosis with symptoms which are shared with many other disorders. Because of the overlap in symptomatology with ...

  9. Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases

    E-Print Network [OSTI]

    Jackson, Walker S.

    In man, mutations in different regions of the prion protein (PrP) are associated with infectious neurodegenerative diseases that have remarkably different clinical signs and neuropathological lesions. To explore the roots ...

  10. Integrative Analysis of Common Neurodegenerative Diseases Using Gene Association, Interaction Networks and mRNA Expression Data

    E-Print Network [OSTI]

    Koyuturk, Mehmet

    , Inc., Cleveland OH. * Corresponding author Abstract Alzheimer's and Parkinson's diseases (AD and PD Alzheimer's disease (AD) and Parkinson's disease (PD) are caused by progressive degeneration and/or deathIntegrative Analysis of Common Neurodegenerative Diseases Using Gene Association, Interaction

  11. Airborne spread of foot-and-mouth disease - model intercomparison

    SciTech Connect (OSTI)

    Gloster, J; Jones, A; Redington, A; Burgin, L; Sorensen, J H; Turner, R; Dillon, M; Hullinger, P; Simpson, M; Astrup, P; Garner, G; Stewart, P; D'Amours, R; Sellers, R; Paton, D

    2008-09-04

    Foot-and-mouth disease is a highly infectious vesicular disease of cloven-hoofed animals caused by foot-and-mouth disease virus. It spreads by direct contact between animals, by animal products (milk, meat and semen), by mechanical transfer on people or fomites and by the airborne route - with the relative importance of each mechanism depending on the particular outbreak characteristics. Over the years a number of workers have developed or adapted atmospheric dispersion models to assess the risk of foot-and-mouth disease virus spread through the air. Six of these models were compared at a workshop hosted by the Institute for Animal Health/Met Office during 2008. A number of key issues emerged from the workshop and subsequent modelling work: (1) in general all of the models predicted similar directions for 'at risk' livestock with much of the remaining differences strongly related to differences in the meteorological data used; (2) determination of an accurate sequence of events is highly important, especially if the meteorological conditions vary substantially during the virus emission period; and (3) differences in assumptions made about virus release, environmental fate, and subsequent infection can substantially modify the size and location of the downwind risk area. Close relationships have now been established between participants, which in the event of an outbreak of disease could be readily activated to supply advice or modelling support.

  12. Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function*

    E-Print Network [OSTI]

    Li, Lian

    Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function by which loss-of-function mutations in DJ-1 lead to Par- kinson's disease. Parkinson's disease (PD)1 of this devastating disease. Recent evidence indi- cates that at least 10 distinct genetic loci, PARK1­PARK10

  13. Available online at www.sciencedirect.com A cellular perspective on conformational disease: the role of

    E-Print Network [OSTI]

    Morimoto, Richard

    of destabilized proteins. Genetic mutations in conformational disease-associated proteins, as well as exposure in the genetic background may account for some of the cell-type specificity observed in disease, even when neurodegenerative diseases, including Alzheimer's Dis- ease (AD), Parkinson's Disease (PD), Amyotrophic Lat- eral

  14. Clues to How Alpha-Synuclein Damages Neurons in Parkinson's Disease

    E-Print Network [OSTI]

    Sulzer, David

    -synuclein; Parkinson's disease a-SYN AS A CAUSE OF PARKINSON'S DISEASE Multiple genetic mutations can cause ParkinsonClues to How Alpha-Synuclein Damages Neurons in Parkinson's Disease David Sulzer, PhD* Departments vesicles. The pathogenic effects of a-syn leading to Parkin- son's disease (PD) appear to result from

  15. Exploring candidate genes for human brain diseases from a brain-specific gene network

    E-Print Network [OSTI]

    Jiang,Tianzi

    identifying multiple candidate genes for genetic human brain diseases from a brain-specific gene network; Candidate genes Many common human brain diseases, such as schizo- phrenia, Alzheimer's disease, Parkinson's disease, depres- sion, etc., have prominent genetic components [1,2]. Most researchers think that large

  16. Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases*

    E-Print Network [OSTI]

    Li, Lian

    Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases* Received an autosomal recessive, early onset familial form of Parkinson disease (PD). However, little is presently known with sporadic PD and AD. Alzheimer disease (AD)2 and Parkinson disease (PD) are the two most common

  17. South Carolina Pest Management Handbook for Field Crops -2015 TOBACCO DISEASE MANAGEMENT

    E-Print Network [OSTI]

    Stuart, Steven J.

    South Carolina Pest Management Handbook for Field Crops - 2015 293 TOBACCO DISEASE MANAGEMENT Bruce and potentially devastating diseases of tobacco can best be managed through a combination of control methods. It is urged that growers identify disease problems in their fields and follow disease management suggestions

  18. Estimating Seasonal Drivers in Childhood Infectious Diseases with Continuous Time Models 

    E-Print Network [OSTI]

    Abbott, George H.

    2010-07-14

    similar results for a relatively unstudied city in childhood infectious disease research, Bangkok, Thailand....

  19. Remote sensing, global warming, and vector-borne disease

    SciTech Connect (OSTI)

    Wood, B.; Beck, L.; Dister, S.; Lobitz, B.

    1997-12-31

    The relationship between climate change and the pattern of vector-borne disease can be viewed at a variety of spatial and temporal scales. At one extreme are changes such as global warming, which are continental in scale and occur over periods of years, decades, or longer. At the opposite extreme are changes associated with severe weather events, which can occur at local and regional scales over periods of days, weeks, or months. Key ecological factors affecting the distribution of vector-borne diseases include temperature, precipitation, and habitat availability, and their impact on vectors, pathogens, reservoirs, and hosts. Global warming can potentially alter these factors, thereby affecting the spatial and temporal patterns of disease.

  20. Using dimension reduction to improve outbreak predictability of multistrain diseases

    E-Print Network [OSTI]

    Leah B. Shaw; Lora Billings; Ira B. Schwartz

    2006-07-12

    Multistrain diseases have multiple distinct coexisting serotypes (strains). For some diseases, such as dengue fever, the serotypes interact by antibody-dependent enhancement (ADE), in which infection with a single serotype is asymptomatic, but contact with a second serotype leads to higher viral load and greater infectivity. We present and analyze a dynamic compartmental model for multiple serotypes exhibiting ADE. Using center manifold techniques, we show how the dynamics rapidly collapses to a lower dimensional system. Using the constructed reduced model, we can explain previously observed synchrony between certain classes of primary and secondary infectives (Schwartz et al., Phys. Rev. E 72: 066201, 2005). Additionally, we show numerically that the center manifold equations apply even to noisy systems. Both deterministic and stochastic versions of the model enable prediction of asymptomatic individuals that are difficult to track during an epidemic. We also show how this technique may be applicable to other multistrain disease models, such as those with cross-immunity.

  1. Investigation of saliva of patients with periodontal disease using NAA

    SciTech Connect (OSTI)

    Zamboni, C. B.; Metairon, S.; Medeiros, I. M. M. A.

    2013-05-06

    In this study the non-stimulated whole saliva of 26 healthy subjects (mean age 33.9 {+-} 11.0 years, range: 26 to 49 years) and 11 patients with periodontal disease (mean age 41.7 {+-} 11.5 years; range 29 to 55 years) was investigated using Neutron Activation Analysis (NAA) technique. The samples were obtained from donors at Sao Paulo city (Brazil). The analyses were performed in the nuclear reactor IEA-R1 (3.5-4.5MW, pool type) at IPEN/CNEN-SP (Brazil). Considerable changes in Ca and S saliva's level were identified in patients with periodontal disease suggesting they can be used as monitors of periodontal diseases.

  2. Complications of treatment of Hodgkin's disease in children

    SciTech Connect (OSTI)

    Donaldson, S.S.; Kaplan, H.S.

    1982-04-01

    An analysis of complications of therapy requires long-term and frequent followup. Reported here is a review of 179 consecutive children with Hodgkin's disease from Stanford University Medical Center who were seen, treated, and followed over a 20-year period. Complications of treatment are related to the extent of disease and the aggressiveness of therapy. Severe complications from radiotherapy are associated with high-dose, extended-field treatment in preadolescent children. Severe chemotherapy-associated complications include immunosuppression, sterility, and secondary oncogenesis. As cure rates are increasingly optimistic among children with Hodgkin's disease, successful treatment with minimal morbidity remains our greatest challenge. Therapy programs require continual refinement utilizing assessment of short- and long-term side effects of treatment.

  3. Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xia, Jing; Rocke, David M.; Perry, George; Ray, Monika

    2014-01-01

    In late-onset Alzheimer’s disease (AD), multiple brain regions are not affected simultaneously. Comparing the gene expression of the affected regions to identify the differences in the biological processes perturbed can lead to greater insight into AD pathogenesis and early characteristics. We identified differentially expressed (DE) genes from single cell microarray data of four AD affected brain regions: entorhinal cortex (EC), hippocampus (HIP), posterior cingulate cortex (PCC), and middle temporal gyrus (MTG). We organized the DE genes in the four brain regions into region-specific gene coexpression networks. Differential neighborhood analyses in the coexpression networks were performed to identify genes with lowmore »topological overlap (TO) of their direct neighbors. The low TO genes were used to characterize the biological differences between two regions. Our analyses show that increased oxidative stress, along with alterations in lipid metabolism in neurons, may be some of the very early events occurring in AD pathology. Cellular defense mechanisms try to intervene but fail, finally resulting in AD pathology as the disease progresses. Furthermore, disease annotation of the low TO genes in two independent protein interaction networks has resulted in association between cancer, diabetes, renal diseases, and cardiovascular diseases.« less

  4. Compositions and Methods for the Treatment of Pierce's Disease

    DOE Patents [OSTI]

    Gupta, Goutam (Santa Fe, NM)

    2008-10-07

    Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

  5. Neurobiology of Disease Cortical Folding Abnormalities in Autism Revealed by

    E-Print Network [OSTI]

    Van Essen, David

    Neurobiology of Disease Cortical Folding Abnormalities in Autism Revealed by Surface-based morphometry across a range of autism spectrum disorders (7.5­18 years of age). We generated sulcal depth maps autism spectrum disorder subgroups: low-functioning autism, high-functioning autism, and Asperger

  6. Disease Risks Associated with Importation of Nonindigenous Marine Animals

    E-Print Network [OSTI]

    at the Nonindigenous Marine Species Plan ning Mt;eting of the National Research Council, Washington, D.C., 7 May 1991 directed to the third-disease and its implications in introductions. This is entirely logical, since infections that may cause stunting (Kalagayan et aI., 1991). Experimental infections with IHHNV have been

  7. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    ) in five University-based AD centers in the United States and European Union. Four outcomes, assessed every index, and death. Using a standardized portion of the Unified PD Rating Scale (administered every 6 disease (AD). Methods: A total of 533 patients with AD at early stages (mean Folstein Mini-Mental State

  8. Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease

    E-Print Network [OSTI]

    Levenson, Robert W.

    Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease Madeleine instructed and spontaneous emotion regulation in patients with frontotemporal lobar degeneration (FTLD, N 32) unwarned without instructions to down-regulate, (b) warned without instructions to down-regulate, and (c

  9. Azasugar inhibitors as pharmacological chaperones for Krabbe disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hill, Chris H.; Viuff, Agnete H.; Spratley, Samantha J.; Salamone, Stéphane; Christensen, Stig H.; Read, Randy J.; Moriarty, Nigel W.; Jensen, Henrik H.; Deane, Janet E.

    2015-03-23

    Krabbe disease is a devastating neurodegenerative disorder characterized by rapid demyelination of nerve fibers. This disease is caused by defects in the lysosomal enzyme ?-galactocerebrosidase (GALC), which hydrolyzes the terminal galactose from glycosphingolipids. These lipids are essential components of eukaryotic cell membranes: substrates of GALC include galactocerebroside, the primary lipid component of myelin, and psychosine, a cytotoxic metabolite. Mutations of GALC that cause misfolding of the protein may be responsive to pharmacological chaperone therapy (PCT), whereby small molecules are used to stabilize these mutant proteins, thus correcting trafficking defects and increasing residual catabolic activity in cells. Here we describe amore »new approach for the synthesis of galacto-configured azasugars and the characterization of their interaction with GALC using biophysical, biochemical and crystallographic methods. We identify that the global stabilization of GALC conferred by azasugar derivatives, measured by fluorescence-based thermal shift assays, is directly related to their binding affinity, measured by enzyme inhibition. X-ray crystal structures of these molecules bound in the GALC active site reveal which residues participate in stabilizing interactions, show how potency is achieved and illustrate the penalties of aza/iminosugar ring distortion. The structure–activity relationships described here identify the key physical properties required of pharmacological chaperones for Krabbe disease and highlight the potential of azasugars as stabilizing agents for future enzyme replacement therapies. This work lays the foundation for new drug-based treatments of Krabbe disease.« less

  10. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    CME Motor signs predict poor outcomes in Alzheimer disease N. Scarmeas, MD; M. Albert, PhD; J--Objective: To examine whether the presence of motor signs has predictive value for important outcomes in Alzheimer months for a total of 3,149 visit-assessments, average 5.9 per patient), the presence of motor signs

  11. Transmission mode and disease thresholds in host communities Janis Antonovics,

    E-Print Network [OSTI]

    Antonovics, Janis

    1 Transmission mode and disease thresholds in host communities Janis Antonovics, Department of Biology, University of Virginia, VA 22904, USA E-mail: ja8n@virginia.edu Running title Transmission mode transmission have close analogies with thresholds for species persistence when there is competition

  12. Polymorphism in sexual versus non-sexual disease transmission

    E-Print Network [OSTI]

    Antonovics, Janis

    Polymorphism in sexual versus non-sexual disease transmission PETER H. THRALL AND JANIS ANTONOVICS conditions under which a genetic variant with one (e.g. sexual) transmission mode can invade and successfully displace a genetic variant with a different (e.g. non-sexual) transmission mode. Invasion by an STD

  13. GUANYLATE CYCLASE-ACTIVATING PROTEINS AND RETINA DISEASE

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    of the rod cell contains high levels of cGMP (1­10 M) maintaining a number of CNG channels in an open state. Within milliseconds after a light flash, cGMP-gated (CNG) cation channels close and photoreceptor cells hyperpolarize. Open CNG 71 E. Carafoli and M. Brini (eds.), Calcium Signalling and Disease, 71­91. © 2007

  14. Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs

    E-Print Network [OSTI]

    Babu, M. Madan

    31st Jan 2011 Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs M. Madan.....................................................................................................................................2 3.1. IDPs are tightly regulated from transcript synthesis to protein degradation ......................................................................................................................................8 #12;1 Abstract Intrinsically disordered proteins (IDPs) are often enriched in signaling

  15. September/October 2000 New Disease Booklet Web Marketing

    E-Print Network [OSTI]

    Ishida, Yuko

    the Restrictions Strawberry Pollination CSBA Convention Schedule Honey Quality CA Organic Farming New Disease is the APHIS Publication Distribution Center. Strawberry Pollination We don't often look at state or provincial, of Manitoba Agriculture, devised experiments to determine the effect of insect pollination on a strawberry

  16. Bayesian approach to transforming public gene expression repositories into disease

    E-Print Network [OSTI]

    Zhou, Xianghong Jasmine

    expression data and heterogeneous disease annota- tions, allows analyzing both sources of information concepts. This effort requires the effective integration of the two major information sources in the GEO of Southern California, Los Angeles, CA 90089; and c Institute of Genomics and Bioinformatics, National Chung

  17. PUBLICATION 600-080 Fish Health and Disease

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    PUBLICATION 600-080 Fish Health and Disease Striped bass (Morone saxitilis) and hybrid striped bass these fish are commonly raised in high densities under intensive aquaculture situations (e.g., cages, ponds of the viral, bacterial, fungal, and parasitic pathogens, but the fish become increasingly susceptible

  18. Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data

    E-Print Network [OSTI]

    Li, Jing

    Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Shui Huang2 , Jing Li2 to alternation in the functional brain network, i.e., the functional connectivity among different brain regions. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds

  19. Mathematical models and the fight against diseases in Africa

    E-Print Network [OSTI]

    Getz, Wayne M.

    Mathematical models and the fight against diseases in Africa Wayne M.Getz a* ,Eleanor Gouws b theories. While South Africa has many talented scientists trained in quantitative methods, relatively few infrastructural investment is needed to address the health crises in Africa. Prior to the advent of HIV

  20. Diseases of plantation forestry trees in eastern and southern Africa

    E-Print Network [OSTI]

    Diseases of plantation forestry trees in eastern and southern Africa J. Roux a*, G. Meke b , B a Introduction Plantations of non-native trees have been grown in Africa for more than 100 years.1,2 The most especially for construction timber and fuel, while in southern Africa this timber also sustains a thriving

  1. Virus Specificity in Disease Systems: Are Species Redundant?

    E-Print Network [OSTI]

    Flecker, Alex

    Chapter 17 m Virus Specificity in Disease Systems: Are Species Redundant? Alison G. Power about the effects of plant viruses despite their ubiquitous distribution in plants. Several recent studies have stressed the prevalence of viruses in natural plant populations (e.g., Power and Remold 1996

  2. 2006 International Centre for Diarrhoeal Disease Research, Bangladesh

    E-Print Network [OSTI]

    California at Berkeley, University of

    © 2006 International Centre for Diarrhoeal Disease Research, Bangladesh J HEALTH POPUL NUTR 2006, including Inner Mongolia, Thailand, Cambodia, and Bangladesh (2-4). In all these regions, the main source suggests the presence of arsenic in ground- water in India and Bangladesh throughout the region defined

  3. Random Disease on the Square Grid J ozsef Balogh

    E-Print Network [OSTI]

    Balogh, Jozsef

    a disease process. The initial configuration is called contagious or successful if the corresponding) squares in a contagious configuration. The solution of the initial exercise is the following: Fact. [Folklore] G(n) = n. Proof. If we paint the squares of a diagonal black, it will be a contagious

  4. Comparing Online Community Structure of Patients of Chronic Diseases

    E-Print Network [OSTI]

    Maddali, Hanuma Teja; Margolis, Peter

    2015-01-01

    In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.

  5. Prediction and Informative Risk Factor Selection of Bone Diseases

    E-Print Network [OSTI]

    Buffalo, State University of New York

    --Electronic health records (EHRs); risk factor analysis; integrated feature extraction; risk factor selection1 Prediction and Informative Risk Factor Selection of Bone Diseases Hui Li, Xiaoyi Li, Murali and the overwhelming amount of electronic health records (EHRs) shared by healthcare institutions and practitioners, we

  6. A Network-Based Approach to Understanding and Predicting Diseases

    E-Print Network [OSTI]

    Chawla, Nitesh V.

    and emergent behavior over time. Our analysis reveals important insights with implications for modeling increases in cost of health care for the United States. Contributions: The aforementioned issues model to assess disease risk for individuals based on medical history. We evaluate the ability of our

  7. AT A GLANCE....INSECTS AND DISEASE PROBLEMS THAT SHOULD BE CONSIDERED THIS PEST/DISEASE/CULTURE

    E-Print Network [OSTI]

    Goodman, Robert M.

    /DISEASE/CULTURE JULY 8- JULY 15 HARVEST JULY 15- JULY 22 HARVEST SPOTTED WING DROSOPHILA Lannate, Imidan, Malathion effective against aphids and maggot when possible. Monitor with traps, and use materials that are also effective against aphids and maggot when possible. BLUEBERRY MAGGOT See list from previous newsletter

  8. Unusual thoracic radiographic findings in children treated for Hodgkin's disease

    SciTech Connect (OSTI)

    Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.

    1986-06-01

    Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

  9. Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease

    E-Print Network [OSTI]

    Galvin, James E.; Malcom, Heather; Johnson, David Kevin; Morris, John C.

    2007-05-29

    Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease James E. Galvin, MD, MPH Heather Malcom David Johnson, PhD John C. Morris, MD ABSTRACT Objective: To identify personality traits that distinguish dementia with Lewy... and differentiation in conjunction with other DLB features. METHODS Research participants. Beginning in 1979, over 3,000 individuals have been enrolled in our longitudinal studies of healthy aging and dementia and over 800 of these participants have been studied...

  10. Travel and migration associated infectious diseases morbidity in Europe, 2008

    E-Print Network [OSTI]

    Field, Vanessa; Gautret, Philippe; Schlagenhauf, Patricia; Burchard, Gerd-Dieter; Caumes, Eric; Jensenius, Mogens; Castelli, Francesco; Gkrania-Klotsas, Effrossyni; Weld, Leisa; Lopez-Velez, Rogelio; de Vries, Peter; von Sonnenburg, Frank; Loutan, Louis; Parola, Philippe; Network, the EuroTravNet

    2010-11-17

    to adjust for the large number of statistical tests performed. Ethics approval The GeoSentinel International data-collection protocol used by EuroTravNet was reviewed by the institutional review board officer at the National Center for Infec- tious Diseases... on a return visit to his country of birth Algeria; three cases of toxo- plasmosis, 20 cases of acute Epstein Barr Virus infection, and one case of histoplasmosis. Bacterial infections accounted for most dermatological diagnoses followed by arthropod...

  11. Storage and Diseases of the Sweet Potato in Texas. 

    E-Print Network [OSTI]

    Youngblood, B. (Bonney)

    1919-01-01

    STATION AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS W. B. BIZZELL, President BULLETIN TuO. 250 OCTOBER, 1919 EXPERIMENT STATION AND EXTENSION SERVICE COOPERATING STORAGE AND DISEASES OF THE SWEET POTATO IN TEXAS B. YOUNGBLOOD, DIRECTOR College... cooperation with the United States Department of Agriculture. FOREWORD. Sweet potato storage is a comparatively new industry in Texas. Dur- ing the past few years, hoaeyer, a great deal of interest has been mani- fested in improved methods of storage...

  12. A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

    E-Print Network [OSTI]

    Pagliarini, David J.

    James G. Evans,8 David R. Thorburn,5,6 Steven A. Carr,3,* and Vamsi K. Mootha1,2,3,* 1Center for HumanA Mitochondrial Protein Compendium Elucidates Complex I Disease Biology David J. Pagliarini,1 A. Walford,1,2 Canny Sugiana,5 Avihu Boneh,5,6 William K. Chen,1,2 David E. Hill,7 Marc Vidal,7

  13. Pathogenesis of human papillomavirus-associated mucosal disease

    E-Print Network [OSTI]

    Groves, Ian J.; Coleman, Nicholas

    2014-12-08

    =UTF-8 For Peer Review Pathogenesis of human papillomavirus-associated mucosal disease. Journal: The Journal of Pathology Manuscript ID: Draft Wiley - Manuscript type: Invited Review Date Submitted by the Author: n/a Complete... advantage. Selection of integrated HRHPV occurs relatively early in cervical carcinogenesis and determinants of selection have been difficult to investigate adequately using clinical samples [36]. However, the W12 model of HPV16-associated cervical...

  14. Using Genomics to Study Human Biology and Disease

    SciTech Connect (OSTI)

    Myers, Ricard M.

    2005-04-06

    The Human Genome Project culminated in April 2003 with the finished DNA sequence of all of the human chromosomes. This book of information, particularly in conjunction with the genome sequences of many other organisms, has already begun to revolutionize the way that biomedical scientists study our species. The identification of essentially all of our genes has provided a template upon which researchers can discover basic processes that govern cells, organs, and the whole organism, and to understand the fundamental causes of the diseases that occur when something goes wrong with a gene or a set of genes. The Genome Project has already made it possible to identify the genes that are defective in more than 1,000 rare inherited diseases, and these discoveries have helped to understand the mechanisms of the more common forms of these disorders. This understanding of primary defects in diseases - which is translated as mutations in genes that encode proteins that serve specific functions - is transforming the way that biotechnology and pharmaceutical companies identify drug targets, and a few notable cases have already had a striking impact on specific diseases. In addition, it has become clear that the differential response to drugs in human populations is heavily influenced by genes, and a whole field called pharmacogenetics has begun to identify these genetic factors. Such knowledge will allow physicians to prescribe drugs targeted to each individual, with the potential to increase efficacy and decrease side-effects. Determining the DNA sequence of the human genome and identifying the genes has been an exciting endeavor, but we are only just beginning to understand the treasures present in all of our DNA. My presentation will briefly describe the road we took to get the sequence, as well as the tools that we are developing to unlock its secrets.

  15. Selection of a multiple disease resistant runner-type peanut 

    E-Print Network [OSTI]

    Baring, Michael Robert

    2007-09-17

    SELECTION OF A MULTIPLE DISEASE RESISTANT RUNNER-TYPE PEANUT A Thesis by MICHAEL ROBERT BARING Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE... of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, William Rooney Committee Members, Charles Simpson James Starr Robert Lemon Head of Department, C.W. Smith May 2006 Major Subject: Plant...

  16. Disease-induced resource constraints can trigger explosive epidemics

    E-Print Network [OSTI]

    Böttcher, Lucas; Araújo, Nuno A M; Herrmann, Hans J; Helbing, Dirk

    2015-01-01

    Advances in mathematical epidemiology have led to a better understanding of the risks posed by epidemic spreading and informed strategies to contain disease spread. However, a challenge that has been overlooked is that, as a disease becomes more prevalent, it can limit the availability of the capital needed to effectively treat those who have fallen ill. Here we use a simple mathematical model to gain insight into the dynamics of an epidemic when the recovery of sick individuals depends on the availability of healing resources that are generated by the healthy population. We find that epidemics spiral out of control into "explosive" spread if the cost of recovery is above a critical cost. This can occur even when the disease would die out without the resource constraint. The onset of explosive epidemics is very sudden, exhibiting a discontinuous transition under very general assumptions. We find analytical expressions for the critical cost and the size of the explosive jump in infection levels in terms of the...

  17. Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk

    E-Print Network [OSTI]

    Koenig, Gerald

    2015-01-01

    Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT’s predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a ...

  18. Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

    E-Print Network [OSTI]

    Young, Carissa L.

    Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across ...

  19. Correlation of Klebsiella pneumoniae Comparative Genetic Analyses with Virulence Profiles in a Murine Respiratory Disease Model

    E-Print Network [OSTI]

    Fodah, Ramy A.

    Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied ...

  20. Precision medicine in chronic disease management: The multiple sclerosis BioScreen

    E-Print Network [OSTI]

    2014-01-01

    Disease Management: The Multiple Sclerosis BioScreen Pierre-unpredictable disease like multiple sclerosis? Eur J NeurolHL. The challenge of multiple sclerosis: how do we cure a

  1. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk

    E-Print Network [OSTI]

    Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus). Subsequently, the disease was diagnosed in black-tailed deer, Rocky Mountain elk (Williams & Young, 1982, 1992

  2. Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg. 

    E-Print Network [OSTI]

    Stephens LA; Malpass KH; Anderton SM

    2009-01-01

    The potential use of CD4(+)Foxp3(+) Treg as a cellular therapy for autoimmune disease is of great interest. For clinical translation, the key objective is to reverse established disease. Here we demonstrate that myelin ...

  3. Inflammation and haemostasis in the development and progression of peripheral atherosclerotic disease 

    E-Print Network [OSTI]

    Tzoulaki, Ioanna

    2007-01-01

    Peripheral arterial disease (PAD) defines atherosclerotic disease of the arteries to the legs. PAD begins early in life and remains asymptomatic over long periods. The ankle brachial index (ABI) is an important diagnostic ...

  4. Morphological, cellular and proteomic features of canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Han, Richard I-Ming

    2009-01-01

    Myxomatous mitral valve degeneration (MMVD) is the single most common cardiac disease of the dog, and is analogous to Mitral Valve Prolapse in humans. Very little is known about the aetiopathogenesis of this disease or ...

  5. Economic Consequences Associated with Johne’s Disease in Cow-Calf Operations 

    E-Print Network [OSTI]

    Bhattarai, Bikash

    2013-08-05

    Johne’s disease (JD) in cattle is a disease of economic importance caused by Mycobacterium avium subspecies paratuberculosis (MAP). Studies were conducted to estimate the losses due to lower weaning weight of beef calves ...

  6. HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF ENERGY CONSERVATION IN BUILDINGS

    E-Print Network [OSTI]

    Budnitz, R.J.

    2011-01-01

    Snihs, "The Significance of Radon and Its Progeny as NaturalDivision Human Disease from Radon Exposures: The I P ImpactVent 78-5 HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF

  7. v-abl causes hematopoietic disease distinct from that caused by bcr-abl.

    E-Print Network [OSTI]

    Scott, M L; Van Etten, R A; Daley, G Q; Baltimore, D

    1991-01-01

    Medical Sciences v-abl causes hematopoietic disease distinctcells. bcr-abl also causes a CML-like syndrome in mice whosevirus-containing sys- tem, causes disease similar to, but

  8. Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration.

    E-Print Network [OSTI]

    2007-01-01

    in Alzheimer’s disease causes neuronal death. FASEB J. 2001;Manuscript Figure 1. UbB + 1 causes neuritic beading andfound in Alzheimer’s disease causes neuritic beading of

  9. Structural Findings in the Basal Ganglia in Genetically Determined and Idiopathic Parkinson's Disease

    E-Print Network [OSTI]

    Gaser, Christian

    Structural Findings in the Basal Ganglia in Genetically Determined and Idiopathic Parkinson likely have an increased risk to develop Parkinson's disease (PD). We hypothesized BG morphological Key words: basal ganglia; magnetic resonance imaging; Parkinson's disease; Parkin mutation carriers

  10. Immunization with a Borrelia burgdorferi BB0172-Derived Peptide Protects Mice against Lyme Disease 

    E-Print Network [OSTI]

    Small, Christina M.; Ajithdoss, Dharani K.; Hoffmann, Aline Rodrigues; Mwangi, Waithaka; Esteve-Gassent, Maria D.

    2014-02-05

    Lyme disease is the most prevalent arthropod borne disease in the US and it is caused by the bacterial spirochete Borrelia burgdorferi (Bb), which is acquired through the bite of an infected Ixodes tick. Vaccine development efforts focused...

  11. The development of new tools for field and laboratory diagnosis of Pierces Disease 

    E-Print Network [OSTI]

    Bryan, Kelly Asbill

    2009-05-15

    Pierce’s Disease (PD), caused by Xylella fastidiosa, is a devastating bacterial disease of grapevines. One of the few control options is roguing. Roguing depends on precise diagnosis of PD in vines. These experiments were conducted to improve...

  12. High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women 

    E-Print Network [OSTI]

    Ghahramany, Ghazal

    2012-07-16

    About half of all deaths in developed countries are caused by cardiovascular disease. It is well known that cardiovascular disease (CVD) risk can be influenced by diet, but optimal dietary content of fatty acids continues ...

  13. Di#erential equation models for Aujeszky's Disease Virus (ADV) in Irish pig herds

    E-Print Network [OSTI]

    , Dublin City University, Dublin 9, Ireland Abstract Aujeszky's Disease virus, (ADV) is a contagious viral Aladar Aujeszky, when he distinguished psuedorabies from rabies [23]. Aujeszky's Disease is a contagious

  14. Micro-Simulations of Infectious Disease using Official Register Data The Case of Smallpox

    E-Print Network [OSTI]

    Boman, Magnus

    , for example. #12;Introduction Should an infection of a contagious disease occur, the potential threat must be seen as an example of a predominantly airborne, fairly contagious vaccine-preventable disease where

  15. Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

    E-Print Network [OSTI]

    Thompson, Paul

    Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla and Alzheimer's disease based on high resolution MRI at 3 Tesla. T1-weighted images were acquired from 19

  16. Pharmacological Chaperone Design for Reducing Risk Factor of Parkinson’s Disease from Traditional Chinese Medicine

    E-Print Network [OSTI]

    Huang, Hung-Jin

    Dysfunction of ?-glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson’s disease occurrence. Pharmacological chaperone design has been used to ...

  17. CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

    E-Print Network [OSTI]

    Rezai-Zadeh, Kavon; Gate, David; Town, Terrence

    2009-01-01

    encephalitis . multiple sclerosis . experimental autoimmunedisease (AD), multiple sclerosis (MS), and Parkinson'sdemyelinating disease multiple sclerosis) and may also be

  18. Association Analysis of the Extended MHC Region in Celiac Disease Implicates Multiple Independent Susceptibility Loci

    E-Print Network [OSTI]

    2012-01-01

    Symposium on Coeliac Disease. Tampere, Finland: Institute ofTechnology, University of Tampere. pp 265–274. 25. Hall RP,

  19. "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2

    E-Print Network [OSTI]

    Watson, Craig A.

    VM85 "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2 1. This document is VM85 fish is generically referred to as "red sore disease." This problem usually occurs in the spring on their fish. Typically, "red sore disease" is caused by two organisms, Aeromonas hydrophila , a bacterium

  20. Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases*

    E-Print Network [OSTI]

    Li, Lian

    and Parkinson Diseases* Received for publication, December 20, 2004, and in revised form, January 18, 2005 oxidative stress has been strongly impli- cated in the pathogenesis of Alzheimer disease (AD) and Parkinson(s) that could potentially be tar- geted by similar therapeutic strategies. Alzheimer disease (AD),1 Parkinson

  1. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit

    E-Print Network [OSTI]

    Guo, Ming

    of Parkinson's disease. pink1 acts upstream of parkin in a common genetic pathway to regulate mitochondrialThe Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion represent a novel therapeutic strategy for Parkinson's disease. mitofusin drp1 opa1 parkin-pink1 Parkinson

  2. 8 THE AMERICAN SOCIETY FOR CELL BIOLOGY PRESS BOOK 2004 arkinson's disease (PD) was named

    E-Print Network [OSTI]

    Feng, Jian

    as a progressive neurodegenerative disease. Parkinson's is caused by the selective death of neurons that produce-radical-damaged tubulin. In this fight, mutated parkin apparently arrives unarmed. Parkinson's Disease: Shootout8 THE AMERICAN SOCIETY FOR CELL BIOLOGY PRESS BOOK 2004 P arkinson's disease (PD) was named

  3. Neurodegeneration and Neuroprotection in Parkinson Disease Stanley Fahn and David Sulzer

    E-Print Network [OSTI]

    Sulzer, David

    Neurodegeneration and Neuroprotection in Parkinson Disease Stanley Fahn and David Sulzer Department Parkinson disease (PD) result primarily from the loss of the neuromelanin (NM)-containing dopamine (DA, with at least one of them being tremor-at-rest or brady- kinesia. Parkinson disease (PD) is the major cause

  4. Parkinson's disease (PD) is characterized by the rela-tively selective degeneration of dopaminergic neurons in

    E-Print Network [OSTI]

    Feng, Jian

    Parkinson's disease (PD) is characterized by the rela- tively selective degeneration into a stiff, hollow tube. Each Microtubule: A Common Target for Parkin and Parkinson's Disease Toxins JIAN performed on twins (Tanner and others 1999), reveal strong environmental connections to the disease

  5. Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the

    E-Print Network [OSTI]

    Shorter, James

    Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the loss motor and cognitive problems. Although the disease was first described in 1817 (Parkinson, 2002), few treatments exist today. These treatments do not target the cause of the disease and instead aim to increase

  6. Neurobiology of Disease Functional Analysis of VPS41-Mediated Neuroprotection in

    E-Print Network [OSTI]

    Caldwell, Guy

    elegans and Mammalian Models of Parkinson's Disease Adam J. Harrington,1 Talene A. Yacoubian,2 Sunny R Disruptionofthelysosomalsystemhasemergedasakeycellularpathwayintheneurotoxicityof -synuclein( -syn)andtheprogression of Parkinson's disease (PD). A large-scale RNA interference for the treatment of synucleinopathies like PD. Introduction Parkinson's disease (PD) is the second most common

  7. Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3

    E-Print Network [OSTI]

    Li, Lian

    Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase autosomal recessive forms of Parkinson disease (PD), but how these mutations trigger neurodegeneration pathway in the pathogenesis of PD. INTRODUCTION Parkinson disease (PD) is the most common neurodegenera

  8. Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis

    E-Print Network [OSTI]

    Abecasis, Goncalo

    ARTICLE Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis1,24,* Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically and enlarge the map of shared genetic risk loci. Introduction Psoriasis (PS [MIM 177900]) and Crohn disease

  9. Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease

    E-Print Network [OSTI]

    Carbonell, Jaime

    Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease Selen Uguroglu and Jaime Pittsburgh, PA 15212 Abstract We investigate machine learning methods for diagnos- tic screening of heart disease. Coronary heart disease is the leading cause of death in the US, causing more deaths than all

  10. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort

    E-Print Network [OSTI]

    van Geen, Alexander

    13 million residents in the United States.1 Although the International Agency for Research on Cancer Death from cardiovascular disease. Results 198 people died from diseases of circulatory system, accounting for 43% of total mortality in the population. The mortality rate for cardiovascular disease

  11. Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP)

    E-Print Network [OSTI]

    Charette, André

    Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP) Neurodegenerative diseases represent one of the most difficult classes of diseases for which to develop drugs, yet, offering a huge opportunity to target some of these pathways with repurposed drugs approved

  12. The Diet-Heart Hypothesis: a critical appraisal of the relationship between diet and coronary artery disease

    E-Print Network [OSTI]

    Jurewitz, Daniel L

    2007-01-01

    for Prevention of Coronary Heart Disease. JAMA. 2002;288:M. Fish consumption and coronary heart disease mortality: aacid and risk of ischemic heart disease among women. Am J

  13. Novel Synthetic Medea Selfish Genetic Elements Drive Population Replacement in Drosophila; a Theoretical Exploration of Medea-

    E-Print Network [OSTI]

    Hay, Bruce A.

    biology, maternal effect, gene drive, mosquito, dengue, malaria Insects act as vectors for a number); dengue, yellow fever, lymphatic filariasis, chikungunya, and Chagas disease (humans); Rift valley fever

  14. Detection of bone disease in dogs by radioisotope scanning 

    E-Print Network [OSTI]

    Morris, Earl Louis

    1971-01-01

    in dogs for the diagnosis and progression of bone disease was studied. Twc isotopes of strontium, Sr and 85 87m Sr, were studied. The Sr was purchased 85 commercially and the Sr was produced at the 87m Texas A8cM University Nuclear Science Center... by the irradiation oi' Sr(N05)2. Criteria for bone scanning in dogs using Sr 85 and Sr were determined. Pour normal young dogs 87m were injected with Sr and four with Sr. Doses 85 87m of 100 p&i of Sr and 1 mCi of Sr were found . to 85 87m produoe satisfactory...

  15. Development of Biomarkers for Chronic Beryllium Disease in Mice

    SciTech Connect (OSTI)

    Gordon, Terry

    2013-01-25

    Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an animal model which can be used for dissecting dose-response relationships and pathogenic mechanisms and for testing new diagnostic and treatment paradigms. We have created 3 strains of transgenic mice in which the human antigen-presenting moiety, HLA-DP, was inserted into the mouse genome. Each mouse strain contains HLA-DPB1 alleles that confer different magnitude of risk for chronic beryllium disease (CBD): HLA-DPB1*0401 (odds ratio = 0.2), HLA-DPB1*0201 (odds ratio = 15), HLA-DPB1*1701 (odds ratio = 240). Our preliminary work has demonstrated that the *1701 allele, as predicted by human studies, results in the greatest degree of sensitization in a mouse ear swelling test. We have also completed dose-response experiments examining beryllium-induced lung granulomas and identified susceptible and resistant inbred strains of mice (without the human transgenes) as well as quantitative trait loci that may contain gene(s) that modify the immune response to beryllium. In this grant application, we propose to use the transgenic and Â?normal inbred strains of mice to identify biomarkers for the progression of beryllium sensitization and CBD. To achieve this goal, we propose to compare the sensitivity and accuracy of the lymphocyte proliferation test (blood and bronchoalveolar lavage fluid) with the ELISPOT test in the three HLA-DP transgenic mice strains throughout a 6 month treatment with beryllium particles. Because of the availability of high-throughput proteomics, we will also identify changes in potential protein biomarkers in beryllium-treated mice. We will correlate these findings with the ability of the transgenic mice to develop a beryllium-specific adaptive immune response in blood and bronchoalveolar lavage (BAL) fluid. We will also determine whether beryllium-responsive CD4+ T cells in blood and BAL correlate with the onset of granuloma formation. Thus, we will provide the scientific community with biomarkers of sensitization and disease progression for CBD. These biomarkers will serve as critical tools for development of improved industrial hygiene and therapeutic interventions.

  16. The Emergence of ActualThe Emergence of Actual Human Disease as a Model forHuman Disease as a Model for

    E-Print Network [OSTI]

    Boguski, Mark S.

    + Chromosomome +e + ""icsics"" == GenomicsGenomics 1990 Human Genome Project launched1990 Human Genome Project launched 1998 Human Genome Project1998 Human Genome Project acceleratedaccelerated 20002000 ""DraftThe Emergence of ActualThe Emergence of Actual Human Disease as a Model forHuman Disease as a Model

  17. Osteogenic Sarcoma of the Maxilla: Neutron Therapy for Unresectable Disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Smoron, Geoffrey L.; Lennox, Arlene J.; Mcgee, James L.

    1999-01-01

    Purpose. To present a case study involving the use of fast neutron therapy to treat an extensive unresectable osteogenic sarcoma arising from the left maxilla. Patient. A 14-year-old male presented with a massive tumor producing severe distortion of his facial structures. He had already received six courses of chemotherapy, which had reduced his pain, but had not measurably reduced the tumor. Methods. The patient was treated with 66 MeV fast neutrons to a dose of 20.4 Gy in 13 fractions over 35 days. Results. CT assessments indicate gradually increasing calcification and noticeable reductionmore »of soft-tissue disease in the frontal sinus, orbit and maxillary antrum.There has been some recontouring of the facial structures.The boy conducts an active life, has no pain, and feels well. He was 17 years old at the last follow-up. Discussion. Fast neutrons have a greater biological effectiveness than conventional photon beams. Their use has been associated with improved chance for local control of unresectable disease.This case illustrates their effectiveness in controlling an unusual and aggressive osteogenic sarcoma of the facial bone and sinuses. « less

  18. Prenatal maternal stress programs infant stress regulation.

    E-Print Network [OSTI]

    Davis, Elysia Poggi; Glynn, Laura M; Waffarn, Feizal; Sandman, Curt A

    2011-01-01

    Programs Infant Stress Regulation Elysia Poggi Davis, PhDglucocorticoids disrupts the regulation of physiological andstress alters circadian regulation and laboratory levels of

  19. Prenatal maternal stress programs infant stress regulation.

    E-Print Network [OSTI]

    Davis, Elysia Poggi; Glynn, Laura M; Waffarn, Feizal; Sandman, Curt A

    2011-01-01

    restraint stress on the hypothalamus-pituitary- adrenal axisnucleus of the hypothalamus, hippocampus, and amygdala (

  20. Maternal Risk Factors for Congenital Cerebral Palsy

    E-Print Network [OSTI]

    Streja, Elani

    2012-01-01

    in the Renfrew and Paisley study: prospective observational2000). In the Renfrew and Paisley Study, this group reported

  1. Bead-based microfluidic immunoassay for diagnosis of Johne's disease

    SciTech Connect (OSTI)

    Wadhwa, Ashutosh [University of Tennessee, Center for Wildlife Health, Department of Forestry; Foote, Robert [ORNL; Shaw, Robert W [ORNL; Eda, Shigetoshi [ORNL

    2012-01-01

    Microfluidics technology offers a platform for development of point-of-care diagnostic devices for various infectious diseases. In this study, we examined whether serodiagnosis of Johne s disease (JD) can be conducted in a bead-based microfluidic assay system. Magnetic micro-beads were coated with antigens of the causative agent of JD, Mycobacterium avium subsp. paratuberculosis. The antigen-coated beads were incubated with serum samples of JD-positive or negative serum samples and then with a fluorescently-labeled secondary antibody (SAB). To confirm binding of serum antibodies to the antigen, the beads were subjected to flow cytometric analysis. Different conditions (dilutions of serum and SAB, types of SAB, and types of magnetic beads) were optimized for a great degree of differentiation between the JD-negative and JD-positive samples. Using the optimized conditions, we tested a well-classified set of 155 serum samples from JD negative and JD-positive cattle by using the bead-based flow cytometric assay. Of 105 JD-positive samples, 63 samples (60%) showed higher antibody binding levels than a cut-off value determined by using antibody binding levels of JD-negative samples. In contrast, only 43-49 JD-positive samples showed higher antibody binding levels than the cut-off value when the samples were tested by commercially-available immunoassays. Microfluidic assays were performed by magnetically immobilizing a number of beads within a microchannel of a glass microchip and detecting antibody on the collected beads by laser-induced fluorescence. Antigen-coated magnetic beads treated with bovine serum sample and fluorescently-labeled SAB were loaded into a microchannel to measure the fluorescence (reflecting level of antibody binding) on the beads in the microfluidic system. When the results of five bovine serum samples obtained with the system were compared to those obtained with the flow cytometer, a high level of correlation (linear regression, r2 = 0.994) was observed. In a further experiment, we magnetically immobilized antigen-coated beads in a microchannel, reacted the beads with serum and SAB in the channel, and detected antibody binding to the beads in the microfluidic system. A strong antibody binding in JD-positive serum was detected, whereas there was only negligible binding in negative control experiments. Our data suggest that the bead-based microfluidic system may form a basis for development of an on-site serodiagnosis of JD. Key Words: Mycobacterium avium ssp. paratuberculosis, Johne s disease, microfluidics, lab-on-a-chip.

  2. Classification of interstitial lung disease patterns with topological texture features

    E-Print Network [OSTI]

    Huber, Markus B; Leinsinger, Gerda; Ray, Lawrence A; Wismüller, Axel; 10.1117/12.844318

    2010-01-01

    Topological texture features were compared in their ability to classify morphological patterns known as 'honeycombing' that are considered indicative for the presence of fibrotic interstitial lung diseases in high-resolution computed tomography (HRCT) images. For 14 patients with known occurrence of honey-combing, a stack of 70 axial, lung kernel reconstructed images were acquired from HRCT chest exams. A set of 241 regions of interest of both healthy and pathological (89) lung tissue were identified by an experienced radiologist. Texture features were extracted using six properties calculated from gray-level co-occurrence matrices (GLCM), Minkowski Dimensions (MDs), and three Minkowski Functionals (MFs, e.g. MF.euler). A k-nearest-neighbor (k-NN) classifier and a Multilayer Radial Basis Functions Network (RBFN) were optimized in a 10-fold cross-validation for each texture vector, and the classification accuracy was calculated on independent test sets as a quantitative measure of automated tissue characteriza...

  3. Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease

    SciTech Connect (OSTI)

    Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

    1988-07-01

    The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

  4. Why my disease is important: metrics of disease occurrence used in the introductory sections of papers in three leading general medical journals in 1993 and 2003

    E-Print Network [OSTI]

    Gouda, Hebe N.; Powles, John W.

    2011-05-23

    stream_source_info 1478-7954-9-14.pdf.txt stream_content_type text/plain stream_size 20996 Content-Encoding UTF-8 stream_name 1478-7954-9-14.pdf.txt Content-Type text/plain; charset=UTF-8 RESEARCH Open Access Why my disease... is important: metrics of disease occurrence used in the introductory sections of papers in three leading general medical journals in 1993 and 2003 Hebe N Gouda* and John W Powles Abstract Background: We assessed the metrics used in claims about disease...

  5. Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification

    E-Print Network [OSTI]

    Tong, Lily Victoria

    2008-01-01

    Human societies face diverse health challenges including a rapidly aging population, rising incidence of metabolic disease, and increasing antibiotic resistance. These problems involve complex interactions between genes ...

  6. Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  7. Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  8. Integrated rotation systems for soilborne disease, weed and fertility management in strawberry/vegetable production

    E-Print Network [OSTI]

    2014-01-01

    dahliae infection rate of strawberry plants at the organicsoilborne diseases in strawberry using vegetable rotations.Fertility Management in Strawberry/Vegetable Production M.

  9. Possible common e,ological agent for strawberry disease and red mark syndrome in

    E-Print Network [OSTI]

    Kane, Andrew S.

    1 Possible common e,ological agent for strawberry disease and red mark Schering-Plough Animal Health, UK Possible common e,ological agent for strawberry

  10. Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

    E-Print Network [OSTI]

    2014-01-01

    Integrative Genomics Reveals Novel Molecular Pathways and7 | e1004502 Integrative Genomics of Coronary Artery Disease2012) Use of functional genomics to identify candidate genes

  11. On the multiscale modeling of heart valve biomechanics in health and disease

    E-Print Network [OSTI]

    Weinberg, Eli J.; Shahmirzadi, Danial; Mofrad, Mohammad Reza

    2010-01-01

    carried out on simulating biomechanics of mechan- ical andmodeling of heart valve biomechanics in health and diseasemodeling of heart valve biomechanics in health and disease

  12. Testing new dairy cattle for disease can boost herd health, cut costs

    E-Print Network [OSTI]

    Moore, Dale A; Adaska, J M; Higginbotham, G E; Castillo, Alejandro R Dr.; Collar, Carol; Sischo, William M

    2009-01-01

    Article t Testing new dairy cattle for disease can boosttest or exam- ine incoming cattle, although these importantin purchased groups of dairy cattle, in order to pro- vide

  13. Psoriasis in a 3-month-old infant with Kawasaki disease

    E-Print Network [OSTI]

    Liao, Yi-Chen; Lee, Julia Yu-Yun

    2009-01-01

    pincer nail deformity. Psoriasis or pityriasis lichenoides2 Figure 1. KD-associated psoriasis in the acute phase of KDFinkelstein Y. Guttate psoriasis following Kawasaki disease.

  14. Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2013-01-01

    lower leg of a patient with psoriasis vulgaris. Acta Dermleg of a patient with psoriasis vulgaris.Acta Derm Venereol.Behcet's disease, psoriasis and hidradenitis suppurativa.

  15. A model for the coupled disease dynamics of HIV and HSV-2 with ...

    E-Print Network [OSTI]

    Christina Alvey

    2015-05-19

    May 4, 2015 ... We conclude that homosexual transmission drastically changes the disease prevalences; hence, it is important to account for this interaction as ...

  16. The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Groza, Tudor; Köhler, Sebastian; Moldenhauer, Dawid; Vasilevsky, Nicole; Baynam, Gareth; Zemojtel, Tomasz; Schriml, Lynn Marie; Kibbe, Warren Alden; Schofield, Paul N.; Beck, Tim; et al

    2015-06-25

    The Human Phenotype Ontology (HPO) is widely used in the rare disease community for differential diagnostics, phenotype-driven analysis of next-generation sequence-variation data, and translational research, but a comparable resource has not been available for common disease. Here, we have developed a concept-recognition procedure that analyzes the frequencies of HPO disease annotations as identified in over five million PubMed abstracts by employing an iterative procedure to optimize precision and recall of the identified terms. We derived disease models for 3,145 common human diseases comprising a total of 132,006 HPO annotations. The HPO now comprises over 250,000 phenotypic annotations for over 10,000more »rare and common diseases and can be used for examining the phenotypic overlap among common diseases that share risk alleles, as well as between Mendelian diseases and common diseases linked by genomic location. The annotations, as well as the HPO itself, are freely available.« less

  17. Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2013-01-01

    any joint disease of the vertebral column. As such, it is ainvolvement of the vertebral column from any type of joint

  18. The role of phenoloxidase suppression in QX disease outbreaks among Sydney rock oysters

    E-Print Network [OSTI]

    Raftos, David

    disease. Oysters from the same brood stock were harvested from QX prone and QX free growing areas over negative correlation between phenoloxidase activity and the intensity of parasitic infection ( p = 0 prevented effective management of QX disease in endemic areas. Current management regimes rely only

  19. Proceedings of the 2nd workshop on lyme disease in the Southeast

    SciTech Connect (OSTI)

    Apperson, C.S. [ed.] [North Carolina State Univ., Raleigh, NC (United States). Dept. of Entomology; Levine, J.F. [ed.] [North Carolina State Univ., Raleigh, NC (United States). Dept. of Microbiology, Pathology, and Parasitology; Snoddy, E.L. [ed.] [Tennessee Valley Authority, Muscle Shoals, AL (United States)

    1993-12-31

    This volume provides author prepared abstracts of oral presentation at the Second Workshop on Lyme Disease in the Southeast head in Raleigh, North Carolina September 7-9, 1993. The 33 presentations covered various aspects of the epidemic including geographical distribution of various species of ticks, transmission risks, Lyme Disease epidemiology, and taxonomic aspects.

  20. GIS-Based Epidemiological Modeling of an Emerging Forest Disease: Spread of

    E-Print Network [OSTI]

    247 GIS-Based Epidemiological Modeling of an Emerging Forest Disease: Spread of Sudden Oak Death applied in a GIS to real-world wildland landscapes. In this paper, we present and evaluate a GIS model was implemented (1990-2005) in a GIS to simulate disease spread across California at a spatial

  1. Automated segmentation of lungs with severe interstitial lung disease in CT

    E-Print Network [OSTI]

    Automated segmentation of lungs with severe interstitial lung disease in CT Jiahui Wang Department: Accurate segmentation of lungs with severe interstitial lung disease ILD in thoracic computed tomography CT developed in this study a texture analysis-based method for accurate segmentation of lungs with severe ILD

  2. South Carolina Pest Management Handbook for Field Crops -2015 SOYBEAN DISEASE CONTROL

    E-Print Network [OSTI]

    Stuart, Steven J.

    South Carolina Pest Management Handbook for Field Crops - 2015 259 SOYBEAN DISEASE CONTROL John D years. Soybean Rust is active in South Carolina primarily after mid-August in most years. Soybean South Carolina Soybean Production Guide for information on accurate identification of diseases based

  3. Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2

    E-Print Network [OSTI]

    Watson, Craig A.

    FA181 Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2 1. This document is FA181, one and marine fishes caused by infection with an iridovirus known as Lymphocystivirus or Lymphocystis disease does not cause significant mortalities, it does cause unsightly growths on fish that reduce

  4. Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

    E-Print Network [OSTI]

    Morimoto, Richard

    Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding Daniela Martino homeostasis components that direct protein folding and function. To identify global principles of misfolding. In diseased cells, maladaptation alters protein structure­function relationships, impacts protein folding

  5. Thesis proposal CSF Brazil 2014 Dendrimers as new drugs against neglected tropical diseases

    E-Print Network [OSTI]

    Bordenave, Charles

    Thesis proposal CSF Brazil 2014 Title: Dendrimers as new drugs against neglected tropical diseases America, particularly in Brazil. The #12;disease is severe in people with weakened immune systems, finding new medications is of high interest both for France and Brazil. We propose to use dendrimers

  6. Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed countries

    E-Print Network [OSTI]

    Cai, Long

    Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed in the lungs. However, characteristic to both forms of the disease is the airway- wall accumulation of T helper are expressed either by skin8 or lung epithelial cells and can influence the way in which epithelial cells

  7. Assessing Patient Case Management Services with Adult Congenital Heart Disease Sensed Data

    E-Print Network [OSTI]

    Roussos, George

    1 Assessing Patient Case Management Services with Adult Congenital Heart Disease Sensed Data · Clinicians: Doctors & Nurses 7 How do Patients use Panaceia-iTV? Follow a treatment plan that includes-iTV Pilot Sites Brompton Hospital, London Adult Congenital Heart Center, Congenital Heart Disease Patients

  8. New Florida Cattle Identification Program to Protect Florida's Cattle Industry; Mitigate Spread of Disease

    E-Print Network [OSTI]

    Hill, Jeffrey E.

    New Florida Cattle Identification Program to Protect Florida's Cattle Industry; Mitigate Spread. In the past, Florida cattle have struggled with animal disease outbreaks, such as Brucellosis and Tuberculosis and those diseases, present in other states, still threaten our cattle today. The Florida Department

  9. A new shoot and stem disease of Eucalyptus species caused by Erwinia psidii

    E-Print Network [OSTI]

    A new shoot and stem disease of Eucalyptus species caused by Erwinia psidii T. A. Coutinho & C. L Eucalyptus grandis, E. dunnii, E. globulus and E. globulus subsp. maidenii has been observed in plantations previously observed on any species of Eucalyptus. In this study, we describe the symptoms of this new disease

  10. Mycosphaerella leaf disease (MLD) outbreak on Eucalyptus globulus in Brazil caused by Teratosphaeria (Mycosphaerella) nubilosa

    E-Print Network [OSTI]

    302 Mycosphaerella leaf disease (MLD) outbreak on Eucalyptus globulus in Brazil caused of young plantations of Eucalyptus globulus trees showing symptoms resembling My- cosphaerella leaf disease spread of T. nubilosa northwards into Brazil's main Eucalyptus-growing areas as well as to other South

  11. Plant Disease / June 2005 659 Relative Pathogenicity of Cryphonectria cubensis on Eucalyptus Clones

    E-Print Network [OSTI]

    Plant Disease / June 2005 659 Relative Pathogenicity of Cryphonectria cubensis on Eucalyptus Clones canker disease on Eucalyptus species in many tropical and subtropical areas of the world (2/year) and tem- peratures above 23°C (5,12,23). Since Eucalyptus is one of the major plantation trees

  12. Root and Root Collar Disease of Eucalyptus grandis Caused by Pythium splendens

    E-Print Network [OSTI]

    Root and Root Collar Disease of Eucalyptus grandis Caused by Pythium splendens 125 C. LINDE, M. J. H. J. 1994. Root and root collar disease of Eucalyptus gramlis caused by Pythium spJendens. Plant trees. P. splendens inoculated on two different clones of E. grandis and on Eucalyptus fastigata

  13. An Adaptive, Knowledge-Driven Medical Image Search Engine for Interactive Diffuse Parenchymal Lung Disease

    E-Print Network [OSTI]

    Chandy, John A.

    An Adaptive, Knowledge-Driven Medical Image Search Engine for Interactive Diffuse Parenchymal Lung Abstract Characterization and quantification of the severity of diffuse parenchymal lung diseases (DPLD have been obtained on a small test set. Keywords: CT; texture analysis; interstitial lung disease

  14. Monte Carlo Simulation of Alzheimer's Disease in the United States: 2010-2060

    E-Print Network [OSTI]

    Feres, Renato

    Monte Carlo Simulation of Alzheimer's Disease in the United States: 2010-2060 Michael Blech concerns facing the United States over the next 50 years. This progressive disease is currently the sixth on the United States population, and second, the simulation models both prevalence and mortality. Both

  15. Plant Disease / September 2002 939939 Differential Response of Selected Peanut (Arachis hypogaea) Genotypes

    E-Print Network [OSTI]

    Pappu, Hanu R.

    Plant Disease / September 2002 939939 Differential Response of Selected Peanut (Arachis hypogaea species of thrips (18). In the United States, the virus has become a major con- straint to peanut disease in peanut was made possible by identifying and combining some critical management tactics

  16. South Carolina Pest Management Handbook for Field Crops -2015 PEANUT DISEASE MANAGEMENT

    E-Print Network [OSTI]

    Stuart, Steven J.

    South Carolina Pest Management Handbook for Field Crops - 2015 184 PEANUT DISEASE MANAGEMENT Jay W. Chapin, Extension Peanut Specialist Emeritus Seedling Diseases: All peanut seed should be treated to peanuts by thrips, primarily tobacco thrips. TSWV reduces yield and causes shriveled, misshapen pods. All

  17. Health and Disease in East Africa Course Syllabus; Spring 2011 Interdisciplinary Perspectives on

    E-Print Network [OSTI]

    Sheridan, Jennifer

    Health and Disease in East Africa Course Syllabus; Spring 2011 1 Interdisciplinary Perspectives on Global Health and Disease: Uganda PHS 644: Section 30 Course Syllabus ­ Spring 2012 Wednesdays 5 Prerequisites: Graduate and health professional students who plan field study in Uganda and/or East Africa

  18. Monitoring Insect and Disease Impacts on Rangeland Oaks in California1

    E-Print Network [OSTI]

    information has been compiled on the relative importance and overall impacts of diseases and arthropods A. Bernhardt Richard A. Arnold2 Abstract: We developed methods to assess the impacts of diseases and arthropods on sapling and mature rangeland oaks, and applied these methods at 18 sample plot locations

  19. BETWEEN DESTINY AND DISEASE: GENETICS AND MOLECULAR PATHWAYS OF CENTRAL NERVOUS SYSTEM AGING

    E-Print Network [OSTI]

    Sibille, Etienne

    BETWEEN DESTINY AND DISEASE: GENETICS AND MOLECULAR PATHWAYS OF CENTRAL NERVOUS SYSTEM AGING BETWEEN DESTINY AND DISEASE: GENETICS AND MOLECULAR PATHWAYS OF CNS AGING Christin Ann Glorioso, Ph.D. University of Pittsburgh, 2010 Human brain aging is associated with robust "normal" functional, structural

  20. The aging-disease false dichotomy: understanding senescence as pathology Journal Name: Frontiers in Genetics

    E-Print Network [OSTI]

    Gems, David

    The aging-disease false dichotomy: understanding senescence as pathology David Gems Journal Name.frontiersin.org Citation: Gems D(2015) The aging-disease false dichotomy: understanding senescence as pathology. Front formatted PDF and full text (HTML) versions will be made available soon. Genetics of Aging #12;1 The aging

  1. Milk production and distribution in low-dose counties for the Hanford Thyroid Disease Study

    SciTech Connect (OSTI)

    Schimmel, J.G. . Social and Economic Sciences Research Center); Beck, D.M. )

    1992-06-01

    This report identifies sources of milk consumed by residents of Ferry, Okanogan, and Stevens Counties. This information will be used by the Hanford thyroid Disease Study to determine whether thyroid disease has been increased among people exposed to past iodine--131 emissions from Hanford Site Facilities.

  2. Annosus Root Disease in Europe and the Southeastern United States: Occurrence, Research, and Historical Perspective'

    E-Print Network [OSTI]

    History #12;Annosus Root Disease in Europe and the Southeastern United States: Occurrence disease in Europe and the southeastern United States is reviewed in prefacing the focus. This mode of spread has accounted for a long history of damage in Europe where losses occur as: (1

  3. Metabonomic Profiling of TASTPM Transgenic Alzheimer's Disease Mouse Model

    SciTech Connect (OSTI)

    Hu, Zeping; Browne, Edward R.; Liu, Tao; Angel, Thomas E.; Ho, Paul C.; Chun Yong Chan, Eric

    2012-12-07

    Identification of molecular mechanisms underlying early stage Alzheimer’s disease (AD) is important for the development of new therapies against and diagnosis of AD. In this study, non-targeted metabotyping of TASTPM transgenic AD mice was performed. The metabolic profiles of both brain and plasma of TASTPM mice were characterized using gas chromatography-mass spectrometry and compared to those of wild type C57BL/6J mice. TASTPM mice were metabolically distinct compared to wild type mice (Q28 Y = 0.587 and 0.766 for PLS-DA models derived from brain and plasma, respectively). A number of metabolites were found to be perturbed in TASTPM mice in both brain (D11 fructose, L-valine, L-serine, L-threonine, zymosterol) and plasma (D-glucose, D12 galactose, linoleic acid, arachidonic acid, palmitic acid and D-gluconic acid). In addition, enzyme immunoassay confirmed that selected endogenous steroids were significantly perturbed in brain (androstenedione and 17-OH-progesterone) and plasma (cortisol and testosterone) of TASTPM mice. Ingenuity pathway analysis revealed that perturbations related to amino acid metabolism (brain), steroid biosynthesis (brain), linoleic acid metabolism (plasma) and energy metabolism (plasma) accounted for the differentiation of TASTPM and wild-type

  4. Toxicological and pharmacological concerns on oxidative stress and related diseases

    SciTech Connect (OSTI)

    Saeidnia, Soodabeh; Abdollahi, Mohammad

    2013-12-15

    Although reactive oxygen species (ROS) such as superoxide, hydrogen peroxide and hydroxyl radical are generated as the natural byproduct of normal oxygen metabolism, they can create oxidative damage via interaction with bio-molecules. The role of oxidative stress as a remarkable upstream part is frequently reported in the signaling cascade of inflammation as well as chemo attractant production. Even though hydrogen peroxide can control cell signaling and stimulate cell proliferation at low levels, in higher concentrations it can initiate apoptosis and in very high levels may create necrosis. So far, the role of ROS in cellular damage and death is well documented with implicating in a broad range of degenerative alterations e.g. carcinogenesis, aging and other oxidative stress related diseases (OSRDs). Reversely, it is cleared that antioxidants are potentially able to suppress (at least in part) the immune system and to enhance the normal cellular protective responses to tissue damage. In this review, we aimed to provide insights on diverse OSRDs, which are correlated with the concept of oxidative stress as well as its cellular effects that can be inhibited by antioxidants. Resveratrol, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, statins, nebivolol and carvedilol, pentaerythritol tetranitrate, mitochondria-targeted antioxidants, and plant-derived drugs (alone or combined) are the potential medicines that can be used to control OSRD.

  5. Sedation-assisted Orthopedic Reduction in Emergency Medicine: The Safety and Success of a One Physician/One Nurse Model

    E-Print Network [OSTI]

    Vinson, David R; Hoehn, Casey

    2013-01-01

    of Emergency Physicians (ACEP) and the Emergency Nurses42 Contrary to the ACEP policy, some felt credentialed,oversight. 50-53 In 2010 ACEP, ENA, and the American Academy

  6. Mechanical Assessment of Veterinary Orthopedic Implant Technologies: Comparative Studies of Canine Fracture Fixation and Equine Arthrodesis Devices and Techniques 

    E-Print Network [OSTI]

    Baker, Sean Travis

    2013-04-30

    Plate (LCP) was compared to a 14-16 hole broad Dynamic Compression Plate (DCP). Both constructs used a two “figure-eight” 1.25mm stainless steel wire tension band. Fatigue tests and to failure tests were conducted. There were no significant differences...

  7. Health Detectives: Uncovering the Mysteries of Disease (LBNL Science at the Theater)

    ScienceCinema (OSTI)

    Bissell, Mina; Canaria, Christie; Celnicker, Susan; Karpen, Gary

    2014-05-06

    In this April 23, 2012 Science at the Theater event, Berkeley Lab scientists discuss how they uncover the mysteries of disease in unlikely places. Speakers and topics include: World-renowned cancer researcher Mina Bissell's pioneering research on the role of the cellular microenvironment in breast cancer has changed the conversation about the disease. How does DNA instability cause disease? To find out, Christie Canaria images neural networks to study disorders such as Huntington's disease. Fruit flies can tell us a lot about ourselves. Susan Celniker explores the fruit fly genome to learn how our genome works. DNA is not destiny. Gary Karpen explores how environmental factors shape genome function and disease through epigenetics.

  8. Delays in Reducing Waterborne and Water-related Infectious Diseases in China under Climate Change

    SciTech Connect (OSTI)

    Hodges, Maggie; Belle, Jessica; Carlton, Elizabeth; Liang, Song; Li, Huazhong; Luo, Wei; Freeman, Matthew C.; Liu, Yang; Gao, Yang; Hess, Jeremy; Remais, Justin V.

    2014-12-01

    Despite China’s rapid progress improving water, sanitation and hygiene (WSH) infrastructure and access, in 2011, 471 million people lacked access to improved sanitation, and 401 million people lacked access to household piped water. Infectious diseases are sensitive to changes in climate, particularly temperature, and WSH conditions. To explore possible impacts of climate change on these diseases in China in 2020 and 2030, we coupled estimates of the temperature sensitivity of diarrheal disease and three vector-borne diseases, temperature projections from global climate models using four emissions pathways, WSH-infrastructure development scenarios and projected demographic changes. By 2030, the projected impacts would delay China’s historically rapid progress toward reducing the burden of WSH-attributable infectious disease by 8-85 months. This developmental delay provides a key summary measure of the impact of climate change in China, and in other societies undergoing rapid social, economic, and environmental change.

  9. Mineral density volume gradients in normal and diseased human tissues

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Djomehri, Sabra I.; Candell, Susan; Case, Thomas; Browning, Alyssa; Marshall, Grayson W.; Yun, Wenbing; Lau, S. H.; Webb, Samuel; Ho, Sunita P.; Aikawa, Elena

    2015-04-09

    Clinical computed tomography provides a single mineral density (MD) value for heterogeneous calcified tissues containing early and late stage pathologic formations. The novel aspect of this study is that, it extends current quantitative methods of mapping mineral density gradients to three dimensions, discretizes early and late mineralized stages, identifies elemental distribution in discretized volumes, and correlates measured MD with respective calcium (Ca) to phosphorus (P) and Ca to zinc (Zn) elemental ratios. To accomplish this, MD variations identified using polychromatic radiation from a high resolution micro-computed tomography (micro-CT) benchtop unit were correlated with elemental mapping obtained from a microprobe X-raymore »fluorescence (XRF) using synchrotron monochromatic radiation. Digital segmentation of tomograms from normal and diseased tissues (N=5 per group; 40-60 year old males) contained significant mineral density variations (enamel: 2820-3095mg/cc, bone: 570-1415mg/cc, cementum: 1240-1340mg/cc, dentin: 1480-1590mg/cc, cementum affected by periodontitis: 1100-1220mg/cc, hypomineralized carious dentin: 345-1450mg/cc, hypermineralized carious dentin: 1815-2740mg/cc, and dental calculus: 1290-1770mg/cc). A plausible linear correlation between segmented MD volumes and elemental ratios within these volumes was established, and Ca/P ratios for dentin (1.49), hypomineralized dentin (0.32-0.46), cementum (1.51), and bone (1.68) were observed. Furthermore, varying Ca/Zn ratios were distinguished in adapted compared to normal tissues, such as in bone (855-2765) and in cementum (595-990), highlighting Zn as an influential element in prompting observed adaptive properties. Hence, results provide insights on mineral density gradients with elemental concentrations and elemental footprints that in turn could aid in elucidating mechanistic processes for pathologic formations.« less

  10. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    SciTech Connect (OSTI)

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-12-04

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  11. Development of a Discrete Spatial-Temporal SEIR Simulator for Modeling Infectious Diseases

    SciTech Connect (OSTI)

    McKenna, S.A.

    2000-11-01

    Multiple techniques have been developed to model the temporal evolution of infectious diseases. Some of these techniques have also been adapted to model the spatial evolution of the disease. This report examines the application of one such technique, the SEIR model, to the spatial and temporal evolution of disease. Applications of the SEIR model are reviewed briefly and an adaptation to the traditional SEIR model is presented. This adaptation allows for modeling the spatial evolution of the disease stages at the individual level. The transmission of the disease between individuals is modeled explicitly through the use of exposure likelihood functions rather than the global transmission rate applied to populations in the traditional implementation of the SEIR model. These adaptations allow for the consideration of spatially variable (heterogeneous) susceptibility and immunity within the population. The adaptations also allow for modeling both contagious and non-contagious diseases. The results of a number of numerical experiments to explore the effect of model parameters on the spread of an example disease are presented.

  12. Tissue-engineered canine mitral valve constructs as In vitro research models for myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Liu, Mengmeng

    2014-11-28

    Myxomatous mitral valve disease (MMVD) is one of the most common degenerative cardiac diseases affecting humans and dogs; however, its pathogenesis is not completely understood. This study focussed on developing ...

  13. Understanding Foodborne Disease Outbreaks Using Environmental Assessments Kristin C. Delea,* Carol A. Selman, and EHS-Net

    E-Print Network [OSTI]

    Understanding Foodborne Disease Outbreaks Using Environmental Assessments Kristin C. Delea,* Carol foodborne disease surveillance system. The environmental assessments of these investigations provide food environmental assessments. Methods The study was conducted by the Environmental Health Specialists Network (EHS

  14. Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease

    E-Print Network [OSTI]

    Ananthakrishnan, Ashwin N.

    AB Background: Vitamin D may have an immunologic role in Crohn's disease (CD) and ulcerative colitis (UC). Retrospective studies suggested a weak association between vitamin D status and disease activity but have significant ...

  15. Non-toxic concentrations of ?-synuclein exacerbate Parkinson's disease-like cell death by inducing mitochondrial dysfunction 

    E-Print Network [OSTI]

    Williamson, Sally Joanne Mary

    2008-01-01

    ?-Synuclein (?-syn), is a self-aggregating protein that has been identified as a pathologically important component in a number of diseases, such as Parkinson’s disease (PD). PD, a progressive neurological disorder ...

  16. Genome-wide analysis of Marek's disease virus proteins and their role in modulating the innate immune response in chickens 

    E-Print Network [OSTI]

    Hassanin, Ola

    2010-01-01

    Marek’s disease virus (MDV), the causative agent of Marek’s disease in chicken, is an important oncogenic avian pathogen which leads to world-wide economic losses in the poultry industry. It targets the chicken's immune ...

  17. Identification of novel genetic determinants in the high prevalence early-onset inflammatory bowel disease population in Scotland 

    E-Print Network [OSTI]

    Limbergen, Johan Emiel van

    2010-01-01

    Background & aims: The inflammatory bowel diseases (IBD), Crohn?s disease (CD) and ulcerative colitis (UC), are common causes of chronic gastrointestinal morbidity, affecting up to 1 in 250 of the general population in ...

  18. Chaperone networks: Tipping the balance in protein folding diseases Cindy Voisine, Jesper Sndergaard Pedersen, Richard I. Morimoto

    E-Print Network [OSTI]

    Morimoto, Richard

    Review Chaperone networks: Tipping the balance in protein folding diseases Cindy Voisine, Jesper . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Molecular chaperones and protein folding quality control . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 C. elegans models of diseases of protein folding

  19. Urine Protein Analysis and Correlation of Urinary Biomarkers with Renal Disease Progression in Dogs with X-Linked Hereditary Nephropathy 

    E-Print Network [OSTI]

    Nabity, Mary B.

    2012-02-14

    Chronic kidney disease (CKD) is a major cause of illness in dogs, and it is commonly caused by glomerular diseases that result in proteinuria and a progressive decline in renal function. Despite the importance of glomerular ...

  20. Large-scale epidemiological data on cardiovascular diseases and diabetes in migrant and ethnic minority groups in Europe 

    E-Print Network [OSTI]

    Rafnsson, Snorri B; Bhopal, Raj

    2009-01-01

    Data on differences by ethnicity in cardiovascular diseases (CVDs) and diabetes, reflecting the influence of diverse cultural, social and religious factors, are important to providing clues to disease aetiology and ...

  1. The Effects of Disease-Induced Juvenile Mortality on the Transient and Asymptotic Population Dynamics of Chinook Salmon (Oncorhynchus tshawytscha) 

    E-Print Network [OSTI]

    Fujiwara, Masami; Mohr, Michael S.; Greenberg, Aaron

    2014-01-10

    The effects of an increased disease mortality rate on the transient and asymptotic dynamics of Chinook salmon (Oncorhynchus tshawytscha) were investigated. Disease-induced mortality of juvenile salmon has become a serious concern in recent years...

  2. Quantifying the patient population of ultra-orphan diseases: a case study in X-Linked Hypohidrotic Ectodermal Dysplasia

    E-Print Network [OSTI]

    Hermann, Julie (Julie Lynn)

    2011-01-01

    Understanding the true incidence and prevalence of a disease has tremendous value for the biopharmaceutical industry, particularly for orphan diseases that affect a minority of the population (in the US, the definition of ...

  3. Cancer diseases are among the leading cause of death in the United States. Advanced cancer diseases are characterized by genetic defects resulting in uncontrollable cell growth. Currently, chemotherapeutics are one

    E-Print Network [OSTI]

    Cancer diseases are among the leading cause of death in the United States. Advanced cancer diseases of the mainstream treatments administered to cancer patients but are less effective if administered in the later with cancer diseases, by administering genes which encode for proteins that result in cell death. While

  4. A New Canker Disease of Apple, Pear, and Plum Rootstocks Caused by Diaporthe ambigua in South Africa

    E-Print Network [OSTI]

    A New Canker Disease of Apple, Pear, and Plum Rootstocks Caused by Diaporthe ambigua in South., Wingfield. B. D.. Wingfield. M. 1., and Calitz. F. J. 1996. A new canker disease of apple. pear, and plum was found to be the c:J.useof a newly recognized disease of apple. pear, and plum rootstocks in South Africa

  5. Climate Change and Disease Ecology You are invited to join Drew Harvell, Kelly Zamudio, and Laura Harrington for a lunch

    E-Print Network [OSTI]

    Walter, M.Todd

    Climate Change and Disease Ecology You are invited to join Drew Harvell, Kelly Zamudio, and Laura Future (CCSF) on "Climate Change and Disease Ecology". Our goal is to provide a forum for discussion studies of disease ecology and climate change. We are interesting to discuss initially effects

  6. In 2005, an outbreak of West Nile virus (WNV) disease occurred in Sacramento County, California; 163 human cas-

    E-Print Network [OSTI]

    Peterson, Robert K. D.

    In 2005, an outbreak of West Nile virus (WNV) disease occurred in Sacramento County, California, the Sacramento-Yolo Mosquito and Vector Control District conducted an emergency aerial spray. We determined disease. WNV disease in Sacramento County cost $2.28 million for medical treatment and patients' pro

  7. Neurobiology of Disease Loss-of-Function Analysis Suggests That Omi/HtrA2 Is Not

    E-Print Network [OSTI]

    Guo, Ming

    words: Parkinson's disease; mitochondrial protease; Omi/HtrA2; Pink1; genetic interactions; Drosophila in sporadic Parkinson's disease (PD) patients, leading tothedesignationofOmi/HtrA2asPDlocus13(PARK13).G399 Introduction Parkinson's disease (PD) is characterized by degeneration of ni- grostriatal dopaminergic neurons

  8. Integrated training in Lung Biology and Diseases Sponsored by the Division of Pulmonary and Critical Care Medicine

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    Integrated training in Lung Biology and Diseases Sponsored by the Division of Pulmonary Obstructive Pulmonary Disease (COPD, Emphysema) 3 Pulmonary Infections 4 Lung Cancer 5 Cystic Fibrosis 6 Lung Transplantation 7 Pulmonary Hypertension 8 Pulmonary Embolism 9 Occupational Lung Diseases 10 Airway Allergic

  9. Reprogramming of CTLs into natural killer-like cells in celiac disease

    E-Print Network [OSTI]

    2006-01-01

    after treatment with a gluten-free diet. Gastrointest.celiac disease on a gluten-free diet: slow and incompleteT cell lymphoma; G F D , gluten-free diet; I E - C T L ,

  10. Global warming and the potential spread of vector-borne diseases

    SciTech Connect (OSTI)

    Patz, J.

    1996-12-31

    Climatic factors influence many vector-borne infectious diseases, in addition to demographic, biological, and ecological determinants. The United Nation`s Intergovernmental Panel on Climate Change (IPCC) estimates an unprecedented global rise of 2.0 C by the year 2100. Of major concern is that these changes can affect the spread of many serious infectious diseases, including malaria and dengue fever. Global warming would directly affect disease transmission by shifting the mosquito`s geographic range, increasing reproductive and biting rates, and shortening pathogen incubation period. Human migration and damage to health infrastructures from the projected increase in climate variability and sea level rise could indirectly contribute to disease transmission. A review of this literature, as well as preliminary data from ongoing studies will be presented.

  11. Spatio-temporal relationships between feral hogs and cattle with implicatons for disease transmission 

    E-Print Network [OSTI]

    Deck, Aubrey Lynn

    2007-09-17

    ) could harbor and shed disease in areas used by domestic livestock such as cattle (Bos taurus). Extent of risk logically depends on spatio-temporal interactions between species. I used Global Positioning System (GPS) collars on cattle and hogs...

  12. Unraveling the mystery of compost teas used for organic disease and insect pest

    E-Print Network [OSTI]

    Unraveling the mystery of compost teas used for organic disease and insect GilleN #12;What are compost teas? · Watery extracts (teas) made from placing compost in a mesh bag and soaking in water · Plant vs. animal (manure

  13. Developing effective chronic disease interventions in Africa: insights from Ghana and Cameroon

    E-Print Network [OSTI]

    de-Graft Aikins, Ama; Boynton, Petra; Atanga, Lem L.

    2010-04-19

    - vant to secondary prevention. Sedentary lifestyles have been strongly implicated in Ghana's chronic disease burden [45]. However there is also an emerging keep-fit culture in urban and rural fit and football clubs are also common across the country...

  14. Pathophysiology of Parkinson's Disease: From Clinical Neurology to Basic Neuroscience and Back

    E-Print Network [OSTI]

    Friedman, Nir

    Pathophysiology of Parkinson's Disease: From Clinical Neurology to Basic Neuroscience and Back of the basic research is oriented toward the study of tremor. In this review, we use the PD tremor as our main

  15. Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease

    E-Print Network [OSTI]

    von Maltzahn, Geoffrey

    Biomarkers are becoming increasingly important in the clinical management of complex diseases, yet our ability to discover new biomarkers remains limited by our dependence on endogenous molecules. Here we describe the ...

  16. Mechanisms of Coxsackievirus B3 dissemination and persistence in the Host : consequences for neurodegenerative disease

    E-Print Network [OSTI]

    Robinson, Scott Michael; Robinson, Scott Michael

    2012-01-01

    to research on multiple sclerosis. Ann Neurol 60: 12-21. 24.s disease and multiple sclerosis. American Microbiologyin a mouse model of multiple sclerosis. The induction of key

  17. Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy

    E-Print Network [OSTI]

    2009-01-01

    myocytes of leptomeningeal vessels. Acta Neuropathol 87:233–amyloid in the cortical vessel wall in Alzheimer’s disease.beta from neurons to vessels, contributing to amyloid

  18. Vitamin C and Treating Coronary Artery Disease: More Hype than Hope?

    E-Print Network [OSTI]

    Elboudwarej, Omeed

    2010-01-01

    dietary allowance for vitamin C based on antioxidant andIn: Packer L, Fuchs J, eds. Vitamin C in health and disease.Antioxidant activity of vitamin C in iron-overloaded human

  19. Three surveillance systems for describing the spatial distribution of Johne's disease seropositivity in Texas cattle 

    E-Print Network [OSTI]

    Pearce, Brielle H.

    2009-05-15

    is able to persist in the environment of cattle for extended periods of time; therefore the distribution of the disease depends on the presence of infected animals and environmental conditions. Three surveillance systems were used to describe the spatial...

  20. Efficacy of DVD Technology in Chronic Obstructive Pulmonary Disease Self- Management Education of Rural Patients 

    E-Print Network [OSTI]

    Stellefson, Michael L.

    2010-01-14

    Despite the efficacy of pulmonary rehabilitation programs which assist patients in managing chronic obstructive pulmonary disease (COPD), the high costs and lack of availability of such programs pose considerable barriers ...

  1. Monitoring Motor Fluctuations in Patients With Parkinson's Disease Using Wearable Sensors

    E-Print Network [OSTI]

    Patel, Shyamal

    This paper presents the results of a pilot study to assess the feasibility of using accelerometer data to estimate the severity of symptoms and motor complications in patients with Parkinson's disease. A support vector ...

  2. Genetic approaches to studying coronary heart disease in SR-BI/apoE double knockout mice

    E-Print Network [OSTI]

    Karackattu, Sharon Liz

    2006-01-01

    Coronary heart disease (CHD) is a major healthcare concern in both developed and developing nations. The principal cause of CHD is atherosclerosis, the buildup of fatty deposits in vessel walls. SR-BI/apoE double knockout ...

  3. An Environmental Perspective to Decision-making for the Control of Johne's Disease on Beef Ranches 

    E-Print Network [OSTI]

    Benjamin, Lisa A.

    2010-10-12

    Biosecurity practices for Mycobacterium avium subsp. paratuberculosis (Mptb), the etiologic agent for Johne's disease (JD), are predicated on the fact that fecal-oral is the major route of infection and that Mptb is present ...

  4. Proteomic response to metabolic stress and cellular dysfunction in relation to Alzheimer's disease 

    E-Print Network [OSTI]

    Herrmann, Abigail Grace

    2014-06-28

    Vascular risk factors inducing a state of chronic cerebral hypoperfusion and metabolic stress are thought to influence the onset and progression of Alzheimer’s disease (AD). To investigate the complex molecular ...

  5. Non-invasive markers of inflammation in cystic fibrosis lung disease 

    E-Print Network [OSTI]

    MacGregor, Gordon

    2010-01-01

    Cystic fibrosis (CF) lung disease is characterised by early airways infection and inflammation, chronic suppuration, frequent infective exacerbations and an increased influx of acute, and chronic inflammatory cells. The ...

  6. White matter integrity and visual short-term memory binding in familial Alzheimer's disease 

    E-Print Network [OSTI]

    Heikkila, Heini

    2011-11-23

    The asymptomatic phase of familial Alzheimer’s disease caused by E280A mutation in presenilin-1 gene is characterized by intact performance in traditional neuropsychological tasks including memory, language, and executive ...

  7. Non-invasive assessment of ventilation maldistribution in lung disease using multiple breath inert gas washouts. 

    E-Print Network [OSTI]

    Horsley, Alex

    2009-01-01

    Clinical research in cystic fibrosis (CF) requires study endpoints that are sensitive to airways disease, repeatable and non-invasive. Despite significant advances in the treatment of CF, lung function assessments continue ...

  8. Systematic review and meta-analysis of transgenic mouse models of Alzheimer’s disease 

    E-Print Network [OSTI]

    Egan, Kieren

    2014-07-05

    The increasing prevalence of Alzheimer’s disease poses a considerable socioeconomic challenge in the years ahead. There are few clinical treatments available and none capable of halting or slowing the progressive nature ...

  9. Dual task performance in early Alzheimer's disease, amnestic mild cognitive impairment and depression 

    E-Print Network [OSTI]

    Tierney, K. M.; Lonie, J. A.; Donaghey, C.; Ebmeier, K. P.; Lee, A.; Herrmann, L. L.; O'Carroll, R. E.

    Background. The dual task paradigm (Baddeley et al. 1986; Della Sala et al. 1995) has been proposed as a sensitive measure of Alzheimer's dementia, early in the disease process. Method. We investigated this claim by ...

  10. Effects of a High Oleic Acid Beef Diet on Cardiovascular Disease Risk Factors of Human Subjects 

    E-Print Network [OSTI]

    Adams, Thaddeus Hunter

    2012-10-19

    The consumption of high-fat hamburger enriched with saturated fatty acids (SFA) and trans-fatty acids (TFA) may increase risk factors for cardiovascular disease, whereas hamburger enriched with monounsaturated fatty acids ...

  11. Role of domestic dogs in diseases of significance to humans and wildlife health in central Chile 

    E-Print Network [OSTI]

    Acosta-Jamett, Gerardo

    2010-01-01

    The higher proximity among humans, domestic animals and wildlife favours disease spill-over both from wildlife to domestic animals and vice versa, which is a potential risk for the extinction of wildlife populations and ...

  12. Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

    E-Print Network [OSTI]

    Davidson, Robert M.

    This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular ...

  13. Letter Fluency in Motor Neurone Disease: Is there a specific action word deficit? 

    E-Print Network [OSTI]

    Fawns-Ritchie, Chloe

    2013-03-13

    Recent studies have demonstrated that there is a specific verb, or action word, deficit in patients with a comorbid diagnosis of Motor Neurone Disease (MND) and dementia of the frontotemporal type. However, there has been less research examining...

  14. Giving Meaning to Movement: Evidence for Embodied Semantics from Motor Neurone Disease 

    E-Print Network [OSTI]

    Homberger, Maximilian

    2012-11-28

    evidence from behavioural and neuropsychological research, the focal onset and insidious spread of motor symptoms in Motor Neurone Disease (MND) provides a unique opportunity to investigate whether the close relationship between movement and language...

  15. Thinking and behaviour in motor neurone disease : a clinical neuropsychological investigation 

    E-Print Network [OSTI]

    Dunlop, Alan

    2007-01-01

    Traditionally Motor Neurone Disease (MND) has been thought of as a syndrome exclusively affecting the motor regions of the cortex only. However, recent research has found evidence of extra-motor involvement in patients ...

  16. Is there a relationship between Dichaena rugosa and beech bark disease?

    E-Print Network [OSTI]

    Boyer, Edmond

    Is there a relationship between Dichaena rugosa and beech bark disease? Eberhard O. SPEER of the host tissue (Speer, 1971), so is parasitism on bark. In our case, the infected periderm thickens often

  17. Text-mining applied to autoimmune disease research: the Sjögren¿s syndrome knowledge base

    E-Print Network [OSTI]

    Gorr, Sven-Ulrik; Wennblom, Trevor J; Horvath, Steve; Wong, David TW; Michie, Sara A

    2012-01-01

    as: Gorr et al. : Text-mining applied to autoimmune diseaseARTICLE Open Access Text-mining applied to autoimmunein the field, we used text mining to generate the Sjögren’s

  18. TOM: a web-based integrated approach for identification of candidate disease genes

    E-Print Network [OSTI]

    Nardini, Christine

    TOM: a web-based integrated approach for identification of candidate disease genes Simona Rossi on this principle, we present here TOM, a web-based resource for the efficient extraction of candidate genes

  19. Telomere Length in Circulating Leukocytes Is Associated with Lung Function and Disease

    E-Print Network [OSTI]

    Nyholt, Dale R.

    Telomere Length in Circulating Leukocytes Is Associated with Lung Function and Disease Eva Albrecht. Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany

  20. Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease

    E-Print Network [OSTI]

    Sarkar, Sovan

    Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology of lipid-storage disorders is not ...

  1. Ageing and Dual Task Ability - Development of a new test for Alzheimer's Disease 

    E-Print Network [OSTI]

    Young, Gregor

    2009-07-03

    Patients with Alzheimer’s disease (AD) display a specific deficit in the ability to perform dual tasks requiring working memory. This executive function deficit has been shown in a number of different research paradigms ...

  2. A study of motor control in healthy subjects and in Parkinson's disease patients

    E-Print Network [OSTI]

    Levy-Tzedek, Shelly

    2008-01-01

    Parkinson's disease (PD) is a primarily motor disorder which affects at least half a million people in the US alone. Deep brain stimulation (DBS) is a neurosurgical intervention by which neural structures are stimulated ...

  3. Mycosphaerella and Teratosphaeria diseases of Eucalyptus; easily confused and with serious consequences

    E-Print Network [OSTI]

    REVIEW Mycosphaerella and Teratosphaeria diseases of Eucalyptus; easily confused and with serious important plant pathogens, notably on native and commer- cially propagated Eucalyptus species where occurring on Eucalyptus. These studies have also enabled refinement of anamorph and teleomorph generic

  4. Mycosphaerellaceae and Teratosphaeriaceae associated with Eucalyptus leaf diseases and stem cankers in Uruguay

    E-Print Network [OSTI]

    Mycosphaerellaceae and Teratosphaeriaceae associated with Eucalyptus leaf diseases and stem cankers represent one of the most important impediments to Eucalyptus plantation forestry. Yet they have been resulting from surveys in all major Eucalyptus growing areas of the country. Species identification

  5. Cognition in healthy aging and Parkinson's disease : structural and functional integrity of neural circuits

    E-Print Network [OSTI]

    Ziegler, David A. (David Allan)

    2011-01-01

    This dissertation documents how healthy aging and Parkinson's disease (PD) affect brain anatomy and physiology and how these neural changes relate to measures of cognition and perception. While healthy aging and PD are ...

  6. Home Grounds & Animals 2015 Control of Ornamental Diseases...................................................................................... 4-3

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    ......................................................................................... 4-3 Determine the Nature of a Disease Problem by Using the Index of Ornamental Plants..................................................... 4-35 Plant Injury-37 continued #12;Home Grounds & Animals 2015 Table 4.6 - List of Common Insecticide Mixtures

  7. Natural Product Biosynthesis: Friend or Foe? From Anti-tumor Agent to Disease Causation 

    E-Print Network [OSTI]

    Foulke-Abel, Jennifer

    2012-02-14

    biological systems adversely. This work implements recent advances in genomic, proteomic and microbiological technologies to understand further biosynthetic molecules that may influence progression of human disease. Azinomycin A and B are antitumor...

  8. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

    E-Print Network [OSTI]

    Yin, Hao

    We demonstrate CRISPR-Cas9–mediated correction of a Fah mutation in hepatocytes in a mouse model of the human disease hereditary tyrosinemia. Delivery of components of the CRISPR-Cas9 system by hydrodynamic injection ...

  9. Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein 

    E-Print Network [OSTI]

    Herlihy, Sarah E

    2014-06-05

    The work in this dissertation links two diseases through a protein secreted by Dictyostelium discoideum cells. The protein, AprA, inhibits cell proliferation and induces chemorepulsion (movement away) of Dictyostelium cells. This has implications...

  10. Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease

    E-Print Network [OSTI]

    Desikan, Rahul S.

    Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...

  11. The contribution of disease focused nonprofits to biomedical research and development

    E-Print Network [OSTI]

    Polis Schutz, Jordanna

    2013-01-01

    Patient-centered, disease-focused nonprofits are playing an increasingly prominent role in accelerating the development of new diagnostics, drugs, and therapies. They are engaging in a variety of complex venture philanthropic ...

  12. Cellular Senescence in Livers from Children with End Stage Liver Disease

    E-Print Network [OSTI]

    2010-01-01

    Liver Disease Gabriela Gutierrez-Reyes 1. , Maria del Carmenprogression. Citation: Gutierrez-Reyes G, Garcia de Leon21, 2010 Copyright: ß 2010 Gutierrez-Reyes et al. This is an

  13. Functional Genomics of Brain Aging and Alzheimer’s Disease: Focus on Selective Neuronal Vulnerability

    E-Print Network [OSTI]

    Wang, Xinkun; Michaelis, Mary L.; Michaelis, Elias K.

    2010-10-21

    Pivotal brain functions, such as neurotransmission, cognition, and memory, decline with advancing age and, especially, in neurodegenerative conditions associated with aging, such as Alzheimer’s disease (AD). Yet, deterioration in structure...

  14. Intestinal Microbiota and Its Functional Aspects in Dogs with Gastrointestinal Diseases 

    E-Print Network [OSTI]

    Minamoto, Yasushi

    2015-08-05

    health and play a pivotal role in the pathogenesis of GI diseases. This study aimed to evaluate the relationship between an enteric pathogen and intestinal dysbiosis, and to describe the functional aspects of the intestinal microbiota in dogs with GI...

  15. Methionine Sulfoxide Reductase in Neurodegenerative Disease and Locomotor-Associated Dopamine Signaling

    E-Print Network [OSTI]

    Oien, Derek Brandon

    2010-04-28

    oxygen species and the methionine sulfoxide reductase system is disrupted in the aging process. This loss of antioxidant homeostasis can result in disease, and neurons may be particularly susceptible to the impact of methionine sulfoxide in proteins. Here...

  16. TREAT TO TARGET: A PROPOSED NEW PARADIGM FOR THE MANAGEMENT OF CROHN'S DISEASE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    TREAT TO TARGET: A PROPOSED NEW PARADIGM FOR THE MANAGEMENT OF CROHN'S DISEASE Short title: Treat Service des Maladie de l'Appareil Digestif et INSERM U991, Centre Hospitalier Universitaire Pontchaillou

  17. Participatory epidemiology : harnessing the HealthMap platform for community-based disease outbreak monitoring

    E-Print Network [OSTI]

    Freifeld, Clark

    2010-01-01

    Due to increasing global trade and travel along with a range of environmental factors, emerging infectious diseases such as Severe Acute Respiratory Syndrome (SARS), drug-resistant tuberculosis, and 2009 HiNi continue to ...

  18. The Regulation of Growth Factor Signaling in Drosophila Development and Disease 

    E-Print Network [OSTI]

    Lindner, Jonathan Ryan

    2012-02-14

    Developmental signaling pathways have many diverse roles throughout the life of an organism. The proper regulation of these pathways is essential for normal development, and misregulation can lead to diseases such as cancer. ...

  19. Low levels of cardiovascular risk factors and coronary heart disease in a UK Chinese population. 

    E-Print Network [OSTI]

    Harland, J O; Unwin, Nigel; Bhopal, Raj; White, M; Watson, B; Laker, M; Alberti, K G

    1997-01-01

    OBJECTIVE: To compare the prevalence of cardiovascular risk factors and coronary heart disease in Chinese and Europid adults. DESIGN: Population based, cross sectional survey. SETTING: Newcastle upon Tyne, UK, 1991-93. ...

  20. Pests and diseases It has long been recognised that climatic conditions influence the epidemiology and

    E-Print Network [OSTI]

    and incidence of many pests and diseases. Now, with the growing acceptance that man's activities are causing those in other countries that rely more on native species and local provenances. The accidental transfer

  1. Review article Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet

    E-Print Network [OSTI]

    Seneff, Stephanie

    Review article Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet and Computer Science, MIT Cambridge, MA, USA b Independent Reader of Research, Leeds, United Kingdom c Comando

  2. High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model

    E-Print Network [OSTI]

    Wu, Chaohong

    To identify Huntington's Disease therapeutics, we conducted high-content small molecule and RNAi suppressor screens using a Drosophila primary neural culture Huntingtin model. Drosophila primary neurons offer a sensitive ...

  3. Patterns of health and disease have undergone dramatic transitions during human history, reflecting social and

    E-Print Network [OSTI]

    Vermont, University of

    evolved (Ewald 1994). A second transition occurred during the Industrial Revolution.The in- cidence and with urbanization during the Industrial Revolution. The recent emergence and reemergence of infectious diseases

  4. The Unknown Ecology of an Environmental Pathogen: Buruli ulcer Disease in West Africa

    E-Print Network [OSTI]

    Campbell, Lindsay P.

    2013-11-20

    GIS DAY 2013 THE UNKNOWN ECOLOGY OF AN ENVIRONMENTAL PATHOGEN: BURULI ULCER DISEASE IN WEST AFRICA LINDSAY CAMPBELL ECOLOGY AND EVOLUTIONARY BIOLOGY UNIVERSITY OF KANSAS Buruli Ulcer Disease (BU) ? Mycobacterium ulcerans (MU) ? Environmental... Africa using a correlative modeling approach Images courtesy of Lindsay Campbell and http://www.who.int/buruli/photos Occurrence Data ? Laboratory confirmed cases ? (1997 – 2006) ? Sampling bias ? Random points ? 3 data sets ? ~275 locations...

  5. Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells

    SciTech Connect (OSTI)

    Vi, Linda; Feng, Lucy; Zhu, Rebecca D.; Wu, Yan; Lawson Health Research Institute, London, Ontario ; Satish, Latha; Gan, Bing Siang; Lawson Health Research Institute, London, Ontario; Department of Surgery, University of Western Ontario, London, Ontario; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario; Department of Medical Biophysics, University of Western Ontario, London, Ontario ; O'Gorman, David B.

    2009-12-10

    Dupuytren's disease, (DD), is a fibroproliferative condition of the palmar fascia in the hand, typically resulting in permanent contracture of one or more fingers. This fibromatosis is similar to scarring and other fibroses in displaying excess collagen secretion and contractile myofibroblast differentiation. In this report we expand on previous data demonstrating that POSTN mRNA, which encodes the extra-cellular matrix protein periostin, is up-regulated in Dupuytren's disease cord tissue relative to phenotypically normal palmar fascia. We demonstrate that the protein product of POSTN, periostin, is abundant in Dupuytren's disease cord tissue while little or no periostin immunoreactivity is evident in patient-matched control tissues. The relevance of periostin up-regulation in DD was assessed in primary cultures of cells derived from diseased and phenotypically unaffected palmar fascia from the same patients. These cells were grown in type-1 collagen-enriched culture conditions with or without periostin addition to more closely replicate the in vivo environment. Periostin was found to differentially regulate the apoptosis, proliferation, {alpha} smooth muscle actin expression and stressed Fibroblast Populated Collagen Lattice contraction of these cell types. We hypothesize that periostin, secreted by disease cord myofibroblasts into the extra-cellular matrix, promotes the transition of resident fibroblasts in the palmar fascia toward a myofibroblast phenotype, thereby promoting disease progression.

  6. Role of paraoxonase 1 (PON1) in organophosphate metabolism: Implications in neurodegenerative diseases

    SciTech Connect (OSTI)

    Androutsopoulos, Vasilis P.; Kanavouras, Konstantinos; Tsatsakis, Aristidis M.

    2011-11-15

    Organophosphate pesticides are a class of compounds that are widely used in agricultural and rural areas. Paraoxonase 1 (PON1) is a phase-I enzyme that is involved in the hydrolysis of organophosphate esters. Environmental poisoning by organophosphate compounds has been the main driving force of previous research on PON1 enzymes. Recent discoveries in animal models have revealed the important role of the enzyme in lipid metabolism. However although PON1 function is well established in experimental models, the contribution of PON1 in neurodegenerative diseases remains unclear. In this minireview we summarize the involvement of PON1 genotypes in the occurrence of Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. A brief overview of latest epidemiological studies, regarding the two most important PON1 coding region polymorphisms PON1-L55M and PON1-Q192R is presented. Positive and negative associations of PON1 with disease occurrence are reported. Notably the MM and RR alleles contribute a risk enhancing effect for the development of some neurodegenerative diseases, which may be explained by the reduced lipoprotein free radical scavenging activity that may give rise to neuronal damage, through distinct mechanism. Conflicting findings that fail to support this postulate may represent the human population ethnic heterogeneity, different sample size and environmental parameters affecting PON1 status. We conclude that further epidemiological studies are required in order to address the exact contribution of PON1 genome in combination with organophosphate exposure in populations with neurodegenerative diseases.

  7. Multiplexed Molecular Assays for Rapid Rule-Out of Foot-and-Mouth Disease

    SciTech Connect (OSTI)

    Lenhoff, R; Naraghi-Arani, P; Thissen, J; Olivas, J; Carillo, C; Chinn, C; Rasmussen, M; Messenger, S; Suer, L; Smith, S M; Tammero, L; Vitalis, E; Slezak, T R; Hullinger, P J; Hindson, B J; Hietala, S; Crossley, B; Mcbride, M

    2007-06-26

    A nucleic acid-based multiplexed assay was developed that combines detection of foot-and-mouth disease virus (FMDV) with rule-out assays for two other foreign animal diseases and four domestic animal diseases that cause vesicular or ulcerative lesions indistinguishable from FMDV infection in cattle, sheep and swine. The FMDV 'look-alike' diagnostic assay panel contains five PCR and twelve reverse transcriptase PCR (RT-PCR) signatures for a total of seventeen simultaneous PCR amplifications for seven diseases plus incorporating four internal assay controls. It was developed and optimized to amplify both DNA and RNA viruses simultaneously in a single tube and employs Luminex{trademark} liquid array technology. Assay development including selection of appropriate controls, a comparison of signature performance in single and multiplex testing against target nucleic acids, as well of limits of detection for each of the individual signatures is presented. While this assay is a prototype and by no means a comprehensive test for FMDV 'look-alike' viruses, an assay of this type is envisioned to have benefit to a laboratory network in routine surveillance and possibly for post-outbreak proof of freedom from foot-and-mouth disease.

  8. Diagnostic evaluation of a multiplexed RT-PCR microsphere array assay for the detection of foot-and-mouth disease virus and look-alike disease viruses

    SciTech Connect (OSTI)

    Hindson, B J; Reid, S M; Baker, B R; Ebert, K; Ferris, N P; Bentley Tammero, L F; Lenhoff, R J; Naraghi-Arani, P; Vitalis, E A; Slezak, T R; Hullinger, P J; King, D P

    2007-07-26

    A high-throughput multiplexed assay was developed for the differential laboratory diagnosis of foot-and-mouth disease virus (FMDV) from viruses which cause clinically similar diseases of livestock. This assay simultaneously screens for five RNA and two DNA viruses using multiplexed reverse transcription PCR (mRT-PCR) amplification coupled with a microsphere hybridization array and flow-cytometric detection. Two of the seventeen primer-probe sets included in this multiplex assay were adopted from previously characterized real-time RT-PCR (rRT-PCR) assays for FMDV. The diagnostic accuracy of the mRT-PCR was evaluated using 287 field samples, including 248 (true positive n= 213, true negative n=34) from suspect cases of foot-and-mouth disease collected from 65 countries between 1965 and 2006 and 39 true negative samples collected from healthy animals. The mRT-PCR assay results were compared with two singleplex rRT-PCR assays, using virus isolation with antigen-ELISA as the reference method. The diagnostic sensitivity of the mRT-PCR assay for FMDV was 93.9% [95% C.I. 89.8-96.4%], compared to 98.1% [95% C.I. 95.3-99.3%] for the two singleplex rRT-PCR assays used in combination. In addition, the assay could reliably differentiate between FMDV and other vesicular viruses such as swine vesicular disease virus and vesicular exanthema of swine virus. Interestingly, the mRT-PCR detected parapoxvirus (n=2) and bovine viral diarrhea virus (n=2) in clinical samples, demonstrating the screening potential of this mRT-PCR assay to identify viruses in FMDV-negative material not previously recognized using focused single-target rRT-PCR assays.

  9. Disease-Modifying Pathways in Neurodegeneration Steven Finkbeiner,1,2,3 Ana Maria Cuervo,5 Richard I. Morimoto,6 and Paul J. Muchowski1,3,4

    E-Print Network [OSTI]

    Morimoto, Richard

    , such as Alzhei- mer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS, we describe genetic exper- iments in yeast that identified a potential disease-modifying pathwaySymposium Disease-Modifying Pathways in Neurodegeneration Steven Finkbeiner,1,2,3 Ana Maria Cuervo

  10. A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm

    SciTech Connect (OSTI)

    Aderem, Alan; Adkins, Joshua N.; Ansong, Charles; Galagan, James; Kaiser, Shari; Korth, Marcus J.; Law, G. L.; McDermott, Jason E.; Proll, Sean; Rosenberger, Carrie; Schoolnik, Gary; Katze, Michael G.

    2011-02-01

    The 20th century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and water borne illnesses are frequent, multi-drug resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past—including the intense focus on individual genes and proteins typical of molecular biology—have not been sufficient to address these challenges. The first decade of the 21st century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program we think that the time is at hand to redefine the pathogen-host research paradigm.

  11. Introduction to Focus Issue: Rhythms and Dynamic Transitions in Neurological Disease: Modeling, Computation, and Experiment

    SciTech Connect (OSTI)

    Kaper, Tasso J. Kramer, Mark A.; Rotstein, Horacio G.

    2013-12-15

    Rhythmic neuronal oscillations across a broad range of frequencies, as well as spatiotemporal phenomena, such as waves and bumps, have been observed in various areas of the brain and proposed as critical to brain function. While there is a long and distinguished history of studying rhythms in nerve cells and neuronal networks in healthy organisms, the association and analysis of rhythms to diseases are more recent developments. Indeed, it is now thought that certain aspects of diseases of the nervous system, such as epilepsy, schizophrenia, Parkinson's, and sleep disorders, are associated with transitions or disruptions of neurological rhythms. This focus issue brings together articles presenting modeling, computational, analytical, and experimental perspectives about rhythms and dynamic transitions between them that are associated to various diseases.

  12. Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington’s Disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Budworth, Helen; Harris, Faye R.; Williams, Paul; Lee, Do Yup; Holt, Amy; Pahnke, Jens; Szczesny, Bartosz; Acevedo-Torres, Karina; Ayala-Peña, Sylvette; McMurray, Cynthia T.; et al

    2015-08-06

    Huntington’s Disease (HD) is caused by inheritance of a single disease-length allele harboring an expanded CAG repeat, which continues to expand in somatic tissues with age. The inherited disease allele expresses a toxic protein, and whether further somatic expansion adds to toxicity is unknown. We have created an HD mouse model that resolves the effects of the inherited and somatic expansions. We show here that suppressing somatic expansion substantially delays the onset of disease in littermates that inherit the same disease-length allele. Furthermore, a pharmacological inhibitor, XJB-5-131, inhibits the lengthening of the repeat tracks, and correlates with rescue of motormore »decline in these animals. The results provide evidence that pharmacological approaches to offset disease progression are possible.« less

  13. Development of a Vaccine for Bacterial Kidney Disease in Salmon, 1987 Annual Report.

    SciTech Connect (OSTI)

    Kaattari, Stephen

    1988-06-01

    Bacterial kidney disease (BKD) has been and remains a chronic contributory problem limiting the productivity of salmon in the Columbia River Basin. Control of this disease will not come easily, but it would lead to a tremendous increase in the health and numbers of salmon populations. Vaccination of salmon to Renibacterium salmoninarum (KDB) is a potentially successful method of controlling this disease. To date, however, no successful vaccine has been developed for general use. A possible solution to this problem, and thus the goal of this research, is to isolate the antigenic components of KDB and enhance their ability to activate the host defenses. This will be accomplished by the chemical modification of these antigens with potent immunomodulatory substances. These modified antigens will then be tested for their effectiveness in inducing immunity to BKD and thereby preventing the disease. The goal of the project's fourth year was to test the immunogenicity and prophylactic value in coho salmon (Oncorhynchus kisutch) of various--chemical conjugates of Renibacterium salmoninarum cell and major antigens. This was accomplished by assessing the serum antibody response, the cellular immune response (chemiluminescence), and the kinetics of mortality after lethal injections of the bacteria. The studies completed this year have: (1) identified immunization procedures which enhance the induction of high levels of antibody; (2) identified functionally distinct serum antibodies which may possess different abilities to protect salmon against BKD; (3) begun the isolation and characterization of anti-R. salmoninarum antibodies which may correlate with varying degrees of protection; (4) identified chemiluminescence as a potential method for assessing cellular immunity to bacterial kidney disease; and (5) characterized two monoclonal antibodies to R. salmoninarum which will be of benefit in the diagnosis of this disease.

  14. Serum Proteome Profiles in Stricturing Crohn’s Disease: A pilot study.

    SciTech Connect (OSTI)

    Townsend, Peter; Zhang, Qibin; Shapiro, Jason; Webb-Robertson, Bobbie-Jo M.; Bramer, Lisa M.; Schepmoes, Athena A.; Weitz, Karl K.; Mallette, Meaghan; Moniz, Heather; Bright, Renee; Merrick, Marjorie; Shah, Samir A.; Sands, Bruce E.; Leleiko, Neal

    2015-08-01

    Background: Crohn’s disease (CD) is a form of inflammatory bowel disease (IBD) with different described behaviors, including stricture. At present, there are no laboratory studies that can differentiate stricturing CD from other phenotypes of IBD. We performed a pilot study to examine differences in the proteome among patients with stricturing Crohn’s disease, non-stricturing Crohn’s disease, and ulcerative colitis (UC). Methods: Serum samples were selected from the Ocean State Crohn’s and Colitis Area Registry (OSCCAR), an established cohort of patients with IBD. Crohn’s disease patients with surgically-resected stricture were matched with similar patients with Crohn’s disease without known stricture, and with UC. Serum samples from each patient were digested and analyzed using liquid chromatography-mass spectrometry to characterize the proteome. Statistical analyses were performed to identify peptides and proteins that can differentiate CD with stricture. Results: Samples from 9 patients in each group (27 total patients) were analyzed. Baseline demographic characteristics were similar among the three groups. We quantified 7668 peptides and 897 proteins for analysis. ROC analysis identified a subset of peptides with an area under the curve greater than 0.9, indicating greater separation potential. Partial least squares discriminant analysis was able to distinguish among the three groups with up to 70% accuracy by peptides, and up to 80% accuracy by proteins. We identified the significantly different proteins and peptides, and determined their function based on previously published literature. Conclusions: The serum of patients with stricturing CD, non-stricturing CD, and UC are distinguishable via proteomic analysis. Some of the proteins that differentiate the stricturing phenotype have been implicated in complement activation, fibrinolytic pathways, and lymphocyte adhesion.

  15. Special Publication No. 2, A Bibliography On Chagas' Disease (1909-1969) 

    E-Print Network [OSTI]

    Olivier, Margaret C.; Olivier, Louis J.; Segal, Dorothy B.

    1972-01-01

    -Mazza en la Rep?blica Argentina. (National program for Chagas' disease control in Argentina.) Dia Med., Buenos Aires, 34(13): 277-278, Mar. 12. 1965,- New light on Chagas' disease. (Nuevas luces sobre la enfermedad de Chagas.) Lancet, 1:1150- 1151, May.... (Cardiomyopathies.) Bol. Ofic. San. Panamer., 61(5):452-460, Nov. Abalos, Jorge W. 1946,- Hallazgo de Panstrongylus megistus en la Argen- tina. (The collection of P^. megistus in Argentina.) An. Inst. Med. Reg., Tucum?n, 1(3): 333-335. 1958.- Importancia...

  16. Factors determining the progression of nonalcoholic fatty liver disease; the role of abnormal fatty acid and glucocorticoid metabolism 

    E-Print Network [OSTI]

    MacFarlane, David Peter

    2011-11-25

    Obesity and insulin resistance are associated with a constellation of features including hypertension, dyslipidaemia, type 2 diabetes, and premature cardiovascular disease, collectively termed the metabolic syndrome. ...

  17. Could mitochondrial efficiency explain the susceptibility to adiposity, metabolic syndrome, diabetes and cardiovascular diseases in South Asian populations? 

    E-Print Network [OSTI]

    Bhopal, Raj; Rafnsson, Snorri B

    2009-01-01

    Background South Asians are susceptible to cardiovascular disease (CVD), especially after migration to affluent countries. Contributing factors include high prevalence of diabetes, and possibly insulin resistance. Excess ...

  18. Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease.

    E-Print Network [OSTI]

    2007-01-01

    term potentiation by brain-derived neurotrophic factor. JNeurobiology of Disease Brain-Derived Neurotrophic Factorbe rescued with brain-derived neurotrophic factor (BDNF).

  19. * Corresponding author. : Primary student contributors. On Building a Quantitative Food-Disease-Gene Network

    E-Print Network [OSTI]

    Yang, Hui

    nutrients), diseases, and genes [16]. For instance, soy products and green tea have been two to the MEDLINE database on "soy and cancer" renders a total of 1,287 articles, and a search on "green tea: (1) given a pair of entities, e.g., green tea and cancer, different studies might report different

  20. Emerging and opportunistic diseases are caused by a microorganism invading a new

    E-Print Network [OSTI]

    Gomulkiewicz, Richard

    Emerging and opportunistic diseases are caused by a microorganism invading a new habitat, either meningitis). Often, the pathogen can live for many generations in the new habitat and, as natural selection be applied to most bacterial pathogens and suggest a phylogeny-based method to search for genes undergoing

  1. Sustainable vector control and management of Chagas disease in the Gran Chaco, Argentina

    E-Print Network [OSTI]

    Cohen, Joel E.

    Sustainable vector control and management of Chagas disease in the Gran Chaco, Argentina Ricardo E Aires, Argentina; Department of Pathobiology and Center for Zoonoses Research, University of Illinois. Mario Fatala Chaben, Paseo Colo´ n 568, 1032 Buenos Aires, Argentina; and §Laboratory of Populations

  2. Modelling of Blood Diseases November 5-9, 2007, Lyon, France

    E-Print Network [OSTI]

    Maume-Deschamps, Véronique

    Workshop Modelling of Blood Diseases November 5-9, 2007, Lyon, France Scientific committee: M Lyon 1) G. Bricca (University Lyon 1) C. Dumontet (Hopital E. Herriot, University Lyon 1) E. Grenier (Ecole Normale Superieure de Lyon) J. Macgregor (Kings College, University of London) C. Negrier (Hopital

  3. Streptomyces competition and co-evolution in relation to plant disease suppression

    E-Print Network [OSTI]

    Thomas, David D.

    of secondary metabolite production among Streptomyces is due in part to genomic structure, with abundantStreptomyces competition and co-evolution in relation to plant disease suppression Linda L. Kinkel a,*, Daniel C. Schlatter a , Matthew G. Bakker b , Brett E. Arenz a a Department of Plant Pathology

  4. Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease,

    E-Print Network [OSTI]

    Nyholt, Dale R.

    proportion of total variation tagged by all SNPs was 0.26 (SE 0.04) for ED, 0.24 (SE 0.03) for AD and 0 that a substantial proportion of variation in liability is explained by common SNPs, and thereby give insightsEstimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease

  5. GENERAL TECHNICAL REPORT PSW-GTR-240 Operational Disease Screening Program for

    E-Print Network [OSTI]

    of koa wilt/dieback disease across the four main Hawaiian Islands: Kauai, Maui, Oahu, and Hawaii (fig. 2 to Wilt in Acacia koa in Hawaii1 Nick Dudley,2 Robert James,3 Richard Sniezko,4 Phil Cannon,5 Aileen Yeh,2 Tyler Jones,2 and Michael Kaufmann2 Introduction In Hawaii, koa (Acacia koa A. Gray) is a valuable tree

  6. Climate Change and Plant Diseases: Forests, Crops, and Food Katherine Siegel '13 and Priyan Wickremesinghe `13

    E-Print Network [OSTI]

    Smith, Kate

    services including water supply, climate regulation, and erosion control. Plant health is essential forest plants, such as chestnut blight and Dutch elm disease, reduce the production of ecosystem services, which may alter our ability to feed the human population by causing droughts, floods, and an increase

  7. The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination

    E-Print Network [OSTI]

    Wolgemuth, Charles

    The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through encounter in vivo. Here we show that the motility of Borrelia in gelatin ma- trices in vitro resembles and the rheological proper- ties of the gelatin, which cannot be accounted for by recent the- oretical predictions

  8. Age-Dependent Sex Bias in Clinical Malarial Disease in Hypoendemic Regions

    E-Print Network [OSTI]

    Sharma, Shobhona

    of Fundamental Research, Mumbai, India, 2 Department of Clinical Pharmacology, Seth GS Medical College, KEM Hospital, Mumbai, India, 3 Kasturba Hospital for Infectious Diseases, Mumbai, India, 4 National Institute datasets (2000­2009) were captured for the hypoendemic Mumbai region in Western India. To validate findings

  9. ARTICLE IN PRESS 3 Mapping cortical change in Alzheimer's disease, brain development,

    E-Print Network [OSTI]

    Thompson, Paul

    's disease, schizo- 19 phrenia, normal aging, and abnormal brain development based on 20 imaging data, not seen in individual brain scans, often emerge when 45population-based brain data are averaged School of Medicine, Los Angeles, CA 90095-1769, United States 9 b Child Psychiatry Branch, NIMH, Bethesda

  10. Plant Disease / March 1999 279 The Relationship of Gin Date to Aflatoxin Contamination of Cottonseed

    E-Print Network [OSTI]

    Cotty, Peter J.

    Plant Disease / March 1999 279 The Relationship of Gin Date to Aflatoxin Contamination crops and is frequently, as with cottonseed, the primary cause of aflatoxin contamination (13). When. Irrigation can influence aflatoxin contamination, par- ticularly if continued into the harvest sea- son (19

  11. Implementation Guide for use with 10 CFR Part 850, Chronic Beryllium Disease Prevention Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-01-04

    The Department of Energy (DOE) has established regulatory requirements for the Chronic Beryllium Disease Prevention Program (CBDPP) in Title 10 of the Code of Federal Regulations (CFR), Part 850 (10 CFR 850) [64 Federal Register (FR) 68854]. Supersedes DOE G 440.1-7. Certified 9-23-10.

  12. Protein Folding and Misfolding in Disease Instructors: Jean Baum and Ron Levy

    E-Print Network [OSTI]

    Chen, Kuang-Yu

    Protein Folding and Misfolding in Disease Instructors: Jean Baum and Ron Levy Tuesday 2:30-5:00 PDB Training Room Syllabus Part I: Protein Folding 9/4: Introduction to Protein Architecture 9/11: Cooperative Transitions in Protein Molecules 9/16: Kinetics of Protein Folding and the Energy Landscape Model 9

  13. South Carolina Pest Management Handbook for Field Crops -2015 COTTON DISEASE CONTROL

    E-Print Network [OSTI]

    Stuart, Steven J.

    South Carolina Pest Management Handbook for Field Crops - 2015 111 COTTON DISEASE CONTROL John D the label. Do not use treated seed for feed or food. #12;South Carolina Pest Management Handbook for Field by commercial seed treaters. #12;South Carolina Pest Management Handbook for Field Crops - 2015 113 AVAILABLE

  14. U.S. Department of Health and Human Services Centers for Disease Control and Prevention

    E-Print Network [OSTI]

    's Global Water, Sanitation, and Hygiene (WASH) Program CS216950-A Water is considered to be the most, including population growth, rapid urbanization, land use, industrial discharge of chemicals, and factors of drinking water,3 leaving them at risk for water-, sanitation-, and hygiene- (WASH) related diseases

  15. Identification of genetic influences in late-onset Alzheimer’s disease (LOAD) 

    E-Print Network [OSTI]

    Allen, Mariet

    2011-11-25

    Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia, with an incidence of up to 50% in western populations over the age of 85 and a high heritability (up to 80%). The identification of risk factors ...

  16. Can Tau-guided auditory cues help control of movement in Parkinson's Disease patients ? 

    E-Print Network [OSTI]

    Curran, Isabel

    2006-01-01

    Based on the theory that the movement disturbances seen in Parkinson’s disease are caused by the lack of an intrinsic tau-guide (Lee et al, 1999), and drawing from knowledge of the role of the basal ganglia and its ...

  17. NUTRITIONAL STATUS AND CLINICAL OUTCOME IN POST-TERM NEONATES UNDERGOING SURGERY FOR CONGENITAL HEART DISEASE

    E-Print Network [OSTI]

    Mitting, Rebecca; Marino, Luise; Macrae, Duncan; Shastri, Nitin; Meyer, Rosan; Pathan, Nazima

    2015-06-01

    49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 REFERENCES: 1. Hoffman JI, Kaplan S: The incidence of congenital heart disease. Journal of the American College of Cardiology 2002, 39(12):1890-1900. 2. Thommessen M, Heiberg A...

  18. "America? A disease in people's minds!" Portugal and the propaganda of emigration

    E-Print Network [OSTI]

    Oxford, University of

    after 21 St Giles) In this seminar award-winning documentary film maker and researcher, Jacinto Godinho presentation by Dr Godinho, the screening of a specially made documentary "`America? A disease in people National Television Network. He is the director of a fascinating (and award winning) documentary series

  19. In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

    E-Print Network [OSTI]

    Hebert, Daniel N.

    In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases 1377 C. Protein folding 1378 II. Protein Translocation, Folding, and Quality Control in the Endoplasmic Reticulum 1379 A. Protein targeting to the ER 1379 B. Chaperone-assisted protein folding in the ER 1379 C

  20. ABSTRACT Genomics and bioinformatics have the vast potential to identify genes that cause disease by investigating

    E-Print Network [OSTI]

    Hammock, Bruce D.

    ABSTRACT Genomics and bioinformatics have the vast potential to identify genes that cause disease by investigating whole-genome databases. Comparison of an individual's geno- type with a genomic database these metabolic profiles with genomic, expression, and proteomic databases. Application of the knowledge of indi