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Sample records for developmental assignment evaluation

  1. SESCDP Supervisor's Evaluation of Candidate's Performance During

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Developmental Assignment | Department of Energy SESCDP Supervisor's Evaluation of Candidate's Performance During Developmental Assignment SESCDP Supervisor's Evaluation of Candidate's Performance During Developmental Assignment Form used by SES Supervisor to evaluate a SES candidate's performance in terms of meeting assignment objectives, an overall rating of the candidate's performance, evaluation of executive core qualifications SESCDP Supervisor's Evaluation of Candidate's Performance

  2. Laboratory evaluation of dynamic traffic assignment systems: Requirements, framework, and system design

    SciTech Connect (OSTI)

    Miaou, S.-P.; Pillai, R.S.; Summers, M.S.; Rathi, A.K.; Lieu, H.C.

    1997-01-01

    The success of Advanced Traveler Information 5ystems (ATIS) and Advanced Traffic Management Systems (ATMS) depends on the availability and dissemination of timely and accurate estimates of current and emerging traffic network conditions. Real-time Dynamic Traffic Assignment (DTA) systems are being developed to provide the required timely information. The DTA systems will provide faithful and coherent real-time, pre-trip, and en-route guidance/information which includes routing, mode, and departure time suggestions for use by travelers, ATIS, and ATMS. To ensure the credibility and deployment potential of such DTA systems, an evaluation system supporting all phases of DTA system development has been designed and presented in this paper. This evaluation system is called the DTA System Laboratory (DSL). A major component of the DSL is a ground- truth simulator, the DTA Evaluation System (DES). The DES is envisioned to be a virtual representation of a transportation system in which ATMS and ATIS technologies are deployed. It simulates the driving and decision-making behavior of travelers in response to ATIS and ATMS guidance, information, and control. This paper presents the major evaluation requirements for a DTA Systems, a modular modeling framework for the DES, and a distributed DES design. The modeling framework for the DES is modular, meets the requirements, can be assembled using both legacy and independently developed modules, and can be implemented as a either a single process or a distributed system. The distributed design is extendible, provides for the optimization of distributed performance, and object-oriented design within each distributed component. A status report on the development of the DES and other research applications is also provided.

  3. Parameter assignments for spectral gamma-ray borehole calibration models. National Uranium Resource Evaluation

    SciTech Connect (OSTI)

    Heistand, B.E.; Novak, E.F.

    1984-04-01

    This report documents the work performed to determine the newly assigned concentrations for the spectral gamma-ray borehole calibration models. Thirty-two models, maintained by the US Department of Energy, are included in this study, and are grouped into eight sets of four models each. The eight sets are located at sites across the United States, and are used to calibrate logging instruments. The assignments are based on in-situ logging data to ensure self-consistency in the assigned concentrations, and on laboratory assays of concrete samples from each model to provide traceability to the New Brunswick Laboratory (NBL) standards. 13 references, 7 figures, 17 tables.

  4. Intergovernmental Personnel Act Assignments

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-08-24

    This Manual implements provisions of the Intergovernmental Personnel Act (IPA) within the Department of Energy (DOE) and establishes requirements, responsibilities, and authority for effecting assignments under the Act. Does not cancel other directives.

  5. Handbook on Overseas Assignments

    Broader source: Energy.gov [DOE]

    This handbook covers all types of Federal employment overseas, including details, both within DOE as well as to other agencies; transfers to approved international organizations; assignments to permanent DOE positions; cost-free experts; and personal services agreements (PSAs). This handbook contains information, guidance, sample service agreements, and related documentation that are to be used to implement the departments directives.

  6. SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Evaluation

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Formal Training | Department of Energy Evaluation of Formal Training SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Evaluation of Formal Training Form is used to evaluate formal training courses in the SES program. SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Evaluation of Formal Training (163.2 KB) More Documents & Publications SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Candidate Developmental Assignment Evaluation SENIOR

  7. Program Assignments | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Services » Procurement Services » Program Assignments Program Assignments Office of Headquarters Procurement Services (MA-64) Program Assignments Mark C. Brady, Director,(202) 287-1389 Patricia Davies, Deputy Director, (202) 586-8975 CORPORATE SERVICES OFFICE - Anthony E. Cicala, Director, MA-64.1, (202) 586-7637 Strategic Initiatives Coordinator Competition Advocate Contracting Activity Task/Delivery Order Ombudsman Policy Flashes Independent Review Deborah Black - (202) 287-1416 Balanced

  8. Unclassified Foreign Visits and Assignments

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-06-18

    To define a program for unclassified foreign national access to Department of Energy sites, information, and technologies. This Order cancels DOE P 142.1, Unclassified Foreign Visits and Assignments, dated 7-14-99; DOE N 142.1, Unclassified Foreign Visits and Assignments, dated 7-14-99; Secretarial Memorandum Unclassified Foreign Visits and Assignments, dated 7-14-99; Memorandum from Francis S. Blake, Departmental Use of Foreign Access Central Tracking System, dated 11-05-01; Memorandum from Kyle E. McSlarrow, Interim Guidance for Implementation of the Department's Unclassified Foreign Visits and Assignments Program, dated 12-17-02; and Secretarial Memorandum, Policy Exclusion for Unclassified Foreign National's Access to Department of Energy Facilities in Urgent or Emergency Medical Situations, dated 4-10-01. Cancels: DOE P 142.1 and DOE N 142.1

  9. Unclassified Foreign Visits and Assignments

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-14

    To provide interim Department of Energy (DOE) requirements and responsibilities for unclassified visits and assignment by foreign nationals to DOE facilities for unclassified activities. This Notice supplements DOE P 142.1 dated 7-14-99, which sets overall Departmental policy on unclassified foreign visits and assignments. It is a complement to existing counterintelligence and security orders and policies. DOE N 251.53, dated 05/14/03, extends this directive until canceled. Cancels: DOE 1240.2B

  10. Unclassified Foreign Visits and Assignments

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-14

    International cooperation and collaboration is an important element in the effective planning and implementation of many Department of Energy (DOE) programs. DOE and its international partners benefit from the exchange of information that results from a managed process of unclassified visits and assignments by foreign nationals. These visits and assignments must be conducted in a manner consistent with U.S. and DOE national security policies, requirements, and objectives including export control laws and regulations. Canceled by DOE O 142.3. Does not cancel other directives.

  11. Foreign National Visit/Assignment Questionnaire

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Unclassified Foreign National Visits & Assignments Questionnaire Welcome to Department of Energy, Headquarters We are looking forward to your visit or assignment with us. In ...

  12. Unclassified Foreign National Visits & Assignments Questionnaire |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Services » Calibration Facilities » Unclassified Foreign National Visits & Assignments Questionnaire Unclassified Foreign National Visits & Assignments Questionnaire Visitors who are foreign nationals must complete and submit the Unclassified Foreign National Visits & Assignments Questionnaire 30 days before accessing facilities. Unclassified Foreign National Visits & Assignments Questionnaire (192.5 KB) More Documents & Publications HQ FNVA

  13. Continuous Learning Points Credit Assignment Table | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PDF icon Microsoft Word - CLPCreditAssignmentTable More Documents & Publications PMCDP Curriculum Learning Map Microsoft Word - AL2006-07.doc PMCDP Certification and Equivalency ...

  14. Foreign National Visit/Assignment Questionnaire

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Information (PII) Company Proprietary Information ... areas are to be visited) Property Protection Area with ... and Assignments 47 Is an Export Control License Required? ...

  15. Preparing for Project Implementation Assigning Accountability...

    Broader source: Energy.gov (indexed) [DOE]

    Assigning Accountability for Each Project (April 14, 2010) (598.01 KB) More Documents & Publications Preparing for Project Implementation after an Energy Assessment

  16. JOBAID-LAUNCHING AND COMPLETING ASSIGNED SURVEY

    Broader source: Energy.gov [DOE]

    The purpose of this job aid is to guide users through the step-by-step process of launching and completing assigned surverys.

  17. Organizations' Assignment of Responsibility - DOE Directives,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Delegations, and Requirements Organizations' Assignment of Responsibility Current By Functional Area By Position Designations Assignments Rescinded by Diane Johnson More filters Less filters Filters applied Δ Hide filters ∇ Show filters (0) [X] Remove all Issue Date Start date End date ffe8aa65e5ad705f837fe439ace37780

  18. JOBAID-SELF ASSIGNING COURSES (ITEMS)

    Broader source: Energy.gov [DOE]

    In this jobaid you will learn to use the Course Catalog, Browse Catalog, Recommended Items, Locate and Self-Assign Items (Courses) Using the Search Catalog features, Narrow Course Searches using...

  19. Help:Assigning permissions | Open Energy Information

    Open Energy Info (EERE)

    search "Assigning permissions" means granting users extra rights within the wiki software (or revoking these rights). This is done by going to the Special:UserRights page, and...

  20. Unclassified Foreign National Visits & Assignments Questionnaire

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Unclassified Foreign National Visits & Assignments Questionnaire |Welcome to U.S. Department of Energy Office of Legacy Management! We are looking forward to your visit or assignment with us. In order to comply with our security requirements and ensure that your time with the Department of Energy goes smoothly we need to obtain some information from you prior to your arrival. Please take a few minutes to provide the information requested below for each member of your party that is not a U.S.

  1. Unclassified Foreign Visits and Assignments Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-06-18

    The order defines a program for unclassified foreign national access to Department of Energy sites, information, and technologies. The page change streamlines the HQs Management Panel review process to include reviews by HSS, IN, and a representative of the cognizant under secretary for access requests involving foreign nationals. Cancels Secretarial Memorandum, Unclassified Foreign Visits and Assignments, dated 7-14-99; Memorandum from Francis S. Blake, Departmental Use of Foreign Access Central Tracking System, dated 11-05-01; Memorandum from Kyle E. McSlarrow, Interim Guidance for Implementation of the Department's Unclassified Foreign Visits and Assignments Program, dated 12-17-02; and Secretarial Memorandum, Policy Exclusion for Unclassified Foreign National's Access to Department of Energy Facilities in Urgent or Emergency Medical Situations, dated 4-10-01. Cancels: DOE P 142.1 and DOE N 142.1

  2. Unclassified Foreign National Visits and Assignments

    Broader source: Energy.gov [DOE]

    Attached for your information is a March 9,201 0 Memorandum from the Deputy Secretary relaxing certain check and approval requirements relating to visits and assignments of foreign nationals to DOE facilities and National Laboratories, including National Nuclear Security Administration sites. This is part of an ongoing review of DOE Order 142.3. Please furnish a copy to affected contractors pending revision of the Order and its associated Contractor Requirements Document.

  3. NREL Researcher on Assignment in South Africa

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on Assignment in South Africa For more information contact: e:mail: Public Affairs Golden, Colo., Oct. 20, 1997 -- A policy analyst with the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) is headed to South Africa for eight months of high-level economic research on the South African electricity supply industry. Principal Analyst Paul Galen in NREL's Center for Energy Analysis and Applications will be a visiting researcher with the South African Minerals and Energy

  4. Project Registration Number Assignments (Active) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Active) Project Registration Number Assignments (Active) As of: May 2016 Provides a table of Project Registration Number Assignments (Active) Project Registration Number Assignment (Active) (511.76 KB) More Documents & Publications All Active DOE Technical Standards Document Project Registration Number Assignments (Completed

  5. Project Registration Number Assignments (Completed) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Completed) Project Registration Number Assignments (Completed) As of: May 2016 Provides a table of Project Registration Number Assignments (Completed) Project Registration Number Assignments (Completed) (406.85 KB) More Documents & Publications All Active DOE Technical Standards Document Project Registration Number Assignments (Active

  6. Calibration Pad Assignments for Spectral Gamma (November 1985) | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Pad Assignments for Spectral Gamma (November 1985) Calibration Pad Assignments for Spectral Gamma (November 1985) Calibration Pad Assignments for Spectral Gamma (November 1985) Calibration Pad Assignments for Spectral Gamma (November 1985) (5.3 MB) More Documents & Publications Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984) Field Calibration Facilities for Environmental Measurement of Radium, Thorium, and Potassium (October 2013) Grade

  7. Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (April 1984) | Department of Energy Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984) Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984) Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984) Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984) (3.25 MB) More Documents & Publications Grade Assignments for Models Used for Calibration of Gross-Count

  8. 3210T3 Risk Code Assignment;

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    210 Appendix T3 Risk Code Assignment 1.0 Purpose Identification of work hazards and understanding their risks is an essential part of Jefferson Lab's work process as defined in ES&H Manual Chapter 3210 Appendix T1 Work Planning, Control, and Authorization Procedure. The purpose of this document is to demonstrate the accepted method for determining the Risk Code for task steps identified while completing Task Hazard Analysis (THA) Worksheet. 2.0 Scope This appendix describes the procedure for

  9. Foreign Visits & Assignments Guidelines | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Foreign Visits & Assignments Guidelines Foreign Visits and Assignments Requests (473's) and Specific Security Plans Please use the following links to reach Form 473, the Foreign Visits and Assignments Request Form, as well as the Ames Laboratory Specific Security Plan Form. Form 473 Foreign Visits and Assignments Request Form Specific Security Plan Program Overview. The USDOE considers hosting foreign visitors a critical responsibility. This is especially true when the foreign national is

  10. Recognizing and Assigning ESPC Risks and Responsibilities Using the Risk,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Responsibility, and Performance Matrix | Department of Energy Recognizing and Assigning ESPC Risks and Responsibilities Using the Risk, Responsibility, and Performance Matrix Recognizing and Assigning ESPC Risks and Responsibilities Using the Risk, Responsibility, and Performance Matrix Document offers guidance on how to recognize and assign energy savings performance contract (ESPC) risks and responsibilities using the risk, responsibility, and performance matrix, also known as RRPM.

  11. Measuring the maturity of a technology : guidance on assigning...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: Measuring the maturity of a technology : guidance on assigning a TRL. ... for supplier-customer interactions at a very early stage in technology development. ...

  12. Chief of Nuclear Safety (CNS) Staff Assignments & Expertise ...

    Broader source: Energy.gov (indexed) [DOE]

    Chief of Nuclear Safety (CNS) Staff Assignments & Expertise CNS staff maintains adequate technical proficiency, including the timely completion of Senior Technical Safety Manager...

  13. FOAM (Functional Ontology Assignments for Metagenomes): A Hidden...

    Office of Scientific and Technical Information (OSTI)

    Ontology Assignments for Metagenomes): A Hidden Markov Model (HMM) database with environmental focus Citation Details In-Document Search Title: FOAM (Functional Ontology...

  14. Recognizing and Assigning ESPC Risks and Responsibilities Using...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Using the Risk, Responsibility, and Performance Matrix Recognizing and Assigning ESPC Risks and Responsibilities Using the Risk, Responsibility, and Performance Matrix ...

  15. Acquisition Letter on Contractor Domestic Extended Personnel Assignments

    Broader source: Energy.gov [DOE]

    The attached Acquisition Letter has been issued to provide guidance on the Department's policy governing reimbursement of costs associated with contractor domestic extended personnel assignments.

  16. Evaluation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Savings Portfolio (122013) Energy Smart Grocer Impact Evaluation (102013) Energy Smart Industrial - Energy Management Pilot Impact Evaluation (22013) Clark PUD Home...

  17. Artificial leaf jumps developmental hurdle

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Center Objective The Science Center Publications Graduate Research opportunities Undergraduate research opportunities EFRC-501 graduate class Seminar schedules Center News Research Highlights Center Research News Media about Center Center Video Library Bisfuel Picture Gallery Artificial leaf jumps developmental hurdle 18 Feb 2014 by Jenny Green: In a recent early online edition of Nature Chemistry, ASU scientists, along with colleagues at Argonne National Laboratory, have reported advances

  18. NNSA authorizes mission assignment transfer to Kansas City Plant | National

    National Nuclear Security Administration (NNSA)

    Nuclear Security Administration | (NNSA) authorizes mission assignment transfer to Kansas City Plant Wednesday, June 25, 2014 - 1:05pm To improve efficiency across the nuclear security enterprise, NNSA recently transferred the mission assignment of several product families from Sandia National Laboratories to the Kansas City Plant. The mission reassignment better aligns responsibilities with each site's core competencies and will leverage Kansas City's Supply Chain Management systems and

  19. Statistical methods of spin assignment in compound nuclear reactions

    SciTech Connect (OSTI)

    Mach, H.; Johns, M.W.

    1985-01-15

    Spin assignment to nuclear levels can be obtained from standard in-beam gamma-ray spectroscopy techniques and in the case of compound nuclear reactions can be complemented by statistical methods. These are based on a correlation pattern between level spin and gamma-ray intensities feeding low-lying levels. Three types of intensity and level spin correlations are found suitable for spin assignment: shapes of the excitation functions, ratio of intensity at two beam energies or populated in two different reactions, and feeding distributions. Various empirical attempts are examined and the range of applicability of these methods as well as the limitations associated with them are given.

  20. Electric Utility Company Assigned to a Zip Code? | OpenEI Community

    Open Energy Info (EERE)

    Electric Utility Company Assigned to a Zip Code? Home I have found an error in the utility company assigned to a zip code. I am not sure if the "assigned" utility company covers...

  1. DOE F 360.3 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    3 DOE F 360.3 Form is used to provide basic information about the SES candidate, qualifications, and the assignment. SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Developmental Assignment Opportunity (132.31 KB) More Documents & Publications SESCDP Supervisor's Evaluation of Candidate's Performance During Developmental Assignment SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Candidate Developmental Assignment Evaluation SENIOR EXECUTIVE SERVICE CANDIDATE

  2. Evaluation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and infrastructure R&D through its FreedomCAR and Vehicle Technologies Program to help the United States reduce its dependence on imported petroleum and to pave the way to a future transportation network based on hydrogen. Natural gas vehicles can also reduce emissions of regulated pollutants compared with vehicles powered by conventional fuels such as gasoline and diesel. The goal of this project was to evaluate the safety implications of refueling natural gas vehicles at home with a home

  3. Method for assigning sites to projected generic nuclear power plants

    SciTech Connect (OSTI)

    Holter, G.M.; Purcell, W.L.; Shutz, M.E.; Young, J.R.

    1986-07-01

    Pacific Northwest Laboratory developed a method for forecasting potential locations and startup sequences of nuclear power plants that will be required in the future but have not yet been specifically identified by electric utilities. Use of the method results in numerical ratings for potential nuclear power plant sites located in each of the 10 federal energy regions. The rating for each potential site is obtained from numerical factors assigned to each of 5 primary siting characteristics: (1) cooling water availability, (2) site land area, (3) power transmission land area, (4) proximity to metropolitan areas, and (5) utility plans for the site. The sequence of plant startups in each federal energy region is obtained by use of the numerical ratings and the forecasts of generic nuclear power plant startups obtained from the EIA Middle Case electricity forecast. Sites are assigned to generic plants in chronological order according to startup date.

  4. 2210R1 ES&H Staff Assignments

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    210 Appendix R1 Staff Assigned to ES&H Activities 1.0 Purpose This appendix provides information for current Environmental, Safety and Health (ES&H) related staff positions at Jefferson Lab. Other positions of responsibility are outlined on the various Division & Department's Organization Charts. * Section 2.0 - Contact Information for Hazard Issues * Section 3.0 - Contact Information for Responsible Positions * Section 4.0 - Councils and Committees * Section 5.0 - Division Safety

  5. SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Candidate

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Developmental Assignment Evaluation | Department of Energy Candidate Developmental Assignment Evaluation SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Candidate Developmental Assignment Evaluation Form allows ESE candidates to evaluate assignments in terms of the executive core qualities the assignment was intended to meet, how well it met expectations and provided a learning experience, what prior knowledge or experience might have been adventageous, whether to recommend

  6. SEP Enterprise-Wide Accelerator | Department of Energy

    Energy Savers [EERE]

    Developmental Assignment Evaluation | Department of Energy Candidate Developmental Assignment Evaluation SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Candidate Developmental Assignment Evaluation Form allows ESE candidates to evaluate assignments in terms of the executive core qualities the assignment was intended to meet, how well it met expectations and provided a learning experience, what prior knowledge or experience might have been adventageous, whether to recommend

  7. Automated Pre-processing for NMR Assignments with Reduced Tedium

    Energy Science and Technology Software Center (OSTI)

    2004-05-11

    An important rate-limiting step in the reasonance asignment process is accurate identification of resonance peaks in MNR spectra. NMR spectra are noisy. Hence, automatic peak-picking programs must navigate between the Scylla of reliable but incomplete picking, and the Charybdis of noisy but complete picking. Each of these extremes complicates the assignment process: incomplete peak-picking results in the loss of essential connectivities, while noisy picking conceals the true connectivities under a combinatiorial explosion of false positives.more » Intermediate processing can simplify the assignment process by preferentially removing false peaks from noisy peak lists. This is accomplished by requiring consensus between multiple NMR experiments, exploiting a priori information about NMR spectra, and drawing on empirical statistical distributions of chemical shift extracted from the BioMagResBank. Experienced NMR practitioners currently apply many of these techniques "by hand", which is tedious, and may appear arbitrary to the novice. To increase efficiency, we have created a systematic and automated approach to this process, known as APART. Automated pre-processing has three main advantages: reduced tedium, standardization, and pedagogy. In the hands of experienced spectroscopists, the main advantage is reduced tedium (a rapid increase in the ratio of true peaks to false peaks with minimal effort). When a project is passed from hand to hand, the main advantage is standardization. APART automatically documents the peak filtering process by archiving its original recommendations, the accompanying justifications, and whether a user accepted or overrode a given filtering recommendation. In the hands of a novice, this tool can reduce the stumbling block of learning to differentiate between real peaks and noise, by providing real-time examples of how such decisions are made.« less

  8. Assigning Seismic Design Category to Large Reactors: A Case Study of the ATR

    Broader source: Energy.gov [DOE]

    Assigning Seismic Design Category to Large Reactors: A Case Study of the ATR Stuart Jensen October 21, 2014

  9. Term Assignments of Contractors to the Washington D.C. Area.

    Broader source: Energy.gov [DOE]

    On July 2, 2013 the DOE Office of the Inspector General issued Audit Report Number 0890 entitled, "Follow-up Audit on Term Assignments of Contractor Employees." The audit was conducted as a follow-up of the FY 2005 audit of "Management of Facility Contractors Assigned to the Washington D.C. area DOE/IG 0710." The earlier report found instances where assignment justifications were insufficient, costs appeared excessive and allowances inconsistent. The follow-up audit recognized improved management of assignments but noted assignment justifications and cost management could be improved. The report recommended DOE determine prior year actual costs to assist in calculating the estimated costs for the upcoming year of multi-year assignments and ensure assignment records in the Departmental Management and Tracking System (DMATS) are accurate.

  10. Assignments of the Raman modes of monoclinic erbium oxide

    SciTech Connect (OSTI)

    Yan, D.; Wu, P. Zhang, S. P.; Liang, L.; Yang, F.; Pei, Y. L.; Chen, S.

    2013-11-21

    As a heavy rare earth oxide, erbium oxide (Er{sub 2}O{sub 3}) has many attractive properties. Monoclinic Er{sub 2}O{sub 3} has useful properties not found in stable cubic Er{sub 2}O{sub 3}, such as unique optical properties and high radiation damage tolerance. In this study, cubic Er{sub 2}O{sub 3} coating and Er{sub 2}O{sub 3} coating with mixed phases were prepared. The Raman scattering spectra of these coatings were investigated by using a confocal micro-Raman spectrometer equipped with 325, 473, 514, 532, 633, and 784 nm lasers. A total of 17 first-order Raman modes of monoclinic Er{sub 2}O{sub 3} were identified and assigned. The modes at 83, 112, 152, 170, 278, 290, 409, 446, 478, 521, 603, and 622 cm{sup −1} are of A{sub g} symmetry, whereas modes at 71, 98, 333, 409, 446, and 468 cm{sup −1} are of B{sub g} symmetry. This research provides basic data necessary for the characterization of monoclinic Er{sub 2}O{sub 3} by Raman spectroscopy.

  11. Chief of Nuclear Safety (CNS) Staff Assignments & Expertise | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Chief of Nuclear Safety (CNS) Staff Assignments & Expertise Chief of Nuclear Safety (CNS) Staff Assignments & Expertise Chief of Nuclear Safety (CNS) Staff Assignments & Expertise CNS staff maintains adequate technical proficiency, including the timely completion of Senior Technical Safety Manager (STSM) qualification. Further, CNS staff periodically review and assess whether EM is maintaining adequate numbers of technically competent personnel necessary to fulfill its

  12. Calibration Model Assignments expressed as U3O8, Summary Table ES-1 |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Model Assignments expressed as U3O8, Summary Table ES-1 Calibration Model Assignments expressed as U3O8, Summary Table ES-1 Calibration Model Assignments expressed as U3O8, Summary Table ES-1 Calibration Model Assignments expressed as U3O8, Summary Table ES-1 (25.9 KB) More Documents & Publications Field Calibration Facilities for Environmental Measurement of Radium, Thorium, and Potassium (October 2013) Offshore Wind Market and Economic Analysis Report 2013 Natural

  13. Audit Report - Follow-up Audit on Term Assignments of Contractor...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    when compared to other means of acquiring the necessary knowledge and experience. Our 2005 report on Management of Facility Contractors Assigned to the Washington, DC Area ...

  14. Developmental Control of Lignification in Stems of Lowland Switchgrass...

    Office of Scientific and Technical Information (OSTI)

    Developmental Control of Lignification in Stems of Lowland Switchgrass Variety Alamo and ... Sponsoring Org: USDOE Office of Science (SC), Biological and Environmental Research (BER) ...

  15. Comparative developmental toxicity of environmentally relevant oxygenated PAHs

    SciTech Connect (OSTI)

    Knecht, Andrea L.; Goodale, Britton C.; Truong, Lisa; Simonich, Michael T.; Swanson, Annika J.; Matzke, Melissa M.; Anderson, Kim A.; Waters, Katrina M.; Tanguay, Robert L.

    2013-09-01

    Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are byproducts of combustion and photo-oxidation of parent PAHs. OPAHs are widely present in the environment and pose an unknown hazard to human health. The developing zebrafish was used to evaluate a structurally diverse set of 38 OPAHs for malformation induction, gene expression changes and mitochondrial function. Zebrafish embryos were exposed from 6 to 120 h post fertilization (hpf) to a dilution series of 38 different OPAHs and evaluated for 22 developmental endpoints. AHR activation was determined via CYP1A immunohistochemistry. Phenanthrenequinone (9,10-PHEQ), 1,9-benz-10-anthrone (BEZO), xanthone (XAN), benz(a)anthracene-7,12-dione (7,12-B[a]AQ), and 9,10-anthraquinone (9,10-ANTQ) were evaluated for transcriptional responses at 48 hpf, prior to the onset of malformations. qRT-PCR was conducted for a number of oxidative stress genes, including the glutathione transferase(gst), glutathione peroxidase(gpx), and superoxide dismutase(sod) families. Bioenergetics was assayed to measure in vivo oxidative stress and mitochondrial function in 26 hpf embryos exposed to OPAHs. Hierarchical clustering of the structure-activity outcomes indicated that the most toxic of the OPAHs contained adjacent diones on 6-carbon moieties or terminal, para-diones on multi-ring structures. 5-carbon moieties with adjacent diones were among the least toxic OPAHs while the toxicity of multi-ring structures with more centralized para-diones varied considerably. 9,10-PHEQ, BEZO, 7,12-B[a]AQ, and XAN exposures increased expression of several oxidative stress related genes and decreased oxygen consumption rate (OCR), a measurement of mitochondrial respiration. Comprehensive in vivo characterization of 38 structurally diverse OPAHs indicated differential AHR dependency and a prominent role for oxidative stress in the toxicity mechanisms. - Highlights: OPAHs are byproducts of combustion present in the environment. OPAHs pose a largely

  16. SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    DEVELOPMENT PROGRAM (SESCDP) Candidate Developmental Assignment Evaluation SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Evaluation of Formal Training DOE F 360.3

  17. Unclassified Foreign National Visits and Assignments at Oak Ridge National Laboratory

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Unclassified Foreign National Visits and Assignments at Oak Ridge National Laboratory INS-O-13-05 September 2013 Department of Energy Washington, DC 20585 September 16, 2013 MEMORANDUM FOR THE MANAGER, OAK RIDGE NATIONAL LABORATORY SITE OFFICE FROM: Sandra D. Bruce Assistant Inspector General for Inspections Office of Inspector General SUBJECT: INFORMATION: Inspection Report on "Unclassified Foreign National Visits and Assignments at Oak Ridge National Laboratory" BACKGROUND In support

  18. METHODOLOGY AND CALCULATIONS FOR THE ASSIGNMENT OF WASTE GROUPS FOR THE LARGE UNDERGROUND WASTE STORAGE TANKS AT THE HANFORD SITE

    SciTech Connect (OSTI)

    WEBER RA

    2009-01-16

    group B (or A) tank identifies the potential for an induced flammable gas release hazard, the hazard only exists for specific operations that can release the retained gas in the tank at a rate and quantity that results in reaching 100% of the lower flammability limit in the tank headspace. The identification and evaluation of tank farm operations that could cause an induced flammable gas release hazard in a waste group B (or A) tank are included in other documents. The third criterion is the buoyancy ratio. This criterion addresses tanks that are not waste group C double-shell tanks and have an energy ratio {ge} 3.0. For these double-shell tanks, the buoyancy ratio considers whether the saturated solids can retain sufficient gas to exceed neutral buoyancy relative to the supernatant layer and therefore have buoyant displacement gas release events. If the buoyancy ratio is {ge} 1.0, that double-shell tank is assigned to waste group A. These tanks are considered to have a potential spontaneous buoyant displacement flammable gas release hazard in addition to a potential induced flammable gas release hazard. This document categorizes each of the large waste storage tanks into one of several categories based on each tank's waste characteristics. These waste group assignments reflect a tank's propensity to retain a significant volume of flammable gases and the potential of the waste to release retained gas by a buoyant displacement event. Revision 8 is the annual update of the calculations of the flammable gas Waste Groups for DSTs and SSTs.

  19. METHODOLOGY AND CALCULATIONS FOR THE ASSIGNMENT OF WASTE GROUPS FOR THE LARGE UNDERGROUND WASTE STORAGE TANKS AT THE HANFORD SITE

    SciTech Connect (OSTI)

    FOWLER KD

    2007-12-27

    material and release gas and are assigned to waste group B. These tanks are considered to represent a potential induced flammable gas release hazard, but no spontaneous buoyant displacement flammable gas release hazard. Tanks that are not waste group C tanks and have an energy ratio {ge} 3.0, but that pass the third criterion (buoyancy ratio < 1.0, see below) are also assigned to waste group B. Even though the designation as a waste group B (or A) tank identifies the potential for an induced flammable gas release hazard, the hazard only exists for specific operations that can release the retained gas in the tank at a rate and quantity that results in reaching 100% of the lower flammability limit in the tank headspace. The identification and evaluation of tank farm operations that could cause an induced flammable gas release hazard in a waste group B (or A) tank are included in other documents. The third criterion is the buoyancy ratio. This criterion addresses tanks that are not waste group C double-shell tanks and have an energy ratio {ge} 3.0. For these double-shell tanks, the buoyancy ratio considers whether the saturated solids can retain sufficient gas to exceed neutral buoyancy relative to the supernatant layer and therefore have buoyant displacement gas release events. If the buoyancy ratio is {ge} 1.0, that double-shell tank is assigned to waste group A. These tanks are considered to have a potential spontaneous buoyant displacement flammable gas release hazard in addition to a potential induced flammable gas release hazard.

  20. GENERAL ASSIGNMENT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEA Honors Geothermal Leaders GEA Honors Geothermal Leaders December 9, 2013 - 12:00am Addthis Washington, D.C. (December 9, 2013) The Geothermal Energy Association (GEA) has announced the winners for the GEA Honors, which recognize companies and individuals that have made significant contributions during the past year to advancing technology, spurring economic development and protecting the environment. The winners were selected in categories including Technological Advancement, Economic

  1. Method and system for assigning a confidence metric for automated determination of optic disc location

    DOE Patents [OSTI]

    Karnowski, Thomas P.; Tobin, Jr., Kenneth W.; Muthusamy Govindasamy, Vijaya Priya; Chaum, Edward

    2012-07-10

    A method for assigning a confidence metric for automated determination of optic disc location that includes analyzing a retinal image and determining at least two sets of coordinates locating an optic disc in the retinal image. The sets of coordinates can be determined using first and second image analysis techniques that are different from one another. An accuracy parameter can be calculated and compared to a primary risk cut-off value. A high confidence level can be assigned to the retinal image if the accuracy parameter is less than the primary risk cut-off value and a low confidence level can be assigned to the retinal image if the accuracy parameter is greater than the primary risk cut-off value. The primary risk cut-off value being selected to represent an acceptable risk of misdiagnosis of a disease having retinal manifestations by the automated technique.

  2. Homologous recombination and non-homologous end-joining repair pathways in bovine embryos with different developmental competence

    SciTech Connect (OSTI)

    Henrique Barreta, Marcos; Laboratorio de Biotecnologia e Reproducao Animal-BioRep, Universidade Federal de Santa Maria, Santa Maria, RS ; Garziera Gasperin, Bernardo; Braga Rissi, Vitor; Cesaro, Matheus Pedrotti de; Ferreira, Rogerio; Oliveira, Joao Francisco de; Goncalves, Paulo Bayard Dias; Bordignon, Vilceu

    2012-10-01

    This study investigated the expression of genes controlling homologous recombination (HR), and non-homologous end-joining (NHEJ) DNA-repair pathways in bovine embryos of different developmental potential. It also evaluated whether bovine embryos can respond to DNA double-strand breaks (DSBs) induced with ultraviolet irradiation by regulating expression of genes involved in HR and NHEJ repair pathways. Embryos with high, intermediate or low developmental competence were selected based on the cleavage time after in vitro insemination and were removed from in vitro culture before (36 h), during (72 h) and after (96 h) the expected period of embryonic genome activation. All studied genes were expressed before, during and after the genome activation period regardless the developmental competence of the embryos. Higher mRNA expression of 53BP1 and RAD52 was found before genome activation in embryos with low developmental competence. Expression of 53BP1, RAD51 and KU70 was downregulated at 72 h and upregulated at 168 h post-insemination in response to DSBs induced by ultraviolet irradiation. In conclusion, important genes controlling HR and NHEJ DNA-repair pathways are expressed in bovine embryos, however genes participating in these pathways are only regulated after the period of embryo genome activation in response to ultraviolet-induced DSBs.

  3. The developmental transcriptome of Drosophila melanogaster

    SciTech Connect (OSTI)

    University of Connecticut; Graveley, Brenton R.; Brooks, Angela N.; Carlson, Joseph W.; Duff, Michael O.; Landolin, Jane M.; Yang, Li; Artieri, Carlo G.; van Baren, Marijke J.; Boley, Nathan; Booth, Benjamin W.; Brown, James B.; Cherbas, Lucy; Davis, Carrie A.; Dobin, Alex; Li, Renhua; Lin, Wei; Malone, John H.; Mattiuzzo, Nicolas R.; Miller, David; Sturgill, David; Tuch, Brian B.; Zaleski, Chris; Zhang, Dayu; Blanchette, Marco; Dudoit, Sandrine; Eads, Brian; Green, Richard E.; Hammonds, Ann; Jiang, Lichun; Kapranov, Phil; Langton, Laura; Perrimon, Norbert; Sandler, Jeremy E.; Wan, Kenneth H.; Willingham, Aarron; Zhang, Yu; Zou, Yi; Andrews, Justen; Bicke, Peter J.; Brenner, Steven E.; Brent, Michael R.; Cherbas, Peter; Gingeras, Thomas R.; Hoskins, Roger A.; Kaufman, Thomas C.; Oliver, Brian; Celniker, Susan E.

    2010-12-02

    Drosophila melanogaster is one of the most well studied genetic model organisms; nonetheless, its genome still contains unannotated coding and non-coding genes, transcripts, exons and RNA editing sites. Full discovery and annotation are pre-requisites for understanding how the regulation of transcription, splicing and RNA editing directs the development of this complex organism. Here we used RNA-Seq, tiling microarrays and cDNA sequencing to explore the transcriptome in 30 distinct developmental stages. We identified 111,195 new elements, including thousands of genes, coding and non-coding transcripts, exons, splicing and editing events, and inferred protein isoforms that previously eluded discovery using established experimental, prediction and conservation-based approaches. These data substantially expand the number of known transcribed elements in the Drosophila genome and provide a high-resolution view of transcriptome dynamics throughout development. Drosophila melanogaster is an important non-mammalian model system that has had a critical role in basic biological discoveries, such as identifying chromosomes as the carriers of genetic information and uncovering the role of genes in development. Because it shares a substantial genic content with humans, Drosophila is increasingly used as a translational model for human development, homeostasis and disease. High-quality maps are needed for all functional genomic elements. Previous studies demonstrated that a rich collection of genes is deployed during the life cycle of the fly. Although expression profiling using microarrays has revealed the expression of, 13,000 annotated genes, it is difficult to map splice junctions and individual base modifications generated by RNA editing using such approaches. Single-base resolution is essential to define precisely the elements that comprise the Drosophila transcriptome. Estimates of the number of transcript isoforms are less accurate than estimates of the number of genes

  4. Balance Calibration A Method for Assigning a Direct-Reading Uncertainty to an Electronic Balance.

    SciTech Connect (OSTI)

    Mike Stears

    2010-07-01

    Paper Title: Balance Calibration A method for assigning a direct-reading uncertainty to an electronic balance. Intended Audience: Those who calibrate or use electronic balances. Abstract: As a calibration facility, we provide on-site (at the customers location) calibrations of electronic balances for customers within our company. In our experience, most of our customers are not using their balance as a comparator, but simply putting an unknown quantity on the balance and reading the displayed mass value. Manufacturers specifications for balances typically include specifications such as readability, repeatability, linearity, and sensitivity temperature drift, but what does this all mean when the balance user simply reads the displayed mass value and accepts the reading as the true value? This paper discusses a method for assigning a direct-reading uncertainty to a balance based upon the observed calibration data and the environment where the balance is being used. The method requires input from the customer regarding the environment where the balance is used and encourages discussion with the customer regarding sources of uncertainty and possible means for improvement; the calibration process becomes an educational opportunity for the balance user as well as calibration personnel. This paper will cover the uncertainty analysis applied to the calibration weights used for the field calibration of balances; the uncertainty is calculated over the range of environmental conditions typically encountered in the field and the resulting range of air density. The temperature stability in the area of the balance is discussed with the customer and the temperature range over which the balance calibration is valid is decided upon; the decision is based upon the uncertainty needs of the customer and the desired rigor in monitoring by the customer. Once the environmental limitations are decided, the calibration is performed and the measurement data is entered into a custom

  5. Inhalation developmental toxicology studies: Developmental toxicity of chloroprene vapors in New Zealand white rabbits. Final report

    SciTech Connect (OSTI)

    Mast, T.J.; Evanoff, J.J.; Westerberg, R.B.; Rommereim, R.L.; Weigel, R.J.

    1994-04-01

    Chloroprene, 2-chloro-1,3-butadiene, is a colorless liquid with a pungent ethereal odor that is primarily used as an intermediate in the manufacture of neoprene rubber, and has been used as such since about 1930. This study addressed the potential for chloroprene to cause developmental toxicity in New Zealand white rabbits following gestational exposure to 0, 10, 40, or 175 ppm chloroprene vapors, 6h/dy, 7dy/wk. Each treatment group consisted of 15 artificially inseminated females exposed on 6 through 28 days of gestation (dg). Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice on 29 dg. Implants were enumerated and their status recorded and live fetuses were examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. There were no overt signs of maternal toxicity and the change in maternal body weight over the course of the study was not affected. Exposure of pregnant rabbits to chloroprene vapors on 6-28 dg had no effect on the number of implantation, the mean percent of live pups per litter, or on the incidence of resorptions per litter. The incidence of fetal malformations was not increased by exposure to chloroprene. Results of this study indicate that gestational exposure of New Zealand white rabbits to 10, 40, or 175 ppm chloroprene did not result in observable toxicity to either the dam or the offspring.

  6. Manual of functions, assignments, and responsibilities for nuclear safety: Revision 2

    SciTech Connect (OSTI)

    Not Available

    1994-10-15

    The FAR Manual is a convenient easy-to-use collection of the functions, assignments, and responsibilities (FARs) of DOE nuclear safety personnel. Current DOE directives, including Orders, Secretary of Energy Notices, and other assorted policy memoranda, are the source of this information and form the basis of the FAR Manual. Today, the majority of FARs for DOE personnel are contained in DOE`s nuclear safety Orders. As these Orders are converted to rules in the Code of Federal Regulations, the FAR Manual will become the sole source for information relating to the functions, assignments, responsibilities of DOE nuclear safety personnel. The FAR Manual identifies DOE directives that relate to nuclear safety and the specific DOE personnel who are responsible for implementing them. The manual includes only FARs that have been extracted from active directives that have been approved in accordance with the procedures contained in DOE Order 1321.1B.

  7. Creative solutions for complex developmental testing

    SciTech Connect (OSTI)

    1993-07-01

    Sandia National Laboratories was requested to establish the FAA Aging Aircraft Nondestructive Inspection (NDI) Development and Demonstration Center. The Center is housed in a hangar at the Albuquerque International Airport and owns its own aged transport airplane. The Center`s work encompasses research and development in enhanced structural inspection. The goals of the Center are to: promote NDI technology development and maturation; help transfer new nondevelopment item technology to the hangar floor; validate NDI techniques; assess reliability or probability of detection of NDI processes. An important part of this project will be to make sure that the cost of implementation and operation of any technique is seriously considered and that techniques are usable in the field. Among the initial techniques to be evaluated are: enhanced visual, magneto-optic eddy current; coherent optics; ultrasonics; thermographics; eddy current scanners; experimental modal analysis. This project is a perfect example of how Development Testing draws on its own resources and teams up with others, as necessary, to get the job done. In this case, New Mexico State University and a private company, Science Applications International Corporation, are assisting.

  8. Developmental defects in zebrafish for classification of EGF pathway inhibitors

    SciTech Connect (OSTI)

    Pruvot, Benoist; Cur, Yoann; Djiotsa, Joachim; Voncken, Audrey; Muller, Marc

    2014-01-15

    One of the major challenges when testing drug candidates targeted at a specific pathway in whole animals is the discrimination between specific effects and unwanted, off-target effects. Here we used the zebrafish to define several developmental defects caused by impairment of Egf signaling, a major pathway of interest in tumor biology. We inactivated Egf signaling by genetically blocking Egf expression or using specific inhibitors of the Egf receptor function. We show that the combined occurrence of defects in cartilage formation, disturbance of blood flow in the trunk and a decrease of myelin basic protein expression represent good indicators for impairment of Egf signaling. Finally, we present a classification of known tyrosine kinase inhibitors according to their specificity for the Egf pathway. In conclusion, we show that developmental indicators can help to discriminate between specific effects on the target pathway from off-target effects in molecularly targeted drug screening experiments in whole animal systems. - Highlights: We analyze the functions of Egf signaling on zebrafish development. Genetic blocking of Egf expression causes cartilage, myelin and circulatory defects. Chemical inhibition of Egf receptor function causes similar defects. Developmental defects can reveal the specificity of Egf pathway inhibitors.

  9. The role of high-level calculations in the assignment of the Q-band spectra of chlorophyll

    SciTech Connect (OSTI)

    Reimers, Jeffrey R.; Cai, Zheng-Li; Kobayashi, Rika; Rtsep, Margus; Freiberg, Arvi; Krausz, Elmars

    2014-10-06

    We recently established a novel assignment of the visible absorption spectrum of chlorophyll-a that sees the two components Q{sub x} and Q{sub y} of the low-energy Q band as being intrinsically mixed by non-adiabatic coupling. This ended 50 years debate as to the nature of the Q bands, with prior discussion poised only in the language of the Born-Oppenheimer and Condon approximations. The new assignment presents significant ramifications for exciton transport and quantum coherence effects in photosystems. Results from state of the art electronic structure calculations have always been used to justify assignments, but quantitative inaccuracies and systematic failures have historically limited usefulness. We examine the role of CAM-B3LYP time-dependent density-functional theory (TD-DFT) and Symmetry Adapted Cluster-Configuration Interaction (SAC-CI) calculations in first showing that all previous assignments were untenable, in justifying the new assignment, in making some extraordinary predictions that were vindicated by the new assignment, and in then identifying small but significant anomalies in the extensive experimental data record.

  10. Quadratic partial eigenvalue assignment in large-scale stochastic dynamic systems for resilient and economic design

    SciTech Connect (OSTI)

    Das, Sonjoy; Goswami, Kundan; Datta, Biswa N.

    2014-12-10

    Failure of structural systems under dynamic loading can be prevented via active vibration control which shifts the damped natural frequencies of the systems away from the dominant range of loading spectrum. The damped natural frequencies and the dynamic load typically show significant variations in practice. A computationally efficient methodology based on quadratic partial eigenvalue assignment technique and optimization under uncertainty has been formulated in the present work that will rigorously account for these variations and result in an economic and resilient design of structures. A novel scheme based on hierarchical clustering and importance sampling is also developed in this work for accurate and efficient estimation of probability of failure to guarantee the desired resilience level of the designed system. Numerical examples are presented to illustrate the proposed methodology.

  11. FOAM (Functional Ontology Assignments for Metagenomes): A Hidden Markov Model (HMM) database with environmental focus

    SciTech Connect (OSTI)

    Prestat, Emmanuel; David, Maude M.; Hultman, Jenni; Ta , Neslihan; Lamendella, Regina; Dvornik, Jill; Mackelprang, Rachel; Myrold, David D.; Jumpponen, Ari; Tringe, Susannah G.; Holman, Elizabeth; Mavromatis, Konstantinos; Jansson, Janet K.

    2014-09-26

    A new functional gene database, FOAM (Functional Ontology Assignments for Metagenomes), was developed to screen environmental metagenomic sequence datasets. FOAM provides a new functional ontology dedicated to classify gene functions relevant to environmental microorganisms based on Hidden Markov Models (HMMs). Sets of aligned protein sequences (i.e. ‘profiles’) were tailored to a large group of target KEGG Orthologs (KOs) from which HMMs were trained. The alignments were checked and curated to make them specific to the targeted KO. Within this process, sequence profiles were enriched with the most abundant sequences available to maximize the yield of accurate classifier models. An associated functional ontology was built to describe the functional groups and hierarchy. FOAM allows the user to select the target search space before HMM-based comparison steps and to easily organize the results into different functional categories and subcategories. FOAM is publicly available at http://portal.nersc.gov/project/m1317/FOAM/.

  12. Infrared and Raman spectra, DFT-calculations and spectral assignments of germacyclohexane

    SciTech Connect (OSTI)

    Aleksa, V. Ozerenskis, D.; Pucetaite, M.; Sablinskas, V.; Cotter, C.; Guirgis, G. A.

    2015-03-30

    Raman spectra of germacyclohexane in liquid and solid states were recorded and depolarization data obtained. Infrared absorption spectra of the vapor and liquid have been studied. The wavenumbers of the vibrational modes were derived in the harmonic and anharmonic approximation in B3LYP/ccpVTZ calculations. According to the calculations, germacyclohexane exists in the stable chair conformation, whereas a possible twist form should have more than 15 kJ·mol{sup -1} higher enthalpy of formation what makes this conformer experimentally not observable. The 27 A' and 21 A'' fundamentals were assigned on the basis of the calculations and infrared and Raman band intensities, contours of gas phase infrared spectral bands and Raman depolarization measurements. An average discrepancy of ca. 0.77 % was found between the observed and the calculated anharmonic wavenumbers for the 48 modes. Substitution of carbon atom with Ge atom in the cyclohexane ring is reasoning flattening of the ring.

  13. Spatial assignment of symmetry adapted perturbation theory interaction energy components: The atomic SAPT partition

    SciTech Connect (OSTI)

    Parrish, Robert M.; Sherrill, C. David

    2014-07-28

    We develop a physically-motivated assignment of symmetry adapted perturbation theory for intermolecular interactions (SAPT) into atom-pairwise contributions (the A-SAPT partition). The basic precept of A-SAPT is that the many-body interaction energy components are computed normally under the formalism of SAPT, following which a spatially-localized two-body quasiparticle interaction is extracted from the many-body interaction terms. For electrostatics and induction source terms, the relevant quasiparticles are atoms, which are obtained in this work through the iterative stockholder analysis (ISA) procedure. For the exchange, induction response, and dispersion terms, the relevant quasiparticles are local occupied orbitals, which are obtained in this work through the Pipek-Mezey procedure. The local orbital atomic charges obtained from ISA additionally allow the terms involving local orbitals to be assigned in an atom-pairwise manner. Further summation over the atoms of one or the other monomer allows for a chemically intuitive visualization of the contribution of each atom and interaction component to the overall noncovalent interaction strength. Herein, we present the intuitive development and mathematical form for A-SAPT applied in the SAPT0 approximation (the A-SAPT0 partition). We also provide an efficient series of algorithms for the computation of the A-SAPT0 partition with essentially the same computational cost as the corresponding SAPT0 decomposition. We probe the sensitivity of the A-SAPT0 partition to the ISA grid and convergence parameter, orbital localization metric, and induction coupling treatment, and recommend a set of practical choices which closes the definition of the A-SAPT0 partition. We demonstrate the utility and computational tractability of the A-SAPT0 partition in the context of side-on cation-π interactions and the intercalation of DNA by proflavine. A-SAPT0 clearly shows the key processes in these complicated noncovalent interactions, in

  14. Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects.

    SciTech Connect (OSTI)

    Kodavanti, Prasada; Coburn, Cary; Moser, Virginia; MacPhail, Robert; Fenton, Suzanne; Stoker, Tammy; Birnbaum, Linda

    2010-06-01

    Developmental effects of polybrominated diphenyl ethers (PBDEs) have been suspected due to their structural similarities to polychlorinated biphenyls (PCBs). This study evaluated neurobehavioral, hormonal, and reproductive effects in rat offspring perinatally exposed to a widely used pentabrominated commercial mixture, DE-71. Pregnant Long-Evans rats were exposed to 0, 1.7, 10.2, or 30.6 mg/kg/day DE-71 in corn oil by oral gavage from gestational day 6 to weaning. DE-71 did not alter maternal or male offspring body weights. However, female offspring were smaller compared with controls from postnatal days (PNDs) 35-60. Although several neurobehavioral endpoints were assessed, the only statistically significant behavioral finding was a dose-by-age interaction in the number of rears in an open-field test. Developmental exposure to DE-71 caused severe hypothyroxinemia in the dams and early postnatal offspring. DE-71 also affected anogenital distance and preputial separation in male pups. Body weight gain over time, reproductive tissue weights, and serum testosterone concentrations at PND 60 were not altered. Mammary gland development of female offspring was significantly affected at PND 21. Congener-specific analysis of PBDEs indicated accumulation in all tissues examined. Highest PBDE concentrations were found in fat including milk, whereas blood had the lowest concentrations on a wet weight basis. PBDE concentrations were comparable among various brain regions. Thus, perinatal exposure to DE-71 leads to accumulation of PBDE congeners in various tissues crossing blood-placenta and blood-brain barriers, causing subtle changes in some parameters of neurobehavior and dramatic changes in circulating thyroid hormone levels, as well as changes in both male and female reproductive endpoints. Some of these effects are similar to those seen with PCBs, and the persistence of these changes requires further investigation.

  15. Questions concerning DOE's assignment of operating and testing responsibilities for OTEC-1

    SciTech Connect (OSTI)

    Not Available

    1981-06-30

    OTEC is one of the potential energy sources being developed to provide alternatives for reducing the Nation's dependence on imported oil. When developed, OTEC is to use the temperature variants of the ocean to produce electricity and energy intensive products. OTEC-1 is a major part of DOE's developmental program for OTEC. It is a floating test facility designed primarily for conducting sea tests of the cleanability and performance of heat exchangers, a major component of OTEC systems. Related OTEC subsystems are also being tested. OTEC-1 was to be accomplished in three phases; design (phase I); construction (phase II); and operations and testing (phase III). In July 1977, DOE contracted with TRW, Inc. to design and develop the heat exchanger to be used on OTEC-1. In September 1978, DOE contracted with Global Marine to refurbish, retrofit, and deploy an old Navy ship with OTEC subsystems including TRW's heat exchanger. Together Global Marine and TRW were the OTEC-1 design and construction contractors for phases I and II with Global Marine having overall responsibility for integrating its and TRW's work. Global Marine's contract also included an option for performing work in phase III.

  16. Grade Assignments for Models Used for Calibration of Gross-Count...

    Broader source: Energy.gov (indexed) [DOE]

    Logging Methods for Exploration and Evaluation of Uranium Deposits (1967) Field Calibration Facilities for Environmental Measurement of Radium, Thorium, and Potassium (October 2013

  17. Assigning unique identification numbers to new user accounts and groups in a computing environment with multiple registries

    DOE Patents [OSTI]

    DeRobertis, Christopher V.; Lu, Yantian T.

    2010-02-23

    A method, system, and program storage device for creating a new user account or user group with a unique identification number in a computing environment having multiple user registries is provided. In response to receiving a command to create a new user account or user group, an operating system of a clustered computing environment automatically checks multiple registries configured for the operating system to determine whether a candidate identification number for the new user account or user group has been assigned already to one or more existing user accounts or groups, respectively. The operating system automatically assigns the candidate identification number to the new user account or user group created in a target user registry if the checking indicates that the candidate identification number has not been assigned already to any of the existing user accounts or user groups, respectively.

  18. FOAM (Functional Ontology Assignments for Metagenomes): A Hidden Markov Model (HMM) database with environmental focus

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Prestat, Emmanuel; David, Maude M.; Hultman, Jenni; Ta , Neslihan; Lamendella, Regina; Dvornik, Jill; Mackelprang, Rachel; Myrold, David D.; Jumpponen, Ari; Tringe, Susannah G.; et al

    2014-09-26

    A new functional gene database, FOAM (Functional Ontology Assignments for Metagenomes), was developed to screen environmental metagenomic sequence datasets. FOAM provides a new functional ontology dedicated to classify gene functions relevant to environmental microorganisms based on Hidden Markov Models (HMMs). Sets of aligned protein sequences (i.e. ‘profiles’) were tailored to a large group of target KEGG Orthologs (KOs) from which HMMs were trained. The alignments were checked and curated to make them specific to the targeted KO. Within this process, sequence profiles were enriched with the most abundant sequences available to maximize the yield of accurate classifier models. An associatedmore » functional ontology was built to describe the functional groups and hierarchy. FOAM allows the user to select the target search space before HMM-based comparison steps and to easily organize the results into different functional categories and subcategories. FOAM is publicly available at http://portal.nersc.gov/project/m1317/FOAM/.« less

  19. Quantitative IR Spectrum and Vibrational Assignments for Glycolaldehyde Vapor: Glycolaldehyde Measurements in Biomass Burning Plumes

    SciTech Connect (OSTI)

    Johnson, Timothy J.; Sams, Robert L.; Profeta, Luisa T.; Akagi, Sheryl; Burling, Ian R.; Yokelson, Robert J.; Williams, Stephen D.

    2013-04-15

    Glycolaldehyde (GA, 2-hydroxyethanal, C2H4O2) is a semi-volatile molecule of atmospheric importance, recently proposed as a precursor in the formation of aqueous-phase secondary organic aerosol (SOA). There are few methods to measure glycolaldehyde vapor, but infrared spectroscopy has been used successfully. Using vetted protocols we have completed the first assignment of all fundamental vibrational modes and derived quantitative IR absorption band strengths using both neat and pressure-broadened GA vapor. Even though GA is problematic due to its propensity to both dimerize and condense, our intensities agree well with the few previously published values. Using the reference ?10 band Q-branch at 860.51 cm-1, we have also determined GA mixing ratios in biomass burning plumes generated by field and laboratory burns of fuels from the southeastern and southwestern United States, including the first field measurements of glycolaldehyde in smoke. The GA emission factors were anti-correlated with modified combustion efficiency confirming release of GA from smoldering combustion. The GA emission factors (g of GA emitted per kg dry biomass burned on a dry mass basis) had a low dependence on fuel type consistent with the production mechanism being pyrolysis of cellulose. GA was emitted at 0.23 0.13% of CO from field fires and we calculate that it accounts for ~18% of the aqueous-phase SOA precursors that we were able to measure.

  20. Acquisition Guide Chapter 4.6- Assigning Identifying Numbers Outside of the Strategic Integrated Procurement Enterprise System (STRIPES)

    Broader source: Energy.gov [DOE]

    The subject guide chapter provides guidance on the DOE's procedures for assigning identifying numbers to all new requisitions, solicitations and business instruments processed outside of STRIPES. This Guide Chapter does not apply to instrument numbers issued and business instruments awarded prior to the deployment of STRIPES at the DOE.

  1. Developmental long trace profiler using optimally aligned mirror based pentaprism

    SciTech Connect (OSTI)

    Barber, Samuel K; Morrison, Gregory Y; Yashchuk, Valeriy V; Gubarev, Mikhail V; Geckeler, Ralf D.; Buchheim, Jana; Siewert, Frank; Zeschke, Thomas

    2010-12-20

    A low-budget surface slope measuring instrument, the Developmental Long Trace Profiler (DLTP), was recently brought into operation at the Advanced Light Source Optical Metrology Laboratory. The instrument is based on a precisely calibrated autocollimator and a movable pentaprism. The capability of the DLTP to achieve sub-microradian surface slope metrology has been verified via cross-comparison measurements with other high-performance slope measuring instruments when measuring the same high-quality test optics. In the present work, a further improvement of the DLTP is achieved by replacing the existing bulk pentaprism with a specially designed mirror based pentaprism. A mirror based pentaprism offers the possibility to eliminate systematic errors introduced by inhomogeneity of the optical material and fabrication imperfections of a bulk pentaprism. We provide the details of the mirror based pentaprism design and describe an original experimental procedure for precision mutual alignment of the mirrors. The algorithm of the alignment procedure and its efficiency are verified with rigorous ray tracing simulations. Results of measurements of a spherically curved test mirror and a flat test mirror using the original bulk pentaprism are compared with measurements using the new mirror based pentaprism, demonstrating the improved performance.

  2. Inhalation developmental toxicology studies: Gallium arsenide in mice and rats

    SciTech Connect (OSTI)

    Mast, T.J.; Greenspan, B.J.; Dill, J.A.; Stoney, K.H.; Evanoff, J.J.; Rommereim, R.L.

    1990-12-01

    Gallium arsenide is a crystalline compound used extensively in the semiconductor industry. Workers preparing solar cells and gallium arsenide ingots and wafers are potentially at risk from the inhalation of gallium arsenide dust. The potential for gallium arsenide to cause developmental toxicity was assessed in Sprague- Dawley rats and CD-1 (Swiss) mice exposed to 0, 10, 37, or 75 mg/m{sup 3} gallium arsenide, 6 h/day, 7 days/week. Each of the four treatment groups consisted of 10 virgin females (for comparison), and {approx}30 positively mated rats or {approx}24 positively mated mice. Mice were exposed on 4--17 days of gestation (dg), and rats on 4--19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. Gallium and arsenic concentrations were determined in the maternal blood and uterine contents of the rats (3/group) at 7, 14, and 20 dg. 37 refs., 11 figs., 30 tabs.

  3. Inhalation developmental toxicology studies: Acetonitrile in rats. Final report

    SciTech Connect (OSTI)

    Mast, T.J.; Weigel, R.J.; Westerberg, R.B.; Boyd, P.J.; Hayden, B.K.; Evanoff, J.J.; Rommereim, R.L.

    1994-02-01

    The potential for acetonitrile to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 100, 400, or 1200 ppM acetonitrile, 6 hours/day, 7 days/week. Exposure of rats to these concentrations of acetonitrile resulted in mortality in the 1200 ppM group (2/33 pregnant females; 1/10 non-pregnant females). However, there were no treatment-related effects upon body weights or reproduction indices at any exposure level, nor was there a significant increase in the incidence of fetal malformations or variations. The only effect observed in the fetuses was a slight, but not statiscally significant, exposure-correlated increase in the incidence of supernumerary ribs. Determination of acetonitrile and cyanide concentrations in maternal rat blood showed that acetonitrile concentration in the blood increased with exposure concentration for all exposed maternal rats. Detectable amounts of cyanide in the blood were found only in the rats exposed to 1200 ppM acetonitrile ({approximately}2 {mu}g cyanide/g of blood).

  4. Arranging Prescription Drug Coverage for Extended Stays (Travel or Long-Term Work Assignments) When Outside the United States

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Arranging Prescription Drug Coverage for Extended Stays (Travel or Long-Term Work Assignments) When Outside the United States Planning an extended vacation or working abroad? rx_lanl_override_0311 Maintaining prescription coverage and accessing care for long-term stays abroad What you need to know about override requests and obtaining Rx drugs. Your BCBSNM prescription drug coverage limits override requests to a 90-day supply. Override requests cannot be approved - and are not available -

  5. Evaluation of the DHCE Experiment

    SciTech Connect (OSTI)

    Greenwood, Lawrence R.; Baldwin, David L.; Hollenberg, Glenn W.; Kurtz, Richard J.

    2002-03-31

    The Dynamic Helium Charging Experiment (DHCE) experiment was conducted in the Fast Flux Test Facility (FFTF) during cycle 12, which was completed in 1992. The purpose of the experiment was to enhance helium generation in vanadium alloys to simulate fusion reactor helium-to-dpa ratios with a target goal of 4-5 appm He/dpa. The Fusion Materials Science Program is considering mounting another experiment in hopes of gathering additional data on the effect of helium on the mechanical and physical properties of vanadium structural materials. Pacific Northwest National Laboratory was assigned the task of evaluating the feasibility of conducting another DHCE experiment by carefully evaluating the results obtained of the first DHCE experiment. This report summarizes the results of our evaluation and presents recommendations for consideration by the Materials Science Coordinators Organization.

  6. NbF{sub 5} and TaF{sub 5}: Assignment of {sup 19}F NMR resonances and chemical bond analysis from GIPAW calculations

    SciTech Connect (OSTI)

    Biswal, Mamata; Body, Monique; Legein, Christophe; Sadoc, Aymeric; Boucher, Florent

    2013-11-15

    The {sup 19}F isotropic chemical shifts (?{sub iso}) of two isomorphic compounds, NbF{sub 5} and TaF{sub 5}, which involve six nonequivalent fluorine sites, have been experimentally determined from the reconstruction of 1D {sup 19}F MAS NMR spectra. In parallel, the corresponding {sup 19}F chemical shielding tensors have been calculated using the GIPAW method for both experimental and DFT-optimized structures. Furthermore, the [M{sub 4}F{sub 20}] units of NbF{sub 5} and TaF{sub 5} being held together by van der Waals interactions, the relevance of Grimme corrections to the DFT optimization processes has been evaluated. However, the semi-empirical dispersion correction term introduced by such a method does not show any significant improvement. Nonetheless, a complete and convincing assignment of the {sup 19}F NMR lines of NbF{sub 5} and TaF{sub 5} is obtained, ensured by the linearity between experimental {sup 19}F ?{sub iso} values and calculated {sup 19}F isotropic chemical shielding ?{sub iso} values. The effects of the geometry optimizations have been carefully analyzed, confirming among other matters, the inaccuracy of the experimental structure of NbF{sub 5}. The relationships between the fluorine chemical shifts, the nature of the fluorine atoms (bridging or terminal), the position of the terminal ones (opposite or perpendicular to the bridging ones), the fluorine charges, the ionicity and the length of the MF bonds have been established. Additionally, for three of the {sup 19}F NMR lines of NbF{sub 5}, distorted multiplets, arising from {sup 1}J-coupling and residual dipolar coupling between the {sup 19}F and {sup 93}Nb nuclei, were simulated yielding to values of {sup 93}Nb{sup 19}F {sup 1}J-coupling for the corresponding fluorine sites. - Graphical abstract: The complete assignment of the {sup 19}F NMR lines of NbF{sub 5} and TaF{sub 5} allow establishing relationships between the {sup 19}F ?{sub iso} values, the nature of the fluorine atoms (bridging or

  7. A Bayesian method for using simulator data to enhance human error probabilities assigned by existing HRA methods

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Groth, Katrina M.; Smith, Curtis L.; Swiler, Laura P.

    2014-04-05

    In the past several years, several international agencies have begun to collect data on human performance in nuclear power plant simulators [1]. This data provides a valuable opportunity to improve human reliability analysis (HRA), but there improvements will not be realized without implementation of Bayesian methods. Bayesian methods are widely used in to incorporate sparse data into models in many parts of probabilistic risk assessment (PRA), but Bayesian methods have not been adopted by the HRA community. In this article, we provide a Bayesian methodology to formally use simulator data to refine the human error probabilities (HEPs) assigned by existingmore » HRA methods. We demonstrate the methodology with a case study, wherein we use simulator data from the Halden Reactor Project to update the probability assignments from the SPAR-H method. The case study demonstrates the ability to use performance data, even sparse data, to improve existing HRA methods. Furthermore, this paper also serves as a demonstration of the value of Bayesian methods to improve the technical basis of HRA.« less

  8. A Bayesian method for using simulator data to enhance human error probabilities assigned by existing HRA methods

    SciTech Connect (OSTI)

    Katrinia M. Groth; Curtis L. Smith; Laura P. Swiler

    2014-08-01

    In the past several years, several international organizations have begun to collect data on human performance in nuclear power plant simulators. The data collected provide a valuable opportunity to improve human reliability analysis (HRA), but these improvements will not be realized without implementation of Bayesian methods. Bayesian methods are widely used to incorporate sparse data into models in many parts of probabilistic risk assessment (PRA), but Bayesian methods have not been adopted by the HRA community. In this paper, we provide a Bayesian methodology to formally use simulator data to refine the human error probabilities (HEPs) assigned by existing HRA methods. We demonstrate the methodology with a case study, wherein we use simulator data from the Halden Reactor Project to update the probability assignments from the SPAR-H method. The case study demonstrates the ability to use performance data, even sparse data, to improve existing HRA methods. Furthermore, this paper also serves as a demonstration of the value of Bayesian methods to improve the technical basis of HRA.

  9. Fluoride-elicited developmental testicular toxicity in rats: Roles of endoplasmic reticulum stress and inflammatory response

    SciTech Connect (OSTI)

    Zhang, Shun; Jiang, Chunyang; Liu, Hongliang; Guan, Zhizhong; Zeng, Qiang; Zhang, Cheng; Lei, Rongrong; Xia, Tao; Gao, Hui; Yang, Lu; Chen, Yihu; Wu, Xue; Zhang, Xiaofei; Cui, Yushan; Yu, Linyu; Wang, Zhenglun; Wang, Aiguo

    2013-09-01

    Long-term excessive fluoride intake is known to be toxic and can damage a variety of organs and tissues in the human body. However, the molecular mechanisms underlying fluoride-induced male reproductive toxicity are not well understood. In this study, we used a rat model to simulate the situations of human exposure and aimed to evaluate the roles of endoplasmic reticulum (ER) stress and inflammatory response in fluoride-induced testicular injury. SpragueDawley rats were administered with sodium fluoride (NaF) at 25, 50 and 100 mg/L via drinking water from pre-pregnancy to gestation, birth and finally to post-puberty. And then the testes of male offspring were studied at 8 weeks of age. Our results demonstrated that fluoride treatment increased MDA accumulation, decreased SOD activity, and enhanced germ cell apoptosis. In addition, fluoride elevated mRNA and protein levels of glucose-regulated protein 78 (GRP78), inositol requiring ER-to-nucleus signal kinase 1 (IRE1), and C/EBP homologous protein (CHOP), indicating activation of ER stress signaling. Furthermore, fluoride also induced testicular inflammation, as manifested by gene up-regulation of tumor necrosis factor-? (TNF-?), interleukin-1? (IL-1?), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in a nuclear factor-?B (NF-?B)-dependent manner. These were associated with marked histopathological lesions including injury of spermatogonia, decrease of spermatocytes and absence of elongated spermatids, as well as severe ultrastructural abnormalities in testes. Taken together, our results provide compelling evidence that ER stress and inflammation would be novel and significant mechanisms responsible for fluoride-induced disturbance of spermatogenesis and germ cell loss in addition to oxidative stress. - Highlights: We used a rat model to simulate the situations of human fluoride (F) exposure. Developmental F exposure induces testicular damage related with oxidative stress. Endoplasmic

  10. A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age

    SciTech Connect (OSTI)

    Jusko, Todd A.; De Roos, Anneclaire J.; Schwartz, Stephen M.; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA ; Paige Lawrence, B.; Palkovicova, Lubica; Nemessanyi, Tomas; Drobna, Beata; Fabisikova, Anna; Kocan, Anton; Sonneborn, Dean; Jahnova, Eva; Kavanagh, Terrance J.; Trnovec, Tomas; Hertz-Picciotto, Irva

    2010-05-15

    Background: Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study. Methods: The study population was 384 mother-infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infant PCB concentrations and the antibody concentrations evaluated at 6-months of age. Results: Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener. Conclusions: At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age.

  11. Reproductive and developmental health risk from dioxin-like compounds: Insignificant risk from cement kilns burning waste-derived fuels

    SciTech Connect (OSTI)

    Holcomb, L.C.; Pedelty, J.F.

    1994-12-31

    Cement kilns burning waste-derived fuels emit low levels of dibenzodioxins and dibenzofurans and little or no PCB`s. Concern about possible effects on reproduction and development has prompted an evaluation of the research literature especially with regard to the reproductive and developmental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In sufficient doses, dioxins, furans, and PCB can cause adverse health effects in some animals or humans. Calculated doses of TCDD-EQ (dioxin equivalents) are dependent on many assumptions, but where human effects have been demonstrated, doses were 100--1,000 times higher than the usual background environmental doses. This would include those environmental doses that would be received by the most-exposed individual living near cement kilns burning WDF. There is evidence to suggest that PCB`s have had an adverse impact on some wildlife although there is no evidence that these PCB`s are associated with cement kiln emissions. There is no evidence to suggest that dioxins, at environmental levels or associated with emissions from WDF-burning cement kilns, have caused adverse effects in either wildlife or humans. 63 refs., 3 tabs.

  12. Nonlinear, noniterative, single-distance phase retrieval and developmental biology

    SciTech Connect (OSTI)

    Moosmann, Julian; Altapova, Venera; Haenschke, Daniel; Hofmann, Ralf; Baumbach, Tilo

    2012-05-17

    For coherent X-ray imaging, based on phase contrast through free-space Fresnel propagation, we discuss two noniterative, nonlinear approaches to the phase-retrieval problem from a single-distance intensity map of a pure-phase object. On one hand, a perturbative set-up is proposed where nonlinear corrections to the linearized transport-of-intensity situation are expanded in powers of the object-detector distance z and are evaluated in terms of the linear estimate. On the other hand, a nonperturbative projection algorithm, which is based on the (linear and local) contrast-transfer function (CTF), works with an effective phase in Fourier space. This effective phase obeys a modified CTF relation between intensity contrast at z > 0 and phase contrast at z= 0: Unphysical singularities of the local CTF model are cut off to yield 'quasiparticles' in analogy to the theory of the Fermi liquid. By identifying the positions of the zeros of the Fourier transformed intensity contrast as order parameters for the dynamical breaking of scaling symmetry we investigate the phase structure of the forward-propagation problem when interpreted as a statistical system. Results justify the quasiparticle approach for a wide range of intermediary phase variations. The latter algorithm is applied to data from biological samples recorded at the beamlines TopoTomo and ID19 at ANKA and ESRF, respectively.

  13. METHODOLOGY & CALCULATIONS FOR THE ASSIGNMENT OF WASTE GROUPS FOR THE LARGE UNDERGROUND WASTE STORAGE TANKS AT THE HANFORD SITE

    SciTech Connect (OSTI)

    BARKER, S.A.

    2006-07-27

    Waste stored within tank farm double-shell tanks (DST) and single-shell tanks (SST) generates flammable gas (principally hydrogen) to varying degrees depending on the type, amount, geometry, and condition of the waste. The waste generates hydrogen through the radiolysis of water and organic compounds, thermolytic decomposition of organic compounds, and corrosion of a tank's carbon steel walls. Radiolysis and thermolytic decomposition also generates ammonia. Nonflammable gases, which act as dilutents (such as nitrous oxide), are also produced. Additional flammable gases (e.g., methane) are generated by chemical reactions between various degradation products of organic chemicals present in the tanks. Volatile and semi-volatile organic chemicals in tanks also produce organic vapors. The generated gases in tank waste are either released continuously to the tank headspace or are retained in the waste matrix. Retained gas may be released in a spontaneous or induced gas release event (GRE) that can significantly increase the flammable gas concentration in the tank headspace as described in RPP-7771. The document categorizes each of the large waste storage tanks into one of several categories based on each tank's waste characteristics. These waste group assignments reflect a tank's propensity to retain a significant volume of flammable gases and the potential of the waste to release retained gas by a buoyant displacement event. Revision 5 is the annual update of the methodology and calculations of the flammable gas Waste Groups for DSTs and SSTs.

  14. METHODOLOGY & CALCULATIONS FOR THE ASSIGNMENT OF WASTE FOR THE LARGE UNDERGROUND WASTE STORAGE TANKS AT THE HANFORD SITE

    SciTech Connect (OSTI)

    TU, T.A.

    2007-01-04

    Waste stored within tank farm double-shell tanks (DST) and single-shell tanks (SST) generates flammable gas (principally hydrogen) to varying degrees depending on the type, amount, geometry, and condition of the waste. The waste generates hydrogen through the radiolysis of water and organic compounds, thermolytic decomposition of organic compounds, and corrosion of a tank's carbon steel walls. Radiolysis and thermolytic decomposition also generates ammonia. Nonflammable gases, which act as dilutents (such as nitrous oxide), are also produced. Additional flammable gases (e.g., methane) are generated by chemical reactions between various degradation products of organic chemicals present in the tanks. Volatile and semi-volatile organic chemicals in tanks also produce organic vapors. The generated gases in tank waste are either released continuously to the tank headspace or are retained in the waste matrix. Retained gas may be released in a spontaneous or induced gas release event (GRE) that can significantly increase the flammable gas concentration in the tank headspace as described in RPP-7771, Flammable Gas Safety Isme Resolution. Appendices A through I provide supporting information. The document categorizes each of the large waste storage tanks into one of several categories based on each tank's waste and characteristics. These waste group assignments reflect a tank's propensity to retain a significant volume of flammable gases and the potential of the waste to release retained gas by a buoyant displacement event. Revision 6 is the annual update of the flammable gas Waste Groups for DSTs and SSTs.

  15. 1H, 13C, and 15N backbone and side chain resonance assignments of thermophilic Geobacillus kaustophilus cyclophilin-A

    SciTech Connect (OSTI)

    Holliday, Michael; Zhang, Fengli; Isern, Nancy G.; Armstrong, Geoffrey S.; Eisenmesser, Elan Z.

    2014-04-01

    Cyclophilins catalyze the reversible peptidyl-prolyl isomerization of their substrates and are present across all kingdoms of life from humans to bacteria. Although numerous biological roles have now been discovered for cyclophilins, their function was initially ascribed to their chaperone-like activity in protein folding where they catalyze the often rate-limiting step of proline isomerization. This chaperone-like activity may be especially important under extreme conditions where cyclophilins are often over expressed, such as in tumors for human cyclophilins {Lee, 2010 #1167}, but also in organisms that thrive under extreme conditions, such as theromophilic bacteria. Moreover, the reversible nature of the peptidyl-prolyl isomerization reaction catalyzed by cyclophilins has allowed these enzymes to serve as model systems for probing the role of conformational changes during catalytic turnover {Eisenmesser, 2002 #20;Eisenmesser, 2005 #203}. Thus, we present here the resonance assignments of a thermophilic cyclophilin from Geobacillus kaustophilus derived from deep-sea sediment {Takami, 2004 #1384}. This thermophilic cyclophilin may now be studied at a variety of temperatures to provide insight into the comparative structure, dynamics, and catalytic mechanism of cyclophilins.

  16. U.S. Footage Drilled for Crude Oil Exploratory and Developmental Wells

    Gasoline and Diesel Fuel Update (EIA)

    (Thousand Feet) and Developmental Wells (Thousand Feet) U.S. Footage Drilled for Crude Oil Exploratory and Developmental Wells (Thousand Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 79,428 1950's 92,695 95,106 98,148 102,136 113,362 121,148 120,352 110,043 93,105 94,611 1960's 86,568 85,626 88,431 81,809 80,463 73,322 67,340 58,634 59,517 61,582 1970's 56,859 49,109 49,269 44,416 52,025 66,819 68,892 75,451 77,041 82,688 1980's 125,262 172,167

  17. U.S. Footage Drilled for Crude Oil, Natural Gas, and Dry Developmental

    Gasoline and Diesel Fuel Update (EIA)

    Wells (Thousand Feet) Developmental Wells (Thousand Feet) U.S. Footage Drilled for Crude Oil, Natural Gas, and Dry Developmental Wells (Thousand Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 100,821 1950's 117,183 122,802 128,518 133,581 148,408 156,976 158,943 147,864 131,820 137,441 1960's 136,345 135,191 141,018 129,164 131,923 125,678 107,215 93,518 94,012 99,642 1970's 95,026 85,358 92,875 92,605 102,059 125,817 133,365 157,917 173,472 181,702

  18. U.S. Footage Drilled for Dry Exploratory and Developmental Wells (Thousand

    Gasoline and Diesel Fuel Update (EIA)

    Feet) and Developmental Wells (Thousand Feet) U.S. Footage Drilled for Dry Exploratory and Developmental Wells (Thousand Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 43,754 1950's 50,977 63,093 70,730 73,862 75,790 85,103 90,190 83,167 74,643 79,476 1960's 77,361 74,716 77,253 76,307 81,360 76,629 69,636 61,142 64,737 71,364 1970's 58,074 54,685 58,556 55,761 62,899 69,220 68,977 76,728 85,788 81,642 1980's 99,575 134,934 123,746 105,222 119,860

  19. U.S. Footage Drilled for Natural Gas Exploratory and Developmental Wells

    Gasoline and Diesel Fuel Update (EIA)

    (Thousand Feet) and Developmental Wells (Thousand Feet) U.S. Footage Drilled for Natural Gas Exploratory and Developmental Wells (Thousand Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 12,437 1950's 13,685 13,947 15,257 18,248 18,857 19,930 22,738 23,836 25,555 26,606 1960's 28,246 29,292 28,949 24,533 25,598 24,931 25,948 21,581 20,716 24,162 1970's 23,623 23,460 30,006 38,045 38,449 44,454 49,113 63,686 75,841 80,468 1980's 92,106 108,353 107,149

  20. Taurine protects methamphetamine-induced developmental angiogenesis defect through antioxidant mechanism

    SciTech Connect (OSTI)

    Shao, Xue; Hu, Zhengtao; Hu, Chunyan; Bu, Qian; Yan, Guangyan; Deng, Pengchi; Lv, Lei; Wu, Dan; Deng, Yi; Zhao, Jinxuan; Zhu, Ruiming; Li, Yan; Li, Hongyu; Xu, Youzhi; Yang, Hanshuo; Zhao, Yinglan; Cen, Xiaobo

    2012-05-01

    Investigations have characterized addictive drug-induced developmental cardiovascular malformation in human, non-human primate and rodent. However, the underlying mechanism of malformation caused by drugs during pregnancy is still largely unknown, and preventive and therapeutic measures have been lacking. Using {sup 1}H NMR spectroscopy, we profiled the metabolites from human embryo endothelial cells exposed to methamphetamine (METH) and quantified a total of 226 peaks. We identified 11 metabolites modified robustly and found that taurine markedly increased. We then validated the hypothesis that this dramatic increase in taurine could attribute to its effect in inhibiting METH-induced developmental angiogenesis defect. Taurine supplement showed a more significant potential than other metabolites in protecting against METH-induced injury in endothelial cells. Taurine strongly attenuated METH-induced inhibition of proliferation and migration in endothelial cells. Furthermore, death rate and vessel abnormality of zebrafish embryos treated with METH were greatly reversed by taurine. In addition, taurine supplement caused a rapid decrease in reactive oxygen species generation and strongly attenuated the excitable arise of antioxidase activities in the beginning of METH exposure prophase. Dysregulations of NF-κB, p-ERK as well as Bax, which reflect apoptosis, cell cycle arrest and oxidative stress in vascular endothelium, were blocked by taurine. Our results provide the first evidence that taurine prevents METH-caused developmental angiogenesis defect through antioxidant mechanism. Taurine could serve as a potential therapeutic or preventive intervention of developmental vascular malformation for the pregnant women with drug use. Highlights: ► Metabonomics findings. ► Abnormal development. ► Dysregulations of key proteins.

  1. Nondestructive evaluation

    SciTech Connect (OSTI)

    Martz, H.E.

    1997-02-01

    Research reported in the thrust area of nondestructive evaluation includes: advanced 3-D imaging technologies; new techniques in laser ultrasonic testing; infrared computed tomography for thermal NDE of materials, structures, sources, and processes; automated defect detection for large laser optics; multistatic micropower impulse radar imaging for nondestructive evaluation; and multi-modal NDE for AVLIS pod shielding components.

  2. GALAXIES IN X-RAY GROUPS. I. ROBUST MEMBERSHIP ASSIGNMENT AND THE IMPACT OF GROUP ENVIRONMENTS ON QUENCHING

    SciTech Connect (OSTI)

    George, Matthew R.; Bundy, Kevin; Leauthaud, Alexie; Finoguenov, Alexis; Tinker, Jeremy; Lin, Yen-Ting; Mei, Simona; Kneib, Jean-Paul; Ilbert, Olivier; Aussel, Herve; Le Floc'h, Emeric; Behroozi, Peter S.; Busha, Michael T.; Capak, Peter; Coccato, Lodovico; Covone, Giovanni; Faure, Cecile; Fiorenza, Stephanie L.; and others

    2011-12-01

    Understanding the mechanisms that lead dense environments to host galaxies with redder colors, more spheroidal morphologies, and lower star formation rates than field populations remains an important problem. As most candidate processes ultimately depend on host halo mass, accurate characterizations of the local environment, ideally tied to halo mass estimates and spanning a range in halo mass and redshift, are needed. In this work, we present and test a rigorous, probabilistic method for assigning galaxies to groups based on precise photometric redshifts and X-ray-selected groups drawn from the COSMOS field. The groups have masses in the range 10{sup 13} {approx}< M{sub 200c}/M{sub Sun} {approx}< 10{sup 14} and span redshifts 0 < z < 1. We characterize our selection algorithm via tests on spectroscopic subsamples, including new data obtained at the Very Large Telescope, and by applying our method to detailed mock catalogs. We find that our group member galaxy sample has a purity of 84% and completeness of 92% within 0.5 R{sub 200c}. We measure the impact of uncertainties in redshifts and group centering on the quality of the member selection with simulations based on current data as well as future imaging and spectroscopic surveys. As a first application of our new group member catalog which will be made publicly available, we show that member galaxies exhibit a higher quenched fraction compared to the field at fixed stellar mass out to z {approx} 1, indicating a significant relationship between star formation and environment at group scales. We also address the suggestion that dusty star-forming galaxies in such groups may impact the high-l power spectrum of the cosmic microwave background and find that such a population cannot explain the low power seen in recent Sunyaev-Zel'dovich measurements.

  3. Advancing Usability Evaluation through Human Reliability Analysis

    SciTech Connect (OSTI)

    Ronald L. Boring; David I. Gertman

    2005-07-01

    This paper introduces a novel augmentation to the current heuristic usability evaluation methodology. The SPAR-H human reliability analysis method was developed for categorizing human performance in nuclear power plants. Despite the specialized use of SPAR-H for safety critical scenarios, the method also holds promise for use in commercial off-the-shelf software usability evaluations. The SPAR-H method shares task analysis underpinnings with human-computer interaction, and it can be easily adapted to incorporate usability heuristics as performance shaping factors. By assigning probabilistic modifiers to heuristics, it is possible to arrive at the usability error probability (UEP). This UEP is not a literal probability of error but nonetheless provides a quantitative basis to heuristic evaluation. When combined with a consequence matrix for usability errors, this method affords ready prioritization of usability issues.

  4. SEPA Reallocation

    Office of Environmental Management (EM)

    Department of Energy SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Form documents modifications and changes to approved assignments and courses. SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) (100.74 KB) More Documents & Publications SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT PROGRAM (SESCDP) Candidate Developmental Assignment Evaluation SENIOR EXECUTIVE SERVICE CANDIDATE DEVELOPMENT

  5. The high current, fast, 100ns, Linear Transformer Driver (LTD) developmental project at Sandia Laboratories and HCEI.

    SciTech Connect (OSTI)

    Ward, Kevin S.; Long, Finis W.; Sinebryukhov, Vadim A. , Tomsk, Russia); Kim, Alexandre A. , Tomsk, Russia); Wakeland, Peter Eric; McKee, G. Randall; Woodworth, Joseph Ray; McDaniel, Dillon Heirman; Fowler, William E.; Mazarakis, Michael Gerrassimos; Porter, John Larry, Jr.; Struve, Kenneth William; Savage, Mark Edward; Stygar, William A.; LeChien, Keith R.; Matzen, Maurice Keith

    2010-09-01

    Sandia National Laboratories, Albuquerque, N.M., USA, in collaboration with the High Current Electronic Institute (HCEI), Tomsk, Russia, is developing a new paradigm in pulsed power technology: the Linear Transformer Driver (LTD) technology. This technological approach can provide very compact devices that can deliver very fast high current and high voltage pulses straight out of the cavity with out any complicated pulse forming and pulse compression network. Through multistage inductively insulated voltage adders, the output pulse, increased in voltage amplitude, can be applied directly to the load. The load may be a vacuum electron diode, a z-pinch wire array, a gas puff, a liner, an isentropic compression load (ICE) to study material behavior under very high magnetic fields, or a fusion energy (IFE) target. This is because the output pulse rise time and width can be easily tailored to the specific application needs. In this paper we briefly summarize the developmental work done in Sandia and HCEI during the last few years, and describe our new MYKONOS Sandia High Current LTD Laboratory. An extensive evaluation of the LTD technology is being performed at SNL and the High Current Electronic Institute (HCEI) in Tomsk Russia. Two types of High Current LTD cavities (LTD I-II, and 1-MA LTD) were constructed and tested individually and in a voltage adder configuration (1-MA cavity only). All cavities performed remarkably well and the experimental results are in full agreement with analytical and numerical calculation predictions. A two-cavity voltage adder is been assembled and currently undergoes evaluation. This is the first step towards the completion of the 10-cavity, 1-TW module. This MYKONOS voltage adder will be the first ever IVA built with a transmission line insulated with deionized water. The LTD II cavity renamed LTD III will serve as a test bed for evaluating a number of different types of switches, resistors, alternative capacitor configurations, cores

  6. Relative risk site evaluations for Yakima Training Center

    SciTech Connect (OSTI)

    Smith, R.M.; Whelan, G.

    1996-11-01

    All 20 U.S. Army Yakima Training Center (YTC) sites evaluated were given a `low` relative risk. At Solid Waste Management Unit (SWMU) 22, a `minimum` soils contaminant hazard factor was assigned even though 6,700 mg/kg TPH-diesel was found in surface soil. SWMU 22 is physically located on top of and with the fence surrounding Area of Concern (AOC) 4. Because the diesel is most likely associated with AOC 4, and plans are to clean up AOC 4, any further actions regarding these contaminated soils should be addressed as part of the planned actions for AOC 4. Contaminant hazard factors of `moderate` were assigned to the soil pathway for SWMUs 4 and 7 because dieldrin and arsenic, respectively, were found in surface soil samples at concentrations exceeding standards. A `moderate` contaminant hazard factor was also assigned to the sediment pathway for AOC 1 because arsenic detected in sediments in `Larry`s Swimming Pool` exceeded the standard. All other contaminant hazard factors were rated as minimal. The receptor factor for all sites and pathways was rated `limited,` except for SWMU 54 in which the groundwater receptor factor was rated `potential.` A `potential` rating was assigned to the groundwater pathway at this site to be conservative. The site is located on the south side of the syncline axis where the unconfined aquifer may be present and there are no monitoring wells at the site to confirm or deny the presence of groundwater contamination.

  7. Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Goodale, B. C.; Geisel School of Medicine at Dartmouth, Hanover, NH; La Du, J.; Tilton, S. C.; Pacific Northwest National Lab.; Sullivan, C. M.; Bisson, W. H.; Waters, K. M.; Tanguay, R. L.

    2015-07-03

    Polycyclic aromatic hydrocarbons (PAHs) are priority environmental contaminants that exhibit mutagenic, carcinogenic, proinflammatory, and teratogenic properties. Oxygen-substituted PAHs (OPAHs) are formed during combustion processes and via phototoxidation and biological degradation of parent (unsubstituted) PAHs. Despite their prevalence both in contaminated industrial sites and in urban air, OPAH mechanisms of action in biological systems are relatively understudied. Like parent PAHs, OPAHs exert structure-dependent mutagenic activities and activation of the aryl hydrocarbon receptor (AHR) and cytochrome p450 metabolic pathway. Four-ring OPAHs 1,9-benz-10-anthrone (BEZO) and benz(a)anthracene-7,12-dione (7,12-B[a]AQ) cause morphological aberrations and induce markers of oxidative stress in developing zebrafish with similar potency, butmore » only 7,12-B[a]AQ induces robust Cyp1a protein expression. We investigated the role of the AHR in mediating the toxicity of BEZO and 7,12-B[a]AQ, and found that knockdown of AHR2 rescued developmental effects caused by both compounds. Using RNA-seq and molecular docking, we identified transcriptional responses that precede developmental toxicity induced via differential interaction with AHR2. Redox-homeostasis genes were affected similarly by these OPAHs, while 7,12-B[a]AQ preferentially activated phase 1 metabolism and BEZO uniquely decreased visual system genes. Analysis of biological functions and upstream regulators suggests that BEZO is a weak AHR agonist, but interacts with other transcriptional regulators to cause developmental toxicity in an AHR-dependent manner. Furthermore, identifying ligand-dependent AHR interactions and signaling pathways is essential for understanding toxicity of this class of environmentally relevant compounds.« less

  8. Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs

    SciTech Connect (OSTI)

    Goodale, B. C.; La Du, J.; Tilton, S. C.; Sullivan, C. M.; Bisson, W. H.; Waters, K. M.; Tanguay, R. L.

    2015-07-03

    Polycyclic aromatic hydrocarbons (PAHs) are priority environmental contaminants that exhibit mutagenic, carcinogenic, proinflammatory, and teratogenic properties. Oxygen-substituted PAHs (OPAHs) are formed during combustion processes and via phototoxidation and biological degradation of parent (unsubstituted) PAHs. Despite their prevalence both in contaminated industrial sites and in urban air, OPAH mechanisms of action in biological systems are relatively understudied. Like parent PAHs, OPAHs exert structure-dependent mutagenic activities and activation of the aryl hydrocarbon receptor (AHR) and cytochrome p450 metabolic pathway. Four-ring OPAHs 1,9-benz-10-anthrone (BEZO) and benz(a)anthracene-7,12-dione (7,12-B[a]AQ) cause morphological aberrations and induce markers of oxidative stress in developing zebrafish with similar potency, but only 7,12-B[a]AQ induces robust Cyp1a protein expression. We investigated the role of the AHR in mediating the toxicity of BEZO and 7,12-B[a]AQ, and found that knockdown of AHR2 rescued developmental effects caused by both compounds. Using RNA-seq and molecular docking, we identified transcriptional responses that precede developmental toxicity induced via differential interaction with AHR2. Redox-homeostasis genes were affected similarly by these OPAHs, while 7,12-B[a]AQ preferentially activated phase 1 metabolism and BEZO uniquely decreased visual system genes. Analysis of biological functions and upstream regulators suggests that BEZO is a weak AHR agonist, but interacts with other transcriptional regulators to cause developmental toxicity in an AHR-dependent manner. Furthermore, identifying ligand-dependent AHR interactions and signaling pathways is essential for understanding toxicity of this class of environmentally relevant compounds.

  9. Eliminating livelock by assigning the same priority state to each message that is inputted into a flushable routing system during N time intervals

    DOE Patents [OSTI]

    Faber, Vance

    1994-01-01

    Livelock-free message routing is provided in a network of interconnected nodes that is flushable in time T. An input message processor generates sequences of at least N time intervals, each of duration T. An input register provides for receiving and holding each input message, where the message is assigned a priority state p during an nth one of the N time intervals. At each of the network nodes a message processor reads the assigned priority state and awards priority to messages with priority state (p-1) during an nth time interval and to messages with priority state p during an (n+1) th time interval. The messages that are awarded priority are output on an output path toward the addressed output message processor. Thus, no message remains in the network for a time longer than T.

  10. Eliminating livelock by assigning the same priority state to each message that is input into a flushable routing system during N time intervals

    DOE Patents [OSTI]

    Faber, V.

    1994-11-29

    Livelock-free message routing is provided in a network of interconnected nodes that is flushable in time T. An input message processor generates sequences of at least N time intervals, each of duration T. An input register provides for receiving and holding each input message, where the message is assigned a priority state p during an nth one of the N time intervals. At each of the network nodes a message processor reads the assigned priority state and awards priority to messages with priority state (p-1) during an nth time interval and to messages with priority state p during an (n+1) th time interval. The messages that are awarded priority are output on an output path toward the addressed output message processor. Thus, no message remains in the network for a time longer than T. 4 figures.

  11. RELAP5/MOD2 Overview and Developmental. Assessment Results from TMl-1 Plant Transient Analysis

    SciTech Connect (OSTI)

    Lin, J. C.; Tsai, C. C.; Ransom, V. H.; Johnsen, G. W.

    2013-02-01

    RELAP5/MOD2 is a new version of the RELAP5 thermal-hydraulic computer code containing improved modeling features that provide a generic capability for pressurized water reactor transient simulation. The objective of this paper is to provide code users with an overview of the code and to report developmental assessment results obtained from a Three Mile Island Unit One plant transient analysis. The assessment shows that the injection of highly sub-cooled water into a high-pressure primary coolant system does not cause unphysical results or pose a problem for RELAP5/MOD2. (author)

  12. RELAP5/MOD2 overview and developmental assessment results from TMI-1 plant transient analysis

    SciTech Connect (OSTI)

    Lin, J.C.; Tsai, C.C.; Ransom, V.H.; Johnsen, G.W.

    1984-01-01

    RELAP5/MOD2 is a new version of the RELAP5 thermal-hydraulic computer code containing improved modeling features that provide a generic capability for pressurized water reactor transient simulation. Objective of this paper is to provide code users with an overview of the code and to report developmental assessment results obtained from a Three Mile Island Unit One plant transient analysis. The assessment shows that the injection of highly subcooled water into a high-pressure primary coolant system does not cause unphysical results or pose a problem for RELAP5/MOD2.

  13. Recent experimental results from a long-pulse J-band relativistic klystron amplifier developmental effort

    SciTech Connect (OSTI)

    Kato, K.G.; Crouch, D.D.; Sar, D.R.; Speciale, R.A.; Carlsten, B.E.; Fazio, M.V.; Haynes, W.B.; Stringfield, R.M.

    1994-12-31

    Recent experimental results, supporting simulations, and design modeling are presented from a developmental effort to a produce a long pulse ({approximately}1{mu}s) J-band (5.85-8.2 GHz) relativistic klystron amplifier (RKA) of the high current NRL genealogy. This RKA is designed to operate at approximately 6.6 GHz, with a desired RF output {approximately}700 MW. Conversion of electron beam energy to microwave energy is obtained by a mock magnetically insulated coaxial converter which, in various incarnations, can be made to be either a cavity gap extractor or an inverse cathode.

  14. Sub-microradian Surface Slope Metrology with the ALS Developmental Long Trace Profiler

    SciTech Connect (OSTI)

    Yashchuk, Valeriy V; Barber, Samuel; Domning, Edward E.; Kirschman, Jonathan L.; Morrison, Gregory Y.; Smith, Brian V; Siewert, Frank; Zeschke, Thomas; Geckeler, Ralf; Just, Andreas

    2009-09-11

    A new low budget slope measuring instrument, the Developmental Long Trace Profiler (DLTP), was recently brought to operation at the ALS Optical Metrology Laboratory. The design, instrumental control and data acquisition system, initial alignment and calibration procedures, as well as the developed experimental precautions and procedures are described in detail. The capability of the DLTP to achieve sub-microradian surface slope metrology is verified via cross-comparison measurements with other high performance slope measuring instruments when measuring the same high quality test optics. The directions of future work to develop a surface slope measuring profiler with nano-radian performance are also discussed.

  15. Inhalation developmental toxicology studies: Teratology study of tetrahydrofuran in mice and rats: Final report

    SciTech Connect (OSTI)

    Mast, T.J.; Evanoff, J.J.; Stoney, K.H.; Westerberg, R.B.; Rommereim, R.L.; Weigel, R.J.

    1988-08-01

    Tetrahydrofuran (THF), a four-carbon cyclic ether, is widely used as an industrial solvent. Although it has been used in large quantities for many years, few long-term toxicology studies, and no reproductive or developmental studies, have been conducted on THF. This study addresses the potential for THF to cause developmental toxicity in rodents by exposing Sprague-Dawley rats and Swiss (CD-1) mice to 0, 600, 1800, or 5000 ppm tetrahydrofuran (THF) vapors, 6 h/day, 7 dy/wk. Each treatment group consisted of 10 virgin females (for comparison), and approx.33 positively mated rats or mice. Positively mated mice were exposed on days 6--17 of gestation (dg), and rats on 6--19 dg. The day of plug or sperm detection was designated as O dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded and live fetuses were examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 27 refs., 6 figs., 23 tabs.

  16. U.S. Average Depth of Crude Oil Exploratory and Developmental Wells Drilled

    Gasoline and Diesel Fuel Update (EIA)

    (Feet per Well) and Developmental Wells Drilled (Feet per Well) U.S. Average Depth of Crude Oil Exploratory and Developmental Wells Drilled (Feet per Well) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 3,720 1950's 3,893 4,103 4,214 4,033 4,028 3,981 3,942 4,021 3,916 3,935 1960's 3,889 3,994 4,070 4,063 4,042 4,059 4,013 3,825 4,153 4,286 1970's 4,385 4,126 4,330 4,369 3,812 3,943 3,895 4,025 4,017 3,966 1980's 3,801 3,923 3,793 3,662 3,791 3,906 3,999

  17. U.S. Average Depth of Crude Oil, Natural Gas, and Dry Developmental Wells

    Gasoline and Diesel Fuel Update (EIA)

    Drilled (Feet per Well) Developmental Wells Drilled (Feet per Well) U.S. Average Depth of Crude Oil, Natural Gas, and Dry Developmental Wells Drilled (Feet per Well) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 3,568 1950's 3,691 3,851 3,999 3,880 3,905 3,904 3,880 3,966 3,907 3,999 1960's 4,020 4,064 4,227 4,193 4,179 4,288 4,112 4,004 4,328 4,431 1970's 4,610 4,480 4,590 4,687 4,249 4,285 4,214 4,404 4,421 4,374 1980's 4,166 4,209 4,225 4,004 4,125

  18. U.S. Average Depth of Dry Exploratory and Developmental Wells Drilled (Feet

    Gasoline and Diesel Fuel Update (EIA)

    per Well) Exploratory and Developmental Wells Drilled (Feet per Well) U.S. Average Depth of Dry Exploratory and Developmental Wells Drilled (Feet per Well) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 3,473 1950's 3,445 3,706 3,983 4,004 4,004 4,161 4,079 4,126 4,110 4,275 1960's 4,248 4,311 4,524 4,552 4,598 4,723 4,573 4,616 5,053 5,195 1970's 5,265 5,305 5,377 5,403 5,191 5,073 5,014 5,120 5,183 5,071 1980's 4,791 4,827 4,691 4,320 4,631 4,733 4,763

  19. U.S. Average Depth of Dry Holes Developmental Wells Drilled (Feet per Well)

    Gasoline and Diesel Fuel Update (EIA)

    Developmental Wells Drilled (Feet per Well) U.S. Average Depth of Dry Holes Developmental Wells Drilled (Feet per Well) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 3,225 1950's 3,077 3,255 3,520 3,401 3,512 3,699 3,574 3,605 3,631 3,844 1960's 3,889 3,782 4,239 4,143 4,207 4,446 3,900 3,901 4,311 4,437 1970's 4,714 4,633 4,725 4,851 4,599 4,415 4,439 4,662 4,600 4,517 1980's 4,214 4,226 4,184 3,974 4,205 4,306 4,236 4,390 4,704 4,684 1990's 4,755 4,629

  20. U.S. Average Depth of Natural Gas Developmental Wells Drilled (Feet per

    Gasoline and Diesel Fuel Update (EIA)

    Well) Developmental Wells Drilled (Feet per Well) U.S. Average Depth of Natural Gas Developmental Wells Drilled (Feet per Well) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 3,412 1950's 3,766 3,837 4,015 4,373 4,365 4,339 4,734 4,950 4,801 5,120 1960's 5,321 5,145 5,186 5,198 5,171 5,337 5,474 5,629 5,716 5,531 1970's 5,644 5,670 5,259 5,286 5,173 5,238 4,960 5,053 5,066 5,082 1980's 5,093 5,149 5,453 5,187 5,158 5,193 5,080 5,112 5,155 5,038 1990's

  1. U.S. Average Depth of Natural Gas Exploratory and Developmental Wells

    Gasoline and Diesel Fuel Update (EIA)

    Drilled (Feet per Well) and Developmental Wells Drilled (Feet per Well) U.S. Average Depth of Natural Gas Exploratory and Developmental Wells Drilled (Feet per Well) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 3,698 1950's 3,979 4,056 4,342 4,599 4,670 4,672 5,018 5,326 5,106 5,396 1960's 5,486 5,339 5,408 5,368 5,453 5,562 5,928 5,898 5,994 5,918 1970's 5,860 5,890 5,516 5,488 5,387 5,470 5,220 5,254 5,262 5,275 1980's 5,275 5,351 5,617 5,319 5,276

  2. U.S. Footage Drilled for Dry Developmental Wells (Thousand Feet)

    Gasoline and Diesel Fuel Update (EIA)

    Developmental Wells (Thousand Feet) U.S. Footage Drilled for Dry Developmental Wells (Thousand Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 17,315 1950's 20,020 24,370 26,999 26,582 29,998 31,883 32,143 29,747 27,343 30,800 1960's 33,826 31,423 35,030 33,460 36,782 36,548 26,552 22,960 23,162 25,446 1970's 22,951 20,186 22,475 21,190 24,296 28,772 31,008 35,905 39,493 39,130 1980's 49,326 65,720 63,066 56,233 61,236 52,784 30,636 26,842 25,438 20,152

  3. U.S. Footage Drilled for Natural Gas Developmental Wells (Thousand Feet)

    Gasoline and Diesel Fuel Update (EIA)

    Developmental Wells (Thousand Feet) U.S. Footage Drilled for Natural Gas Developmental Wells (Thousand Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1940's 10,028 1950's 11,329 11,451 11,863 14,296 14,458 14,718 17,559 17,869 20,083 20,575 1960's 22,780 24,042 23,762 20,303 21,394 21,174 20,140 17,602 16,975 19,177 1970's 19,945 19,850 25,159 31,007 30,766 36,032 39,992 53,431 64,043 67,825 1980's 78,244 91,274 92,386 67,844 81,545 68,149 39,638 37,520 40,371

  4. American Evaluation Association Guiding Principles for Evaluators...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles ...

  5. Gene expression profiles in the cerebellum and hippocampus following exposure to a neurotoxicant, Aroclor 1254: Developmental effects

    SciTech Connect (OSTI)

    Royland, Joyce E.; Wu, Jinfang; Zawia, Nasser H.; Kodavanti, Prasada Rao S.

    2008-09-01

    The developmental consequences of exposure to the polychlorinated biphenyls (PCBs) have been widely studied, making PCBs a unique model to understand issues related to environmental mixture of persistent chemicals. PCB exposure in humans adversely affects neurocognitive development, causes psychomotor difficulties, and contributes to attention deficits in children, all of which seem to be associated with altered patterns of neuronal connectivity. In the present study, we examined gene expression profiles in the rat nervous system following PCB developmental exposure. Pregnant rats (Long-Evans) were dosed perinatally with 0 or 6 mg/kg/day of Aroclor 1254 from gestation day 6 through postnatal day (PND) 21. Gene expression in cerebellum and hippocampus from PND7 and PND14 animals was analyzed with an emphasis on developmental aspects. Changes in gene expression ({>=} 1.5 fold) in control animals identified normal developmental changes. These basal levels of expression were compared to data from Aroclor 1254-treated animals to determine the impact of gestational PCB exposure on developmental parameters. The results indicate that the expression of a number of developmental genes related to cell cycle, synaptic function, cell maintenance, and neurogenesis is significantly altered from PND7 to PND14. Aroclor 1254 treatment appears to dampen the overall growth-related gene expression levels in both regions with the effect being more pronounced in the cerebellum. Functional analysis suggests that Aroclor 1254 delays maturation of the developing nervous system, with the consequences dependent on the ontological state of the brain area and the functional role of the individual gene. Such changes may underlie learning and memory deficits observed in PCB exposed animals and humans.

  6. American Evaluation Association Guiding Principles for Evaluators

    SciTech Connect (OSTI)

    None

    2009-01-18

    Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles they can expect to be upheld by professional evaluators.

  7. Final report on the developmental toxicity of ethylenediamine (CAS No. 107-15-3) in New Zealand white rabbits. Report for November-February 1992

    SciTech Connect (OSTI)

    Not Available

    1993-03-01

    Ethylenediamine (EDA) is a major industrial chemical with an estimated U.S. production of 64 million pounds in 1985. EDA is used as a chemical intermediate or solvent in manufacturing, as a paint thinner, and as a constituent of certain cosmetic, pharmaceutical and veterinary products. Based upon its widespread applications and the potential for exposure in pregnant women, EDA was evaluated for maternal and developmental toxicity using a laboratory animal model. Artificially-inseminated New Zealand White rabbits (26/group) were administered ethylenediamine (0, 10, 40 or 80 mg/kg/day) by gavage on gestational days (gd) 6 through 19. The doses administered were equivalent to 0, 22, 89 or 178 of EDA.2HC1. Maternal clinical signs, body weight, and food consumption were monitored at regular intervals throughout gestation. At termination (gd 30), the uterus was removed and examined to determine pregnancy status and to evaluate the number of resorptions, and dead or live fetuses. Dead or live fetuses were weighed, and live fetuses examined for external, visceral and skeletal defects.

  8. Mineral evaluation of part of the Gold Butte district, Clark County, Nevada. National Uranium Resource Evaluation

    SciTech Connect (OSTI)

    Dexter, J.J.; Goodknight, C.S.; Dayvault, R.D.; Dickson, R.E.

    1983-03-01

    The mineral potential of part of the Gold Butte district, Clark County, Nevada, was investigated to supplement the evaluation of granitic rocks in the area as a probable geologic environment for uranium mineralization. This project is a part of the National Uranium Resource Evaluation (NURE) program conducted by Bendix Field Engineering Corporation for the US Department of Energy. A total of 41 stream-sediment samples and 149 rock samples were collected; the stream-sediment samples were analyzed chemically, and most f the rock samples were analyzed chemically and petrographically. The project area was restricted to Precambrian rocks, which comprise a metamorphic complex of early Proterozoic age, charnockitic rocks of early or middle Proterozoic age and ultramafic rocks and the Gold Butte Granite of middle Proterozoic age. Although the project area is not favorable for uranium deposits according to NURE criteria, an area of low resource potential for uranium, thorium, rare-earth elements and yttrium, and niobium-tantalum was assigned to the contact zone of the Gold Butte Granite. Pegmatites and aplites in the zone contain high concentrations of these elements. Two areas of moderate potential for gold and silver in quartz veins are within the project area; small-scale operations may recover these elements profitably. Titanium has a low-to-moderate resource potential, although the deposits are currently subeconomic. The titanium concentrations occur as titaniferous magnetite- and ilmenite-bearing placer sands. One small area has been assigned a low-to-moderate resource potential for vermiculite in altered ultramafic rocks. Tungsten has been assigned a low resource potential in two places within the project area; scheelite-bearing ultramafic bodies are small and scattered. Platinum-group metals and copper have no resource potential in the project area.

  9. Operation Greenhouse. Scientific Director's report of atomic weapon tests at Eniwetok, 1951. Annex 6. 6. Evaluation of filter material

    SciTech Connect (OSTI)

    Engquist, E,H.

    1985-04-01

    Four types of standard and developmental filter materials used in individual and collective-protective devices and one type of developmental filter material used for sampling of air for particulate matter were evaluated against the contamination produced by the detonation of an atomic bomb and present in the resulting radioactive cloud. These filter materials were evaluated in multilayer pads at the standard flow-rate conditions used by the Chemical Corps in evaluation studies of filter materials. This permitted correlation of results of laboratory data. Analysis of the materials was made by counting the gross beta activity collected on successive layers of the same filter material and the efficiency of the materials was calculated from the data obtained.

  10. Full differentiation and assignment of boron species in the electrolytes Li{sub 2}B{sub 6}O{sub 9}F{sub 2} and Li{sub 2}B{sub 3}O{sub 4}F{sub 3} by solid-state {sup 11}B NMR spectroscopy

    SciTech Connect (OSTI)

    Braeuniger, Thomas; Pilz, Thomas; Chandran, C. Vinod; Jansen, Martin

    2012-10-15

    The syntheses of two new fluorooxoborates, Li{sub 2}B{sub 3}O{sub 4}F{sub 3} and Li{sub 2}B{sub 6}O{sub 9}F{sub 2}, which possess considerable ion conductivity at higher temperatures, have been reported recently. Here, we describe the characterisation of these compounds by solid-state {sup 11}B NMR spectroscopy. The complex central-transition MAS spectra, resulting from overlap of sub-spectra contributed by the individual boron species in the crystal structures, could be clearly separated by acquisition and analysis of 3QMAS spectra. By numerical fit of these sub-spectra, the isotropic chemical shift {delta}{sub iso}, the quadrupolar coupling constant {chi}, and the asymmetry {eta} were determined. Using known relations between boron coordination and chemical shift as well as quadrupolar coupling, the individual {sup 11}B NMR resonances have been ascribed to boron species in tetrahedral or trigonal environment. To remove remaining assignment ambiguities, the response of the {sup 11}B resonances to {sup 19}F decoupling was qualitatively analysed. Thus, by using the combined information conveyed by chemical shift, quadrupolar and dipolar interaction, a complete assignment of the complex {sup 11}B line shapes exhibited by the fluorooxoborates has been achieved. - Graphical abstract: Structure and solid-state {sup 11}B NMR spectrum of Li{sub 2}B{sub 3}O{sub 4}F{sub 3}. Highlights: Black-Right-Pointing-Pointer Characterisation of title compounds by solid-state {sup 11}B NMR spectroscopy. Black-Right-Pointing-Pointer Sub-spectra of boron species separated by evaluation of 3QMAS spectra. Black-Right-Pointing-Pointer Isotropic chemical shift and quadrupolar interaction parameters determined. Black-Right-Pointing-Pointer Full boron assignment based on NMR parameters and response to {sup 19}F decoupling.

  11. RTAP evaluation

    SciTech Connect (OSTI)

    Cupps, K.; Elko, S.; Folta, P.

    1995-01-23

    An in-depth analysis of the RTAP product was undertaken within the CNC associate program to determine the feasibility of utilizing it to replace the current Supervisory Control System that supports the AVLIS program. This document contains the results of that evaluation. With some fundamental redesign the current Supervisory Control system could meet the needs described above. The redesign would require a large amount of software rewriting and would be very time consuming. The higher level functionality (alarming, automation, etc.) would have to wait until its completion. Our current understanding and preliminary testing indicate that using commercial software is the best way to get these new features at the minimum cost to the program. Additional savings will be obtained by moving the maintenance costs of the basic control system from in-house to commercial industry and allowing our developers to concentrate on the unique control areas that require customization. Our current operating system, VMS, has become a hindrance. The UNIX operating system has become the choice for most scientific and engineering systems and we should follow suit. As a result of the commercial system survey referenced above we selected RTAP, a SCADA product developed by Hewlett Packard (HP), as the most favorable product to replace the current supervisory system in AVLIS. It is an extremely open system, with a large, well defined Application Programming Interface (API). This will allow the seamless integration of unique front end devices in the laser area (e.g. Optical Device Controller). RTAP also possesses various functionality that is lacking in our current system: integrated alarming, real-time configurable database, system scalability, and a Sequence Control Language (SQL developed by CPU, an RTAP Channel Partner) that will facilitate the automation necessary to bring the AVLIS process to plant-line operation. It runs on HP-9000, DEC-Alpha, IBM-RS6000 and Sun Workstations.

  12. A developmentally plastic adult mouse kidney cell line spontaneously generates multiple adult kidney structures

    SciTech Connect (OSTI)

    Webb, Carol F.; Ratliff, Michelle L.; Powell, Rebecca; Wirsig-Wiechmann, Celeste R.; Lakiza, Olga; Obara, Tomoko

    2015-08-07

    Despite exciting new possibilities for regenerative therapy posed by the ability to induce pluripotent stem cells, recapitulation of three-dimensional kidneys for repair or replacement has not been possible. ARID3a-deficient mouse tissues generated multipotent, developmentally plastic cells. Therefore, we assessed the adult mouse ARID3a−/− kidney cell line, KKPS5, which expresses renal progenitor surface markers as an alternative cell source for modeling kidney development. Remarkably, these cells spontaneously developed into multicellular nephron-like structures in vitro, and engrafted into immunocompromised medaka mesonephros, where they formed mouse nephron structures. These data implicate KKPS5 cells as a new model system for studying kidney development. - Highlights: • An ARID3a-deficient mouse kidney cell line expresses multiple progenitor markers. • This cell line spontaneously forms multiple nephron-like structures in vitro. • This cell line formed mouse kidney structures in immunocompromised medaka fish kidneys. • Our data identify a novel model system for studying kidney development.

  13. Inhalation developmental toxicology studies: Teratology study of acetone in mice and rats: Final report

    SciTech Connect (OSTI)

    Mast, T.J.; Evanoff, J.J.; Rommereim, R.L.; Stoney, K.H.; Weigel, R.J.; Westerberg, R.B.

    1988-11-01

    Acetone, an aliphatic ketone, is a ubiquitous industrial solvent and chemical intermediate; consequently, the opportunity for human exposure is high. The potential for acetone to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 440, 2200, or 11000 ppm, and in Swiss (CD-1) mice exposed to 0, 440, 2200, and 6600 ppm acetone vapors, 6 h/day, 7 days/week. Each of the four treatment groups consisted of 10 virgin females (for comparison), and approx.32 positively mated rats or mice. Positively mated mice were exposed on days 6-17 of gestation (dg), and rats on 6-19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 46 refs., 6 figs., 27 tabs.

  14. Inhalation developmental toxicology studies: Teratology study of isoprene in mice and rats: Final report

    SciTech Connect (OSTI)

    Mast, T.J.; Evanoff, J.J.; Stoney, K.H.; Westerberg, R.B.; Rommereim, R.L.; Weigel, R.J.

    1989-01-01

    Isoprene, a reactive, branched diene, is used in large quantities in the manufacture of polyisoprene and as a copolymer in the synthesis of butyl rubber. The potential for isoprene to cause developmental toxicity was assessed in rodents, by exposing four groups each of Sprague-Dawley rats and Swiss (CD-1) mice to 0, 280, 1400, or 7000 ppM isoprene vapors, 6 h/day, 7 day/wk. Each treatment group consisted of 10 virgin females (for comparison), and approx.30 positively mated rats or mice. Positively mated mice were exposed on days 6-17 of gestation (dg), and rats on 6-19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 31 refs., 6 figs., 19 tabs.

  15. Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells

    SciTech Connect (OSTI)

    Dartel, Dorien A.M. van; Pennings, Jeroen L.A.; Schooten, Frederik J. van; Piersma, Aldert H.

    2010-03-15

    The embryonic stem cell test (EST) predicts developmental toxicity based on the inhibition of cardiomyocyte differentiation of embryonic stem cells (ESC). The subjective endpoint, the long culture duration together with the undefined applicability domain and related predictivity need further improvement to facilitate implementation of the EST into regulatory strategies. These aspects may be improved by studying gene expression changes in the ESC differentiation cultures and their modulation by compound exposure using transcriptomics. Here, we tested the developmental toxicants monobutyl phthalate and 6-aminonicotinamide. ESC were allowed to differentiated, and cardiomyocyte differentiation was assessed after 10 days of culture. RNA of solvent controls was collected after 0, 24, 48, 72 and 96 h of exposure, and RNA of developmental-toxicant-exposed cultures was collected after 24 and 96 h. Samples were hybridized to DNA microarrays, and 1355 genes were found differentially expressed among the unexposed experimental groups. These regulated genes were involved in differentiation-related processes, and Principal Component Analysis (PCA) based on these genes showed that the unexposed experimental groups appeared in chronological order in the PCA, which can therefore be regarded as a continuous representation of the differentiation track. The developmental-toxicant-exposed cultures appeared to deviate significantly from this differentiation track, which confirms the compound-modulating effects on the differentiation process. The incorporation of transcriptomics in the EST is expected to provide a more informative and improved endpoint in the EST as compared with morphology, allowing early detection of differentiation modulation. Furthermore, this approach may improve the definition of the applicability domain and predictivity of the EST.

  16. Overseas Assignments | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    This handbook covers all types of Federal employment overseas, including details, both within DOE as well as to other agencies; transfers to approved international organizations; ...

  17. JOBAID-ASSIGNING DELEGATES (SUPERVISOR)

    Broader source: Energy.gov [DOE]

    The purpose of this job aid is to guide you through the step-by-step process of isung the delegate feature within SuccessFactors Learning.

  18. Program Assignments | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Balanced Scorecard Program Officer Contractual Services Budget Officer Headquarters Purchase Card Program Headquarters Contract Closeout Headquarters Data Mining Programs Strategic ...

  19. Metallurgical evaluation of FMPC Vessel No. 2

    SciTech Connect (OSTI)

    Bagnall, C.; Wise, W.N.

    1989-03-01

    A major purpose of this evaluation program was to accumulate information on the behavior and properties of a vessel at the Feed Materials Production Center, fabricated of Monel 400, after service exposure in a UF/sub 6/--UF/sub 4/ reduction tower. These data will then be used to aid in the formulation of an equation to predict remaining life for the vessels. In addition, data from this destructive evaluation will provide information on the reliability of the reaction vessel surveillance program currently in operation at FMPC. After 1400 h of operation, Vessel No. 2 was removed from service and assigned to this program for extensive study. The report describes an initial survey of the physical condition of the vessel, provides details of the sampling plan, and then proceeds to document information in the various areas of investigation. These include radiography, chemical analysis, and mechanical properties over a temperature range up to 1800/degree/F. Metallographic studies from six key locations of the reaction vessel were conducted; major weld areas and selected tensile specimens were also examined. The report continues with a summary of the findings and a discussion of key aspects in relation to pertinent literature. The final section of the report provides conclusions drawn from evaluation of Vessel No. 2, and sets forth recommendations related to fabrication and extension of its operating life. 12 refs., 43 figs., 16 tabs.

  20. NPR (New Production Reactor) capacity cost evaluation

    SciTech Connect (OSTI)

    1988-07-01

    The ORNL Cost Evaluation Technical Support Group (CETSG) has been assigned by DOE-HQ Defense Programs (DP) the task defining, obtaining, and evaluating the capital and life-cycle costs for each of the technology/proponent/site/revenue possibilities envisioned for the New Production Reactor (NPR). The first part of this exercise is largely one of accounting, since all NPR proponents use different accounting methodologies in preparing their costs. In order to address this problem of comparing ''apples and oranges,'' the proponent-provided costs must be partitioned into a framework suitable for all proponents and concepts. If this is done, major cost categories can then be compared between concepts and major cost differences identified. Since the technologies proposed for the NPR and its needed fuel and target support facilities vary considerably in level of technical and operational maturity, considerable care must be taken to evaluate the proponent-derived costs in an equitable manner. The use of cost-risk analysis along with derivation of single point or deterministic estimates allows one to take into account these very real differences in technical and operational maturity. Chapter 2 summarizes the results of this study in tabular and bar graph form. The remaining chapters discuss each generic reactor type as follows: Chapter 3, LWR concepts (SWR and WNP-1); Chapter 4, HWR concepts; Chapter 5, HTGR concept; and Chapter 6, LMR concept. Each of these chapters could be a stand-alone report. 39 refs., 36 figs., 115 tabs.

  1. sup 1 H and sup 31 P-NMR assignments of the non-exchangeable protons of the consensus acceptor exon:intron junction d(CpTpApCpApGpGpT)

    SciTech Connect (OSTI)

    Lown, J.W.; Chang, D.K.; Debart, F.; Rayner, B.; Imbach, J.L. )

    1986-06-01

    The consensus acceptor exon:intron junction d(CpTpApCpApGpGpT) has been synthesized by a modified phosphotriester method. The non-self complementary octamer exists in the single strand form in aqueous buffer at 20 degrees C as evidenced by temperature variable {sup 1}H-NMR and NOE measurements. The non-exchangeable proton assignments were secured using a combination of techniques including two-dimensional COSY, NOESY and the double quantum technique {sup 1}H-{sup 1}H-INADEQUATE as well as inversion recovery T1 experiments. The new technique of {sup 31}P-1H shift correlation is particularly valuable in removing certain ambiguities in the sugar proton assignments. Characteristic chemical shifts for the base protons which are determined by their immediate molecular environments are also useful in assignments. The consensus acceptor exon:intron junction adopts a random coil conformation in solution under the experimental conditions employed.

  2. Identification of a distinct type IV collagen. alpha. chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome

    SciTech Connect (OSTI)

    Hostikka, S.L.; Hoeyhtyae, M.; Tryggvason, K. ); Eddy, R.L.; Byers, M.G.; Shows, T.B. )

    1990-02-01

    The authors have identified and extensively characterized a type IV collagen {alpha} chain, referred to as {alpha}5(IV). Four overlapping cDNA clones isolated contain an open reading frame for 543 amino acid residues of the carboxyl-terminal end of a collagenous domain, a 229-residue carboxyl-terminal noncollagenous domain, and 1201 base pairs coding for a 3{prime} untranslated region. The collagenous Gly-Xaa-Yaa repeat sequence has five imperfections that coincide with those in the corresponding region of the {alpha}1(IV) chain. The noncollagenous domain has 12 conserved cysteine residues and 83% and 63% sequence identity with the noncollagenous domains of the {alpha}1(IV) and {alpha}2(IV) chains, respectively. The {alpha}5(IV) chain has less sequence identity with the putative bovine {alpha}3(IV) and {alpha}4(IV) chains. Antiserum against an {alpha}5(IV) synthetic peptide stained a polypeptide chain of about 185 kDa by immunoblot analysis and immunolocalization of the chain in human kidney was almost completely restricted to the glomerulus. The gene was assigned to the Xq22 locus by somatic cell hybrids and in situ hybridization. This may be identical or close to the locus of the X chromosome-linked Alport syndrome that is believed to be a type IV collagen disease.

  3. Evaluation Project 4492

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Organization area to allow the movement and radio-graphing of component for evaluation to determine the proper Project Execution Plan for dismantlement. Evaluation Project...

  4. Linking Automated Data Analysis and Visualization with Applications in Developmental Biology and High-Energy Physics

    SciTech Connect (OSTI)

    Ruebel, Oliver

    2009-12-01

    Knowledge discovery from large and complex collections of today's scientific datasets is a challenging task. With the ability to measure and simulate more processes at increasingly finer spatial and temporal scales, the increasing number of data dimensions and data objects is presenting tremendous challenges for data analysis and effective data exploration methods and tools. Researchers are overwhelmed with data and standard tools are often insufficient to enable effective data analysis and knowledge discovery. The main objective of this thesis is to provide important new capabilities to accelerate scientific knowledge discovery form large, complex, and multivariate scientific data. The research covered in this thesis addresses these scientific challenges using a combination of scientific visualization, information visualization, automated data analysis, and other enabling technologies, such as efficient data management. The effectiveness of the proposed analysis methods is demonstrated via applications in two distinct scientific research fields, namely developmental biology and high-energy physics.Advances in microscopy, image analysis, and embryo registration enable for the first time measurement of gene expression at cellular resolution for entire organisms. Analysis of high-dimensional spatial gene expression datasets is a challenging task. By integrating data clustering and visualization, analysis of complex, time-varying, spatial gene expression patterns and their formation becomes possible. The analysis framework MATLAB and the visualization have been integrated, making advanced analysis tools accessible to biologist and enabling bioinformatic researchers to directly integrate their analysis with the visualization. Laser wakefield particle accelerators (LWFAs) promise to be a new compact source of high-energy particles and radiation, with wide applications ranging from medicine to physics. To gain insight into the complex physical processes of particle

  5. RELAP5-3D Developmental Assessment: Comparison of Version 4.2.1i on Linux and Windows

    SciTech Connect (OSTI)

    Paul D. Bayless

    2014-06-01

    Figures have been generated comparing the parameters used in the developmental assessment of the RELAP5-3D code, version 4.2i, compiled on Linux and Windows platforms. The figures, which are the same as those used in Volume III of the RELAP5-3D code manual, compare calculations using the semi-implicit solution scheme with available experiment data. These figures provide a quick, visual indication of how the code predictions differ between the Linux and Windows versions.

  6. RELAP5-3D Developmental Assessment. Comparison of Version 4.3.4i on Linux and Windows

    SciTech Connect (OSTI)

    Bayless, Paul David

    2015-10-01

    Figures have been generated comparing the parameters used in the developmental assessment of the RELAP5-3D code, version 4.3i, compiled on Linux and Windows platforms. The figures, which are the same as those used in Volume III of the RELAP5-3D code manual, compare calculations using the semi-implicit solution scheme with available experiment data. These figures provide a quick, visual indication of how the code predictions differ between the Linux and Windows versions.

  7. Evaluation Consultant RFP

    Broader source: Energy.gov [DOE]

    Evaluation Consultant RFP, from the Tool Kit Framework: Small Town University Energy Program (STEP).

  8. Preliminary Impact Evaluation BBNP

    Broader source: Energy.gov [DOE]

    Preliminary Impact Evaluation of the U.S. Department of Energy's Better Buildings Neighborhood Program, 2013.

  9. Evaluation of Potential Impacts of Microbial Activity on Drift Chemistry

    SciTech Connect (OSTI)

    Y. Wang

    2004-11-18

    ''Evaluation of Potential Impacts of Microbial Activity on Drift Chemistry'' focuses on the potential for microbial communities that could be active in repository emplacement drifts to influence the in-drift bulk chemical environment. This report feeds analyses to support the inclusion or exclusion of features, events, and processes (FEPs) in the total system performance assessment (TSPA) for the license application (LA), but this work is not expected to generate direct feeds to the TSPA-LA. The purpose was specified by, and the evaluation was performed and is documented in accordance with, ''Technical Work Plan For: Near-Field Environment and Transport In-Drift Geochemistry Analyses'' (BSC 2004 [DIRS 172402], Section 2.1). This report addresses all of the FEPs assigned by the technical work plan (TWP), including the development of exclusion arguments for FEPs that are not carried forward to the TSPA-LA. Except for an editorial correction noted in Section 6.2, there were no other deviations from the TWP. This report documents the completion of all assigned tasks, as follows (BSC 2004 DIRS 172402, Section 1.2.1): (1) Perform analyses to evaluate the potential for microbial activity in the waste emplacement drift under the constraints of anticipated physical and chemical conditions. (2) Evaluate uncertainties associated with these analyses. (3) Determine whether the potential for microbes warrants a feed to TSPA-LA to account for predicted effects on repository performance. (4) Provide information to address the ''Yucca Mountain Review Plan, Final Report'' (NUREG-1804) (NRC 2003 [DIRS 163274]) and Key Technical Issues and agreements, as appropriate. (5) Develop information for inclusion or exclusion of FEPs.

  10. Safeguards Analytical Laboratory Evaluation (SALE) 1979 annual report

    SciTech Connect (OSTI)

    Not Available

    1980-07-01

    The data in this report indicate that reliability of measurements is probably more closely associated with the methods of measurement employed by the laboratories than with any other factor. However, since other laboratories use, with success, the same methods that show some diversity in laboratory means with success, it must be concluded that factors relating to measurement control within a given laboratory may be responsible for inaccurate or imprecise results. The relatively small quantity of data reported for the analysis of plutonium-bearing materials does not permit an in-depth evaluation of measurement performance. The data demonstrate that random and systematic errors associated with uranium measurements are within acceptable limits and that measurement performance in the analysis of low enriched uranium can be considered as good to excellent. The measurement performance related to plutonium-bearing materials appears to be acceptable based on the limited data available. However, developmental activities designed to improve plutonium measurement technology should be expedited.

  11. Program Evaluation: Planning and Conducting Evaluations

    Broader source: Energy.gov [DOE]

    This area of the website takes you through step-by-step processes for planning and conducting the In-progress Peer Reviews and Impact Evaluations described on this website. In general, for each...

  12. Program Evaluation: Monitor Implementation

    Broader source: Energy.gov [DOE]

    Once you have chosen the evaluation contractor, the next step is to work with the contractor to get the evaluation plan finalized and to provide the lists and other assistance the contractor needs....

  13. Technical and systems evaluations

    SciTech Connect (OSTI)

    Skolnik, E.G.; DiPietro, J.P.

    1998-08-01

    During FY 1998 Energetics performed a variety of technology-based evaluations for the Hydrogen Program. Three evaluations are summarized below: hydrogen bromine-based electricity storage, carbon-based hydrogen storage, and hydrogen-fueled buses.

  14. The Partnership Evaluation Framework

    Broader source: Energy.gov [DOE]

    U.S. Department of Energy Better Buildings Neighborhood Program: The Partnership Evaluation Framework: How to evaluate a potential partner’s business model and identify areas for collaboration.

  15. Program Evaluation: Lessons Learned

    Broader source: Energy.gov [DOE]

    A number of lessons have been learned from implementing peer reviews and critiques of past (pre-2006) outcome/impact evaluation studies that will help improve evaluation practice in EERE. Awareness...

  16. Advanced Vehicle Testing & Evaluation

    Broader source: Energy.gov [DOE]

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  17. Advanced Vehicle Testing & Evaluation

    Broader source: Energy.gov [DOE]

    2012 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  18. Advanced Vehicle Testing & Evaluation

    Broader source: Energy.gov [DOE]

    2011 DOE Hydrogen and Fuel Cells Program, and Vehicle Technologies Program Annual Merit Review and Peer Evaluation

  19. Who's Evaluating What? Planned Program Evaluations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Who's Evaluating What? Planned Program Evaluations Who's Evaluating What? Planned Program Evaluations Better Buildings Peer Exchange Call, Who's Evaluating What? - Planned Program Evaluations, November 17, 2011. During this call participants shared their evaluation plans and initial results and discussed DOE and fellow programs' evaluation efforts. Discussion Summary (530.03 KB) More Documents & Publications Process Evaluation of the Better Buildings Neighborhood Program, Final Evaluation

  20. Aroclor 1254, a developmental neurotoxicant, alters energy metabolism- and intracellular signaling-associated protein networks in rat cerebellum and hippocampus

    SciTech Connect (OSTI)

    Kodavanti, Prasada Rao S.; Osorio, Cristina; Program on Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, North Carolina ; Royland, Joyce E.; Ramabhadran, Ram; Alzate, Oscar; Systems Proteomics Center, University of North Carolina at Chapel Hill, North Carolina; Program on Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, North Carolina

    2011-11-15

    The vast literature on the mode of action of polychlorinated biphenyls (PCBs) indicates that PCBs are a unique model for understanding the mechanisms of toxicity of environmental mixtures of persistent chemicals. PCBs have been shown to adversely affect psychomotor function and learning and memory in humans. Although the molecular mechanisms for PCB effects are unclear, several studies indicate that the disruption of Ca{sup 2+}-mediated signal transduction plays significant roles in PCB-induced developmental neurotoxicity. Culminating events in signal transduction pathways include the regulation of gene and protein expression, which affects the growth and function of the nervous system. Our previous studies showed changes in gene expression related to signal transduction and neuronal growth. In this study, protein expression following developmental exposure to PCB is examined. Pregnant rats (Long Evans) were dosed with 0.0 or 6.0 mg/kg/day of Aroclor-1254 from gestation day 6 through postnatal day (PND) 21, and the cerebellum and hippocampus from PND14 animals were analyzed to determine Aroclor 1254-induced differential protein expression. Two proteins were found to be differentially expressed in the cerebellum following PCB exposure while 18 proteins were differentially expressed in the hippocampus. These proteins are related to energy metabolism in mitochondria (ATP synthase, sub unit {beta} (ATP5B), creatine kinase, and malate dehydrogenase), calcium signaling (voltage-dependent anion-selective channel protein 1 (VDAC1) and ryanodine receptor type II (RyR2)), and growth of the nervous system (dihydropyrimidinase-related protein 4 (DPYSL4), valosin-containing protein (VCP)). Results suggest that Aroclor 1254-like persistent chemicals may alter energy metabolism and intracellular signaling, which might result in developmental neurotoxicity. -- Highlights: Black-Right-Pointing-Pointer We performed brain proteomic analysis of rats exposed to the neurotoxicant

  1. Hanford performance evaluation program for Hanford site analytical services

    SciTech Connect (OSTI)

    Markel, L.P.

    1995-09-01

    The U.S. Department of Energy (DOE) Order 5700.6C, Quality Assurance, and Title 10 of the Code of Federal Regulations, Part 830.120, Quality Assurance Requirements, states that it is the responsibility of DOE contractors to ensure that ``quality is achieved and maintained by those who have been assigned the responsibility for performing the work.`` Hanford Analytical Services Quality Assurance Plan (HASQAP) is designed to meet the needs of the Richland Operations Office (RL) for maintaining a consistent level of quality for the analytical chemistry services provided by contractor and commmercial analytical laboratory operations. Therefore, services supporting Hanford environmental monitoring, environmental restoration, and waste management analytical services shall meet appropriate quality standards. This performance evaluation program will monitor the quality standards of all analytical laboratories supporting the Hanforad Site including on-site and off-site laboratories. The monitoring and evaluation of laboratory performance can be completed by the use of several tools. This program will discuss the tools that will be utilized for laboratory performance evaluations. Revision 0 will primarily focus on presently available programs using readily available performance evaluation materials provided by DOE, EPA or commercial sources. Discussion of project specific PE materials and evaluations will be described in section 9.0 and Appendix A.

  2. American Evaluation Association Guiding Principles for Evaluators, 2004 |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy American Evaluation Association Guiding Principles for Evaluators, 2004 American Evaluation Association Guiding Principles for Evaluators, 2004 Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles they can expect to be upheld by professional evaluators. Guiding Principles for Evaluators (204.88 KB) More Documents & Publications ORSSAB

  3. Developmental test report, assessment of XT-70E percussion drill rig operation in tank farms

    SciTech Connect (OSTI)

    Dougherty, L.F., Westinghouse Hanford

    1996-09-10

    The following report documents the testing of the XT-70E percussion drill rig for use in the 241-SX Tank Farm. The test is necessary to support evaluation of the safety and authorization level of the proposed activity of installing up to three new drywells in the 241- SX Tank Farm. The proposed activity plans to install drywells by percussion drilling 7 inch O.D./6 inch I.D. pipe in close proximity of underground storage tanks and associated equipment. The load transmitted from the drill rig`s percussion hammer through the ground to the tank structure and equipment is not known and therefore testing is required to ensure the activity is safe and authorized.

  4. Exposure Evaluation Process

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Exposure Evaluation Process for Tank Farm Workers L.B. Sandy Rock, MD, MPH Risk Communication HPMC Occupational Medical Services An increase in the number of tank farm vapor exposures has led to many questions and concerns among workers and management. * During regular clinic hours, HPMC OMS is responsible for the medical evaluation of workers reporting exposure to vapors. * At other times, workers are taken to Kadlec Hospital which has an arrangement with DOE/HPMC OMS to evaluate, treat, refer

  5. ORISE: Research and Evaluation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    are built on solid research and evaluation. This information helps agencies refine the design, implementation and overall quality of a communication intervention. To support the...

  6. Service Center Evaluation Guide

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Evaluation Guide, Selected Bibliography on Electric Motor Repair, Model Repair Specifications for Low Voltage Motors, and Motor Repair Tech Brief- were produced by the U.S. ...

  7. Precursor and Fiber Evaluation

    Broader source: Energy.gov [DOE]

    2009 DOE Hydrogen Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting, May 18-22, 2009 -- Washington D.C.

  8. MSA Evaluation Archive

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Education Teachers (K-12) Archive MSA Evaluation Archive The Laboratory's Math and Science Academy provides quality STEM education professional development for teachers in...

  9. Evaluation Project 4492

    National Nuclear Security Administration (NNSA)

    the Kansas City Plant (KCP) in Kansas City, Missouri to evaluate parts that have undergone testing. Sandia Site Office Postmortem Code Blue--Kansas City Plant (KCP) Kansas ...

  10. Fast Neutron Detection Evaluation

    SciTech Connect (OSTI)

    McKigney, Edward A.; Stange, Sy

    2014-03-17

    These slides present a summary of previous work, conclusions, and anticipated schedule for the conclusion of our fast neutron detection evaluation.

  11. test and evaluation

    National Nuclear Security Administration (NNSA)

    5%2A en Office of Test and Evaluation http:nnsa.energy.govaboutusourprogramsdefenseprogramsstockpilestewardshiptestcapabilitiesand-eval

  12. Project Evaluation Models

    Office of Environmental Management (EM)

    ... to evaluate its performance and lowest cost of energy * Uses hourly resource data for wind and solar Renewable Energy Options * Models existing generation (Grid, backup ...

  13. Program Evaluation: Use the Results

    Broader source: Energy.gov [DOE]

    Communicating and disseminating the evaluation findings is a critical step in building support for utilizing those findings. Managers of the evaluation and evaluators should plan the reporting...

  14. MSA Evaluation Archive

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Education » Teachers (K-12) » Archive MSA Evaluation Archive The Laboratory's Math and Science Academy provides quality STEM education professional development for teachers in participating schools and districts. Contact Math and Science Academy Community Partnerships Office (505) 665-4400 MSA Program Evaluations FY13-14 (pdf) FY12-13 (pdf) FY11-12

  15. Developmentally regulated expression by Trypanosoma cruzi of molecules that accelerate the decay of complement C3 convertases

    SciTech Connect (OSTI)

    Rimoldi, M.T.; Sher, A.; Heiny, A.; Lituchy, A.; Hammer, C.H.; Joiner, K.

    1988-01-01

    The authors recently showed that culture-derived metacyclic trypomastigotes (CMT), but not epimastigotes (Epi), of the Miranda 99 strain of Trypanosoma cruzi evade lysis by the human alternative complement pathway because of inefficient binding of factor B to complement component C3b on the parasite surface. These results suggested that CMT and tissue-culture-derived trypomastigotes (TCT), which also activate the alternative pathway poorly, might produce a molecule capable of interfering with factor B binding to C3b. They now demonstrate that CMT and TCT lysates, as well as molecules spontaneously shed from CMT and TCT but not Epi, accelerate decay of /sup 125/I-labeled factor Bb from the alternative-pathway C3 convertase (C3bBb) assembled on zymosan or Epi and also accelerate decay of the classical-pathway C3 convertase (C4b2a) on sheep erythrocytes. Parasites metabolically labeled with (/sup 35/S)methionine spontaneously shed a limited number of radioactive components, ranging in molecular mass from 86 to 155 kDa for trypomastigotes and 25 to 80 kDa for Epi. Decay-accelerating activity within supernatants is inactivated by papain and is coeluted with /sup 35/S-containing polypeptides on FPLC anion-exchange chromatography, suggesting that the active constituents are protein molecules. Molecules with decay-accelerating activity may explain the developmentally regulated resistance to complement-mediated lysis in infective and vertebrate stages for T. cruzi life cycle.

  16. Design and evaluation of small water turbines. Final report

    SciTech Connect (OSTI)

    Marquis, J.A.

    1983-02-17

    An evaluation was made of the design and hydromechanical performance characteristics for three basic turbine types: axial flow (Jonval), inward radial flow (Francis) and crossflow (Banki). A single commercially available turbine representative of each type and within the appropriate power range (<5hp) was obtained for evaluation. Specific turbine selections were based on price, availability and suitability for operation at heads of 50 feet or less and flows under 2 cubic feet per second. In general, the peak operating efficiencies of each unit tended to be lower than anticipated, falling in the range of 40 to 50%. With sufficient flow, however, significant useful power outputs up to 3 hp were obtained. While the radial flow turbine (a centrifugal pump operated as a turbine) had the lowest initial unit cost, the axial and cross flow designs exhibited more stable operation, particularly under transient loadings. The crossflow turbine had the added advantage that it was essentially self-cleaning. With further developmental effort and appropriate design modifications it should be possible to bring each of these microhydro designs to their full performance potential.

  17. Service Center Evaluation Guide

    Office of Energy Efficiency and Renewable Energy (EERE)

    To be assured of a quality product, customers of motor repair service centers need to be knowledgeable about the service they're purchasing. This guide provides information to assist in evaluating motor repair service centers.

  18. Internal Controls Evaluations

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    4, 2016 U.S. DEPARTMENT OF ENERGY Internal Control Evaluations Fiscal Year 2016 Guidance Page | 2 Table of Contents I. Introduction .............................................................................................................................................. 4 A. Background ......................................................................................................................................... 4 B. New for FY

  19. BUILDING 341 Seismic Evaluation

    SciTech Connect (OSTI)

    Halle, J.

    2015-06-15

    The Seismic Evaluation of Building 341 located at Lawrence Livermore National Laboratory in Livermore, California has been completed. The subject building consists of a main building, Increment 1, and two smaller additions; Increments 2 and 3.

  20. Market Effects Evaluation Report

    Office of Energy Efficiency and Renewable Energy (EERE)

    A report evaluating the U.S. Department of Energy Solid State Lighting Program for FY 2006 – FY 2012 to determine its effectiveness and progress toward achieving program objectives and to assess...

  1. Evaluated Nuclear Data

    SciTech Connect (OSTI)

    Oblozinsky, P.; Oblozinsky,P.; Herman,M.; Mughabghab,S.F.

    2010-10-01

    This chapter describes the current status of evaluated nuclear data for nuclear technology applications. We start with evaluation procedures for neutron-induced reactions focusing on incident energies from the thermal energy up to 20 MeV, though higher energies are also mentioned. This is followed by examining the status of evaluated neutron data for actinides that play dominant role in most of the applications, followed by coolants/moderators, structural materials and fission products. We then discuss neutron covariance data that characterize uncertainties and correlations. We explain how modern nuclear evaluated data libraries are validated against an extensive set of integral benchmark experiments. Afterwards, we briefly examine other data of importance for nuclear technology, including fission yields, thermal neutron scattering and decay data. A description of three major evaluated nuclear data libraries is provided, including the latest version of the US library ENDF/B-VII.0, European JEFF-3.1 and Japanese JENDL-3.3. A brief introduction is made to current web retrieval systems that allow easy access to a vast amount of up-to-date evaluated nuclear data for nuclear technology applications.

  2. Survey of the high resolution infrared spectrum of methane ({sup 12}CH{sub 4} and {sup 13}CH{sub 4}): Partial vibrational assignment extended towards 12000 cm{sup ?1}

    SciTech Connect (OSTI)

    Ulenikov, O. N.; Bekhtereva, E. S.; Albert, S.; Bauerecker, S.; Niederer, H. M.; Quack, M.

    2014-12-21

    We have recorded the complete infrared spectrum of methane {sup 12}CH{sub 4} and its second most abundant isotopomer {sup 13}CH{sub 4} extending from the fundamental range starting at 1000 cm{sup ?1} up to the overtone region near 12000 cm{sup ?1} in the near infrared at the limit towards the visible range, at temperatures of about 80 K and also at 298 K with Doppler limited resolution in the gas phase by means of interferometric Fourier transform spectroscopy using the Bruker IFS 125 HR prototype (ZP 2001) of the ETH Zrich laboratory. This provides the so far most complete data set on methane spectra in this range at high resolution. In the present work we report in particular those results, where the partial rovibrational analysis allows for the direct assignment of pure (J = 0) vibrational levels including high excitation. These results substantially extend the accurate knowledge of vibrational band centers to higher energies and provide a benchmark for both the comparison with theoretical results on the one hand and atmospheric spectroscopy on the other hand. We also present a simple effective Hamiltonian analysis, which is discussed in terms of vibrational level assignments and {sup 13}C isotope effects.

  3. Millimeter-wave optical double resonance schemes for rapid assignment of perturbed spectra, with applications to the C{sup ~} {sup 1}B{sub 2} state of SO{sub 2}

    SciTech Connect (OSTI)

    Park, G. Barratt E-mail: barratt.park@gmail.com; Womack, Caroline C.; Jiang, Jun; Field, Robert W.; Whitehill, Andrew R.; Ono, Shuhei

    2015-04-14

    Millimeter-wave detected, millimeter-wave optical double resonance (mmODR) spectroscopy is a powerful tool for the analysis of dense, complicated regions in the optical spectra of small molecules. The availability of cavity-free microwave and millimeter wave spectrometers with frequency-agile generation and detection of radiation (required for chirped-pulse Fourier-transform spectroscopy) opens up new schemes for double resonance experiments. We demonstrate a multiplexed population labeling scheme for rapid acquisition of double resonance spectra, probing multiple rotational transitions simultaneously. We also demonstrate a millimeter-wave implementation of the coherence-converted population transfer scheme for background-free mmODR, which provides a ∼10-fold sensitivity improvement over the population labeling scheme. We analyze perturbations in the C{sup ~} state of SO{sub 2}, and we rotationally assign a b{sub 2} vibrational level at 45 328 cm{sup −1} that borrows intensity via a c-axis Coriolis interaction. We also demonstrate the effectiveness of our multiplexed mmODR scheme for rapid acquisition and assignment of three predissociated vibrational levels of the C{sup ~} state of SO{sub 2} between 46 800 and 47 650 cm{sup −1}.

  4. MODULAR CONSTRUCTION SYSTEM EVALUATION

    SciTech Connect (OSTI)

    S. Gillespie

    2002-08-08

    The purpose of this study is to respond to U.S. Department of Energy (DOE) Technical Direction Letter (TDL) 02-003 (Waisley 2001), which directs Bechtel SAIC Company, LLC (BSC) to complete a design study to recommend repository design options to support receipt and/or emplacement of any or all of the following: commercial spent nuclear fuel (CSNF), high-level radioactive waste (HLW), DOE-managed spent nuclear fuel (DSNF) (including naval spent nuclear fuel [SNF]), and immobilized plutonium (if available), as soon as practicable, but no later than 2010. From the possible design options, a recommended approach will be determined for further evaluation to support the preliminary design of the repository. This study integrates the results of the repository Design Evolution Study (Rowe 2002) with supporting studies concerning national transportation options (BSC 2002b) and Nevada transportation options (Gehner 2002). The repository Design Evolution Study documents the processes used to reevaluate the design, construction, operation, and cost of the repository in response to TDL 02-003 (Waisley 2001), and to determine possible repository conceptual design options. The transportation studies evaluate the national and Nevada transportation options that support the repository conceptual design options. An evaluation methodology was established, based on Program-level requirements developed for the study in reference BSC 2001a, to allow the repository and system design options to be evaluated on a consistent basis. The transportation options and the design components were integrated into system design implementation options, which were evaluated using receipt and emplacement scenarios. The scenarios tested the ability of the design concept to adapt to changes in funding, waste receipt rate, and Nevada rail transportation availability. The results of the evaluation (in terms of system throughput, cost, and schedule) were then compared to the Program-level requirements, and

  5. Program Evaluation: EERE Planned and Completed Evaluations | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Evaluation » Information Resources » Program Evaluation: EERE Planned and Completed Evaluations Program Evaluation: EERE Planned and Completed Evaluations This section provides a list of past and planned evaluation reports for the U.S. Department of Energy's (DOE) Office of Energy Efficiency and Renewable Energy (EERE). Many of the listed reports are available as downloads. The table below tells you which offices have reports accessible as downloads. A checked box in the table -

  6. Hydrogen and Fuel Cell Transit Bus Evaluations: Joint Evaluation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Administration; Appendix Hydrogen and Fuel Cell Transit Bus Evaluations: Joint Evaluation Plan for the U.S. Department of Energy and the Federal Transit Administration; Appendix ...

  7. Hydrogen and Fuel Cell Transit Bus Evaluations: Joint Evaluation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Administration Hydrogen and Fuel Cell Transit Bus Evaluations: Joint Evaluation Plan for the U.S. Department of Energy and the Federal Transit Administration This document ...

  8. Evaluation of accountability measurements

    SciTech Connect (OSTI)

    Cacic, C.G.

    1988-01-01

    The New Brunswick Laboratory (NBL) is programmatically responsible to the U.S. Department of Energy (DOE) Office of Safeguards and Security (OSS) for providing independent review and evaluation of accountability measurement technology in DOE nuclear facilities. This function is addressed in part through the NBL Safegaurds Measurement Evaluation (SME) Program. The SME Program utilizes both on-site review of measurement methods along with material-specific measurement evaluation studies to provide information concerning the adequacy of subject accountability measurements. This paper reviews SME Program activities for the 1986-87 time period, with emphasis on noted improvements in measurement capabilities. Continued evolution of the SME Program to respond to changing safeguards concerns is discussed.

  9. Soil washing technology evaluation

    SciTech Connect (OSTI)

    Suer, A.

    1995-04-01

    Environmental Restoration Engineering (ERE) continues to review innovative, efficient, and cost effective technologies for SRS soil and/or groundwater remediation. As part of this effort, this technical evaluation provides review and the latest information on the technology for SRS soil remediation. Additional technology evaluation reports will be issued periodically to update these reports. The purpose of this report is to review the soil washing technology and its potential application to SRS soil remediation. To assess whether the Soil Washing technology is a viable option for SRS soil remediation, it is necessary to review the technology/process, technology advantages/limitations, performance, applications, and cost analysis.

  10. Impaired Chloroplast Biogenesis in Immutans, an Arabidopsis Variegation Mutant, Modifies Developmental Programming, Cell Wall Composition and Resistance to Pseudomonas syringae

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Pogorelko, Gennady V.; Kambakam, Sekhar; Nolan, Trevor; Foudree, Andrew; Zabotina, Olga A.; Rodermel, Steven R.

    2016-04-06

    The immutans (im) variegation mutation of Arabidopsis has green- and white- sectored leaves due to action of a nuclear recessive gene. IM codes for PTOX, a plastoquinol oxidase in plastid membranes. Previous studies have revealed that the green and white sectors develop into sources (green tissues) and sinks (white tissues) early in leaf development. In this report we focus on white sectors, and show that their transformation into effective sinks involves a sharp reduction in plastid number and size. Despite these reductions, cells in the white sectors have near-normal amounts of plastid RNA and protein, and surprisingly, a marked amplificationmore » of chloroplast DNA. The maintenance of protein synthesis capacity in the white sectors might poise plastids for their development into other plastid types. The green and white im sectors have different cell wall compositions: whereas cell walls in the green sectors resemble those in wild type, cell walls in the white sectors have reduced lignin and cellulose microfibrils, as well as alterations in galactomannans and the decoration of xyloglucan. These changes promote susceptibility to the pathogen Pseudomonas syringae. Enhanced susceptibility can also be explained by repressed expression of some, but not all, defense genes. We suggest that differences in morphology, physiology and biochemistry between the green and white sectors is caused by a reprogramming of leaf development that is coordinated, in part, by mechanisms of retrograde (plastid-tonucleus) signaling, perhaps mediated by ROS. Lastly, we conclude that variegation mutants offer a novel system to study leaf developmental programming, cell wall metabolism and hostpathogen interactions.« less

  11. THE AIMS AND ACTIVITIES OF THE INTERNATIONAL NETWORK OF NUCLEAR STRUCTURE AND DECAY DATA EVALUATORS.

    SciTech Connect (OSTI)

    NICHOLS,A.L.; TULI, J.K.

    2007-04-22

    International Network of Nuclear Structure and Decay Data (NSDD) Evaluators consists of a number of evaluation groups and data service centers in several countries that appreciate the merits of working together to maintain and ensure the quality and comprehensive content of the ENSDF database (Evaluated Nuclear Structure Data File). Biennial meetings of the network are held under the auspices of the International Atomic Energy Agency (IAEA) to assign evaluation responsibilities, monitor progress, discuss improvements and emerging difficulties, and agree on actions to be undertaken by individual members. The evaluated data and bibliographic details are made available to users via various media, such as the journals ''Nuclear Physics A'' and ''Nuclear Data Sheets'', the World Wide Web, on CD-ROM, wall charts of the nuclides and ''Nuclear Wallet Cards''. While the ENSDF master database is maintained by the US National Nuclear Data Center at the Brookhaven National Laboratory, these data are also available from other nuclear data centers including the IAEA Nuclear Data Section. The Abdus Salam International Centre for Theoretical Physics (ICTP), Trieste, Italy, in cooperation with the IAEA, organizes workshops on NSDD at regular intervals. The primary aims of these particular workshops are to provide hands-on training in the data evaluation processes, and to encourage new evaluators to participate in NSDD activities. The technical contents of these NSDD workshops are described, along with the rationale for the inclusion of various topics.

  12. Continuous Evaluation of Fast Processes...

    Office of Scientific and Technical Information (OSTI)

    FASTER project Continuous Evaluation of Fast Processes in Climate Models Using Arm ... development and evaluation of convection and cloud parameterizations in climate models. ...

  13. TUNL Nuclear Data Evaluation Group

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TUNL Nuclear Data Evaluation Group As a part of the United States Nuclear Data Network and the international Nuclear Structure and Decay Data Evaluators' Network, the Nuclear Data...

  14. Program Evaluation: Requirements and Expectations

    Broader source: Energy.gov [DOE]

    Throughout this website, emphasis is placed on evaluation as a good management practice that helps managers make informed decisions. Ideally, offices are motivated to undertake evaluation-related...

  15. Program Evaluation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Program Evaluation The Office of Energy Efficiency and Renewable Energy (EERE) takes an active role in measuring and evaluating its projects and programs. One focus of these ...

  16. Programs Planning to Do Evaluations

    Broader source: Energy.gov [DOE]

    Better Buildings Neighborhood Program Data and Evaluation Peer Exchange Call: Programs Planning to Do Evaluations, Call Slides and Discussion Summary, August 2, 2012.

  17. A=3, 2010 evaluation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 (2010PU04) (Revised Manuscript from 2010) An evaluation of A = 3 was published in Nuclear Physics A848 (2010) p. 1. The version here differs from the published version in that we have corrected a few errors discovered after the article went to press. PDF HTML A = 3 3n, 3H, 3He, 3Li Adobe Reader Download Last modified: 01

  18. Use of genomic data in risk assessment case study: I. Evaluation of the dibutyl phthalate male reproductive development toxicity data set

    SciTech Connect (OSTI)

    Makris, Susan L.; Euling, Susan Y.; Gray, L. Earl; Benson, Robert; Foster, Paul M.D.

    2013-09-15

    A case study was conducted, using dibutyl phthalate (DBP), to explore an approach to using toxicogenomic data in risk assessment. The toxicity and toxicogenomic data sets relative to DBP-related male reproductive developmental outcomes were considered conjointly to derive information about mode and mechanism of action. In this manuscript, we describe the case study evaluation of the toxicological database for DBP, focusing on identifying the full spectrum of male reproductive developmental effects. The data were assessed to 1) evaluate low dose and low incidence findings and 2) identify male reproductive toxicity endpoints without well-established modes of action (MOAs). These efforts led to the characterization of data gaps and research needs for the toxicity and toxicogenomic studies in a risk assessment context. Further, the identification of endpoints with unexplained MOAs in the toxicity data set was useful in the subsequent evaluation of the mechanistic information that the toxicogenomic data set evaluation could provide. The extensive analysis of the toxicology data set within the MOA context provided a resource of information for DBP in attempts to hypothesize MOAs (for endpoints without a well-established MOA) and to phenotypically anchor toxicogenomic and other mechanistic data both to toxicity endpoints and to available toxicogenomic data. This case study serves as an example of the steps that can be taken to develop a toxicological data source for a risk assessment, both in general and especially for risk assessments that include toxicogenomic data.

  19. Borehole Logging Methods for Exploration and Evaluation of Uranium...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for Models Used for Calibration of Gross-Count Gamma-Ray Logging Systems (December 1983) Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984

  20. FRAPCON-2 Developmental Assessment

    SciTech Connect (OSTI)

    Berna, G. A.; Lanning, D. D.; Rausch, W. N.

    1981-07-01

    FRAPCON-2 calculations using all mechanical and gas release options are compared with well-characterized experimental data and with calculations of generic fuel rod response by FRAPCON-1. These comparisons indicate that FRAPCON-2 is capable of analyzing the fuel rod response for the wide range of cases for which the code was designed and compares well with experimental data.

  1. Candidate Assembly Statistical Evaluation

    Energy Science and Technology Software Center (OSTI)

    1998-07-15

    The Savannah River Site (SRS) receives aluminum clad spent Material Test Reactor (MTR) fuel from all over the world for storage and eventual reprocessing. There are hundreds of different kinds of MTR fuels and these fuels will continue to be received at SRS for approximately ten more years. SRS''s current criticality evaluation methodology requires the modeling of all MTR fuels utilizing Monte Carlo codes, which is extremely time consuming and resource intensive. Now that amore » significant number of MTR calculations have been conducted it is feasible to consider building statistical models that will provide reasonable estimations of MTR behavior. These statistical models can be incorporated into a standardized model homogenization spreadsheet package to provide analysts with a means of performing routine MTR fuel analyses with a minimal commitment of time and resources. This became the purpose for development of the Candidate Assembly Statistical Evaluation (CASE) program at SRS.« less

  2. A=11, 2012 evaluation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    11 (2012KE01) (Revised Manuscript from 2012) An evaluation of A = 11 was published in Nuclear Physics A880 (2012) p. 88. The version here differs from the published version in that we have corrected a few errors discovered after the article went to press. PDF HTML A = 11 11He,11Li, 11Be, 11B, , 11C, , 11N, , 11O, , 11F, ,11Ne Adobe Reader Download Last modified: 23 April 2012

  3. Evaluations | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Evaluations It is essential that postdoctoral appointees and supervisors get together within two months of the starting date and fill out the Postdoctoral Initial Discussion form (ANL-698). This discussion sets initial goals and clarifies expectations on both sides for a success and productive relationship. Once completed, it has to be reviewed and signed by the Division Director. A copy should be sent to Kristene (Tina) Henne, Postdoctoral Programs Coordinator, by email to khenne@anl.gov. The

  4. BUILDING AMERICA PROGRAM EVALUATION

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    BUILDING AMERICA PROGRAM EVALUATION _______________________________ Volume I: Main Report Prepared by: Energy Technology Innovation Project (ETIP) Kennedy School of Government, Harvard University Vicki Norberg-Bohm, Principal Investigator Chad White, Lead Author September 2004 Acknowledgements This report is the culmination of a multiple-year effort to study the role of collaboration in technology innovation and public administration. There are many people to be thanked for their involvement and

  5. BUILDING AMERICA PROGRAM EVALUATION

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    BUILDING AMERICA PROGRAM EVALUATION _______________________________ Volume II: Appendices Prepared by: Energy Technology Innovation Project (ETIP) Kennedy School of Government, Harvard University Vicki Norberg-Bohm, Principal Investigator Chad White, Lead Author September 2004 Appendix A. Building America Program Intent and Scope 1 Appendix A-1. Program Overview A-1.1. Program History Building America has its origins in a 1993 pilot project between DOE and a housing products unit at General

  6. Electromelt furnace evaluation

    SciTech Connect (OSTI)

    Reimann, G.A.; Welch, J.M.

    1981-09-01

    An electromelt furnace was designed, built, and operated at the Idaho National Engineering Laboratory to demonstrate the suitability of this equipment for large-scale processing of radioactive wastes in iron-enriched basalt. Several typical waste compositions were melted and cast. The furnace was disassembled and the components evaluated. Calcines and fluorides attacked the furnace lining, unoxidized metals accumulated under the slag, and electrode attrition was high.

  7. Altered cardiovascular reactivity and osmoregulation during hyperosmotic stress in adult rats developmentally exposed to polybrominated diphenyl ethers (PBDEs)

    SciTech Connect (OSTI)

    Shah, Ashini; Coburn, Cary G.; Watson-Siriboe, Abena; Whitley, Rebecca; Shahidzadeh, Anoush; Gillard, Elizabeth R.; Nichol, Robert; Leon-Olea, Martha; Gaertner, Mark; Kodavanti, Prasada Rao S.

    2011-10-15

    h (358.3 {+-} 12.4 mOsm/L) relative to 45 min post hyperosmotic injection (325.1 {+-} 11.4 mOsm/L). Impaired osmoregulation in PBDE-treated animals could not be attributed to decreased levels of plasma vasopressin. Our findings suggest that developmental exposure to PBDEs may disrupt cardiovascular reactivity and osmoregulatory responses to physiological activation in late adulthood. - Highlights: > We examined whether PBDE exposure could impact osmotic and cardiovascular regulation. > Hyperosmotic treatment yielded significant changes in systolic BP in PBDE exposed rats only. > PBDEs may disrupt cardiovascular and osmoregulatory responses to physiological activation.

  8. JOBAID-ASSIGNING AN ALTERNATE SUPERVISOR (SUPERVISOR)

    Broader source: Energy.gov [DOE]

    The purpose of this job aid is to guide you through the step-by-step process of managing alternate supervisors within SuccessFactors Learning.

  9. New Issue: Moody's assigns Aa1 ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    revenue bonds. Rating outlooks are stable. Global Credit Research - 09 Apr 2015 Approximately 8.1 billion of debt securities affected BONNEVILLE POWER ADMINISTRATION, OR Electric...

  10. New Issue: Moody's assigns Aa1 ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2015-C revenue bonds. Rating outlooks are stable. Global Credit Research - 23 Sep 2015 Approximately 110 million of debt securities affected BONNEVILLE POWER ADMINISTRATION, OR...

  11. Organizations' Assignment of Responsibility - DOE Directives,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Delegations, and Requirements

  12. Microsoft Word - CLP_Credit_Assignment_Table

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Units TRAININGEDUCATION Attendance at academic courses at an accredited college or ... (in relevant subject area or project management association) Active Membership ...

  13. Unclassified Foreign Visits and Assignments Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2010-10-14

    The order defines a program for unclassified foreign national access to DOE sites, information, technologies, and equipment. Supersedes DOE O 142.3.

  14. Preparing for Project Implementation Assigning Accountability...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for Each Project Save Energy Now LEADER Web Conference Project Implementation Seminar Series Save Energy Now LEADER Web Conference Agenda Seminar Series Overview ...

  15. TEPP - Exercise Evaluation Forms | Department of Energy

    Office of Environmental Management (EM)

    TEPP - Exercise Evaluation Forms TEPP - Exercise Evaluation Forms Hazardous Materials Exercise Evaluation Forms PDF icon Exercise Evaluation Forms More Documents & Publications...

  16. Detached rock evaluation device

    DOE Patents [OSTI]

    Hanson, David R.

    1986-01-01

    A rock detachment evaluation device (10) having an energy transducer unit 1) for sensing vibrations imparted to a subject rock (172) for converting the sensed vibrations into electrical signals, a low band pass filter unit (12) for receiving the electrical signal and transmitting only a low frequency segment thereof, a high band pass filter unit (13) for receiving the electrical signals and for transmitting only a high frequency segment thereof, a comparison unit (14) for receiving the low frequency and high frequency signals and for determining the difference in power between the signals, and a display unit (16) for displaying indicia of the difference, which provides a quantitative measure of rock detachment.

  17. A=20, 1998 evaluation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    20 (1998TI06) (Revised Manuscript from 1998) An evaluation of A = 20 was published in Nuclear Physics A636 (1998) p. 247. The version here lacks the introduction and overview tables that appeared in the full version, and is arranged in a different manner. The figures are present in this pdf document, and are available elsewhere on this server (see below). PDF HTML Figures A = 20 20n, 20He, 20Li, 20Be, 20B, 20C, 20N, 20O, 20F, 20Ne, 20Na, 20Mg, 20Al A = 20

  18. A=4, 1992 evaluation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 (1992TI02) (Revised Manuscript from 1992) An evaluation of A = 4 was published in Nuclear Physics A541 (1992) p. 1. The version here differs from the published version in that we have corrected a few errors discovered after the article went to press. Introduction and overview tables have been omitted from this manuscript. Reference key numbers have been changed to the NNDC/TUNL format. The figures are now present in the pdf document, and are also available elsewhere on this server (see below).

  19. Treatment Deployment Evaluation Tool

    SciTech Connect (OSTI)

    Rynearson, Michael Ardel; Plum, Martin Michael

    1999-08-01

    The U.S. Department of Energy (DOE) is responsible for the final disposition of legacy spent nuclear fuel (SNF). As a response, DOE's National Spent Nuclear Fuel Program (NSNFP) has been given the responsibility for the disposition of DOE -owned SNF. Many treatment technologies have been identified to treat some forms of SNF so that the resulting treated product is acceptable by the disposition site. One of these promising treatment processes is the electrometallurgical treatment (EMT) currently in development; a second is an Acid Wash Decladding process. The NSNFP has been tasked with identifying possible strategies for the deployment of these treatment processes in the event that the treatment path is deemed necessary. To support the siting studies of these strategies, economic evaluations are being performed to identify the least-cost deployment path. This model (tool) was developed to consider the full scope of costs, technical feasibility, process material disposition, and schedule attributes over the life of each deployment alternative. Using standard personal computer (PC) software, the model was developed as a comprehensive technology economic assessment tool using a Life-Cycle Cost (LCC) analysis methodology. Model development was planned as a systematic, iterative process of identifying and bounding the required activities to dispose of SNF. To support the evaluation process, activities are decomposed into lower level, easier to estimate activities. Sensitivity studies can then be performed on these activities, defining cost issues and testing results against the originally stated problem.

  20. Preliminary Process and Market Evaluation

    Broader source: Energy.gov [DOE]

    Preliminary Process and Market Evaluation, from a team of evaluators, independent of the BBNP program, with whom DOE contracted to assess the performance of BBNP and identify lessons learned.

  1. PAE Evaluation Portfolio Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Midge Smith Center for Evaluation Effectiveness, home of the Evaluators' Institute, and she is the Director of the PhD in Public Policy and Administration program, and Associate ...

  2. SECTION M_Evaluation Factors

    National Nuclear Security Administration (NNSA)

    EVALUATION OF PROPOSALS .....................................................................................2 M-2 BASIS FOR CONTRACT AWARD ...................................................................................3 M-3 TECHNICAL AND MANAGEMENT CRITERIA ..........................................................3 M-4 COST CRITERION .............................................................................................................6 Section M, Page 2 M-1 EVALUATION OF PROPOSALS

  3. NATIONAL EVALUATIONS: SUMMARY OF RESULTS

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EVALUATIONS: SUMMARY OF RESULTS DOE is pleased to summarize the results of two major national evaluations of the Weatherization Assistance Program (WAP or Weatherization). These evaluations were multiyear, peer-reviewed, statistically robust efforts led by Oak Ridge National Laboratory (ORNL). They are the most comprehensive, detailed analysis of the WAP and its operations ever conducted. The Retrospective Evaluation covers Program Year (PY) 2008 and is reflective of a typical year in WAP

  4. LIQUEFACTION EVALUATIONS AT DOE SITES

    Broader source: Energy.gov [DOE]

    Liquefaction Evaluations at DOE Sites M. Lewis, M. McHood, R. Williams, B. Gutierrez October 25, 2011

  5. Performance Evaluation and Measurement Plan

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ......... 4 PEMP ORGANIZATION Fee Determining Official ... Evaluation and Measurement Plan (PEMP) is an award fee plan containing both ...

  6. Exercise Controller and Evaluator Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1997-08-21

    This volume details the roles of controllers and evaluators in emergency exercises. Canceled by DOE G 151.1-3.

  7. APEEM Components Analysis and Evaluation

    Broader source: Energy.gov [DOE]

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  8. International Energy Program Evaluation Conference

    Broader source: Energy.gov [DOE]

    The International Energy Program Evaluation Conference (IEPEC) will be held in Long Beach, California, on Aug. 11-13, 2015.

  9. Evaluation of Abuse Tolerance Improvements

    Broader source: Energy.gov [DOE]

    2011 DOE Hydrogen and Fuel Cells Program, and Vehicle Technologies Program Annual Merit Review and Peer Evaluation

  10. Desalination technology evaluation

    SciTech Connect (OSTI)

    Del Bene, J.V.; Loh, G.T.; Schleicher, R.W.; Sgammato, T.A.; Sinha, A.K. )

    1992-12-01

    The shortage of potable water has hindered economic development in South Florida and other areas of the United States. This project, cosponsored with Florida Power Light (FPL), examines the economics of colocation of a water desalination plant with an electric power plant to take advantage of shared facilities, personnel, and equipments well as existing intake and outfall structures. In combination, these factors should reduce the cost of desalinated water. The first step in determining the viability of colocation is identification of desalination technologies best suited for dual-purpose applications in retrofits at existing fossil plants. Based on energy efficiency and commercial maturity, reverse osmosis (RO) and low-temperature multieffect distillation (LT-MED) technologies appear to be the best candidates for such application. In fact, RO provides the best economics for the plants and conditions studied. Of the emerging technologies evaluated, sodium molecular pumping and solvent extraction technologies should be further investigated for their potential in significantly reducing desalination costs.

  11. Evaluated teletherapy source library

    DOE Patents [OSTI]

    Cox, Lawrence J.; Schach Von Wittenau, Alexis E.

    2000-01-01

    The Evaluated Teletherapy Source Library (ETSL) is a system of hardware and software that provides for maintenance of a library of useful phase space descriptions (PSDs) of teletherapy sources used in radiation therapy for cancer treatment. The PSDs are designed to be used by PEREGRINE, the all-particle Monte Carlo dose calculation system. ETSL also stores other relevant information such as monitor unit factors (MUFs) for use with the PSDs, results of PEREGRINE calculations using the PSDs, clinical calibration measurements, and geometry descriptions sufficient for calculational purposes. Not all of this information is directly needed by PEREGRINE. It also is capable of acting as a repository for the Monte Carlo simulation history files from which the generic PSDs are derived.

  12. Standardized radiological dose evaluations

    SciTech Connect (OSTI)

    Peterson, V.L.; Stahlnecker, E.

    1996-05-01

    Following the end of the Cold War, the mission of Rocky Flats Environmental Technology Site changed from production of nuclear weapons to cleanup. Authorization baseis documents for the facilities, primarily the Final Safety Analysis Reports, are being replaced with new ones in which accident scenarios are sorted into coarse bins of consequence and frequency, similar to the approach of DOE-STD-3011-94. Because this binning does not require high precision, a standardized approach for radiological dose evaluations is taken for all the facilities at the site. This is done through a standard calculation ``template`` for use by all safety analysts preparing the new documents. This report describes this template and its use.

  13. Header design evaluation. Final report

    SciTech Connect (OSTI)

    Stubenhofer, R.L.

    1993-08-01

    An evaluation was conducted of two new six-pin header designs. This evaluation consisted of designing, evaluating, procuring, and building contact module subassemblies with each of the two designs. The study was initiated as a result of the high scrap costs associated with the current product design. Two new designs were found to be feasible alternative to the current design.

  14. A reevaluation of the assignment of the vibrational fundamentals and the rotational analysis of bands in the high-resolution infrared spectra of trans- and cis- 1,3,5-hexatriene

    SciTech Connect (OSTI)

    Craig, Norman C.; Leyden, Matthew C.; Moore, Michael C.; Patchen, Amie K.; van den Heuvel, Titus; Blake, Thomas A.; Masiello, Tony; Sams, Robert L.

    2010-07-01

    Assignments of the vibrational fundamentals of cis- and trans-1,3,5-hexatriene are reevaluated with new infrared and Raman spectra and with quantum chemical predictions of intensities and anharmonic frequencies. The rotational structure is analyzed in the high-resolution (0.0013-0.0018 cm -1) infrared spectra of three C-type bands of the trans isomer and two C-type bands of the cis isomer. The bands for the trans isomer are at 1010.96 cm-1 (v14), 900.908 cm-1 (v16), and 683.46 cm-1 (v17). Ground state (GS) rotational constants have been fitted to the combined ground state combination differences (GSCDs) for the three bands of the trans isomer. The bands for the cis isomer are at 907.70 cm-1 (v33) and 587.89 cm-1 (v35). GS rotational constants have been fitted to the combined GSCDs for the two bands of the cis isomer and compared with those obtained from microwave spectroscopy. Small inertial defects in the GSs confirm that both molecules are planar. Upper state rotational constants were fitted for all five bands.

  15. Ecological outcomes and evaluation of success in passively restored southeastern depressional wetlands.

    SciTech Connect (OSTI)

    De Steven, Diane; Sharitz, Rebecca R.; Barton, Christopher, D.

    2010-11-01

    Abstract: Depressional wetlands may be restored passively by disrupting prior drainage to recover original hydrology and relying on natural revegetation. Restored hydrology selects for wetland vegetation; however, depression geomorphology constrains the achievable hydroperiod, and plant communities are influenced by hydroperiod and available species pools. Such constraints can complicate assessments of restoration success. Sixteen drained depressions in South Carolina, USA, were restored experimentally by forest clearing and ditch plugging for potential crediting to a mitigation bank. Depressions were assigned to alternate revegetation methods representing desired targets of herbaceous and wet-forest communities. After five years, restoration progress and revegetation methods were evaluated. Restored hydroperiods differed among wetlands, but all sites developed diverse vegetation of native wetland species. Vegetation traits were influenced by hydroperiod and the effects of early drought, rather than by revegetation method. For mitigation banking, individual wetlands were assessed for improvement from pre-restoration condition and similarity to assigned reference type. Most wetlands met goals to increase hydroperiod, herb-species dominance, and wetland-plant composition. Fewer wetlands achieved equivalence to reference types because some vegetation targets were incompatible with depression hydroperiods and improbable without intensive management. The results illustrated a paradox in judging success when vegetation goals may be unsuited to system constraints.

  16. High Impact Technology HQ- Resources for Evaluators- Site Evaluation Checklists

    Office of Energy Efficiency and Renewable Energy (EERE)

    The HIT Catalyst conducts technology demonstrations in three main phases govern demonstrations: Site Evaluation, Selection and Project Kick-Off, Measurement and Verification Scoping and Plan...

  17. ARM - Evaluation Product - ARM Diagnostics for Climate Model Evaluation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ProductsARM Diagnostics for Climate Model Evaluation ARM Data Discovery Browse Data Documentation Use the Data File Inventory tool to view data availability at the file level. Comments? We would love to hear from you! Send us a note below or call us at 1-888-ARM-DATA. Send Evaluation Product : ARM Diagnostics for Climate Model Evaluation [ ARM research - evaluation data product ] This data products include two types of data sets: 1. Observational data: we use long-term continuous forcing data

  18. High Impact Technology Hub- Resources for Evaluators- Site Evaluation Checklists

    Broader source: Energy.gov [DOE]

    The HIT Catalyst conducts technology demonstrations in three main phases govern demonstrations: Site Evaluation, Selection and Project Kick-Off, Measurement and Verification Scoping and Plan...

  19. Rotary Microfilter Media Evaluation

    SciTech Connect (OSTI)

    Poirier, M

    2005-04-20

    Savannah River National Laboratory (SRNL) received funding from DOE EM-21, Office of Cleanup Technologies, to develop the rotary microfilter for high level radioactive service. One aspect of this project evaluated alternative filter media to select one for the 2nd generation rotary microfilter being procured as a prefilter to a small column ion exchange process. The authors conducted screening tests on a variety of filter media and pore sizes using a stirred cell followed by pilot-scale testing on a more limited number of filter media and pore sizes with a three disk rotary microfilter. These tests used 5.6 molar sodium supernate, and sludge plus monosodium titanate (MST) solids. The conclusions from this work are: (1) The 0.1 {micro} nominal TruMem{reg_sign} ceramic and the Pall PMM M050 (0.5 {micro} nominal) stainless steel filter media produced the highest flux in rotary filter testing. (2) The Pall PMM M050 media produced the highest flux of the stainless steel media tested in rotary filter testing. (3) The Pall PMM M050 media met filtrate quality requirements for the rotary filter. (4) The 0.1 {micro} TruMem{reg_sign} and 0.1 {micro} Pall PMM media met filtrate quality requirements as well. (5) The Pall PMM M050 media produced comparable flux to the 0.1 {micro} TruMem{reg_sign} media, and proved more durable and easier to weld. Based on these test results, the authors recommend Pall PMM M050 filter media for the 2nd generation rotary microfilter.

  20. RELAP5-3D Developmental Assessment: Comparison of Versions 4.0.3is and 2.4.2is

    SciTech Connect (OSTI)

    Paul D. Bayless

    2012-09-01

    Figures have been generated comparing the parameters used in the developmental assessment of the RELAP5-3D code using versions 4.0.3is and 2.4.2is. The figures, which are the same as those used in Volume III of the RELAP5-3D code manual, compare calculations using the semi-implicit solution scheme with available experiment data. These figures provide a quick, visual indication of how the code predictions changed between these two code versions and can be used to identify cases in which the assessment judgment may need to be changed in Volume III of the code manual. Changes to the assessment judgments made after reviewing all of the assessment cases are also provided.

  1. RELAP5-3D Developmental Assessment: Comparison of Versions 4.2.1i and 4.1.3i

    SciTech Connect (OSTI)

    Paul D. Bayless

    2014-06-01

    Figures have been generated comparing the parameters used in the developmental assessment of the RELAP5-3D code using versions 4.2.1i and 4.1.3i. The figures, which are the same as those used in Volume III of the RELAP5-3D code manual, compare calculations using the semi-implicit solution scheme with available experiment data. These figures provide a quick, visual indication of how the code predictions changed between these two code versions and can be used to identify cases in which the assessment judgment may need to be changed in Volume III of the code manual. Changes to the assessment judgments made after reviewing all of the assessment cases are also provided.

  2. RELAP5-3D Developmental Assessment: Comparison of Versions 4.3.4i and 4.2.1i

    SciTech Connect (OSTI)

    Bayless, Paul David

    2015-10-01

    Figures have been generated comparing the parameters used in the developmental assessment of the RELAP5-3D code using versions 4.3.4i and 4.2.1i. The figures, which are the same as those used in Volume III of the RELAP5-3D code manual, compare calculations using the semi-implicit solution scheme with available experiment data. These figures provide a quick, visual indication of how the code predictions changed between these two code versions and can be used to identify cases in which the assessment judgment may need to be changed in Volume III of the code manual. Changes to the assessment judgments made after reviewing all of the assessment cases are also provided.

  3. What happened after the evaluation?

    SciTech Connect (OSTI)

    Bennett, C L

    1999-03-12

    An ergonomics program including a ergonomic computer workstation evaluations at a research and development facility was assessed three years after formal implementation. As part of the assessment, 53 employees who had been subjects of computer workstation evaluations were interviewed. The documented reports (ergonomic evaluation forms) of the ergonomic evaluations were used in the process of selecting the interview subjects. The evaluation forms also provided information about the aspects of the computer workstation that were discussed and recommended as part of the evaluation, although the amount of detail and completeness of the forms varied. Although the results were mixed and reflective of the multivariate psychosocial factors affecting employees working in a large organization, the findings led to recommendations for improvements of the program.

  4. Hawaii-Okinawa Building Evaluations

    SciTech Connect (OSTI)

    Metzger, I.; Salasovich, J.

    2013-05-01

    NREL conducted energy evaluations at the Itoman City Hall building in Itoman, Okinawa Prefecture, Japan, and the Hawaii State Capitol building in Honolulu, Hawaii. This report summarizes the findings from the evaluations, including the best practices identified at each site and opportunities for improving energy efficiency and renewable energy. The findings from this evaluation are intended to inform energy efficient building design, energy efficiency technology, and management protocols for buildings in subtropical climates.

  5. State Energy Program Retrospective Evaluation

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of a major national evaluation of the State Energy Program (SEP), under the Office of Energy Efficiency and Renewable Energy. The Retrospective Evaluation of SEP's Program Year (PY) 2008, a typical year in SEP operations, was a multiyear, peer-reviewed, statistically robust effort led by Oak Ridge National Laboratory (ORNL). It is the most comprehensive, detailed analysis ever conducted of SEP. The purpose of the evaluation was to develop independent estimates of key program outcomes, including:

  6. State Energy Program National Evaluation

    Broader source: Energy.gov [DOE]

    The Weatherization and Intergovernmental Programs Office authorized the Oak Ridge National Laboratory to implement a national evaluation of the State Energy Program.

  7. Evaluating Rooftop Strength for PV

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power ... ActivitiesBalance of Systems and Soft CostsEvaluating Rooftop Strength for PV ...

  8. SECTION M_Evaluation Factors

    National Nuclear Security Administration (NNSA)

    the policies and procedures in Federal Acquisition Regulation (FAR) Part 15 and Department of Energy Acquisition Regulation (DEAR) Part 915. The Government will evaluate ...

  9. Compliance Evaluation | Department of Energy

    Office of Environmental Management (EM)

    Disposal Facility (SRR-CWDA-2009-00017, R0), hereafter referred to as the Saltstone PA, is acceptable. PDF icon Compliance Evaluation More Documents & Publications 2009...

  10. PAE Evaluation Portfolio Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Relatedly, the research community capable of conducting ... in the country in 2001 by the American Journal of Evaluation. ... a Ph.D. in Educational Psychology, Measurement and ...