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Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Classification and Localisation of Diabetic-Related Eye Disease  

Science Conference Proceedings (OSTI)

Retinal exudates are a characteristic feature of many retinal diseases such as Diabetic Retinopathy. We address the development of a method to quantitatively diagnose these random yellow patches in colour retinal images automatically. After a colour ...

Alireza Osareh; Majid Mirmehdi; Barry T. Thomas; Richard Markham

2002-05-01T23:59:59.000Z

2

Piercing ear cartilage  

NLE Websites -- All DOE Office Websites (Extended Search)

Piercing ear cartilage Piercing ear cartilage Name: Mark Reynolds Status: N/A Age: N/A Location: N/A Country: N/A Date: N/A Question: My name is Mark Reynolds. I have heard that there is a nerve in the cartilage area of the ear. My question is as follows: If you pierce your ear(s) and do hit the nerve, could permanent paralysis or brain damage occur? Thank you. Replies: No. Basically nerves serve two purposes: gathering information from the senses (sensory nerves) and controlling muscles (motor nerves). If you damage a sensory nerve, then that nerve can't send messages to the brain, but this will not damage the brain. If you damage a motor nerve then the brain can't send messages to a muscle and indeed paralysis occurs. But nerves are laid out sensibly, that is, nerves do not go from your brain through your earlobe and then on to your leg or arm. Damaging a motor nerve in your ear won't affect anything other than your ear muscles, if there are any. Paralysis is usually temporary if motor nerve damage occurs outside of the spinal cord, since the main body of the motor nerve cells are in the spinal cord and the "axons" connecting them to the muscles can regrow (about a millimeter a day). If nerve cell bodies themselves are damaged by injury to the spinal cord they may recover and paralysis go away. This may also happen even if nerve cells are killed, as long as not too many are, and other cells can take over. But if too many are killed paralysis is permanent, since nerve cells never reproduce.

3

Digital ear scanner : measuring the compliance of the ear  

E-Print Network (OSTI)

This paper seeks to resolve the biggest problem with hearing aids, their physical fit. By digitally scanning the ear canal and taking the dynamics of the ear into account the performance and comfort of a hearing aid can ...

Hernandez-Stewart, Daniel

2010-01-01T23:59:59.000Z

4

Glowing eyes  

NLE Websites -- All DOE Office Websites (Extended Search)

Glowing eyes Glowing eyes Name: Sophie Hunt Age: N/A Location: N/A Country: N/A Date: N/A Question: Why do dogs eyes glow in the dark? Replies: They have a reflective surface behind the retina (light sensitive back surface) of the eye which bounces light from, for example, your headlights back at you somewhat like highway reflectors. The purpose of the surface is to increase the ability of the retina to detect faint light -- that is, the ability of the animal to see in the dark -- by making the light pass *twice* through the retina. Humans don't have this surface, but very bright light will bounce back from the retina itself enough to be seen. Since the retina is red (from its ample blood supply) you see a red reflection, and this is the source of the "red spot" in the eyes in photographs of people who looked at the flash.

5

Eye Physiology  

NLE Websites -- All DOE Office Websites (Extended Search)

Eye Physiology Eye Physiology Name: Charlotte Location: N/A Country: N/A Date: N/A Question: I do Physics A level and in my last exam it was really annoying because one of the questions was something that I've always wanted to know but never got around to finding out. You know when you look at a star in the sky or those glowing stars that you stick on your bedroom ceiling? Well, why is it that they don't look as bright when you look directly at them, but do when you look slightly to the side? Replies: _Hello Charlotte The answer is to do with the biology of the eye. There are two types of receptor cells in the eye and each has strengths and weaknesses: 1. Rod cells - only see black and white but are very sensitive (ie will pick up very small amounts of light) 2. Cone cells - see color but are not as sensitive as rod cells.

6

black ears to blonde cats  

E-Print Network (OSTI)

black ears to blonde cats: paths for designing change Ben Bederson & Allison Druin Computer Science of cats lived in a remote village. A river divided the village in two. Black cats lived on one bank and blonde cats lived on the other... In summer and autumn, a black cat ruled the village and in spring

Golbeck, Jennifer

7

Eyes of Animals  

NLE Websites -- All DOE Office Websites (Extended Search)

"simple" eyes for close vision. Birds have the keenest eyes and those of the hawks, eagles and vultures can see small objects at incredible distances. By their eyes ye shall...

8

On guided model-based analysis for ear biometrics  

Science Conference Proceedings (OSTI)

Ears are a new biometric with a major advantage in that they appear to maintain their structure with increasing age. Current approaches have exploited 2D and 3D images of the ear in human identification. Contending that the ear is mainly a planar shape ... Keywords: Biometrics, Ear biometrics, Ear embryology, Model-based analysis, Occlusion analysis

Banafshe Arbab-Zavar; Mark S. Nixon

2011-04-01T23:59:59.000Z

9

Regional companies eye growth  

NLE Websites -- All DOE Office Websites (Extended Search)

Regional companies eye growth Regional companies eye growth Adaptive Radio Technologies, Los Alamos Visualization Associates, Mesa Tech International Inc., and ThermaSun Inc. were...

10

EAR ROT IN THE 2006 CORN CROP  

E-Print Network (OSTI)

Several incidences of ear rot have been noticed across Illinois and Iowa this year. In most cases, these fields were grown to corn the previous year. It is not surprising that ear rots are developing this year, given the late summer rains and high amount of stalk rots. Growers should be alerted to

unknown authors

2006-01-01T23:59:59.000Z

11

THE BLACK-EARED MINER A DECADE OF RECOVERY  

E-Print Network (OSTI)

THE BLACK-EARED MINER A DECADE OF RECOVERY David Baker-Gabb 2007 #12;Copyright © 2007. All or otherwise without prior written permission. The Black-eared Miner. A Decade of Recovery. © 2007 Black-eared Miner Recovery Team. Recommended citation: Baker-Gabb, D. (2007). The Black-eared Miner. A Decade

Frappell, Peter

12

Eye Color in Humans  

NLE Websites -- All DOE Office Websites (Extended Search)

Eye Color in Humans Eye Color in Humans Name: Kristi Location: N/A Country: N/A Date: N/A Question: The dominant characteristic is the one most likely to appear in the offspring. In human beings, brown is the dominant color for eyes. The children who inherit at least on dominant gene will have either brown, green, or hazel eyes. Only childten who inherit two recessive genes will have pure blue eyes. If there are eight children in the family, what color eyes will most of them have? Replies: http://www.newton.dep.anl.gov/archive.htm Search under eye color Steve Sample You answer is of course dependent on the genes of the parents. If both parents do not have the recessive gene, then no children will have light colored eyes. If one has a recessive gene and the other not, then still no children will have light color eyes and on the average 25% of the eight children could have the recessive gene. If both parents have the recessive gene, then 25% of the eight children could have light color eyes.

13

Tropical Cyclone Eye Dynamics  

Science Conference Proceedings (OSTI)

A new perspective of the dynamics of a tropical cyclone eye is given in which eye subsidence and the adiabatic warming accompanying it are accounted for directly from the equations of motion. Subsidence is driven by an adverse, axial gradient of ...

R. K. Smith

1980-06-01T23:59:59.000Z

14

Blue-eyed Babies  

NLE Websites -- All DOE Office Websites (Extended Search)

Blue-eyed Babies Blue-eyed Babies Name: Jill Location: N/A Country: N/A Date: N/A Question: One of my students asked me the other day why all babies are born with blue eyes, even though they are truly brown-eyed, once their eyes change colour. What causes this phenomenon? Exposure to air, maybe? Replies: Hi, First of all not all babies are born with blue eyes. This is especially evident in the Asian/ Indian continents. The cause for the delay is nothing more than a delay in the enzymes that bring on the darker color proteins. You are probably aware that eye color is determined by more than one gene. The darker colors have blue coloration as part of their make-up and that may be the only protein of the color exposed at birth for many individuals. The proteins that give the darker colors usually turn on within a year of birth and this timing varies with individuals.

15

Eye to I  

E-Print Network (OSTI)

This is the story of the language of eyes - what they say about our emotions, what they reveal about our intentions, how they interact with our face, and how they connect us to one another. The story follows our experience ...

Brunstein, Ada

2007-01-01T23:59:59.000Z

16

Glowing cat eyes  

NLE Websites -- All DOE Office Websites (Extended Search)

Referencing NEWTON About NEWTON About Ask A Scientist Education At Argonne Glowing cat eyes Name: Pamela A McDermott Location: NA Country: NA Date: NA Question: Why do...

17

Neurosensory Development in the Zebrafish Inner Ear  

E-Print Network (OSTI)

The vertebrate inner ear is a complex structure responsible for hearing and balance. The inner ear houses sensory epithelia composed of mechanosensory hair cells and non-sensory support cells. Hair cells synapse with neurons of the VIIIth cranial ganglion, the statoacoustic ganglion (SAG), and transmit sensory information to the hindbrain. This dissertation focuses on the development and regulation of both sensory and neuronal cell populations. The sensory epithelium is established by the basic helixloop- helix transcription factor Atoh1. Misexpression of atoh1a in zebrafish results in induction of ectopic sensory epithelia albeit in limited regions of the inner ear. We show that sensory competence of the inner ear can be enhanced by co-activation of fgf8/3 or sox2, genes that normally act in concert with atoh1a. The developing sensory epithelia express several factors that regulate differentiation and maintenance of hair cells. We show that pax5 is differentially expressed in the anterior utricular macula (sensory epithelium). Knockdown of pax5 function results in utricular hair cell death and subsequent loss of vestibular (balance) but not auditory (hearing) defects. SAG neurons are formed normally in these embryos but show disorganized dendrites in the utricle following loss of hair cells. Lastly, we examine the development of SAG. SAG precursors (neuroblasts) are formed in the floor of the ear by another basic helix-loophelix transcription factor neurogenin1 (neurog1). We show that Fgf emanating from the utricular macula specifies neuroblasts, that later delaminate from the otic floor and undergo a phase of proliferation. Neuroblasts then differentiate into bipolar neurons that extend processes to hair cells and targets in the hindbrain. We show evidence that differentiating neurons express fgf5 and regulate further development of the SAG. As more differentiated neurons accumulate, increasing level of Fgf terminates the phase of neuroblast specification. Later on, elevated Fgf stabilizes the transit-amplifying phase and inhibits terminal differentiation. Thus, Fgf signaling regulates SAG development at various stages to ensure that proper number of neurons is generated.

Vemaraju, Shruti

2011-12-01T23:59:59.000Z

18

Tropical Cyclone Eye Thermodynamics  

Science Conference Proceedings (OSTI)

In intense tropical cyclones, sea level pressures at the center are 50100 hPa lower than outside the vortex, but only 1030 hPa of the total pressure fall occurs inside the eye between the eyewall and the center. Warming by dry subsidence ...

H. E. Willoughby

1998-12-01T23:59:59.000Z

19

A library of eyes in Go II: Monolithic eyes  

E-Print Network (OSTI)

of eyes of larger sizes. · The number of positions grows only little by adding white throw-in stones of unusual positions in Go as done in the second half of the paper. 1 Introduction In using principles to eyes in order to decide whether a position lives unconditionally, simply by adding these values

Wolf, Thomas

20

Energy Eye | Open Energy Information  

Open Energy Info (EERE)

Eye Eye Jump to: navigation, search Name Energy Eye Address 13367 Kirkham Way Place San Diego, California Zip 92064 Sector Energy Efficiency Product Manufactures wireless devices that monitor room occupancy for energy conservation Website http://www.energy-eye.com/ Coordinates 32.899939°, -117.188214° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":32.899939,"lon":-117.188214,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Money for the big eyes  

E-Print Network (OSTI)

Since ancient civilization, humanity has kept its eyes on the heavens, and the invention of telescopes has only increased its scrutiny. As astronomers strive to see the universe with increasing clarity, telescopes have ...

Shen, Fangfei, S.M. Massachusetts Institute of Technology

2012-01-01T23:59:59.000Z

22

Effect of Annealing Condition on Earing and Texture Formation in ...  

Science Conference Proceedings (OSTI)

At low heating rate (0.01-1K/s) the ears on drawn cup situated at 45 deg. to the sheet rolling .... Corrosion Performance of New Generation Aluminum-Lithium Alloys for .... Increased Production and Quality with Reduced Operating Costs and...

23

EYE STRAIN AND EYE PROTECTION DURING IRRADIATION THERAPY AND DIAGNOSIS  

SciTech Connect

Sensitivity of various components of the eye is surveyed and means for preventing injury to them discussed. Pertinent experiments by the author on rabbits are described. The lens is the most radiation-sensitive part of the eye; two dependent changes take place after irradiation: clouding, and weight alterations of the lens. Cataract starts as a clouding of the posterior commissure, extends into the capsule, and it high doses there may- be clouding of the entire lens. Once clouding of the lens has begun it does not disappear. The threshold dose producing cataracts in young animals is about 200 r. Weight alterations of the lens, due to changes in water content or possibly growth inhibition or destructive changes, appear at doses far below those needed to produce clouding. The threshold dose for clouding of the cornea is about 10 times that for the lens. Doses in excess of 2000 r result in corneal clouding in 70% of the cases, but are reversible. The conjunctiva is also relatively insensitive to irradiation. When the eyes of young animals are irradiated, development of the whole eye is retarded. A 12% reduction in the weight of the eye follows absorption of 1000 rad, and this rises to 40% at 2000 rad. The RBE of different forms of radiation on damage to the lens is tabulated. Effects of radiation on the eye vary directly with the dose absorbed, and inversely with the age of the animal at the time or irradiation, both of which reduce the time of onset and intensity of manifestations. Age determines both the latent period before onset of symptoms, and the time to develop full damage. Radiation injury occurs in four stages that are identified. Any necessary xray examinations of the eye may be undertaken and repeated when required, without fear of complications, as no methods of x-ray diagnosis give a surface dose approaching 200 r, but caution is required in therapeutic irradiation of the head region. The radiation dose at the lens during treatment of tumors of the antra, orbits, nasopharynx and palate, and of the brain show that the threshold dose for irradiation cataract is exceeded by some methods. Also discussed is the extent to which the eyes of a radiologist in a diagnostic department are endangered by radiation exposure. (BBB)

Krokowski, E.

1963-10-01T23:59:59.000Z

24

More Than Meets the Eye  

NLE Websites -- All DOE Office Websites (Extended Search)

More Than Meets the Eye Jefferson Lab invites you on a journey into the realm of the unseen. Join us as we explain how scientists use our facility to learn more about the world's smallest particle _ the quark. Narrative poem and storyboard by: John Anderson II Illustrations and design by: John Thomas Answers to word find on last page. QUARKS: More Than Meets the Eye The sun, the moon, the galaxy and every single star, consist of tiny particles that make up who we are. These particles are everywhere, in everything around.

25

Curbing bully new eye exam  

E-Print Network (OSTI)

CTriCiTy DawnStudying the geology of giant asteroids to reveal the secrets of our solar system #12;Jimmy G to the dawning of our solar system. Page 18 What does "Supply Chain" really mean? Page 14 Genetically engineering to supply chain management than meets the eye Revealing Secrets of Our Solar System 18 Hap McSween studies

Tennessee, University of

26

Eye movement studies with a vestibular prosthesis/  

E-Print Network (OSTI)

Vestibular loss, which can manifest as dizziness, imbalance, or spatial disorientation, is widespread and often caused by inner ear hair cell malfunction. To address these problems, we are developing a vestibular implant ...

Saginaw, Michael A. (Michael Adlai)

2010-01-01T23:59:59.000Z

27

PAPILLON: expressive eyes for interactive characters  

Science Conference Proceedings (OSTI)

PAPILLON is a technology for designing highly expressive animated eyes for interactive characters, robots and toys. Expressive eyes are essential in any form of face-to-face communication [2] and designing them has been a critical challenge in ...

Eric Brockmeyer; Ivan Poupyrev; Moshe Mahler; Joanne Dauner; James Krahe

2013-07-01T23:59:59.000Z

28

Modernizing the handling of ear corn. Final technical report  

DOE Green Energy (OSTI)

The goal of the project was to modernize the handling of ear corn. The corn was picked with a three row JD 300 picker pulled by a tractor. Pulled behind the picker was a side dump wagon with a capacity of 150 bushels of ear corn. When the dump wagon was full, a grain truck was driven along side of the wagon and the dump wagon, controlled by the tractor driver, was emptied into the truck. After two dumps of the wagon, the truck was driven to the storage area. The storage area consisted of ten (ten) 2000 bushel corn cribs set in a semi circle so that the elevator that filled the cribs could be moved from one crib to the next without changing the fill point. At the storage area, the truck full of corn was dumped into the platform feeder. By using a platform feeder to feed the elevator, all ten (10) cribs could be filled without moving it. After the harvest was complete, the corn remains in the cribs until needed for feed or until the corn is sold. During the time that the corn remains in the cribs, the turbine ventilator draws air through the corn and dries it.

Kleptz, C.F.

1980-01-01T23:59:59.000Z

29

Challenges in the design of a GNSS ear tag for feedlot cattle  

Science Conference Proceedings (OSTI)

A Global Navigation Satellite System (GNSS) based ear tag was designed developed and tested for use on cattle in feedlots. Previous research by others has primarily used GNSS collars; however the widespread use of a Position, Velocity and Time (PVT) ... Keywords: Ear tag, Feedlot, GNSS, GPS, Livestock health, Low-power, Wireless sensor network

J. B. Schleppe; G. Lachapelle; C. W. Booker; T. Pittman

2010-01-01T23:59:59.000Z

30

Systems and methods for biometric identification using the acoustic properties of the ear canal  

DOE Patents (OSTI)

The present invention teaches systems and methods for verifying or recognizing a person's identity based on measurements of the acoustic response of the individual's ear canal. The system comprises an acoustic emission device, which emits an acoustic source signal s(t), designated by a computer, into the ear canal of an individual, and an acoustic response detection device, which detects the acoustic response signal f(t). A computer digitizes the response (detected) signal f(t) and stores the data. Computer-implemented algorithms analyze the response signal f(t) to produce ear-canal feature data. The ear-canal feature data obtained during enrollment is stored on the computer, or some other recording medium, to compare the enrollment data with ear-canal feature data produced in a subsequent access attempt, to determine if the individual has previously been enrolled. The system can also be adapted for remote access applications.

Bouchard, Ann Marie (Albuquerque, NM); Osbourn, Gordon Cecil (Albuquerque, NM)

1998-01-01T23:59:59.000Z

31

Auditory system comparisons between sand cats and other felid species : acoustic input admittance of ears and auditory brainstem responses  

E-Print Network (OSTI)

The sand cat, one species of the cat family, is found only in deserts and has unusually large ear canals and middle-ear air cavities. Recent work has shown that sand cat ears absorb acoustic power at low frequencies (<1 ...

Chan, Howard F

2005-01-01T23:59:59.000Z

32

Comparative approaches to otoacoustic emissions : towards and understanding of why the ear emits sound  

E-Print Network (OSTI)

The ear represents a remarkable achievement in sensory physiology. It is very fast (timescales on the order of 1-100 kHz), has a large bandwidth (-10 octaves in the human), highly sensitive (threshold is ultimately determined ...

Bergevin, Christopher

2007-01-01T23:59:59.000Z

33

Photo of the Week: Eye-to-Eye with a Wind Turbine | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Eye-to-Eye with a Wind Turbine Eye-to-Eye with a Wind Turbine Photo of the Week: Eye-to-Eye with a Wind Turbine August 7, 2013 - 10:35am Addthis At the National Renewables Energy Laboratory (NREL), scientists use the Insight Center Collaboration Room to examine and interact with their data. In this simulation, the room is converted into a virtual wind tunnel, allowing scientists to study the complex, turbulent flow fields around wind turbines. Pictured here, NREL Senior Scientist Kenny Gruchalla examines the velocity field surrounding a wind turbine, using a 3-D model projected onto the center's 16-by-8 foot wall. The simulation helps scientists better understand flow patterns, and further, how turbines can better avoid gearbox failures. Learn more about the Insight Center Collaboration Room. | Photo courtesy of Dennis Schroeder, NREL.

34

EyeOn Solar | Open Energy Information  

Open Energy Info (EERE)

EyeOn Solar EyeOn Solar Jump to: navigation, search Name EyeOn Solar Place Boulder, Colorado Zip 80304 Sector Renewable Energy, Solar Product EyeOn Solar develops, owns and operates renewable energy assets in the state of Colorado. Coordinates 42.74962°, -109.714163° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":42.74962,"lon":-109.714163,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

35

Video Games: A Site for Sore Eyes  

E-Print Network (OSTI)

1984). Rx for lazy eye: Video game exercise. Science News,patients. Here we have seen video games used for amblyopia,function through action video game training. Nature

Mozaffari, Sahar

2011-01-01T23:59:59.000Z

36

Data eye monitor method and apparatus  

DOE Patents (OSTI)

An apparatus and method for providing a data eye monitor. The data eye monitor apparatus utilizes an inverter/latch string circuit and a set of latches to save the data eye for providing an infinite persistent data eye. In operation, incoming read data signals are adjusted in the first stage individually and latched to provide the read data to the requesting unit. The data is also simultaneously fed into a balanced XOR tree to combine the transitions of all incoming read data signals into a single signal. This signal is passed along a delay chain and tapped at constant intervals. The tap points are fed into latches, capturing the transitions at a delay element interval resolution. Using XORs, differences between adjacent taps and therefore transitions are detected. The eye is defined by segments that show no transitions over a series of samples. The eye size and position can be used to readjust the delay of incoming signals and/or to control environment parameters like voltage, clock speed and temperature.

Gara, Alan G. (Mount Kisco, NY); Marcella, James A. (Rochester, MN); Ohmacht, Martin (Yorktown Heights, NY)

2012-01-31T23:59:59.000Z

37

A photon accurate model of the human eye  

Science Conference Proceedings (OSTI)

A photon accurate model of individual cones in the human eye perceiving images on digital display devices is presented. Playback of streams of pixel video data is modeled as individual photon emission events from within the physical substructure of each ... Keywords: display devices, eye models, human eye cone models, schematic eyes, synthesized retina

Michael F. Deering

2005-07-01T23:59:59.000Z

38

Do-It-yourself eye tracker: low-cost pupil-based eye tracker for computer graphics applications  

Science Conference Proceedings (OSTI)

Eye tracking technologies offer sophisticated methods for capturing humans' gaze direction but their popularity in multimedia and computer graphics systems is still low. One of the main reasons for this are the high cost of commercial eye trackers that ... Keywords: computer graphics, eye tracker accuracy, eye tracking, human computer interfaces

Rados?aw Mantiuk; Micha? Kowalik; Adam Nowosielski; Bartosz Bazyluk

2012-01-01T23:59:59.000Z

39

Proactive Information Retrieval by Monitoring Eye Movements  

E-Print Network (OSTI)

A long term goal in user modeling for improving human-computer interaction is to understand the user's intent based on her monitored actions. We are developing an information retrieval system where the task is to predict relevance for new documents, given judgments on old ones. By monitoring the user's eye movements and inferring implicit feedback from them we reduce the amount of tedious ranking of retrieved documents, called relevance feedback in standard information retrieval. Relevance is inferred with machine learning methods, trained on eye movement patterns measured in settings where relevance is known. Noise in the predictions is compensated for by fusing the eye movements with other information about the user's preferences. The goal is to make the information retrieval system proactive, that is, capable of anticipating the user's interests.

Samuel Kaski

2005-01-01T23:59:59.000Z

40

Cyclorotation models for eyes and cameras  

Science Conference Proceedings (OSTI)

The human visual system obeys Listing's law, which means that the cyclorotation of the eye (around the line of sight) can be predicted from the direction of the fixation point. It is shown here that Listing's law can conveniently be formulated in terms ... Keywords: biological control systems, robot kinematics, visual system

Miles Hansard; Radu Horaud

2010-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Virginia big-eared bats (Corynorhinus townsendii virginianus) roosting in abandoned coal mines in West Virginia  

Science Conference Proceedings (OSTI)

We surveyed bats at 36 abandoned coal mines during summer 2002 and 47 mines during fall 2002 at New River Gorge National River and Gauley River National Recreation Area, WV. During summer, we captured three federally endangered Virginia big-eared bats at two mine entrances, and 25 were captured at 12 mine entrances during fall. These represent the first documented captures of this species at coal mines in West Virginia. Future survey efforts conducted throughout the range of the Virginia big-eared bat should include abandoned coal mines.

Johnson, J.B.; Edwards, J.W.; Wood, P.B. [West Virginia University, Morgantown, WV (US). Wildlife & Fisheries Resources Programme

2005-07-01T23:59:59.000Z

42

An Algorithm for Tracking Eyes of Tropical Cyclones  

Science Conference Proceedings (OSTI)

A tropical cyclone (TC) eye tracking (TCET) algorithm is presented in this study to objectively identify and track the eye and center of a tropical cyclone using radar reflectivity data. Twelve typhoon cases were studied for evaluating the TCET ...

Pao-Liang Chang; Ben Jong-Dao Jou; Jian Zhang

2009-02-01T23:59:59.000Z

43

Tropical cyclone eye fix using genetic algorithm with temporal information  

Science Conference Proceedings (OSTI)

Tropical cyclones (TCs) are weather systems with vast destructive power. To give early TC warnings, accurate location of their circulation centers, or eyes, is required. The pattern matching solution to this TC eye fix problem works by ...

Ka Yan Wong; Chi Lap Yip

2005-09-01T23:59:59.000Z

44

Automatic tropical cyclone eye fix using genetic algorithm  

Science Conference Proceedings (OSTI)

Tropical cyclones (TCs) are weather systems with vast destructive power. To forecast TC tracks, forecasters need to locate their circulation centers, or eyes. This eye fix process is often done manually in practice. Since subjective elements are involved ... Keywords: Genetic algorithm, Meteorological computing, Tropical cyclone eye fix, Weather forecasting, Weather system modeling

Ka Yan Wong; Chi Lap Yip; Ping Wah Li

2008-01-01T23:59:59.000Z

45

Measuring gaze depth with an eye tracker during stereoscopic display  

Science Conference Proceedings (OSTI)

While determining 2D gaze position using eye tracking is common practice, the efficacy of using eye tracking to measure 3D gaze point in a stereoscopic display has not been carefully studied. In this paper we explore this issue using a custom Wheatstone ... Keywords: eye tracking, stereoscope, stereoscopic rendering

Andrew T. Duchowski; Brandon Pelfrey; Donald H. House; Rui Wang

2011-08-01T23:59:59.000Z

46

Does the infrasound from wind turbines affect the inner ear? Alec N. Salt1  

E-Print Network (OSTI)

Does the infrasound from wind turbines affect the inner ear? Alec N. Salt1 1 Washington University turbines adversely affects human health. The unweighted spectrum of wind turbine noise slowly rises (needing over 120 dB SPL to detect 2 Hz) it is claimed that infrasound generated by wind turbines is below

Salt, Alec N.

47

NETL: News Release - Eyes in the Sky...  

NLE Websites -- All DOE Office Websites (Extended Search)

August 28, 2003 August 28, 2003 Eyes in the Sky... Remote Sensing Technology Maps Flow of Groundwater from the Air Photo: Remote Sensor Suspended Beneath a Helicopter Detects Groundwater Beneath the Surface DOE is using remote sensors suspended from helicopters to map the flow of groundwater that may be affected by energy projects. In four states this past spring and summer, eyes have turned skyward as helicopters zig-zagged over hills and valleys, towing torpedo- or spiderweb-like contraptions that conjured up thoughts of Superman - "Look! Up in the sky!" But the "x-ray vision" in this case isn't comic-book fantasy. Instead, using aerial remote sensing techniques, researchers working with the U.S. Department of Energy are "seeing" through solid ground to create

48

Determination of positions of optical elements of the human eye  

Science Conference Proceedings (OSTI)

An original method for noninvasive determining the positions of elements of intraocular optics is proposed. The analytic dependence of the measurement error on the optical-scheme parameters and the restriction in distance from the element being measured are determined within the framework of the method proposed. It is shown that the method can be efficiently used for determining the position of elements in the classical Gullstrand eye model and personalised eye models. The positions of six optical surfaces of the Gullstrand eye model and four optical surfaces of the personalised eye model can be determined with an error of less than 0.25 mm. (human eye optics)

Galetskii, S O; Cherezova, T Yu [M. V. Lomonosov Moscow State University, Faculty of Physics, Moscow (Russian Federation)

2009-02-28T23:59:59.000Z

49

Intra- and interspecific responses to Rafinesques big-eared bat (Corynorhinus rafinesquii) social calls.  

SciTech Connect

Bats respond to the calls of conspecifics as well as to calls of other species; however, few studies have attempted to quantify these responses or understand the functions of these calls. We tested the response of Rafinesques big-eared bats (Corynorhinus rafinesquii) to social calls as a possible method to increase capture success and to understand the function of social calls. We also tested if calls of bats within the range of the previously designated subspecies differed, if the responses of Rafinesques big-eared bats varied with geographic origin of the calls, and if other species responded to the calls of C. rafinesquii. We recorded calls of Rafinesques big-eared bats at two colony roost sites in South Carolina, USA. Calls were recorded while bats were in the roosts and as they exited. Playback sequences for each site were created by copying typical pulses into the playback file. Two mist nets were placed approximately 50500 m from known roost sites; the net with the playback equipment served as the Experimental net and the one without the equipment served as the Control net. Call structures differed significantly between the Mountain and Coastal Plains populations with calls from the Mountains being of higher frequency and longer duration. Ten of 11 Rafinesques big-eared bats were caught in the Control nets and, 13 of 19 bats of other species were captured at Experimental nets even though overall bat activity did not differ significantly between Control and Experimental nets. Our results suggest that Rafinesques big-eared bats are not attracted to conspecifics calls and that these calls may act as an intraspecific spacing mechanism during foraging.

Loeb, Susan, C.; Britzke, Eric, R.

2010-07-01T23:59:59.000Z

50

A wearable heart monitor at the ear using ballistocardiogram (BCG) and electrocardiogram (ECG) with a nanowatt ECG heartbeat detection circuit  

E-Print Network (OSTI)

This work presents a wearable heart monitor at the ear that uses the ballistocardiogram (BCG) and the electrocardiogram (ECG) to extract heart rate, stroke volume, and pre-ejection period (PEP) for the application of ...

He, David Da

2013-01-01T23:59:59.000Z

51

Urban Eyes: Ultra-wideband (UWB) Detecting and Tracking  

California, Lawrence Livermore National Laboratory, under Contract No. W-7405-Eng-48. UCRL-PRES-217242 Urban Eyes is a man-portable micro-power

52

On global geometry of image on eye's back  

Science Conference Proceedings (OSTI)

We investigate the geometric properties of the global image that forms on the hemispheric back of the eye. Keywords: natural vision, visual cognition, visual perception

Paolo D 'Alessandro

2007-10-01T23:59:59.000Z

53

Eye gaze assistance for a game-like interactive task  

Science Conference Proceedings (OSTI)

Human beings communicate in abbreviated ways dependent on prior interactions and shared knowledge. Furthermore, humans share information about intentions and future actions using eye gaze. Among primates, humans are unique in the whiteness of the sclera ...

Tams D. Gedeon; Dingyun Zhu; B. Sumudu U. Mendis

2008-01-01T23:59:59.000Z

54

Use Of Green Porphyrinsto Treat Neovasculature In The Eyes  

DOE Patents (OSTI)

Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions.

Levy, Julia (Vancouver, CA); Miller, Joan W. (Boston, MA); Gradoudas, Evangelos S. (Boston, MA); Hasan, Tayyaba (Arlington, MA); Schmidt-Erfurth, Ursula (Luebeck, DE)

1998-08-25T23:59:59.000Z

55

Angiographic Method Using Green Porphyrinew In Primmate Eyes  

DOE Patents (OSTI)

An angiographic method to observe the condition of blood vessels, including neovasculature in the eyes of living primates using green porphyrins and light at a wavelength of 550-700 nm to effect fluorescence is disclosed.

Miller, Joan W. (Boston, MA); Young, Lucy H.Y. (Boston, MA); Gragoudas, Evangelos S. (Boston, MA)

1998-01-13T23:59:59.000Z

56

All Eyes on Eastport: Tidal Energy Project Brings Change, Opportunity...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Tidal Energy Project Brings Change, Opportunity to Local Community All Eyes on Eastport: Tidal Energy Project Brings Change, Opportunity to Local Community July 24, 2012 - 2:40pm...

57

Forces between clustered stereocilia minimize friction in the ear on a subnanometre scale  

E-Print Network (OSTI)

The detection of sound begins when energy derived from acoustic stimuli deflects the hair bundles atop hair cells. As hair bundles move, the viscous friction between stereocilia and the surrounding liquid poses a fundamental challenge to the ear's high sensitivity and sharp frequency selectivity. Part of the solution to this problem lies in the active process that uses energy for frequency-selective sound amplification. Here we demonstrate that a complementary part involves the fluid-structure interaction between the liquid within the hair bundle and the stereocilia. Using force measurement on a dynamically scaled model, finite-element analysis, analytical estimation of hydrodynamic forces, stochastic simulation and high-resolution interferometric measurement of hair bundles, we characterize the origin and magnitude of the forces between individual stereocilia during small hair-bundle deflections. We find that the close apposition of stereocilia effectively immobilizes the liquid between them, which reduces t...

Kozlov, Andrei S; Risler, Thomas; Versteegh, Corstiaen P C; Hudspeth, A J; 10.1038/nature10073

2012-01-01T23:59:59.000Z

58

Treatment and Prognosis of Squamous Cell Carcinoma of the External Auditory Canal and Middle Ear: A Multi-Institutional Retrospective Review of 87 Patients  

Science Conference Proceedings (OSTI)

Purpose: To examine the relative roles of surgery, radiotherapy, and chemotherapy in the management of patients with squamous cell carcinomas of the external auditory canal and middle ear. Methods and Materials: The records of 87 patients with histologically confirmed squamous cell carcinoma who were treated between 1984 and 2005 were reviewed. Fifty-three patients (61%) were treated with surgery and radiotherapy (S + RT group) and the remaining 34 patients with radiotherapy alone (RT group). Chemotherapy was administered in 34 patients (39%). Results: The 5-year actuarial overall and disease-free survival (DFS) rates for all patients were 55% and 54%, respectively. On univariate analysis, T stage (Stell's classification), treatment modality, and Karnofsky performance status had significant impact on DFS. On multivariate analysis, T stage and treatment modality were significant prognostic factors. Chemotherapy did not influence DFS. The 5-year DFS rate in T1, T2, and T3 patients was 83%, 45%, and 0 in the RT group (p < 0.0001) and 75%, 75%, and 46% in the S + RT group (p = 0.13), respectively. The 5-year DFS rate in patients with negative surgical margins, those with positive margins, and those with macroscopic residual disease was 83%, 55%, and 38%, respectively (p = 0.007). Conclusions: Radical radiotherapy is the treatment of choice for early-stage (T1) diseases, whereas surgery (negative surgical margins if possible) with radiotherapy is recommended as the standard care for advanced (T2-3) disease. Further clarification on the role of chemotherapy is necessary.

Ogawa, Kazuhiko [Department of Radiology, University of the Ryukyus, Okinawa (Japan)]. E-mail: kogawa@med.u-ryukyu.ac.jp; Nakamura, Katsumasa [Department of Clinical Radiology, Kyushu University, Fukuoka (Japan); Hatano, Kazuo [Department of Radiation Oncology, Chiba Cancer Center, Chiba (Japan); Uno, Takashi [Department of Radiation Oncology, Chiba University, Chiba (Japan); Fuwa, Nobukazu [Department of Radiation Oncology, Aichi Cancer Center, Nagoya (Japan); Itami, Jun [Department of Radiation Therapy and Oncology, International Medical Center of Japan, Tokyo (Japan); Kojya, Shizuo [Department of Otorhinolaryngology, Heart Life Hospital, Okinawa (Japan); Nakashima, Torahiko [Department of Otorhinolaryngology, Kyushu University, Fukuoka (Japan); Shinhama, Akihiko [Department of Otorhinolaryngology, University of the Ryukyus, Okinawa (Japan); Nakagawa, Takashi [Department of Otorhinolaryngology, Fukuoka University, Fukuoka (Japan); Toita, Takafumi [Department of Radiology, University of the Ryukyus, Okinawa (Japan); Sakai, Mitsuhiro [Department of Radiation Oncology, Chiba Cancer Center, Chiba (Japan); Kodaira, Takeshi [Department of Radiation Oncology, Aichi Cancer Center, Nagoya (Japan); Suzuki, Mikio [Department of Otorhinolaryngology, University of the Ryukyus, Okinawa (Japan); Ito, Hisao [Department of Radiation Oncology, Chiba University, Chiba (Japan); Murayama, Sadayuki [Department of Radiology, University of the Ryukyus, Okinawa (Japan)

2007-08-01T23:59:59.000Z

59

Supercomputing: Eye-Opening Possibilities in Imaging | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Supercomputing: Eye-Opening Possibilities in Imaging Supercomputing: Eye-Opening Possibilities in Imaging Supercomputing: Eye-Opening Possibilities in Imaging September 20, 2013 - 5:00pm Addthis This overlay of mass spectrometry images shows the spatial distribution of three different kind of lipids across a whole mouse cross-section. Lipids act as the structural components of cell membranes and are responsible for energy storage, among other things. | Photo courtesy of Wolfgang Reindl (Berkeley Lab). This overlay of mass spectrometry images shows the spatial distribution of three different kind of lipids across a whole mouse cross-section. Lipids act as the structural components of cell membranes and are responsible for energy storage, among other things. | Photo courtesy of Wolfgang Reindl (Berkeley Lab).

60

Sleepy Eye Public Utility Comm | Open Energy Information  

Open Energy Info (EERE)

Eye Public Utility Comm Eye Public Utility Comm Jump to: navigation, search Name Sleepy Eye Public Utility Comm Place Minnesota Utility Id 17320 Utility Location Yes Ownership M NERC Location MRO NERC MRO Yes ISO MISO Yes Operates Generating Plant Yes Activity Generation Yes Activity Buying Transmission Yes Activity Distribution Yes Activity Bundled Services Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Electric Heat Residential Industrial Industrial Large General Commercial Residential Residential Security Lighting- 150W Lighting Security Lighting- 175W Lighting Security Lighting- 250W Lighting

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Female Scientists, Engineers Open Students' Eyes to Career Options |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Female Scientists, Engineers Open Students' Eyes to Career Options Female Scientists, Engineers Open Students' Eyes to Career Options Female Scientists, Engineers Open Students' Eyes to Career Options June 12, 2012 - 3:43pm Addthis Students practice hooking out -- or removing -- DNA from a strawberry sample at Idaho National Laboratory. | Photo courtesy of INL. Students practice hooking out -- or removing -- DNA from a strawberry sample at Idaho National Laboratory. | Photo courtesy of INL. Kortny Rolston INL Communications & Governmental Affairs What are the key facts? 76 female students from Idaho Falls and Twin Falls attended the annual event. The event was organized by Idaho Women in Nuclear (IWIN). Portage, Inc., the American Society of Mechanical Engineers and several other groups support the event. Editor's note: This article was cross-posted from Idaho National

62

Landscaping with an Eye To Energy Efficiency | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Landscaping with an Eye To Energy Efficiency Landscaping with an Eye To Energy Efficiency Landscaping with an Eye To Energy Efficiency April 7, 2009 - 11:46am Addthis Elizabeth Spencer Communicator, National Renewable Energy Laboratory Spring is on the way, and everyone's already thinking about getting out into the warmer weather. (Unless, of course, you are as unlucky as we are up here in Colorado, and are still struggling with the occasional foot of snow...) But even if the weather isn't cooperating, you still may be interested in learning more about how you can use landscaping to make your home more energy efficient. It's one of those ideas that, while easy to overlook, makes a lot of sense: Properly planned out landscaping can help shave the peaks and valleys off of the most intense weather your home is exposed to. It can shade rooms

63

On subwavelength imaging of Maxwell's fish eye lens  

E-Print Network (OSTI)

Both explicit analysis and FEM numerical simulation are used to analyze the field distribution of a line current in the so-called Maxwell's fish eye lens, which has been claimed recently to be able to achieve perfect imaging. We show that such a Maxwell's fish eye lens cannot give perfect imaging due to the fact that high order modes of the object field can hardly reach the image point in the Maxwell's fish eye. If only zero order mode is excited, a subwavelength image can be achieved, however, its spot-size is larger than the spot size of the source field. The image resolution is determined by the field spot size of the image corresponding to the zeroth order component of the object field. Our explicit analysis consists very well with the FEM results for a modified fish eye bounded with perfectly electrical conductor (PEC). Explicit condition is given for achieving a subwavelength image. When this condition is not satisfied, a single line current source may give multiple image spots.

Sun, Fei

2010-01-01T23:59:59.000Z

64

On subwavelength imaging with Maxwell's fish eye lens  

E-Print Network (OSTI)

Both explicit analysis and FEM numerical simulation are used to analyze the field distribution of a line current in the so-called Maxwell's fish eye lens [bounded with a perfectly electrical conductor (PEC) boundary]. We show that such a 2D Maxwell's fish eye lens cannot give perfect imaging due to the fact that high order modes of the object field can hardly reach the image point in Maxwell's fish eye lens. If only zeroth order mode is excited, a subwavelength image of a sharp object may be achieved in some cases, however, its spot-size is larger than the spot size of the initial object field. The image resolution is determined by the field spot size of the image corresponding to the zeroth order component of the object field. Our explicit analysis consists very well with the FEM results for a fish eye lens. Time-domain simulation is also given to verify our conclusion. Multi-point imaging for a single object point is also demonstrated.

Sun, Fei

2010-01-01T23:59:59.000Z

65

Can Maxwell's fish eye lens really give perfect imaging?  

E-Print Network (OSTI)

Both explicit analysis and FEM numerical simulation are used to analyze the field distribution of a line current in the so-called Maxwell's fish eye lens [bounded with a perfectly electrical conductor (PEC) boundary]. We show that such a 2D Maxwell's fish eye lens cannot give perfect imaging due to the fact that high order modes of the object field can hardly reach the image point in Maxwell's fish eye lens. If only zeroth order mode is excited, a good image of a sharp object may be achieved in some cases, however, its spot-size is larger than the spot size of the initial object field. The image resolution is determined by the field spot size of the image corresponding to the zeroth order component of the object field. Our explicit analysis consists very well with the FEM results for a fish eye lens. Time-domain simulation is also given to verify our conclusion. Multi-point images for a single object point are also demonstrated.

Sun, Fei

2010-01-01T23:59:59.000Z

66

Face and Eye Detection on Hard Datasets Jon Parris1  

E-Print Network (OSTI)

Face and Eye Detection on Hard Datasets Jon Parris1 , Michael Wilber1 , Brian Heflin2 , Ham Rara3 with refinement. Similarly, [3] lever- ages parts of existing data and spends much of their discus- sion about by using the ratios de- scribed in csuPreprocessnormalize.c, part of the CSU Face Evaluation

Boult, Terrance E.

67

Face and Eye Detection on Hard Datasets , Michael Wilber  

E-Print Network (OSTI)

Face and Eye Detection on Hard Datasets Jon Parris 1 , Michael Wilber 1 , Brian Heflin 2 , Ham Rara is a dataset collected using auto mated face detection with refinement. Similarly, [3] lever ages parts the ratios de scribed in csuPreprocessnormalize. c, part of the CSU Face Evaluation and ldentification

Farag, Aly A.

68

Towards semi-automatic usability analysis through eye tracking  

Science Conference Proceedings (OSTI)

Usability is now an essential requirement for Web sites and graphical interfaces in general. Ignoring the human-computer experience in interface design may greatly limit the effectiveness of a software product, in spite of its value in terms of both ... Keywords: World Wide Web, eye tracking, interfaces, usability

Maria Grazia Albanesi; Riccardo Gatti; Marco Porta; Alice Ravarelli

2011-06-01T23:59:59.000Z

69

James M. Coughlan Smith-Kettlewell Eye Research Institute  

E-Print Network (OSTI)

of the Problem 3-D lines in Manhattan scene project to lines on uv image plane. cr ar fu rr rr = cr br fv rr rrJames M. Coughlan Smith-Kettlewell Eye Research Institute Manhattan World: Orientation and Outlier Detection by Bayesian Inference #12;Application of the statistics of edges: Manhattan World Many scenes

Coughlan, James M.

70

Seasonal and multiannual roost use by Rafinesque's Big-eared Bats in the Coastal Plain of South Carolina.  

Science Conference Proceedings (OSTI)

Little is known about factors affecting year-round use of roosts by Rafinesque's big-eared bats (Corynorhinus rafinesquii) or the long-term fidelity of this species to anthropogenic or natural roosts. The objectives of this study were to test whether seasonal use of roosts by Rafinesque's big-eared bats varied with roost type and environmental conditions within and among seasons and to document multiannual use of natural and anthropogenic structures by this species. We inspected 4 bridges, 1 building, and 59 tree roosts possessing basal cavity openings; roosts were inspected at least once per week from May through October in every year from 2005 through 2008 and once a month from November through April in every year from 2005 through 2009. We found that use of anthropogenic roosts was significantly greater than the use of tree roosts in summer but that the use of structure types did not differ in other seasons. There was significant seasonal variation in use of anthropogenic and tree roosts. Anthropogenic roost use was higher in summer than in all other seasons. There was no significant difference in tree use among spring, summer, and fall, but use in winter was significantly lower in 2 years of the study. Overall use of anthropogenic and tree roosts was positively related to minimum temperature, but the relationship between use of roosts and minimum temperature varied among seasons. Bats showed multiannual fidelity ({ge} 4 years) to all anthropogenic roosts and to some tree roosts, but fidelity of bats to anthropogenic roosts was greater and more consistent than to tree roosts. Our data indicate that Rafinesque's big-eared bats responded differently to environmental conditions among seasons; thus, a variety of structure types and characteristics are necessary for conservation of these bats. We suggest long-term protection of roost structures of all types is necessary for conservation of Rafinesque's big-eared bats in the southeast Coastal Plain.

Loeb, Susan, C.; Zarnoch, Stanley, J.

2011-12-01T23:59:59.000Z

71

Eye localization in low and standard definition content with application to face matching  

Science Conference Proceedings (OSTI)

In this paper we address the problem of eye localization for the purpose of face matching in low and standard definition image and video content. In addition to an explorative study that aimed at discovering the effect of eye localization accuracy on ... Keywords: Experimentation, Eye localization, Face detection, Face matching, Face recognition, Face registration, Local binary pattern

Bart Kroon; Sander Maas; Sabri Boughorbel; Alan Hanjalic

2009-08-01T23:59:59.000Z

72

Convergence analysis for the uncalibrated robotic handeye coordination based on the unmodeled dynamics observer  

Science Conference Proceedings (OSTI)

The uncalibrated robotic handeye coordination problem is firstly modeled by a dynamic system, where the unknown handeye relationship is regarded as the system's unmodeled dynamics. A state observer is then designed to estimate impacts of ... Keywords: State observer, Uncalibrated handeye coordination, Unmodeled dynamics, Visual servoing

Jianbo Su

2010-07-01T23:59:59.000Z

73

Forces between clustered stereocilia minimize friction in the ear on a subnanometre scale  

E-Print Network (OSTI)

The detection of sound begins when energy derived from acoustic stimuli deflects the hair bundles atop hair cells. As hair bundles move, the viscous friction between stereocilia and the surrounding liquid poses a fundamental challenge to the ear's high sensitivity and sharp frequency selectivity. Part of the solution to this problem lies in the active process that uses energy for frequency-selective sound amplification. Here we demonstrate that a complementary part involves the fluid-structure interaction between the liquid within the hair bundle and the stereocilia. Using force measurement on a dynamically scaled model, finite-element analysis, analytical estimation of hydrodynamic forces, stochastic simulation and high-resolution interferometric measurement of hair bundles, we characterize the origin and magnitude of the forces between individual stereocilia during small hair-bundle deflections. We find that the close apposition of stereocilia effectively immobilizes the liquid between them, which reduces the drag and suppresses the relative squeezing but not the sliding mode of stereociliary motion. The obliquely oriented tip links couple the mechanotransduction channels to this least dissipative coherent mode, whereas the elastic horizontal top connectors stabilize the structure, further reducing the drag. As measured from the distortion products associated with channel gating at physiological stimulation amplitudes of tens of nanometres, the balance of forces in a hair bundle permits a relative mode of motion between adjacent stereocilia that encompasses only a fraction of a nanometre. A combination of high-resolution experiments and detailed numerical modelling of fluid-structure interactions reveals the physical principles behind the basic structural features of hair bundles and shows quantitatively how these organelles are adapted to the needs of sensitive mechanotransduction.

Andrei S. Kozlov; Johannes Baumgart; Thomas Risler; Corstiaen P. C. Versteegh; A. J. Hudspeth

2012-01-03T23:59:59.000Z

74

Green's function for the wavized Maxwell fish-eye problem  

E-Print Network (OSTI)

Unique transformation properties under the hyperspherical inversion of a partial differential equation describing a stationary scalar wave in an $N$-dimensional ($N\\geqslant2$) Maxwell fish-eye medium are exploited to construct a closed form of the Green's function for that equation. For those wave numbers for which the Green's function fails to exist, the generalized Green's function is derived. Prospective physical applications are mentioned.

Szmytkowski, Rados?aw

2011-01-01T23:59:59.000Z

75

Green's function for the wavized Maxwell fish-eye problem  

E-Print Network (OSTI)

Unique transformation properties under the hyperspherical inversion of a partial differential equation describing a stationary scalar wave in an $N$-dimensional ($N\\geqslant2$) Maxwell fish-eye medium are exploited to construct a closed form of the Green's function for that equation. For those wave numbers for which the Green's function fails to exist, the generalized Green's function is derived. Prospective physical applications are mentioned.

Rados?aw Szmytkowski

2011-07-07T23:59:59.000Z

76

Comment on 'Perfect drain for the Maxwell fish eye lens'  

E-Print Network (OSTI)

The non-magnetic loss material has been proposed (2011 New J. Phys. 13 023038) to mimic a passive perfect drain in the Maxwell's fish eye lens (MFL). In this comment, we argue that this passive medium can only be treated as a perfect absorber which can totally absorb all incident radiation without scattering by it, but it cannot mimic a delta function at the image point. As a result, this passive medium cannot help to achieve a perfect focusing in MFL.

Sun, Fei

2012-01-01T23:59:59.000Z

77

High-speed camera characterization of voluntary eye blinking kinematics  

E-Print Network (OSTI)

1 High-Speed Camera Characterisation of Voluntary Eye Blinking Kinematics Kyung-Ah Kwon, Rebecca J. Shipley, Mohan Edirisinghe* Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK Daniel... , M. G. 1980 Interaction of eyelids and tears in corneal wetting and the dynamics of the normal human eyeblink. Am J Ophthalmol. 89:507-516. 4. Bologna, M., Agostino, R., Gregori, B., Belvisi, D., Ottaviani, D., Colosimo, C., Fabbrini, G...

Kwon, K-A; Shipley, RJ; Edirisinghe, M; Ezra, DG; Rose, G; Best, Serena Michelle; Cameron, Ruth Elizabeth

2013-01-01T23:59:59.000Z

78

The effects of variations in the density and composition of eye materials on ophthalmic brachytherapy dosimetry  

Science Conference Proceedings (OSTI)

In ophthalmic brachytherapy dosimetry, it is common to consider the water phantom as human eye anatomy. However, for better clinical analysis, there is a need for the dose determination in different parts of the eye. In this work, a full human eye is simulated with MCNP-4C code by considering all parts of the eye, i.e., the lens, cornea, retina, choroid, sclera, anterior chamber, optic nerve, and bulk of the eye comprising vitreous body and tumor. The average dose in different parts of this full model of the human eye is determined and the results are compared with the dose calculated in water phantom. The central axes depth dose and the dose in whole of the tumor for these 2 simulated eye models are calculated as well, and the results are compared.

Asadi, Somayeh [Department of Physics, K.N. Toosi University of Technology, Tehran (Iran, Islamic Republic of); Masoudi, Seyed Farhad, E-mail: masoudi@kntu.ac.ir [Department of Physics, K.N. Toosi University of Technology, Tehran (Iran, Islamic Republic of); Shahriari, Majid [Department of Radiation Application, Shahid Beheshti University, Tehran (Iran, Islamic Republic of)

2012-04-01T23:59:59.000Z

79

Carotenoids & Retinoids; Molecular Aspects and Health IssuesChapter 7 Macular Carotenoids in Eye Health  

Science Conference Proceedings (OSTI)

Carotenoids & Retinoids; Molecular Aspects and Health Issues Chapter 7 Macular Carotenoids in Eye Health Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf...

80

Behind Blue Eyes: A Memoir of Childhood Who Am I?: A Collection of Essays.  

E-Print Network (OSTI)

??How should one approach childhood memories for the writing of literary memoir? Behind Blue Eyes is my childhood revisited. I have fashioned my earliest memories (more)

Parry, Glyn

2006-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Results from the High Resolution Fly's Eye Experiment  

SciTech Connect

The High Resolution Fly's Eye (HiRes) Experiment operated two fluorescence detector sites in the western Utah desert between 1997 and 2006. The HiRes results on the cosmic ray spectrum are consistent with the GZK Suppression predicted at 10{sup 19.8} eV and observe an ankle structure at 10{sup 18.5} eV. These spectral features are consistent with a proton-dominated composition for cosmic rays at the highest energies. The HiRes composition studies of both the mean and the variance of the shower maximum depth (X{sub max}) also give results that are completely consistent with a predominately protonic composition, and inconsistent with heavy nuclei such as iron. We also report on the result of anisotropy studies.

Jui, C. C. H. [Department of Physics, University of Utah, 115 S. 1400 E. Rm. 201 Salt Lake City, Utah, 84112-0830 (United States)

2011-09-22T23:59:59.000Z

82

An Eye on Energy Performance - Provider, March 2011  

NLE Websites -- All DOE Office Websites (Extended Search)

54 Provider * March 2011 54 Provider * March 2011 Management Proper installation of new equipment and diagnostic testing of existing systems can achieve surprising levels of energy efficiency, even in older buildings. C l a r k r e e d An Eye On Energy Performance I magine two buildings: one is brand new with all the latest energy-efficient windows, lighting, and insulation. The second building plods along using older technologies installed 20 years ago. Which one is more energy efficient? Surprisingly, older buildings can often win the race of delivering better energy perfor- mance than new ones. As impossible as it sounds, this happens time and again among buildings of every size. The Environmental Protection Agency's ENERGY STAR rating system, which was recently expanded to

83

Perfect drain for the Maxwell Fish Eye lens  

E-Print Network (OSTI)

Perfect imaging for electromagnetic waves using the Maxwell Fish Eye (MFE) requires a new concept: the perfect drain. From the mathematical point of view, a perfect point drain is just like an ideal point source, except that it drains power from the electromagnetic field instead of generating it. We show here that the perfect drain for the MFE can be seen as a dissipative region the diameter of which tends to zero. The complex permittivity $\\varepsilon$ of this region cannot take arbitrary values, however, since it depends on the size of the drain as well as on the frequency. This interpretation of the perfect drain connects well with central concepts of electromagnetic theory. This opens up both the modeling in computer simulations and the experimental verification of the perfect drain.

Gonzalez, Juan C; Minano, Juan C

2010-01-01T23:59:59.000Z

84

Using hidden Markov model to uncover processing states from eye movements in information search tasks  

Science Conference Proceedings (OSTI)

We study how processing states alternate during information search tasks. Inference is carried out with a discriminative hidden Markov model (dHMM) learned from eye movement data, measured in an experiment consisting of three task types: (i) simple word ... Keywords: Computational models, Decision process, Eye movements, Hidden Markov model, Information search, Reading, Scanning

Jaana Simola; Jarkko SalojRvi; Ilpo Kojo

2008-10-01T23:59:59.000Z

85

Determining surface orientation from fixated eye position and angular visual extent  

E-Print Network (OSTI)

Determining surface orientation from fixated eye position and angular visual extent Nicola J computer vision algorithms can be used to determine surface orientation information, most re­ quire of sur­ face orientation. A sensitivity analysis based on accuracy of eye po­ sition control parameters

Sheridan, Jennifer

86

ViewPointer: lightweight calibration-free eye tracking for ubiquitous handsfree deixis  

Science Conference Proceedings (OSTI)

We introduce ViewPointer, a wearable eye contact sensor that detects deixis towards ubiquitous computers embedded in real world objects. ViewPointer consists of a small wearable camera no more obtrusive than a common Bluetooth headset. ViewPointer allows ... Keywords: attentive user interface, eye tracking

John D. Smith; Roel Vertegaal; Changuk Sohn

2005-10-01T23:59:59.000Z

87

Wildlife Diseases  

E-Print Network (OSTI)

Some wildlife diseases can be transmitted to humans. This leaflet explains the causes and symptoms of rabies, giardiasis, bubonic plague, Rocky Mountain spotted fever, Lyme disease, tularemia, leptospirosis and histoplasmosis.

Texas Wildlife Services

2007-03-13T23:59:59.000Z

88

Building high availability with SteelEye LifeKeeper for SAP NetWeaver on SUSE Linux enterprise server  

E-Print Network (OSTI)

Building high availability with SteelEye LifeKeeper for SAP NetWeaver on SUSE Linux enterprise server

2008-01-01T23:59:59.000Z

89

FDA Approves First Bionic Eye for the Blind | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FDA Approves First Bionic Eye for the Blind FDA Approves First Bionic Eye for the Blind FDA Approves First Bionic Eye for the Blind February 14, 2013 - 1:06pm Addthis NEWS MEDIA CONTACT (202) 586-4940 WASHINGTON- The U.S. Department of Energy announced today that its support for a decade of revolutionary research has contributed to the creation of the first ever retinal prosthesis - or bionic eye - to be approved in the United States by the U.S. Food and Drug Administration for blind individuals with end-stage retinitis pigmentosa. "The development of the artificial retina is just one more example of the unique value of our National Laboratories and research universities," said Energy Secretary Steven Chu. "While no one can predict a breakthrough before it happens, the investments we're making in research

90

Reply to comment on Perfect drain for the Maxwell fish eye lens  

E-Print Network (OSTI)

We reply to the comments on our paper Perfect Drain for the Maxwell fish eye lens (NJP 13 (2011) 023038) made by Fei Sun. We believe that Sun comments have several mistakes in theoretical concepts and simulation results.

Gonzalez, Juan C; Minnano, Juan C; Grabovickic, Dejan

2013-01-01T23:59:59.000Z

91

Eye movement guidance in familiar visual scenes : a role for scene specific location priors in search  

E-Print Network (OSTI)

Ecologically relevant search typically requires making rapid and strategic eye movements in complex, cluttered environments. Attention allocation is known to be influenced by low level image features, visual scene context, ...

Hidalgo-Sotelo, Barbara

2010-01-01T23:59:59.000Z

92

Achieving eye contact in a one-to-many 3D video teleconferencing system  

Science Conference Proceedings (OSTI)

We present a set of algorithms and an associated display system capable of producing correctly rendered eye contact between a three-dimensionally transmitted remote participant and a group of observers in a 3D teleconferencing system. The participant's ...

Andrew Jones; Magnus Lang; Graham Fyffe; Xueming Yu; Jay Busch; Ian McDowall; Mark Bolas; Paul Debevec

2009-07-01T23:59:59.000Z

93

Stability, unfolding, and aggregation of the gamma D and gamma S human eye lens crystallins  

E-Print Network (OSTI)

The transparency of the human eye lens depends on the properties of the a- crystallin and py-crystallin families of proteins, which accumulate to very high concentrations in mature lens fiber cells. The 0- and y-crystallins ...

Mills-Henry, Ishara Amenti Rakem

2007-01-01T23:59:59.000Z

94

Invisible Colors of Light Colors are the way human eyes (and the brain)  

E-Print Network (OSTI)

of the visible/ infrared spectrum is shown below. Note that the scale is logarithmic; each equally-spaced, a roaring fire, a radiator or a warm sidewalk is infrared radiation. Although our eyes cannot see it

95

Research Paper Dielectric properties of cowpea weevil, black-eyed peas and  

E-Print Network (OSTI)

depth. Dielectric properties of black-eyed pea and mung bean flours at four moisture content levels.12.010 #12;phosphine (Benhalima, Chaudhry, Mills, & Price, 2004) may make these fumigants costly

Tang, Juming

96

Context Effects in Coercion: Evidence from Eye-Movements  

E-Print Network (OSTI)

Four eye-movement monitoring studies examined the processing of expressions argued to require enriched semantic composition (Pustejovsky, 1995). Previous research found that noun phrases denoting entities (e.g., the book) were difficult to process following verbs that require event complements (e.g., begin). Expressions like began the book may be difficult to process because they require complex operations to construct an event sense (e.g., began writing the book), they engender competition between alternative interpretations (cf. began reading the book), or they require a costly retrieval operation to recover a suitable activity (e.g., reading). Introducing the activity before a target expression did not eliminate the processing cost (Experiments 1 and 2), but introducing the entire event sense did (Experiments 3 and 4). These findings are incompatible with ambiguity- or retrieval-based accounts and suggest that interpretation is costly when composition requires construction of a sense not lexically stored or available in the immediate discourse. 3 A suitable interpretation for an expression, a phrase or clause, can sometimes be derived by simply combining key semantic properties of the individual words according to their syntactic position in the sentence (e.g., Jackendoff, 1997, 2002). In such circumstances, semantic properties retrieved from lexical representations and grammatical constraints associated with syntactic representations will uniquely determine the interpretation of the expression. Accordingly, the compositional mechanism---the critical interface between lexical and syntactic processing on one hand and discourse and text comprehension on the other---might be thought of as rather minimal, consisting merely of rules or principles for recursively combining...

Matthew J. Traxler; Matthew J. Traxler; Brian McElree; Rihana S. Williams; Martin J. Pickering

2002-01-01T23:59:59.000Z

97

Neurological Disease  

NLE Websites -- All DOE Office Websites (Extended Search)

Iron and neurodegenerative disease Iron and neurodegenerative disease A novel technique to study intracerebral iron oxide particles associated with Alzheimer's, Huntington's, and Parkinson's diseases has been developed. Researchers crafted a system of mirrors and lenses to tap one of the high-brightness x-ray sources at the Advanced Photon Source for the purpose of analyzing brain tissue. Mark Davidson (left in the photo), University of Florida, and Joanna Collingwood, Keele University in the United Kingdom (UK, who is supported by a UK Alzheimer's Society Research Fellowship and Dunhill Medical Trust), align a sample of Alzheimer's brain tissue at the microfocus facility, MR-CAT, beamline 10-ID. According to Davidson: "Unusual iron mineral nanoscale deposits have been associated with many neurodegenerative diseases, such as Alzheimer's,

98

Parkinson's Disease  

NLE Websites -- All DOE Office Websites (Extended Search)

Parkinson's Disease Parkinson's Disease Name: saabsaab Status: N/A Age: N/A Location: N/A Country: N/A Date: Around 1993 Question: I am interested in collecting information on Parkinson's Disease. Can you help me? Replies: Some possible sources include a neuroscience reference, a neurology text, a neurologist, neuroanatomy references. Basically Parkinson's disease is a movement disorder. It gets more and more difficult to move. One of the primary brain lesions associated with this disease is a shrinkage of an area in the brain stem called the substantia nigra. This is thought to be associated with the neurotransmitter dopamine and there seems to decreased production of the dopamine in this area. Some medications do seem to help including a dopamine replacement medicine called Sinemet. There are some new medicines coming out that may also help. Another exciting area is trying to get new dopamine cells to grow in the substantia nigra area, one way is to insert a needle into the area and inject immature nerve cells into the area and hope they will grow up to be mature dopamine producers, so far it is still considered somewhat experimental. The disease is thought to be caused by progressive cell loss. Some cases have been caused by people who synthesized drugs to abuse and they made a mistake and a bunch of young people took the drug and ended up with the disease. The silver lining of this is that this drug also will do the same thing in rats, so now there is an animal model for Parkinson's.

99

Can Maxwell's Fish Eye Lens Really Give Perfect Imaging? Part II. The case with drains  

E-Print Network (OSTI)

We use both FEM (finite element method) and FDTD (finite difference time domain method) to simulate the field distribution in Maxwell's fish eye lens with one or more passive drains around the image point. We use the same Maxwell's fish eye lens structure as the one used in recent microwave experiment [arXiv:1007.2530]: Maxwell's fish eye lens bounded by PEC (perfect electric conductor) is inserted between two parallel PEC plates (as a waveguide structure). Our simulation results indicate that if one uses an active coaxial cable as the object and set an array of passive drains around the image region, what one obtains is not an image of the object but only multiple spots resembling the array of passive drains. The resolution of Maxwell's fish eye is finite even with such passive drains at the image locations. We also found that the subwavelength spot around the passive drain is due to the local field enhancement of the metal tip of the drain rather than the fish eye medium or the ability of the drain in extra...

Sun, Fei; He, Sailing

2010-01-01T23:59:59.000Z

100

All Eyes on Eastport: Tidal Energy Project Brings Change, Opportunity to  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

All Eyes on Eastport: Tidal Energy Project Brings Change, All Eyes on Eastport: Tidal Energy Project Brings Change, Opportunity to Local Community All Eyes on Eastport: Tidal Energy Project Brings Change, Opportunity to Local Community July 24, 2012 - 2:40pm Addthis Captain Gerald "Gerry" Morrison, Vice President of Perry Marine & Consctruction. | Photo Courtesy of Ocean Renewable Power Company. Captain Gerald "Gerry" Morrison, Vice President of Perry Marine & Consctruction. | Photo Courtesy of Ocean Renewable Power Company. Erin R. Pierce Erin R. Pierce Digital Communications Specialist, Office of Public Affairs Today in Eastport, Maine, people are gathering to celebrate a project that will harness the power of the massive tides of Cobscook Bay to generate clean electricity. At a public dedication event this afternoon, Portland-based Ocean Renewable

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Development and Usability Evaluation of an E-learning Application Using Eye-tracking  

E-Print Network (OSTI)

The primary goal of this research is to use eye-tracking in the development and usability evaluation of an e-learning tool called "Problem Solving Environment for Continuous Process Design" (PSE). The PSE is meant to aid engineering students in learning the design processes of automated manufacturing systems. PSE is a user-interactive Flash application which gives the user an opportunity to virtually design an automated industrial process by manipulating the parameters associated with it. PSE is evaluated using eye-tracking experiments in which users' eye movements are tracked using camera and sensors to determine users' gaze direction and fixations. The data collected from the experiment is used to determine if use of visual cues improved the usability of the PSE. Results show that use of visual cues for gaze direction improved the usability of the PSE application, based on faster task completion times and improved navigability.

Deotale, Punit Ashok

2011-05-01T23:59:59.000Z

102

Tracking Santa With Our Eyes in the Sky | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Tracking Santa With Our Eyes in the Sky Tracking Santa With Our Eyes in the Sky Tracking Santa With Our Eyes in the Sky December 24, 2013 - 10:00am Addthis The Energy Department's Los Alamos National Lab is tracking Santa Claus as he circles the globe the night before Christmas. The Energy Department's Los Alamos National Lab is tracking Santa Claus as he circles the globe the night before Christmas. Michael Hess Michael Hess Former Digital Communications Specialist, Office of Public Affairs Every year since 1998, the Energy Department's Los Alamos National Lab has been using state-of-the-art technology to track Santa Claus as he circles the globe the night before Christmas. You'll be able to monitor St. Nick's journey here starting at 6 a.m. ET on Christmas Eve. Since Santa doesn't file his flight path with the Federal Aviation

103

Apartment Hunting with an Eye to Energy Savings: Part I | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

with an Eye to Energy Savings: Part I with an Eye to Energy Savings: Part I Apartment Hunting with an Eye to Energy Savings: Part I August 10, 2010 - 5:30pm Addthis Kyle Rudzinski Special Assistant to the Director of Technology Advancement and Outreach, EERE Apartment hunting can be a long and stressful process. Finding that right place is difficult, let alone finding the right place with the right price. What's rent? What's the neighborhood like? How big is the closet? How long will my commute take? Was the kitchen recently re-finished? Are there hardwood floors? We think about so many things in hopes of finding the right fit. I recently went apartment hunting. After a few days and 15 apartment complexes, I finally found the right fit at the right price. Despite what my brothers say, I don't think I'm cheap. I'm frugal. Or

104

Demand Response: Lessons Learned with an Eye to the Future | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Demand Response: Lessons Learned with an Eye to the Future Demand Response: Lessons Learned with an Eye to the Future Demand Response: Lessons Learned with an Eye to the Future July 11, 2013 - 11:56am Addthis Patricia A. Hoffman Patricia A. Hoffman Assistant Secretary, Office of Electricity Delivery & Energy Reliability In today's world of limited resources and rising costs, everyone is looking for ways to use what they have more effectively while, at the same time, controlling - and ideally - reducing expenses. The electricity industry is no exception. Through demand response programs such as time-based rates in which customers are offered financial incentives to reduce or shift their consumption during peak periods, utilities are reducing demand and better managing their assets while also giving consumers more options and lowering the cost of electricity. For example,

105

Apartment Hunting with an Eye to Energy Savings: Part I | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Apartment Hunting with an Eye to Energy Savings: Part I Apartment Hunting with an Eye to Energy Savings: Part I Apartment Hunting with an Eye to Energy Savings: Part I August 10, 2010 - 5:30pm Addthis Kyle Rudzinski Special Assistant to the Director of Technology Advancement and Outreach, EERE Apartment hunting can be a long and stressful process. Finding that right place is difficult, let alone finding the right place with the right price. What's rent? What's the neighborhood like? How big is the closet? How long will my commute take? Was the kitchen recently re-finished? Are there hardwood floors? We think about so many things in hopes of finding the right fit. I recently went apartment hunting. After a few days and 15 apartment complexes, I finally found the right fit at the right price. Despite what my brothers say, I don't think I'm cheap. I'm frugal. Or

106

Brainwaves as a Biometric Parameter for Unique Identification and Authentication  

A number of biometric parameters exist for positive identification of individuals including, fingerprints, facial recognition, ear pattern, eye iris ...

107

Fuzzy multi-criteria decision making in stereovision matching for fish-eye lenses in forest analysis  

Science Conference Proceedings (OSTI)

This paper describes a novel stereovision matching approach based on omni-directional images obtained with fish-eye lenses in forest environments. The goal is to obtain a disparity map as a previous step for determining the volume of wood in the imaged ... Keywords: fish-eye stereo vision, fuzzy multi-criteria decision making, omni-directional forest images, stereovision matching

P. J. Herrera; G. Pajares; M. Guijarro; J. J. Ruz; J. M. De La Cruz

2009-09-01T23:59:59.000Z

108

Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa  

NLE Websites -- All DOE Office Websites (Extended Search)

Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa Age-related macular degeneration (AMD) is an eye disease primarily affecting the central vision regions in people age 60 and older. According to the Macular Degeneration Research Fund, a case of AMD is diagnosed in the United States every 3 minutes. Each year, 1.2 million of the estimated 12 million people with AMD will suffer severe vision loss. Patients with AMD have dark areas in their vision caused by fluid leakage or bleeding in the macula, the center of the retina that produces the sharpest vision. The brain initially compensates for these dark patches. Early cellular dysfunction or spotting in the macula may go undetected until the disease is in advanced stages.

109

How learners use awareness cues about their peer's knowledge?: insights from synchronized eye-tracking data  

Science Conference Proceedings (OSTI)

In an empirical study, eye-gaze patterns of pairs of students were recorded and analyzed in a remote situation where they had to build a concept map collaboratively. They were provided (or not), with a knowledge awareness tool that provided learner A ...

Mirweis Sangin; Galle Molinari; Marc-Antoine Nssli; Pierre Dillenbourg

2008-06-01T23:59:59.000Z

110

Sky View Factors from High-Resolution Scanned Fish-eye Lens Photographic Negatives  

Science Conference Proceedings (OSTI)

A computerized method for calculating the sky view factor from fish-eye lens photographic negatives is presented. The images are scanned and stored on CD ROM, each CD holding 100 images. The images can be retrieved at very high resolutions of up ...

Kristina Blennow

1995-12-01T23:59:59.000Z

111

Document classification on relevance: a study on eye gaze patterns for reading  

Science Conference Proceedings (OSTI)

This paper presents a study that investigates the connection between the way that people read and the way that they understand content. The experiment consisted of having participants read some information on selected documents while an eye-tracking ... Keywords: artificial neural networks, document classification, gaze pattern, reading behavior, relevance, statistical analysis

Daniel Fahey; Tom Gedeon; Dingyun Zhu

2011-11-01T23:59:59.000Z

112

Investigating the Association of Eye Gaze Pattern and Diagnostic Error in Mammography  

SciTech Connect

The objective of this study was to investigate the association between eye-gaze patterns and the diagnostic accuracy of radiologists for the task of assessing the likelihood of malignancy of mammographic masses. Six radiologists (2 expert breast imagers and 4 Radiology residents of variable training) assessed the likelihood of malignancy of 40 biopsy-proven mammographic masses (20 malignant and 20 benign) on a computer monitor. Eye-gaze data were collected using a commercial remote eye-tracker. Upon reviewing each mass, the radiologists were also asked to provide their assessment regarding the probability of malignancy of the depicted mass as well as a rating regarding the perceived difficulty of the diagnostic task. The collected data were analyzed using established algorithms and various quantitative metrics were extracted to characterize the recorded gaze patterns. The extracted metrics were correlated with the radiologists diagnostic decisions and perceived complexity scores. Results showed that the visual gaze pattern of radiologists varies substantially, not only depending on their experience level but also among individuals. However, some eye gaze metrics appear to correlate with diagnostic error and perceived complexity more consistently. These results suggest that although gaze patterns are generally associated with diagnostic error and the human perceived difficulty of the diagnostic task, there are substantially individual differences that are not explained simply by the experience level of the individual performing the diagnostic task.

Voisin, Sophie [ORNL; Pinto, Frank M [ORNL; Xu, Songhua [ORNL; Morin-Ducote, Garnetta [University of Tennessee, Knoxville (UTK); Hudson, Kathy [University of Tennessee, Knoxville (UTK); Tourassi, Georgia [ORNL

2013-01-01T23:59:59.000Z

113

Gaze Estimation for Off-Angle Iris Recognition Based on the Biometric Eye Model  

SciTech Connect

Iris recognition is among the highest accuracy biometrics. However, its accuracy relies on controlled high quality capture data and is negatively affected by several factors such as angle, occlusion, and dilation. Non-ideal iris recognition is a new research focus in biometrics. In this paper, we present a gaze estimation method designed for use in an off-angle iris recognition framework based on the ANONYMIZED biometric eye model. Gaze estimation is an important prerequisite step to correct an off-angle iris images. To achieve the accurate frontal reconstruction of an off-angle iris image, we first need to estimate the eye gaze direction from elliptical features of an iris image. Typically additional information such as well-controlled light sources, head mounted equipment, and multiple cameras are not available. Our approach utilizes only the iris and pupil boundary segmentation allowing it to be applicable to all iris capture hardware. We compare the boundaries with a look-up-table generated by using our biologically inspired biometric eye model and find the closest feature point in the look-up-table to estimate the gaze. Based on the results from real images, the proposed method shows effectiveness in gaze estimation accuracy for our biometric eye model with an average error of approximately 3.5 degrees over a 50 degree range.

Karakaya, Mahmut [ORNL; Barstow, Del R [ORNL; Santos-Villalobos, Hector J [ORNL; Thompson, Joseph W [ORNL; Bolme, David S [ORNL; Boehnen, Chris Bensing [ORNL

2013-01-01T23:59:59.000Z

114

Performance analysis of an integrated eye gaze tracking / electromyogram cursor control system  

Science Conference Proceedings (OSTI)

Eye Gaze Tracking (EGT) systems allow individuals with motor disabilities to quickly move a screen cursor on a PC. However, there are limitations in the steadiness and the accuracy of cursor control and clicking capabilities they provide. On the other ... Keywords: EGT, EMG, cursor control, motor disabilities

Craig A. Chin; Armando Barreto; Gualberto Cremades; Malek Adjouadi

2007-10-01T23:59:59.000Z

115

No-look notes: accessible eyes-free multi-touch text entry  

Science Conference Proceedings (OSTI)

Mobile devices with multi-touch capabilities are becoming increasingly common, largely due to the success of the Apple iPhone and iPod Touch. While there have been some advances in touchscreen accessibility for blind people, touchscreens remain inaccessible ... Keywords: accessibility, eyes-free, mobile device, multi-touch, text entry, touchscreen

Matthew N. Bonner; Jeremy T. Brudvik; Gregory D. Abowd; W. Keith Edwards

2010-05-01T23:59:59.000Z

116

Observed Tropical Cyclone Eye Thermal Anomaly Profiles Extending Above 300 hPa  

Science Conference Proceedings (OSTI)

As recently pointed out by Stern and Nolan (2012), much of our knowledge of the warm core structure of the tropical cyclone eye has come from composites of in situ data taken from multiple aircraft studies of three storms in the late 1950s and ...

Stephen L. Durden

117

Eye Excess Energy and the Rapid Intensification of Hurricane Lili (2002)  

Science Conference Proceedings (OSTI)

Over 4.5 days, NOAA and U.S. Air Force personnel in reconnaissance aircraft deployed 44 global positioning system dropwindsondes (GPS sondes) in the eye of Hurricane Lili (2002). The vertical profiles derived from these GPS sondes were used to ...

Gary M. Barnes; Paul Fuentes

2010-04-01T23:59:59.000Z

118

Eye-Shield: protecting bystanders from being blinded by mobile projectors  

Science Conference Proceedings (OSTI)

This paper introduces Eye-Shield, a mobile projector-camera prototype designed for the purpose of protecting people from being accidently blinded with a handheld projector. Since they might be used regularly in public space, mobile projectors can be ... Keywords: blinding light suppression, camera, face detection, mobile projector, social aspects

Bonifaz Kaufmann; Martin Hitz

2011-11-01T23:59:59.000Z

119

Scanning Eye-Safe Elastic Backscatter Lidar at 1.54 ?m  

Science Conference Proceedings (OSTI)

A field-deployable scanning direct-detection elastic backscatter lidar system that is eye safe at all ranges is presented. The first two-dimensional spatial images created by scanning this new 1.54-?m wavelength system, and time-lapse animations (...

Scott M. Spuler; Shane D. Mayor

2005-06-01T23:59:59.000Z

120

Watchit: simple gestures and eyes-free interaction for wristwatches and bracelets  

Science Conference Proceedings (OSTI)

We present WatchIt, a prototype device that extends interaction beyond the watch surface to the wristband, and two interaction techniques for command selection and execution. Because the small screen of wristwatch computers suffers from visual occlusion ... Keywords: continuous input, digital jewelry, eyes-free interaction, input, scrolling, watch, watch bracelet, watchband, watchstrap, wearable computing

Simon T. Perrault; Eric Lecolinet; James Eagan; Yves Guiard

2013-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Radiobiology for eye plaque brachytherapy and evaluation of implant duration and radionuclide choice using an objective function  

Science Conference Proceedings (OSTI)

Purpose: Clinical optimization of Collaborative Ocular Melanoma Study (COMS) eye plaque brachytherapy is currently limited to tumor coverage, consensus prescription dosage, and dose calculations to ocular structures. The biologically effective dose (BED) of temporary brachytherapy treatments is a function of both chosen radionuclide R and implant duration T. This study endeavored to evaluate BED delivered to the tumor volume and surrounding ocular structures as a function of plaque position P, prescription dose, R, and T. Methods: Plaque-heterogeneity-corrected dose distributions were generated with MCNP5 for the range of currently available COMS plaques loaded with sources using three available low-energy radionuclides. These physical dose distributions were imported into the PINNACLE{sup 3} treatment planning system using the TG-43 hybrid technique and used to generate dose volume histograms for a T = 7 day implant within a reference eye geometry including the ciliary body, cornea, eyelid, foveola, lacrimal gland, lens, optic disc, optic nerve, retina, and tumor at eight standard treatment positions. The equation of Dale and Jones was employed to create biologically effective dose volume histograms (BEDVHs), allowing for BED volumetric analysis of all ROIs. Isobiologically effective prescription doses were calculated for T = 5 days down to 0.01 days, with BEDVHs subsequently generated for all ROIs using correspondingly reduced prescription doses. Objective functions were created to evaluate the BEDVHs as a function of R and T. These objective functions are mathematically accessible and sufficiently general to be applied to temporary or permanent brachytherapy implants for a variety of disease sites. Results: Reducing T from 7 to 0.01 days for a 10 mm plaque produced an average BED benefit of 26%, 20%, and 17% for {sup 103}Pd, {sup 125}I, and {sup 131}Cs, respectively, for all P; 16 and 22 mm plaque results were more position-dependent. {sup 103}Pd produced a 16%-35% BED benefit over {sup 125}I, whereas {sup 131}Cs produced a 3%-7% BED detriment, independent of P, T, and plaque size. Additionally, corresponding organ at risk physical doses were lowest using {sup 103}Pd in all circumstances. Conclusions: The results suggest that shorter implant durations may correlate with more favorable outcomes compared to 7 day implants when treating small or medium intraocular lesions. The data also indicate that implant duration may be safely reduced if the prescription physical dose is likewise diminished and that {sup 103}Pd offers a substantial radiobiological benefit over {sup 125}I and {sup 131}Cs irrespective of plaque position, implant duration, and tumor size.

Gagne, Nolan L.; Leonard, Kara L.; Rivard, Mark J. [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States)

2012-06-15T23:59:59.000Z

122

Longitudinal Studies utilizing Local Neural Retinal Function, measured by Multifocal Electroretinograms, for the Prediction of Diabetic Eye Disease  

E-Print Network (OSTI)

SE, Cruickshanks KJ. The Wisconsin Epidemiologic Study oftype 2 diabetes: XXI: the Wisconsin Epidemiologic Study ofJAMA University of Wisconsin Department of Ocular

Harrison, Wendy Watkins

2011-01-01T23:59:59.000Z

123

Fusion through the eyes of a veteran science journalist | Princeton Plasma  

NLE Websites -- All DOE Office Websites (Extended Search)

Fusion through the eyes of a veteran science journalist Fusion through the eyes of a veteran science journalist July 15, 2013 Tweet Widget Facebook Like Google Plus One Daniel Clery (Photo by Sadie Windscheffel-Clarke) Daniel Clery Gallery: Author Daniel Clery recently published "A Piece of the Sun," a 320-page narrative of the history of fusion research and the personalities who have devoted their careers to it. Clery is a United Kingdom-based reporter for Science magazine who holds a bachelor's degree in theoretical physics from York University and has covered fusion for more than a decade. While hardly an uncritical flag-waver for fusion, he recognizes its vast potential. He discussed his new book and the future of fusion with PPPL Science Writer John Greenwald. How did you gather your detailed information from labs like PPPL?

124

New Eyes on the Expanding Universe: The SuperNova/Acceleration Probe (SNAP)  

NLE Websites -- All DOE Office Websites (Extended Search)

New Eyes on the Expanding Universe: The SuperNova/Acceleration Probe (SNAP) New Eyes on the Expanding Universe: The SuperNova/Acceleration Probe (SNAP) The Equation of the Universe PowerPoint Presentation The Cosmological Constant Slide 5 Hubble's Great Discovery - and Einstein's "biggest blunder" Slide 7 Slide 8 Slide 9 Slide 10 Slide 11 Slide 12 Slide 13 Slide 14 A Revolution in Cosmology Slide 16 Who Ordered That?! What we don't know Slide 19 Slide 20 Slide 21 Dark Energy Task Force Slide 23 Slide 24 Slide 25 Slide 26 Slide 27 "Standard-izable" Candles Slide 29 Slide 30 Slide 31 Slide 32 Slide 33 Slide 34 Slide 35 Slide 36 Slide 37 Slide 38 Slide 39 What is the Physical Mechanism for Type Ia SNe? Discovering Supernovae Slide 42 The Expansion History of the Universe Discovering Supernovae from Space Gravitational Weak Lensing Slide 46 Slide 47

125

Using Bulls-Eye Commissioning to Save Energy in Commercial Buildings  

E-Print Network (OSTI)

Building system commissioning comes highly recommended by energy efficiency experts; however, it is rarely undertaken due to the cost and care needed to do a comprehensive job. Many existing utility meters provide whole-building 15-minute interval data that can be used to pinpoint fan control and HVAC schedule problems. Bulls-eye commissioning uses interval metering to focus detailed commissioning efforts. This paper concentrates on a single customer and how bulls-eye commissioning can be applied to focus the commissioning process. Significant energy savings were found by using interval data in conjunction with outside air temperature to isolate problems with schedules and in the economizer controls. Evaluation of main meter profiles allows detailed commissioning work to be better focused and more effective without the wait and expense of full commissioning services. Bulls-eye commissioning can be applied on its own or can be coordinated with traditional commissioning. In either case, the main meter profile shows what will directly impact total energy use and the customer's bill.

Price, W.; Hart, R.

2002-01-01T23:59:59.000Z

126

Eye tracking and gating system for proton therapy of orbital tumors  

Science Conference Proceedings (OSTI)

Purpose: A new motion-based gated proton therapy for the treatment of orbital tumors using real-time eye-tracking system was designed and evaluated. Methods: We developed our system by image-pattern matching, using a normalized cross-correlation technique with LabVIEW 8.6 and Vision Assistant 8.6 (National Instruments, Austin, TX). To measure the pixel spacing of an image consistently, four different calibration modes such as the point-detection, the edge-detection, the line-measurement, and the manual measurement mode were suggested and used. After these methods were applied to proton therapy, gating was performed, and radiation dose distributions were evaluated. Results: Moving phantom verification measurements resulted in errors of less than 0.1 mm for given ranges of translation. Dosimetric evaluation of the beam-gating system versus nongated treatment delivery with a moving phantom shows that while there was only 0.83 mm growth in lateral penumbra for gated radiotherapy, there was 4.95 mm growth in lateral penumbra in case of nongated exposure. The analysis from clinical results suggests that the average of eye movements depends distinctively on each patient by showing 0.44 mm, 0.45 mm, and 0.86 mm for three patients, respectively. Conclusions: The developed automatic eye-tracking based beam-gating system enabled us to perform high-precision proton radiotherapy of orbital tumors.

Shin, Dongho; Yoo, Seung Hoon; Moon, Sung Ho; Yoon, Myonggeun; Lee, Se Byeong; Park, Sung Yong [Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi 410-769 (Korea, Republic of); Department of Radiation Oncology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi 463-712 (Korea, Republic of); Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi 410-769 (Korea, Republic of); Department of Radiological Science, Korea University, Seoul 136-703 (Korea, Republic of); Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi 410-769 (Korea, Republic of); Proton Therapy Center, McLaren Cancer Institute, Flint, Michigan 48532 (United States)

2012-07-15T23:59:59.000Z

127

Alternative construction of the closed form of the Green's function for the wavized Maxwell fish-eye problem  

E-Print Network (OSTI)

In the recent paper [J.\\ Phys.\\ A 44 (2011) 065203], we have arrived at the closed-form expression for the Green's function for the partial differential operator describing propagation of a scalar wave in an $N$-dimensional ($N\\geqslant2$) Maxwell fish-eye medium. The derivation has been based on unique transformation properties of the fish-eye wave equation under the hyperspherical inversion. In this communication, we arrive at the same expression for the fish-eye Green's function following a different route. The alternative derivation we present here exploits the fact that there is a close mathematical relationship, through the stereographic projection, between the wavized fish-eye problem in $\\mathbb{R}^{N}$ and the problem of propagation of scalar waves over the surface of the $N$-dimensional hypersphere.

Rados?aw Szmytkowski

2011-07-09T23:59:59.000Z

128

Alternative construction of the closed form of the Green's function for the wavized Maxwell fish-eye problem  

E-Print Network (OSTI)

In the recent paper [J.\\ Phys.\\ A 44 (2011) 065203], we have arrived at the closed-form expression for the Green's function for the partial differential operator describing propagation of a scalar wave in an $N$-dimensional ($N\\geqslant2$) Maxwell fish-eye medium. The derivation has been based on unique transformation properties of the fish-eye wave equation under the hyperspherical inversion. In this communication, we arrive at the same expression for the fish-eye Green's function following a different route. The alternative derivation we present here exploits the fact that there is a close mathematical relationship, through the stereographic projection, between the wavized fish-eye problem in $\\mathbb{R}^{N}$ and the problem of propagation of scalar waves over the surface of the $N$-dimensional hypersphere.

Szmytkowski, Rados?aw

2011-01-01T23:59:59.000Z

129

How Does the Eye Warm? Part I: A Potential Temperature Budget Analysis of an Idealized Tropical Cyclone  

Science Conference Proceedings (OSTI)

In this first part of a two-part study, the mechanisms that accomplish the warming in the eye of tropical cyclones are investigated through a potential temperature budget analysis of an idealized simulation. The spatial structure of warming varies ...

Daniel P. Stern; Fuqing Zhang

2013-01-01T23:59:59.000Z

130

Techniques for measuring atmospheric aerosols at the High Resolution Fly's Eye experiment  

E-Print Network (OSTI)

We describe several techniques developed by the High Resolution Fly's Eye experiment for measuring aerosol vertical optical depth, aerosol horizontal attenuation length, and aerosol phase function. The techniques are based on measurements of side-scattered light generated by a steerable ultraviolet laser and collected by an optical detector designed to measure fluorescence light from cosmic-ray air showers. We also present a technique to cross-check the aerosol optical depth measurement using air showers observed in stereo. These methods can be used by future air fluorescence experiments.

The HiRes Collaboration

2005-12-15T23:59:59.000Z

131

Treatment of bovine cancer-eye (and other animal tumors) with heat  

SciTech Connect

Hyperthermia appears to be an excellent technique for the treatment of a variety of animal tumors. While this report has emphasized the application of hyperthermia to bovine cancer-eye, there cannot be serious doubt about the potential for wider applications of the technique. We have collaborated with the Animal Resource Facility at the University of New Mexico in the successful treatment of a variety of tumors in small animals which would not be a particular interest to stockmen, but the program included the successful treatment of a number of sarcoids in horses. This investigation involving heat effects on sarcoids will continue, but early results appear to be promising. Other veterinarians are using the commercial hyperthermia instruments to treat a variety of small-animal tumors; these practitioners are enthusiastic about the results but no data have been published to date. We have treated an equine lid tumor with good results, and others are pursuing investigations in this area. Use of commercial hyperthermia instruments for treatment of any condition other than bovine cancer-eye or similar small tumors on animals cannot be justified. Like other therapeutic techniques, hyperthermia must be applied to appropriate cases and retreatment will be necessary in some instances. (ERB)

Doss, J.D.

1980-01-01T23:59:59.000Z

132

Motion-induced radiation from electrons moving in Maxwell's fish-eye  

E-Print Network (OSTI)

In \\u{C}erenkov radiation and transition radiation, evanescent wave from motion of charged particles transfers into radiation coherently. However, such dissipative motion-induced radiations require particles to move faster than light in medium or to encounter velocity transition to pump energy. Inspired by a method to detect cloak by observing radiation of a fast-moving electron bunch going through it by Zhang {\\itshape et al.}, we study the generation of electron-induced radiation from electrons' interaction with Maxwell's fish-eye sphere. Our calculation shows that the radiation is due to a combination of \\u{C}erenkov radiation and transition radiation, which may pave the way to investigate new schemes of transferring evanescent wave to radiation.

Liu, Yangjie

2013-01-01T23:59:59.000Z

133

Eye hazard and glint evaluation for the 5-MW/sub t/ Solar Thermal Test Facility  

DOE Green Energy (OSTI)

Potential eye hazards associated with concentrated reflected light are evaluated for the ERDA 5-MW/sub t/ Solar Thermal Test Facility to be constructed at Sandia Laboratories, Albuquerque, New Mexico. Light intensities and hazardous ranges of single and multiple coincident heliostat beams are evaluated at ground level and in the air space above the facility. Possible long-range and short-range effects of distractive effects of reflected beams are discussed. Also described are certain beam control modifications which were incorporated to minimize the altitudes at which overflying aircraft could encounter unsafe levels. Recommendations are made for further evaluation of intensity excursions during fail-safe shutdown situations, and for experiments to verify analytical models and to assess distractive glint effects.

Brumleve, T.D.

1977-05-01T23:59:59.000Z

134

Typhoon eye trajectory based on a mathematical model: comparing with observational data  

E-Print Network (OSTI)

We propose a model based on the primitive system of the Navier-Stokes equations in a bidimensional framework as the $l$ - plane approximation, which allows us to explain the variety of tracks of tropical cyclones (typhoons). Our idea is to construct special analytical solutions with a linear velocity profile for the Navier-Stokes systems. The evidence of the structure of linear velocity near the center of vortex can be proven by the observational data. We study solutions with the linear-velocity property for both barotropic and baroclinic cases and show that they follow the same equations in describing the trajectories of the typhoon eye at the equilibrium state (that relates to the conservative phase of the typhoon dynamics). Moreover, at the equilibrium state, the trajectories can be viewed as a superposition of two circular motions: one has period $2\\pi/l,$ the other one has period $2\\pi/b_0,$ where $l$ is the Coriolis parameter and $b_0$ is the height-averaged vorticity at the center of cyclone. Also, we compare our theoretical trajectories based on initial conditions from the flow with tracks obtained from the observational database. It is worth to mention that under certain conditions our results are still compatible with observational data although we did not truly consider the influence of steering effect. %Note that the %motion of the typhoon eye can not be totally determinated by initial %conditions due to the effect of ambient pressure field ("steering" %effect). Finally, we propose the parameter-adopting method so that one could correct the weather prediction in real time. Examples of our analysis and the use of parameter-adopting method for the historic trajectories are provided.

Olga S. Rozanova; Jui-Ling Yu; Chin-Kun Hu

2010-02-23T23:59:59.000Z

135

Performance of "Moth Eye" Anti-Reflective Coatings for Solar Cell Applications  

SciTech Connect

An inexpensive, effective anti-reflective coating (ARC) has been developed at the University of Florida to significantly enhance the absorption of light by silicon in solar cells. This coating has nano-scale features, and its microstructure mimics that of various night active insects (e.g. a moth's eye). It is a square array of pillars, each about 700 nm high and having a diameter of about 300 nm. Samples of silicon having this coating were exposed either to various combinations of either elevated temperature and humidity or to gamma irradiation ({sup 60}Co) at the Savannah River National Laboratory, or to a broad spectrum ultraviolet light and to a 532 nm laser light at the University of Florida. The anti-reflective properties of the coatings were unaffected by any of these environmental stresses, and the microstructure of the coating was also unaffected. In fact, the reflectivity of the gamma irradiated ARC became lower (advantageous for solar cell applications) at wavelengths between 400 and 1000 nm. These results show that this coating is robust and should be tested in actual systems exposed to either weather or a space environment. Structural details of the ARCs were studied to optimize their performance. Square arrays performed better than hexagonal arrays - the natural moth-eye coating is indeed a square array. The optimal depth of the templated nanopillars in the ARC was investigated. A wet etching technology for ARC formation was developed that would be less expensive and much faster than dry etching. Theoretical modeling revealed that dimple arrays should perform better than nipple arrays. A method of fabricating both dimple and nipple arrays having the same length was developed, and the dimple arrays performed better than the nipple arrays, in agreement with the modeling. The commercial viability of the technology is quite feasible, since the technology is scalable and inexpensive. This technology is also compatible with current industrial fabrication of solar cells.

Clark, E.; Kane, M.; Jiang, P.

2011-03-14T23:59:59.000Z

136

Performance of "Moth Eye" Anti-Reflective Coatings for Solar Cell Applications  

DOE Green Energy (OSTI)

An inexpensive, effective anti-reflective coating (ARC) has been developed at the University of Florida to significantly enhance the absorption of light by silicon in solar cells. This coating has nano-scale features, and its microstructure mimics that of various night active insects (e.g. a moth's eye). It is a square array of pillars, each about 700 nm high and having a diameter of about 300 nm. Samples of silicon having this coating were exposed either to various combinations of either elevated temperature and humidity or to gamma irradiation ({sup 60}Co) at the Savannah River National Laboratory, or to a broad spectrum ultraviolet light and to a 532 nm laser light at the University of Florida. The anti-reflective properties of the coatings were unaffected by any of these environmental stresses, and the microstructure of the coating was also unaffected. In fact, the reflectivity of the gamma irradiated ARC became lower (advantageous for solar cell applications) at wavelengths between 400 and 1000 nm. These results show that this coating is robust and should be tested in actual systems exposed to either weather or a space environment. Structural details of the ARCs were studied to optimize their performance. Square arrays performed better than hexagonal arrays - the natural moth-eye coating is indeed a square array. The optimal depth of the templated nanopillars in the ARC was investigated. A wet etching technology for ARC formation was developed that would be less expensive and much faster than dry etching. Theoretical modeling revealed that dimple arrays should perform better than nipple arrays. A method of fabricating both dimple and nipple arrays having the same length was developed, and the dimple arrays performed better than the nipple arrays, in agreement with the modeling. The commercial viability of the technology is quite feasible, since the technology is scalable and inexpensive. This technology is also compatible with current industrial fabrication of solar cells.

Clark, E.; Kane, M.; Jiang, P.

2011-03-14T23:59:59.000Z

137

A fully implantable intracochlear drug delivery device : development and characterization  

E-Print Network (OSTI)

In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

Swan, Erin Eileen Leary, 1976-

2009-01-01T23:59:59.000Z

138

Typhoon eye trajectory based on a mathematical model: comparing with observational data  

E-Print Network (OSTI)

We propose a model based on the primitive system of the Navier-Stokes equations in a bidimensional framework as the $l$ - plane approximation, which allows us to explain the variety of tracks of tropical cyclones (typhoons). Our idea is to construct special analytical solutions with a linear velocity profile for the Navier-Stokes systems. The evidence of the structure of linear velocity near the center of vortex can be proven by the observational data. We study solutions with the linear-velocity property for both barotropic and baroclinic cases and show that they follow the same equations in describing the trajectories of the typhoon eye at the equilibrium state (that relates to the conservative phase of the typhoon dynamics). Moreover, at the equilibrium state, the trajectories can be viewed as a superposition of two circular motions: one has period $2\\pi/l,$ the other one has period $2\\pi/b_0,$ where $l$ is the Coriolis parameter and $b_0$ is the height-averaged vorticity at the center of cyclone. Also, we ...

Rozanova, Olga S; Hu, Chin-Kun

2010-01-01T23:59:59.000Z

139

Simulating Dissolution of Intravitreal Triamcinolone Acetonide Suspensions in an Anatomically Accurate Rabbit Eye Model  

E-Print Network (OSTI)

Purpose A computational fluid dynamics (CFD) study examined the impact of particle size on dissolution rate and residence of intravitreal suspension depots of Triamcinolone Acetonide (TAC). Methods A model for the rabbit eye was constructed using insights from high-resolution NMR imaging studies (Sawada 2002). The current model was compared to other published simulations in its ability to predict clearance of various intravitreally injected materials. Suspension depots were constructed explicitly rendering individual particles in various configurations: 4 or 16 mg drug confined to a 100 ?L spherical depot, or 4 mg exploded to fill the entire vitreous. Particle size was reduced systematically in each configuration. The convective diffusion/ dissolution process was simulated using a multiphase model. Results Release rate became independent of particle diameter below a certain value. The size-independent limits occurred for particle diameters ranging from 77 to 428 ?M depending upon the depot configuration. Residence time predicted for the spherical depots in the size-independent limit was comparable to that observed in vivo. Conclusions Since the size-independent limit was several-fold greater than the particle size of commercially available

Paul J. Missel; Marc Horner; R. Muralikrishnan; P. J. Missel; M. Horner; R. Muralikrishnan

2010-01-01T23:59:59.000Z

140

The Dutch Elm Disease  

NLE Websites -- All DOE Office Websites (Extended Search)

Dutch Elm Disease Dutch Elm Disease Nature Bulletin No. 411-A March 20, 1971 Forest Preserve District of Cook County George W. Dunne, President Roland F. Eisenbeis, Supt. of Conservation THE DUTCH ELM DISEASE The American elm, far and away our most popular and important shade tree, is facing its most threatening enemy, the Dutch Elm Disease. A large part of them seem to be doomed unless up-to-date methods of control are used. In New England the appearance of whole towns has been changed by the loss of gigantic elms along entire streets. This same havoc is being repeated in most eastern states and, now, as far west as Missouri. The first diseased tree in Illinois was found downstate fifteen years ago. Since then, the infection has spread over most of the state, reaching the Chicago region in 1954.

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141

Emerging Steel Technologies, HotEye in Steel Rolling and Process Metrix Mobile Laser Contouring System (LCS) for Converter Lining Thickness Monitoring  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

OG OG (tm) HotEye HotEye ® ® in Steel Rolling in Steel Rolling - - About the HotEye HotEye ® ® RSB System RSB System Presented by OG Technologies, Inc. DOE Web Cast January 29, 2009 OG Technologies, Inc., 4300 Varsity Drive, Suite C, Ann Arbor, MI 48108, 734-973-7500, 734-973-1966(fax) Contact@ogtechnologies.com, www.ogtechnologies.com OG (tm) OG Technologies, Inc. OG Technologies, Inc. Mission: To substantially enhance the productivity of our steel customers by significantly improving process control and quality resulting in dramatic reduction scrap, energy costs and emissions through the application of our patented and proprietary technologies. OG Technologies, Inc., 4300 Varsity Drive, Suite C, Ann Arbor, MI 48108, 734-973-7500, 734-973-1966(fax) Contact@ogtechnologies.com, www.ogtechnologies.com

142

Lyme Disease Lyme Borreliosis,  

E-Print Network (OSTI)

Lyme disease is a tickborne illness that results from infection with members of the Borrelia burgdorferi sensu lato complex. These organisms are maintained in wild animals, but they can affect humans and some species of domesticated animals. Lyme disease was first recognized in the 1970s, when a cluster of juvenile arthritis cases was investigated in the U.S., but its symptoms can be found in European historical records as far back as the early 20th century. This disease has also been detected in Australia, parts of Asia, the province of Ontario, Canada, and recently, the Amazon region of Brazil. Lyme disease in people is readily cured with antibiotics during the initial stage of the illness, when an unusual rash often aids disease recognition. However, people whose infections remain untreated sometimes develop chronic arthritis, neurological signs and other syndromes. Lyme disease in domesticated animals is still poorly understood, and no distinctive rash seems to occur. The illness is best characterized in the dog, where arthritis and nephropathy appear to be the most common sequelae. Clinical signs attributed to Lyme disease have also been reported in other species including horses and cattle.

Lyme Arthritis; Erythema Migrans

2011-01-01T23:59:59.000Z

143

Severe Dry Eye Syndrome After Radiotherapy for Head-and-Neck Tumors  

Science Conference Proceedings (OSTI)

Purpose: To investigate the incidence of severe dry eye syndrome (DES) after external beam radiotherapy for head-and-neck cancer and its dependence on the parameters relevant to external beam radiotherapy. Methods and Materials: The present retrospective study included 78 patients treated for primary extracranial head-and-neck tumors between 1965 and 2000, whose lacrimal apparatus/entire globe was exposed to fractionated external beam radiotherapy. The dose received by the major lacrimal gland was used for analysis. The end point of the present study was the ophthalmologic diagnosis of severe DES leading to vision compromise. Results: Of the 78 patients, 40 developed severe DES leading to visual compromise. The incidence of DES increased steadily from 6% at 35-39.99 Gy to 50% at 45-49.99 Gy and 90% at 60-64.99 Gy. With a mean of 0.9 years (range, 1 month to 3 years), the latency of DES was observed to be a function of the total dose and the dose per fraction. On univariate and multivariate analysis, the total dose (p =}60 Gy. A logistic normal tissue complication probability model fit to our data obtained a dose of 34 and 38 Gy corresponding to a 5% and 10% incidence of DES. Conclusion: With a dose of 34 Gy corresponding to a 5% incidence of DES, the risk of severe DES increased, and the latency decreased with an increase in the total dose and dose per fraction to the lacrimal gland. The effect of chemoradiotherapy and hyperfractionation on the risk of DES needs additional investigation.

Bhandare, Niranjan, E-mail: bhandn@shands.ufl.edu [Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL (United States); Moiseenko, Vitali [Vancouver Cancer Centre, Vancouver, BC (Canada); Song, William Y. [University of California, San Diego, San Diego, CA (United States); Morris, Christopher G. [Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL (United States); Bhatti, M. Tariq [Department of Ophthalmology and Medicine (Division of Neurology), Duke University Medical Center, Durham, NC (United States); Mendenhall, William M. [Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL (United States)

2012-03-15T23:59:59.000Z

144

Multimedia Resources, including the CMS Eye, from the Compact Muon Solenoid (CMS) Experiment at CERN  

DOE Data Explorer (OSTI)

The Compact Muon Solenoid (CMS) experiment is one of two large general-purpose particle physics detectors built on the proton-proton Large Hadron Collider (LHC) at CERN in Switzerland and France. The CMS detector is located in an underground cavern at Cessy in France. The CMS detector will study many aspects of proton collisions at 14 TeV, the center-of-mass energy of the LHC particle accelerator. [from http://en.wikipedia.org/wiki/Compact_Muon_Solenoid]

The US CMS collaboration, with 48 institutions, 420 Ph.D. physicists, over 100 graduate students, and nearly 200 engineers, technicians, and computer scientists is the largest national group in the CMS collaboration. US groups have made significant contributions to nearly every aspect of the detector throughout all phases including construction, installation and preparation for data-taking. The US collaboration also made major contributions to the construction and operation of the computing facilities needed to analyze the unprecedented amount of data to be generated by CMS. This work includes the software that allows physicists to operate the CMS detector, reconstruct the data, analyze it and extract new physics.

The CMS media website from CERN provides images, videos, presentations, and the CMS Eye, a system of webcams looking into the underground cavern at Cessy, into the control room, and even out of the window of the control room at the village of Cessy and the Jura Mountains. Many event displays are available in the image collections, as well as the CMS Photo Book covering 1998 2008 when CMS was being assembled, installed, and commissioned.

US-LHC and the International CMS Collaboration

145

Ticks and Human Diseases  

NLE Websites -- All DOE Office Websites (Extended Search)

species: principally the Rocky Mountain Wood Tick in the west, and the American Dog Tick here and in eastern states. Tularemia, or rabbit fever, is a disease which is...

146

Dogs and Human Diseases  

NLE Websites -- All DOE Office Websites (Extended Search)

Diseases Name: Doris Status: Other Grade: 9-12 Location: OK Date: NA Question: Can a dog contact the shingles or chicken pox virus from a human? Replies: Hi Doris, Great...

147

Combining Image and Non-Image Data for Automatic Detection of Retina Disease in a Telemedicine Network  

SciTech Connect

A telemedicine network with retina cameras and automated quality control, physiological feature location, and lesion/anomaly detection is a low-cost way of achieving broad-based screening for diabetic retinopathy (DR) and other eye diseases. In the process of a routine eye-screening examination, other non-image data is often available which may be useful in automated diagnosis of disease. In this work, we report on the results of combining this non-image data with image data, using the protocol and processing steps of a prototype system for automated disease diagnosis of retina examinations from a telemedicine network. The system includes quality assessments, automated physiology detection, and automated lesion detection to create an archive of known cases. Non-image data such as diabetes onset date and hemoglobin A1c (HgA1c) for each patient examination are included as well, and the system is used to create a content-based image retrieval engine capable of automated diagnosis of disease into 'normal' and 'abnormal' categories. The system achieves a sensitivity and specificity of 91.2% and 71.6% using hold-one-out validation testing.

Aykac, Deniz [ORNL; Chaum, Edward [University of Tennessee, Knoxville (UTK); Fox, Karen [Delta Health Alliance; Garg, Seema [University of North Carolina; Giancardo, Luca [ORNL; Karnowski, Thomas Paul [ORNL; Li, Yaquin [University of Tennessee, Knoxville (UTK); Nichols, Trent L [ORNL; Tobin Jr, Kenneth William [ORNL

2011-01-01T23:59:59.000Z

148

A Fast Algorithm for Eye Detection Using Two-Dimensional CSP Akiko SUZUKI Tetsuya TAKIGUCHI Yasuo ARIKI  

E-Print Network (OSTI)

CSP A Fast Algorithm for Eye Detection Using Two-Dimensional CSP Akiko SUZUKI Tetsuya TAKIGUCHI Yasuo ARIKI 1. , CSP Crosspower-Spectrum Phase 2 [1] [2][3] CSP 2. W ? H I(x, y) w ? h T(i, j) R(x, y) R(x, y) (4) 3. CSP 1 CSP I(x, y) T(i, j) I(1, 2) = x,y I(x, y)e-j1x e-j2y (5) T(1, 2) = i,j T(i, j)e-j1

Takiguchi, Tetsuya

149

BEDVH--A method for evaluating biologically effective dose volume histograms: Application to eye plaque brachytherapy implants  

Science Conference Proceedings (OSTI)

Purpose: A method is introduced to examine the influence of implant duration T, radionuclide, and radiobiological parameters on the biologically effective dose (BED) throughout the entire volume of regions of interest for episcleral brachytherapy using available radionuclides. This method is employed to evaluate a particular eye plaque brachytherapy implant in a radiobiological context. Methods: A reference eye geometry and 16 mm COMS eye plaque loaded with {sup 103}Pd, {sup 125}I, or {sup 131}Cs sources were examined with dose distributions accounting for plaque heterogeneities. For a standardized 7 day implant, doses to 90% of the tumor volume ( {sub TUMOR}D{sub 90}) and 10% of the organ at risk volumes ( {sub OAR}D{sub 10}) were calculated. The BED equation from Dale and Jones and published {alpha}/{beta} and {mu} parameters were incorporated with dose volume histograms (DVHs) for various T values such as T = 7 days (i.e., {sub TUMOR} {sup 7}BED{sub 10} and {sub OAR} {sup 7}BED{sub 10}). By calculating BED throughout the volumes, biologically effective dose volume histograms (BEDVHs) were developed for tumor and OARs. Influence of T, radionuclide choice, and radiobiological parameters on {sub TUMOR}BEDVH and {sub OAR}BEDVH were examined. The nominal dose was scaled for shorter implants to achieve biological equivalence. Results: {sub TUMOR}D{sub 90} values were 102, 112, and 110 Gy for {sup 103}Pd, {sup 125}I, and {sup 131}Cs, respectively. Corresponding {sub TUMOR} {sup 7}BED{sub 10} values were 124, 140, and 138 Gy, respectively. As T decreased from 7 to 0.01 days, the isobiologically effective prescription dose decreased by a factor of three. As expected, {sub TUMOR} {sup 7}BEDVH did not significantly change as a function of radionuclide half-life but varied by 10% due to radionuclide dose distribution. Variations in reported radiobiological parameters caused {sub TUMOR} {sup 7}BED{sub 10} to deviate by up to 46%. Over the range of {sub OAR}{alpha}/{beta} values, {sub OAR} {sup 7}BED{sub 10} varied by up to 41%, 3.1%, and 1.4% for the lens, optic nerve, and lacrimal gland, respectively. Conclusions: BEDVH permits evaluation of the relative biological effectiveness for brachytherapy implants. For eye plaques, {sub TUMOR}BEDVH and {sub OAR}BEDVH were sensitive to implant duration, which may be manipulated to affect outcomes.

Gagne, Nolan L.; Leonard, Kara L.; Huber, Kathryn E.; Mignano, John E.; Duker, Jay S.; Laver, Nora V.; Rivard, Mark J. [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States); Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States); Departments of Ophthalmology and Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States); Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States)

2012-02-15T23:59:59.000Z

150

Method and system for the diagnosis of disease using retinal image content and an archive of diagnosed human patient data  

DOE Patents (OSTI)

A method for diagnosing diseases having retinal manifestations including retinal pathologies includes the steps of providing a CBIR system including an archive of stored digital retinal photography images and diagnosed patient data corresponding to the retinal photography images, the stored images each indexed in a CBIR database using a plurality of feature vectors, the feature vectors corresponding to distinct descriptive characteristics of the stored images. A query image of the retina of a patient is obtained. Using image processing, regions or structures in the query image are identified. The regions or structures are then described using the plurality of feature vectors. At least one relevant stored image from the archive based on similarity to the regions or structures is retrieved, and an eye disease or a disease having retinal manifestations in the patient is diagnosed based on the diagnosed patient data associated with the relevant stored image(s).

Tobin, Kenneth W; Karnowski, Thomas P; Chaum, Edward

2013-08-06T23:59:59.000Z

151

Lens of Eye Dose Limit Changes: Current Status of the Potential Regulatory Changes and Possible Effects on Radiation Protection Programs at Nuclear Power Plants  

Science Conference Proceedings (OSTI)

Recent research suggests that the threshold for cataract formation as a result of exposure to radiation could be lower than previously considered. The International Commission on Radiological Protection (ICRP) is now recommending a dose limit for the lens of the eye of an average of 20 mSv (2 rem) per year, equivalent to their current recommendation for Total Effective Dose Equivalent (TEDE). The Nuclear Regulatory Commission (NRC) is considering reducing the lens of the eye dose limit to 50 mSv/yr ...

2013-10-29T23:59:59.000Z

152

Web Sites about Infectious Disease Web Sites about Infectious Disease  

E-Print Network (OSTI)

Web Sites about Infectious Disease Web Sites about Infectious Disease Stanford Center for Tuberculosis Research-Site Links http://molepi.stanford.edu/tblinks.html Virology on the World Wide Web http://www.idsociety.org/ file:///C|/Program%20Files/Adobe/Adobe%20Dreamweav...nks/Web%20Sites%20about%20Infectious%20Disease

de Lijser, Peter

153

2011 Special Issue: Modeling eye movements in visual agnosia with a saliency map approach: Bottom-up guidance or top-down strategy?  

Science Conference Proceedings (OSTI)

Two recent papers (Foulsham, Barton, Kingstone, Dewhurst, & Underwood, 2009; Mannan, Kennard, & Husain, 2009) report that neuropsychological patients with a profound object recognition problem (visual agnosic subjects) show differences from healthy observers ... Keywords: Eye movements, Neuropsychology, Object recognition, Visual attention, Visual saliency

Tom Foulsham; Jason J. S. Barton; Alan Kingstone; Richard Dewhurst; Geoffrey Underwood

2011-08-01T23:59:59.000Z

154

Observations of Atmospheric Structure and Dynamics in the Owens Valley of California with a Ground-Based, Eye-Safe, Scanning Aerosol Lidar  

Science Conference Proceedings (OSTI)

First results are presented from the deployment of the NCAR Raman-Shifted Eye-Safe Aerosol Lidar (REAL) in the Owens Valley of California during the Terrain-Induced Rotor Experiment (T-REX) in March and April 2006. REAL operated in rangeheight ...

Stephan F. J. De Wekker; Shane D. Mayor

2009-07-01T23:59:59.000Z

155

Genetics of motor neuron disease  

Science Conference Proceedings (OSTI)

The number of genes associated with motor neuron degen- eration has increased ... Motor neurons are affected in a large number of neurologic diseases

156

Differentiating Lyme Disease from Syphilis  

E-Print Network (OSTI)

Analysis of the humoral response to the flagellin protein of Borrelia burgdorferi: cloning of regions capable of differentiating Lyme disease from syphilis.

J M Robinson; T J Pilot-matias; S D Pratt; C B Patel; T S Bevirt; J C Hunt; J. Clin Microbiol; Terry S. Bevirt; J. C. Hunt

1992-01-01T23:59:59.000Z

157

Development and Deployment of a Compact Eye-safe Scanning Differential Absorption Lidar (DIAL) for Spatial Mapping of Carbon Dioxide for MVA at Geologic Carbon Sequestration Sites  

NLE Websites -- All DOE Office Websites (Extended Search)

Deployment of a Deployment of a Compact Eye-safe Scanning Differential Absorption Lidar (DIAL) for Spatial Mapping of Carbon Dioxide for MVA at Geologic Carbon Sequestration Sites Description Through its core research and development program administered by the National Energy Technology Laboratory (NETL), the U.S. Department of Energy (DOE) emphasizes monitoring, verification, and accounting (MVA), as well as computer simulation, of possible carbon dioxide (CO 2 ) leakage at CO 2

158

Choline, Phospholipids, Health, and Disease  

Science Conference Proceedings (OSTI)

The proceedings of the 7th International Congress on Phospholipids. Choline, Phospholipids, Health, and Disease Health acid analysis aocs april articles chloropropanediol contaminants detergents dietary fats division divisions esters fats fatty food food

159

VoIP Panacea or PIG's Ear?  

Science Conference Proceedings (OSTI)

Voice over IP (VoIP) hit the headlines during the mid-1990s amid claims concerning its potential impact upon existing switched-circuit telephony services. While VoIP has provided a focus for much debate within the industry, there has been a clear gulf ...

R. P. Swale

2001-04-01T23:59:59.000Z

160

Dietary Fats and Risk of Chronic Disease  

Science Conference Proceedings (OSTI)

Dietary Fats will cover the effect of different dietary fats on the development of chronic diseases, such as cardiovascular disease, diabetes, cancers, inflammation, and immune functions. ...

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Neurological Findings of Lyme Disease  

E-Print Network (OSTI)

Neurologic involvement of Lyme disease typically consists of meningitis, cranial neuropathy, and radiculoneuritis, alone or in combination, lasting for months. From 1976 to 1983, we studied 38 patients with Lyme meningitis. Headache and mild neck stiffness, which fluctuated in intensity, and lymphocytic pleocytosis were the common findings. Half of the patients also had facial palsies, which were unilateral in 12 and bilateral in seven. In addition, 12 patients had motor and/or sensory radiculoneuropathies; asymmetric weakness of extremities was the most common finding. Although incomplete presentations of neurologic involvement of Lyme disease may be confused with other entities, the typical constellation of neurologic symptoms represents a unique clinical picture. Three major types of lesions comprise the neurological manifestations of Lyme disease: meningitis, cranial neuropathy, and radiculoneuritis [1]. These three may occur alone or in combination (Fig. 1). In this report, we describe thirty-eight patients who had meningitis sometimes accompanied by cranial neuropathy and/or peripheral radiculoneuropathy, as reported in depth elsewhere [2]. We believe that this constellation of symptoms is unique among neurological diseases.

Andrew R. Pachner; Allen C. Steere

1983-01-01T23:59:59.000Z

162

math_patterns.html  

NLE Websites -- All DOE Office Websites (Extended Search)

musical scale is based upon the ratios of 1:2, 1:3, 1:4, etc. The Parthenon of ancient Greece is designed with these very ratios, which are pleasing to the eye and to the ear. The...

163

Chronic disease management: a business intelligence perspective  

Science Conference Proceedings (OSTI)

Chronic disease management is one of the main areas in healthcare that Health Knowledge Management (HKM) can provide beneficial outcomes. Information Communication Technology (ICT) enabled Chronic disease management network (cdmNet) delivers comprehensive ... Keywords: business intelligence, chronic disease management, data mining

Leelani Kumari Wickramasinghe, Damminda Alahakoon, Michael Georgeff, Peter Schattner, Daswin De Silva, Oshadi Alahakoon, Akuh Adaji, Kay Jones, Am Leon Piterman

2011-01-01T23:59:59.000Z

164

Coronary Heart Disease, Hypertension, Stroke, and  

E-Print Network (OSTI)

Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart · Disease process: coronary and arms Myocardial infarction - heart attack, ischemia - local blood supply decreased resulting in cell

Meagher, Mary

165

Epidemiology and Control of Infectious Diseases of Salmonids in the Columbia River Basin, 1983 Annual Report.  

DOE Green Energy (OSTI)

The Department of Microbiology at Oregon State University with funding from the Bonneville Power Administration conducted a study relating to the epidemiology and control of three fish diseases of salmonids in the Columbia River Basin. These three diseases were ceratomyxosis which is caused by the myxosporidan parasite Ceratomyxa shasta, bacterial kidney disease, the etiological agent of which is Renibacterium salmoninarum, and infectious hematopoietic necrosis, which is caused by a rhabdovirus. Each of these diseases is highly destructive and difficult or impossible to treat with antimicrobial agents. The presence of ceratomyxosis in rainbow trout exposed at McNary and Little Goose Dams extends the range of this disease about 200 miles further up the Columbia River and into the Snake River drainage. Wallowa steelhead trout were less resistant to this disease than other upriver stocks tested. Juvenile salmonids entering the Columbia River estuary were collected periodically between May to September, 1983. Nine percent of the beach seined chinook salmon and 5, 11 and 12%, respectively, of the purse seined coho and chinook salmon and steelhead trout were infected with Ceratomyxa shasta. Experiments indicated ceratomyxosis progresses in salt water at the same rate as in fresh water once the fish have become infected. These data indicate a longer exposure to infective stages of C. shasta than previously identified and that approximately 10% of the migrating salmonids are infected and will probably die from this organism after entering salt water. Since sampling began in 1981 the bacterial kidney disease organism, Renibacterium salmoninarum, has been detected by the fluorescent antibody test in seven salmonid species caught in the open ocean off the coasts of Washington and Oregon. The bacterium has been found primarily in chinook salmon (11%) with lesions in 2.5% of these fish. This disease was also detected at levels ranging from 17% in coho salmon to 25% in chinook salmon seined from the Columbia River just before entering the estuary. Interpretation of these numbers suggests an even greater economic impact on Columbia River salmonid stocks than that proposed for C. shasta. Fertilized eggs from bacterial kidney disease infected parents examined after one month of incubation revealed the presence of bacteria with identical morphology to R. salmoninarum on or in the egg wall further reinforcing the proposed vertical transmission of this disease organism. Infectious hematopoietic necrosis virus was recovered at the 67% level from seeded water samples supplemented with 1% fetal calf serum. Virus injected into unfertilized eggs survived for over two weeks; in eyed eggs the virus also replicated. Epizootics caused by IHNV occurred in two of the 8 separate groups of steelhead trout fingerlings held in LJV treated water at Round Butte Hatchery. Comparing these results to those in the vertical transmission experiment where none of the groups developed IHNV suggests that vertical transmission of IHNV, if it occurs, is a very infrequent or random event. On three occasions IHNV was detected in ovarian fluid samples after storage for 6--9 days at 4 C. No virus had been detected in these samples at spawning. This suggests the presence of an interfering substance, perhaps anti-IHNV antibody in ovarian fluid. This observation raises the possibility that IHNV is much more widespread throughout Columbia River Basin salmonid stocks than previously believed.

Fryer, John L.

1984-11-01T23:59:59.000Z

166

Investigations of Altered Aquatic Ecosystems: Biomonitoring, Disease, and Conservation  

E-Print Network (OSTI)

removal of lizards on Lyme disease risk. Proceedings of thereservoirs intervenes in the Lyme disease cycle. Proceedings

Lunde, Kevin Bryce

2011-01-01T23:59:59.000Z

167

Cellular Immune Findings in Lyme Disease  

E-Print Network (OSTI)

From 1981 through 1983, we did the first testing of cellular immunity in Lyme disease. Active established Lyme disease was often associated with lymphopenia, less spontaneous suppressor cell activity than normal, and a heightened response of lymphocytes to phytohemagglutinin and Lyme spirochetal antigens. Thus, a major feature of the immune response during active disease seems to be a lessening of suppression, but it is not yet known whether this response plays a role in the pathophysiology of the disease. Lyme disease, a tick-borne spirochetosis [1], is associated with characteristic immune findings. Elevated serum IgM levels in patients with active erythema chronicum migrans (ECM) predict subsequent nervous system, heart, or joint involvement, and serial determinations of IgM are generally the best laboratory indicator of disease activity [2]. In addition, patients with nervous system or joint abnormalities have an increased frequency of the B-cell alloantigen, DR2 [3]. During the last three summers, from 1981 through 1983, we performed the first tests of cellular immunity in Lyme disease. We report here that active Lyme disease is often associated with lymphopenia, less spontaneous suppressor cell activity than normal,

Leonard H. Sigal; Craig M. Moffat; Allen C. Steere; John; M. Dwyer, Ph.D.

1984-01-01T23:59:59.000Z

168

A DETAILED MORPHO-KINEMATIC MODEL OF THE ESKIMO, NGC 2392: A UNIFYING VIEW WITH THE CAT'S EYE AND SATURN PLANETARY NEBULAE  

Science Conference Proceedings (OSTI)

The three-dimensional and kinematic structure of the Eskimo nebula, NGC 2392, has been notoriously difficult to interpret in detail given its complex morphology, multiple kinematic components and its nearly pole-on orientation along the line of sight. We present a comprehensive, spatially resolved, high-resolution, long-slit spectroscopic mapping of the Eskimo planetary nebula. The data consist of 21 spatially resolved, long-slit echelle spectra tightly spaced over the Eskimo and along its bipolar jets. This data set allows us to construct a velocity-resolved [N II] channel map of the nebula with a resolution of 10 km s{sup -1} that disentangles its different kinematic components. The spectroscopic information is combined with Hubble Space Telescope images to construct a detailed three-dimensional morpho-kinematic model of the Eskimo using the code SHAPE. With this model we demonstrate that the Eskimo is a close analog to the Saturn and the Cat's Eye nebulae, but rotated 90 Degree-Sign to the line of sight. Furthermore, we show that the main characteristics of our model apply to the general properties of the group of elliptical planetary nebulae with ansae or FLIERS, once the orientation is considered. We conclude that this kind of nebula belongs to a class with a complex common evolutionary sequence of events.

Garcia-Diaz, Ma. T.; Lopez, J. A.; Steffen, W.; Richer, M. G., E-mail: tere@astrosen.unam.mx, E-mail: jal@astrosen.unam.mx, E-mail: wsteffen@astrosen.unam.mx, E-mail: richer@astrosen.unam.mx [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Campus Ensenada, Ensenada, Baja California, 22800 (Mexico)

2012-12-20T23:59:59.000Z

169

LOOKING DEEP INTO THE CAT'S EYE: STRUCTURE AND ROTATION IN THE FAST WIND OF THE PN CENTRAL STAR OF NGC 6543  

SciTech Connect

We present HST/STIS time-series spectroscopy of the central star of the 'Cat's Eye' planetary nebula NGC 6543. Intensive monitoring of the UV lines over a 5.8 hr period reveals well-defined details of large-scale structure in the fast wind, which are exploited to provide new constraints on the rotation rate of the central star. We derive characteristics of the line profile variability that support a physical origin due to corotating interaction regions (CIRs) that are rooted at the stellar surface. The recurrence time of the observed spectral signatures of the CIRs is used to estimate the rotation period of the central star and, adopting a radius between 0.3 and 0.6 R{sub Sun} constrains the rotational velocity to the range 54 km s{sup -1} {<=} v{sub rot} {<=} 108 km s{sup -1}. The implications of these results for single star evolution are discussed based on models calculated here for low-mass stars. Our models predict a subsurface convective layer in NGC 6543 which we argue to be causally connected to the occurrence of structure in the fast wind.

Prinja, R. K. [Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT (United Kingdom); Massa, D. L. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Cantiello, M. [Kavli Institute for Theoretical Physics, University of California Santa Barbara, CA 93106 (United States)

2012-11-10T23:59:59.000Z

170

Author manuscript, published in "The Sixth International Conference on Wireless On-demand Network Systems and Services (2009)" DOI: 10.1109/WONS.2009.4801855 Loop Avoidance for Fish-Eye OLSR in Sparse Wireless Mesh Networks  

E-Print Network (OSTI)

Abstract The use of Fish eye scoping has been introduced to reduce the overhead of the OLSR routing protocol. This simple method is based on reducing the scope (TTL) of some topology updates, thus giving routers a precise view of their close neighborhood and a more and more approximate view of farther nodes. Fish Eye OLSR (OFLSR) has been showed to have excellent scaling properties and low network overhead. However, if deployed in relatively sparse networks, this scoping limitation of topology updates can result in long living routing loops, thus limiting the potential applications of such mechanisms in some practical wireless mesh networks. In this paper, we address the transient mini-loop problem due to fisheye scoping. We first analyze the occurrence of mini-loops. We discuss potential solutions and propose a pragmatic and distributed off-line heuristic, which allows each router to

Yasir Faheem

2010-01-01T23:59:59.000Z

171

Cat-scratch disease simulating lyphoma  

SciTech Connect

Cat-scratch disease is the most common cause of benign lymphadenopathy in children and young adults. Rare cases of systemic involvement with deep adenopathy with or without hepatic and/or splenic involvement have been reported. We present an unusual case of cat-scratch disease with imaging findings indistinguishable from lymphoma. Cat-scratch disease should be considered as a possible benign etiology for adenopathy with hepatic or splenic nodules in a young patient, especially if the involved nodes are tender. 5 refs., 1 fig.

Wong, T.Z.; Kruskal, J.; Kane, R.A.; Trey, G. [Harvard Medical School, Boston, MA (United States)

1996-01-01T23:59:59.000Z

172

REVEALING HEREDITARY DISEASES p.6 SLU GOES GLOBAL p.21  

E-Print Network (OSTI)

the transmission of infectious disease to humans, particularly vectorborne diseases such as malaria and Lyme that suggest increasing rates of Borrelia burgdorferi tick infection, the pathogen associated with Lyme disease disease: effects of host diversity and community composition on Lyme disease risk. Proceedings

173

Visualizing Brain Metals in Health and Disease  

NLE Websites -- All DOE Office Websites (Extended Search)

Visualizing Brain Metals in Health and Visualizing Brain Metals in Health and Disease figure 1 Fig. 1. Rapid-scanning x-ray fluorescence mapping ex perimental setup. Synchrotron x-rays at 11 keV passed through a 50 µm aperture (Ap). The beam intensity was monitored with a N2-filled ion chamber (I0). The brain slice was mounted vertically on a motorized stage (St) at 45° to the incident x-ray beam and raster scanned in the beam. A 13-element Ge detector (Ge) was positioned at a 90° angle to the beam. We all require iron, copper and zinc for normal brain function but metal metabolism becomes dysregulated in a variety of neurodegenerative diseases. Metals accumulate in Alzheimer's dementia and Parkinson's disease and are deficient in Menkes disease. Whether excess metals appear as a cause or a

174

Ultraviolet Germicidal Irradiation for Preventing Infectious Disease  

NLE Websites -- All DOE Office Websites (Extended Search)

Ultraviolet Germicidal Irradiation for Preventing Infectious Disease Ultraviolet Germicidal Irradiation for Preventing Infectious Disease Transmission Speaker(s): Peng Xu Date: February 19, 2002 - 12:00pm Location: Bldg. 90 The transmission of tuberculosis (TB) and other infectious diseases in health-care buildings has been a recognized hazard for decades. Ultraviolet germicidal irradiation (UVGI) of upper room air is used as an engineering control method to prevent the spread of airborne infectious disease. Under full-scale conditions, the efficacy of UVGI for inactivating airborne bacterial spores and active cells was evaluated. A test room fitted with a modern UVGI system was used to conduct bio-aerosol inactivation experiments. UVGI efficacy can be affected by environmental factors such as relative humidity (RH), and air mixing

175

Metabolic Prosthesis for Treating Ischemic Diseases  

ORNL researchers have developed a new approach for treating ischemic diseases that will deliver oxygen directly to affected tissues by electrolysis of body fluids. Numerous treatments currently exist or have been proposed for treating ischemic ...

176

National Eye Institute, National Institutes of Health Healthy Eyes Bulletin  

E-Print Network (OSTI)

eating fish high in omega-3 fatty acids, such as salmon, tuna, and halibut. Maintain a healthy weight purchasing sunglasses, look for ones that block out 99 to 100 percent of both UV-A and UV-B radiation. Give

Bandettini, Peter A.

177

The Mediterranean Diet: A Protective Effect on Coronary Heart Disease  

E-Print Network (OSTI)

of Death and Coronary Heart Disease. Cambridge, Mass:the epidemiology of coronary heart disease. JAMA. 1957;164:and long-term coronary heart disease mortality in different

Paravar, Tara

2005-01-01T23:59:59.000Z

178

Behavioral impulsivity and hallucinations : insights from Parkinson's disease  

E-Print Network (OSTI)

Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

Ashourian, Paymon

2011-01-01T23:59:59.000Z

179

Women and Heart Disease Fact Sheet Facts on Women and Heart Disease  

E-Print Network (OSTI)

? Heart disease is the leading cause of death for women in the United States. In 2006, 315,930 women died from it. 1 ? Heart disease killed 26 % of the women who died in 2006more than one in every four. 1 Although heart disease is sometimes thought of as a "man's disease, " around the same number of women and men die each year of heart disease in the United States. Unfortunately, 36 % of women did not perceive themselves to be at risk for heart disease in a 2005 survey. 2 Heart disease is the leading cause of death for women of most racial/ethnic groups in the United States, including African Americans, American Indians or Alaska Natives, Hispanics, and whites. For Asian American women, heart disease is second only to cancer. 3 In 2006, about 6.9 % of all white women, 8.8 % of black women, and 6.6 % of Mexican American women were living with coronary heart disease. 4

unknown authors

2010-01-01T23:59:59.000Z

180

Chronic Beryllium Disease Awareness Card and Web Site  

NLE Websites -- All DOE Office Websites (Extended Search)

Chronic Beryllium Disease Awareness Card and Web Site Chronic Beryllium Disease Awareness The U.S Department of Energy's (DOE) Office of Health, Safety and Security (HSS) has...

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Global climate change and infectious diseases  

Science Conference Proceedings (OSTI)

The effects of global climate change on infectious diseases are hypothetical until more is known about the degree of change in temperature and humidity that will occur. Diseases most likely to increase in their distribution and severity have three-factor (agent, vector, and human being) and four-factor (plus vertebrate reservoir host) ecology. Aedes aegypti and Aedes albopictus mosquitoes may move northward and have more rapid metamorphosis with global warming. These mosquitoes transmit dengue virus, and Aedes aegypti transmits yellow fever virus. The faster metamorphosis and a shorter extrinsic incubation of dengue and yellow fever viruses could lead to epidemics in North America. Vibrio cholera is harbored persistently in the estuaries of the U.S. Gulf Coast. Over the past 200 years, cholera has become pandemic seven times with spread from Asia to Europe, Africa, and North America. Global warming may lead to changes in water ecology that could enhance similar spread of cholera in North America. Some other infectious diseases such as LaCrosse encephalitis and Lyme disease are caused by agents closely dependent on the integrity of their environment. These diseases may become less prominent with global warming because of anticipated modification of their habitats. Ecological studies will help as to understand more fully the possible consequences of global warming. New and more effective methods for control of vectors will be needed. 12 refs., 1 tab.

Shope, R. (Yale Univ. School of Medicine, New Haven, CT (United States))

1991-12-01T23:59:59.000Z

182

Plague Histeria: A Historical Perspective Of The Neurological Component Of Infectious Disease  

E-Print Network (OSTI)

and Jennifer A. Nields. 1994. Lyme disease: a neuropsy-of neurolog- ical disease. Lyme disease is a very common

Arnell, Monica

2011-01-01T23:59:59.000Z

183

Neural networks for longitudinal studies in Alzheimer's disease  

Science Conference Proceedings (OSTI)

Objective: Alzheimer's disease affects a growing population of elderly people today. The predictions about the course of the disease is a key component of health care decision making for patients with Alzheimer's. The physician's prognosis and predicted ... Keywords: Disease course, Longitudinal, Misclassification, Mixed effects, Neurodegenerative diseases, Prognosis, Random effects

Reeti Tandon; Sudeshna Adak; Jeffrey A. Kaye

2006-03-01T23:59:59.000Z

184

A Computational Model of Mitigating Disease Spread in Spatial Networks  

Science Conference Proceedings (OSTI)

This study examines the problem of disease spreading and containment in spatial networks, where the computational model is capable of detecting disease progression to initiate processes mitigating infection spreads. This paper focuses on disease spread ... Keywords: Computational Epidemiology, Computer Viruses, Disease Progression, Forest Fires, Spatial Networks

Taehyong Kim; Kang Li; Aidong Zhang; Surajit Sen; Murali Ramanathan

2011-04-01T23:59:59.000Z

185

Chemicals for Plant Disease Control at Home  

E-Print Network (OSTI)

This publication helps retailers and consumers identify products that control plant diseases. To clear up confusion about the names of the chemicals, the publication cross-references their common names with their chemical terms. It also lists the products commonly available in Texas retail stores and the companies that sell fungicides in small packages for homeowners.

Ong, Kevin

2007-10-30T23:59:59.000Z

186

Gallium-positive Lyme disease myocarditis  

Science Conference Proceedings (OSTI)

In the course of a work-up for fever of unknown origin associated with intermittent arrhythmias, a gallium scan was performed which revealed diffuse myocardial uptake. The diagnosis of Lyme disease myocarditis subsequently was confirmed by serologic titers. One month following recovery from the acute illness, the abnormal myocardial uptake completely resolved.

Alpert, L.I.; Welch, P.; Fisher, N.

1985-09-01T23:59:59.000Z

187

Lyme disease in an experimental mouse model  

E-Print Network (OSTI)

This research was directed at developing a murine model for the investigation of Lyme disease. This study sought to define the route of inoculation necessary to establish infection or disease in susceptible C3H/HeJ mice and also, to determine the virulence of four Borrelia burgdorferi isolates. Further, the influence of MHC Class I and Class 11 genes of the mouse H-2 complex on the susceptibility and/or resistance to Lyme disease was studied. This thesis demonstrates the development of multisysternic infection in the mouse model, namely, dermatological, cardiac, and arthritic lesions in C3HJHeJ mouse. It also demonstrates the involvement of Class I genes (K and D regions) and Class 11 genes (I-A and I-E regions) of the mouse H-2 complex on the quantitative antibody titers. This was achieved by using genetically stable B IO congenic and recombinant strains. The data presented in this thesis strongly supports use of C3HJHeJ and BIO congenic and recombinant strains as potential laboratory animal models for Lyme disease research.

Reddy, Sunitha

1993-01-01T23:59:59.000Z

188

Treatment of Anthrax Disease Frequently Asked Questions  

SciTech Connect

This document provides a summary of Frequently Asked Questions (FAQs) on the treatment of anthrax disease caused by a wide-area release of Bacillus anthracis spores as an act bioterrorism. These FAQs are intended to provide the public health and medical community, as well as others, with guidance and communications to support the response and long-term recovery from an anthrax event.

Judd, Kathleen S.; Young, Joan E.; Lesperance, Ann M.; Malone, John D.

2010-05-14T23:59:59.000Z

189

Review Lyme disease and current aspects of immunization  

E-Print Network (OSTI)

Lyme disease is a tick-borne multisystem disease that affects primarily the skin, nervous system, heart and joints. At least three species of Borrelia burgdorferi sensu lato, namely Borrelia burgdorferi sensu stricto, Borrelia garinii, and Borrelia afzelii, can cause the disease. This review will focus mainly on the pathophysiology of Lyme arthritis, the long-term outcome of Lyme disease, and the recently licensed vaccine against Lyme disease.

Thomas Kamradt

2001-01-01T23:59:59.000Z

190

ENGINEERING comBINEd yEARS of ENGINEERING  

E-Print Network (OSTI)

, university budget cuts have led to the closing of our Department of Industrial and Management Systems." Assistant professor Mahmoud Alahmad, who teaches electrical system design for the built environment with UNL/isolated approach to segments of the energy system in the house," Alahmad said. "The I-SAVE system allows for non

Farritor, Shane

191

DUF6 Managment Engineering Analysis Report (EAR) Summary  

NLE Websites -- All DOE Office Websites (Extended Search)

gas is corrosive. To neutralize it, or make it harmless, lime would be added, forming calcium fluoride (CaF ). The analysis assumes that the cleaned, emptied cylinders will be...

192

SLAC National Accelerator Laboratory - An Ear for Science: The...  

NLE Websites -- All DOE Office Websites (Extended Search)

and they are very small. As a result, Bellis inhabits a world of visualizations. Animations, graphs, computer-drawn images, Bellis uses them all to try to picture the scene...

193

"Falling upon deaf ears" : the case of colloquial architecture  

E-Print Network (OSTI)

World War II had instigated a strong national movement in The Middle East. In the Fifties and Sixties this region witnessed the end of colonialism in wide spread revolutions. The predominantly agrarian societies of The ...

Mejel, Jalal B. (Jalal Bezee)

1990-01-01T23:59:59.000Z

194

Music to our ears During a visit to Santa  

E-Print Network (OSTI)

Lynn M. Stegner Porter '78 Shelburne, Vermont A Foundation for the Future The UC Santa Cruz Foundation

California at Santa Cruz, University of

195

Women and Heart Disease: Neglected Directions for Future Research  

E-Print Network (OSTI)

009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

Barrett-Connor, Elizabeth

2009-01-01T23:59:59.000Z

196

Characterization of a Drosophila model of Huntington's disease  

E-Print Network (OSTI)

Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

Lee, Wyan-Ching Mimi

2006-01-01T23:59:59.000Z

197

Fatty Acids in Health Promotion and Disease Causation  

Science Conference Proceedings (OSTI)

The Fatty Acids in Health Promotion and Disease Causation book has four main focuses and sections. Fatty Acids in Health Promotion and Disease Causation Health acid analysis aocs april articles chloropropanediol contaminants detergents dietary fats divis

198

Infectious Disease Modeling of Social Contagion in Networks  

E-Print Network (OSTI)

Many behavioral phenomena have been found to spread interpersonally through social networks, in a manner similar to infectious diseases. An important difference between social contagion and traditional infectious diseases, ...

Hill, Alison Lynn

199

Increase in Diarrheal Disease Associated with Arsenic Mitigation in Bangladesh  

E-Print Network (OSTI)

. Kosek M, Bern C, Guerrant RL (2003) The global burden of diarrhoeal disease, as estimated from studies

van Geen, Alexander

200

Review: A review of advanced techniques for detecting plant diseases  

Science Conference Proceedings (OSTI)

Diseases in plants cause major production and economic losses in agricultural industry worldwide. Monitoring of health and detection of diseases in plants and trees is critical for sustainable agriculture. To the best of our knowledge, there is no sensor ... Keywords: GC-MS, Imaging techniques, Plant diseases, Spectroscopy, Volatile profiling

Sindhuja Sankaran; Ashish Mishra; Reza Ehsani; Cristina Davis

2010-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Cluster analysis of genome-wide expression differences in disease-unaffected ileal mucosa in inflammatory bowel diseases  

Science Conference Proceedings (OSTI)

Whole human genome (Agilent) expression profiling was conducted on disease-unaffected ileal RNA collected from the proximal margin of resected ileum from 47 ileal Crohn's disease (CD), 27 ulcerative colitis (UC) and 25 control patients without inflammatory ...

Tianyi Zhang; Robert A. DeSimone; Hongyan Chen; Christina M. Hamm; Jeffrey Yuan; Qing Qing Gong; Steven R. Hunt; Themistocles Dassopoulos; Rodney D. Newberry; Daniel N. Frank; Charles E. Robertson; Norman R. Pace; Erica Sodergren; George Weinstock; Xiangmin Jiao; Wei Zhu; Ellen Li

2011-02-01T23:59:59.000Z

202

Fatty Acids in Health Promotion and Disease CausationChapter 7 Dietary Fatty Acids in Cardiovascular Disease in Women  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 7 Dietary Fatty Acids in Cardiovascular Disease in Women Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf ...

203

Analysis of Dose Response for Circulatory Disease After Radiotherapy for Benign Disease  

SciTech Connect

Purpose: To assess the shape of the dose-response for various circulatory disease endpoints, and modifiers by age and time since exposure. Methods and Materials: This was an analysis of the US peptic ulcer data testing for heterogeneity of radiogenic risk by circulatory disease endpoint (ischemic heart, cerebrovascular, other circulatory disease). Results: There were significant excess risks for all circulatory disease, with an excess relative risk Gy{sup -1} of 0.082 (95% CI 0.031-0.140), and ischemic heart disease, with an excess relative risk Gy{sup -1} of 0.102 (95% CI 0.039-0.174) (both p = 0.01), and indications of excess risk for stroke. There were no statistically significant (p > 0.2) differences between risks by endpoint, and few indications of curvature in the dose-response. There were significant (p < 0.001) modifications of relative risk by time since exposure, the magnitude of which did not vary between endpoints (p > 0.2). Risk modifications were similar if analysis was restricted to patients receiving radiation, although the relative risks were slightly larger and the risk of stroke failed to be significant. The slopes of the dose-response were generally consistent with those observed in the Japanese atomic bomb survivors and in occupationally and medically exposed groups. Conclusions: There were excess risks for a variety of circulatory diseases in this dataset, with significant modification of risk by time since exposure. The consistency of the dose-response slopes with those observed in radiotherapeutically treated groups at much higher dose, as well as in lower dose-exposed cohorts such as the Japanese atomic bomb survivors and nuclear workers, implies that there may be little sparing effect of fractionation of dose or low-dose-rate exposure.

Little, Mark P., E-mail: mark.little@nih.gov [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States); Kleinerman, Ruth A. [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States)] [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States); Stovall, Marilyn; Smith, Susan A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mabuchi, Kiyohiko [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States)] [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States)

2012-12-01T23:59:59.000Z

204

Snakes  

NLE Websites -- All DOE Office Websites (Extended Search)

Snakes Snakes Nature Bulletin No. 36 October 13, 1945 Forest Preserve District of Cook County Clayton F. Smith, President Roberts Mann, Superintendent of Conservation SNAKES If you were a snake you would never have an earache or get dust in your eye. They have inner ears but no trace of an outside ear or eardrum, A sleeping snake will pay no attention to shouts or banging on a tin pan, but rouses immediately when a man or other animal walks near. Apparently snakes hear by feeling the vibrations of the earth, just as a person can hear a distant train by putting his ear to the track. Snakes are very short-sighted, their eyes being specially constructed for focusing on nearby small objects. That "glassy stare" is produced by a transparent cap or lid which covers the eye and cannot be moved. The eyeball inside is just as movable as yours.

205

Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata  

E-Print Network (OSTI)

predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

Leistikow, Bruce N.

2009-01-01T23:59:59.000Z

206

Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease  

E-Print Network (OSTI)

in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang

Chang, Ruey-Kang R.; Chen, Alex Y.

2010-01-01T23:59:59.000Z

207

Chronic Beryllium Disease Prevention Program Report  

SciTech Connect

This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

Lee, S

2012-03-29T23:59:59.000Z

208

Gallium 67 scintigraphy in glomerular disease  

Science Conference Proceedings (OSTI)

To evaluate the diagnostic usefulness of gallium 67 scintigraphy in glomerular disease, 45 patients with various glomerulopathies, excluding lupus nephritis and renal vasculitis, were studied. Persistent renal visualization 48 hours after the gallium injection, a positive scintigram, was graded as + (less than), ++ (equal to), and +++ (greater than) the hepatic uptake. Positive scintigrams were seen in ten of 16 cases of focal segmental glomerulosclerosis, six of 11 cases of proliferative glomerulonephritis, and one case of minimal change, and one of two cases of membranous nephropathy; also in three of six cases of sickle glomerulopathy, two cases of diabetic neuropathy, one of two cases of amyloidosis, and one case of mild chronic allograft rejection. The 25 patients with positive scans were younger than the 20 with negative scans (31 +/- 12 v 42 +/- 17 years; P less than 0.01), and exhibited greater proteinuria (8.19 +/- 7.96 v 2.9 +/- 2.3 S/d; P less than 0.01) and lower serum creatinine values (2 +/- 2 v 4.1 +/- 2.8 mg/dL; P less than 0.01). The amount of proteinuria correlated directly with the intensity grade of the gallium image (P less than 0.02), but there was no correlation between the biopsy diagnosis and the outcome of the gallium scan. It was concluded that gallium scintigraphy is not useful in the differential diagnosis of the glomerular diseases under discussion. Younger patients with good renal function and heavy proteinuria are likely to have a positive renal scintigram regardless of the underlying glomerulopathy.

Bakir, A.A.; Lopez-Majano, V.; Levy, P.S.; Rhee, H.L.; Dunea, G.

1988-12-01T23:59:59.000Z

209

What Connects Rat Tails to Cancer and Heart Disease?  

NLE Websites -- All DOE Office Websites (Extended Search)

What Connects Rat Tails to Cancer and Heart Disease? Collagen is the main (and most abundant) protein in all mammalian connective tissues, including those of the heart, lungs,...

210

Optimization Methods for Disease Prevention and Epidemic Control  

E-Print Network (OSTI)

Sep 29, 2013 ... Abstract: This paper investigates problems of disease prevention and epidemic control (DPEC), in which we optimize two sets of decisions: (i)...

211

The political economy of health: death, disease and distribution.  

E-Print Network (OSTI)

??Death and disease exact a heavy toll on citizens in democracies. In response, citizens expect elected politicians to alleviate their suffering by providing public health (more)

Meserve, Stephen A.

2011-01-01T23:59:59.000Z

212

Genomics of emerging infectious disease: A PLoS collection.  

E-Print Network (OSTI)

Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

Eisen, Jonathan A; MacCallum, Catriona J

2009-01-01T23:59:59.000Z

213

High-Resolution Serum Proteomic Profiling of Alzheimer Disease Samples Reveals Disease- Specific, Carrier-ProteinBound Mass Signatures  

E-Print Network (OSTI)

Background: Researchers typically search for disease markers using a targeted approach in which a hypothesis about the disease mechanism is tested and experimental results either confirm or disprove the involvement of a particular gene or protein in the disease. Recently, there has been interest in developing disease diagnostics based on unbiased quantification of differences in global patterns of protein and peptide masses, typically in blood from individuals with and without disease. We combined a suite of methods and technologies, including novel sample preparation based on carrier-protein capture and biomarker enrichment, highresolution mass spectrometry, a unique cohort of wellcharacterized persons with and without Alzheimer disease (AD), and powerful bioinformatic analysis, that add statistical and procedural robustness to biomarker discovery from blood. Methods: Carrier-proteinbound peptides were isolated from serum samples by affinity chromatography, and peptide mass spectra were acquired by a matrixassisted laser desorption/ionization (MALDI) orthogo-

Mary F. Lopez; Alvydas Mikulskis; Scott Kuzdzal; David A. Bennett; Jeremiah Kelly; Eva Golenko; Joseph Dicesare; Eric Denoyer; Wayne F. Patton; Richard Ediger; Tillmann Ziegert; Christopher Lynch; Susan Kramer; Gordon R. Whiteley; Michael R. Wall; David P. Mannion; John S. Rakitan; Gershon M. Wolfe

2005-01-01T23:59:59.000Z

214

A hybrid tele-diagnosis system on fish disease  

Science Conference Proceedings (OSTI)

Fish disease diagnosis is a complicated process and requires high level of expertise, an expert system for fish disease diagnosis is considered as an effective tool to help fish farmers. However, many farmers have no computers and are not able to access ... Keywords: call centre, expert system, group decision support system, machine learning

Daoliang Li; Wei Zhu; Zetian Fu

2006-04-01T23:59:59.000Z

215

Computational intelligence techniques: a study of scleroderma skin disease  

Science Conference Proceedings (OSTI)

This paper presents an analysis of microarray gene expression data from patients with and without scleroderma skin disease using computational intelligence and visual data mining techniques. Virtual reality spaces are used for providing unsupervised ... Keywords: Scleroderma disease, clustering, differential evolution, genetic programming, genomics, grid computing, hybrid evolutionary-classical optimization, particle swarm optimization, rough sets, similarity structure preservation, virtual reality spaces, visual data mining

Julio J. Valdes; Alan J. Barton

2007-07-01T23:59:59.000Z

216

DISEASE SUPPRESSION WITH COMPOST: HISTORY, PRINCIPLES AND FUTURE  

E-Print Network (OSTI)

Composts have been used for centuries to maintain soil fertility and plant health. Even so, the mechanisms by which diseases are controlled by composts are just now being elucidated. This paper reviews the recent history on control of plant diseases with composts. Furthermore, the present state of knowledge in this field is reviewed. Finally, potential future opportunities for

Harry A. J. Hoitink; Professor Emeritus; Ligia Zuniga De Ramos; Senior Fullbright

2004-01-01T23:59:59.000Z

217

Computer aided diagnosis of Alzheimer's disease using component based SVM  

Science Conference Proceedings (OSTI)

Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder first affecting memory functions and then gradually affecting all cognitive functions with behavioural impairments and eventually causing death. Functional brain imaging as ... Keywords: Alzheimer's disease, Computer aided diagnosis, Single photon emission computed tomography, Support vector machines

I. A. Illn; J. M. Grriz; M. M. Lpez; J. Ramrez; D. Salas-Gonzalez; F. Segovia; R. Chaves; C. G. Puntonet

2011-03-01T23:59:59.000Z

218

Proteins' Amazing Origami Powers: Insight for Potential Disease Treatments  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Proteins' Amazing Origami Powers: Insight for Potential Disease Proteins' Amazing Origami Powers: Insight for Potential Disease Treatments Proteins' Amazing Origami Powers: Insight for Potential Disease Treatments October 4, 2011 - 12:46pm Addthis This is a visualization of drug molecules ("parade day-like balloons") in a simulated attack of the ribbon-like protein fibrils that are believed to be the cause of Alzheimer’s disease. Click here to see more amazing supercomputer simulations. | Image courtesy of ORNL. This is a visualization of drug molecules ("parade day-like balloons") in a simulated attack of the ribbon-like protein fibrils that are believed to be the cause of Alzheimer's disease. Click here to see more amazing

219

Status Report, Department of Energy's Chronic Beryllium Disease Prevention  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Status Report, Department of Energy's Chronic Beryllium Disease Status Report, Department of Energy's Chronic Beryllium Disease Prevention Program - February 2006 Status Report, Department of Energy's Chronic Beryllium Disease Prevention Program - February 2006 February 2006 Report on Implementation of 10 CFR Part 850, Chronic Beryllium Disease Prevention Program During calendar year 2005, the Office of Independent Oversight, within the Office of Security and Safety Performance Assurance, evaluated the effectiveness of U.S. Department of Energy (DOE) chronic beryllium disease protection programs (CBDPPs) at five sites as part of regularly scheduled inspections. These reviews focused on site programs for ensuring that workers are protected in accordance with the requirements of 10 CFR 850. This report summarizes the observations, insights, and lessons learned from

220

Status Report, Department of Energy's Chronic Beryllium Disease Prevention  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Status Report, Department of Energy's Chronic Beryllium Disease Status Report, Department of Energy's Chronic Beryllium Disease Prevention Program - February 2006 Status Report, Department of Energy's Chronic Beryllium Disease Prevention Program - February 2006 February 2006 Report on Implementation of 10 CFR Part 850, Chronic Beryllium Disease Prevention Program During calendar year 2005, the Office of Independent Oversight, within the Office of Security and Safety Performance Assurance, evaluated the effectiveness of U.S. Department of Energy (DOE) chronic beryllium disease protection programs (CBDPPs) at five sites as part of regularly scheduled inspections. These reviews focused on site programs for ensuring that workers are protected in accordance with the requirements of 10 CFR 850. This report summarizes the observations, insights, and lessons learned from

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?  

E-Print Network (OSTI)

case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

2011-01-01T23:59:59.000Z

222

Counting small RNA in disease-causing organisms  

NLE Websites -- All DOE Office Websites (Extended Search)

Counting small RNA in disease-causing organisms Counting small RNA in disease-causing organisms Counting small RNA in disease-causing organisms Los Alamos researchers demonstrated improved technical methods capable of directly counting small RNA molecules in pathogenic (disease-causing) bacteria. June 17, 2013 Artist's concept of the fluorescence labeling and detection of small RNA in pathogenic bacteria. Artist's concept of the fluorescence labeling and detection of small RNA in pathogenic bacteria. The new technique reduced the number of false positives, which improved the accuracy of the count statistics, and it significantly reduced the image processing time. Small molecules of RNA (tens to hundreds of nucleotides in length) play a key regulatory role in bacteria. Due to their small size, directly

223

Medicating race : heart disease and durable preoccupations with difference  

E-Print Network (OSTI)

This dissertation is an examination of intersections of race, pharmaceuticals, and heart disease over the course of the 20th century and today. Each of these parts has had a dynamic history, and when they are invoked ...

Pollock, Anne, Ph. D. Massachusetts Institute of Technology

2007-01-01T23:59:59.000Z

224

Indoor CO2 and Communicable Disease Transmission in Offices and...  

NLE Websites -- All DOE Office Websites (Extended Search)

Indoor CO2 and Communicable Disease Transmission in Offices and Non-Industrial Environments Speaker(s): Don Milton Date: October 16, 2000 - 12:00pm Location: Bldg. 90 Seminar Host...

225

Threshold Relative Humidity Duration Forecasts for Plant Disease Prediction  

Science Conference Proceedings (OSTI)

Duration of high relative humidity periods is an important component of many plant disease development models. Performance of forecasts of this quantity, based on the model output statistics 3-h temperature and dewpoint forecasts produced by the ...

Daniel S. Wilks; Karin W. Shen

1991-04-01T23:59:59.000Z

226

Simulating Lyme disease using parallel discrete event simulation  

Science Conference Proceedings (OSTI)

Lyme Disease affects many people in the northeastern United States. One of the most important mech anisms that sustains the epidemic is the interaction between white-footed mice (Peromyscus leuco pus) and deer ticks (Ixodes scapularis). When mice move ...

Ewa Deelman; Boleslaw K. Szymanski; Thomas Caraco

1996-11-01T23:59:59.000Z

227

Accelerating Spatially Explicit Simulations of Spread of Lyme Disease  

Science Conference Proceedings (OSTI)

The factors influencing spread of Lyme disease are often studied using computer-based simulations and spatially explicit models. However, simulating large and complex models is a time consuming task, even when parallel simulation techniques are employed. ...

Dhananjai M. Rao; Philip A. Wilsey

2005-04-01T23:59:59.000Z

228

6 DISEASE-PRONE CROWS Study of inbred crows has  

E-Print Network (OSTI)

the determinants of transmission of diseases to humans, non- human animals, or plants; the spread of pathogens processing methods such as molding, forging, casting, welding, hydroforming, composite layup, and other

Keinan, Alon

229

Cerebrospinal Fluid Proteome of Patients with Acute Lyme Disease  

Science Conference Proceedings (OSTI)

Acute Lyme disease results from transmission of and infection by the bacterium Borrelia burgdorferi following a tick bite. During acute infection, bacteria can disseminate to the central nervous system (CNS) leading to the development of Lyme meningitis. Here we have analyzed pooled cerebrospinal fluid (CSF) allowing for a deep view into the proteome for a cohort of patients with early-disseminated Lyme disease and CSF inflammation leading to the identification of proteins that reflect host responses, which are distinct for subjects with acute Lyme disease. Additionally, we analyzed individual patient samples and quantified changes in protein abundance employing label-free quantitative mass spectrometry based methods. The measured changes in protein abundances reflect the impact of acute Lyme disease on the CNS as presented in CSF. We have identified 89 proteins that differ significantly in abundance in patients with acute Lyme disease. A number of the differentially abundant proteins have been found to be localized to brain synapse and thus constitute important leads for better understanding of the neurological consequence of disseminated Lyme disease.

Angel, Thomas E.; Jacobs, Jon M.; Smith, Robert P.; Pasternack, Mark S.; Elias, Susan; Gritsenko, Marina A.; Shukla, Anil K.; Gilmore, Edward C.; McCarthy, Carol; Camp, David G.; Smith, Richard D.

2012-10-05T23:59:59.000Z

230

TARGET SPECIES Table 1. Terrestrial target species.  

E-Print Network (OSTI)

Grebe Red-breasted Merganser N. Rough-winged Swallow Red-necked Grebe Ruddy Duck Bank Swallow Eared Brown Creeper Red-eyed Vireo Golden-mantled Grnd Squirrel CFLS Brown-headed Cowbird CFLS Red CFLS Williamson's Sapsucker CFLS Red Squirrel CFLS Gyrfalcon FS Willow Flycatcher River Otter Hammond

231

Rheumatic Heart Disease and Beta-hemolytic Streptococci in Salvador, Brazil: A Study of Slum Health  

E-Print Network (OSTI)

rheumatic fever and rheumatic heart disease in Africa. S Afrthe chain that links the heart to the throat? Lancet Infectchildren with rheumatic heart disease. J Thorac Cardiovasc

Tartof, Sara Yee

2010-01-01T23:59:59.000Z

232

Airborne spread of foot-and-mouth disease - model intercomparison  

SciTech Connect

Foot-and-mouth disease is a highly infectious vesicular disease of cloven-hoofed animals caused by foot-and-mouth disease virus. It spreads by direct contact between animals, by animal products (milk, meat and semen), by mechanical transfer on people or fomites and by the airborne route - with the relative importance of each mechanism depending on the particular outbreak characteristics. Over the years a number of workers have developed or adapted atmospheric dispersion models to assess the risk of foot-and-mouth disease virus spread through the air. Six of these models were compared at a workshop hosted by the Institute for Animal Health/Met Office during 2008. A number of key issues emerged from the workshop and subsequent modelling work: (1) in general all of the models predicted similar directions for 'at risk' livestock with much of the remaining differences strongly related to differences in the meteorological data used; (2) determination of an accurate sequence of events is highly important, especially if the meteorological conditions vary substantially during the virus emission period; and (3) differences in assumptions made about virus release, environmental fate, and subsequent infection can substantially modify the size and location of the downwind risk area. Close relationships have now been established between participants, which in the event of an outbreak of disease could be readily activated to supply advice or modelling support.

Gloster, J; Jones, A; Redington, A; Burgin, L; Sorensen, J H; Turner, R; Dillon, M; Hullinger, P; Simpson, M; Astrup, P; Garner, G; Stewart, P; D'Amours, R; Sellers, R; Paton, D

2008-09-04T23:59:59.000Z

233

77. Mudugar video documentaries, In their eyes...  

E-Print Network (OSTI)

literature of an indigenous community called Mudugar. Mudugar live in the mountainous land of Attapady, Palakkad District, Kerala State, South India. The photographs, video-documentaries, audio files and translated interviews are materials collected over a...

Alex, Rayson K.

234

Dynamical Systems in Circuit Designer's Eyes  

SciTech Connect

Examples of nonlinear circuit design are given. Focus of the design process is on theory and engineering methods (as opposed to numerical analysis). Modeling is related to measurements It is seen that the phase plane is still very useful with proper models Harmonic balance/describing function offers powerful insight (via the combination of simulation with circuit and ODE theory). Measurement and simulation capabilities increased, especially harmonics measurements (since sinusoids are easy to generate)

Odyniec, M.

2011-05-09T23:59:59.000Z

235

A LOOK INSIDE THE LIVING EYE  

This work performed under the auspices of the U.S. Department of Energy by Lawrence ... in vivo visualization and characterization of all ... light coming into the ...

236

Big storage facilities eyed in Texas, Louisiana  

SciTech Connect

Two large oil natural gas storage facilities are planned in U.S. Gulf Coast states. This paper reports that two Houston companies propose to construct a storage facility in Louisiana with more than 50 bcf of working gas capacity. And units of ARCO and Plains Resources have signed a letter of intent expected to lead to construction of a 600,000 bbl crude oil storage facility on the Houston ship channel.

Not Available

1992-03-09T23:59:59.000Z

237

Chrysler eyes waste-fired powerhouse  

SciTech Connect

The Chrysler Corporation is exploring the feasibility of building a solid-waste-fired powerhouse rather than spend up to $60 million converting two existing powerhouses to burn coal and still meet the Environmental Protection Agency's high emission standards for the Detroit area. Neither construction nor conversion could be completed in time to avoid a new gas tax. Chrysler is converting powerhouses in areas outside Detroit. The powerhouse under consideration will produce steam from all Chrysler-produced solid waste to supply eight plants and allow the two current powerhouses to be shut down. Chrysler is also converting boilers back to coal and hopes to attain the 99 percent emission cut required without too great an expenditure. Some coal-handling equipment was retained after an earlier conversion to gas. Chrysler presently uses more natural gas than its competitors (59 percent compared to 38 percent) because of its policy of using clean, cheap, and efficient fuels. An energy-saving change underway at Chrysler is the replacement of precision-forming parts for hot-forging. Chrysler's policy of only approving capital expenditures that have two-year paybacks is hampering some conservation projects. (DCK)

Frey, C.

1977-05-30T23:59:59.000Z

238

The Solar Corona Through Numerical Eyes.  

E-Print Network (OSTI)

??The Sun and the Space environment serve as a natural laboratory to study the physics of ionized gas (plasma) under extreme conditions, which are nearly (more)

Cohen, Ofer

2008-01-01T23:59:59.000Z

239

NIST'S NEW 'ELECTRONIC EYE' IMPROVES ACCURACY ...  

Science Conference Proceedings (OSTI)

... from a light source to a light detector as a ... manufacturers can still purchase standard bulbs from NIST ... to calibrate detectors for the lighting industry. ...

240

`Electronic Eye' Improves Accuracy in Lighting  

Science Conference Proceedings (OSTI)

... candela standard will help the lighting industry meet ... a light source to a light detector as a ... manufacturers can still purchase standard bulbs from NIST ...

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Keeping an eye on power system dynamics  

SciTech Connect

An interconnected power system is one of the largest and most complex of human achievements. It is maintained in a stable dynamic state only by tight control and protection, plus intelligent and diligent operation. Operating details are taken for granted by the general public; only when some catastrophic failure takes place is power system stability seen as newsworthy. Faults occur on power systems, most often through natural phenomena beyond human control. However, a well designed system will, for the most common faults, recover automatically and continue power delivery with very little inconvenience to its customers. This level of performance is achieved at a high cost in terms of manpower and equipment. In the future, the market economy is likely to force power systems much closer to their limits of stable operation, and operating decisions will have to be based on accurate, online system information and simulations rather than the current practice of extensive offline simulation of a comprehensive set of possible system operating conditions.

Hauer, J.; Johnson, J. [Pacific Northwest National Lab., Richland, WA (United States); Mittelstadt, B.; Litzenberger, W. [Bonneville Power Administration, Portland, OR (United States); Trudnowski, D.; Rogers, G.

1997-10-01T23:59:59.000Z

242

Eye-Opening Possibilities in Imaging  

Office of Science (SC) Website

tool developed by Berkeley Lab, may show the way to everything from better biofuels to more effective medicines. Print Text Size: A A A Subscribe FeedbackShare Page...

243

The invented eye looks at architecture  

E-Print Network (OSTI)

Architecture and photography are two aspects of our shared visual culture. The influence exerted by photography on architecture is in a large part due to the power insisting upon "actuality" of what has to be seen in the ...

Hazra, Ashish

1988-01-01T23:59:59.000Z

244

Eye movements in reading as rational behavior  

E-Print Network (OSTI)

Reading as Bayesian inference . . . . . . . . . . . 3.4.1Object perception as Bayesian inference. Annual Review ofknowledge through Bayesian inference to yield posterior

Bicknell, Klinton

2011-01-01T23:59:59.000Z

245

Public places through the private eye  

E-Print Network (OSTI)

The radical change in the pattern of everyday communication has corresponded with a rapid transformation of the character of public urban places and the way they are used. The urban network is no longer the primary space ...

Gspr, Zsuzsanna, 1967-

1993-01-01T23:59:59.000Z

246

A bird's eye view of quantum computers  

E-Print Network (OSTI)

Quantum computers are discussed in the general framework of computation, the laws of physics and the foundations of quantum mechanics.

Giuliano Benenti; Giuliano Strini

2007-03-13T23:59:59.000Z

247

Title 10 CFR Part 850, Chronic Beryllium Disease Prevention Program  

NLE Websites -- All DOE Office Websites (Extended Search)

Wednesday Wednesday December 8, 1999 Part III Department of Energy 10 CFR Part 850 Chronic Beryllium Disease Prevention Program; Final Rule VerDate 29-OCT-99 10:58 Dec 07, 1999 Jkt 190000 PO 00000 Frm 00001 Fmt 4717 Sfmt 4717 E:\FR\FM\A08DE0.189 pfrm04 PsN: 08DER3 68854 Federal Register / Vol. 64, No. 235 / Wednesday, December 8, 1999 / Rules and Regulations DEPARTMENT OF ENERGY 10 CFR Part 850 [Docket No. EH-RM-98-BRYLM] RIN 1901-AA75 Chronic Beryllium Disease Prevention Program AGENCY: Office of Environment, Safety and Health, Department of Energy. ACTION: Final rule. SUMMARY: The Department of Energy (DOE) is today publishing a final rule to establish a chronic beryllium disease prevention program (CBDPP) to reduce the number of workers currently exposed to beryllium in the course of their work at DOE facilities managed by

248

Bush Administration to Expand Beryllium Disease Screening Program |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Bush Administration to Expand Beryllium Disease Screening Program Bush Administration to Expand Beryllium Disease Screening Program Bush Administration to Expand Beryllium Disease Screening Program February 23, 2005 - 10:27am Addthis Former employees of DOE vendors eligible for free screening WASHINGTON, DC - U.S. Secretary of Energy Samuel W. Bodman today announced the Department of Energy (DOE) will expand a beryllium screening program to include former employees of now-defunct DOE beryllium vendor companies across the country. Beryllium is a component used in nuclear weapons built by the Department of Energy. "Through no fault of their own, these Cold Warriors were left out in the cold when their former employers went out of business. By expanding this screening program, President Bush and the Department of Energy honor these

249

Investigation of saliva of patients with periodontal disease using NAA  

SciTech Connect

In this study the non-stimulated whole saliva of 26 healthy subjects (mean age 33.9 {+-} 11.0 years, range: 26 to 49 years) and 11 patients with periodontal disease (mean age 41.7 {+-} 11.5 years; range 29 to 55 years) was investigated using Neutron Activation Analysis (NAA) technique. The samples were obtained from donors at Sao Paulo city (Brazil). The analyses were performed in the nuclear reactor IEA-R1 (3.5-4.5MW, pool type) at IPEN/CNEN-SP (Brazil). Considerable changes in Ca and S saliva's level were identified in patients with periodontal disease suggesting they can be used as monitors of periodontal diseases.

Zamboni, C. B.; Metairon, S.; Medeiros, I. M. M. A. [Instituto de Pesquisas Energeticas e Nucleares, IPEN - CNEN/SP Av. Professor Lineu Prestes 2242- 05508-000 Sao Paulo, SP (Brazil); Lewgoy, H. R. [Universidade Anhanguera Bandeirante, UNIBAN R. Maria Candida, 1813, Bloco G / 6o andar - 02071-013 Sao Paulo, SP (Brazil)

2013-05-06T23:59:59.000Z

250

LLNL Chronic Beryllium Disease Protection Program Effectiveness Review, March 2011  

NLE Websites -- All DOE Office Websites (Extended Search)

LLNL-2011-03-25 LLNL-2011-03-25 Site: Lawrence Livermore National Laboratory Subject: Office of Enforcement and Oversight's Office of Safety and Emergency Management Evaluations Activity Report for the Lawrence Livermore National Laboratory Chronic Beryllium Disease Prevention Program Effectiveness Review Dates of Activity : 03/14/2011 - 03/25/2011 Report Preparer: Marvin Mielke Activity Description/Purpose: The Lawrence Livermore National Laboratory (LLNL) and the Livermore Site Office (LSO) chartered a team to conduct an effectiveness review of the issues identified with the LLNL Chronic Beryllium Disease Prevention Program (CBDPP). The team included members and observers from LLNL, LSO, the National Nuclear Security Administration (NNSA), and the

251

LLNL Chronic Beryllium Disease Protection Program Effectiveness Review, March 2011  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

LLNL-2011-03-25 LLNL-2011-03-25 Site: Lawrence Livermore National Laboratory Subject: Office of Enforcement and Oversight's Office of Safety and Emergency Management Evaluations Activity Report for the Lawrence Livermore National Laboratory Chronic Beryllium Disease Prevention Program Effectiveness Review Dates of Activity : 03/14/2011 - 03/25/2011 Report Preparer: Marvin Mielke Activity Description/Purpose: The Lawrence Livermore National Laboratory (LLNL) and the Livermore Site Office (LSO) chartered a team to conduct an effectiveness review of the issues identified with the LLNL Chronic Beryllium Disease Prevention Program (CBDPP). The team included members and observers from LLNL, LSO, the National Nuclear Security Administration (NNSA), and the

252

Dietary Fats and Risk of Chronic DiseaseChapter 15 Perinatal Supplementation of Long-chain Polyunsaturated Fatty Acids as a Strategy to Prevent Adult Diseases  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 15 Perinatal Supplementation of Long-chain Polyunsaturated Fatty Acids as a Strategy to Prevent Adult Diseases Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Pr

253

Fatty Acids in Health Promotion and Disease CausationChapter 5 Fatty Acids in Corn Oil: Role in Heart Disease Prevention  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 5 Fatty Acids in Corn Oil: Role in Heart Disease Prevention Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf ...

254

Fatty Acids in Health Promotion and Disease CausationChapter 22 Fatty Acids in Immunomodulation: Role in Disease Prevention and Causation  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 22 Fatty Acids in Immunomodulation: Role in Disease Prevention and Causation Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press D

255

Fatty Acids in Health Promotion and Disease CausationChapter 2 Nutrition and Cardiovascular Disease in American Indians and Alaska Natives  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 2 Nutrition and Cardiovascular Disease in American Indians and Alaska Natives Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press

256

Fatty Acids in Health Promotion and Disease CausationChapter 8 Free Fatty Acids: Role in Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 8 Free Fatty Acids: Role in Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press

257

Fatty Acids in Health Promotion and Disease CausationChapter 18 Fatty Acids in Membrane Lipids: Role in Disease Causation and Prevention  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 18 Fatty Acids in Membrane Lipids: Role in Disease Causation and Prevention Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Do

258

Fatty Acids in Health Promotion and Disease CausationChapter 13 Trans and Other Fatty Acids: Role in Diabetic Disease and Health  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 13 Trans and Other Fatty Acids: Role in Diabetic Disease and Health Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadab

259

Fatty Acids in Health Promotion and Disease CausationChapter 9 Gender Differences in Gene Expression Due to Fatty Acids: Role in Atherosclerosis and Cardiovascular Disease  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 9 Gender Differences in Gene Expression Due to Fatty Acids: Role in Atherosclerosis and Cardiovascular Disease Health Nutrition Biochemistry eChapters Health - Nutrition - Bio

260

Detecting disease genes based on semi-supervised learning and protein-protein interaction networks  

Science Conference Proceedings (OSTI)

Objective: Predicting or prioritizing the human genes that cause disease, or ''disease genes'', is one of the emerging tasks in biomedicine informatics. Research on network-based approach to this problem is carried out upon the key assumption of ''the ... Keywords: Disease gene neighbours, Disease-causing gene prediction, Multiple data resources integration, Protein-protein interaction network, Semi-supervised learning

Thanh-Phuong Nguyen; Tu-Bao Ho

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Development of a smart e-health portal for chronic disease management  

Science Conference Proceedings (OSTI)

In developed countries, chronic disease now accounts for more than 75% of health care expenditure and nearly an equivalent percentage of disease related deaths. In response to these changes in disease demographics and the economic imperatives caused ... Keywords: chronic disease, decision support, e-health portal

Maryam Haddad; Girija Chetty

2012-09-01T23:59:59.000Z

262

Comparing disease expression across species: an examination of radiation and species specific disease expression in Mus musculus and Peromyscus leucopus  

NLE Websites -- All DOE Office Websites (Extended Search)

disease expression across species: an examination of radiation and species specific disease expression across species: an examination of radiation and species specific disease expression in Mus musculus and Peromyscus leucopus William Liu 1 , Benjamin Haley 1 , Mary J. Kwasny 2 , Tatjana Paunesku 1 , Gayle Woloschak 1 1. Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2. Department of Preventative Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 From 1969 to 1992, the Janus program at Argonne National Laboratory performed a large series of radiobiology experiments, examining the effects of varying doses of neutron and gamma radiation on two disparate species of mice, Mus musculus and Peromyscus leucopus. Much of this data has since been digitized and made freely accessible online. This study aims to revisit

263

Managing Complexity: Disease Control as a Complex Adaptive System  

Science Conference Proceedings (OSTI)

Trends in computer and communications technologies are enabling increased globalization and integration of enterprises, and corresponding increases of enterprise complexity.ᅠᅠThis article addresses management of this complexity using a complex adaptive ... Keywords: complex adaptive systems, disease control, strategic management, complexity, system models

William B. Rouse

2000-04-01T23:59:59.000Z

264

Virus Specificity in Disease Systems: Are Species Redundant?  

E-Print Network (OSTI)

studies have stressed the prevalence of viruses in natural plant populations (e.g., Power and Remold 1996 the growth, survivorship, and reproduction of nondomesticated plants (Friess and Maillet 1996, 1997; FunayamaChapter 17 m Virus Specificity in Disease Systems: Are Species Redundant? Alison G. Power

Flecker, Alex

265

452 Plant Disease / Vol. 82 No. 5 A. R. Biggs  

E-Print Network (OSTI)

452 Plant Disease / Vol. 82 No. 5 A. R. Biggs West Virginia University, Kearneysville G. G. Grove with information sharing in plant pathology extension via the World Wide Web; (ii) provide background on hardware of current and future web-based technologies that potentially influence extension plant pathology. West

Biggs, Alan R.

266

Ensemble transcript interaction networks: A case study on Alzheimer's disease  

Science Conference Proceedings (OSTI)

Systems biology techniques are a topic of recent interest within the neurological field. Computational intelligence (CI) addresses this holistic perspective by means of consensus or ensemble techniques ultimately capable of uncovering new and relevant ... Keywords: Alzheimer's disease, Bayesian network classifiers, High-throughput data, Interaction networks

RubN ArmaAnzas; Pedro LarraAga; Concha Bielza

2012-10-01T23:59:59.000Z

267

A 3-D Link between Antibiotic Resistance and Brain Disease  

NLE Websites -- All DOE Office Websites (Extended Search)

A 3-D Link between Antibiotic Resistance and Brain Disease A 3-D Link between Antibiotic Resistance and Brain Disease The story of what makes certain types of bacteria resistant to a specific antibiotic has a sub-plot that gives insight into the cause of a rare form of brain degeneration among children, according to investigators at St. Jude Children's Research Hospital. The story takes a twist as key differences among the structures of its main molecular characters disappear and reappear as they are assembled in the cell. The story is based on a study of the three-dimensional (3-D) structure of an enzyme called pantothenate kinase, which triggers the first step in the production coenzyme A (CoA), a molecule that is indispensable to all forms of life. Enzymes are proteins that speed up biochemical reactions. CoA plays a pivotal role in the cells' ability to extract energy from fatty

268

LANL spinoff receives NIH grant for respiratory disease diagnostic device  

NLE Websites -- All DOE Office Websites (Extended Search)

LANL spinoff receives NIH grant LANL spinoff receives NIH grant LANL spinoff receives NIH grant for respiratory disease diagnostic device Mesa Tech has been awarded a grant to develop an inexpensive, instrument-free, nucleic-acid testing device to diagnose various respiratory diseases in record time. October 19, 2011 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy

269

Women and Heart Disease: Neglected Directions for Future Research  

E-Print Network (OSTI)

Abstract Before age 65, women have less heart disease than men. For many years, estrogen was the most popular explanation for this female advantage, and observational studies through the 1980s showed a lower risk of heart attacks in postmenopausal women taking replacement estrogen. But the Womens Health Initiative (WHI), the first placebo-controlled trials of hormone therapy with the size and statistical power necessary to study clinical cardiovascular outcomes, did not confirm the hormone-healthy heart hypothesis. Now, at least 5 years later, the most unexpected WHI result may be how resilient the estrogen hypothesis has been. Where, beyond estrogen therapy, should we go from here to explain the striking sex differences in heart disease rates? A broader spectrum of research about the female cardiovascular advantage and its translation is needed.

Elizabeth Barrett-connor

2009-01-01T23:59:59.000Z

270

Perspectives Editorial Guest Editorial Emerging Diseases Threaten Conservation  

E-Print Network (OSTI)

suddenly, sending shockwaves throughout public health systems and economies worldwide. By July 2003, 8,439 cases had been reported worldwide, with 812 deaths; the economic impacts were estimated to be $50$100 billion (U.S.) (Newcomb 2003). Although public attention was focused on this explosive pandemic, more than 30 such diseases new to medicine have emerged since 1976 [World Health Organization (WHO) 1996]. Historically, waves of infections have often accompanied periods of social and environmental transition (Epstein 1992). Such upsurges include influenza in the aftermath of World War I and the plague during the Middle Ages. Tuberculosis, smallpox, and cholera appeared in concert among the teeming urban centers of Charles Dickenss 19thcentury England. In the past three decades, previously unknown diseases have surfaced at a pace without precedent in the annals of medicine. Indeed, such a

unknown authors

2003-01-01T23:59:59.000Z

271

ALS: a disease of motor neurons and their nonneuronal neighbors  

E-Print Network (OSTI)

Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease affecting motor neurons. The etiology of most ALS cases remains unknown, but 2 % of instances are due to mutations in Cu/Zn superoxide dismutase (SOD1). Since sporadic and familial ALS affects the same neurons with similar pathology, it is hoped that therapies effective in mutant SOD1 models will translate to sporadic ALS. Mutant SOD1 induces non-cell-autonomous motor neuron killing by an unknown gain of toxicity. Selective vulnerability of motor neurons likely arises from a combination of several mechanisms, including protein misfolding, mitochondrial dysfunction, oxidative damage, defective axonal transport, excitotoxicity, insufficient growth factor signaling, and inflammation. Damage within motor neurons is enhanced by damage incurred by nonneuronal neighboring cells, via an inflammatory response that accelerates disease progression. These findings validate therapeutic approaches aimed at nonneuronal cells.

Sverine Boille; Christine V; E Velde; Don W. Clevel

2006-01-01T23:59:59.000Z

272

Commentary Meningococcal disease: identifying high-risk cases  

E-Print Network (OSTI)

In the previous issue of Critical Care, Vermont and colleagues presented a simple but well-executed observational study describing the levels of chemokines in the serum of 58 children with meningococcal sepsis. The chemokine levels correlated with disease severity and outcome. Significant correlations were demonstrated between admission chemokine levels and the Paediatric Risk of Mortality score, the Disseminated Intravascular Coagulopathy score, the Sequential Organ Failure Assessment score and laboratory parameters of disease severity. Additionally, nonsurvivors had much higher levels of chemokines compared with survivors, and the chemokine levels predicted mortality with a high degree of sensitivity and specificity. The findings are important as they indicate a possible mechanism for risk stratification in future trials of novel therapies in human sepsis, which as yet have not

David Inwald; Mark Peters

2006-01-01T23:59:59.000Z

273

Analysis of Heart Diseases Dataset using Neural Network Approach  

E-Print Network (OSTI)

One of the important techniques of Data mining is Classification. Many real world problems in various fields such as business, science, industry and medicine can be solved by using classification approach. Neural Networks have emerged as an important tool for classification. The advantages of Neural Networks helps for efficient classification of given data. In this study a Heart diseases dataset is analyzed using Neural Network approach. To increase the efficiency of the classification process parallel approach is also adopted in the training phase.

Rani, K Usha

2011-01-01T23:59:59.000Z

274

Travel and migration associated infectious diseases morbidity in Europe, 2008  

E-Print Network (OSTI)

Infect 2009, 11:1177-1185. 19. NaTHNaC Clinical Update: Tropical Cyclone Nargis in Myanmar - advice for relief workers and other travellers to affected areas. 2008 [http:// www.nathnac.org/pro/clinical_updates/cyclonemyanmar_070508.htm], (Accessed January... ://www.eurotravnet.eu, a network of clinical specialists in tropical and travel medicine was founded in 2008, to assist the European Centre for Dis- ease Prevention & Control (ECDC) for the detection, verification, assessment and communication of commu- nicable diseases...

Field, Vanessa; Gautret, Philippe; Schlagenhauf, Patricia; Burchard, Gerd-Dieter; Caumes, Eric; Jensenius, Mogens; Castelli, Francesco; Gkrania-Klotsas, Effrossyni; Weld, Leisa; Lopez-Velez, Rogelio; de Vries, Peter; von Sonnenburg, Frank; Loutan, Louis; Parola, Philippe; Network, the EuroTravNet

2010-11-17T23:59:59.000Z

275

Towards landscape design guidelines for reducing Lyme disease risk  

E-Print Network (OSTI)

Background Incidence of Lyme disease in the US continues to grow. Low-density development is also increasing in endemic regions, raising questions about the relationship between development pattern and disease. This study sought to model Lyme disease incidence rate using quantitative, practical metrics of regional landscape pattern. The objective was to progress towards the development of design guidelines that may help minimize known threats to human and environmental health. Methods Ecological analysis was used to accommodate the integral landscape variables under study. Case data derived from passive surveillance reports across 12 counties in the US state of Maryland during 19962000; 2137 cases were spatially referenced to residential addresses. Major roads were used to delineate 514 landscape analysis units from 0.002 to 580 km 2. Results The parameter that explained the most variation in incidence rate was the percentage of land-cover edge represented by the adjacency of forest and herbaceous cover [R 2 5 0.75; rate ratio 5 1.34 (1.261.43); P, 0.0001]. Also highly significant was the percentage of the landscape in forest cover (cumulative R 2 5 0.82), which exhibited a quadratic relationship with incidence rate. Modelled relationships applied throughout the range of landscape sizes. Conclusions Results begin to provide quantitative landscape design parameters for reducing casual peridomestic contact with tick and host habitat. The final model suggests that clustered forest and herbaceous cover, as opposed to high forest-herbaceous interspersion, would minimize Lyme disease risk in low-density residential areas. Higher-density development that precludes a large percentage of forestherbaceous edge would also limit exposure.

Laura E Jackson; Elizabeth D Hilborn; James C Thomas

2005-01-01T23:59:59.000Z

276

Lyme Disease in New Jersey, 1978-1982  

E-Print Network (OSTI)

occurred in a four-township area in central Monmouth County. The proportion of cases with arthritis decreased in 1982 because of early antibiotic treatment and better reporting of milder cases. The proportion of cases with positive serology increased with severity of the clinical syndrome. About 25 percent of patients had exposure to ticks because of occupations that required outdoor activities. Lyme disease is a growing public health problem in New Jersey.

G. Stephen Bowen; Terry L. Schulze, Ph.D.; William; L. Parkin; Dr. P. H

1983-01-01T23:59:59.000Z

277

Lorentz-force actuated needle-free injection for intratympanic pharmaceutical delivery  

E-Print Network (OSTI)

Delivery of pharmaceuticals to the inner ear via injection through the tympanic membrane is a method of local drug delivery that provides a non-invasive, outpatient procedure to treat many of the disorders and diseases ...

Cloutier, Alison (Alison Marie)

2013-01-01T23:59:59.000Z

278

Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla  

E-Print Network (OSTI)

Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla and Alzheimer's disease based on high resolution MRI at 3 Tesla. T1-weighted images were acquired from 19

Thompson, Paul

279

A common allele on chromosome 9 associated with coronary heart disease  

E-Print Network (OSTI)

M. Appleyard, European Heart Journal 3, Suppl H. , H1 (associated with Coronary Heart Disease in whites. Minor9 associated with coronary heart disease Ruth McPherson 1* ,

2007-01-01T23:59:59.000Z

280

The power of linkage analysis of a disease-related endophenotype using asymmetrically ascertained sib pairs  

Science Conference Proceedings (OSTI)

A linkage study of a qualitative disease endophenotype in a sample of sib pairs, consisting of one disease affected proband and one sibling is considered. The linkage statistic compares marker allele sharing with the proband in siblings with an abnormal ...

Heejong Sung; Fei Ji; Deborah L. Levy; Steven Matthysse; Nancy Role Mendell

2009-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Centers for Disease Control and Prevention National Center for Environmental Health  

E-Print Network (OSTI)

the Hanford Thyroid Disease Study Final Report June 21, 2002 #12;Communications Plan for releasing the Hanford Thyroid Disease Study Final Report Table of Contents Introduction ........................................................................................................ 15 Hanford Area Public

282

ORIGINAL PAPER Invading with biological weapons: the role of shared disease in ecological invasion  

E-Print Network (OSTI)

Abstract Theory has been developed that examines the role of infectious disease in ecological invasions for particular natural systems. However, a general understanding of the role that shared disease may play in invasions is lacking. Here, we develop a strategic theoretical framework to determine the role of disease, in addition to competition, in ecological invasions and the expansion of species spatial range. We investigate the effect of different disease parameters on the replacement time of a native species by an alien invader. The outcome is critically dependent on the relative effects that the disease has on the two species and less dependent on the basic epidemiological characteristics of the interaction. This framework is also used to investigate the effect of disease on the spatial spread of the invader. Our results show an interesting phenomenon where a wave of disease spreads through the landscape ahead of the wave of replacement. Keywords Disease models. Spatial. Multi-species. Ecological invasions. Squirrelpox. Travelling waves

Sally S. Bell; Andrew White; Jonathan A. Sherratt; Mike Boots

2008-01-01T23:59:59.000Z

283

Computational, statistical and graph-theoretical methods for disease mapping and cluster detection  

E-Print Network (OSTI)

Epidemiology, the study of disease risk factors in populations, emerged between the 16th and 19th centuries in response to terrifying epidemics of infectious diseases such as yellow fever, cholera and bubonic plague. ...

Wieland, Shannon Christine

2007-01-01T23:59:59.000Z

284

DCGene: a novel predicting approach of the disease related genes on functional annotation  

Science Conference Proceedings (OSTI)

Disease Candidate Genes (DCGene) is an advanced system for predicting the disease related genes, It is a novel computational approach by using the GO annotation information. The performance of the DCGene is evaluated in a set containing 1057 test samples, ...

Yuan Fang; Hui Wang

2009-09-01T23:59:59.000Z

285

South Carolina Pest Management Handbook for Field Crops -2013 SOYBEAN DISEASE CONTROL  

E-Print Network (OSTI)

-20.5 2 (42) Rust + other diseases Quilt Xcel SE Azoxystrobin + Propiconazole 14 - 21 2 (42) Rust + other

Stuart, Steven J.

286

Regulation of Drosophila eye development by the transcription factors : eyes absent and Spenito  

E-Print Network (OSTI)

During development of an adult organism from a fertilized embryo, signaling pathways are deployed reiteratively to regulate a variety of cellular processes, including cell proliferation, specification, differentiation, ...

Jemc, Jennifer Colleen

2007-01-01T23:59:59.000Z

287

NREL: News Feature - Scientists Go Eye to Eye with Research at...  

NLE Websites -- All DOE Office Websites (Extended Search)

big screen and made an almost instant discovery. "I had this image of a coarse-grained model - blue and red pipes to represent a bulk hetero-junction structure used in organic...

288

The picture of health: map-based, collaborative spatio-temporal disease tracking  

Science Conference Proceedings (OSTI)

Disease outbreaks are intimately tied to geographic locations and to times, and as a result, health-related GIS along with open, Web-based data sources are increasingly crucial for public health. One such data source, ProMED-mail, offers disease reports ... Keywords: GIS, disease tracking, geotagging, spatio-temporal

Rongjian Lan; Michael D. Lieberman; Hanan Samet

2012-11-01T23:59:59.000Z

289

Utilization of Discretization method on the diagnosis of optic nerve disease  

Science Conference Proceedings (OSTI)

The optic nerve disease is an important disease that appears commonly in public. In this paper, we propose a hybrid diagnostic system based on discretization (quantization) method and classification algorithms including C4.5 decision tree classifier, ... Keywords: Artificial neural network, C4.5 decision tree classifier, Discretization method, Hybrid systems, Least square support vector machine, Optic nerve disease, VEP signals

Kemal Polat; Sad?k Kara; Ay?egl Gven; Salih Gne?

2008-09-01T23:59:59.000Z

290

I N T H I S I S S U E Lyme disease communication  

E-Print Network (OSTI)

I N T H I S I S S U E · Lyme disease communication to countryside users · Providing public benefits in private woodlands, causes of wildfires in South Wales and communicating animal disease (Lyme) risks in rural areas within a framework of risk communication. It focuses on Lyme disease, an infection caused

291

Research Summary Assessing and communicating animal disease risks for countryside users  

E-Print Network (OSTI)

initially on Lyme disease, an infection caused by a spiral bacteria Borrelia burgdorferi that is found in a number of wild animal hosts and which can be transferred to humans by infected ticks. Lyme disease in Lyme disease resulting from changes in environmental factors mdevelop appropriate risk assessment

292

SVM feature selection for classification of SPECT images of Alzheimer's disease using spatial information  

Science Conference Proceedings (OSTI)

Alzheimer's disease is the most frequent type of dementia for elderly patients. Due to aging populations, the occurrence of this disease will increase in the next years. Early diagnosis is crucial to be able to develop more powerful treatments. Brain ... Keywords: Alzheimer's disease, Mathematical programming, Medical imaging, Support vector machines

Glenn Fung; Jonathan Stoeckel

2007-02-01T23:59:59.000Z

293

Computational intelligence for genetic association study in complex diseases: review of theory and applications  

Science Conference Proceedings (OSTI)

Comprehensive evaluation of common genetic variations through association of SNP structure with common complex disease in the genome-wide scale is currently a hot area in human genome research thanks for the recent development of the Human Genome ... Keywords: SNP, common complex diseases, computational intelligence, disease mapping, epistasis, genetic association, genetic variations, haplotype data, human genome research, single nucleotide polymorphisms

Arpad Kelemen; Athanasios V. Vasilakos; Yulan Liang

2009-03-01T23:59:59.000Z

294

Heart . Author manuscript Effects of depressive symptoms and coronary heart disease and their  

E-Print Network (OSTI)

Heart . Author manuscript Page /1 11 Effects of depressive symptoms and coronary heart disease separately in patients with coronary heart disease (CHD) and in populations healthy at study inception and CHD status. OBJECTIVE To examine effects of depressive symptoms and coronary heart disease

Paris-Sud XI, Université de

295

Eur Heart J. Author manuscript History of coronary heart disease and cognitive performance in midlife: the  

E-Print Network (OSTI)

Eur Heart J. Author manuscript Page /1 9 History of coronary heart disease and cognitive: Archana Singh-Manoux Abstract Aims Some studies show coronary heart for this association. Coronary heart disease is a global problem, with the risk of disease shown to increase as12

Paris-Sud XI, Université de

296

New England Foot and Mouth Disease Tabletop Exercise  

Science Conference Proceedings (OSTI)

The Multiscale Epidemiologic/Economic Simulation and Analysis (MESA) Decision Support System (DSS) is the product of investments that began in FY05 by the Department of Homeland Security (DHS) Science and Technology Directorate and continue today with joint funding by both DHS and the US Department of Agriculture (USDA). The DSS consists of a coupled epidemiologic/economic model, a standalone graphical user interface (GUI) that supports both model setup and post-analysis, and a Scenario Bank archive to store all content related to foreign animal disease (FAD) studies (Figure 1). The MESA epi model is an object-oriented, agent-based, stochastic, spatio-temporal simulator that parametrically models FAD outbreaks and response strategies from initial disease introduction to conclusion over local, regional, and national scales. Through its output database, the epi model couples to an economic model that calculates farm-level impacts from animal infections, responsive control strategies and loss of trade. The MESA architecture contains a variety of internal models that implement the major components of the epi simulation, including disease introduction, intra-herd spread, inter-herd spread (direct and indirect), detection, and various control strategies (movement restrictions, culling, vaccination) in a highly configurable and extensible fashion. MESA will produce both overall and daily summary statistics for the outbreak, epidemic curves, and costs associated with the outbreak. This information can be used to reconstruct and analyze the course of the outbreak. Geographical information produced by MESA can be used to produce maps and movies as visual aids to understand the distribution characteristics of a simulated outbreak.

Hullinger, P

2008-09-30T23:59:59.000Z

297

Full-spectrum disease response : beyond just the flu.  

SciTech Connect

Why plan beyond the flu: (1) the installation may be the target of bioterrorism - National Laboratory, military base collocated in large population center; and (2) International Airport - transport of infectious agents to the area - Sandia is a global enterprise and staff visit many foreign countries. In addition to the Pandemic Plan, Sandia has developed a separate Disease Response Plan (DRP). The DRP addresses Category A, B pathogens and Severe Acute Respiratory Syndrome (SARS). The DRP contains the Cities Readiness Initiative sub-plan for disbursement of Strategic National Stockpile assets.

Knazovich, Michael Ward; Cox, Warren B.; Henderson, Samuel Arthur

2010-04-01T23:59:59.000Z

298

The Diet-Heart Hypothesis: a critical appraisal of the relationship between diet and coronary artery disease  

E-Print Network (OSTI)

for Prevention of Coronary Heart Disease. JAMA. 2002;288:M. Fish consumption and coronary heart disease mortality: aacid and risk of ischemic heart disease among women. Am J

Jurewitz, Daniel L

2007-01-01T23:59:59.000Z

299

CHANGES OF ARTERIAL BLOOD PRESSURE IN ACUTE RADIATION DISEASE  

SciTech Connect

Acute experiments were done in cats and chronic experiments in dogs. The cats were subjected to whole-body x irradiation with a dose of 1500 r, and were examined on the third day after irradiation, when radiation disease was fully developed. Reflexes from the baro- and chemoreceptors were investigated, and arterial blood pressure was recorded in the irradiated cats after intravenous administration of adrenaline, noradrenaline, serotonin, acetylcholine, histamine, Regitine, atropine, or Pendiomid. Dogs were subjected to whole-body irradiation with 800 r,; changes in arterial blood pressure, which occurred after the administration of neurohormones, were investigated before and after irradiation. Pressor reflexes in irradiated cats, elicited by clamping and unclamping of both common carotid arteries, corresponded to a rise from 129.6 to 141.4 mm Hg, as compared to pressor reflexes in nonirradiated cats from 106.6 to 146. Reflexes from carotid sinus chemoreceptors evoked by 0.5% KCl were also weaker in irradiated cats. The results of both the acute and chronic experiments indicate that circulatory changes occur in radiation disease. The changes mainly involve responses of the circulatory system to neurohormones and stimulation of vascular baro- and chemoreceptors. (TCO)

Ryzewski, J.

1962-12-01T23:59:59.000Z

300

SENSITIZATION AND EXACERBATION OF ALLERGIC DISEASES BY DIESEL ENGINE PARTICLES  

DOE Green Energy (OSTI)

Most studies of the health effects of diesel exhaust have focused on the controversial issue of its role in cancer. However, recently the role of combustion products such as diesel exhaust particles (DEP) in modulating the immune response has garnered much attention. In particular the effect of DEP on allergic and asthmatic diseases has been the focus of many studies. A link between industrialization and allergic disease has long been presumed. Indeed, only 50 years after the first recorded reported case of allergy in 1819, Charles Blackely wrote that the ''hay-fever epidemic'' was associated with the movement of people from the country into the cities. Ishizaki et al. (1987) found that people in Japan living on busy roads lined with cedar trees have more allergies to cedar than residents living on similar streets with much less traffic. Since that time other epidemiological studies have reported similar findings. Kramer, et al., showed that hay fever is greater in residential areas with heavy truck traffic, while Weiland, et al., reported that allergic symptoms correlate with the distance of residences to roads with heavy traffic.

Diaz-Sanchez, David

2000-08-20T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease  

E-Print Network (OSTI)

Endogenous protein quality control machinery has long been suspected of influencing the onset and progression of neurodegenerative diseases characterized by accumulation of misfolded proteins. Huntington's disease (HD) ...

Lindquist, Susan

302

Bead-based microfluidic immunoassay for diagnosis of Johne's disease  

SciTech Connect

Microfluidics technology offers a platform for development of point-of-care diagnostic devices for various infectious diseases. In this study, we examined whether serodiagnosis of Johne s disease (JD) can be conducted in a bead-based microfluidic assay system. Magnetic micro-beads were coated with antigens of the causative agent of JD, Mycobacterium avium subsp. paratuberculosis. The antigen-coated beads were incubated with serum samples of JD-positive or negative serum samples and then with a fluorescently-labeled secondary antibody (SAB). To confirm binding of serum antibodies to the antigen, the beads were subjected to flow cytometric analysis. Different conditions (dilutions of serum and SAB, types of SAB, and types of magnetic beads) were optimized for a great degree of differentiation between the JD-negative and JD-positive samples. Using the optimized conditions, we tested a well-classified set of 155 serum samples from JD negative and JD-positive cattle by using the bead-based flow cytometric assay. Of 105 JD-positive samples, 63 samples (60%) showed higher antibody binding levels than a cut-off value determined by using antibody binding levels of JD-negative samples. In contrast, only 43-49 JD-positive samples showed higher antibody binding levels than the cut-off value when the samples were tested by commercially-available immunoassays. Microfluidic assays were performed by magnetically immobilizing a number of beads within a microchannel of a glass microchip and detecting antibody on the collected beads by laser-induced fluorescence. Antigen-coated magnetic beads treated with bovine serum sample and fluorescently-labeled SAB were loaded into a microchannel to measure the fluorescence (reflecting level of antibody binding) on the beads in the microfluidic system. When the results of five bovine serum samples obtained with the system were compared to those obtained with the flow cytometer, a high level of correlation (linear regression, r2 = 0.994) was observed. In a further experiment, we magnetically immobilized antigen-coated beads in a microchannel, reacted the beads with serum and SAB in the channel, and detected antibody binding to the beads in the microfluidic system. A strong antibody binding in JD-positive serum was detected, whereas there was only negligible binding in negative control experiments. Our data suggest that the bead-based microfluidic system may form a basis for development of an on-site serodiagnosis of JD. Key Words: Mycobacterium avium ssp. paratuberculosis, Johne s disease, microfluidics, lab-on-a-chip.

Wadhwa, Ashutosh [University of Tennessee, Center for Wildlife Health, Department of Forestry; Foote, Robert [ORNL; Shaw, Robert W [ORNL; Eda, Shigetoshi [ORNL

2012-01-01T23:59:59.000Z

303

Modifying Proteins to Combat Disease | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Higher Temperature at the Earth's Core Higher Temperature at the Earth's Core Clues about Rheumatoid Arthritis Damage Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Modifying Proteins to Combat Disease JANUARY 22, 2013 Bookmark and Share Structure of the human PRMT5:MEP50 hetero-octameric complex bound to a substrate peptide and a cofactor analog. Cartoon representations of the PRMT5 monomers are colored blue, green, wheat, and yellow, while the MEP50 molecules are in red. Highlighted in stick representation are the substrate peptide derived from histone H3 in magenta, and the cofactor analog in orange. Transmitting from one generation to the next the genetic message encoded in

304

THE BEHAVIOUR OF VASCILAR REACTIONS IN ACUTE IRRADIATION DISEASE  

SciTech Connect

Acute experiments were made with cats, and chronic experiments with dogs. The a cute experiments numbered 377 and concerned 65 rats of either sex and different weights in urethan anesthesia. Another 22 cats were used for 65 control experiments. The cats received a total dose of 1500 r from a therapeutic x-ray unit. The conditions were: distance, 60 cm; O.5 mm copper filter; 160 kv; 20 ma; 29 r/min. The cats were examined on the third day after irradiation, when the irradiation disease picture was developed. Vascular reflexes from the interoceptors of the carotid sinus were investigated after Heymans's method, reflexes from the interoceptors of spleen and intestinal loop vessels after Czernigowski's method, and reflexes from interoceptors of hind-leg vessels after the author's method. Adrenaline, noradrenaline, serotonin, acetylcho-line, potassium chloride, and lactic acid were used to stimulate interoceptors. To stimulate the proximal section of the sciatic nerve and peripheral part of the splanchnic nerve, electric current was used --3 to 6 volts, 20 ma, 20 sec. Furthermore, arterial blood pressure was measured in irradiated cats after intravenous administration of adrenaline, noradrenaline, serotonin, acetylcholine, or histamine. Experiments were also made with cats poisoned with phentolamine, atropine, or pendiomid. The experimental material was analyzed statistically. Chronic experiments numbered 165 and concerned 6 dogs. Before irradiation, the dogs were opperated upon after the author's method to enable blood pressure to be measured by intravascular technique, and subsequently standards of arterial blood pressure reaction to adrenaline, noradrenaline, serotonin, acetylcholine, and histamine were determin+d. In the experiments, the dogs received a total dose of 800 r from a therapeutic x ray unit. Conditions were: distance, 80 cm; O.5 mm Cu filter; l60 Kv; 20 ma; 21 r/min. Alrterial blood pressure reaction to the above neurohormones was investigated in the irradiated dogs daily. Experiments with dogs poisoned with phentolamine or pendiomid were also carried out. The experiments referred to showed ionizing radiation to reduce considerably reflexes from vascular chemoreceptors to neurohormones, potassium chloride, and lactic acid. In irradiated cats, pressor reflexes from carotid sinus mechanoreceptors were diminished, and so were pressor reflexes to electric stimulation of the sciatic and splanchnic nerves. Neurohormones, such as adrenaline and noradrenaline, caused in cats and dogs lower-than-standard effects. Depressor effects of serotonin were in irradiated and noniirradiated cats equal in strength. In dogs, on the other hand, pressor effects of serotonin diminished in strength with the progress of irradiation disease. Pressure fall evoked by aby acetylcholine and histamine was the same in irradiated and nonirradiated cats and dogs, but of considerably longer duration in irradiated animals. Phentolamine diminished pressor effects of adrenaline in irradiated cats and dogs, and also weakened in dogs the pressor effects of serotonin. Atropine and phentolamine increased in irradiated cats and dogs pressor effects of adrenaline and noradrenaline, and pressor effects of serotonin in dogs. It was concluded that in acute irradiation disease the adrenergic part of the autonomic nervous system, first of all sensory and vasomotor terminals, is injured. Also, preserved vasomotor reflexes, even though weakened, enable in this disease an influence to be exerted on the functional efficiency of the circulatory system. (auth)

Ryzewski, J.

1960-01-01T23:59:59.000Z

305

Heart Rate Variability in Mice with Coronary Heart Disease  

E-Print Network (OSTI)

Heart rate variability (HRV), the beat-to-beat fluctuation of the heart rate, is a noninvasive test that measures the autonomic regulation of the heart. Assessment of HRV has been shown to predict the risk of mortality in patients after an acute myocardial infarction. Recently, the Krieger lab at MIT developed genetically engineered double knockout (dKO) mice that develop coronary artery disease accompanied by spontaneous myocardial infarctions and die at a very young age. This thesis investigated whether HRV could function as a prognostic indicator in the dKO mouse. A novel method for estimating physiological state of the mouse from the electrocardiogram using an innovative activity index was developed in order to compare HRV variables at different times while controlling for physiologic state. Traditional time and frequency domain variables were used to assess the prognostic power of HRV. Results have shown that none of the HRV variables were helpful in predicting

Laurence Zapanta; Roger G. Mark

2005-01-01T23:59:59.000Z

306

doi:10.4061/2011/747861 Review Article Metabolic Syndrome, Chronic Kidney Disease, and Cardiovascular Disease: A Dynamic and Life-Threatening Triad  

E-Print Network (OSTI)

Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The metabolic syndrome (MS) and chronic kidney disease (CKD) have both become global public health problems, with increasing social and economic impact due to their high prevalence and remarkable impact on morbidity and mortality. The causality between MS and CKD, and its clinical implications, still does remain not completely understood. Moreover, prophylactic and therapeutic interventions do need to be properly investigated in this field. Herein, we critically review the existing clinical evidence that associates MS with renal disease and cardiovascular disease, as well as the associated pathophysiologic mechanisms and actual treatment options. 1.

Mrio Raimundo; Josantnio Lopes

2010-01-01T23:59:59.000Z

307

Altered mental status, an unusual manifestation of early disseminated Lyme disease: A case report  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Early disseminated Lyme disease can have a myriad of central nervous system manifestations. These run the gamut from meningitis to radiculopathy and cranial neuropathy. Here we present a case that manifested with only acute mental status change in the setting of central nervous system involvement with Lyme disease. A paucity of other central nervous system manifestations is rare, especially with positive serum and cerebrospinal fluid markers. This article underscores the importance of a high index of clinical suspicion in detection of Lyme disease related manifestations in endemic areas. Background Lyme disease is a multisystem inflammatory disease caused by spirochetes, known collectively as Borrelia burgdorferi, which are spread by the bite of infected Ixodes ticks. Lyme disease was first described in studies of an outbreak of "juvenile rheumatoid arthritis " in Connecticut [1]. It is endemic in the states of Massachusetts, Connecticut,

Shiven B Chabria; Jock Lawrason

2007-01-01T23:59:59.000Z

308

Nutrition and Biochemistry of PhospholipidsChapter 2 Stimulation of Lipases and Phospholipases in Alzheimer Disease  

Science Conference Proceedings (OSTI)

Nutrition and Biochemistry of Phospholipids Chapter 2 Stimulation of Lipases and Phospholipases in Alzheimer Disease Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry AOCS Press Downloadable pdf ...

309

Development of an ELISA to determine Aleutian mink disease parvovirus (ADV) capsid protein antibody titers.  

E-Print Network (OSTI)

??Aleutian mink disease parvovirus (ADV) is a naturally occurring, autonomous parvovirus that is capable of infecting some members of the Mustelidae family. Although this virus (more)

Pennick, Kate Elizabeth

2005-01-01T23:59:59.000Z

310

Development of a Method for the Detection of Aleutian Mink Disease Virus in Water Samples.  

E-Print Network (OSTI)

??Aleutian mink disease virus (AMDV) causes significant loss to the mink industry in Nova Scotia (NS). Contaminated water is a speculated virus source therefore my (more)

Larsen, Sophie

2013-01-01T23:59:59.000Z

311

Methods of treating parkinson's disease using viral vectors  

DOE Patents (OSTI)

Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.

Bankiewicz, Krys (Garrett Park, MD); Cunningham, Janet (Alameda, CA)

2009-05-19T23:59:59.000Z

312

Nutrition and Biochemistry of PhospholipidsChapter 11 The Benefits of Lecithin on Cardiovascular Disease  

Science Conference Proceedings (OSTI)

Nutrition and Biochemistry of Phospholipids Chapter 11 The Benefits of Lecithin on Cardiovascular Disease Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry AOCS Press Downloadable pdf of

313

Compost teas and compost amended container media for plant disease control.  

E-Print Network (OSTI)

??The primary goal of this dissertation research was to assess the use of compost for the control of several foliar and soil borne diseases commercially (more)

[No author

2002-01-01T23:59:59.000Z

314

Efficacy of compost amendments and extracts in the control of foliar disease in organic tomato production.  

E-Print Network (OSTI)

??Effects of compost amendments and extracts on tomato foliar disease severity and yield were assessed in greenhouse and field experiments. Aerated and nonaerated compost tea (more)

Murray, William Kraft.

2005-01-01T23:59:59.000Z

315

Edge effects, not connectivity, determine the incidence and development of a foliar fungal plant disease.  

Science Conference Proceedings (OSTI)

Using a model plant-pathogen system in a large-scale habitat corridor experiment, we found that corridors do not facilitate the movement of wind-dispersed plant pathogens, that connectivity of patches does not enhance levels of foliar fungal plant disease, and that edge effects are the key drivers of plant disease dynamics. Increased spread of infectious disease is often cited as a potential negative effect of habitat corridors used in conservation, but the impacts of corridors on pathogen movement have never been tested empirically. Using sweet corn (Zea mays) and southern corn leaf blight (Cochliobolus heterostrophus) as a model plant-pathogen system, we tested the impacts of connectivity and habitat fragmentation on pathogen movement and disease development at the Savannah River Site, South Carolina, USA. Over time, less edgy patches had higher proportions of diseased plants, and distance of host plants to habitat edges was the greatest determinant of disease development. Variation in average daytime temperatures provided a possible mechanism for these disease patterns. Our results show that worries over the potentially harmful effects of conservation corridors on disease dynamics are misplaced, and that, in a conservation context, many diseases can be better managed by mitigating edge effects.

Johnson, Brenda, L.; Haddad, Nick, M.

2011-08-01T23:59:59.000Z

316

Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification  

E-Print Network (OSTI)

Human societies face diverse health challenges including a rapidly aging population, rising incidence of metabolic disease, and increasing antibiotic resistance. These problems involve complex interactions between genes ...

Tong, Lily Victoria

2008-01-01T23:59:59.000Z

317

Carotenoids & Retinoids; Molecular Aspects and Health IssuesChapter 21 Carotenoids and Cadiovascular Disease  

Science Conference Proceedings (OSTI)

Carotenoids & Retinoids; Molecular Aspects and Health Issues Chapter 21 Carotenoids and Cadiovascular Disease Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pd

318

Carotenoids & Retinoids; Molecular Aspects and Health IssuesChapter 12 Lycopene and Risk of Cardiovascular Disease  

Science Conference Proceedings (OSTI)

Carotenoids & Retinoids; Molecular Aspects and Health Issues Chapter 12 Lycopene and Risk of Cardiovascular Disease Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Download

319

Follow-up Review of the Hanford Site Chronic Beryllium Disease...  

NLE Websites -- All DOE Office Websites (Extended Search)

Oversight Follow-up Review of the Hanford Site Chronic Beryllium Disease Prevention Program February 2013 Office of Safety and Emergency Management Evaluations Office of...

320

Conventional and molecular assays aid diagnosis of crop diseases and fungicide resistance  

E-Print Network (OSTI)

orchards in California. Crop Protec Ma Z, Yoshimura MA,assays aid diagnosis of crop diseases and fungicidemonitor, diagnose and quantify crop pathogens. We have also

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Analysis and restoration of a 1960s ear vacuum tube AM-FM reflex receiver  

E-Print Network (OSTI)

This thesis details the analysis, restoration, and evaluation of a 1960s era vacuum tube AM-FM reflex receiver. External influences such as tax laws necessitated clever designs to minimize the use of expensive vacuum tubes ...

Golden, Adam J

2004-01-01T23:59:59.000Z

322

Phylogeny and Taxonomy of the Round-Eared Sengis or Elephant-Shrews, Genus Macroscelides (Mammalia,  

E-Print Network (OSTI)

. pilicaudus from the Nama-Karoo in South Africa; [7]). However, genetic analyses have not yet been applied at Wlotzkasbaken, Namibia, on 25 May 2000 (photo by GBR). B (bottom). M. p. proboscideus captured in the Nama-Karoo the Nama-Karoo. doi:10.1371/journal.pone.0032410.g001 Taxonomic Revision of Macroscelides PLoS ONE | www

323

Transport Analysis of Bat-eared T_e Profile Discharges in DIII-D  

E-Print Network (OSTI)

Bull. Am. Phys. Soc. 55, 345 (2010)52nd American Physical Society Annual Meeting of Division of Plasma Physics Chicago Illinois, US, 2010999618135

Austin, M.E.

2010-08-20T23:59:59.000Z

324

TinyEARS: spying on house appliances with audio sensor nodes  

Science Conference Proceedings (OSTI)

Fine-grained awareness on how and where energy is spent is being increasingly recognized as the key to conserve energy. While several solutions to monitor the energy consumption patterns for commercial and industrial users exist, energy reporting systems ... Keywords: audio data classification, energy monitoring, house appliances, wireless audio sensor networks

Z. Cihan Taysi; M. Amac Guvensan; Tommaso Melodia

2010-11-01T23:59:59.000Z

325

New HP 1304A  

E-Print Network (OSTI)

of others will make you more productive (and more valuable!) If no one else has seen the problem, you must solve it yourself. At this stage, apply the Rules of Logical Troubleshooting. This consists of milking the instrument for all symptoms available. Use your eyes, ears and nose. Are lights lit? Readouts active? Are there any signs of heat or broken components? Are there any abnormal sounds? Pops, hissing, hum? Is there a smell associated with a particular area? Essence

Servl Ce; Info R Mati; N From; He Wlett-packard

1981-01-01T23:59:59.000Z

326

How someone with a neuromuscular disease experiences operating a PC (and how to successfully counteract that)  

Science Conference Proceedings (OSTI)

This paper describes the experiences of the first author, who has been diagnosed with the neuromuscular disease Friedreich's Ataxia more than 25 years ago, with the innovative approach to human-computer interaction characterized by the software tool ... Keywords: Friedreich's Ataxia, ambiguous keyboard, dysarthria, human-computer interaction, keyboard replacement, mouse emulator, neuromuscular disease, word prediction

Torsten Felzer, Stephan Rinderknecht

2013-10-01T23:59:59.000Z

327

A common interface to transfer data between telemedicine devices and smartphones for monitoring of chronic diseases  

Science Conference Proceedings (OSTI)

An important part of chronic patients care is continuous monitoring of relevant parameters according to a particular disease. The subject of the work is an implementation of a common interface to exchange data between various medical devices and smartphones ... Keywords: Bluetooth, Java Android programming, Java programming, chronic disease, mobile care, smartphone

Jacek Da?da; Dominik Kobylarz

2012-09-01T23:59:59.000Z

328

A medical game changer New device shows early promise for detecting heart disease  

E-Print Network (OSTI)

Fall 2012 A medical game changer New device shows early promise for detecting heart disease It as a functional test for people at high risk of developing heart disease, the leading cause of death in the United for enhancing auscultation (listening to heart sounds). Her husband, Robert Guion, was a convenient, good

Minnesota, University of

329

Interdisciplinary design of an electronic organizer for persons with alzheimer's disease  

Science Conference Proceedings (OSTI)

Because of cognitive problems, it is very difficult for individuals with Alzheimer's disease (AD) to manage their time. Consequently, they are dependent on their caregivers or use pen-and-paper organizers, both of which have limitations. A more interesting ... Keywords: alzheimer's disease, compensatory memory device, electronic organizer, interdisciplinary approach, memory deficits

Hlne Imbeault; Hlne Pigot; Nathalie Bier; Lise Gagnon; Nicolas Marcotte; Sylvain Giroux; Tamas Flp

2011-06-01T23:59:59.000Z

330

Predicting Severity of Parkinson's Disease from Speech Meysam Asgari and Izhak Shafran  

E-Print Network (OSTI)

of progression of the disease. There is a growing interest in home-based assessment tools for measuring severity applications such as in home-based assessment or in telemonitoring of Parkinson's disease. I. INTRODUCTION. Not surprisingly, there has been a growing interest in creating tools and methods for alternative home-based

Shafran, Izhak

331

Dynamic Policy Modeling for Chronic Diseases: Metaheuristic-Based Identification of Pareto-Optimal Screening Strategies  

Science Conference Proceedings (OSTI)

We present a risk-group oriented chronic disease progression model embedded within a metaheuristic-based optimization of the policy variables. Policy-makers are provided with Pareto-optimal screening schedules for risk groups by considering cost and ... Keywords: chronic disease policy analysis, decision analysis, dynamic resource allocation, health care, metaheuristics, multicriteria optimization, prevention

Marion S. Rauner; Walter J. Gutjahr; Kurt Heidenberger; Joachim Wagner; Joseph Pasia

2010-09-01T23:59:59.000Z

332

Proceedings of the 2nd workshop on lyme disease in the Southeast  

Science Conference Proceedings (OSTI)

This volume provides author prepared abstracts of oral presentation at the Second Workshop on Lyme Disease in the Southeast head in Raleigh, North Carolina September 7-9, 1993. The 33 presentations covered various aspects of the epidemic including geographical distribution of various species of ticks, transmission risks, Lyme Disease epidemiology, and taxonomic aspects.

Apperson, C.S. [ed.] [North Carolina State Univ., Raleigh, NC (United States). Dept. of Entomology; Levine, J.F. [ed.] [North Carolina State Univ., Raleigh, NC (United States). Dept. of Microbiology, Pathology, and Parasitology; Snoddy, E.L. [ed.] [Tennessee Valley Authority, Muscle Shoals, AL (United States)

1993-12-31T23:59:59.000Z

333

Projecting independent components of SPECT images for computer aided diagnosis of Alzheimer's disease  

Science Conference Proceedings (OSTI)

Finding sensitive and appropriate technologies for early detection of the Alzheimer's disease (AD) are of fundamental importance to develop early treatments. Single Photon Emission Computed Tomography (SPECT) images are non-invasive observation tools ... Keywords: Alzheimer's disease, Computer aided diagnosis, Independent Component Analysis, Supervised learning, Support vector machine

I. lvarez Illn; J. M. Grriz; J. Ramrez; D. Salas-Gonzalez; M. Lpez; F. Segovia; P. Padilla; C. G. Puntonet

2010-08-01T23:59:59.000Z

334

Differential automatic diagnosis between Alzheimer's disease and frontotemporal dementia based on perfusion SPECT images  

Science Conference Proceedings (OSTI)

Objective: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are among the most frequent neurodegenerative cognitive disorders, but their differential diagnosis is difficult. The aim of this study was to evaluate an automatic method returning ... Keywords: Alzheimer's disease, Brain SPECT, Computer-aided diagnosis, Frontotemporal dementia, k-Nearest neighbours

Jean-Franois Horn; Marie-Odile Habert; Aurlie Kas; Zoulikha Malek; Philippe Maksud; Lucette Lacomblez; Alain Giron; Bernard Fertil

2009-10-01T23:59:59.000Z

335

Neurobiology of Disease Loss of ALS2 Function Is Insufficient to Trigger Motor  

E-Print Network (OSTI)

Neurobiology of Disease Loss of ALS2 Function Is Insufficient to Trigger Motor Neuron Degeneration, Baltimore, Maryland 21205 Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, is caused by a selective loss of motor neurons in the CNS. MutationsintheALS2

Blackshaw, Seth

336

Coronary Heart Disease: Overview #1 Killer in the U.S.  

E-Print Network (OSTI)

#12;Coronary Heart Disease: Overview · #1 Killer in the U.S. · Accounts for more than one in five, the vessels that supply the heart · Disease process: coronary atherosclerosis (plagues in artery) involves flow, shortage of oxygen, pain that radiates across the chest and arms Myocardial infarction - heart

Meagher, Mary

337

Lyme Disease In New York State: Spatial Pattern At A Regional Scale  

E-Print Network (OSTI)

Lyme disease occurs commonly in New York State, but its geographic distribution is heterogeneous. For each of nine consecutive years, incidence rates from 57 New York State counties were subjected to spatial autocorrelation analysis. Although the epidemic advanced during the study period, the analyses reveal a consistent pattern of spatial dependence. The correlation distance, the distance over which incidence rates covary positively, remained near 120 km over the nine years. A local spatial analysis around Westchester County, a major disease focus, indicated that the global correlation distance matched the extent of the most intense local clustering; statistically weaker clustering extended to 200 km from Westchester. Analyzing the spatial character of the epidemic may reveal the epizootic processes underlying patterns in human infection, and may help identify a spatial scale for regional control of disease. Lyme disease remains the most frequently reported vector-borne disease in the Northern Hemisphere, and the world's most common tick-borne infection.

Stephan Glavanakov; Dennis J. White; Thomas Caraco; Andrei Lapenis; George Robinson; Boleslaw K. Szymanski; William; A. Maniatty

2001-01-01T23:59:59.000Z

338

LANL Mobile News  

NLE Websites -- All DOE Office Websites (Extended Search)

LANL Home Phonebook Calendar Video Lab team makes unique contributions to the first bionic eye The Argus II will help people blinded by the rare hereditary disease retinitis...

339

Development of polymerase chain reaction primer sets for diagnosis of Lyme disease and for species-specific identification of Lyme disease isolates by 16S rRNA signature nucleotide analysis  

E-Print Network (OSTI)

polymerase chain reaction primer sets for diagnosis of Lyme disease and for species-specific identification of Lyme disease isolates by 16S rRNA signature nucleotide analysis.

R T Marconi; C F Garon; Richard T. Marconi; Claude; F. Garon

1992-01-01T23:59:59.000Z

340

Postoperative Radiotherapy After Surgical Resection of Thymoma: Differing Roles in Localized and Regional Disease  

SciTech Connect

Purpose: To analyze the Surveillance, Epidemiology and End Results (SEER) registry data to determine the impact of postoperative radiotherapy (PORT) for thymoma and thymic carcinoma (T/TC). Methods and Materials: Patients with surgically resected localized (LOC) or regional (REG) malignant T/TC with or without PORT were analyzed for overall survival (OS) and cause-specific survival (CSS) by querying the SEER database from 1973-2005. Patients dying within the first 3 months after surgery were excluded. Kaplan-Meier and multivariate analyses with Cox proportional hazards were performed. Results: A total of 901 T/TC patients were identified (275 with LOC disease and 626 with REG disease). For all patients with LOC disease, PORT had no benefit and may adversely impact the 5-year CSS rate (91% vs. 98%, p = 0.03). For patients with REG disease, the 5-year OS rate was significantly improved by adding PORT (76% vs. 66% for surgery alone, p = 0.01), but the 5-year CSS rate was no better (91% vs. 86%, p = 0.12). No benefit was noted for PORT in REG disease after extirpative surgery (defined as radical or total thymectomy). On multivariate OS and CSS analysis, stage and age were independently correlated with survival. For multivariate CSS analysis, the outcome of PORT is significantly better for REG disease than for LOC disease (hazard ratio, 0.167; p = 0.001). Conclusions: Our results from SEER show that PORT for T/TC had no advantage in patients with LOC disease (Masaoka Stage I), but a possible OS benefit of PORT in patients with REG disease (Masaoka Stage II-III) was found, especially after non-extirpative surgery. The role of PORT in T/TC needs further evaluation.

Forquer, Jeffrey A. [Department of Radiation Oncology, Indiana University Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN (United States); Rong Nan [Department of Public Health, Indiana University Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN (United States); Fakiris, Achilles J. [Department of Radiation Oncology, Indiana University Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN (United States); Loehrer, Patrick J. [Department of Hematology Oncology, Indiana University Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN (United States); Johnstone, Peter [Department of Radiation Oncology, Indiana University Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN (United States)

2010-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Heart DiseaseHeart Disease--Learn to Love YourLearn to Love Your Michael McKee, M.D.Michael McKee, M.D.  

E-Print Network (OSTI)

Heart DiseaseHeart Disease-- Learn to Love YourLearn to Love Your HeartHeart Michael McKee, M.D.Michael McKee, M.D. March 19, 2010March 19, 2010 #12;GoalsGoals ·· Learn more about heart disease for yourself andLearn more about heart disease for yourself and for your studentsfor your students ·· Learn

Goldman, Steven A.

342

Whole-Genome Sequences of Two Borrelia afzelii and Two Borrelia garinii Lyme Disease Agent Isolates  

Science Conference Proceedings (OSTI)

Human Lyme disease is commonly caused by several species of spirochetes in the Borrelia genus. In Eurasia these species are largely Borrelia afzelii, B. garinii, B. burgdorferi, and B. bavariensis sp. nov. Whole-genome sequencing is an excellent tool for investigating and understanding the influence of bacterial diversity on the pathogenesis and etiology of Lyme disease. We report here the whole-genome sequences of four isolates from two of the Borrelia species that cause human Lyme disease, B. afzelii isolates ACA-1 and PKo and B. garinii isolates PBr and Far04.

Casjens, S.R.; Dunn, J.; Mongodin, E. F.; Qiu, W.-G.; Luft, B. J.; Fraser-Liggett, C. M.; Schutzer, S. E.

2011-12-01T23:59:59.000Z

343

Coral Health and Disease: A Comparison of Cook's and Opunohu Bays in Mo'orea,French Polynesia  

E-Print Network (OSTI)

ofcoralandcorallinealgae disease/lesions in theand nutrients. Manyspeciesofalgaealsocarry diseaseassessedforsubstrate,algae,andcoralcompositionas

Shea, Alessandra

2011-01-01T23:59:59.000Z

344

CORAL HEALTH AND DISEASE: A COMPARISON OF COOKS AND OPUNOHU BAYS IN MOOREA, FRENCH POLYNESIA  

E-Print Network (OSTI)

ofcoralandcorallinealgae disease/lesions in theand nutrients. Manyspeciesofalgaealsocarry diseaseassessedforsubstrate,algae,andcoralcompositionas

Shea, Alessandra

2011-01-01T23:59:59.000Z

345

What's Strange About Recent Events (WSARE): An Algorithm for the Early Detection of Disease Outbreaks  

Science Conference Proceedings (OSTI)

Traditional biosurveillance algorithms detect disease outbreaks by looking for peaks in a univariate time series of health-care data. Current health-care surveillance data, however, are no longer simply univariate data streams. Instead, a wealth of spatial, ...

Weng-Keen Wong; Andrew Moore; Gregory Cooper; Michael Wagner

2005-12-01T23:59:59.000Z

346

Monitoring Motor Fluctuations in Patients With Parkinson's Disease Using Wearable Sensors  

E-Print Network (OSTI)

This paper presents the results of a pilot study to assess the feasibility of using accelerometer data to estimate the severity of symptoms and motor complications in patients with Parkinson's disease. A support vector ...

Patel, Shyamal

347

Development of Regional Models that Use Meteorological Variables for Predicting Stripe Rust Disease on Winter Wheat  

Science Conference Proceedings (OSTI)

Meteorological variables can be used to predict stripe rust, a disease of wheat caused by Puccinia striiformis West., at Lind, Pullman, and Walla Walla, Washington and Pendleton, Oregon in the Pacific Northwest of the United States. Regional ...

Stella Melugin Coakley; William S. Boyd; Roland F. Line

1984-08-01T23:59:59.000Z

348

Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease  

E-Print Network (OSTI)

Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...

Desikan, Rahul S.

349

Fatty Acids in Health Promotion and Disease CausationChapter 3 Fish Oils and Stroke  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 3 Fish Oils and Stroke Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf of Chapter 3 Fish Oils and St

350

Participatory epidemiology : harnessing the HealthMap platform for community-based disease outbreak monitoring  

E-Print Network (OSTI)

Due to increasing global trade and travel along with a range of environmental factors, emerging infectious diseases such as Severe Acute Respiratory Syndrome (SARS), drug-resistant tuberculosis, and 2009 HiNi continue to ...

Freifeld, Clark

2010-01-01T23:59:59.000Z

351

Cognition in healthy aging and Parkinson's disease : structural and functional integrity of neural circuits  

E-Print Network (OSTI)

This dissertation documents how healthy aging and Parkinson's disease (PD) affect brain anatomy and physiology and how these neural changes relate to measures of cognition and perception. While healthy aging and PD are ...

Ziegler, David A. (David Allan)

2011-01-01T23:59:59.000Z

352

Trans Fats in FoodChapter 1 Trans Fatty Acid Effects on Cardiovascular Disease  

Science Conference Proceedings (OSTI)

Trans Fats in Food Chapter 1 Trans Fatty Acid Effects on Cardiovascular Disease Food Science Health Nutrition Biochemistry eChapters Food Science & Technology Health - Nutrition - Biochemistry AOCS 7D1218959FAE1721B6FEA28

353

The Antioxidant Vitamins C & EChapter 6 Serum Ascorbic Acid and Disease Prevalence  

Science Conference Proceedings (OSTI)

The Antioxidant Vitamins C & E Chapter 6 Serum Ascorbic Acid and Disease Prevalence Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf of Chapter 6 Serum Ascorbic Ac

354

The Antioxidant Vitamins C & EChapter 19 Vitamin E in Disease Prevention and Therapy  

Science Conference Proceedings (OSTI)

The Antioxidant Vitamins C & E Chapter 19 Vitamin E in Disease Prevention and Therapy Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf of Chapter 19 Vitamin E in

355

Computational studies of tau protein : implications for the pathogenesis and treatment of neurodegenerative diseases  

E-Print Network (OSTI)

Tau protein is the primary constituent of protein aggregates known as neurofibrillary tangles, a pathological hallmark of Alzheimer's disease (AD). Previous studies suggest that tau protein may play a contributing role in ...

Huang, Austin V., 1980-

2009-01-01T23:59:59.000Z

356

The Antioxidant Vitamins C & EChapter 7 Vitamin C Status and Cardiovascular Disease  

Science Conference Proceedings (OSTI)

The Antioxidant Vitamins C & E Chapter 7 Vitamin C Status and Cardiovascular Disease Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf of Chapter 7 Vitamin C Status

357

Oxidation-specific epitopes are targets of innate natural antibodies : potential implications in health and disease  

E-Print Network (OSTI)

and Disease by Meng-Yun Sandy Chou Doctor of Philosophy inSciences by Meng-Yun Sandy Chou Committee in charge:Victor Nizet Copyright Meng-Yun Sandy Chou, 2009 All rights

Chou, Meng-Yun Sandy

2009-01-01T23:59:59.000Z

358

Scenarios, personas and user stories: User-centered evidence-based design representations of communicable disease investigations  

Science Conference Proceedings (OSTI)

Purpose: Despite years of effort and millions of dollars spent to create unified electronic communicable disease reporting systems, the goal remains elusive. A major barrier has been a lack of understanding by system designers of communicable disease ... Keywords: Communicable disease reporting, Human centered design, Information workflow, Personas, Public health informatics

Anne M. Turner, Blaine Reeder, Judith Ramey

2013-08-01T23:59:59.000Z

359

GMM based SPECT image classification for the diagnosis of Alzheimer's disease  

Science Conference Proceedings (OSTI)

We present a novel classification method of SPECT images based on Gaussian mixture models (GMM) for the diagnosis of Alzheimer's disease. The aims of the model-based approach for density estimation is to automatically select regions of interest (ROIs) ... Keywords: 87.19.xr, 87.57.R-, 87.57.nm, 87.57.uh, Alzheimer's disease, EM algorithm, Gaussian mixture model, SPECT, Support vector machines (SVMs)

J. M. Grriz; F. Segovia; J. Ramrez; A. Lassl; D. Salas-Gonzalez

2011-03-01T23:59:59.000Z

360

Diagnostic evaluation of a multiplexed RT-PCR microsphere array assay for the detection of foot-and-mouth disease virus and look-alike disease viruses  

SciTech Connect

A high-throughput multiplexed assay was developed for the differential laboratory diagnosis of foot-and-mouth disease virus (FMDV) from viruses which cause clinically similar diseases of livestock. This assay simultaneously screens for five RNA and two DNA viruses using multiplexed reverse transcription PCR (mRT-PCR) amplification coupled with a microsphere hybridization array and flow-cytometric detection. Two of the seventeen primer-probe sets included in this multiplex assay were adopted from previously characterized real-time RT-PCR (rRT-PCR) assays for FMDV. The diagnostic accuracy of the mRT-PCR was evaluated using 287 field samples, including 248 (true positive n= 213, true negative n=34) from suspect cases of foot-and-mouth disease collected from 65 countries between 1965 and 2006 and 39 true negative samples collected from healthy animals. The mRT-PCR assay results were compared with two singleplex rRT-PCR assays, using virus isolation with antigen-ELISA as the reference method. The diagnostic sensitivity of the mRT-PCR assay for FMDV was 93.9% [95% C.I. 89.8-96.4%], compared to 98.1% [95% C.I. 95.3-99.3%] for the two singleplex rRT-PCR assays used in combination. In addition, the assay could reliably differentiate between FMDV and other vesicular viruses such as swine vesicular disease virus and vesicular exanthema of swine virus. Interestingly, the mRT-PCR detected parapoxvirus (n=2) and bovine viral diarrhea virus (n=2) in clinical samples, demonstrating the screening potential of this mRT-PCR assay to identify viruses in FMDV-negative material not previously recognized using focused single-target rRT-PCR assays.

Hindson, B J; Reid, S M; Baker, B R; Ebert, K; Ferris, N P; Bentley Tammero, L F; Lenhoff, R J; Naraghi-Arani, P; Vitalis, E A; Slezak, T R; Hullinger, P J; King, D P

2007-07-26T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Epidemiological and Clinical Features of 1,149 Persons with Lyme Disease Identified by Laboratory-Based Surveillance in Connecticut  

E-Print Network (OSTI)

3,098 persons with suspected Lyme disease; 1,149 were defined as cases. Lyme disease incidence in Connecticut towns ranged from none to 1,407 cases per 100,000 population in 1985. A comparison of 1985 data with data from 1977 epidemiologic studies indicated that incidence increased by 129 percent to 453 percent in towns previously known to be endemic for Lyme disease and that Lyme disease had spread northward into towns thought to be free of Lyme disease in 1977. Children aged five to 14 years had the highest incidence. Of persons with Lyme disease, 83 percent had erythema migrans, 24 percent had arthritis, 8 percent had neurologic sequelae, and 2 percent had cardiac sequelae. The distribution of symptoms was age-dependent: case-persons Lyme disease is increasing in incidence and geographic distribution in Connecticut. Of those with Lyme disease, children may be more likely than adults to develop arthritis and have it as their first major disease manifestation. Lyme disease, discovered in 1975 in Connecticut, is now endemic in at least 19

Lyle R. Petersen; A Anne H. Sweeney; Patricia J. Checko; C Louis; A. Magnarelli, Ph.D.; Patricia A. Mshar; C Robert; A. Gunn; James; L. Hadler

1989-01-01T23:59:59.000Z

362

Eyes Wide Open - Optimising Cosmological Surveys in a Crowded Market  

E-Print Network (OSTI)

Optimising the major next-generation cosmological surveys (such as {\\em SNAP, KAOS etc...}) is a key problem given our ignorance of the physics underlying cosmic acceleration and the plethora of surveys planned. We propose a Bayesian design framework which (1) maximises the discrimination power of a survey without assuming any underlying dark energy model, (2) finds the best niche survey geometry given current data and future competing experiments, (3) maximises the cross-section for serendipitous discoveries and (4) can be adapted to answer specific questions (such as `is dark energy dynamical?'). Integrated Parameter Space Optimisation (IPSO) is a design framework that integrates projected parameter errors over an entire dark energy parameter space and then extremises a figure of merit (such as Shannon entropy gain which we show is stable to off-diagonal covariance matrix perturbations) as a function of survey parameters using analytical, grid or MCMC techniques. We discuss examples where the optimisation can be performed analytically. IPSO is thus a general, model-independent and scalable framework that allows us to appropriately use prior information to design the best possible surveys.

Bruce A. Bassett

2004-07-12T23:59:59.000Z

363

Safety Bulletin 2006-06: Preventing Eye Injuries  

NLE Websites -- All DOE Office Websites (Extended Search)

If you are working with chemicals, you should wear goggles. If you are working near welding, lasers, ultraviolet light, or fiber optics, you must use special-purpose safety...

364

The Solar Dynamics Observatory: Your eye on the Sun  

Science Conference Proceedings (OSTI)

The Solar Dynamics Observatory (SDO) was launched on February 11, 2010. The instruments on SDO measure the changes in the Sun that cause Space Weather, from power outages, to navigation problems, and satellite drag. EVE measures the Heartbeat of Space ...

W. Dean Pesnell

2011-03-01T23:59:59.000Z

365

Automatic Template Matching Method for Tropical Cyclone Eye Fix  

Science Conference Proceedings (OSTI)

A time-honored way of finding, or fixing, the center of a tropical cyclone (TC) is to overlay templates of spirals onto a printout of radar or satellite image. Modern methods, however, mostly focus on wind field analysis, or other motion vector techniques. ...

Wong Ka Yan; Yip Chi Lap; Li Ping Wah; Tsang Wai Wan

2004-08-01T23:59:59.000Z

366

A Hybrid Fuzzy Approach for Human Eye Gaze Pattern Recognition  

Science Conference Proceedings (OSTI)

Face perception and text reading are two of the most developed visual perceptual skills in humans. Understanding which features in the respective visual patterns make them differ from each other is very important for us to investigate the correlation ...

Dingyun Zhu; B. Sumudu Mendis; Tom Gedeon; Akshay Asthana; Roland Goecke

2009-07-01T23:59:59.000Z

367

Relevance of interest points for eye position prediction on videos  

E-Print Network (OSTI)

", denoted STIP in the following. STIP are points which are both relevant in space and time. These points specic points which can be related to spatio- temporal events in an image. STIP detection is performed. Typical values of s and t are respectively 1.5 and 1.2. In order to highlight STIP, dierent criteria have

Paris-Sud XI, Université de

368

Structure of the Eye and Eyewall of Hurricane Hugo (1989)  

Science Conference Proceedings (OSTI)

On 15 September 1989, one of NOAAs WP-3D research aircraft, N42RF [lower aircraft (LA)], penetrated the eyewall of Hurricane Hugo. The aircraft had an engine fail in severe turbulence while passing the radius of maximum wind and before entering ...

Frank D. Marks; Peter G. Black; Michael T. Montgomery; Robert W. Burpee

2008-04-01T23:59:59.000Z

369

Ministry eyes 3 ITER-related facilities for Aomori Prefecture  

E-Print Network (OSTI)

-generation reactors. The ministry also wants to drastically remodel the fusion plasma research device called JT-60

370

Characterization of split ends function during Drosophila eye development  

E-Print Network (OSTI)

Conserved signal transduction pathways coordinate all aspects of metazoan development, including cell fate specification, differentiation, and growth. Rather than functioning as completely independent modules, signaling ...

Doroquez, David Bagon

2007-01-01T23:59:59.000Z

371

Beauty is in the Eye of the Inspector  

E-Print Network (OSTI)

at 1.56 Isc, but Section 110.3 says to follow the product labels. Any installer facing this quandary from the National Fire Protection Association (NFPA) · 800-344-3555 or 617-770-3000 · www.nfpa.org www

Johnson, Eric E.

372

The Neutrino Eye: A Megaton Low Energy Neutrino  

E-Print Network (OSTI)

, despite the evident truth of that statement, the history of the water Cherenkov detectors demonstrates requirements. After all, there are million ton oil tankers, and there are oil platforms of much larger.4.4 Supernovae Out to 2Mpc The entire history of extra­solar neutrino astronomy consists of the the few second

Learned, John

373

Retinal Instrument for Removing Scar Tissue from the Eye  

Surgeons currently peel it with an instrument that can result ... Brian R. DUrso, Edward Chaum, ... Measurement Science and Systems

374

Undercover: authentication usable in front of prying eyes  

Science Conference Proceedings (OSTI)

A number of recent scams and security attacks (phishing, spyware, fake terminals, ...) hinge on a crook's ability to observe user behavior. In this paper, we describe the design, implementation, and evaluation of a novel class of user authentication ... Keywords: multisensory processes, security, usability

Hirokazu Sasamoto; Nicolas Christin; Eiji Hayashi

2008-04-01T23:59:59.000Z

375

Eye-In-Hand Visual Servoing Curriculum for Young Students  

E-Print Network (OSTI)

It is never too early to introduce students to robotics. Inspired by courses that use Lego Mindstorms as platform, by the huge success of the FIRST competition, and by the interest and enthusiasm of many local robotics ...

Rus, Daniela L.

376

National Eye Institute A Business Case Built From Personal Experience  

E-Print Network (OSTI)

mission accomplishment needs without acquiring additional office space by expanding its telework hoteling supplies · Travel (time and money) · Utilities #12;Added Benefits to Organizations · Recruit and retain

Bandettini, Peter A.

377

Molecular restrictions for human eye irritation by chemical vapors  

E-Print Network (OSTI)

and reactive airborne chemicals. Pharmacol. Toxicol. 1998;WL. Chemesthesis: The Common Chemical Sense. In: Finger TE,MH. Quantification of chemical vapors in chemosensory

Cometto-Muniz, J. Enrique; Cain, William S.; Abraham, Michael H.

2005-01-01T23:59:59.000Z

378

Ecomorphology of the eyes and skull in zooplanktivorous labrid fishes  

E-Print Network (OSTI)

morphometrics (Table 1). The size range across individuals is 44­255 mm standard length. The examinations for body size, we measured standard length, body depth (at the level just anterior to the dorsal fin, sd standard deviation, SL standard length. Also see Fig. 2 BW in [g], all other measurements in [mm

Wainwright, Peter C.

379

With a Merchant's Eye: The Mecenatismo of Paolo Cassotti.  

E-Print Network (OSTI)

??Art History M.A. This thesis examines the patronage strategies of Paolo Cassotti, a wealthy wool merchant living in Venetian-dominated Bergamo in the early Cinquecento. Cassotti (more)

DiMarzo, Michelle

2010-01-01T23:59:59.000Z

380

NREL: News Feature - NREL Adds Eyes, Brains to Occupancy Detection  

NLE Websites -- All DOE Office Websites (Extended Search)

level (sedentary or active), and it communicates this information with building automation systems via standard protocols. Credit: Dennis Schroeder It's a gnawing frustration...

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Rail deregulation eyed for impact on coal rates  

SciTech Connect

Captive shippers who depend on a single line to move their coal supplies want protection written into any railroad deregulation legislation. Debate over this issue is expected to be heated. The Interstate Commerce Commission (ICC), meanwhile, is looking more favorably at the problems of utilities and accepts a compromise measure that sets a rate hike level which would trigger an ICC investigation. Debate in Congressional Committees will focus on the lack of competition in coal shipment and the impact this will have on the customers of coal-fired power plants. Long-term agreements are suggested as a way to limit regulation and allow the Federal government to focus on helping the railroads become more efficient. The legislative action was prompted by an ICC decision to roll back railroad freight rates paid by two utilities and a steel company. (DCK)

Not Available

1980-05-01T23:59:59.000Z

382

NIST Test Proves 'The Eyes Have It' for ID Verification  

Science Conference Proceedings (OSTI)

... technologies from 10 different providers. This represents an order of magnitude expansion of the industry over the past five years. ...

2010-12-28T23:59:59.000Z

383

An Eye on Energy Performance - Provider, March 2011  

NLE Websites -- All DOE Office Websites (Extended Search)

buildings: one is brand new with all the latest energy-efficient windows, lighting, and insulation. The second building plods along using older technologies installed 20 years...

384

NETL: Releases & Briefs - In the Eye of the Beholder: NETL's...  

NLE Websites -- All DOE Office Websites (Extended Search)

interact with it in very natural, multi-sensory ways," Halow said. In collaboration with Ames Laboratory, NETL is developing the CAVE-like facility into a science laboratory and...

385

Nonlinear Dynamics of Infectious Diseases Transfer with Possible Applications for Tubercular Infection  

E-Print Network (OSTI)

In this paper, we model a nonlinear dynamics of infectious diseases transfer. Particularly, we study possible applications to tubercular infection in models with different profiles (peak values) of the population density dependence on spatial coordinates. Our approach is based on the well known method of instantons which has been used by the authors to describe kinetics of adiabatic chemical reactions as a function of the heat-bath temperature and other system parameters. In our approach, we use "social temperature" T as one of the controlling parameters. Increase of T leads to acceleration of the infectious diseases transfer. The "blockage" effect for the infectious diseases transfer has been demonstrated in the case when peak values (in the population density) are equal to one and under condition that the "social temperature" is low. Existence of such effect essentially depends from environment "activity" (social and prophylactic). Results of our modeling qualitatively meet the tuberculosis dynamic spread d...

Krevchik, V D; Dahnovsky, Yu I; Semenov, M B; Shcherbakova, E V; Yamamoto, Kenji

2007-01-01T23:59:59.000Z

386

Sci Protek Signs Licensing Deal for Technology that Reduces Plant Disease |  

NLE Websites -- All DOE Office Websites (Extended Search)

Sci Protek Signs Licensing Deal for Technology that Reduces Plant Disease Sci Protek Signs Licensing Deal for Technology that Reduces Plant Disease January 06, 2011 A California based small business, Sci Proteck, Inc, has recently licensed technology developed at the Department of Energy's Oak Ridge National Laboratory (ORNL) and the University of Chicago (UChicago) to protect plants from crop diseases. Research on this new method for inducing plant pathogen resistance began in 2005 following a grant from the National Science Foundation and research support from the Office of Biological and Environmental Research of the U.S. Department of Energy. Principal developers include Timothy Tschaplinski at ORNL and Drs. Jean Greenberg and Ho Won Jung at the UChicago. ORNL and UChicago entered into an Inter-Institutional Agreement for licensing, patent prosecution, and royalty sharing.

387

Geek-Up[04.01.2011]: A Discovery to Fight Cancer and Other Diseases |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

4.01.2011]: A Discovery to Fight Cancer and Other Diseases 4.01.2011]: A Discovery to Fight Cancer and Other Diseases Geek-Up[04.01.2011]: A Discovery to Fight Cancer and Other Diseases April 1, 2011 - 5:52pm Addthis Two structures of the Mre11-Rad50 complex were solved independently and overlaid, further revealing a flexible hinge in Rad50 near the Mre11 binding site | Courtesy of Lawrence Berkeley National Laboratory Two structures of the Mre11-Rad50 complex were solved independently and overlaid, further revealing a flexible hinge in Rad50 near the Mre11 binding site | Courtesy of Lawrence Berkeley National Laboratory Niketa Kumar Niketa Kumar Public Affairs Specialist, Office of Public Affairs What does this mean for me? Researchers discovered that a cell's speedy ability to repair damaged DNA relies on the remarkable flexibility of a molecular motor.

388

A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm  

SciTech Connect

The 20th century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and water borne illnesses are frequent, multi-drug resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the pastincluding the intense focus on individual genes and proteins typical of molecular biologyhave not been sufficient to address these challenges. The first decade of the 21st century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program we think that the time is at hand to redefine the pathogen-host research paradigm.

Aderem, Alan; Adkins, Joshua N.; Ansong, Charles; Galagan, James; Kaiser, Shari; Korth, Marcus J.; Law, G. L.; McDermott, Jason E.; Proll, Sean; Rosenberger, Carrie; Schoolnik, Gary; Katze, Michael G.

2011-02-01T23:59:59.000Z

389

Development of a Vaccine for Bacterial Kidney Disease in Salmon, 1986 Annual Report.  

DOE Green Energy (OSTI)

Bacterial kidney disease (BRD) has been and remains a chronic contributory problem limiting the productivity of salmon of the Columbia River Basin. Control of this disease will not come easily, but it would lead to a tremendous increase in the health and numbers of salmon populations. Vaccination of salmon of Renibacterium salmoninarum (KDB) is a potentially successful method of controlling this disease. To date, however, no successful vaccine has been developed for general use. A possible solution to this problem,and thus the goal of this research, is to isolate the antigenic components of KDB and enhance their ability to activate the host defenses. This will be accomplished by the chemical modification of these antigens with potent immunomodulatory substances. These modified antigens will then be tested for their effectiveness in inducing immunity to BKD and thereby preventing the disease. The goal of the project's third year was to test the immunogenicity and prophylactic value in coho salmon (Oncorhynchus kisutch) of various chemical conjugates of Renibacterium salmoninarum cells and major antigens. This was accomplished by assessing the serum antibody response, the cellular immune response (cellular proliferation), and the kinetics of mortality after Lethal injections of the bacterium. An important facet of this research is the identification and isolation of virulence factors. These studies are not only important to the dissection of the mechanism of pathogenesis of bacterial kidney disease, but the purification of such a factor(s) will insure the production of a more potent vaccine. The studies completed this year have: (1) identified antigenic material which protect; (2) identified antigenic material which can exacerbate the disease; (3) identified a possibly major mechanism of pathogenesis via the interference with antibody; (4) the general ability to produce delineated a western blot technique for identification of infected fish; (5) described the use of monoclonal antibodies for antigenic analysis; and (6) identified an unusual and dramatic effect of R. salmoninarum cells on phagocytic function.

Kaattari, Stephen L.

1987-06-01T23:59:59.000Z

390

Gas Bubble Disease Monitoring and Research of Juvenile Salmonids : Annual Report 1996.  

DOE Green Energy (OSTI)

This document describes the project activities 1996--1997 contract year. This report is composed of three chapters which contain data and analyses of the three main elements of the project: field research to determine the vertical distribution of migrating juvenile salmonids, monitoring of juvenile migrants at dams on the Snake and Columbia rivers, and laboratory experiments to describe the progression of gas bubble disease signs leading to mortality. The major findings described in this report are: A miniature pressure-sensitive radio transmitter was found to be accurate and precise and, after compensation for water temperature, can be used to determine the depth of tagged-fish to within 0.32 m of the true depth (Chapter 1). Preliminary data from very few fish suggest that depth protects migrating juvenile steelhead from total dissolved gas supersaturation (Chapter 1). As in 1995, few fish had any signs of gas bubble disease, but it appeared that prevalence and severity increased as fish migrated downstream and in response to changing gas supersaturation (Chapter 2). It appeared to gas bubble disease was not a threat to migrating juvenile salmonids when total dissolved gas supersaturation was < 120% (Chapter 2). Laboratory studies suggest that external examinations are appropriate for determining the severity of gas bubble disease in juvenile salmonids (Chapter 3). The authors developed a new method for examining gill arches for intravascular bubbles by clamping the ventral aorta to reduce bleeding when arches were removed (Chapter 3). Despite an outbreak of bacterial kidney disease in the experimental fish, the data indicate that gas bubble disease is a progressive trauma that can be monitored (Chapter 3).

Maule, Alec G.; Beeman, John W.; Hans, Karen M.; Mesa, M.G.; Haner, P.; Warren, J.J. [Geological Survey, Cook, WA (United States). Columbia River Research Lab.

1997-10-01T23:59:59.000Z

391

Independent Oversight Inspection of the Hanford Site Chronic Beryllium Disease Prevention Program  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

the the Hanford Site Chronic Beryllium Disease Prevention Program June 2010 Office of Independent Oversight Office of Health, Safety and Security Office of Health, Safety and Security HSS x Hanford Site Chronic Beryllium Disease Prevention Program | i Abbreviations iii Executive Summary v 1 Introduction 1 2 Management and Oversight 3 3 Findings Requiring Corrective Action 14 4 Conclusions and Cross-Cutting Opportunities for Improvement 17 Appendix A - Supplemental Information 23 Appendix B - Background Information 26 Appendix C - AdvanceMed Hanford Beryllium Medical Support Program 32 Appendix D - CH2M-Hill Plateau Remediation Company 48 Appendix E - Mission Support Alliance 57 Appendix F - Washington Closure Hanford 71

392

Integrating domain knowledge with statistical and data mining methods for high-density genomic SNP disease association analysis  

Science Conference Proceedings (OSTI)

Genome-wide association studies can help identify multi-gene contributions to disease. As the number of high-density genomic markers tested increases, however, so does the number of loci associated with disease by chance. Performing a brute-force test ... Keywords: Data integration, Data mining, False discovery rate (FDR), Genome-wide association (GWA), Pathway-based disease association, Single nucleotide polymorphisms (SNP)

Valentin Dinu; Hongyu Zhao; Perry L. Miller

2007-12-01T23:59:59.000Z

393

Determining Progression in Glaucoma Using Visual Fields  

Science Conference Proceedings (OSTI)

The standardized visual field assessment, which measures visual function in 76 locations of the central visual area, is an important diagnostic tool in the treatment of the eye disease glaucoma. It helps determine whether the disease is stable or progressing ...

Andrew Turpin; Eibe Frank; Mark Hall; Ian H. Witten; Chris A. Johnson

2001-04-01T23:59:59.000Z

394

Predicting Conversion from Mild Cognitive Impairment to Alzheimers Disease using Partially Ordered Models of Neuopsychological Measurements.  

E-Print Network (OSTI)

??Background: Mild cognitive impairment (MCI) is a risk factor for conversion to Alzheimers disease (AD). Objectives: To identify predictors of the conversion of MCI to (more)

Yang, Yan

2011-01-01T23:59:59.000Z

395

Carotenoids & Retinoids; Molecular Aspects and Health IssuesChapter 17 Vitamin A in Health and Disease in Developing Countries  

Science Conference Proceedings (OSTI)

Carotenoids & Retinoids; Molecular Aspects and Health Issues Chapter 17 Vitamin A in Health and Disease in Developing Countries Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press ...

396

General Counsel Legal Interpretation Regarding Medical Removal Protection Benefits Pursuant to 10 CFR Part 850, Chronic Beryllium Disease Prevention Program  

Energy.gov (U.S. Department of Energy (DOE))

The following document is the Office of the General Counsel (GC) interpretation regarding Medical Removal Protection Benefits Pursuant to 10 CFR Part 850, Chronic Beryllium Disease Prevention Program.

397

Discovering genes-diseases associations from specialized literature using the grid  

Science Conference Proceedings (OSTI)

This paper proposes a novel method for text mining on the Grid, aimed at pointing out hidden relationships for hypothesis generation and suitable for semi-interactive querying. The method is based on unsupervised clustering and the outputs are visualized ... Keywords: Grid, genes-diseases association, knowledge discovery, text mining, unsupervised clustering

Alberto Faro; Daniela Giordano; Francesco Maiorana; Concetto Spampinato

2009-07-01T23:59:59.000Z

398

Higher coronary heart disease and heart attack morbidity in Appalachian coal mining regions  

SciTech Connect

This study analyzes the U.S. 2006 Behavioral Risk Factor Surveillance System survey data (N = 235,783) to test whether self-reported cardiovascular disease rates are higher in Appalachian coal mining counties compared to other counties after control for other risks. Dependent variables include self-reported measures of ever (1) being diagnosed with cardiovascular disease (CVD) or with a specific form of CVD including (2) stroke, (3) heart attack, or (4) angina or coronary heart disease (CHD). Independent variables included coal mining, smoking, BMI, drinking, physician supply, diabetes co-morbidity, age, race/ethnicity, education, income, and others. SUDAAN Multilog models were estimated, and odds ratios tested for coal mining effects. After control for covariates, people in Appalachian coal mining areas reported significantly higher risk of CVD (OR = 1.22, 95% CI = 1.14-1.30), angina or CHO (OR = 1.29, 95% C1 = 1.19-1.39) and heart attack (OR = 1.19, 95% C1 = 1.10-1.30). Effects were present for both men and women. Cardiovascular diseases have been linked to both air and water contamination in ways consistent with toxicants found in coal and coal processing. Future research is indicated to assess air and water quality in coal mining communities in Appalachia, with corresponding environmental programs and standards established as indicated.

Hendryx, M.; Zullig, K.J. [West Virginia University, Morgantown, WV (United States). Dept. of Community Medicine

2009-11-15T23:59:59.000Z

399

DISMON: Using Social Web and Semantic Technologies to Monitor Diseases in Limited Environments  

Science Conference Proceedings (OSTI)

Information technology and, more precisely, the internet represent challenges and opportunities for medicine. Technology-driven medicine has changed how practitioners perform their roles in and medical information systems have recently gained momentum ... Keywords: Crawler, Diseases, Limited Environments, Medical Prediction, Ontology, Semantic Technologies, Social Web

Ricardo Colomo-Palacios; ngel Garca-Crespo; Juan Miguel Gmez-Berbs; ngel M. Lagares-Lemos; Miguel Lagares-Lemos

2011-01-01T23:59:59.000Z

400

A set of ontologies to drive tools for the control of vector-borne diseases  

Science Conference Proceedings (OSTI)

We are developing a set of ontologies dealing with vector-borne diseases as well as the arthropod vectors that transmit them. After building ontologies for mosquito and tick anatomy we continued this project with an ontology of insecticide resistance ... Keywords: Anatomy, Arthropod vector, Database, Decision support system, Insecticide resistance, Malaria, Mosquito, Tick, Transmission

Pantelis Topalis; Emmanuel Dialynas; Elvira Mitraka; Elena Deligianni; Inga Siden-Kiamos; Christos Louis

2011-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Fracture, aging, and disease in bone J.W. Ager III  

E-Print Network (OSTI)

Fracture, aging, and disease in bone J.W. Ager III Materials Sciences Division, Lawrence Berkeley-known increase with age in fracture risk of human bone is essential. This also represents a challenge from accompanying the process of aging using appropriate multiscale experimental methods and relating them

Ritchie, Robert

402

Genomics-enabled sensor platform for rapid detection of viruses related to disease outbreak.  

Science Conference Proceedings (OSTI)

Bioweapons and emerging infectious diseases pose growing threats to our national security. Both natural disease outbreak and outbreaks due to a bioterrorist attack are a challenge to detect, taking days after the outbreak to identify since most outbreaks are only recognized through reportable diseases by health departments and reports of unusual diseases by clinicians. In recent decades, arthropod-borne viruses (arboviruses) have emerged as some of the most significant threats to human health. They emerge, often unexpectedly, from cryptic transmission foci causing localized outbreaks that can rapidly spread to multiple continents due to increased human travel and trade. Currently, diagnosis of acute infections requires amplification of viral nucleic acids, which can be costly, highly specific, technically challenging and time consuming. No diagnostic devices suitable for use at the bedside or in an outbreak setting currently exist. The original goals of this project were to 1) develop two highly sensitive and specific diagnostic assays for detecting RNA from a wide range of arboviruses; one based on an electrochemical approach and the other a fluorescent based assay and 2) develop prototype microfluidic diagnostic platforms for preclinical and field testing that utilize the assays developed in goal 1. We generated and characterized suitable primers for West Nile Virus RNA detection. Both optical and electrochemical transduction technologies were developed for DNA-RNA hybridization detection and were implemented in microfluidic diagnostic sensing platforms that were developed in this project.

Brozik, Susan Marie; Manginell, Ronald Paul; Moorman, Matthew Wallace; Xiao, Xiaoyin; Edwards, Thayne L.; Anderson, John Moses; Pfeifer, Kent Bryant; Branch, Darren W.; Wheeler, David Roger; Polsky, Ronen; Lopez, DeAnna M.; Ebel, Gregory D. [Colorado State University; Prasad, Abhishek N. [Colorado State University; Brozik, James A. [Washington State University; Rudolph, Angela R. [Washington State University; Wong, Lillian P. [Washington State University

2013-09-01T23:59:59.000Z

403

Scintigraphic evaluation of Lyme disease: Gallium-67 imaging of Lyme myositis  

Science Conference Proceedings (OSTI)

A patient suffering from Lyme disease had cardiac conduction abnormalities, symptoms of arthritis, and myalgia. A Ga-67 image showed evidence of endomyocarditis, but intense skeletal muscle uptake pointed to Lyme myositis. Reference is made to two other case reports of Lyme myositis.

Kengen, R.A.; v.d. Linde, M.; Sprenger, H.G.; Piers, D.A. (Univ. Hospital, Groningen (Netherlands))

1989-10-01T23:59:59.000Z

404

Discovery of temporal variation of arsenic in a historical blackfoot disease territory by time series analysis  

Science Conference Proceedings (OSTI)

Time series analysis is useful tool for extracting interesting pattern from ordered sequence of observations. The Chianan Blackfoot disease region was selected as study area, and the monitoring data of arsenic in groundwater during the period of 2003 ... Keywords: arsenic, data mining, groundwater management, time series analysis, water quality

Jan-Yee Lee; Ting-Nien Wu

2009-08-01T23:59:59.000Z

405

Discovery of Temporal Variation of Arsenic in a Historical Blackfoot Disease Territory by Time Series Analysis  

Science Conference Proceedings (OSTI)

Time series analysis is useful tool for extracting interesting pattern from ordered sequence of observations. The Chianan Blackfoot disease region was selected as study area, and the monitoring data of arsenic in groundwater during the period of 2003 ... Keywords: groundwater management, data mining, time series analysis, arsenic, water quality

Jan-Yee Lee; Ting-Nien Wu

2009-08-01T23:59:59.000Z

406

NMF-Based analysis of SPECT brain images for the diagnosis of alzheimer's disease  

Science Conference Proceedings (OSTI)

This paper offers a computer-aided diagnosis (CAD) technique for early diagnosis of Alzheimer's disease (AD) by means of single photon emission computed tomography (SPECT) image classification The SPECT database for different patients is analyzed ... Keywords: biomedical engineering, image classification, non-negative matrix factorization (NMF), support vector machines (SVM)

Pablo Padilla; Juan-Manuel Grriz; Javier Ramrez; Elmar Lang; Rosa Chaves; Fermin Segovia; Ignacio lvarez; Diego Salas-Gonzlez; Miriam Lpez

2010-06-01T23:59:59.000Z

407

Classification of SPECT Images of Normal Subjects versus Images of Alzheimer's Disease Patients  

Science Conference Proceedings (OSTI)

This work aims at providing a tool to assist the interpretation of SPECT images for the diagnosis of Alzheimer's Disease (AD). Our approach is to test classifiers, which uses the intensity values of the images, without any prior information. Such a classifier ...

Jonathan Stoeckel; Grgoire Malandain; Octave Migneco; Pierre Malick Koulibaly; Philippe Robert; Nicholas Ayache; Jacques Darcourt

2001-10-01T23:59:59.000Z

408

MAPKKKa is a positive regulator of cell death associated with both plant immunity and disease  

E-Print Network (OSTI)

cell death (the hypersensitive response; HR) also occurs in disease-resistant plants, but this response kinase kinase kinase gene (MAPKKKa) that is required for the HR and resistance against Pseudomonas P. syringae infection. Over- expression of MAPKKKa in leaves activated MAPKs and caused pathogen

Pawlowski, Wojtek

409

Why my disease is important: metrics of disease occurrence used in the introductory sections of papers in three leading general medical journals in 1993 and 2003  

E-Print Network (OSTI)

, et al: Population health metrics: crucial inputs to the development of evidence for health policy. Popul Health Metr 2003, 1:6. 2. Murray CJL, Frenk J: Health metrics and evaluation: strengthening the science. Lancet 2008, 371:1191-9. 3. Reynolds K... , Lewis LB, Nolen , et al: Alcohol Consumption and Risk of Stroke: A Meta-analysis. J Am Med Assoc 2003, 289:579-88. 4. Gross C, Anderson GF, Powe NR: The relation between funding by the national institutes of health and the burden of disease. N Engl J Med...

Gouda, Hebe N; Powles, John W

2011-05-23T23:59:59.000Z

410

Development of a Vaccine for Bacterial Kidney Disease in Salmon, 1985 Annual Report.  

DOE Green Energy (OSTI)

Bacterial kidney disease (BRD) has been and remains a chronic contributory problem limiting the productivity of salmon in the Columbia River Basin. Control of this disease will not come easily, but it would lead to a tremendous increase in the health and numbers of salmon populations. Vaccination of salmon to Renibacterium salmoninarum (KDB) is a potentially successful method of controlling this disease. To date, however, no successful vaccine has been developed for general use. A possible solution to this problem, and thus the goal of this research, is to isolate the antigenic components of KDB and enhance their ability to activate the host defenses. This will be accomplished by the chemical modification of these antigens with potent immunomodulatory substances. These modified antigens will then be tested for their effectiveness in inducing immunity to BKD and thereby preventing the disease. The goal of the project's second year was to chemically modify the major antigens of Renibacteirium salmoninarum, immunize coho salmon (Oncorhynchus kisutch), and to test the immunogenicity of the preparations used. Immunogenicity of the antigenic material was tested by (1) admixture experiments, using whole KD cells with muramyl dipepetide, Vibrio anguillarum extract, E. coli lipopolysaccharide, or Mycobacterium tuberculosis in Freund's complete adjuvant. In addition to these goals a number of important techniques have been developed in order to facilitate the production of the vaccine. These procedures include: (1) the use of the soluble antigen for diagnosis in the ELISA and Western blot analysis, (2) detection of salmonid anti-KD antibodies by an ELISA technique, (3) detection of cellular immune responses to the soluble antigen, and (4) development of immersion challenge procedures for bacterial kidney disease (BKD).

Kaattari, Stephen L.

1986-06-01T23:59:59.000Z

411

their Natural Regulators Production by PMN and PBMC in Patients with Lyme Disease  

E-Print Network (OSTI)

Recently, it has been reported that TLR2 on macrophages plays a unique role in the inflammatory response and host defense to infection with Borrelia burgdorferi (Bb) which is an etiologic agent of Lyme disease. Experimental studies show that PMNs also play an essential role in infection control by Bb. However, there is no available data about TLR2 expression on PMN in the course of Lyme disease. In the present study, TLR2 expression and production of IL-1? and IL-6 as well as their natural regulators (sIL-1RII, IL-1Ra and sIL-6R?, sgp130, resp) by PMN of peripheral blood in patients with Lyme disease were examined. For the purpose of comparison, the same activity of autologous peripheral blood mononuclear cells (PBMCs) was estimated. An effect of rhIL-15 on TLR2 and cytokine secretion was also studied. Increased TLR2 expression in unstimulated neutrophils suggests an important role of these cells in mechanism recognition of Bburgdorferiin patients with Lyme disease. The relationship between IL-1? and IL-6 as well as their regulators by unstimulated PMN and PBMC, observed in the present study, may lead to enhanced IL-6and to inhibition of IL-1?-mediated reactions in this patient group. Changes in the TLR2 expression after rhIL-15 stimulation appear to have a favorable effect on mechanism recognition of Bb. The relations between IL-6 and its regulators (sIL-6R? and sgp130) as well as between IL-1? and its regulators (IL-1Ra and sIL-1RII) after rhIL-15 stimulation may lead to enhanced IL-1?and IL-6-mediated inflammatory reactions in the course of Lyme disease. Copyright 2006 E. Jablonska and M. Marcinczyk. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Ewa Jablonska; Magdalena Marcinczyk

2005-01-01T23:59:59.000Z

412

Epidemiology and Control of Infectious Diseases of Salmonids in the Columbia River Basin, 1986 Annual Report.  

DOE Green Energy (OSTI)

The Department of Microbiology at Oregon State University with funding from the Bonneville Power Administration conducted a study relating to the epidemiology and control of three fish diseases of salmonids in the Columbia River Basin. These three diseases were ceratomyxosis caused by the myxosporidan parasite Ceratomyxa Shasta, bacterial kidney disease, the causative agent Renibacterium salmoninarum, and infectious hematopoietic necrosis, caused by a rhabdovirus. Each of these diseases is highly destructive and difficult or impossible to treat with antimicrobial agents. The geographic range of the infectious stage of C. Shasta has been extended to include the Snake River to the Oxbow and Hells Canyon Dams. These are the farthest upriver sites tested. Infections of ceratomyxosis were also initiated in the east fork of the Lewis River and in the Washougal River in Washington. Laboratory studies with this parasite failed to indicate that tubeficids are required in its life cycle. Bacterial kidney disease has been demonstrated in all life stages of salmonids: in the eggs, fry, smolts, juveniles and adults in the ocean, and in fish returning to fresh water. Monoclonal antibodies produced against R. salmoninarum demonstrated antigenic differences among isolates of the bacterium. Monoclonal antibodies also showed antigens of R. salmoninarum which are similar to those of a wide variety of gram positive and gram negative bacteria. A demonstration project at Round Butte Hatchery showed U V treatment to be an effective method for reducing the microbial population of the water supply and could reduce risks of IHNV. Tangential flow filtration was used successfully to concentrate IHNV from environmental water. At Round Butte Hatchery the carrier rate of IHNV in adults was very low and there was no subsequent mortality resulting from IHN in juveniles.

Fryer, John L.

1986-12-01T23:59:59.000Z

413

Application of Paraconsistent Artificial Neural Networks as a Method of Aid in the Diagnosis of Alzheimer Disease  

Science Conference Proceedings (OSTI)

The visual analysis of EEG has shown useful in helping the diagnosis of Alzheimer disease (AD) when the diagnosis remains uncertain, being used in some clinical protocols. However, such analysis is subject to the inherent equipment imprecision, patient ... Keywords: Alzheimer disease, Artificial neural network, Electroencephalogram, Paraconsistent logic, Pattern recognition

Helder Frederico Silva Lopes; Jair M. Abe; Renato Anghinah

2010-12-01T23:59:59.000Z

414

Nano/Microfluidics for diagnosis of infectious diseases in developing countries Won Gu Lee a,b,1  

E-Print Network (OSTI)

Nano/Microfluidics for diagnosis of infectious diseases in developing countries Won Gu Lee a,b,1 history: Received 15 June 2009 Accepted 14 September 2009 Available online 30 November 2009 Keywords: Nano/Microfluidics Infectious diseases HIV/AIDS Point-of-care Diagnostics Global health Nano/Microfluidic technologies

Demirci, Utkan

415

Outbreak of Minamata Disease (methyl mercury poisoning) in cats on northwestern Ontario Reserves  

SciTech Connect

Pathological, histochemical, and analytical studies have confirmed the presence of Minamata Disease in at least one of two cats that lived on or near Indian Reserves in Northwestern Ontario, Canada. These symptoms parallel the Japanese experience in the 1950s and raise ominous health considerations for the Indians who share their diet of fish. After being fed a diet that primarily consisted of fish from the English River, one cat developed such acute neurological symptoms as an ataxic gait, other abnormal movements, uncontrolled howling, and seizures. The total mercury analyses showed high levels in all tissues with 16.4 mg/kg in the brain comparable with symptomatic cats in Japan. A second cat that appeared normal had 6.9 mg/kg in its brain tissues, and pathological studies confirmed the presence of latent Minamata Disease.

Takeuchi, T. (Kumamoto Univ., Japan); D' Itri, F.M.; Fischer, P.V.; Annett, C.S.; Okabe, M.

1977-04-01T23:59:59.000Z

416

Outbreak of minamata disease (methyl mercury poisoning) in cats on Northwestern Ontario reserves  

SciTech Connect

Pathological, histochemical, and analytical studies have confirmed the presence of Minamata Disease in at least one of two cats that lived on or near Indian Reserves in Northwestern Ontario, Canada. These symptoms parallel the Japanese experience in the 1950s and raise ominous health considerations for the Indians who share their diet of fish. After being fed a diet that primarily consisted of fish from the English River, one cat developed such acute neurological symptoms as an ataxic gait, other abnormal movements, uncontrolled howling, and seizures. The total mercury analyses showed high levels in all tissues with 16.4 mg/kg in the brain comparable with symptomatic cats in Japan. A second cat that appeared normal had 6.9 mg/kg in its brain tissues, and pathological studies confirmed the presence of latent Minamata Disease.

Takeuchi, T. (Kumamoto Univ., Japan); D' Itri, F.M.; Fischer, P.V.; Annett, C.S.; Okabe, M.

1977-04-01T23:59:59.000Z

417

Interactions of phagocytes with the Lyme disease spirochete: role of the Fc receptor  

Science Conference Proceedings (OSTI)

The phagocytic capacity of murine and human mononuclear and polymorphonuclear phagocytes (including peripheral blood monocytes and neutrophils), rabbit and murine peritoneal exudate cells, and the murine macrophage cell line P388D1 against the Lyme disease spirochete was studied. All of these cells were capable of phagocytosing the spirochete; phagocytosis was measured by the uptake of radiolabeled spirochetes, the appearance of immunofluorescent bodies in phagocytic cells, and electron microscopy. Both opsonized and nonopsonized organisms were phagocytosed. The uptake of opsonized organisms by neutrophils was blocked by a monoclonal antibody specific for the Fc receptor and by immune complexes; these findings suggested that most phagocytosis is mediated by the Fc receptor. Similarly, the uptake of opsonized organisms by human monocytes was inhibited by human monomeric IgG1 and by immune complexes. These results illustrate the role of immune phagocytosis of spirochetes in host defense against Lyme disease.

Benach, J.L.; Fleit, H.B.; Habicht, G.S.; Coleman, J.L.; Bosler, E.M.; Lane, B.P.

1984-10-01T23:59:59.000Z

418

Epidemiology and Control of Infectious Diseases of Salmonids in the Columbia River Basin, 1984 Annual Report.  

DOE Green Energy (OSTI)

The Department of Microbiology at Oregon State University with funding from the Bonneville Power Administration has conducted a study since 1983 relating to the epidemiology and control of three diseases of salmonids in the Columbia River Basin. These diseases are ceratomyxosis, caused by the protozoan parasite Ceratomyxa Shasta, bacterial kidney disease, the etiological agent of which is Renibacterium salmoninarum and infectious hematopoietic necrosis which is caused by a rhabdovirus. Each of these diseases is difficult or impossible to treat with antimicrobial agents. The presence of the infectious stage of C. shasta was again detected at Little Goose Dam on the Snake River. The prevalence of ceratomyxosis increased from 1.1% in 1984 to 10% in 1985. None of the susceptible rainbow trout exposed in the Yakima and Umatilla Rivers died of this disease. Ceratomyxosis in resistant chinook salmon smolts seined from the Columbia River just above the estuary seems dependent on whether or not they are held after capture in fresh or salt water. In fresh water the disease incidence ranged from 7--19%, whereas in salt water it ranged from 0--3%. These results which suggest that recovery from ceratomyxosis may occur after the smolts enter salt water are different from those obtained with susceptible Alsea steelhead trout where experimental groups in salt water have died at the same rate as those in fresh water. Comparing data from groups of Columbia River chinook smolts held after capture in either fresh or salt water, R. salmoninarum is a much more effective pathogen in the salt water environment. After four years of sampling smolts in the open ocean, numbers of this microorganism sufficient to cause death have been detected in chinook (7%) and, coho salmon (2%) and steelhead trout (1%). Results from three years of sampling have consistently indicated that additional fish infected with R. salmoninarum will be detected if egg washings are included in the procedures for monitoring bacterial kidney disease in adults. Antigenic differences among strains of R. salmoninarum and common antigens present on both R. salmoninarum and other Gram positive bacteria have been demonstrated for the first time using monoclonal antibodies. All of the monoclonal antibodies belong to the murine IgGl, IgG3 or TgG2a class and subclass. Field studies at Round Butte Hatchery with the molecular filtration apparatus detected IHNV in effluent water from the adult holding pond and in water from a tank containing steelhead trout fry infected with IHN disease. The concentrations of IHNV detected in these samples suggested that in the order of 10{sup 10} virions are being released each day into the Deschutes River at the peak of steelhead trout spawning at Round Butte Hatchery. Isolation of IHNV from dead eggs suggested that virus replication during incubation may be a possible cause of egg mortality. Two possible reasons for inconsistencies in the data from the IHNV transmission studies at Round Butte Hatchery are: (1) UV treatment does not completely sterilize the water and (2) vertical transmission occurs but under, as yet, undescribed conditions. Constant IHNV production over a prolonged period has been recorded in unfiltered ovarian fluid samples. Filtration eliminates this virus production. These observations suggest that cellular components in ovarian fluid are responsible for producing the delayed appearance of IHNV after storage at 4 C for 8 to 16 days.

Fryer, John L.

1985-11-01T23:59:59.000Z

419

Application of Empirical Mode Decomposition (EMD) on DaTSCAN SPECT images to explore Parkinson Disease  

Science Conference Proceedings (OSTI)

Parkinsonism is the second most common neurodegenerative disorder. It includes several pathologies with similar symptoms, what makes the diagnosis really difficult. I-ioflupane allows to obtain in vivo images of the brain that can be used to assist the ... Keywords: Computer Aided Diagnosis (CAD), DaTSCAN, Empirical Mode Decomposition (EMD), Independent Component Analysis (ICA), Parkinson Disease (PD), Parkinsonian Syndrome (PS), Principal Component Analysis (PCA), Support Vector Machines (SVM)

A. Rojas; J. M. GRriz; J. RamRez; I. A. IllN; F. J. MartNez-Murcia; A. Ortiz; M. GMez RO; M. Moreno-Caballero

2013-06-01T23:59:59.000Z

420

Follow-up Review of the Hanford Site Chronic Beryllium Disease Prevention Program, February 2013  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Independent Oversight Independent Oversight Follow-up Review of the Hanford Site Chronic Beryllium Disease Prevention Program February 2013 Office of Safety and Emergency Management Evaluations Office of Enforcement and Oversight Office of Health, Safety and Security U.S. Department of Energy Table of Contents 1.0 Purpose................................................................................................................................... 1 2.0 Background ............................................................................................................................ 1 3.0 Scope...................................................................................................................................... 1 4.0 Results.................................................................................................................................... 2

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

A standard dose of radiation for microscopic disease is not appropriate  

SciTech Connect

Elective irradiation of sites of potential occult tumor spread is often part of a patient's radiation therapy program. The required radiation dose (D) depends on the probability that occult disease exists (P(occ)), the number of sites at risk (A), the number of tumor clonogens present (Ni), their radiation sensitivity, and the desired control rate. An exponential model of cell survival is used to quantify the importance of these factors. Control Probability = (1 - Pocc x (1 - e-Ni x (SF2)D/2))A; SF2 = surviving fraction after 2 Gy. Implications for clinical radiation therapy include: 1. Since the number of clonogens in an occult site may vary from 10 degrees to 10(8), Ni is the major determinant of the required dose. The intrinsic radiation sensitivity of the clonogens (SF2) is also extremely important in determining the dose. Other factors are less influential since they vary less. 2. The variability of Ni (8 logs) is larger than the variation in cell number seen with gross disease (1 cm3 versus 1000 cm3, 3 logs). When Ni approximately 10(8), the required dose approaches that needed for small volume gross disease (10(9) cells, 1 cm3). 3. The dose prescribed to elective sites should reflect the risk of occult disease based on the primary tumor site, stage, and grade. 4. Regions where clinicoradiologic evaluation is difficult (e.g., pelvis and obese neck) require higher doses because macroscopic tumor deposits may exist. 5. Relatively low doses (10 to 30 Gy) are often thought to be inadequate for microscopic tumor. However, similar doses have been reported to sterilize microscopic tumor in ovarian, rectal, bladder, breast, and head and neck carcinomas. Relatively low doses should not be discounted since they may be useful in select cases when normal tissue tolerances and/or previous irradiation treatment limit the radiation dose.

Marks, L.B. (Duke Univ. Medical Center, Durham, NC (USA))

1990-12-15T23:59:59.000Z

422

In silico approach to discover multi-target-directed ligands for the treatment of Alzheimer's disease  

Science Conference Proceedings (OSTI)

Multi-target directed (MTD) drugs have been found to be very effective in controlling neurodegenerative diseases. We have developed an in silico strategy to screen molecules for both AChE and BACE-1 enzyme dual inhibition. Pharmacophore model ... Keywords: ?-secretase, in silico drug design, ADMET screening, GOLD, GOLD score, HIPHOP, Lipinski's rule, acetylcholinesterase, blood-brain barrier, cholinesterase inhibitors, discovery studio, docking, pharmacophore modeling, protein data bank, virtual screening

Ankit Tyagi; Shikhar Gupta; C. Gopi Mohan

2010-02-01T23:59:59.000Z

423

Epithelioid Angiosarcoma With Metastatic Disease After Endovascular Therapy of Abdominal Aortic Aneurysm  

Science Conference Proceedings (OSTI)

Malignancies of the aortic wall represent a rare condition, and only a few reports have covered cases of sarcomas arising at the site of a prosthesis made of Dacron. A coincidence with endovascular repair has only been reported in one case to date. We report a patient with epithelioid angiosarcoma and metastatic disease, which was found in an aneurysmal sac after endovascular aortic repair for abdominal aortic aneurysm.

Schmehl, Joerg, E-mail: joerg.schmehl@med.uni-tuebingen.de [University Hospital of Tuebingen, Department of Diagnostic and Interventional Radiology (Germany); Scharpf, Marcus [University Hospital of Tuebingen, Institute of Pathology and Neuropathology (Germany); Brechtel, Klaus [University Hospital of Tuebingen, Department of Diagnostic and Interventional Radiology (Germany); Kalender, Guenay [University Hospital of Tuebingen, Department of Thoracic and Cardiovascular Surgery (Germany); Heller, Stephan; Claussen, Claus D. [University Hospital of Tuebingen, Department of Diagnostic and Interventional Radiology (Germany); Lescan, Mario [University Hospital of Tuebingen, Department of Thoracic and Cardiovascular Surgery (Germany)

2012-02-15T23:59:59.000Z

424

Spatio-temporal relationships between feral hogs and cattle with implicatons for disease transmission  

E-Print Network (OSTI)

It is widely recognized that livestock industries are vulnerable to intentional or accidental introductions of Foreign Animal Diseases (FADs). Combating disease is difficult because of unknown wildlife-livestock interactions. Feral hogs (Sus scrofa) could harbor and shed disease in areas used by domestic livestock such as cattle (Bos taurus). Extent of risk logically depends on spatio-temporal interactions between species. I used Global Positioning System (GPS) collars on cattle and hogs in combination with a Geographic Information Systems (GIS) for detailed analysis on movement patterns of these 2 species on a ranch in southwestern Texas, USA. Motion-triggered video recorders were also utilized to determine interspecific activity patterns. I tested hypotheses that spatio-temporal distributions of domestic cattle and feral hogs on rangeland overlap and that interspecific contact occurs. If these posits are true, it is possible that introduced pathogens like foot-and-mouth disease (FMD) could be transmitted from feral hogs to cattle. Using a rate of 1 GPS fix/15 min (96 fixes/day), I found that spatial distribution of individual hogs and cattle overlapped on both the 95% and 50% kernel area use among 4 seasons. Both cows and feral hogs used Clay Flat, Clay Loam, and Rolling Hardland more so than other range sites. During Summer 2004, riparian zones were the most used feature, identified at 14% (2,760/19,365) of cattle and 70% (445/632) of hog fixes. Other than brush strips, cattle and feral hogs primarily interacted at riparian zones, fencelines, and roads. There were no direct interspecific contacts evident from GPS data, but 3 cases were recorded from video data. Indirect interspecific contacts that may be sufficient for disease transmission occurred much more frequently (GPS = 3.35 indirect contacts/day, video = cows follow hogs: 0.69 indirect contacts/day and hogs follow cows: 0.54 indirect contacts/day). Research results suggested that both species often travel along the same roads and fencelines to water and food sources, especially during extreme heat and low-precipitation conditions. This research provides basic information needed to improve models for management of FAD outbreaks in the U.S., based on specific knowledge of landscape usage and movement patterns of feral hogs and cattle.

Deck, Aubrey Lynn

2003-05-01T23:59:59.000Z

425

AN EAR FOR YOUR QUOTES PATENT CITATIONS AND THE SIZE OF PATENTED INVENTIONS, EVIDENCE FROM HYBRID CORN  

E-Print Network (OSTI)

This paper links applications for utility patents between 1985 and 2005 with field trial data on improvements in yields to examine whether citations are a good measure for the size of the inventive step, measured as improvements in yield. These data indicate that a large and robust correlation between citations and the size of improvements. In the most conservative estimates, a 10 percent increase in yields is associated with 1.7 additional citations, implying a 24 percent increase. A small number of highly cited patents appear to be cited mostly to establish the patentability of corn hybrids. Estimates that exclude these patents indicate that a 10 percent in yields is associated with 1.2 additional citations, implying a 34 percent increase. Analyses of claims and renewal data as alternative measures of patent value suggest that citations are in fact the most informative measure for the size of patented inventions.

unknown authors

2012-01-01T23:59:59.000Z

426

Daylight in faade renewal : using new metrics to inform the retrofitting of aging modern-ear faade types  

E-Print Network (OSTI)

New methods for quantifying daylight are increasingly accessible to designers and planners. While these methods have enabled new building facades to better balance the admission of daylight with the maintenance of thermal ...

Rice, Edward Oren

2006-01-01T23:59:59.000Z

427

Dietary Fats and Risk of Chronic DiseaseChapter 19 Functionalities and Production with Biocatalysis of Two Highly Polyunsaturated Phospholipids  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 19 Functionalities and Production with Biocatalysis of Two Highly Polyunsaturated Phospholipids Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press ...

428

Palm Oil: Production, Processing, Uses, and CharacterizationChapter 6 Effect of Pests and Diseases on Oil Palm Yield  

Science Conference Proceedings (OSTI)

Palm Oil: Production, Processing, Uses, and Characterization Chapter 6 Effect of Pests and Diseases on Oil Palm Yield Food Science Health Nutrition Processing eChapters Food Science & Technology Health - Nutrition - Biochemistry Process

429

Flow cytometry quantitation of dopamine receptor D2 loss as a sensitive measure of Huntington's Disease progression in mouse neurons  

E-Print Network (OSTI)

Mouse models of Huntington's Disease (HD) are often used for testing potential therapeutic compounds. These experiments require substantial investments in time and resources, and have yet to produce any intervention that ...

Crook, Zachary R. (Zachary Ryan)

2013-01-01T23:59:59.000Z

430

Fatty Acids in Health Promotion and Disease CausationChapter 19 Linoleic Acids and Cancer Cell Functions  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 19 Linoleic Acids and Cancer Cell Functions Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf of Chapt

431

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network (OSTI)

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

432

Dietary Fats and Risk of Chronic DiseaseChapter 16 Health Benefits of Dietary Diacylglycerol In Practical Use  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 16 Health Benefits of Dietary Diacylglycerol In Practical Use Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf of

433

Flaxseed in Human Nutrition, 2nd EditionChapter 12 a-Linolenic Acid and Heart Disease  

Science Conference Proceedings (OSTI)

Flaxseed in Human Nutrition, 2nd Edition Chapter 12 a-Linolenic Acid and Heart Disease Food Science Health Nutrition Biochemistry eChapters Food Science & Technology Health - Nutrition - Biochemistry Press Downloadable

434

Flaxseed in Human Nutrition, 2nd EditionChapter 16 Flaxseed and Flaxseed Products in Kidney Disease  

Science Conference Proceedings (OSTI)

Flaxseed in Human Nutrition, 2nd Edition Chapter 16 Flaxseed and Flaxseed Products in Kidney Disease Food Science Health Nutrition Biochemistry eChapters Food Science & Technology Health - Nutrition - Biochemistry Press ...

435

Dietary Fats and Risk of Chronic DiseaseChapter 1 Seeking Better Dietary Fats for Human Health  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 1 Seeking Better Dietary Fats for Human Health Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf of Chapter 1 Seeki

436

Changes in Gas Bubble Disease Signs for Migrating Juvenile Salmonids Experimentally Exposed to Supersaturated Gasses, 1996-1997 Progress Report.  

DOE Green Energy (OSTI)

This study was designed to answer the question of whether gas bubble disease (GBD) signs change as a result of the hydrostatic conditions juvenile salmonids encounter when they enter the turbine intake of hydroelectric projects during their downstream migration.

Absolon, Randall F.

1999-03-01T23:59:59.000Z

437

Flaxseed in Human Nutrition, 2nd EditionChapter 15 Flaxseed, Fiber and Coronary Heart Disease: Clinical Studies  

Science Conference Proceedings (OSTI)

Flaxseed in Human Nutrition, 2nd Edition Chapter 15 Flaxseed, Fiber and Coronary Heart Disease: Clinical Studies Food Science Health Nutrition Biochemistry eChapters Food Science & Technology Health - Nutrition - Biochemistry Press

438

Fatty Acids in Health Promotion and Disease CausationChapter 11 Trans Fatty Acids and Cardiometabolic Syndrome  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 11 Trans Fatty Acids and Cardiometabolic Syndrome Health Nutrition Biochemistry Trans eChapters Health - Nutrition - Biochemistry Press Downloadable pdf ...

439

Fatty Acids in Health Promotion and Disease CausationChapter 27 Polyunsaturated Fatty Acids: Effects on Steroid-hormone Biosynthesis  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 27 Polyunsaturated Fatty Acids: Effects on Steroid-hormone Biosynthesis Health eChapters Health - Nutrition - Biochemistry Press Downloadable pdf of Ch

440

Fatty Acids in Health Promotion and Disease CausationChapter 31 Food Sources and Intakes of Omega-3 Fatty Acids  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 31 Food Sources and Intakes of Omega-3 Fatty Acids Health Nutrition Biochemistry Omega 3 eChapters Health - Nutrition - Biochemistry Press Downloadable pdf ...

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441

Fatty Acids in Health Promotion and Disease CausationChapter 21 Fatty Acids and Lipids in Neurobiology: A Brief Overview  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 21 Fatty Acids and Lipids in Neurobiology: A Brief Overview Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf ...

442

Fatty Acids in Health Promotion and Disease CausationChapter 17 Fatty Acid Metabolism and Peroxisome Proliferator-activated Receptors  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 17 Fatty Acid Metabolism and Peroxisome Proliferator-activated Receptors Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downl

443

Fatty Acids in Health Promotion and Disease CausationChapter 10 Fatty Acids in Nuts: Cardiometabolic Health Benefits  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 10 Fatty Acids in Nuts: Cardiometabolic Health Benefits Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf ...

444

Fatty Acids in Health Promotion and Disease CausationChapter 4 Fatty Acids and Cardiac Ischemia-reperfusion Injury  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 4 Fatty Acids and Cardiac Ischemia-reperfusion Injury Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf ...

445

Fatty Acids in Health Promotion and Disease CausationChapter 1 Trans and Other Fatty Acids: Effects on Endothelial Functions  

Science Conference Proceedings (OSTI)

Fatty Acids in Health Promotion and Disease Causation Chapter 1 Trans and Other Fatty Acids: Effects on Endothelial Functions Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable p

446

Dietary Fats and Risk of Chronic DiseaseChapter 2 Omega-3 Polyunsaturated Fatty Acids And Cancer Cachexia  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 2 Omega-3 Polyunsaturated Fatty Acids And Cancer Cachexia Health Nutrition Biochemistry Omega 3 eChapters Health - Nutrition - Biochemistry Press Downloadable pdf ...

447

Epidemiology and Control of Infectious Diseases of Salmonids in the Columbia River Basin, 1987 Annual Report.  

DOE Green Energy (OSTI)

The Department of Microbiology at Oregon State University with funding from the Bonneville Power Administration has been conducting a study concerning the epidemiology and control of three fish pathogens which cause major disease problems in salmonids of the Columbia River basin. The pathogens studied include Cera to myxa Shasta, the myxosporean parasite which causes ceratomyxosis; Renibacterium salmoninarum, the bacterium which is the etiological agent of bacterial kidney disease; and the rhabdovirus which causes infectious hematopoietic necrosis (IHN). During this project, the host and geographic range of C. Shasta have been more precisely determined and the known geographic range has been significantly expanded. The effects of the parasite on fish migrating through the Columbia River and on their introduction into salt water have been examined. Similar studies have been conducted with R. salmoninarum and it has been shown that bacterial kidney disease occurs at all life stages of salmonids and is responsible for mortality in both fresh and salt water. It has also been demonstrated that different isolates of R. salmoninarum have different antigenic composition. Results of demonstration projects designed to control IHN by using UV treated water for early rearing of salmonid fry were equivocal. The scope of the project was considerably narrowed and focused during the past two years The project has concentrated on a study concerning the biology of C. Shasta and the identification of potential chemotherapeutants for control of bacterial kidney disease. The emphasis of work on C. Shasta has been its pathogenesis. This aspect of the parasite has been investigated using histopathologic and immunologic methodology. Mode of transmission, the nature of the infectious stage, and potential intermediate hosts of the parasite have also been areas of active research. Classes of chemotherapeutants with the highest potential for efficacy against R. salmoninarum have been identified through literature searches and consultation with pharmacologists. Experimental drugs have been requested and received from several pharmaceutical manufacturers. The in vitro sensitivity of R. salmoninarum and other selected fish pathogens to more than 100 antimicrobial compounds has been tested. The project is related to measure 704(h)(2)(d) of the Columbia River Basin Fish and Wildlife Program. The results will contribute to fish health which will directly contribute to the protection of fish.

Fryer, John L.

1989-01-01T23:59:59.000Z

448

Two-transcript gene expression classifiers in the diagnosis and prognosis of human diseases  

E-Print Network (OSTI)

ral ssBioMed CentBMC Genomics Open AcceResearch article Two-transcript gene expression classifiers in the diagnosis and prognosis of human diseases Lucas B Edelman1,2,6, Giuseppe Toia1,2, Donald Geman4, Wei Zhang5 and Nathan D Price*1,2,3 Address... : 1Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA, 2Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA, 3Department of Chemical and Biomolecular...

Edelman, Lucas B; Toia, Giuseppe; Geman, Donald; Zhang, Wei; Price, Nathan D

2009-12-05T23:59:59.000Z

449

A Hybrid Sensitivity Analysis Approach for Agent-based Disease Spread Models  

Science Conference Proceedings (OSTI)

Agent-based models (ABM) have been widely deployed in different fields for studying the collective behavior of large numbers of interacting agents. Of particular interest lately is the application of agent-based and hybrid models to epidemiology, specifically Agent-based Disease Spread Models (ABDSM). Validation (one aspect of the means to achieve dependability) of ABDSM simulation models is extremely important. It ensures that the right model has been built and lends confidence to the use of that model to inform critical decisions. In this report, we describe our preliminary efforts in ABDSM validation by using hybrid model fusion technology.

Pullum, Laura L [ORNL; Cui, Xiaohui [New York Institute of Technology (NYIT)

2012-01-01T23:59:59.000Z

450

Risk of Developing Cardiovascular Disease After Involved Node Radiotherapy Versus Mantle Field for Hodgkin Lymphoma  

SciTech Connect

Purpose: Hodgkin lymphoma (HL) survivors are known to have increased cardiac mortality and morbidity. The risk of developing cardiovascular disease after involved node radiotherapy (INRT) is currently unresolved, inasmuch as present clinical data are derived from patients treated with the outdated mantle field (MF) technique. Methods and Materials: We included all adolescents and young adults with supradiaphragmatic, clinical Stage I-II HL treated at our institution from 2006 to 2010 (29 patients). All patients were treated with chemotherapy and INRT to 30 to 36 Gy. We then simulated a MF plan for each patient with a prescribed dose of 36 Gy. A logistic dose-response curve for the 25-year absolute excess risk of cardiovascular disease was derived and applied to each patient using the individual dose-volume histograms. Results: The mean doses to the heart, four heart valves, and coronary arteries were significantly lower for INRT than for MF treatment. However, the range in doses with INRT treatment was substantial, and for a subgroup of patients, with lymphoma below the fourth thoracic vertebrae, we estimated a 25-year absolute excess risk of any cardiac event of as much as 5.1%. Conclusions: Our study demonstrates a potential for individualizing treatment by selecting the patients for whom INRT provides sufficient cardiac protection for current technology; and a subgroup of patients, who still receive high cardiac doses, who would benefit from more advanced radiation technique.

Maraldo, Maja V., E-mail: dra.maraldo@gmail.com [Department of Radiation Oncology, Rigshospitalet, Copenhagen (Denmark); Brodin, Nils Patrik; Vogelius, Ivan R.; Aznar, Marianne C.; Munck af Rosenschoeld, Per; Petersen, Peter M. [Department of Radiation Oncology, Rigshospitalet, Copenhagen (Denmark); Specht, Lena [Department of Radiation Oncology, Rigshospitalet, Copenhagen (Denmark); Faculty of Health Sciences, University of Copenhagen, Copenhagen (Denmark)

2012-07-15T23:59:59.000Z

451

0 A Data-Adaptive Sum Test for Disease Association with Multiple Common or Rare Variants  

E-Print Network (OSTI)

Given typically weak associations between complex diseases and common variants, and emerging approaches to genotyping rare variants (e.g. by next-generation resequencing), there is an urgent demand to develop powerful association tests that are applicable to detecting disease association with both common and rare variants. In this article we develop such a test. It is based on data-adaptive modifications to a so-called Sum test originally proposed for common variants, which aims to strike a balance in utilizing information in multiple markers in linkage disequilibrium (LD) while reducing the cost of large degrees of freedom (DF) or of multiple testing adjustment. When applied to multiple common or rare variants in a candidate region, the proposed test is easy to use with DF=1 and without need for multiple testing adjustment. We show that the proposed test has high power across a wide range of scenarios with either common or rare variants, or both. In particular, under some situations the proposed test performs better than several commonly used methods. Key words: Genome-wide association study; GWAS; logistic regression; multi-marker analysis; SNP 1

Fang Han; Wei Pan

2009-01-01T23:59:59.000Z

452

Resected Pancreatic Neuroendocrine Tumors: Patterns of Failure and Disease-Related Outcomes With or Without Radiotherapy  

SciTech Connect

Purpose: Pancreatic neuroendocrine tumors (NET) are rare and have better disease-related outcomes compared with pancreatic adenocarcinoma. Surgical resection remains the standard of care, although many patients present with locally advanced or metastatic disease. Little is known regarding the use of radiotherapy in the prevention of local recurrence after resection. To better define the role of radiotherapy, we performed an analysis of resected patients at our institution. Methods: Between 1994 and 2009, 33 patients with NET of the pancreatic head and neck underwent treatment with curative intent at Duke University Medical Center. Sixteen patients were treated with surgical resection alone while an additional 17 underwent resection with adjuvant or neoadjuvant radiation therapy, usually with concurrent fluoropyrimidine-based chemotherapy (CMT). Median radiation dose was 50.4 Gy and median follow-up 28 months. Results: Thirteen patients (39%) experienced treatment failure. Eleven of the initial failures were distant, one was local only and one was local and distant. Two-year overall survival was 77% for all patients. Two-year local control for all patients was 87%: 85% for the CMT group and 90% for the surgery alone group (p = 0.38). Two-year distant metastasis-free survival was 56% for all patients: 46% and 69% for the CMT and surgery patients, respectively (p = 0.10). Conclusions: The primary mode of failure is distant which often results in mortality, with local failure occurring much less commonly. The role of radiotherapy in the adjuvant management of NET remains unclear.

Zagar, Timothy M. [Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC (United States); White, Rebekah R. [Department of Surgery, Duke University Medical Center, Durham, NC (United States); Willett, Christopher G. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Tyler, Douglas S. [Department of Surgery, Duke University Medical Center, Durham, NC (United States); Papavassiliou, Paulie [Department of Pathology, Duke University Medical Center, Durham, NC (United States); Papalezova, Katia T. [Department of Surgery, Duke University Medical Center, Durham, NC (United States); Guy, Cynthia D. [Department of Pathology, Duke University Medical Center, Durham, NC (United States); Broadwater, Gloria [Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC (United States); Clough, Robert W. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Czito, Brian G., E-mail: czito001@mc.duke.edu [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)

2012-07-15T23:59:59.000Z

453

Biodiversity of Borrelia burgdorferi Strains in Tissues of Lyme Disease Patients  

E-Print Network (OSTI)

Plant and animal biodiversity are essential to ecosystem health and can provide benefits to humans ranging from aesthetics to maintaining air quality. Although the importance of biodiversity to ecology and conservation biology is obvious, such measures have not been applied to strains of an invasive bacterium found in human tissues during infection. In this study, we compared the strain biodiversity of Borrelia burgdorferi found in tick populations with that found in skin, blood, synovial fluid or cerebrospinal fluid of Lyme disease patients. The biodiversity of B. burgdorferi strains is significantly greater in tick populations than in the skin of patients with erythema migrans. In turn, strains from skin are significantly more diverse than strains at any of the disseminated sites. The cerebrospinal fluid of patients with neurologic Lyme disease harbored the least pathogen biodiversity. These results suggest that human tissues act as niches that can allow entry to or maintain only a subset of the total pathogen population. These data help to explain prior clinical observations on the natural history of B. burgdorferi infection and raise several questions that may help to direct future research to better understand the pathogenesis of this infection.

Dustin Brisson; Nilofer Baxamusa; Ira Schwartz; Gary P. Wormser

2011-01-01T23:59:59.000Z

454

Proteomic Analysis of Lyme Disease: Global Protein Comparison of Three Strains of Borrelia burgdorferi  

SciTech Connect

The Borrelia burgdorferi spirochete is the causative agent of Lyme disease, the most common tick-borne disease in the United States. It has been studied extensively to help understand its pathogenicity of infection and how it can persist in different mammalian hosts. We report the proteomic analysis of the archetype B. burgdorferi B31 strain and two other strains (ND40, and JD-1) having different Borrelia pathotypes using strong cation exchange fractionation of proteolytic peptides followed by high-resolution, reversed phase capillary liquid chromatography coupled with ion trap tandem mass spectrometric (LC-MS/MS) analysis. Protein identification was facilitated by the availability of the complete B31 genome sequence. A total of 665 Borrelia proteins were identified representing {approx}38% coverage of the theoretical B31 proteome. A significant overlap was observed between the identified proteins in direct comparisons between any two strains (>72%), but distinct differences were observed among identified hypothetical and outer membrane proteins of the three strains. Such a concurrent proteomic overview of three Borrelia strains based upon only the B31 genome sequence is shown to provide significant insights into the presence or absence of specific proteins and a broad overall comparison among strains.

Jacobs, Jon M.; Yang, Xiaohua; Luft, Benjamin J.; Dunn, John J.; Camp, David G.; Smith, Richard D.

2005-04-01T23:59:59.000Z

455

Neonatal chronic lung disease in extremely immature baboons. Am J Respir Crit Care Med  

E-Print Network (OSTI)

A borderline viability model of bronchopulmonary dysplasia (BPD)/chronic lung disease of infancy (CLD) with pathophysiologic parameters consistent with those in extremely immature humans with BPD/CLD is described. After prenatal steroid treatment of pregnant dams, 12 premature baboons were delivered by cesarean-section at 125 d (term gestation, 185 d), treated with exogenous surfactant, and maintained on appropriate oxygen and positive pressure ventilation for at least 1 to 2 mo. In spite of appropriate oxygenation (median FI O2 at 28 d ? 0.32; range, 0.21 to 0.50) and ventilatory strategies to prevent volutrauma, the baboons exhibited pulmonary pathologic lesions known to occur in extremely immature humans of less than 1,000 g: alveolar hypoplasia, variable saccular wall fibrosis, and minimal, if any, airway disease. The CLD baboon lungs showed significantly decreased alveolization and internal surface area measurements when compared with term and term ? 2-mo air-breathing controls. A decrease in capillary vasculature was evident by PECAM staining, accompanied by dysmorphic changes. Significant elevations of TNF-?, IL-6, IL-8 levels, but not of IL-1 ? and IL-10, in tracheal aspirate fluids were present at various times during the period of ventilatory support, supporting a role for mediator-induced autoinflammation. IL-8 levels were elevated in necropsy lavages of animals with significant lung infection. This model demonstrates that impaired alveolization

Jacqueline J. Coalson; Vicki T. Winter; Theresa Siler-khodr; Bradley A. Yoder

1999-01-01T23:59:59.000Z

456

Percutaneous Image-Guided Aspiration and Sclerosis of Adventitial Cystic Disease of the Femoral Vein  

Science Conference Proceedings (OSTI)

Adventitial cystic disease (ACD), also known as cystic mucoid or myxomatous degeneration, is a rare vascular disease mainly seen in arteries. Seventeen cases have been reported in the world literature. We report the first known case of ACD successfully treated with percutaneous image-guided ethanol sclerosis. Computed tomography showed a cystic mass adherent to the wall of the common femoral vein. An ultrasound examination revealed a deep venous thrombosis of the leg, secondary to extrinsic compression of the common femoral vein. Three years prior to our procedure, the cyst was aspirated, which partially relieved the patient's symptoms. Over the following 3 years the patient's symptoms worsened and a 10-cm discrepancy in thigh size developed, in addition to the deep venous thrombosis associated with lower-extremity edema. Using ultrasound guidance and fluoroscopic control, the cyst was drained and then sclerosed with absolute ethanol. The patient's symptoms and leg swelling resolved completely within several weeks. Follow-up physical examination and duplex ultrasound 6 months following sclerosis demonstrated resolution of the symptoms and elimination of the extrinsic compression effect of the ACD on the common femoral vein.

Johnson, Jason M. [University of Vermont College of Medicine, Fletcher Allen Health Care, Section of Interventional Radiology, Department of Radiology (United States); Kiankhooy, Armin; Bertges, Daniel J. [Fletcher Allen Health Care, Section of Vascular Surgery, Department of Surgery (United States); Morris, Christopher S., E-mail: Christopher.Morris@vtmednet.or [University of Vermont College of Medicine, Fletcher Allen Health Care, Section of Interventional Radiology, Department of Radiology (United States)

2009-07-15T23:59:59.000Z

457

MODELING HOST-PATHOGEN INTERACTIONS: COMPUTATIONAL BIOLOGY AND BIOINFORMATICS FOR INFECTIOUS DISEASE RESEARCH (Session introduction)  

SciTech Connect

Pathogenic infections are a major cause of both human disease and loss of crop yields and animal stocks and thus cause immense damage to the worldwide economy. The significance of infectious diseases is expected to increase in an ever more connected warming world, in which new viral, bacterial and fungal pathogens can find novel hosts and ecologic niches. At the same time, the complex and sophisticated mechanisms by which diverse pathogenic agents evade defense mechanisms and subvert their hosts networks to suit their lifestyle needs is still very incompletely understood especially from a systems perspective [1]. Thus, understanding host-pathogen interactions is both an important and a scientifically fascinating topic. Recently, technology has offered the opportunity to investigate host-pathogen interactions on a level of detail and scope that offers immense computational and analytical possibilities. Genome sequencing was pioneered on some of these pathogens, and the number of strains and variants of pathogens sequenced to date vastly outnumbers the number of host genomes available. At the same time, for both plant and human hosts more and more data on population level genomic variation becomes available and offers a rich field for analysis into the genetic interactions between host and pathogen.

McDermott, Jason E.; Braun, Pascal; Bonneau, Richard A.; Hyduke, Daniel R.

2011-12-01T23:59:59.000Z

458

Essays on Modeling the Economic Impacts of a Foreign Animal Disease on the United States Agricultural Sector  

E-Print Network (OSTI)

Foreign animal disease can cause serious damage to the United States (US) agricultural sector and foot-and-mouth disease (FMD), in particular, poses a serious threat. FMD causes death and reduced fecundity in infected animals, as well as significant economic consequences. FMD damages can likely be reduced through implementing pre-planned response strategies. Empirical studies have evaluated the economic consequences of alternative strategies, but typically employ simplified models. This dissertation seeks to improve US preparedness for avoiding and/or responding to an animal disease outbreak by addressing three issues related to strategy assessment in the context of FMD: integrated multi region economic and epidemic evaluation, inclusion of risk, and information uncertainty. An integrated economic/epidemic evaluation is done to examine the impact of various control strategies. This is done by combining a stochastic, spatial FMD simulation model with a national level, regionally disaggregated agricultural sector mathematical programming economic model. In the analysis, strategies are examined in the context of California's dairy industry. Alternative vaccination, disease detection and movement restriction strategies are considered as are trade restrictions. The results reported include epidemic impacts, national economic impacts, prices, regional producer impacts, and disease control costs under the alternative strategies. Results suggest that, including trade restrictions, the median national loss from the disease outbreak is as much as $17 billion when feed can enter the movement restriction zone. Early detection reduces the median loss and the standard deviation of losses. Vaccination does not reduce the median disease loss, but does have a smaller standard deviation of loss which would indicate it is a risk reducing strategy. Risk in foreign animal disease outbreaks is present from several sources; however, studies comparing alternative control strategies assume risk neutrality. In reality, there will be a desire to minimize the national loss as well as minimize the chance of an extreme outcome from the disease (i.e. risk aversion). We perform analysis on FMD control strategies using breakeven risk aversion coefficients in the context of an outbreak in the Texas High Plains. Results suggest that vaccination while not reducing average losses is a risk reducing strategy. Another issue related to risk and uncertainty is the response of consumers and domestic markets to the presence of FMD. Using a highly publicized possible FMD outbreak in Kansas that did not turn out to be true, we examine the role of information uncertainty in futures market response. Results suggest that livestock futures markets respond to adverse information even when that information is untrue. Furthermore, the existence of herding behavior and potential for momentum trading exaggerate the impact of information uncertainty related to animal disease.

Hagerman, Amy Deann

2009-12-01T23:59:59.000Z

459

Development of a Vaccine for Bacterial Kidney Disease in Salmon, 1988 Final Report.  

DOE Green Energy (OSTI)

Bacterial kidney disease of salmonids is a very complex disease which appears to exploit a variety of pathogenic mechanisms. An understanding of these mechanisms is essential to the development of efficacious vaccines. It has become well established from the studies published .in this report and those of others that soluble antigens which are secreted by Renibacterium salmoninarum have toxigenic potential. If they are found to be responsible for mortality, the development of toxoid(s) could be paramount to the production of a vaccine. One must, however, be circumspect in producing a vaccine. A thorough knowledge, not only of the pathogen, but also of the immune system of the host is an absolute requirement. This becomes of particular importance when dealing with fish diseases, since the field of fish immunology is still within its infancy. This lack of knowledge is particularly felt when the induction of a prophylactic immune response concomitantly leads to pathological side effects which may be as destructive as the original infection. Indeed, it appears that some aspects of BKD may be due to the induction of hypersensitivity reactions. If such immunopathologies are expressed, it is prudent to thoroughly evaluate the nature of the immunoprophylaxis to insure that these harmful sequelae do not occur. Evaluation of a variety of antigens, adjuvants, immune responses, and survival data leads us to recommend that attempts at prophylaxis against BKD should center upon the elicitation of cellular immunity utilizing preparations of Mycobacterium chelonii. The choice of this species of mycobacteria was made because of its effectiveness, ease of maintenance and production, and the lack of need for its propagation within containment facilities. These assets are important to consider if large scale vaccine production is to be profitable. As can be seen from the data provided, M. chelonii alone is capable of producing prophylaxis to BKD, however, this is likely due to the induction of non-specific immunity and not to the existence of crossreactive antigens. Therefore, future studies should be devoted to further work on the induction of specific immunoprophylaxis incorporating this agent.

Kaattari, Stephen L.

1989-08-01T23:59:59.000Z

460

EA-0896; Research in Alzheimer's Disease Health Sciences Center - West Virginia University Environmental Assessment and (FONSI) Center For Nuclear Medicine Research In Alzheimer's Disease Health Sciences Center - West Virginia University  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

6; Research in Alzheimer's Disease Health Sciences Center - West 6; Research in Alzheimer's Disease Health Sciences Center - West Virginia University Environmental Assessment and (FONSI) Center for Nuclear Medicine Research in Alzheimer's Disease Health Sciences Center - West Virginia University TABLE OF CONTENTS 1.0 DOCUMENT SUMMARY 1.1. Description 1.2 Alternatives 1.3 Affected Environment 1.4 Construction Impacts 1.5 Operating Impacts 2.0 PURPOSE AND NEED FOR AGENCY ACTION 3.0 DESCRIPTION OF ALTERNATIVES INCLUDING THE PROPOSED ACTION 3.1 Description of the Proposed Action 3.2.1 Construction Activities 3.2.2 Operation Activities 3.3 The No Action Alternative 3.4 Site Alternatives 4.0 THE AFFECTED ENVIRONMENT 5.0 ENVIRONMENTAL CONSEQUENCES OF THE PROPOSED ACTION AND ALTERNATIVES 5.1 Construction Impacts 5.1.1 Sensitive Resources

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

X-ray Method Shows How Frog Embryos Could Help Thwart Disease  

NLE Websites -- All DOE Office Websites (Extended Search)

Nanocrystals Grow from Liquid Interface Nanocrystals Grow from Liquid Interface Eleventh Arthur H. Compton Award Announced Borland Awarded ACFA-IPAC'13 Prize for Accelerator Science President Obama at the Advanced Photon Source Von Dreele Receives Hanawalt Award APS News Archives: 2012 | 2011 | 2010 | 2009 2008 | 2007 | 2006 | 2005 2004 | 2003 | 2002 | 2001 2000 Subscribe to APS News rss feed X-ray Method Shows How Frog Embryos Could Help Thwart Disease MAY 20, 2013 Bookmark and Share X-ray phase-contrast tomography: Early frog embryo in cellular resolution (left) and cell and tissue motion captured and visualized using flow analysis (right). Image: Alexey Ershov/KIT From R&D Magazine online: An international team of scientists using a new X-ray method recorded the internal structure and cell movement inside a living frog embryo in greater

462

"Artificial" brains, electrical grids, and disease modeling: Los Alamos  

NLE Websites -- All DOE Office Websites (Extended Search)

Science discoveries unveiled Science discoveries unveiled "Artificial" brains, electrical grids, and disease modeling: Los Alamos science discoveries unveiled September 15 The event is an opportunity for business leaders and community members to learn about where science is heading, as well as for students to discover potential new career directions. September 8, 2009 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy

463

Detecting Lyme Disease Using Antibody-Functionalized Single-Walled Carbon Nanotube Transistors  

E-Print Network (OSTI)

We examined the potential of antibody-functionalized single-walled carbon nanotube (SWNT) field-effect transistors (FETs) for use as a fast and accurate sensor for a Lyme disease antigen. Biosensors were fabricated on oxidized silicon wafers using chemical vapor deposition grown carbon nanotubes that were functionalized using diazonium salts. Attachment of Borrelia burgdorferi (Lyme) flagellar antibodies to the nanotubes was verified by Atomic Force Microscopy and electronic measurements. A reproducible shift in the turn-off voltage of the semiconducting SWNT FETs was seen upon incubation with Borrelia burgdorferi flagellar antigen, indicative of the nanotube FET being locally gated by the residues of flagellar protein bound to the antibody. This sensor effectively detected antigen in buffer at concentrations as low as 1 ng/ml, and the response varied strongly over a concentration range coinciding with levels of clinical interest. Generalizable binding chemistry gives this biosensing platform the potential to...

Lerner, Mitchell B; Goldsmith, Brett R; Brisson, Dustin; Johnson, A T Charlie

2013-01-01T23:59:59.000Z

464

Review Article Ventilation/Perfusion SPECT for Diagnosis of Pulmonary Embolism and Other Diseases  

E-Print Network (OSTI)

License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. V/PSPECT has the potential to become a first hand tool for diagnosis of pulmonary embolism based on standardized technology and new holistic interpretation criteria. Pretest probability helps clinicians choose the most appropriate objective test for diagnosis or exclusion of PE. Interpretation should also take into account all ventilation and perfusion patterns allowing diagnosis of other cardiopulmonary diseases than PE. In such contexts, V/PSPECT has excellent sensitivity and specificity. Nondiagnostic reports are ?3%. V/PSPECT has no contraindication; it is noninvasive and has very low radiation exposure. Moreover, acquisition time for V/PSPECT is only 20 minutes. It allows quantification of PE extension which has an impact on individual treatment. It is uniquely useful for followup and research. 1.

Marika Bajc; Bjrn Jonson

2010-01-01T23:59:59.000Z

465

Low Prevalence of Chronic Beryllium Disease among Workers at a Nuclear Weapons Research and Development Facility  

SciTech Connect

To study the prevalence of beryllium sensitization (BeS) and chronic beryllium disease (CBD) in a cohort of workers from a nuclear weapons research and development facility. We evaluated 50 workers with BeS with medical and occupational histories, physical examination, chest imaging with HRCT (N=49), and pulmonary function testing. Forty of these workers also underwent bronchoscopy for bronchoalveolar lavage (BAL) and transbronchial biopsies. The mean duration of employment at the facility was 18 yrs and the mean latency (from first possible exposure) to time of evaluation was 32 yrs. Five of the workers had CBD at the time of evaluation (based on histology or HRCT); three others had evidence of probable CBD. These workers with BeS, characterized by a long duration of potential Be exposure and a long latency, had a low prevalence of CBD.

Arjomandi, M; Seward, J P; Gotway, M B; Nishimura, S; Fulton, G P; Thundiyil, J; King, T E; Harber, P; Balmes, J R

2010-01-11T23:59:59.000Z

466

Prognostic Factors Depicting Disease-Specific Survival in Parotid-Gland Tumors  

SciTech Connect

Purpose: To identify significant prognostic factors that can be used in clinical decision-making with regard to parotid cancer, which is characterized by a complex and diverse group of tumors with variable outcomes. Methods and Materials: A historical cohort of 184 patients with parotid-gland malignancy, who had been registered in the Province of Manitoba from 1970 to 2003, was examined. Survival analysis was performed using Kaplan-Meier curves and a log-rank test for comparing subgroups. The independent effect of factors that predicted survival at the bivariate level was determined using a Cox proportional hazard model. Results: The mean age at presentation was 62 years. The mean follow-up was 64 months. Absolute and disease-specific survival at 5 years was 41.70% and 57.94%, respectively. Survival for Stages I-IV at 5 years was 85.35%, 76.9%, 56.1%, and 8.4%, respectively (p < 0.0001). Factors with an independent effect on survival (p < 0.05) included age, tumor size, local invasion (Stages T4 vs. T1), and distant metastasis at presentation, tumor differentiation, and treatment. Adjuvant radiotherapy vs. surgery alone reduced the risk of death from disease at 5 years by 50% (hazard ratio [HR], 0.5; 95% confidence interval, 0.228-0.995; p = 0.0486). Conclusions: Despite the variety of malignant parotid tumors, easily identifiable prognostic indicators such as advanced age, tumor size, local invasion, and tumor differentiation have a significant impact on outcome. Patients with adverse prognostic factors benefit from adjuvant radiotherapy. The threshold for the use of adjuvant radiotherapy in managing parotid malignancy should be low.

Koul, Rashmi [Department of Radiation Oncology, CancerCare Manitoba, Winnipeg, Manitoba (Canada); Dubey, Arbind [Department of Radiation Oncology, CancerCare Manitoba, Winnipeg, Manitoba (Canada); Butler, James [Department of Radiation Oncology, CancerCare Manitoba, Winnipeg, Manitoba (Canada); Cooke, Andrew L. [Department of Radiation Oncology, CancerCare Manitoba, Winnipeg, Manitoba (Canada); Abdoh, Ahmed [Department of Surgical Oncology, CancerCare Manitoba, Winnipeg, Manitoba (Canada); Nason, Richard [Department of Surgical Oncology, CancerCare Manitoba, Winnipeg, Manitoba (Canada)]. E-mail: nasonrw@cc.umanitoba.ca

2007-07-01T23:59:59.000Z

467

Geographical Distribution and Density of Ixodes dammini (Acari: Ixodidae) and Relationship to Lyme Disease Transmission in New Jersey  

E-Print Network (OSTI)

As part of continuing studies of Lyme disease, deer were surveyed during three hunting seasons in 1981 to obtain information on geographic distribution and density of. dammini in New Jersey. I. dammini occurred throughout central and southern New Jersey. Four deer management zones (DMZs) were shown to have high tick densities. Geographical distribution and density data were independently regressed against 25 environmental and physical factors. Elevation was shown to be the most important factor in explaining the variability in both I. dammini distribution and density. Lyme disease cases were closely associated with the distribution of I. dammini and 57.3 percent of 117 Lyme disease cases occurred in the four DMZs previously identified as having the highest tick density.

Terry L. Schulze, Ph.D.; A G. Stephen Bowen; Michael F. Lakat; A William E. Parkin; Dr. P. H; A; Joseph K. Shisler, Ph.D.; C

1984-01-01T23:59:59.000Z

468

Cost effective interventions for the prevention of cardiovascular disease in low and middle income countries: a systematic review  

E-Print Network (OSTI)

, Rexrode KM, Kumanyika SK, Appel LJ, Whelton PK: Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). BMJ 2007, 334(7599):885888. 7. Mendis S, Fukino K... , Rexrode KM, Kumanyika SK, Appel LJ, Whelton PK: Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). BMJ 2007, 334(7599):885888. 7. Mendis S, Fukino K...

Shroufi, Amir; Chowdhury, Rajiv; Anchala, Raghupathy; Stevens, Sarah; Blanco, Patricia; Han, Tha; Niessen, Louis; Franco, Oscar H

2013-03-28T23:59:59.000Z

469

Using family history information to promote healthy lifestyles and prevent diseases;a discussion of the evidence  

E-Print Network (OSTI)

information. Phy- sicians have reported time restrictions, lack of reimburse- ment, and the complexity of familial risk interpretation as barriers to the routine and systematic collection and use of family history for disease prevention [68]. Decision support... :248 http://www.biomedcentral.com/1471-2458/10/248 Page 6 of 7 30. Valdez R, Yoon PW, Qureshi N, Green RF, Khoury MJ: Family history in public health practice; a genomic tool for disease prevention and health promotion. Annu Rev Public Health 2010, 31...

Claassen, Liesbeth; Henneman, Lidewij; Janssens, A Cecile J W; Wijdenes-Pijl, Miranda; Qureshi, Nadeem; Walter, Fiona M; Yoon, Paula W; Timmermans, Danielle R M

2010-05-13T23:59:59.000Z

470

Monaural perception under dichotic conditions  

E-Print Network (OSTI)

Most people have two ears, but we can hear with only one ear. The ability to use two ears can substantially improve performance in many circumstances. There are times, however, when the addition of a second ear results in ...

Shub, Daniel E. (Daniel Eric), 1974-

2007-01-01T23:59:59.000Z

471

Variable serum immunoglobulin responses against different Borrelia burgdorferi sensu lato species in a population at risk for and patients with Lyme disease  

E-Print Network (OSTI)

Variable serum immunoglobulin responses against different Borrelia burgdorferi sensu lato species in a population at risk for and patients with Lyme disease.

J Bunikis; B Olsn; G Westman; S Bergstrom; J. Clin Microbiol; Jonas Bunikis; Bjrn Olsn; Gran Westman; Sven Bergstrm

1995-01-01T23:59:59.000Z

472

DOE G 440.1-7A, Implementation Guide for use with 10 CFR Part 850, Chronic Beryllium Disease Prevention Program  

Directives, Delegations, and Requirements

The Department of Energy (DOE) has established regulatory requirements for the Chronic Beryllium Disease Prevention Program (CBDPP) in Title 10 of the Code of ...

2001-01-04T23:59:59.000Z

473

Determining thyroid {sup 131}I effective half-life for the treatment planning of Graves' disease  

Science Conference Proceedings (OSTI)

Purpose: Thyroid {sup 131}I effective half-life (T{sub eff}) is an essential parameter in patient therapy when accurate radiation dose is desirable for producing an intended therapeutic outcome. Multiple {sup 131}I uptake measurements and resources from patients themselves and from nuclear medicine facilities are requisites for determining T{sub eff}, these being limiting factors when implementing the treatment planning of Graves' disease (GD) in radionuclide therapy. With the aim of optimizing this process, this study presents a practical, propitious, and accurate method of determining T{sub eff} for dosimetric purposes. Methods: A total of 50 patients with GD were included in this prospective study. Thyroidal {sup 131}I uptake was measured at 2-h, 6-h, 24-h, 48-h, 96-h, and 220-h postradioiodine administration. T{sub eff} was calculated by considering sets of two measured points (24-48-h, 24-96-h, and 24-220-h), sets of three (24-48-96-h, 24-48-220-h, and 24-96-220-h), and sets of four (24-48-96-220-h). Results: When considering all the measured points, the representative T{sub eff} for all the patients was 6.95 ({+-}0.81) days, whereas when using such sets of points as (24-220-h), (24-96-220-h), and (24-48-220-h), this was 6.85 ({+-}0.81), 6.90 ({+-}0.81), and 6.95 ({+-}0.81) days, respectively. According to the mean deviations 2.2 ({+-}2.4)%, 2.1 ({+-}2.0)%, and 0.04 ({+-}0.09)% found in T{sub eff}, calculated based on all the measured points in time, and with methods using the (24-220-h), (24-48-220-h), and (24-96-220-h) sets, respectively, no meaningful statistical difference was noted among the three methods (p > 0.500, t test). Conclusions: T{sub eff} obtained from only two thyroid {sup 131}I uptakes measured at 24-h and 220-h, besides proving to be sufficient, accurate enough, and easily applicable, attributes additional major cost-benefits for patients, and facilitates the application of the method for dosimetric purposes in the treatment planning of Graves' disease.

Willegaignon, Jose; Sapienza, Marcelo T.; Barberio Coura Filho, George; Buchpiguel, Carlos A. [Cancer Institute of Sao Paulo State (ICESP), Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 01246-000 (Brazil); Nuclear Medicine Service, Department of Radiology, School of Medicine, University of Sao Paulo, Sao Paulo 01246-000 (Brazil); Traino, Antonio C. [Unit of Medical Physics, Azienda Ospedaliero-Universitaria Pisana, Pisa 56126 (Italy)

2013-02-15T23:59:59.000Z

474

Most of rare missense alleles in humans are deleterious:implications for evolution of complex disease and associationstudies  

SciTech Connect

The accumulation of mildly deleterious missense mutations inindividual human genomes has been proposed to be a genetic basis forcomplex diseases. The plausibility of this hypothesis depends onquantitative estimates of the prevalence of mildly deleterious de novomutations and polymorphic variants in humans and on the intensity ofselective pressure against them. We combined analysis of mutationscausing human Mendelian diseases, human-chimpanzee divergence andsystematic data on human SNPs and found that about 20 percent of newmissense mutations in humans result in a loss of function, while about 27percent are effectively neutral. Thus, more than half of new missensemutations have mildly deleterious effects. These mutations give rise tomany low frequency deleterious allelic variants in the human populationas evident from a new dataset of 37 genes sequenced in over 1,500individual human chromosomes. Surprisingly, up to 70 percent of lowfrequency missense alleles are mildly deleterious and associated with aheterozygous fitness loss in the range 0.001-0.003. Thus, the low allelefrequency of an amino acid variant can by itself serve as a predictor ofits functional significance. Several recent studies have reported asignificant excess of rare missense variants in disease populationscompared to controls in candidate genes or pathways. These studies wouldbe unlikely to work if most rare variants were neutral or if rarevariants were not a significant contributor to the genetic component ofphenotypic inheritance. Our results provide a justification for thesetypes of candidate gene (pathway) association studies and imply thatmutation-selection balance may be a feasible mechanism for evolution ofsome common diseases.

Kryukov, Gregory V.; Pennacchio, Len A.; Sunyaev, Shamil R.

2006-10-24T23:59:59.000Z

475

Challenges in Improving Sensitivity for Quantification of PET Data in Alzheimer's Disease Studies: Image Restoration and Registration  

E-Print Network (OSTI)

of Aging, [8], recently published recom- mendations for studies on aging that utilize imaging data, ac the lives of those with the disease and their care givers, as well as the entire medical infrastructure analysis · Utilizing Results: longitudinal, comparitive studies · Studies collect images, not original

Renaut, Rosemary

476

Two approaches to selecting set of voxels for the diagnosis of Alzheimer's disease using brain SPECT images  

Science Conference Proceedings (OSTI)

This paper presents a computer-aided diagnosis technique for improving the accuracy of the early diagnosis of the Alzheimer type dementia. The first proposed methodology is based on the selection of those voxels which present a greater difference between ... Keywords: Alzheimer's disease, Computer aided diagnosis, SPECT brain images

D. Salas-Gonzalez; J. M. Grriz; J. Ramrez; I. lvarez; M. Lpez; F. Segovia; C. G. Puntonet

2011-12-01T23:59:59.000Z

477

Photographer: Unknown Prepared by U.S. Department of Health and Human Services Agency for Toxic Substances and Disease Registry  

E-Print Network (OSTI)

serves the public by using the best science, taking responsive public health actions, and providing trusted health information to prevent harmful exposures and diseases related to toxic substances. You may contact ATSDR toll free at 800-CDC-INFO (800-232-4636)

unknown authors

2008-01-01T23:59:59.000Z

478

The Effects of Anti-Hypertensive Drugs Evaluated Using Markov Modelling for Northern Ireland Chronic Kidney Disease Patients  

Science Conference Proceedings (OSTI)

The aim of this paper is to use Markov modelling to investigate survival for particular types of kidney patients in relation to their exposure to anti-hypertensive treatment drugs. In order to monitor kidney function an intuitive three point assessment ... Keywords: Markov Modelling, Chronic Kidney Disease, Anti-Hypertensive Drugs

Andrea Rainey; Karen Carins; Adele Marshall; Michael Quinn; Gerard Savage; Damian Fogarty

2008-06-01T23:59:59.000Z

479

Biocompatibility of an implantable ophthalmic drug delivery device  

E-Print Network (OSTI)

Diseases of the posterior eye present clinicians with a treatment challenge mainly due to the region's inaccessible location. Several drugs, including those available for the treatment of exudative age-related macular ...

Cohen, Sarah J. (Sarah Jennifer)

2007-01-01T23:59:59.000Z

480

Duodenal prostaglandin synthesis and acid load in health and in duodenal ulcer disease  

SciTech Connect

We sought to test the hypothesis that duodenal ulcer disease results from an imbalance between duodenal acid load, an injurious force, and mucosal prostaglandin generation, a protective factor. Ten patients with duodenal ulcer and 8 healthy controls were studied. The duodenal acid load after an amino acid soup was quantified by a double-marker technique. Mucosal biopsy specimens were taken endoscopically from the duodenal bulb before and after the test meal. Prostaglandin synthesis activity was measured by incubating biopsy homogenates in excess (/sup 14/C)arachidonic acid. Although mean duodenal acid load was higher in duodenal ulcer, ranges overlapped. Neither the qualitative nor quantitative profile of mucosal prostaglandin synthesis activities differed significantly between test groups. Prostaglandin synthesis activities, however, tended to increase post cibum in controls, but change little or decrease in duodenal ulcer. Only by comparing the responses with a meal of both parameters together (duodenal acid load and the change in prostaglandin synthesis activities) was there complete or nearly complete separation of duodenal ulcer from controls. Greatest discrimination was observed with prostacyclin (6-keto-PGF1 alpha). We conclude that in health, mucosal prostaglandin generation in the duodenum is induced post cibum in relation to duodenal acid load; this may be a physiologic example of adaptive cytoprotection. In duodenal ulcer there may be a defect in such a mechanism.

Ahlquist, D.A.; Dozois, R.R.; Zinsmeister, A.R.; Malagelada, J.R.

1983-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "disease ear eye" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Agency for Toxic Substances and Disease RegistryForeword: ATSDRs National Asbestos Exposure Review  

E-Print Network (OSTI)

now know that this vermiculite, which was shipped to many locations around the U.S. for processing, contained asbestos. The National Asbestos Exposure Review (NAER) is a project of the Agency for Toxic Substances and Disease Registry (ATSDR). ATSDR is working with other federal, state, and local environmental, and public health agencies to evaluate public health impacts at sites that processed Libby vermiculite. The evaluations focus on the processing sites and on human health effects that might be associated with possible past or current exposures. They do not consider commercial or consumer use of the products of these facilities. The sites that processed Libby vermiculite will be evaluated by (1) identifying ways people could have been exposed to asbestos in the past and ways that people could be exposed now and (2) determining whether the exposures represent a public health hazard. ATSDR will use the information gained from the site-specific investigations to recommend further public health actions as needed. Site evaluations are progressing in two phases: Phase 1: ATSDR has selected 28 sites for the first phase of reviews on the basis of the following

Vermiculite Northwest

2004-01-01T23:59:59.000Z

482

Genomic deletion of a long-range bone enhancer misregulatessclerostin in Van Buchem disease  

Science Conference Proceedings (OSTI)

Mutations in distant regulatory elements can negatively impact human development and health, yet due to the difficulty of detecting these critical sequences we predominantly focus on coding sequences for diagnostic purposes. We have undertaken a comparative sequence-based approach to characterize a large noncoding region deleted in patients affected by Van Buchem disease (VB), a severe sclerosing bone dysplasia. Using BAC recombination and transgenesis we characterized the expression of human sclerostin (sost) from normal (hSOSTwt) or Van Buchem(hSOSTvb D) alleles. Only the hSOSTwt allele faithfully expressed high levels of human sost in the adult bone and impacted bone metabolism, consistent with the model that the VB noncoding deletion removes a sost specific regulatory element. By exploiting cross-species sequence comparisons with in vitro and in vivo enhancer assays we were able to identify a candidate enhancer element that drives human sost expression in osteoblast-like cell lines in vitro and in the skeletal anlage of the E14.5 mouse embryo, and discovered a novel function for sclerostin during limb development. Our approach represents a framework for characterizing distant regulatory elements associated with abnormal human phenotypes.

Loots, Gabriela G.; Kneissel, Michaela; Keller, Hansjoerg; Baptist, Myma; Chang, Jessie; Collette, Nicole M.; Ovcharenko, Dmitriy; Plajzer-Frick, Ingrid; Rubin, Edward M.

2005-04-15T23:59:59.000Z

483

Spectral Imaging II: Plant disease detection based on data fusion of hyper-spectral and multi-spectral fluorescence imaging using Kohonen maps  

Science Conference Proceedings (OSTI)

The objective of this research was to develop a ground-based real-time remote sensing system for detecting diseases in arable crops under field conditions and in an early stage of disease development, before it can visibly be detected. This was achieved ...

D. Moshou; C. Bravo; R. Oberti; J. West; L. Bodria; A. McCartney; H. Ramon

2005-04-01T23:59:59.000Z

484

If you have heart disease, or think you do, there's a lot you can do to protect your heart health. This fact sheet  

E-Print Network (OSTI)

If you have heart disease, or think you do, there's a lot you can do to protect your heart health. This fact sheet gives you the key steps to control the disease, including how to survive a heart attack and prevent serious dam- age to heart muscle. Caring for your heart is worth the effort. Use the information

Bandettini, Peter A.

485

An improved assay for the determination of Huntington`s disease allele size  

Science Conference Proceedings (OSTI)

The hallmark of Huntington`s disease (HD) is the expansion of a polymorphic (CAG)n repeat. Several methods have been published describing PCR amplification of this region. Most of these assays require a complex PCR reaction mixture to amplify this GC-rich region. A consistent problem with trinucleotide repeat PCR amplification is the presence of a number of {open_quotes}stutter bands{close_quotes} which may be caused by primer or amplicon slippage during amplification or insufficient polymerase processivity. Most assays for HD arbitrarily select a particular band for diagnostic purposes. Without a clear choice for band selection such an arbitrary selection may result in inconsistent intra- or inter-laboratory findings. We present an improved protocol for the amplification of the HD trinucleotide repeat region. This method simplifies the PCR reaction buffer and results in a set of easily identifiable bands from which to determine allele size. HD alleles were identified by selecting bands of clearly greater signal intensity. Stutter banding was much reduced thus permitting easy identification of the most relevant PCR product. A second set of primers internal to the CCG polymorphism was used in selected samples to confirm allele size. The mechanism of action of N,N,N trimethylglycine in the PCR reaction is not clear. It may be possible that the minimal isostabilizing effect of N,N,N trimethylglycine at 2.5 M is significant enough to affect primer specificity. The use of N,N,N trimethylglycine in the PCR reaction facilitated identification of HD alleles and may be appropriate for use in other assays of this type.

Reeves, C.; Klinger, K.; Miller, G. [Intergrated Genetics, Framingham, MA (United States)

1994-09-01T23:59:59.000Z

486

Studies on Pentoxifylline and Tocopherol Combination for Radiation-Induced Heart Disease in Rats  

SciTech Connect

Purpose: To investigate whether the application of pentoxifylline (PTX) and tocopherol l (Vit. E) could modify the development of radiation-induced heart disease and downregulate the expression of transforming growth factor (TGF)-{beta}1mRNA in rats. Methods and Materials: A total of 120 Sprague-Dawley rats were separated into four groups: control group, irradiated group, experimental group 1, and experiment group 2. Supplementation was started 3 days before irradiation; in experimental group 1, injection of PTX (15 mg/kg/d) and Vit. E (5.5 mg/kg/d) continued till the 12th week postirradiation, whereas in experimental group 2 it was continued until the 24th week postirradiation. All rats were administrated a single dose of 20 Gy irradiation to the heart except the control group. Histopathologic evaluation was performed at various time points (Days 1, 2, 4, 8, and 12 and 24th week) up to 24 weeks after irradiation. Changes of levels of TGF-{beta}1 mRNA expression were also investigated at the same time points using competitive polymerase chain reaction. Results: Compared with the irradiated group, levels of TGF-{beta}1 mRNA of the rat hearts were relatively low in the two experimental groups on the 12th week postirradiation. In experimental group 1, there was a rebound expression of TGF-{beta}1 mRNA on the 24th week postirradiation, whereas that of the experimental group 2 remained low (p < 0.05). The proportions of collagen fibers of the two experimental groups were lower than that of irradiated group (p < 0.05). A rebound could be observed in the experimental group 1. Conclusion: PTX and Vit. E downregulated the expression of TGF-{beta}1 mRNA. The irradiated rat hearts showed a marked pathologic response to the drugs. The withdrawal of drugs in the 12th week postirradiation could cause rebound effects of the development of fibrosis.

Liu Hui [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Xiong Mai [Department of Cardiac Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong (China); Xia Yunfei; Cui Nianji; Lu Rubiao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Deng Ling [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Lin Yuehao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Clinical Laboratory, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Rong Tiehua [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China)], E-mail: esophagus2003@yahoo.com.cn

2009-04-01T23:59:59.000Z

487

Genome Stability of Lyme Disease Spirochetes: Comparative Genomics of Borrelia burgdorferi Plasmids  

Science Conference Proceedings (OSTI)

Lyme disease is the most common tick-borne human illness in North America. In order to understand the molecular pathogenesis, natural diversity, population structure and epizootic spread of the North American Lyme agent, Borrelia burgdorferi sensu stricto, a much better understanding of the natural diversity of its genome will be required. Towards this end we present a comparative analysis of the nucleotide sequences of the numerous plasmids of B. burgdorferi isolates B31, N40, JD1 and 297. These strains were chosen because they include the three most commonly studied laboratory strains, and because they represent different major genetic lineages and so are informative regarding the genetic diversity and evolution of this organism. A unique feature of Borrelia genomes is that they carry a large number of linear and circular plasmids, and this work shows that strains N40, JD1, 297 and B31 carry related but non-identical sets of 16, 20, 19 and 21 plasmids, respectively, that comprise 33-40% of their genomes. We deduce that there are at least 28 plasmid compatibility types among the four strains. The B. burgdorferi {approx}900 Kbp linear chromosomes are evolutionarily exceptionally stable, except for a short {le}20 Kbp plasmid-like section at the right end. A few of the plasmids, including the linear lp54 and circular cp26, are also very stable. We show here that the other plasmids, especially the linear ones, are considerably more variable. Nearly all of the linear plasmids have undergone one or more substantial inter-plasmid rearrangements since their last common ancestor. In spite of these rearrangements and differences in plasmid contents, the overall gene complement of the different isolates has remained relatively constant.

Casjens S. R.; Dunn J.; Mongodin, E. F.; Qiu, W.-G.; Luft, B. J.; Schutzer, S. E.; Gilcrease, E. B.; Huang, W. M.; Vujadinovic, M.; Aron, J. K.; Vargas, L. C.; Freeman, S.; Radune, D.; Weidman, J. F.; Dimitrov, G. I.; Khouri, H. M.; Sosa, J. E.; Halpin, R. A.; Fraser, C. M.

2012-03-14T23:59:59.000Z

488

Targeted deletion of the 9p21 noncoding coronary artery disease risk interval in mice  

SciTech Connect

Sequence polymorphisms in a 58kb interval on chromosome 9p21 confer a markedly increased risk for coronary artery disease (CAD), the leading cause of death worldwide 1,2. The variants have a substantial impact on the epidemiology of CAD and other life?threatening vascular conditions since nearly a quarter of Caucasians are homozygous for risk alleles. However, the risk interval is devoid of protein?coding genes and the mechanism linking the region to CAD risk has remained enigmatic. Here we show that deletion of the orthologous 70kb noncoding interval on mouse chromosome 4 affects cardiac expression of neighboring genes, as well as proliferation properties of vascular cells. Chr4delta70kb/delta70kb mice are viable, but show increased mortality both during development and as adults. Cardiac expression of two genes near the noncoding interval, Cdkn2a and Cdkn2b, is severely reduced in chr4delta70kb/delta70kb mice, indicating that distant-acting gene regulatory functions are located in the noncoding CAD risk interval. Allelespecific expression of Cdkn2b transcripts in heterozygous mice revealed that the deletion affects expression through a cis-acting mechanism. Primary cultures of chr4delta70kb/delta70kb aortic smooth muscle cells exhibited excessive proliferation and diminished senescence, a cellular phenotype consistent with accelerated CAD pathogenesis. Taken together, our results provide direct evidence that the CAD risk interval plays a pivotal role in regulation of cardiac Cdkn2a/b expression and suggest that this region affects CAD progression by altering the dynamics of vascular cell proliferation.

Visel, Axel; Zhu, Yiwen; May, Dalit; Afzal, Veena; Gong, Elaine; Attanasio, Catia; Blow, Matthew J.; Cohen, Jonathan C.; Rubin, Edward M.; Pennacchio, Len A.

2010-01-01T23:59:59.000Z

489

New WEBGIS technologies for geolocation of epidemiological data: an application for the surveillance of the risk of Lyme borrelliosis disease  

E-Print Network (OSTI)

We present a technology for the accurate and fast geo-location of medical data and the creation of central data archives, specifically designed for the development of disease risk maps and of other functions for modern epidemiology and surveillance. A WEBGIS system is configured as an Internet web service integrated with connectivity to a Geographical Information System (GIS). We developed for the ULSS Belluno a WEBGIS for the accurate mapping of tick-borne diseases, with specific attention to Lyme borreliosis, which may cause cardiac manifestations as atrioventricular conduction abnormalities, complete atrioventricular block, myocarditis and dilated cardiomiopathy. A first tree-based predictive model has been developed for risk classification of tick bites from 256 samples (data gathered through the Belluno Lyme WEBGIS), with a descriptive accuracy of 81.9% and a predictive accuracy of 75.1% . An experimental risk GIS map was therefore obtained from the model by considering altitude, week of sampling and vegetation type as predictor variables.

C. Furlanello; Cesare Furlanello; S. Merler; S. Mancuso; S. Menegon; Sebastiano Mancuso; G. Bertiato

2002-01-01T23:59:59.000Z

490

Office of Health, Safety and Security Follow-up Review of the Hanford Site Chronic Beryllium Disease Prevention Program  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Follow-up Review of the Follow-up Review of the Hanford Site Chronic Beryllium Disease Prevention Program May 2011 June 2011 Office of Safety and Emergency Management Evaluations Office of Health, Safety and Security U.S. Department of Energy TABLE OF CONTENTS 1.0 Purpose ................................................................................................................................... 1 2.0 Background ............................................................................................................................ 1 3.0 Scope ...................................................................................................................................... 1 4.0 Results .................................................................................................................................... 1

491

THE PATHOGENESIS OF ALEUTIAN DISEASE OF MINK I. IN VlVO VIRAL REPLICATION AND THE HOST ANTIBODY RESPONSE TO  

E-Print Network (OSTI)

Aleutian disease (AD) is a common chronic virus disease of mink, which may cause serious economic losses to commercial ranchers. The most consistent and striking feature of AD is that once a mink has been infected with Aleutian disease virus (ADV), infectious virus may be recovered from the serum, organs, and urine for the remainder of the animal's life (1-4). ADV in the serum of such mink has been shown to exist as an infectious virus-antibody complex (5). The primary lesion of AD is a systemic proliferation of plasma cells. A marked hypergammaglobulinemia, which may change into a monoclonal gammopathy, is secondary to the plasma cell proliferation (6-8). Glomerulonephritis, degenerative arterial lesions, and proliferation of intrahepatic bile ducts are frequently seen in AD (9-11). The markedly increased gamma globulin in AD is the result of overproduction, and has been found to have some degree of specificity (7, 12, 13). However, except for the infectious complexes, antibody to ADV antigens has not been previously demonstrated. The present study was undertaken to define the early and late stages of

Vmal Antigen; Austin E. Larsen; Helen G. Porter

1969-01-01T23:59:59.000Z

492

Natural Product Biosynthesis: Friend or Foe? From Anti-tumor Agent to Disease Causation  

E-Print Network (OSTI)

Biosynthetic natural products are invaluable resources that have been gleaned from the environment for generations, and they play an essential role in drug development. Natural product biosynthesis also possesses the latent ability to affect biological systems adversely. This work implements recent advances in genomic, proteomic and microbiological technologies to understand further biosynthetic molecules that may influence progression of human disease. Azinomycin A and B are antitumor metabolites isolated from the terrestrial bacterium Streptomyces sahachiroi. The azinomycins possess an unusual aziridine [1,2-a] pyrrolidine ring that reacts in concert with an epoxide moiety to produce DNA interstrand cross-links. Genomic sequencing of S. sahachiroi revealed a putative azinomycin resistance protein (AziR). Overexpression of AziR in heterologous hosts demonstrated the protein increases cell viability and decreases DNA damage response in the presence of azinomycin. Fluorescence titration indicated AziR functions as an azinomycin binding protein. An understanding of azinomycin resistance is important for future engineering and drug delivery strategies. Additionally, the S. sahachiroi draft genome obtained via 454 pyrosequencing and Illumina sequencing revealed several silent secondary metabolic pathways that may provide new natural products with biomedical application. ?-lactoglobulin (BLG), the most abundant whey protein in bovine milk, has been observed to promote the self-condensation of retinal and similar ?,?-unsaturated aldehydes. BLG is a possible non-genetic instigator of cycloretinal and A2E accumulation in the macula, a condition associated with age-related macular degeneration. BLG-mediated terpenal condensation has been optimized for in vitro study with the retinal mimic citral. In rabbits fed retinal and BLG or skim milk, cycloretinal formation was detected in the blood by 1H-NMR, and SDS-PAGE analysis indicated BLG was present in blood serum, suggesting the protein survives ingestion and retains catalytic activity. Mass spectrometry and site-directed mutagenesis provided mechanistic insight toward this unusual moonlighting behavior. The experiments described in this dissertation serve to further natural product biosynthesis discovery and elucidation as they relate to consequences for human health. Efforts to solve azinomycin biosynthesis via enzymatic reconstitution, characterize compounds produced by orphan gene clusters within S. sahachiroi, and obtain a clear mechanism for BLG-promoted cycloterpenal formation are immediate goals within the respective projects.

Foulke-Abel, Jennifer

2010-12-01T23:59:59.000Z

493

The nature of habits in the nonhuman primate : the formation of sequences of eye movements and neural activity in the frontal eye field  

E-Print Network (OSTI)

The nature of habits, their formation, expression, and underlying causes have been pondered for centuries. Early definitions, still in use today, posited that habits are actions associated with outcomes that, when repeated, ...

Desrochers, Theresa M

2011-01-01T23:59:59.000Z

494

Dietary Fats and Risk of Chronic DiseaseChapter 7 Dietary Conjugated Linolenic Acid Modifies Body Fat Mass, and Serum and Liver Lipid Levels in Rats  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 7 Dietary Conjugated Linolenic Acid Modifies Body Fat Mass, and Serum and Liver Lipid Levels in Rats Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press ...

495

Dietary Fats and Risk of Chronic DiseaseCh 10 Suppression of Leukotriene B4 Generation by ex vivo Neutrophils Isolated from Asthma Patients  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Ch 10 Suppression of Leukotriene B4 Generation by ex vivo Neutrophils Isolated from Asthma Patients Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press ...

496

The identification of chemical compounds that decrease cellular levels of toxic Huntington's disease protein through a novel cell-based assay  

E-Print Network (OSTI)

Huntington's disease (HD) is a progressive degenerative neurological disorder. Individuals who inherit the IT15 gene with an expansion of the CAG repeat region inevitably succumb to increasingly sever motor, psychological, ...

Coufal, Myra Alfert

2006-01-01T23:59:59.000Z

497

Dietary Fats and Risk of Chronic DiseaseChapter 4 A Clinically Relevant Lipid Model for South African Patients with Laryngeal Cancer  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 4 A Clinically Relevant Lipid Model for South African Patients with Laryngeal Cancer Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downlo

498

Dietary Fats and Risk of Chronic DiseaseChapter 18 Is There a Role for Conjugated Linoleic Acid to Aid in the Prevention of Type 2 Diabetes?  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 18 Is There a Role for Conjugated Linoleic Acid to Aid in the Prevention of Type 2 Diabetes? Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press ...

499

Dietary Fats and Risk of Chronic DiseaseChapter 3 Chemopreventive Effect of Bitter Gourd Seed Oil Rich in Conjugated Linolenic Acid  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 3 Chemopreventive Effect of Bitter Gourd Seed Oil Rich in Conjugated Linolenic Acid Health Biochemistry eChapters Health - Nutrition - Biochemistry Nutrition Press Downloa