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Sample records for detroit mi public

  1. ,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2014 ,"Release...

  2. DOE - Office of Legacy Management -- Dow-Detroit Edison Project - MI 0-02

    Office of Legacy Management (LM)

    Dow-Detroit Edison Project - MI 0-02 FUSRAP Considered Sites Site: Dow-Detroit Edison Project (MI.0-02 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Detroit , Michigan MI.0-02-1 Evaluation Year: 1987 MI.0-02-1 Site Operations: Performed reference design work for a special fast breeder type reactor. MI.0-02-1 Site Disposition: Eliminated - No radioactive material handled at the site MI.0-02-1 Radioactive Materials Handled: No

  3. Detroit Public Lighting Department - Commercial and Industrial...

    Broader source: Energy.gov (indexed) [DOE]

    PublicLightingEnergyWis... Expiration Date 11302012 State Michigan Program Type Rebate Program Rebate Amount Light Fixtures: 2-130 Lighting Controls: 0.10-65...

  4. Detroit, Michigan: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Detroit, Michigan: Energy Resources (Redirected from Detroit, MI) Jump to: navigation, search Equivalent URI DBpedia Coordinates 42.331427, -83.0457538 Show Map Loading map......

  5. City of Detroit- SmartBuildings Detroit Green Fund Loan

    Broader source: Energy.gov [DOE]

    The Economic Development Corporation (EDC) of the City of Detroit is offering financial assistance to commercial, institutional and public buildings in Detroit that install energy efficiency and ...

  6. Secretary Moniz Applauds Detroit's LED Street Lighting Upgrades...

    Broader source: Energy.gov (indexed) [DOE]

    an update of its largely broken public lighting system, speaking at the Detroit Area ... The Detroit street lighting project includes the participation of the Energy Department, ...

  7. Detroit Workshop Highlights

    Broader source: Energy.gov [DOE]

    View the video showing highlights from the ninth annual DOE Solid-State Lighting Market Development Workshop in Detroit.

  8. American Recovery and Reinvestment Act ( ARRA) FEMP Technical Assistance, U.S. General Services Administration - Project 194 U.S. Custom Cargo Inspection Facility, Detroit, MI

    SciTech Connect (OSTI)

    Arends, J.; Sandusky, William F.

    2010-05-31

    This report documents the findings of an on-site audit of the U.S. Customs Cargo Inspection Facility (CIF) in Detroit, Michigan. The federal landlord for this building is the General Services Administration (GSA). The focus of the audit was to identify various no-cost or low-cost energy-efficiency opportunities that, once implemented, would reduce electrical and gas consumption and increase the operational efficiency of the building. This audit also provided an opportunity to identify potential capital cost projects that should be considered in the future to acquire additional energy (electric and gas) and water savings to further increase the operational efficiency of the building.

  9. Restoring Detroit's Street Lighting System

    SciTech Connect (OSTI)

    Kinzey, Bruce R.

    2015-10-21

    The City of Detroit is undertaking a comprehensive restoration of its street lighting system that includes transitioning the existing high-pressure sodium (HPS) sources to light-emitting diode (LED). Detroit’s well-publicized financial troubles over the last several years have added many hurdles and constraints to this process. Strategies to overcome these issues have largely been successful, but have also brought some mixed results. This document provides an objective review of the circumstances surrounding the system restoration, the processes undertaken and decisions made, and the results so far.

  10. SEP Success Story: Detroit Diesel

    Broader source: Energy.gov [DOE]

    This video features Detroit Diesel’s success with DOE’s Superior Energy Performance® (SEP™) program. Daimler’s Detroit Diesel Corporation facility earned Platinum SEP certification in November 2015...

  11. Detroit, MI Natural Gas Exports to Canada

    Gasoline and Diesel Fuel Update (EIA)

    2009 2010 2011 2012 2013 2014 View History Pipeline Volumes 21 79 19 0 165 188 1996-2014 Pipeline Prices 4.53 8.37 5.17 -- 4.44 5.26 1996...

  12. Detroit, MI Natural Gas Exports to Canada

    Gasoline and Diesel Fuel Update (EIA)

    275 43,690 50,347 50,439 46,981 37,528 1996-2015 Pipeline Prices 4.69 4.26 3.10 4.04 5.36 2.91

  13. Ricardo Detroit Technical Center | Open Energy Information

    Open Energy Info (EERE)

    Ricardo Detroit Technical Center Jump to: navigation, search Name: Ricardo Detroit Technical Center Place: Van Buren Township, Michigan Zip: 48111-1641 Sector: Services Product:...

  14. Detroit Auto Show 2012 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Detroit Auto Show 2012 Detroit Auto Show 2012 Addthis 1 of 10 Energy Secretary Steven Chu with Chrysler Chief Executive Sergio Marchionne. Image: Hantz Leger (Energy Department ...

  15. Detroit Commuter Hydrogen Project

    SciTech Connect (OSTI)

    Brooks, Jerry; Prebo, Brendan

    2010-07-31

    This project was undertaken to demonstrate the viability of using hydrogen as a fuel in an internal combustion engine vehicle for use as a part of a mass transit system. The advantages of hydrogen as a fuel include renew-ability, minimal environmental impact on air quality and the environment, and potential to reduce dependence on foreign energy sources for the transportation sector. Recognizing the potential for the hydrogen fuel concept, the Southeast Michigan Congress of Governments (SEMCOG) determined to consider it in the study of a proposed regional mass transit rail system for southeast Michigan. SEMCOG wanted to evaluate the feasibility of using hydrogen fueled internal combustion engine (H2ICE) vehicles in shuttle buses to connect the Detroit Metro Airport to a proposed, nearby rail station. Shuttle buses are in current use on the airport for passenger parking and inter-terminal transport. This duty cycle is well suited to the application of hydrogen fuel at this time because of the ability to re-fuel vehicles at a single nearby facility, overcoming the challenge of restricted fuel availability in the undeveloped hydrogen fuel infrastructure. A cooperative agreement between SEMCOG and the DOE was initiated and two H2ICE buses were placed in regular passenger service on March 29, 2009 and operated for six months in regular passenger service. The buses were developed and built by the Ford Motor Company. Wayne County Airport Authority provided the location for the demonstration with the airport transportation contractor, Metro Cars Inc. operating the buses. The buses were built on Ford E450 chassis and incorporated a modified a 6.8L V-10 engine with specially designed supercharger, fuel rails and injectors among other sophisticated control systems. Up to 30 kg of on-board gaseous hydrogen were stored in a modular six tank, 350 bar (5000 psi) system to provide a 150 mile driving range. The bus chassis and body were configured to carry nine passengers with

  16. TEXT-ALTERNATIVE VERSION: DETROIT WORKSHOP HIGHLIGHTS

    Broader source: Energy.gov [DOE]

    Mayor Mike Duggan, City of Detroit: The DOE has just been an outstanding partner, and I'm really glad to be welcoming you here at this time. So welcome to Detroit.

  17. Post Mortem of 120k mi Light-Duty Urea SCR and DPF System | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Post Mortem of 120k mi Light-Duty Urea SCR and DPF System Post Mortem of 120k mi Light-Duty Urea SCR and DPF System Presentation given at the 2007 Diesel Engine-Efficiency & Emissions Research Conference (DEER 2007). 13-16 August, 2007, Detroit, Michigan. Sponsored by the U.S. Department of Energy's (DOE) Office of FreedomCAR and Vehicle Technologies (OFCVT). deer07_lambert.pdf (649.68 KB) More Documents & Publications Urea SCR and DPF System for Tier 2 Diesel Light-Duty

  18. DOE - Office of Legacy Management -- Wolverine Tube Division - MI 05

    Office of Legacy Management (LM)

    Wolverine Tube Division - MI 05 FUSRAP Considered Sites Site: Wolverine Tube Division (MI.05) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Wolverine Tube Division of Calumet & Hecla Consolidated Copper Co. Star Tool Hermes Automotive Manufacturing Corporation MI.05-1 MI.05-2 Location: 1411 Central Avenue , Detroit , Michigan MI.05-3 Evaluation Year: 1990 MI.05-2 Site Operations: 1943 - Conducted research and development of methods for spinning

  19. DOE - Office of Legacy Management -- Detrex Corp - MI 10

    Office of Legacy Management (LM)

    Detrex Corp - MI 10 FUSRAP Considered Sites Site: Detrex Corp. (MI.10 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Detroit , Michigan MI.10-1 Evaluation Year: 1987 MI.10-2 Site Operations: Conducted experimental runs relative to pickling/degreasing of one handful of uranium turnings MI.10-1 Site Disposition: Eliminated - Potential for contamination considered remote due to small quantity of material handled - There is no

  20. Detroit, Michigan: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Detroit, Michigan: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 42.331427, -83.0457538 Show Map Loading map... "minzoom":false,"mappingservi...

  1. Restoring Detroits Street Lighting System

    Energy Savers [EERE]

    Restoring Detroit's Street Lighting System September 2015 Bruce Kinzey PNNL- 24692 Restoring Detroit's Street Lighting System Bruce Kinzey September 2015 Prepared ...

  2. City of Detroit Lakes, Minnesota (Utility Company) | Open Energy...

    Open Energy Info (EERE)

    Lakes, Minnesota (Utility Company) Jump to: navigation, search Name: City of Detroit Lakes Place: Minnesota Website: www.ci.detroit-lakes.mn.usmai Facebook: https:...

  3. City of Detroit (Michigan) EIA Revenue and Sales - February 2008...

    Open Energy Info (EERE)

    City of Detroit (Michigan) EIA Revenue and Sales - February 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for February...

  4. City of Detroit (Michigan) EIA Revenue and Sales - May 2008 ...

    Open Energy Info (EERE)

    Detroit (Michigan) EIA Revenue and Sales - May 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for May 2008. Monthly...

  5. City of Detroit (Michigan) EIA Revenue and Sales - February 2009...

    Open Energy Info (EERE)

    City of Detroit for February 2009. Monthly Electric Utility Sales and Revenue Data Short Name 2009-02 Utility Company City of Detroit (Michigan) Place Michigan Start Date...

  6. City of Detroit (Michigan) EIA Revenue and Sales - November 2008...

    Open Energy Info (EERE)

    City of Detroit (Michigan) EIA Revenue and Sales - November 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for November...

  7. City of Detroit (Michigan) EIA Revenue and Sales - December 2008...

    Open Energy Info (EERE)

    City of Detroit for December 2008. Monthly Electric Utility Sales and Revenue Data Short Name 2008-12 Utility Company City of Detroit (Michigan) Place Michigan Start Date...

  8. PP-221 Detroit Edison Company | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Permit authorizing Detroit Edison Company to construct, operate and maintain electric transmission facilities at the U.S. - Canada border. PDF icon PP-221 Detroit.pdf More ...

  9. DOE - Office of Legacy Management -- Carboloy Co - MI 12

    Office of Legacy Management (LM)

    Carboloy Co - MI 12 FUSRAP Considered Sites Site: Carboloy Co. (MI.12 ) Eliminated from further consideration under FUSRAP - AEC licensed facility Designated Name: Not Designated Alternate Name: General Electric MI.12-1 Location: 11177 E. Eight Mile Road , Detroit , Michigan MI.12-1 MI.12-2 Evaluation Year: 1987-1991 MI.12-3 MI.12-4 MI.12-6 Site Operations: Turned-down the outer diameter of uranium metal slugs and conducted pilot plant scale operations for hot pressing uranium dioxide pellets

  10. SEP Case Study Webinar: Detroit Diesel Slides

    Broader source: Energy.gov [DOE]

    This page contains the presentation slides from the Superior Energy Performance (SEP) Measurement and Verification Case Study webinar on Detroit Diesel hosted on July 14, 2016. This webinar...

  11. SmartBuildings Detroit Commercial Case Study

    Broader source: Energy.gov [DOE]

    SmartBuildings Detroit Commercial Case Study, a document from BetterBuildings for Michigan posted on the website of the U.S. Department of Energy's Better Buildings Neighborhood Program.

  12. Detroit, MI Natural Gas Imports by Pipeline from Canada

    Gasoline and Diesel Fuel Update (EIA)

    2009 2010 2011 2012 2013 2014 View History Pipeline Volumes 21 79 19 0 165 188 1996-2014 Pipeline Prices 4.53 8.37 5.17 -- 4.44 5.26 1996-2014

  13. A Look Inside the Detroit Auto Show | Department of Energy

    Energy Savers [EERE]

    the Detroit Auto Show A Look Inside the Detroit Auto Show January 12, 2011 - 1:15pm Addthis Kerry Duggan Kerry Duggan Waking up at 4:30AM is not my idea of fun. But after I ...

  14. City of Detroit (Michigan) EIA Revenue and Sales - June 2008...

    Open Energy Info (EERE)

    City of Detroit for June 2008. Monthly Electric Utility Sales and Revenue Data Short Name 2008-06 Utility Company City of Detroit (Michigan) Place Michigan Start Date 2008-06-01...

  15. City of Detroit (Michigan) EIA Revenue and Sales - August 2008...

    Open Energy Info (EERE)

    City of Detroit for August 2008. Monthly Electric Utility Sales and Revenue Data Short Name 2008-08 Utility Company City of Detroit (Michigan) Place Michigan Start Date 2008-08-01...

  16. DOE - Office of Legacy Management -- Revere Copper and Brass Co - MI 04

    Office of Legacy Management (LM)

    Revere Copper and Brass Co - MI 04 FUSRAP Considered Sites Site: REVERE COPPER AND BRASS CO. ( MI.04 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Revere Copper and Brass MI.04-1 Location: 5851 West Jefferson Street , Detroit , Michigan MI.04-1 Evaluation Year: 1990 MI.04-2 Site Operations: Extrusion of tuballoy rods, myrnalloy rods and beryllium shapes in the 1940s. MI.04-3 MI.04-4 Site Disposition: Eliminated - Radiation levels below criteria

  17. Detroit Beach, Michigan: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Detroit Beach, Michigan: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 41.9311563, -83.3268753 Show Map Loading map... "minzoom":false,"mappi...

  18. City of Detroit (Michigan) EIA Revenue and Sales - January 2009...

    Open Energy Info (EERE)

    January 2009 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for January 2009. Monthly Electric Utility Sales and Revenue Data...

  19. City of Detroit (Michigan) EIA Revenue and Sales - January 2008...

    Open Energy Info (EERE)

    January 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for January 2008. Monthly Electric Utility Sales and Revenue Data...

  20. Detroit Edison Advanced Implementation of Energy Storage Technologies

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Storage Technologies Project Description Detroit Edison will complete installation and begin an aggregated 1 MW Community Energy Storage (CES) System in their ...

  1. The Detroit Edison Company Smart Grid Demonstration Project ...

    Open Energy Info (EERE)

    based in Detroit, Michigan. Overview Demonstrate the use and benefits of Community Energy Storage (CES) systems for utilities and test the ability to integrate secondary-use...

  2. City of Detroit (Michigan) EIA Revenue and Sales - July 2008...

    Open Energy Info (EERE)

    July 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for July 2008. Monthly Electric Utility Sales and Revenue Data Short...

  3. City of Detroit (Michigan) EIA Revenue and Sales - March 2009...

    Open Energy Info (EERE)

    9 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for March 2009. Monthly Electric Utility Sales and Revenue Data Short Name...

  4. City of Detroit (Michigan) EIA Revenue and Sales - March 2008...

    Open Energy Info (EERE)

    March 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for March 2008. Monthly Electric Utility Sales and Revenue Data Short...

  5. City of Detroit (Michigan) EIA Revenue and Sales - April 2008...

    Open Energy Info (EERE)

    April 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for April 2008. Monthly Electric Utility Sales and Revenue Data Short...

  6. Superior Energy Performance Webinar: Detroit Diesel SEP Success, July 14,

    Energy Savers [EERE]

    2PM eastern time | Department of Energy Webinar: Detroit Diesel SEP Success, July 14, 2PM eastern time Superior Energy Performance Webinar: Detroit Diesel SEP Success, July 14, 2PM eastern time July 6, 2016 - 2:13pm Addthis The DOE Advanced Manufacturing Office (AMO) is pleased to announce the fourth webinar in its series highlighting U.S. manufacturing facilities that have achieved Superior Energy Performance (SEP) certification. These facilities have fully implemented the ISO 50001

  7. Health-hazard evaluation report HETA 84-484-1754, Detroit Fire Fighters, Detroit, Michigan

    SciTech Connect (OSTI)

    Anderson, K.E.; Melius, J.M.

    1986-12-01

    In response to a request from the International Association of Fire Fighters on behalf of the Detroit Fire Fighters Association, Detroit, Michigan, a health hazard evaluation was made of respiratory symptoms and skin irritation in fire fighters involved in a large fire and explosion at a warehouse. Over 200 fire fighters from fire-fighting organizations in three communities were involved in the incident. Site runoff water contained chlordane and malathion in low parts per million; other samples were negative. Nose and throat irritation, cough, and shortness of breath were experienced by a large proportion of fire fighters following the fire, and in 14, 15, and 17 percent, respectively, symptoms persisted over 2 months. Symptoms were significantly associated with time spent at the scene and time spent in heavy smoke. Pulmonary function tests were abnormal in 14 cases, ten due to obstructive lung disease, three to restrictive lung disease, and one to a combination. The authors conclude that better protective equipment is needed for fire fighters at chemical fires. Recommendations include development of a hazardous-materials response team, and implementation of a routine medical surveillance program.

  8. The Office of Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95-619), dated November 9, 1978

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95- 619), dated November 9, 1978. The following is MI's legislative mandate. PART 3 - - MINORITY ECONOMIC IMPACT SEC. 641. MINORITY ECONOMIC IMPACT. "(a) Establishment of Office of Minority Economic Impact -- Title II of the Department of Energy Organization Act (42 U.S.C. 7131 - - 7139) is amended by adding at the end thereof

  9. Detroit, MI Natural Gas Pipeline Exports to Canada (Dollars per Thousand

    U.S. Energy Information Administration (EIA) Indexed Site

    Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.36 2.55 2.26 2.30 2000's 3.74 4.57 3.03 5.47 6.47 8.12 7.61 6.88 8.37 4.01 2010's 4.69 4.26 3.10 4.04 5.36 2.9

  10. Detroit, MI Natural Gas Pipeline Exports to Canada (Dollars per Thousand

    U.S. Energy Information Administration (EIA) Indexed Site

    Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.72 4.58 4.22 4.51 4.66 4.73 4.55 4.45 4.19 3.92 3.79 3.60 2012 3.14 2.95 2.61 2.33 2.50 2.62 3.08 3.12 2.99 3.41 4.13 3.90 2013 4.04 3.67 3.96 4.42 4.42 4.26 4.02 3.84 3.90 3.89 3.79 4.34 2014 5.67 10.21 7.89 4.89 4.93 4.86 4.44 4.06 4.14 4.11 4.20 4.16 2015 3.38 3.80 3.19 2.77 2.78 2.94 2.97 3.07 2.91 2.71 2.22 2.24 2016 2.50 2.25 1.86 1.92 1.91 2.3

  11. Detroit, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 30,410 31,080 24,908 25,049 2000's 36,007 35,644 7,431 19,737 40,030 40,255 22,156 22,904 27,220 43,980 2010's 44,275 43,690 50,347 50,439 46,981 37,528

  12. Detroit, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 3,465 2,693 3,676 3,988 3,357 3,437 765 3,916 4,318 4,473 4,851 4,752 2012 5,562 5,372 5,253 3,745 3,354 2,811 2,935 3,822 4,015 4,113 4,636 4,728 2013 4,791 4,331 4,801 3,571 4,430 3,769 3,933 4,131 3,885 2,862 3,886 4,945 2014 4,042 4,259 4,171 3,540 3,852 4,008 3,643 3,461 3,414 4,013 3,800 4,779 2015 3,753 2,420 4,176 2,416 2,035 1,911 2,624 2,674 4,755 4,944 3,048 2,773 2016 2,881 2,701 3,427 1,402 1,301 2,806

  13. Detroit, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand

    U.S. Energy Information Administration (EIA) Indexed Site

    Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.75 2.51 2.43 2.51 2000's 3.82 9.34 3.56 5.96 6.27 -- -- 8.28 6.58 4.53 2010's 8.37 5.17 -- 4.4

  14. Detroit, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand

    U.S. Energy Information Administration (EIA) Indexed Site

    Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.95 5.33 2013 3.80 4.50 4.09 4.63 201

  15. Detroit, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 14,901 11,501 10,925 7,671 2000's 6,171 405 1,948 2,514 1,117 0 0 81 753 21 2010's 79 19 0 165

  16. Detroit, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 8 11 2013 16 140 24 10 2014

  17. Detroit, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)

    Gasoline and Diesel Fuel Update (EIA)

    Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.36 2.55 2.26 2.30 2000's 3.74 4.57 3.03 5.47 6.47 8.12 7.61 6.88 8.37 4.01 2010's 4.69 4.26 3.10 4.04 5.36 2.9 Cubic Feet)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.72 4.58 4.22 4.51 4.66 4.73 4.55 4.45 4.19 3.92 3.79 3.60 2012 3.14 2.95 2.61 2.33 2.50 2.62 3.08 3.12 2.99 3.41 4.13 3.90 2013 4.04 3.67 3.96 4.42 4.42 4.26 4.02 3.84 3.90 3.89 3.79 4.34 2014 5.67 10.21 7.89

  18. Detroit, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    Gasoline and Diesel Fuel Update (EIA)

    Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.75 2.51 2.43 2.51 2000's 3.82 9.34 3.56 5.96 6.27 -- -- 8.28 6.58 4.53 2010's 8.37 5.17 -- 4.4 Cubic Feet)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.95 5.33 2013 3.80 4.50 4.09 4.63 201

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 8 11 2013 16 140 24 10 2014

  19. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    publications Publications JLF Science Publications JLF Facility-related Publications JLF Highlights

  20. Detroit Edison's Fermi 1 - Preparation for Reactor Removal

    SciTech Connect (OSTI)

    Swindle, Danny [Sargent and Lundy Engineers, LLC, 55 E. Monroe Street, Chicago, IL 60603 (United States)

    2008-01-15

    This paper is intended to provide information about the ongoing decommissioning tasks at Detroit Edison's Fermi 1 plant, and in particular, the work being performed to prepare the reactor for removal and disposal. In 1972 Fermi 1 was shutdown and the fuel returned to the Atomic Energy Commission. By the end of 1975, a retirement plan was prepared, the bulk sodium removed, and the plant placed in a safe store condition. The plant systems were left isolated with the sodium containing systems inert with carbon dioxide in an attempt to form a carbonate layer, thus passivating the underlying reactive sodium. In 1996, Detroit Edison determined to evaluate the condition of the plant and to make recommendations in relation to the Fermi 1 future plans. At the end of 1997 approval was obtained to remove the bulk asbestos and residual alkali-metals (i.e., sodium and sodium potassium (NaK)). In 2000, full nuclear decommissioning of the plant was approved. To date, the bulk asbestos insulation has been removed, and the only NaK remaining is located in six capillary instrument tubes. The remaining sodium is contained within the reactor, two of the three primary loops, and miscellaneous removed pipes and equipment to be processed. The preferred method for removing or reacting sodium at Fermi 1 is by injecting superheated steam into a heated, nitrogen inert system. The byproducts of this reaction are caustic sodium hydroxide, hydrogen gas, and heat. The decision was made to separate the three primary loops from the reactor for better control prior to processing each loop and the reactor separately. The first loop has already been processed. The main focus is now to process the reactor to allow removal and disposal of the Class C waste prior to the anticipated June 2008 closure of the Barnwell radioactive waste disposal facility located in South Carolina. Lessons learnt are summarized and concern: the realistic schedule and adherence to the schedule, time estimates, personnel

  1. Measurement of the direct <mi>CP> -violating parameter <mi>Ami><mi>CP> in the decay <mi>D>+<mi>Kmi>-<mimi>+<mi>π>+

    SciTech Connect (OSTI)

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.

    2014-12-01

    We measure the direct mi>Cmi>mi>P>-violating parameter mi>Ami>mi>Cmi>mi>Pmi> for the decay of the charged charm meson, mi>Dmi>+mi>Kmi>-mi>πmi>+mi>πmi>+ (and charge conjugate), using the full 10.4 mi>fbmi>-1 sample of mi>p>mi>p>¯ collisions at mi>smi>=1.96 mi>TeVmi> collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from mi>B>mi>D

  2. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    work. Today at Berkeley Lab: : The daily newsletter for our employees and collaborators. Publications.lbl.gov: : Over 75,000 of our laboratory's scientific publications,...

  3. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publications Engineering Institute Publications Publications are organized by topic. Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Model Verification and Validation Sensor and Sensing Technologies Structural Health Monitoring Earthquake Engineering and Structural Dynamics Damage Prognosis Other Publications Book

  4. Selected Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    publications

  5. Selected Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    publications /

  6. MINOS Experiment and NuMI Beam Home Page

    Broader source: All U.S. Department of Energy (DOE) Office Webpages

    NuMI-MINOS Neutrino Logo NuMI Beamline and MINOS Experiment Neutrino Logo The MINOS Experiment and NuMI Beamline Fermilab Logo MINOS Experiment Links ◊ MINOS for the Public ◊ Scientific Results ◊ MINOS at Work ◊ NuMI at Work ◊ MINOS+ Experiment Fermilab Neutrino Links ◊ Neutrino FAQ ◊ MINOS Underground Areas at Fermilab ◊ PPD Intensity Frontier Dept Back to - - - ◊ Fermilab at Work ◊ Fermilab Home the MINOS Far Detector in the Soudan Mine MINOS collaborators assembling the

  7. Rotary engine design: Analysis and developments; Proceedings of the International Congress and Exposition, Detroit, MI, Feb. 27-Mar. 3, 1989

    SciTech Connect (OSTI)

    Not Available

    1989-01-01

    The present conference on the development status of Wankel cycle rotary engine design discusses stratified-charge rotary engine features, techniques for noise and vibration reduction in rotary engines, testing methods for insulated rotary engine components, cyclic combustion variation in rotary engines, and a combustion model for homogeneous charge natural gas rotary engines. Also discussed are fuel-air mixing and distribution in a direct-injection stratified-charge rotary engine, the 'rotary-vee' engine design concept, strain measurements in a rotary engine housing, and a comparison of computed and measured pressure in a premixed-charge natural gas-fueled rotary engine.

  8. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publications Proud Legacy, Bold Future, Since 1943 Publications Los Alamos publications demonstrate the Lab's enduring commitment to researching and applying the best science, engineering and technology in order to meet the challenges facing our country and society in the 21st century. NEW ISSUE: 1663 JULY 2016 July 2016 The Brief Lives of Neutrons Turmoil at the Top of the World Not Magic...Quantum Breaking the Bond Ripples in Space and Time Small Fusion Could be Huge Muon Mission in Tuscany

  9. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publications Publications Official releases of Richard P. Feynman Center for Innovation publications General Inquiries Richard P. Feynman Center for Innovation (505) 665-9090 Email All years denote Fiscal Years. Progress Report FY14 FCI Progress Report 2014 (pdf) 2013 (pdf) 2011-2012 (pdf) 2009-2010 (pdf) 2007-2008 (pdf) 2005-2006 (pdf) 2004 (pdf) outSTANDING innOVATION Awards After 2011, the outSTANDING innOVATION Awards booklet and Progress Report were combined into a single publication. FY11

  10. DTE Energy Technologies With Detroit Edison Co. and Kinectrics Inc.: Distributed Resources Aggregation Modeling and Field Configuration Testing

    SciTech Connect (OSTI)

    Not Available

    2003-10-01

    Summarizes the work of DTE Energy Technologies, Detroit Edison, and Kinectrics, under contract to DOE's Distribution and Interconnection R&D, to develop distributed resources aggregation modeling and field configuration testing.

  11. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GCPCC's collaboration and publication policy Beamline acknowledgement Publication List Please contact us when you have a publication resulting from work done at the GCPCC PX beamline. Miller MD, Phillips GN Jr., White MA, Fox RO, Craft BC III The development of the GCPCC Protein Crystallography Beamline at CAMD. Application of Accelerators in Research and Industry -- Sixteenth Int'l Conf., J.L. Duggan and I.L. Morgan eds., 734-737 (2001). {PDF} Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R,

  12. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Book Chapters and Other Publications Book Chapters and Other Publications Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Book Chapters C. J. Stull, F. M. Hemez and C. R. Farrar, "On Assessing the Robustness of Structural Health Monitoring Technologies," Topics in Model Validation and Uncertainty

  13. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Model Verification and Validation Model Verification and Validation Publications Publications are organized by topic. Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Jutta Kayser (505) 663-5649 Email Administrative Assistant Stacy Baker (505) 663-5233 Email Decision-Making for Science-Based Predictive Modeling Atamturktur, H.S., Egeberg, M.C., Hemez, F.M., Stevens, G.N., "Defining Coverage of an

  14. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structural Health Monitoring Structural Health Monitoring Publications Publications are organized by topic. Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Structural Health Monitoring is the process of implementing a damage detection strategy for aerospace, civil and mechanical engineering infrastructure is referred

  15. Daimler's Detroit Diesel Plant Earns Superior Energy Performance, Saves

    Energy Savers [EERE]

    Safety and Security Reform Meeting DOE Safety and Security Reform Meeting Meeting Date: August 13, 2010 HSS senior managers with lead responsibilities in DOE's safety and security reform activities met with labor union representatives to discuss approach and process for the engagement of worker stakeholders in the reform efforts. Documents Available for Download Meeting Agenda (74.42 KB) Meeting Summary (95.69 KB) More Documents & Publications Work Group Telecom (Draft Charters) Focus Group

  16. Advanced Communication and Control of Distributed Energy Resources at Detroit Edison

    SciTech Connect (OSTI)

    Haukur Asgeirsson; Richard Seguin

    2004-01-31

    The project objective was to create the communication and control system, the process and the economic procedures that will allow owners (e.g., residential, commercial, industrial, manufacturing, etc.) of Distributed Energy Resources (DER) connected in parallel to the electric distribution to have their resources operated in a manner that protects the electric utility distribution network and personnel that may be working on the network. The Distribution Engineering Workstation (DEW) (a power flow and short circuit modeling tool) was modified to calculate the real-time characteristics of the distribution network based on the real-time electric distribution network information and provide DER operating suggestions to the Detroit Edison system operators so that regional electric stability is maintained. Part of the suggestion algorithm takes into account the operational availability of DERs, which is known by the Energy Aggregator, DTE Energy Technologies. The availability information will be exchanged from DTE Energy Technologies to Detroit Edison. For the calculated suggestions to be used by the Detroit Edison operators, procedures were developed to allow an operator to operate a DER by requesting operation of the DER through DTE Energy Technologies. Prior to issuing control of a DER, the safety of the distribution network and personnel needs to be taken into account. This information will be exchanged from Detroit Edison to DTE Energy Technologies. Once it is safe to control the DER, DTE Energy Technologies will issue the control signal. The real-time monitoring of the DECo system will reflect the DER control. Multi-vendor DER technologies representing approximately 4 MW of capacity was monitored and controlled using a web-based communication path. The DER technologies included are a photovoltaic system, energy storage, fuel cells and natural gas/diesel internal combustion engine generators. This report documents Phase I result for the Detroit Edison (Utility

  17. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Damage Prognosis Publications-Damage Prognosis Journal articles for the topic Damage Prognosis. Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Journal articles Gabbatto, M., Conte, J, Kosmatka, J. Farrar, C. R., "Reliability-Based Framework for Fatigue Damage Prognosis of Composite Aircraft Structures,"

  18. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Earthquake Engineering and Structural Dynamics Earthquake Engineering and Structural Dynamics Publications Journal articles are organized by date. Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Journal articles D. Mascarenas, D. Macknelly, J. Mullins, H. Wiest and G. Park, "Dynamic characterization of satellite

  19. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Los Alamos Reports Los Alamos Reports Unless identified as SRD (Secret Restricted Data), these reports are available to the public from the National Technical Information Service, Springfield, VA. Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Los Alamos Reports E. Figueiredo, G. Park, J. Figueiras, C. R. Farrar,

  20. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sensors and Sensing Technologies Sensors and Sensing Technologies Publications Journal articles on Sensors and Sensing Technologies Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Journal Articles Stull, C.J., Taylor, S. G., Wren, J., Mascarenas, D.L., Farrar, C. R., "Real-Time Condition Assessment of the Raptor

  1. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Directed Organization of Functional Materials at Inorganic-Macromolecular Interfaces Recent Publications R. Tunuguntla, M. Bangar, K. Kim, P. Stroeve, C.M. Ajo-Franklin, A. Noy, "Lipid Bilayer Composition can Influence the Orientation of Proteorhodopsin in Artificial Membranes", Biophys. J., accepted (2013) A. Noy "Kinetic model of gas transport in carbon nanotube channels", The Journal of Physical Chemistry C 117, 7656 (2013) A. Noy, R.W. Friddle "Practical single

  2. Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fundamental Mechanisms of Transient States in Materials Quantified by DTEM Recent Publications N.D. Browning, M.A. Bonds, G.H. Campbell, J.E. Evans, T. LaGrange, K.L. Jungjohann, D.J. Masiel, J. McKeown, S. Mehraen, B.W. Reed, M. Santala, "Recent Developments in Dynamic Transmission Electron Microscopy," Current Opinion in Solid State and Materials Science, 16 [1] 23 - 30 (2012). Thomas LaGrange, Bryan W. Reed, Melissa Santala, Joseph McKeown, Andreas Kulovits, Jörg M. K. Wiezorek,

  3. Evaluation of Fish Passage Conditions for Juvenile Salmonids Using Sensor Fish at Detroit Dam, Oregon

    SciTech Connect (OSTI)

    Duncan, Joanne P.

    2010-01-29

    Fish passage conditions through two spillways at Detroit Dam on the North Santiam River in Oregon were evaluated by Pacific Northwest National Laboratory for the U.S. Army Corps of Engineers (USACE), Portland District, using Sensor Fish devices. The objective of the study was to describe and compare passage exposure conditions through Spillbay 3 and Spillbay 6 at 1.5- and 3.5-ft gate openings, identifying potential fish injury regions of the routes. The study was performed in July 2009, concurrent with HI-Z balloon-tag studies by Normandeau Associates, Inc. Sensor Fish and live fish were deployed at elevations approximately 3 ft above structure at depths determined using a computational fluid dynamics model. Data collected were analyzed to estimate 1) exposure conditions, particularly exposure to severe collision and shear events by passage route sub-regions; 2) differences in passage conditions between passage routes; and 3) relationships to live-fish injury and mortality data estimates.

  4. Coal-water-slurry autoignition in a high-speed Detroit diesel engine

    SciTech Connect (OSTI)

    Schwalb, J.A.; Ryan, T.W. III.; Kakwani, R.M.; Winsor, R.E.

    1994-10-01

    Autoignition of coal-water-slurry (CWS) fuel in a two-stroke engine operating at 1900 RPM has been achieved. A Pump-Line-Nozzle (PLN) injection system, delivering 400mm{sup 3} injection of CWS, was installed in one modified cylinder of a Detroit Diesel Corporation (DDC) 8V-149TI engine, while the other seven cylinders remained configured for diesel fuel. Coal Combustion was sustained by maintaining high gas and surface temperatures with a combination of hot residual gases, warm inlet air admission, ceramic insulated components and increased compression ratio. The coal-fueled cylinder generated 85kW indicated power (80 percent of rated power), and lower NO{sub x} levels with a combustion efficiency of 99.2 percent. 6 refs., 15 figs., 4 tabs.

  5. Field Demonstration of a 24-kV Superconducting Cable at Detroit Edison

    SciTech Connect (OSTI)

    Kelley, Nathan; Corsaro, Pietro

    2004-12-01

    Customer acceptance of high temperature superconducting (HTS) cable technology requires a substantial field demonstration illustrating both the system's technical capabilities and its suitability for installation and operation within the utility environment. In this project, the world's first underground installation of an HTS cable using existing ductwork, a 120 meter demonstration cable circuit was designed and installed between the 24 kV bus distribution bus and a 120 kV-24 kV transformer at Detroit Edison's Frisbie substation. The system incorporated cables, accessories, a refrigeration system, and control instrumentation. Although the system was never put in operation because of problems with leaks in the cryostat, the project significantly advanced the state-of-the-art in the design and implementation of Warm Dielectric cable systems in substation applications. Lessons learned in this project are already being incorporated in several ongoing demonstration projects.

  6. The Detroit Diesel DELTA Engine for Light Trucks and SUVs - Year 2000 Update

    SciTech Connect (OSTI)

    Nabil S. Hakim; Charles E. Freese; Stanley P. Miller

    2000-06-19

    Detroit Diesel Corporation (DDC) is developing the DELTA 4.0L V6 engine, specifically for the North American light truck market. This market poses unique requirements for a diesel engine, necessitating a clean sheet engine design. DELTA was developed from a clean sheet of paper, with the first engine firing just 228 days later. The process began with a Quality Function Deployment (QFD) analysis, which prioritized the development criteria. The development process integrated a co-located, fully cross-functional team. Suppliers were fully integrated and maintained on-site representation. The first demonstration vehicle moved under its own power 12 weeks after the first engine fired. It was demonstrated to the automotive press 18 days later. DELTA has repeatedly demonstrated its ability to disprove historical North American diesel perceptions and compete directly with gasoline engines. This paper outlines the Generation 0.0 development process and briefly defines the engine. A brief indication of the Generation 0.5 development status is given.

  7. Real-time sub-<mi>>ngstrom...

    Office of Scientific and Technical Information (OSTI)

    Real-time sub-<mi>>ngstrom imaging of reversible and irreversible conformations in rhodium catalysts and graphene Kisielowski, Christian; Wang,...

  8. Mi GmbH | Open Energy Information

    Open Energy Info (EERE)

    Mi GmbH Jump to: navigation, search Name: Mi GmbH Place: Switzerland Zip: CH-6340 Sector: Solar Product: Baar-based manufacturer and distributor of fruit juices. The firm is also...

  9. miRNAs in brain development

    SciTech Connect (OSTI)

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan

    2014-02-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

  10. DOE - Office of Legacy Management -- Michigan Velsicol Chemical Corp - MI

    Office of Legacy Management (LM)

    03 Michigan Velsicol Chemical Corp - MI 03 FUSRAP Considered Sites Site: MICHIGAN [VELSICOL] CHEMICAL CORP. (MI.03 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Velsicol Chemical Corp. MI.03-1 Location: St. Louis , Michigan MI.03-2 Evaluation Year: Circa 1987 MI.03-3 Site Operations: Rare earth processing facility. MI.03-2 Site Disposition: Eliminated - No Authority - NRC survey MI.03-3 Radioactive Materials Handled: Yes Primary Radioactive

  11. DOE - Office of Legacy Management -- Star Cutter Corp - MI 15

    Office of Legacy Management (LM)

    Star Cutter Corp - MI 15 FUSRAP Considered Sites Site: STAR CUTTER CORP. (MI.15) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Farmington , Michigan MI.15-1 Evaluation Year: 1991 MI.15-2 Site Operations: Performed a one time uranium slug drilling operation test in 1956. MI.15-3 MI.15-1 Site Disposition: Eliminated - Potential for contamination considered remote based on limited scope and quantity of materials handled MI.15-2 Radioactive

  12. Hydroacoustic Evaluation of Juvenile Salmonid Passage and Distribution at Detroit Dam, 2011

    SciTech Connect (OSTI)

    Khan, Fenton; Royer, Ida M.; Johnson, Gary E.; Ham, Kenneth D.

    2012-11-15

    Pacific Northwest National Laboratory evaluated juvenile salmonid passage and distribution at Detroit Dam (DET) on the North Santiam River, Oregon for the U.S. Army Corps of Engineers (USACE) to provide data to support decisions on long-term measures to enhance downstream passage at DET and others dams in USACE’s Willamette Valley Project. This study was conducted in response to regulatory requirements necessitated by the listing of Upper Willamette River Spring Chinook salmon (Oncorhynchus tshawytscha) and Upper Willamette River steelhead (O. mykiss) as threatened under the Endangered Species Act. The goal of the study was to provide information of juvenile salmonid passage and distribution at DET from February 2011 through February 2012. The results of the hydroacoustic study provide new and, in some cases, first-ever data on passage estimates, run timing, distributions, and relationships between fish passage and environmental variables at the dam. This information will inform management decisions on the design and development of surface passage and collection devices to help restore Chinook salmon populations in the North Santiam River watershed above DET. During the entire study period, an estimated total of 182,526 smolt-size fish (±4,660 fish, 95% CI) passed through turbine penstock intakes. Run timing peaked in winter and early spring months. Passage rates were highest during late fall, winter and early spring months and low during summer. Horizontal distribution for hours when both turbine units were operated simultaneously indicated Unit 2 passed almost twice as much fish as Unit 1. Diel distribution for smolt-size fish during the study period was fairly uniform, indicating fish were passing the turbines at all times of the day. A total of 5,083 smolt-size fish (± 312 fish, 95% CI) were estimated passed via the spillway when it was open between June 23 and September 27, 2011. Daily passage was low at the spillway during the June-August period, and

  13. DOE - Office of Legacy Management -- Adrian - MI 01

    Office of Legacy Management (LM)

    Adrian - MI 01 FUSRAP Considered Sites Adrian, MI Alternate Name(s): Bridgeport Brass Co. Special Metals Extrusion Plant Bridgeport Brass Company General Motors General Motors Company, Adrian MI.01-1 Location: 1450 East Beecher Street, Adrian, Michigan MI.01-3 Historical Operations: Performed uranium extrusion research and development and metal fabrication work for the AEC using uranium, thorium, and plutonium. MI.01-2 Eligibility Determination: Eligible MI.01-1 Radiological Survey(s):

  14. Gratiot | Open Energy Information

    Open Energy Info (EERE)

    Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Detroit Edison Developer Invenergy Energy Purchaser Detroit Edison Location Breckenridge MI...

  15. DOE - Office of Legacy Management -- Oliver Corp - MI 11

    Office of Legacy Management (LM)

    Oliver Corp - MI 11 FUSRAP Considered Sites Site: OLIVER CORP. (MI.11 ) Eliminated from further consideration under FUSRAP - Referred to NRC Designated Name: Not Designated Alternate Name: Behnke Warehousing Incorporated MI.11-1 Location: 433 East Michigan Avenue , Battle Creek , Michigan MI.11-1 Evaluation Year: 1986 MI.11-4 Site Operations: Conducted production scale briquetting of green salt and magnesium blend under AEC license Nos. SNM-591, SUB-579, and C-3725. MI.11-1 MI.11-3 Site

  16. The NuMI Neutrino Beam

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; et al

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  17. MINERvA Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MINERvA Publications "Neutrino Flux Predictions for the NuMI Beam" "First evidence of coherent K+ meson production in neutrino-nucleus scattering" Phys. Rev. Lett. 117, 061802 (2016) "Measurement of K+ production in charged-current νμ interactions" Phys. Rev. D 94, 012002 (2016) "Cross sections for neutrino and antineutrino induced pion production on hydrocarbon in the few-GeV region using MINERvA" accepted for publication by PRD "Evidence for

  18. DOE - Office of Legacy Management -- Naval Ordnance Plant - MI...

    Office of Legacy Management (LM)

    Eliminated from further consideration under FUSRAP - Referred to DoD for action Designated ... MI.0-03-1 Site Disposition: Eliminated - No Authority - Referred to DoD MI.0-03-1 ...

  19. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    SciTech Connect (OSTI)

    Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  20. Characterization of Fish Passage Conditions through a Francis Turbine, Spillway, and Regulating Outlet at Detroit Dam, Oregon, Using Sensor Fish, 2009

    SciTech Connect (OSTI)

    Duncan, Joanne P.; Carlson, Thomas J.

    2011-05-06

    Fish passage conditions through two spillways, a Francis turbine, and a regulating outlet (RO) at Detroit Dam on the North Santiam River in Oregon were evaluated by Pacific Northwest National Laboratory for the U.S. Army Corps of Engineers (USACE), Portland District, using Sensor Fish devices. The objective of the study was to describe and compare passage exposure conditions, identifying potential fish injury regions within the routes. The study was performed in July, October, and December 2009 concurrent with HI-Z balloon-tag studies by Normandeau Associates, Inc. Sensor Fish data were analyzed to estimate 1) exposure conditions, particularly exposure to severe strike, collision, and shear events by passage route sub-regions; 2) differences in passage conditions between passage routes; and 3) relationships to live-fish injury and mortality data estimates. Comparison of the three passage routes evaluated at Detroit Dam indicates that the RO passage route through the 5-ft gate opening was relatively the safest route for fish passage under the operating conditions tested; turbine passage was the most deleterious. These observations were supported also by the survival and malady estimates obtained from live-fish testing. Injury rates were highest for turbine and spillway passage. However, none of the passage routes tested is safe for juvenile salmonid passage.

  1. “Nodal Gap” induced by the incommensurate diagonal spin density modulation in underdoped high- <mi>Tmi>c> superconductors

    SciTech Connect (OSTI)

    Zhou, Tao; Gao, Yi; Zhu, Jian -Xin

    2015-03-07

    Recently it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the <mi>d>-wave nodal lines (nodal gap) contrasts the common understanding of the <mi>d>-wave pairing symmetry, which challenges the present theories for the high-<mi>Tmi><mi>c>superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high-<mi>Tmi><mi>c>superconductors.

  2. Characterization of function and regulation of miR-24-1 and miR-31

    SciTech Connect (OSTI)

    Sun Fenyong; Wang Jiayi; Pan Qiuhui; Yu Yongchun; Zhang Yue; Wan Yang; Wang Ju; Li Xiaoyan; Hong An

    2009-03-13

    To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b{approx}27b{approx}24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together.

  3. Detroit Commuter Hydrogen Project

    Office of Energy Efficiency and Renewable Energy (EERE)

    2009 DOE Hydrogen Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting, May 18-22, 2009 -- Washington D.C.

  4. DOE - Office of Legacy Management -- Dow Chemical Co - Midland - MI 06

    Office of Legacy Management (LM)

    Midland - MI 06 FUSRAP Considered Sites Site: Dow Chemical Co. - Midland (MI.06 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Midland , Michigan MI.06-1 Evaluation Year: Circa 1987 MI.06-2 Site Operations: Conducted development work for production of magnesium-thorium alloys. MI.06-1 Site Disposition: Eliminated - AEC licensed site MI.06-1 MI.06-2 Radioactive Materials Handled: Yes Primary Radioactive Materials Handled:

  5. ARM - Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    govPublications Publications Journal Articles Conference Documents Program Documents & Technical Reports Publications Database Public Information Materials Image Library Videos Publication Resources Submit a Publication Publishing Procedures ARM Style Guide (PDF, 448KB) Acronyms Glossary Logos Contacts RSS for Publications Publications Investigators who use Atmospheric Radiation Measurement (ARM) Climate Research Facility data are major contributors to atmospheric research aimed toward

  6. DOE - Office of Legacy Management -- General Motors Co - Flint - MI 07

    Office of Legacy Management (LM)

    Motors Co - Flint - MI 07 FUSRAP Considered Sites Site: GENERAL MOTORS CO. (MI.07 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: A.C. Spark Plug Dort Highway Plant MI.07-1 MI.07-2 Location: Flint , Michigan MI.07-1 Evaluation Year: 1987 MI.07-3 Site Operations: Processed thorium oxide, uranium oxide, and beryllium oxide into crucibles for the Chicago Area. MI.07-3 MI.07-4 MI.07-5 Site Disposition: Eliminated - Potential for contamination

  7. Magnetocrystalline anisotropy in <mi>UMn>2<mi>Ge>2 and related Mn-based actinide ferromagnets

    SciTech Connect (OSTI)

    Parker, David S.; Ghimire, Nirmal; Singleton, John; Thompson, J. D.; Bauer, Eric D.; Baumbach, Ryan; Mandrus, David; Li, Ling; Singh, David J.

    2015-05-04

    We present magnetization isotherms in pulsed magnetic fields up to 62 Tesla, supported by first principles calculations, demonstrating a huge uniaxial magnetocrystalline anisotropy energy - approximately 20 MJ/m3 - in <mi>UMn>2<mi>Ge>2. This large anisotropy results from the extremely strong spin-orbit coupling affecting the uranium 5 f electrons, which in the calculations exhibit a substantial orbital moment exceeding 2 μB. Finally, we also find from theoretical calculations that a number of isostructural Mn-actinide compounds are expected to have similarly large anisotropy.

  8. LBNL: Architecture 2030 District Program and Small Commercial...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Silicon Valley City of San Jose - San Jose, CA - Arizona State University - Phoenix, AZ - Emerging 2030 Districts - Ann Arbor, MI; Detroit, MI; San Antonio, TX; Ithaca, ...

  9. Tax Credits, Rebates & Savings | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Detroit Public Lighting Department- Commercial and Industrial Energy Wise Program The Detroit Public Lighting Department (PLD) offers commercial and industrial customers rebates...

  10. Tax Credits, Rebates & Savings | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Detroit Public Lighting Department- Commercial and Industrial Energy Wise Program The Detroit Public Lighting Department (PLD) offers commercial and industrial customers...

  11. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect (OSTI)

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  12. miR-92a family and their target genes in tumorigenesis and metastasis

    SciTech Connect (OSTI)

    Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang

    2014-04-15

    The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.

  13. Publications | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publications The NREL Publications Database contains bibliographic information about publications developed or written by NREL staff and subcontractors. Search the database for publications from 1977 to the present on subjects related to renewable energy and energy-efficient technologies. Many publications are available electronically as Adobe Acrobat PDFs. The database includes technical reports, journal articles, conference papers, patents, presentations, books, fact sheets, and brochures.

  14. Public Meetings

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Public Meetings Individual Permit: Public Meetings Subscribe to receive notifications for semiannual Individual Permit for Storm Water public meetings. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email Public meeting notifications LANL will email a draft agenda at least one week before the meeting and will consider suggestions from the public for changes or additions to the agenda. Upcoming Meetings 2016 Meeting Archives

  15. WINDExchange: Publications

    Wind Powering America (EERE)

    Information Resources Printable Version Bookmark and Share Publications Webinars Podcasts Economic Development Studies Wind Turbine Ordinances Awards Publications This page lists all of the publications referenced on the WINDExchange initiative's website. Search the WINDExchange Database Choose a Subject Category All Agricultural Public Power Schools Small Wind Economic Development Policy Start Search Clear Search Filtered by: Publication Date State Program Area Title 10/1/2016 Public Power

  16. Related Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Skip navigation links Financial Information Financial Public Processes Asset Management Cost Verification Process Rate Cases BP-18 Rate Case Related Publications Meetings...

  17. DOE - Office of Legacy Management -- Baker-Perkins Co - MI 13

    Office of Legacy Management (LM)

    Baker-Perkins Co - MI 13 FUSRAP Considered Sites Site: Baker-Perkins Co (MI 13) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Saginaw , Michigan MI.13-1 Evaluation Year: 1991 MI.13-1 MI.13-2 Site Operations: Small scale oxide mixing demonstrations and testing in May, 1956. MI.13-2 Site Disposition: Eliminated - Potential for contamination remote based on limited scope of activities at the site MI.13-3 Radioactive Materials Handled: Yes

  18. CNEEC - Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CNEEC archival journal publications CNEEC maintains two lists of publications, one devoted to research solely supported by funding from the CNEEC EFRC and another containing publications jointly supported by the CNEEC EFRC and other sources. These lists are downloadable in both DOCX and PDF formats below. CNEEC publications solely supported by the EFRC Download Word file Download PDF file CNEEC publications supported jointly by other sources Download Word file Download PDF file Center on

  19. miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

    SciTech Connect (OSTI)

    Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao

    2014-02-07

    Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.

  20. ARM - Public Information Materials

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    govPublicationsPublic Information Materials Publications Journal Articles Conference Documents Program Documents Technical Reports Publications Database Public Information...

  1. Tax Credits, Rebates & Savings | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Detroit Green Fund Loan The Economic Development Corporation (EDC) of the City of Detroit is offering financial assistance to commercial, institutional and public buildings...

  2. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    SciTech Connect (OSTI)

    Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  3. Public Activities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    passes. Roadways that are off limits to visiting members of the public will be posted with signs, and motorists will be given site maps to guide them to the public areas....

  4. Public Activities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bird Watching Effective January 24, 2005 There are several great bird watching spots in the public areas on Fermilab's site. Driving is restricted to the roads within the public...

  5. Publication Policy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    publication policy Publication Policy Publication of work performed at JLF JLF encourages dissemination of results of experiments performed at the Facility. Vehicles for the publication may include: Journal articles Conference proceedings articles Books or book chapters Technical reports Dissertations Published patents Published abstracts Invited or contributed talks Popular articles Press reports The decision whether to publish and in what form(s) is the responsibility of the Principal

  6. UNIRIB: Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    UNIRIB Publications The University Radioactive Ion Beam (UNIRIB) consortium contributes to numerous scholarly publications and presents research at a variety of international conferences. The following links provide bibliographical information about each article UNIRIB and its staff have published in recent years. 2013 bibliography 2012 bibliography 2011 bibliography 2010 bibliography 2009 bibliography 2008 bibliography 2007 bibliography 2006 bibliography Publications

  7. DOE - Office of Legacy Management -- Mitts-Merrill Co - MI 14

    Office of Legacy Management (LM)

    Mitts-Merrill Co - MI 14 FUSRAP Considered Sites Site: MITTS and MERRILL CO. (MI.14 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Genessee Packing Co. MI.14-1 Location: Saginaw, Michigan MI.14-1 Evaluation Year: 1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces on a small test scale during the mid-1950s. MI.14-1 Site Disposition: Eliminated - Potential for contamination considered remote based on limited quantity

  8. miRNA-205 affects infiltration and metastasis of breast cancer

    SciTech Connect (OSTI)

    Wang, Zhouquan; Department of Tumor, SenGong Hospital of Shaanxi, Xian 710300 ; Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng; Ren, Hong

    2013-11-08

    Highlights: We detected expression of miR-205 in breast cancer cell lines and tissue samples. We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. We suggest the lower expression of miR-205 play a role in breast cancer onset. These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

  9. NuMI Low Energy Flux Prediction Release

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NuMI Low Energy Flux Prediction Release Neutrino Flux Predictions for the NuMI Beam hep-ex/1607.00704 Data Ancillary data files for this result are available on arXiv at http://arxiv.org/src/1607.00704/anc.< /li> Among the available data files are: pdf file describing format of all the available files root file of all the available fluxes python code to read and process MINERvA's flux predictions Text Files of the flux, uncertainties, and covariance matrix, with units of neutrinos/m^2/POT,

  10. Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1 1 1 1 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S. Liquefied Natural Gas Exports by Point of Exit Port Huron, MI LNG Exports to All Countries

  11. Ground Motion Studies at NuMI

    SciTech Connect (OSTI)

    Mayda M. Velasco; Michal Szleper

    2012-02-20

    Ground motion can cause significant deterioration in the luminosity of a linear collider. Vibration of numerous focusing magnets causes continuous misalignments, which makes the beam emittance grow. For this reason, understanding the seismic vibration of all potential LC sites is essential and related efforts in many sites are ongoing. In this document we summarize the results from the studies specific to Fermilab grounds as requested by the LC project leader at FNAL, Shekhar Mishra in FY04-FY06. The Northwestern group focused on how the ground motion effects vary with depth. Knowledge of depth dependence of the seismic activity is needed in order to decide how deep the LC tunnel should be at sites like Fermilab. The measurements were made in the NuMI tunnel, see Figure 1. We take advantage of the fact that from the beginning to the end of the tunnel there is a height difference of about 350 ft and that there are about five different types of dolomite layers. The support received allowed to pay for three months of salary of Michal Szleper. During this period he worked a 100% of his time in this project. That include one week of preparation: 2.5 months of data taking and data analysis during the full period of the project in order to guarantee that we were recording high quality data. We extended our previous work and made more systematic measurements, which included detailed studies on stability of the vibration amplitudes at different depths over long periods of time. As a consequence, a better control and more efficient averaging out of the daytime variation effects were possible, and a better study of other time dependences before the actual depth dependence was obtained. Those initial measurements were made at the surface and are summarized in Figure 2. All measurements are made with equipment that we already had (two broadband seismometers KS200 from GEOTECH and DL-24 portable data recorder). The offline data analysis took advantage of the full Fourier spectra

  12. PNNL: Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Welcome to the Pacific Northwest National Laboratory publications page. You can use this page to find citations to materials published since 1998 by PNNL staff or by external researchers using PNNL facilities. The latter are denoted by a logo preceding the citation. Full text copies of many PNNL formal reports are available from this page either as PDF or HTML files. Search Tips Help Select Search Criteria Publication Types All Publications Journal Article Formal Report Conference Paper

  13. Publications - JCAP

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    056.JPG Publications Research Why Solar Fuels Goals & Objectives Thrust 1 Thrust 2 Thrust 3 Thrust 4 Publications Research Highlights Videos Innovations User Facilities Expert Team Benchmarking Database Device Simulation Tool XPS Spectral Database Research Introduction Why Solar Fuels? Goals & Objectives Thrusts Thrust 1 Thrust 2 Thrust 3 Thrust 4 Library Publications Research Highlights Videos Resources User Facilities Expert Team Benchmarking Database Device Simulation Tool XPS

  14. ARM - Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HomeroomPublications Outreach Home Room News Publications Traditional Knowledge Kiosks Barrow, Alaska Tropical Western Pacific Site Tours Contacts Students Study Hall About ARM Global Warming FAQ Just for Fun Meet our Friends Cool Sites Teachers Teachers' Toolbox Lesson Plans Publications Climate Education Update Newsletter Would you like to receive our bi-annual newsletter directly to your inbox? Send your contact information to pubs@arm.gov to be added to our distribution. January 2013 An

  15. Publications | NISAC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Technical Assistance » Combined Heat & Power Deployment » Publications Publications Thumbnail image of the cover for the Combined Heat and Power (CHP): A Decade of Progress, A Vision for the Future, October 2009 Numerous publications are available to help educate end users, product developers, project managers, and policymakers on the many potential benefits of distributed generation and combined heat and power (CHP) and the barriers to widespread deployment of these technologies. Among

  16. DOE - Office of Legacy Management -- Mitts-Merrel Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  17. Geothermal Publications

    Broader source: Energy.gov [DOE]

    Here you'll find the Department of Energy's most recent publications about enhanced geothermal systems (EGS) technologies and research and development activities.

  18. Public Participation

    Broader source: Energy.gov [DOE]

    Maintaining an open dialog with the public is central to the mission of the Environmental Management Los Alamos Field Office (EM-LA).

  19. EC Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ElectricalSimulationsofSeriesandParallelPVArc-Faults(Presentation)admin2016-04-14T2... All Publications Placeholder Download Filename 39thPVSCElectricalSimulationsofSeriesa...

  20. ARM Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fri, 02 Sep 2016 18:59:06 +0000 http://www.arm.gov en Publication Notice: New Technical Report Available Fri, 02 Sep 2016 18:59:06 +0000 Publications http://www.arm.gov/publications?date=20160902#20160902 Dubey M, A Aiken, LK Berg, A Freedman, and K Gorkowski. 2016. &#60;a href=&#34;https://www.arm.gov/publications/programdocs/doe-sc-arm-16-047.pdf&#34; class=&#34;external&#34;&#62;Two-Column Aerosol Project: Aerosol Light Extinction Measurements Field Campaign

  1. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

    SciTech Connect (OSTI)

    Guo, Li-Juan; Liao, Lan; Yang, Li; Li, Yu; Jiang, Tie-Jian

    2014-02-15

    MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.

  2. DOE - Office of Legacy Management -- Amex Specialty Metal Corp - MI 0-01

    Office of Legacy Management (LM)

    Amex Specialty Metal Corp - MI 0-01 FUSRAP Considered Sites Site: Amex Specialty Metal Corp (MI.0-01 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Coldwater , Michigan MI.0-01-1 Evaluation Year: 1987 MI.0-01-1 Site Operations: No indication that AMEX performed work for MED or AEC activities. Originally included on FUSRAP list due to fact that AMEX purchased milling equipment from a company that had done uranium milling.

  3. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma

    SciTech Connect (OSTI)

    Xiong, Xinkui; Sun, Daoyi; Chai, Hao; Shan, Wengang; Yu, Yue; Pu, Liyong; Cheng, Feng

    2015-09-18

    The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression of miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.

  4. Neutron scattering study of spin ordering and stripe pinning in superconducting <mi>La>1.93<mi>Sr>0.07<mi>CuO>4

    SciTech Connect (OSTI)

    Jacobsen, H.; Zaliznyak, I. A.; Savici, A. T.; Winn, B. L.; Chang, S.; Hücker, M.; Gu, G. D.; Tranquada, J. M.

    2015-11-20

    The relationships among charge order, spin fluctuations, and superconductivity in underdoped cuprates remain controversial. We use neutron scattering techniques to study these phenomena in <mi>La>1.93<mi>Sr>0.07<mi>CuO>4 a superconductor with a transition temperature of Tc = 20 K. At T<< Tc, we find incommensurate spin fluctuations with a quasielastic energy spectrum and no sign of a gap within the energy range from 0.2 to 15 meV. A weak elastic magnetic component grows below ~ 10 K, consistent with results from local probes. Regarding the atomic lattice, we have discovered unexpectedly strong fluctuations of the CuO6 octahedra about Cu-O bonds, which are associated with inequivalent O sites within the CuO2 planes. Moreover, we observed a weak elastic (3 30) superlattice peak that implies a reduced lattice symmetry. The presence of inequivalent O sites rationalizes various pieces of evidence for charge stripe order in underdoped La2-xSrxCuO4. The coexistence of superconductivity with quasi-static spin-stripe order suggests the presence of intertwined orders; however, the rotation of the stripe orientation away from the Cu-O bonds might be connected with evidence for a finite gap at the nodal points of the superconducting gap function.

  5. Radiosensitizing Effects of Ectopic miR-101 on Non-Small-Cell Lung Cancer Cells Depend on the Endogenous miR-101 Level

    SciTech Connect (OSTI)

    Chen, Susie; Wang Hongyan; Ng, Wooi Loon; Curran, Walter J.; Wang Ya

    2011-12-01

    Purpose: Previously, we showed that ectopic miR-101 could sensitize human tumor cells to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA repair, as the endogenous miR-101 levels are low in tumors in general. However, the heterogeneity of human cancers may result in an exception. The purpose of this study was to test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101 would prove less response to ectopic miR-101. Methods and Materials: Fourteeen non-small-cell lung cancer (NSCLC) cell lines and one immortalized non-malignant lung epithelial cell line (NL20) were used for comparing endogenous miR-101 levels by real-time reverse transcription-polymerase chain reaction. Based on the different miR-101 levels, four cell lines with different miR-101 levels were chosen for transfection with a green fluorescent protein-lentiviral plasmid encoding miR-101. The target protein levels were measured by using Western blotting. The radiosensitizing effects of ectopic miR-101 on these NSCLC cell lines were determined by a clonogenic assay and xenograft mouse model. Results: The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. Similar results were observed in xenograft mice. Conclusions: A small number of NSCLC cell lines could have a high level of endogenous miR-101. The ectopic miR-101 was able to radiosensitize most NSCLC cells, except for the NSCLC cell lines that had a much higher endogenous miR-101 level. These results suggest that when we choose one miRNA as a therapeutic tool, the endogenous level of the miRNA in each tumor should be considered.

  6. Public Library.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    d 1 Greet the metal turtles at the Mesa Public Library. 2 Take a tour of public art. 3 Start from Ashley Pond and find the smart house. 4 Test your electric personality at the Bradbury Science Museum. 5 Sit a spell in the Romero Cabin. 6 Walk the Rim Trail. 7 Dress up the Oppie and Groves statues. 8 Attend a Gordon's concert. 9 Put together a team for the mud volleyball tournament. 10 Hear authors speak or attend a gallery opening at Mesa Public Library. 11 Hike to the Cave Of The Winds. 12 Join

  7. ARM Publications Database

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    govPublicationsPublications Database Publications Database Submit a Publication Would your publication make a good research highlight? Submit one now. Comments? Need a change to an...

  8. EC Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Wolf-bioadmin2016-04-18T20:58:24+00:00 Popular Downloads Solar Energy Grid Integration ... All Publications Placeholder Download Filename Wolf-bio.pdf filesize 36.22 kB Version 1 ...

  9. EC Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    All Publications Go Back Order by: Title Date added Download count A Conceptual Model ... Hyperspectral Imaging (604) HyRAM 1.0.1 (421) Isotropically etched radial micropore for ...

  10. EC Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    All Publications Go Back Order by: Title Date added Download count A toolkit for ... and Fuel Cells Program (1273) HyRAM 1.0.1 (421) HyRAM: A methodology and toolkit for ...

  11. Public Activities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Art Gallery The Art Gallery in Wilson Hall is only open to the public before and after Arts, Lectures and Film Series events. The Gallery is closed to unescorted visitors at all...

  12. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Phase diagram of Josephson junction between<mi>s>and<mi>s>superconductors in the dirty...

  13. General Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    General Publications General Publications Print ALS Strategic Plan 2015-19 cover image An updated version of the ALS Strategic Plan, covering the five-year period from 2015 to 2019. As in the 2014-18 version, Section I gives a brief synopsis on beamline and endstation projects. The science drivers behind these projects are explained in greater detail in Section II, and a very brief description of emerging plans for a ALS-U are in Section III. Soft X-ray Science Opportunities Using

  14. Thermoelectric Conversion of Wate Heat to Electricity in an IC Engine Powered Vehicle

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  15. Advantages of Oxygenates Fuels over Gasoline in Direct Injection Spark Ignition Engines

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  16. Development of Optimal Catalyst Designs and Operating Strategies for Lean NOx Reduction in Coupled LNT-SCR Systems

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  17. Development of an SI DI Ethanol Optimized Flex Fuel Engine Using Advanced Valvetrain

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  18. Magnesium Replacement of Aluminum Cast Components in a Production V6 Engine to Effect Cost-Effective Mass Reduction

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  19. Diesel Particulate Oxidation Model: Combined Effects of Fixed & Volatile Carbon

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  20. Mr. Shaun Maloney :

    Office of Legacy Management (LM)

    ... Detroit, MI 48232 Chambersburg Engineering Co. Chambersburg, PA Ithaca Gun Co. Ithaca, NY New England Materials Lab., Inc. Teledyne Materials' . Medford, MA NRC Equipment Co. . -. ...

  1. Development of HC-SCR System Using Diesel Fuel as a Reductant

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  2. Advanced Diesel Combustion with Low Hydrocarbon and Carbon Monoxide Emissions

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  3. New Developments in Titania-Based Catalysts for Selective Catalytic Reduction of NOx

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  4. Slide 1

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  5. An Analytical Approach for Tail-Pipe Emissions Estimation with...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    with Coupled Engine and Aftertreatment System Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September ...

  6. Validation of a Small Engine Based Procedure for Studying Performance...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for Engine Friction Reduction and Durable Design Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September ...

  7. Heritage Garden | Open Energy Information

    Open Energy Info (EERE)

    Energy Developer Heritage Sustainable Energy Energy Purchaser Consumers Energy Detroit Edison Location Garden MI Coordinates 45.776334, -86.5527241 Show Map Loading...

  8. AVL Powertrain Engineering | Open Energy Information

    Open Energy Info (EERE)

    successadvisor.html AVL Powertrain Engineering is a company located in Detroit, MI. References "AVL" Retrieved from "http:en.openei.orgw...

  9. General Motors | Open Energy Information

    Open Energy Info (EERE)

    Motors Jump to: navigation, search Name: General Motors Place: Detroit, MI Website: www.generalmotors.com References: General Motors1 Information About Partnership with NREL...

  10. Slide Title

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  11. Detection of Ammonia Slip Using NOx Sensor Signal Processing

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  12. Development of a Thermal Enhancer ’ for Combined Partial Range Burning and Hydrocarbon Dosing

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  13. Development of Urea Dosing System for 10 Liter Heavy Duty Diesel Engine Powered Vehicle

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  14. Engine Waste Heat Recovery Concept Demonstration

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  15. A Thermoelectric Generator with an Intermediate Heat Exchanger for Automotive Waste Heat Recovery System

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  16. Evaluation of Variable Compression Ratio on Energy Efficiency

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  17. Efficient Thermally Variable Cooling System

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  18. Improving the NOx-CO2 Trade-Off of an HCCI Engine using a Multi...

    Office of Scientific and Technical Information (OSTI)

    16-19, 2007 in Detroit, MI. Research Org: Sandia National Laboratories (SNL-CA), Livermore, CA (United States) Sponsoring Org: USDOE National Nuclear Security Administration ...

  19. The Impact of Using Derived Fuel Consumption Maps to Predict Fuel Consumption

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  20. Thermal Energy Storage Technology for Transportation and Other Applications D. Bank, M. Maurer, J. Penkala, K. Sehanobish, A. Soukhojak

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  1. Factors Impacting EGR Cooler Fouling- Main Effects and Interactions

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  2. DTE | Open Energy Information

    Open Energy Info (EERE)

    Link to project description http:www.intelligentutility.comarticle1101energy-storage-nrel DTE is a company located in Detroit, MI. References "DTE Energy"...

  3. A Simple Approach of Tuning Catalytic Activity of MFI-Zeolites for Low-Temperature SCR of NOx

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  4. Improving Diesel Engine Sweet-spot Efficiency and Adapting it to Improve Duty-cycle MPG- plus Increasing Propulsion and Reducing Cost

    Office of Energy Efficiency and Renewable Energy (EERE)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  5. Thermoelectric Generator Development for Automotive Waste Heat Recovery

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  6. Modular Low Cost High Energy Exhaust Heat Thermoelectric Generator with Closed-Loop Exhaust By-Pass System

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  7. A University Consortium on High Pressure, Lean Combustion for Efficient and Clean IC Engines (UM- lead, MIT, UCB)

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  8. Load Expansion of Stoichiometric HCCI Using Spark Assist and Hydraulic Valve Actuation

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  9. Sources of UHC and CO in Low Temperature Automotive Diesel Combustion Systems

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  10. Two in One: SCR on Filter

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  11. Functionality of Commercial NOx Storage-Reduction Catalysts and the Development of a Representative Model

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  12. Function Specific Analysis of the Thermal Durability of Cu-Zeolite SCR Catalyst

    Broader source: Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  13. Workbook Contents

    U.S. Energy Information Administration (EIA) Indexed Site

    ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Exports to Canada (MMcf)",1,"Annual",2014 ,"Release...

  14. Performance of a High Speed Indirect Injection Diesel Engine with Poultry Fat Bio-Diesel

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  15. Impact of Biodiesel Metals on the Performance and Durability of DOC and DPF Technologies

    Broader source: Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  16. Hydrogen Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publications - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear Energy

  17. Public Lecture

    ScienceCinema (OSTI)

    None

    2011-10-06

    An outreach activity is being organized by the Turkish community at CERN, on 5 June 2010 at CERN Main Auditorium. The activity consists of several talks that will take 1.5h in total. The main goal of the activity will be describing the CERN based activities and experiments as well as stimulating the public's attention to the science related topics. We believe the wide communication of the event has certain advantages especially for the proceeding membership process of Turkey.

  18. Publications - SRSCRO

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    header-nuclear Publications NWI Regional Programs 2-PAGE Overview (Revised 6_2015) Regional Nuclear Workforce Development in the Central Savannah River Area (June 2010) Nuclear Workforce Initiative®: Filling a Critical Career Need (November 2009) Nuclear Workforce Summit - Summary Report (June 2009) Booz Allen Hamilton Nuclear Workforce Survey Report (June 2009) Ensuring a Skilled Workforce for the Nuclear Renaissance (Nov 2008) Types of Nuclear Jobs Nuclear Industry Job Descriptions imag

  19. PV Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publications - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear Energy

  20. Catalyst by Design - Theoretical, Nanostructural, and Experimental Studies

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Emission Treatment Catalyst | Department of Energy Emission Treatment Catalyst Catalyst by Design - Theoretical, Nanostructural, and Experimental Studies of Emission Treatment Catalyst Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-08_narula.pdf (495.8 KB) More Documents & Publications Catalyst by Design - Theoretical, Nanostructural, and Experimental Studies of Oxidation Catalyst for

  1. Efficiency Considerations of Diesel Premixed Charge Compression Ignition

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Combustion | Department of Energy Considerations of Diesel Premixed Charge Compression Ignition Combustion Efficiency Considerations of Diesel Premixed Charge Compression Ignition Combustion Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-06_jacobs.pdf (226.27 KB) More Documents & Publications Biodiesel's Enabling Characteristics in Attaining Low Temperature Diesel Combustion System-Response

  2. Heavy-Duty Vehicle Field Evaluations | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Department of Energy Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_aneja.pdf (1.22 MB) More Documents & Publications BLUETEC - Heading for 50 State Diesel Vehicle Technologies Office Merit Review 2015: SuperTruck Program: Engine Project Review Vehicle Technologies Office Merit Review 2015: Class 8 Truck Freight Efficiency Improvement Project Department of Energy

    Globalization in

  3. Reductant Chemistry during LNT Regeneration for a Lean Gasoline Engine |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Chemistry during LNT Regeneration for a Lean Gasoline Engine Reductant Chemistry during LNT Regeneration for a Lean Gasoline Engine Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-09_parks.pdf (507.29 KB) More Documents & Publications Development of Optimal Catalyst Designs and Operating Strategies for Lean NOx Reduction in Coupled LNT-SCR Systems Emissions Control for Lean

  4. Development of Artificial Ash Accelerated Accumulation Test | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Artificial Ash Accelerated Accumulation Test Development of Artificial Ash Accelerated Accumulation Test Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-04_fujii.pdf (138.91 KB) More Documents & Publications Impact of Honeycomb Ceramics Geometrical Cell Design on Urea SCR System Controlled Experiments on the Effects of Lubricant/Additive (Low-Ash, Ashless) Characteristics on DPF

  5. A High Temperature Direct Vehicle Exhaust Flowmeter for Heavy Duty Diesel

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Emission Measurements. | Department of Energy A High Temperature Direct Vehicle Exhaust Flowmeter for Heavy Duty Diesel Emission Measurements. A High Temperature Direct Vehicle Exhaust Flowmeter for Heavy Duty Diesel Emission Measurements. Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-08_nevius.pdf (63.6 KB) More Documents & Publications Complex System Method to Assess Commercial Vehicle Fuel

  6. Advanced Radio Frequency-Based Sensors for Monitoring Diesel Particulate

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Filter Loading and Regeneration | Department of Energy Radio Frequency-Based Sensors for Monitoring Diesel Particulate Filter Loading and Regeneration Advanced Radio Frequency-Based Sensors for Monitoring Diesel Particulate Filter Loading and Regeneration Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_sappok.pdf (1.83 MB) More Documents & Publications Vehicle Technologies Office Merit

  7. Modeling Combustion Control for High Power Diesel Mode Switching |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Combustion Control for High Power Diesel Mode Switching Modeling Combustion Control for High Power Diesel Mode Switching Poster presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-20_banerjee.pdf (160.26 KB) More Documents & Publications Diesel Injection Shear-Stress Advanced Nozzle (DISSAN) In-Cylinder Mechanisms of PCI Heat-Release Rate Control by Fuel Reactivity

  8. An Accelerated Aging Method for Diesel Exhaust Aftertreatment Systems |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy An Accelerated Aging Method for Diesel Exhaust Aftertreatment Systems An Accelerated Aging Method for Diesel Exhaust Aftertreatment Systems Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-01_bartley.pdf (272.2 KB) More Documents & Publications Vehicle Technologies Office: 2008-2009 Fuels Technologies R&D Progress Report The Development of Rapid Aging and Poisoning

  9. An Analytical Approach for Tail-Pipe Emissions Estimation with Coupled

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Engine and Aftertreatment System | Department of Energy An Analytical Approach for Tail-Pipe Emissions Estimation with Coupled Engine and Aftertreatment System An Analytical Approach for Tail-Pipe Emissions Estimation with Coupled Engine and Aftertreatment System Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-06_miao.pdf (500.14 KB) More Documents & Publications Advanced Diesel Engine and

  10. Analyses Guided Optimization of Wide Range and High Efficiency Turbocharger

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Compressor | Department of Energy Analyses Guided Optimization of Wide Range and High Efficiency Turbocharger Compressor Analyses Guided Optimization of Wide Range and High Efficiency Turbocharger Compressor Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_sun.pdf (999.91 KB) More Documents & Publications Advanced boost system development for diesel HCCI/LTC applications Optimization of a

  11. Analysis of Piston Heat Flux for Highly Complex Piston Shapes | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Piston Heat Flux for Highly Complex Piston Shapes Analysis of Piston Heat Flux for Highly Complex Piston Shapes Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-10_lee.pdf (301.36 KB) More Documents & Publications Optical Measurement Methods used in Calibration and Validation of Modeled Injection Spray Characteristics The Opposed-Piston Two-Stroke Engine Alternative: Performance and

  12. Heavy-Duty Powertrain DevelopmentCurrent Status and Future Opportunities |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy DevelopmentCurrent Status and Future Opportunities Heavy-Duty Powertrain DevelopmentCurrent Status and Future Opportunities Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_aneja.pdf (1.22 MB) More Documents & Publications BLUETEC - Heading for 50 State Diesel Vehicle Technologies Office Merit Review 2015: SuperTruck Program: Engine Project Review Vehicle Technologies

  13. High Efficient Clean Combustion for SuperTruck | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Efficient Clean Combustion for SuperTruck High Efficient Clean Combustion for SuperTruck Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_stanton.pdf (1.76 MB) More Documents & Publications Supertruck technologies for 55% thermal efficiency and 68% freight efficiency Cummins SuperTruck Program - Technology Demonstration of Highly Efficient Clean, Diesel Powered Class 8 Trucks Technology

  14. High-Efficiency Engine Technologies Session Introduction | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy High-Efficiency Engine Technologies Session Introduction High-Efficiency Engine Technologies Session Introduction Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_rotz.pdf (2.26 MB) More Documents & Publications Increased Engine Efficiency via Advancements in Engine Combustion Systems Super Truck -- 50% Improvement In Class 8 Freight Efficiency Vehicle Technologies Office Merit

  15. Increased Engine Efficiency via Advancements in Engine Combustion Systems |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Engine Efficiency via Advancements in Engine Combustion Systems Increased Engine Efficiency via Advancements in Engine Combustion Systems Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_sisken.pdf (978.17 KB) More Documents & Publications High-Efficiency Engine Technologies Session Introduction Demonstrating and Validating a Next Generation Model-Based Controller for

  16. Cylinder Head Gasket with Integrated Combustion Pressure Sensors |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Cylinder Head Gasket with Integrated Combustion Pressure Sensors Cylinder Head Gasket with Integrated Combustion Pressure Sensors Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-17_wlodarczyk.pdf (668.6 KB) More Documents & Publications Glow Plug Integrated Piezo-Ceramic Combustion Sensor for Diesel Engines Flex Fuel Optimized SI and HCCI Engine Heavy-Duty HCCI Development

  17. SwRI's HEDGE Technology for High Efficiency, Low Emissions Gasoline Engines

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy SwRI's HEDGE Technology for High Efficiency, Low Emissions Gasoline Engines SwRI's HEDGE Technology for High Efficiency, Low Emissions Gasoline Engines Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_alger.pdf (1.16 MB) More Documents & Publications Developments in High Efficiency Engine Technologies and an Introduction to SwRI's Dedicated EGR Concept Development

  18. Thermoelectric Couple Demonstration of (In, Ce)-based Skutterudite

    Broader source: Energy.gov (indexed) [DOE]

    Powered Vehicle | Department of Energy Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_schock.pdf (2.44 MB) More Documents & Publications Thermoelectric Conversion of Waste Materials for Automotive Energy Recovery | Department of Energy

    Presents recent accomplishments and couple test results with these (In, Ce)-based skutterudite TE materials and potential impacts TE power system

  19. Thermoelectric Generator Performance for Passenger Vehicles | Department of

    Broader source: Energy.gov (indexed) [DOE]

    Department of Energy Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_meisner.pdf (2.38 MB) More Documents & Publications Develop Thermoelectric Technology for Automotive Waste Heat Recovery Advanced Thermoelectric Materials and Generator Technology for Automotive Waste Heat at GM Advanced Thermoelectric Materials and Generator Technology for Automotive Waste Heat at GM Energy

  20. To: President George W. Bush United States of America To: President V.V. Putin

    Broader source: Energy.gov (indexed) [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-04_gaines.pdf (185.08 KB) More Documents & Publications A High Temperature Direct Vehicle Exhaust Flowmeter for Heavy Duty Diesel Emission Measurements. Development of Artificial Ash Accelerated Accumulation Test An Analytical Approach for Tail-Pipe Emissions Estimation with Coupled Engine and Aftertreatment System

    September 19, 2014 To Whom It May

  1. Vertically Integrated Mass Production of Automotive Class Lithium Ion

    Broader source: Energy.gov (indexed) [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_fairbanks.pdf (3.36 MB) More Documents & Publications Thermoelectrics: The New Green Automotive Technology Vehicular Thermoelectrics: A New Green Technology Vehicular Thermoelectrics: A Fleets | Department of Energy

    With their presence in almost every neighborhood and community, refuse trucks, like the one shown above, can benefit from

  2. Leading Edge Technology in Diesel Emissions Control | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Leading Edge Technology in Diesel Emissions Control Leading Edge Technology in Diesel Emissions Control Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-02_roberts.pdf (193.56 KB) More Documents & Publications NO2 Management in Diesel Exhaust System Experimental Evaluation of DOC Performance Using Secondary Fuel Injection Low Temperature Catalyst for Fuel Injection System

  3. Optical Measurement Methods used in Calibration and Validation of Modeled

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Injection Spray Characteristics | Department of Energy Optical Measurement Methods used in Calibration and Validation of Modeled Injection Spray Characteristics Optical Measurement Methods used in Calibration and Validation of Modeled Injection Spray Characteristics Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-07_klyza.pdf (363.89 KB) More Documents & Publications Effect of Ambient Pressure

  4. Organic Rankine Cycle Turbine for Exhaust Energy Recovery in a Heavy Truck

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Engine | Department of Energy Turbine for Exhaust Energy Recovery in a Heavy Truck Engine Organic Rankine Cycle Turbine for Exhaust Energy Recovery in a Heavy Truck Engine Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_baines.pdf (807.9 KB) More Documents & Publications Two-Stage Variable Compression Ratio (VCR) System to Increase Efficiency in Gasoline Powertrains Environmental Effects

  5. Oxidation State Optimization for Maximum Efficiency of NOx Adsorber

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Catalysts | Department of Energy State Optimization for Maximum Efficiency of NOx Adsorber Catalysts Oxidation State Optimization for Maximum Efficiency of NOx Adsorber Catalysts Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_li.pdf (1.68 MB) More Documents & Publications Lean NOx Trap Regeneration Selectivity Towards N2O -- Similarities and Differences Between H2, CO and C3H6

  6. Partial-Flow Diesel Particulate Filter of Sintered Metal Fiber Fleece |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Partial-Flow Diesel Particulate Filter of Sintered Metal Fiber Fleece Partial-Flow Diesel Particulate Filter of Sintered Metal Fiber Fleece Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-05_lu.pdf (452.18 KB) More Documents & Publications Advanced Metal Fiber Wall-Flow DPF For Diesel Emission Control Requirements from Particulate Filter Technology for Commercial Vehicles:

  7. Power Generating Stationary Engines Nox Control: A Closed Loop Control

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Technology | Department of Energy Power Generating Stationary Engines Nox Control: A Closed Loop Control Technology Power Generating Stationary Engines Nox Control: A Closed Loop Control Technology Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-11_servati.pdf (355.97 KB) More Documents & Publications A Low-Cost Continuous Emissions Monitoring System for Mobile and Stationary Engine SCR/DPF

  8. Progress toward Development of a High-Efficiency Zonal Thermoelectric HVAC

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    System for Automotive Applications | Department of Energy toward Development of a High-Efficiency Zonal Thermoelectric HVAC System for Automotive Applications Progress toward Development of a High-Efficiency Zonal Thermoelectric HVAC System for Automotive Applications Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10_maranville.pdf (598.71 KB) More Documents & Publications Thermoelectric

  9. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

    SciTech Connect (OSTI)

    Lerner, Mikael; Harada, Masako; Loven, Jakob; Castro, Juan; Davis, Zadie; Oscier, David; Henriksson, Marie; Sangfelt, Olle; Grander, Dan; Corcoran, Martin M.

    2009-10-15

    The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of the microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.

  10. Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops

    SciTech Connect (OSTI)

    Green, Pamela J.

    2015-08-11

    MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.

  11. Publications | Photosynthetic Antenna Research Center

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publications Publications View: Publications by First Author Publications by Year Also see: Conference Abstracts Other Publications Facilities Publications Publications by First...

  12. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A

    SciTech Connect (OSTI)

    Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang

    2015-09-04

    MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.

  13. Microfluidic Molecular Assay Platform for the Detection of miRNAs...

    Office of Scientific and Technical Information (OSTI)

    Article: Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Post-translational Modifications at Single-cell Resolution. Citation Details...

  14. Groundwater protection for the NuMI project

    SciTech Connect (OSTI)

    Wehmann, A.; Smart, W.; Menary, S.; Hylen, J.; Childress, S.

    1997-10-01

    The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.

  15. PUBLIC SUBMISSION

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ANDREW%20J.%20FERLIC_cover_DRAFT-0002.html[2/3/2012 12:37:00 PM] PUBLIC SUBMISSION As of: February 03, 2012 Received: December 29, 2011 Status: Pending_Post Tracking No. 80f8ad44 Comments Due: January 20, 2012 Submission Type: Web Docket: DOE-HQ-2012-0004 U.S. Department of Energy Audit Guidance: For-Profit Recipients Comment On: DOE-HQ-2012-0004-0001 Audit Guidance: For-Profit Recipients Document: DOE-HQ-2012-0004-DRAFT-0002 Comment on FR Doc # 2011-32622 Submitter Information Name: ANDREW J.

  16. PUBLIC SUBMISSION

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    6.html[2/3/2012 12:44:00 PM] PUBLIC SUBMISSION As of: February 03, 2012 Received: January 19, 2012 Status: Pending_Post Tracking No. 80f9b24f Comments Due: January 20, 2012 Submission Type: Web Docket: DOE-HQ-2012-0004 U.S. Department of Energy Audit Guidance: For-Profit Recipients Comment On: DOE-HQ-2012-0004-0001 Audit Guidance: For-Profit Recipients Document: DOE-HQ-2012-0004-DRAFT-0006 Comment on FR Doc # 2011-32622 Submitter Information Name: Eric Russell Address: 836 Thurber Drive West Apt

  17. PUBLIC SUBMISSION

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2-2012%2010-10-11-600/Document%20List%2003-02-2012%2010-10-11-600_docs/Martin%20WeblerCover_DRAFT-0004.html[2/3/2012 12:40:30 PM] PUBLIC SUBMISSION As of: February 03, 2012 Received: January 05, 2012 Status: Pending_Post Tracking No. 80f8e384 Comments Due: January 20, 2012 Submission Type: Web Docket: DOE-HQ-2012-0004 U.S. Department of Energy Audit Guidance: For-Profit Recipients Comment On: DOE-HQ-2012-0004-0001 Audit Guidance: For-Profit Recipients Document: DOE-HQ-2012-0004-DRAFT-0004

  18. Public Affairs Organization Chart

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Public Affairs Organization Chart Public Affairs Communications Community Public Affairs Org Chart Education Creative Services ⇒ Navigate Section Public Affairs Communications Community Public Affairs Org Chart Education Creative Services

  19. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

    SciTech Connect (OSTI)

    Zhai, Jian; Qu, Shuping; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong

    2015-08-14

    Emerging evidence suggests that microRNAs (miRNAs) play important roles in regulating HCC development and progression; however, the mechanisms by which their specific functions and mechanisms remained to be further explored. miR-129 has been reported in gastric cancers, lung cancer and colon cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in HCC. We also found the downregulation of miR-129 occurred in nearly 3/4 of the tumors examined (56/76) compared with adjacent nontumorous tissues, which was more importantly, correlated to the advanced stage and vascular invasion. We then demonstrated that miR-129 overexpression attenuated HCC cells proliferation and invasion, inducing apoptosis in vitro. Moreover, we used miR-129 antagonist and found that anti-miR-129 promoted HCC cells malignant phenotypes. Mechanistically, our further investigations revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3’-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression. Moreover, miR-129 expression was inversely correlated with PAK5 expression in 76 cases of HCC samples. RNA interference of PAK5 attenuated anti-miR-129 mediated cell proliferation and invasion in HCC cells. Taken together, these results demonstrated that miR-129 suppressed tumorigenesis and progression by directly targeting PAK5, defining miR-129 as a potential treatment target for HCC. - Highlights: • Decreased of miR-129 is found in HCC and associated with advanced stage and metastasis. • miR-129 suppresses proliferation and invasion of HCC cells. • miR-129 directly targets the 3′ UTR of PAK5 and diminishes PAK5 expression. • PAK5 is involved in miR-129 mediated suppression functions.

  20. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19

    SciTech Connect (OSTI)

    Shan, Nianxi; Shen, Liangfang; Wang, Jun; He, Dan; Duan, Chaojun

    2015-01-02

    Highlights: • Decreased miR-153 and up-regulated ADAM19 are correlated with NSCLC pathology. • MiR-153 inhibits the proliferation and migration and invasion of NSCLC cells in vitro. • ADAM19 is a direct target of miR-153. • ADAM19 is involved in miR-153-suppressed migration and invasion of NSCLC cells. - Abstract: MiR-153 was reported to be dysregulated in some human cancers. However, the function and mechanism of miR-153 in lung cancer cells remains unknown. In this study, we investigated the role of miR-153 in human non-small-cell lung cancer (NSCLC). Using qRT-PCR, we demonstrated that miR-153 was significantly decreased in clinical NSCLC tissues and cell lines, and downregulation of miR-153 was significantly correlated with lymph node status. We further found that ectopic expression of miR-153 significantly inhibited the proliferation and migration and invasion of NSCLC cells in vitro, suggesting that miR-153 may be a novel tumor suppressor in NSCLC. Further integrated analysis revealed that ADAM19 is as a direct and functional target of miR-153. Luciferase reporter assay demonstrated that miR-153 directly targeted 3′UTR of ADAM19, and correlation analysis revealed an inverse correlation between miR-153 and ADAM19 mRNA levels in clinical NSCLC tissues. Knockdown of ADAM19 inhibited migration and invasion of NSCLC cells which was similar with effects of overexpression of miR-153, while overexpression of ADAM19 attenuated the function of miR-153 in NSCLC cells. Taken together, our results highlight the significance of miR-153 and ADAM19 in the development and progression of NSCLC.

  1. Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

    SciTech Connect (OSTI)

    Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen-Lin; Xu, Xueqing; Bai, Yun

    2014-03-28

    Highlights: • MiR-146b promotes esophageal cancer cell proliferation. • MiR-146b inhibits esophageal cancer cell apoptosis. • C/EBPβ directly binds to miR-146b promoter conserved region. • MiR-146b is up-regulated by C/EBPβ LAP2 transcriptional activation. - Abstract: Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

  2. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2

    SciTech Connect (OSTI)

    Fu, Jing; Xu, Xiaojie; Kang, Lei; Zhou, Liying; Wang, Shibin; Lu, Juming; Cheng, Long; Fan, Zhongyi; Yuan, Bin; Tian, Peirong; Zheng, Xiaofei; Yu, Chengze; Ye, Qinong; Lv, Zhaohui

    2014-03-07

    Highlights: • miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. • The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration. • The miR-30a/EYA2 axis modulates G1/S cell cycle progression. • The miR-30a/EYA2 axis is dysregulated in breast cancer patients. - Abstract: Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment.

  3. ARM - Publications: Science Team Meeting Documents: Publication...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publication Trends of ARM Research Troyan, David Brookhaven National Laboratory This study summarizes the publication record of ARM research. Items of all types listed in the ARM ...

  4. miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7

    SciTech Connect (OSTI)

    Zhou, Chuanyi; Shen, Liangfang; Mao, Lei; Wang, Bing; Li, Yang; Yu, Huizhi

    2015-02-27

    MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3′-untranslated region (3′UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. - Highlights: • miR-92a is elevated in cervical cancer tissues and cell lines. • miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion. • FBXW7 is a direct target of miR-92a. • FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells.

  5. ARM Publications Database

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DatabaseSearch Publications Database Search Submit a Publication Would your publication make a good research highlight? Submit one now. Comments? Need a change to an existing...

  6. ARM Publications Database

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DatabaseSearchTips Publications Database Search Submit a Publication Would your publication make a good research highlight? Submit one now. Comments? Need a change to an existing...

  7. miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

    SciTech Connect (OSTI)

    Zhu, Hongling; Fang, Jin; Zhang, Jichen; Zhao, Zefei; Liu, Lianyong; Wang, Jingnan; Xi, Qian; Gu, Mingjun

    2014-07-18

    Highlights: miR-182 and CHL1 expression patterns are negatively correlated. CHL1 is a direct target of miR-182 in PTC cells. miR-182 suppression inhibits PTC cell growth and invasion. CHL1 is involved in miR-182-mediated cell behavior. - Abstract: In this study, we investigated the role and underlying mechanism of action of miR-182 in papillary thyroid carcinoma (PTC). Bioinformatics analysis revealed close homolog of LI (CHL1) as a potential target of miR-182. Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines. miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3?-untranslated region (3?-UTR). Downregulation of miR-182 suppressed growth and invasion of PTC cells. Silencing of CHL1 counteracted the effects of miR-182 suppression, while its overexpression mimicked these effects. Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC.

  8. Neutron and Nuclear Science Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publications Recent publications related to neutron and nuclear science at LANSCE. Neutron and Nuclear Science Publications Chi-Nu Publications DANCE Publications GEANIE Publications ICE House and ICE II Publications (n,z) Publications Neutron Radiography Publications SPIDER Publications Target 2 Publications TPC Publications Links Publications/Media Neutron and Nuclear Science News Profiles Events at LANSCE LANL Research Libary

  9. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

    SciTech Connect (OSTI)

    Kim, Byeong-Moo; Choi, Michael Y.

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

  10. NuMI proton kicker extraction magnet termination resistor system

    SciTech Connect (OSTI)

    Reeves, S.R.; Jensen, C.C.; /Fermilab

    2005-05-01

    The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.