National Library of Energy BETA

Sample records for disease ear eye

  1. Digital ear scanner : measuring the compliance of the ear

    E-Print Network [OSTI]

    Hernandez-Stewart, Daniel

    2010-01-01

    This paper seeks to resolve the biggest problem with hearing aids, their physical fit. By digitally scanning the ear canal and taking the dynamics of the ear into account the performance and comfort of a hearing aid can ...

  2. Vannida Ket Disease Case Presentation

    E-Print Network [OSTI]

    Brutlag, Doug

    -Sachs disease is classically diagnosed by an eye examination or behavior observation. Ganglion cells in the eye

  3. Bovine Respiratory Disease Pathogens in Pre-weaned Holstein Calves

    E-Print Network [OSTI]

    Collins, Gary S.

    , presence of nasal discharge and cough, and eye or ear appearance. Scores ranged from 0 to 12 with calves such as fever, rapid breathing, repetitive coughing, nasal and/or eye discharge, diarrhea, dehydration

  4. Enhanced sensitivity and specificity of thallium-201 imaging for the detection of regional ischemic coronary disease by combining SPECT with bull's eye analysis

    SciTech Connect (OSTI)

    Kasabali, B.; Woodard, M.L.; Bekerman, C.; Pinsky, S.; Blend, M.J. (Michael Reese Hospital and Medical Center, Chicago, IL (USA))

    1989-07-01

    Previous studies have indicated that the combination of single photon emission computed tomography (SPECT) and quantitative bull's eye analysis (QBA) TI-201 cardiac stress imaging may improve the detection of myocardial ischemia over that achieved with planar (PLN) imaging. This study will evaluate the sensitivity and specificity of SPECT and QBA in the detection of disease in the left anterior descending (LAD), left circumflex (LCX), and right coronary artery. Ninety-nine patients who underwent both TI-201 stress imaging and coronary arteriography were evaluated retrospectively. Of the 99, 62 had PLN imaging and 37 were evaluated with SPECT; 23 of these 37 had QBA. The overall sensitivity and specificity were as follows: PLN, 94% and 50%; SPECT, 90% and 67%; QBA, 100% and 20%; and SPECT with QBA, 92% and 72%, respectively. The regional sensitivity and specificity of PLN for individual coronary arteries were as follows: RCA, 78% and 74%; LAD, 89% and 60%; LCX, 50% and 89%, respectively. For SPECT, the results were: RCA, 86% and 93%; LAD, 85% and 88%; and LCX, 60% and 88%. For QBA alone, the results were: RCA, 100% and 75%; LAD, 88% and 53%; and LCX, 100% and 89%. The results for QBA with SPECT were: RCA, 100% and 94%; LAD, 88% and 80%; and LCX, 67% and 95%. Thus, SPECT interpreted on conjunction with QBA showed higher sensitivity for evaluation of ischemia in the RCA and LCX arteries and higher specificity in the detection of LAD and RCA disease than did PLN TI-201 imaging. Because of the low specificity of QBA (20%), caution is advised in the interpretation of QBA alone without reviewing SPECT images.

  5. An Ultra-Low-Power Programmable Analog Bionic Ear Processor

    E-Print Network [OSTI]

    Sarpeshkar, Rahul

    2004-09-28

    We report a programmable analog bionic ear (cochlear implant) processor in a 1.5µm BiCMOS technology with a power

  6. Lasers, fish ears and environmental change | ornl.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lasers, fish ears and environmental change ORNL and TVA team up to study Kingston spill restoration efforts Researchers analyze fish otoliths using a laser to understand...

  7. Eagle-Eye of the Yard can spot rioters by their ears

    E-Print Network [OSTI]

    Duchaine, Bradley C.

    to be named, patrols London's transport system. He has received an official summer's London riots, you had better hope you never meet Idris the Jailer London, is one of an elite squad with exceptional memories for faces who

  8. With McLuhan in Nigeria, Item I: An Eye for an Ear?

    E-Print Network [OSTI]

    Kinner, Joseph

    1971-01-01

    has just r eturned from a year of field work in Nigeria . atpp. 112-113. Coleman, Nigeria, pp. 113-114. W.H. Whiteley, AEducation in Northern Nigeria, (lbadan, 1966), p. 101. See

  9. Ear Problems Approved by the UHS Patient Education Committee

    E-Print Network [OSTI]

    feeling in the ear and/or ringing in the ear. Using Q-tips may cause the problem by impacting the wax. Wax. Occasionally some individuals produce excess wax and OTC earwax softeners/removal products such as Debrox can

  10. THE SCARIEST PLACE ON EARTH : EYE TO EYE WITH HURRICANES

    E-Print Network [OSTI]

    Morss, Dean A.

    1995-01-01

    an authoritative treatise on hurricane forecasting. To do soON EARTH : EYE TO EYE WITH HURRICANES. New York, NY: Randomof the influence of the hurricane (and to a lesser extent,

  11. Energy extraction from the biologic battery in the inner ear

    E-Print Network [OSTI]

    Bandyopadhyay, Saurav

    Endocochlear potential (EP) is a battery-like electrochemical gradient found in and actively maintained by the inner ear [superscript 1, 2]. Here we demonstrate that the mammalian EP can be used as a power source for ...

  12. The ear as a location for wearable vital signs monitoring

    E-Print Network [OSTI]

    He, David Da

    Obtaining vital signs non-invasively and in a wearable manner is essential for personal health monitoring. We propose the site behind the ear as a location for an integrated wearable vital signs monitor. This location is ...

  13. Look Through My Eyes 

    E-Print Network [OSTI]

    Carnall, J.; Craig, N.

    1991-01-01

    . With an abrupt mastery of cowardice, he put his hand to the door and shoved it open. There was a single bed in the room, and Cowley lay on it, unmoving. on his back. his arm.s flat by his sides. Going briskly over. Bodie stood at the foot of the bed, studying... his face did not change, because it was 6S impersonal as if he were kicking a box out of his way. The man put a hand round his throat and jerked his head up, so that Cowley could not but look him in the eye. "If you run again, we will blow your legs...

  14. Regional companies eye growth

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) by Carbon-RichProtonAbout UsRegional companies eye growth Regional

  15. John A. Moran Eye Center

    E-Print Network [OSTI]

    Marc, Robert E.

    Normann Professor of Biomedical Engineering Adjunct Professor of Ophthalmology Artificial Vision Bradley#12;The John A. Moran Eye Center 2011 Visualizing Vision #12;John A. Moran Eye Center Research Profile · The Vision Institute · 21 NIH grants (18 JMEC, Vision Core) · 20 research

  16. EARS: Toward Fast Analysis of 3D Human

    E-Print Network [OSTI]

    State University 7171 E. Sonaran Arroyo Mall, Mesa, AZ 85212, USA 2. Brian.Corner@us.army.mil Ergonomics, visualize, and evaluate the geometric information of a 3D human body scan. To the best of our knowledge, EARS is the first complete system dedicated to fast evaluation and analysis of the quality of a human

  17. Spike Response Properties of an AER EAR Vincent Chan#

    E-Print Network [OSTI]

    Liu, Shih-Chii

    Spike Response Properties of an AER EAR Vincent Chan# , André van Schaik# and Shih-Chii Liu. INTRODUCTION For multi-chip neuromorphic systems, the Address Event Representation (AER) interface has become the standard interface protocol. The AER approach allows us to model biological systems using discrete level

  18. EARS IN MEXICO: A CULTURAL HISTORY OF EMOTIONS AND MOTIVATIONS

    E-Print Network [OSTI]

    Indiana University

    T EARS IN MEXICO: A CULTURAL HISTORY OF EMOTIONS AND MOTIVATIONS Tuesday, September 16th, 4:00 p war studies. She is the author of Photog- raphy and Memory in Mexico: Icons of Revolution (Manchester of New Mexico, 2000). She has also published numerous articles and guest edited a special issue

  19. Auditory Responses in Normal-Hearing, Noise-Exposed Ears

    E-Print Network [OSTI]

    Stamper, Greta

    2013-12-31

    and a click stimulus. DPOAEs were assessed at 1, 2 and 4 kHz. Significantly smaller amplitudes were seen in wave I of the ABR in response to high-level (e.g., 70 to 90 dB nHL) click and 4 kHz tone bursts in ears with greater noise-exposure backgrounds...

  20. Listening Through Different Ears Alters Spatial Response Fields in Ferret Primary Auditory Cortex

    E-Print Network [OSTI]

    Jenison, Rick L.

    primary auditory cortex using virtual sound sources based either on the animal's own ears or on the ears reports showing that humans localize less accurately when listening to virtual sounds from other of other subjects. For 73% of units, the response fields measured using the animals' own ears differed

  1. Eye movements in risky choice

    E-Print Network [OSTI]

    Stewart, Neil; Hermens, Frouke; Matthews, William J.

    2015-01-26

    & Findlay, 2000; Rayner, 1998, 2009; Yarbus, 1967). Glaholt and Reingold (2011), Orquin and Mueller Loose (2013), and Russo (2011) all provide comprehensive reviews of eye tracking in the decision making literature, so we will just outline some key relevant... issues. EYE TRACKING AND DECISION MAKING The final fixation made at the point of choice is strongly bi- assed towards the chosen option (Fiedler & Glöckner, 2012; Glaholt & Reingold, 2009b; Krajbich et al., 2010; Schotter, Berry, McKenzie, & Rayner, 2010...

  2. THE GAS BLADDER AND ITS RELATION TO THE INNER EAR IN SARDINOPS

    E-Print Network [OSTI]

    THE GAS BLADDER AND ITS RELATION TO THE INNER EAR IN SARDINOPS CAERULEA AND ENGRAULIS MORDAXO'rcla;1J) , an anatomical study of the gas bladder has been made in both speeies. As in all clupeoid fishes, the gas bladders of these species .have a close anatomical relation with the inner ears

  3. Periodicity detection and localization using spike timing from the AER EAR

    E-Print Network [OSTI]

    Liu, Shih-Chii

    Periodicity detection and localization using spike timing from the AER EAR Theodore Yu1 , Andrew Event Representation (AER) where each spike carries the identity of the sender. There are a handful of silicon cochleae with an Address Event type representation [4][5][6][7]. The AER EAR chip that we use

  4. Prediction of a Mysticete Audiogram via Finite Element Analysis of the Middle Ear

    E-Print Network [OSTI]

    Prediction of a Mysticete Audiogram via Finite Element Analysis of the Middle Ear Andrew Tubelli (Rosowski 1994). Biophysical models of the cetacean middle ear can be developed using finite element (FE for FE analysis (COMSOL, Stockholm, Sweden). _________________________ A. Tubelli (!) · A. Zosuls · D

  5. Postoperative Intensity-Modulated Radiotherapy for Squamous Cell Carcinoma of the External Auditory Canal and Middle Ear: Treatment Outcomes, Marginal Misses, and Perspective on Target Delineation

    SciTech Connect (OSTI)

    Chen, Wan-Yu [Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan (China); Kuo, Sung-Hsin [Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan (China); Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan (China); Chen, Yu-Hsuan; Lu, Szu-Huai; Tsai, Chiao-Ling [Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan (China); Chia-Hsien Cheng, Jason [Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan (China); Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan (China); Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan (China); Hong, Ruey-Long [Division of Medical Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan (China); Chen, Ya-Fang [Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan (China); Hsu, Chuan-Jen; Lin, Kai-Nan; Ko, Jenq-Yuh; Lou, Pei-Jen; Wang, Cheng-Ping [Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan (China); Chong, Fok-Ching [Graduate Institute of Electrical Engineering, National Taiwan University, Taipei, Taiwan (China); Wang, Chun-Wei, E-mail: cwwang@ntuh.gov.tw [Graduate Institute of Electrical Engineering, National Taiwan University, Taipei, Taiwan (China)

    2012-03-15

    Purpose: To report outcomes of the rare disease of squamous cell carcinoma (SCC) of the external auditory canal (EAC) and middle ear treated with surgery and postoperative intensity-modulated radiotherapy (IMRT). Failure patterns related to spatial dose distribution were also analyzed to provide insight into target delineation. Methods and Materials: A retrospective review was conducted of the records of 11 consecutive patients with SCC of the EAC and middle ear who were treated with curative surgery and postoperative IMRT at one institution between January 2007 and February 2010. The prescribed IMRT dose was 60 to 66 Gy at 2 Gy per fraction. Three patients also received concurrent cisplatin-based chemotherapy, and 1 patient received concurrent oral tegafur/uracil. The median follow-up time was 19 months (range, 6-33 months). Results: Four patients had locoregional recurrence, yielding an estimated 2-year locoregional control rate of 70.7%. Among them, 1 patient had persistent disease after treatment, and 3 had marginal recurrence. Distant metastasis occurred in 1 patient after extensive locoregional recurrence, yielding an estimated 2-year distant control rate of 85.7%. The estimated 2-year overall survival was 67.5%. The three cases of marginal recurrence were near the preauricular space and glenoid fossa of the temporomandibular joint, adjacent to the apex of the ear canal and glenoid fossa of the temporomandibular joint, and in the postauricular subcutaneous area and ipsilateral parotid nodes, respectively. Conclusions: Marginal misses should be recognized to improve target delineation. When treating SCC of the EAC and middle ear, care should be taken to cover the glenoid fossa of the temporomandibular joint and periauricular soft tissue. Elective ipsilateral parotid irradiation should be considered. The treatment planning procedure should also be refined to balance subcutaneous soft-tissue dosimetry and toxicity.

  6. Systems and methods for biometric identification using the acoustic properties of the ear canal

    DOE Patents [OSTI]

    Bouchard, A.M.; Osbourn, G.C.

    1998-07-28

    The present invention teaches systems and methods for verifying or recognizing a person`s identity based on measurements of the acoustic response of the individual`s ear canal. The system comprises an acoustic emission device, which emits an acoustic source signal s(t), designated by a computer, into the ear canal of an individual, and an acoustic response detection device, which detects the acoustic response signal f(t). A computer digitizes the response (detected) signal f(t) and stores the data. Computer-implemented algorithms analyze the response signal f(t) to produce ear-canal feature data. The ear-canal feature data obtained during enrollment is stored on the computer, or some other recording medium, to compare the enrollment data with ear-canal feature data produced in a subsequent access attempt, to determine if the individual has previously been enrolled. The system can also be adapted for remote access applications. 5 figs.

  7. Systems and methods for biometric identification using the acoustic properties of the ear canal

    DOE Patents [OSTI]

    Bouchard, Ann Marie (Albuquerque, NM); Osbourn, Gordon Cecil (Albuquerque, NM)

    1998-01-01

    The present invention teaches systems and methods for verifying or recognizing a person's identity based on measurements of the acoustic response of the individual's ear canal. The system comprises an acoustic emission device, which emits an acoustic source signal s(t), designated by a computer, into the ear canal of an individual, and an acoustic response detection device, which detects the acoustic response signal f(t). A computer digitizes the response (detected) signal f(t) and stores the data. Computer-implemented algorithms analyze the response signal f(t) to produce ear-canal feature data. The ear-canal feature data obtained during enrollment is stored on the computer, or some other recording medium, to compare the enrollment data with ear-canal feature data produced in a subsequent access attempt, to determine if the individual has previously been enrolled. The system can also be adapted for remote access applications.

  8. Use and selection of highway bridges by Rafinesque’s big-eared bats in South Carolina

    E-Print Network [OSTI]

    Bennett, Frances M.

    2005-01-01

    s big-eared bats in South Carolina and also carried out anon all public roads in South Carolina. We surveyed 1,129s big-eared bats in the South Carolina Coastal Plain. Our

  9. Energy Eye | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoopButtePowerEdisto Electric Coop, Inc JumpElko,ServiziEnergyIndex (EDI)EmpowersEye

  10. Middle ear pressure gain and cochlear input impedance in the chinchilla

    E-Print Network [OSTI]

    Slama, Michaël C. C. (Michaël Charles Chalom)

    2008-01-01

    Measurements of middle ear conducted sound pressure in the cochlear vestibule PV have been performed in only a few individuals from a few mammalian species. Simultaneous measurements of sound-induced stapes velocity VS are ...

  11. DSP.Ear: Leveraging Co-Processor Support for Continuous Audio Sensing on Smartphones

    E-Print Network [OSTI]

    Georgiev, Petko; Lane, Nicholas D.; Rachuri, Kiran K.; Mascolo, Cecilia

    2014-01-01

    . However, the cumulative processing burden critically impacts the phone battery. To address this problem, we propose DSP.Ear – an integrated sensing system that takes advantage of the latest low-power DSP co-processor technology in commodity mobile...

  12. EARS: ELECTROMYOGRAPHICAL AUTOMATIC RECOGNITION Szu-Chen Stan Jou and Tanja Schultz

    E-Print Network [OSTI]

    Schultz, Tanja

    EARS: ELECTROMYOGRAPHICAL AUTOMATIC RECOGNITION OF SPEECH Szu-Chen Stan Jou and Tanja Schultz research on automatic speech recognition of surface electromyographic signals that are generated, experiments are conducted to show the anticipatory behavior of electromyographic signals with respect

  13. A Review of Gene Delivery and Stem Cell Based Therapies for Regenerating Inner Ear Hair Cells

    E-Print Network [OSTI]

    Devarajan, Keerthana; Staecker, Hinrich; Detamore, Michael S.

    2011-09-13

    regenerative capacity of the inner ear hair cells. With recent advances in understanding the developmental biology of mammalian and non-mammalian hair cells a variety of strategies have emerged to restore lost hair cells are being developed. Two predominant...

  14. Using otoacoustic emissions to measure the transmission matrix of the middle-ear

    E-Print Network [OSTI]

    Miller, Antonio John

    2006-01-01

    Here we describe an experimental method for measuring the acoustic transmission matrix of the middle-ear using otoacoustic emissions. The experiment builds on previous work that uses distortion product otoacoustic emissions ...

  15. Laser EYE SURGERY LASIK and Excimer Lasers

    E-Print Network [OSTI]

    Hansma, Paul

    Laser EYE SURGERY LASIK and Excimer Lasers Michael Hutchins #12;The PROBLEM opia - near sightedness - Laser Assisted in SItu Keratomileusis atomileusis is the procedure of opening the eye and ring the cornea. SIK uses an excimer laser to perform the alterations an er a knife or a femtosecond laser

  16. Robert E. Marc Moran Eye Center

    E-Print Network [OSTI]

    Marc, Robert E.

    #12;Robert E. Marc Moran Eye Center University of Utah Disclosure REM is a principal of Signature IN RETINAL NEUROANATOMY Marc RE 2010 Synaptic Organization of the retina. Adler's Physiology of the Eye 7(3): e1000074 Marc RE 2009 Functional Anatomy of the Retina. Duane's Foundations of Clinical

  17. BOOK REVIEW: The Naked Eye, by Yoko Tawada

    E-Print Network [OSTI]

    Manthripragada, Ashwin

    2009-01-01

    Y?ko Tawada, The Naked Eye. Trans. Susan Bernofsky. Newparagraph of Y?ko Tawada’s The Naked Eye is a blueprint forapproach to writing The Naked Eye, reading this sound

  18. HotEye® Steel Surface Inspection System

    Broader source: Energy.gov [DOE]

    A new inspection system, the HotEye® Rolled Steel Bar (RSB) System, has been developed and demonstrated by OG Technologies (OGT) Inc., with the help of both a NICE3 grant and a project under the...

  19. Data eye monitor method and apparatus

    DOE Patents [OSTI]

    Gara, Alan G. (Mount Kisco, NY); Marcella, James A. (Rochester, MN); Ohmacht, Martin (Yorktown Heights, NY)

    2012-01-31

    An apparatus and method for providing a data eye monitor. The data eye monitor apparatus utilizes an inverter/latch string circuit and a set of latches to save the data eye for providing an infinite persistent data eye. In operation, incoming read data signals are adjusted in the first stage individually and latched to provide the read data to the requesting unit. The data is also simultaneously fed into a balanced XOR tree to combine the transitions of all incoming read data signals into a single signal. This signal is passed along a delay chain and tapped at constant intervals. The tap points are fed into latches, capturing the transitions at a delay element interval resolution. Using XORs, differences between adjacent taps and therefore transitions are detected. The eye is defined by segments that show no transitions over a series of samples. The eye size and position can be used to readjust the delay of incoming signals and/or to control environment parameters like voltage, clock speed and temperature.

  20. Linear Regression of Eye Velocity on Eye Position and Head Velocity Suggests a Common Oculomotor Neural Integrator

    E-Print Network [OSTI]

    Tank, David

    . The linear regression method presented here is valid for both fixation and low head velocity VOR dataLinear Regression of Eye Velocity on Eye Position and Head Velocity Suggests a Common Oculomotor Aksay, David W. Tank, and H. S. Seung. Linear regression of eye velocity on eye position and head

  1. Eye of the Forehead and Eye of the Mind: How Engineers and Scientists See

    ScienceCinema (OSTI)

    Lienhard, John [NPR, United States

    2010-09-01

    Public radio host Dr. John Lienhard gives a talk titled "Eye of the Forehead and Eye of the Mind: How Engineers and Scientists See". Lienhard contends that spatial visualization is the subtlest of abilities. In his talk, he traces its evolution through the past five centuries and explains how remarkable aids to seeing may have been placing mental visualization under threat.

  2. Optimization of Blank Shape to Minimize Earing in Fully-Drawn

    E-Print Network [OSTI]

    Grujicic, Mica

    elastic--plastic, temperature and rateplastic, temperature and rate dependent crystal plasticity model based on thedependent crystal plasticity model based on the theory of thermallytheory of thermally is Deep Drawing? What is Earing? Crystal Plasticity Model FEM Simulations Results and Discussion #12;Deep

  3. AER EAR: A Matched Silicon Cochlea Pair with Address Event Representation Interface

    E-Print Network [OSTI]

    Liu, Shih-Chii

    AER EAR: A Matched Silicon Cochlea Pair with Address Event Representation Interface André van, the Address Event Representation (AER) interface has become the standard interface protocol in recent years. The AER approach allows us to model biological systems using discrete level (spikes) and continuous

  4. Infrasound, the Ear and Wind Turbines Alec N. Salt, Ph.D.

    E-Print Network [OSTI]

    Salt, Alec N.

    Infrasound, the Ear and Wind Turbines Alec N. Salt, Ph.D. Department of Otolaryngology there happens to be a castle nearby). #12;Wind turbines haveWind turbines have been getting biggerbeen getting MegaWatts(MW) Total Installed Change by year 3% of US Energy Needs Wind turbines are "green" and are

  5. Does the infrasound from wind turbines affect the inner ear? Alec N. Salt1

    E-Print Network [OSTI]

    Salt, Alec N.

    Does the infrasound from wind turbines affect the inner ear? Alec N. Salt1 1 Washington University turbines adversely affects human health. The unweighted spectrum of wind turbine noise slowly rises (needing over 120 dB SPL to detect 2 Hz) it is claimed that infrasound generated by wind turbines is below

  6. Steps for Using the EAR Part 732-page 1 Export Administration Regulations

    E-Print Network [OSTI]

    Bernstein, Daniel

    Steps for Using the EAR Part 732-page 1 Export Administration Regulations §732.1 STEPS OVERVIEW (a requirements such as clearing your export with the U.S. Customs Service, keeping records, and completing and will be of help to you in reviewing these steps: (1) What is it? What an item is, for export control purposes

  7. Intra- and interspecific responses to Rafinesque’s big-eared bat (Corynorhinus rafinesquii) social calls.

    SciTech Connect (OSTI)

    Loeb, Susan, C.; Britzke, Eric, R.

    2010-07-01

    Bats respond to the calls of conspecifics as well as to calls of other species; however, few studies have attempted to quantify these responses or understand the functions of these calls. We tested the response of Rafinesque’s big-eared bats (Corynorhinus rafinesquii) to social calls as a possible method to increase capture success and to understand the function of social calls. We also tested if calls of bats within the range of the previously designated subspecies differed, if the responses of Rafinesque’s big-eared bats varied with geographic origin of the calls, and if other species responded to the calls of C. rafinesquii. We recorded calls of Rafinesque’s big-eared bats at two colony roost sites in South Carolina, USA. Calls were recorded while bats were in the roosts and as they exited. Playback sequences for each site were created by copying typical pulses into the playback file. Two mist nets were placed approximately 50–500 m from known roost sites; the net with the playback equipment served as the Experimental net and the one without the equipment served as the Control net. Call structures differed significantly between the Mountain and Coastal Plains populations with calls from the Mountains being of higher frequency and longer duration. Ten of 11 Rafinesque’s big-eared bats were caught in the Control nets and, 13 of 19 bats of other species were captured at Experimental nets even though overall bat activity did not differ significantly between Control and Experimental nets. Our results suggest that Rafinesque’s big-eared bats are not attracted to conspecifics’ calls and that these calls may act as an intraspecific spacing mechanism during foraging.

  8. Demand Response: Lessons Learned with an Eye to the Future |...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Demand Response: Lessons Learned with an Eye to the Future Demand Response: Lessons Learned with an Eye to the Future July 11, 2013 - 11:56am Addthis Patricia A. Hoffman Patricia...

  9. Publications Texas Reports Eye Seafood Consumers, Recreational

    E-Print Network [OSTI]

    Publications Texas Reports Eye Seafood Consumers, Recreational Facilities, Sport Shrimping, and Marina Management charge from the Center for Marine Re- sources, Texas A&M University, Col- lege Station- terns and Product Perceptions in Texas" (TAMU-SG-75-216) by Samuel M. Gillespie and Michael J. Houston

  10. dlx and sp6-9 Control Optic Cup Regeneration in a Prototypic Eye

    E-Print Network [OSTI]

    Lapan, Sylvain William

    Optic cups are a structural feature of diverse eyes, from simple pit eyes to camera eyes of vertebrates and cephalopods. We used the planarian prototypic eye as a model to study the genetic control of optic cup formation ...

  11. My, What Big Eyes You Have Galileo and

    E-Print Network [OSTI]

    Walter, Frederick M.

    Observatories · Mitigate against light pollution 1908 1988 #12;Other Possibilities SOFIA #12;Other Possibilities serve two main purposes: · To collect light · To provide angular resolution #12;Light Collection - The Eye The eye is a light collecting device · The dark-adapted eye has an aperture of about 0.25 cm2

  12. Sexual dimorphism in wing beat frequency in relation to eye span in stalk-eyed flies (Diopsidae)

    E-Print Network [OSTI]

    Wilkinson, Gerald S.

    Sexual dimorphism in wing beat frequency in relation to eye span in stalk-eyed flies (Diopsidae related to relative eye span in males, and sexual dimorphism in wing beat frequency is negatively related that act to reduce such costs, yet such compensatory traits are often ignored in studies of sexual

  13. A wearable heart monitor at the ear using ballistocardiogram (BCG) and electrocardiogram (ECG) with a nanowatt ECG heartbeat detection circuit

    E-Print Network [OSTI]

    He, David Da

    2013-01-01

    This work presents a wearable heart monitor at the ear that uses the ballistocardiogram (BCG) and the electrocardiogram (ECG) to extract heart rate, stroke volume, and pre-ejection period (PEP) for the application of ...

  14. Defined populations of inner ear progenitor cells show limited and distinct capacities for differentiation into hair cells, neurons, and glia

    E-Print Network [OSTI]

    McLean, Will (Will James)

    2014-01-01

    Despite the fact that mammalian hair cells and neurons do not naturally regenerate in vivo, progenitor cells exist within the postnatal inner ear that can be manipulated to generate hair cells and neurons. This work reveals ...

  15. Taxonomy and evolutionary relationships of Phillips’ small-eared shrew, Cryptotis phillipsii (Schaldach, 1966), from Oaxaca, Mexico (Mammalia: Insectivora: Soricidae)

    E-Print Network [OSTI]

    Woodman, Neal; Timm, Robert M.

    2000-07-01

    The name Cryptotis peregrina (Merriam, 1895) previously encompassed two separate populations of a small-eared shrew of the Cryptotis mexicana group inhabiting the Sierra de Cuatro Venados and the Sierra de Miahuatlán in ...

  16. Vocal development during postnatal growth and ear morphology in a shrew that generates seismic vibrations, Diplomesodon pulchellum

    E-Print Network [OSTI]

    Zaytseva, Alexandra S.; Volodin, Ilya A.; Mason, Matthew J.; Frey, Roland; Fritsch, Guido; Ilchenko, Olga G.; Volodina, Elena V.

    2015-06-04

    The ability of adult and subadult piebald shrews (Diplomesodon pulchellum) to produce 160 Hz seismic waves is potentially reflected in their vocal ontogeny and ear morphology. In this study, the ontogeny of call variables and body traits...

  17. Effect of plant populations and row spacings on plant and ear characters and grain yield of corn hybrids 

    E-Print Network [OSTI]

    Silapapun, Anek

    1976-01-01

    break- age and barren stalks increased with increase in population densities. Allessi and Power (2) also found that number of barren stalks increased and ear weight decreased with increased plant population. Bleasdale (7) proposed that if a crop...EFFECT OF PLANT POPULATIONS AND ROW SPACINGS ON PLANT AND EAR CHARACTERS AND GRAIN YIELD OF CORN HYBRIDS A Thesis by ANEK SILAPAPUN Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement...

  18. Eye Gaze Tracking using Correlation Filters

    SciTech Connect (OSTI)

    Karakaya, Mahmut; Boehnen, Chris Bensing; Bolme, David S; Mahallesi, Mevlana; Kayseri, Talas

    2014-01-01

    In this paper, we studied a method for eye gaze tracking that provide gaze estimation from a standard webcam with a zoom lens and reduce the setup and calibration requirements for new users. Specifically, we have developed a gaze estimation method based on the relative locations of points on the top of the eyelid and eye corners. Gaze estimation method in this paper is based on the distances between top point of the eyelid and eye corner detected by the correlation filters. Advanced correlation filters were found to provide facial landmark detections that are accurate enough to determine the subjects gaze direction up to angle of approximately 4-5 degrees although calibration errors often produce a larger overall shift in the estimates. This is approximately a circle of diameter 2 inches for a screen that is arm s length from the subject. At this accuracy it is possible to figure out what regions of text or images the subject is looking but it falls short of being able to determine which word the subject has looked at.

  19. EyeOn Solar | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoopButtePowerEdisto Electric Coop,Erosion FlumeEvent PlanningBirdsmethodEnergyEyeOn

  20. The distribution and contaminant exposure of Rafinesque's Big-Eared Bats in South Carolina with an emphasis on bridge surveys.

    SciTech Connect (OSTI)

    F.M. Bennett; S.C. Loeb; W.W. Bowerman

    2003-10-23

    Rafinesque's big-eared bat (Corynorhinus rafinesquii), an insectivorous mammal indigenous to the southern United States, has long been referred to as one of the least known bats in North America. Although there has been a moderate increase in the number of peer-reviewed articles published on this species in the past 6 years, the basic ecology and status of Rafinesque's big-eared bat remains largely obscure. Prior to 1996, when the United States Fish and Wildlife Service (USFWS) discontinued the list of Candidate Species, Rafinesque's big-eared bat was listed as a Federal Category 2 Candidate species. Currently, Rafinesque's big-eared bat is recognized as a ''species of special concern'' across most of its range but receives no legal protection. Nonetheless, the USFWS and numerous state agencies remain concerned about this species. Further biological research and field study are needed to resolve the conservation status of this taxona. In response to the paucity of information regarding the status and distribution of Rafinesque's big-eared bat, statewide survey of highway bridges used as roost sites was conducted.

  1. Eye Contact Reminder System for People with Autism

    E-Print Network [OSTI]

    Gnawali, Omprakash

    Eye Contact Reminder System for People with Autism Xi Wang1, Nicholas Desalvo1, Xi Zhao1, Tao Feng1 of Houston1 The Autism Research Laboratory, The University of Texas Health Science Center2 Email: {xiwang--Avoiding eye contact behavior has been character- istic of individuals with autism. Such behavior prevents

  2. Adaptive Evolution of Eye Degeneration in the Mexican Blind Cavefish

    E-Print Network [OSTI]

    Monteiro, Antónia

    Adaptive Evolution of Eye Degeneration in the Mexican Blind Cavefish W. R. JEFFERY Department degeneration in cave-adapted animals have not been resolved. Opposing hypotheses invoking neural mutation-dwelling forms (cavefish), which shed new light on this problem. The manner of eye development and degeneration

  3. Large-scale Scene Understanding Challenge: Eye Tracking Saliency Estimation

    E-Print Network [OSTI]

    Xiao, Jianxiong

    Large-scale Scene Understanding Challenge: Eye Tracking Saliency Estimation Yinda Zhang, Fisher Yu of eye tracking saliency challenge is to generate a saliency map (Fig. 1(c)), which can predict map and unzip them in to a same folder, e.g. Root. The raw images are collected from SUN database [2

  4. IMAGING INTERACTION INNOVATIVE INTERFACES Four Eyes Laboratory 2013 Open House

    E-Print Network [OSTI]

    California at Santa Barbara, University of

    FOUR EYES IMAGING INTERACTION INNOVATIVE INTERFACES Four Eyes Laboratory 2013 Open House Thursday being passive opaque monoliths of bytes to active transparent data structures with automatic management. The hackers posted a fake tweet about an attack on the white house in which president Obama was injured

  5. Automatically Generating Eye Motion in Virtual Agents Eye Motion has a fundamental role in verbal and non-verbal

    E-Print Network [OSTI]

    Animation's applications, such as virtual humans in general and game/movies characters. This paper presents tagging 1. INTRODUCTION Virtual humans have been widely used in many applica- tions. One is concernedAutomatically Generating Eye Motion in Virtual Agents ABSTRACT Eye Motion has a fundamental role

  6. JOURNAL OF MATERIALS SCIENCE 37 (2002) 753 764 Crystal plasticity analysis of earing in deep-drawn

    E-Print Network [OSTI]

    Grujicic, Mica

    2002-01-01

    JOURNAL OF MATERIALS SCIENCE 37 (2002) 753­ 764 Crystal plasticity analysis of earing in deep to derive a crystal-plasticity materials constitutive model for deformation of OFHC copper single crystals that the crystallographic texture in as-rolled sheets, which can be accounted for through the use of crystal-plasticity

  7. Ecological & Environmental Acoustic Remote Sensor (EcoEARS) Application for Long-Term Monitoring and Assessment of Wildlife

    E-Print Network [OSTI]

    Maher, Robert C.

    Ecological & Environmental Acoustic Remote Sensor (EcoEARS) Application for Long-Term Monitoring and Assessment of Wildlife Gonzalo Sanchez; President, Sanchez Industrial Design, Inc., 3510 Beltline Hwy and installation of specialized electronic hardware used to collect both acoustic and environmental data. He holds

  8. Section 21: Drug Discovery/Delivery Pharmacokinetic Considerations of Local Drug Delivery to the Inner Ear by

    E-Print Network [OSTI]

    Salt, Alec N.

    1 Section 21: Drug Discovery/Delivery Pharmacokinetic Considerations of Local Drug Delivery.Plontke@uni-tuebingen.de Although there is increasing interest in the local delivery of drugs to the inner ear by applying them to the round window (RW) membrane, most drug application protocols have been empirically- based. As a result

  9. Adenoviral Mediated Gene Delivery to Human Umbilical Cord Mesenchymal Stromal Cells for Inner Ear Hair Cell Differentiation

    E-Print Network [OSTI]

    Devarajan, Keerthana

    2011-07-28

    . Sensory neural hearing loss (SNHL) is the most common form, which results from degeneration of inner ear sensory hair cells and auditory neurons in the cochlea. In recent years, there has been an increasing interest in gene delivery to mesenchymal stem...

  10. All Eyes on Additive Manufacturing Methods | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    All Eyes on Additive Manufacturing Methods Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new window) Click...

  11. Angiographic Method Using Green Porphyrinew In Primmate Eyes

    DOE Patents [OSTI]

    Miller, Joan W. (Boston, MA); Young, Lucy H.Y. (Boston, MA); Gragoudas, Evangelos S. (Boston, MA)

    1998-01-13

    An angiographic method to observe the condition of blood vessels, including neovasculature in the eyes of living primates using green porphyrins and light at a wavelength of 550-700 nm to effect fluorescence is disclosed.

  12. Visual Feedback in a Coordinated Hand-Eye System

    E-Print Network [OSTI]

    Woodham, Robert J.

    A system is proposed for the development of new techniques for the control and monitoring of a mechanical arm-hand. The use of visual feedback is seen to provide new interactive capabilities in a machine hand-eye system. ...

  13. Artificial Intelligence through the eyes of Organised Sound

    E-Print Network [OSTI]

    Miranda, Eduardo Reck

    Artificial Intelligence through the eyes of Organised Sound Eduardo Miranda Keywords: Artificial Intelligence, symbolic and artificial life approaches, algorithmic composition Abstract Artificial intelligence is a rich and still-developing field with many musical applications

  14. The twitcing eye : REM sleep and the emotional brain

    E-Print Network [OSTI]

    Beck, Taylor McGowin

    2012-01-01

    Sleep and emotion have been linked since the discovery of rapid eye movement (REM) sleep sixty years ago. Sleep, in particular REM sleep and the dreams it harbors, seems to modulate mood, restoring stability to the weary ...

  15. Eye Movements Modulate the Spatiotemporal Dynamics of Word Processing

    E-Print Network [OSTI]

    Temereanca, Simona

    Active reading requires coordination between frequent eye movements (saccades) and short fixations in text. Yet, the impact of saccades on word processing remains unknown, as neuroimaging studies typically employ constant ...

  16. Vanderbilt University Medical Center -Eye Wash Requirements Requirements

    E-Print Network [OSTI]

    Wikswo, John

    Requirements OSHA Refers to the ANSI Standard ANSI is the American National Standards Institute. ANSI Z358 University Medical Center - Eye Wash Requirements General Information from ANSI Eyewash station ANSI 9 of 15 Vanderbi

  17. TAKE-HOME EXP. # 1 Naked-Eye Observations of Stars and Planets

    E-Print Network [OSTI]

    Pickett, Galen T.

    TAKE-HOME EXP. # 1 Naked-Eye Observations of Stars and Planets Naked-eye observations of some few thousand years, what humans have said about the universe based on naked-eye observations and unchanging pattern of lights. Naked eye observations and imagination has led to constellation names like "Big

  18. Sorghum Diseases

    E-Print Network [OSTI]

    Amador, Jose; Berry, Robert W.; Frederiksen, Richard A.; Horne, C. Wendell; Thames, Walter H.; Toler, Robert W.

    1969-01-01

    Foreign animal disease can cause serious damage to the United States (US) agricultural sector and foot-and-mouth disease (FMD), in particular, poses a serious threat. FMD causes death and reduced fecundity in infected ...

  19. Information Regarding MENINGOCOCCAL DISEASE

    E-Print Network [OSTI]

    . Meningococcal disease is a serious disease, caused by bacteria. Meningococcal disease is a contagious

  20. Seasonal and multiannual roost use by Rafinesque's Big-eared Bats in the Coastal Plain of South Carolina.

    SciTech Connect (OSTI)

    Loeb, Susan, C.; Zarnoch, Stanley, J.

    2011-12-01

    Little is known about factors affecting year-round use of roosts by Rafinesque's big-eared bats (Corynorhinus rafinesquii) or the long-term fidelity of this species to anthropogenic or natural roosts. The objectives of this study were to test whether seasonal use of roosts by Rafinesque's big-eared bats varied with roost type and environmental conditions within and among seasons and to document multiannual use of natural and anthropogenic structures by this species. We inspected 4 bridges, 1 building, and 59 tree roosts possessing basal cavity openings; roosts were inspected at least once per week from May through October in every year from 2005 through 2008 and once a month from November through April in every year from 2005 through 2009. We found that use of anthropogenic roosts was significantly greater than the use of tree roosts in summer but that the use of structure types did not differ in other seasons. There was significant seasonal variation in use of anthropogenic and tree roosts. Anthropogenic roost use was higher in summer than in all other seasons. There was no significant difference in tree use among spring, summer, and fall, but use in winter was significantly lower in 2 years of the study. Overall use of anthropogenic and tree roosts was positively related to minimum temperature, but the relationship between use of roosts and minimum temperature varied among seasons. Bats showed multiannual fidelity ({ge} 4 years) to all anthropogenic roosts and to some tree roosts, but fidelity of bats to anthropogenic roosts was greater and more consistent than to tree roosts. Our data indicate that Rafinesque's big-eared bats responded differently to environmental conditions among seasons; thus, a variety of structure types and characteristics are necessary for conservation of these bats. We suggest long-term protection of roost structures of all types is necessary for conservation of Rafinesque's big-eared bats in the southeast Coastal Plain.

  1. Seems a Fate in It: Misdirection and Foreshadowing in Bleak House and A Pair of Blue Eyes

    E-Print Network [OSTI]

    Bradfield, Meredith

    2013-01-01

    for Action in A Pair of Blue Eyes. ” English Literature in2013). Hardy, Thomas. A Pair of Blue Eyes. Harmondsworth,aware of Thomas Hardy. A Pair of Blue Eyes. (Harmondsworth,

  2. Archaeological evidence for ship eyes: an analysis of their form and function 

    E-Print Network [OSTI]

    Nowak, Troy Joseph

    2007-09-17

    During the late 19th century, a number of large marble eyes were discovered near the Athenian naval facilities at Zea. Although initially published as the eyes of ancient Greek warships, many scholars have doubted the ...

  3. U.S. Virgin Islands Ramping Up Clean Energy Efforts with an Eye...

    Energy Savers [EERE]

    U.S. Virgin Islands Ramping Up Clean Energy Efforts with an Eye Toward a Sustainable Future U.S. Virgin Islands Ramping Up Clean Energy Efforts with an Eye Toward a Sustainable...

  4. Modelling search for people in 900 scenes: A combined source model of eye guidance

    E-Print Network [OSTI]

    Ehinger, Krista A.

    How predictable are human eye movements during search in real world scenes? We recorded 14 observers’ eye movements as they performed a search task (person detection) in 912 outdoor scenes. Observers were highly consistent ...

  5. Design of an improved electronics platform for the EyeRing wearable device

    E-Print Network [OSTI]

    Ran, Kelly (Kelly A.)

    2014-01-01

    This thesis presents a new prototype for EyeRing, a finger-worn device equipped with a camera and other peripherals. EyeRing is used in assistive technology applications, helping visually impaired people interact with ...

  6. The Science of Hurricanes Typical eye diameter ~20 miles

    E-Print Network [OSTI]

    Miami, University of

    #12;The Science of Hurricanes #12;#12;Typical eye diameter ~20 miles Typical hurricane diameter-View of a Hurricane #12;Day 0, Disturbance Day 1, 35mph Depression Day 2, 46mph Tropical Storm Day 3, 63mph Tropical Storm Day 4, 92mph Hurricane Day 5, 127mph Hurricane Day 6, 150mph Hurricane Day 7, 144mph Hurricane Day

  7. Telescopes: Portals of Discovery How does your eye form an

    E-Print Network [OSTI]

    Crenshaw, Michael

    to see through) ­ Dark (far from city lights) ­ Dry (few cloudy nights) #12;7 Light Pollution · Refraction is the bending of light when it passes from one substance into another · Your eye uses refraction to focus light Focusing Light · Refraction can cause parallel light rays to converge to a focus #12;2 Image

  8. Rice Diseases

    E-Print Network [OSTI]

    Jones, Roger K.

    1987-01-01

    Alzheimer's disease (AD) is the most common form of the dementia in the aging population. ?-amyloid peptide (A?) has been indicated as the most important hallmark of AD and also is believed to be the central trigger of ...

  9. Role of Eye, Head, and Shoulder Geometry in the Planning of Accurate Arm Movements

    E-Print Network [OSTI]

    Henriques, Denise Y. P.

    Role of Eye, Head, and Shoulder Geometry in the Planning of Accurate Arm Movements D.Y.P. HENRIQUES and shoulder geometry in the planning of accurate arm movements. J Neurophysiol 87: 1677­1685, 2002; 10.1152/jn with the continuous changes in eye, head, and arm positions. This is a geometrically complex process because the eyes

  10. "Hands Busy, Eyes Busy": Generating Stories from Sensor Data for Automotive applications

    E-Print Network [OSTI]

    Reiter, Ehud

    "Hands Busy, Eyes Busy": Generating Stories from Sensor Data for Automotive applications Joe to support "hands busy, eyes busy" automotive applications. It outlines a hierarchy of complexity of output, eyes busy" automotive ap- plications. Of particular interest is a review of how technolo- gies

  11. Neuropsychologia 43 (2005) 784796 Deficits in saccadic eye-movement control in Parkinson's disease

    E-Print Network [OSTI]

    Munoz, Douglas Perry

    2005-01-01

    ; FP, fixation point; LED, light-emitting diode; MPTP, methyl phenyl tetrahydropyridine; PD, Parkinson

  12. Beryllium disease

    SciTech Connect (OSTI)

    Not Available

    1991-12-20

    After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

  13. 48 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS--I: REGULAR PAPERS, VOL. 54, NO. 1, JANUARY 2007 AER EAR: A Matched Silicon Cochlea Pair With

    E-Print Network [OSTI]

    Liu, Shih-Chii

    48 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS--I: REGULAR PAPERS, VOL. 54, NO. 1, JANUARY 2007 AER- dress event representation (AER) EAR. The chip was fabricated in a 3-metal 2-poly 0.5- m CMOS process. I. INTRODUCTION FOR multi-chip neuromorphic systems, the address event representation (AER

  14. 14 February 2005/Vol. 48, No. 2 COMMUNICATIONS OF THE ACM earing the end of a talk I gave at Google

    E-Print Network [OSTI]

    California at Berkeley, University of

    14 February 2005/Vol. 48, No. 2 COMMUNICATIONS OF THE ACM N earing the end of a talk I gave at Google recently, I turned to the subject of becom- ing a member of ACM. I've come to real- ize that some, I've concluded that joining ACM is wise regardless of your perspective: membership supports many

  15. Sleepy Eye Public Utility Comm | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop Inc JumpHeter Battery Technology CoWanpingSilveira deScienceSky EnergySkyFuelEye

  16. Autism, Eye-Tracking, Entropy Frederick Shic, Katarzyna Chawarska, Jessica Bradshaw, Brian Scassellati

    E-Print Network [OSTI]

    Scassellati, Brian

    Autism, Eye-Tracking, Entropy Frederick Shic, Katarzyna Chawarska, Jessica Bradshaw, Brian of 2 year old and 4 year old toddlers with and without autism spectrum disorder as they view static. Keywords- autism; eye-tracking; entropy; Markov; faces I. INTRODUCTION Autism is a pervasive developmental

  17. A ber-optic based calibration system for the High Resolution Fly's Eye

    E-Print Network [OSTI]

    A ber-optic based calibration system for the High Resolution Fly's Eye cosmic ray observatory J, 800 Yale Blvd NE, Albuquerque, NM 87131-1156 Abstract This article describes the ber-optic based: Highest energy cosmic rays Fly's Eye Experiment HiRes YAG Laser Fiber-optics PMT PACS: 95.45.+i 95.85.Ls

  18. God's Left Eye Closes in Vietnam And Re-Opens in California

    E-Print Network [OSTI]

    Zordan, Victor

    God's Left Eye Closes in Vietnam And Re-Opens in California Caodaism's Transpacific Transformations Caodaism is a new religion revealed to a group of colonized intellectuals in southern Vietnam in 1926 who documentaries (distributed by www.der.org), including "The Left Eye of God: Caodaism Travels from Vietnam

  19. Perception of static eye gaze direction facilitates subsequent early visual processing

    E-Print Network [OSTI]

    Rossion, Bruno

    Perception of static eye gaze direction facilitates subsequent early visual processing Anne similar early sensory modulations are also elicited by static gaze cues, or if previously described in the right hemisphere. Conclusions: Spatial attention triggered by static eye gaze direction produces

  20. Optical properties of the mouse eye Ying Geng,1,2,*

    E-Print Network [OSTI]

    Optical properties of the mouse eye Ying Geng,1,2,* Lee Anne Schery,1 Robin Sharma,1,2 Alfredo, University of Rochester, Rochester, NY, 14627, USA 2 The Institute of Optics, University of Rochester indicate that the optical quality of the mouse eye assessed by measurement of its aberrations is remarkably

  1. Abstract--Eye blinking artifacts present serious problems for electroencephalographic (EEG) interpretation and analysis. In

    E-Print Network [OSTI]

    Slatton, Clint

    interpretation and analysis. I. INTRODUCTION lectroencephalographic (EEG) recordings are usually contaminated) interpretation and analysis. In this study, we apply independent component analysis (ICA) to eye blinking artifact removal from cognitive EEG recordings. Due to the specific design of the experiment, the eye

  2. A Neural Computation for Visual Acuity in the Presence of Eye Movements

    E-Print Network [OSTI]

    the complex eye movement trajectory, then it could realign the retinal responses before processing them must identify the retinal firing patterns induced by the stimulus while discounting similar patterns caused by spontaneous retinal activity. This is a challenge since the trajectory of the eye movements

  3. Search for high-energy muon neutrinos from the "naked-eye" GRB080319B with the IceCube neutrino telescope

    E-Print Network [OSTI]

    Abbasi, R.; IceCube Collaboration

    2009-01-01

    muon neutrinos from the “naked-eye” GRB 080319B with themuon neutrinos from the “naked-eye” GRB080319B with theof 5.3 even visible to the naked eye for a short period of

  4. Fabrication of moth-eye structures on silicon by direct six-beam laser interference lithography

    SciTech Connect (OSTI)

    Xu, Jia; Zhang, Ziang; Weng, Zhankun; Wang, Zuobin Wang, Dapeng

    2014-05-28

    This paper presents a new method for the generation of cross-scale laser interference patterns and the fabrication of moth-eye structures on silicon. In the method, moth-eye structures were produced on a surface of silicon wafer using direct six-beam laser interference lithography to improve the antireflection performance of the material surface. The periodic dot arrays of the moth-eye structures were formed due to the ablation of the irradiance distribution of interference patterns on the wafer surface. The shape, size, and distribution of the moth-eye structures can be adjusted by controlling the wavelength, incidence angles, and exposure doses in a direct six-beam laser interference lithography setup. The theoretical and experimental results have shown that direct six-beam laser interference lithography can provide a way to fabricate cross-scale moth-eye structures for antireflection applications.

  5. The Fly's Eye project: sidereal tracking on a hexapod mount

    E-Print Network [OSTI]

    Vida, Krisztián; Mészáros, László; Csépány, Gergely; Jaskó, Attila; Mez?, György; Oláh, Katalin

    2014-01-01

    The driving objective of the Fly's Eye Project is a high resolution, high coverage time-domain survey in multiple optical passbands: our goal is to cover the entire visible sky above the 30 deg horizontal altitude with a cadence of 3 min. Imaging is intended to perform with 19 wide-field cameras mounted on a hexapod platform. The essence of the hexapod allows us to build an instrument that does not require any kind of precise alignment and, in addition, the similar mechanics can be involved independently from the geographical location of the device. Here we summarize our early results with a single camera, focusing on the sidereal tracking as it is performed with the hexapod built by our group.

  6. A Test of the Neuro-linguistic Programming Hypothesis that Eye-Movements Signal Lie and Truth Telling 

    E-Print Network [OSTI]

    Couper, Sara-Louise

    2011-06-29

    This study investigated the claim of Neuro-Linguistic Programming (NLP) practitioners that eye movements to the upper right (UR) indicate a person is lying and eye movements to the upper left (UL) indicate a person is ...

  7. Patterns of avian diversification in Borneo: The case of the endemic Mountain Black-eye (Chlorocharis emiliae)

    E-Print Network [OSTI]

    Gawin, Dency F.; Rahman, Mustafa Abdul; Ramji, Mohamad Fizl Sidq; Smith, Brian Tilston; Lim, Haw Chuan; Moyle, Robert G.; Sheldon, Frederick H.

    2014-01-01

    The Mountain Black-eye (Chlorocharis emiliae) is an endemic white-eye (Zosteropidae) of Borneo with a unique “sky island” distribution. We compared mitochondrial ND2, ND3, Cytb, and control region DNA sequences (2,194 ...

  8. Executive Functions: Eye Movements and Neuropsychiatric A B Sereno, S L Babin, A J Hood, and C B Jeter,

    E-Print Network [OSTI]

    Sereno, Anne B.

    Executive Functions: Eye Movements and Neuropsychiatric Disorders A B Sereno, S L Babin, A J Hood functions. Executive functions influence social, emo- tional, intellectual, and organizational aspects, such disruptions occur in many human disorders. Eye Movements and Executive Functions Eye movements are any shift

  9. Naked-eye optical flash from gamma-ray burst 080319B: Tracing the decaying neutrons in the outflow

    E-Print Network [OSTI]

    Zhang, Bing

    Naked-eye optical flash from gamma-ray burst 080319B: Tracing the decaying neutrons in the outflow/optical emission. The naked-eye optical flash from GRB 080319B, an energetic explosion in the distant Universe, can with the naked eye [1]. For a redshift z ¼ 0:937, the detected peak optical emission had a visual magnitude $5

  10. A Maxwell's fish eye lens for the terahertz region Jingbo Liu, Rajind Mendis, and Daniel M. Mittleman

    E-Print Network [OSTI]

    Natelson, Douglas

    A Maxwell's fish eye lens for the terahertz region Jingbo Liu, Rajind Mendis, and Daniel M://apl.aip.org/features/most_downloaded Information for Authors: http://apl.aip.org/authors #12;A Maxwell's fish eye lens for the terahertz region; published online 15 July 2013) We implement a two-dimensional Maxwell's fish eye lens using a waveguide

  11. Gaucher Disease Inherited disorder

    E-Print Network [OSTI]

    Brutlag, Doug

    , spleen, and bone marrow ¡ Many types ¡ Possible link to Parkinson's Disease ¡ Affects 1 in 100,000 #12/> ¡ "Gaucher Disease." Genetics Home Reference ­ Your Guide to Understanding Genetic Conditions. US National Disease." Gene Review. Web 2 Oct. 2012. Genetics

  12. University of Calgary Eyes High Doctoral Scholarship Biomedical Engineering / Kinesiology / Medical Research in

    E-Print Network [OSTI]

    Calgary, University of

    biomedical engineering research methods, including biomechanics, biochemistry, and biophysical toolsUniversity of Calgary Eyes High Doctoral Scholarship Biomedical Engineering / Kinesiology / Medical, and other ocular conditions. Applicants must have an M.Sc. in biomedical engineering, kinesiology, medical

  13. Stability, unfolding, and aggregation of the gamma D and gamma S human eye lens crystallins

    E-Print Network [OSTI]

    Mills-Henry, Ishara Amenti Rakem

    2007-01-01

    The transparency of the human eye lens depends on the properties of the a- crystallin and py-crystallin families of proteins, which accumulate to very high concentrations in mature lens fiber cells. The 0- and y-crystallins ...

  14. The effects of motion experience on reflexive eye movements and dynamic tilt perception

    E-Print Network [OSTI]

    Ocampo, Robert P. (Robert Paul)

    2008-01-01

    Measured differences between human and primate VOR may derive from disparate experiences with psychophysical motion stimuli. To test this hypothesis, horizontal and torsional eye movements, as well as roll tilt perception, ...

  15. Analysis of the Black-capped Vireo and White-eyed Vireo Nest Predator assemblages 

    E-Print Network [OSTI]

    Conkling, Tara J.

    2011-08-08

    Predation is the leading cause of nest failure in songbirds. My study identified nest predators of black-capped vireos and white-eyed vireos, quantified the activity of potential predator species, examined the relationships between vegetation...

  16. Widespread Presaccadic Recruitment of Neck Muscles by Stimulation of the Primate Frontal Eye Fields

    E-Print Network [OSTI]

    Corneil, Brian D.

    -head gaze shifts by recording EMG activity from multiple dorsal neck muscles after electrical stimulation parsimonious interpretation is that a gaze command issued by the FEF is decomposed into eye and head commands

  17. Removal of eye activity artifacts from visual event-related potentials in normal and clinical subjects

    E-Print Network [OSTI]

    Makeig, Scott

    Objectives: Electrical potentials produced by blinks and eye movements present serious problems for electroencephalographic (EEG) and event-related potential (ERP) data interpretation and analysis, particularly scalp channels. A generally applicable adaptive method for removing artifacts from EEG records based

  18. Proton dose assessment to the human eye using Monte Carlo n-particle transport code (MCNPX) 

    E-Print Network [OSTI]

    Oertli, David Bernhardt

    2009-05-15

    The objective of this project was to develop a simple MCNPX model of the human eye to approximate dose delivered from proton therapy. The calculated dose included that due to proton interactions and secondary interactions, ...

  19. he outermost layer of the human eye--the cornea, see Figure 1--is of

    E-Print Network [OSTI]

    van Vliet, Lucas J.

    so by using the eye to mirror a pattern. Figure 2a shows the cross section of such an in- strument.1 that could integrate real-time solutions to both problems. A D A P T I V E S U R F A C E M E A S U R E M E N, AND HENRI BAL Vrije University 1521-9615/02/$17.00 © 2002 IEEE Figure 1. Cross section of the human eye

  20. Design of 3D eye-safe middle range vibrometer

    SciTech Connect (OSTI)

    Polulyakh, Valeriy; Poutivski, Iouri

    2014-05-27

    Laser Doppler Vibrometer and Range Meter (3D-MRV) is designed for middle range distances [1–100 meters]. 3D-MRV combines more than one laser in one device for a simultaneous real time measuring the distance and movement of the targets. The first laser has a short pulse (t?30psec) and low energy (E?200nJ) for distance measurement and the second one is a CW (continuous wave) single frequency laser for the velocity measurement with output power (P?30mW). Both lasers perform on the eye-safe wavelength 1.5 ?m. 3D-MRV uses the same mono-static optical transmitting and receiving channel for both lasers including an output telescope and a scanning angular system. 3D-MRV has an optical polarization switch to combine linear polarized laser beams from two lasers into one optical channel. The laser beams from both lasers by turns illuminate the target and the scattered laser radiation is collected by the telescope on a photo detector. The electrical signal from photo detector is used for measuring the distance to the target and its movement. For distance measurement the time of flight method is employed. For targets movement the optical heterodyne method is employed. The received CW laser radiation is mixed on a photo detector with the frequency-shifted laser radiation that is taken from CW laser and passed through an acousto-optic cell. The electrical signal from a photo detector on the difference frequency and phase has information about movement of the scattered targets. 3D-MVR may be used for the real time picturing of vibration of the extensive targets like bridges or aircrafts.

  1. QER- Comment of EAR

    Broader source: Energy.gov [DOE]

    I would first like to say that the North East does not have an energy supply problem. The problem that we have is a demand/supply issue. If the problem is only referred to as a supply problem then only supply solutions will be looked at. When we talk about meeting our energy needs the order should be: 1st Conservation 2nd Energy Efficiency …..and if we have a concern about Climate Change 3rd Renewables 4th Polluting technologies such as Fossil Fuels and Nuclear If we do not implement this list in the above order we will leave a very different climate and a planet that is difficult to live on for our children. Conservation, Efficiency and Renewables have been mentioned by a few of the presenters today. We need to bring Conservation, Efficiency and Renewables to center stage to solve our energy needs. Recommendations: Institute to a greater extent "Peak Load Shaving". Make it mandatory that all buildings that are built are Zero Net Energy or Zero Plus Energy. Institute a more aggressive "Time of Use" Electric and Gas Metering System that Mr Reilly of the Vermont Electric Power Company mentioned earlier. Put a severe Carbon Tax on all polluting Energy Producers. Measure CO2 emissions for the complete cycle of extraction, transportation, storage and burning of all Energy options. Remove all incentives and support for Energy Producers of Fossil Fuel and Nuclear.

  2. Interim Chronic Beryllium Disease

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-12-08

    Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

  3. Understanding Heart Disease

    E-Print Network [OSTI]

    Shen, Jun

    1 Understanding Heart Disease Vietnamese Aspire For Healthy Hearts What Is Heart Disease? Heart the blood vessels going to the heart become narrow and clogged. Blood vessels are long, hollow tubes arteries. When arteries become clogged, it increases the risk of developing heart disease. When the heart

  4. Naked eye star visibility and limiting magnitude mapped from DMSP-OLS satellite data

    E-Print Network [OSTI]

    P. Cinzano; F. Falchi; C. D. Elvidge

    2000-11-16

    We extend the method introduced by Cinzano et al. (2000a) to map the artificial sky brightness in large territories from DMSP satellite data, in order to map the naked eye star visibility and telescopic limiting magnitudes. For these purposes we take into account the altitude of each land area from GTOPO30 world elevation data, the natural sky brightness in the chosen sky direction, based on Garstang modelling, the eye capability with naked eye or a telescope, based on the Schaefer (1990) and Garstang (2000b) approach, and the stellar extinction in the visual photometric band. For near zenith sky directions we also take into account screening by terrain elevation. Maps of naked eye star visibility and telescopic limiting magnitudes are useful to quantify the capability of the population to perceive our Universe, to evaluate the future evolution, to make cross correlations with statistical parameters and to recognize areas where astronomical observations or popularisation can still acceptably be made. We present, as an application, maps of naked eye star visibility and total sky brightness in V band in Europe at the zenith with a resolution of approximately 1 km.

  5. Experimentally Induced Retinal Projections to the Ferret Auditory Thalamus: Development of Clustered Eye-Specific Patterns in a

    E-Print Network [OSTI]

    Sur, Mriganka

    and cellular differentiation. Key words: retinogeniculate; eye-specific segregation; chol- era toxin subunit B; medial geniculate nucleus; afferents; cross- modal plasticity A fundamental feature of the development

  6. rhodopsin-like photopigment in adult eyes preserved by rapid freezing suggests that the rhabdoms of B. thermydron beyond the

    E-Print Network [OSTI]

    Quirk, Gregory J.

    rhodopsin-like photopigment in adult eyes preserved by rapid freezing suggests that the rhabdoms for anatomical analysis. Rapid freezing of crabs collected remotely under low light conditions at infrequently being used. Adult eyes were dissected out, quick-frozen using cryogenic spray, and sectioned at 14 mm

  7. {jhkim, btzhang}@bi.snu.ac.kr Eye Movement Analysis for Long-term Memory on Video Stimuli

    E-Print Network [OSTI]

    . Rayner, "Eye Movements in Reading and Information Processing: 20 Years of Research," Psychological Bulletin, vol. 124, no. 3, pp. 372­422, 1998. [2] E. D. Reichle, A. Pollatsek, D. L. Fisher, and K. Rayner. 125­157, 1998. [3] A. W. Inhoff and K. Rayner, "Parafoveal word processing during eye fixations

  8. Our Star, The Sun Looking up at the sky with the naked eye, the Sun seems static, constant. It provides the warmth and light that

    E-Print Network [OSTI]

    Christian, Eric

    #12;Our Star, The Sun Looking up at the sky with the naked eye, the Sun seems static, constant's surface, the corona is only visible to the naked eye during a total solar eclipse. Complicated magnetic

  9. Our Star, The Sun Looking up at the sky with the naked eye, the Sun seems static, constant. It provides the warmth and light that

    E-Print Network [OSTI]

    Christian, Eric

    #12;Our Star, The Sun Looking up at the sky with the naked eye, the Sun seems static, constant into space. Thin and faint com- pared to the Sun's surface, the corona is only visible to the naked eye

  10. Classification of Visual and Linguistic Tasks using Eye-movement Features

    E-Print Network [OSTI]

    Keller, Frank

    . A recent study by Greene, Liu, and Wolfe (2012), however, fails to achieve accurate classification such as language processing. We extract the eye-movement features used by Greene et. al., as well as additional the visual system in ecologically valid real-world tasks, such as making a tea or washing hands; sport activ

  11. Fourier-domain holographic optical coherence imaging of tumor spheroids and mouse eye

    E-Print Network [OSTI]

    Nolte, David D.

    Fourier-domain holographic optical coherence imaging of tumor spheroids and mouse eye Kwan Jeong, Leilei Peng, John J. Turek, Michael R. Melloch, and David D. Nolte Fourier-domain holography (FDH) has the hologram in the Fourier plane significantly reduces background arising from reference light scattered from

  12. The development of the digestive tract and eye in larval walleye pollock,

    E-Print Network [OSTI]

    722 The development of the digestive tract and eye in larval walleye pollock, Theragra chalcogramma the early larval period, two of the most im- portant for walleye pollock may be vision and the digestive). Digestive tract de- velopment is important for efficient assimilation of nutrients needed for growth

  13. Task-Dependent Constraints in Motor Control: Pinhole Goggles Make the Head Move Like an Eye

    E-Print Network [OSTI]

    Henriques, Denise Y. P.

    normally adopts just one torsional angle for any one facing direction (Straumann et al., 1991; Glenn. Ceylan,1,2 D. Y. P. Henriques,1,2 D. B. Tweed,1,3 and J. D. Crawford1,2 1Medical Research Council Group- dimensional eye orientation is used for each gaze direction. Listing's law further specifies that the full set

  14. Mental Imagery in Problem Solving: An Eye Tracking Study Daesub Yoon and N. Hari Narayanan

    E-Print Network [OSTI]

    Narayanan, N. Hari

    Mental Imagery in Problem Solving: An Eye Tracking Study Daesub Yoon and N. Hari Narayanan and empirical studies of problem solving in visuo-spatial and causal domains suggest that problem solving tasks Interface [Vertegaal 2002]. In this paper, we briefly review research related to problem solving

  15. Laser Users Eye Test Form University of Cambridge Laser Users Information for Occupational Health

    E-Print Network [OSTI]

    Cambridge, University of

    Laser Users Eye Test Form University of Cambridge Laser Users Information for Occupational Health supervisor or research group Department College Departmental Laser Safety Officer Tel: Information about the laser(s) you will be using Type of Laser Wavelength Laser Classification CW or Pulsed Power or Energy

  16. MobiEyes: Distributed Processing of Continuously Moving Queries on Moving Objects in a Mobile System

    E-Print Network [OSTI]

    Liu, Ling

    MobiEyes: Distributed Processing of Continuously Moving Queries on Moving Objects in a Mobile. Significant research efforts have been dedicated to techniques for efficient processing of spatial continuous and scalable solution to processing continuously moving queries on moving objects and describe the design

  17. Steering with Eyes Closed: mm-Wave Beam Steering without In-Band Measurement

    E-Print Network [OSTI]

    Knightly, Edward W.

    Steering with Eyes Closed: mm-Wave Beam Steering without In-Band Measurement Thomas Nitsche that removes in-band overhead for directional mm-Wave link establishment. Our sys- tem architecture couples mm-Wave and legacy 2.4/5 GHz bands using out-of-band direction inference to establish (overhead-free) multi-Gbps mm

  18. Combining user logging with eye tracking for interactive and dynamic applications

    E-Print Network [OSTI]

    Çöltekin, Arzu

    , and these interactions cause changes in the extent and/or level of detail of the stimulus. Therefore, in eye tracking the point of regard, or POR) is typically expressed using screen coordinates in pixels. From these basic, including software engineering, industrial en- gineering (e.g., driving, aviation), marketing (e.g., ad

  19. P l e a s e P o s t Instant Adhesive Eye Injury

    E-Print Network [OSTI]

    P l e a s e P o s t Instant Adhesive Eye Injury Lawrence Berkeley National Laboratory Lessons Learned LL-2006-01 Concern Statement: While attempting to apply instant adhesive to a piece with cyanoacrylate instant adhesives. Trade names include 495 Super Bonder® Instant Adhesive, Superglue® , and Krazy

  20. Folding, stability and aggregation of the long-lived eye lens protein human gamma D crystallin

    E-Print Network [OSTI]

    Flaugh, Shannon L

    2006-01-01

    Human [gamma]D crystallin (H[gamma]D-Crys) is a monomeric, two domain, primarily P-sheet protein found in high concentrations in the human eye lens. H[gamma]D-Crys and other crystallins are found in insoluble protein ...

  1. Eye of the beholder: Inside this experimental camera, a stretchable sensor

    E-Print Network [OSTI]

    Rogers, John A.

    Videos Wind Turbine Condition Monitoring Due to environmental conditions, the remoteEye of the beholder: Inside this experimental camera, a stretchable sensor array sits below is a camera, modeled after an eyeball, that features a curved array of light sensors. Now a new design gives

  2. Friday February 20, 2004 Three compromise plans eyed for fusion project site

    E-Print Network [OSTI]

    Friday February 20, 2004 Three compromise plans eyed for fusion project site A team of experts on an international nuclear fusion project has drawn up three compromise proposals in a bid to resolve the row over said. The six parties involved in the Thermonuclear Experimental Reactor (ITER) project have been

  3. Thursday, February 19, 2004 3 compromise plans eyed for nuke fusion site

    E-Print Network [OSTI]

    Thursday, February 19, 2004 3 compromise plans eyed for nuke fusion site TOKYO -- A team of experts on an international nuclear fusion project has drawn up three compromise proposals in a bid to resolve the row over said Wednesday. Thursday, February 19, 2004 at 02:43 JST The six parties involved in the Thermonuclear

  4. Through Kady's Eyes Written by Sandi Rice, Utah Schools for the Deaf and the Blind, Consultant

    E-Print Network [OSTI]

    Huang, Jianyu

    , and downloaded the Aliens Game she would play on my lap top. I held the computer on its side near her face. Within minutes, she was shooting down aliens by exploding them on visual contact, engaging in a computer minutes at a time. But, this time, right away her eyes opened widely and she was looking at the aliens

  5. RemoteEyes: A Remote Low-Cost Position Sensing Infrastructure for Ubiquitous Computing

    E-Print Network [OSTI]

    British Columbia, University of

    RemoteEyes: A Remote Low-Cost Position Sensing Infrastructure for Ubiquitous Computing Changsong infrastructure for ubiquitous computing. To reduce the cost, each tracked object carries an inexpensive active, sensing, network, FPGA, ubiquitous computing INTRODUCTION Context information is required by many

  6. Decorrelation of retinal response to natural scenes by fixational eye movements

    E-Print Network [OSTI]

    Rucci, Michele

    to reduce correlations in retinal responses and contribute to visual information processing. retinaDecorrelation of retinal response to natural scenes by fixational eye movements Irina Yonit Segala. It is commonly assumed that the retina processes this input signal efficiently by taking into account

  7. Towards building an anatomically correct solid eye model with volumetric representation of retinal morphology

    E-Print Network [OSTI]

    Hamann, Bernd

    Towards building an anatomically correct solid eye model with volumetric representation of retinal volumetric retinal morphology) has many applications in the field of ophthalmology, including evaluation of ophthalmic instruments and optometry/ophthalmology training. We present a method that uses volumetric OCT

  8. A Comparison of Hurricane Eye Determination Using Standard and Ultra-High Resolution

    E-Print Network [OSTI]

    Long, David G.

    A Comparison of Hurricane Eye Determination Using Standard and Ultra-High Resolution QuikSCAT Winds of hurricanes. I. INTRODUCTION Space-borne scatterometers such as SeaWinds on QuikSCAT are instruments designed these is the observation and tracking of tropical cyclones including hurricanes. Several fea- tures of interest

  9. Pars Plana Vitrectomy in Eyes Containing a Treated Posterior Uveal Melanoma

    E-Print Network [OSTI]

    Foster, William

    PURPOSE: To determine the safety of pars plana vitrec- tomy in eyes containing a treated posterior uveal mela- noma. DESIGN: Interventional case series. METHODS: Retrospective case series of patients- mor control, and metastasis were assessed. RESULTS: Nine patients met study criteria. Tumors were

  10. ENERGY CALIBRATION OF THE FLY'S EYE DETECTOR Baltrusaitis, R.M., Cassiday, G.L., Cooper, R., Elbert, J.W.,

    E-Print Network [OSTI]

    of photons incident upon the Fly's Eye detector requires a knowledge of the overall efficiency-gain product

  11. Wheat Diseases Atlas. 

    E-Print Network [OSTI]

    McCoy, Norman L.; Berry, Robert W.

    1982-01-01

    to wheat producers over the state on whose farms demonstrations have been conducted and pic tures for this publication were made. WhEAT DisEASES ATLAs Norman L. McCoy and Robert W Berry* INTRODUCTION Wheat diseases have caused untold human suffer ing...

  12. TurkerGaze: Crowdsourcing Saliency with Webcam based Eye Tracking Pingmei Xu Krista A. Ehinger Yinda Zhang Adam Finkelstein Sanjeev R. Kulkarni Jianxiong Xiao

    E-Print Network [OSTI]

    Xiao, Jianxiong

    . Overlapping with top percents of saliency map. Eye tracking saliency on SUN database: 9000 images (expectedTurkerGaze: Crowdsourcing Saliency with Webcam based Eye Tracking Pingmei Xu Krista A. Ehinger http://isun.cs.princeton.edu VISI N GROUP 1. Traditional eye tracking requires special hardware. 2

  13. Adventures in Infectious Diseases

    ScienceCinema (OSTI)

    Fisher-Hoch, Susan [University of Texas School of Public Health

    2014-06-25

    Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

  14. Chronic obstructive pulmonary disease, pulmonary function and cardiovascular disease 

    E-Print Network [OSTI]

    McAllister, David Anthony

    2011-07-05

    Cardiovascular disease is common in Chronic Obstructive Pulmonary Disease (COPD), and forced expiratory volume in one second (FEV1) independently predicts cardiovascular morbidity and mortality. Pathological changes in ...

  15. Osteocytes and Bone Diseases 

    E-Print Network [OSTI]

    Ren, Yinshi

    2015-05-06

    For many centuries, the osteoblast is considered to be responsible for bone formation. It is also believed that an imbalance of osteoblasts (weak) and osteoclasts (strong) is the main cause for bone diseases such as ...

  16. Health & Medicine Heart Disease

    E-Print Network [OSTI]

    Rogers, John A.

    See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

  17. Soybean Diseases Atlas. 

    E-Print Network [OSTI]

    Anonymous,

    1979-01-01

    new disease which causes root and stem rot to soybeans and other legumes in several southern states. The earliest sympt om is yellowing of leaves of individual plants or patches of plants across fields. Leaves of damaged plants usually develop... new soybean disease restricts root development and causes an absence of nitrogen-fixing nodules. Plants are stunted in an irregular pattern that may resemble manganese toxicity, or moisture or potash deficiency. High nematode populations often...

  18. 10/11/2007 07:54 PMVirtual human has a roving eye -tech -10 October 2007 -New Scientist Tech Page 1 of 2http://technology.newscientist.com/article/dn12767-virtual-human-has-a-roving-eye.html

    E-Print Network [OSTI]

    Itti, Laurent

    > Search Tips HOME NEWS 'Transparent' gadget could trump iPhone interface Pentagon backs plan to beam solar power from space Virtual human has a roving eye Internet gets first full census for 25 years Are mirrors

  19. At What Distance Can the Human Eye Detect a Candle Flame?

    E-Print Network [OSTI]

    Krisciunas, Kevin

    2015-01-01

    Using CCD observations of a candle flame situated at a distance of 338 m and calibrated with observations of Vega, we show that a candle flame situated at ~2.6 km (1.6 miles) is comparable in brightness to a 6th magnitude star with the spectral energy distribution of Vega. The human eye cannot detect a candle flame at 10 miles or further, as some statements on the web suggest.

  20. Uranium associations and migration behaviour at the Needle’s Eye natural analogue site in SW Scotland 

    E-Print Network [OSTI]

    Xu, Xiaolu

    2015-06-30

    This thesis investigated uranium (U) migration behaviour at the Needle?s Eye natural analogue site, located close to Southwick Water, South West Scotland. The results of this study are important for the prediction of U ...

  1. Curvature-driven, One-step Assembly of Reconfigurable Smectic Liquid Crystal "Compound Eye" Lenses

    E-Print Network [OSTI]

    Francesca Serra; Mohamed A. Gharbi; Yimin Luo; Iris B. Liu; Nathan D. Bade; Randall D. Kamien; Shu Yang; Kathleen J. Stebe

    2015-05-06

    Confined smectic A liquid crystals (SmA LCs) form topological defects called focal conic domains (FCDs) that focus light as gradient-index lenses. Here, we exploit surface curvature to self-assemble FCDs in a single step into a hierarchical structure (coined "flower pattern") molded by the fluid interface that is pinned at the top of a micropillar. The structure resembles the compound eyes of some invertebrates, which consist of hundreds of microlenses on a curved interface, able to focus and construct images in three dimensions. Here we demonstrate that these flowers are indeed "compound eyes" with important features which have not been demonstrated previously in the literature. The eccentric FCDs gradually change in size with radial distance from the edge of the micropillar, resulting in a variable microlens focal length that ranges from a few microns to a few tens of microns within a single "flower". We show that the microlenses can construct a composite 3D image from different depth of field. Moreover, the smectic "compound eye" can be reconfigured by heating and cooling at the LC phase transition temperature; its field of view can be manipulated by tuning the curvature of the LC interface, and the lenses are sensitive to light polarization.

  2. A review of "The Eye of the Eagle: John Donne and the Legacy of Ignatius Loyola" by Francesca Bugliani Knox 

    E-Print Network [OSTI]

    Harris, Mitchell M.

    2012-01-01

    -century news Francesca Bugliani Knox. ?e Eye of the Eagle: John Donne and the Legacy of Ignatius Loyola. Bern: Peter Lang, 2011. Religions and Discourse Series. 342 pp. $75.95. Review by ?????? ?. ??????, ????????? ?? ??? (????? ?? ?). When I spotted... the provocative title of Francesca Bugliani Knox?s ?e Eye of the Eagle: John Donne and the Legacy of Ignatius Loyola for the ?rst time, my curiosity was piqued. Here was an academic monograph that could seemingly go in many directions. For example, it could...

  3. Development of Biomarkers for Chronic Beryllium Disease in Mice

    SciTech Connect (OSTI)

    Gordon, Terry

    2013-01-25

    Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an animal model which can be used for dissecting dose-response relationships and pathogenic mechanisms and for testing new diagnostic and treatment paradigms. We have created 3 strains of transgenic mice in which the human antigen-presenting moiety, HLA-DP, was inserted into the mouse genome. Each mouse strain contains HLA-DPB1 alleles that confer different magnitude of risk for chronic beryllium disease (CBD): HLA-DPB1*0401 (odds ratio = 0.2), HLA-DPB1*0201 (odds ratio = 15), HLA-DPB1*1701 (odds ratio = 240). Our preliminary work has demonstrated that the *1701 allele, as predicted by human studies, results in the greatest degree of sensitization in a mouse ear swelling test. We have also completed dose-response experiments examining beryllium-induced lung granulomas and identified susceptible and resistant inbred strains of mice (without the human transgenes) as well as quantitative trait loci that may contain gene(s) that modify the immune response to beryllium. In this grant application, we propose to use the transgenic and Â?normal inbred strains of mice to identify biomarkers for the progression of beryllium sensitization and CBD. To achieve this goal, we propose to compare the sensitivity and accuracy of the lymphocyte proliferation test (blood and bronchoalveolar lavage fluid) with the ELISPOT test in the three HLA-DP transgenic mice strains throughout a 6 month treatment with beryllium particles. Because of the availability of high-throughput proteomics, we will also identify changes in potential protein biomarkers in beryllium-treated mice. We will correlate these findings with the ability of the transgenic mice to develop a beryllium-specific adaptive immune response in blood and bronchoalveolar lavage (BAL) fluid. We will also determine whether beryllium-responsive CD4+ T cells in blood and BAL correlate with the onset of granuloma formation. Thus, we will provide the scientific community with biomarkers of sensitization and disease progression for CBD. These biomarkers will serve as critical tools for development of improved industrial hygiene and therapeutic interventions.

  4. Origin of the bright prompt optical emission in the naked eye burst

    SciTech Connect (OSTI)

    Hascoeet, R.; Daigne, F.; Mochkovitch, R.

    2010-10-15

    The huge optical brightness of GRB 080319B (the 'Naked Eye Burst') makes this event really challenging for models of the prompt GRB emission. In the framework of the internal shock model, we investigate a scenario where the dominant radiative process is synchrotron emission and the high optical flux is due to the dynamical properties of the relativistic outflow : if the initial Lorentz factor distribution in the jet is highly variable, many internal shocks will form within the outflow at various radii. The most violent shocks will produce the main gamma-ray component while the less violent ones will contribute at lower energy, including the optical range.

  5. Observation of magnetic field lines in the vicinity of a superconductor with the naked eye

    E-Print Network [OSTI]

    Yoshihiko Saito

    2008-11-04

    Meissner effect and pinning effect are clearly observed with the naked eye. A GdBaCuO high-temperature superconductor (HTS) disk fabricated by Nippon Steel Corporation, a 100mm cubic NdFeB sintered magnet, and iron wires coated by colored are used. When the HTS is put in the magnetic field of the magnet, it can be observed by the wires that the magnetic field lines are excluded from the superconductor (Meissner effect) as well as are pinned in the superconductor (pinning effect).

  6. Bio-inspired Electronics for Interfacing Artificial Implants to Living Systems Imagine a world in which damaged parts of the body -an arm, or an eye, or even

    E-Print Network [OSTI]

    Taylor, Richard

    in which damaged parts of the body - an arm, or an eye, or even a region of the brain ­ can be replaced

  7. Common Rose Diseases 

    E-Print Network [OSTI]

    Johnk, Janell

    2000-01-11

    is implied. 1. Plant roses in full sun.2. Use drip irrigation or soaker hoses. 3. Water in early morning.4. Selectively prune to open canopy and increase aircirculation. 5. Manage weeds and insects to prevent the spread of viruses. F i ve S te p..., making it moresusceptible to insect problems andother diseases.Management?Prune damaged orinfected canes . The black spot fungusover winters oncanes. Carefulpruning removesdamaged or infectedcanes and slowsdisease development. B lack Spot Rose varieties...

  8. Peanut Diseases Atlas. 

    E-Print Network [OSTI]

    Horne, Wendell C.

    1974-01-01

    Acknowledgments This publication was made possible by a grant from the Texas Peanut Producers Board to the Texas Agricultural Extension Service. This educational support in the area of peanut disease control is appreciated. The author also expresses... appreciation to producers who contributed through the voluntary check-off program and to those Extension staff members and research plant pathologists and nematologists who gave assistance and counsel during the prepara tion of this publication . Peanut...

  9. Bovine Respiratory Disease Max Irsik DVM, MAB

    E-Print Network [OSTI]

    Watson, Craig A.

    . The clinical signs are usually mild and involve coughing, nasal discharge, fever and a decreased appetite signs of BRD are nasal and eye discharges, coughing, fever, depressed appetite, varying degrees

  10. Inherited risk for common disease

    E-Print Network [OSTI]

    Banava, Helen

    2007-01-01

    Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

  11. PLANT DISEASES IN SOUTH CAROLINA

    E-Print Network [OSTI]

    Stuart, Steven J.

    INDEX OF PLANT DISEASES IN SOUTH CAROLINA James H. Blake, Ed.D. Director, Home & Garden Information to compile a list of plant diseases occurring on cultivated and native plants in South Carolina. The data or conclusive list of the diseases of plants in South Carolina. New plants as well as new plant pathogens

  12. A Manual of Poultry Diseases

    E-Print Network [OSTI]

    Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

    1965-01-01

    ............................................ Botlv Defense Against Disease 6 Manifestations of Disease ...................................................... 7 ........ Hatcherv and Breeder Flock Health Management 7 Hatchcrv Management and Sanitation ......... .... ........... 8 Principles... ......................................................... 10 Vaccination No Substitute for Sanitation .................... .. 11 Diseases for 'lIrhich Vaccines Are Available .................... 11 ....................... .................. Acl~ninistration of Vaccines ......... 11 -4 Suggested...

  13. A fully implantable intracochlear drug delivery device : development and characterization

    E-Print Network [OSTI]

    Swan, Erin Eileen Leary, 1976-

    2009-01-01

    In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

  14. Method and system for the diagnosis of disease using retinal image content and an archive of diagnosed human patient data

    DOE Patents [OSTI]

    Tobin, Kenneth W; Karnowski, Thomas P; Chaum, Edward

    2013-08-06

    A method for diagnosing diseases having retinal manifestations including retinal pathologies includes the steps of providing a CBIR system including an archive of stored digital retinal photography images and diagnosed patient data corresponding to the retinal photography images, the stored images each indexed in a CBIR database using a plurality of feature vectors, the feature vectors corresponding to distinct descriptive characteristics of the stored images. A query image of the retina of a patient is obtained. Using image processing, regions or structures in the query image are identified. The regions or structures are then described using the plurality of feature vectors. At least one relevant stored image from the archive based on similarity to the regions or structures is retrieved, and an eye disease or a disease having retinal manifestations in the patient is diagnosed based on the diagnosed patient data associated with the relevant stored image(s).

  15. Development of Graves' disease following radiation therapy in Hodgkin's disease

    SciTech Connect (OSTI)

    Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

    1988-01-01

    Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

  16. Typhoon eye trajectory based on a mathematical model: comparing with observational data

    E-Print Network [OSTI]

    Olga S. Rozanova; Jui-Ling Yu; Chin-Kun Hu

    2010-02-23

    We propose a model based on the primitive system of the Navier-Stokes equations in a bidimensional framework as the $l$ - plane approximation, which allows us to explain the variety of tracks of tropical cyclones (typhoons). Our idea is to construct special analytical solutions with a linear velocity profile for the Navier-Stokes systems. The evidence of the structure of linear velocity near the center of vortex can be proven by the observational data. We study solutions with the linear-velocity property for both barotropic and baroclinic cases and show that they follow the same equations in describing the trajectories of the typhoon eye at the equilibrium state (that relates to the conservative phase of the typhoon dynamics). Moreover, at the equilibrium state, the trajectories can be viewed as a superposition of two circular motions: one has period $2\\pi/l,$ the other one has period $2\\pi/b_0,$ where $l$ is the Coriolis parameter and $b_0$ is the height-averaged vorticity at the center of cyclone. Also, we compare our theoretical trajectories based on initial conditions from the flow with tracks obtained from the observational database. It is worth to mention that under certain conditions our results are still compatible with observational data although we did not truly consider the influence of steering effect. %Note that the %motion of the typhoon eye can not be totally determinated by initial %conditions due to the effect of ambient pressure field ("steering" %effect). Finally, we propose the parameter-adopting method so that one could correct the weather prediction in real time. Examples of our analysis and the use of parameter-adopting method for the historic trajectories are provided.

  17. Performance of "Moth Eye" Anti-Reflective Coatings for Solar Cell Applications

    SciTech Connect (OSTI)

    Clark, E.; Kane, M.; Jiang, P.

    2011-03-14

    An inexpensive, effective anti-reflective coating (ARC) has been developed at the University of Florida to significantly enhance the absorption of light by silicon in solar cells. This coating has nano-scale features, and its microstructure mimics that of various night active insects (e.g. a moth's eye). It is a square array of pillars, each about 700 nm high and having a diameter of about 300 nm. Samples of silicon having this coating were exposed either to various combinations of either elevated temperature and humidity or to gamma irradiation ({sup 60}Co) at the Savannah River National Laboratory, or to a broad spectrum ultraviolet light and to a 532 nm laser light at the University of Florida. The anti-reflective properties of the coatings were unaffected by any of these environmental stresses, and the microstructure of the coating was also unaffected. In fact, the reflectivity of the gamma irradiated ARC became lower (advantageous for solar cell applications) at wavelengths between 400 and 1000 nm. These results show that this coating is robust and should be tested in actual systems exposed to either weather or a space environment. Structural details of the ARCs were studied to optimize their performance. Square arrays performed better than hexagonal arrays - the natural moth-eye coating is indeed a square array. The optimal depth of the templated nanopillars in the ARC was investigated. A wet etching technology for ARC formation was developed that would be less expensive and much faster than dry etching. Theoretical modeling revealed that dimple arrays should perform better than nipple arrays. A method of fabricating both dimple and nipple arrays having the same length was developed, and the dimple arrays performed better than the nipple arrays, in agreement with the modeling. The commercial viability of the technology is quite feasible, since the technology is scalable and inexpensive. This technology is also compatible with current industrial fabrication of solar cells.

  18. Proceedings of the First Workshop on Eye-tracking and Natural Language Processing, pages 520, COLING 2012, Mumbai, December 2012.

    E-Print Network [OSTI]

    ­20, COLING 2012, Mumbai, December 2012. IDENTIFYING INSTANCES OF PROCESSING EFFORT IN TRANSLATION THROUGH HEAT MAPS: an eye-tracking study using multiple input sources Fabio ALVES1, José Luiz GONÇALVES2 maps of different subjects to select and analyse translation problems. The results yield relevant

  19. Abstract: In this paper, we propose a fast and practical head pose estimation scheme for eye-head controlled

    E-Print Network [OSTI]

    Daume III, Hal

    -head controlled human computer interface with non-constrained background. The method we propose uses complete a novel image-based human computer interface controlled by eye and head, which is a subtask]. Conventional human computer interaction techniques such as keyboard and mouse are considered as bottlenecks

  20. STRUCTURAL AND IMMUNOCYTOCHEMICAL ALTERATIONS IN EYE LENS FIBER CELLS FROM Cx46 AND Cx50 KNOCKOUT MICE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 STRUCTURAL AND IMMUNOCYTOCHEMICAL ALTERATIONS IN EYE LENS FIBER CELLS FROM Cx46 AND Cx50 KNOCKOUT organization of lens fiber cells in connexin 46 (Cx46) and connexin 50 (Cx50) knockout mice. Morphometric analyses and the application of immunocytochemical techniques revealed that in Cx46 knockout lens (Cx46

  1. Cayman Turtles in the Eye of the Hurricane Two Cayman turtles survived Hurricane Wilma at sea, when

    E-Print Network [OSTI]

    Exeter, University of

    Cayman Turtles in the Eye of the Hurricane Two Cayman turtles survived Hurricane Wilma at sea, when rode out the hurricane at depths of several hundred feet below the surface, though they must have nesting, they migrate back to feeding grounds 2) "Lost years" in the open ocean Turtle hatching drifting

  2. Media Summary 6 12 Dec 2014 Eye Witness News 3D printing technology creates robotic hands for kids

    E-Print Network [OSTI]

    Aickelin, Uwe

    Media Summary 6 ­ 12 Dec 2014 Coverage Eye Witness News ­ 3D printing technology creates robotic Magazine) - The rise of the (more ethical) machines Mail Online - How to prevent robot world domination - UK researchers join hands to make safer, more ethical, autonomous robots Business Week - New research

  3. 1858 IEEE TRANSACTIONS ON SIGNAL PROCESSING, VOL. 57, NO. 5, MAY 2009 A Biologically Inspired Compound-Eye Detector

    E-Print Network [OSTI]

    Nehorai, Arye

    artificial vision in medicine or robotics, astronomy assisted, security, and particle communications. Index- sors in applications such as artificial vision, which can be impor- tant in robotics (see, e.g., [1 Terms--Artificial compound eye, biologically inspired, biomimetics, dilogarithm function, fundamental

  4. Anglers who have been offshore fishing have most likely seen the bulging eyes, protruding stomach and distended

    E-Print Network [OSTI]

    Watson, Craig A.

    Anglers who have been offshore fishing have most likely seen the bulging eyes, protruding stomach and distended intestines of a fish brought up from deep water on hook and line. You might wonder if there is hope for such fish. As with human divers, fish that experience rapid pressure change can suffer a host

  5. Neuron, Vol. 35, 961974, August 29, 2002, Copyright 2002 by Cell Press Saccadic Eye Movements Modulate Visual

    E-Print Network [OSTI]

    Reid, R. Clay

    Neuron, Vol. 35, 961­974, August 29, 2002, Copyright 2002 by Cell Press Saccadic Eye Movements generally John B. Reppas,1 W. Martin Usrey,1,3 and R. Clay Reid1,2 1 Department of Neurobiology Harvard regions of the visual scene and allow examina- tivity of magnocellular neurons. However, previous stud

  6. The etiology of loin disease 

    E-Print Network [OSTI]

    Greeley, Ralph Gordon

    1966-01-01

    treatment has been discovered and the etiology of the disease has never been proven. In South Africa a similar disease, larnsiekte, has been recorded for centuries. In the 1920's intensive research in that country un- covered a chain of conditions... the similarity of lamsiekte and loin disease, and of the phosphorus deficiency that soils of South Africa and the Texas coastal plains have in common. In 1924 he began recommending the routine supplemental feeding of phos- phorus to range cattle (8). Where...

  7. Using Wikipedia to forecast diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Molecular Biologist, of the Mathematical and Computational Epidemiology Team at Los Alamos National Laboratory Science Friday Interviews Mining Wikipedia Data to Track Disease...

  8. Dual Wavelength Polarimetry for Glucose Sensing in the Anterior Chamber of the Eye 

    E-Print Network [OSTI]

    Malik, Bilal Hameed

    2012-02-14

    Clinical guidelines dictate that frequent blood glucose monitoring in diabetic patients is critical towards proper management of the disease. Although, several different types of glucose monitors are now commercially ...

  9. Environmental Contributions to Allergic Disease

    E-Print Network [OSTI]

    Levetin, Estelle

    with increased exposure to air pollution and indoor contaminants such as house dust mites, cockroaches disease is more complex than increased exposure to pollution and allergens and that early childhood of outdoor factors to allergic disease. Influence of Exposure to Pollutants on the Manifestation of Allergic

  10. Publications Fish Disease Diagnosis and

    E-Print Network [OSTI]

    Publications Fish Disease Diagnosis and Basic Fishery Computer Programs The second edition of "Disease Diagnosis and Control in North American Marine Aquaculture," edited by Carl J. Sindermann edition should be a big help to aquaculturists and others involved in the detection, prevention

  11. Occupational Disease in Connecticut, 2014

    E-Print Network [OSTI]

    Oliver, Douglas L.

    Occupational Disease in Connecticut, 2014 This report covers data for 2012 and was prepared under contract for the State of Connecticut Workers' Compensation Commission, John A. Mastropietro, Chairman, as part of the Occupational Disease Surveillance Program, operated in cooperation with the Connecticut

  12. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  13. GRB 080319B: A Naked-Eye Stellar Blast from the Distant Universe

    SciTech Connect (OSTI)

    Racusin, J. L.; Burrows, D. N.

    2008-10-22

    On behalf of a large international collaboration [1], we present the unprecedented broadband observations of GRB 080319B, whose prompt optical emission peaked at a visual magnitude of 5.3, making it briefly visible with the naked eye. GRB 080319B was discovered by Swift and captured in exquisite detail by ground based wide-field telescopes, imaging the burst location from before the time of the explosion. The combination of these unique optical data with simultaneous {gamma}-ray observations provides powerful diagnostics of the detailed physics of this explosion within seconds of its formation. We show that the prompt optical and {gamma}-ray emissions from this event arise from different spectral components within the same physical region located at a large distance from the source, implying an extremely relativistic outflow. Our observations also provide good evidence for a bright reverse shock component. The chromatic behavior of the broadband afterglow is consistent with viewing the GRB down the very narrow inner core of a two-component jet that is expanding into a wind-like environment consistent with the massive star origin of long GRBs.

  14. FREQUENCY LIMITS ON NAKED-EYE OPTICAL TRANSIENTS LASTING FROM MINUTES TO YEARS

    SciTech Connect (OSTI)

    Shamir, Lior; Nemiroff, Robert J. E-mail: nemiroff@mtu.edu

    2009-09-15

    How often do bright optical transients occur on the sky but go unreported? To constrain the bright end of the astronomical transient function, a systematic search for transients that become bright enough to be noticed by the unaided eye was conducted using the all-sky monitors of the Night Sky Live network. Two fisheye CONtinuous CAMeras operating over three years created a database that was searched for transients that appeared in time-contiguous CCD frames. Although a single candidate transient was found, the lack of more transients is used here to deduce upper limits to the general frequency of bright transients. To be detected, a transient must have increased by over three visual magnitudes to become brighter than visual magnitude 5.5 on the timescale of minutes to years. It is concluded that, on the average, fewer than 0.0040 (t {sub dur}/60 s) transients with duration t {sub dur} between minutes and hours, occur anywhere on the sky at any one time. For transients on the order of months to years, fewer than 160 (t {sub dur}/1 year) occur, while for transients on the order of years to millennia, fewer than 50 (t {sub dur}/1 year){sup 2} occur.

  15. GRB 080319B: A Naked-Eye Stellar Blast from the Distant Universe

    E-Print Network [OSTI]

    J. L. Racusin; S. V. Karpov; M. Sokolowski; J. Granot; X. F. Wu; V. Pal'shin; S. Covino; A. J. van der Horst; S. R. Oates; P. Schady; R. J. Smith; J. Cummings; R. L. C. Starling; L. W. Piotrowski; B. Zhang; P. A. Evans; S. T. Holland; K. Malek; M. T. Page; L. Vetere; R. Margutti; C. Guidorzi; A. Kamble; P. A. Curran; A. Beardmore; C. Kouveliotou; L. Mankiewicz; A. Melandri; P. T. O'Brien; K. L. Page; T. Piran; N. R. Tanvir; G. Wrochna; R. L. Aptekar; C. Bartolini; S. Barthelmy; G. M. Beskin; S. Bondar; S. Campana; A. Cucchiara; M. Cwiok; P. D'Avanzo; V. D'Elia; M. Della Valle; W. Dominik; A. Falcone; F. Fiore; D. B. Fox; D. D. Frederiks; A. S. Fruchter; D. Fugazza; M. Garrett; N. Gehrels; S. Golenetskii; A. Gomboc; G. Greco; A. Guarnieri; S. Immler; G. Kasprowicz; A. J. Levan; E. P. Mazets; E. Molinari; A. Moretti; K. Nawrocki; P. P. Oleynik; J. P. Osborne; C. Pagani; Z. Paragi; M. Perri; A. Piccioni; E. Ramirez-Ruiz; P. W. A. Roming; I. A. Steele; R. G. Strom; V. Testa; G. Tosti; M. V. Ulanov; K. Wiersema; R. A. M. J. Wijers; A. F. Zarnecki; F. Zerbi; P. Meszaros; G. Chincarini; D. N. Burrows

    2008-05-11

    Long duration gamma-ray bursts (GRBs) release copious amounts of energy across the entire electromagnetic spectrum, and so provide a window into the process of black hole formation from the collapse of a massive star. Over the last forty years, our understanding of the GRB phenomenon has progressed dramatically; nevertheless, fortuitous circumstances occasionally arise that provide access to a regime not yet probed. GRB 080319B presented such an opportunity, with extraordinarily bright prompt optical emission that peaked at a visual magnitude of 5.3, making it briefly visible with the naked eye. It was captured in exquisite detail by wide-field telescopes, imaging the burst location from before the time of the explosion. The combination of these unique optical data with simultaneous gamma-ray observations provides powerful diagnostics of the detailed physics of this explosion within seconds of its formation. Here we show that the prompt optical and gamma-ray emissions from this event likely arise from different spectral components within the same physical region located at a large distance from the source, implying an extremely relativistic outflow. The chromatic behaviour of the broadband afterglow is consistent with viewing the GRB down the very narrow inner core of a two-component jet that is expanding into a wind-like environment consistent with the massive star origin of long GRBs. These circumstances can explain the extreme properties of this GRB.

  16. Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease

    E-Print Network [OSTI]

    Watts, Amber; Crimmins, Eileen M.; Gatz, Margaret

    2008-09-10

    Periodontal disease (PDD) is associated with increased risk of cardiovascular disease, cerebrovascular disease, and mortality in many studies, while other studies have begun to suggest an association of PDD with Alzheimer’s disease (AD). This paper...

  17. A comparative clinico-pathologic investigation of the effect of chloroquine phosphate on the eyes and brain of several animal species 

    E-Print Network [OSTI]

    Dukes, Thomas William

    1969-01-01

    Laboratories, Fort Worth, Texas. ++*Keeler Optical Products, Inc. , Philadelphia, Pennsylvania. 13 tempted because of the questionable value of the results and the 8, 20 difficulties encountered in obtaining them. At necropsy, the eyes were carefully...

  18. Alzheimer's Disease and Vitamin E

    E-Print Network [OSTI]

    Empey, Matthew

    1998-01-01

    Adelman A. Selegiline and vitamin E in Alzheimer's disease.bomb. Geriatrics Traber MG. Vitamin E in humans: Demand andJ, Cole GM, Schubert D. Vitamin E protects nerve cells from

  19. A Manual of Poultry Diseases

    E-Print Network [OSTI]

    Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

    1971-01-01

    ........................................................ 7 Flock Health Management 7 Hatchery Management and Sanitation ............................ 8 Principles of Reasonable Drug Administration ................. .... 9 Drug Administration... Vaccines Are ................................................................... 10 Dangers of Vaccination ........................................................... 10 Vaccination-No Substitute for Sanitation ..... .................... 11 Diseases...

  20. Prudent behaviour accelerates disease transmission

    E-Print Network [OSTI]

    Scarpino, Samuel V; Hebert-Dufresne, Laurent

    2015-01-01

    Infectious diseases often spread faster near their peak than would be predicted given early data on transmission. Despite the commonality of this phenomena, there are no known general mechanisms able to cause an exponentially spreading dis- ease to begin spreading faster. Indeed most features of real world social networks, e.g. clustering1,2 and community structure3, and of human behaviour, e.g. social distancing4 and increased hygiene5, will slow disease spread. Here, we consider a model where individuals with essential societal roles-e.g. teachers, first responders, health-care workers, etc.- who fall ill are replaced with healthy individuals. We refer to this process as relational exchange. Relational exchange is also a behavioural process, but one whose effect on disease transmission is less obvious. By incorporating this behaviour into a dynamic network model, we demonstrate that replacing individuals can accelerate disease transmission. Furthermore, we find that the effects of this process are trivial w...

  1. Diarrheal Disease in Show Swine 

    E-Print Network [OSTI]

    Lawhorn, D. Bruce

    2007-02-27

    from the feces of recovered car- rier pigs or from contaminated premises, trailers or scales. Pigs affected with this disease usually become very sick. This organism infects the cells lining the cecum and spiral colon (the same area as whipworms... disease in show pigs. Infection occurs after pigs ingest microscopic whipworm eggs while rooting or eating in a contaminat- ed environment. Whipworm eggs remain viable for as long as 6 years so contaminated premises are an impor- tant source of infection...

  2. Controlling Diseases on Ornamental Plants. 

    E-Print Network [OSTI]

    Horne, C. Wendell; Johnson, Jerral D.; Walla, Walter J.

    1979-01-01

    on elms and other shade trees. Mushroom-type fu ngal growths appear on trunk, limbs or roots near the soil surface. Rots may be present for several years before mushrooms ap pear. Tree becomes sus ceptible to wi nd damage. Plants may die back..., irises, lilies, narcissus and tulips. ROOT DISEASES Disease Cotton root rot (fungi) Crown gall Mushroom root rot Symptoms Small flowering plants die within a few days. Shrubs and trees die more slowly. Large trees may die within several...

  3. CONSTRAINTS ON THE EMISSION MODEL OF THE 'NAKED-EYE BURST' GRB 080319B

    SciTech Connect (OSTI)

    Abdo, A. A.; Abeysekara, A. U.; Linnemann, J. T.; Allen, B. T.; Chen, C.; Aune, T.; Berley, D.; Goodman, J. A.; Christopher, G. E.; Kolterman, B. E.; Mincer, A. I.; DeYoung, T.; Dingus, B. L.; Hoffman, C. M.; Ellsworth, R. W.; Gonzalez, M. M.; Granot, J.; Hays, E.; McEnery, J. E.; Huentemeyer, P. H.; and others

    2012-07-10

    On 2008 March 19, one of the brightest gamma-ray bursts (GRBs) ever recorded was detected by several ground- and space-based instruments spanning the electromagnetic spectrum from radio to gamma rays. With a peak visual magnitude of 5.3, GRB 080319B was dubbed the 'naked-eye' GRB, as an observer under dark skies could have seen the burst without the aid of an instrument. Presented here are results from observations of the prompt phase of GRB 080319B taken with the Milagro TeV observatory. The burst was observed at an elevation angle of 47 Degree-Sign . Analysis of the data is performed using both the standard air shower method and the scaler or single-particle technique, which results in a sensitive energy range that extends from {approx}5 GeV to >20 TeV. These observations provide the only direct constraints on the properties of the high-energy gamma-ray emission from GRB 080319B at these energies. No evidence for emission is found in the Milagro data, and upper limits on the gamma-ray flux above 10 GeV are derived. The limits on emission between {approx}25 and 200 GeV are incompatible with the synchrotron self-Compton model of gamma-ray production and disfavor a corresponding range (2 eV-16 eV) of assumed synchrotron peak energies. This indicates that the optical photons and soft ({approx}650 keV) gamma rays may not be produced by the same electron population.

  4. Gamma-Ray Burst at the extreme: "the naked-eye burst" GRB 080319B

    E-Print Network [OSTI]

    P. R. Wozniak; W. T. Vestrand; A. D. Panaitescu; J. A. Wren; H. R. Davis; R. R. White

    2008-10-14

    On 19 March 2008, the northern sky was the stage of a spectacular optical transient that for a few seconds remained visible to the naked eye. The transient was associated with GRB 080319B, a gamma-ray burst at a luminosity distance of about 6 Gpc (standard cosmology), making it the most luminous optical object ever recorded by human kind. We present comprehensive sky monitoring and multi-color optical follow-up observations of GRB 080319B collected by the RAPTOR telescope network covering the development of the explosion and the afterglow before, during, and after the burst. The extremely bright prompt optical emission revealed features that are normally not detectable. The optical and gamma-ray variability during the explosion are correlated, but the optical flux is much greater than can be reconciled with single emission mechanism and a flat gamma-ray spectrum. This extreme optical behavior is best understood as synchrotron self-Compton model (SSC). After a gradual onset of the gamma-ray emission, there is an abrupt rise of the prompt optical flux suggesting that variable self-absorption dominates the early optical light curve. Our simultaneous multi-color optical light curves following the flash show spectral evolution consistent with a rapidly decaying red component due to large angle emission and the emergence of a blue forward shock component from interaction with the surrounding environment. While providing little support for the reverse shock that dominates the early afterglow, these observations strengthen the case for the universal role of the SSC mechanism in generating gamma-ray bursts.

  5. Observations of the Naked-Eye GRB 080319B: Implications of Nature's Brightest Explosion

    E-Print Network [OSTI]

    J. S. Bloom; D. A. Perley; W. Li; N. R. Butler; A. A. Miller; D. Kocevski; D. A. Kann; R. J. Foley; H. -W. Chen; A. V. Filippenko; D. L. Starr; B. Macomber; J. X. Prochaska; R. Chornock; D. Poznanski; S. Klose; M. F. Skrutskie; S. Lopez; P. Hall; K. Glazebrook; C. H. Blake

    2008-12-15

    The first gamma-ray burst (GRB) confirmed to be bright enough to be seen with the naked eye, GRB 080319B at redshift z = 0.937, allowed for exquisite follow-up observations across the electromagnetic spectrum. We present our detailed optical and infrared observations of the afterglow, consisting of over 5000 images starting 51 s after the GRB trigger, in concert with our own analysis of the Swift data. The event is extreme not only in observed properties but intrinsically: it was the most luminous event ever recorded at optical and infrared wavelengths and had an exceedingly high isotropic-equivalent energy release in gamma-rays. At early times, the afterglow evolution is broadly consistent with being reverse-shock dominated, but then is subsumed by a forward shock at around 1000 s. The overall spectral energy distribution, spanning from ultraviolet through near-infrared wavelengths, shows no evidence for a significant amount of dust extinction in the host frame. The afterglow evolution, however, is highly chromatic: starting at about 1000 s the index shifts blueward before shifting back to the red at late times. In our deepest late-time observations, we find tentative evidence for an optical jet break and a luminous supernova. Finally, we examine the detectability of such events with current and future facilities and find that such an event could be detected in gamma-rays by BAT out to z = 10.7 (8 sigma), while the nominal EXIST sensitivity would allow detection to z ~ 32. At K band, this source would have been easily detected with meter-class telescopes to z ~ 17.

  6. Registration of clinical volumes to beams-eye-view images for real-time tracking

    SciTech Connect (OSTI)

    Bryant, Jonathan H.; Rottmann, Joerg; Lewis, John H.; Mishra, Pankaj; Berbeco, Ross I.; Keall, Paul J.

    2014-12-15

    Purpose: The authors combine the registration of 2D beam’s eye view (BEV) images and 3D planning computed tomography (CT) images, with relative, markerless tumor tracking to provide automatic absolute tracking of physician defined volumes such as the gross tumor volume (GTV). Methods: During treatment of lung SBRT cases, BEV images were continuously acquired with an electronic portal imaging device (EPID) operating in cine mode. For absolute registration of physician-defined volumes, an intensity based 2D/3D registration to the planning CT was performed using the end-of-exhale (EoE) phase of the four dimensional computed tomography (4DCT). The volume was converted from Hounsfield units into electron density by a calibration curve and digitally reconstructed radiographs (DRRs) were generated for each beam geometry. Using normalized cross correlation between the DRR and an EoE BEV image, the best in-plane rigid transformation was found. The transformation was applied to physician-defined contours in the planning CT, mapping them into the EPID image domain. A robust multiregion method of relative markerless lung tumor tracking quantified deviations from the EoE position. Results: The success of 2D/3D registration was demonstrated at the EoE breathing phase. By registering at this phase and then employing a separate technique for relative tracking, the authors are able to successfully track target volumes in the BEV images throughout the entire treatment delivery. Conclusions: Through the combination of EPID/4DCT registration and relative tracking, a necessary step toward the clinical implementation of BEV tracking has been completed. The knowledge of tumor volumes relative to the treatment field is important for future applications like real-time motion management, adaptive radiotherapy, and delivered dose calculations.

  7. the heart truth What is heart Disease?

    E-Print Network [OSTI]

    Shen, Jun

    the heart truth® for Women What is heart Disease? Coronary heart disease (CHD) is the most common form of heart disease. Usually referred to simply as "heart disease," it is a disorder of the blood vessels of the heart in which a waxy substance called plaque builds up in the coronary (heart) arteries

  8. 200 Plant Disease / Vol. 87 No. 2200 Disease Notes

    E-Print Network [OSTI]

    Pappu, Hanu R.

    Leaf Curl Begomoviruses from Pakistan. S. L. Shih, W. S. Tsai, and S. K. Green, The Asian Vegetable Disease Research Institute, National Agricultural Research Centre, Islamabad, Pakistan; M. A. Rezaian in Pakistan. One chili sample with leaf curl symptoms was collected in 1998 in Multan (Punjab Province

  9. Naked-eye optical flash from gamma-ray burst 080319B: Tracing the decaying neutrons in the outflow

    SciTech Connect (OSTI)

    Fan Yizhong; Zhang Bing; Wei Daming

    2009-01-15

    For an unsteady baryonic gamma-ray burst (GRB) outflow, the fast and slow proton shells collide with each other and produce energetic soft gamma-ray emission. If the outflow has a significant neutron component, the ultrarelativistic neutrons initially expand freely until decaying at a larger radius. The late-time proton shells ejected from the GRB central engine, after powering the regular internal shocks, will sweep these {beta}-decay products and give rise to very bright UV/optical emission. The naked-eye optical flash from GRB 080319B, an energetic explosion in the distant Universe, can be well explained in this way.

  10. A Fast Algorithm for Eye Detection Using Two-Dimensional CSP Akiko SUZUKI Tetsuya TAKIGUCHI Yasuo ARIKI

    E-Print Network [OSTI]

    Takiguchi, Tetsuya

    CSP A Fast Algorithm for Eye Detection Using Two-Dimensional CSP Akiko SUZUKI Tetsuya TAKIGUCHI Yasuo ARIKI 1. , CSP Crosspower-Spectrum Phase 2 [1] [2][3] CSP 2. W × H I(x, y) w × h T(i, j) R(x, y) R(x, y) (4) 3. CSP 1 CSP I(x, y) T(i, j) I(1, 2) = x,y I(x, y)e-j1x e-j2y (5) T(1, 2) = i,j T(i, j)e-j1

  11. MAR 384 -DISEASES OF AQUATIC ORGANISMS (3 credits)

    E-Print Network [OSTI]

    Allam, Bassem

    . Disease management 26. Advances in aquatic animal disease Part I (vaccination, probiotics) 27. Advances

  12. Patching genes to fight disease

    SciTech Connect (OSTI)

    Holzman, D.

    1990-09-03

    The National Institutes of Health has approved the first gene therapy experiments, one of which will try to cure cancer by bolstering the immune system. The applications of such therapy are limited, but the potential aid to people with genetic diseases is great.

  13. Disease Management in Organic Plantings

    E-Print Network [OSTI]

    Isaacs, Rufus

    cooling or proper drying · Clean harvesting and processing equipment · Control insects that may createGard (Gliocladium virens) Blight Ban (Pseudomonas fluorescens) PlantShield (Trichoderma harzianum) Agri Antibiotics for control of bacterial diseases #12;Effect of Trichoderma hamatum (T382) in potting mix

  14. Easy Gardening.....Disease Control 

    E-Print Network [OSTI]

    Johnson, Jerral; Johnson, Jerral

    2009-05-29

    on plant roots and cause stunted plants. The most damaging nematode in the home garden is root knot. It causes galls or knots on susceptible plants such as toma- A good home gardener recognizes the symptoms of plant diseases quickly and takes steps...

  15. Social Cognition in Frontotemporal Dementia, Motor Neurone Disease, and Alzheimer's Disease 

    E-Print Network [OSTI]

    Oliver, Lindsay

    2011-11-23

    cognition across a number of neurodegenerative diseases, a test battery and two questionnaires were administered to frontal variant frontotemporal dementia (fvFTD), motor neurone disease (MND), Alzheimer`s disease, and healthy control participant groups...

  16. Why Do We Get Alzheimer's Disease?

    SciTech Connect (OSTI)

    Wyss-Coray, Tony (Stanford University) [Stanford University

    2006-01-02

    Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

  17. Best Management Practices for Equine Disease Prevention 

    E-Print Network [OSTI]

    Scott, Brett D.

    2008-10-06

    AnimalDiseases,Revised1998] SchoolofVeterinaryMedicine,UniversityofWisconsin- Madison. Zoonotic Diseases Tutorial. www.vetmed.wisc.edu/pbs/zoonoses Hammer,Carolyn,2005, Equine Biological Risk Management.IowaStateUniversity. www.cfsph.iastate.edu Griffin...

  18. Karnal Bunt: A Disease of Wheat 

    E-Print Network [OSTI]

    Schuster, Greta; Krausz, Joseph P.; Rush, Charlie

    2002-11-20

    Karnal bunt is a fungal disease that affects wheat, durum wheat and triticale. This publication explains the life cycle of the disease, how it spreads, and methods of control....

  19. Does Drinking Tea Protect Against Cardiovascular Disease?

    E-Print Network [OSTI]

    Thompson, Natasha

    2003-01-01

    Maclure M, Muller JE et al. Tea consumption and mortalityU, Poole C, Arab L. Does Tea Affect Cardiovascular Disease?al. Regular Ingestion of black tea improves brachial artery

  20. New Clues in Predicting Alzheimer's Disease

    ScienceCinema (OSTI)

    Jagust, William

    2013-05-29

    Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

  1. MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW

    E-Print Network [OSTI]

    Missouri-Rolla, University of

    , coughing and having close social contact (living in the same household) are examples of how this disease

  2. Biomarker for Lung and Inflammatory Diseases

    E-Print Network [OSTI]

    Heydari, Payam

    Biomarker for Lung and Inflammatory Diseases Tech ID: 23381 / UC Case 2012-660-0 BACKGROUND and clinical research. We describe herein a novel biomarker and method of detecting interstitial lung disease have discovered that patients with interstitial lung and intestinal inflammatory diseases, for example

  3. Linkage Disequilibrium Mapping and Parkinson's Disease

    E-Print Network [OSTI]

    Parkinson's Disease Genetics Study Group, Science 279, 1116 (1998); T. Lynch et al., ibid., 278, 1212 (1997Linkage Disequilibrium Mapping and Parkinson's Disease Several investigators (1) have questioned with Parkinson's disease (PD) in four appar- ently unrelated Italian and Greek families, may be a cause

  4. A morphological comparison of the eyes of some falconiform and passeriform birds with special reference to: Passer domesticus, Mimus polyglottos, Sturnella magna, Falco sparverius, Cathartes aura, and Buteo jamaicensis 

    E-Print Network [OSTI]

    Lord, Rexford D

    1953-01-01

    ae to vivant ea attsatiaa, The eye Xsogth ie the% dietae? Rom the eyes af eureature of the cornea, te the eyyaeite ?pea of egmtgye of the eels' ia the oeatee o? th? fedora The men tavern'el disesteem is the distance fne the earn% ?ide of the ego...

  5. Akt Isoforms in Vascular Disease

    E-Print Network [OSTI]

    Yu, Haixiang; Littlewood, Trevor; Bennett, Martin

    2015-04-28

    aneurysm; eNOS, endothelial nitric oxide synthase;mTOR,mammalian target of rapamycin. 44 1223 331505. . This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). orms in vascular disease, Vascul. Pharmacol. (2015... p85 subunit and a catalytic p110 subunit that directly phosphorylates the ribosomal protein kinase p70s6k [29], the rho family polypeptide Rac [30], the serum and glucocorticoid-induced kinases SGK [31–33], and the serine/threonine kinase Akt [34...

  6. Diseases of Peaches and Plums. 

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01

    the possibility of root injury during cultivation as much as possible. Mushroom Root Rot Mushroom root rot is a fungal disease commonly known as "post oak root rot," "shoestring root rot" or "mushroom root rot." It attacks peach, pear, plum, apple and many... trees. Do not replant trees in old orchard sites infested with mushroom root rot. Cotton Root Rot Peach and plum trees die suddenly after show ing first symptoms of wilting. When roots are pulled from the soil, the bark is decayed, and covered...

  7. Gold nanoparticles-based brachytherapy enhancement in choroidal melanoma using a full Monte Carlo modelling of human eye

    E-Print Network [OSTI]

    Asadi, Somayeh; Masoudi, S Farhad; Rahmani, Faezeh

    2014-01-01

    Materials of high atomic number such as gold, can provide a high probability for photon interaction by photoelectric effects during radiation therapy. In cancer therapy, the object of brachytherapy as a kind of radiotherapy is to deliver adequate radiation dose to tumor while sparing surrounding healthy tissue. Several studies demonstrated that the preferential accumulation of gold nanoparticles within the tumor can enhance the absorbed dose by the tumor without increasing the radiation dose delivered externally. Accordingly, the required time for tumor irradiation decreases as the estimated adequate radiation dose for tumor is provided following this method. The dose delivered to healthy tissue is reduced when the time of irradiation is decreased. Hear, GNPs effects on choroidal Melanoma dosimetry is discussed by Monte Carlo study. Monte Carlo Ophthalmic brachytherapy dosimetry usually, is studied by simulation of water phantom. Considering the composition and density of eye material instead of water in thes...

  8. p-air cross-section measurement at 1018.5 for the High Resolution Fly's Eye (HiRes) Collaboration.

    E-Print Network [OSTI]

    p-air cross-section measurement at 1018.5 eV. K. Belova for the High Resolution Fly's Eye (Hi, USA We present the first measurement of p-air inelastic cross-section at 1018.5 eV using the Hi distribution is proposed. Monte Carlo simulations with the CORSIKA air shower generator and QGSJet and SIBYLL2

  9. Testosterone and prolactin in two songbirds that differ in paternal care: the blue-headed vireo and the red-eyed vireo

    E-Print Network [OSTI]

    Ketterson, Ellen D.

    ) and prolactin (PRL). Concentrations of plasma T and PRL were compared in breeding Blue-headed Vireos (Vireo incubation, respectively. In male Blue-headed Vireos, plasma T remained low from prenesting to fledgling stages; whereas in male Red-eyed Vireos, plasma T was highest during prenesting and progressively

  10. In this paper, we propose a robust, fast and cheap scheme for locating the eyes, lip-corners, and nostrils for

    E-Print Network [OSTI]

    Daume III, Hal

    -corners, and nostrils for Eye-Head Controlled Human Computer Interface on a facial image with non-constrained background gaze. Conventional human computer interaction techniques such as keyboard and mouse are being seen: Computer Interface, Virtual Reality and Games, Robot Control, Disabled Aid, Behavioral Psychology, Teaching

  11. The Flying Pi Eye is an autonomous, flying drone with four rotors that lift a Raspberry Pi, GPS, and camera. The drone is

    E-Print Network [OSTI]

    Gray, Jeffrey G.

    The Flying Pi Eye is an autonomous, flying drone with four rotors that lift a Raspberry Pi, GPS a user connects the on board Raspberry Pi through ethernet to a network, sets the search area and color to battery limitations. · The Raspberry Pi is small, inexpensive, and doesn't use much power, but it also

  12. COMPUTED TEAR FILM AND OSMOLARITY DYNAMICS ON AN EYE-SHAPED Longfei Li, Richard J. Braun, Tobin A. Driscoll, William D. Henshaw,

    E-Print Network [OSTI]

    COMPUTED TEAR FILM AND OSMOLARITY DYNAMICS ON AN EYE-SHAPED DOMAIN By Longfei Li, Richard J. Braun://www.ima.umn.edu #12;Mathematical Medicine and Biology Page 1 of 37 doi:10.1093/imammb/dqnxxx Computed Tear Film [Last modified: July 29, 2014] The concentration of ions, or osmolarity, in the tear film is a key

  13. Yarbus lives: a foveated exploration of how task influences saccadic eye movements Jonathan D. Nelson*, Garrison W. Cottrell^, Javier R. Movellan^^ and Martin I. Sereno*

    E-Print Network [OSTI]

    Nelson, Jonathan D.

    Yarbus lives: a foveated exploration of how task influences saccadic eye movements Jonathan D different tasks, with the same stimulus images. Tasks varied from ascertaining the weather, to free viewing imaging. Science 268:889-893. Images, left to right, from: home.fujifilm.com/efa/, indospectrum

  14. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

    2008-10-21

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  15. Special Publication No. 6, Subject: Nematoda and Nematode Diseases, Part 4: Supergenera, Genera, Species, and Subspecies: N-So. 

    E-Print Network [OSTI]

    Doss, Mildred A.; Rayburn, Jane D.; Shaw, Judith H.; Kirby, Margie D.

    1985-01-01

    During the late 19th century, a number of large marble eyes were discovered near the Athenian naval facilities at Zea. Although initially published as the eyes of ancient Greek warships, many scholars have doubted the ...

  16. Major Oak Diseases and Their Control. 

    E-Print Network [OSTI]

    Johnson, Jerral D.; Appel, David N.

    1984-01-01

    in many areas where oaks are the predominant native tree species. Research shows that much of this mortality is due to disease-causing organisms or disease complexes 10- volving environmental stress and pathogens. FOLIAR DISEASES Anthracnose (Fungus... tor nado, hurricane, severe hail or following a period of mechanical activity around oak trees. Heavy equip- ment working around trees can create large wounds. When this occurs, insects are attracted to the site and may be carrying the wilt...

  17. Diseases of Small Grains in Texas. 

    E-Print Network [OSTI]

    Atkins, I. M.; Futrell, M. C.

    1958-01-01

    Diseases - of SMALL GRAINS in cooperation with the UNITED STATES DEPARTMENT OF AGRICULTURE TEXAS AGRICULTURAL EXPERIMENT STATION R. D. LEWIS, DIRECTOR. COLLEGE STATIOKJ. TEXAS DIGEST CONTENTS 1 Diseases of small grains are important factors... and international signif- icance. The fall infection, winter survival and spring increase in South Texas of airborne pathogens, such as the cereal rusts, may endanger the small grain crops throughout Texas and other states. Diseases of wheat, which consistently...

  18. Mathematical Model Applications to Disease and Homeland ...

    E-Print Network [OSTI]

    Mathematical Model Applications to Disease and Homeland Security The events of ... but have no data or reliable information that would help in the planning or ...

  19. HANFORD THYROID DISEASE STUDY FINAL REPORT

    E-Print Network [OSTI]

    HANFORD THYROID DISEASE STUDY FINAL REPORT Study Management Team Scott Davis, Ph.D., Principal Gilman, Jennifer Sporleder, Jan Kikuchi, Bill Mullin, Liza Noonan, Chuck Wiggins, Belen Gallardo

  20. "Artificial" brains, electrical grids, and disease modeling:...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science discoveries unveiled "Artificial" brains, electrical grids, and disease modeling: Los Alamos science discoveries unveiled September 15 The event is an opportunity for...

  1. The frog inner ear: picture perfect?

    E-Print Network [OSTI]

    Mason, Matthew James; Segenhout, Johannes M.; Cobo-Cuan, Ariadna; Quiñones, Patricia M.; van Dijk, Pim

    2015-01-29

    , including 137 leopard frogs (these were believed to be Rana pipiens rather than R. sphenocephala, but this could 138 not be confirmed beyond doubt by the suppliers). Photomicrographs and three-dimensional 139 reconstructions were used to assess...

  2. Disease management Applying Stylet Oil, Sulforix or

    E-Print Network [OSTI]

    Isaacs, Rufus

    1 Disease management Applying Stylet Oil, Sulforix or Armicarb now to vines with powdery mildew will reduce disease pressure next year. Do not apply Sulforix to sulfur-sensitive grapes. Bunch rots are best controlled by leaf pulling, but application of Fungastop may help reduce sour rot. Insect management Low

  3. What You Should Know About Plant Diseases

    E-Print Network [OSTI]

    Horne, C. Wendell; Smith, Harlan E.

    1962-01-01

    lodge, the grain is shrivelled and yields are low. The disease movement is shown in figure 6. " Seedling Disease ig. 7. See, caused b - -.-!.. ~. &> dling dise; y a comp' L , ase of cot1 lex of mic 11, *L^ -1. .fore its el tter it emf...

  4. FAST OPTICAL VARIABILITY OF A NAKED-EYE BURST-MANIFESTATION OF THE PERIODIC ACTIVITY OF AN INTERNAL ENGINE

    SciTech Connect (OSTI)

    Beskin, G.; Karpov, S.; Bondar, S.; Greco, G.; Guarnieri, A.; Bartolini, C.; Piccioni, A.

    2010-08-10

    We imaged the position of the naked-eye burst, GRB080319B, before, during, and after its gamma-ray activity with sub-second temporal resolution using the TORTORA wide-field camera. The burst optical prompt emission, which reached 5.3 mag, has been detected, and its periodic optical variability has been discovered in the form of four equidistant flashes with a duration of several seconds. We also detected a strong correlation (r {approx} 0.82) between optical and gamma-ray light curves with a 2 s delay of the optical emission with respect to the gamma-ray emission. The revealed temporal structure of the optical light curve in comparison with the gamma-ray light curve can be interpreted in the framework of the model of shell collisions in the ejecta containing a significant neutron component. All observed emission features reflect the non-stationary behavior of the burst internal engine-supposedly, a hyperaccreting solar-mass black hole formed in the collapse of a massive stellar core.

  5. Intro Unicorns/Tools Trustees Audits E2E v H2E EBE+ E2E to Hand-to-Eye

    E-Print Network [OSTI]

    Stark, Philip B.

    Intro Unicorns/Tools Trustees Audits E2E v H2E EBE+ E2E + H2E E2E to Hand-to-Eye Verifiability University of Surrey Guildford, England 17­19 July 2013 #12;Intro Unicorns/Tools Trustees Audits E2E v H2E what I want to say. Statistics: Trust, but Waffle #12;Intro Unicorns/Tools Trustees Audits E2E v H2E

  6. 03/21/2006 06:00 PMHigh-Speed Surprise for Lying Eyes --Wickelgren 2006 (321): 2 --ScienceNOW Page 1 of 2http://sciencenow.sciencemag.org/cgi/content/full/2006/321/2

    E-Print Network [OSTI]

    Stocker, Alan A.

    knew that the eye does not simply record light patterns like a camera does: Instead, what people see depends greatly on past experience (a cloud looks like a boat to one person and a truck to another

  7. The implications of human metabolic network topology for disease comorbidity

    E-Print Network [OSTI]

    of different (and often disease-causing) genetic and epigenetic variations are not restricted but may spread, certain diseases, such as diabetes and obesity, or Gaucher disease and Parkinson disease, often cooccurThe implications of human metabolic network topology for disease comorbidity D.-S. Lee* , J. Park

  8. Disease Prevention in the Home Garden. 

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01

    . 12. Rotation. Avoid soil disease buildup. ?13. Insect control. Prevent virus spread. 14. Proper harvesting. Avoid storage decay. 15. Sanitation. Prevent buildup of diseased plant tissue in garden. 16. Fungicide application. Control diseases should...H to approximately 5.2; 10 Ibs. of sulfur per 1000 sq . ft. d rops the pH .5. Examp le: Ori- ginal pH 7.5; desired pH 5.5; 40 Ibs. of sulfur requ ired to adjust pH 3. Ring rot Bacterium I nfected seed pieces Introduction of Rotation and sanitation Equipment...

  9. Investigative Ophthalmology & Visual Science, Vol. 29, No. 6, June 1988 Copyright Association for Research in Vision and Ophthalmology

    E-Print Network [OSTI]

    Johnson, Mark

    , calf eyes. Eyes were immersed under silicone oil that had a density greater than water and medium meshwork and out the cut ends of the aqueous veins was trapped by the silicone oil and harvested the outflow From the *Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical

  10. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general populationAging is the primary risk factor for the majority of neurodegenerative diseases, including

  11. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general population James Parkinson first described the clinical symptoms of Parkinson's disease (PD) in his 1817 monograph

  12. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general population array of neurobiological disorders, including Parkinson's disease, epilepsy, essential tremor, Tourette

  13. Behavioral impulsivity and hallucinations : insights from Parkinson's disease

    E-Print Network [OSTI]

    Ashourian, Paymon

    2011-01-01

    Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

  14. Study of collagen structure in canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Hadian, Mojtaba

    2009-01-01

    Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs, and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans ...

  15. Epidemiology and evolution of Marek’s Disease virus 

    E-Print Network [OSTI]

    Atkins, Katherine E.

    2010-01-01

    Marek’s disease (MD) is an oncogenic disease affecting chickens and is estimated to cost the worldwide poultry industry $1-2 billion annually. The causative agent of MD, Marek’s disease virus (MDV), provides a ...

  16. HLB in Argentina: a New Disease Outbreak

    E-Print Network [OSTI]

    2014-01-01

    Vol. 1 (2014) HLB in Argentina: a New Disease Outbreak Outi,E. 6 SENASA, Bs. As. Argentina MAGyP Bs. As INTA Montecarlo,Paraná, 300 km away from Argentina’s Northeastern border. In

  17. Metabolomics reveals metabolic biomarkers of Crohn's disease

    SciTech Connect (OSTI)

    Jansson, J.K.; Willing, B.; Lucio, M.; Fekete, A.; Dicksved, J.; Halfvarson, J.; Tysk, C.; Schmitt-Kopplin, P.

    2009-06-01

    The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention.

  18. Management of cotton seedling disease complexes 

    E-Print Network [OSTI]

    Fichtner, Scott Michael

    2001-01-01

    The objective of this research was to evaluate combinations of approaches for the management of seedling diseases of cotton caused by soilborne pathogens, including the use of host resistance. Over 200 cotton lines were ...

  19. MFR PAPER 1208 Minchinia nelsoni (MSX) Disease

    E-Print Network [OSTI]

    of the disease in each of these areas has been thoroughly stud- 22 ied and reported (Haskin et aI., 1965; Andrews, 1966, 1968; Rosenfield and Sindermann, 1966; Andrews and Wood, 1967; Couch and Rosenfield, 1968; Ford

  20. Is chytridiomycosis an emerging disease in Asia?

    E-Print Network [OSTI]

    Brown, Rafe M.

    2011-01-01

    Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 26Museo Nacional de Ciencias Naturales, Madrid, Spain Abstract The disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has caused dramatic... Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 26Museo Nacional de Ciencias Naturales, Madrid, Spain Abstract The disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has caused dramatic...

  1. How should environmental stress affect the population dynamics of disease?

    E-Print Network [OSTI]

    Holt, Robert D.

    in pollution (Khan 1990), malnutrition (Beck & Levander 2000) and thermal stress from climate change (Harvell and disease in natural populations. Keywords Disease, dynamics, host, infectious, model, pollution, population

  2. ATTACHMENT 1: HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    : HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM (CBDPP) COMMITTEE CHARTER The Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP) Committee is established...

  3. Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease 

    E-Print Network [OSTI]

    Vaughan-Dark, Chelsea Ann

    2013-07-17

    This study assesses generic and disease-specific Health-Related Quality of Life (HRQOL) in children and adolescents with Inflammatory Bowel Disease (IBD). More specifically, the purpose of the study is to address the relationship between disease...

  4. Photo-environment affects disease progression in bacterial artificial chromosome (BAC) Huntington s disease mouse model

    E-Print Network [OSTI]

    HUEI-BIN, WANG,

    2015-01-01

    OF CALIFORNIA Los Angeles Photo-environment affects diseaseABSTRACT OF THE THESIS Photo-environment affects diseaseshow that inappropriate photo-environment such as constant

  5. Eye Cancer- Cobalt Treatment 

    E-Print Network [OSTI]

    Unknown

    2011-08-17

    Ductal carcinoma in situ (DCIS) has been shown to be a precursor to invasive ductal cancer (IDC). Though the progression of DCIS to IDC is believed to be an important aspect of tumor aggressiveness, prognosis and molecular markers that predict...

  6. Transgenic Mouse Model of Chronic Beryllium Disease

    SciTech Connect (OSTI)

    Gordon, Terry

    2009-05-26

    Animal models provide powerful tools for dissecting dose-response relationships and pathogenic mechanisms and for testing new treatment paradigms. Mechanistic research on beryllium exposure-disease relationships is severely limited by a general inability to develop a sufficient chronic beryllium disease animal model. Discovery of the Human Leukocyte Antigen (HLA) - DPB1Glu69 genetic susceptibility component of chronic beryllium disease permitted the addition of this human beryllium antigen presentation molecule to an animal genome which may permit development of a better animal model for chronic beryllium disease. Using FVB/N inbred mice, Drs. Rubin and Zhu, successfully produced three strains of HLA-DPB1 Glu 69 transgenic mice. Each mouse strain contains a haplotype of the HLA-DPB1 Glu 69 gene that confers a different magnitude of odds ratio (OR) of risk for chronic beryllium disease: HLA-DPB1*0401 (OR = 0.2), HLA-DPB1*0201 (OR = 15), HLA-DPB1*1701 (OR = 240). In addition, Drs. Rubin and Zhu developed transgenic mice with the human CD4 gene to permit better transmission of signals between T cells and antigen presenting cells. This project has maintained the colonies of these transgenic mice and tested the functionality of the human transgenes.

  7. Chronic beryllium disease: Diagnosis and management

    SciTech Connect (OSTI)

    Rossman, M.D.

    1996-10-01

    Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4{sup +} T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease. 21 refs.

  8. Global disease monitoring and forecasting with Wikipedia

    SciTech Connect (OSTI)

    Generous, Nicholas; Fairchild, Geoffrey; Deshpande, Alina; Del Valle, Sara Y.; Priedhorsky, Reid; Salathé, Marcel

    2014-11-13

    Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data, such as social media and search queries, are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: access logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.

  9. Global disease monitoring and forecasting with Wikipedia

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Generous, Nicholas; Fairchild, Geoffrey; Deshpande, Alina; Del Valle, Sara Y.; Priedhorsky, Reid; Salathé, Marcel

    2014-11-13

    Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data, such as social media and search queries, are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: accessmore »logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.« less

  10. 788 Plant Disease / Vol. 83 No. 9 Snow mold diseases are caused by fungi

    E-Print Network [OSTI]

    Hsiang, Tom

    788 Plant Disease / Vol. 83 No. 9 Snow mold diseases are caused by fungi that grow and attack limit the activity and number of com- petitors and antagonists of snow mold fungi, and allow these pathogens to mo- nopolize the nutrient-rich but weakened plant tissues (42). Most snow mold fungi that have

  11. An immuno-epidemiological model for Johne's disease in cattle

    E-Print Network [OSTI]

    Martcheva, Maia

    An immuno-epidemiological model for Johne's disease in cattle Maia Martcheva1 Email: maia's disease in dairy cattle, this paper illustrates a novel way to link a within-host model for Mycobacterium reproduction model. Introduction Johne's disease (JD) in dairy cattle is a chronic infectious disease

  12. Neural Modeling n The brain and its neurons

    E-Print Network [OSTI]

    Olufsen, Mette Sofie

    (nose and mouth) n Sound, vision (inner ear and eyes) n Motor neurons (Em) n Muscle cells (incl. heart Sensory neurons (Es) n Pressure, temperature, pain (skin, muscles, joints, and organs) n Smells, tastes

  13. yale environmental news spring 2006

    E-Print Network [OSTI]

    & Environmental Studies, and the Yale Institute for Biospheric Studies #12;eye nostrils tongue and roof of mouth skull "cheeks" ear skeleton skin texture cloaca hand and wrist shoulder and elbow foot and ankle muscles

  14. A system for efficient neural stimulation with energy recovery

    E-Print Network [OSTI]

    Kelly, Shawn Kevin, 1973-

    2004-01-01

    An analog VLSI-based low-power neural tissue stimulator is presented as a part of the MIT and Massachusetts Eye and Ear Infirmary Retinal Implant Project to develop a prosthesis for restoring some useful vision to patients ...

  15. Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4D-10080811RCT on radio.jpg Gallery: U Canyon -- D10 Tank Title: Keywords: D10 Tank, U Canyon, grouting, demolition Description: August 8: With an eye on the clock and an ear to...

  16. interdisciplinary Glyphosate, pathways to modern diseases II

    E-Print Network [OSTI]

    Seneff, Stephanie

    rashes, depression, and nutrient deficiencies. Usually, but not always, a strict gluten-free diet caninterdisciplinary Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North

  17. ISSUE 58 APRIL 2009 Will coeliac disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 58 APRIL 2009 Will coeliac disease always mean gluten-free? Pen-pushers Meet the winning is to deliver a free, Darwin-inspired experiment to every schoolchild in the country. For primary schools, we of the Wellcome Trust Wellcome News Wellcome News is published four times a year and is available free of charge

  18. Centers for Disease Control and Prevention (CDC)

    E-Print Network [OSTI]

    and Terrorism and Director of Global Health Activities for the Division of Environmental Hazards and Health based environmental health assessments #12;Government Agencies Visited · The United States AgencyCenters for Disease Control and Prevention (CDC) National Center for Environmental Health CDC

  19. DISEASE-SPECIFIC PROBABILISTIC BRAIN ATLASES

    E-Print Network [OSTI]

    Thompson, Paul

    algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining School of Medicine, Los Angeles, CA 2 Alzheimer's Disease Center, UCLA School of Medicine, Los Angeles Westwood Plaza, Los Angeles, CA 90095-1769 Phone: (310) 206-2101 Fax: (310) 206-5518 E-mail: thompson

  20. Injury vs Disease Lifestyles of pathogens

    E-Print Network [OSTI]

    Nowak, Robert S.

    of plant disease Nematodes alone cost ~$100 billions worldwide In the US, yearly cost ~ $15 billions #12 of temperature 3 Days After #12;#12;Effects of wind Mostly dispersal of pathogens In some cases, wind can prevent the development of new infections because it dries the surface of plants Wind can cause injury

  1. Injury vs Disease Lifestyles of pathogens

    E-Print Network [OSTI]

    Nowak, Robert S.

    In the US, yearly cost ~ $15 billions #12;4/29/2015 15 Impacts of plant disease In a worldwide scale 27 of wind Mostly dispersal of pathogens In some cases, wind can prevent the development of new infections because it dries the surface of plants Wind can cause injury (mechanical abrasion) Effects of temperature

  2. Genetically Determined Height and Coronary Artery Disease

    E-Print Network [OSTI]

    Nelson, Christopher P.; Hamby, Stephen E.; Saleheen, Danish; Hopewell, Jenna C.; Zeng, Lingyao; Assimes, Themistocles L.; Kanoni, Stavroula; Willenborg, Christina; Burgess, Stephen; Amouyel, Philippe; Anand, Sonia; Blankenberg, Stefan; Boehm, Bernhard O.; Clarke, Robert J.; Collins, Rory; Dedoussis, George; Farrall, Martin; Franks, Paul W.; Groop, Leif; Hall, Alistair S.; Hamsten, Anders; Hengstenberg, Christian; Hovingh, G. Kees; Ingelsson, Erik; Kathiresan, Sekar; Kee, Frank; König, Inke R.; Kooner, Jaspal; Lehtimäki, Terho; März, Winifred; McPherson, Ruth; Metspalu, Andres; Nieminen, Markku S.; O'Donnell, Christopher J.; Palmer, Colin N.A.; Peters, Annette; Perola, Markus; Reilly, Muredach P.; Ripatti, Samuli; Roberts, Robert; Salomaa, Veikko; Shah, Svati H.; Schreiber, Stefan; Siegbahn, Agneta; Thorsteinsdottir, Unnur; Veronesi, Giovani; Wareham, Nicholas J.; Willer, Cristen J.; Zalloua, Pierre A.; Erdmann, Jeanette; Deloukas, Panos; Watkins, Hugh; Schunkert, Heribert; Danesh, John; Thompson, John R.; Samani, Nilesh J.

    2015-04-23

    of Tampere, Tampere (T.L.), and the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital (M.S.N.), Department of Chronic Disease Prevention, National Institute for Health and Welfare (M.P., V.S.), and Hjelt Institute The New...

  3. 3301DEVELOPMENT AND DISEASE RESEARCH ARTICLE INTRODUCTION

    E-Print Network [OSTI]

    Gibson, Matt

    smooth muscle cells (SMC) and SM pathology is associated with several diseases, including asthma, lung the urinary bladder, and a failure of this activity causes `functional' flow impairment leading to urinary tract may be an important primary cause of functional obstruction and hydronephrosis. Between mouse

  4. Treatment of Anthrax Disease Frequently Asked Questions

    SciTech Connect (OSTI)

    Judd, Kathleen S.; Young, Joan E.; Lesperance, Ann M.; Malone, John D.

    2010-05-14

    This document provides a summary of Frequently Asked Questions (FAQs) on the treatment of anthrax disease caused by a wide-area release of Bacillus anthracis spores as an act bioterrorism. These FAQs are intended to provide the public health and medical community, as well as others, with guidance and communications to support the response and long-term recovery from an anthrax event.

  5. ISSUE 55 JULY 2008 Genes and disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 55 JULY 2008 FUNDING Genes and disease In this issue... FUNDING AND UPDATES 2­5 Project building, in Kenya, South Africa, Uganda and elsewhere in Africa (see page 5). The largest ever study. The Institute will devote a large part of its high-throughput genotyping pipeline, headed by Dr Panos Deloukas

  6. DISEASES OF AQUATIC ORGANISMS Dis Aquat Org

    E-Print Network [OSTI]

    Harvell, Catherine Drew

    and disease in Mexico J. R. Ward1,*, K. L. Rypien1 , J. F. Bruno2 , C. D. Harvell1 , E. Jordán-Dahlgren3 , K Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3300, USA 3

  7. Disease Prediction Models and Operational Readiness

    SciTech Connect (OSTI)

    Corley, Courtney D.; Pullum, Laura L.; Hartley, David M.; Benedum, Corey M.; Noonan, Christine F.; Rabinowitz, Peter M.; Lancaster, Mary J.

    2014-03-19

    INTRODUCTION: The objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information for decision makers to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews. First, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. Second, we considered models involving pathogens of concern as determined by the US National Select Agent Registry (as of June 2011). Methods: We searched dozens of commercial and government databases and harvested Google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, The publication date of search results returned are bound by the dates of coverage of each database and the date in which the search was performed, however all searching was completed by December 31, 2010. This returned 13,767 webpages and 12,152 citations. After de-duplication and removal of extraneous material, a core collection of 6,503 items was established and these publications along with their abstracts are presented in a semantic wiki at http://BioCat.pnnl.gov. Next, PNNL’s IN-SPIRE visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model resulting in the selection of 54 documents that matched the criteria resulting Ten of these documents, However, dealt purely with disease spread models, inactivation of bacteria, or the modeling of human immune system responses to pathogens rather than predicting disease events. As a result, we systematically reviewed 44 papers and the results are presented in this analysis.

  8. Laterality of Motor Symptom Onset, Disease Progression, and Cognition in Parkinson's Disease

    E-Print Network [OSTI]

    Chau, Phuong My

    2010-08-31

    The current study examined whether laterality of initial motor symptom onset (left-sided onset vs. right-sided onset) in Parkinson's disease (PD) would predict the pattern and/or severity of cognitive deficits measured at ...

  9. Disease resistance and performance of blended populations of creepi 

    E-Print Network [OSTI]

    Abernathy, Scott David

    1999-01-01

    Plant diseases are a major problem on creeping bentgrass greens and can significantly decrease putting quality. Blended populations comprised of two or more cultivars within the same species have been utilized to decrease disease development...

  10. Goal-directed Behaviour & Apathy in Parkinson's Disease 

    E-Print Network [OSTI]

    Cox, Simon

    2009-11-26

    Apathy has been described as a highly-prevalent symptom of Parkinson's disease that has a significant effect upon quality of life, even when the motor symptoms of the disease are taken into account.

  11. Characterization of a Drosophila model of Huntington's disease

    E-Print Network [OSTI]

    Lee, Wyan-Ching Mimi

    2006-01-01

    Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

  12. Mycosphaerella species causing leaf disease in South African Eucalyptus plantations

    E-Print Network [OSTI]

    Mycosphaerella species causing leaf disease in South African Eucalyptus plantations Gavin C. HUNTER Eucalyptus plantations provide an important source of hardwood for forestry industries, worldwide. Several species of Mycosphaerella are associated with a destructive Eucalyptus leaf disease known

  13. Women and Heart Disease: Neglected Directions for Future Research

    E-Print Network [OSTI]

    Barrett-Connor, Elizabeth

    2009-01-01

    009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

  14. Endemic models for the spread of infectious diseases with arbitrarily ...

    E-Print Network [OSTI]

    SIAM (#1) 1035 1999 Jan 20 12:53:14

    2000-10-03

    have general length distributions and disease survival functions, the different time ..... In order to describe the duration of the various stages and the related disease ...... Approaches to Problems in Resource Management and Epidemiology, ...

  15. Role of the hedgehog signalling pathway in inflammatory bowel disease 

    E-Print Network [OSTI]

    Lees, Charles William

    2009-01-01

    Introduction. The inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), are common in Western Europe (200-400 cases /100,000) and associated with substantial morbidity, although mortality ...

  16. Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms Molecular mechanisms of aging-related neurodegenerative diseases: emerging views

    E-Print Network [OSTI]

    Breitling, Rainer

    , including Parkinson's disease, polyglutamine expansion diseases and Alzheimer's disease, are associated used to model these diseases and high throughput genetic screens using these models have led-analysis #12;3 Introduction Several age-related neurodegenerative diseases, including Parkinson's disease

  17. (See reverse side) Information about Meningococcal Disease and Vaccination

    E-Print Network [OSTI]

    Dennett, Daniel

    is infected and is coughing or sneezing. Who is at most risk for getting meningococcal disease? High

  18. Observational Accuracy of Variable Stars, Novae and Supernovae from Naked Eye to General Relativistic Standard: a Balance over Thousand SGQ Observations Sent to AAVSO

    E-Print Network [OSTI]

    Sigismondi, Costantino

    2015-01-01

    The theory of General Relativity deals with very accurate measurements that show significant divergences from Newtonian predictions only with speeds near to the velocity of light. An introduction for educational purposes, based on naked eye photometry, deals with the radiation near collapsing star's shells like novae and supernovae. The theme of accuracy is drafted from entry level observations to the precision of professional data, often of public domain on the web. Thousand observations of variable stars, included the type 1a SN2014J, the Nova Del 2013 and the Nova Cen 2013, sent to the AAVSO by the author, with SGQ code, during the period 1998-2015 are analyzed to increase the photometric accuracy, in the occasion of the International Year of Light 2015.

  19. Exploring Disease Transmission On Networks with Winfried Just

    E-Print Network [OSTI]

    Just, Winfried

    the relevant contact network, depends on the particular disease. Think of the flu vs. a computer virus vs of disease transmission Infectious diseases are caused by pathogens (such as viruses, bacteria, fungi identical. Such models can be embodied in computer code as agent-based models. Winfried Just and Ying Xin

  20. Disease transmission by cannibalism: rare event or common occurrence?

    E-Print Network [OSTI]

    Antonovics, Janis

    Disease transmission by cannibalism: rare event or common occurrence? Volker H. W. Rudolf Cannibalism has been documented as a possible disease transmission route in several species, including humans. However, the dynamics resulting from this type of disease transmission are not well understood. Using

  1. Neurobiology of Disease Parkin Directly Modulates 26S Proteasome Activity

    E-Print Network [OSTI]

    Lübbert, Hermann

    . Introduction Parkinson's disease (PD) is a major neurodegenerative disease characterized by the degenerationNeurobiology of Disease Parkin Directly Modulates 26S Proteasome Activity Ji Won Um,1 Eunju Im,1-University Bochum, D-44780 Bochum, Germany, and 4Biofrontera Bioscience GmbH, D-51377 Leverkusen, Germany Parkinson

  2. Neuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response

    E-Print Network [OSTI]

    Sulzer, David

    in a wide range of toxin-based, inflammatory and genetic Parkinson's disease animal models. KeywordsNeuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response or a Step neuroin- flammatory processes are exacerbated in Parkinson's disease, including glial- mediated reactions

  3. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases

    E-Print Network [OSTI]

    Bellugi, Ursula

    such as Parkinson's disease and amyotrophic lateral sclerosis where patients' cells have been successfully repro the end-stage of the disease. Mouse models provide a means to mimic human genetic forms of diseases. Owingto tech- nical challenges, species differences and genetic background, even neurologic

  4. Emerging infectious diseases of plants: pathogen pollution, climate change

    E-Print Network [OSTI]

    Schweik, Charles M.

    Emerging infectious diseases of plants: pathogen pollution, climate change and agrotechnology, Boston, MA 02115, USA Emerging infectious diseases (EIDs) pose threats to conservation and public health a series of emerging plant diseases. We include EIDs of cultivated and wild plants, some of which

  5. Understanding Equine Strangles: Signs of Disease, Management and Prevention1

    E-Print Network [OSTI]

    Watson, Craig A.

    in 1251. The infection is highly contagious in horse populations and can recur on farms with previous outbreaks of the disease. It is one of the most commonly diagnosed contagious diseases of the horse signs of infection. Complications of Disease Fortunately, although strangles is highly contagious

  6. A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN

    E-Print Network [OSTI]

    A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN BY R. R. RUCKER, W. J. WHIPPLE, J. R A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN By R. R. Rucker, W. J. Whipple, J. R. Parvin and C. A #12;A CONTAGIOUS DISEASE OF SALMON, POSSIBLY OF VIRUS ORIGIN By R. R. Rucker,! Fishery Research

  7. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  8. Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn’s Disease 

    E-Print Network [OSTI]

    Phillips, Anne Mairead

    2011-07-05

    The inflammatory bowel diseases (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract. Their aetiology is not fully understood but is thought ...

  9. An investigation of the genetic determinants of succeptibility and disease behavoir in early onset Inflammatory Bowel Disease in Scottish children. 

    E-Print Network [OSTI]

    Russell, Richard K

    2008-01-01

    A series of investigations examining the importance of genetic factors in the development of the inflammatory bowel diseases (IBD) namely Crohn’s disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC) has ...

  10. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01

    in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang •

  11. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01

    predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

  12. Understanding diseases at a molecular level

    SciTech Connect (OSTI)

    Rosev, Tatjana K [Los Alamos National Laboratory

    2008-01-01

    A group of scientists at Los Alamos National Laboratory in 2008 successfully pioneered a microscope able to track protein-sized, hard to see particles in three dimensions. The 3D Tracking Microscope, designed and developed by James H. Werner, Guillaume A. Lessard, Nathan Wells and Peter M. Goodwin of LANL's Center for Integrated Nanotechnologies, won a 2008 R&D 100 award. The team's invention is a unique confocal 3D tracking microscope capable of following the motion of nanometer-sized objects, such as individual molecules, quantum dots, organic fluorophores and single green fluorescent proteins as they zoom through three-dimensional space at rates faster than many intracellular transport processes. The 3D tracking microscope can follow the transport of nanometer-sized particles at micrometer per second rates. This enables researchers to follow individual protein, ribonucleic acid (RNA), or deoxyribonucleic acid (DNA) motion throughout the full three-dimensional volume of a cell to discover the path a particular biomolecule takes, the method it employs to get there and the specific proteins it may be interacting with along the way. In addition to applications in molecular spectroscopy and materials research, the 3D tracking microscope is a powerful tool primarily in the fields of cellular biology and biomedical research, Werner said. 'The 3D tracking microscope will advance our understanding of the molecular basis and kinetics of many diseases, such as cancer, diabetes, or muscular dystrophy,' he said. 'We anticipate the microscope will become a valuable weapon in the arsenal of biomedical researchers who are fighting to find cures for cancer, heart disease and other protein or DNA-based diseases.'

  13. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  14. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's pneumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  15. Chronic Beryllium Disease Prevention Program Report

    SciTech Connect (OSTI)

    Lee, S

    2012-03-29

    This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

  16. Automated diagnostic kiosk for diagnosing diseases

    DOE Patents [OSTI]

    Regan, John Frederick; Birch, James Michael

    2014-02-11

    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  17. Optical detection dental disease using polarized light

    DOE Patents [OSTI]

    Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Fried, Daniel (San Francisco, CA)

    2003-01-01

    A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.

  18. PERIORAL BIOMECHANICS, KINEMATICS, AND ELECTROPHYSIOLOGY IN PARKINSON'S DISEASE

    E-Print Network [OSTI]

    Chu, Shin Ying

    2010-11-21

    This investigation quantitatively characterized the orofacial biomechanics, labial kinematics, and associated electromyography (EMG) patterns in individuals with Parkinson's disease (PD) as a function of anti-PD medication ...

  19. Structure of the Newcastle disease virus hemagglutinin-neuraminidase...

    Office of Scientific and Technical Information (OSTI)

    of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk Citation Details In-Document Search Title: Structure of the Newcastle...

  20. Proteins' Amazing Origami Powers: Insight for Potential Disease...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Senior Writer, Office of Science What are the key facts? Better knowledge of protein folding could in turn provide more insight into the diseases associated with malformed...

  1. Genomics of emerging infectious disease: A PLoS collection.

    E-Print Network [OSTI]

    Eisen, Jonathan A; MacCallum, Catriona J

    2009-01-01

    Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

  2. Psoriasis disease severity affects patient satisfaction with treatment

    E-Print Network [OSTI]

    Korman, Neil J; Zhao, Yang; Lu, Jackie; Tran, Mary Helen

    2015-01-01

    among patients with psoriasis and psoriatic arthritis in thefindings from the National Psoriasis Foundation surveys,J. Mechanism of disease: psoriasis. N Engl J Med. 2009;361(

  3. Recombinant herpes simplex virus useful for treating neoplastic disease

    DOE Patents [OSTI]

    Whitley, Richard J.; Roizman, Bernard

    2010-06-29

    Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.

  4. AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS...

    Office of Scientific and Technical Information (OSTI)

    Converting energy to medical progress nuclear medicine NONE 62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS; NUCLEAR MEDICINE; PATIENTS; RADIATION...

  5. Bacteria Associated With Colitis and Inflammatory Bowel Disease

    E-Print Network [OSTI]

    Ye, Jingxiao

    2009-01-01

    bowel diseases: antibiotics, probiotics, and prebiotics."clinical trial of probiotics (Lactobacillus johnsonii, LA1)Besides antibiotics, probiotics might also be a potential

  6. A Study of Interstellar Gas and Stars in the Gravitationally Lensed Galaxy `The Cosmic Eye' from Rest-Frame Ultraviolet Spectroscopy

    E-Print Network [OSTI]

    Quider, Anna M; Pettini, Max; Steidel, Charles C; Stark, Daniel P

    2009-01-01

    We report the results of a study of the rest-frame UV spectrum of the Cosmic Eye, a luminous Lyman break galaxy at z=3.07331 gravitationally lensed by a factor of 25. The spectrum, recorded with the ESI spectrograph on the Keck II telescope, is rich in absorption features from the gas and massive stars in this galaxy. The interstellar absorption lines are resolved into two components of approximately equal strength and each spanning several hundred km/s in velocity. One component has a net blueshift of -70 km/s relative to the stars and H II regions and presumably arises in a galaxy-scale outflow similar to those seen in most star-forming galaxies at z = 2-3. The other is more unusual in showing a mean redshift of +350 km/s relative to the systemic redshift; possible interpretations include a merging clump, or material ejected by a previous star formation episode and now falling back onto the galaxy, or more simply a chance alignment with a foreground galaxy. In the metal absorption lines, both components onl...

  7. Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model

    E-Print Network [OSTI]

    Treusch, Sebastian

    2011-01-01

    Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

  8. Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?

    E-Print Network [OSTI]

    Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

    2011-01-01

    case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

  9. Fish oil can help reduce deaths from heart disease,

    E-Print Network [OSTI]

    Shen, Jun

    Fish oil can help reduce deaths from heart disease, according to new evidence reports announced- ute to heart disease. The review also found other evidence indicating that fish oil can help lower in knowledge." Continued, page 2... Evidence Reports Confirm Benefits of Fish Oil Elizabeth Yetley, PhD Joins

  10. Harnessing plasticity to understand learning and treat disease

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Harnessing plasticity to understand learning and treat disease Michael P. Kilgard The University, USA A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies sug- gest that cortical map plasticity is typically a transient phase that improves

  11. Epidemiology / pidmiologie Climate change and plant diseases in Ontario

    E-Print Network [OSTI]

    Boland, Greg J.

    Epidemiology / Épidémiologie Climate change and plant diseases in Ontario G.J. Boland, M.S. Melzer in Ontario will significantly affect the occurrence of plant diseases in agriculture and forestry management plans. Adaptations in agriculture and forestry have been occurring in Ontario for over 100 years

  12. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  13. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  14. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease

    E-Print Network [OSTI]

    Sulzer, David

    State Psychiatric Institute, New York City, NY 10032, USA Parkinson's disease arises from geneticMultiple hit hypotheses for dopamine neuron loss in Parkinson's disease David Sulzer Departments features. Although many genetic mutations have been suggested as causes or risk factors for Parkinson

  15. Ash dieback disease www.forestry.gov.uk/planthealth

    E-Print Network [OSTI]

    Ash dieback disease www.forestry.gov.uk/planthealth Pest Alert Distribution In Britain, most of the outbreaks of ash dieback disease in the natural environment are confined to East Anglia and Kent, although a small number of outlying cases have been confirmed in northeast England and Scotland. Common ash

  16. Chronic Beryllium Disease Prevention Environment, Safety, Health, and Quality Division

    E-Print Network [OSTI]

    Wechsler, Risa H.

    Chronic Beryllium Disease Prevention Program Environment, Safety, Health, and Quality Division SLAC-I-730-0A09M-001-R003 24 September 2013 #12;Publication Data This document was developed by the Beryllium program and published by ESHQ Publishing. Document Title: Chronic Beryllium Disease Prevention Program

  17. Economic Consideration of Mitigation of Foreign Animal Disease Introduction *

    E-Print Network [OSTI]

    McCarl, Bruce A.

    Economic Consideration of Mitigation of Foreign Animal Disease Introduction * Levan Elbakidze, Bruce A. McCarl Department of Agricultural Economics National Center for Foreign Animal and Zoonotic Disease Defense (FAZDD), Texas A&M University, College Station TX, USA The economic implications

  18. Motor signs during the course of Alzheimer disease

    E-Print Network [OSTI]

    to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits

  19. Research Fund for the Prevention and Treatment of Kidney Disease

    E-Print Network [OSTI]

    Weber, David J.

    and economic costs associated with these diseases. UMMC accommodates one million patient visits a year With a reputation for innovation and technical and surgical excellence, the UMSOM Division of Transplantation is one global cost for treatment of kidney disease in terms of dialysis and transplantation over the next decade

  20. Asbestos-related pulmonary disease in boilermakers

    SciTech Connect (OSTI)

    Demers, R.Y.; Neale, A.V.; Robins, T.; Herman, S.C. )

    1990-01-01

    Boilermakers are skilled building tradesmen who construct, repair, and dismantle boilers. The present study reports on the evaluation of members of a Michigan boilermaker's union for the presence of signs and symptoms of chronic pulmonary disease. Study variables included standardized evaluations of chest x-ray findings, pulmonary function testing, physical examination, and respiratory symptoms. An overall participation rate of 69% was achieved. A non-participant survey identified no significant differences between participants and non-participants in dyspnea, cough, age, or smoking history. Among participants with greater than 20 years experience in the trade, the mean FVC was 91% of predicted; the FEV1 was 86% of predicted; 25% showed at least a 1/0 profusion of interstitial markings on chest x-ray; 30% had bilateral pleural abnormalities; and 52% had audible inspiratory rales on physical examination. Forced vital capacity and forced expiratory volume at one second both decreased with years in the trade. Chest x-ray findings of interstitial fibrosis and pleural plaques were related to ten or more years in the trade, as were respiratory symptoms of pulmonary rales, wheeze, and dyspnea.

  1. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK

    E-Print Network [OSTI]

    Sulzer, David

    and 2 Department of Neurology, Center for Parkinson's Disease and Other Movement Disorders, Columbia Disease, polyglutamine disease (CAG repeat), and Parkinson disease (10). Ã To whom correspondence shouldAutophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and m

  2. Commercial Pecans: Controlling Rosette, Diseases and Zinc Deficiency 

    E-Print Network [OSTI]

    Lee, Thomas A.; Krausz, Joseph P.

    2006-04-13

    to be healthy and vigor- ous and for nut quality and yield to be satisfactory, producers must establish sound disease-management programs. Producers can pre- vent losses from diseases and insuff_i cient zinc by implementing ef_fective grove management... fall. Although the foliage is mature and no longer susceptible to the scab fun- gus, the shucks surrounding the nuts are immature and vulnerable to late-season infections. Factors inf_l uencing disease development As you develop a spray program...

  3. PrPSc complexity in different forms of Creutzfeldt-Jakob disease identified using biochemical approaches 

    E-Print Network [OSTI]

    Choi, Young Pyo

    2010-01-01

    Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative diseases affecting humans and animal species. Prion diseases are characterized by the conversion of the host encoded ...

  4. HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF ENERGY CONSERVATION IN RESIDENTIAL BUILDINGS

    E-Print Network [OSTI]

    Budnitz, R.J.

    2011-01-01

    Buildings H M N DISEASE FROM RADON EXPOSURES: U A THE IMPACTVent 78-6 HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OFof conservation measures on radon levels, and the disease

  5. Tackling Africa's chronic disease burden: from the local to the global

    E-Print Network [OSTI]

    de-Graft Aikins, Ama; Unwin, Nigel; Agyemang, Charles; Allotey, Pascale; Campbell, Catherine; Arhinful, Daniel

    2010-04-19

    Abstract Africa faces a double burden of infectious and chronic diseases. While infectious diseases still account for at least 69% of deaths on the continent, age specific mortality rates from chronic diseases as a whole are actually higher in sub...

  6. Speaker for Nov. 1 Lecture to Discuss Deadliest Viral Diseases...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    These studies have led her from the U.S. Centers for Disease Control and Prevention to Lyon, France, where she was instrumental in designing, constructing and making operational a...

  7. Interpreting noncoding genetic variation in complex traits and human disease

    E-Print Network [OSTI]

    Kellis, Manolis

    Association studies provide genome-wide information about the genetic basis of complex disease, but medical research has focused primarily on protein-coding variants, owing to the difficulty of interpreting noncoding ...

  8. Striatal origin of the pathologic beta oscillations in Parkinson's disease

    E-Print Network [OSTI]

    Boyden, Edward Stuart

    Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...

  9. Superspreading and the impact of individual variation on disease emergence

    E-Print Network [OSTI]

    Getz, Wayne M.

    1 Superspreading and the impact of individual variation on disease emergence Supplementary.................................................................................................................................. 4 1.1 Factors contributing to variation in infectiousness 2.2.2 Parameter estimation from mean and proportion of zeros .................................... 8

  10. Enhancing synaptogenesis in diseases characterized by deficiencies in brain synapses

    E-Print Network [OSTI]

    Wurtman, Richard Jay

    The loss of hippocampal and cortical synapses, resulting from impaired synaptogenesis, accelerated synaptic degeneration, or both, is one of the earliest neuropathologic findings in Alzheimer’s Disease and is the finding ...

  11. Introduction Multiple sclerosis (MS) is an inflammatory disease of the

    E-Print Network [OSTI]

    Strominger, Jack L.

    Introduction Multiple sclerosis (MS) is an inflammatory disease of the CNS affecting 0 the frequency of relapses by 30% in relapsing-remitting multiple sclerosis (MS) patients. In the present study

  12. Computational and experimental studies of collagen and related diseases

    E-Print Network [OSTI]

    Yang, Chen, M. Eng. Massachusetts Institute of Technology

    2005-01-01

    Collagen is the most abundant proteins in mammals, and collagen degradation is a process that may be associated with many diseases. In this research we use collagen-like peptides that model both cleavage and noncleavage ...

  13. A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE 

    E-Print Network [OSTI]

    Newton, Billy W.

    2010-01-16

    Alcoholic steatosis (AS) is the initial pathology associated with early stage alcoholic liver disease and is characterized by the accumulation of fat in the liver. AS is considered clinically benign as it is reversible, ...

  14. Peptide immunotherapy in models of allergic airways disease 

    E-Print Network [OSTI]

    MacKenzie, Karen Joan

    2011-11-25

    Allergen-reactive CD4+ T cells are implicated in the pathogenesis of allergic disease. Peptide immunotherapy (PIT) involves therapeutic administration of short immunodominant peptides from within the protein allergen to ...

  15. Ecologic niche modeling and spatial patterns of disease transmission

    E-Print Network [OSTI]

    Peterson, A. Townsend

    2006-12-01

    Ecologic niche modeling (ENM) is a growing field with many potential applications to questions regarding the geography and ecology of disease transmission. Specifically, ENM has the potential to inform investigations concerned ...

  16. Biological studies and characterization of the High Plains Disease pathogen 

    E-Print Network [OSTI]

    Mirabile, Joanna

    2001-01-01

    High Plains Disease (HPD), which is a recently recognized affliction causing up to 80% yield losses in corn and wheat, has been suspected to be of viral origin, however no clear evidence existed to validate this claim. ...

  17. Parenting styles, peer influences, and adolescent cardiovascular disease risk factors 

    E-Print Network [OSTI]

    Tramm, Amy Bishop

    2000-01-01

    Parenting and friendship styles were examined as indicators for obesity and risk of cardiovascular disease in 54 Texas adolescents. This study investigated the relationship between parental and peer influences on obesity ...

  18. Cognitive change in motor neurone disease : evidence of orbitofrontal dysfunction 

    E-Print Network [OSTI]

    McNeill, Ewan

    2006-01-01

    This study examines the presence of cognitive changes in amyotrophic lateral sclerosis (ALS), a subtype of motor neurone disease. Past research has shown executive dysfunction in patients with ALS and frontotemporal ...

  19. Marek’s disease virus pathogenesis and latency 

    E-Print Network [OSTI]

    Hunter, Gillian

    2012-11-30

    Marek’s Disease virus (MDV) is a highly contagious, widespread and persistent neoplastic ?-herpesvirus causing extensive lymphoblastic tumours in chickens. The virus is shed in feather dust and spread through inhalation. ...

  20. Nature of language impairment in motor neurone disease 

    E-Print Network [OSTI]

    Rewaj, Phillipa Jane

    2014-07-01

    Background: Language impairment associated with Motor Neurone Disease (MND) has been documented since the late 19th century, yet little is understood about the pervasiveness or nature of these deficits. The common clinical ...

  1. GUIDE FOR IDENTIFICATION OF IMPORTANT DISEASES IN STRAWBERRY IN CALIFORNIA

    E-Print Network [OSTI]

    Ullrich, Paul

    GUIDE FOR IDENTIFICATION OF IMPORTANT DISEASES IN STRAWBERRY IN CALIFORNIA Anthracnose Angular Leaf on the underside of the leaf is one of the most recognizable signs of bacterial infection on strawberry leaves

  2. Disease marketing and patient coping : a research study

    E-Print Network [OSTI]

    Lau, Hew Mun

    2012-01-01

    BACKGROUND: There is a high prevalence of disease marketing actions in the United States that are targeted towards patients with chronic illness. However, no study has assessed the direct effects of these marketing actions ...

  3. Transforming South–South Technical Support to Fight Noncommunicable Diseases

    E-Print Network [OSTI]

    Shakow, Aaron D.A.

    At the UN High-Level Meeting on non-communicable diseases (NCD) in September 2011, each member state was challenged to create a multisectoral national policy and plan for the prevention and control of non-communicable ...

  4. Polyamine pathway contributes to the pathogenesis of Parkinson disease

    E-Print Network [OSTI]

    Lewandowski, Nicole M.

    The full complement of molecular pathways contributing to the pathogenesis of Parkinson disease (PD) remains unknown. Here we address this issue by taking a broad approach, beginning by using functional MRI to identify ...

  5. Interactive Whole-Heart Segmentation in Congenital Heart Disease

    E-Print Network [OSTI]

    Pace, Danielle Frances

    We present an interactive algorithm to segment the heart chambers and epicardial surfaces, including the great vessel walls, in pediatric cardiac MRI of congenital heart disease. Accurate whole-heart ...

  6. Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease

    E-Print Network [OSTI]

    Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease Christian Habeck January 2008 Available online 14 February 2008 We performed univariate and multivariate discriminant univariate and multivariate analyses produced markers with high classification accuracy in the derivation

  7. Food, Poverty and Epidemic Disease, Edinburgh: 1840-1850 

    E-Print Network [OSTI]

    MacGillivray, Neil

    2004-01-01

    The thesis first examines the link between nutrition and disease, focusing on the poor of Edinburgh during the 184Os, a time of economic depression and food shortage. The development of nutritional science and the level ...

  8. Host nutrition and infectious disease: an ecological view

    E-Print Network [OSTI]

    Smith, Val H.; Jones II, Tyrees P.; Smith, Marilyn S.

    2005-06-01

    Nutrition is typically discussed in terms of maintaining a proper diet and avoiding nutrient deficiency diseases. However, nutrition can also be viewed from an ecological standpoint: mammalian hosts and their pathogens ...

  9. Strategic Global Alliances in Vaccine Development and Disease Control

    E-Print Network [OSTI]

    Schnaufer, Achim

    Strategic Global Alliances in Vaccine Development and Disease Control Dr Sadhana Sharma BBSRC · UK veterinary vaccinology network · Global veterinary vaccinology alliance #12;3 COORDINATION public engagement on bioscience What we do: #12;"Global Strategic Alliances for the Coordination

  10. Neuroimaging of Discourse Processing in Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Wang, Clarice

    2011-12-31

    Detection of very early stages of Alzheimer's Disease (AD) has been an area of difficulty for researchers due to confounds with age. Prose recall has been suggested as a diagnostically sensitive test of episodic memory declines in AD; however...

  11. Timing of testing and treatment for asymptomatic diseases

    SciTech Connect (OSTI)

    K?rk?zlar, Eser; Faissol, Daniel M.; Griffin, Paul M.; Swann, Julie L.

    2010-07-01

    Many papers in the medical literature analyze the cost-effectiveness of screening for diseases by comparing a limited number of a priori testing policies under estimated problem parameters. However, this may be insufficient to determine the best timing of the tests or incorporate changes over time. In this paper, we develop and solve a Markov Decision Process (MDP) model for a simple class of asymptomatic diseases in order to provide the building blocks for analysis of a more general class of diseases. We provide a computationally efficient method for determining a cost-effective dynamic intervention strategy that takes into account (i) the results of the previous test for each individual and (ii) the change in the individual’s behavior based on awareness of the disease. We demonstrate the usefulness of the approach by applying the results to screening decisions for Hepatitis C (HCV) using medical data, and compare our findings to current HCV screening recommendations.

  12. Medicating race : heart disease and durable preoccupations with difference

    E-Print Network [OSTI]

    Pollock, Anne, 1975-

    2007-01-01

    This dissertation is an examination of intersections of race, pharmaceuticals, and heart disease over the course of the 20th century and today. Each of these parts has had a dynamic history, and when they are invoked ...

  13. Mechanisms of disease pathogenesis in Spinal Muscular Atrophy 

    E-Print Network [OSTI]

    Mutsaers, Chantal

    2014-06-28

    Low levels of survival motor neuron (SMN) protein cause the autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA), through mechanisms that are poorly defined. SMN protein is ubiquitously expressed, ...

  14. Field Diseases of the Sweet Potato in Texas. 

    E-Print Network [OSTI]

    Taubenhaus, J. J. (Jacob Joseph)

    1919-01-01

    the diseases of the sweet potato. Instead, the corrosive sub: mate treatment should be resorted to because of its efficiency as a fun$ cide arid because of the stimulating effect which it exerts on the resul ing sprouts. After carefully selecting the seed... sweet potatoes for shape (Fig. 1) and discarding all the "shoe strings" (Fig. 2), they should be disinfected with corrosive sublimate solution. This treatment aims at killing the spores of the various disease producing organisms which adhere...

  15. Engineering disease resistance with pectate lyase-like genes

    DOE Patents [OSTI]

    Vogel, John; Somerville, Shauna

    2005-03-08

    A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

  16. Characterization of Resistance to Black Spot Disease of Rosa Spp. 

    E-Print Network [OSTI]

    Dong, Qianni

    2014-12-01

    Young-Ki Jo Joshua Yuan Head of Department, Daniel R. Lineberger December 2014 Choose an item. Choose an item. Major Subject: Horticulture Copyright.... These trials typically last 2-3 years to ensure sufficient disease pressure to properly assess the resistance of the plants (Carlson-Nilsson, 2000; Noack, 2003; Shupert, 2005). Lab based detached leaf 4 assay (DLA) is a tool for observing disease...

  17. The inflammatory response in transgastric surgery: gastric content leak leads to localized inflammatory response and higher adhesive disease

    E-Print Network [OSTI]

    2010-01-01

    response and higher adhesive disease Sonia L. Ramamoorthy Æin?ammatory markers, adhesive disease, and morbidity.cantly higher rate of adhesive disease in the SG compared

  18. Thoracic irradiation in Hodgkin's disease: Disease control and long-term complications

    SciTech Connect (OSTI)

    Tarbell, N.J.; Thompson, L.; Mauch, P. (Harvard Medical School, Boston, MA (USA))

    1990-02-01

    A total of 590 patients with Stage IA-IIIB Hodgkin's disease received mantle irradiation at the Joint Center for Radiation Therapy between April 1969 and December 1984 as part of their initial treatment. Recurrence patterns as well as pulmonary, cardiac and thyroid complications were analyzed. Pulmonary recurrence was more frequently seen in patients with large mediastinal adenopathy (LMA); 11% of patients with LMA recurred in the lung in contrast to 3.1% with small or no mediastinal disease, p = 0.003. Hilar involvement, when corrected for size of mediastinal involvement, was not predictive of lung relapse. Patients with LMA also had a high rate of nodal relapse above the diaphragm (40%) following radiation therapy (RT) alone as compared to similarly treated patients with small or no mediastinal adenopathy (6.5%), p less than 0.0001. This risk of nodal recurrence was greatly reduced (4.7%) for LMA patients receiving combined radiation therapy and chemotherapy (CMT), p less than 0.0001. Sixty-seven patients (11%) with hilar or large mediastinal involvement received prophylactic, low dose, whole lung irradiation. No decrease in the frequency of lung recurrence was seen with the use of whole lung irradiation. Radiation pneumonitis was seen in 3% of patients receiving radiation therapy alone. In contrast, the use of whole lung irradiation was associated with a 15% risk of pneumonitis, p = 0.006. The risk of pneumonitis was also significantly increased with the use of chemotherapy (11%), p = 0.0001. Cardiac complications were uncommon with pericarditis being the most common complication (2.2%). Thyroid dysfunction was seen in 25% of patients and appeared to be age-related. These data suggest that the long-term complications of mantle irradiation are uncommon with the use of modern radiotherapeutic techniques.

  19. Econometrics: A Bird's Eye View

    E-Print Network [OSTI]

    Geweke, John; Horowitz, Joel; Pesaran, M Hashem

    cycle of about 7—11 years duration, commonly known as the Juglar cycle. Other economists such as Kitchin, Kuznets and Kondratieff followed Juglar’s lead and discovered the inventory cycle (3—5 years duration), the building cy- cle (15—25 years duration...

  20. Holdover inoculum of Pseudomonas syringae pv. alisalensis from broccoli raab causes disease in subsequent plantings

    E-Print Network [OSTI]

    Cintas, N A; Koike, S T; Bunch, R A; Bull, C T

    2006-01-01

    alisalensis from Broccoli Raab Causes Disease in Subsequentalisalensis from broccoli raab causes disease in subsequentsyringae pv. maculicola causes bacterial spot on many

  1. Rheumatic Heart Disease and Beta-hemolytic Streptococci in Salvador, Brazil: A Study of Slum Health

    E-Print Network [OSTI]

    Tartof, Sara Yee

    2010-01-01

    rheumatic fever and rheumatic heart disease in Africa. S Afrthe chain that links the heart to the throat? Lancet Infectchildren with rheumatic heart disease. J Thorac Cardiovasc

  2. Is coronary heart disease rising in India? A systematic review based on ECG defined coronary heart disease 

    E-Print Network [OSTI]

    Ahmad, N; Bhopal, Raj

    2005-01-01

    The aim of this study was to investigate whether coronary heart disease (CHD) is rising in India and assess the quality of the evidence. Thirty one studies were reviewed. The sample sizes of the studies varied from ...

  3. New insights into the natural history of thrombo-embolic disease provided by imaging and disease quantification 

    E-Print Network [OSTI]

    Murchison, John Tallach

    2013-07-06

    Venous thromboembolism (VTE) is a common disease with a myriad of presentation. It is often difficult to diagnosis with symptoms which are shared with many other disorders. Because of the overlap in symptomatology with ...

  4. Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases

    E-Print Network [OSTI]

    Jackson, Walker S.

    In man, mutations in different regions of the prion protein (PrP) are associated with infectious neurodegenerative diseases that have remarkably different clinical signs and neuropathological lesions. To explore the roots ...

  5. "Falling upon deaf ears" : the case of colloquial architecture

    E-Print Network [OSTI]

    Mejel, Jalal B. (Jalal Bezee)

    1990-01-01

    World War II had instigated a strong national movement in The Middle East. In the Fifties and Sixties this region witnessed the end of colonialism in wide spread revolutions. The predominantly agrarian societies of The ...

  6. Acetone Photophysics at ear Critical to Supercritical Conditions

    E-Print Network [OSTI]

    Seitzman, Jerry M.

    from liquid to gas. Rather, the fuel behaves as a single homogeneous supercritical fluid that exhibits the physical and chemical interactions of the fluid, e.g., jet breakup and eventual mixing of fuel and oxidizer conditions with 266 nm excitation, motivated by an interest in using acetone to study transcritical fuel

  7. Towards Understanding the Symmetry of Human Ears: A Biometric Perspective

    E-Print Network [OSTI]

    Ross, Arun Abraham

    @wvhtf.org. Abaza is also affiliated with Cairo University, Egypt. A. Ross is with the Lane Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, USA. arun.ross@mail.wvu.edu (1

  8. Inner Ear Sensory Epithelia Development and Regulation in Zebrafish 

    E-Print Network [OSTI]

    Sweet, Elly Mae

    2011-10-21

    of interconnected chambers, each with a sensory epithelium comprised of hair cells and support cells for detection of sound and motion. This dissertation focuses on the development and regulation of sensory epithelia in zebrafish and utilizes loss of function..., gain of function and laser ablation techniques. Hair cells and support cells develop from an equivalence group specified by proneural genes encoding bHLH transcription factors. The vertebrate Atoh1 bHLH transciption factor is a potential candidate...

  9. Integrative Analysis of Common Neurodegenerative Diseases Using Gene Association, Interaction Networks and mRNA Expression Data

    E-Print Network [OSTI]

    Koyuturk, Mehmet

    , Inc., Cleveland OH. * Corresponding author Abstract Alzheimer's and Parkinson's diseases (AD and PD Alzheimer's disease (AD) and Parkinson's disease (PD) are caused by progressive degeneration and/or deathIntegrative Analysis of Common Neurodegenerative Diseases Using Gene Association, Interaction

  10. Airborne spread of foot-and-mouth disease - model intercomparison

    SciTech Connect (OSTI)

    Gloster, J; Jones, A; Redington, A; Burgin, L; Sorensen, J H; Turner, R; Dillon, M; Hullinger, P; Simpson, M; Astrup, P; Garner, G; Stewart, P; D'Amours, R; Sellers, R; Paton, D

    2008-09-04

    Foot-and-mouth disease is a highly infectious vesicular disease of cloven-hoofed animals caused by foot-and-mouth disease virus. It spreads by direct contact between animals, by animal products (milk, meat and semen), by mechanical transfer on people or fomites and by the airborne route - with the relative importance of each mechanism depending on the particular outbreak characteristics. Over the years a number of workers have developed or adapted atmospheric dispersion models to assess the risk of foot-and-mouth disease virus spread through the air. Six of these models were compared at a workshop hosted by the Institute for Animal Health/Met Office during 2008. A number of key issues emerged from the workshop and subsequent modelling work: (1) in general all of the models predicted similar directions for 'at risk' livestock with much of the remaining differences strongly related to differences in the meteorological data used; (2) determination of an accurate sequence of events is highly important, especially if the meteorological conditions vary substantially during the virus emission period; and (3) differences in assumptions made about virus release, environmental fate, and subsequent infection can substantially modify the size and location of the downwind risk area. Close relationships have now been established between participants, which in the event of an outbreak of disease could be readily activated to supply advice or modelling support.

  11. Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function*

    E-Print Network [OSTI]

    Li, Lian

    Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function by which loss-of-function mutations in DJ-1 lead to Par- kinson's disease. Parkinson's disease (PD)1 of this devastating disease. Recent evidence indi- cates that at least 10 distinct genetic loci, PARK1­PARK10

  12. Available online at www.sciencedirect.com A cellular perspective on conformational disease: the role of

    E-Print Network [OSTI]

    Morimoto, Richard

    of destabilized proteins. Genetic mutations in conformational disease-associated proteins, as well as exposure in the genetic background may account for some of the cell-type specificity observed in disease, even when neurodegenerative diseases, including Alzheimer's Dis- ease (AD), Parkinson's Disease (PD), Amyotrophic Lat- eral

  13. Clues to How Alpha-Synuclein Damages Neurons in Parkinson's Disease

    E-Print Network [OSTI]

    Sulzer, David

    -synuclein; Parkinson's disease a-SYN AS A CAUSE OF PARKINSON'S DISEASE Multiple genetic mutations can cause ParkinsonClues to How Alpha-Synuclein Damages Neurons in Parkinson's Disease David Sulzer, PhD* Departments vesicles. The pathogenic effects of a-syn leading to Parkin- son's disease (PD) appear to result from

  14. Exploring candidate genes for human brain diseases from a brain-specific gene network

    E-Print Network [OSTI]

    Jiang,Tianzi

    identifying multiple candidate genes for genetic human brain diseases from a brain-specific gene network; Candidate genes Many common human brain diseases, such as schizo- phrenia, Alzheimer's disease, Parkinson's disease, depres- sion, etc., have prominent genetic components [1,2]. Most researchers think that large

  15. Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases*

    E-Print Network [OSTI]

    Li, Lian

    Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases* Received an autosomal recessive, early onset familial form of Parkinson disease (PD). However, little is presently known with sporadic PD and AD. Alzheimer disease (AD)2 and Parkinson disease (PD) are the two most common

  16. South Carolina Pest Management Handbook for Field Crops -2015 TOBACCO DISEASE MANAGEMENT

    E-Print Network [OSTI]

    Stuart, Steven J.

    South Carolina Pest Management Handbook for Field Crops - 2015 293 TOBACCO DISEASE MANAGEMENT Bruce and potentially devastating diseases of tobacco can best be managed through a combination of control methods. It is urged that growers identify disease problems in their fields and follow disease management suggestions

  17. Estimating Seasonal Drivers in Childhood Infectious Diseases with Continuous Time Models 

    E-Print Network [OSTI]

    Abbott, George H.

    2010-07-14

    similar results for a relatively unstudied city in childhood infectious disease research, Bangkok, Thailand....

  18. Remote sensing, global warming, and vector-borne disease

    SciTech Connect (OSTI)

    Wood, B.; Beck, L.; Dister, S.; Lobitz, B.

    1997-12-31

    The relationship between climate change and the pattern of vector-borne disease can be viewed at a variety of spatial and temporal scales. At one extreme are changes such as global warming, which are continental in scale and occur over periods of years, decades, or longer. At the opposite extreme are changes associated with severe weather events, which can occur at local and regional scales over periods of days, weeks, or months. Key ecological factors affecting the distribution of vector-borne diseases include temperature, precipitation, and habitat availability, and their impact on vectors, pathogens, reservoirs, and hosts. Global warming can potentially alter these factors, thereby affecting the spatial and temporal patterns of disease.

  19. Using dimension reduction to improve outbreak predictability of multistrain diseases

    E-Print Network [OSTI]

    Leah B. Shaw; Lora Billings; Ira B. Schwartz

    2006-07-12

    Multistrain diseases have multiple distinct coexisting serotypes (strains). For some diseases, such as dengue fever, the serotypes interact by antibody-dependent enhancement (ADE), in which infection with a single serotype is asymptomatic, but contact with a second serotype leads to higher viral load and greater infectivity. We present and analyze a dynamic compartmental model for multiple serotypes exhibiting ADE. Using center manifold techniques, we show how the dynamics rapidly collapses to a lower dimensional system. Using the constructed reduced model, we can explain previously observed synchrony between certain classes of primary and secondary infectives (Schwartz et al., Phys. Rev. E 72: 066201, 2005). Additionally, we show numerically that the center manifold equations apply even to noisy systems. Both deterministic and stochastic versions of the model enable prediction of asymptomatic individuals that are difficult to track during an epidemic. We also show how this technique may be applicable to other multistrain disease models, such as those with cross-immunity.

  20. Investigation of saliva of patients with periodontal disease using NAA

    SciTech Connect (OSTI)

    Zamboni, C. B.; Metairon, S.; Medeiros, I. M. M. A.

    2013-05-06

    In this study the non-stimulated whole saliva of 26 healthy subjects (mean age 33.9 {+-} 11.0 years, range: 26 to 49 years) and 11 patients with periodontal disease (mean age 41.7 {+-} 11.5 years; range 29 to 55 years) was investigated using Neutron Activation Analysis (NAA) technique. The samples were obtained from donors at Sao Paulo city (Brazil). The analyses were performed in the nuclear reactor IEA-R1 (3.5-4.5MW, pool type) at IPEN/CNEN-SP (Brazil). Considerable changes in Ca and S saliva's level were identified in patients with periodontal disease suggesting they can be used as monitors of periodontal diseases.

  1. Complications of treatment of Hodgkin's disease in children

    SciTech Connect (OSTI)

    Donaldson, S.S.; Kaplan, H.S.

    1982-04-01

    An analysis of complications of therapy requires long-term and frequent followup. Reported here is a review of 179 consecutive children with Hodgkin's disease from Stanford University Medical Center who were seen, treated, and followed over a 20-year period. Complications of treatment are related to the extent of disease and the aggressiveness of therapy. Severe complications from radiotherapy are associated with high-dose, extended-field treatment in preadolescent children. Severe chemotherapy-associated complications include immunosuppression, sterility, and secondary oncogenesis. As cure rates are increasingly optimistic among children with Hodgkin's disease, successful treatment with minimal morbidity remains our greatest challenge. Therapy programs require continual refinement utilizing assessment of short- and long-term side effects of treatment.

  2. Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xia, Jing; Rocke, David M.; Perry, George; Ray, Monika

    2014-01-01

    In late-onset Alzheimer’s disease (AD), multiple brain regions are not affected simultaneously. Comparing the gene expression of the affected regions to identify the differences in the biological processes perturbed can lead to greater insight into AD pathogenesis and early characteristics. We identified differentially expressed (DE) genes from single cell microarray data of four AD affected brain regions: entorhinal cortex (EC), hippocampus (HIP), posterior cingulate cortex (PCC), and middle temporal gyrus (MTG). We organized the DE genes in the four brain regions into region-specific gene coexpression networks. Differential neighborhood analyses in the coexpression networks were performed to identify genes with lowmore »topological overlap (TO) of their direct neighbors. The low TO genes were used to characterize the biological differences between two regions. Our analyses show that increased oxidative stress, along with alterations in lipid metabolism in neurons, may be some of the very early events occurring in AD pathology. Cellular defense mechanisms try to intervene but fail, finally resulting in AD pathology as the disease progresses. Furthermore, disease annotation of the low TO genes in two independent protein interaction networks has resulted in association between cancer, diabetes, renal diseases, and cardiovascular diseases.« less

  3. Compositions and Methods for the Treatment of Pierce's Disease

    DOE Patents [OSTI]

    Gupta, Goutam (Santa Fe, NM)

    2008-10-07

    Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

  4. Neurobiology of Disease Cortical Folding Abnormalities in Autism Revealed by

    E-Print Network [OSTI]

    Van Essen, David

    Neurobiology of Disease Cortical Folding Abnormalities in Autism Revealed by Surface-based morphometry across a range of autism spectrum disorders (7.5­18 years of age). We generated sulcal depth maps autism spectrum disorder subgroups: low-functioning autism, high-functioning autism, and Asperger

  5. Disease Risks Associated with Importation of Nonindigenous Marine Animals

    E-Print Network [OSTI]

    at the Nonindigenous Marine Species Plan ning Mt;eting of the National Research Council, Washington, D.C., 7 May 1991 directed to the third-disease and its implications in introductions. This is entirely logical, since infections that may cause stunting (Kalagayan et aI., 1991). Experimental infections with IHHNV have been

  6. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    ) in five University-based AD centers in the United States and European Union. Four outcomes, assessed every index, and death. Using a standardized portion of the Unified PD Rating Scale (administered every 6 disease (AD). Methods: A total of 533 patients with AD at early stages (mean Folstein Mini-Mental State

  7. Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease

    E-Print Network [OSTI]

    Levenson, Robert W.

    Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease Madeleine instructed and spontaneous emotion regulation in patients with frontotemporal lobar degeneration (FTLD, N 32) unwarned without instructions to down-regulate, (b) warned without instructions to down-regulate, and (c

  8. Azasugar inhibitors as pharmacological chaperones for Krabbe disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hill, Chris H.; Viuff, Agnete H.; Spratley, Samantha J.; Salamone, Stéphane; Christensen, Stig H.; Read, Randy J.; Moriarty, Nigel W.; Jensen, Henrik H.; Deane, Janet E.

    2015-03-23

    Krabbe disease is a devastating neurodegenerative disorder characterized by rapid demyelination of nerve fibers. This disease is caused by defects in the lysosomal enzyme ?-galactocerebrosidase (GALC), which hydrolyzes the terminal galactose from glycosphingolipids. These lipids are essential components of eukaryotic cell membranes: substrates of GALC include galactocerebroside, the primary lipid component of myelin, and psychosine, a cytotoxic metabolite. Mutations of GALC that cause misfolding of the protein may be responsive to pharmacological chaperone therapy (PCT), whereby small molecules are used to stabilize these mutant proteins, thus correcting trafficking defects and increasing residual catabolic activity in cells. Here we describe amore »new approach for the synthesis of galacto-configured azasugars and the characterization of their interaction with GALC using biophysical, biochemical and crystallographic methods. We identify that the global stabilization of GALC conferred by azasugar derivatives, measured by fluorescence-based thermal shift assays, is directly related to their binding affinity, measured by enzyme inhibition. X-ray crystal structures of these molecules bound in the GALC active site reveal which residues participate in stabilizing interactions, show how potency is achieved and illustrate the penalties of aza/iminosugar ring distortion. The structure–activity relationships described here identify the key physical properties required of pharmacological chaperones for Krabbe disease and highlight the potential of azasugars as stabilizing agents for future enzyme replacement therapies. This work lays the foundation for new drug-based treatments of Krabbe disease.« less

  9. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    CME Motor signs predict poor outcomes in Alzheimer disease N. Scarmeas, MD; M. Albert, PhD; J--Objective: To examine whether the presence of motor signs has predictive value for important outcomes in Alzheimer months for a total of 3,149 visit-assessments, average 5.9 per patient), the presence of motor signs

  10. Transmission mode and disease thresholds in host communities Janis Antonovics,

    E-Print Network [OSTI]

    Antonovics, Janis

    1 Transmission mode and disease thresholds in host communities Janis Antonovics, Department of Biology, University of Virginia, VA 22904, USA E-mail: ja8n@virginia.edu Running title Transmission mode transmission have close analogies with thresholds for species persistence when there is competition

  11. Polymorphism in sexual versus non-sexual disease transmission

    E-Print Network [OSTI]

    Antonovics, Janis

    Polymorphism in sexual versus non-sexual disease transmission PETER H. THRALL AND JANIS ANTONOVICS conditions under which a genetic variant with one (e.g. sexual) transmission mode can invade and successfully displace a genetic variant with a different (e.g. non-sexual) transmission mode. Invasion by an STD

  12. GUANYLATE CYCLASE-ACTIVATING PROTEINS AND RETINA DISEASE

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    of the rod cell contains high levels of cGMP (1­10 M) maintaining a number of CNG channels in an open state. Within milliseconds after a light flash, cGMP-gated (CNG) cation channels close and photoreceptor cells hyperpolarize. Open CNG 71 E. Carafoli and M. Brini (eds.), Calcium Signalling and Disease, 71­91. © 2007

  13. Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs

    E-Print Network [OSTI]

    Babu, M. Madan

    31st Jan 2011 Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs M. Madan.....................................................................................................................................2 3.1. IDPs are tightly regulated from transcript synthesis to protein degradation ......................................................................................................................................8 #12;1 Abstract Intrinsically disordered proteins (IDPs) are often enriched in signaling

  14. September/October 2000 New Disease Booklet Web Marketing

    E-Print Network [OSTI]

    Ishida, Yuko

    the Restrictions Strawberry Pollination CSBA Convention Schedule Honey Quality CA Organic Farming New Disease is the APHIS Publication Distribution Center. Strawberry Pollination We don't often look at state or provincial, of Manitoba Agriculture, devised experiments to determine the effect of insect pollination on a strawberry

  15. Bayesian approach to transforming public gene expression repositories into disease

    E-Print Network [OSTI]

    Zhou, Xianghong Jasmine

    expression data and heterogeneous disease annota- tions, allows analyzing both sources of information concepts. This effort requires the effective integration of the two major information sources in the GEO of Southern California, Los Angeles, CA 90089; and c Institute of Genomics and Bioinformatics, National Chung

  16. PUBLICATION 600-080 Fish Health and Disease

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    PUBLICATION 600-080 Fish Health and Disease Striped bass (Morone saxitilis) and hybrid striped bass these fish are commonly raised in high densities under intensive aquaculture situations (e.g., cages, ponds of the viral, bacterial, fungal, and parasitic pathogens, but the fish become increasingly susceptible

  17. Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data

    E-Print Network [OSTI]

    Li, Jing

    Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Shui Huang2 , Jing Li2 to alternation in the functional brain network, i.e., the functional connectivity among different brain regions. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds

  18. Mathematical models and the fight against diseases in Africa

    E-Print Network [OSTI]

    Getz, Wayne M.

    Mathematical models and the fight against diseases in Africa Wayne M.Getz a* ,Eleanor Gouws b theories. While South Africa has many talented scientists trained in quantitative methods, relatively few infrastructural investment is needed to address the health crises in Africa. Prior to the advent of HIV

  19. Diseases of plantation forestry trees in eastern and southern Africa

    E-Print Network [OSTI]

    Diseases of plantation forestry trees in eastern and southern Africa J. Roux a*, G. Meke b , B a Introduction Plantations of non-native trees have been grown in Africa for more than 100 years.1,2 The most especially for construction timber and fuel, while in southern Africa this timber also sustains a thriving

  20. Virus Specificity in Disease Systems: Are Species Redundant?

    E-Print Network [OSTI]

    Flecker, Alex

    Chapter 17 m Virus Specificity in Disease Systems: Are Species Redundant? Alison G. Power about the effects of plant viruses despite their ubiquitous distribution in plants. Several recent studies have stressed the prevalence of viruses in natural plant populations (e.g., Power and Remold 1996

  1. 2006 International Centre for Diarrhoeal Disease Research, Bangladesh

    E-Print Network [OSTI]

    California at Berkeley, University of

    © 2006 International Centre for Diarrhoeal Disease Research, Bangladesh J HEALTH POPUL NUTR 2006, including Inner Mongolia, Thailand, Cambodia, and Bangladesh (2-4). In all these regions, the main source suggests the presence of arsenic in ground- water in India and Bangladesh throughout the region defined

  2. Random Disease on the Square Grid J ozsef Balogh

    E-Print Network [OSTI]

    Balogh, Jozsef

    a disease process. The initial configuration is called contagious or successful if the corresponding) squares in a contagious configuration. The solution of the initial exercise is the following: Fact. [Folklore] G(n) = n. Proof. If we paint the squares of a diagonal black, it will be a contagious

  3. Comparing Online Community Structure of Patients of Chronic Diseases

    E-Print Network [OSTI]

    Maddali, Hanuma Teja; Margolis, Peter

    2015-01-01

    In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.

  4. Prediction and Informative Risk Factor Selection of Bone Diseases

    E-Print Network [OSTI]

    Buffalo, State University of New York

    --Electronic health records (EHRs); risk factor analysis; integrated feature extraction; risk factor selection1 Prediction and Informative Risk Factor Selection of Bone Diseases Hui Li, Xiaoyi Li, Murali and the overwhelming amount of electronic health records (EHRs) shared by healthcare institutions and practitioners, we

  5. A Network-Based Approach to Understanding and Predicting Diseases

    E-Print Network [OSTI]

    Chawla, Nitesh V.

    and emergent behavior over time. Our analysis reveals important insights with implications for modeling increases in cost of health care for the United States. Contributions: The aforementioned issues model to assess disease risk for individuals based on medical history. We evaluate the ability of our

  6. Page 1 of 55 Accepted for publication in1

    E-Print Network [OSTI]

    .g., inhalation of toxic gases from smoke worsen the heart and lung11 diseases, cough and breath, sore eyes, tears

  7. AT A GLANCE....INSECTS AND DISEASE PROBLEMS THAT SHOULD BE CONSIDERED THIS PEST/DISEASE/CULTURE

    E-Print Network [OSTI]

    Goodman, Robert M.

    /DISEASE/CULTURE JULY 8- JULY 15 HARVEST JULY 15- JULY 22 HARVEST SPOTTED WING DROSOPHILA Lannate, Imidan, Malathion effective against aphids and maggot when possible. Monitor with traps, and use materials that are also effective against aphids and maggot when possible. BLUEBERRY MAGGOT See list from previous newsletter

  8. 6/18/13 11:10 AMEye-Tracking Software May Reveal Autism and other Brain Disorders: Scientific American Page 1 of 3http://www.scientificamerican.com/article.cfm?id=eye-tracking-software-may-reveal-autism-and-other-brain-disorders&print=true

    E-Print Network [OSTI]

    Itti, Laurent

    6/18/13 11:10 AMEye-Tracking Software May Reveal Autism and other Brain Disorders: Scientific American Page 1 of 3http://www.scientificamerican.com/article.cfm?id=eye-tracking-software-may-reveal-autism diagnoses of mental and neurological disorders, such as autism, attention-deficit hyperactivity disorder

  9. Unusual thoracic radiographic findings in children treated for Hodgkin's disease

    SciTech Connect (OSTI)

    Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.

    1986-06-01

    Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

  10. Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease

    E-Print Network [OSTI]

    Galvin, James E.; Malcom, Heather; Johnson, David Kevin; Morris, John C.

    2007-05-29

    Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease James E. Galvin, MD, MPH Heather Malcom David Johnson, PhD John C. Morris, MD ABSTRACT Objective: To identify personality traits that distinguish dementia with Lewy... and differentiation in conjunction with other DLB features. METHODS Research participants. Beginning in 1979, over 3,000 individuals have been enrolled in our longitudinal studies of healthy aging and dementia and over 800 of these participants have been studied...

  11. Travel and migration associated infectious diseases morbidity in Europe, 2008

    E-Print Network [OSTI]

    Field, Vanessa; Gautret, Philippe; Schlagenhauf, Patricia; Burchard, Gerd-Dieter; Caumes, Eric; Jensenius, Mogens; Castelli, Francesco; Gkrania-Klotsas, Effrossyni; Weld, Leisa; Lopez-Velez, Rogelio; de Vries, Peter; von Sonnenburg, Frank; Loutan, Louis; Parola, Philippe; Network, the EuroTravNet

    2010-11-17

    to adjust for the large number of statistical tests performed. Ethics approval The GeoSentinel International data-collection protocol used by EuroTravNet was reviewed by the institutional review board officer at the National Center for Infec- tious Diseases... on a return visit to his country of birth Algeria; three cases of toxo- plasmosis, 20 cases of acute Epstein Barr Virus infection, and one case of histoplasmosis. Bacterial infections accounted for most dermatological diagnoses followed by arthropod...

  12. Storage and Diseases of the Sweet Potato in Texas. 

    E-Print Network [OSTI]

    Youngblood, B. (Bonney)

    1919-01-01

    STATION AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS W. B. BIZZELL, President BULLETIN TuO. 250 OCTOBER, 1919 EXPERIMENT STATION AND EXTENSION SERVICE COOPERATING STORAGE AND DISEASES OF THE SWEET POTATO IN TEXAS B. YOUNGBLOOD, DIRECTOR College... cooperation with the United States Department of Agriculture. FOREWORD. Sweet potato storage is a comparatively new industry in Texas. Dur- ing the past few years, hoaeyer, a great deal of interest has been mani- fested in improved methods of storage...

  13. A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

    E-Print Network [OSTI]

    Pagliarini, David J.

    James G. Evans,8 David R. Thorburn,5,6 Steven A. Carr,3,* and Vamsi K. Mootha1,2,3,* 1Center for HumanA Mitochondrial Protein Compendium Elucidates Complex I Disease Biology David J. Pagliarini,1 A. Walford,1,2 Canny Sugiana,5 Avihu Boneh,5,6 William K. Chen,1,2 David E. Hill,7 Marc Vidal,7

  14. Pathogenesis of human papillomavirus-associated mucosal disease

    E-Print Network [OSTI]

    Groves, Ian J.; Coleman, Nicholas

    2014-12-08

    =UTF-8 For Peer Review Pathogenesis of human papillomavirus-associated mucosal disease. Journal: The Journal of Pathology Manuscript ID: Draft Wiley - Manuscript type: Invited Review Date Submitted by the Author: n/a Complete... advantage. Selection of integrated HRHPV occurs relatively early in cervical carcinogenesis and determinants of selection have been difficult to investigate adequately using clinical samples [36]. However, the W12 model of HPV16-associated cervical...

  15. Using Genomics to Study Human Biology and Disease

    SciTech Connect (OSTI)

    Myers, Ricard M.

    2005-04-06

    The Human Genome Project culminated in April 2003 with the finished DNA sequence of all of the human chromosomes. This book of information, particularly in conjunction with the genome sequences of many other organisms, has already begun to revolutionize the way that biomedical scientists study our species. The identification of essentially all of our genes has provided a template upon which researchers can discover basic processes that govern cells, organs, and the whole organism, and to understand the fundamental causes of the diseases that occur when something goes wrong with a gene or a set of genes. The Genome Project has already made it possible to identify the genes that are defective in more than 1,000 rare inherited diseases, and these discoveries have helped to understand the mechanisms of the more common forms of these disorders. This understanding of primary defects in diseases - which is translated as mutations in genes that encode proteins that serve specific functions - is transforming the way that biotechnology and pharmaceutical companies identify drug targets, and a few notable cases have already had a striking impact on specific diseases. In addition, it has become clear that the differential response to drugs in human populations is heavily influenced by genes, and a whole field called pharmacogenetics has begun to identify these genetic factors. Such knowledge will allow physicians to prescribe drugs targeted to each individual, with the potential to increase efficacy and decrease side-effects. Determining the DNA sequence of the human genome and identifying the genes has been an exciting endeavor, but we are only just beginning to understand the treasures present in all of our DNA. My presentation will briefly describe the road we took to get the sequence, as well as the tools that we are developing to unlock its secrets.

  16. Selection of a multiple disease resistant runner-type peanut 

    E-Print Network [OSTI]

    Baring, Michael Robert

    2007-09-17

    SELECTION OF A MULTIPLE DISEASE RESISTANT RUNNER-TYPE PEANUT A Thesis by MICHAEL ROBERT BARING Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE... of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, William Rooney Committee Members, Charles Simpson James Starr Robert Lemon Head of Department, C.W. Smith May 2006 Major Subject: Plant...

  17. Disease-induced resource constraints can trigger explosive epidemics

    E-Print Network [OSTI]

    Böttcher, Lucas; Araújo, Nuno A M; Herrmann, Hans J; Helbing, Dirk

    2015-01-01

    Advances in mathematical epidemiology have led to a better understanding of the risks posed by epidemic spreading and informed strategies to contain disease spread. However, a challenge that has been overlooked is that, as a disease becomes more prevalent, it can limit the availability of the capital needed to effectively treat those who have fallen ill. Here we use a simple mathematical model to gain insight into the dynamics of an epidemic when the recovery of sick individuals depends on the availability of healing resources that are generated by the healthy population. We find that epidemics spiral out of control into "explosive" spread if the cost of recovery is above a critical cost. This can occur even when the disease would die out without the resource constraint. The onset of explosive epidemics is very sudden, exhibiting a discontinuous transition under very general assumptions. We find analytical expressions for the critical cost and the size of the explosive jump in infection levels in terms of the...

  18. Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk

    E-Print Network [OSTI]

    Koenig, Gerald

    2015-01-01

    Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT’s predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a ...

  19. Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

    E-Print Network [OSTI]

    Young, Carissa L.

    Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across ...

  20. Correlation of Klebsiella pneumoniae Comparative Genetic Analyses with Virulence Profiles in a Murine Respiratory Disease Model

    E-Print Network [OSTI]

    Fodah, Ramy A.

    Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied ...

  1. Precision medicine in chronic disease management: The multiple sclerosis BioScreen

    E-Print Network [OSTI]

    2014-01-01

    Disease Management: The Multiple Sclerosis BioScreen Pierre-unpredictable disease like multiple sclerosis? Eur J NeurolHL. The challenge of multiple sclerosis: how do we cure a

  2. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk

    E-Print Network [OSTI]

    Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus). Subsequently, the disease was diagnosed in black-tailed deer, Rocky Mountain elk (Williams & Young, 1982, 1992

  3. Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg. 

    E-Print Network [OSTI]

    Stephens LA; Malpass KH; Anderton SM

    2009-01-01

    The potential use of CD4(+)Foxp3(+) Treg as a cellular therapy for autoimmune disease is of great interest. For clinical translation, the key objective is to reverse established disease. Here we demonstrate that myelin ...

  4. Inflammation and haemostasis in the development and progression of peripheral atherosclerotic disease 

    E-Print Network [OSTI]

    Tzoulaki, Ioanna

    2007-01-01

    Peripheral arterial disease (PAD) defines atherosclerotic disease of the arteries to the legs. PAD begins early in life and remains asymptomatic over long periods. The ankle brachial index (ABI) is an important diagnostic ...

  5. Morphological, cellular and proteomic features of canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Han, Richard I-Ming

    2009-01-01

    Myxomatous mitral valve degeneration (MMVD) is the single most common cardiac disease of the dog, and is analogous to Mitral Valve Prolapse in humans. Very little is known about the aetiopathogenesis of this disease or ...

  6. Economic Consequences Associated with Johne’s Disease in Cow-Calf Operations 

    E-Print Network [OSTI]

    Bhattarai, Bikash

    2013-08-05

    Johne’s disease (JD) in cattle is a disease of economic importance caused by Mycobacterium avium subspecies paratuberculosis (MAP). Studies were conducted to estimate the losses due to lower weaning weight of beef calves ...

  7. HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF ENERGY CONSERVATION IN BUILDINGS

    E-Print Network [OSTI]

    Budnitz, R.J.

    2011-01-01

    Snihs, "The Significance of Radon and Its Progeny as NaturalDivision Human Disease from Radon Exposures: The I P ImpactVent 78-5 HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF

  8. v-abl causes hematopoietic disease distinct from that caused by bcr-abl.

    E-Print Network [OSTI]

    Scott, M L; Van Etten, R A; Daley, G Q; Baltimore, D

    1991-01-01

    Medical Sciences v-abl causes hematopoietic disease distinctcells. bcr-abl also causes a CML-like syndrome in mice whosevirus-containing sys- tem, causes disease similar to, but

  9. Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration.

    E-Print Network [OSTI]

    2007-01-01

    in Alzheimer’s disease causes neuronal death. FASEB J. 2001;Manuscript Figure 1. UbB + 1 causes neuritic beading andfound in Alzheimer’s disease causes neuritic beading of

  10. Structural Findings in the Basal Ganglia in Genetically Determined and Idiopathic Parkinson's Disease

    E-Print Network [OSTI]

    Gaser, Christian

    Structural Findings in the Basal Ganglia in Genetically Determined and Idiopathic Parkinson likely have an increased risk to develop Parkinson's disease (PD). We hypothesized BG morphological Key words: basal ganglia; magnetic resonance imaging; Parkinson's disease; Parkin mutation carriers

  11. Immunization with a Borrelia burgdorferi BB0172-Derived Peptide Protects Mice against Lyme Disease 

    E-Print Network [OSTI]

    Small, Christina M.; Ajithdoss, Dharani K.; Hoffmann, Aline Rodrigues; Mwangi, Waithaka; Esteve-Gassent, Maria D.

    2014-02-05

    Lyme disease is the most prevalent arthropod borne disease in the US and it is caused by the bacterial spirochete Borrelia burgdorferi (Bb), which is acquired through the bite of an infected Ixodes tick. Vaccine development efforts focused...

  12. The development of new tools for field and laboratory diagnosis of Pierces Disease 

    E-Print Network [OSTI]

    Bryan, Kelly Asbill

    2009-05-15

    Pierce’s Disease (PD), caused by Xylella fastidiosa, is a devastating bacterial disease of grapevines. One of the few control options is roguing. Roguing depends on precise diagnosis of PD in vines. These experiments were conducted to improve...

  13. High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women 

    E-Print Network [OSTI]

    Ghahramany, Ghazal

    2012-07-16

    About half of all deaths in developed countries are caused by cardiovascular disease. It is well known that cardiovascular disease (CVD) risk can be influenced by diet, but optimal dietary content of fatty acids continues ...

  14. Di#erential equation models for Aujeszky's Disease Virus (ADV) in Irish pig herds

    E-Print Network [OSTI]

    , Dublin City University, Dublin 9, Ireland Abstract Aujeszky's Disease virus, (ADV) is a contagious viral Aladar Aujeszky, when he distinguished psuedorabies from rabies [23]. Aujeszky's Disease is a contagious

  15. Micro-Simulations of Infectious Disease using Official Register Data The Case of Smallpox

    E-Print Network [OSTI]

    Boman, Magnus

    , for example. #12;Introduction Should an infection of a contagious disease occur, the potential threat must be seen as an example of a predominantly airborne, fairly contagious vaccine-preventable disease where

  16. Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

    E-Print Network [OSTI]

    Thompson, Paul

    Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla and Alzheimer's disease based on high resolution MRI at 3 Tesla. T1-weighted images were acquired from 19

  17. Pharmacological Chaperone Design for Reducing Risk Factor of Parkinson’s Disease from Traditional Chinese Medicine

    E-Print Network [OSTI]

    Huang, Hung-Jin

    Dysfunction of ?-glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson’s disease occurrence. Pharmacological chaperone design has been used to ...

  18. CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

    E-Print Network [OSTI]

    Rezai-Zadeh, Kavon; Gate, David; Town, Terrence

    2009-01-01

    encephalitis . multiple sclerosis . experimental autoimmunedisease (AD), multiple sclerosis (MS), and Parkinson'sdemyelinating disease multiple sclerosis) and may also be

  19. Association Analysis of the Extended MHC Region in Celiac Disease Implicates Multiple Independent Susceptibility Loci

    E-Print Network [OSTI]

    2012-01-01

    Symposium on Coeliac Disease. Tampere, Finland: Institute ofTechnology, University of Tampere. pp 265–274. 25. Hall RP,

  20. "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2

    E-Print Network [OSTI]

    Watson, Craig A.

    VM85 "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2 1. This document is VM85 fish is generically referred to as "red sore disease." This problem usually occurs in the spring on their fish. Typically, "red sore disease" is caused by two organisms, Aeromonas hydrophila , a bacterium

  1. Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases*

    E-Print Network [OSTI]

    Li, Lian

    and Parkinson Diseases* Received for publication, December 20, 2004, and in revised form, January 18, 2005 oxidative stress has been strongly impli- cated in the pathogenesis of Alzheimer disease (AD) and Parkinson(s) that could potentially be tar- geted by similar therapeutic strategies. Alzheimer disease (AD),1 Parkinson

  2. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit

    E-Print Network [OSTI]

    Guo, Ming

    of Parkinson's disease. pink1 acts upstream of parkin in a common genetic pathway to regulate mitochondrialThe Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion represent a novel therapeutic strategy for Parkinson's disease. mitofusin drp1 opa1 parkin-pink1 Parkinson

  3. 8 THE AMERICAN SOCIETY FOR CELL BIOLOGY PRESS BOOK 2004 arkinson's disease (PD) was named

    E-Print Network [OSTI]

    Feng, Jian

    as a progressive neurodegenerative disease. Parkinson's is caused by the selective death of neurons that produce-radical-damaged tubulin. In this fight, mutated parkin apparently arrives unarmed. Parkinson's Disease: Shootout8 THE AMERICAN SOCIETY FOR CELL BIOLOGY PRESS BOOK 2004 P arkinson's disease (PD) was named

  4. Neurodegeneration and Neuroprotection in Parkinson Disease Stanley Fahn and David Sulzer

    E-Print Network [OSTI]

    Sulzer, David

    Neurodegeneration and Neuroprotection in Parkinson Disease Stanley Fahn and David Sulzer Department Parkinson disease (PD) result primarily from the loss of the neuromelanin (NM)-containing dopamine (DA, with at least one of them being tremor-at-rest or brady- kinesia. Parkinson disease (PD) is the major cause

  5. Parkinson's disease (PD) is characterized by the rela-tively selective degeneration of dopaminergic neurons in

    E-Print Network [OSTI]

    Feng, Jian

    Parkinson's disease (PD) is characterized by the rela- tively selective degeneration into a stiff, hollow tube. Each Microtubule: A Common Target for Parkin and Parkinson's Disease Toxins JIAN performed on twins (Tanner and others 1999), reveal strong environmental connections to the disease

  6. Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the

    E-Print Network [OSTI]

    Shorter, James

    Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the loss motor and cognitive problems. Although the disease was first described in 1817 (Parkinson, 2002), few treatments exist today. These treatments do not target the cause of the disease and instead aim to increase

  7. Neurobiology of Disease Functional Analysis of VPS41-Mediated Neuroprotection in

    E-Print Network [OSTI]

    Caldwell, Guy

    elegans and Mammalian Models of Parkinson's Disease Adam J. Harrington,1 Talene A. Yacoubian,2 Sunny R Disruptionofthelysosomalsystemhasemergedasakeycellularpathwayintheneurotoxicityof -synuclein( -syn)andtheprogression of Parkinson's disease (PD). A large-scale RNA interference for the treatment of synucleinopathies like PD. Introduction Parkinson's disease (PD) is the second most common

  8. Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3

    E-Print Network [OSTI]

    Li, Lian

    Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase autosomal recessive forms of Parkinson disease (PD), but how these mutations trigger neurodegeneration pathway in the pathogenesis of PD. INTRODUCTION Parkinson disease (PD) is the most common neurodegenera

  9. Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis

    E-Print Network [OSTI]

    Abecasis, Goncalo

    ARTICLE Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis1,24,* Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically and enlarge the map of shared genetic risk loci. Introduction Psoriasis (PS [MIM 177900]) and Crohn disease

  10. Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease

    E-Print Network [OSTI]

    Carbonell, Jaime

    Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease Selen Uguroglu and Jaime Pittsburgh, PA 15212 Abstract We investigate machine learning methods for diagnos- tic screening of heart disease. Coronary heart disease is the leading cause of death in the US, causing more deaths than all

  11. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort

    E-Print Network [OSTI]

    van Geen, Alexander

    13 million residents in the United States.1 Although the International Agency for Research on Cancer Death from cardiovascular disease. Results 198 people died from diseases of circulatory system, accounting for 43% of total mortality in the population. The mortality rate for cardiovascular disease

  12. Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP)

    E-Print Network [OSTI]

    Charette, André

    Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP) Neurodegenerative diseases represent one of the most difficult classes of diseases for which to develop drugs, yet, offering a huge opportunity to target some of these pathways with repurposed drugs approved

  13. The Diet-Heart Hypothesis: a critical appraisal of the relationship between diet and coronary artery disease

    E-Print Network [OSTI]

    Jurewitz, Daniel L

    2007-01-01

    for Prevention of Coronary Heart Disease. JAMA. 2002;288:M. Fish consumption and coronary heart disease mortality: aacid and risk of ischemic heart disease among women. Am J

  14. Detection of bone disease in dogs by radioisotope scanning 

    E-Print Network [OSTI]

    Morris, Earl Louis

    1971-01-01

    in dogs for the diagnosis and progression of bone disease was studied. Twc isotopes of strontium, Sr and 85 87m Sr, were studied. The Sr was purchased 85 commercially and the Sr was produced at the 87m Texas A8cM University Nuclear Science Center... by the irradiation oi' Sr(N05)2. Criteria for bone scanning in dogs using Sr 85 and Sr were determined. Pour normal young dogs 87m were injected with Sr and four with Sr. Doses 85 87m of 100 p&i of Sr and 1 mCi of Sr were found . to 85 87m produoe satisfactory...

  15. Programming of cardiovascular disease across the life-course

    E-Print Network [OSTI]

    Blackmore, Heather L.; Ozanne, Susan E.

    2014-12-12

    ]. This increase in lifespan brings about a rise in age-associated conditions such as type 2 diabetes, cancer and cardiovascular disease (CVD). As CVD has a long pre-clinical phase resulting in diagnosis in old age, the identification of biomarkers that precede... F, Carter F, Walsh SW, Kenny DA, Smith GW, Ireland JL, et al. Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring. Biol Reprod. 2013;88:92. [33] Gilbert JS, Lang AL, Grant AR, Nijland MJ. Maternal nutrient...

  16. The Emergence of ActualThe Emergence of Actual Human Disease as a Model forHuman Disease as a Model for

    E-Print Network [OSTI]

    Boguski, Mark S.

    + Chromosomome +e + ""icsics"" == GenomicsGenomics 1990 Human Genome Project launched1990 Human Genome Project launched 1998 Human Genome Project1998 Human Genome Project acceleratedaccelerated 20002000 ""DraftThe Emergence of ActualThe Emergence of Actual Human Disease as a Model forHuman Disease as a Model

  17. Osteogenic Sarcoma of the Maxilla: Neutron Therapy for Unresectable Disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Smoron, Geoffrey L.; Lennox, Arlene J.; Mcgee, James L.

    1999-01-01

    Purpose. To present a case study involving the use of fast neutron therapy to treat an extensive unresectable osteogenic sarcoma arising from the left maxilla. Patient. A 14-year-old male presented with a massive tumor producing severe distortion of his facial structures. He had already received six courses of chemotherapy, which had reduced his pain, but had not measurably reduced the tumor. Methods. The patient was treated with 66 MeV fast neutrons to a dose of 20.4 Gy in 13 fractions over 35 days. Results. CT assessments indicate gradually increasing calcification and noticeable reductionmore »of soft-tissue disease in the frontal sinus, orbit and maxillary antrum.There has been some recontouring of the facial structures.The boy conducts an active life, has no pain, and feels well. He was 17 years old at the last follow-up. Discussion. Fast neutrons have a greater biological effectiveness than conventional photon beams. Their use has been associated with improved chance for local control of unresectable disease.This case illustrates their effectiveness in controlling an unusual and aggressive osteogenic sarcoma of the facial bone and sinuses. « less

  18. Enhanced vector borne disease surveillance of California Culex mosquito populations reveals spatial and species-specific barriers of infection.

    SciTech Connect (OSTI)

    VanderNoot, Victoria A.; Curtis, Deanna Joy; Koh, Chung-Yan; Brodsky, Benjamin H; Lane, Todd

    2014-08-01

    Monitor i ng in f ectio n s in v ect o rs su c h as m osquit o es, s a nd fl i es, tsetse fl i es, a nd ticks to i denti f y hu m a n path o gens m a y s e r v e as a n ear l y w arn i ng det e ction system t o dir e ct loc a l g o v er n ment dise a se pr e v en t i v e m easu r e s . One major hurdle i n de t ection is the abi l i t y to scre e n l arge n u mbers of v e c t ors for h uman patho g ens w i thout t h e u s e of ge n o t y pe - s p ecific m o lecu l ar tec h nique s . N e x t genera t ion s equ e nc i ng (NG S ) pr o v i des a n unbi a sed p latfo r m capab l e of identi f y i ng k n o w n a n d unk n o w n p ath o ge n s circula t ing w i thin a v e ctor p opul a tion, but utili z ing t h is te c h nolo g y i s tim e - con s u ming a n d cos t l y for v ecto r -b o rne disease su r v e illan c e pr o gra m s. T o addr e s s this w e d e v e lop e d cos t -eff e ct i v e Ilumina(r) R NA- S eq l i bra r y p r epara t ion m e thodol o gies i n con j u n ction w i t h an automa t ed c ompu t at i onal a n a l y sis pipel i n e to ch a racter i ze t h e microbial popula t ions c ircula t i n g in Cu l e x m o squit o e s (Cul e x qui n quef a s c iatu s , C ul e x quinq u efasc i atus / pip i ens co m pl e x h y bri d s, and C u l e x ta r salis ) t hroug h out Californ i a. W e assembled 2 0 n o vel a n d w e l l -do c ume n ted a r b o v i ruses repres e nting mem b e rs of B u n y a v ir i da e , F l a v i virid a e, If a virida e , Meson i v i rida e , Nid o v iri d ae, O rtho m y x o virid a e, Pa r v o v iri d ae, Re o virid a e, R h a b d o v i rid a e, T y m o v iri d ae, a s w ell as s e v e r al u n assi g n e d v irus e s . In addit i o n, w e m app e d mRNA s pecies to d i vergent s peci e s of t r y panos o ma a nd pl a s modium eu k a r yotic parasit e s and cha r a c terized t he p r oka r yot i c microb i al c o mposit i on to i d enti f y bacteri a l tran s c r ipts der i v ed from wolba c hia, clo s tridi u m, m y c oplas m a, fusoba c terium and c am p y l o bacter bac t er i al spec i e s . W e utilized the s e mic r obial transcri p tomes pre s e nt in g e ogra p hical l y defined Cul e x po p ul a tions to defi n e spatial and m osqui t o specie s -spec i fic ba r r iers of i n fecti o n. T he v i r ome and microbi o me c o mpos i tion id e ntified in e ach mosqui t o p o ol pr o v i ded suf f icient resolut i on to dete r m i ne both the mosq u ito species and the g e o graphic regi o n in Californ i a w h e re t h e mosqui t o po o l orig i n ated. T his d a ta pr o v i des ins i ght in t o the compl e x i t y of microb i al spec i es cir c ulati n g in med i cal l y i mport a nt Culex mosqui t oes a nd t h eir potent i al im p act o n t he tran s missi o n of v ector-b o rne human / veter i na r y p a t hogens in C a liforn i a.

  19. Bead-based microfluidic immunoassay for diagnosis of Johne's disease

    SciTech Connect (OSTI)

    Wadhwa, Ashutosh [University of Tennessee, Center for Wildlife Health, Department of Forestry; Foote, Robert [ORNL; Shaw, Robert W [ORNL; Eda, Shigetoshi [ORNL

    2012-01-01

    Microfluidics technology offers a platform for development of point-of-care diagnostic devices for various infectious diseases. In this study, we examined whether serodiagnosis of Johne s disease (JD) can be conducted in a bead-based microfluidic assay system. Magnetic micro-beads were coated with antigens of the causative agent of JD, Mycobacterium avium subsp. paratuberculosis. The antigen-coated beads were incubated with serum samples of JD-positive or negative serum samples and then with a fluorescently-labeled secondary antibody (SAB). To confirm binding of serum antibodies to the antigen, the beads were subjected to flow cytometric analysis. Different conditions (dilutions of serum and SAB, types of SAB, and types of magnetic beads) were optimized for a great degree of differentiation between the JD-negative and JD-positive samples. Using the optimized conditions, we tested a well-classified set of 155 serum samples from JD negative and JD-positive cattle by using the bead-based flow cytometric assay. Of 105 JD-positive samples, 63 samples (60%) showed higher antibody binding levels than a cut-off value determined by using antibody binding levels of JD-negative samples. In contrast, only 43-49 JD-positive samples showed higher antibody binding levels than the cut-off value when the samples were tested by commercially-available immunoassays. Microfluidic assays were performed by magnetically immobilizing a number of beads within a microchannel of a glass microchip and detecting antibody on the collected beads by laser-induced fluorescence. Antigen-coated magnetic beads treated with bovine serum sample and fluorescently-labeled SAB were loaded into a microchannel to measure the fluorescence (reflecting level of antibody binding) on the beads in the microfluidic system. When the results of five bovine serum samples obtained with the system were compared to those obtained with the flow cytometer, a high level of correlation (linear regression, r2 = 0.994) was observed. In a further experiment, we magnetically immobilized antigen-coated beads in a microchannel, reacted the beads with serum and SAB in the channel, and detected antibody binding to the beads in the microfluidic system. A strong antibody binding in JD-positive serum was detected, whereas there was only negligible binding in negative control experiments. Our data suggest that the bead-based microfluidic system may form a basis for development of an on-site serodiagnosis of JD. Key Words: Mycobacterium avium ssp. paratuberculosis, Johne s disease, microfluidics, lab-on-a-chip.

  20. Development and Deployment of a Compact Eye-Safe Scanning Differential absorption Lidar (DIAL) for Spatial Mapping of Carbon Dioxide for Monitoring/Verification/Accounting at Geologic Sequestration Sites

    SciTech Connect (OSTI)

    Repasky, Kevin

    2014-03-31

    A scanning differential absorption lidar (DIAL) instrument for monitoring carbon dioxide has been developed. The laser transmitter uses two tunable discrete mode laser diodes (DMLD) operating in the continuous wave (cw) mode with one locked to the online absorption wavelength and the other operating at the offline wavelength. Two in-line fiber optic switches are used to switch between online and offline operation. After the fiber optic switch, an acousto- optic modulator (AOM) is used to generate a pulse train used to injection seed an erbium doped fiber amplifier (EDFA) to produce eye-safe laser pulses with maximum pulse energies of 66 {micro}J, a pulse repetition frequency of 15 kHz, and an operating wavelength of 1.571 {micro}m. The DIAL receiver uses a 28 cm diameter Schmidt-Cassegrain telescope to collect that backscattered light, which is then monitored using a photo-multiplier tube (PMT) module operating in the photon counting mode. The DIAL instrument has been operated from a laboratory environment on the campus of Montana State University, at the Zero Emission Research Technology (ZERT) field site located in the agricultural research area on the western end of the Montana State University campus, and at the Big Sky Carbon Sequestration Partnership site located in north-central Montana. DIAL data has been collected and profiles have been validated using a co-located Licor LI-820 Gas Analyzer point sensor.

  1. Facial reconstruction anatomical art or artistic Caroline Wilkinson

    E-Print Network [OSTI]

    Frey, Pascal

    for the morphology of the ears and mouth, and with the skin for an ageing adult. The greatest accuracy is possible of the muscles of mastication, and the outer canthal angle of the eye may appear upturned due to a combination

  2. Building Student Understanding and Interest in Science through Embodied Experiences with LEGO Robotics

    E-Print Network [OSTI]

    Building Student Understanding and Interest in Science through Embodied Experiences with LEGO embodied experiences with LEGO robotics can build elementary school students' understanding of and interest as the robot's hands, ears, eyes, etc. Students can build different types of "robots" and create commands

  3. Importance of Measurement: The Impact of Power Quality in Energy Efficiency 

    E-Print Network [OSTI]

    Qazi, T.; Roy, S.

    2010-01-01

    eyes and ears. The principle is you cannot control what you cannot measure. Looking closer at the power side, the inefficiencies caused by power quality issues such as power factor and harmonics have often been easily overlooked due to the traditional...

  4. Classification of interstitial lung disease patterns with topological texture features

    E-Print Network [OSTI]

    Huber, Markus B; Leinsinger, Gerda; Ray, Lawrence A; Wismüller, Axel; 10.1117/12.844318

    2010-01-01

    Topological texture features were compared in their ability to classify morphological patterns known as 'honeycombing' that are considered indicative for the presence of fibrotic interstitial lung diseases in high-resolution computed tomography (HRCT) images. For 14 patients with known occurrence of honey-combing, a stack of 70 axial, lung kernel reconstructed images were acquired from HRCT chest exams. A set of 241 regions of interest of both healthy and pathological (89) lung tissue were identified by an experienced radiologist. Texture features were extracted using six properties calculated from gray-level co-occurrence matrices (GLCM), Minkowski Dimensions (MDs), and three Minkowski Functionals (MFs, e.g. MF.euler). A k-nearest-neighbor (k-NN) classifier and a Multilayer Radial Basis Functions Network (RBFN) were optimized in a 10-fold cross-validation for each texture vector, and the classification accuracy was calculated on independent test sets as a quantitative measure of automated tissue characteriza...

  5. Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease

    SciTech Connect (OSTI)

    Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

    1988-07-01

    The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

  6. Why my disease is important: metrics of disease occurrence used in the introductory sections of papers in three leading general medical journals in 1993 and 2003

    E-Print Network [OSTI]

    Gouda, Hebe N.; Powles, John W.

    2011-05-23

    stream_source_info 1478-7954-9-14.pdf.txt stream_content_type text/plain stream_size 20996 Content-Encoding UTF-8 stream_name 1478-7954-9-14.pdf.txt Content-Type text/plain; charset=UTF-8 RESEARCH Open Access Why my disease... is important: metrics of disease occurrence used in the introductory sections of papers in three leading general medical journals in 1993 and 2003 Hebe N Gouda* and John W Powles Abstract Background: We assessed the metrics used in claims about disease...

  7. Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification

    E-Print Network [OSTI]

    Tong, Lily Victoria

    2008-01-01

    Human societies face diverse health challenges including a rapidly aging population, rising incidence of metabolic disease, and increasing antibiotic resistance. These problems involve complex interactions between genes ...

  8. Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  9. Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  10. Integrated rotation systems for soilborne disease, weed and fertility management in strawberry/vegetable production

    E-Print Network [OSTI]

    2014-01-01

    dahliae infection rate of strawberry plants at the organicsoilborne diseases in strawberry using vegetable rotations.Fertility Management in Strawberry/Vegetable Production M.

  11. Possible common e,ological agent for strawberry disease and red mark syndrome in

    E-Print Network [OSTI]

    Kane, Andrew S.

    1 Possible common e,ological agent for strawberry disease and red mark Schering-Plough Animal Health, UK Possible common e,ological agent for strawberry

  12. Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

    E-Print Network [OSTI]

    2014-01-01

    Integrative Genomics Reveals Novel Molecular Pathways and7 | e1004502 Integrative Genomics of Coronary Artery Disease2012) Use of functional genomics to identify candidate genes

  13. On the multiscale modeling of heart valve biomechanics in health and disease

    E-Print Network [OSTI]

    Weinberg, Eli J.; Shahmirzadi, Danial; Mofrad, Mohammad Reza

    2010-01-01

    carried out on simulating biomechanics of mechan- ical andmodeling of heart valve biomechanics in health and diseasemodeling of heart valve biomechanics in health and disease

  14. Testing new dairy cattle for disease can boost herd health, cut costs

    E-Print Network [OSTI]

    Moore, Dale A; Adaska, J M; Higginbotham, G E; Castillo, Alejandro R Dr.; Collar, Carol; Sischo, William M

    2009-01-01

    Article t Testing new dairy cattle for disease can boosttest or exam- ine incoming cattle, although these importantin purchased groups of dairy cattle, in order to pro- vide

  15. Psoriasis in a 3-month-old infant with Kawasaki disease

    E-Print Network [OSTI]

    Liao, Yi-Chen; Lee, Julia Yu-Yun

    2009-01-01

    pincer nail deformity. Psoriasis or pityriasis lichenoides2 Figure 1. KD-associated psoriasis in the acute phase of KDFinkelstein Y. Guttate psoriasis following Kawasaki disease.

  16. Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2013-01-01

    lower leg of a patient with psoriasis vulgaris. Acta Dermleg of a patient with psoriasis vulgaris.Acta Derm Venereol.Behcet's disease, psoriasis and hidradenitis suppurativa.

  17. A model for the coupled disease dynamics of HIV and HSV-2 with ...

    E-Print Network [OSTI]

    Christina Alvey

    2015-05-19

    May 4, 2015 ... We conclude that homosexual transmission drastically changes the disease prevalences; hence, it is important to account for this interaction as ...

  18. The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Groza, Tudor; Köhler, Sebastian; Moldenhauer, Dawid; Vasilevsky, Nicole; Baynam, Gareth; Zemojtel, Tomasz; Schriml, Lynn Marie; Kibbe, Warren Alden; Schofield, Paul N.; Beck, Tim; et al

    2015-06-25

    The Human Phenotype Ontology (HPO) is widely used in the rare disease community for differential diagnostics, phenotype-driven analysis of next-generation sequence-variation data, and translational research, but a comparable resource has not been available for common disease. Here, we have developed a concept-recognition procedure that analyzes the frequencies of HPO disease annotations as identified in over five million PubMed abstracts by employing an iterative procedure to optimize precision and recall of the identified terms. We derived disease models for 3,145 common human diseases comprising a total of 132,006 HPO annotations. The HPO now comprises over 250,000 phenotypic annotations for over 10,000more »rare and common diseases and can be used for examining the phenotypic overlap among common diseases that share risk alleles, as well as between Mendelian diseases and common diseases linked by genomic location. The annotations, as well as the HPO itself, are freely available.« less

  19. Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2013-01-01

    any joint disease of the vertebral column. As such, it is ainvolvement of the vertebral column from any type of joint

  20. The role of phenoloxidase suppression in QX disease outbreaks among Sydney rock oysters

    E-Print Network [OSTI]

    Raftos, David

    disease. Oysters from the same brood stock were harvested from QX prone and QX free growing areas over negative correlation between phenoloxidase activity and the intensity of parasitic infection ( p = 0 prevented effective management of QX disease in endemic areas. Current management regimes rely only