National Library of Energy BETA

Sample records for detectable activity mda

  1. Excavation of MDA B

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MDA B Excavation Excavation of MDA B In a Recovery Act project, workers excavated a waste disposal site known as Material Disposal Area B (MDA-B). August 1, 2013 In a Recovery Act project at Los Alamos National Laboratory, workers excavated a waste disposal site known as Material Disposal Area B (MDA-B). A dome was erected over material disposal area to protect air quality during excavation. LANL completed excavation of MDA-B in September 2011 thanks to American Recovery and Reinvestment Act

  2. Interactive Activity Detection Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Activity Detection Tools Interactive Activity Detection Tools Tools for detecting specified activities in video data provide a key intelligence capability. High numbers of false alarms, however, reduce tool effectiveness and analyst patience. User feedback reduces false alarms * This project will reduce the number of false alarms generated by activity detection tools (including single vehicle start / stop, multi-vehicle meetings and coordinated driving patterns) by exploiting user feedback in a

  3. Excavation of MDA B

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    workers excavated a waste disposal site known as Material Disposal Area B (MDA-B). A dome was erected over material disposal area to protect air quality during excavation. LANL...

  4. UV Decontamination of MDA Reagents for Single Cell Genomics

    SciTech Connect (OSTI)

    Lee, Janey; Tighe, Damon; Sczyrba, Alexander; Malmatrom, Rex; Clingenpeel, Scott; Malfatti, Stephanie; Rinke, Christian; Wang, Zhong; Stepanauskas, Ramunas; Cheng, Jan-Fang; Woyke, Tanja

    2011-03-18

    Single cell genomics, the amplification and sequencing of genomes from single cells, can provide a glimpse into the genetic make-up and thus life style of the vast majority of uncultured microbial cells, making it an immensely powerful and increasingly popular tool. This is accomplished by use of multiple displacement amplification (MDA), which can generate billions of copies of a single bacterial genome producing microgram-range DNA required for shotgun sequencing. Here, we address a key challenge inherent to this approach and propose a solution for the improved recovery of single cell genomes. While DNA-free reagents for the amplification of a single cell genome are a prerequisite for successful single cell sequencing and analysis, DNA contamination has been detected in various reagents, which poses a considerable challenge. Our study demonstrates the effect of UV irradiation in efficient elimination of exogenous contaminant DNA found in MDA reagents, while maintaining Phi29 activity. Consequently, we also find that increased UV exposure to Phi29 does not adversely affect genome coverage of MDA amplified single cells. While additional challenges in single cell genomics remain to be resolved, the proposed methodology is relatively quick and simple and we believe that its application will be of high value for future single cell sequencing projects.

  5. Energy Detectives (3 Activities)

    Broader source: Energy.gov [DOE]

    Students explore the classroom as they look and feel for signs of energy. They record the ways they use energy throughout a typical day in an energy detective journal.

  6. The synchronous active neutron detection assay system

    SciTech Connect (OSTI)

    Pickrell, M.M.; Kendall, P.K.

    1994-08-01

    We have begun to develop a novel technique for active neutron assay of fissile material in spent nuclear fuel. This approach will exploit a 14-MeV neutron generator developed by Schlumberger. The technique, termed synchronous active neutron detection (SAND), follows a method used routinely in other branches of physics to detect very small signals in presence of large backgrounds. Synchronous detection instruments are widely available commercially and are termed ``lock-in`` amplifiers. We have implemented a digital lock-in amplifier in conjunction with the Schlumberger neutron generator to explore the possibility of synchronous detection with active neutrons. The Schlumberger system can operate at up to a 50% duty factor, in effect, a square wave of neutron yield. Results are preliminary but promising. The system is capable of resolving the fissile material contained in a small fraction of the fuel rods in a cold fuel assembly; it also appears resilient to background neutron interference. The interrogating neutrons appear to be non-thermal and penetrating. Work remains to fully explore relevant physics and optimize instrument design.

  7. Analyte detection using an active assay

    DOE Patents [OSTI]

    Morozov, Victor; Bailey, Charles L.; Evanskey, Melissa R.

    2010-11-02

    Analytes using an active assay may be detected by introducing an analyte solution containing a plurality of analytes to a lacquered membrane. The lacquered membrane may be a membrane having at least one surface treated with a layer of polymers. The lacquered membrane may be semi-permeable to nonanalytes. The layer of polymers may include cross-linked polymers. A plurality of probe molecules may be arrayed and immobilized on the lacquered membrane. An external force may be applied to the analyte solution to move the analytes towards the lacquered membrane. Movement may cause some or all of the analytes to bind to the lacquered membrane. In cases where probe molecules are presented, some or all of the analytes may bind to probe molecules. The direction of the external force may be reversed to remove unbound or weakly bound analytes. Bound analytes may be detected using known detection types.

  8. A Multidisciplinary Approach To Detect Active Pathways For Magma...

    Open Energy Info (EERE)

    Multidisciplinary Approach To Detect Active Pathways For Magma Migration And Eruption At Mt Etna (Sicily, Italy) Before The 2001 And 2002-2003 Eruptions Jump to: navigation, search...

  9. SNM detection by active muon interrogation

    SciTech Connect (OSTI)

    Jason, Andrew J; Miyadera, Haruo; Turchi, Peter J

    2010-01-01

    Muons are charged particles with mass between the electron and proton and can be produced indirectly through pion decay by interaction of a charged-particle beam with a target. There are several distinct features of the muon interaction with matter attractive as a probe for detection of SNM at moderate ranges. These include muon penetration of virtually any amount of material without significant nuclear interaction until stopped by ionization loss in a short distance. When stopped, high-energy penetrating x-rays (in the range of 6 MeV for uranium,) unique to isotopic composition are emitted in the capture process. The subsequent interaction with the nucleus produces additional radiation useful in assessing SNM presence. A focused muon beam can be transported through the atmosphere, at a range limited mainly by beam-size growth through scattering. A muonbeam intensity of > 10{sup 9} /second is required for efficient interrogation and, as in any other technique, dose limits are to be respected. To produce sufficient muons a high-energy (threshold {approx}140 MeV) high-intensity (<1 mA) proton or electron beam is needed implying the use of a linear accelerator to bombard a refractory target. The muon yield is fractionally small, with large angle and energy dispersion, so that efficient collection is necessary in all dimensions of phase space. To accomplish this Los Alamos has proposed a magnetic collection system followed by a unique linear accelerator that provides the requisite phase-space bunching and allows an energy sweep to successively stop muons throughout a large structure such as a sea-going vessel. A possible maritime application would entail fitting the high-gradient accelerators on a large ship with a helicopter-borne detection system. We will describe our experimental results for muon effects and particle collection along with our current design and program for a muon detection system.

  10. 2011-07 "Maximum Utilization of WIPP by Increasing MDA G TRU...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    7 "Maximum Utilization of WIPP by Increasing MDA G TRU Shipments" 2011-07 "Maximum Utilization of WIPP by Increasing MDA G TRU Shipments" The intent of this recommendation is to ...

  11. 2008-10 "Independent Review of the MDA G CME Report by DOE Office...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    0 "Independent Review of the MDA G CME Report by DOE Office of Groundwater and Soil Remediation" 2008-10 "Independent Review of the MDA G CME Report by DOE Office of Groundwater and ...

  12. Electrochemical Proteolytic Beacon for Detection of Matrix Metalloproteinase Activities

    SciTech Connect (OSTI)

    Liu, Guodong; Wang, Jun; Wunschel, David S.; Lin, Yuehe

    2006-09-27

    This communication describes a novel method for detecting of matrix metalloproteinase-7 activity using a peptide substrate labeled with a ferrocene reporter. The substrate serves as a selective ‘electrochemical proteolytic beacon’ (EPB) for this metalloproteinase. The EPB is immobilized on a gold electrode surface to enable ‘on-off’ electrochemical signaling capability for uncleaved and cleaved events. The EPB is efficiently and selectively cleaved by MMP-7 as measured by the rate of decrease in redox current of ferrocene. Direct transduction of a signal corresponding to peptide cleavage events into an electronic signal thus provides a simple, sensitive route for detecting the MMP activity. The new method allows for identification of the activity of MMP-7 in concentrations as low as 3.4 pM. The concept can be extended to design multiple peptide substrate labeled with different electroactive reporters for assaying multiple MMPs activities.

  13. The synchronous active neutron detection system for spent fuel assay

    SciTech Connect (OSTI)

    Pickrell, M.M.; Kendall, P.K.

    1994-10-01

    The authors have begun to develop a novel technique for active neutron assay of fissile material in spent nuclear fuel. This approach will exploit the unique operating features of a 14-MeV neutron generator developed by Schlumberger. This generator and a novel detection system will be applied to the direct measurement of the fissile material content in spent fuel in place of the indirect measures used at present. The technique they are investigating is termed synchronous active neutron detection (SAND). It closely follows a method that has been used routinely in other branches of physics to detect very small signals in the presence of large backgrounds. Synchronous detection instruments are widely available commercially and are termed {open_quotes}lock-in{close_quotes} amplifiers. The authors have implemented a digital lock-in amplifier in conjunction with the Schlumberger neutron generator to explore the possibility of synchronous detection with active neutrons. This approach is possible because the Schlumberger system can operate at up to a 50% duty factor, in effect, a square wave of neutron yield. The results to date are preliminary but quite promising. The system is capable of resolving the fissile material contained in a small fraction of the fuel rods in a cold fuel assembly. It also appears to be quite resilient to background neutron interference. The interrogating neutrons appear to be nonthermal and penetrating. Although a significant amount of work remains to fully explore the relevant physics and optimize the instrument design, the underlying concept appears sound.

  14. Regulation of MDA-MB-231 cell proliferation by GSK-3? involves epigenetic modifications under high glucose conditions

    SciTech Connect (OSTI)

    Gupta, Chanchal; Kaur, Jasmine; Tikoo, Kulbhushan

    2014-05-15

    Hyperglycemia is a critical risk factor for development and progression of breast cancer. We have recently reported that high glucose induces phosphorylation of histone H3 at Ser 10 as well as de-phosphorylation of GSK-3? at Ser 9 in MDA-MB-231 cells. Here, we elucidate the mechanism underlying hyperglycemia-induced proliferation in MDA-MB-231 breast cancer cells. We provide evidence that hyperglycemia led to increased DNA methylation and DNMT1 expression in MDA-MB-231 cells. High glucose condition led to significant increase in the expression of PCNA, cyclin D1 and decrease in the expression of PTPN 12, p21 and PTEN. It also induced hypermethylation of DNA at the promoter region of PTPN 12, whereas hypomethylation at Vimentin and Snail. Silencing of GSK-3? by siRNA prevented histone H3 phosphorylation and reduced DNMT1 expression. We show that chromatin obtained after immunoprecipitation with phospho-histone H3 was hypermethylated under high glucose condition, which indicates a cross-talk between DNA methylation and histone H3 phosphorylation. ChIP-qPCR analysis revealed up-regulation of DNMT1 and metastatic genes viz. Vimentin, Snail and MMP-7 by phospho-histone H3, which were down-regulated upon GSK-3? silencing. To the best of our knowledge, this is the first report which shows that interplay between GSK-3? activation, histone H3 phosphorylation and DNA methylation directs proliferation of breast cancer cells. - Highlights: • High glucose induces phosphorylation of histone H3 and dephosphorylation of GSK-3?. • Moreover, hyperglycemia also leads to increased DNA methylation in MDA-MB-231 cells. • Inhibition of GSK-3? prevented histone H3 phosphorylation and reduced DNMT1 levels. • Interplay exists between GSK-3?, histone H3 phosphorylation and DNA methylation.

  15. Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces

    DOE Patents [OSTI]

    Salafsky, Joshua S.; Eisenthal, Kenneth B.

    2005-10-11

    This invention provides methods of detecting molecules at an interface, which comprise labeling the molecules with a second harmonic-active moiety and detecting the labeled molecules at the interface using a surface selective technique. The invention also provides methods for detecting a molecule in a medium and for determining the orientation of a molecular species within a planar surface using a second harmonic-active moiety and a surface selective technique.

  16. 2011-07 "Maximum Utilization of WIPP by Increasing MDA G TRU Shipments" |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 7 "Maximum Utilization of WIPP by Increasing MDA G TRU Shipments" 2011-07 "Maximum Utilization of WIPP by Increasing MDA G TRU Shipments" The intent of this recommendation is to ensure optimization of WIPP shipment schedules while helping to keep commitments to Consent Order milestones at MDA-G. Rec 2011-07 - July 27, 2011 (78.0

  17. Rapid Detection of Biological and Chemical Threat Agents Using Physical Chemistry, Active Detection, and Computational Analysis

    SciTech Connect (OSTI)

    Chung, Myung; Dong, Li; Fu, Rong; Liotta, Lance; Narayanan, Aarthi; Petricoin, Emanuel; Ross, Mark; Russo, Paul; Zhou, Weidong; Luchini, Alessandra; Manes, Nathan; Chertow, Jessica; Han, Suhua; Kidd, Jessica; Senina, Svetlana; Groves, Stephanie

    2007-01-01

    Basic technologies have been successfully developed within this project: rapid collection of aerosols and a rapid ultra-sensitive immunoassay technique. Water-soluble, humidity-resistant polyacrylamide nano-filters were shown to (1) capture aerosol particles as small as 20 nm, (2) work in humid air and (3) completely liberate their captured particles in an aqueous solution compatible with the immunoassay technique. The immunoassay technology developed within this project combines electrophoretic capture with magnetic bead detection. It allows detection of as few as 150-600 analyte molecules or viruses in only three minutes, something no other known method can duplicate. The technology can be used in a variety of applications where speed of analysis and/or extremely low detection limits are of great importance: in rapid analysis of donor blood for hepatitis, HIV and other blood-borne infections in emergency blood transfusions, in trace analysis of pollutants, or in search of biomarkers in biological fluids. Combined in a single device, the water-soluble filter and ultra-sensitive immunoassay technique may solve the problem of early “warning type” detection of aerosolized pathogens. These two technologies are protected with five patent applications and are ready for commercialization.

  18. detection

    National Nuclear Security Administration (NNSA)

    of 25 Million Grant to Improve Technological Capabilities for Detecting Nuclear Proliferation http:www.nnsa.energy.govmediaroompressreleasesncstateconsortium

  19. Detection of protease and protease activity using a single nanoscrescent SERS probe

    DOE Patents [OSTI]

    Liu, Gang L.; Ellman, Jonathan A.; Lee, Luke P.; Chen, Fanqing Frank

    2013-01-29

    This invention pertains to the in vitro detection of proteases using a single peptide-conjugate nanocrescent surface enhanced Raman scattering (SERS) probes with at least nanomolar sensitivity. The probe enables detection of proteolytic activity in extremely small volume and at low concentration. In certain embodiments the probes comprise an indicator for the detection of an active protease, where the indicator comprises a nanocrescent attached to a peptide, where said peptide comprises a recognition site for the protease and a Raman tag attached to the peptide.

  20. detection

    National Nuclear Security Administration (NNSA)

    of 25 Million Grant to Improve Technological Capabilities for Detecting Nuclear Proliferation http:nnsa.energy.govmediaroompressreleasesncstateconsortium

  1. Detect

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    coherent Raman scattering Standoff detection of physical and chemical signatures from manufacturing and concealed deployment Standoff high-selectivity spectroscopy of ...

  2. 2008-10 "Independent Review of the MDA G CME Report by DOE Office of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Groundwater and Soil Remediation" | Department of Energy 0 "Independent Review of the MDA G CME Report by DOE Office of Groundwater and Soil Remediation" 2008-10 "Independent Review of the MDA G CME Report by DOE Office of Groundwater and Soil Remediation" The intent of this recommendation is to perform an independent and informed review of the MDA G CME which can be referenced by LANL in their discussions with NMED during the NMED acceptance review. This independent

  3. 2011-09 "New Urgency for Increased TRU Shipments from MDA G" | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 9 "New Urgency for Increased TRU Shipments from MDA G" 2011-09 "New Urgency for Increased TRU Shipments from MDA G" The intent of this recommendation is to provide confidence to the Northern New Mexico communities that DOE is responding to the need to protect their health and safety. Rec 2011-09 - July 27, 2011 (80.7

  4. Baseline geochemistry of soil and bedrock Tshirege Member of the Bandelier Tuff at MDA-P

    SciTech Connect (OSTI)

    Warren, R.G.; McDonald, E.V.; Ryti, R.T.

    1997-08-01

    This report provides baseline geochemistry for soils (including fill), and for bedrock within three specific areas that are planned for use in the remediation of Material Disposal Area P (MDA-P) at Technical Area 16 (TA-16). The baseline chemistry includes leachable element concentrations for both soils and bedrock and total element concentrations for all soil samples and for two selected bedrock samples. MDA-P operated from the early 1950s to 1984 as a landfill for rubble and debris generated by the burning of high explosives (HE) at the TA-16 Burning Ground, HE-contaminated equipment and material, barium nitrate sand, building materials, and trash. The aim of this report is to establish causes for recognizable chemical differences between the background and baseline data sets. In many cases, the authors conclude that recognizable differences represent natural enrichments. In other cases, differences are best attributed to analytical problems. But most importantly, the comparison of background and baseline geochemistry demonstrates significant contamination for several elements not only at the two remedial sites near the TA-16 Burning Ground, but also within the entire region of the background study. This contamination is highly localized very near to the surface in soil and fill, and probably also in bedrock; consequently, upper tolerance limits (UTLs) calculated as upper 95% confidence limits of the 95th percentile are of little value and thus are not provided. This report instead provides basic statistical summaries and graphical comparisons for background and baseline samples to guide strategies for remediation of the three sites to be used in the restoration of MDA-P.

  5. Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents

    DOE Patents [OSTI]

    Wachter, Eric A.; Fisher, Walter G.; Dees, H. Craig

    2008-03-18

    A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method comprises the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention also provides a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

  6. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

    DOE Patents [OSTI]

    Wachter, E.A.; Fisher, W.G.; Dees, H.C.

    1998-11-10

    A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent. 13 figs.

  7. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

    DOE Patents [OSTI]

    Wachter, Eric A.; Fisher, Walter G.; Dees, H. Craig

    1998-01-01

    A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

  8. Photo-activated luminescence sensor and method of detecting trichloroethylene and related volatile organochloride compounds

    DOE Patents [OSTI]

    Dinh, T.V.

    1996-06-11

    A sensor for detecting trichloroethylene and related volatile organochloride compounds uses a photo-activator that produces a photo-product complex with the contaminant. Characteristics of the light emitted from the complex will indicate the presence of the contaminant. A probe containing the photo-activator has an excitation light interface and a contaminant interface. One particular embodiment uses a porous membrane as the contaminant interface, so that the contaminant can migrate there through to the photo-activator and thereby form the complex. 23 figs.

  9. Photo-activated luminescence sensor and method of detecting trichloroethylene and related volatile organochloride compounds

    DOE Patents [OSTI]

    Dinh, Tuan V.

    1996-01-01

    A sensor for detecting trichloroethylene and related volatile organochloride compounds uses a photo-activator that produces a photo-product complex with the contaminant. Characteristics of the light emitted from the complex will indicate the presence of the contaminant. A probe containing the photo-activator has an excitation light interface and a contaminant interface. One particular embodiment uses a porous membrane as the contaminant interface, so that the contaminant can migrate therethrough to the photo-activator and thereby form the complex.

  10. Methods, microfluidic devices, and systems for detection of an active enzymatic agent

    DOE Patents [OSTI]

    Sommer, Gregory J; Hatch, Anson V; Singh, Anup K; Wang, Ying-Chih

    2014-10-28

    Embodiments of the present invention provide methods, microfluidic devices, and systems for the detection of an active target agent in a fluid sample. A substrate molecule is used that contains a sequence which may cleave in the presence of an active target agent. A SNAP25 sequence is described, for example, that may be cleaved in the presence of Botulinum Neurotoxin. The substrate molecule includes a reporter moiety. The substrate molecule is exposed to the sample, and resulting reaction products separated using electrophoretic separation. The elution time of the reporter moiety may be utilized to identify the presence or absence of the active target agent.

  11. Chemical hazard evaluation of material disposal area (MDA) B closure project

    SciTech Connect (OSTI)

    Laul, Jagdish C

    2010-04-19

    TA-21, MDA-B (NES) is the 'contaminated dump,' landfill with radionuclides and chemicals from process waste disposed in 1940s. This paper focuses on chemical hazard categorization and hazard evaluation of chemicals of concern (e.g., peroxide, beryllium). About 170 chemicals were disposed in the landfill. Chemicals included products, unused and residual chemicals, spent, waste chemicals, non-flammable oils, mineral oil, etc. MDA-B was considered a High hazard site. However, based on historical records and best engineering judgment, the chemical contents are probably at best 5% of the chemical inventory. Many chemicals probably have oxidized, degraded or evaporated for volatile elements due to some fire and limited shelf-life over 60 yrs, which made it possible to downgrade from High to Low chemical hazard site. Knowing the site history and physical and chemical properties are very important in characterizing a NES site. Public site boundary is only 20 m, which is a major concern. Chemicals of concern during remediation are peroxide that can cause potential explosion and beryllium exposure due to chronic beryllium disease (CBD). These can be prevented or mitigated using engineering control (EC) and safety management program (SMP) to protect the involved workers and public.

  12. Innovative high pressure gas MEM's based neutron detector for ICF and active SNM detection.

    SciTech Connect (OSTI)

    Martin, Shawn Bryan; Derzon, Mark Steven; Renzi, Ronald F.; Chandler, Gordon Andrew

    2007-12-01

    An innovative helium3 high pressure gas detection system, made possible by utilizing Sandia's expertise in Micro-electrical Mechanical fluidic systems, is proposed which appears to have many beneficial performance characteristics with regards to making these neutron measurements in the high bremsstrahlung and electrical noise environments found in High Energy Density Physics experiments and especially on the very high noise environment generated on the fast pulsed power experiments performed here at Sandia. This same system may dramatically improve active WMD and contraband detection as well when employed with ultrafast (10-50 ns) pulsed neutron sources.

  13. Estimation of the Performance of Multiple Active Neutron Interrogation Signatures for Detecting Shielded HEU

    SciTech Connect (OSTI)

    David L. Chichester; Scott J. Thompson; Scott M. Watson; James T. Johnson; Edward H. Seabury

    2012-10-01

    A comprehensive modeling study has been carried out to evaluate the utility of multiple active neutron interrogation signatures for detecting shielded highly enriched uranium (HEU). The modeling effort focused on varying HEU masses from 1 kg to 20 kg; varying types of shields including wood, steel, cement, polyethylene, and borated polyethylene; varying depths of the HEU in the shields, and varying engineered shields immediately surrounding the HEU including steel, tungsten, and cadmium. Neutron and gamma-ray signatures were the focus of the study and false negative detection probabilities versus measurement time were used as a performance metric. To facilitate comparisons among different approaches an automated method was developed to generate receiver operating characteristic (ROC) curves for different sets of model variables for multiple background count rate conditions. This paper summarizes results or the analysis, including laboratory benchmark comparisons between simulations and experiments. The important impact engineered shields can play towards degrading detectability and methods for mitigating this will be discussed.

  14. COLA. III. RADIO DETECTION OF ACTIVE GALACTIC NUCLEUS IN COMPACT MODERATE LUMINOSITY INFRARED GALAXIES

    SciTech Connect (OSTI)

    Parra, R.; Conway, J. E.; Aalto, S.; Appleton, P. N.; Norris, R. P.; Pihlstroem, Y. M.; Kewley, L. J.

    2010-09-01

    We present results from 4.8 GHz Very Large Array (VLA) and global very long baseline interferometry (VLBI) observations of the northern half of the moderate FIR luminosity (median L{sub IR} = 10{sup 11.01} L{sub sun}) COLA sample of star-forming galaxies. VLBI sources are detected in a high fraction (20/90) of the galaxies observed. The radio luminosities of these cores ({approx}10{sup 21} W Hz{sup -1}) are too large to be explained by radio supernovae or supernova remnants and we argue that they are instead powered by active galactic nuclei (AGNs). These sub-parsec scale radio cores are preferentially detected toward galaxies whose VLA maps show bright 100-500 parsec scale nuclear radio components. Since these latter structures tightly follow the FIR to radio-continuum correlation for star formation, we conclude that the AGN-powered VLBI sources are associated with compact nuclear starburst environments. The implications for possible starburst-AGN connections are discussed. The detected VLBI sources have a relatively narrow range of radio luminosity consistent with models in which intense compact Eddington-limited starbursts regulate the gas supply onto a central supermassive black hole. The high incidence of AGN radio cores in compact starbursts suggests little or no delay between the starburst phase and the onset of AGN activity.

  15. Optically Detected Magnetic Resonance and Thermal Activation Spectroscopy Study of Organic Semiconductors

    SciTech Connect (OSTI)

    Chang-Hwan Kim

    2003-12-12

    Organic electronic materials are a new class of emerging materials. Organic light emitting devices (OLEDs) are the most promising candidates for future flat panel display technologies. The photophysical characterization is the basic research step one must follow to understand this new class of materials and devices. The light emission properties are closely related to the transport properties of these materials. The objective of this dissertation is to probe the relation between transport and photophysical properties of organic semiconductors. The transport characteristics were evaluated by using thermally stimulated current and thermally stimulated luminescence techniques. The photoluminescence detected magnetic resonance and photoluminescence quantum yield studies provide valuable photophysical information on this class of materials. OLEDs are already in the market. However, detailed studies on the degradation mechanisms are still lacking. Since both optically detected magnetic resonance and thermal activation spectroscopy probe long-lived defect-related states in organic semiconductors, the combined study generates new insight on the OLED operation and degradation mechanisms.

  16. Photon-axion mixing within the jets of active galactic nuclei and prospects for detection

    SciTech Connect (OSTI)

    Harris, J.; Chadwick, P.M. E-mail: p.m.chadwick@durham.ac.uk

    2014-10-01

    Very high energy ?-ray observations of distant active galactic nuclei (AGN) generally result in higher fluxes and harder spectra than expected, resulting in some tension with the level of the extragalactic background light (EBL). If hypothetical axions or axion-like particles (ALPs) were to exist, this tension could be relieved since the oscillation of photons to ALPs would mitigate the effects of EBL absorption and lead to softer inferred intrinsic AGN spectra. In this paper we consider the effect of photon-ALP mixing on observed spectra, including the photon-ALP mixing that would occur within AGN jets. We then simulate observations of three AGN with the Cherenkov Telescope Array (CTA), a next generation ?-ray telescope, to determine its prospects for detecting the signatures of photon-ALP mixing on the spectra. We conclude that prospects for CTA detecting these signatures or else setting limits on the ALP parameter space are quite promising. We find that prospects are improved if photon-ALP mixing within the jet is properly considered and that the best target for observations is PKS 2155-304.

  17. Passive and Active Neutron Matrix Correction for Heterogeneous Distributions Utilizing the Neutron Imaging Technique

    SciTech Connect (OSTI)

    Villani, M.F.; Croft, St.; Alvarez, E.; Wilkins, C.G.; Stamp, D.; Fisher, J.; Ambrifi, A.; Simone, G.; Bourva, L.C.

    2008-07-01

    Classical Non-Destructive Assay (NDA) Passive Neutron Coincidence Counting (PNCC) and Differential Die-Away (DDA) active neutron interrogation techniques [1, 2] are well suited for determining the gross matrix correction factors for homogenous mass distributions of Special Nuclear Material (SNM) within an interfering waste drum matrix. These measured passive and active matrix correction factors are crucial in quantifying the SNM mass, associated Total Measurement Uncertainty (TMU), and Minimum Detectable Activity (MDA) within the drum. When heterogeneous SNM mass distributions are encountered, the measured SNM mass, TMU and MDA biases introduced may be 100%, or greater, especially for dense hydrogenous matrices. The standard matrix correction factors can be adjusted if a coarse spatial image of the SNM mass, relative to the matrix, is available. The image can then be analyzed to determine the spatially-adjusted, matrix correction factors case by case. This image analysis approach was accomplished by modifying the standard Passive-Active Neutron (PAN) counter design [3] to accommodate a unique data acquisition architecture that supports a newly developed image acquisition and analysis application called the Neutron Imaging Technique (NIT). The NIT functionality supports both PNCC and DDA acquisition and analysis modes and exploits the symmetry between a stored set of factory acquired NIT images with those from the unknown PAN assay. The NIT result is then an adjustment to the classical correction factor reducing, if not removing, the SNM mass bias and revealing the true TMU and MDA values. In this paper we describe the NIT for the PAN design from the software and algorithmic perspectives and how this technique accommodates waste matrix drums that are difficult, from the classical standpoint, if not impossible, to extract meaningful SNM mass, TMU and MDA results. (authors)

  18. Sprague-Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA)

    SciTech Connect (OSTI)

    Fonsart, Julien; Menet, Marie-Claude; Debray, Marcel; Hirt, Deborah; Noble, Florence; Scherrmann, Jean-Michel; Decleves, Xavier

    2009-12-15

    The use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) has increased in recent years; it can lead to life-threatening hyperthermia and serotonin syndrome. Human and rodent males appear to be more sensitive to acute toxicity than are females. MDMA is metabolized to five main metabolites by the enzymes CYP1A2, CYP2D and COMT. Little is presently known about sex-dependent differences in the pharmacokinetics of MDMA and its metabolites. We therefore analyzed MDMA disposition in male and female rats by measuring the plasma and urine concentrations of MDMA and its metabolites using a validated LC-MS method. MDA AUC{sub last} and C{sub max} were 1.6- to 1.7-fold higher in males than in females given MDMA (5 mg/kg sc), while HMMA C{sub max} and AUC{sub last} were 3.2- and 3.5-fold higher, respectively. MDMA renal clearance was 1.26-fold higher in males, and that of MDA was 2.2-fold higher. MDMA AUC{sub last} and t{sub 1/2} were 50% higher in females given MDMA (1 mg/kg iv). MDA C{sub max} and AUC{sub last} were 75-82% higher in males, with a 2.8-fold higher metabolic index. Finally, the AUC{sub last} of MDA was 0.73-fold lower in males given 1 mg/kg iv MDA. The volumes of distribution of MDMA and MDA at steady-state were similar in the two sexes. These data strongly suggest that differences in the N-demethylation of MDMA to MDA are major influences on the MDMA and MDA pharmacokinetics in male and female rats. Hence, males are exposed to significantly more toxic MDA, which could explain previously reported sexual dysmorphism in the acute effects and toxicity of MDMA in rats.

  19. Gamma/neutron time-correlation for special nuclear material detection – Active stimulation of highly enriched uranium

    SciTech Connect (OSTI)

    Paff, Marc G.; Monterial, Mateusz; Marleau, Peter; Kiff, Scott; Nowack, Aaron; Clarke, Shaun D.; Pozzi, Sara A.

    2014-06-21

    A series of simulations and experiments were undertaken to explore and evaluate the potential for a novel new technique for fissile material detection and characterization, the timecorrelated pulse-height (TCPH) method, to be used concurrent with active stimulation of potential nuclear materials. In previous work TCPH has been established as a highly sensitive method for the detection and characterization of configurations of fissile material containing Plutonium in passive measurements. By actively stimulating fission with the introduction of an external radiation source, we have shown that TCPH is also an effective method of detecting and characterizing configurations of fissile material containing Highly Enriched Uranium (HEU). The TCPH method is shown to be robust in the presence of the proper choice of external radiation source. An evaluation of potential interrogation sources is presented.

  20. Gamma/neutron time-correlation for special nuclear material detection – Active stimulation of highly enriched uranium

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Paff, Marc G.; Monterial, Mateusz; Marleau, Peter; Kiff, Scott; Nowack, Aaron; Clarke, Shaun D.; Pozzi, Sara A.

    2014-06-21

    A series of simulations and experiments were undertaken to explore and evaluate the potential for a novel new technique for fissile material detection and characterization, the timecorrelated pulse-height (TCPH) method, to be used concurrent with active stimulation of potential nuclear materials. In previous work TCPH has been established as a highly sensitive method for the detection and characterization of configurations of fissile material containing Plutonium in passive measurements. By actively stimulating fission with the introduction of an external radiation source, we have shown that TCPH is also an effective method of detecting and characterizing configurations of fissile material containing Highlymore » Enriched Uranium (HEU). The TCPH method is shown to be robust in the presence of the proper choice of external radiation source. An evaluation of potential interrogation sources is presented.« less

  1. Improved Design of Active Pixel CMOS Sensors for Charged Particle Detection

    SciTech Connect (OSTI)

    Deptuch, Grzegorz

    2007-11-12

    The Department of Energy (DOE) nuclear physics program requires developments in detector instrumentation electronics with improved energy, position and timing resolution, sensitivity, rate capability, stability, dynamic range, and background suppression. The current Phase-I project was focused on analysis of standard-CMOS photogate Active Pixel Sensors (APS) as an efficient solution to this challenge. The advantages of the CMOS APS over traditional hybrid approaches (i.e., separate detection regions bump-bonded to readout circuits) include greatly reduced cost, low power and the potential for vastly larger pixel counts and densities. However, challenges remain in terms of the signal-to-noise ratio (SNR) and readout speed (currently on the order of milliseconds), which is the major problem for this technology. Recent work has shown that the long readout time for photogate APS is due to the presence of (interface) traps at the semiconductor-oxide interface. This Phase-I work yielded useful results in two areas: (a) Advanced three-dimensional (3D) physics-based simulation models and simulation-based analysis of the impact of interface trap density on the transient charge collection characteristics of existing APS structures; and (b) Preliminary analysis of the feasibility of an improved photogate pixel structure (i.e., new APS design) with an induced electric field under the charge collecting electrode to enhance charge collection. Significant effort was dedicated in Phase-I to the critical task of implementing accurate interface trap models in CFDRC's NanoTCAD 3D semiconductor device-physics simulator. This resulted in validation of the new NanoTCAD models and simulation results against experimental (published) data, within the margin of uncertainty associated with obtaining device geometry, material properties, and experimentation details. Analyses of the new, proposed photogate APS design demonstrated several promising trends.

  2. Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: Role of ?-catenin/connexin43 association

    SciTech Connect (OSTI)

    Talhouk, Rabih S.; Fares, Mohamed-Bilal; Rahme, Gilbert J.; Hariri, Hanaa H.; Rayess, Tina; Dbouk, Hashem A.; Bazzoun, Dana; Al-Labban, Dania; El-Sabban, Marwan E.

    2013-12-10

    Connexins (Cx), gap junction (GJ) proteins, are regarded as tumor suppressors, and Cx43 expression is often down regulated in breast tumors. We assessed the effect of Cx43 over-expression in 2D and 3D cultures of two breast adenocarcinoma cell lines: MCF-7 and MDA-MB-231. While Cx43 over-expression decreased proliferation of 2D and 3D cultures of MCF-7 by 56% and 80% respectively, MDA-MB-231 growth was not altered in 2D cultures, but exhibited 35% reduction in 3D cultures. C-terminus truncated Cx43 did not alter proliferation. Untransfected MCF-7 cells formed spherical aggregates in 3D cultures, and MDA-MB-231 cells formed stellar aggregates. However, MCF-7 cells over-expressing Cx43 formed smaller sized clusters and Cx43 expressing MDA-MB-231 cells lost their stellar morphology. Extravasation ability of both MCF-7 and MDA-MB-231 cells was reduced by 60% and 30% respectively. On the other hand, silencing Cx43 in MCF10A cells, nonneoplastic human mammary cell line, increased proliferation in both 2D and 3D cultures, and disrupted acinar morphology. Although Cx43 over-expression did not affect total levels of ?-catenin, ?-catenin and ZO-2, it decreased nuclear levels of ?-catenin in 2D and 3D cultures of MCF-7 cells, and in 3D cultures of MDA-MB-231 cells. Cx43 associated at the membrane with ?-catenin, ?-catenin and ZO-2 in 2D and 3D cultures of MCF-7 cells, and only in 3D conditions in MDA-MB-231 cells. This study suggests that Cx43 exerts tumor suppressive effects in a context-dependent manner where GJ assembly with ?-catenin, ?-catenin and ZO-2 may be implicated in reducing growth rate, invasiveness, and, malignant phenotype of 2D and 3D cultures of MCF-7 cells, and 3D cultures of MDA-MB-231 cells, by sequestering ?-catenin away from nucleus. - Highlights: • Cx43 over-expressing MCF-7 and MDA-MB-231 were grown in 2D and 3D cultures. • Proliferation and growth morphology were affected in a context dependent manner. • Extravasation ability of both MCF-7 and MDA

  3. Prolactin receptor attenuation induces zinc pool redistribution through ZnT2 and decreases invasion in MDA-MB-453 breast cancer cells

    SciTech Connect (OSTI)

    Bostanci, Zeynep; Alam, Samina; Soybel, David I.; Kelleher, Shannon L.

    2014-02-15

    Prolactin receptor (PRL-R) activation regulates cell differentiation, proliferation, cell survival and motility of breast cells. Prolactin (PRL) and PRL-R over-expression are strongly implicated in breast cancer, particularly contributing to tumor growth and invasion in the more aggressive estrogen-receptor negative (ER?) disease. PRL-R antagonists have been suggested as potential therapeutic agents; however, mechanisms through which PRL-R antagonists exert their actions are not well-understood. Zinc (Zn) is a regulatory factor for over 10% of the proteome, regulating critical cell processes such as proliferation, cell signaling, transcription, apoptosis and autophagy. PRL-R signaling regulates Zn metabolism in breast cells. Herein we determined effects of PRL-R attenuation on cellular Zn metabolism and cell function in a model of ER-, PRL-R over-expressing breast cancer cells (MDA-MB-453). PRL-R attenuation post-transcriptionally increased ZnT2 abundance and redistributed intracellular Zn pools into lysosomes and mitochondria. ZnT2-mediated lysosomal Zn sequestration was associated with reduced matrix metalloproteinase 2 (MMP-2) activity and decreased invasion. ZnT2-mediated Zn accumulation in mitochondria was associated with increased mitochondrial oxidation. Our results suggest that PRL-R antagonism in PRL-R over-expressing breast cancer cells may reduce invasion through the redistribution of intracellular Zn pools critical for cellular function. - Highlights: • PRL-R attenuation increased ZnT2 expression. • PRL-R attenuation increased lysosomal and mitochondrial Zn accumulation. • PRL-R attenuation decreased MMP-2 and invasion. • PRL-R antagonists may modulate lysosomal and mitochondrial Zn pools.

  4. Detection of Hydrogen Spillover in Palladium-Modified Activated Carbon Fibers During Hydrogen Adsorption

    SciTech Connect (OSTI)

    Contescu, Cristian I; Brown, Craig; Liu, Yun; Bhat, Vinay V; Gallego, Nidia C

    2009-01-01

    Palladium-modified activated carbon fibers (Pd-ACF) are being evaluated for adsorptive hydrogen storage at near-ambient conditions because of their enhanced hydrogen uptake in comparison to Pd-free activated carbon fibers (ACF). The net uptake enhancement (at room temperature and 20 bar) is in excess of the amount corresponding to formation of Pd hydride, and is usually attributed to hydrogen spillover. In this paper, inelastic neutron scattering was used to demonstrate the formation of new C-H bonds in Pd-containing activated carbon fibers after exposure to hydrogen at 20 oC and 1.6 MPa, at the expense of physisorbed H2. This finding is a post-factum proof of the atomic nature of H species formed in presence of a Pd catalyst, and of their subsequent spillover and binding to the carbon support. Chemisorption of hydrogen may explain the reduction in hydrogen uptake from first to second adsorption cycle.

  5. Environmental assessment of the thermal neutron activation explosive detection system for concourse use at US airports

    SciTech Connect (OSTI)

    Jones, C.G.

    1990-08-01

    This document is an environmental assessment of a system designed to detect the presence of explosives in checked airline baggage or cargo. The system is meant to be installed at the concourse or lobby ticketing areas of US commercial airports and uses a sealed radioactive source of californium-252 to irradiate baggage items. The major impact of the use of this system arises from direct exposure of the public to scattered or leakage radiation from the source and to induced radioactivity in baggage items. Under normal operation and the most likely accident scenarios, the environmental impacts that would be created by the proposed licensing action would not be significant. 44 refs., 19 figs., 18 tabs.

  6. MDA0012.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Currents assets increased as prepaid expenses were up with a 80 million payment to Kaiser aluminum for a remarketing purchased power agreement. Deferred Credits Deferred...

  7. MDA0103.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Currents assets increased as prepaid expenses were up with a 80 million payment to Kaiser aluminum for a remarketing purchased power agreement. Deferred Credits Deferred...

  8. MDA - 0303.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for the same period in 2002. Operating Revenues Revenues from electricity sales and transmission of 1,713 million were down 14 million or one percent compared to the same period...

  9. MDA - 0203.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    California system. Operating Revenues Revenues from the sales of electricity and transmission of 1.727 billion were down 259 million or 13 percent compared to the same period...

  10. MDA - 0112.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    same period in 2000. Operating Revenues Revenues from the sales of electricity and transmission of 889 million were up 123 million compared to the same period of fiscal 2000....

  11. MDA - 0312.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    reduction). Operating Revenues Revenues of 790 million from electricity sales and transmission were down 84 million or 10 percent compared to the prior years first quarter....

  12. MDA - 0212.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for the same period in 2001. Operating Revenues Revenues from electricity sales and transmission of 874 million were down 15 million or two percent compared to the same period of...

  13. MDA - 0306.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in 2002. Operating Revenues Revenues of 2,437 million from electricity sales and transmission were down 65 million or 3 percent compared to the same period of fiscal 2002. The...

  14. MDA - 0206.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    period ended in 2001. Revenues from sales of electricity and U.S. T reasury credits for fish decreased, however purchased power and non-Federal projects expense decreased more....

  15. MDA0006.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    million, compared with 112 million for the same period a year ago. The increase of 132 million, or 118 percent, was primarily the result of increased discretionary power...

  16. ACTIVE GALACTIC NUCLEI IN GROUPS AND CLUSTERS OF GALAXIES: DETECTION AND HOST MORPHOLOGY

    SciTech Connect (OSTI)

    Arnold, Timothy J.; Martini, Paul; Mulchaey, John S.; Berti, Angela; Jeltema, Tesla E. E-mail: martini@astronomy.ohio-state.ed E-mail: tesla@ucolick.or

    2009-12-20

    The incidence and properties of active galactic nuclei (AGNs) in the field, groups, and clusters can provide new information about how these objects are triggered and fueled, similar to how these environments have been employed to study galaxy evolution. We have obtained new XMM-Newton observations of seven X-ray selected groups and poor clusters with 0.02 < z < 0.06 for comparison with previous samples that mostly included rich clusters and optically selected groups. Our final sample has ten groups and six clusters in this low-redshift range (split at a velocity dispersion of sigma = 500 kms{sup -1}). We find that the X-ray selected AGN fraction increases from f{sub A} (L{sub X} >= 10{sup 41}; M{sub R} <= M*{sub R} + 1) = 0.047{sup +0.023}{sub -0.016} in clusters to 0.091{sup +0.049}{sub -0.034} for the groups (85% significance), or a factor of 2, for AGN above an 0.3-8 keV X-ray luminosity of 10{sup 41}ergs{sup -1} hosted by galaxies more luminous than M*{sub R} + 1. The trend is similar, although less significant, for a lower-luminosity host threshold of M{sub R} = -20 mag. For many of the groups in the sample, we have also identified AGN via standard emission-line diagnostics and find that these AGNs are nearly disjoint from the X-ray selected AGN. Because there are substantial differences in the morphological mix of galaxies between groups and clusters, we have also measured the AGN fraction for early-type galaxies alone to determine if the differences are directly due to environment, or indirectly due to the change in the morphological mix. We find that the AGN fraction in early-type galaxies is also lower in clusters f{sub A,n>}={sub 2.5}(L{sub X} >= 10{sup 41}; M{sub R} <= M*{sub R} + 1) = 0.048{sup +0.028}{sub -0.019} compared to 0.119{sup +0.064}{sub -0.044} for the groups (92% significance), a result consistent with the hypothesis that the change in AGN fraction is directly connected to environment.

  17. Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells

    SciTech Connect (OSTI)

    Curry, Merril C.; Peters, Amelia A.; Kenny, Paraic A.; Roberts-Thomson, Sarah J.; Monteith, Gregory R.

    2013-05-10

    Highlights: •Some clinical breast cancers are associated with MCU overexpression. •MCU silencing did not alter cell death initiated with the Bcl-2 inhibitor ABT-263. •MCU silencing potentiated caspase-independent cell death initiated by ionomycin. •MCU silencing promoted ionomycin-mediated cell death without changes in bulk Ca{sup 2+}. -- Abstract: The mitochondrial calcium uniporter (MCU) transports free ionic Ca{sup 2+} into the mitochondrial matrix. We assessed MCU expression in clinical breast cancer samples using microarray analysis and the consequences of MCU silencing in a breast cancer cell line. Our results indicate that estrogen receptor negative and basal-like breast cancers are characterized by elevated levels of MCU. Silencing of MCU expression in the basal-like MDA-MB-231 breast cancer cell line produced no change in proliferation or cell viability. However, distinct consequences of MCU silencing were seen on cell death pathways. Caspase-dependent cell death initiated by the Bcl-2 inhibitor ABT-263 was not altered by MCU silencing; whereas caspase-independent cell death induced by the calcium ionophore ionomycin was potentiated by MCU silencing. Measurement of cytosolic Ca{sup 2+} levels showed that the promotion of ionomycin-induced cell death by MCU silencing occurs independently of changes in bulk cytosolic Ca{sup 2+} levels. This study demonstrates that MCU overexpression is a feature of some breast cancers and that MCU overexpression may offer a survival advantage against some cell death pathways. MCU inhibitors may be a strategy to increase the effectiveness of therapies that act through the induction of caspase-independent cell death pathways in estrogen receptor negative and basal-like breast cancers.

  18. Parametric Evaluation of Active Neutron Interrogation for the Detection of Shielded Highly-Enriched Uranium in the Field

    SciTech Connect (OSTI)

    D. L. Chcihester; E. H. Seabury; S. J. Thompson; R. R. C. Clement

    2011-10-01

    Parametric studies using numerical simulations are being performed to assess the performance capabilities and limits of active neutron interrogation for detecting shielded highly enriched uranium (HEU). Varying the shield material, HEU mass, HEU depth inside the shield, and interrogating neutron source energy, the simulations account for both neutron and photon emission signatures from the HEU with resolution in both energy and time. The results are processed to represent different irradiation timing schemes and several different classes of radiation detectors, and evaluated using a statistical approach considering signal intensity over background. This paper describes the details of the modeling campaign and some preliminary results, weighing the strengths of alternative measurement approaches for the different irradiation scenarios.

  19. Final report on passive and active low-frequency electromagnetic spectroscopy for airborne detection of underground facilities

    SciTech Connect (OSTI)

    SanFilipo, Bill

    2000-04-01

    The objective of this program is to perform research to advance the science in the application of both passive and active electromagnetic measurement techniques for the detection and spatial delineation of underground facilities. Passive techniques exploit the electromagnetic fields generated by electrical apparatus within the structure, including generators, motors, power distribution circuitry, as well as communications hardware and similar electronics equipment. Frequencies monitored are generally in the audio range (60-20,000 Hz), anticipating strong sources associated with normal AC power (i.e., 50 or 60 Hz and associated harmonics), and low frequency power from broad-band sources such as switching circuits. Measurements are made using receiver induction coils wired to electronics that digitize and record the voltage induced by the time varying magnetic fields. Active techniques employ electromagnetic field transmitters in the form of AC current carrying loops also in the audio frequency range, and receiving coils that measure the resultant time varying magnetic fields. These fields are perturbed from those expected in free space by any conductive material in the vicinity of the coils, including the ground, so that the total measured field is comprised of the primary free-space component and the secondary scattered component. The latter can be further delineated into an average background field (uniform conductive half-space earth) and anomalous field associated with heterogeneous zones in the earth, including both highly conductive objects such as metallic structures as well as highly resistive structures such as empty voids corresponding to rooms or tunnels. Work performed during Phase I included the development of the prototype GEM-2H instrumentation, collection of data at several test sites in the passive mode and a single site in the active mode, development of processing and interpretation software. The technical objectives of Phase II were to: (1

  20. Assessment of inhalation and ingestion doses from exposure to radon gas using passive and active detecting techniques

    SciTech Connect (OSTI)

    Ismail, A. H.; Jafaar, M. S.

    2011-07-01

    The aim of this study was to assess an environmental hazard of radon exhalation rate from the samples of soil and drinking water in selected locations in Iraqi Kurdistan, passive (CR-39NTDs) and active (RAD7) detecting techniques has been employed. Long and short term measurements of emitted radon concentrations were estimated for 124 houses. High and lower radon concentration in soil samples was in the cities of Hajyawa and Er. Tyrawa, respectively. Moreover, for drinking water, high and low radon concentration was in the cities of Similan and Kelak, respectively. A comparison between our results with that mentioned in international reports had been done. Average annual dose equivalent to the bronchial epithelium, stomach and whole body in the cities of Kelak and Similan are estimated, and it was varied from 0.04{+-}0.01 mSv to 0.547{+-}0.018 mSv, (2.832{+-}0.22)x10{sup -5} to (11.972{+-}2.09)x10{sup -5} mSv, and (0.056 {+-}0.01) x10{sup -5} to (0.239{+-}0.01)x10{sup -5} mSv, respectively. This indicated that the effects of dissolved radon on the bronchial epithelium are much than on the stomach and whole body. (authors)

  1. SGR J1550-5418 BURSTS DETECTED WITH THE FERMI GAMMA-RAY BURST MONITOR DURING ITS MOST PROLIFIC ACTIVITY

    SciTech Connect (OSTI)

    Van der Horst, A. J.; Finger, M. H. [Universities Space Research Association, NSSTC, Huntsville, AL 35805 (United States); Kouveliotou, C. [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Gorgone, N. M. [Connecticut College, New London, CT 06320 (United States); Kaneko, Y.; Goegues, E.; Lin, L. [Sabanc Latin-Small-Letter-Dotless-I University, Orhanl Latin-Small-Letter-Dotless-I -Tuzla, Istanbul 34956 (Turkey); Baring, M. G. [Department of Physics and Astronomy, Rice University, MS-108, P.O. Box 1892, Houston, TX 77251 (United States); Guiriec, S.; Bhat, P. N.; Chaplin, V. L.; Goldstein, A. [University of Alabama, Huntsville, CSPAR, Huntsville, AL 35805 (United States); Granot, J. [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel); Watts, A. L. [Astronomical Institute 'Anton Pannekoek', University of Amsterdam, Postbus 94249, 1090 GE Amsterdam (Netherlands); Bissaldi, E.; Gruber, D. [Max Planck Institute for Extraterrestrial Physics, Giessenbachstrasse, Postfach 1312, 85748 Garching (Germany); Gehrels, N.; Harding, A. K. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Gibby, M. H.; Giles, M. M., E-mail: A.J.VanDerHorst@uva.nl [Jacobs Technology, Inc., Huntsville, AL (United States); and others

    2012-04-20

    We have performed detailed temporal and time-integrated spectral analysis of 286 bursts from SGR J1550-5418 detected with the Fermi Gamma-ray Burst Monitor (GBM) in 2009 January, resulting in the largest uniform sample of temporal and spectral properties of SGR J1550-5418 bursts. We have used the combination of broadband and high time-resolution data provided with GBM to perform statistical studies for the source properties. We determine the durations, emission times, duty cycles, and rise times for all bursts, and find that they are typical of SGR bursts. We explore various models in our spectral analysis, and conclude that the spectra of SGR J1550-5418 bursts in the 8-200 keV band are equally well described by optically thin thermal bremsstrahlung (OTTB), a power law (PL) with an exponential cutoff (Comptonized model), and two blackbody (BB) functions (BB+BB). In the spectral fits with the Comptonized model, we find a mean PL index of -0.92, close to the OTTB index of -1. We show that there is an anti-correlation between the Comptonized E{sub peak} and the burst fluence and average flux. For the BB+BB fits, we find that the fluences and emission areas of the two BB functions are correlated. The low-temperature BB has an emission area comparable to the neutron star surface area, independent of the temperature, while the high-temperature BB has a much smaller area and shows an anti-correlation between emission area and temperature. We compare the properties of these bursts with bursts observed from other SGR sources during extreme activations, and discuss the implications of our results in the context of magnetar burst models.

  2. Laboratory and Field Testing of Commercially Available Detectors for the Identification of Chemicals of Interest in the Nuclear Fuel Cycle for the Detection of Undeclared Activities

    SciTech Connect (OSTI)

    Carla Miller; Mary Adamic; Stacey Barker; Barry Siskind; Joe Brady; Warren Stern; Heidi Smartt; Mike McDaniel; Mike Stern; Rollin Lakis

    2014-07-01

    Traditionally, IAEA inspectors have focused on the detection of nuclear indicators as part of infield inspection activities. The ability to rapidly detect and identify chemical as well as nuclear signatures can increase the ability of IAEA inspectors to detect undeclared activities at a site. Identification of chemical indicators have been limited to use in the analysis of environmental samples. Although IAEA analytical laboratories are highly effective, environmental sample processing does not allow for immediate or real-time results to an IAEA inspector at a facility. During a complementary access inspection, under the Additional Protocol, the use of fieldable technologies that can quickly provide accurate information on chemicals that may be indicative of undeclared activities can increase the ability of IAEA to effectively and efficiently complete their mission. The Complementary Access Working Group (CAWG) is a multi-laboratory team with members from Brookhaven National Laboratory, Idaho National Laboratory, Los Alamos National Laboratory, and Sandia National Laboratory. The team identified chemicals at each stage of the nuclear fuel cycle that may provide IAEA inspectors with indications that proliferation activities may be occurring. The group eliminated all indicators related to equipment, technology and training, developing a list of by-products/effluents, non-nuclear materials, nuclear materials, and other observables. These proliferation indicators were prioritized based on detectability from a conduct of operations (CONOPS) perspective of a CA inspection (for example, whether an inspector actually can access the S&O or whether it is in process with no physical access), and the IAEA’s interest in the detection technology in conjunction with radiation detectors. The list was consolidated to general categories (nuclear materials from a chemical detection technique, inorganic chemicals, organic chemicals, halogens, and miscellaneous materials). The team

  3. Activation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Emergency Response Services Activated At the Waste Isolation Pilot Plant CARLSBAD, N.M., 252014, 11:43 a.m. (MDT) - Emergency response services have been activated at the Waste...

  4. A CAD system for nodule detection in low-dose lung CTs based on region growing and a new active contour model

    SciTech Connect (OSTI)

    Bellotti, R.; De Carlo, F.; Gargano, G.; Tangaro, S.; Cascio, D.; Catanzariti, E.; Cerello, P.; Cheran, S. C.; Delogu, P.; De Mitri, I.; Fulcheri, C.; Grosso, D.; Retico, A.; Squarcia, S.; Tommasi, E.; Golosio, Bruno

    2007-12-15

    A computer-aided detection (CAD) system for the selection of lung nodules in computer tomography (CT) images is presented. The system is based on region growing (RG) algorithms and a new active contour model (ACM), implementing a local convex hull, able to draw the correct contour of the lung parenchyma and to include the pleural nodules. The CAD consists of three steps: (1) the lung parenchymal volume is segmented by means of a RG algorithm; the pleural nodules are included through the new ACM technique; (2) a RG algorithm is iteratively applied to the previously segmented volume in order to detect the candidate nodules; (3) a double-threshold cut and a neural network are applied to reduce the false positives (FPs). After having set the parameters on a clinical CT, the system works on whole scans, without the need for any manual selection. The CT database was recorded at the Pisa center of the ITALUNG-CT trial, the first Italian randomized controlled trial for the screening of the lung cancer. The detection rate of the system is 88.5% with 6.6 FPs/CT on 15 CT scans (about 4700 sectional images) with 26 nodules: 15 internal and 11 pleural. A reduction to 2.47 FPs/CT is achieved at 80% efficiency.

  5. Radon detection

    DOE Patents [OSTI]

    MacArthur, D.W.; Allander, K.S.; Bounds, J.A.

    1994-01-25

    A detector for atmospheric radon using a long range alpha detector as its sensing element is described. An electrostatic filter removes ions from ambient air, while allowing radon atoms to pass into a decay cavity. Here, radon atoms are allowed to decay, creating air ions. These air ions are drawn by a fan through a second electrostatic filter which can be activated or deactivated, and into the long range alpha detector. With the second electrostatic filter activated, no air ions are allowed to pass, and the signal output from the long range alpha detector consists of only the electronic background. With the second electrostatic filter deactivated, air ions and cosmic rays will be detected. The cosmic ray contribution can be minimized by shielding. 3 figures.

  6. Radon detection

    DOE Patents [OSTI]

    MacArthur, Duncan W.; Allander, Krag S.; Bounds, John A.

    1994-01-01

    A detector for atmospheric radon using a long range alpha detector as its sensing element. An electrostatic filter removes ions from ambient air, while allowing radon atoms to pass into a decay cavity. Here, radon atoms are allowed to decay, creating air ions. These air ions are drawn by a fan through a second electrostatic filter which can be activated or deactivated, and into the long range alpha detector. With the second electrostatic filter activated, no air ions are allowed to pass, and the signal output from the long range alpha detector consists of only the electronic background. With the second electrostatic filter deactivated, air ions and cosmic rays will be detected. The cosmic ray contribution can be minimized by shielding.

  7. Activation detector

    DOE Patents [OSTI]

    Bell, Zane William [Oak Ridge, TN; Boatner, Lynn Allen [Oak Ridge, TN

    2009-12-08

    A method of detecting an activator, the method including impinging with an activator a receptor material lacking a photoluminescent material and generating a by-product of a radioactive decay due to the activator impinging the reeptor material. The method further including, generating light from the by-product via the Cherenkov effect and identifying a characteristic of the activator based on the light.

  8. Detection Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chemistry for Measurement and Detection Science Chemistry for Measurement and Detection Science Project Description Chemistry used in measurement and detection science plays a crucial role in the Laboratory's Science of Signatures scientific thrust. Measurement and detection science areas that require chemistry include nuclear and radiological, materials, biological, energy, climate, and space. Los Alamos scientists integrate chemical-science capabilities to ensure that the Laboratory can

  9. Quantitative Assessment of Detection Frequency for the INL Ambient Air Monitoring Network

    SciTech Connect (OSTI)

    A. Jeffrey Sondrup; Arthur S. Rood

    2014-11-01

    A quantitative assessment of the Idaho National Laboratory (INL) air monitoring network was performed using frequency of detection as the performance metric. The INL air monitoring network consists of 37 low-volume air samplers in 31 different locations. Twenty of the samplers are located on INL (onsite) and 17 are located off INL (offsite). Detection frequencies were calculated using both BEA and ESER laboratory minimum detectable activity (MDA) levels. The CALPUFF Lagrangian puff dispersion model, coupled with 1 year of meteorological data, was used to calculate time-integrated concentrations at sampler locations for a 1-hour release of unit activity (1 Ci) for every hour of the year. The unit-activity time-integrated concentration (TICu) values were calculated at all samplers for releases from eight INL facilities. The TICu values were then scaled and integrated for a given release quantity and release duration. All facilities modeled a ground-level release emanating either from the center of the facility or at a point where significant emissions are possible. In addition to ground-level releases, three existing stacks at the Advanced Test Reactor Complex, Idaho Nuclear Technology and Engineering Center, and Material and Fuels Complex were also modeled. Meteorological data from the 35 stations comprising the INL Mesonet network, data from the Idaho Falls Regional airport, upper air data from the Boise airport, and three-dimensional gridded data from the weather research forecasting model were used for modeling. Three representative radionuclides identified as key radionuclides in INL’s annual National Emission Standards for Hazardous Air Pollutants evaluations were considered for the frequency of detection analysis: Cs-137 (beta-gamma emitter), Pu-239 (alpha emitter), and Sr-90 (beta emitter). Source-specific release quantities were calculated for each radionuclide, such that the maximum inhalation dose at any publicly accessible sampler or the National

  10. Proliferation Detection | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    Research and Development Proliferation Detection The Office of Proliferation Detection (PD) develops capabilities to detect special nuclear materials and weapons production and movement, as well as for transparent nuclear reductions and monitoring. The PD efforts are aligned along three functional areas: Nuclear Weaponization and Material Production Detection: Supports the development of technology to target the detection and characterization of foreign weapons program activities, including

  11. detonation detection

    National Nuclear Security Administration (NNSA)

    7%2A en US Air Force Launches Satellite Carrying NNSA-provided Nuclear Detonation Detection Sensors http:nnsa.energy.govmediaroompressreleasesafsatellite

  12. detonation detection

    National Nuclear Security Administration (NNSA)

    Satellite Carrying NNSA-provided Nuclear Detonation Detection Sensors http:www.nnsa.energy.govmediaroompressreleasesafsatellite

  13. Lichens detect past fallout

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lichens detect past fallout Lichens detect past fallout The team conducted this investigation to define the background concentrations of actinide isotopes present in the environment. November 8, 2015 Usnea lichens are common in New Mexico. Usnea lichens are common in New Mexico. Communications Office (505) 667-7000 Studies of this type could be used in environmental monitoring programs associated with modern nuclear activities Los Alamos researchers and a collaborator at the University of

  14. Composition for detecting uranyl

    DOE Patents [OSTI]

    Baylor, Lewis C.; Stephens, Susan M.

    1995-01-01

    A composition for detecting the presence and concentration of a substance such as uranyl, comprising an organohalide covalently bonded to an indicator for said substance. The composition has at least one active OH site for forming a complex with the substance to be detected. The composition is made by reacting equimolar amounts of the indicator and the organohalide in a polar organic solvent. The absorbance spectrum of the composition-uranyl complex is shifted with respect to the absorbance spectrum of the indicator-uranyl complex, to provide better spectral resolution for detecting uranyl.

  15. Solar system fault detection

    DOE Patents [OSTI]

    Farrington, Robert B.; Pruett, Jr., James C.

    1986-01-01

    A fault detecting apparatus and method are provided for use with an active solar system. The apparatus provides an indication as to whether one or more predetermined faults have occurred in the solar system. The apparatus includes a plurality of sensors, each sensor being used in determining whether a predetermined condition is present. The outputs of the sensors are combined in a pre-established manner in accordance with the kind of predetermined faults to be detected. Indicators communicate with the outputs generated by combining the sensor outputs to give the user of the solar system and the apparatus an indication as to whether a predetermined fault has occurred. Upon detection and indication of any predetermined fault, the user can take appropriate corrective action so that the overall reliability and efficiency of the active solar system are increased.

  16. Solar system fault detection

    DOE Patents [OSTI]

    Farrington, R.B.; Pruett, J.C. Jr.

    1984-05-14

    A fault detecting apparatus and method are provided for use with an active solar system. The apparatus provides an indication as to whether one or more predetermined faults have occurred in the solar system. The apparatus includes a plurality of sensors, each sensor being used in determining whether a predetermined condition is present. The outputs of the sensors are combined in a pre-established manner in accordance with the kind of predetermined faults to be detected. Indicators communicate with the outputs generated by combining the sensor outputs to give the user of the solar system and the apparatus an indication as to whether a predetermined fault has occurred. Upon detection and indication of any predetermined fault, the user can take appropriate corrective action so that the overall reliability and efficiency of the active solar system are increased.

  17. Nucleic acid detection kits

    DOE Patents [OSTI]

    Hall, Jeff G.; Lyamichev, Victor I.; Mast, Andrea L.; Brow, Mary Ann; Kwiatkowski, Robert W.; Vavra, Stephanie H.

    2005-03-29

    The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. The present invention further relates to methods and devices for the separation of nucleic acid molecules based on charge. The present invention also provides methods for the detection of non-target cleavage products via the formation of a complete and activated protein binding region. The invention further provides sensitive and specific methods for the detection of nucleic acid from various viruses in a sample.

  18. Spectroscopic Detection of Pathogens

    SciTech Connect (OSTI)

    ALAM,M. KATHLEEN; TIMLIN,JERILYN A.; MARTIN,LAURA E.; HJELLE,DRIAN; LYONS,RICK; GARRISON,KRISTIN

    2000-11-01

    The goal of this LDRD Research project was to provide a preliminary examination of the use of infrared spectroscopy as a tool to detect the changes in cell cultures upon activation by an infectious agent. Due to a late arrival of funding, only 5 months were available to transfer and setup equipment at UTTM,develop cell culture lines, test methods of in-situ activation and collect kinetic data from activated cells. Using attenuated total reflectance (ATR) as a sampling method, live cell cultures were examined prior to and after activation. Spectroscopic data were collected from cells immediately after activation in situ and, in many cases for five successive hours. Additional data were collected from cells activated within a test tube (pre-activated), in both transmission mode as well as in ATR mode. Changes in the infrared data were apparent in the transmission data collected from the pre-activated cells as well in some of the pre-activated ATR data. Changes in the in-situ activated spectral data were only occasionally present due to (1) the limited time cells were studied and (2) incomplete activation. Comparison of preliminary data to infrared bands reported in the literature suggests the primary changes seen are due an increase in ribonucleic acid (RNA) production. This work will be continued as part of a 3 year DARPA grant.

  19. Fingerprint detection

    DOE Patents [OSTI]

    Saunders, George C. (Rt. 1, Box 428B, Espanola, NM 87532)

    1992-01-01

    A method for detection and visualization of latent fingerprints is provided and includes contacting a substrate containing a latent print thereon with a colloidal metal composition for time sufficient to allow reaction of said colloidal metal composition with said latent print, and preserving or recording the observable print. Further, the method for detection and visualization of latent fingerprints can include contacting the metal composition-latent print reaction product with a secondary metal-containing solution for time sufficient to allow precipitation of said secondary metal thereby enhancing the visibility of the latent print, and preserving or recording the observable print.

  20. Bro Intrusion Detection System

    Energy Science and Technology Software Center (OSTI)

    2006-01-25

    Bro is a Unix-based Network Intrusion Detection System (IDS). Bro monitors network traffic and detects intrusion attempts based on the traffic characteristics and content. Bro detects intrusions by comparing network traffic against rules describing events that are deemed troublesome. These rules might describe activities (e.g., certain hosts connecting to certain services), what activities are worth alerting (e.g., attempts to a given number of different hosts constitutes a "scan"), or signatures describing known attacks or accessmore » to known vulnerabilities. If Bro detects something of interest, it can be instructed to either issue a log entry or initiate the execution of an operating system command. Bro targets high-speed (Gbps), high-volume intrusion detection. By judiciously leveraging packet filtering techniques, Bro is able to achieve the performance necessary to do so while running on commercially available PC hardware, and thus can serve as a cost effective means of monitoring a site’s Internet connection.« less

  1. Detection Apparatus

    DOE Patents [OSTI]

    Anderson, H.L.

    1950-12-05

    This invention concerns a sensitive apparatus for detecting and counting neutrons, particularly neutrons liberated in an alpha, neutron reaction. The apparatus includes an improved ionization chamber structure together with an improved combination alpha-particle source and holder for the material under test.

  2. Detection device

    DOE Patents [OSTI]

    Smith, J.E.

    1981-02-27

    The present invention is directed to a detection device comprising: (1) an entrance chamber; (2) a central chamber; and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

  3. Detection device

    DOE Patents [OSTI]

    Smith, Jay E.

    1984-01-01

    The present invention is directed to a detection device comprising: (1) an entrance chamber, (2) a central chamber, and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

  4. Detection device for hazardous materials

    DOE Patents [OSTI]

    Partin, Judy K.; Grey, Alan E.

    1994-01-01

    A detection device that is activated by the interaction of a hazardous chcal with a coating interactive with said chemical on an optical fiber thereby reducing the amount of light passing through the fiber to a light detector. A combination of optical filters separates the light into a signal beam and a reference beam which after detection, appropriate amplification, and comparison with preset internal signals, activates an alarm means if a predetermined level of contaminant is observed.

  5. Detection device for hazardous materials

    DOE Patents [OSTI]

    Partin, Judy K.; Grey, Alan E.

    1994-04-05

    A detection device that is activated by the interaction of a hazardous chcal with a coating interactive with said chemical on an optical fiber thereby reducing the amount of light passing through the fiber to a light detector. A combination of optical filters separates the light into a signal beam and a reference beam which after detection, appropriate amplification, and comparison with preset internal signals, activates an alarm means if a predetermined level of contaminant is observed.

  6. Spectroscopic detection

    DOE Patents [OSTI]

    Woskov, Paul P.; Hadidi, Kamal

    2003-01-01

    In embodiments, spectroscopic monitor monitors modulated light signals to detect low levels of contaminants and other compounds in the presence of background interference. The monitor uses a spectrometer that includes a transmissive modulator capable of causing different frequency ranges to move onto and off of the detector. The different ranges can include those with the desired signal and those selected to subtract background contributions from those with the desired signal. Embodiments of the system are particularly useful for monitoring metal concentrations in combustion effluent.

  7. MDA0106-Revised for SFAS 133.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    evaluates the performance of the business lines based on Net Operating Margin (NOM) and does not track the separate balance sheets or net revenues on a business line...

  8. Smoke detection

    DOE Patents [OSTI]

    Warmack, Robert J Bruce; Wolf, Dennis A.; Frank, Steven Shane

    2015-11-05

    Various apparatus and methods for smoke detection are disclosed. In one embodiment, a method of training a classifier for a smoke detector comprises inputting sensor data from a plurality of tests into a processor. The sensor data is processed to generate derived signal data corresponding to the test data for respective tests. The derived signal data is assigned into categories comprising at least one fire group and at least one non-fire group. Linear discriminant analysis (LDA) training is performed by the processor. The derived signal data and the assigned categories for the derived signal data are inputs to the LDA training. The output of the LDA training is stored in a computer readable medium, such as in a smoke detector that uses LDA to determine, based on the training, whether present conditions indicate the existence of a fire.

  9. Smoke detection

    SciTech Connect (OSTI)

    Warmack, Robert J. Bruce; Wolf, Dennis A.; Frank, Steven Shane

    2015-10-27

    Various apparatus and methods for smoke detection are disclosed. In one embodiment, a method of training a classifier for a smoke detector comprises inputting sensor data from a plurality of tests into a processor. The sensor data is processed to generate derived signal data corresponding to the test data for respective tests. The derived signal data is assigned into categories comprising at least one fire group and at least one non-fire group. Linear discriminant analysis (LDA) training is performed by the processor. The derived signal data and the assigned categories for the derived signal data are inputs to the LDA training. The output of the LDA training is stored in a computer readable medium, such as in a smoke detector that uses LDA to determine, based on the training, whether present conditions indicate the existence of a fire.

  10. Nucleic acid detection assays

    DOE Patents [OSTI]

    Prudent, James R.; Hall, Jeff G.; Lyamichev, Victor I.; Brow, Mary Ann; Dahlberg, James E.

    2005-04-05

    The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

  11. Nucleic acid detection compositions

    DOE Patents [OSTI]

    Prudent, James R.; Hall, Jeff G.; Lyamichev, Victor I.; Brow, Mary Ann; Dahlberg, James L.

    2008-08-05

    The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

  12. Domestic Nuclear Detection Office's Approach to Detect

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Domestic Nuclear Detection Office's Approach to Detect Concealed Threats Joel Rynes, PhD Department of Homeland Security (DHS) Domestic Nuclear Detection Office (DNDO) August 5, 2015 4:00 p.m. The Transformational and Applied Research (TAR) Directorate within the Domestic Nuclear Detection Office (DNDO) of the Department of Homeland Security (DHS) has the mission to develop break-through technologies that will have a dramatic impact on capabilities to detect nuclear and radiological threats

  13. Fuel washout detection system

    DOE Patents [OSTI]

    Colburn, Richard P.

    1985-01-01

    A system for detecting grossly failed reactor fuel by detection of particulate matter as accumulated on a filter.

  14. How to Detect Radiation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    How to Detect Radiation How to Survey Measurement Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration Detection How to Detect Radiation Radiation cannot be detected by human senses. A variety of instruments are available for detecting and measuring radiation. Examples of radiation survey meters: photos of survey meters alphacounter1.JPG (28857 bytes) This probe is used for the detection of alpha radiation. The most common type of

  15. Portable modular detection system

    DOE Patents [OSTI]

    Brennan, James S. (Rodeo, CA); Singh, Anup (Danville, CA); Throckmorton, Daniel J. (Tracy, CA); Stamps, James F. (Livermore, CA)

    2009-10-13

    Disclosed herein are portable and modular detection devices and systems for detecting electromagnetic radiation, such as fluorescence, from an analyte which comprises at least one optical element removably attached to at least one alignment rail. Also disclosed are modular detection devices and systems having an integrated lock-in amplifier and spatial filter and assay methods using the portable and modular detection devices.

  16. Detection of pump degradation

    SciTech Connect (OSTI)

    Casada, D.

    1995-04-01

    There are a variety of stressors that can affect the operation of centrifugal pumps. Although these general stressors are active in essentially all centrifugal pumps, the stressor level and the extent of wear and degradation can vary greatly. Parameters that affect the extent of stressor activity are manifold. In order to assure the long-term operational readiness of a pump, it is important to both understand the nature and magnitude of the specific degradation mechanisms and to monitor the performance of the pump. The most commonly applied method of monitoring the condition of not only pumps, but rotating machinery in general, is vibration analysis. Periodic or continuous special vibration analysis is a cornerstone of most pump monitoring programs. In the nuclear industry, non-spectral vibration monitoring of safety-related pumps is performed in accordance with the ASME code. Pump head and flow rate are also monitored, per code requirements. Although vibration analysis has dominated the condition monitoring field for many years, there are other measures that have been historically used to help understand pump condition; advances in historically applied technologies and developing technologies offer improved monitoring capabilities. The capabilities of several technologies (including vibration analysis, dynamic pressure analysis, and motor power analysis) to detect the presence and magnitude of both stressors and resultant degradation are discussed.

  17. Advancing Explosives Detection Capabilities: Vapor Detection

    SciTech Connect (OSTI)

    Atkinson, David

    2012-10-15

    A new, PNNL-developed method provides direct, real-time detection of trace amounts of explosives such as RDX, PETN and C-4. The method selectively ionizes a sample before passing the sample through a mass spectrometer to detect explosive vapors. The method could be used at airports to improve aviation security.

  18. Advancing Explosives Detection Capabilities: Vapor Detection

    ScienceCinema (OSTI)

    Atkinson, David

    2014-07-24

    A new, PNNL-developed method provides direct, real-time detection of trace amounts of explosives such as RDX, PETN and C-4. The method selectively ionizes a sample before passing the sample through a mass spectrometer to detect explosive vapors. The method could be used at airports to improve aviation security.

  19. Arsenic activation neutron detector

    DOE Patents [OSTI]

    Jacobs, Eddy L.

    1981-01-01

    A detector of bursts of neutrons from a deuterium-deuteron reaction includes a quantity of arsenic adjacent a gamma detector such as a scintillator and photomultiplier tube. The arsenic is activated by the 2.5 Mev neutrons to release gamma radiation which is detected to give a quantitative representation of detected neutrons.

  20. Arsenic activation neutron detector

    DOE Patents [OSTI]

    Jacobs, E.L.

    1980-01-28

    A detector of bursts of neutrons from a deuterium-deuteron reaction includes a quantity of arsenic adjacent a gamma detector such as a scintillator and photomultiplier tube. The arsenic is activated by the 2.5-MeV neutrons to release gamma radiation which is detected to give a quantitative representation of detected neutrons.

  1. Revolution in Detection Affairs

    SciTech Connect (OSTI)

    Stern W.

    2013-11-02

    The detection of nuclear or radioactive materials for homeland or national security purposes is inherently difficult. This is one reason detection efforts must be seen as just one part of an overall nuclear defense strategy which includes, inter alia, material security, detection, interdiction, consequence management and recovery. Nevertheless, one could argue that there has been a revolution in detection affairs in the past several decades as the innovative application of new technology has changed the character and conduct of detection operations. This revolution will likely be most effectively reinforced in the coming decades with the networking of detectors and innovative application of anomaly detection algorithms.

  2. Methods, microfluidic devices, and systems for detection of an...

    Office of Scientific and Technical Information (OSTI)

    Methods, microfluidic devices, and systems for detection of an active enzymatic agent Citation Details In-Document Search Title: Methods, microfluidic devices, and systems for...

  3. Interior intrusion detection systems

    SciTech Connect (OSTI)

    Rodriguez, J.R.; Matter, J.C. ); Dry, B. )

    1991-10-01

    The purpose of this NUREG is to present technical information that should be useful to NRC licensees in designing interior intrusion detection systems. Interior intrusion sensors are discussed according to their primary application: boundary-penetration detection, volumetric detection, and point protection. Information necessary for implementation of an effective interior intrusion detection system is presented, including principles of operation, performance characteristics and guidelines for design, procurement, installation, testing, and maintenance. A glossary of sensor data terms is included. 36 figs., 6 tabs.

  4. Methods, microfluidic devices, and systems for detection of an...

    Office of Scientific and Technical Information (OSTI)

    for the detection of an active target agent in a fluid sample. A substrate molecule is used that contains a sequence which may cleave in the presence of an active target agent. ...

  5. Intelligent Leak Detection System

    SciTech Connect (OSTI)

    Mohaghegh, Shahab D.

    2014-10-27

    apability of underground carbon dioxide storage to confine and sustain injected CO2 for a very long time is the main concern for geologic CO2 sequestration. If a leakage from a geological CO2 sequestration site occurs, it is crucial to find the approximate amount and the location of the leak in order to implement proper remediation activity. An overwhelming majority of research and development for storage site monitoring has been concentrated on atmospheric, surface or near surface monitoring of the sequestered CO2. This study aims to monitor the integrity of CO2 storage at the reservoir level. This work proposes developing in-situ CO2 Monitoring and Verification technology based on the implementation of Permanent Down-hole Gauges (PDG) or “Smart Wells” along with Artificial Intelligence and Data Mining (AI&DM). The technology attempts to identify the characteristics of the CO2 leakage by de-convolving the pressure signals collected from Permanent Down-hole Gauges (PDG). Citronelle field, a saline aquifer reservoir, located in the U.S. was considered for this study. A reservoir simulation model for CO2 sequestration in the Citronelle field was developed and history matched. The presence of the PDGs were considered in the reservoir model at the injection well and an observation well. High frequency pressure data from sensors were collected based on different synthetic CO2 leakage scenarios in the model. Due to complexity of the pressure signal behaviors, a Machine Learning-based technology was introduced to build an Intelligent Leakage Detection System (ILDS). The ILDS was able to detect leakage characteristics in a short period of time (less than a day) demonstrating the capability of the system in quantifying leakage characteristics subject to complex rate behaviors. The performance of ILDS was examined under different conditions such as multiple well leakages, cap rock leakage, availability of an additional monitoring well, presence of pressure drift and noise

  6. Intelligent Leak Detection System

    Energy Science and Technology Software Center (OSTI)

    2014-10-27

    apability of underground carbon dioxide storage to confine and sustain injected CO2 for a very long time is the main concern for geologic CO2 sequestration. If a leakage from a geological CO2 sequestration site occurs, it is crucial to find the approximate amount and the location of the leak in order to implement proper remediation activity. An overwhelming majority of research and development for storage site monitoring has been concentrated on atmospheric, surface or nearmore » surface monitoring of the sequestered CO2. This study aims to monitor the integrity of CO2 storage at the reservoir level. This work proposes developing in-situ CO2 Monitoring and Verification technology based on the implementation of Permanent Down-hole Gauges (PDG) or “Smart Wells” along with Artificial Intelligence and Data Mining (AI&DM). The technology attempts to identify the characteristics of the CO2 leakage by de-convolving the pressure signals collected from Permanent Down-hole Gauges (PDG). Citronelle field, a saline aquifer reservoir, located in the U.S. was considered for this study. A reservoir simulation model for CO2 sequestration in the Citronelle field was developed and history matched. The presence of the PDGs were considered in the reservoir model at the injection well and an observation well. High frequency pressure data from sensors were collected based on different synthetic CO2 leakage scenarios in the model. Due to complexity of the pressure signal behaviors, a Machine Learning-based technology was introduced to build an Intelligent Leakage Detection System (ILDS). The ILDS was able to detect leakage characteristics in a short period of time (less than a day) demonstrating the capability of the system in quantifying leakage characteristics subject to complex rate behaviors. The performance of ILDS was examined under different conditions such as multiple well leakages, cap rock leakage, availability of an additional monitoring well, presence of pressure drift

  7. Sulfide chemiluminescence detection

    DOE Patents [OSTI]

    Spurlin, Stanford R. (Ames, IA); Yeung, Edward S. (Ames, IA)

    1985-01-01

    A method of chemiluminescently determining a sulfide which is either hydrogen sulfide or methyl mercaptan by reacting the sulfide with chlorine dioxide at low pressure and under conditions which allow a longer reaction time in emission of a single photon for every two sulfide containing species, and thereafter, chemiluminescently detecting and determining the sulfide. The invention also relates not only to the detection method, but the novel chemical reaction and a specifically designed chemiluminescence detection cell for the reaction.

  8. Sulfide chemiluminescence detection

    DOE Patents [OSTI]

    Spurlin, S.R.; Yeung, E.S.

    1985-11-26

    A method is described for chemiluminescently determining a sulfide which is either hydrogen sulfide or methyl mercaptan by reacting the sulfide with chlorine dioxide at low pressure and under conditions which allow a longer reaction time in emission of a single photon for every two sulfide containing species, and thereafter, chemiluminescently detecting and determining the sulfide. The invention also relates not only to the detection method, but the novel chemical reaction and a specifically designed chemiluminescence detection cell for the reaction. 4 figs.

  9. Neutron detection apparatus

    DOE Patents [OSTI]

    Kopp, Manfred K.; Valentine, Kenneth H.

    1983-01-01

    An atomic fission counting apparatus used for neutron detection is provided with spirally curved electrode plates uniformly spaced apart in a circular array and coated with fissile material.

  10. Fast Neutron Detection Evaluation

    SciTech Connect (OSTI)

    McKigney, Edward A.; Stange, Sy

    2014-03-17

    These slides present a summary of previous work, conclusions, and anticipated schedule for the conclusion of our fast neutron detection evaluation.

  11. Technologies for detection of nuclear materials

    SciTech Connect (OSTI)

    DeVolpi, A.

    1996-03-30

    Detection of smuggled nuclear materials at transit points requires monitoring unknown samples in large closed packages. This review contends that high-confidence nuclear-material detection requires induced fission as the primary mechanism, with passive radiation screening in a complementary role. With the right equipment, even small quantities of nuclear materials are detectable with a high probability at transit points. The equipment could also be linked synergistically with detectors of other contrabond. For screening postal mail and packages, passive monitors are probably more cost-effective. When a suspicious item is detected, a single active probe could then be used. Until active systems become mass produced, this two-stage screening/interrogation role for active/passive equipment is more economic for cargo at border crossings. For widespread monitoring of nuclear smuggling, it will probably be necessary to develop a system for simultaneously detecting most categories of contraband, including explosives and illicit drugs. With control of nuclear materials at known storage sites being the first line of defense, detection capabilities at international borders could establish a viable second line of defense against smuggling.

  12. Array for detecting microbes

    DOE Patents [OSTI]

    Andersen, Gary L.; DeSantis, Todd D.

    2014-07-08

    The present embodiments relate to an array system for detecting and identifying biomolecules and organisms. More specifically, the present embodiments relate to an array system comprising a microarray configured to simultaneously detect a plurality of organisms in a sample at a high confidence level.

  13. Lean blowoff detection sensor

    DOE Patents [OSTI]

    Thornton, Jimmy; Straub, Douglas L.; Chorpening, Benjamin T.; Huckaby, David

    2007-04-03

    Apparatus and method for detecting incipient lean blowoff conditions in a lean premixed combustion nozzle of a gas turbine. A sensor near the flame detects the concentration of hydrocarbon ions and/or electrons produced by combustion and the concentration monitored as a function of time are used to indicate incipient lean blowoff conditions.

  14. Leak detection aid

    DOE Patents [OSTI]

    Steeper, Timothy J.

    1989-01-01

    A leak detection apparatus and method for detecting leaks across an O-ring sealing a flanged surface to a mating surface is an improvement in a flanged surface comprising a shallow groove following O-ring in communication with an entrance and exit port intersecting the shallow groove for injecting and withdrawing, respectively, a leak detection fluid, such as helium. A small quantity of helium injected into the entrance port will flow to the shallow groove, past the O-ring and to the exit port.

  15. Leak detection aid

    DOE Patents [OSTI]

    Steeper, T.J.

    1989-12-26

    A leak detection apparatus and method for detecting leaks across an O-ring sealing a flanged surface to a mating surface is an improvement in a flanged surface comprising a shallow groove following O-ring in communication with an entrance and exit port intersecting the shallow groove for injecting and withdrawing, respectively, a leak detection fluid, such as helium. A small quantity of helium injected into the entrance port will flow to the shallow groove, past the O-ring and to the exit port. 2 figs.

  16. Idaho Explosive Detection System

    ScienceCinema (OSTI)

    Klinger, Jeff

    2013-05-28

    Learn how INL researchers are making the world safer by developing an explosives detection system that can inspect cargo. For more information about INL security research, visit http://www.facebook.com/idahonationallaboratory

  17. Explosive Detection Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-10-26

    To standardize and accelerate implementation of the Department of Energy (DOE) explosive detection program. DOE N 251.40, dated 5/3/01, extends this directive until 12/31/01.

  18. Bolt failure detection

    SciTech Connect (OSTI)

    Sutton, Jr., Harry G.

    1984-01-01

    Bolts of a liquid metal fast breeder reactor, each bolt provided with an internal chamber filled with a specific, unique radioactive tag gas. Detection of the tag gas is indicative of a crack in an identifiable bolt.

  19. Detection of counterfeit currency

    DOE Patents [OSTI]

    Burns, Donald A.

    1998-01-01

    A method of detecting counterfeit currency by contacting the currency to be tested with near infrared beams in the spectrum below 1250 namometers, measuring reflectance of the near infrared beams and comparing the reflectance values with those from genuine currency.

  20. Idaho Explosive Detection System

    SciTech Connect (OSTI)

    Klinger, Jeff

    2011-01-01

    Learn how INL researchers are making the world safer by developing an explosives detection system that can inspect cargo. For more information about INL security research, visit http://www.facebook.com/idahonationallaboratory

  1. Photovoltaic System Fault Detection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Photovoltaic System Fault Detection and Diagnostics using Laterally Primed Adaptive Resonance Theory Neural Network C. Birk Jones, Joshua S. Stein, Sigifredo Gonzalez, and Bruce H. King Sandia National Laboratories, Albuquerque, NM, 87185, U.S.A Abstract-Cost effective integration of solar photovoltaic (PV) systems requires increased reliability. This can be achieved with a robust fault detection and diagnostic (FDD) tool that auto- matically discovers faults. This paper introduces the Laterally

  2. Active-R filter

    DOE Patents [OSTI]

    Soderstrand, Michael A.

    1976-01-01

    An operational amplifier-type active filter in which the only capacitor in the circuit is the compensating capacitance of the operational amplifiers, the various feedback and coupling elements being essentially solely resistive.

  3. Temperature differential detection device

    DOE Patents [OSTI]

    Girling, Peter M.

    1986-01-01

    A temperature differential detection device for detecting the temperature differential between predetermined portions of a container wall is disclosed as comprising a Wheatstone bridge circuit for detecting resistance imbalance with a first circuit branch having a first elongated wire element mounted in thermal contact with a predetermined portion of the container wall, a second circuit branch having a second elongated wire element mounted in thermal contact with a second predetermined portion of a container wall with the wire elements having a predetermined temperature-resistant coefficient, an indicator interconnected between the first and second branches remote from the container wall for detecting and indicating resistance imbalance between the first and second wire elements, and connector leads for electrically connecting the wire elements to the remote indicator in order to maintain the respective resistance value relationship between the first and second wire elements. The indicator is calibrated to indicate the detected resistance imbalance in terms of a temperature differential between the first and second wall portions.

  4. Temperature differential detection device

    DOE Patents [OSTI]

    Girling, P.M.

    1986-04-22

    A temperature differential detection device for detecting the temperature differential between predetermined portions of a container wall is disclosed as comprising a Wheatstone bridge circuit for detecting resistance imbalance with a first circuit branch having a first elongated wire element mounted in thermal contact with a predetermined portion of the container wall, a second circuit branch having a second elongated wire element mounted in thermal contact with a second predetermined portion of a container wall with the wire elements having a predetermined temperature-resistant coefficient, an indicator interconnected between the first and second branches remote from the container wall for detecting and indicating resistance imbalance between the first and second wire elements, and connector leads for electrically connecting the wire elements to the remote indicator in order to maintain the respective resistance value relationship between the first and second wire elements. The indicator is calibrated to indicate the detected resistance imbalance in terms of a temperature differential between the first and second wall portions. 2 figs.

  5. Error detection method

    DOE Patents [OSTI]

    Olson, Eric J.

    2013-06-11

    An apparatus, program product, and method that run an algorithm on a hardware based processor, generate a hardware error as a result of running the algorithm, generate an algorithm output for the algorithm, compare the algorithm output to another output for the algorithm, and detect the hardware error from the comparison. The algorithm is designed to cause the hardware based processor to heat to a degree that increases the likelihood of hardware errors to manifest, and the hardware error is observable in the algorithm output. As such, electronic components may be sufficiently heated and/or sufficiently stressed to create better conditions for generating hardware errors, and the output of the algorithm may be compared at the end of the run to detect a hardware error that occurred anywhere during the run that may otherwise not be detected by traditional methodologies (e.g., due to cooling, insufficient heat and/or stress, etc.).

  6. Void detecting device

    DOE Patents [OSTI]

    Nakamoto, Koichiro; Ohyama, Nobumi; Adachi, Kiyoshi; Kuwahara, Hajime

    1979-01-01

    A detector to be inserted into a flowing conductive fluid, e.g. sodium coolant in a nuclear reactor, comprising at least one exciting coil to receive an a-c signal applied thereto and two detecting coils located in the proximity of the exciting coil. The difference and/or the sum of the output signals of the detecting coils is computed to produce a flow velocity signal and/or a temperature-responsive signal for the fluid. Such flow velocity signal or temperature signal is rectified synchronously by a signal the phase of which is shifted substantially .+-. 90.degree. with respect to the flow velocity signal or temperature signal, thereby enabling the device to detect voids in the flowing fluid without adverse effects from flow velocity variations or flow disturbances occurring in the fluid.

  7. Composition for detecting uranyl

    DOE Patents [OSTI]

    Baylor, L.C.; Stephens, S.M.

    1994-01-01

    The present invention relates to an indicator composition for use in spectrophotometric detection of a substance in a solution, and a method for making the composition. Useful indicators are sensitive to the particular substance being measured, but are unaffected by the fluid and other chemical species that may be present in the fluid. Optical indicators are used to measure the uranium concentration of process solutions in facilities for extracting uranium from ores, production of nuclear fuels, and reprocessing of irradiated fuels. The composition comprises an organohalide covalently bonded to an indicator for the substance, in such a manner that the product is itself an indicator that provides increased spectral resolution for detecting the substance. The indicator is preferably arsenazo III and the organohalide is preferably cyanuric chloride. These form a composition that is ideally suited for detecting uranyl.

  8. Detection of neutrinos

    DOE Patents [OSTI]

    Fischbach, Ephraim; Jenkins, Jere

    2016-05-10

    A flux detection apparatus can include a radioactive sample having a decay rate capable of changing in response to interaction with a first particle or a field, and a detector associated with the radioactive sample. The detector is responsive to a second particle or radiation formed by decay of the radioactive sample. The rate of decay of the radioactive sample can be correlated to flux of the first particle or the field. Detection of the first particle or the field can provide an early warning for an impending solar event.

  9. Radiation detection system

    DOE Patents [OSTI]

    Nelson, Melvin A.; Davies, Terence J.; Morton, III, John R.

    1976-01-01

    A radiation detection system which utilizes the generation of Cerenkov light in and the transmission of that light longitudinally through fiber optic wave guides in order to transmit intelligence relating to the radiation to a remote location. The wave guides are aligned with respect to charged particle radiation so that the Cerenkov light, which is generated at an angle to the radiation, is accepted by the fiber for transmission therethrough. The Cerenkov radiation is detected, recorded, and analyzed at the other end of the fiber.

  10. Relating to ion detection

    DOE Patents [OSTI]

    Orr, Christopher Henry; Luff, Craig Janson; Dockray, Thomas; Macarthur, Duncan Whittemore

    2001-01-01

    The apparatus and method provide a technique for improving detection of alpha and/or beta emitting sources on items or in locations using indirect means. The emission forms generate ions in a medium surrounding the item or location and the medium is then moved to a detecting location where the ions are discharged to give a measure of the emission levels. To increase the level of ions generated and render the system particularly applicable for narrow pipes and other forms of conduits, the medium pressure is increased above atmospheric pressure. STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

  11. Portable pathogen detection system

    DOE Patents [OSTI]

    Colston, Billy W.; Everett, Matthew; Milanovich, Fred P.; Brown, Steve B.; Vendateswaran, Kodumudi; Simon, Jonathan N.

    2005-06-14

    A portable pathogen detection system that accomplishes on-site multiplex detection of targets in biological samples. The system includes: microbead specific reagents, incubation/mixing chambers, a disposable microbead capture substrate, and an optical measurement and decoding arrangement. The basis of this system is a highly flexible Liquid Array that utilizes optically encoded microbeads as the templates for biological assays. Target biological samples are optically labeled and captured on the microbeads, which are in turn captured on an ordered array or disordered array disposable capture substrate and then optically read.

  12. Detection of solar events

    DOE Patents [OSTI]

    Fischbach, Ephraim; Jenkins, Jere

    2013-08-27

    A flux detection apparatus can include a radioactive sample having a decay rate capable of changing in response to interaction with a first particle or a field, and a detector associated with the radioactive sample. The detector is responsive to a second particle or radiation formed by decay of the radioactive sample. The rate of decay of the radioactive sample can be correlated to flux of the first particle or the field. Detection of the first particle or the field can provide an early warning for an impending solar event.

  13. Detection of neutrinos

    DOE Patents [OSTI]

    Fischbach, Ephraim; Jenkins, Jere

    2014-02-04

    A flux detection apparatus can include a radioactive sample having a decay rate capable of changing in response to interaction with a first particle or a field, and a detector associated with the radioactive sample. The detector is responsive to a second particle or radiation formed by decay of the radioactive sample. The rate of decay of the radioactive sample can be correlated to flux of the first particle or the field. Detection of the first particle or the field can provide an early warning for an impending solar event.

  14. Detecting bioterrorism: Is chemistry enough?

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Detecting bioterrorism: Is chemistry enough? Detecting bioterrorism: Is chemistry enough? In an online webinar, Kristin Omberg will offer discussion on the possibilities and ...

  15. Radiation detection system

    DOE Patents [OSTI]

    Franks, Larry A.; Lutz, Stephen S.; Lyons, Peter B.

    1981-01-01

    A radiation detection system including a radiation-to-light converter and fiber optic wave guides to transmit the light to a remote location for processing. The system utilizes fluors particularly developed for use with optical fibers emitting at wavelengths greater than about 500 nm and having decay times less than about 10 ns.

  16. DETECTION OR WARNING SYSTEM

    DOE Patents [OSTI]

    Tillman, J.E.

    1953-10-20

    This patent application describes a sensitive detection or protective system capable of giving an alarm or warning upon the entrance or intrusion of any body into a defined area or zone protected by a radiation field of suitable direction or extent.

  17. Detection of counterfeit currency

    DOE Patents [OSTI]

    Burns, D.A.

    1998-05-26

    A method is disclosed of detecting counterfeit currency by contacting the currency to be tested with near infrared beams in the spectrum below 1,250 nanometers, measuring reflectance of the near infrared beams and comparing the reflectance values with those from genuine currency. 18 figs.

  18. Nitrogen dioxide detection

    DOE Patents [OSTI]

    Sinha, Dipen N.; Agnew, Stephen F.; Christensen, William H.

    1993-01-01

    Method and apparatus for detecting the presence of gaseous nitrogen dioxide and determining the amount of gas which is present. Though polystyrene is normally an insulator, it becomes electrically conductive in the presence of nitrogen dioxide. Conductance or resistance of a polystyrene sensing element is related to the concentration of nitrogen dioxide at the sensing element.

  19. Liquid detection circuit

    DOE Patents [OSTI]

    Regan, Thomas O.

    1987-01-01

    Herein is a circuit which is capable of detecting the presence of liquids, especially cryogenic liquids, and whose sensor will not overheat in a vacuum. The circuit parameters, however, can be adjusted to work with any liquid over a wide range of temperatures.

  20. Microsoft Word - 3rd Qtr - MDA.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 million from last year. Operating Revenues Revenues from electricity and transmission sales for the nine months ended June 30, 2005, were nearly unchanged when compared...

  1. MDA- Energy Efficiency Revolving Loan Program | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    school districts Hospitals (public, private, and non-profit) Institutions of higher learning Sole proprietors and partnerships National or regional headquarters operations...

  2. Current Trends in Gamma Ray Detection for Radiological Emergency Response

    SciTech Connect (OSTI)

    Mukhopadhyay, S., Guss, P., Maurer, R.

    2011-08-18

    Passive and active detection of gamma rays from shielded radioactive materials, including special nuclear materials, is an important task for any radiological emergency response organization. This article reports on the current trends and status of gamma radiation detection objectives and measurement techniques as applied to nonproliferation and radiological emergencies.

  3. Solar neutrino detection

    SciTech Connect (OSTI)

    Miramonti, Lino

    2009-04-30

    More than 40 years ago, neutrinos where conceived as a way to test the validity of the solar models which tell us that stars are powered by nuclear fusion reactions. The first measurement of the neutrino flux, in 1968 in the Homestake mine in South Dakota, detected only one third of the expected value, originating what has been known as the Solar Neutrino Problem. Different experiments were built in order to understand the origin of this discrepancy. Now we know that neutrinos undergo oscillation phenomenon changing their nature traveling from the core of the Sun to our detectors. In the work the 40 year long saga of the neutrino detection is presented; from the first proposals to test the solar models to last real time measurements of the low energy part of the neutrino spectrum.

  4. Cell Phone Detection Techniques

    SciTech Connect (OSTI)

    Pratt, Richard M.; Bunch, Kyle J.; Puzycki, David J.; Slaugh, Ryan W.; Good, Morris S.; McMakin, Douglas L.

    2007-10-01

    A team composed of Rick Pratt, Dave Puczyki, Kyle Bunch, Ryan Slaugh, Morris Good, and Doug McMakin teamed together to attempt to exploit cellular telephone features and detect if a person was carrying a cellular telephone into a Limited Area. The cell phone’s electromagnetic properties were measured, analyzed, and tested in over 10 different ways to determine if an exploitable signature exists. The method that appears to have the most potential for success without adding an external tag is to measure the RF spectrum, not in the cell phone band, but between 240 and 400MHz. Figures 1- 7 show the detected signal levels from cell phones from three different manufacturers.

  5. Chlorofluorocarbon leak detection technology

    SciTech Connect (OSTI)

    Munday, E.B.

    1990-12-01

    There are about 590 large coolant systems located at the Portsmouth Gaseous Diffusion Plant (PORTS) and the Paducah Gaseous Diffusion Plant (PGDP) leaking nearly 800,000 lb of R-114 refrigerant annually (1989 estimate). A program is now under way to reduce the leakage to 325,000 lb/year -- an average loss of 551 lb/year (0.063 lb/h) per coolant system, some of which are as large as 800 ft. This report investigates leak detection technologies that can be used to locate leaks in the coolant systems. Included are descriptions, minimum leak detection rate levels, advantages, disadvantages, and vendor information on the following technologies: bubbling solutions; colorimetric leak testing; dyes; halogen leak detectors (coronea discharge detectors; halide torch detectors, and heated anode detectors); laser imaging; mass spectroscopy; organic vapor analyzers; odorants; pressure decay methods; solid-state electrolytic-cell gas sensors; thermal conductivity leak detectors; and ultrasonic leak detectors.

  6. Interim explosives detection alternatives

    SciTech Connect (OSTI)

    Syler, R.P. )

    1991-01-01

    There is a general concern with insiders smuggling bomb quantities of explosives into sensitive facilities such as nuclear facilities. At this time, there is no single explosives detection device that is suitable for monitoring personnel and their packages for explosives in an operational facility environment. However, there are techniques combining available commercial technologies with procedures and threat analysis that can significantly increase the insiders risk and reduce the population of adversaries. This paper describes the available applicable explosives detection technologies and discusses the techniques that could be implemented on an interim basis. It is important that these techniques be considered, so that some interim level of security against the explosives threat can be established until more sophisticated equipment that is under development becomes available.

  7. Protein detection system

    DOE Patents [OSTI]

    Fruetel, Julie A.; Fiechtner, Gregory J.; Kliner, Dahv A. V.; McIlroy, Andrew

    2009-05-05

    The present embodiment describes a miniature, microfluidic, absorption-based sensor to detect proteins at sensitivities comparable to LIF but without the need for tagging. This instrument utilizes fiber-based evanescent-field cavity-ringdown spectroscopy, in combination with faceted prism microchannels. The combination of these techniques will increase the effective absorption path length by a factor of 10.sup.3 to 10.sup.4 (to .about.1-m), thereby providing unprecedented sensitivity using direct absorption. The coupling of high-sensitivity absorption with high-performance microfluidic separation will enable real-time sensing of biological agents in aqueous samples (including aerosol collector fluids) and will provide a general method with spectral fingerprint capability for detecting specific bio-agents.

  8. Fraud Detection in Healthcare

    SciTech Connect (OSTI)

    Chandola, Varun; Schryver, Jack C; Sukumar, Sreenivas R

    2015-01-01

    We discuss the problem of fraud detection in healthcare in this chapter. Given the recent scrutiny of the ineciencies in the US healthcare system, identifying fraud has been on the forefront of the eorts towards reducing the healthcare costs. In this chapter we will focus on understanding the issue of healthcare fraud in detail, and review methods that have been proposed in the literature to combat this issue using data driven approach.

  9. Aspects of leak detection

    SciTech Connect (OSTI)

    Chivers, T.C.

    1997-04-01

    A requirement of a Leak before Break safety case is that the leakage from the through wall crack be detected prior to any growth leading to unacceptable failure. This paper sets out to review some recent developments in this field. It does not set out to be a comprehensive guide to all of the methods available. The discussion concentrates on acoustic emission and how the techniques can be qualified and deployed on operational plant.

  10. Method for detecting biomolecules

    DOE Patents [OSTI]

    Huo, Qisheng; Liu, Jun

    2008-08-12

    A method for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least one surface of the conducting electrode. The film is functionalized with probe molecules that chemically interact with the target biomolecules at the film surface, blocking indicator molecules present in solution from diffusing from the solution to the electrode, thereby changing the electrochemical response of the electrode

  11. Biomolecular detection device

    DOE Patents [OSTI]

    Huo, Qisheng; Liu, Jun

    2008-10-21

    A device for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least one surface of the conducting electrode. The film is functionalized with probe molecules that chemically interact with the target biomolecules at the film surface, blocking indicator molecules present in solution from diffusing from the solution to the electrode, thereby changing the electrochemical response of the electrode.

  12. Nucleic Acid Detection Methods

    DOE Patents [OSTI]

    Smith, Cassandra L.; Yaar, Ron; Szafranski, Przemyslaw; Cantor, Charles R.

    1998-05-19

    The invention relates to methods for rapidly determining the sequence and/or length a target sequence. The target sequence may be a series of known or unknown repeat sequences which are hybridized to an array of probes. The hybridized array is digested with a single-strand nuclease and free 3'-hydroxyl groups extended with a nucleic acid polymerase. Nuclease cleaved heteroduplexes can be easily distinguish from nuclease uncleaved heteroduplexes by differential labeling. Probes and target can be differentially labeled with detectable labels. Matched target can be detected by cleaving resulting loops from the hybridized target and creating free 3-hydroxyl groups. These groups are recognized and extended by polymerases added into the reaction system which also adds or releases one label into solution. Analysis of the resulting products using either solid phase or solution. These methods can be used to detect characteristic nucleic acid sequences, to determine target sequence and to screen for genetic defects and disorders. Assays can be conducted on solid surfaces allowing for multiple reactions to be conducted in parallel and, if desired, automated.

  13. Nucleic acid detection methods

    DOE Patents [OSTI]

    Smith, C.L.; Yaar, R.; Szafranski, P.; Cantor, C.R.

    1998-05-19

    The invention relates to methods for rapidly determining the sequence and/or length a target sequence. The target sequence may be a series of known or unknown repeat sequences which are hybridized to an array of probes. The hybridized array is digested with a single-strand nuclease and free 3{prime}-hydroxyl groups extended with a nucleic acid polymerase. Nuclease cleaved heteroduplexes can be easily distinguish from nuclease uncleaved heteroduplexes by differential labeling. Probes and target can be differentially labeled with detectable labels. Matched target can be detected by cleaving resulting loops from the hybridized target and creating free 3-hydroxyl groups. These groups are recognized and extended by polymerases added into the reaction system which also adds or releases one label into solution. Analysis of the resulting products using either solid phase or solution. These methods can be used to detect characteristic nucleic acid sequences, to determine target sequence and to screen for genetic defects and disorders. Assays can be conducted on solid surfaces allowing for multiple reactions to be conducted in parallel and, if desired, automated. 18 figs.

  14. Host-Based Data Exfiltration Detection via System Call Sequences

    SciTech Connect (OSTI)

    Beaver, Justin M; Jewell, Brian C

    2011-01-01

    The host-based detection of malicious data exfiltration activities is currently a sparse area of research and mostly limited to methods that analyze network traffic or signature based detection methods that target specific processes. In this paper we explore an alternative method to host-based detection that exploits sequences of system calls and new collection methods that allow us to catch these activities in real time. We show that system calls sequences can be found to reach a steady state across processes and users, and explore the viability of new methods as heuristics for profiling user behaviors.

  15. Sequential Detection of Fission Processes for Harbor Defense

    SciTech Connect (OSTI)

    Candy, J V; Walston, S E; Chambers, D H

    2015-02-12

    With the large increase in terrorist activities throughout the world, the timely and accurate detection of special nuclear material (SNM) has become an extremely high priority for many countries concerned with national security. The detection of radionuclide contraband based on their Îł-ray emissions has been attacked vigorously with some interesting and feasible results; however, the fission process of SNM has not received as much attention due to its inherent complexity and required predictive nature. In this paper, on-line, sequential Bayesian detection and estimation (parameter) techniques to rapidly and reliably detect unknown fissioning sources with high statistical confidence are developed.

  16. radiation detection | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    radiation detection NNSA Deputy Administrator Creedon Travels to China In March, National Nuclear Security Administration (NNSA) Principal Deputy Administrator Madelyn Creedon traveled to China to participate in activities related to NNSA's cooperative engagement with various Chinese ministries on nuclear security. Creedon was accompanied by Principal Assistant... NNSA keeps the promises borne out of the Nuclear Security Summit On Thursday and Friday President Obama will host his fourth and

  17. Revolution in nuclear detection affairs

    SciTech Connect (OSTI)

    Stern, Warren M.

    2014-05-09

    The detection of nuclear or radioactive materials for homeland or national security purposes is inherently difficult. This is one reason detection efforts must be seen as just one part of an overall nuclear defense strategy which includes, inter alia, material security, detection, interdiction, consequence management and recovery. Nevertheless, one could argue that there has been a revolution in detection affairs in the past several decades as the innovative application of new technology has changed the character and conduct of detection operations. This revolution will likely be most effectively reinforced in the coming decades with the networking of detectors and innovative application of anomaly detection algorithms.

  18. Electrical leakage detection circuit

    DOE Patents [OSTI]

    Wild, Arthur

    2006-09-05

    A method is provided for detecting electrical leakage between a power supply and a frame of a vehicle or machine. The disclosed method includes coupling a first capacitor between a frame and a first terminal of a power supply for a predetermined period of time. The current flowing between the frame and the first capacitor is limited to a predetermined current limit. It is determined whether the voltage across the first capacitor exceeds a threshold voltage. A first output signal is provided when the voltage across the capacitor exceeds the threshold voltage.

  19. Opaque cloud detection

    DOE Patents [OSTI]

    Roskovensky, John K.

    2009-01-20

    A method of detecting clouds in a digital image comprising, for an area of the digital image, determining a reflectance value in at least three discrete electromagnetic spectrum bands, computing a first ratio of one reflectance value minus another reflectance value and the same two values added together, computing a second ratio of one reflectance value and another reflectance value, choosing one of the reflectance values, and concluding that an opaque cloud exists in the area if the results of each of the two computing steps and the choosing step fall within three corresponding predetermined ranges.

  20. Flaw detection and evaluation

    DOE Patents [OSTI]

    Wilks, Robert S.; Sturges, Jr., Robert H.

    1983-01-01

    The invention provides a method of and apparatus for optically inspecting nuclear fuel pellets for surface flaws. The inspection system includes a prism and lens arrangement for scanning the surface of each pellet as the same is rotated. The resulting scan produces data indicative of the extent and shape of each flaw which is employed to generate a flaw quality index for each detected flaw. The flaw quality indexes from all flaws are summed and compared with an acceptable surface quality index. The result of the comparison is utilized to control the acceptance or rejection of the pellet.

  1. HIGH ENERGY POLARIZATION OF BLAZARS: DETECTION PROSPECTS

    SciTech Connect (OSTI)

    Chakraborty, N.; Pavlidou, V.; Fields, B. D.

    2015-01-01

    Emission from blazar jets in the ultraviolet, optical, and infrared is polarized. If these low-energy photons were inverse-Compton scattered, the upscattered high-energy photons retain a fraction of the polarization. Current and future X-ray and gamma-ray polarimeters such as INTEGRAL-SPI, PoGOLITE, X-Calibur, Gamma-Ray Burst Polarimeter, GEMS-like missions, ASTRO-H, and POLARIX have the potential to discover polarized X-rays and gamma-rays from blazar jets for the first time. Detection of such polarization will open a qualitatively new window into high-energy blazar emission; actual measurements of polarization degree and angle will quantitatively test theories of jet emission mechanisms. We examine the detection prospects of blazars by these polarimetry missions using examples of 3C 279, PKS 1510-089, and 3C 454.3, bright sources with relatively high degrees of low-energy polarization. We conclude that while balloon polarimeters will be challenged to detect blazars within reasonable observational times (with X-Calibur offering the most promising prospects), space-based missions should detect the brightest blazars for polarization fractions down to a few percent. Typical flaring activity of blazars could boost the overall number of polarimetric detections by nearly a factor of five to six purely accounting for flux increase of the brightest of the comprehensive, all-sky, Fermi-LAT blazar distribution. The instantaneous increase in the number of detections is approximately a factor of two, assuming a duty cycle of 20% for every source. The detectability of particular blazars may be reduced if variations in the flux and polarization fraction are anticorrelated. Simultaneous use of variability and polarization trends could guide the selection of blazars for high-energy polarimetric observations.

  2. Network Activity

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Statistics Network Activity Network Activity PDSF Network Uplinks to NERSC (dual 10 Gbps) NERSC Uplink to ESnet Last edited: 2011-03-31 22:20:59...

  3. Dynamic Fault Detection Chassis

    SciTech Connect (OSTI)

    Mize, Jeffery J

    2007-01-01

    Abstract The high frequency switching megawatt-class High Voltage Converter Modulator (HVCM) developed by Los Alamos National Laboratory for the Oak Ridge National Laboratory's Spallation Neutron Source (SNS) is now in operation. One of the major problems with the modulator systems is shoot-thru conditions that can occur in a IGBTs H-bridge topology resulting in large fault currents and device failure in a few microseconds. The Dynamic Fault Detection Chassis (DFDC) is a fault monitoring system; it monitors transformer flux saturation using a window comparator and dV/dt events on the cathode voltage caused by any abnormality such as capacitor breakdown, transformer primary turns shorts, or dielectric breakdown between the transformer primary and secondary. If faults are detected, the DFDC will inhibit the IGBT gate drives and shut the system down, significantly reducing the possibility of a shoot-thru condition or other equipment damaging events. In this paper, we will present system integration considerations, performance characteristics of the DFDC, and discuss its ability to significantly reduce costly down time for the entire facility.

  4. Thin-Film Fiber Optic Sensors for Power Control and Fault Detection. Final Report

    SciTech Connect (OSTI)

    Duncan, Paul Grems

    2003-09-30

    Described is the development of an optical current measurement device, an active power conditioning system, and sol gel type thin films for the detection of magnetic fields.

  5. Nucleic acid detection system and method for detecting influenza

    DOE Patents [OSTI]

    Cai, Hong; Song, Jian

    2015-03-17

    The invention provides a rapid, sensitive and specific nucleic acid detection system which utilizes isothermal nucleic acid amplification in combination with a lateral flow chromatographic device, or DNA dipstick, for DNA-hybridization detection. The system of the invention requires no complex instrumentation or electronic hardware, and provides a low cost nucleic acid detection system suitable for highly sensitive pathogen detection. Hybridization to single-stranded DNA amplification products using the system of the invention provides a sensitive and specific means by which assays can be multiplexed for the detection of multiple target sequences.

  6. Hand held explosives detection system

    DOE Patents [OSTI]

    Conrad, Frank J.

    1992-01-01

    The present invention is directed to a sensitive hand-held explosives detection device capable of detecting the presence of extremely low quantities of high explosives molecules, and which is applicable to sampling vapors from personnel, baggage, cargo, etc., as part of an explosives detection system.

  7. Digital quadrature phase detection

    DOE Patents [OSTI]

    Smith, James A.; Johnson, John A.

    1992-01-01

    A system for detecting the phase of a frequency of phase modulated signal that includes digital quadrature sampling of the frequency or phase modulated signal at two times that are one quarter of a cycle of a reference signal apart, determination of the arctangent of the ratio of a first sampling of the frequency or phase modulated signal to the second sampling of the frequency or phase modulated signal, and a determination of quadrant in which the phase determination is increased by 2.pi. when the quadrant changes from the first quadrant to the fourth quadrant and decreased by 2.pi. when the quadrant changes from the fourth quadrant to the first quadrant whereby the absolute phase of the frequency or phase modulated signal can be determined using an arbitrary reference convention.

  8. Detection of gas leakage

    SciTech Connect (OSTI)

    Thornberg, Steven M; Brown, Jason

    2015-02-17

    A method of detecting leaks and measuring volumes as well as a device, the Power-free Pump Module (PPM), provides a self-contained leak test and volume measurement apparatus that requires no external sources of electrical power during leak testing or volume measurement. The PPM is a portable, pneumatically-controlled instrument capable of generating a vacuum, calibrating volumes, and performing quantitative leak tests on a closed test system or device, all without the use of alternating current (AC) power. Capabilities include the ability is to provide a modest vacuum (less than 10 Torr) using a venturi pump, perform a pressure rise leak test, measure the gas's absolute pressure, and perform volume measurements. All operations are performed through a simple rotary control valve which controls pneumatically-operated manifold valves.

  9. Arc fault detection system

    DOE Patents [OSTI]

    Jha, Kamal N.

    1999-01-01

    An arc fault detection system for use on ungrounded or high-resistance-grounded power distribution systems is provided which can be retrofitted outside electrical switchboard circuits having limited space constraints. The system includes a differential current relay that senses a current differential between current flowing from secondary windings located in a current transformer coupled to a power supply side of a switchboard, and a total current induced in secondary windings coupled to a load side of the switchboard. When such a current differential is experienced, a current travels through a operating coil of the differential current relay, which in turn opens an upstream circuit breaker located between the switchboard and a power supply to remove the supply of power to the switchboard.

  10. Arc fault detection system

    DOE Patents [OSTI]

    Jha, K.N.

    1999-05-18

    An arc fault detection system for use on ungrounded or high-resistance-grounded power distribution systems is provided which can be retrofitted outside electrical switchboard circuits having limited space constraints. The system includes a differential current relay that senses a current differential between current flowing from secondary windings located in a current transformer coupled to a power supply side of a switchboard, and a total current induced in secondary windings coupled to a load side of the switchboard. When such a current differential is experienced, a current travels through a operating coil of the differential current relay, which in turn opens an upstream circuit breaker located between the switchboard and a power supply to remove the supply of power to the switchboard. 1 fig.

  11. Detection of gas leakage

    DOE Patents [OSTI]

    Thornberg, Steven; Brown, Jason

    2012-06-19

    A method of detecting leaks and measuring volumes as well as an apparatus, the Power-free Pump Module (PPM), that is a self-contained leak test and volume measurement apparatus that requires no external sources of electrical power during leak testing or volume measurement, where the invention is a portable, pneumatically-controlled instrument capable of generating a vacuum, calibrating volumes, and performing quantitative leak tests on a closed test system or device, all without the use of alternating current (AC) power. Capabilities include the ability is to provide a modest vacuum (less than 10 Torr), perform a pressure rise leak test, measure the gas's absolute pressure, and perform volume measurements. All operations are performed through a simple rotary control valve which controls pneumatically-operated manifold valves.

  12. Detection of anomalous events

    DOE Patents [OSTI]

    Ferragut, Erik M.; Laska, Jason A.; Bridges, Robert A.

    2016-06-07

    A system is described for receiving a stream of events and scoring the events based on anomalousness and maliciousness (or other classification). The system can include a plurality of anomaly detectors that together implement an algorithm to identify low-probability events and detect atypical traffic patterns. The anomaly detector provides for comparability of disparate sources of data (e.g., network flow data and firewall logs.) Additionally, the anomaly detector allows for regulatability, meaning that the algorithm can be user configurable to adjust a number of false alerts. The anomaly detector can be used for a variety of probability density functions, including normal Gaussian distributions, irregular distributions, as well as functions associated with continuous or discrete variables.

  13. RADIATION WAVE DETECTION

    DOE Patents [OSTI]

    Wouters, L.F.

    1960-08-30

    Radiation waves can be detected by simultaneously measuring radiation- wave intensities at a plurality of space-distributed points and producing therefrom a plot of the wave intensity as a function of time. To this end. a detector system is provided which includes a plurality of nuclear radiation intensity detectors spaced at equal radial increments of distance from a source of nuclear radiation. Means are provided to simultaneously sensitize the detectors at the instant a wave of radiation traverses their positions. the detectors producing electrical pulses indicative of wave intensity. The system further includes means for delaying the pulses from the detectors by amounts proportional to the distance of the detectors from the source to provide an indication of radiation-wave intensity as a function of time.

  14. Malware detection and analysis

    DOE Patents [OSTI]

    Chiang, Ken; Lloyd, Levi; Crussell, Jonathan; Sanders, Benjamin; Erickson, Jeremy Lee; Fritz, David Jakob

    2016-03-22

    Embodiments of the invention describe systems and methods for malicious software detection and analysis. A binary executable comprising obfuscated malware on a host device may be received, and incident data indicating a time when the binary executable was received and identifying processes operating on the host device may be recorded. The binary executable is analyzed via a scalable plurality of execution environments, including one or more non-virtual execution environments and one or more virtual execution environments, to generate runtime data and deobfuscation data attributable to the binary executable. At least some of the runtime data and deobfuscation data attributable to the binary executable is stored in a shared database, while at least some of the incident data is stored in a private, non-shared database.

  15. Waveguide disturbance detection method

    DOE Patents [OSTI]

    Korneev, Valeri A.; Nihei, Kurt T.; Myer, Larry R.

    2000-01-01

    A method for detection of a disturbance in a waveguide comprising transmitting a wavefield having symmetric and antisymmetric components from a horizontally and/or vertically polarized source and/or pressure source disposed symmetrically with respect to the longitudinal central axis of the waveguide at one end of the waveguide, recording the horizontal and/or vertical component or a pressure of the wavefield with a vertical array of receivers disposed at the opposite end of the waveguide, separating the wavenumber transform of the wavefield into the symmetric and antisymmetric components, integrating the symmetric and antisymmetric components over a broad frequency range, and comparing the magnitude of the symmetric components and the antisymmetric components to an expected magnitude for the symmetric components and the antisymmetric components for a waveguide of uniform thickness and properties thereby determining whether or not a disturbance is present inside the waveguide.

  16. Weld failure detection

    DOE Patents [OSTI]

    Pennell, William E.; Sutton, Jr., Harry G.

    1981-01-01

    Method and apparatus for detecting failure in a welded connection, particrly applicable to not readily accessible welds such as those joining components within the reactor vessel of a nuclear reactor system. A preselected tag gas is sealed within a chamber which extends through selected portions of the base metal and weld deposit. In the event of a failure, such as development of a crack extending from the chamber to an outer surface, the tag gas is released. The environment about the welded area is directed to an analyzer which, in the event of presence of the tag gas, evidences the failure. A trigger gas can be included with the tag gas to actuate the analyzer.

  17. Portable outgas detection apparatus

    DOE Patents [OSTI]

    Haney, Steven Julian; Malinowski, Michael E.

    2004-05-11

    A portable device for detecting surface outgas contaminants of an article includes: (i) a portable housing that has a chamber which is in communication with a port that is adapted to be sealably attached to a surface of the article; (ii) a mass spectrometer that is coupled to the chamber for analyzing gaseous materials in the chamber; and (iii) means for generating a vacuum within the chamber thereby drawing outgas contaminants from the surface of the article into the chamber for analysis by the mass spectrometer. By performing a mass spectrometric analysis of the surface of interest and comparing the data with mass spectrometric data ascertained with the device from a clean surface, the type and amount of outgas contaminants, if any, can be determined.

  18. Target detection portal

    DOE Patents [OSTI]

    Linker, Kevin L.; Brusseau, Charles A.

    2002-01-01

    A portal apparatus for screening persons or objects for the presence of trace amounts of target substances such as explosives, narcotics, radioactive materials, and certain chemical materials. The portal apparatus can have a one-sided exhaust for an exhaust stream, an interior wall configuration with a concave-shape across a horizontal cross-section for each of two facing sides to result in improved airflow and reduced washout relative to a configuration with substantially flat parallel sides; air curtains to reduce washout; ionizing sprays to collect particles bound by static forces, as well as gas jet nozzles to dislodge particles bound by adhesion to the screened person or object. The portal apparatus can be included in a detection system with a preconcentrator and a detector.

  19. Digital quadrature phase detection

    DOE Patents [OSTI]

    Smith, J.A.; Johnson, J.A.

    1992-05-26

    A system for detecting the phase of a frequency or phase modulated signal that includes digital quadrature sampling of the frequency or phase modulated signal at two times that are one quarter of a cycle of a reference signal apart, determination of the arctangent of the ratio of a first sampling of the frequency or phase modulated signal to the second sampling of the frequency or phase modulated signal, and a determination of quadrant in which the phase determination is increased by 2[pi] when the quadrant changes from the first quadrant to the fourth quadrant and decreased by 2[pi] when the quadrant changes from the fourth quadrant to the first quadrant whereby the absolute phase of the frequency or phase modulated signal can be determined using an arbitrary reference convention. 6 figs.

  20. Detection of phenols using engineered bacteria

    DOE Patents [OSTI]

    Wise, Arlene A.; Kuske, Cheryl R.; Terwilliger, Thomas C.

    2004-08-10

    Detection of phenols using engineered bacteria. A biosensor can be created by placing a reporter gene under control of an inducible promoter. The reporter gene produces a signal when a cognate transcriptional activator senses the inducing chemical. Creation of bacterial biosensors is currently restricted by limited knowledge of the genetic systems of bacteria that catabolize xenobiotics. By using mutagenic PCR to change the chemical specificity of the Pseudomonas species CF600 DmpR protein, the potential for engineering novel biosensors for detection of phenols has been demonstrated. DmpR, a well-characterized transcriptional activator of the P. CF600's dmp operon mediates growth on simple phenols. Transcription from Po, the promoter heading the dmp operon, is activated when the sensor domain of DmpR interacts with phenol and mono-substituted phenols. By altering the sensor domain of the DmpR, a group of DmpR derivatives that activate transcription of a Po-lacZ fusion in response to eight of the EPA's eleven priority pollutant phenols has been created. The assays and the sensor domain mutations that alter the chemical specificity of DmpR is described.

  1. Detection of phenols using engineered bacteria

    DOE Patents [OSTI]

    Wise, Arlene A.; Kuske, Cheryl R.; Terwilliger, Thomas C.

    2007-12-04

    Detection of phenols using engineered bacteria. A biosensor can be created by placing a reporter gene under control of an inducible promoter. The reporter gene produces a signal when a cognate transcriptional activator senses the inducing chemical. Creation of bacterial biosensors is currently restricted by limited knowledge of the genetic systems of bacteria that catabolize xenobiotics. By using mutagenic PCR to change the chemical specificity of the Pseudomonas species CF600 DmpR protein, the potential for engineering novel biosensors for detection of phenols has been demonstrated. DmpR, a well-characterized transcriptional activator of the P. CF600's dmp operon mediates growth on simple phenols. Transcription from Po, the promoter heading the dmp operon, is activated when the sensor domain of DmpR interacts with phenol and mono-substituted phenols. By altering the sensor domain of the DmpR, a group of DmpR derivatives that activate transcription of a Po-lacZ fusion in response to eight of the EPA's eleven priority pollutant phenols has been created. The assays and the sensor domain mutations that alter the chemical specificity of DmpR is described.

  2. Improved Microseismicity Detection During Newberry EGS Stimulations

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Templeton, Dennise

    2013-11-01

    Effective enhanced geothermal systems (EGS) require optimal fracture networks for efficient heat transfer between hot rock and fluid. Microseismic mapping is a key tool used to infer the subsurface fracture geometry. Traditional earthquake detection and location techniques are often employed to identify microearthquakes in geothermal regions. However, most commonly used algorithms may miss events if the seismic signal of an earthquake is small relative to the background noise level or if a microearthquake occurs within the coda of a larger event. Consequently, we have developed a set of algorithms that provide improved microearthquake detection. Our objective is to investigate the microseismicity at the DOE Newberry EGS site to better image the active regions of the underground fracture network during and immediately after the EGS stimulation. Detection of more microearthquakes during EGS stimulations will allow for better seismic delineation of the active regions of the underground fracture system. This improved knowledge of the reservoir network will improve our understanding of subsurface conditions, and allow improvement of the stimulation strategy that will optimize heat extraction and maximize economic return.

  3. Improved Microseismicity Detection During Newberry EGS Stimulations

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Templeton, Dennise

    2013-10-01

    Effective enhanced geothermal systems (EGS) require optimal fracture networks for efficient heat transfer between hot rock and fluid. Microseismic mapping is a key tool used to infer the subsurface fracture geometry. Traditional earthquake detection and location techniques are often employed to identify microearthquakes in geothermal regions. However, most commonly used algorithms may miss events if the seismic signal of an earthquake is small relative to the background noise level or if a microearthquake occurs within the coda of a larger event. Consequently, we have developed a set of algorithms that provide improved microearthquake detection. Our objective is to investigate the microseismicity at the DOE Newberry EGS site to better image the active regions of the underground fracture network during and immediately after the EGS stimulation. Detection of more microearthquakes during EGS stimulations will allow for better seismic delineation of the active regions of the underground fracture system. This improved knowledge of the reservoir network will improve our understanding of subsurface conditions, and allow improvement of the stimulation strategy that will optimize heat extraction and maximize economic return.

  4. Improved Microseismicity Detection During Newberry EGS Stimulations

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Templeton, Dennise

    Effective enhanced geothermal systems (EGS) require optimal fracture networks for efficient heat transfer between hot rock and fluid. Microseismic mapping is a key tool used to infer the subsurface fracture geometry. Traditional earthquake detection and location techniques are often employed to identify microearthquakes in geothermal regions. However, most commonly used algorithms may miss events if the seismic signal of an earthquake is small relative to the background noise level or if a microearthquake occurs within the coda of a larger event. Consequently, we have developed a set of algorithms that provide improved microearthquake detection. Our objective is to investigate the microseismicity at the DOE Newberry EGS site to better image the active regions of the underground fracture network during and immediately after the EGS stimulation. Detection of more microearthquakes during EGS stimulations will allow for better seismic delineation of the active regions of the underground fracture system. This improved knowledge of the reservoir network will improve our understanding of subsurface conditions, and allow improvement of the stimulation strategy that will optimize heat extraction and maximize economic return.

  5. Incipient fire detection system

    DOE Patents [OSTI]

    Brooks, Jr., William K.

    1999-01-01

    A method and apparatus for an incipient fire detection system that receives gaseous samples and measures the light absorption spectrum of the mixture of gases evolving from heated combustibles includes a detector for receiving gaseous samples and subjecting the samples to spectroscopy and determining wavelengths of absorption of the gaseous samples. The wavelengths of absorption of the gaseous samples are compared to predetermined absorption wavelengths. A warning signal is generated whenever the wavelengths of absorption of the gaseous samples correspond to the predetermined absorption wavelengths. The method includes receiving gaseous samples, subjecting the samples to light spectroscopy, determining wavelengths of absorption of the gaseous samples, comparing the wavelengths of absorption of the gaseous samples to predetermined absorption wavelengths and generating a warning signal whenever the wavelengths of absorption of the gaseous samples correspond to the predetermined absorption wavelengths. In an alternate embodiment, the apparatus includes a series of channels fluidically connected to a plurality of remote locations. A pump is connected to the channels for drawing gaseous samples into the channels. A detector is connected to the channels for receiving the drawn gaseous samples and subjecting the samples to spectroscopy. The wavelengths of absorption are determined and compared to predetermined absorption wavelengths is provided. A warning signal is generated whenever the wavelengths correspond.

  6. detection | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    detection Researcher from NNSA lab helps develop new system for instant explosive detection Chemicals used in explosives give off signatures that can be read by spectroscopic systems. One practical application for this technology would be for use at airport screening stations. A spectroscopic detection system would be able to tell the difference between explosive chemicals and shampoo by... Sniffing out danger from above NNSA's efforts to prevent, counter, and respond to the dangers of nuclear

  7. Method for detecting an element

    DOE Patents [OSTI]

    Blackwood, Larry G.; Reber, Edward L.; Rohde, Kenneth W.

    2007-02-06

    A method for detecting an element is disclosed and which includes the steps of providing a gamma-ray spectrum which depicts, at least in part, a test region having boundaries, and which has a small amount of the element to be detected; providing a calculation which detects the small amount of the element to be detected; and providing a moving window and performing the calculation within the moving window, and over a range of possible window boundaries within the test region to determine the location of the optimal test region within the gamma-ray spectrum.

  8. Vision-based threat detection in dynamic environments.

    SciTech Connect (OSTI)

    Carlson, Jeffrey J.

    2007-08-01

    This report addresses the development of automated video-screening technology to assist security forces in protecting our homeland against terrorist threats. A prevailing threat is the covert placement of bombs inside crowded public facilities. Although video-surveillance systems are increasingly common, current systems cannot detect the placement of bombs. It is also unlikely that security personnel could detect a bomb or its placement by observing video from surveillance cameras. The problems lie in the large number of cameras required to monitor large areas, the limited number of security personnel employed to protect these areas, and the intense diligence required to effectively screen live video from even a single camera. Different from existing video-detection systems designed to operate in nearly static environments, we are developing technology to detect changes in the background of dynamic environments: environments where motion and human activities are persistent over long periods. Our goal is to quickly detect background changes, even if the background is visible to the camera less than 5 percent of the time and possibly never free from foreground activity. Our approach employs statistical scene models based on mixture densities. We hypothesized that the background component of the mixture has a small variance compared to foreground components. Experiments demonstrate this hypothesis is true under a wide variety of operating conditions. A major focus involved the development of robust background estimation techniques that exploit this property. We desire estimation algorithms that can rapidly produce accurate background estimates and detection algorithms that can reliably detect background changes with minimal nuisance alarms. Another goal is to recognize unusual activities or foreground conditions that could signal an attack (e.g., large numbers of running people, people falling to the floor, etc.). Detection of background changes and/or unusual

  9. Detecting the climatic effects of increasing carbon dioxide

    SciTech Connect (OSTI)

    MacCracken, M C; Luther, F M

    1985-12-01

    This report documents what is known about detecting the CO2-induced changes in climate, and describes the uncertainties and unknowns associated with this monitoring and analysis effort. The various approaches for detecting CO2-induced climate changes are discussed first, followed by a review of applications of these strategies to the various climatic variables that are expected to be changing. Recommendations are presented for research and analysis activities. Separate abstracts have been prepared for the individual papers. (ACR)

  10. Computational Method for Detecting and Enhancing Protein Dynamics - Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Innovation Portal Energy Analysis Energy Analysis Biomass and Biofuels Biomass and Biofuels Find More Like This Return to Search Computational Method for Detecting and Enhancing Protein Dynamics Oak Ridge National Laboratory Contact ORNL About This Technology Technology Marketing SummaryORNL researchers have developed a method that uses simulation and experimental data to detect, analyze, and manipulate protein activity. This approach enables enhancement of the chemical reaction rates of

  11. Methods and systems for remote detection of gases

    DOE Patents [OSTI]

    Johnson, Timothy J.

    2007-11-27

    Novel systems and methods for remotely detecting at least one constituent of a gas via infrared detection are provided. A system includes at least one extended source of broadband infrared radiation and a spectrally sensitive receiver positioned remotely from the source. The source and the receiver are oriented such that a surface of the source is in the field of view of the receiver. The source includes a heating component thermally coupled to the surface, and the heating component is configured to heat the surface to a temperature above ambient temperature. The receiver is operable to collect spectral infrared absorption data representative of a gas present between the source and the receiver. The invention advantageously overcomes significant difficulties associated with active infrared detection techniques known in the art, and provides an infrared detection technique with a much greater sensitivity than passive infrared detection techniques known in the art.

  12. Methods and systems for remote detection of gases

    DOE Patents [OSTI]

    Johnson, Timothy J

    2012-09-18

    Novel systems and methods for remotely detecting at least one constituent of a gas via infrared detection are provided. A system includes at least one extended source of broadband infrared radiation and a spectrally sensitive receiver positioned remotely from the source. The source and the receiver are oriented such that a surface of the source is in the field of view of the receiver. The source includes a heating component thermally coupled to the surface, and the heating component is configured to heat the surface to a temperature above ambient temperature. The receiver is operable to collect spectral infrared absorption data representative of a gas present between the source and the receiver. The invention advantageously overcomes significant difficulties associated with active infrared detection techniques known in the art, and provides an infrared detection technique with a much greater sensitivity than passive infrared detection techniques known in the art.

  13. MPI Runtime Error Detection with MUST: Advances in Deadlock Detection

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hilbrich, Tobias; Protze, Joachim; Schulz, Martin; de Supinski, Bronis R.; MĂĽller, Matthias S.

    2013-01-01

    The widely used Message Passing Interface (MPI) is complex and rich. As a result, application developers require automated tools to avoid and to detect MPI programming errors. We present the Marmot Umpire Scalable Tool (MUST) that detects such errors with significantly increased scalability. We present improvements to our graph-based deadlock detection approach for MPI, which cover future MPI extensions. Our enhancements also check complex MPI constructs that no previous graph-based detection approach handled correctly. Finally, we present optimizations for the processing of MPI operations that reduce runtime deadlock detection overheads. Existing approaches often require 𝒪( p ) analysis timemore » per MPI operation, for p processes. We empirically observe that our improvements lead to sub-linear or better analysis time per operation for a wide range of real world applications.« less

  14. Detection of alpha radiation in a beta radiation field

    DOE Patents [OSTI]

    Mohagheghi, Amir H.; Reese, Robert P.

    2001-01-01

    An apparatus and method for detecting alpha particles in the presence of high activities of beta particles utilizing an alpha spectrometer. The apparatus of the present invention utilizes a magnetic field applied around the sample in an alpha spectrometer to deflect the beta particles from the sample prior to reaching the detector, thus permitting detection of low concentrations of alpha particles. In the method of the invention, the strength of magnetic field required to adequately deflect the beta particles and permit alpha particle detection is given by an algorithm that controls the field strength as a function of sample beta energy and the distance of the sample to the detector.

  15. Active Fault Controls At High-Temperature Geothermal Sites- Prospectin...

    Open Energy Info (EERE)

    model in which recently active (Holocene) faults are preferred conduits for migration of thermal water from deep crustal depths, and we infer that the detection of sites...

  16. Particle detection systems and methods

    DOE Patents [OSTI]

    Morris, Christopher L.; Makela, Mark F.

    2010-05-11

    Techniques, apparatus and systems for detecting particles such as muons and neutrons. In one implementation, a particle detection system employs a plurality of drift cells, which can be for example sealed gas-filled drift tubes, arranged on sides of a volume to be scanned to track incoming and outgoing charged particles, such as cosmic ray-produced muons. The drift cells can include a neutron sensitive medium to enable concurrent counting of neutrons. The system can selectively detect devices or materials, such as iron, lead, gold, uranium, plutonium, and/or tungsten, occupying the volume from multiple scattering of the charged particles passing through the volume and can concurrently detect any unshielded neutron sources occupying the volume from neutrons emitted therefrom. If necessary, the drift cells can be used to also detect gamma rays. The system can be employed to inspect occupied vehicles at border crossings for nuclear threat objects.

  17. Portable reconfigurable detection and assessment system; MODAS update

    SciTech Connect (OSTI)

    Blattman, D.A. )

    1991-01-01

    Rapidly changing geopolitical issues throughout the world have made the ability to effectively respond to political, military, terrorist and peace-keeping requirements increasingly important. Recent Middle East events indicate a continuing escalation in these activities. These activities are defining the requirements for a rapidly deployable, portable, real-time detection and assessment operational security system that is reconfigurable to site specific threats. This paper describes such a system Mobile Operational Detection and Assessment system (MODAS); a commercially-off-the shelf (COTS) integrated and reconfigurable hardware/software system solution for the ever-changing geopolitical security issues of the Nineties.

  18. Detection and Classification of Buried Metallic Objects UX-1225

    SciTech Connect (OSTI)

    Morrison, Frank; Smith, Torquil; Becker, Alex; Gasperikova, Erika

    2005-03-31

    In summary the technical objectives of this project were: (1) To develop and demonstrate a methodology for the quantitative evaluation of existing active electromagnetic (AEM) systems and for the design of new systems. (2) To implement a new methodology for optimizing an AEM system for detecting and classifying UXO of a given class in a specified geologic setting and in a given noise environment. (3) To design and build a prototype of an active EM system for detecting and characterizing a metallic object in the ground.

  19. Amplification of Xenon NMR and MRI by remote detection

    SciTech Connect (OSTI)

    Moule, Adam J.; Spence, Megan M.; Han, Song-I.; Seeley, JulietteA.; Pierce, Kimberly L.; Saxena, Sunil; Pines, Alexander

    2003-03-31

    A novel technique is proposed in which a nuclear magneticresonance (NMR) spectrum or magnetic resonance image (MRI) is encoded andstored as spin polarization and is then moved to a different physicallocation to be detected. Remote detection allows the separateoptimization of the encoding and detection steps, permitting theindependent choice of experimental conditions, and excitation anddetection methodologies. In the first experimental demonstration of thistechnique, we show that NMR signal can be amplified by taking diluted129Xe from a porous sample placed inside a large encoding coil, andconcentrating it into a smaller detection coil. In general, the study ofNMR active molecules at low concentration that have low physical fillingfactor is facilitated by remote detection. In the second experiment, MRIinformation encoded in a very low field magnet (4-7mT) is transferred toa high field magnet (4.2 T) in order to be detected under optimizedconditions. Furthermore, remote detection allows the utilization ofultra-sensitive optical or superconducting detection techniques, whichbroadens the horizon of NMR experimentation.

  20. Catalyst activator

    DOE Patents [OSTI]

    McAdon, Mark H.; Nickias, Peter N.; Marks, Tobin J.; Schwartz, David J.

    2001-01-01

    A catalyst activator particularly adapted for use in the activation of metal complexes of metals of Group 3-10 for polymerization of ethylenically unsaturated polymerizable monomers, especially olefins, comprising two Group 13 metal or metalloid atoms and a ligand structure including at least one bridging group connecting ligands on the two Group 13 metal or metalloid atoms.

  1. Method For Detecting Biological Agents

    DOE Patents [OSTI]

    Chen, Liaohai; McBranch, Duncan W.; Wang, Hsing-Lin; Whitten, David G.

    2005-12-27

    A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate combination of a recognition element, a tethering element and a property-altering element bound thereto and capable of altering the measurable property, the intermediate combination adapted for subsequent separation from the polymer upon exposure to an agent having an affinity for binding to the recognition element whereupon the separation of the intermediate combination from the polymer results in a detectable change in the alterable measurable property, and, detecting said detectable change in the alterable measurable property.

  2. Current Trends in Gamma Radiation Detection for Radiological Emergency Response

    SciTech Connect (OSTI)

    Mukhopadhyay, S., Guss, P., Maurer, R.

    2011-09-01

    Passive and active detection of gamma rays from shielded radioactive materials, including special nuclear materials, is an important task for any radiological emergency response organization. This article reports on the current trends and status of gamma radiation detection objectives and measurement techniques as applied to nonproliferation and radiological emergencies. In recent years, since the establishment of the Domestic Nuclear Detection Office by the Department of Homeland Security, a tremendous amount of progress has been made in detection materials (scintillators, semiconductors), imaging techniques (Compton imaging, use of active masking and hybrid imaging), data acquisition systems with digital signal processing, field programmable gate arrays and embedded isotopic analysis software (viz. gamma detector response and analysis software [GADRAS]1), fast template matching, and data fusion (merging radiological data with geo-referenced maps, digital imagery to provide better situational awareness). In this stride to progress, a significant amount of interdisciplinary research and development has taken place–techniques and spin-offs from medical science (such as x-ray radiography and tomography), materials engineering (systematic planned studies on scintillators to optimize several qualities of a good scintillator, nanoparticle applications, quantum dots, and photonic crystals, just to name a few). No trend analysis of radiation detection systems would be complete without mentioning the unprecedented strategic position taken by the National Nuclear Security Administration (NNSA) to deter, detect, and interdict illicit trafficking in nuclear and other radioactive materials across international borders and through the global maritime transportation–the so-called second line of defense.

  3. Detection of nucleic acids by multiple sequential invasive cleavages 02

    DOE Patents [OSTI]

    Hall, Jeff G.; Lyamichev, Victor I.; Mast, Andrea L.; Brow, Mary Ann D.

    2002-01-01

    The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. The present invention further relates to methods and devices for the separation of nucleic acid molecules based on charge. The present invention also provides methods for the detection of non-target cleavage products via the formation of a complete and activated protein binding region. The invention further provides sensitive and specific methods for the detection of human cytomegalovirus nucleic acid in a sample.

  4. Detection of nucleic acids by multiple sequential invasive cleavages

    DOE Patents [OSTI]

    Hall, Jeff G.; Lyamichev, Victor I.; Mast, Andrea L.; Brow, Mary Ann D.

    1999-01-01

    The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. The present invention further relates to methods and devices for the separation of nucleic acid molecules based on charge. The present invention also provides methods for the detection of non-target cleavage products via the formation of a complete and activated protein binding region. The invention further provides sensitive and specific methods for the detection of human cytomegalovirus nucleic acid in a sample.

  5. Detection of nucleic acids by multiple sequential invasive cleavages

    DOE Patents [OSTI]

    Hall, Jeff G; Lyamichev, Victor I; Mast, Andrea L; Brow, Mary Ann D

    2012-10-16

    The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. The present invention further relates to methods and devices for the separation of nucleic acid molecules based on charge. The present invention also provides methods for the detection of non-target cleavage products via the formation of a complete and activated protein binding region. The invention further provides sensitive and specific methods for the detection of human cytomegalovirus nucleic acid in a sample.

  6. T Plant secondary containment and leak detection upgrades

    SciTech Connect (OSTI)

    Carlson, T.A.

    1995-10-19

    The W-259 project will provide upgrades to the 2706-T/TA Facility to comply with Federal and State of Washington environmental regulations for secondary containment and leak detection. The project provides decontamination activities supporting the environmental restoration mission and waste management operations on the Hanford Site.

  7. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer

    SciTech Connect (OSTI)

    Purcell, James W; Davis, Jefferson; Reddy, Mamatha; Martin, Shamra; Samayoa, Kimberly; Vo, Hung; Thomsen, Karen; Bean, Peter; Kuo, Wen Lin; Ziyad, Safiyyah; Billig, Jessica; Feiler, Heidi S; Gray, Joe W; Wood, Kenneth W; Cases, Sylvaine

    2009-06-10

    Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein (KSP), a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. Clinical studies of ispinesib have demonstrated a 9% response rate in patients with locally advanced or metastatic breast cancer, and a favorable safety profile without significant neurotoxicities, gastrointestinal toxicities or hair loss. To better understand the potential of ispinesib in the treatment of breast cancer we explored the activity of ispinesib alone and in combination several therapies approved for the treatment of breast cancer. We measured the ispinesib sensitivity and pharmacodynamic response of breast cancer cell lines representative of various subtypes in vitro and as xenografts in vivo, and tested the ability of ispinesib to enhance the anti-tumor activity of approved therapies. In vitro, ispinesib displayed broad anti-proliferative activity against a panel of 53 breast cell-lines. In vivo, ispinesib produced regressions in each of five breast cancer models, and tumor free survivors in three of these models. The effects of ispinesib treatment on pharmacodynamic markers of mitosis and apoptosis were examined in vitro and in vivo, revealing a greater increase in both mitotic and apoptotic markers in the MDA-MB-468 model than in the less sensitive BT-474 model. In vivo, ispinesib enhanced the anti-tumor activity of trastuzumab, lapatinib, doxorubicin, and capecitabine, and exhibited activity comparable to paclitaxel and ixabepilone. These findings support further clinical exploration of KSP inhibitors for the treatment of breast cancer.

  8. Radio frequency detection assembly and method for detecting radio frequencies

    DOE Patents [OSTI]

    Cown, Steven H.; Derr, Kurt Warren

    2010-03-16

    A radio frequency detection assembly is described and which includes a radio frequency detector which detects a radio frequency emission produced by a radio frequency emitter from a given location which is remote relative to the radio frequency detector; a location assembly electrically coupled with the radio frequency detector and which is operable to estimate the location of the radio frequency emitter from the radio frequency emission which has been received; and a radio frequency transmitter electrically coupled with the radio frequency detector and the location assembly, and which transmits a radio frequency signal which reports the presence of the radio frequency emitter.

  9. Functionalized active-nucleus complex sensor

    DOE Patents [OSTI]

    Pines, Alexander; Wemmer, David E.; Spence, Megan; Rubin, Seth

    2003-11-25

    A functionalized active-nucleus complex sensor that selectively associates with one or more target species, and a method for assaying and screening for one or a plurality of target species utilizing one or a plurality of functionalized active-nucleus complexes with at least two of the functionalized active-nucleus complexes having an attraction affinity to different corresponding target species. The functionalized active-nucleus complex has an active-nucleus and a targeting carrier. The method involves functionalizing an active-nucleus, for each functionalized active-nucleus complex, by incorporating the active-nucleus into a macromolucular or molecular complex that is capable of binding one of the target species and then bringing the macromolecular or molecular complexes into contact with the target species and detecting the occurrence of or change in a nuclear magnetic resonance signal from each of the active-nuclei in each of the functionalized active-nucleus complexes.

  10. Method and apparatus for enhanced detection of toxic agents

    DOE Patents [OSTI]

    Greenbaum, Elias; Rodriguez, Jr., Miguel; Wu, Jie Jayne; Qi, Hairong

    2012-06-12

    A water quality analyzer for real-time detection according to the invention comprises a biased AC electro-osmosis (ACEO) cell for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region, wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.

  11. Optically detected magnetic resonance imaging

    SciTech Connect (OSTI)

    Blank, Aharon; Shapiro, Guy; Fischer, Ran; London, Paz; Gershoni, David

    2015-01-19

    Optically detected magnetic resonance provides ultrasensitive means to detect and image a small number of electron and nuclear spins, down to the single spin level with nanoscale resolution. Despite the significant recent progress in this field, it has never been combined with the power of pulsed magnetic resonance imaging techniques. Here, we demonstrate how these two methodologies can be integrated using short pulsed magnetic field gradients to spatially encode the sample. This result in what we denote as an 'optically detected magnetic resonance imaging' technique. It offers the advantage that the image is acquired in parallel from all parts of the sample, with well-defined three-dimensional point-spread function, and without any loss of spectroscopic information. In addition, this approach may be used in the future for parallel but yet spatially selective efficient addressing and manipulation of the spins in the sample. Such capabilities are of fundamental importance in the field of quantum spin-based devices and sensors.

  12. Discriminating ultrasonic proximity detection system

    DOE Patents [OSTI]

    Annala, Wayne C.

    1989-01-01

    This invention uses an ultrasonic transmitter and receiver and a microprocessor to detect the presence of an object. In the reset mode the invention uses a plurality of echoes from each ultrasonic burst to create a reference table of the echo-burst-signature of the empty monitored environment. The invention then processes the reference table so that it only uses the most reliable data. In the detection mode the invention compares the echo-burst-signature of the present environment with the reference table, detecting an object if there is a consistent difference between the echo-burst-signature of the empty monitored environment recorded in the reference table and the echo-burst-signature of the present environment.

  13. GMTI radar minimum detectable velocity.

    SciTech Connect (OSTI)

    Richards, John Alfred

    2011-04-01

    Minimum detectable velocity (MDV) is a fundamental consideration for the design, implementation, and exploitation of ground moving-target indication (GMTI) radar imaging modes. All single-phase-center air-to-ground radars are characterized by an MDV, or a minimum radial velocity below which motion of a discrete nonstationary target is indistinguishable from the relative motion between the platform and the ground. Targets with radial velocities less than MDV are typically overwhelmed by endoclutter ground returns, and are thus not generally detectable. Targets with radial velocities greater than MDV typically produce distinct returns falling outside of the endoclutter ground returns, and are thus generally discernible using straightforward detection algorithms. This document provides a straightforward derivation of MDV for an air-to-ground single-phase-center GMTI radar operating in an arbitrary geometry.

  14. Point pattern match-based change detection in a constellation of previously detected objects

    DOE Patents [OSTI]

    Paglieroni, David W.

    2016-06-07

    A method and system is provided that applies attribute- and topology-based change detection to objects that were detected on previous scans of a medium. The attributes capture properties or characteristics of the previously detected objects, such as location, time of detection, detection strength, size, elongation, orientation, etc. The locations define a three-dimensional network topology forming a constellation of previously detected objects. The change detection system stores attributes of the previously detected objects in a constellation database. The change detection system detects changes by comparing the attributes and topological consistency of newly detected objects encountered during a new scan of the medium to previously detected objects in the constellation database. The change detection system may receive the attributes of the newly detected objects as the objects are detected by an object detection system in real time.

  15. Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and ?-catenin signaling pathway

    SciTech Connect (OSTI)

    Li, Hongzhong; Huang, Jing; Yang, Bing; Xiang, Tingxiu; Yin, Xuedong; Peng, Weiyan; Cheng, Wei; Wan, Jingyuan; Luo, Fuling; Li, Hongyuan; Ren, Guosheng

    2013-10-01

    Although mangiferin which is a naturally occurring glucosylxanthone has exhibited promising anticancer activities, the detailed molecular mechanism of mangiferin on cancers still remains enigmatic. In this study, the anticancer activity of mangiferin was evaluated in breast cancer cell line-based in vitro and in vivo models. We showed that mangiferin treatment resulted in decreased cell viability and suppression of metastatic potential in breast cancer cells. Further mechanistic investigation revealed that mangiferin induced decreased matrix metalloproteinase (MMP)-7 and -9, and reversal of epithelial–mesenchymal transition (EMT). Moreover, it was demonstrated that mangiferin significantly inhibited the activation of ?-catenin pathway. Subsequent experiments showed that inhibiting ?-catenin pathway might play a central role in mangiferin-induced anticancer activity through modulation of MMP-7 and -9, and EMT. Consistent with these findings in vitro, the antitumor potential was also verified in mangiferin-treated MDA-MB-231 xenograft mice where significantly decreased tumor volume, weight and proliferation, and increased apoptosis were obtained, with lower expression of MMP-7 and -9, vimentin and active ?-catenin, and higher expression of E-cadherin. Taken together, our study suggests that mangiferin might be used as an effective chemopreventive agent against breast cancer. - Highlights: • Mangiferin inhibits growth and metastatic potential in breast cancer cells. • Mangiferin down-regulates MMP-7 and -9 in breast cancer cells. • Mangiferin induces the reversal of EMT in metastatic breast cancer cells. • Mangiferin inhibits the activation of ?-catenin pathway in breast cancer cells. • Inhibiting ?-catenin is responsible for the antitumor activity of mangiferin.

  16. Activity report

    SciTech Connect (OSTI)

    Yu, S W

    2008-08-11

    This report is aimed to show the author's activities to support the LDRD. The title is 'Investigation of the Double-C Behavior in the Pu-Ga Time-Temperature-Transformation Diagram' The sections are: (1) Sample Holder Test; (2) Calculation of x-ray diffraction patterns; (3) Literature search and preparing publications; (4) Tasks Required for APS Experiments; and (5) Communications.

  17. Using Commercial Electronics in Nuclear Detection (Conference...

    Office of Scientific and Technical Information (OSTI)

    Conference: Using Commercial Electronics in Nuclear Detection Citation Details In-Document Search Title: Using Commercial Electronics in Nuclear Detection Authors: Quinn, Heather ...

  18. Using Commercial Electronics in Nuclear Detection (Conference...

    Office of Scientific and Technical Information (OSTI)

    Using Commercial Electronics in Nuclear Detection Citation Details In-Document Search Title: Using Commercial Electronics in Nuclear Detection You are accessing a document from ...

  19. Fluorescent Nanoparticles for Radiation DetectionFluorescent...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Find More Like This Return to Search Fluorescent Nanoparticles for Radiation DetectionFluorescent Nanoparticles for Radiation Detection Oak Ridge National Laboratory Contact ORNL ...

  20. Detection of electromagnetic radiation using micromechanical...

    Office of Scientific and Technical Information (OSTI)

    Patent: Detection of electromagnetic radiation using micromechanical multiple quantum wells structures Citation Details In-Document Search Title: Detection of electromagnetic ...

  1. System for detecting special nuclear materials

    SciTech Connect (OSTI)

    Jandel, Marian; Rusev, Gencho Yordanov; Taddeucci, Terry Nicholas

    2015-07-14

    The present disclosure includes a radiological material detector having a convertor material that emits one or more photons in response to a capture of a neutron emitted by a radiological material; a photon detector arranged around the convertor material and that produces an electrical signal in response to a receipt of a photon; and a processor connected to the photon detector, the processor configured to determine the presence of a radiological material in response to a predetermined signature of the electrical signal produced at the photon detector. One or more detectors described herein can be integrated into a detection system that is suited for use in port monitoring, treaty compliance, and radiological material management activities.

  2. Nondestructive detection and measurement of hydrogen embrittlement

    DOE Patents [OSTI]

    Alex, Franklin; Byrne, Joseph Gerald

    1977-01-01

    A nondestructive system and method for the determination of the presence and extent of hydrogen embrittlement in metals, alloys, and other crystalline structures subject thereto. Positron annihilation characteristics of the positron-electron annihilation within the tested material provide unique energy distribution curves for each type of material tested at each respective stage of hydrogen embrittlement. Gamma radiation resulting from such annihilation events is detected and statistically summarized by appropriate instrumentation to reveal the variations of electron activity within the tested material caused by hydrogen embrittlement therein. Such data from controlled tests provides a direct indication of the relative stages of hydrogen embrittlement in the form of unique energy distribution curves which may be utilized as calibration curves for future comparison with field tests to give on-site indication of progressive stages of hydrogen embrittlement.

  3. Detecting fission from special nuclear material sources

    DOE Patents [OSTI]

    Rowland, Mark S.; Snyderman, Neal J.

    2012-06-05

    A neutron detector system for discriminating fissile material from non-fissile material wherein a digital data acquisition unit collects data at high rate, and in real-time processes large volumes of data directly into information that a first responder can use to discriminate materials. The system comprises counting neutrons from the unknown source and detecting excess grouped neutrons to identify fission in the unknown source. The system includes a graphing component that displays the plot of the neutron distribution from the unknown source over a Poisson distribution and a plot of neutrons due to background or environmental sources. The system further includes a known neutron source placed in proximity to the unknown source to actively interrogate the unknown source in order to accentuate differences in neutron emission from the unknown source from Poisson distributions and/or environmental sources.

  4. Metabonomics for detection of nuclear materials processing.

    SciTech Connect (OSTI)

    Alam, Todd Michael; Luxon, Bruce A.; Neerathilingam, Muniasamy; Ansari, S.; Volk, David; Sarkar, S.; Alam, Mary Kathleen

    2010-08-01

    Tracking nuclear materials production and processing, particularly covert operations, is a key national security concern, given that nuclear materials processing can be a signature of nuclear weapons activities by US adversaries. Covert trafficking can also result in homeland security threats, most notably allowing terrorists to assemble devices such as dirty bombs. Existing methods depend on isotope analysis and do not necessarily detect chronic low-level exposure. In this project, indigenous organisms such as plants, small mammals, and bacteria are utilized as living sensors for the presence of chemicals used in nuclear materials processing. Such 'metabolic fingerprinting' (or 'metabonomics') employs nuclear magnetic resonance (NMR) spectroscopy to assess alterations in organismal metabolism provoked by the environmental presence of nuclear materials processing, for example the tributyl phosphate employed in the processing of spent reactor fuel rods to extract and purify uranium and plutonium for weaponization.

  5. Anomalous change detection in imagery

    DOE Patents [OSTI]

    Theiler, James P.; Perkins, Simon J.

    2011-05-31

    A distribution-based anomaly detection platform is described that identifies a non-flat background that is specified in terms of the distribution of the data. A resampling approach is also disclosed employing scrambled resampling of the original data with one class specified by the data and the other by the explicit distribution, and solving using binary classification.

  6. Detection of explosives in soils

    DOE Patents [OSTI]

    Chambers, William B.; Rodacy, Philip J.; Phelan, James M.; Woodfin, Ronald L.

    2002-01-01

    An apparatus and method for detecting explosive-indicating compounds in subsurface soil. The apparatus has a probe with an adsorbent material on some portion of its surface that can be placed into soil beneath the ground surface, where the adsorbent material can adsorb at least one explosive-indicating compound. The apparatus additional has the capability to desorb the explosive-indicating compound through heating or solvent extraction. A diagnostic instrument attached to the probe detects the desorbed explosive-indicating compound. In the method for detecting explosive-indicating compounds in soil, the sampling probe with an adsorbent material on at least some portion of a surface of the sampling probe is inserted into the soil to contact the adsorbent material with the soil. The explosive-indicating compounds are then desorbed and transferred as either a liquid or gas sample to a diagnostic tool for analysis. The resulting gas or liquid sample is analyzed using at least one diagnostic tool selected from the group consisting of an ion-mobility spectrometer, a gas chromatograph, a high performance liquid chromatograph, a capillary electrophoresis chromatograph, a mass spectrometer, a Fourier-transform infrared spectrometer and a Raman spectrometer to detect the presence of explosive-indicating compounds.

  7. GPU Accelerated Event Detection Algorithm

    Energy Science and Technology Software Center (OSTI)

    2011-05-25

    Smart grid external require new algorithmic approaches as well as parallel formulations. One of the critical components is the prediction of changes and detection of anomalies within the power grid. The state-of-the-art algorithms are not suited to handle the demands of streaming data analysis. (i) need for events detection algorithms that can scale with the size of data, (ii) need for algorithms that can not only handle multi dimensional nature of the data, but alsomore » model both spatial and temporal dependencies in the data, which, for the most part, are highly nonlinear, (iii) need for algorithms that can operate in an online fashion with streaming data. The GAEDA code is a new online anomaly detection techniques that take into account spatial, temporal, multi-dimensional aspects of the data set. The basic idea behind the proposed approach is to (a) to convert a multi-dimensional sequence into a univariate time series that captures the changes between successive windows extracted from the original sequence using singular value decomposition (SVD), and then (b) to apply known anomaly detection techniques for univariate time series. A key challenge for the proposed approach is to make the algorithm scalable to huge datasets by adopting techniques from perturbation theory, incremental SVD analysis. We used recent advances in tensor decomposition techniques which reduce computational complexity to monitor the change between successive windows and detect anomalies in the same manner as described above. Therefore we propose to develop the parallel solutions on many core systems such as GPUs, because these algorithms involve lot of numerical operations and are highly data-parallelizable.« less

  8. Imaging, object detection, and change detection with a polarized multistatic GPR array

    DOE Patents [OSTI]

    Beer, N. Reginald; Paglieroni, David W.

    2015-07-21

    A polarized detection system performs imaging, object detection, and change detection factoring in the orientation of an object relative to the orientation of transceivers. The polarized detection system may operate on one of several modes of operation based on whether the imaging, object detection, or change detection is performed separately for each transceiver orientation. In combined change mode, the polarized detection system performs imaging, object detection, and change detection separately for each transceiver orientation, and then combines changes across polarizations. In combined object mode, the polarized detection system performs imaging and object detection separately for each transceiver orientation, and then combines objects across polarizations and performs change detection on the result. In combined image mode, the polarized detection system performs imaging separately for each transceiver orientation, and then combines images across polarizations and performs object detection followed by change detection on the result.

  9. Bayesian Processing for the Detection of Radioactive Contraband from Uncertain Measurements

    SciTech Connect (OSTI)

    Candy, J V; Sale, K; Guidry, B; Breitfeller, E; Manatt, D; Chambers, D

    2007-06-26

    With the increase in terrorist activities throughout the world, the need to develop techniques capable of detecting radioactive contraband in a timely manner is a critical requirement. The development of Bayesian processors for the detection of contraband stems from the fact that the posterior distribution is clearly multimodal eliminating the usual Gaussian-based processors. The development of a sequential bootstrap processor for this problem is discussed and shown how it is capable of providing an enhanced signal for eventual detection.

  10. Laboratory Activities

    SciTech Connect (OSTI)

    Brown, Christopher F.; Serne, R. Jeffrey

    2008-01-17

    This chapter summarizes the laboratory activities performed by PNNL’s Vadose Zone Characterization Project in support of the Tank Farm Vadose Zone Program, led by CH2M HILL Hanford Group, Inc. The results of these studies are contained in numerous reports (Lindenmeier et al. 2002; Serne et al. 2002a, 2002b, 2002c, 2002d, 2002e; Lindenmeier et al. 2003; Serne et al. 2004a, 2004b; Brown et al. 2005, 2006a, 2007; Serne et al. 2007) and have generated much of the data reported in Chapter 22 (Geochemistry-Contaminant Movement), Appendix G (Geochemistry-Contaminant Movement), and Cantrell et al. (2007, SST WMA Geochemistry Data Package – in preparation). Sediment samples and characterization results from PNNL’s Vadose Zone Characterization Project are also shared with other science and technology (S&T) research projects, such as those summarized in Chapter 12 (Associated Science Activities).

  11. Detection and treatment of chemical weapons and/or biological pathogens

    DOE Patents [OSTI]

    Mariella Jr., Raymond P.

    2004-09-07

    A system for detection and treatment of chemical weapons and/or biological pathogens uses a detector system, an electrostatic precipitator or scrubber, a circulation system, and a control. The precipitator or scrubber is activated in response to a signal from the detector upon the detection of chemical weapons and/or biological pathogens.

  12. Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels

    DOE Patents [OSTI]

    Mathies, Richard A.; Singhal, Pankaj; Xie, Jin; Glazer, Alexander N.

    2002-01-01

    This invention relates to a microfabricated capillary electrophoresis chip for detecting multiple redox-active labels simultaneously using a matrix coding scheme and to a method of selectively labeling analytes for simultaneous electrochemical detection of multiple label-analyte conjugates after electrophoretic or chromatographic separation.

  13. Attribute and topology based change detection in a constellation of previously detected objects

    DOE Patents [OSTI]

    Paglieroni, David W.; Beer, Reginald N.

    2016-01-19

    A system that applies attribute and topology based change detection to networks of objects that were detected on previous scans of a structure, roadway, or area of interest. The attributes capture properties or characteristics of the previously detected objects, such as location, time of detection, size, elongation, orientation, etc. The topology of the network of previously detected objects is maintained in a constellation database that stores attributes of previously detected objects and implicitly captures the geometrical structure of the network. A change detection system detects change by comparing the attributes and topology of new objects detected on the latest scan to the constellation database of previously detected objects.

  14. Categorical Exclusion Determinations: NNSA-Proliferation Detection |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Proliferation Detection Categorical Exclusion Determinations: NNSA-Proliferation Detection Categorical Exclusion Determinations issued by NNSA-Proliferation Detection. DOCUMENTS AVAILABLE FOR DOWNLOAD September 17, 2010 CX-004080: Categorical Exclusion Determination Fisk University Nonproliferation Grant CX(s) Applied: B3.6 Date: 09/17/2010 Location(s): Tennessee Office(s): NNSA-Proliferation Detection

  15. Detection of Neutrons with Scintillation Counters

    DOE R&D Accomplishments [OSTI]

    Hofstadter, R.

    1948-11-01

    Detection of slow neutrons by: detection of single gamma rays following capture by cadmium or mercury; detection of more than one gamma ray by observing coincidences after capture; detection of heavy charged particles after capture in lithium or baron nuclei; possible use of anthracene for counting fast neutrons investigated briefly.

  16. Noise canceling in-situ detection

    DOE Patents [OSTI]

    Walsh, David O.

    2014-08-26

    Technologies applicable to noise canceling in-situ NMR detection and imaging are disclosed. An example noise canceling in-situ NMR detection apparatus may comprise one or more of a static magnetic field generator, an alternating magnetic field generator, an in-situ NMR detection device, an auxiliary noise detection device, and a computer.

  17. Review of current neutron detection systems for emergency response

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mukhopadhyay, Sanjoy; Maurer, Richard; Guss, Paul; Kruschwitz, Craig

    2014-09-05

    Neutron detectors are utilized in a myriad of applications—from safeguarding special nuclear materials (SNM) to determining lattice spacing in soft materials. The transformational changes taking place in neutron detection and imaging techniques in the last few years are largely being driven by the global shortage of helium-3 (3He). This article reviews the status of neutron sensors used specifically for SNM detection in radiological emergency response. These neutron detectors must be highly efficient, be rugged, have fast electronics to measure neutron multiplicity, and be capable of measuring direction of the neutron sources and possibly image them with high spatial resolution. Neutronmore » detection is an indirect physical process: neutrons react with nuclei in materials to initiate the release of one or more charged particles that produce electric signals that can be processed by the detection system. Therefore, neutron detection requires conversion materials as active elements of the detection system; these materials may include boron-10 (10B), lithium-6 (6Li), and gadollinium-157 (157Gd), to name a few, but the number of materials available for neutron detection is limited. However, in recent years, pulse-shape-discriminating plastic scintillators, scintillators made of helium-4 (4He) under high pressure, pillar and trench semiconductor diodes, and exotic semiconductor neutron detectors made from uranium oxide and other materials have widely expanded the parameter space in neutron detection methodology. In this article we will pay special attention to semiconductor-based neutron sensors. Finally, modern microfabricated nanotubes covered inside with neutron converter materials and with very high aspect ratios for better charge transport will be discussed.« less

  18. Review of current neutron detection systems for emergency response

    SciTech Connect (OSTI)

    Mukhopadhyay, Sanjoy; Maurer, Richard; Guss, Paul; Kruschwitz, Craig

    2014-09-05

    Neutron detectors are utilized in a myriad of applications—from safeguarding special nuclear materials (SNM) to determining lattice spacing in soft materials. The transformational changes taking place in neutron detection and imaging techniques in the last few years are largely being driven by the global shortage of helium-3 (3He). This article reviews the status of neutron sensors used specifically for SNM detection in radiological emergency response. These neutron detectors must be highly efficient, be rugged, have fast electronics to measure neutron multiplicity, and be capable of measuring direction of the neutron sources and possibly image them with high spatial resolution. Neutron detection is an indirect physical process: neutrons react with nuclei in materials to initiate the release of one or more charged particles that produce electric signals that can be processed by the detection system. Therefore, neutron detection requires conversion materials as active elements of the detection system; these materials may include boron-10 (10B), lithium-6 (6Li), and gadollinium-157 (157Gd), to name a few, but the number of materials available for neutron detection is limited. However, in recent years, pulse-shape-discriminating plastic scintillators, scintillators made of helium-4 (4He) under high pressure, pillar and trench semiconductor diodes, and exotic semiconductor neutron detectors made from uranium oxide and other materials have widely expanded the parameter space in neutron detection methodology. In this article we will pay special attention to semiconductor-based neutron sensors. Finally, modern microfabricated nanotubes covered inside with neutron converter materials and with very high aspect ratios for better charge transport will be discussed.

  19. Method for detecting toxic gases

    DOE Patents [OSTI]

    Stetter, Joseph R.; Zaromb, Solomon; Findlay, Jr., Melvin W.

    1991-01-01

    A method capable of detecting low concentrations of a pollutant or other component in air or other gas, utilizing a combination of a heating filament having a catalytic surface of a noble metal for exposure to the gas and producing a derivative chemical product from the component, and an electrochemical sensor responsive to the derivative chemical product for providing a signal indicative of the product. At concentrations in the order of about 1-100 ppm of tetrachloroethylene, neither the heating filament nor the electrochemical sensor is individually capable of sensing the pollutant. In the combination, the heating filament converts the benzyl chloride to one or more derivative chemical products which may be detected by the electrochemical sensor.

  20. Method for detecting toxic gases

    DOE Patents [OSTI]

    Stetter, J.R.; Zaromb, S.; Findlay, M.W. Jr.

    1991-10-08

    A method is disclosed which is capable of detecting low concentrations of a pollutant or other component in air or other gas. This method utilizes a combination of a heating filament having a catalytic surface of a noble metal for exposure to the gas and producing a derivative chemical product from the component. An electrochemical sensor responds to the derivative chemical product for providing a signal indicative of the product. At concentrations in the order of about 1-100 ppm of tetrachloroethylene, neither the heating filament nor the electrochemical sensor is individually capable of sensing the pollutant. In the combination, the heating filament converts the benzyl chloride to one or more derivative chemical products which may be detected by the electrochemical sensor. 6 figures.

  1. Multiplex detection of agricultural pathogens

    SciTech Connect (OSTI)

    Siezak, Thomas R.; Gardner, Shea; Torres, Clinton; Vitalis, Elizabeth; Lenhoff, Raymond J.

    2013-01-15

    Described are kits and methods useful for detection of agricultural pathogens in a sample. Genomic sequence information from agricultural pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay and/or an array assay to successfully identify the presence or absence of pathogens in a sample.

  2. Detection of a concealed object

    DOE Patents [OSTI]

    Keller, Paul E [Richland, WA; Hall, Thomas E [Kennewick, WA; McMakin, Douglas L [Richland, WA

    2010-11-16

    Disclosed are systems, methods, devices, and apparatus to determine if a clothed individual is carrying a suspicious, concealed object. This determination includes establishing data corresponding to an image of the individual through interrogation with electromagnetic radiation in the 200 MHz to 1 THz range. In one form, image data corresponding to intensity of reflected radiation and differential depth of the reflecting surface is received and processed to detect the suspicious, concealed object.

  3. Detection of malicious computer executables

    DOE Patents [OSTI]

    Cai, Dongming M.; Gokhale, Maya

    2009-04-14

    A method of detecting malicious binary executable files is accomplished by inputting a binary executable file; converting the binary executable file to byte hexadecimal text strings; calculating the frequency of each byte pattern in the byte hexadecimal text strings; selecting characteristic byte pattern frequencies as discriminating features; classifying the discriminating features as malicious or benign; labeling the binary executable file as malicious or benign; and outputting the labeled malicious or benign binary executable file.

  4. Multiplex detection of agricultural pathogens

    DOE Patents [OSTI]

    McBride, Mary Teresa; Slezak, Thomas Richard; Messenger, Sharon Lee

    2010-09-14

    Described are kits and methods useful for detection of seven agricultural pathogens (BPSV; BHV; BVD; FMDV; BTV; SVD; and VESV) in a sample. Genomic sequence information from 7 agricultural pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay to successfully identify the presence or absence of pathogens in a sample.

  5. Tritium Detection Methods and Limitations

    Office of Environmental Management (EM)

    Detection Methods and Limitations Tritium Focus Group Meeting, April 2014 Tom Voss, Northern New Mexico DOE-HDBK-1105-2002 RADIOLOGICAL TRAINING FOR TRITIUM FACILITIES U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. DOE-HDBK-1105-2002 Radiological Training for Tritium Facilities U.S. Department of Energy, Radiological Control Programs for Special Tritium Compounds, DOE-STD- draft, Washington, D.C.

  6. Detection of a concealed object

    DOE Patents [OSTI]

    Keller, Paul E. (Richland, WA); Hall, Thomas E. (Kennewick, WA); McMakin, Douglas L. (Richland, WA)

    2008-04-29

    Disclosed are systems, methods, devices, and apparatus to determine if a clothed individual is carrying a suspicious, concealed object. This determination includes establishing data corresponding to an image of the individual through interrogation with electromagnetic radiation in the 200 MHz to 1 THz range. In one form, image data corresponding to intensity of reflected radiation and differential depth of the reflecting surface is received and processed to detect the suspicious, concealed object.

  7. Compensated intruder-detection systems

    DOE Patents [OSTI]

    McNeilly, David R.; Miller, William R.

    1984-01-01

    Intruder-detection systems in which intruder-induced signals are transmitted through a medium also receive spurious signals induced by changes in a climatic condition affecting the medium. To combat this, signals received from the detection medium are converted to a first signal. The system also provides a reference signal proportional to climate-induced changes in the medium. The first signal and the reference signal are combined for generating therefrom an output signal which is insensitive to the climatic changes in the medium. An alarm is energized if the output signal exceeds a preselected value. In one embodiment, an acoustic cable is coupled to a fence to generate a first electrical signal proportional to movements thereof. False alarms resulting from wind-induced movements of the fence (detection medium) are eliminated by providing an anemometer-driven voltage generator to provide a reference voltage proportional to the velocity of wind incident on the fence. An analog divider receives the first electrical signal and the reference signal as its numerator and denominator inputs, respectively, and generates therefrom an output signal which is insensitive to the wind-induced movements in the fence.

  8. Infrared trace element detection system

    DOE Patents [OSTI]

    Bien, F.; Bernstein, L.S.; Matthew, M.W.

    1988-11-15

    An infrared trace element detection system includes an optical cell into which the sample fluid to be examined is introduced and removed. Also introduced into the optical cell is a sample beam of infrared radiation in a first wavelength band which is significantly absorbed by the trace element and a second wavelength band which is not significantly absorbed by the trace element for passage through the optical cell through the sample fluid. The output intensities of the sample beam of radiation are selectively detected in the first and second wavelength bands. The intensities of a reference beam of the radiation are similarly detected in the first and second wavelength bands. The sensed output intensity of the sample beam in one of the first and second wavelength bands is normalized with respect to the other and similarly, the intensity of the reference beam of radiation in one of the first and second wavelength bands is normalized with respect to the other. The normalized sample beam intensity and normalized reference beam intensity are then compared to provide a signal from which the amount of trace element in the sample fluid can be determined. 11 figs.

  9. Anomaly Detection in Dynamic Networks

    SciTech Connect (OSTI)

    Turcotte, Melissa

    2014-10-14

    Anomaly detection in dynamic communication networks has many important security applications. These networks can be extremely large and so detecting any changes in their structure can be computationally challenging; hence, computationally fast, parallelisable methods for monitoring the network are paramount. For this reason the methods presented here use independent node and edge based models to detect locally anomalous substructures within communication networks. As a first stage, the aim is to detect changes in the data streams arising from node or edge communications. Throughout the thesis simple, conjugate Bayesian models for counting processes are used to model these data streams. A second stage of analysis can then be performed on a much reduced subset of the network comprising nodes and edges which have been identified as potentially anomalous in the first stage. The first method assumes communications in a network arise from an inhomogeneous Poisson process with piecewise constant intensity. Anomaly detection is then treated as a changepoint problem on the intensities. The changepoint model is extended to incorporate seasonal behavior inherent in communication networks. This seasonal behavior is also viewed as a changepoint problem acting on a piecewise constant Poisson process. In a static time frame, inference is made on this extended model via a Gibbs sampling strategy. In a sequential time frame, where the data arrive as a stream, a novel, fast Sequential Monte Carlo (SMC) algorithm is introduced to sample from the sequence of posterior distributions of the change points over time. A second method is considered for monitoring communications in a large scale computer network. The usage patterns in these types of networks are very bursty in nature and don’t fit a Poisson process model. For tractable inference, discrete time models are considered, where the data are aggregated into discrete time periods and probability models are fitted to the

  10. Idaho National Laboratory Supervisory Control and Data Acquisition Intrusion Detection System (SCADA IDS)

    SciTech Connect (OSTI)

    Jared Verba; Michael Milvich

    2008-05-01

    Current Intrusion Detection System (IDS) technology is not suited to be widely deployed inside a Supervisory, Control and Data Acquisition (SCADA) environment. Anomaly- and signature-based IDS technologies have developed methods to cover information technology-based networks activity and protocols effectively. However, these IDS technologies do not include the fine protocol granularity required to ensure network security inside an environment with weak protocols lacking authentication and encryption. By implementing a more specific and more intelligent packet inspection mechanism, tailored traffic flow analysis, and unique packet tampering detection, IDS technology developed specifically for SCADA environments can be deployed with confidence in detecting malicious activity.