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Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Mi Tío Atahualpa  

E-Print Network [OSTI]

Mi Tío Atahualpa Carvalho-Neto, Paulode. Mi Tio Atahualpa. México; Ed. Siglo XXI, 1972 Autor decarácter político-social. En Mi Tío Atahualpa, Carvalho-Neto

Cantú, Roberto

1973-01-01T23:59:59.000Z

2

Mi Mente y la Raya  

E-Print Network [OSTI]

Mester, Vo¡. xx. No. 1 (Spring, Mi Mentey Mi mente No Ante A ante encuentra el juicio el la textodesparrama se siente Mi mente Se enfrentan, trastornan Pero

Mester, [No author

1991-01-01T23:59:59.000Z

3

Ne tak jsi mi pskal Kdyzs mi rucku stskal  

E-Print Network [OSTI]

Ne tak Ne tak jsi mi pískal Kdyzs mi rucku stískal A pravils mi svarnás je A traz m peres, mé srdecko dres A pravís mi spatnás je Vybil jsi mn zuby Z mojí slicné huby A pravís mi starás je Vybod jsi mi oci Na lzecku v noci A pravís mi slepás je Not so This is not the song you whistled to me When you

Zapletal, Jindrich

4

Mi Tierra-Mi Mundo Immersive Real/Virtual Watershed Experiences  

E-Print Network [OSTI]

Mi Tierra-Mi Mundo Immersive Real/Virtual Watershed Experiences * SMITHSONIAN LATINO VIRTUAL MUSEUM (proprietary and open source) Games (standalone game quests in Unity 3D- Mi Tierra-Mi Mundo) Interactive Game Website (microsite for Mi Tierra-Mi Mundo) Delete text and place photo here. LVMinteractive.org/3dgames

Mathis, Wayne N.

5

Datum Mi, 21.05 Mi, 23.07 Mi, 07.05 Mi, 25.06 Mi, 16.07 Prfer / Jahr/KW 21/14 30/14 19/14 26/14 29/14  

E-Print Network [OSTI]

Datum Mi, 21.05 Mi, 23.07 Mi, 07.05 Mi, 25.06 Mi, 16.07 Prüfer / Jahr/KW 21/14 30/14 19/14 26/14 29 (TU Graz) 18:00 �bersicht baulicher Komponenten Zenz (TU Graz) 18:00 Mi, 15.10 Mi, 05.11 Mi, 17.12 Mi, 04.02 Mi, 03.12 42/14 45/14 51/14 06/15 49/14 2. Semester Maschinenbauwerkstoffe Mayrhuber (Verbund

6

Datum Mi, 19.03 Mi, 21.05 Mi, 23.07 Mi, 07.05 Mi, 25.06 Mi, 16.07 Prfer / Jahr/KW 12/14 21/14 30/14 19/14 26/14 29/14  

E-Print Network [OSTI]

Datum Mi, 19.03 Mi, 21.05 Mi, 23.07 Mi, 07.05 Mi, 25.06 Mi, 16.07 Prüfer / Jahr/KW 12/14 21/14 30 Komponenten Zenz (TU Graz) 18:00 Mi, 15.10 Mi, 05.11 Mi, 14.01 Mi, 17.12 Mi, 04.02 Mi, 03.12 42/14 45/14 03, Dichtsystem Zenz (TU Graz) 18:00 Mi, 15.04 Mi, 17.06 Mi, 11.03 Mi, 20.05 Mi, 24.06 Mi, 15.07 Mi, 25.03 Mi, 06

7

College of Medicine MI Microbiology and Immunology  

E-Print Network [OSTI]

College of Medicine MI Microbiology and Immunology KEY: # = new course * = course changed = course dropped University of Kentucky 2013-2014 Undergraduate Bulletin 1 MI 494G IMMUNOBIOLOGY. (3,immunogenetics,allergicreactions,tumorimmunologyandtransplantationimmunology.Prereq:BCH401G(maybetaken concurrently) and BIO 208 or BIO 308 or consent of instructor. (Same as BIO 494G.) MI

MacAdam, Keith

8

miRNAs in brain development  

SciTech Connect (OSTI)

MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan, E-mail: johan.jakobsson@med.lu.se

2014-02-01T23:59:59.000Z

9

Ppn. SoL Snow Deplh Observer Vis. Vi;,. Vis. 00 in. 0 in. S5 J5 mi. mi. \\7 mi.  

E-Print Network [OSTI]

. Vi;,. Vis. 00 in. 0 in. S5 J5 mi. mi. \\7 mi. #12;..,- . M I~ · , \\f: ':'0 ll)A.\\I~S· Jb/ Ii I i. $".7~in. 0700 1300 1900 R.H. 24 hr. Mov. Clds. Clds. Clds.Sea L. - ! 0lU/l() .:. flOS-~ '/c. - mi. 30. Vis.Ppn. Sol. Snow Depth Observer a ~Sin. mi. J5 1111. mi.Q.O in. \\/ \\7_____~_____._._!O

Thompson, Anne

10

Los busco y los encuentro en medio de mi alma  

E-Print Network [OSTI]

y los encuentro en medio de mi alma Me buscándote por iré lade Georgia iré donde te donde mi corazón vio tus ojos más

García, Luis Miguel Vicente

1989-01-01T23:59:59.000Z

11

EV Community Readiness projects: Clean Energy Coalition (MI)...  

Broader source: Energy.gov (indexed) [DOE]

Clean Energy Coalition (MI); Clean Fuels Ohio EV Community Readiness projects: Clean Energy Coalition (MI); Clean Fuels Ohio 2013 DOE Hydrogen and Fuel Cells Program and Vehicle...

12

oe oe oe oe oe Mi ye ma lel gvu  

E-Print Network [OSTI]

& & V ? c c c c Soprano Alto Tenor Bass q»¡¶ oe oe oe oe oe Mi ye ma lel gvu oe oe oe oe oe rot yis ra el o oe oe oe oe oe Mi ye ma lel o tan mi tan mi oe oe oe oe oe Mi ye ma lel o yim ne? yim ne tan mi oe oe oe oe oe Mi ye ma lel gvu w ah oe oe oe oe oe Hen be chol dor ya yim ne w rot

Setiawan, Hendra

13

Addendum to NuMI shielding assessment  

SciTech Connect (OSTI)

The original safety assessment and the Safety Envelope for the NuMI beam line corresponds to 400 kW of beam power. The Main Injector is currently capable of and approved for producing 500 kW of beam power2. However, operation of the NuMI beam line at 400 kW of power brings up the possibility of an occasional excursion above 400 kW due to better than usual tuning in one of the machines upstream of the NuMI beam line. An excursion above the DOE approved Safety Envelope will constitute a safety violation. The purpose of this addendum is to evaluate the radiological issues and modifications required to operate the NuMI beam line at 500 kW. This upgrade will allow 400 kW operations with a reasonable safety margin. Configuration of the NuMI beam line, boundaries, safety system and the methodologies used for the calculations are as described in the original NuMI SAD. While most of the calculations presented in the original shielding assessment were based on Monte Carlo simulations, which were based on the design geometries, most of the results presented in this addendum are based on the measurements conducted by the AD ES&H radiation safety group.

Vaziri, Kamran; /Fermilab

2007-10-01T23:59:59.000Z

14

2438 Biochemistry 1993, 32, 2438-2454 Lipid Headgroup and Acyl Chain Composition Modulate the MI-MI1 Equilibrium  

E-Print Network [OSTI]

2438 Biochemistry 1993, 32, 2438-2454 Lipid Headgroup and Acyl Chain Composition Modulate the MI-MI (MI) to metarhodopsin I1 (MII) conformational transition as the trigger for an intracellular enzyme of the lipid headgroups wasvaried. The ratio of MII/MI produced in these recombinants by an actinic flash at 28

Brown, Michael F.

15

miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor  

SciTech Connect (OSTI)

Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

Park, Jong-Kook [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States)] [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States); Henry, Jon C. [Department of Surgery, Ohio State University, Columbus, OH 43210 (United States)] [Department of Surgery, Ohio State University, Columbus, OH 43210 (United States); Jiang, Jinmai [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States)] [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States); Esau, Christine [Regulus Therapeutics, Carlsbad, CA (United States)] [Regulus Therapeutics, Carlsbad, CA (United States); Gusev, Yuriy [Lombardi Cancer Center, Georgetown University, Washington, DC (United States)] [Lombardi Cancer Center, Georgetown University, Washington, DC (United States); Lerner, Megan R. [Veterans Affairs Medical Center, Oklahoma City, OK (United States)] [Veterans Affairs Medical Center, Oklahoma City, OK (United States); Postier, Russell G. [Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States)] [Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Brackett, Daniel J. [Veterans Affairs Medical Center, Oklahoma City, OK (United States)] [Veterans Affairs Medical Center, Oklahoma City, OK (United States); Schmittgen, Thomas D., E-mail: Schmittgen.2@osu.edu [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States)

2011-03-25T23:59:59.000Z

16

HSL HSL MI20 PACKAGE SPECIFICATION HSL 2007  

E-Print Network [OSTI]

HSL HSL MI20 PACKAGE SPECIFICATION HSL 2007 1 SUMMARY Given an nÃ?n sparse matrix A and an n-vector z, HSL MI20 computes the vector x = Mz, where M is an algebraic multigrid (AMG) v allocatable dummy arguments and allocatable components of derived types. Remark: The development of HSL MI20

Silvester, David J.

17

miR-153 and miR-335, Ethanol Sensitive MicroRNAs, Control NSC/NPC Maturation during Fetal Brain Development  

E-Print Network [OSTI]

is increasing through years. Previous research by Sathyan and his colleague has shown that only few miRNAs, miR-9, miR-21, miR-153, and miR-335, were able to mediate ethanol’s teratogenic effects through regulation neural stem/progenitor cell (NSC/NPC). However...

Tsai, Pai Chi

2014-05-05T23:59:59.000Z

18

Mi GmbH | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte GmbH Jump to: navigation,MetalysisMi GmbH Jump to: navigation,

19

,"Sault St Marie, MI Natural Gas Pipeline Exports to Canada ...  

U.S. Energy Information Administration (EIA) Indexed Site

Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description"," Of...

20

,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf...  

U.S. Energy Information Administration (EIA) Indexed Site

Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI...

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

,"Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf...  

U.S. Energy Information Administration (EIA) Indexed Site

Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Marysville, MI...

22

Examen de calcul matriciel Licence MASHS -MI -SPC, semestre 2  

E-Print Network [OSTI]

Examen de calcul matriciel Licence MASHS - MI - SPC, semestre 2 14 juin 2007 Durée de l'épreuve : 3

Lafont, Yves

23

Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats  

E-Print Network [OSTI]

treatment in post- myocardial infarction failing heart rats Christophe ADAMY1,2,9 , Paul MULDER3,4,9 , Lara-MI failing heart rat Key words: chronic heart failure; glutathione; N-acetylcysteine; neutral, we showed that the left ventricle (LV) of human failing heart was depleted in total glutathione by 54

Paris-Sud XI, Université de

24

Electron Cloud induced instabilities in the Fermilab Main Injector (MI) for the High Intensity Neutrino Source (HINS) project  

E-Print Network [OSTI]

Fermilab Main Injector (MI) for the High Intensity Neutrinofor the Fermilab maininjector (MI) show the existence of amitance growth. The Fermilab MI is being considered for an

Sonnad, Kiran G.; Furman, Miguel A.; Vay, Jean-Luc; Venturini, Marco; Celata, Christine; Grote, David

2008-01-01T23:59:59.000Z

25

Electron Cloud induced instabilities in the Fermilab Main Injector (MI) for the High Intensity Neutrino Source (HINS) project  

E-Print Network [OSTI]

induced instabilities in the Fermilab Main Injector (MI) forrings. Results for the Fermilab maininjector (MI) show theem- mitance growth. The Fermilab MI is being considered for

Sonnad, Kiran G.; Furman, Miguel A.; Vay, Jean-Luc; Venturini, Marco; Celata, Christine; Grote, David

2008-01-01T23:59:59.000Z

26

TOOL KIT CHECKLIST 12DOM_MI058  

E-Print Network [OSTI]

TOOL KIT CHECKLIST 12DOM_MI058 TOOLS fOr DIY Considerthetypesofprojectsyouwillbeundertaking,secondhandisfineifthey'reingoodcondition. Anycuttingsurfacesmustberazorsharpandbespecifictothematerialtobecut. Tools--especiallypowertools--canbeverydangerous. "Reality,wastingmoneyandlettingfrustrationandfailuremakeyourprojectsunpleasant (andunsuccessful)andworsestill,putyouoffanymoreDIY. #12;TOOL KIT CHECKLIST 12DOM_MI058 BASIC TOOL KITS MAY INCLUDE

Peters, Richard

27

"Orgulloso de mi Caserío y de Quien Soy": Race, Place, and Space in Puerto Rican Reggaetón  

E-Print Network [OSTI]

Samponaro, Philip. ""Oye mi canto" ("Listen to My Song"):Báez, Jillian M. ""En mi imperio": Competing Discourses ofOrgulloso de mi Caserío y de Quien Soy”: Race, Place, and

Rivera, Petra Raquel

2010-01-01T23:59:59.000Z

28

8232 Federal Register / Vol. 74, No. 35 / Tuesday, February 24, 2009 / Notices March 18, 6:30 p.m ....................... Rogers City, MI ............................. Presque Isle District Library, 181 East Erie Street, Rogers City, MI  

E-Print Network [OSTI]

.m ....................... Rogers City, MI ............................. Presque Isle District Library, 181 East Erie Street, Rogers City, MI 49779. March 19, 6:30 p.m ....................... Harrisville, MI ............................... Harrisville Courthouse, 106 North 5th Street, Harrisville, MI 48740. March 20, 2 p

29

The Role of miR-143 and miR-145 in the Invasion of Glioblastoma  

E-Print Network [OSTI]

IM3 U87 and U87 IM3 cells were transfected with either FITC-labeled anti-miR-143, anti- miR-145, or a control LNA knockdown probe which binds nothing in the cell (Exiqon, Vedbaek, Denmark) at final concentration of 50nM using Lipofectamine 2000...

Ronck, Matthew K 1984-

2012-07-11T23:59:59.000Z

30

I. El duelo de Requiem para (mi?) infancia RIO-plat-ENSE  

E-Print Network [OSTI]

El duelo I. de Réquiem para (mi? ) infância RIO-plat-ENSE "El duelo (de Réquiem para (mi? ) infancia RIO-plat-ENSE>

Pellarolo, Silvia

1989-01-01T23:59:59.000Z

31

,"St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf...  

U.S. Energy Information Administration (EIA) Indexed Site

Exports to Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI...

32

,"St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf...  

U.S. Energy Information Administration (EIA) Indexed Site

Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI...

33

Mi Abuelo Camina La Tierra Con Nobleza y Paz  

E-Print Network [OSTI]

con nobleza y paz Se me fue mi Abuelo pero aun así me siguevalor valor para amarme a mí misma © 2014 Elizabeth GonzálezCárdenas valor para protegerme a mí misma valor para cambiar

González Cárdenas, Elizabeth

2014-01-01T23:59:59.000Z

34

The Office of Minority Economic Impact (MI) was established in...  

Office of Environmental Management (EM)

in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95- 619), dated November 9, 1978. The following is MI's...

35

MicroRNAs in early embryonic development : dissecting the role of miR-290 through miR-295 in the mouse  

E-Print Network [OSTI]

MicroRNAs mediate developmental regulation of gene expression via translational repression of target mRNAs. Targeted deletion of the miRNA biogenesis machinery in the mouse has demonstrated essential roles for miRNAs during ...

Dennis, Lucas M

2008-01-01T23:59:59.000Z

36

Posizione Matricola Corso di Laurea Magistrale Sede isc. Sede alt. Voto laurea Data nascita 1 764721 I-INGEGNERIA MATEMATICA MI 110 05/11/1988  

E-Print Network [OSTI]

764721 I-INGEGNERIA MATEMATICA MI 110 05/11/1988 2 771099 I-INGEGNERIA BIOMEDICA MI 110 19/10/1987 3 783806 I-INGEGNERIA BIOMEDICA MI MI 110 19/05/1989 4 783463 I-INGEGNERIA BIOMEDICA MI MI 110 19/05/1989 5 769961 I-INGEGNERIA BIOMEDICA MI MI 110 10/01/1989 6 764825 I-INGEGNERIA MATEMATICA MI LC 110 22

37

Supplementary Table1. TE-derived miRNAs. ath-MIR414 MI0001425 chr1:25141119-25141226(-) ATCopia24I  

E-Print Network [OSTI]

Supplementary Table1. TE-derived miRNAs. Namea Accnb Coordsc TEd Overlape ath-MIR414 MI0001425 chr1:25141119-25141226(-) ATCopia24I (LTR/Copia) 57.41 ath-MIR855 MI0005411 chr2:4681509-4681780(+) Athila4B_LTR (LTR/Gypsy) 100.00 ath-MIR416 MI0001427 chr2:7015602-7015681(+) Vandal1 (DNA/MuDR) 100.00 ath-MIR405a MI0001074 chr2

Jordan, King

38

The NuMI Neutrino Beam at Fermilab  

E-Print Network [OSTI]

The Neutrinos at the Main Injector (NuMI) facility at Fermilab is due to begin operations in late 2004. NuMI will deliver an intense muon neutrino beam of variable energy 2-20 GeV directed into the Earth at 58 mrad for short (~1 km) and long (~700-900 km) baseline experiments. Several aspects of the design are reviewed, as are potential upgrade requirements to the facility in the event a Proton Driver is built at Fermilab to enhance the neutrino flux.

Sacha E. Kopp

2004-12-18T23:59:59.000Z

39

miRNA-205 affects infiltration and metastasis of breast cancer  

SciTech Connect (OSTI)

Highlights: •We detected expression of miR-205 in breast cancer cell lines and tissue samples. •We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. •We suggest the lower expression of miR-205 play a role in breast cancer onset. •These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

Wang, Zhouquan [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061 (China) [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061 (China); Department of Tumor, SenGong Hospital of Shaanxi, Xi’an 710300 (China); Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061 (China)] [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061 (China); Ren, Hong, E-mail: renhongs2000@yahoo.com.cn [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061 (China)] [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061 (China)

2013-11-08T23:59:59.000Z

40

Just the Tip of the Iceberg: The Truncation of Mexican American Identity in My Family/Mi Familia  

E-Print Network [OSTI]

Huaco-Nuzman, Carmen. "Mi Familia/My Family." Review. AztlánAmerica. lowa City: Familia/Mi Familia. Dir. Gregory Nava.Saga Traces 'My My Family/Mi Familia. National Catholic

Serrato, Phillip

2004-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Los Angeles of My Broken Heart: Pocha Mobility in México de mi corazón and Del otro lado del puente  

E-Print Network [OSTI]

Emilio García. “México de mi corazón. ” Historia documental372-373. Print. Films México de mi corazón (Dos mexicanas enPocha Mobility in México de mi corazón and Del otro lado del

Parades, Veronica

2012-01-01T23:59:59.000Z

42

Politically Escapist… or Engaged? History and Subversion in Leonardo Padura’s La novela de mi vida  

E-Print Network [OSTI]

y ficción en La novela de mi vida: La historia como versiónPadura Fuentes: La novela de mi vida. Academic Detecting andin Leonardo Padura’s La novela de mi vida RUDYARD J. ALCOCER

Alcocer, Rudyard J.

2014-01-01T23:59:59.000Z

43

E-Print Network 3.0 - ann arbor mi Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mi Search Powered by Explorit Topic List Advanced Search Sample search results for: ann arbor mi Page: << < 1 2 3 4 5 > >> 1 2011 University of Michigan Medical School Residency...

44

May 2 6, 2011 University of Michigan, Ann Arbor, MI  

E-Print Network [OSTI]

May 2 ­ 6, 2011 University of Michigan, Ann Arbor, MI Young Researchers and Grad Students of Michigan, Chair, Craig Evans ­ Univ of California, Berkeley, Tai-Ping Liu ­ Stanford, Craig Tracy ­ Univ, Institute of Mathematics and its Applications-University of Minnesota, Department of Mathematics-University

Temple, Blake

45

Comparative Genomic Discovery of miRNAs Grad et al.  

E-Print Network [OSTI]

Comparative Genomic Discovery of miRNAs Grad et al. Computational and Experimental Identification throughout the adult life cycle (Feinbaum and Ambros, 1999; Lee et al., 1993; Reinhart et al., 2000 al., 1993; Wightman et al., 1993; Reinhart et al., 2000; Slack et al., 2000). Both lin-4 and let-7

Church, George M.

46

Physics Potential of the Fermilab NuMI beamline  

E-Print Network [OSTI]

We explore the physics potential of the NuMI beamline with a detector located 10 km off-axis at a distant site (810 km). We study the sensitivity to $\\sin^2 2 \\theta_{13}$ and to the CP-violating parameter $\\sin \\delta$ as well as the determination of the neutrino mass hierarchy by exploiting the $\

Olga Mena; Stephen Parke

2005-07-25T23:59:59.000Z

47

Event Rates for Off Axis NuMI Experiments  

E-Print Network [OSTI]

Neutrino interaction rates for experiments placed off axis in the NuMI beam are calculated. Primary proton beam energy is 120 GeV and four locations at 810 km from target and 6, 12, 30 and 40 km off axis are considered. This report is part of the Joint FNAL/BNL Future Long Baseline Neutrino Oscillation Experiment Study.

B. Viren

2006-08-25T23:59:59.000Z

48

Validation of MCNPX-PoliMi Fission Models  

SciTech Connect (OSTI)

We present new results on the measurement of correlated, outgoing neutrons from spontaneous fission events in a Cf-252 source. 16 EJ-309 liquid scintillation detectors are used to measure neutron-neutron correlations for various detector angles. Anisotropy in neutron emission is observed. The results are compared to MCNPX-PoliMi simulations and good agreement is observed.

S. A. Pozzi; S. D. Clarke; W. Walsh; E. C. Miller; J. Dolan; M. Flaska; B. M. Wieger; A. Enqvist; E. Padovani; J. K. Mattingly; D. L. Chichester; P. Peerani

2012-10-01T23:59:59.000Z

49

MCNPX-PoliMi for Nuclear Nonproliferation Applications  

SciTech Connect (OSTI)

In the past few years, efforts to develop new measurement systems to support nuclear nonproliferation and homeland security have increased substantially. Monte Carlo radiation transport is one of the simulation methods of choice for the analysis of data from existing systems and for the design of new measurement systems; it allows for accurate description of geometries, detailed modeling of particle-nucleus interactions, and event-by-event detection analysis. This paper describes the use of the Monte Carlo code MCNPX-PoliMi for nuclear-nonproliferation applications, with particular emphasis on the simulation of spontaneous and neutron-induced nuclear fission. In fact, of all possible neutron-nucleus interactions, neutron-induced fission is the most defining characteristic of special nuclear material (such as U-235 and Pu-239), which is the material of interest in nuclear-nonproliferation applications. The MCNP-PoliMi code was originally released from the Radiation Safety Shielding Center (RSSIC) at Oak Ridge National Laboratory in 2003 [1]; the MCNPX-PoliMi code contains many enhancements and is based on MCNPX ver. 2.7.0. MCNPX-PoliMi ver. 2.0 was released through RSICC in 2012 as a patch to MCNPX ver. 2.7.0 and as an executable [2].

S. A. Pozzi; S. D. Clarke; W. Walsh; E. C. Miller; J. Dolan; M. Flaska; B. M. Wieger; A. Enqvist; E. Padovani; J. K. Mattingly; D. L. Chichester; P. Peerani

2012-12-01T23:59:59.000Z

50

Discovery of miRNA-regulated processes in mammalian development  

E-Print Network [OSTI]

The genomes of plants and animals encode hundreds of non-coding ~22nt RNAs termed "microRNAs" (miRNAs). These RNAs guide the sequence-specific inhibition of translation and destabilization of mRNA targets through short ...

Young, Amanda Garfinkel

2010-01-01T23:59:59.000Z

51

NEC Introduces New miSEAT TSS Technology Collaboration  

E-Print Network [OSTI]

NEC Introduces New miSEAT TSS Technology Collaboration Social aspects keep people collaborative way. All of the touch technology is completely embedded in the surface featuring a full standard #12;Benefits: CLEAN UP - Much more easily cleaned than standard keyboard/mouse setups, germ free

Goldstein, Seth Copen

52

Albert-Ludwigs-Universitt Freiburg 3 Mi Tag der Deutschen Einheit  

E-Print Network [OSTI]

Albert-Ludwigs-Universität Freiburg Oktober 1 Mo 2 Di 3 Mi Tag der Deutschen Einheit 4 Do 5 Fr 6 Sa 7 So 8 Mo 9 Di 10 Mi 11 Do 12 Fr 13 Sa 14 So 15 Mo 16 Di 17 Mi 18 Do 19 Fr Erstsemesternachmittag 20 Sa 21 So 22 Mo Semesterbeginn WiSe 12/13 23 Di 24 Mi Eröffnung Akademisches Jahr 25 Do 26 Fr 27 Sa 28

Schindelhauer, Christian

53

1 Di Neujahr 1 Fr 1 Fr 1 Mo Ostermontag 2 Mi 2 Sa 2 Sa 2 Di  

E-Print Network [OSTI]

1 Di Neujahr 1 Fr 1 Fr 1 Mo Ostermontag 2 Mi 2 Sa 2 Sa 2 Di 3 Do 3 So 3 So 3 Mi 4 Fr 4 Mo 4 Mo 4 Do 5 Sa 5 Di 5 Di 5 Fr 6 So 6 Mi 6 Mi 6 Sa 7 Mo 7 Do 7 Do 7 So 8 Di 8 Fr 8 Fr 8 Mo 9 Mi 9 Sa 9 Sa 9 Di 10 Do 10 So 10 So 10 Mi 11 Fr 11 Mo 11 Mo 11 Do 12 Sa 12 Di 12 Di 12 Fr 13 So 13 Mi 13 Mi Power

Grübel, Rudolf

54

Hematite spherules at Meridiani: Results from MI, Mini-TES, W. M. Calvin,1  

E-Print Network [OSTI]

Hematite spherules at Meridiani: Results from MI, Mini-TES, and Pancam W. M. Calvin,1 J. D on observations of hematite-bearing spherules at Meridiani Planum made using the Microscopic Imager (MI), Mini seen in MI, both Pancam and Mini-TES indices are highly variable based on the local surface

Glotch, Timothy D.

55

M2MI Service Discovery Middleware Framework Hans-Peter Bischof, Joel Varela Donado  

E-Print Network [OSTI]

M2MI Service Discovery Middleware Framework Hans-Peter Bischof, Joel Varela Donado Rochester.rit.edu Abstract. The Many-to-Many-Invocation (M2MI) Service Discovery Middleware Framework provides an API for publishing, providing, and using services in a serverless ad hoc network of devices imple- menting the M2MI

Bischof, Hans-Peter

56

Mi'kmaq Fisheries in Atlantic Canada: Traditions, Legal Decisions and Community Management  

E-Print Network [OSTI]

1 Mi'kmaq Fisheries in Atlantic Canada: Traditions, Legal Decisions and Community Management Chris Sciences, Amsterdam, The Netherlands Abstract Historically, the Mi'kmaq, the indigenous people of Atlantic relationships and government policies. Today, recent court decisions upholding Mi'kmaq rights to the Atlantic

Charles, Anthony

57

UGA ID Number Last Name First MI Academic Term THE UNIVERSITY OF GEORGIA  

E-Print Network [OSTI]

UGA ID Number Last Name First MI Academic Term THE UNIVERSITY OF GEORGIA APPLICATION TO MAKE LATE's Office UGA ID Number Last Name First MI Academic Term THE UNIVERSITY OF GEORGIA APPLICATION TO MAKE LATE's Office UGA ID Number Last Name First MI Academic Term THE UNIVERSITY OF GEORGIA APPLICATION TO MAKE LATE

Arnold, Jonathan

58

Lineare Algebra I (lehramtsbezogen) https://www.mi.fu-berlin.de/kvv/course.htm?cid=10310  

E-Print Network [OSTI]

Lineare Algebra I (lehramtsbezogen) https://www.mi.fu-berlin.de/kvv/course.htm?cid=10310 -- kein@math.fu-berlin.de http://page.mi.fu-berlin.de/gmziegler/ FU Berlin, Winter 2011/2012 0. Lineare Geometrie des n¨uhrung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Mi, 19. Oktober 2. Feststellungstest

Ziegler, Günter M.

59

RATS VERSUS PEOPLE Rats equal twice  

E-Print Network [OSTI]

from rats to man and to other animals. Amebiasis, infectious jaun- dice, Salmonella food poison- ing, and tapeworm infections are spread by rats. The germs are transmitted to man by polluted_food and water. Rat. Rats will gnaw through almost anything in their path to obtain food. Hard substances ~ like concrete

60

MI 625 -Processos Estocasticos Nancy Lopes Garcia, Sala 209 -IMECC  

E-Print Network [OSTI]

MI 625 - Processos Estoc´asticos Nancy Lopes Garcia, Sala 209 - IMECC nancy@ime.unicamp.br, www´etrica para Processos de Poisson · MCMC e simula¸c~ao perfeita 1 #12;Processos Estoc´asticos Infer^encia: Seja´es de um Modelo Log´istico Regressivo, cujas vari´aveis regressoras dependem do tempo anterior, por

Lopes Garcia, Nancy

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Posizione Matricola Corso di Laurea Magistrale Sede isc. Sede alt. Voto laurea Data nascita 1 765363 I-INGEGNERIA NUCLEARE MI BV 110 05/07/1988  

E-Print Network [OSTI]

765363 I-INGEGNERIA NUCLEARE MI BV 110 05/07/1988 2 766599 I-INGEGNERIA NUCLEARE MI 110 21/03/1988 3 764813 I-INGEGNERIA ELETTRICA MI 110 29/04/1987 4 765411 I-INGEGNERIA CHIMICA MI 110 23/05/1988 5 781546 NANOTECHNOLOGY MI 110 19/08/1989 6 778979 NANOTECHNOLOGY MI 110 21/05/1990 7 764495 I-INGEGNERIA NUCLEARE MI 110

62

AGRADECIMIENTOS Quisiera agradecer a mi director de tesis Jos M Rodrguez Ibabe la  

E-Print Network [OSTI]

AGRADECIMIENTOS Quisiera agradecer a mi director de tesis José Mª Rodríguez Ibabe la disposición y tener la cabeza sobre los hombros cuando la mía orbitaba, y a mi familia por estar siempre ahí. Quisiera dedicar esta Tesis a la memoria de Javier Urcola y a la de mi bisabuelo Saturio de Andrés. #12;vi ESKERRAK

Cambridge, University of

63

Stress-MI and domain studies in Co-based nanocrystalline ribbons Sandhya Dwevedi a  

E-Print Network [OSTI]

Stress-MI and domain studies in Co-based nanocrystalline ribbons Sandhya Dwevedi a , G on the magnetoimpedance (MI) effect in melt-spun (Co1�xFex)89Zr7B4 [x¼0, 0.025, 0.05] and (Co0.88Fe0.12)78.4Nb2.6Si9B9Al in large MI. Magnetic domains were investigated in the ribbons through magnetic force microscopy. & 2011

McHenry, Michael E.

64

MHK Technologies/Mi2 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's Heat JumpIncMAKGalway Bay IE <AirWECHelix <IWAVEProfileMi2 < MHK

65

DOE - Office of Legacy Management -- Adrian - MI 01  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou are here Home » Sites » SitesNew MexicoAdrian - MI

66

2012 NIST Precision Measurement Grants Georg Raithel, University of Michigan, Ann Arbor, MI  

E-Print Network [OSTI]

2012 NIST Precision Measurement Grants Georg Raithel, University of Michigan, Ann Arbor, MI to the transition frequencies. Thomas Stace, University of Queensland, Brisbane, Queensland, Australia Thermometry

Magee, Joseph W.

67

Emploi du temps Licence de Mathmatiques semestre 6 MA= parcours maths approfondies M= parcours maths MI= parcours math-info ( groupe C en LI2)  

E-Print Network [OSTI]

M= parcours maths MI= parcours math-info ( groupe C en LI2) 08h00-09h30 09h45-11h15 11h30-13h00 13h15-14h45 15h00-16h30 16h45-18h15 lundi MA MA M M MI MI mardi MA Anglais MA M TD Histoire des Maths M 3.2 M MI Anglais MI mercredi MA TD Variable Complexe M 3.2 MA M M MI MI jeudi MA MA M M MI MI

Berger, Clemens

68

Posizione Matricola Corso di Laurea Magistrale Sede isc. Sede alt. Voto laurea Data nascita 1 782252 A-ARCHITETTURA MI BV 110 07/05/1989  

E-Print Network [OSTI]

782252 A-ARCHITETTURA MI BV 110 07/05/1989 2 766298 A-PIANIFICAZIONE URBANA E POLITICHE TERRITORIALI MI BV 110 20/04/1989 3 770229 A-PIANIFICAZIONE URBANA E POLITICHE TERRITORIALI MI 110 27/06/1988 4 767317 A-ARCHITETTURA MI 110 13/06/1988 5 765987 A-PIANIFICAZIONE URBANA E POLITICHE TERRITORIALI MI 110

69

Kandidatexjobb inom fysik Bjrn Cederstrm, bjorn@mi.physics.kth.se  

E-Print Network [OSTI]

Kandidatexjobb inom fysik VT 2014 Björn Cederström, bjorn@mi.physics.kth.se (avgående kontaktpersonGoLite project #12;Tack! Mer information: http://www.mi.physics.kth.se/web/teaching_kand_exjobb.htm 2013-09-25 12

Haviland, David

70

Abiotic Stress-Associated miRNAs: Detection and Functional Analysis  

E-Print Network [OSTI]

RNAs, accelerating their degradation (6). Many functional studies have demonstrated that plant miR- NAs playRNAs, which is thought to protect them against degradation [(4) and Chapter 10]. The effect of these mutants report that miRNAs are regulated in response to cold, drought, salt, UV-B radiation, phosphate or sulfate

Green, Pamela

71

Using SeDuMi 1.02, a MATLAB toolbox for optimization over symmetric cones  

E-Print Network [OSTI]

SeDuMi is an add-on for MATLAB, that lets you solve optimization problems with linear, quadratic and semidefiniteness constraints. It is possible to have complex valued data and variables in SeDuMi. Moreover, large scale optimization problems are solved efficiently, by exploiting sparsity. This paper describes how to work with this toolbox.

Jos F. Sturm

1998-01-01T23:59:59.000Z

72

Ecloud Build-Up Simulations for the FNAL MI for a Mixed Fill Pattern: Dependence on Peak SEY and Pulse Intensity During the Ramp  

E-Print Network [OSTI]

3] I. Kourbanis, "e-Clotid MI Measurements", 26 Aug. 2007. [Up Simulations for the FNAL MI for a Mixed Fill Pattern:the F N A L Main Injector (MI) for a beam fill pattern made

Furman, M. A.

2011-01-01T23:59:59.000Z

73

MONITORING AND HABITAT ANALYSIS FOR WOLVES IN UPPER MARCEL J. POTVIN,1 School of Forest Resources and Environmental Science Michigan Technological University, Houghton, MI  

E-Print Network [OSTI]

Resources and Environmental Science Michigan Technological University, Houghton, MI 49931, USA THOMAS D. DRUMMER, Department of Mathematical Sciences, Michigan Technological University, Houghton, MI 49931, USA University, Houghton, MI 49931, USA DEAN E. BEYER, JR., Michigan Department of Natural Resources, Marquette

74

Mobility of Tritium in Engineered and Earth Materials at the NuMI Facility, Fermilab: Progress report for work performed between June 13 and September 30, 2006  

E-Print Network [OSTI]

for the NuMI project, FERMILAB-TM-2009 and NuMI-B-279, Fermito NuMI beam tunnels, FERMILAB-TM-2083, Fermi Nationalprotection radiation safety, Fermilab report, July 2001.

2006-01-01T23:59:59.000Z

75

Posizione Matricola Corso di Laurea Magistrale Sede isc. Sede alt. Voto laurea Data nascita 1 781330 I-GESTIONE DEL COSTRUITO MI 110 11/08/1988  

E-Print Network [OSTI]

781330 I-GESTIONE DEL COSTRUITO MI 110 11/08/1988 2 783933 I-GESTIONE DEL COSTRUITO MI BV 110 03/09/1987 3 766434 I-INGEGNERIA DEI SISTEMI EDILIZI MI 110 30/08/1988 4 761490 I-INGEGNERIA DEI SISTEMI EDILIZI MI 108 17/08/1989 5 776698 I-GESTIONE DEL COSTRUITO MI MI 106 02/05/1989 6 784798 I-INGEGNERIA DEI

76

Posizione Matricola Corso di Luarea magistrale Sede isc. Sede alt. Voto laurea Data nascita 1 783525 I-INGEGNERIA INFORMATICA MI 110 10/04/1989  

E-Print Network [OSTI]

783525 I-INGEGNERIA INFORMATICA MI 110 10/04/1989 2 766724 I-INGEGNERIA ELETTRONICA MI 110 11/01/1989 3 752109 I-INGEGNERIA INFORMATICA MI 110 03/12/1984 4 783081 I-INGEGNERIA INFORMATICA MI BV 110 09/03/1989 5 783397 I-INGEGNERIA DELLE TELECOMUNICAZIONI MI 110 16/02/1988 6 750317 I-INGEGNERIA INFORMATICA MI

77

Posizione Matricola Corso di Laurea Magistrale Sede isc. Sede alt. Voto laurea Data nascita 1 783078 I-INGEGNERIA CIVILE MI CO 110 26/09/1989  

E-Print Network [OSTI]

783078 I-INGEGNERIA CIVILE MI CO 110 26/09/1989 2 783301 I-INGEGNERIA CIVILE MI 110 31/10/1989 3 767166 I-INGEGNERIA PER L'AMBIENTE E IL TERRITORIO MI 110 06/08/1988 4 784194 I-INGEGNERIA PER L'AMBIENTE E IL TERRITORIO MI 110 28/04/1989 5 783920 I-INGEGNERIA CIVILE MI MI 110 31/12/1989 6 782721 I-INGEGNERIA PER L

78

PIANO DI RIQUALIFICAZIONE AMBIENTALE E PAESAGGISTICA DEL TERMOVALORIZZATORE DI DESIO TERMOVALORIZZATORE DI DESIO (MI) BRIANZA ENERGIA E AMBIENTE SPA  

E-Print Network [OSTI]

TERMOVALORIZZATORE DI DESIO (MI) ­ BRIANZA ENERGIA E AMBIENTE SPA Impianto di costruito negli anni '70 per lo

Columbia University

79

2005 Borchardt Conference: A Seminar on Advances in Water and Wastewater Treatment February 23-25, Ann Arbor, MI  

E-Print Network [OSTI]

-25, Ann Arbor, MI Conference Proceedings 1 Membrane Biofilm Reactors for Water and Wastewater Treatment and Wastewater Treatment February 23-25, Ann Arbor, MI Conference Proceedings 2 (sparging) to replenish oxygen: A Seminar on Advances in Water and Wastewater Treatment February 23-25, Ann Arbor, MI Conference Proceedings

Nerenberg, Robert

80

LBL RUNAROUND RESULTS 3.00 km (1.86 mi) September 22, 1995 Dummy first body page  

E-Print Network [OSTI]

LBL RUNAROUND RESULTS 3.00 km (1.86 mi) September 22, 1995 page 0 Dummy first body page #12;LBL RUNAROUND RESULTS 3.00 km (1.86 mi) September 22, 1995 page 1 Place Time Name Group Group Place 1 9:52.4 Ken:59.7 Derek DeBusschere mi

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

LBL RUNAROUND 3.00km (1.865mi) September 13, 1985 page 1 Place Time Name Group Group  

E-Print Network [OSTI]

LBL RUNAROUND 3.00km (1.865mi) September 13, 1985 page 1 Place Time Name Group Group Place 1 10 course record #12;LBL RUNAROUND 3.00km (1.865mi) September 13, 1985 page 2 Place Time Name Group Group-49 19 100 14:03.5 Joshua W. Burton mi) September 13, 1985 page 3

82

LBL RUNAROUND 3.00 km (1.865 mi) September 19, 1986 page 1 Place Time Name Group Group  

E-Print Network [OSTI]

LBL RUNAROUND 3.00 km (1.865 mi) September 19, 1986 page 1 Place Time Name Group Group Place 1 10 12:53.1 Alan Comnes mi) September 19, 1986 page 2.00 km (1.865 mi) September 19, 1986 page 3 Place Time Name Group Group Place 109 14:30.9 Lutgard

83

Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres  

E-Print Network [OSTI]

(5):745-752. 9. Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, Mosk- ovits N, Bentwich Z, Oren M: Transcriptional activation of miR- 34a contributes to p53-mediated apoptosis. Mol Cell 2007, 26(5):731-743. 10. Bommer GT, Gerin I, Feng Y... is consistent with the observed ability of miR-34 to downregulate a program of genes promoting cell cycle progression [12]. miR-34a has been reported to be involved in p53-mediated apoptosis in colon cancer and pancreatic cancer [8,9]. Tazawa et al. provided...

Ji, Qing; Hao, Xinbao; Meng, Yang; Zhang, Min; DeSano, Jeffrey; Fan, Daiming; Xu, Liang

2008-09-21T23:59:59.000Z

84

Solar Flare Measurements with STIX and MiSolFA  

E-Print Network [OSTI]

Solar flares are the most powerful events in the solar system and the brightest sources of X-rays, often associated with emission of particles reaching the Earth and causing geomagnetic storms, giving problems to communication, airplanes and even black-outs. X-rays emitted by accelerated electrons are the most direct probe of solar flare phenomena. The Micro Solar-Flare Apparatus (MiSolFA) is a proposed compact X-ray detector which will address the two biggest issues in solar flare modeling. Dynamic range limitations prevent simultaneous spectroscopy with a single instrument of all X-ray emitting regions of a flare. In addition, most X-ray observations so far are inconsistent with the high anisotropy predicted by the models usually adopted for solar flares. Operated at the same time as the STIX instrument of the ESA Solar Orbiter mission, at the next solar maximum (2020), they will have the unique opportunity to look at the same flare from two different directions: Solar Orbiter gets very close to the Sun wit...

Casadei, Diego

2014-01-01T23:59:59.000Z

85

Modulation of Ago-miRNA regulatory networks by cis-sequence elements and target competition  

E-Print Network [OSTI]

regulators of gene expression in a wide range of organisms and biological processes. Each miRNA guides Argonaute (Ago) protein complexes to target and repress hundreds of genes in a sequence-dependent manner. To identify ...

Bosson, Andrew D. (Andrew David)

2014-01-01T23:59:59.000Z

86

User's Guide for SeDuMi Interface 1.01: Solving LMI problems with ...  

E-Print Network [OSTI]

Nov 2, 2001 ... particular, a major di culty is that control problems are formulated ... these potentialities will be integrated to SeDuMi Interface in the future, depending on ...... improve this document and make some publicity for your results.

2001-11-02T23:59:59.000Z

87

miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells  

SciTech Connect (OSTI)

Highlights: •miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. •miR-196a expression elevated proliferation and migration of cervical cancer cells. •miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. •NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. •NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 2–3 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of miR-196a in cervical carcinogenesis and suggested a potential use of miR-196a for clinical diagnosis and as a therapeutic target.

Zhang, Jie [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China); Zheng, Fangxia [Department of Radiotherapy, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Radiotherapy, Liaocheng People’s Hospital, Liaocheng 252000 (China); Yu, Gang [Department for Disease Control, Tumor Hospital of Liaocheng, Liaocheng 252000 (China)] [Department for Disease Control, Tumor Hospital of Liaocheng, Liaocheng 252000 (China); Yin, Yanhua, E-mail: yinyanhuablk@163.com [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China); Lu, Qingyang [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)

2013-11-01T23:59:59.000Z

88

Mi2b Is Required for c-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in b-YAC Transgenic Mice  

E-Print Network [OSTI]

- globin expression during adult definitive erythropoiesis. Results Expression of c-globin in Mi2b conditional knockout b- YAC mice The NuRD complex is composed of the ATPase Mi2, MTA-1, MTA-2, p66, RbAp46 (RBBP7), RbAp48 (RBBP4), MBD3 and the histone... (Figure 2N), although the Mi2b conditional knockout mice showed fewer strong HbF-positive cells. Mature RBCs are enucleated, making it difficult to demonstrate that the nuclear-localized Mi2b protein is reduced in these cells. To further demonstrate...

Costa, Flavia C.; Fedosyuk, Halyna; Chazelle, Allen M.; Neades, Renee Y.; Peterson, Kenneth R.

2012-12-20T23:59:59.000Z

89

LBL RUNAROUND RESULTS 3.00 km (1.86 mi) October 11, 1996 Dummy first body page  

E-Print Network [OSTI]

LBL RUNAROUND RESULTS 3.00 km (1.86 mi) October 11, 1996 page 0 Dummy first body page #12;LBL RUNAROUND RESULTS 3.00 km (1.86 mi) October 11, 1996 page 1 Place Time Name Group Group Place 1 9:35.6 Place Time Name Group Group Place #12;LBL RUNAROUND RESULTS 3.00 km (1.86 mi) October 11, 1996 page 2

90

miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4  

SciTech Connect (OSTI)

Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3?UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.

Chen, Liang [Neurosurgery Institute, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Zhujiang Hospital of Southern Medical University, Guangzhou 510282 (China) [Neurosurgery Institute, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Zhujiang Hospital of Southern Medical University, Guangzhou 510282 (China); Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 (China); Tang, Yanping [Neurosurgery Institute, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Zhujiang Hospital of Southern Medical University, Guangzhou 510282 (China)] [Neurosurgery Institute, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Zhujiang Hospital of Southern Medical University, Guangzhou 510282 (China); Wang, Jian [Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 (China)] [Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 (China); Yan, Zhongjie [Affiliated Bayi Brain Hospital, The Military General Hospital of Beijing PLA,The Bayi Clinical Medical Institute of Southern Medical University, Beijing 100700 (China)] [Affiliated Bayi Brain Hospital, The Military General Hospital of Beijing PLA,The Bayi Clinical Medical Institute of Southern Medical University, Beijing 100700 (China); Xu, Ruxiang, E-mail: RuxiangXu@yahoo.com [Affiliated Bayi Brain Hospital, The Military General Hospital of Beijing PLA,The Bayi Clinical Medical Institute of Southern Medical University, Beijing 100700 (China)] [Affiliated Bayi Brain Hospital, The Military General Hospital of Beijing PLA,The Bayi Clinical Medical Institute of Southern Medical University, Beijing 100700 (China)

2013-06-14T23:59:59.000Z

91

Single-molecule modeling of mRNA degradation by miRNA: Lessons from data  

E-Print Network [OSTI]

Recent experimental results on the effect of miRNA on the decay of its target mRNA have been analyzed against a previously hypothesized single molecule degradation pathway. According to that hypothesis, the silencing complex (miRISC) first interacts with its target mRNA and then recruits the protein complexes associated with NOT1 and PAN3 to trigger deadenylation (and subsequent degradation) of the target mRNA. Our analysis of the experimental decay patterns allowed us to refine the structure of the degradation pathways at the single molecule level. Surprisingly, we found that if the previously hypothesized network was correct, only about 7% of the target mRNA would be regulated by the miRNA mechanism, which is inconsistent with the available knowledge. Based on systematic data analysis, we propose the alternative hypothesis that NOT1 interacts with miRISC before binding to the target mRNA. Moreover, we show that when miRISC binds alone to the target mRNA, the mRNA is degraded more slowly, probably through a deadenylation-independent pathway. The new biochemical pathway we propose both fits the data and paves the way for new experimental work to identify new interactions.

Celine Sin; Davide Chiarugi; Angelo Valleriani

2014-10-20T23:59:59.000Z

92

Controlling Rats and Mice  

E-Print Network [OSTI]

at least 18 inches off the ground. 18? 18? TCE?Wildlife Services P.O. Box 100410 ? San Antonio, Texas 78201-1710 Rat-proofing Whenever it can be accomplished at a rea- sonable cost, rat-proofing is recommended as the most permanent means of control...

Texas Wildlife Services

2007-03-13T23:59:59.000Z

93

APPENDIX A: SUPPLEMENTARY MATERIAL As we see in Fig. 2, the hub of the algorithm is the M matrix. Matrix element Mi  

E-Print Network [OSTI]

. Matrix element Mi j represents the best way to fold the prefixes s[1..i] and t[1..j] given that i and j are paired. Mi j = min Mi-1 j-1 + NN(i, j), (A1a) tstack(i - 1, j - 1) + Ginit + GAU/GU (i, j), (A1b) Mi-2 j-1 + NN (i, j, i - 2, j - 1) + Gbulge, (A1c) Mi-1 j-2 + NN (i, j, i - 1, j - 2) + Gbulge, (A1d) Mi-2

Aalberts, Daniel P.

94

Introduction The Fiber-Lite MI-150 is a 150 Watt quartz halogen fiber optic illuminator designed for general microscopy  

E-Print Network [OSTI]

Introduction ® The Fiber-Lite MI-150 is a 150 Watt quartz halogen fiber optic illuminator designed for general microscopy use. When used with specialty fiber optic cables the MI-150 illuminator can also Illuminator from the carton and retain the manual and any additional documents. ! Remove the fiber optic cable

Kleinfeld, David

95

Company City State Contact Info 21st Century Plastics Corporation Potterville MI www.21stcpc.com  

E-Print Network [OSTI]

Company City State Contact Info 21st Century Plastics Corporation Potterville MI www.21stcpc.com A. Schulman, Inc. Akron OH www.aschulman.com A.M.A. Plastics Riverside CA www.accordindustries.com Airlite Plastics Co. Omaha NE www.airliteplastics.com Alco Plastics, Inc. Romeo MI www

McGaughey, Alan

96

Expression of the multifunctional Y-box protein, YB-1, in myofibroblasts of the infarcted rat heart  

SciTech Connect (OSTI)

Intracellular signaling mechanisms regulating the turnover of {alpha}-SMA-positive myofibroblasts (myoFbs) at the site of myocardial infarction (MI) are poorly understood. Y-Box (YB)-1, a multifunctional protein, may be involved in regulation of proliferation, migration and apoptosis of myoFbs. Our objective was to study the expression of YB-1 in the infarcted rat heart and its localization in myoFbs. On days 3-28 following MI, we monitored YB-1 expression and its colocalization with {alpha}-SMA, and proliferation markers PCNA and Ki-67 in infarcted tissue by Western blot, immunohistochemistry, and immunofluorescent double-labeling. YB-1 is barely detectable in normal myocardium. At the infarct site, however, YB-1 is markedly elevated from day 3 post-MI concomitant with the induction of cell proliferation. MyoFbs are the major source of YB-1 and retain it up to day 28 post-MI. We suggest early expression of YB-1 promotes proliferation and migration of myoFbs, whereas prolonged expression may be responsible for scar formation.

Kamalov, German [Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163 (United States); Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN 38163 (United States); Varma, Balwantkumar R. [Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163 (United States); Lu Li [Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN 38163 (United States); Sun Yao [Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN 38163 (United States); Weber, Karl T. [Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN 38163 (United States); Guntaka, Ramareddy V. [Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163 (United States)]. E-mail: rguntaka@utmem.edu

2005-08-19T23:59:59.000Z

97

IL-1 beta and TNF-alpha upregulate angiotensin II type 1 (AT(1)) receptors on cardiac fibroblasts and are associated with increased AT(1) density in the post-MI heart  

E-Print Network [OSTI]

AT 1 density in the post-MI heart Devorah Gurantz a , Randypost-myocardial infarction (MI) cardiac remodeling. The Angnon-myocytes in the post- MI heart. We have shown that pro-

Gurantz, D; Cowling, R T; Varki, N; Frikovsky, E; Moore, C D; Greenberg, Barry H

2005-01-01T23:59:59.000Z

98

Los Estados Unidos como idea, estación y destino en el imaginario latinoamericano. Reseña de "Sam no es mi tío: Veinticuatro crónicas migrantes y un sueño americano" de Diego Fonseca y Aileen El-Kadi, eds.  

E-Print Network [OSTI]

Aileen El-Kadi, eds. Sam no es mi tío: Veinticuatro crónicasen la lectura de Sam no es mi tío. Veinticuatro crónicasuna antología como Sam no es mi tío nos indica que el ámbito

Corona, Ignacio

2012-01-01T23:59:59.000Z

99

miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn’s disease  

SciTech Connect (OSTI)

Highlights: •NOD2 is a target gene of miR-122. •miR-122 inhibits LPS-induced apoptosis by suppressing NOD2 in HT-29 cells. •miR-122 reduces the expression of pro-inflammatory cytokines (TNF-? and IFN-?). •miR-122 promotes the release of anti-inflammatory cytokines (IL-4 and IL-10). •NF-?B signaling pathway is involved in inflammatory response induced by LPS. -- Abstract: Crohn’s disease (CD) is one of the two major types of inflammatory bowel disease (IBD) thought to be caused by genetic and environmental factors. Recently, miR-122 was found to be deregulated in association with CD progression. However, the underlying molecular mechanisms remain unclear. In the present study, the gene nucleotide-binding oligomerization domain 2 (NOD2/CARD15), which is strongly associated with susceptibility to CD, was identified as a functional target of miR-122. MiR-122 inhibited LPS-induced apoptosis by suppressing NOD2 in HT-29 cells. NOD2 interaction with LPS initiates signal transduction mechanisms resulting in the activation of nuclear factor ?B (NF-?B) and the stimulation of downstream pro-inflammatory events. The activation of NF-?B was inhibited in LPS-stimulated HT-29 cells pretreated with miR-122 precursor or NOD2 shRNA. The expression of the pro-inflammatory cytokines TNF-? and IFN-? was significantly decreased, whereas therelease of the anti-inflammatory cytokines IL-4 and IL-10 was increased in LPS-stimulated HT-29 cells pretreated with miR-122 precursor, NOD2 shRNA or the NF-?B inhibitor QNZ. Taken together, these results indicate that miR-122 and its target gene NOD2 may play an important role in the injury of intestinal epithelial cells induced by LPS.

Chen, Yu; Wang, Chengxiao; Liu, Ying; Tang, Liwei; Zheng, Mingxia [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)] [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China); Xu, Chundi [Department of Pediatrics, Ruijin affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China)] [Department of Pediatrics, Ruijin affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China); Song, Jian, E-mail: jiansongkxy@126.com [Department of Gastroenterology, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)] [Department of Gastroenterology, Jiangwan Hospital of Shanghai, Shanghai 200434 (China); Meng, Xiaochun [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)] [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)

2013-08-16T23:59:59.000Z

100

MI-HYUN PARK, PhD Dept. of Civil and Environmental Engineering  

E-Print Network [OSTI]

and sustainability Stormwater runoff modeling and management Environmental informatics Decision support systems Areas Land use/climate change and human impact on water quality Urban watershed management of Best Management Practices for Urban Stormwater Management, Water Environment Research, in revision Mi

Mountziaris, T. J.

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

2000 JAPAN-USA Symposium on Flexible Automation July 23-26, 2000, Ann Arbor, MI  

E-Print Network [OSTI]

2000 JAPAN-USA Symposium on Flexible Automation July 23-26, 2000, Ann Arbor, MI 2000JUSFA-US1 OFF-LINE ERROR RECOVERY LOGIC SYNTHESIS IN AUTOMATED ASSEMBLY LINES BY USING GENETIC PROGRAMMING Cem M. Baydar by the experts or automated error recovery logic controllers embedded in the system. The previous work

Saitou, Kazuhiro "Kazu"

102

Steps to Assemble a MiNT Node I. HARDWARE COMPONENTS WITH VENDOR LIST  

E-Print Network [OSTI]

Steps to Assemble a MiNT Node I. HARDWARE COMPONENTS WITH VENDOR LIST The following list · Vendor: http://www.mikrotik.com · Comments: RouterBoard 230 is a small form- factor embedded computing be purchased separately from the same vendor. Hence, one must buy a Compact Flash card which is used as the non

Chiueh, Tzi-cker

103

Academic Staff ESS Coversheet Candidate Name (Last, First, M.I.) Banner ID  

E-Print Network [OSTI]

rev. 6/14 Academic Staff ESS Coversheet Candidate Name (Last, First, M.I.) Banner ID Primary School Initial WSU appointment date Length of ESS-track service (in years & months) Academic Services Officer Archivist Initial WSU rank Dates off ESS-track/Reason Extens Prgm Coordinator Financial Aid Officer Date

VandeVord, Pamela

104

We investigated the effects of deforestation on mi-croclimates and sporogonic development of Plasmodium  

E-Print Network [OSTI]

We investigated the effects of deforestation on mi- croclimates and sporogonic development membrane feeders. Fed mosquitoes were placed in houses in forested and deforest- ed areas in a highland area (1,500 m above sea level) and monitored for parasite development. Deforested sites had higher

Obbard, Darren

105

Organic scintillation detector response simulation using non-analog MCNPX-PoliMi  

SciTech Connect (OSTI)

Organic liquid scintillation detectors are valuable for the detection of special nuclear material since they are capable of detecting both neutrons and gamma rays. Scintillators can also provide energy information which is helpful in identification and characterization of the source. In order to design scintillation based measurement systems appropriate simulation tools are needed. MCNPX-PoliMi is capable of simulating scintillation detector response; however, simulations have traditionally been run in analog mode which leads to long computation times. In this paper, non-analog MCNPX-PoliMi mode which uses variance reduction techniques is applied and tested. The non-analog MCNPX-PoliMi simulation test cases use source biasing, geometry splitting and a combination of both variance reduction techniques to efficiently simulate pulse height distribution and then time-of-flight for a heavily shielded case with a {sup 252}Cf source. An improvement factor (I), is calculated for distributions in each of the three cases above to analyze the effectiveness of the non-analog MCNPX-PoliMi simulations in reducing computation time. It is found that of the three cases, the last case which uses a combination of source biasing and geometry splitting shows the most improvement in simulation run time for the same desired variance. For pulse height distributions speedup ranging from a factor 5 to 25 is observed, while for time-of-flights the speedup factors range from 3 to 10. (authors)

Prasad, S.; Clarke, S. D.; Pozzi, S. A.; Larsen, E. W. [Univ. of Michigan, 2355 Bonisteel Blvd., Ann Arbor, MI 48109 (United States)

2012-07-01T23:59:59.000Z

106

Nitrate-responsive miR393/AFB3 regulatory module controls root system architecture in  

E-Print Network [OSTI]

environmental conditions is the modulation of root system architecture (RSA) in response to nitrate supplyNitrate-responsive miR393/AFB3 regulatory module controls root system architecture in ArabidopsisR393/AFB3 is a unique N- responsive module that controls root system architecture in response

Green, Pamela

107

L.van BEETHOVEN : Quatuor n10 en Mi bmol majeur, Op.74 Poco Adagio -Allegro -  

E-Print Network [OSTI]

L.van BEETHOVEN : Quatuor n°10 en Mi bémol majeur, Op.74 Poco Adagio - Allegro - Adagio ma non con variazioni- Allegro Après le coup de tonnerre que représentait l'achèvement des trois quatuors à apportent une tension qui se fond dans un grand crescendo menant à l'Allegro. Trois accords joyeux pour un

Mazliak, Laurent

108

SAE 1983 Transactions, Paper No. 830200, pp. 1.810-1.816 International Congress & Exposition, Detroit, Mi., Feb. 28-March 4, 1983  

E-Print Network [OSTI]

, Detroit, Mi., Feb. 28- March 4, 1983 #12;SAE 1983 Transactions, Paper No. 830200, pp. 1.810-1.816 International Congress & Exposition, Detroit, Mi., Feb. 28- March 4, 1983 #12;SAE 1983 Transactions, Paper No. 830200, pp. 1.810-1.816 International Congress & Exposition, Detroit, Mi., Feb. 28- March 4, 1983 Fig. 2

Radcliffe, Clark J.

109

Emploi du temps Licence de Mathmatiques semestre 6 MA= parcours maths approfondies M= parcours maths MI= parcours math-info ( groupe A en LI2)  

E-Print Network [OSTI]

M= parcours maths MI= parcours math-info ( groupe A en LI2) 08h00-09h30 09h45-11h15 11h30-13h00 13h15-14h45 15h00-16h30 16h45-18h15 lundi MA MA M Anglais* M MI TP Programmation C PV202 MI mardi MA Anglais MA M TD Histoire des Maths M 3.2 M MI TP Projet Scientifique PV214 MI mercredi MA TD Variable

Parusinski, Adam

110

1 Mo 1 Do 1 Sa 1 Di 1 Fr 1 Fr 1 Mo 1 Mi 1 Sa 1 Mo 1 Do 1 So 2 Di 2 Fr 2 So 2 Mi 2 Sa 2 Sa 2 Di 2 Do 2 So 2 Di 2 Fr 2 Mo  

E-Print Network [OSTI]

1 Mo 1 Do 1 Sa 1 Di 1 Fr 1 Fr 1 Mo 1 Mi 1 Sa 1 Mo 1 Do 1 So 2 Di 2 Fr 2 So 2 Mi 2 Sa 2 Sa 2 Di 2 Do 2 So 2 Di 2 Fr 2 Mo 3 Mi 3 Sa 3 Mo 3 Do 3 So 3 So 3 Mi 3 Fr 3 Mo 3 Mi 3 Sa 3 Di 4 Do 4 So 4 Di 4 Fr 4 Mo 4 Mo 4 Do 4 Sa 4 Di 4 Do P StAU4 So 4 Mi 5 Fr 5 Mo 5 Mi 5 Sa 5 Di 5 Di 5 Fr 5 So 5 Mi 5 Fr 5 Mo

Mayberry, Marty

111

Measurement of Pi-K Ratios from the NuMI Target  

SciTech Connect (OSTI)

Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 10{sup 6} events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of {pi}{sup -}/{pi}{sup +}, K{sup -}/K{sup +}, {pi}{sup +}/K{sup +} and {pi}{sup -}/K{sup -} production ratios in the momentum range p{sub T} < 2 GeV/c transversely and 20 GeV/c < p{sub z} < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.

Seun, Sin Man; /Harvard U.

2007-07-01T23:59:59.000Z

112

Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro  

SciTech Connect (OSTI)

Highlight: •MiR-21 plays a significant role in 5-FU resistance. •This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. •Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.

Deng, Jun; Lei, Wan; Fu, Jian-Chun; Zhang, Ling; Li, Jun-He; Xiong, Jian-Ping, E-mail: jpxiong@medmail.com.cn

2014-01-17T23:59:59.000Z

113

Super Rat Poison Man  

E-Print Network [OSTI]

Bob Square Tie. But Zheng Xiaoyu, the deposed head of China's State Food and Drug Administration begs to be excused. A rat poison manufacturer here in China applied for permission to name some of its products after him, partly because he's corrupt...

Hacker, Randi; Tsutsui, William

2007-04-04T23:59:59.000Z

114

Tritium transport in the NuMI decay pipe region - modeling and comparison with experimental data  

SciTech Connect (OSTI)

The NuMI (Neutrinos at Main Injector) beam facility at Fermilab is designed to produce an intense beam of muon neutrinos to be sent to the MINOS underground experiment in Soudan, Minnesota. Neutrinos are created by the decay of heavier particles. In the case of NuMI, the decaying particles are created by interaction of high-energy protons in a target, creating mostly positive pions. These particles can also interact with their environment, resulting in production of a variety of short-lived radionuclides and tritium. In the NuMI beam, neutrinos are produced by 120 GeV protons from the Fermilab Main Injector accelerator which are injected into the NuMI beam line using single turn extraction. The beam line has been designed for 400 kW beam power, roughly a factor of 2 above the initial (2005-06) running conditions. Extracted protons are bent downwards at a 57mr angle towards the Soudan Laboratory. The meson production target is a 94 cm segmented graphite rod, cooled by water in stainless tubes on the top and bottom of the target. The target is followed by two magnetic horns which are pulsed to 200 kA in synchronization with the passage of the beam, producing focusing of the secondary hadron beam and its daughter neutrinos. Downstream of the second horn the meson beam is transported for 675 m in an evacuated 2 m diameter beam (''decay'') pipe. Subsequently, the residual mesons and protons are absorbed in a water cooled aluminum/steel absorber immediately downstream of the decay pipe. Some 200 m of rock further downstream ranges out all of the residual muons. During beam operations, after installation of the chiller condensate system in December 2005, the concentration of tritiated water in the MINOS sump flow of 177 gpm was around 12 pCi/ml, for a total of 0.010 pCi/day. A simple model of tritium transport and deposition via humidity has been constructed to aid in understanding how tritium reaches the sump water. The model deals with tritium transported as HTO, water in which one hydrogen atom has been replaced with tritium. Based on concepts supported by the modeling, a dehumidification system was installed during May 2006 that reduced the tritium level in the sump by a factor of two. This note is primarily concerned with tritium that was produced in the NuMI target pile, carried by air flow into the target hall and down the decay pipe passageway (where most of it was deposited). The air is exhausted through the existing air vent shaft EAV2 (Figure 1).

Hylen, J.; Plunkett, R.; /Fermilab

2007-03-01T23:59:59.000Z

115

MiR-145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1  

SciTech Connect (OSTI)

Highlights: •MiR-145 is downregulated in human ovarian cancer. •MiR-145 targets p70S6K1 and MUC1. •p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3?UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.

Wu, Huijuan [Department of Gynecological Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060 (China)] [Department of Gynecological Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060 (China); Xiao, ZhengHua [Department of gynecology, Yongchuan Affiliated Hospital of Chongqing Medical University, Chongqing City 404100 (China)] [Department of gynecology, Yongchuan Affiliated Hospital of Chongqing Medical University, Chongqing City 404100 (China); Wang, Ke; Liu, Wenxin [Department of Gynecological Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060 (China)] [Department of Gynecological Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060 (China); Hao, Quan, E-mail: quanhao2002@163.com [Department of Gynecological Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060 (China)] [Department of Gynecological Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060 (China)

2013-11-29T23:59:59.000Z

116

A Large Liquid Argon TPC for Off-axis NuMI Neutrino Physics  

SciTech Connect (OSTI)

The ICARUS collaboration has shown the power of the liquid argon time projection chamber (LArTPC) technique to image events with bubble-chamber-like quality. I will describe a proposed long-baseline {nu}e appearance experiment utilizing a large ({>=} 15 kton1) LArTPC placed off-axis of Fermilab's NuMI {nu}{mu} beam. The total LArTPC program as it presently stands, which includes a number of smaller R and D projects designed to examine the key design issues, will be outlined.

Menary, Scott [York University, Toronto (Canada)

2006-07-11T23:59:59.000Z

117

Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment  

SciTech Connect (OSTI)

The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% {bar {nu}}{sub {mu}}, which can be separated from the {nu}{sub {mu}} because the MINOS detectors are magnetized. This makes it possible to study {bar {nu}}{sub {mu}} oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the {bar {nu}}{sub {mu}} oscillation parameters and comparing them with those for {nu}{sub {mu}}, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam {bar {nu}}{sub {mu}} before. It is also possible to produce an almost pure {bar {nu}}{sub {mu}} beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% {bar {nu}}{sub {mu}} component of the forward horn current NuMI beam. The {bar {nu}}{sub {mu}} of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3{sub -7.6}{sup +7.6}(stat.){sub -3.6}{sup +3.6}(syst.) events. This corresponds to a 1.9 {sigma} deficit, and a best fit value of {Delta}{bar m}{sub 32}{sup 2} = 18 x 10{sup -3} eV{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23} = 0.55. This thesis focuses particularly on the selection of {bar {nu}}{sub {mu}} events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the precision of {Delta}{bar m}{sub 32}{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23}. Furthermore, it describes a study to determine the gains of the PMTs via the single-photoelectron spectrum. The results were used as a crosscheck of the gains determined at higher intensities by an LED-based light-injection system.

Auty, David John; /Sussex U.

2010-05-01T23:59:59.000Z

118

UCRL-MI-224010 ARM-06-012 ARM's Support for GCM Improvement: A White Paper  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered energy consumption by sectorlong version) The U.S.1,summer gasolineUCNÏ„MI-224010

119

DOE - Office of Legacy Management -- Naval Ordnance Plant - MI 0-03  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou are herePA 3003A AECMexico - NMPlant - MI

120

Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Adrenaline increases colon cancer cell proliferation and its resistance to cisplatin. Black-Right-Pointing-Pointer Adrenaline activates NF{kappa}B in a dose dependent manner. Black-Right-Pointing-Pointer NF{kappa}B-miR-155 pathway contributes to cell proliferation and resistance to cisplatin. -- Abstract: Recently, catecholamines have been described as being involved in the regulation of cancer genesis and progression. Here, we reported that adrenaline increased the cell proliferation and decreased the cisplatin induced apoptosis in HT29 cells. Further study found that adrenaline increased miR-155 expression in an NF{kappa}B dependent manner. HT29 cells overexpressing miR-155 had a higher cell growth rate and more resistance to cisplatin induced apoptosis. In contrast, HT29 cells overexpressing miR-155 inhibitor displayed decreased cell proliferation and sensitivity to cisplatin induced cell death. In summary, our study here revealed that adrenaline-NF{kappa}B-miR-155 pathway at least partially contributes to the psychological stress induced proliferation and chemoresistance in HT29 cells, shedding light on increasing the therapeutic strategies of cancer chemotherapy.

Pu, Jun [Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China)] [Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China); Bai, Danna [Department of Cardiology, 323 Hospital of PLA, Xi'an 710054 (China)] [Department of Cardiology, 323 Hospital of PLA, Xi'an 710054 (China); Yang, Xia [Department of Teaching and Medical Administration, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China)] [Department of Teaching and Medical Administration, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China); Lu, Xiaozhao [Department of Nephrology, The 323 Hospital of PLA, Xi'an 710054 (China)] [Department of Nephrology, The 323 Hospital of PLA, Xi'an 710054 (China); Xu, Lijuan, E-mail: 13609296272@163.com [Department of Nephrology, The 323 Hospital of PLA, Xi'an 710054 (China)] [Department of Nephrology, The 323 Hospital of PLA, Xi'an 710054 (China); Lu, Jianguo, E-mail: lujianguo029@yahoo.com.cn [Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China)] [Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China)

2012-11-16T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Problem 65 in Section 4.1 (Page 274) Constructing a pipeline Supertankers off-load oil at a docking facility 4 mi offshore. The nearest refinery  

E-Print Network [OSTI]

facility 4 mi offshore. The nearest refinery is 9 mi east of the shore point nearest the docking facility. A pipeline must be constructed connecting the docking facility with the refinery. The pipeline costs $300.42 miles away from the refinery, or equivalently 3.58 miles away from Point A (as the back of the book has

Schilling, Anne

122

To cite this document: Fernandez, Mayra and Barroso, Benot and Meyer, Michel and Meyer, Xuan Mi and  

E-Print Network [OSTI]

To cite this document: Fernandez, Mayra and Barroso, Benoît and Meyer, Michel and Meyer, Xuan Mi and modelling M. F. Fernandeza,b,c,d,e , B. Barrosoe , X. M. Meyera* , M. Meyera , M.-V. Le Lannb,c , G. Le

Mailhes, Corinne

123

MiSer: An Optimal Low-Energy Transmission Strategy for IEEE 802.11a/h  

E-Print Network [OSTI]

at appropriate moments to save battery energy. An alternative way to conserve energy is to apply TPC (Trans- mitMiSer: An Optimal Low-Energy Transmission Strategy for IEEE 802.11a/h Daji Qiao+ Sunghyun Choi the energy consumption by wireless communication de- vices is perhaps the most important issue in the widely

Qiao, Daji

124

Corrosion mechanisms of low level vitrified radioactive waste in a loamy soil M.I. Ojovan1  

E-Print Network [OSTI]

Corrosion mechanisms of low level vitrified radioactive waste in a loamy soil M.I. Ojovan1 , W to 19 o C. Both ion-exchange and hydrolysis control the corrosion of this glass. Processing of field disposal facilities, which presumes an understanding of the main glass corrosion mechanisms. The corrosion

Sheffield, University of

125

Society of Automotive Engineers World Congress and Exposition, Detroit, MI, April, 2006 (draft) 1 MEASURING INDUSTRIAL ENERGY SAVINGS  

E-Print Network [OSTI]

Society of Automotive Engineers World Congress and Exposition, Detroit, MI, April, 2006 (draft) 1 MEASURING INDUSTRIAL ENERGY SAVINGS Kelly Kissock and Carl Eger Department of Mechanical and Aerospace Engineering University of Dayton 300 College Park Dayton, Ohio 45469-0238 Abstract This paper presents

Kissock, Kelly

126

Methods for Isolation of Total RNA to Recover miRNAs and Other Small RNAs from Diverse Species  

E-Print Network [OSTI]

) size range, the first and most important step is the isolation of high-quality total RNA. Because RNA will present a set of total RNA isolation methods that can be used to maximize the recovery of high-quality RNAChapter 3 Methods for Isolation of Total RNA to Recover miRNAs and Other Small RNAs from Diverse

Green, Pamela

127

Observation of Disappearance of Muon Neutrinos in the NuMI Beam  

SciTech Connect (OSTI)

The Main Injector Neutrino Oscillation Search (MINOS) is a two detector long-baseline neutrino experiment designed to study the disappearance of muon neutrinos. MINOS will test the {nu}{sub {mu}} {yields} {nu}{sub {tau}} oscillation hypothesis and measure precisely {Delta}m{sub 23}{sup 2} and sin{sup 2} 2{theta}{sub 23} oscillation parameters. The source of neutrinos for MINOS experiment is Fermilab's Neutrinos at the Main Injector (NuMI) beamline. The energy spectrum and the composition of the beam is measured at two locations, one close to the source and the other 735 km down-stream in the Soudan Mine Underground Laboratory in northern Minnesota. The precision measurement of the oscillation parameters requires an accurate prediction of the neutrino flux at the Far Detector. This thesis discusses the calculation of the neutrino flux at the Far Detector and its uncertainties. A technique that uses the Near Detector data to constrain the uncertainties in the calculation of the flux is described. The data corresponding to an exposure of 2.5 x 10{sup 20} protons on the NuMI target is presented and an energy dependent disappearance pattern predicted by neutrino oscillation hypotheses is observed in the Far Detector data. The fit to MINOS data, for given exposure, yields the best fit values for {Delta}m{sub 23}{sup 2} and sin{sup 2} 2{theta}{sub 23} to be (2.38{sub -0.16}{sup +0.20}) x 10{sup -3} eV{sup 2}/c{sup 4} and 1.00{sub -0.08}, respectively.

Pavlovic, Zarko; /Texas U.

2008-05-01T23:59:59.000Z

128

W gamma production in hadronic collisions using the POWHEG+MiNLO method  

E-Print Network [OSTI]

We detail a calculation of W gamma production in hadronic collision, at Next-to-Leading Order (NLO) QCD interfaced to a shower generator according to the POWHEG prescription supplemented with the MiNLO procedure. The fixed order result is matched to an interleaved QCD+QED parton shower, in such a way that the contribution arising from hadron fragmentation into photons is fully modeled. In general, our calculation illustrates a new approach to the fully exclusive simulation of prompt photon production processes accurate at the NLO level in QCD. We compare our predictions to those of the NLO program MCFM, which treats the fragmentation contribution in terms of photon fragmentation functions. We also perform comparisons to available LHC data at 7 TeV, for which we observe good agreement, and provide phenomenological results for physics studies of the W gamma production process at the Run II of the LHC. The new tool, which includes W leptonic decays and the contribution of anomalous gauge couplings, allows a full...

Barze, Luca

2014-01-01T23:59:59.000Z

129

W gamma production in hadronic collisions using the POWHEG+MiNLO method  

E-Print Network [OSTI]

We detail a calculation of W gamma production in hadronic collision, at Next-to-Leading Order (NLO) QCD interfaced to a shower generator according to the POWHEG prescription supplemented with the MiNLO procedure. The fixed order result is matched to an interleaved QCD+QED parton shower, in such a way that the contribution arising from hadron fragmentation into photons is fully modeled. In general, our calculation illustrates a new approach to the fully exclusive simulation of prompt photon production processes accurate at the NLO level in QCD. We compare our predictions to those of the NLO program MCFM, which treats the fragmentation contribution in terms of photon fragmentation functions. We also perform comparisons to available LHC data at 7 TeV, for which we observe good agreement, and provide phenomenological results for physics studies of the W gamma production process at the Run II of the LHC. The new tool, which includes W leptonic decays and the contribution of anomalous gauge couplings, allows a fully exclusive, hadron-level description of the W gamma process, and is publicly available at the repository of the POWHEG BOX. Our approach can be easily adapted to deal with other relevant isolated photon production processes in hadronic collisions.

Luca Barze; Mauro Chiesa; Guido Montagna; Paolo Nason; Oreste Nicrosini; Fulvio Piccinini; Valeria Prosperi

2014-12-10T23:59:59.000Z

130

Measurement of Charged Pion Production Yields off the NuMI Target  

E-Print Network [OSTI]

The fixed-target MIPP experiment, Fermilab E907, was designed to measure the production of hadrons from the collisions of hadrons of momenta ranging from 5 to 120 GeV/c on a variety of nuclei. These data will generally improve the simulation of particle detectors and predictions of particle beam fluxes at accelerators. The spectrometer momentum resolution is between 3 and 4%, and particle identification is performed for particles ranging between 0.3 and 80 GeV/c using $dE/dx$, time-of-flight and Cherenkov radiation measurements. MIPP collected $1.42 \\times10^6$ events of 120 GeV Main Injector protons striking a target used in the NuMI facility at Fermilab. The data have been analyzed and we present here charged pion yields per proton-on-target determined in bins of longitudinal and transverse momentum between 0.5 and 80 GeV/c, with combined statistical and systematic relative uncertainties between 5 and 10%.

J. M. Paley; M. D. Messier; R. Raja; U. Akgun; D. M. Asner; G. Aydin; W. Baker; P. D. Barnes, Jr.; T. Bergfeld; L. Beverly; V. Bhatnagar; B. Choudhary; E. C. Dukes; F. Duru; G. J. Feldman; A. Godley; N. Graf; J. Gronberg; E. Gulmez; Y. O. Gunaydin; H. R. Gustafson; E. P. Hartouni; P. Hanlet; M. Heffner; D. M. Kaplan; O. Kamaev; J. Klay; A. Kumar; D. J. Lange; A. Lebedev; J. Ling; M. J. Longo; L. C. Lu; C. Materniak; S. Mahajan; H. Meyer; D. E. Miller; S. R. Mishra; K. Nelson; T. Nigmanov; A. Norman; Y. Onel; A. Penzo; R. J. Peterson; D. Rajaram; D. Ratnikov; C. Rosenfeld; H. Rubin; S. Seun; A. Singh; N. Solomey; R. A. Soltz; Y. Torun; K. Wilson; D. M. Wright; Q. K. Wu

2014-04-23T23:59:59.000Z

131

A new 'Implicit correlation' method for cross-correlation sampling in MCNPX-PoliMi  

SciTech Connect (OSTI)

Monte Carlo particle transport codes used to accurately model detector response are traditionally run in fully analog mode. Analog simulations of cross-correlation measurements with these codes are extremely time-consuming because the probability of correlated detection is extremely small, approximately equal to the product of the probabilities of a single detection in each detector. The new 'implicit correlation' method described here increases the number of correlation event scores thereby reducing variance and required computation times. The cost of the implicit correlation method is comparable to the cost of simulating single event detection for the lowest absolute detector efficiency in the problem. This method is especially useful in the nuclear non-proliferation and safeguards fields for simulating correlation measurements of shielded special nuclear material. The new method was implemented in MCNPX-PoliMi for neutron-neutron cross-correlations with a Cf-252 spontaneous fission source measured by two detectors of variable stand-offs. The method demonstrated good agreement with analog simulation results for multiple measurement geometries. Small differences between non-analog and analog cross-correlation distributions are attributed to known features of the specific problem simulated that will not be present in practical applications. (authors)

Marcath, M. J.; Larsen, E. W.; Clarke, S. D.; Pozzi, S. A. [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, 2355 Bonisteel Boulevard, Ann Arbor, MI, 48109-2104 (United States)

2013-07-01T23:59:59.000Z

132

LBNL RUNAROUND RESULTS 3.00 km (1.86 mi) October 10, 2003 TOP GROUP STANDINGS FOR 2003  

E-Print Network [OSTI]

LBNL RUNAROUND RESULTS 3.00 km (1.86 mi) October 10, 2003 page 1 TOP GROUP STANDINGS FOR 2003 , Anton not LBNL 7 11:18.8 Singer, Brett C 30-39 men 3 8 11:20.2 Yegian, Derek 30-39 men 4 9 11:20.4 Nihei 45 13:26.9 card not turned in 46 13:27.4 Elliott, James B 30-39 men 18 #12;LBNL RUNAROUND RESULTS 3

133

Program Subject(S) required in Program tyPe addition to engliSh S ma mi  

E-Print Network [OSTI]

Program Subject(S) required in Program tyPe addition to engliSh S ma mi comPuter Science (bSc) Computer Science C x x x humanitieS (ba) Aboriginal Studies (J) x x x African Studies (J) x x x American Studies (J) x x x Celtic Studies x x x Christianity and Culture x x x Christianity and Education x Cinema

134

B.SMETANA: Quatuor n1 en mi mineur "Z mho Zivota " ("De ma vie ") Allegro vivo appassionnato-Allegro moderato alla Polka-Largo sostenuto-Vivace  

E-Print Network [OSTI]

B.SMETANA: Quatuor n°1 en mi mineur "Z mého Zivota " ("De ma vie ") Allegro vivo appassionnato- Allegro moderato alla Polka- Largo sostenuto- Vivace Dans la nuit du 19 au 20 octobre 1874, Smetana

Mazliak, Laurent

135

Executive summary of major NuMI lessons learned: a review of relevant meetings of Fermilab's DUSEL Beamline Working Group  

SciTech Connect (OSTI)

We have gained tremendous experience with the NuMI Project on what was a new level of neutrino beams from a high power proton source. We expect to build on that experience for any new long baseline neutrino beam. In particular, we have learned about some things which have worked well and/or where the experience is fairly directly applicable to the next project (e.g., similar civil construction issues including: tunneling, service buildings, outfitting, and potential claims/legal issues). Some things might be done very differently (e.g., decay pipe, windows, target, beam dump, and precision of power supply control/monitoring). The NuMI experience does lead to identification of critical items for any future such project, and what issues it will be important to address. The DUSEL Beamline Working Group established at Fermilab has been meeting weekly to collect and discuss information from that NuMI experience. This document attempts to assemble much of that information in one place. In this Executive Summary, we group relevant discussion of some of the major issues and lessons learned under seven categories: (1) Differences Between the NuMI Project and Any Next Project; (2) The Process of Starting Up the Project; (3) Decision and Review Processes; (4) ES&H: Environment, Safety, and Health; (5) Local Community Buy-In; (6) Transition from Project Status to Operation; and (7) Some Lessons on Technical Elements. We concentrate here on internal project management issues, including technical areas that require special attention. We cannot ignore, however, two major external management problems that plagued the NuMI project. The first problem was the top-down imposition of an unrealistic combination of scope, cost, and schedule. This situation was partially corrected by a rebaselining. However, the full, desirable scope was never achievable. The second problem was a crippling shortage of resources. Critical early design work could not be done in a timely fashion, leading to schedule delays, inefficiencies, and corrective actions. The Working Group discussions emphasized that early planning and up-front appreciation of the problems ahead are very important for minimizing the cost and for the greatest success of any such project. Perhaps part of the project approval process should re-enforce this need. The cost of all this up-front work is now reflected in the DOE cost of any project we do. If we are being held to an upper limit on the project cost, the only thing available for compromise is the eventual project scope.

Andrews, Mike; Appel, Jeffrey A.; Bogert, Dixon; Childress, Sam; Cossairt, Don; Griffing, William; Grossman, Nancy; Harding, David; Hylen, Jim; Kuchler, Vic; Laughton, Chris; /Fermilab /Argonne /Brookhaven /LBL, Berkeley

2009-05-01T23:59:59.000Z

136

Genome sequence of the Brown Norway rat yields insights into  

E-Print Network [OSTI]

Genome sequence of the Brown Norway rat yields insights into mammalian evolution Rat Genome Norway (BN) rat strain. The sequence represents a high-quality `draft' covering over 90% of the genome

Pachter, Lior

137

Table 2 -Lime use and practices on Corn, major producing states, 2001 CO GA IL IN IA KS KY MI MN MO NE NY NC ND OH PA SD TX WI Area  

E-Print Network [OSTI]

Table 2 - Lime use and practices on Corn, major producing states, 2001 CO GA IL IN IA KS KY MI MN.7 Table 2 - Lime use and practices on Corn, major producing states, 2000 CO IL IN IA KS KY MI MN MO NE NY use and practices on Corn, major producing states, 1999 CO IL IN IA KS KY MI MN MO NE NC OH SD TX WI

Kammen, Daniel M.

138

Mitsubishi iMiEV: An Electric Mini-Car in NREL's Advanced Technology Vehicle Fleet (Fact Sheet)  

SciTech Connect (OSTI)

This fact sheet highlights the Mitsubishi iMiEV, an electric mini-car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In support of the U.S. Department of Energy's fast-charging research efforts, NREL engineers are conducting charge and discharge performance testing on the vehicle. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, and emerging technologies.

Not Available

2011-10-01T23:59:59.000Z

139

Water Retrieval by Norway Rats: Behavior as Deduction  

E-Print Network [OSTI]

1948). Burrows and feeding of the Norway a radial Mammalogy,Object retrieval preferences of Norway rats: An evolutionaryinedible objects by Norway rats: Motivational interactions

Wallace, R J

1998-01-01T23:59:59.000Z

140

albino rats rattus: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

albino rat cfn: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

142

albino wistar rats: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

143

albino rats exposed: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

144

albino rat anatomical: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

145

Stress effect on magnetoimpedance (MI) in amorphous wires at GHz frequencies and application to stress-tunable microwave composite materials  

E-Print Network [OSTI]

The effect of tensile stress on magnetoimpedance (MI) in CoMnSiB amorphous wires at microwave frequencies (0.5-3 GHz) is investigated both experimentally and theoretically. In the presence of the dc bias magnetic field of the order of the anisotropy field, the impedance shows very large and sensitive change when the wire is subjected to a tensile stress: 100% and 60% per 180 MPa for frequencies 500 MHz and 2.5 GHz, respectively. It is demonstrated that this behavior owes mainly to the directional change in the equilibrium magnetization caused by the applied stress and field, which agrees well with the theoretical results for the surface impedance. This stress effect on MI is proposed to use for creating microwave stress-tunable composite materials containing short magnetic wires. The analysis of the dielectric response from such materials shows that depending on the stress level in the material, the dispersion of the effective permittivity can be of a resonant or relaxation type with a considerable change in its values (up to 100% at 600 MPa). This media can be used for structural stress monitoring by microwave contrast imaging.

L. V. Panina; S. I. Sandacci; D. P. Makhnovskiy

2004-11-18T23:59:59.000Z

146

Bioreactor Landfill Research and Demonstration Project Northern Oaks Landfill, Harrison, MI  

SciTech Connect (OSTI)

A bioreactor landfill cell with 1.2-acre footprint was constructed, filled, operated, and monitored at Northern Oaks Recycling and Disposal Facility (NORDF) at Harrison, MI. With a filled volume of 74,239 cubic yards, the cell contained approximately 35,317 tons of municipal solid waste (MSW) and 20,777 tons of cover soil. It was laid on the slope of an existing cell but separated by a geosynthetic membrane liner. After the cell reached a design height of 60 feet, it was covered with a geosynthetic membrane cap. A three-dimensional monitoring system to collect data at 48 different locations was designed and installed during the construction phase of the bioreactor cell. Each location had a cluster of monitoring devices consisting of a probe to monitor moisture and temperature, a leachate collection basin, and a gas sampling port. An increase in moisture content of the MSW in the bioreactor cell was achieved by pumping leachate collected on-site from various other cells, as well as recirculation of leachate from the bioreactor landfill cell itself. Three types of leachate injection systems were evaluated in this bioreactor cell for their efficacy to distribute pumped leachate uniformly: a leachate injection pipe buried in a 6-ft wide horizontal stone mound, a 15-ft wide geocomposite drainage layer, and a 60-ft wide geocomposite drainage layer. All leachate injection systems were installed on top of the compacted waste surface. The distribution of water and resulting MSW moisture content throughout the bioreactor cell was found to be similar for the three designs. Water coming into and leaving the cell (leachate pumped in, precipitation, snow, evaporation, and collected leachate) was monitored in order to carry out a water balance. Using a leachate injection rate of 26 – 30 gal/yard3, the average moisture content increased from 25% to 35% (wet based) over the period of this study. One of the key aspects of this bioreactor landfill study was to evaluate bioreactor start up and performance in locations with colder climate. For lifts filled during the summer months, methane generation started within three months after completion of the lift. For lifts filled in winter months, very little methane production occurred even eight months after filling. The temperature data indicated that subzero or slightly above zero (oC) temperatures persisted for unusually long periods (more than six months) in the lifts filled during winter months. This was likely due to the high thermal insulation capability of the MSW and the low level of biological activity during start up. This observation indicates that bioreactor landfills located in cold climate and filled during winter months may require mechanisms to increase temperature and initiate biodegradation. Thus, besides moisture, temperature may be the next important factor controlling the biological decomposition in anaerobic bioreactor landfills. Spatial and temporal characterization of leachate samples indicated the presence of low levels of commonly used volatile organic compounds (including acetone, methyl ethyl ketone, methyl isobutyl ketone, and toluene) and metals (including arsenic, chromium, and zinc). Changes and leachate and gaseous sample characteristics correlated with enhanced biological activity and increase in temperature. Continued monitoring of this bioreactor landfill cell is expected to yield critical data needed for start up, design, and operation of this emerging process.

Zhao, Xiando; Voice, Thomas; and Hashsham, Syed A.

2006-08-29T23:59:59.000Z

147

Ethanol Consumption by Rat Dams During Gestation,  

E-Print Network [OSTI]

Ethanol Consumption by Rat Dams During Gestation, Lactation and Weaning Increases Ethanol examined effects of ethanol consumption in rat dams during gestation, lactation, and weaning on voluntary ethanol consumption by their adolescent young. We found that exposure to an ethanol-ingesting dam

Galef Jr., Bennett G.

148

The Metabolism of Americium in the Rat  

E-Print Network [OSTI]

t _ 'mE METABOLISM OF AMERICIUM IN THE RAT* By K. G. Scott,The distri :.1). tl.on of americium in the bone was studied,48A THE METABOLISM OF AMERICIUM IN THE RAT By K. G. Scott,

Scott, K.G.

2010-01-01T23:59:59.000Z

149

Tag 1 Tag 2 Tag 3 Tag 4 Tag 5 Tag 6 Tag 7 Tag 8 Tag 9 Tag 10 G3=W11/3 Mo 18.11.2013 Di 19.11.2013 Mi 20.11.2013 Do 21.11.2013 Fr 22.11.2013 Mo 25.11.2013 Di 26.11.2013 Mi 27.11.2013 Do 28.11.2013 Fr 29.11.2013  

E-Print Network [OSTI]

.11.2013 Mi 20.11.2013 Do 21.11.2013 Fr 22.11.2013 Mo 25.11.2013 Di 26.11.2013 Mi 27.11.2013 Do 28.11.2013 Fr 29.11.2013 G2=W11/2 Mo 02.12.2013 Di 03.12.2013 Mi 04.12.2013 Do 05.12.2013 Fr 06.12.2013 Mo 09.12.2013 Di 10.12.2013 Mi 11.12.2013 Do 12.12.2013 Fr 13.12.2013 G1=W11/1 Mo Feiertag Di 07.01.2014 Mi 08

Schubart, Christoph

150

Society of Automotive Engineers (SAE) Technical Paper 2006-01-1041 Paper presented at SAE 2006 World Congress & Exposition, April 5, 2006, Detroit, MI  

E-Print Network [OSTI]

and Fundamental Advances in Thermal Fluid Sciences 2006. Vol. SP-2015. (Society of Automotive Engineers, Troy, MI by Multi-Orifice Direct Injection Using Ultrafast X-Tomography Technique Xin Liu, Kyoung-Su Im, Yujie Wang-pressure direct injection fuel system for spark ignition direct injection engines has been developed, in which

Gruner, Sol M.

151

Michigan State University Community Music School 841-B Timberlane Street East Lansing, MI 48823 Phone: 517-355-7661 Web: cms.msu.edu  

E-Print Network [OSTI]

Michigan State University Community Music School 841-B Timberlane Street · East Lansing, MI 48823 Explore Michigan's past through tour of music, exhibits May 1 Contact: Amanda Darche, MSU Community Music School (517) 355-7661, ext. 16, adarche@msu.edu EAST LANSING, Mich. ­Michigan's past is the inspiration

Liu, Taosheng

152

Michigan State University | College of Engineering | Engineering Undergraduate Studies Engineering Building, 428 S. Shaw Lane, Room 1415, East Lansing MI 48824 | (517) 355-6616 ext. 1  

E-Print Network [OSTI]

Building, 428 S. Shaw Lane, Room 1415, East Lansing MI 48824 | (517) 355-6616 ext. 1 http 3 BE 481 Water Resources Sys Anlys & Modeling 3 BE 482 Diffuse-Source Pollution Engineering 3 CHE 450 International Environmental Law & Policy 3 ME 417 Design of Alternative Energy Systems 3 ME 422

153

HEAT BUMP MODELING IN HIGH HEAT-LOAD X-RAY OPTICS* E. Windisch IV, Wayne State, Detroit, MI, 48201, U.S.A.  

E-Print Network [OSTI]

HEAT BUMP MODELING IN HIGH HEAT-LOAD X-RAY OPTICS* E. Windisch IV, Wayne State, Detroit, MI, 48201, U.S.A. Abstract Thermal deformation in high heat load X-Ray optics limits coherence and reduces flux-equipped MATLAB program designed to calculate three dimensional energy depostion in a solid. It uses an executable

Cinabro, David

154

Modulation of North Pacific Tropical Cyclone Activity by Three Phases of ENSO HYE-MI KIM, PETER J. WEBSTER, AND JUDITH A. CURRY  

E-Print Network [OSTI]

Modulation of North Pacific Tropical Cyclone Activity by Three Phases of ENSO HYE-MI KIM, PETER J Pacific Ocean warming has been separated into two modes based on the spatial distribution of the maximum impacts on tropical cyclone (TC) activity over the North Pacific by differential modulation of both local

Webster, Peter J.

155

Rf : Munoz, M.I., Barcellini F., Mollo, V. (2011). Collective elaboration of care for safety in radiotherapy: cooperative management of patient variability. In HEPS'2011 Healthcare Ergonomics  

E-Print Network [OSTI]

in radiotherapy: cooperative management of patient variability. In HEPS'2011 Healthcare Ergonomics and Patient of patient variability. Maria Isabel Munoz Ergonomics Laboratory Research Center on work Development (CRTD-EA 4132) 41 rue Gay Lussac 75005 Paris mi.munoz@free.fr Flore Barcellini1 Ergonomics Laboratory Research

Paris-Sud XI, Université de

156

Experienced Irrigation Technician (Brighton, MI) Beauchamp Lawn Care and Landscape is a property maintenance and landscape company that has been in Livingston  

E-Print Network [OSTI]

maintenance and landscape company that has been in Livingston County for over 20 years. We are looking Care and Landscape is a property maintenance and landscape company that has been in Livingston County Technicians (Brighton, MI) Beauchamp Lawn Care and Landscape is a property maintenance and landscape company

Isaacs, Rufus

157

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia  

E-Print Network [OSTI]

The oncogenic transcription factor TAL1/SCL is aberrantly expressed in 60% of cases of human T cell acute lymphoblastic leukemia (T-ALL) and initiates T-ALL in mouse models. By performing global microRNA (miRNA) expression ...

Mansour, Marc R.

158

Arginine metabolism in enterocytes of diabetic rats  

E-Print Network [OSTI]

Diabetic rats and patients exhibit decreased plasma arginine concentrations. Arginine is important in numerous cellular pathways, including the synthesis of nitric oxide and the release of insulin from pancreatic ? cells. At present, little...

Morrow, Natalie Anne

2002-01-01T23:59:59.000Z

159

The Metabolism of Curium in the RAT  

E-Print Network [OSTI]

G. , "The Metabolism of Americium in the Rat", Jour. Clin.of the metabOlism of americium has been reported in.is also radloacti ve. Americium and curium are not available

Hamilton, J.

2010-01-01T23:59:59.000Z

160

Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern  

SciTech Connect (OSTI)

Highlights: •The oncogenic miR-17-5p is downregulated in non-metastatic hepatocellular carcinoma patients. •E2F-1 and c-MYC transcripts are upregulated in non-metastatic HCC patients. •miR-17-5p forced overexpression inhibited E2F-1 and c-MYC expression in HuH-7 cells. •miR-17-5p mimicking increased HuH-7 cell growth, proliferation, migration and colony formation. •miR-17-5p is responsible for HCC progression among the c-MYC/E2F-1/miR-17-5p triad members. -- Abstract: E2F-1, c-MYC, and miR-17-5p is a triad of two regulatory loops: a negative and a positive loop, where c-MYC induces the expression of E2F-1 that induces the expression of miR-17-5p which in turn reverses the expression of E2F-1 to close the loop. In this study, we investigated this triad for the first time in hepatocellular carcinoma (HCC), where miR-17-5p showed a significant down-regulation in 23 non-metastatic HCC biopsies compared to 10 healthy tissues; however, E2F-1 and c-MYC transcripts were markedly elevated. Forced over-expression of miR-17-5p in HuH-7 cells resulted in enhanced cell proliferation, growth, migration and clonogenicity with concomitant inhibition of E2F-1 and c-MYC transcripts expressions, while antagomirs of miR-17-5p reversed these events. In conclusion, this study revealed a unique pattern of expression for miR-17-5p in non-metastatic HCC patients in contrast to metastatic HCC patients. In addition we show that miR-17-5p is the key player among the triad that tumor growth and spread.

El Tayebi, H.M.; Omar, K.; Hegy, S.; El Maghrabi, M.; El Brolosy, M. [The Molecular Pathology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo (Egypt)] [The Molecular Pathology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo (Egypt); Hosny, K.A. [Department of General Surgery, Faculty of Medicine, Cairo University, Cairo (Egypt)] [Department of General Surgery, Faculty of Medicine, Cairo University, Cairo (Egypt); Esmat, G. [Department of Endemic Medicine and Hepatology, Cairo University, Cairo (Egypt)] [Department of Endemic Medicine and Hepatology, Cairo University, Cairo (Egypt); Abdelaziz, A.I., E-mail: ahmed.abdel-aziz@guc.edu.eg [The Molecular Pathology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo (Egypt)

2013-05-10T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

A study of muon neutrino disappearance with the MINOS detectors and the NuMI neutrino beam  

SciTech Connect (OSTI)

This thesis presents the results of an analysis of {nu}{sub {mu}} disappearance with the MINOS experiment, which studies the neutrino beam produced by the NuMI facility at Fermi National Accelerator Laboratory. The rates and energy spectra of charged current {nu}{sub {mu}} interactions are measured in two similar detectors, located at distances of 1 km and 735 km along the NuMI beamline. The Near Detector provides accurate measurements of the initial beam composition and energy, while the Far Detector is sensitive to the effects of neutrino oscillations. The analysis uses data collected between May 2005 and March 2007, corresponding to an exposure of 2.5 x 10{sup 20} protons on target. As part of the analysis, sophisticated software was developed to identify muon tracks in the detectors and to reconstruct muon kinematics. Events with reconstructed tracks were then analyzed using a multivariate technique to efficiently isolate a pure sample of charged current {nu}{sub {mu}} events. An extrapolation method was also developed, which produces accurate predictions of the Far Detector neutrino energy spectrum, based on data collected at the Near Detector. Finally, several techniques to improve the sensitivity of an oscillation measurement were implemented, and a full study of the systematic uncertainties was performed. Extrapolating from observations at the Near Detector, 733 {+-} 29 Far Detector events were expected in the absence of oscillations, but only 563 events were observed. This deficit in event rate corresponds to a significance of 4.3 standard deviations. The deficit is energy dependent and clear distortion of the Far Detector energy spectrum is observed. A maximum likelihood analysis, which fully accounts for systematic uncertainties, is used to determine the allowed regions for the oscillation parameters and identifies the best fit values as {Delta}m{sub 32}{sup 2} = 2.29{sub -0.14}{sup +0.14} x 10{sup -3} eV{sup 2} and sin{sup 2} 2{theta}{sub 23} > 0.953 (68% confidence level). The models of neutrino decoherence and decay are disfavored at the 5.0{sigma} and 3.2{sigma} levels respectively, while the no oscillation model is excluded at the 9.4{sigma} level.

Marshall, John Stuart; /Cambridge U.

2008-06-01T23:59:59.000Z

162

TRACTOGRAPHY OF FORNIX, CINGULUM, AND CORPUS CALLOSUM IN RAT BRAIN  

E-Print Network [OSTI]

was performed and visually inspected for anatomical correctness according to a rat atlas brain. Values of Trace as the effects of pharmacological drugs on white matter. DISCUSSION Figure 4: Trace, FA, RD, and AD Figure 1: Rat

163

The influence of magnesium deficiency on inflammatory reaction in rats  

E-Print Network [OSTI]

The influence of magnesium deficiency on inflammatory reaction in rats Régine DELAIGUE, P. DUCHENE, France. Summary. The inflammatory reactions obtained in magnesium-deficient rats, by injecting of inflammatory reactions observed in magnesium- deficient rats could not be explained only by histamine

Paris-Sud XI, Université de

164

Viability of adult rat skin following 13 Mev proton irradiation  

E-Print Network [OSTI]

then removed from suspension by centrifugation and washed twice in Smith's chick heart growth media. 33 All cells removed from the biopsy by this enzyme dissection were placed in culture to check viability. Two Rose chambers con- taining the first scraping... Dissipation . Diagram ? Proton Energy Dissipation 17 17 Cell Suspension Filter Tube. Exploded View of Rose Chamber 24 Rat 822, Gross Appearance 37 SB. Rat 822, Skin Section. 38 Rat 771, Gross Appearance 37 Rat 771, Skin Section. 38 7A. 7B. Rat 835...

Caraway, Bobby Lamar

1966-01-01T23:59:59.000Z

165

Approach to Recover Hydrocarbons from Currently Off-Limit Areas of the Antrim Formation, MI Using Low-Impact Technologies  

SciTech Connect (OSTI)

The goal of this project was to develop and execute a novel drilling and completion program in the Antrim Shale near the western shoreline of Northern Michigan. The target was the gas in the Lower Antrim Formation (Upper Devonian). Another goal was to see if drilling permits could be obtained from the Michigan DNR that would allow exploitation of reserves currently off-limits to exploration. This project met both of these goals: the DNR (Michigan Department of Natural Resources) issued permits that allow drilling the shallow subsurface for exploration and production. This project obtained drilling permits for the original demonstration well AG-A-MING 4-12 HD (API: 21-009-58153-0000) and AG-A-MING 4-12 HD1 (API: 21-009-58153-0100) as well as for similar Antrim wells in Benzie County, MI, the Colfax 3-28 HD and nearby Colfax 2-28 HD which were substituted for the AG-A-MING well. This project also developed successful techniques and strategies for producing the shallow gas. In addition to the project demonstration well over 20 wells have been drilled to date into the shallow Antrim as a result of this project's findings. Further, fracture stimulation has proven to be a vital step in improving the deliverability of wells to deem them commercial. Our initial plan was very simple; the 'J-well' design. We proposed to drill a vertical or slant well 30.48 meters (100 feet) below the glacial drift, set required casing, then angle back up to tap the resource lying between the base to the drift and the conventional vertical well. The 'J'-well design was tested at Mancelona Township in Antrim County in February of 2007 with the St. Mancelona 2-12 HD 3.

James Wood; William Quinlan

2008-09-30T23:59:59.000Z

166

Social Influences on Food Choices of Norway Rats and Mate Choices of Japanese Quail  

E-Print Network [OSTI]

ecology and sociology of the Norway rat . Bethesda: U.S. De-food stealing by young Norway rats. Journal of Comparativesufficient diet by Norway rats. Journal of Comparative

Galef, Jr., Bennett G.

2001-01-01T23:59:59.000Z

167

Demography of auklets Aethia spp. in relation to introduced Norway rats Rattus norvegicus at Kiska  

E-Print Network [OSTI]

Demography of auklets Aethia spp. in relation to introduced Norway rats Rattus norvegicus at Kiska................................................................................................4 Norway Rat Abundance and Distribution .........................................................5................................................................................................6 Norway Rat Abundance and Distribution.........................................................7

Jones, Ian L.

168

Dose Dependent Response to Cyclodextrin Infusion in a Rat Model of Verapamil Toxicity  

E-Print Network [OSTI]

Effect of cyclodextrin infusion in a rat model of verapamilresuscitation with a lipid infusion shifts the dose-responseResponse to Cyclodextrin Infusion in a Rat Model of

Mottram, Allan R.; Bryant, Sean M; Aks, Steven E

2012-01-01T23:59:59.000Z

169

E-Print Network 3.0 - adult rats effects Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in Norway rats and von Frisch's (1967) extraordinary demonstrations of social effects on food selection... observed that Norway rats born to a colony whose adults had learned to...

170

E-Print Network 3.0 - adult rat brain Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Image Analysis... Cytochem 44:981-987,19%) KEY WORDS: Immunohistochemistry; Image analysis; GABAAre- ceptor; Rat; Brain... density in postfixed thin sections of rat...

171

Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...

172

E-Print Network 3.0 - adult rat liver Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

from normal rat liver and incubated for 3 or 16 hours with increasing doses... of carbon tetrachloride (CCl4). Rat ... Source: Groningen, Rijksuniversiteit - Centre for...

173

Suppressed serum prolactin in sinoaortic-denervated rats  

SciTech Connect (OSTI)

The authors investigated the effect of arterial baroreceptor deafferentation on serum and pituitary prolactin (PRL) and on catecholamines in median eminence (ME) and anterior and posterior pituitaries. Male Wistar rats were sinoaortic denervated (SAD) or sham operated (SO). Three days after surgery serum prolactin, measured by radioimmunoassay, was suppressed in SAD rats, and dopamine (DA) and norepinephrine (NE) concentrations, measured by radioenzymatic or high-performance liquid chromatography electron capture methods, were significantly reduced in ME of SAD rats. Simultaneously, anterior pituitary of SAD rats had significant increases in both catecholamines, whereas posterior pituitary showed no changes. Four hours after surgery serum PRL was also reduced in SAD rats, but no changes in ME catecholamines were found. Mean arterial pressure (MAP) and heart rate were measured before and after injection of bromocriptine in SAD and SO rats 3 days after surgery. Bromocriptine markedly suppressed serum PRL in both groups and reduced MAP from 144 +/- 10 to 84 +/- 5 and from 116 +/- 2 to 99 +/- 3 in SAD and SO rats, respectively; heart rate was reduced in SAD rats. They conclude that the SAD rat is a model of hypertension with suppressed serum PRL and that interruption of arterial baroreceptor nerves suppresses PRL secretion probably by modulating tuberoinfundibular turnover of catecholamines.

Alexander, N.; Melmed, S.; Morris, M.

1987-02-01T23:59:59.000Z

174

adult rat vestibular: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

stimulate cell proliferation in adult rat vestibular sensory epithelia, as does the infusion of transforming growth factor alpha (TGF ) plus insulin. We sought to determine...

175

Uranium biokinetics in gavaged young adult female rats.  

E-Print Network [OSTI]

??Blood, liver, kidney, femur, and ovaries were assayed from female Wistar rats following oral administration of uranyl nitrate. Three uranium concentrations were studied for six… (more)

Keizer, Philip John

1986-01-01T23:59:59.000Z

176

Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo  

SciTech Connect (OSTI)

Human response to isoproterenol induced cardiac injury was evaluated by gene and protein pathway changes in human heart slices, and compared to rat heart slices and rat heart in vivo. Isoproterenol (10 and 100 ?M) altered human and rat heart slice markers of oxidative stress (ATP and GSH) at 24 h. In this in vivo rat study (0.5 mg/kg), serum troponin concentrations increased with lesion severity, minimal to mild necrosis at 24 and 48 h. In the rat and the human heart, isoproterenol altered pathways for apoptosis/necrosis, stress/energy, inflammation, and remodeling/fibrosis. The rat and human heart slices were in an apoptotic phase, while the in vivo rat heart exhibited necrosis histologically and further progression of tissue remodeling. In human heart slices genes for several heat shock 70 kD members were altered, indicative of stress to mitigate apoptosis. The stress response included alterations in energy utilization, fatty acid processing, and the up-regulation of inducible nitric oxide synthase, a marker of increased oxidative stress in both species. Inflammation markers linked with remodeling included IL-1?, Il-1?, IL-6 and TNF? in both species. Tissue remodeling changes in both species included increases in the TIMP proteins, inhibitors of matrix degradation, the gene/protein of IL-4 linked with cardiac fibrosis, and the gene Ccl7 a chemokine that induces collagen synthesis, and Reg3b a growth factor for cardiac repair. This study demonstrates that the initial human heart slice response to isoproterenol cardiac injury results in apoptosis, stress/energy status, inflammation and tissue remodeling at concentrations similar to that in rat heart slices. - Highlights: • Human response to isoproterenol induced cardiac injury evaluated in heart slices. • Isoproterenol altered apoptosis, energy, inflammation and remodeling pathways. • Human model verified by comparison to rat heart slices and rat heart in vivo. • Human and rat respond to isoproterenol at similar concentrations in vitro.

Herrmann, Julia E.; Heale, Jason; Bieraugel, Mike; Ramos, Meg [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine, CA 92612 (United States); Fisher, Robyn L. [Vitron Inc., Tucson, AZ (United States); Vickers, Alison E.M., E-mail: vickers_alison@allergan.com [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine, CA 92612 (United States)

2014-01-15T23:59:59.000Z

177

A DELAYED NONLINEAR PBPK MODEL FOR GENISTEIN DOSIMETRY IN RATS  

E-Print Network [OSTI]

A DELAYED NONLINEAR PBPK MODEL FOR GENISTEIN DOSIMETRY IN RATS #3; MICHAEL G. ZAGER y , HIEN T on laboratory animals and human volunteers [4], and critical literature reviews [32]. Phytoestrogens, a class endocrine-related e#11;ects such as reduced birth weight in rats and humans. In its conjugated form

178

Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska  

E-Print Network [OSTI]

Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska Island, Alaska-3239 FAX: (709) 737-3018 e-mail: x19hlm@mun.ca #12;Major and Jones Impacts of the Norway Rat... 2 Fresh rat during World War II (Atkinson, 1985). It is believed that the Norway Rat (Rattus norvegicus

Jones, Ian L.

179

Rat Trachea Dose Distribution Model Using MCNPTM  

E-Print Network [OSTI]

formed the trachea. The outer cylinder represented the outer part of the rat trachea with a radius of 0.1 cm, and the other cylinder, with a radius of 0.075 cm, represented the inner part of the trachea. The trachea was the volume that is not shared... tallies provided a more sound result for both the 22? and 45?calculations, as the calculated relative error was below 0.1 and, therefore is generally reliable by MCNP TM standards. However, neither of the *F8 tallies were below the 0.1 reference value...

Almanza, Christian

2010-01-15T23:59:59.000Z

180

Ultrastructural development of the rat corpus luteum  

E-Print Network [OSTI]

througn semi-micro dissection of the ovary, tissue differentation in some fields of view was d. ifficult and classification as to cell type was virtually impossible. By comparison of intracellular structure and. inclusions with the work of previous...hitehoiise q r ~ T stiiy y of tne ultr structu. "e of the d. velopin' corpus lu eum cells;ias carried out. The rats::ere sacrificed according to their st-, -. e of estrous, eiid their ovaries removed immediately before dicath. The tissue was fixed in 25...

Bailey, John Franklin

1971-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

1.Physics Department, Colorado School of Mines, Golden, CO 2. National Renewable Energy Laboratory, Golden, CO 3. United Solar Ovonic, LLC Troy, MI, United States THERMAL ACTIVATION OF DEEP OXYGEN DEFECT FORMATION AND HYDROGEN EFFUSION  

E-Print Network [OSTI]

1.Physics Department, Colorado School of Mines, Golden, CO 2. National Renewable Energy Laboratory, Golden, CO 3. United Solar Ovonic, LLC Troy, MI, United States BACKGROUND THERMAL ACTIVATION OF DEEP was partially supported by a DOE grant through United Solar Ovonics, Inc., under the Solar America Initiative

182

MicroRNA analysis of human embryonic stem cell derived cardiomyocytes and neonatal rat ventricular cardiomyocytes  

E-Print Network [OSTI]

infarction (M.I. ), or heart attack. What is most strikingformed as a result of a heart attack. This is due to thatcases such as in a heart attack remain unanswered. There are

Nelson, Brandon John

2007-01-01T23:59:59.000Z

183

AMPA-receptor mediated plasticity within the rat spinal cord  

E-Print Network [OSTI]

Previous research from our laboratory has demonstrated that the spinal cord is capable of a simple form of instrumental learning. In this instrumental learning paradigm, rats typically receive a complete spinal transection at the second thoracic...

Hoy, Kevin Corcoran

2009-05-15T23:59:59.000Z

184

adult rats rattus: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 IMPACTS OF INTRODUCED NORWAY RATS (RATTUS NORVEGICUS) ON LEAST AUKLETS (AETHIA PUSILLA) BREEDING AT KISKA ISLAND,...

185

Intracellular protein degradation in cultured rat muscle cells  

E-Print Network [OSTI]

1982 Major Subject: Biochemistry INTRACELLULAR PROTEIN DEGRADATION IN CULTURED RAT MUSCLE CELLS A Thesis by GWENDOLYN BETH MILLER Approved as to style and content by: hairman of Committee) p I 'P) (Member) (M r) (Head of Department) August... 1982 "BOGS-'. 4( 3 3q ABSTRACT Intracellular Protein Degradation in Cultured Rat Muscle Cells (August 1982) Gwendolyn Beth Miller, B. S. , Texas Asm Dniversity Chairman of Advisory Committee: Dr. J. martyn Gunn Intra:elMlar protein degradation...

Miller, Gwendolyn Beth

1982-01-01T23:59:59.000Z

186

Non-essential amino acid metabolism in rats  

E-Print Network [OSTI]

NON-ESSENTIAL AMINO ACID METABOLISM IN RATS A Thesis by JAMES DARRELL CROOKS, JR. Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE May 1971 Major Subject...: Animal Nutrition O 4 0 E ? NON ESSENTIAL AMINO ACID METABOLISM IN RATS A Thesis by JAMES DARRELL CROOKS& JR. Approved as to style and content by: (Chairman of Committee) (Member) (Head of Department) (Member) May 197 1 ABSTRACT Non...

Crooks, James Darrell

2012-06-07T23:59:59.000Z

187

Preexposure sensitizes rats to the reinforcing effects of cocaine  

E-Print Network [OSTI]

PREEXPOSURE SENSITIZES RATS TO THE REINFORCING EFFECTS OF COCAINE A Thesis by BRIAN ARTHUR HORGER Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE May 1990 Major Subject: Psychology PREEXPOSURE SENSITIZES RATS TO THE REINFORCING EFFECTS OF COCAINE A Thesis by BRIAN ARTHUR HORGER Approved as to style and content by: Susan Sch nk ' (Chair of Committee) ~, r, :. ). ~+~~- ?- : Jack R...

Horger, Brian Arthur

2012-06-07T23:59:59.000Z

188

Arginine and Conjugated Linoleic Acid Reduce Fat Mass in Rats  

E-Print Network [OSTI]

ARGININE AND CONJUGATED LINOLEIC ACID REDUCE FAT MASS IN RATS A Thesis by JENNIFER LYNN NALL Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE May 2008 Major Subject: Nutrition ARGININE AND CONJUGATED LINOLEIC ACID REDUCE FAT MASS IN RATS A Thesis by JENNIFER LYNN NALL Submitted to the Office of Graduate Studies Texas A...

Nall, Jennifer L.

2010-10-12T23:59:59.000Z

189

Neuroendocrine effects of acute nickel chloride administration in rats  

SciTech Connect (OSTI)

An sc injection of nickel chloride (20 and 10 mg/kg) led to a profound and consistent increase of circulating prolactin (PRL) levels after 1 day and lasted for 4 days (p < 0.001) in male rats. Increases in insulin levels occurred 1 and 2 days postinjection. The nickel-induced PRL rise could be abolished by a simultaneous administration of 2-bromo-..cap alpha..-ergocryptine (CB 154). In vitro incubation of pituitaries from rats that received 20 mg/kg of nickel chloride 48 hr prior to sacrifice released more PRL into the culture medium, as well as contained more PRL in the final tissue than did the pituitaries from control animals. The hypothalamic extracts (HE) obtained from hypothalami of nickel-injected rats were tested also in vitro on normal rat pituitaries and the results showed that the HE from such rats released more PRL and therefore had less prolactin-inhibiting factor (PIF) than the HE obtained from control rats. The results show that nickel chloride has effects on the endocrine system that (a) last considerably longer than previously reported, (b) are mediated through the neuroendocrine system, and (c) instead of specifically inhibiting PRL secretion from the pituitary promote high circulating PRL levels lasting from 1 to 4 days.

Clemons, G.K.; Garcia, J.F.

1981-01-01T23:59:59.000Z

190

Toxicologic and biochemical effects of extracts from Karwinskia humboldtiana on the albino rat  

E-Print Network [OSTI]

) received empty gelatin capsules once each week for seven weeks. Group IV-C contained six control rats, and these rats were not fed Ch-3. The treated rats in Group IV-A and the control rats in Group IV-C were fed Purina Rat Chow ad libitum throughout... the study. The treated animals in Group IV-A were individually killed by decapitation and necropsied when it appeared they were in a moribund condition. Rats in Groups IV-B and IV-C were killed and necropsied on the BBth day. Blood samples were collected...

Wheeler, Michael Hugh

1970-01-01T23:59:59.000Z

191

First 450-micron dust continuum mapping of the massive star-forming region NGC 3576 with the P-ArTeMiS bolometer camera  

E-Print Network [OSTI]

Context: The earliest phases of massive star formation are currently much debated. Aims. In an effort to make progress, we took a census of Class0-like protostellar dense cores in the NGC 3576 region, one of the nearest and most luminous embedded sites of high-mass star formation in the Galaxy. Methods: We used the P-ArTeMiS bolometer camera on the APEX telescope to produce the first 450-micron dust continuum map of the filamentary dense clump associated with NGC 3576. Results: Combining our 450-micron observations with existing data at other wavelengths, we have identified seven massive protostellar sources along the NGC 3576 filament and placed them in the M_env - L_bol evolutionary diagram for protostars. Conclusions: Comparison with theoretical evolutionary tracks suggests that these seven protostellar sources will evolve into massive stars with masses M* ~ 15-50 Msun. Four sources are classified as candidate high-mass Class 0 objects, two sources as massive Class I objects, and one source appears to be at an intermediate stage.

P. André; V. Minier; P. Gallais; V. Reveret; J. Le Pennec; L. Rodriguez; O. Boulade; E. Doumayrou; D. Dubreuil; M. Lortholary; J. Martignac; M. Talvard; C. De Breuck; G. Hamon; N. Schneider; S. Bontemps; P. O. Lagage; E. Pantin; H. Roussel; M. Miller; C. R. Purcell; T. Hill; J. Stutzki

2008-09-23T23:59:59.000Z

192

E-Print Network 3.0 - awake behaving rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

rats Search Powered by Explorit Topic List Advanced Search Sample search results for: awake behaving rats Page: << < 1 2 3 4 5 > >> 1 Stimulus-driven response dynamics of the...

193

E-Print Network 3.0 - adult rat central Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

194

E-Print Network 3.0 - adult rat posterodorsal Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

195

E-Print Network 3.0 - adult rats relate Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

196

E-Print Network 3.0 - adult rats exposed Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

197

E-Print Network 3.0 - adult rat offspring Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

198

E-Print Network 3.0 - adult rats tested Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

199

E-Print Network 3.0 - adult rats potential Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

200

E-Print Network 3.0 - adult rats relationship Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

E-Print Network 3.0 - adult rats efeito Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

202

E-Print Network 3.0 - adult rats treated Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

203

E-Print Network 3.0 - adult rat type Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

204

E-Print Network 3.0 - acid-deficient hairless rat Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

with hairless rat skin mounted... of the gel was made by contact with a Kodak BioMax MR film (France). Animals Female hairless rats (OFA... as to obtain 20 mg b-lactoglobulin per...

205

E-Print Network 3.0 - adult rat pancreas Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

-expressing vector as 5 doses between 27 and 39 h after the first dose of HGF into young adult rats (data not shown... , Thyroid, Spleen, and Colon in Rats in Vivo Cuihua ......

206

Circadian rhythms on hypothalamicpituitaryadrenal axis hormones and cytokines of collagen induced arthritis in rats  

E-Print Network [OSTI]

with corresponding circadian fluctuations in cytokines in a rat model of collagen-induced arthritis (CIA). CIA adjuvant at the left foot. On day 33, in both the CIA and the control rats, circulating adrenocorticotropin-rhythmometry. The results showed that plasma corticosterone in CIA rats had a trough at 18:00 and reached a peak at 06

Li, Shao

207

Assessing the effects of Norway rats on auklet breeding success and survival at Sirius Point, Kiska  

E-Print Network [OSTI]

Assessing the effects of Norway rats on auklet breeding success and survival at Sirius Point, Kiska Introduction The presence of introduced Norway rats (Rattus norvegicus) has been implicated as a possible sightings of Norway rats at Sirius Point Colony during the late 1980s and early 1990s. Furthermore

Jones, Ian L.

208

Marine Ornithology 41: 4148 (2013) Bond et al.: Crested Auklet survival with Norway Rats 41  

E-Print Network [OSTI]

Marine Ornithology 41: 41­48 (2013) Bond et al.: Crested Auklet survival with Norway Rats 41 in the Aleutians (Bailey 1993, Ebbert & Byrd 2002). Another introduced predator, the Norway rat Rattus norvegicus AND REPRODUCTIVE SUCCESS OF CRESTED AUKLETS AETHIA CRISTATELLA IN THE PRESENCE OF INTRODUCED NORWAY RATS RATTUS

Jones, Ian L.

209

Variations in the diet of introduced Norway rats (Rattus norvegicus) inferred using stable isotope analysis  

E-Print Network [OSTI]

Variations in the diet of introduced Norway rats (Rattus norvegicus) inferred using stable isotope predators; island ecosystem conservation; stable isotope analysis; Norway rats; diet. Correspondence Heather of introduced Norway rats Rattus norvegicus has raised concerns for the fate of the large least auklet Aethia

Jones, Ian L.

210

Stimulus Control of Maternal Responsiveness to Norway Rat (Rattus norvegicus) Pup Ultrasonic Vocalizations  

E-Print Network [OSTI]

Stimulus Control of Maternal Responsiveness to Norway Rat (Rattus norvegicus) Pup Ultrasonic be considered a specialization of Norway rats and other small rodents. When removed from the nest and placed in a cool environment, infant Norway rats emit USVs. These vocalizations range from 30 to 50 k

211

Serum proteins in magnesium-deficient rat Y. RAYSSIGUIER P. LARVOR Y. AUGUSTI J. DURLACH  

E-Print Network [OSTI]

Serum proteins in magnesium-deficient rat Y. RAYSSIGUIER P. LARVOR Y. AUGUSTI J. DURLACH (1 Cochin, Paris Summary. Hypoproteinemia appears early in the magnesium-deficient rat with a drop in serum. In the magnesium-deficient rat, we have shown serum protein modifications related to immunologic and allergic

Paris-Sud XI, Université de

212

Dietary L-arginine supplementation reduces fat mass in diet-induced obese rats  

E-Print Network [OSTI]

This study was conducted to test the hypothesis that dietary arginine supplementation reduces fat mass in diet-induced obese rats. Male Sprague-Dawley rats were fed either low- or high-fat diets for 15 wks (16 rats/diet). Thereafter, lean or obese...

Jobgen, Wenjuan Shi

2009-06-02T23:59:59.000Z

213

E-Print Network 3.0 - aging female rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

DAMAGE POTENTIAL OF THREE RODENT SPECIES ON Summary: : 0.39 0.03g; female cotton rats: 0.34 0.03g; male roof rats:0.25 0.04g; female roof rats:0... .26 0.04g;...

214

Inhalation developmental toxicology studies: Acetonitrile in rats. Final report  

SciTech Connect (OSTI)

The potential for acetonitrile to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 100, 400, or 1200 ppM acetonitrile, 6 hours/day, 7 days/week. Exposure of rats to these concentrations of acetonitrile resulted in mortality in the 1200 ppM group (2/33 pregnant females; 1/10 non-pregnant females). However, there were no treatment-related effects upon body weights or reproduction indices at any exposure level, nor was there a significant increase in the incidence of fetal malformations or variations. The only effect observed in the fetuses was a slight, but not statiscally significant, exposure-correlated increase in the incidence of supernumerary ribs. Determination of acetonitrile and cyanide concentrations in maternal rat blood showed that acetonitrile concentration in the blood increased with exposure concentration for all exposed maternal rats. Detectable amounts of cyanide in the blood were found only in the rats exposed to 1200 ppM acetonitrile ({approximately}2 {mu}g cyanide/g of blood).

Mast, T.J.; Weigel, R.J.; Westerberg, R.B.; Boyd, P.J.; Hayden, B.K.; Evanoff, J.J.; Rommereim, R.L.

1994-02-01T23:59:59.000Z

215

Sexual differences in the expression of copper deficiency in rats  

SciTech Connect (OSTI)

The present investigation was undertaken to establish whether the severity of copper deficiency in rats fed diets containing fructose is affected by the presence and type of endogenous sex hormones. Intact and castrated male rats and intact and ovariectomized females were fed from weaning a copper-deficient diet (0.6 ppm) containing 62% fructose for 8 weeks. Regardless of castration, male rats were anemic, exhibited heart hypertrophy, and died of the deficiency. However, castration ameliorated the anemia and delayed the mortality. In contrast, none of the females died of the deficiency. It is suggested that in addition to the sex of the animal, levels of testosterone in the male may also play a role in the severity of copper deficiency.

Fields, M.; Lewis, C.G.; Beal, T.; Scholfield, D.; Patterson, K.; Smith, J.C.; Reiser, S.

1987-11-01T23:59:59.000Z

216

The laboratory rat strains most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia  

E-Print Network [OSTI]

and the nude rat. Uses Despite the fear that rats invoke in people they actually make quiet, gentle pets rate 70-115 Food consumption 5-6g/100g/d Water consumption 10-12ml/100g/d Breeding onset Male 65-110d

Shihadeh, Alan

217

Regional neurohypophysial and hypothalamic blood flow in rats during hypercapnia  

SciTech Connect (OSTI)

Regional cerebral blood flow (rCBF) was measured in the neurohypophysis and hypothalamus in normocapnic and hypercapnic rats using (/sup 14/C)isopropyliodoamphetamine. Rats were surgically prepared using nitrous oxide and halothane and placed in plaster restraining casts. Hypercapnia was produced by increasing the fractional concentration of inspired CO/sub 2/ (FICO/sub 2/). rCBF in normocapnic rats was higher in the paraventricular nucleus, supraoptic nucleus, median eminence, and neural lobe than rates previously measured by use of diffusible tracers. During hypercapnia blood flow increased linearly with arterial PCO/sub 2/ (PACO/sub 2/) in all regions except the median eminence and neural lobe, which were not affected by hypercapnia. When rats were pretreated with phentolamine (1 mg/kg) to block the alpha-adrenergic receptors, blood flow in the median eminence and neural lobe increased significantly during hypercapnia. We conclude that blood flow in the cell bodies of the paraventricular nucleus and supraoptic nucleus is regulated differently during hypercapnia than blood flow in the nerve terminals in the median eminence and neural lobe. Furthermore, vasodilation produced by increased CO/sub 2/ is offset by alpha-receptor stimulation in the median eminence and neural lobe.

Bryan, R.M. Jr.; Myers, C.L.; Page, R.B.

1988-08-01T23:59:59.000Z

218

Characterization of a plasma membrane zinc transporter in rat brain  

E-Print Network [OSTI]

Ireland Ltd. Keywords: Ion transport; Membrane vesicles; Excitotoxicity; Zinc homeostasis; TransitionCharacterization of a plasma membrane zinc transporter in rat brain Robert A. Colvin* Department transport in the brain. This report provides convincing evidence of a zinc transporter in plasma membrane

219

PROTECTIVE EFFECTS OF VERAPAMIL AGAINST HEXACHLOROBUTADIENE NEPHROTOXICITY IN RATS  

E-Print Network [OSTI]

In order to evaluate the protective effect of verapamil against hexachlorobutadiene (HCBD) nephrotoxicity, 30 adult Wistar albino rats were divided into five equal groups, A, B, C, D and E and were given intra-peritonially corn oil (I ml/kg; control), HCBD (50 mg/kg), verapamil (50 µg/kg) with HCBD

E. Moghtadai Khorasgani; K. Manochehri; M. Hosseini

220

Hypoxia Stimulates Vesicular ATP Release From Rat Osteoblasts  

E-Print Network [OSTI]

Hypoxia Stimulates Vesicular ATP Release From Rat Osteoblasts ISABEL R. ORRISS,1 GILLIAN E. KNIGHT, University of Surrey, Guildford, UK Many neuronal and non-neuronal cell types release ATP in a controlled manner. After release, extracellular ATP (or, following hydrolysis, ADP) acts on cells in a paracrine

Burnstock, Geoffrey

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Single Glucose Biofuel Cells Implanted in Rats Power Electronic Devices  

E-Print Network [OSTI]

Single Glucose Biofuel Cells Implanted in Rats Power Electronic Devices A. Zebda1,2 , S. Cosnier1 the first implanted glucose biofuel cell (GBFC) that is capable of generating sufficient power from a mammal further developments. Following recent developments in nano- and biotechnology, state-of-the-art biofuel

Boyer, Edmond

222

Susceptibility of immature rats to seizures induced by unsymmetrical dimethylhydrazine  

E-Print Network [OSTI]

. Bain. Convulsant hydrazides I. In vito and in vivo inhibition of vitamin B6 enzymes by convulsive hydrazides. J. Pharmacol. Exp. Ther. 119:255-262 (1957). 8. Baxter, C. F. , and E. Roberts. Elevation of gamma-aminobutyric acid in rat brain...

Boyd, Dale Duaine

1963-01-01T23:59:59.000Z

223

Original article Digestion and fermentation of proteins in rats fed  

E-Print Network [OSTI]

Original article Digestion and fermentation of proteins in rats fed keratin, albumin, cooked casein the hypothesis that cooking reduces the digestibility of casein, and increases the yield of bacterial me transfer and fermentation in the caecum. The caecal digestion of casein (cooked or not), ker- atin

Boyer, Edmond

224

Facial Wiping in the Rat Fetus: Variation of Chemosensory  

E-Print Network [OSTI]

how variation in stimulus parameters of lemon odor infusion (concentration, volume, and infusion time) affected the wiping response of E20 rat fetuses. Infusions of higher concentration or greater volume of stimulation. Intraoral infusion of chemosensory fluids with strong olfactory components, such as lemon extract

Robinson, Scott R.

225

Aardvark hunt in Kenya Gaten B. Rat}rUin  

E-Print Network [OSTI]

I I i Aardvark hunt in Kenya Gaten B. Rat}rUin Dept of Omittrologr & Mamrnalogr, Catifomia Academy eactrirg science as a Peace Corps Volunteer at Mirogi $conOary Scnou in Sou*r Nyanza District or Kenya of Kenya in Nairobi. 14 #12;

226

US ENC MI Site Consumption  

Gasoline and Diesel Fuel Update (EIA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines About U.S. NaturalA. Michael SchaalNovember 26,8,CoalThousandIL Site Consumption

227

Characterization and Mapping of the Gene Conferring Resistance to Rift Valley Fever Virus Hepatic Disease in WF.LEW Rats  

E-Print Network [OSTI]

168 271 164 218 243 142 154 268 168 271 164 218 243 142 D6Rat46 D6Rat68 D6Rat105 D6Rat74 D6Rat144 D6Rat135 D6Rat124 D6Rat116 D6Rat1 155 278 246 253 185 169 260 152 238 155 278 244 255 181 169 260... 220 242 181 349 134 177 256 132 131 160 165 216 242 181 349 134 177 256 132 133 148 159 220 248 203 349 126 175 246 138 171 160 163 214 248 203 349 126 175 246 138 171 160 163 214 248 203 349...

Callicott, Ralph J.

2010-01-14T23:59:59.000Z

228

Hemodynamic characterization of chronic bile duct-ligated rats: effect of pentobarbital sodium  

SciTech Connect (OSTI)

Systemic and splanchnic hemodynamics of the chronic bile duct-ligated rat were characterized by radioactive microspheres. Conscious and pentobarbital sodium-anesthetized, bile duct-ligated and sham-operated rats had cardiac output and regional organ blood flows determined. The conscious bile duct-ligated rat compared with the sham-operated showed a hyperdynamic circulation with an increased cardiac output and portal tributary blood flow. Pentobarbital sodium anesthesia induced marked hemodynamic changes in both sham-operated and bile duct-ligated rats. The latter group was especially sensitive to its effects; thus, comparison of cardiac output and portal tributary blood flow between anesthetized bile duct-ligated and sham-operated rats showed no significant differences. The authors conclude that the rat with cirrhosis due to chronic bile duct ligation is an excellent model for hemodynamic investigations but should be studied in the conscious state, since pentobarbital sodium anesthesia eliminated the hyperdynamic circulation.

Lee, S.S.; Girod, C.; Braillon, A.; Hadengue, A.; Lebrec, D.

1986-08-01T23:59:59.000Z

229

E-Print Network 3.0 - african mole rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

18 Trees of the "Madsen" data set Morphological topology Summary: Rat Capybara Rabbit Elephant Shrew Hedgehog Mole Sloth Opossum Kangaroo 12;Mitochondrial topology... Hedgehog...

230

Brain reward deficits accompany withdrawal (hangover) from acute ethanol in rats  

E-Print Network [OSTI]

stimulation reward: effects of ethanol. Alcohol Clin Exp Resstimulus produced by ethanol withdrawal. J Pharmacol Expthe "anxiogenic" response to ethanol withdrawal in the rat.

Schulteis, Gery; Liu, Jian

2006-01-01T23:59:59.000Z

231

E-Print Network 3.0 - aged rat vocal Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Medicine 96 SOCIAL LEARNING IN NON-PRIMATE MAMMALS Bennett G. Galef Summary: , elephants, food choice, hamsters, mate choice, meekats, poison avoidance, predator avoidance, rats......

232

E-Print Network 3.0 - adult rat prefrontal Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mem. Summary: of prefrontal neural activity in the rat to the acquisition of trace fear conditioning using microinfusions... was performed on a total of 120 adult male...

233

E-Print Network 3.0 - alloxan-treated rats beneficial Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in a panel of 11 different inbred rat strains to evaluate the genetic variance Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

234

E-Print Network 3.0 - adult rats neuroprotection Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

magnocellular nucleus basalis: neuroprotection by Ca(2... levels in rats: effects on brain 5-HT1A receptors and behavioral coping with stress in adult offspring... in adult...

235

E-Print Network 3.0 - awake rats achieving Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

<< < 1 2 3 4 5 > >> 1 Anticorrelated resting-state functional connectivity in awake rat brain Zhifeng Liang, Jean King, Nanyin Zhang Summary: Anticorrelated resting-state...

236

Sorbitol accumulation in male and female rats consuming starch or fructose diets with or without copper  

SciTech Connect (OSTI)

The present study was designed to examine the relationship between the sex of the rats, tissue sorbitol accumulation and copper deficiency in rats consuming dietary fructose. Rats were provided with a diet containing either 62.7% fructose or starch, and either 6.0 or 0.6 {mu}g copper/g for three weeks. Hepatic copper concentration of all rats consuming the copper-deficient diets was about 40% of copper sufficient rats. Hepatic, renal and thymic sorbitol concentrations were significantly elevated in males consuming the fructose, copper-deficient diet when compared to all other dietary groups regardless of the sex of the rat. Hepatic, renal the thymic fructose concentrations were significantly higher in rats eating fructose as compared to female rats. Hepatic glucose concentration was higher in males and females consuming the fructose, copper-deficient diet when compared to all other dietary groups. Renal glucose concentration was elevated in males as compared to females. These results demonstrate that the pathology and complications of copper deficiency in the male rat consuming fructose closely parallel aberration in tissue sorbitol accumulation.

Lewis, C.G.; Fields, M.; Beal, T. (Dept. of Agriculture, Beltsville, MD (USA))

1989-02-09T23:59:59.000Z

237

PyRAT - python radiography analysis tool (u)  

SciTech Connect (OSTI)

PyRAT is a radiography analysis tool used to reconstruction images of unknown 1-0 objects. The tool is written in Python and developed for use on LINUX and Windows platforms. The tool is capable of performing nonlinear inversions of the images with minimal manual interaction in the optimization process. The tool utilizes the NOMAD mixed variable optimization tool to perform the optimization.

Temple, Brian A [Los Alamos National Laboratory; Buescher, Kevin L [Los Alamos National Laboratory; Armstrong, Jerawan C [Los Alamos National Laboratory

2011-01-14T23:59:59.000Z

238

Integrated transcriptomic and proteomic evaluation of gentamicin nephrotoxicity in rats  

SciTech Connect (OSTI)

Gentamicin is an aminoglycoside antibiotic, which induces renal tubular necrosis in rats. In the context of the European InnoMed PredTox project, transcriptomic and proteomic studies were performed to provide new insights into the molecular mechanisms of gentamicin-induced nephrotoxicity. Male Wistar rats were treated with 25 and 75 mg/kg/day subcutaneously for 1, 3 and 14 days. Histopathology observations showed mild tubular degeneration/necrosis and regeneration and moderate mononuclear cell infiltrate after long-term treatment. Transcriptomic data indicated a strong treatment-related gene expression modulation in kidney and blood cells at the high dose after 14 days of treatment, with the regulation of 463 and 3241 genes, respectively. Of note, the induction of NF-kappa B pathway via the p38 MAPK cascade in the kidney, together with the activation of T-cell receptor signaling in blood cells were suggestive of inflammatory processes in relation with the recruitment of mononuclear cells in the kidney. Proteomic results showed a regulation of 163 proteins in kidney at the high dose after 14 days of treatment. These protein modulations were suggestive of a mitochondrial dysfunction with impairment of cellular energy production, induction of oxidative stress, an effect on protein biosynthesis and on cellular assembly and organization. Proteomic results also provided clues for potential nephrotoxicity biomarkers such as AGAT and PRBP4 which were strongly modulated in the kidney. Transcriptomic and proteomic data turned out to be complementary and their integration gave a more comprehensive insight into the putative mode of nephrotoxicity of gentamicin which was in accordance with histopathological findings. -- Highlights: ? Gentamicin induces renal tubular necrosis in rats. ? The mechanisms of gentamicin nephrotoxicity remain still elusive. ? Transcriptomic and proteomic analyses were performed to study this toxicity in rats. ? Transcriptomic and proteomic data turned out to be complementary and are integrated. ? A more comprehensive putative model of nephrotoxicity of gentamicin is presented.

Com, Emmanuelle, E-mail: emmanuelle.com@univ-rennes1.fr [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France) [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France); INSERM U625, Proteomics Core Facility Biogenouest, Rennes (France); Boitier, Eric; Marchandeau, Jean-Pierre [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France)] [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France); Brandenburg, Arnd [Genedata AG, Basel (Switzerland)] [Genedata AG, Basel (Switzerland); Schroeder, Susanne [Nycomed GmbH, Barsbüttel (Germany)] [Nycomed GmbH, Barsbüttel (Germany); Hoffmann, Dana; Mally, Angela [University of Würzburg, Department of Toxicology, University of Würzburg, Würzburg (Germany)] [University of Würzburg, Department of Toxicology, University of Würzburg, Würzburg (Germany); Gautier, Jean-Charles [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France)] [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France)

2012-01-01T23:59:59.000Z

239

Bitumen fume-induced gene expression profile in rat lung  

SciTech Connect (OSTI)

Exposure to bitumen fumes during paving and roofing activities may represent an occupational health risk. To date, most of the studies performed on the biological effect of asphalt fumes have been done with regard to their content in carcinogenic polycyclic aromatic hydrocarbons (PAH). In order to gain an additional insight into the mechanisms of action of bitumen fumes, we studied their pulmonary effects in rodents following inhalation using the microarray technology. Fisher 344 rats were exposed for 5 days, 6 h/day to bitumen fumes generated at road paving temperature (170 {sup o}C) using a nose-only exposition device. With the intention of studying the early transcriptional events induced by asphalt fumes, lung tissues were collected immediately following exposure and gene expression profiles in control and exposed rats were determined by using oligonucleotide microarrays. Data analysis revealed that genes involved in lung inflammatory response as well as genes associated with PAH metabolization and detoxification were highly expressed in bitumen-exposed animals. In addition, the expression of genes related to elastase activity and its inhibition which are associated with emphysema was also modulated. More interestingly genes coding for monoamine oxidases A and B involved in the metabolism of neurotransmitters and xenobiotics were downregulated in exposed rats. Altogether, these data give additional information concerning the bitumen fumes biological effects and would allow to better review the health effects of occupational asphalt fumes exposure.

Gate, Laurent [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France)]. E-mail: laurent.gate@inrs.fr; Langlais, Cristina [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Micillino, Jean-Claude [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Nunge, Herve [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Bottin, Marie-Claire [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Wrobel, Richard [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Binet, Stephane [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France)

2006-08-15T23:59:59.000Z

240

Albumin extravasation rates in tissues of anesthetized and unanesthetized rats  

SciTech Connect (OSTI)

Bovine serum albumin (BSA) labeled with /sup 131/I was injected intravenously in chronically prepared, unanesthetized rats and into pentobarbital-anesthetized rats that had received 2 ml 5% BSA to help sustain plasma volume. Initial uptake rates (clearances) in skin, skeletal muscles, diaphragm, and heart (left ventricle) were measured over 1 h. BSA labeled with /sup 125/I was injected terminally to correct for intravascular /sup 131/I-BSA. Observed clearances were in the following order in both groups of animals: heart much greater than diaphragm approximately equal to skin greater than resting skeletal muscles. Differences between unanesthetized and anesthetized animals were small and inconsistently directed. Our results suggest that the lower albumin clearances reported in the literature for anesthetized rats are not the result of their immobility or any direct effect of anesthesia on albumin transport in these tissues. The lower transport rates appear to result indirectly from changes produced by anesthesia and/or surgery in controllable parameters such as plasma volume and intravascular protein mass.

Renkin, E.M.; Joyner, W.L.; Gustafson-Sgro, M.; Plopper, G.; Sibley, L.

1989-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska Island, Alaska in 2003  

E-Print Network [OSTI]

Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska Island, Alaska of the Norway rat (Rattus norvegicus) onto Kiska Island, Aleutian Islands, Alaska, in the 1940s (Murie 1959 and to investigate the biology and demography of the Norway rat population. Moors and Atkinson (1984) suggested

Jones, Ian L.

242

Auklet Demography and the Influence of Norway rats at Kiska Island report on results of monitoring to 2009  

E-Print Network [OSTI]

Auklet Demography and the Influence of Norway rats at Kiska Island ­ report on results METHODS 4 AUKLET PRODUCTIVITY 4 TIMING OF BREEDING 5 AUKLET SURVIVAL 6 NORWAY RAT ABUNDANCE 10 NORWAY RAT ABUNDANCE AND DISTRIBUTION 10 VEGETATION CHANGES 11 DISCUSSION 11 LEAST AUKLET

Jones, Ian L.

243

Maternal Responsiveness to Infant Norway Rat (Rattus norvegicus) Ultrasonic Vocalizations During the Maternal Behavior Cycle and After  

E-Print Network [OSTI]

Maternal Responsiveness to Infant Norway Rat (Rattus norvegicus) Ultrasonic Vocalizations During environment, Norway rat (Rattus norvegicus) pups emit ultrasonic vocalizations that can elicit maternal search is particularly important in altricial species such as the Norway rat in which infants rely on the mother

244

ECOLOGY OF NORWAY RATS (RATTUS NORVEGICUS) IN RELATION TO CONSERVATION AND MANAGEMENT OF SEABIRDS ON KISKA ISLAND,  

E-Print Network [OSTI]

ECOLOGY OF NORWAY RATS (RATTUS NORVEGICUS) IN RELATION TO CONSERVATION AND MANAGEMENT OF SEABIRDS to predation by introduced Norway rats (Rattus norvegicus). In 2001 and 2002 the auklet colony experienced the lowest reproductive success ever recorded for auklets. Norway rats have been suggested as the cause

Jones, Ian L.

245

pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons  

E-Print Network [OSTI]

pH dependence and compartmentalization of zinc transported across plasma membrane of rat corticalH dependence and compartmental- ization of zinc transported across plasma membrane of rat cortical neurons. Am; ion transport; transition elements; primary culture IT IS KNOWN THAT Zn2 can enter neurons by two

246

Water balance in rats exposed to chronic centrifugation RUDY M. ORTIZ AND CHARLES E. WADE  

E-Print Network [OSTI]

was observed, the lack of a change in %TBW among the three measurement periods or in water flux over the 12Water balance in rats exposed to chronic centrifugation RUDY M. ORTIZ AND CHARLES E. WADE Life; accepted in final form 22 February 2000 Ortiz, Rudy M., and Charles E. Wade. Water balance in rats exposed

Ortiz, Rudy M.

247

The impact of binge drinking on the young growing female rat skeleton  

E-Print Network [OSTI]

, on the actively growing skeleton. The objective of this study was to determine whether or not binge drinking impacts the normal growth process of the young growing female rat skeleton. Twelve, four-week-old, female rats were paired to form an ethanol group and a...

Gallagher, Sharon Lee

1997-01-01T23:59:59.000Z

248

DRD2 Gene Transfer Into the Nucleus Accumbens Core of the Alcohol Preferring and Nonpreferring Rats  

E-Print Network [OSTI]

in alcohol intake in Sprague Dawley rats. This overexpression of DRD2 reduced alcohol consumption in a two that high levels of DRD2 are causally associated with a reduction in alcohol consumption and may serve Tomography (PET) Gene Therapy. ETHANOL STIMULATES BOTH dopamine (DA) neurons and DA release in the rat

Homes, Christopher C.

249

Research Report Effects of ethanol consumption by adult female rats on subsequent  

E-Print Network [OSTI]

Research Report Effects of ethanol consumption by adult female rats on subsequent consumption January 2004 Abstract We used a two-bottle choice test to measure voluntary ethanol consumption by adolescent rats that had lived with ethanol-consuming or water-consuming adult conspecifics. We found

Galef Jr., Bennett G.

250

PMSG responsiveness during adult life after partial oogonia destruction with misulban in the rat embryo  

E-Print Network [OSTI]

sensitive to X-ray irradiation in the last period of division, i.e. about day 15 of pregnancy in the rat-month old female rats were bred under standard conditions of light (14 h light―10 h dark) and food

Paris-Sud XI, Université de

251

MAGNESIUM ABSORPTION IN THE CCUM OF RATS RELATED TO VOLATILE FATTY ACIDS PRODUCTION  

E-Print Network [OSTI]

MAGNESIUM ABSORPTION IN THE C�CUM OF RATS RELATED TO VOLATILE FATTY ACIDS PRODUCTION Y. RAYSSIGUIER RELATIONS ENTRE L'ABSORPTION C,4ECALE DE MAGNESIUM CHEZ LE RAT ET LA PRODUCTION D'ACIDES GRAS VOLATILS du caecum, pH, acides gras volatils, activité microbienne. Introduction The mode of magnesium

Paris-Sud XI, Université de

252

Plasticity in the Rat Posterior Auditory Field Following Nucleus Basalis Stimulation  

E-Print Network [OSTI]

Plasticity in the Rat Posterior Auditory Field Following Nucleus Basalis Stimulation Amanda C. Plasticity in the rat posterior auditory field following nucleus basalis stimulation. J Neurophysiol 98: 253 have been shown to cause frequency-specific plasticity in both primary and secondary cortical areas

Kilgard, Michael P.

253

Activation of orexin signal in basal forebrain facilitates the emergence from sevoflurane anesthesia in rat  

E-Print Network [OSTI]

anesthesia in rat Hailong Dong 1 , Jiyuan Niu 1 , Binxiao Su, Zhenghua Zhu, Yan Lv, Yizhi Li, Lize Xiong t Orexinergic system may play an important role in the regulation of anesthesia­arousal. However, which region, induction and emergence time to sevoflurane anesthesia in rats. Either orexin-A or orexin-B was injected

254

Relaxation Time Constants and Apparent Diffusion Coefficients of Rat Retina at 7 Tesla  

E-Print Network [OSTI]

Relaxation Time Constants and Apparent Diffusion Coefficients of Rat Retina at 7 Tesla Govind Nair* and ADC of the rat eyes were measured at 50 3 50 3 800 lm at 7 Tesla. Profiles of T1, T2, T2* and ADC

Duong, Timothy Q.

255

Catheterization of the Hepatic Artery Via the Left Common Carotid Artery in Rats  

SciTech Connect (OSTI)

The commonly used approach for rat hepatic artery catheterization is via the gastroduodenal artery, which is ligated after the procedure. A new method of rat hepatic artery catheterization via the left common carotid artery (LCCA) is described. The LCCA is repaired after catheterization. The catheterization procedures included the following: (1) opening the rat's abdominal cavity and exposing the portion of abdominal aorta at the level of the celiac trunk; (2) separating and exposing the LCCA; inserting a microguidewire and microcatheter set into the LCCA via an incision; after placement into the descending aorta, the microguidewire and microcatheter are maneuvered into the hepatic artery under direct vision; (3) after transcatheter therapy, the catheter is withdrawn and the incision at the LCCA is repaired. This technique was employed on 60 male Sprague-Dawley rats with diethylnitrosamine-induced liver cancer, using a 3F microguidewire and microcatheter set. Selective hepatic artery catheterization was successfully performed in 57 rats. One rat died during the operation and five rats died within 7 days after the procedure. It is envisaged that as experience increases, the catheterization success rate will increase and the death rate will decrease. A new approach for selective hepatic artery catheterization via the LCCA in rats is introduced, which makes repeat catheterization of this artery possible and allows large embolization particles to be delivered by using a 3F catheter.

Li Xiao [West China Hospital, Sichuan University, Department of Radiology (China); Wang Yixiang, J. [AstraZeneca R and D (United Kingdom); Zhou Xiangping [West China Hospital, Sichuan University, Department of Radiology (China)], E-mail: xiangpingzhou46@163.com; Guan Yongsong; Tang Chengwei [West China Hospital, Sichuan University, Department of Gastroenterology (China)

2006-12-15T23:59:59.000Z

256

Nutrition & Food Science, 3009 Science Hall, Wayne State University, Detroit, MI 48202Telephone: (313) 577-2500 Fax: (313) 577-8616 Email: ab8207@wayne.edu World Wide Web: www.clas.wayne.edu/nfs (revised brochure Sep 2012)  

E-Print Network [OSTI]

.A.) are offered. The MA degree can have an emphasis in Food Service Management or be done in conjunction to be in non-laboratory aspects of nutrition or food service. Required Component of Courses: (13 credit hours & Food Science, 3009 Science Hall, Wayne State University, Detroit, MI 48202Telephone: (313) 577-2500 Fax

Berdichevsky, Victor

257

Proteomic analysis of rat cerebral cortex following subchronic acrolein toxicity  

SciTech Connect (OSTI)

Acrolein, a member of reactive ?,?-unsaturated aldehydes, is a major environmental pollutant. Acrolein is also produced endogenously as a toxic by-product of lipid peroxidation. Because of high reactivity, acrolein may mediate oxidative damages to cells and tissues. It has been shown to be involved in a wide variety of pathological states including pulmonary, atherosclerosis and neurodegenerative diseases. In this study we employed proteomics approach to investigate the effects of subchronic oral exposures to 3 mg/kg of acrolein on protein expression profile in the brain of rats. Moreover effects of acrolein on malondialdehyde (MDA) levels and reduced glutathione (GSH) content were investigated. Our results revealed that treatment with acrolein changed levels of several proteins in diverse physiological process including energy metabolism, cell communication and transport, response to stimulus and metabolic process. Interestingly, several differentially over-expressed proteins, including ?-synuclein, enolase and calcineurin, are known to be associated with human neurodegenerative diseases. Changes in the levels of some proteins were confirmed by Western blot. Moreover, acrolein increases the level of MDA, as a lipid peroxidation biomarker and decreased GSH concentrations, as a non-enzyme antioxidant in the brain of acrolein treated rats. These findings suggested that acrolein induces the oxidative stress and lipid peroxidation in the brain, and so that may contribute to the pathophysiology of neurological disorders. - Highlights: • Acrolein intoxication increased lipid peroxidation and deplete GSH in rat brain. • Effect of acrolein on protein levels of cerebral cortex was analyzed by 2DE-PAGE. • Levels of a number of proteins with different biological functions were increased.

Rashedinia, Marzieh; Lari, Parisa [Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of); Abnous, Khalil, E-mail: Abnouskh@mums.ac.r [Pharmaceutical Research Center, Department of Medicinal Chemistry, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of); Hosseinzadeh, Hossein, E-mail: Hosseinzadehh@mums.ac.ir [Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of)

2013-10-01T23:59:59.000Z

258

The oncogenic action of ionizing radiation on rat skin  

SciTech Connect (OSTI)

The multistage theory of carcinogenesis specifies that cells progress to cancer through a series of discrete, irreversible genetic alterations, but data on radiation-induced cancer incidence in rat skin suggests that an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to an electron beam (LET=0.34 keV/[mu]), a neon ion beam (LET=45) or an argon ion beam (LET=125). The rats were observed for tumors at least 78 weeks with squamous and basal cell carcinomas observed. The total cancer yield was fitted by the quadratic equation, and the equation parameters were estimated by linear regression for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces stable, carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable linked event pathway at high LET; either pathway may advance the cell by 1 stage. The proliferative response of rat epidermis following exposure to ionizing radiation was quantified by injection of [sup 14]C-thymidine. The return of these cells to S-phase a second time was detected by a second label ([sup 3]H). When the labeled cells were in G1-phase, the dorsal skin was irradiated with X-rays. All labeling indices were determined. The [sup 14]C labeling index was constant and unaffected by the radiation. The proportion of all cells entering S-phase averaged 3.5% at 18 hr and increased after 44, 52 and 75 hr to average levels of 11.8%, 5. 3%, and 6.6% at 0, 10 and 25 Gy respectively. The proportion of S-phase cells labeled with [sup 14]C increased after 42 hr and remained relatively constant thereafter.

Burns, F.J.; Garte, S.J.

1992-01-01T23:59:59.000Z

259

Organization and evolution of the rat tyrosine hydroxylase gene  

SciTech Connect (OSTI)

This report describes the organization of the rat tyrosine hydroxylase (TH) gene and compares its structure with the human phenylalanine hydroxylase gene. Both genes are single copy and contain 13 exons separated by 12 introns. Remarkably, the positions of 10 out 12 intron/exon boundaries are identical for the two genes. These results support the idea that these hydroxylases genes are members of a gene family which has a common evolutionary origin. The authors predict that this ancestral gene would have encoded exons similar to those of TH prior to evolutionary drift to other members of this gene family.

Brown, E.R.; Coker, G.T. III; O'Malley, K.L.

1987-08-11T23:59:59.000Z

260

Sodium alterations in isolated rat heart during cardioplegic arrest  

SciTech Connect (OSTI)

Triple-quantum-filtered (TQF) Na nuclear magnetic resonance (NMR) without chemical shift reagent is used to investigate Na derangement in isolated crystalloid perfused rat hearts during St. Thomas cardioplegic (CP) arrest. The extracellular Na contribution to the NMR TQF signal of a rat heart is found to be 73 {+-} 5%, as determined by wash-out experiments at different moments of ischemia and reperfusion. With the use of this contribution factor, the estimated intracellular Na ([Na{sup +}]{sub i}) TQF signal is 222 {+-} 13% of preischemic level after 40 min of CP arrest and 30 min of reperfusion, and the heart rate pressure product recovery is 71 {+-} 8%. These parameters are significantly better than for stop-flow ischemia: 340 {+-} 20% and 6 {+-} 3%, respectively. At 37{degrees}C, the initial delay of 15 min in [Na{sup +}]{sub i} growth occurs during CP arrest along with reduced growth later ({approximately}4.0%/min) in comparison with stop-flow ischemia ({approximately}6.7%/min). The hypothermia (21{degrees}C, 40 min) for the stop-flow ischemia and CP dramatically decreases the [Na{sup +}]{sub i} gain with the highest heart recovery for CP ({approximately}100%). These studies confirm the enhanced sensitivity of TQF NMR to [Na{sup +}]{sub i} and demonstrate the potential of NMR without chemical shift reagent to monitor [Na{sup +}]{sub i} derangements. 48 refs., 7 figs., 1 tab.

Schepkin, V.D.; Choy, I.O.; Budinger, T.F. [Lawrence Berkeley National Lab., CA (United States)

1996-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Effect of anesthesia on glucose production and utilization in rats  

SciTech Connect (OSTI)

This study was undertaken to determine the effects of pentobarbital anesthesia (50 mg/kg ip) on glucose kinetics and individual tissue glucose utilization in vivo, in chronically catheterized rats. Glucose turnover studies were carried out using (3-/sup 3/H) glucose as tracer. A transient hyperglycemia and an increased glucose production were observed 3 min after induction of anesthesia. However, 40 min after induction of anesthesia, glycemia returned to the level observed in awake animals, whereas glucose turnover was decreased by 30% as compared with unanesthetized rats. These results are discussed with regard to the variations observed in plasma insulin, glucagon, and catecholamine levels. Glucose utilization by individual tissues was studied by the 2-(1-/sup 3/H) deoxyglucose technique. A four- to fivefold decrease in glucose utilization was observed in postural muscles (soleus and adductor longus), while in other nonpostural muscles (epitrochlearis, tibialis anterior, extensor digitorum longus, and diaphragm) and other tissues (white and brown adipose tissues) anesthesia did not modify the rate of glucose utilization. A decrease in glucose utilization was also observed in the brain.

Penicaud, L.; Ferre, P.; Kande, J.; Leturque, A.; Issad, T.; Girard, J.

1987-03-01T23:59:59.000Z

262

Ozone induces glucose intolerance and systemic metabolic effects in young and aged brown Norway rats  

SciTech Connect (OSTI)

Air pollutants have been associated with increased diabetes in humans. We hypothesized that ozone would impair glucose homeostasis by altering insulin signaling and/or endoplasmic reticular (ER) stress in young and aged rats. One, 4, 12, and 24 month old Brown Norway (BN) rats were exposed to air or ozone, 0.25 or 1.0 ppm, 6 h/day for 2 days (acute) or 2 d/week for 13 weeks (subchronic). Additionally, 4 month old rats were exposed to air or 1.0 ppm ozone, 6 h/day for 1 or 2 days (time-course). Glucose tolerance tests (GTT) were performed immediately after exposure. Serum and tissue biomarkers were analyzed 18 h after final ozone for acute and subchronic studies, and immediately after each day of exposure in the time-course study. Age-related glucose intolerance and increases in metabolic biomarkers were apparent at baseline. Acute ozone caused hyperglycemia and glucose intolerance in rats of all ages. Ozone-induced glucose intolerance was reduced in rats exposed for 13 weeks. Acute, but not subchronic ozone increased ?{sub 2}-macroglobulin, adiponectin and osteopontin. Time-course analysis indicated glucose intolerance at days 1 and 2 (2 > 1), and a recovery 18 h post ozone. Leptin increased day 1 and epinephrine at all times after ozone. Ozone tended to decrease phosphorylated insulin receptor substrate-1 in liver and adipose tissues. ER stress appeared to be the consequence of ozone induced acute metabolic impairment since transcriptional markers of ER stress increased only after 2 days of ozone. In conclusion, acute ozone exposure induces marked systemic metabolic impairments in BN rats of all ages, likely through sympathetic stimulation. - Highlights: • Air pollutants have been associated with increased diabetes in humans. • Acute ozone exposure produces profound metabolic alterations in rats. • Age influences metabolic risk factors in aging BN rats. • Acute metabolic effects are reversible and repeated exposure reduces these effects. • Ozone metabolic effects are only slightly exacerbated in geriatric rats.

Bass, V. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Gordon, C.J.; Jarema, K.A.; MacPhail, R.C. [Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Cascio, W.E. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Phillips, P.M. [Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Ledbetter, A.D.; Schladweiler, M.C. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Andrews, D. [Research Cores Unit, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Miller, D. [Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC (United States); Doerfler, D.L. [Research Cores Unit, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Kodavanti, U.P., E-mail: kodavanti.urmila@epa.gov [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States)

2013-12-15T23:59:59.000Z

263

E-Print Network 3.0 - anesthetized lactating rats Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in situ and force in the rat plantaris muscle during repeated Effect of lactate infusion on M... .physiology.orgDownloadedfrom 12;Effect of lactate infusion on M-wave...

264

E-Print Network 3.0 - alpha-macroglobulin rat alpha Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

hormones such as ACTH, corticosterone, cytokines of IL-1beta, IL-6, and TNF-alpha in CIA rats were... .4. Diurnal variations of IL-1beta, TNF-alpha and IL-6 In our study, serum...

265

E-Print Network 3.0 - adult rat left Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult ... Source: Galef Jr.,...

266

E-Print Network 3.0 - adult wistar rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(C3H RIII)F1... 344Tox fdr FDRL fds Food and Drug Research Laboratories stock rats fis Fischer fmf Fischer 344Mai f... :(LE) lee Leeds albino lev Long-Evans lew Lewis lwj...

267

E-Print Network 3.0 - albinus rat wistar Sample Search Results  

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(C3H RIII)F1... 344Tox fdr FDRL fds Food and Drug Research Laboratories stock rats fis Fischer fmf Fischer 344Mai f... :(LE) lee Leeds albino lev Long-Evans lew Lewis lwj...

268

E-Print Network 3.0 - adult rat heart Sample Search Results  

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heart Search Powered by Explorit Topic List Advanced Search Sample search results for: adult rat heart Page: << < 1 2 3 4 5 > >> 1 doi:10.1152ajpheart.00114.2006 291:496-506,...

269

E-Print Network 3.0 - acetate-salt hypertensive rats Sample Search...  

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hypertensive rats Page: << < 1 2 3 4 5 > >> 1 ISSN: 1524-4563 Copyright 2005 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online Summary: hypertensive...

270

E-Print Network 3.0 - adult rats spinalized Sample Search Results  

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Search Sample search results for: adult rats spinalized Page: << < 1 2 3 4 5 > >> 1 Brain Research 918 (2001) 101106 www.elsevier.comlocatebres Summary: play a minor role in...

271

E-Print Network 3.0 - adult rat spinal Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Advanced Search Sample search results for: adult rat spinal Page: << < 1 2 3 4 5 > >> 1 Brain Research 918 (2001) 101106 www.elsevier.comlocatebres Summary: play a minor role in...

272

The effect of Zoledronate treatment timing on lumbar and caudal vertebrae in ovariectomized rats  

E-Print Network [OSTI]

Introduction: While there have been numerous studies demonstrating the effect of bisphosphonates in rats as either a preventative treatment or recovering treatment for osteoporosis, few have directly compared the two ...

Ruchelsman, Michal (Michal Aliza)

2007-01-01T23:59:59.000Z

273

The Lower Keys marsh rabbit and silver rice rat: steps toward recovery  

E-Print Network [OSTI]

be detrimentally impacted by hardwood encroachment into salt-marsh habitats. For LKMR recovery, I recommend management to resist hardwood encroachment, together with active predator control. I surveyed 36 locations on 18 islands for SRRs, capturing rats on 12...

Perry, Neil Desmond

2006-10-30T23:59:59.000Z

274

E-Print Network 3.0 - adult rat sacral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

capensis) from Cape Town. Used with the permission of the pho... . Georychus capensis (Pallas, 1778) Cape Mole-rat Mus capensis Pallas, 1778:172. Type locality ... Source: Hayssen,...

275

Effects of insulin on messenger RNA activities in rat liver  

SciTech Connect (OSTI)

Liver poly(A) RNA, isolated from adrenalectomized rats after insulin treatment, was translated in a nuclease-treated lysate of rabbit reticulocytes and quantitated for both total activity and the capacity to synthesize the insulin-inducible enzyme tyrosine amino-transferase. Analysis of the translated products from poly(A) RNA isolated 1 h after insulin treatment showed a 2.7-fold increase in activity of tyrosine aminotransferase mRNA. During the same interval, the capacity of poly(A) RNA to direct the synthesis of total protein in lysates also changed, showing a 30 to 40% increase in translational activity/unit of RNA. Increased translatability was apparent in all fractions of poly(A) RNA separated by centrifugation on sucrose gradients. Insulin thus appears to mediated a generalized changed in mRNAs leading to increased capacity for translation; induction of tyrosine aminotransferase may reflect unusual sensitivity to this effect of the hormone.

Hill, R.E. (Univ. of Tennessee, Oak Ridge); Lee, K.L.; Kenney, F.T.

1981-02-25T23:59:59.000Z

276

The effects of radiation on spermatogenesis in the albino rat as determined by semen analysis  

E-Print Network [OSTI]

rate all could be significant factors. Total body X-irradiation (470 r) in rats produced minimal alterations in the testes, namely depletion of spermatogonia (Gunn, et al. , 1960). 17 18 The effect of whole-body radiation on fertility of male rats...) Figure 22. Effect of Radiation on Weight Change (Chronic). no irradiation, demonstrated steady weekly increases through the investigation period. The average body weight of these animals at the initiation of this study was approximately 510 grams...

Lawson, Rommon Loy

1964-01-01T23:59:59.000Z

277

Sodium and potassium levels in the serum of acutely irradiated and non-irradiated rats  

E-Print Network [OSTI]

SODIUM AND POTASSIUM LEVELS IN THE SERUM OF ACUTELY IRRADIATED AND NON-IRRADIATED RATS A Thesis By DAVID PRESTON SHEPHERD Submitted to the Graduate College of the Texas ARM University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE August 1967 Major Subject: Zoology SODIUM AND POTASSIUM LEVELS IN THE SERUM OF ACUTELY IRRADIATED AND NON-IRRADIATED RATS A Thesis By DAVID PRESTON SHEPHERD Approved as to style and content by: (Chairman of Committee) (Head...

Shepherd, David Preston

1967-01-01T23:59:59.000Z

278

Copper induced osteopenia and its relationship to the development of postmenopausal osteoporosis in the rat  

E-Print Network [OSTI]

COPPER INDUCED OSTEOPENIA AND ITS RELATIONSHIP TO THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSIS IN THE RAT A Thesis CINDY DEANN YEE Submitted to the Office of Graduate Studies of Texas ASM University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1992 Major Subject: Nutrition COPPER INDUCED OSTEOPENIA AND ITS RELATIONSHIP TO THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSIS IN THE RAT A Thesis CINDY DEANN YEE Approved as to style and content...

Yee, Cindy Deann

1992-01-01T23:59:59.000Z

279

Tissue magnesium and calcium concentration in relation to magnesium and calcium intake in rats  

E-Print Network [OSTI]

TISSUE MAGNESIUM AND CALCIUM CONCENTRATION IN RELATION TO MAGNESIUM AND CALCIUM INTAKE IN RATS A Thesis by CARRIE STANTON PINKRAM Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirerrents... for the degree of MASTER OF SCIENCE August 1987 Major Subject: Nutrition TISSUE MAGNESIUM AND CALCIUM CONCENTRATION IN RELATION TO MAGNESIUM AND CALCIUM INTAKE IN RATS A Thesis by CARRIE STANTON PINKHAM Approved as to style and content by: Karen S...

Pinkham, Carrie Stanton

2012-06-07T23:59:59.000Z

280

Magnesium and pyridoxine intake and mineral content of selected tissues and physical development in rats  

E-Print Network [OSTI]

MAGNESIUM AND PYRIDOXINE INTAKE MINERAL CONTENT OF SELECTED TISSUES PHYSICAL DEVELOPMENT IN RATS A Thesis by SU S AN ELA I NE EDGAR Submitted to the Graduate College of Texas A8rM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 1986 Major Subject: Nutrition MAGNESIUM AND PYRIDOXINE INTAKE MINERAL CONTENT OF SELECTED TISSUES PHYS ICAL DEVELOPMENT IN RATS A Thesis by SUSAN ELAINE EDGAR Approved as to style and content by: 'KAREN...

Edgar, Susan Elaine

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

LES TYROSINASES CUTANES CHEZ LE RAT. MODIFICATIONS AU COURS DU DVELOPPEMENT  

E-Print Network [OSTI]

LES TYROSINASES CUTAN�ES CHEZ LE RAT. MODIFICATIONS AU COURS DU D�VELOPPEMENT ET PENDANT LE CYCLE Sciences appliquées, 69621 Villeurbanne 1 1 R�SUM� Nous avons effectué l'étude des tyrosinases de la peau chez le Rat. Ces tyrosinases sont mises en évidence, après électrophorèse par réaction de Dopa sur gel

Boyer, Edmond

282

Prolactin and aging: X-irradiated and estrogen-induced rat mammary tumorigenesis  

SciTech Connect (OSTI)

Both sexes of inbred WF rats at either 8 or 28-60 weeks of age were exposed to 200 rad whole-body radiation, 2.5 or 5.0 mg 17 beta-estradiol (E2), or both agents The female rats treated with E2 alone or with both X-rays and E2 at 8 weeks of age showed a high incidence of mammary carcinomas (MCA), a large increase in pituitary weight, and a rise in serum prolactin (PRL) levels. However, the same treatments to males did not induce MCA despite a moderate increase in both pituitary weight and serum PRL. Ovariectomy prior to E2 treatment failed to modify the occurrence of MCA or pituitary tumors. When X-rays and E2 were given to female rats at 28-60 weeks of age, pituitary weight, serum PRL levels, and the incidence of MCA were unaffected. When the E2 pellet was kept for the first 24 weeks and withdrawn during the last 12 weeks, the incidence of MCA, pituitary weight, and serum PRL was low. It was concluded that: 1) the pituitary glands of young female rats were susceptible to E2 treatment but were insensitive in older females, and 2) the occurrence of MCA in female rats appeared to be promoted by elevated PRL levels secreted by E2-induced pituitary tumors. Mammary tissue of male rats was less sensitive to PRL levels in the development of MCA.

Ito, A.; Naito, M.; Watanabe, H.; Yokoro, K.

1984-07-01T23:59:59.000Z

283

Ovariectomized Sprague-Dawley and Long-Evans rats release prolactin differently in response to estrogen  

SciTech Connect (OSTI)

Mature female Sprague-Dawley (SD) and Long-Evans (LE) rats were ovariectomized (OVX), and given a single sc injection of either 25 or 100 ..mu..g polyestradiol phosphate (PEP); seven days later blood samples were withdrawn at two hour intervals from 1100 to 2100 hours to detect the presence of an afternoon surge of prolactin (PRL). Other groups of OVX rats of both strains also treated with PEP were sampled before and at 2, 5, 10 and 30 min after iv administration of 1 ..mu..g synthetic thyrotropin releasing hormone (TRH). Pituitary (AP) and uterine weights were determined following sacrifice one day after TRH treatment. The AP homogenates and plasma samples were assayed for PRL by radioimmunoassay. Rats of both strains had afternoon PRL surges and in both strains the magnitude and/or duration of the surges were enhanced by the higher dose of PEP. However, within each PEP dose LE rats released significantly more PRL during the surge than did SD drats. Rats of both strains also rleased PRL in response to TRH and this response was enhanced in both strains by the higher of the two doses of PEP. These data not only show that strain differences exist in estrogen-induced or mediated PRL release in the rat but also indicate that the differences are not uniform.

Lawson, D.M.; Sensui, N.; Gala, R.R.

1984-01-30T23:59:59.000Z

284

Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models  

SciTech Connect (OSTI)

Methyl palmitate (MP) and ethyl palmitate (EP) are naturally occurring fatty acid esters reported as inflammatory cell inhibitors. In the current study, the potential anti-inflammatory activity of MP and EP was evaluated in different experimental rat models. Results showed that MP and EP caused reduction of carrageenan-induced rat paw edema in addition to diminishing prostaglandin E2 (PGE2) level in the inflammatory exudates. In lipopolysaccharide (LPS)-induced endotoxemia in rats, MP and EP reduced plasma levels of tumor necrosis factor-? (TNF-?) and interleukin-6 (IL-6). MP and EP decreased NF-?B expression in liver and lung tissues and ameliorated histopathological changes caused by LPS. Topical application of MP and EP reduced ear edema induced by croton oil in rats. In the same animal model, MP and EP reduced neutrophil infiltration, as indicated by decreased myeloperoxidase (MPO) activity. In conclusion, this study demonstrates the effectiveness of MP and EP in combating inflammation in several experimental models. -- Highlights: ? Efficacy of MP and EP in combating inflammation was displayed in several models. ? MP and EP reduced carrageenan-induced rat paw edema and prostaglandin E2 level. ? MP and EP decreased TNF-? and IL-6 levels in experimental endotoxemia. ? MP and EP reduced NF-?B expression and histological changes in rat liver and lung. ? MP and EP reduced croton oil-induced ear edema and neutrophil infiltration.

Saeed, Noha M. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt); El-Demerdash, Ebtehal [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt); Abdel-Rahman, Hanaa M. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt); Algandaby, Mardi M. [Department of Biology (Botany), Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)] [Department of Biology (Botany), Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia); Al-Abbasi, Fahad A. [Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)] [Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia); Abdel-Naim, Ashraf B., E-mail: abnaim@pharma.asu.edu.eg [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)

2012-10-01T23:59:59.000Z

285

Dose-Response Effect of Charged Carbon Beam on Normal Rat Retina Assessed by Electroretinography  

SciTech Connect (OSTI)

Purpose: To compare the effects of carbon beam irradiation with those of proton beam irradiation on the physiology of the retina of rats. Methods and Materials: Eight-week-old Wister rats were used. The right eyes were irradiated with carbon beam (1, 2, 4, 8, and 16 Gy) or proton beam (4, 8, 16, and 24 Gy) with the rats under general anesthesia. Electroretinograms were recorded 1, 3, 6, and 12 months after the irradiation, and the amplitudes of the a and b waves were compared with those of control rats. Results: The amplitude of b waves was reduced more than that of a waves at lower irradiation doses with both types of irradiation. With carbon ion irradiation, the amplitudes of the b wave were significantly reduced after radiation doses of 8 and 16 Gy at 6 months and by radiation doses of 4, 8, and 16 Gy at 12 months. With proton beam irradiation, the b-wave amplitudes were significantly reduced after 16 and 24 Gy at 6 months and with doses of 8 Gy or greater at 12 months. For the maximum b-wave amplitude, a significant difference was observed in rats irradiated with carbon beams of 4 Gy or more and with proton beams of 8 Gy or more at 12 months after irradiation. Conclusions: These results indicate that carbon beam irradiation is about two times more damaging than proton beam irradiation on the rat retina at the same dose.

Mizota, Atsushi, E-mail: mizota-a@med.teikyo-u.ac.j [Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan); Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu (Japan); Tanaka, Minoru [Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu (Japan); Kubota, Mariko; Negishi, Hisanari [Department of Ophthalmology, National Hospital Organization Chiba Medical Center, Chiba (Japan); Watanabe, Emiko [Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan); Tsuji, Hiroshi; Miyahara, Nobuyuki; Furusawa, Yoshiya [National Institute of Radiological Sciences, Chiba (Japan)

2010-12-01T23:59:59.000Z

286

The effects of exercise and dietary fat on calcium, magnesium, iron, and zinc on selected tissues in rats  

E-Print Network [OSTI]

and had a 12-hour photoperiod. Cages were lined with woodchip bedding, and stainless steel feeders were used. Design Following a three-day acclimation period, during which rats were fed the control diet, the rats were weighed and randomly assigned... the reliability of exhaustive swimming in the laboratory rat. Male albino rats exhibited exercise oxygen consumption of 2. 7 times the resting level in a no-weight applied condition after swimming for 5 to 30 minutes. At a load of 2% body weight, oxygen...

Nguyen, Thuy Huong

1989-01-01T23:59:59.000Z

287

Differences in pulmonary responses of rats, other animals, and humans to chronic inhalation of silica and other particles  

SciTech Connect (OSTI)

The pulmonary carcinogenicity of quartz in rats supports the plausibility of silica-induced lung cancer in humans. However, pulmonary responses of rats to dusts differ from those of other rodents, and may differ from those of humans. Dust-exposed rats have a greater propensity than mice or hamsters for epithelial hyperplasia, metaplasia, and fibrosis. Lung tumors occur in rats, but not mice or hamsters, treated with quartz, or exposed chronically to several other dusts. There are few opportunities for directly comparing the susceptibilities of rats and humans to dust-induced lung tumors. Because of the uncertain human responses to silica and many other particles, the negative human lung cancer response to coal dust may provide the best opportunity to calibrate responses of rats against those of humans. Historical dust lung burdens in coal miners were in the range of those associated with carcinogenicity in rats exposed to several dusts, but the carcinogenicity of coal dust in rats is unknown. The usefulness of tumor data from rats for predicting human lung cancer risk from inhaled silica and other dusts remains uncertain.

Mauderly, J.L.

1993-12-31T23:59:59.000Z

288

Comparative Metabolism of Carbon Tetrachloride in Rats, Mice and Hamsters Using Gas Uptake and PBPK Modeling  

SciTech Connect (OSTI)

No study has comprehensively compared the rate of metabolism of carbon tetrachloride (CCl4) across species. Therefore, the in vivo metabolism of CCl4 was evaluated using groups of male animals (F344 rats, B6C3F1 mice, and Syrian hamsters) exposed to 40-1800 ppm CCl4 in a closed, recirculating gas-uptake system. For each species, an optimal fit of the family of uptake curves was obtained by adjusting Michaelis-Menten metabolic constants Km (affinity) and Vmax (capacity) using a physiologically based pharmacokinetic (PBPK) model. The results show that the mouse has a slightly higher capacity and lower affinity for metabolizing CCl4 compared to the rat, while the hamster has a higher capacity and lower affinity than either rat or mouse. A comparison of the Vmax to Km ratio, normalized for mg of liver protein (L/hr/mg) across species indicates that hamsters metabolize more CCl4 than either rats or mice, and should be more susceptible to CCl4-induced hepatotoxicity. These species comparisons were evaluated against toxicokinetic studies conducted in animals exposed by nose-only inhalation to 20 ppm 14C-labeled CCl4 for 4 hours. The toxicokinetic study results are consistent with the in vivo rates of metabolism, with rats eliminating less radioactivity associated with metabolism (14CO2 and urine/feces) and more radioactivity associated with the parent compound (radioactivity trapped on charcoal) compared to either hamsters or mice. The in vivo metabolic constants determined here, together with in vitro constants determined using rat, mouse, hamster and human liver microsomes, were used to estimate human in vivo metabolic rates of 1.49 mg/hr/kg body weight and 0.25 mg/L for Vmax and Km, respectively. Normalizing the rate of metabolism (Vmax/Km) by mg liver protein, the rate of metabolism of CCl4 differs across species, with hamster > mouse& > rat > human.

Thrall, Karla D. (BATTELLE (PACIFIC NW LAB)); Vucelick, Mark E. (FLUOR HANFORD, INC); Gies, Richard A. (BATTELLE (PACIFIC NW LAB)); Zangar, Richard C. (BATTELLE (PACIFIC NW LAB)); Weitz, Karl K. (BATTELLE (PACIFIC NW LAB)); Poet, Torka S. (BATTELLE (PACIFIC NW LAB)); Springer, David L. (BATTELLE (PACIFIC NW LAB)); Grant, Donna M. (BATTELLE (PACIFIC NW LAB)); Benson, Janet M. (Inhalation Toxicology Research Institute)

2000-08-25T23:59:59.000Z

289

Inhalation carcinogenicity study with nickel metal powder in Wistar rats  

SciTech Connect (OSTI)

Epidemiological studies of nickel refinery workers have demonstrated an association between increased respiratory cancer risk and exposure to certain nickel compounds (later confirmed in animal studies). However, the lack of an association found in epidemiological analyses for nickel metal remained unconfirmed for lack of robust animal inhalation studies. In the present study, Wistar rats were exposed by whole-body inhalation to 0, 0.1, 0.4, and 1.0 mg Ni/m{sup 3} nickel metal powder (MMAD = 1.8 {mu}m, GSD = 2.4 {mu}m) for 6 h/day, 5 days/week for up to 24 months. A subsequent six-month period without exposures preceded the final euthanasia. High mortality among rats exposed to 1.0 mg Ni/m{sup 3} nickel metal resulted in the earlier termination of exposures in this group. The exposure level of 0.4 mg Ni/m{sup 3} was established as the MTD for the study. Lung alterations associated with nickel metal exposure included alveolar proteinosis, alveolar histiocytosis, chronic inflammation, and bronchiolar-alveolar hyperplasia. No increased incidence of neoplasm of the respiratory tract was observed. Adrenal gland pheochromocytomas (benign and malignant) in males and combined cortical adenomas/carcinomas in females were induced in a dose-dependent manner by the nickel metal exposure. The incidence of pheochromocytomas was statistically increased in the 0.4 mg Ni/m{sup 3} male group. Pheochromocytomas appear to be secondary to the lung toxicity associated with the exposure rather than being related to a direct nickel effect on the adrenal glands. The incidence of cortical tumors among 0.4 mg Ni/m{sup 3} females, although statistically higher compared to the concurrent controls, falls within the historical control range; therefore, in the present study, this tumor is of uncertain relationship to nickel metal exposure. The lack of respiratory tumors in the present animal study is consistent with the findings of the epidemiological studies.

Oller, Adriana R. [NiPERA, 2605 Meridian Parkway, Suite 200, Durham, NC 27713 (United States)], E-mail: aoller@nipera.org; Kirkpatrick, Daniel T.; Radovsky, Ann [WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805 8946 (United States); Bates, Hudson K. [NiPERA, 2605 Meridian Parkway, Suite 200, Durham, NC 27713 (United States)

2008-12-01T23:59:59.000Z

290

In vitro dermal absorption of pyrethroid pesticides in human and rat skin  

SciTech Connect (OSTI)

Dermal exposure to pyrethroid pesticides can occur during manufacture and application. This study examined the in vitro dermal absorption of pyrethroids using rat and human skin. Dermatomed skin from adult male Long Evans rats or human cadavers was mounted in flow-through diffusion cells, and radiolabeled bifenthrin, deltamethrin or cis-permethrin was applied in acetone to the skin. Fractions of receptor fluid were collected every 4 h. At 24 h, the skins were washed with soap and water to remove unabsorbed chemical. The skin was then solubilized. Two additional experiments were performed after washing the skin; the first was tape-stripping the skin and the second was the collection of receptor fluid for an additional 24 h. Receptor fluid, skin washes, tape strips and skin were analyzed for radioactivity. For rat skin, the wash removed 53-71% of the dose and 26-43% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid ranged from 1 to 5%. For human skin, the wash removed 71-83% of the dose and 14-25% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid was 1-2%. Tape-stripping removed 50-56% and 79-95% of the dose in rat and human skin, respectively, after the wash. From 24-48 h, 1-3% and about 1% of the dose diffused into the receptor fluid of rat and human skin, respectively. The pyrethroids bifenthrin, deltamethrin and cis-permethrin penetrated rat and human skin following dermal application in vitro. However, a skin wash removed 50% or more of the dose from rat and human skin. Rat skin was more permeable to the pyrethroids than human skin. Of the dose in skin, 50% or more was removed by tape-stripping, suggesting that permeation of pyrethroids into viable tissue could be impeded. The percentage of the dose absorbed into the receptor fluid was considerably less than the dose in rat and human skin. Therefore, consideration of the skin type used and fractions analyzed are important when using in vitro dermal absorption data for risk assessment.

Hughes, Michael F., E-mail: hughes.michaelf@epa.go [Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Edwards, Brenda C. [Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States)

2010-07-15T23:59:59.000Z

291

Correction par voie nutritionnelle d'un excs d'acides gras insaturs dans les lipides corporels du rat en croissance  

E-Print Network [OSTI]

). Hydrogenated coconut oil was a very effective substance for rapidly decreasing levels of reserve lipid linoleic acids in body lipids of growing rat. The use of hydrogenated coconut oil as a putative substance for correcting an excess of unsaturated fatty acids in reserve lipids was tested in growing rats. Young rats

Boyer, Edmond

292

Dietary apigenin and naringenin protect against colon carcinogenesis by lowering high multiplicity aberrant crypt foci and enhancing apoptosis in azoxymethane-treated rats  

E-Print Network [OSTI]

investigated the potentially protective effects of four citrus flavonoids and one limonoid mixture against the promotion stage of chemically-induced colon cancer in rats. Male SD rats (n =60; 10 rats/group) were assigned to receive diets containing 0...

Leonardi, Tety

2006-08-16T23:59:59.000Z

293

Physiologically based Pharmacokinetic Modeling of 1,4-Dioxane in Rats, Mice, and Humans  

SciTech Connect (OSTI)

ABSTRACT 1,4-Dioxane (CAS No. 123-91-1) is used primarily as a solvent or as a solvent stabilizer. It can cause lung, liver and kidney damage at sufficiently high exposure levels. Two physiologically-based pharmacokinetic (PBPK) models of 1,4-dioxane and its major metabolite, hydroxyethoxyacetic acid (HEAA), were published in 1990. These models have uncertainties and deficiencies that could be addressed and the model strengthened for use in a contemporary cancer risk assessment for 1,4-dioxane. Studies were performed to fill data gaps and reduce uncertainties pertaining to the pharmacokinetics of 1,4-dioxane and HEAA in rats, mice, and humans. Three types of studies were performed:partition coefficient measurements, blood time course in mice, and in vitro pharmacokinetics using rat, mouse, and human hepatocytes. Updated PBPK models were developed based on these new data and previously available data. The optimized rate of metabolism for the mouse was significantly higher than the value previously estimated. The optimized rat kinetic parameters were similar to those in the 1990 models. Only two human studies were identified. Model predictions were consistent with one study, but did not fit the second as well. In addition, a rat nasal exposure was completed. The results confirmed water directly contacts rat nasal tissues during drinking water under bioassays. Consistent with previous PBPK models, nasal tissues were not specifically included in the model. Use of these models will reduce the uncertainty in future 1,4-dioxane risk assessments.

Sweeney, Lisa M.; Thrall, Karla D.; Poet, Torka S.; Corley, Rick; Weber, Thomas J.; Locey, B. J.; Clarkson, Jacquelyn; Sager, S.; Gargas, M. L.

2008-01-01T23:59:59.000Z

294

Extracellular calcium sensing in rat aortic vascular smooth muscle cells  

SciTech Connect (OSTI)

Extracellular calcium (Ca2+o) can act as a first messenger in many cell types through a G protein-coupled receptor, calcium-sensing receptor (CaR). It is still debated whether the CaR is expressed in vascular smooth muscle cells (VSMCs). Here, we report the expression of CaR mRNA and protein in rat aortic VSMCs and show that Ca2+o stimulates proliferation of the cells. The effects of Ca2+o were attenuated by pre-treatment with MAPK kinase 1 (MEK1) inhibitor, as well as an allosteric modulator, NPS 2390. Furthermore, stimulation of the VSMCs with Ca2+o-induced phosphorylation of ERK1/2, but surprisingly did not cause inositol phosphate accumulation. We were not able to conclusively state that the CaR mediates Ca2+o-induced cell proliferation. Rather, an additional calcium-sensing mechanism may exist. Our findings may be of importance with regard to atherosclerosis, an inflammatory disease characterized by abnormal proliferation of VSMCs and high local levels of calcium.

Smajilovic, Sanela [Laboratory of Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet (Denmark); Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen (Denmark); Hansen, Jakob Lerche [Laboratory of Molecular and Cellular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet (Denmark); Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen (Denmark); Christoffersen, Tue E.H. [Laboratory of Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet (Denmark); Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen (Denmark)] (and others)

2006-10-06T23:59:59.000Z

295

Deregulation of Hepatic Insulin Sensitivity Induced by Central Lipid Infusion in Rats Is Mediated by Nitric Oxide  

E-Print Network [OSTI]

Deregulation of Hepatic Insulin Sensitivity Induced by Central Lipid Infusion in Rats Is Mediated effect of central lipid overload. Thus we infused rats for 24 hours into carotid artery towards brain). Principal Findings: Lipids infusion led to hepatic insulin-resistance partly related to a decreased

Routh, Vanessa H.

296

Methods for testing the strength of cancellous bone and tested method effects on cortical bone in the ovariectomized rat  

E-Print Network [OSTI]

In this study, two mechanical testing procedures were developed to test the strength of cancellous bone from the proximal tibia of the rat, the "punch method" and the "whole slice method". These were used to quantify the effect of ovariectomy on rat...

Ruhmann, Sean Phillip

1998-01-01T23:59:59.000Z

297

Cardiovascular changes in unanesthetized and ketamine-anesthetized Sprague-Dawley rats exposed to 2. 8-GHz radiofrequency radiation  

SciTech Connect (OSTI)

Sprague-Dawley rats were exposed to 2.8-GHz radiofrequency radiation, first while unanesthetized and then while anesthetized with ketamine (150 mg/kg.I.M.). Irradiation at a power density of 60 mW/cm2 (whole-body average specific absorption rate of approximately 14 W/kg) was conducted for sufficient duration to increase colonic temperature from 38.5 to 39.5 degrees C. The time required for the temperature increase was significantly longer in the anesthetized state. During irradiation, heart rate increased significantly both with and without anesthesia, while mean arterial blood pressure increased only when the rats were unanesthetized. The heart rate increase in the anesthetized state contrasts with a lack of change in a previous study of Fischer rats. This difference between anesthetized Sprague-Dawley and Fischer rats should be considered when comparing cardiovascular data obtained from these two strains of rats.

Jauchem, J.R.; Frei, M.R. (United States Air Force School of Aerospace Medicine, Brooks Air Force Base, TX (USA))

1991-01-01T23:59:59.000Z

298

Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease  

SciTech Connect (OSTI)

Rat fibroblasts were infected with a retroviral vector containing the cDNA for rat tyrosine hydroxylase. A TH-positive clone was identified by biochemical assay and immunohistochemical staining. When supplemented in vitro with pterin cofactors required for TH activity, these cells produced L-dopa and released it into the cell cultured medium. Uninfected control cells and fibroblasts infected with the TH vector were grafted separately to the caudate of rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. Only grafts containing TH-expressing fibroblasts were found to reduce rotational asymmetry. These results have general implications for the application of gene therapy to human neurological disease and specific implications for Parkinson disease.

Wolff, J.A.; Fisher, L.J.; Xu, L.; Jinnah, H.A.; Rosenberg, M.B.; Shimohama, S.; Gage, F.H. (Univ. of California School of Medicine, La Jolla (USA)); Langlais, P.J. (Univ. of California School of Medicine, La Jolla (USA) School of Medicine and Veterans Administration Medical Center, La Jolla (USA) San Diego State Univ., CA (USA)); Iuvone, P.M. (Emory Univ., Atlanta, GA (USA)); O'Malley, K.L. (Washington Univ. School of Medicine, St. Louis, MO (USA))

1989-11-01T23:59:59.000Z

299

Chronic cellular responses of rat skin to 13 Mev proton irradiation  

E-Print Network [OSTI]

CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas AErM University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1966 Major Subject: Laboratory Animal Medicine CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas ARM University in partial...

Hinkle, Donald King

1966-01-01T23:59:59.000Z

300

The inability of rats to synthesize linoleic acid from cis-2-octenoic acid  

E-Print Network [OSTI]

THE INABILITY OF RATS TO SYNTHESI2E LINOLEIC ACID FROM CIS-2-OCTENOIC ACID A Thesis Robert Eugene Anderson Submitted to the Graduate College of the Texas A g: M University in partia1 fulfillment of the requirerents for the degree of MASTER... OF SCIENCE January 1965 Major Subjeot: Bioohemistry THE INABILITY OF RATS TQ SYNTHESIEE LINOLEIC ACID FROM CIS-2E)CTENOIC ACID A Thesis Robert, Eugene Anderson Approved as to style and content by: Chair n of Committee)~ (Head of Depart~ant, Member...

Anderson, Robert Eugene

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Effect of passive and active immunization against somatostatin in growing rats and cattle  

E-Print Network [OSTI]

as in Exp. 1. Rats were infused daily with . 50 ml of either anti-SS or NGS and weighed every fifth day. Antiserum used to infuse treatment rats was the same used in Exp. l. 81ood samples were taken via cannula on d 5, 10, 15 and 20 of the experiment... calculated on 10 determinations of four plasma samples containing 1, 6, 10 and 30 ng GH/ml was 2, 3. 5, 6. 5, and 22. 8% respectively. The interassay coefficient of variation calculated on determination of the same four plasma samples in four different...

Lawrence, Mark Elliott

1985-01-01T23:59:59.000Z

302

Toxicity of polychlorinated diphenyl ethers in Hydra attenuata and in rat whole embryo culture  

E-Print Network [OSTI]

TOXICITY OF POLYCHLORINATED DIPHENYL ETHERS IN HYDRA A?TENUATA AND IN RAT WHOLE EMBRYO CULTURE A Thesis by MARION CAROL BECKER Submitted to the Office of Graduate Studies of Texas A8cM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 1991 Major Subject: Toxicology TOXICITY OF POLYCHLORINATED DIPHENYL ETHERS IN HYDRA A1TENUATA AND IN RAT WHOLE EMBRYO CULTURE by MARION CAROL BECKER Approved as to style and content by: Stephen H. S (Ca...

Becker, Marion Carol

1991-01-01T23:59:59.000Z

303

Systematics of the southern races of two species of kangaroo rats (Dipodomys compactus and D. ordi)  

E-Print Network [OSTI]

University Chairman of Advisory Committee: Dr. David J. Schmidly The systematics of two species of kangaroo rats (g D~*d ~ ) f o y d * t!l* M * reviewed. Nongeographic and geographic variation was assessed among 63 samples (representing approximately... and that more than one biological species may occur 'n the area. These above studies imply tnat the ktngaroo rats from the barrier islands of Texas and H ' o ( f d t ~D' d 9 P T ', 1999( are specifically distinct from populations on the tt T ' 1 d ( f d t...

Baumgardner, George D

1979-01-01T23:59:59.000Z

304

Associative tolerance to nicotine analgesia in the rat: tail-flick and hot-plate assays  

E-Print Network [OSTI]

studies (e. g. , Miller, Rotenberg, 8c Adir, 1977; Sastry et al. , 1995) of intravenous (i. v. ) nicotine injections (0. 08, 0. 40, 0. 8 mg/kg and 1mg/kg respectively) in the rat (Sprague-Dawley and Fischer F344) indicate that it is rapidly... and extensively distributed and absorbed into the blood, brain, liver, and kidneys, and that it rapidly reaches peak concentrations. Sastry et al. (1995) reported peak nicotine levels in the rat brain, kidneys and liver were reached within five to ten minutes...

Reynoso, Jose T.

2012-06-07T23:59:59.000Z

305

3-Methylhistidine excretion as an index of dietary protein adequacy in the rat  

E-Print Network [OSTI]

. Landmann The excretion of the amino acid, 3-methylhistidine (Nz-methyl- histidine, 3-MeHis), in urine has been shown to correlate with skel- etal muscle breakdown. In the rat, tissues such as skin, viscera, and liver in addition to skeletal muscle...-MeHis indicates the degree of catabolism of body proteins in rats (3). In addition to the contzibution of skeletal muscle, the higher turnover rate of skin, visceza, and liver contributes significantly to whole body protein breakdown in small...

Kirby, Rebecca Kay

2012-06-07T23:59:59.000Z

306

Yu kan vertrouw mi: você pode confiar.  

E-Print Network [OSTI]

??Ao longo das duas últimas décadas, têm se tornado comum encontrar imigrantes brasileiros em Paramaribo, capital do Suriname. A paisagem urbana vem sendo modificada pela… (more)

Carolina Carret Höfs

2006-01-01T23:59:59.000Z

307

Yu kan vertrouw mi : você pode confiar.  

E-Print Network [OSTI]

??Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Sociais, Departamento de Antropologia, Programa de Pós-graduação em Antropologia Social, 2006. Ao longo das duas últimas décadas, têm… (more)

Höfs, Carolina Carret

2006-01-01T23:59:59.000Z

308

Marysville, MI Natural Gas Exports to Canada  

Gasoline and Diesel Fuel Update (EIA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines About U.S.30Natural Gas Glossary529 6330 0 14343Decade81 170 115 89 1164,925 22,198

309

Detroit, MI Natural Gas Exports to Canada  

Gasoline and Diesel Fuel Update (EIA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines About U.S.30Natural Gas Glossary529 633 622 56623 4623 42YearDelawareDetails of U.S.80

310

Microsoft Word - MI.01-8.doc  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou$ EGcGand Surface WaterthroughLEGAL NOTICE

311

Theorem: L : Z List. ( p :{Z Z | let m, i = p in max_seg_sum(m; L) max_initseg_sum(i; L)}) L:Z List. (p:{Z Z| let m,i = p in max_seg_sum(m;L) max_initseg_sum(i;L)})  

E-Print Network [OSTI]

(u;u + p2) initseg_sum(r;[u; u1 / v]) )) 2 #12;Theorem: L : Z List. ( p :{Z Ã? Z | let m, i = p in maxTheorem: L : Z List. ( p :{Z Ã? Z | let m, i = p in max_seg_sum(m; L) max_initseg_sum(i; L)}) L:Z List. (p:{Z Ã? Z| let m,i = p in max_seg_sum(m;L) max_initseg_sum(i;L)}) | BY (D 0 THENA Auto) | 1. L

312

Uptake and retention kinetics of para-fluorine-18-fluorobenzylguanidine in isolated rat heart  

SciTech Connect (OSTI)

Para-[{sup 18}F]fluorobenzylguanidine ([{sup 18}F]PFBG) is a newly developed tracer for imaging myocardial sympathetic neuronal innervation. This study investigated the uptake and retention mechanisms of [{sup 18}F]PFBG in perfused, isolated rat heart. 31 refs., 3 figs., 2 tabs.

Berry, C.R.; Garg, P.K.; Zalutsky, M.R. [North Carolina State Univ., Raleigh, NC (United States)]|[Duke Univ. Medical Center, Durham, NC (United States)] [and others

1996-12-01T23:59:59.000Z

313

Beneficial Effects of Hematopoietic Growth Factor Therapy in Chronic Ischemic Stroke in Rats  

E-Print Network [OSTI]

Beneficial Effects of Hematopoietic Growth Factor Therapy in Chronic Ischemic Stroke in Rats Li. Vania Apkarian, PhD; John A. Kessler, MD Background and Purpose--Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF

Apkarian, A. Vania

314

The Effects of Alcohol and Age on Astrocytes In Female Rats Following an Inflammatory Stimulus  

E-Print Network [OSTI]

------+ + + + + + + + + - - - + + + - - - MMP- 2 #0;? * Optica l Density Control Control+LPS Control+EtOH Control+LPS+EtOH Optica l Density Fig 6. MMP-2 lytic activity decreases in astrocytes derived from reproductive senescent female rats. LPS decreased MMP-2 lytic activity...

Simpson, Ashley

2009-09-30T23:59:59.000Z

315

Rat injury model under controlled field-relevant primary blast conditions: Acute response to a wide  

E-Print Network [OSTI]

1 1 Rat injury model under controlled field-relevant primary blast conditions: Acute response.edu Keywords: Traumatic Brain Injury, Primary Blast, Mortality, Cellular Membrane Permeability, Lung Injury the risk of sustaining blast induced injury by military personnel and civilians. The blast injury

Farritor, Shane

316

A Glucose BioFuel Cell Implanted in Rats Philippe Cinquin1  

E-Print Network [OSTI]

A Glucose BioFuel Cell Implanted in Rats Philippe Cinquin1 *, Chantal Gondran2 , Fabien Giroud2 powerful ones, Glucose BioFuel Cells (GBFCs), are based on enzymes electrically wired by redox mediators applications. Citation: Cinquin P, Gondran C, Giroud F, Mazabrard S, Pellissier A, et al. (2010) A Glucose BioFuel

Paris-Sud XI, Université de

317

Imaging Oxygen Consumption in Forepaw Somatosensory Stimulation in Rats Under Isoflurane Anesthesia  

E-Print Network [OSTI]

Imaging Oxygen Consumption in Forepaw Somatosensory Stimulation in Rats Under Isoflurane Anesthesia consumption, indicative of partial coupling of CBF and CMRO2. This study describes a useful forepaw. Following Fox et al.'s (2) initial study with positron emission tomography (PET), stimulus- evoked CMRO2

Duong, Timothy Q.

318

Diffuse Optical Tomography of Cerebral Blood Flow, Oxygenation, and Metabolism in Rat During Focal Ischemia  

E-Print Network [OSTI]

of oxygen consumption (CMRO2). Temporary (60-minute) MCAO was performed on five rats. Ischemic changes--Cerebral metabolic rate of oxygen consumption. Diffuse optical tomography (DOT) of the brain is an attractive new complementary to those of magnetic resonance imaging (MRI) and positron emission tomog- raphy (PET), and holds

Yodh, Arjun G.

319

anticoagulant-susceptible norway rats: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

anticoagulant-susceptible norway rats First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Assessing the...

320

Effect of fermentable carbohydrates on volatile fatty acids, ammonia and mineral absorption in the rat caecum  

E-Print Network [OSTI]

intestine on caecal digestion and absorption have been studied in the rat. Even in diets lacking these carbo of the urea nitrogen was used in bacterial protein synthesis. Arteriovenous differences in the caecum showed, for which hydrolysing enzymes are lacking or poorly efficient in the small i ntesti ne. These carbohydrates

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

UPTAKE OF [3H]-COLCHICINE INTO BRAIN AND LIVER OF MOUSE, RAT, AND CHICK  

E-Print Network [OSTI]

by M.R. Rosenzweig and E.l. Bennett, Cambridge, MA: The MITJ.F. , D.W. landry, E.l. Bennett, and M.E. Jarvik. long-termRAT,AND CHICK Edward L. Bennett, Marie Hebert Alberti, and

Bennett, Edward L.

2010-01-01T23:59:59.000Z

322

Inhalation developmental toxicology studies: Teratology study of acetone in mice and rats: Final report  

SciTech Connect (OSTI)

Acetone, an aliphatic ketone, is a ubiquitous industrial solvent and chemical intermediate; consequently, the opportunity for human exposure is high. The potential for acetone to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 440, 2200, or 11000 ppm, and in Swiss (CD-1) mice exposed to 0, 440, 2200, and 6600 ppm acetone vapors, 6 h/day, 7 days/week. Each of the four treatment groups consisted of 10 virgin females (for comparison), and approx.32 positively mated rats or mice. Positively mated mice were exposed on days 6-17 of gestation (dg), and rats on 6-19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 46 refs., 6 figs., 27 tabs.

Mast, T.J.; Evanoff, J.J.; Rommereim, R.L.; Stoney, K.H.; Weigel, R.J.; Westerberg, R.B.

1988-11-01T23:59:59.000Z

323

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing rats  

E-Print Network [OSTI]

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing-Chomponelle, Theix, 63110 Beaumont, France. Summary. (1) Magnesium deficiency was induced in Sprague-Dawley male rats of deprivation. (3) The leg bones were fragmented as shown in figure 1. Their magnesium content had decreased

Paris-Sud XI, Université de

324

Effect of dietary baobab oil on the hepatic ?-9 desaturase in the rat.  

E-Print Network [OSTI]

baobab seed oil (BO) or heated baobab oil (HBO) or a mixture of palm and sun- flower oils (MO). HeatEffect of dietary baobab oil on the hepatic ?-9 desaturase in the rat. JP Blond A Andrianaivo- seille Cedex 13, France) Refined baobab seed oil is consumed by the Mal- agasy population (inhabitants

Boyer, Edmond

325

Regulation of metabolism during lactation in the rat D. H. WILLIAMSON  

E-Print Network [OSTI]

the lactose and protein and a high proportion of the lipid con- tained in rat milk are synthesized within, in particular, milk production, appears to depend on two hormo- nes, prolactin and insulin. Secretion responsible for regula- tion of insulin secretion from the pancreas. The apparent paradox in lactation

Boyer, Edmond

326

Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading to  

E-Print Network [OSTI]

Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which

Paris-Sud XI, Université de

327

Gender Differences in Transcriptional Signature of Developing Rat Testes and Ovaries following Embryonic  

E-Print Network [OSTI]

Dioxins are persistent organic pollutants interfering with endocrine systems and causing reproductive,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) on reproductive function of male and female offspring in the rat with a special fertility of the progeny. We choose a global gene expression approach using Affymetrix microarray analysis

Paris-Sud XI, Université de

328

5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats  

E-Print Network [OSTI]

- hydroxy-L-tryptophan (5-HTP), serotonin's immediate intracellular precursor, has been thought inhibitor to protect 5-HTP from destruction outside the brain. We have examined the effect of 5-HTP on food consumption and tissue 5-HTP levels among rats subjected to two different hyperphagic stimuli, food

Wurtman, Richard

329

A study of the effect of restricted diets in the male albino rat  

E-Print Network [OSTI]

CLon exxpertment metabolic rate was also osti mated by means ?f serum clearance of radioactive I?dine. This determination was ne during tho twenty fourth week of the superi ment on five animals from each Creatment group. Each rat was infected intraperitoneally...

Griffin, Travis Barton

1961-01-01T23:59:59.000Z

330

Induced Hypothermia During Resuscitation from Hemorrhagic Shock Attenuates Microvascular Inflammation in the Rat Mesenteric Microcirculation  

E-Print Network [OSTI]

INDUCED HYPOTHERMIA DURING RESUSCITATION FROM HEMORRHAGIC SHOCK ATTENUATES MICROVASCULAR INFLAMMATION IN THE RAT MESENTERIC MICROCIRCULATION BY GARRETT NICHOLAS COYAN BS, UNIVERSITY OF MICHIGAN, 2009 Submitted to the graduate degree... program in Clinical Research and the Graduate Faculty of the University of Kansas in partial fulfillment of the requirements for the degree of Master of Science. ________________________________ Chairperson Edward F. Ellerbeck, MD, MPH...

Coyan, Garrett Nicholas

2013-08-31T23:59:59.000Z

331

Grid Cells and Theta as Oscillatory Interference: Electrophysiological Data From Freely Moving Rats  

E-Print Network [OSTI]

Grid Cells and Theta as Oscillatory Interference: Electrophysiological Data From Freely Moving Rats, regular firing patterns by medial entorhinal cortical (mEC) grid cells in terms of the interference specific relationships between the intrinsic firing frequency and spa- tial scale of grid cell firing

Burgess, Neil

332

Polycyclic Aromatic Hydrocarbons Present in Cigarette Smoke Cause Bone Loss in an Ovariectomized Rat Model  

E-Print Network [OSTI]

of epidemiological studies have suggested that cigarette smoking is a risk factor for osteoporosis. Benzo- (a and fragility seen in smoking-related osteoporosis. In this study four groups of 9-month-old Sprague-Dawley rats; Ovariectomy (ovx); Estrogen; Osteoporosis. Introduction Epidemiological studies have focused

Waldman, Stephen D.

333

Some histological manifestations in the vitamin B b12 sdeficient newborn rat  

E-Print Network [OSTI]

&dna;, . and spieen 1n duced by a materw?l v1tamin Rl? deficiency 1? the ?suborn albino rat, 4 secondary porno a Ips to co"lpga e the '?Jot'. , +t dif faro loca bot'i&en the hearts, livorn and '. . Tdnevs of novborn offspring oi' v'to oin Q2 deficient mothers...

Jones, Carroll Christian

1954-01-01T23:59:59.000Z

334

Effects of dietary fat, fiber and carcinogen on fecal diacylglcyerols in the rat  

E-Print Network [OSTI]

of physiological modifiers such as diet and carcinogen on fecal DAG mass and composition have not been reported. We designed a 2 x 2 x 2 factorial study (2 fats: corn oil 'I and fish oil; 2 fibers: pectin and 'Cellulose; with and without carcinogen). Rats were...

Pickering, Jennifer Sharon

1996-01-01T23:59:59.000Z

335

Activation of calcium-sensing receptor increases TRPC3 expression in rat cardiomyocytes  

SciTech Connect (OSTI)

Research highlights: {yields} Calcium-sensing receptor (CaR) activation stimulates TRP channels. {yields} CaR promoted transient receptor potential C3 (TRPC3) expression. {yields} Adult rat ventricular myocytes display capacitative calcium entry (CCE), which was operated by TRPCs. {yields} TRPC channels activation induced by CaR activator sustained the increased [Ca{sup 2+}]{sub i} to evoke cardiomyocytes apoptosis. -- Abstract: Transient receptor potential (TRP) channels are expressed in cardiomyocytes, which gate a type of influx of extracellular calcium, the capacitative calcium entry. TRP channels play a role in mediating Ca{sup 2+} overload in the heart. Calcium-sensing receptors (CaR) are also expressed in rat cardiac tissue and promote the apoptosis of cardiomyocytes by Ca{sup 2+} overload. However, data about the link between CaR and TRP channels in rat heart are few. In this study, reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting were used to examine the expression of the TRP canonical proteins TRPC1 and TRPC3 in adult and neonatal rat cardiomyocytes. Laser scan confocal microscopy was used to detect intracellular [Ca{sup 2+}]{sub i} levels in isolated adult rat ventricular myocytes. The results showed that, in adult rat cardiomyocytes, the depletion of Ca{sup 2+} stores in the endoplasmic/sarcoplasmic reticulum (ER/SR) by thapsigargin induced a transient increase in [Ca{sup 2+}]{sub i} in the absence of [Ca{sup 2+}]{sub o} and the subsequent restoration of [Ca{sup 2+}]{sub o} sustained the increased [Ca{sup 2+}]{sub i} for a few minutes, whereas, the persisting elevation of [Ca{sup 2+}]{sub i} was reduced in the presence of the TRPC inhibitor SKF96365. The stimulation of CaR by its activator gadolinium chloride (GdCl{sub 3}) or spermine also resulted in the same effect and the duration of [Ca{sup 2+}]{sub i} increase was also shortened in the absence of [Ca{sup 2+}]{sub o}. In adult and neonatal rat cardiomyocytes, GdCl{sub 3} increased the expression of TRPC3 mRNA and protein, which were reversed by SKF96365 but not by inhibitors of the L-type channels and the Na{sup +}/Ca{sup 2+} exchangers. However, GdCl{sub 3} had no obvious effect on the expression of TRPC1 protein. These results suggested that CaR stimulation induced activation of TRP channels and promoted the expression of TRPC3, but not TRPC1, that sustained the increased [Ca{sup 2+}]{sub i}.

Feng, Shan-Li [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Sun, Ming-Rui [Department of Pharmacology, Qiqihaer Medical College, Qiqihaer 160001 (China)] [Department of Pharmacology, Qiqihaer Medical College, Qiqihaer 160001 (China); Li, Ting-Ting; Yin, Xin [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Xu, Chang-Qing [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China)] [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Sun, Yi-Hua, E-mail: syh200415@126.com [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)

2011-03-11T23:59:59.000Z

336

Studies on Pentoxifylline and Tocopherol Combination for Radiation-Induced Heart Disease in Rats  

SciTech Connect (OSTI)

Purpose: To investigate whether the application of pentoxifylline (PTX) and tocopherol l (Vit. E) could modify the development of radiation-induced heart disease and downregulate the expression of transforming growth factor (TGF)-{beta}1mRNA in rats. Methods and Materials: A total of 120 Sprague-Dawley rats were separated into four groups: control group, irradiated group, experimental group 1, and experiment group 2. Supplementation was started 3 days before irradiation; in experimental group 1, injection of PTX (15 mg/kg/d) and Vit. E (5.5 mg/kg/d) continued till the 12th week postirradiation, whereas in experimental group 2 it was continued until the 24th week postirradiation. All rats were administrated a single dose of 20 Gy irradiation to the heart except the control group. Histopathologic evaluation was performed at various time points (Days 1, 2, 4, 8, and 12 and 24th week) up to 24 weeks after irradiation. Changes of levels of TGF-{beta}1 mRNA expression were also investigated at the same time points using competitive polymerase chain reaction. Results: Compared with the irradiated group, levels of TGF-{beta}1 mRNA of the rat hearts were relatively low in the two experimental groups on the 12th week postirradiation. In experimental group 1, there was a rebound expression of TGF-{beta}1 mRNA on the 24th week postirradiation, whereas that of the experimental group 2 remained low (p < 0.05). The proportions of collagen fibers of the two experimental groups were lower than that of irradiated group (p < 0.05). A rebound could be observed in the experimental group 1. Conclusion: PTX and Vit. E downregulated the expression of TGF-{beta}1 mRNA. The irradiated rat hearts showed a marked pathologic response to the drugs. The withdrawal of drugs in the 12th week postirradiation could cause rebound effects of the development of fibrosis.

Liu Hui [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Xiong Mai [Department of Cardiac Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong (China); Xia Yunfei; Cui Nianji; Lu Rubiao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Deng Ling [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Lin Yuehao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Clinical Laboratory, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Rong Tiehua [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China)], E-mail: esophagus2003@yahoo.com.cn

2009-04-01T23:59:59.000Z

337

Myocardial kinetics of carbon-11-epinephrine in the isolated working rat heart  

SciTech Connect (OSTI)

The kinetics of EPI were studied in the isolated rat heart model to evaluate {sup 11}C-epinephrine (EPI) as a radiotracer for the assessment of sympathetic neuronal function in the heart. Isolated rat hearts were perfused in a working mode. Carbon-11-EPI was added to the perfusate during wash-in period of 20 min, followed by a washout period of 40 min. Radioactivity in the heart was externally monitored and time-activity curves were recorded as a function of time. Effluent samples were collected throughout each study to determine the fraction of {sup 11}C radioactivity as intact tracer. Time-activity curves of control hearts showed that {sup 11}C-EPI is taken up and retained by the myocardium. Desipramine inhibition (DMI) of uptake-1 resulted in a significant decrease in myocardial uptake and retention of {sup 11}C-EPI by 91% compared to controls. Addition of DMI to the perfusion medium during washout did not affect kinetics of {sup 11}C-EPI compared to control hearts. Reserpine pretreated rat hearts also showed significant decrease in tracer retention of 95% compared to controls. The metabolic data showed that, in control conditions, about 61% of {sup 11}C-EPI taken up by the rat heart is rapidly metabolized and released. Carbon-11-EPI traces sympathetic nerve terminals in the isolated rat heart. Uptake blockade by DMI and reserpine suggest that uptake and storage of {sup 11}C-EPI appear to be similar to that of norepinephrine. However, the prominent metabolic pathway warrants further consideration. These results suggest that {sup 11}C-EPI may be a suitable radiolabeled tracer for the evaluation of sympathetic vesicular function of the heart by PET. 23 refs., 3 figs., 3 tabs.

Nguyen, N.T.B.; DeGrado, T.R.; Chakraborty, P. [Univ. of Michigan, Ann Arbor, MI (United States)] [and others

1997-05-01T23:59:59.000Z

338

Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats  

SciTech Connect (OSTI)

Highlights: ? Propofol, as a model anesthetic drug, induced whole body insulin resistance. ? Propofol anesthesia decreased glucose infusion rate to maintain euglycemia. ? Propofol decreased insulin-mediated glucose uptake in skeletal and cardiac muscles. ? Propofol increased hepatic glucose output confirming hepatic insulin resistance. -- Abstract: Hyperglycemia together with hepatic and muscle insulin resistance are common features in critically ill patients, and these changes are associated with enhanced inflammatory response, increased susceptibility to infection, muscle wasting, and worsened prognosis. Tight blood glucose control by intensive insulin treatment may reduce the morbidity and mortality in intensive care units. Although some anesthetics have been shown to cause insulin resistance, it remains unknown how and in which tissues insulin resistance is induced by anesthetics. Moreover, the effects of propofol, a clinically relevant intravenous anesthetic, also used in the intensive care unit for sedation, on insulin sensitivity have not yet been investigated. Euglycemic hyperinsulinemic clamp study was performed in rats anesthetized with propofol and conscious unrestrained rats. To evaluate glucose uptake in tissues and hepatic glucose output [{sup 3}H]glucose and 2-deoxy[{sup 14}C]glucose were infused during the clamp study. Anesthesia with propofol induced a marked whole-body insulin resistance compared with conscious rats, as reflected by significantly decreased glucose infusion rate to maintain euglycemia. Insulin-stimulated tissue glucose uptake was decreased in skeletal muscle and heart, and hepatic glucose output was increased in propofol anesthetized rats. Anesthesia with propofol induces systemic insulin resistance along with decreases in insulin-stimulated glucose uptake in skeletal and heart muscle and attenuation of the insulin-mediated suppression of hepatic glucose output in rats.

Yasuda, Yoshikazu; Fukushima, Yuji; Kaneki, Masao [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States)] [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States); Martyn, J.A. Jeevendra, E-mail: jmartyn@partners.org [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States)] [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States)

2013-02-01T23:59:59.000Z

339

Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury  

E-Print Network [OSTI]

Abstract Background We have previously shown that the slow Wallerian degeneration mutation, whilst delaying axonal degeneration after optic nerve crush, does not protect retinal ganglion cell (RGC) bodies in adult rats. To test the effects of a...

Lorber, Barbara; Tassoni, Alessia; Bull, Natalie D; Moschos, Marilita M; Martin, Keith R

2012-06-06T23:59:59.000Z

340

Redescription of the enigmatic long-tailed rat Sigmodontomys aphrastus (Cricetidae: Sigmodontinae) with comments on taxonomy and natural history  

E-Print Network [OSTI]

Sigmodontomys aphrastus, the long-tailed rat, is an exceedingly rare rodent species from montane regions of Central and South America of which very little is known ecologically or systematically. It has been variously ...

McCain, Christy M.; Timm, Robert M.; Weksler, Marcelo

2007-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

The role of constrictor prostanoids in the development of aortic coarctation-induced hypertension in male and female rats  

E-Print Network [OSTI]

function and arterial blood pressure (MAP) during development of aortic coarctation-induced hypertension (HT). M and F rats, (15-18 wks.) in four groups: normotensive (NT), hypertensive (HT), ovariectomized (OVX), and OVX estrogen-replaced (OE), underwent...

Baltzer, Wendy Irene

2005-02-17T23:59:59.000Z

342

Quantifying the strain response in the rat tibia during simulated resistance training used as a disuse countermeasure  

E-Print Network [OSTI]

loss. This study used a hindlimb unloaded (HU) rat model to simulate microgravity and a muscle stimulation countermeasure to simulate resistive exercise. Uniaxial strain gages were implanted on the antero-medial aspect of the proximal tibia to measure...

Jeffery, Jay Melvin

2009-05-15T23:59:59.000Z

343

Quantifying the strain response in the rat tibia during simulated resistance training used as a disuse countermeasure  

E-Print Network [OSTI]

loss. This study used a hindlimb unloaded (HU) rat model to simulate microgravity and a muscle stimulation countermeasure to simulate resistive exercise. Uniaxial strain gages were implanted on the antero-medial aspect of the proximal tibia to measure...

Jeffery, Jay Melvin

2008-10-10T23:59:59.000Z

344

Effect of dietary protein quality on fractional rates of muscle protein synthesis and catabolism in the rat  

E-Print Network [OSTI]

EFFECT OF DIETARY PROTEIN QUALITY ON FRACTIONAL RATES OF MUSCLE PROTEIN SYNTHESIS AND CATABOLISM IN THE RAT A Thesis by RICHARD ANTHONY ROEDER Submitted to the Graduate College of Texas A8cM University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1979 Major Subject: Animal Nutrition EFFECT OF DIETARY PROTEIN QUALITY ON FRACTIONAL RATES OF MUSCLE PROTEIN SYNTHESIS AND CATABOLISM IN THE RAT A Thesis by RICHARD ANTHONY ROEDER Approved...

Roeder, Richard Anthony

1979-01-01T23:59:59.000Z

345

Opiate activity in the rat prefrontal cortex: modulation of ventral tegmental area dopaminergic influence on cortical efferent neurons  

E-Print Network [OSTI]

OPIATE ACTIVITY IN THE RAT PREFRONTAL CORTEX: MODULATION OF VENTRAL TEGMENTAL AREA DOPAMINERGIC INFLUENCE ON CORTICAL EFFERENT NEURONS A Thesis by JOHN STEVEN ST. MARY Submitted to the Graduate College of Texas A&M University in partial... Thesis by JOHN STEVEN ST. MARY Approved as to style and content by: Steven Peterson (Chairman of Committee) Robert Matthews (- '" j'pj") Ger a ((~Fe g (Mem er) George Chion (Member) December 1986 ABSTRACT Opiate Activity in the Rat...

St. Mary, John Steven

1986-01-01T23:59:59.000Z

346

The effects of a suboptimal intake of magnesium with soy protein concentrate on parturition, growth, and viability in the rat  

E-Print Network [OSTI]

THE EFFECTS OF A SUBOPTIMAL INTAKE OF MAGNESIUM WITH SOY PROTEIN CONCENTRATE ON PARTURITION, GROWTH, AND VIABILITY IN THE RAT A Thesis by SONJA D'AWN CARSON Submitted to the Graduate College of Texas AEM University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE December 1985 Major Subject: Nutrition THE EFFECTS OF A SUBOPTIMAL INTAKE OF MAGNESIUM WITH SOY PROTEIN CONCENTRATE ON PARTURITIONe GROWTH, AND VIABILITY IN THE RAT A Thesis by SONJA D'AWN CARSON...

Carson, Sonja D'Awn

2012-06-07T23:59:59.000Z

347

Short term effects of commercial polychlorinated biphenyl (PCB) mixtures and individual PCB congeners in female Sprague-Dawley rats  

E-Print Network [OSTI]

SHORT TERM EFFECTS OF COMMERCIAL POLYCHLORINATED BIPHENYL (PCB) MIXTURFS AND INDIVIDUAL PCB CONGENERS IN FEMALE SPRAGUE-DAWLEY RATS A Thesis by YU-CHYU CHEN Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1992 Major subject: Toxicology SHORT TERM EFFECTS OF COMMERCIAL POLYCHLORINATED BIPHENYL (PCB) MIXTURES AND INDIVIDUAL PCB CONGENERS IN FEMALE SPRAGUE-DAWLEY RATS A Thesis...

Chen, Yu-Chyu

1992-01-01T23:59:59.000Z

348

The Effects of Habitat Fragmentation on the Behavior of the Cotton Rat (Sigmodon hispidus):Phase II  

SciTech Connect (OSTI)

The authors studied the movements of cotton rats and cotton mice in experimental landscapes at the SRS in order to determine the effects of fragmentation and connectivity between habitat patches on dispersal movements and population dynamics. Densities between connected and isolated patches were not different. Small patches tended to support higher densities. Cotton rats were more common in corridors than expected and cotton mice were more likely to leave by a corridor.

Barrett, G.W.; Drelin, E.A.; Mabry, K.E.

2001-07-01T23:59:59.000Z

349

An investigation of the potentiating effects of ethanol on a chronic exposure of rats to 1,1,1-trichloroethane  

E-Print Network [OSTI]

AN INVESTIGATION OF THE POTENTIATING EFFECTS OF ETHANOL ON A CHRONIC EXPOSURE OF RATS TO 1, 1&I-TRICHLOROETHANE A Thesis by DEWAYNE HAROLD WALKER Submitted to the Graduate College of Texas AFM University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1973 Major Subject: Laboratory Animal Medicine AN INVESTIGATION OF THE POTENTIATING EFFECTS OF ETHANOL ON A CHRONIC EXPOSURE OF RATS TQ 1&1, 1-TRICHLOROETHANE A Thesis by DENAYNE HAROLD WALKER...

Walker, DeWayne Harold

1973-01-01T23:59:59.000Z

350

Blood risk factor metabolites associated with heart disease and myocardial fatty acids in copper-deficient male and female rats  

SciTech Connect (OSTI)

Intact and castrated males and intact and ovariectomized female rats were fed a copper-deficient diet in order to establish whether the protection provided in females against cardiovascular pathology and mortality is due to endogenous sex hormones, and different levels of blood lipids and/or myocardial fatty acids. Seventy-three male and female rats were assigned to a copper-deficient diet (0.6 {mu}g of copper/g diet) containing 62% fructose for 8 weeks. Twelve of the male rats underwent castration and 12 of the females were ovariectomized. All animals exhibited high levels of plasma cholesterol, triglycerides, and uric acid, which were neither affected by the sex of the rat nor by the surgical treatment. The composition of fatty acids of the myocardium was similar in males and females. Except for those animals that were sacrificed by us, all other male rats died of heart pathology. In contrast, none of the female rats exhibited heart pathology and none died of the deficiency. It is suggested that heart pathology and mortality in copper deficiency are sex related and not due to high levels of plasma cholesterol, triglycerides, and uric acid or to differences in myocardial fatty acid composition.

Fields, M.; Lewis, C.; Beal, T. (Georgetown Univ. Medical School, WA (USA)); Berlin, E.; Kliman, P.G.; Peters, R.C. (Department of Agriculture, Beltsville, MD (USA))

1989-07-01T23:59:59.000Z

351

Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-? expression  

SciTech Connect (OSTI)

Dyslipidemia is common in patients with diabetes mellitus (DM) and is considered a risk factor for the progression of diabetic nephropathy (DN). Hyperlipidemia and hyperglycemia act synergistically to induce renal injury. The present study was designed to investigate the protective effects of tocotrienols as tocotrienol-rich fraction (TRF) extracted from palm (PO) and rice bran oils (RBO) against lipid induced nephropathy in type-2 diabetic rats and its probable molecular mechanism. Male Wistar rats (175–200 g) were divided into four groups. The first group served as diabetic control, while the second and third groups received PO-TRF and RBO-TRF, respectively by gavage over a period of sixteen weeks post-induction of diabetes. The fourth group comprised of age-matched rats that served as normal control. The effects of TRF on serum lipid profile, oxidative stress markers, expression of TGF-?, fibronectin and collagen type IV were analyzed in the kidney of diabetic rats. Treatment with PO-TRF and RBO-TRF significantly improved glycemic status, serum lipid profile and renal function in type-2 diabetic rats. In addition, TRF supplementation down-regulated the expression of TGF-?, fibronectin and collagen type IV in the kidney of diabetic rats. Transforming growth factor-? (TGF-?) plays a critical role in progression of DN, but its modulation by tocotrienols in DN remains unexplored. TRF ameliorated lipid induced nephropathy in type-2 diabetes by its hypoglycemic, hypolipidemic and antioxidant activities as well as by modulation of TGF-? to prevent increased expression of collagen type IV and fibrinogen. We finally propose a mechanism for the expression of molecular markers that are significant in the events leading to diabetic nephropathy and its modulation by tocotrienols/TRF. - Highlights: • The nephroprotective effect of TRF in type-2 diabetic rats was investigated. • Treatment with TRF improved glycemic status, lipid profile and renal functions in rats. • TRF down-regulated the expression of TGF-?, fibronectin and collagen in rats' kidney. • TRF ameliorated nephropathy by hypoglycemic, hypolipidemic and antioxidant activity. • Tocotrienols modulate the expression of TGF-? in DN in type-2 diabetic rats.

Siddiqui, Shabeena [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India); Ahsan, Haseeb [Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, New Delhi 110025 (India); Khan, Mohammad Rashid [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India); Siddiqui, Waseem A., E-mail: wasiddiqui01@gmail.com [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India)

2013-12-01T23:59:59.000Z

352

Effect of freezing on the coupling of VIP receptors to adenylate cyclase in rat liver membranes  

SciTech Connect (OSTI)

In fresh rat liver plasma membranes high affinity VIP receptors were specifically labelled with (/sup 125/I) helodermin and were well coupled to adenylate cyclase while low affinity VIP receptors were not. After freezing and thawing low affinity VIP receptors were also coupled to adenylate cyclase. This modification of adenylate cyclase activation was specific for the VIP response as freezing and thawing did not modify Gpp(NH)p, NaF and glucagon stimulations. 26 references, 3 figures, 1 table.

Robberecht, P.; Waelbroeck, M.; De Neef, P.; Camus, J.C.; Gourlet, P.; Christophe, J.

1988-01-01T23:59:59.000Z

353

Comparative effects of sodium channel blockers in short term rat whole embryo culture  

SciTech Connect (OSTI)

This study was undertaken to examine the effect on the rat embryonic heart of two experimental drugs (AZA and AZB) which are known to block the sodium channel Nav1.5, the hERG potassium channel and the L-type calcium channel. The sodium channel blockers bupivacaine, lidocaine, and the L-type calcium channel blocker nifedipine were used as reference substances. The experimental model was the gestational day (GD) 13 rat embryo cultured in vitro. In this model the embryonic heart activity can be directly observed, recorded and analyzed using computer assisted image analysis as it responds to the addition of test drugs. The effect on the heart was studied for a range of concentrations and for a duration up to 3 h. The results showed that AZA and AZB caused a concentration-dependent bradycardia of the embryonic heart and at high concentrations heart block. These effects were reversible on washout. In terms of potency to cause bradycardia the compounds were ranked AZB > bupivacaine > AZA > lidocaine > nifedipine. Comparison with results from previous studies with more specific ion channel blockers suggests that the primary effect of AZA and AZB was sodium channel blockage. The study shows that the short-term rat whole embryo culture (WEC) is a suitable system to detect substances hazardous to the embryonic heart. - Highlights: • Study of the effect of sodium channel blocking drugs on embryonic heart function • We used a modified method rat whole embryo culture with image analysis. • The drugs tested caused a concentration dependent bradycardia and heart block. • The effect of drugs acting on multiple ion channels is difficult to predict. • This method may be used to detect cardiotoxicity in prenatal development.

Nilsson, Mats F, E-mail: Mats.Nilsson@farmbio.uu.se [Department of Pharmaceutical Biosciences, Uppsala University (Sweden); Sköld, Anna-Carin; Ericson, Ann-Christin; Annas, Anita; Villar, Rodrigo Palma [AstraZeneca R and D Södertälje (Sweden); Cebers, Gvido [AstraZeneca R and D, iMed, 141 Portland Street, Cambridge, MA 02139 (United States); Hellmold, Heike; Gustafson, Anne-Lee [AstraZeneca R and D Södertälje (Sweden); Webster, William S [Department of Anatomy and Histology, University of Sydney (Australia)

2013-10-15T23:59:59.000Z

354

X-ray intravital microscopy for functional imaging in rat hearts using synchrotron radiation coronary microangiography  

SciTech Connect (OSTI)

An X-ray intravital microscopy technique was developed to enable in vivo visualization of the coronary, cerebral, and pulmonary arteries in rats without exposure of organs and with spatial resolution in the micrometer range and temporal resolution in the millisecond range. We have refined the system continually in terms of the spatial resolution and exposure time. X-rays transmitted through an object are detected by an X-ray direct-conversion type detector, which incorporates an X-ray SATICON pickup tube. The spatial resolution has been improved to 6 {mu}m, yielding sharp images of small arteries. The exposure time has been shortened to around 2 ms using a new rotating-disk X-ray shutter, enabling imaging of beating rat hearts. Quantitative evaluations of the X-ray intravital microscopy technique were extracted from measurements of the smallest-detectable vessel size and detection of the vessel function. The smallest-diameter vessel viewed for measurements is determined primarily by the concentration of iodinated contrast material. The iodine concentration depends on the injection technique. We used ex vivo rat hearts under Langendorff perfusion for accurate evaluation. After the contrast agent is injected into the origin of the aorta in an isolated perfused rat heart, the contrast agent is delivered directly into the coronary arteries with minimum dilution. The vascular internal diameter response of coronary arterial circulation is analyzed to evaluate the vessel function. Small blood vessels of more than about 50 {mu}m diameters were visualized clearly at heart rates of around 300 beats/min. Vasodilation compared to the control was observed quantitatively using drug manipulation. Furthermore, the apparent increase in the number of small vessels with diameters of less than about 50 {mu}m was observed after the vasoactive agents increased the diameters of invisible small blood vessels to visible sizes. This technique is expected to offer the potential for direct investigation of mechanisms of vascular dysfunctions.

Umetani, K. [Japan Synchrotron Radiation Research Institute, SPring-8, Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Fukushima, K. [National Cerebral and Cardiovascular Center Hospital, Fujishirodai, Suita-shi, Osaka 565-8565 (Japan)

2013-03-15T23:59:59.000Z

355

Iron supplementation at high altitudes induces inflammation and oxidative injury to lung tissues in rats  

SciTech Connect (OSTI)

Exposure to high altitudes is associated with hypoxia and increased vulnerability to oxidative stress. Polycythemia (increased number of circulating erythrocytes) develops to compensate the high altitude associated hypoxia. Iron supplementation is, thus, recommended to meet the demand for the physiological polycythemia. Iron is a major player in redox reactions and may exacerbate the high altitudes-associated oxidative stress. The aim of this study was to explore the potential iron-induced oxidative lung tissue injury in rats at high altitudes (6000 ft above the sea level). Iron supplementation (2 mg elemental iron/kg, once daily for 15 days) induced histopathological changes to lung tissues that include severe congestion, dilatation of the blood vessels, emphysema in the air alveoli, and peribronchial inflammatory cell infiltration. The levels of pro-inflammatory cytokines (IL-1?, IL-6, and TNF-?), lipid peroxidation product and protein carbonyl content in lung tissues were significantly elevated. Moreover, the levels of reduced glutathione and total antioxidant capacity were significantly reduced. Co-administration of trolox, a water soluble vitamin E analog (25 mg/kg, once daily for the last 7 days of iron supplementation), alleviated the lung histological impairments, significantly decreased the pro-inflammatory cytokines, and restored the oxidative stress markers. Together, our findings indicate that iron supplementation at high altitudes induces lung tissue injury in rats. This injury could be mediated through excessive production of reactive oxygen species and induction of inflammatory responses. The study highlights the tissue injury induced by iron supplementation at high altitudes and suggests the co-administration of antioxidants such as trolox as protective measures. - Highlights: • Iron supplementation at high altitudes induced lung histological changes in rats. • Iron induced oxidative stress in lung tissues of rats at high altitudes. • Iron increased the levels of IL-1?, IL-6 and TNF-? in lung tissues at high altitudes. • Trolox alleviated the iron-induced histological and biochemical changes to the lungs.

Salama, Samir A., E-mail: salama.3@buckeyemail.osu.edu [High Altitude Research Center, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11751 (Egypt); Department of Pharmacology and GTMR Unit, College of Clinical Pharmacy, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); Omar, Hany A. [Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Maghrabi, Ibrahim A. [Department of Clinical Pharmacy, College of Clinical Pharmacy, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); AlSaeed, Mohammed S. [Department of Surgery, College of Medicine, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); EL-Tarras, Adel E. [High Altitude Research Center, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia)

2014-01-01T23:59:59.000Z

356

The postnatal development of the sex organs in prenatally and early postnatally irradiated male albino rats  

E-Print Network [OSTI]

days of age and a sub- sequent regeneration between 105 and 185 days of age. Beaumont (1962) reported that in males receiving 100r X-rays on gestational day 17. 5, which corresponds very closely with day 18 irradiates in this study, it 41 appeared.... Bagg concludes, "the results so far indicate that gamma-ray irradiation is a physical agent adapted to the study of experimentally produced developmental arrests in mammalian embryos. " Hanson (1922) reported that male albino rats which were...

Ricks, Robert Clinton

1964-01-01T23:59:59.000Z

357

Effects of chronic cadmium exposure on the conditioned reinforcing properties of morphine and fentanyl in rats  

E-Print Network [OSTI]

&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: ck R. Nation (C ir of Committee) Gerald D. Frye (Member) Paul J. Wellman (Member) Paul J. Wellman (Head of Department... the metal (Nation, Livermore, Bratton, & Schenk, 1996). A similar attenuation was shown with repeated cocaine exposure--the development of locomotor sensitization. Rats that received chronic cadmium exposure required more cocaine administration sessions...

Miller, Dennis K

1997-01-01T23:59:59.000Z

358

Effects of Nicotine Exposure on In Vitro Metabolism of Chlorpyrifos in Male Sprague-Dawley Rats  

SciTech Connect (OSTI)

Chlorpyrifos (CPF) is a common organophosphate (OP) insecticide which is metabolized by CYP450s to the neurotoxic metabolite, chlorpyrifos-oxon (CPF-oxon) and a non-toxic metabolite, 3,5,6-trichloro-2-pyridinol (TCP). The objective of this study was to quantify the effect of repeated in vivo nicotine exposures on CPF in vitro metabolism and marker substrate activities in rats. Male Sprague-Dawley rats were dosed subcutaneously with 1 mg nicotine/kg/, for up to 10 days. Animals showed signs of cholinergic crisis after the initial nicotine doses, but exhibited adaptation after a couple days of treatment. Rats were sacrificed on selected days 4 or 24 hr after the last nicotine-treatment. While CYP450 reduced CO spectra were not different across the treatments, the single nicotine dose group showed a 2-fold increase in CYP2E1 marker substrate (p-nitrophenol) activity 24 hr after a single nicotine treatment compared to saline controls. Conversely, repeated nicotine treatments resulted in decreased EROD marker substrate activity 4 hr after the 7th day of treatment. CPF-oxon Vmax and Km did not show significant changes across the different nicotine treatment groups. The Vmax describing the metabolism of CPF to TCP was increased on all groups (days 1, 7, and 10) 24 hr after nicotine treatment but were unchanged 4 hr after nicotine treatment. Results of this in vitro study suggest that repeated nicotine exposure (i.e., from smoking) may result in altered metabolism of CPF. Future in vivo experiments based on these results will be conducted to ascertain the impact of in vivo nicotine exposures on CPF metabolism in rats.

Lee, Sookwang; Busby, Andrea L.; Timchalk, Charles; Poet, Torka S.

2009-01-30T23:59:59.000Z

359

Some histological manifestations in the early postnatal vitamin B?? deficient albino rat  

E-Print Network [OSTI]

rats were slightly smeller in sine. Ilistologically the cortex was reduced in thickness ?nd therefore in total volume There was a considerable increase in intercellular space which was often filled with connective tissue and sometimes blood..., The renal corpus- cles were characterised by an increase in the space between Bowman's capsule and the glomerulus (I~'ig, 7). The loops of Henle in the medul- lary region showed reduoed lumina. The convoluted tubules (pr obably due to the fatty...

Johnson, Elmer Marshall

1955-01-01T23:59:59.000Z

360

Characterizing strain in the proximal rat tibia during electrical muscle stimulation  

E-Print Network [OSTI]

of model EA-06-015SE-120 strain gage (23) . .................................... 16 Figure 8. Schematic diagram of the Wheatstone bridge circuit (23) ................................. 17 Figure 9. Diagram of a hindlimb unloaded rat (17... of the gage increases due to a reduction in cross-sectional area of the grid elements; however, the change in resistance is too small to measure directly. Therefore, the gage is connected to three known resistors in a Wheatstone Bridge circuit, to which...

Vyvial, Brent Aron

2007-09-17T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
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We encourage you to perform a real-time search of NLEBeta
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361

Rat lymphoma cell bioassay for prolactin: observations on its use and comparison with radioimmunoassay  

SciTech Connect (OSTI)

The rat Nb/sub 2/ node lymphoma cell bioassay (BA) for prolactin (PRL) was validated for use in our laboratories. During the course of this validation we observed that rat prolactin (NIAMDD-RP-1) stimulated cell division by as much as 16.5 fold over the range of 0.04 to 40.0 ng/ml at the end of 72 hours of incubation. We also observed a dose related increase in the size of the lymphoma cells. Prolactin concentrations in rat plasma, serum, anterior pituitary (AP) homogenates and milk were measured by both radioimmunoassay (RIA) and BA. In individual BA's there was parallelism between samples and standard; but when several dilutions of the same plasma and pituitary homogenates were assayed repeatedly, higher PRL levels were consistently observed for the more concentrated samples. At low or moderate levels of plasma PRL there was excellent agreement between RIA and BA; however, at high levels plasma PRL bioactivity exceeded radioimmunoactivity by a small, but significant, amount. A comparison of pituitary PRL concentrations measured by RIA and BA were in good agreement when homogenization was done at pH 10.6. However, when homogenization was done at pH 7.6, slightly but significantly more PRL was extracted when assayed by BA than when assayed by RIA.

Dawson, D.M.; Sensui, N.; Haisenleder, D.H.; Gala, R.R.

1982-12-27T23:59:59.000Z

362

Physiological effects following administration of Citrus aurantium for 28 days in rats  

SciTech Connect (OSTI)

Background: Since ephedra-containing dietary supplements were banned from the US market, manufacturers changed their formulations by eliminating ephedra and replacing with other botanicals, including Citrus aurantium, or bitter orange. Bitter orange contains, among other compounds, synephrine, a chemical that is chemically similar to ephedrine. Since ephedrine may have cardiovascular effects, the goal of this study was to investigate the cardiovascular effects of various doses of bitter orange extract and pure synephrine in rats. Method: Female Sprague–Dawley rats were dosed daily by gavage for 28 days with synephrine from two different extracts. One extract contained 6% synephrine, and the other extract contained 95% synephrine. Doses were 10 or 50 mg synephrine/kg body weight from each extract. Additionally, caffeine was added to these doses, since many dietary supplements also contain caffeine. Telemetry was utilized to monitor heart rate, blood pressure, body temperature and QT interval in all rats. Results and conclusion: Synephrine, either as the bitter orange extract or as pure synephrine, increased heart rate and blood pressure. Animals treated with 95% synephrine showed minimal effects on heart rate and blood pressure; more significant effects were observed with the bitter orange extract suggesting that other components in the botanical can alter these physiological parameters. The increases in heart rate and blood pressure were more pronounced when caffeine was added. None of the treatments affected uncorrected QT interval in the absence of caffeine.

Hansen, Deborah K., E-mail: deborah.hansen@fda.hhs.gov [Division of Personalized Nutrition and Medicine, U.S. FDA/NCTR, 3900 NCTR Rd., Jefferson, AR 72079 (United States); George, Nysia I. [Division of Personalized Nutrition and Medicine, U.S. FDA/NCTR, 3900 NCTR Rd., Jefferson, AR 72079 (United States)] [Division of Personalized Nutrition and Medicine, U.S. FDA/NCTR, 3900 NCTR Rd., Jefferson, AR 72079 (United States); White, Gene E. [Toxicological Pathology Associates, 3900 NCTR Rd., Jefferson, AR 72079 (United States)] [Toxicological Pathology Associates, 3900 NCTR Rd., Jefferson, AR 72079 (United States); Pellicore, Linda S. [Office of New Drugs, U.S. FDA/Center for Drug Evaluation and Research, 10903 New Hampshire Ave., Silver Spring, MD 20903 (United States)] [Office of New Drugs, U.S. FDA/Center for Drug Evaluation and Research, 10903 New Hampshire Ave., Silver Spring, MD 20903 (United States); Abdel-Rahman, Ali; Fabricant, Daniel [Office of Nutrition, Labeling and Dietary Supplements, U.S. FDA/Center for Food Safety and Nutrition, HFS-810, College Park, MD 20740 (United States)] [Office of Nutrition, Labeling and Dietary Supplements, U.S. FDA/Center for Food Safety and Nutrition, HFS-810, College Park, MD 20740 (United States)

2012-06-15T23:59:59.000Z

363

Intestinal permeability and bacterial translocation following small bowel transplantation in the rat  

SciTech Connect (OSTI)

In addition to its role in absorbing nutrients, the intestinal mucosa provides an important barrier against toxins and bacteria in the bowel lumen. The present study evaluated gut barrier function following orthotopic (in continuity) intestinal grafting in rats. Graft histology, intestinal permeability, and bacterial translocation to the grafted mesenteric lymph nodes, the host's liver, and the host's spleen were assessed on the 3rd, 5th, and 7th postoperative days. The study group received no immunosuppression after allotransplantation. The two control groups included rats with isografts and rats with cyclosporine-treated allografts. On the 7th POD, the study animals had moderate transmural inflammation due to rejection, with normal histology in the isografts and CsA-treated allografts; increased intestinal permeability, measured by urinary excretion of oral 51Cr-EDTA (P less than 0.01); and increased number of bacteria in the MLN and spleen (P less than 0.05). The number of bacteria in the MLN and spleen of the study group positively correlated with the changes in intestinal permeability (P less than 0.05). Rejection of the orthotopic intestinal graft leads to increased intestinal permeability and bacterial translocation from the lumen of the graft to the host's reticuloendothelial system. Measures to improve gut barrier function and antibiotic therapy during rejection episodes may help reduce the incidence of septic complications after intestinal grafting.

Grant, D.; Hurlbut, D.; Zhong, R.; Wang, P.Z.; Chen, H.F.; Garcia, B.; Behme, R.; Stiller, C.; Duff, J. (University of Western Ontario (Canada))

1991-08-01T23:59:59.000Z

364

Immunocompetent syngeneic cotton rat tumor models for the assessment of replication-competent oncolytic adenovirus  

SciTech Connect (OSTI)

Oncolytic adenoviruses as a treatment for cancer have demonstrated limited clinical activity. Contributing to this may be the relevance of preclinical animal models used to study these agents. Syngeneic mouse tumor models are generally non-permissive for adenoviral replication, whereas human tumor xenograft models exhibit attenuated immune responses to the vector. The cotton rat (Sigmodon hispidus) is susceptible to human adenovirus infection, permissive for viral replication and exhibits similar inflammatory pathology to humans with adenovirus replicating in the lungs, respiratory passages and cornea. We evaluated three transplantable tumorigenic cotton rat cell lines, CCRT, LCRT and VCRT as models for the study of oncolytic adenoviruses. All three cells lines were readily infected with adenovirus type-5-based vectors and exhibited high levels of transgene expression. The cell lines supported viral replication demonstrated by the induction of cytopathogenic effect (CPE) in tissue culture, increase in virus particle numbers and assembly of virions seen on transmission electron microscopy. In vivo, LCRT and VCRT tumors demonstrated delayed growth after injection with replicating adenovirus. No in vivo antitumor activity was seen in CCRT tumors despite in vitro oncolysis. Adenovirus was also rapidly cleared from the CCRT tumors compared to LCRT and VCRT tumors. The effect observed with the different cotton rat tumor cell lines mimics the variable results of human clinical trials highlighting the potential relevance of this model for assessing the activity and toxicity of oncolytic adenoviruses.

Steel, Jason C.; Morrison, Brian J.; Mannan, Poonam [Cancer Gene Therapy Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Mark O. Hatfield Clinical Research Center, Room 4-5330, 10 Center Drive, Bethesda, MD 20892-1457, National Institutes of Health, Maryland (United States); Abu-Asab, Mones S. [Ultrastructural Pathology, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Maryland (United States); Wildner, Oliver [Department of Molecular and Medical Virology, Ruhr University Bochum (Germany); Miles, Brian K.; Yim, Kevin C. [Virion Systems, Inc., Rockville, Maryland (United States); Ramanan, Vijay [Cancer Gene Therapy Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Mark O. Hatfield Clinical Research Center, Room 4-5330, 10 Center Drive, Bethesda, MD 20892-1457, National Institutes of Health, Maryland (United States); Prince, Gregory A. [Virion Systems, Inc., Rockville, Maryland (United States); Morris, John C. [Cancer Gene Therapy Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Mark O. Hatfield Clinical Research Center, Room 4-5330, 10 Center Drive, Bethesda, MD 20892-1457, National Institutes of Health, Maryland (United States)], E-mail: jmorris@mail.nih.gov

2007-12-05T23:59:59.000Z

365

Cardiac catecholamines in rats fed copper deficient or copper adequate diets containing fructose or starch  

SciTech Connect (OSTI)

The symptoms of copper (Cu) deficiency are known to be more severe when rats are fed a diet with fructose (F) as the principal carbohydrate. Mortality, in males, due to cardiac abnormalities usually occurs after five weeks of a 62% F, 0.6 ppm Cu deficient diet. These effects are not observed if cornstarch (CS) is the carbohydrate (CHO) source. Studies with F containing diets have shown increased catecholamine (C) turnover rates while diets deficient in Cu result in decreased norepinephrine (N) levels in tissues. Dopamine B-hydroxylase (EC 1.14.17.1) is a Cu dependent enzyme which catalyzes the conversion of dopamine (D) to N. An experiment was designed to investigate the effects of CHO and dietary Cu on levels of three C in cardiac tissue. Thirty-two male and female Sprague-Dawley rats were fed Cu deficient or adequate diets with 60% of calories from F or CS for 6 weeks. N, epinephrine (E) and D were measured by HPLC. Statistical analysis indicates that Cu deficiency tends to decrease N levels, while having the reverse effect on E. D did not appear to change. These findings indicate that Cu deficiency but not dietary CHO can affect the concentration of N and E in rat cardiac tissue.

Scholfield, D.J.; Fields, M.; Beal, T.; Lewis, C.G.; Behall, K.M. (Dept. og Agriculture, Beltsville, MD (USA))

1989-02-09T23:59:59.000Z

366

https://mi3.ncdc.noaa.gov/mi3report/MISC/asos-stations.txt  

National Nuclear Security Administration (NNSA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartmentNationalRestart of the Reviewwill help prepareA ReviewManualREMSCareers

367

PET Imaging of Brain 5-HT1A Receptors in Rat In Vivo with 18F-FCWAY and Improvement by  

E-Print Network [OSTI]

PET Imaging of Brain 5-HT1A Receptors in Rat In Vivo with 18F-FCWAY and Improvement by Successful)cyclohexanecarboxamide) is useful in clinical research with PET for measuring serotonin 1A (5-HT1A) re- ceptor densities in brain applicability to measuring brain regional 5-HT1A receptor densities. Methods: PET of rat head after

Shen, Jun

368

Highly accurate quantification of proton MR spectroscopy in rat brain in vivo at 16.4 T , D. Z. Balla1  

E-Print Network [OSTI]

Highly accurate quantification of proton MR spectroscopy in rat brain in vivo at 16.4 T S-T. Hong1, Minnesota, United States Introduction Localized 1 H MR spectroscopy is an efficient tool capable Wistar rats that were anaesthetized by inhalation of 1.5-2 % concentration of isoflurane. All MR

369

Examples of MathML Stephen M. Watt and Xuehong Li  

E-Print Network [OSTI]

> ∫ mi> C mi> ⅆ mi> ? mi> = ∫ ∂ mi> C mi> mi> ? mi> 2. The law of quadratic reciprocity p q q

Watt, Stephen M.

370

A STUDY OF FISCHER 344 RATS EXPOSED TO SILICA DUST FOR SIX MONTHS AT CONCENTRATIONS OF 0, 2, 10 OR 20 MG / M3.  

SciTech Connect (OSTI)

The major objective of this study was to relate the results of a series of functional tests to the compositional and structural alterations in the rat lung induced by subchronic exposure to silica dust. Fischer-344 rats were exposed for 6 hours/day, 5 days/week for 6 months to either 0, 2, 10, or 20 mg SiO{sub 2}/m{sup 3}. The general appearance of the exposed rats was not different from that of the controls. Interestingly, female rats exposed to silica dust, at all tested concentrations, gained more weight than the controls. The lung weight and the lung-to-body weight ratio was greater in the male rats exposed to the highest concentration of silica dust.

KUTZMAN,R.S.

1984-02-01T23:59:59.000Z

371

Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity  

SciTech Connect (OSTI)

The dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a ligand-dependent transcription-factor, the aryl hydrocarbon receptor (AHR). The Han/Wistar (Kuopio) (H/W) strain shows exceptional resistance to many TCDD-induced toxicities; the LD{sub 50} of > 9600 {mu}g/kg for H/W rats is higher than for any other wild-type mammal known. We previously showed that this resistance primarily results from H/W rats expressing a variant AHR isoform that has a substantial portion of the AHR transactivation domain deleted. Despite this large deletion, H/W rats are not entirely refractory to the effects of TCDD; the variant AHR in these animals remains fully competent to up-regulate well-known dioxin-inducible genes. TCDD-sensitive (Long-Evans, L-E) and resistant (H/W) rats were treated with either corn-oil (with or without feed-restriction) or 100 {mu}g/kg TCDD for either four or ten days. Hepatic transcriptional profiling was done using microarrays, and was validated by RT-PCR analysis of 41 genes. A core set of genes was altered in both strains at all time points tested, including CYP1A1, CYP1A2, CYP1B1, Nqo1, Aldh3a1, Tiparp, Exoc3, and Inmt. Outside this core, the strains differed significantly in the breadth of response: three-fold more genes were altered in L-E than H/W rats. At ten days almost all expressed genes were dysregulated in L-E rats, likely reflecting emerging toxic responses. Far fewer genes were affected by feed-restriction, suggesting that only a minority of the TCDD-induced changes are secondary to the wasting syndrome.

Boutros, Paul C.; Yao, Cindy Q.; Watson, John D.; Wu, Alexander H. [Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto (Canada); Moffat, Ivy D. [Department of Pharmacology and Toxicology, University of Toronto, Toronto (Canada); Prokopec, Stephenie D.; Smith, Ashley B. [Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto (Canada); Okey, Allan B. [Department of Pharmacology and Toxicology, University of Toronto, Toronto (Canada); Pohjanvirta, Raimo, E-mail: raimo.pohjanvirta@helsinki.fi [Laboratory of Toxicology, National Institute for Health and Welfare, Kuopio (Finland); Department of Food Hygiene and Environmental Health, University of Helsinki (Finland)

2011-03-01T23:59:59.000Z

372

Effect of intranasal manganese administration on neurotransmission and spatial learning in rats  

SciTech Connect (OSTI)

The effect of intranasal manganese chloride (MnCl{sub 2}·4H{sub 2}O) exposure on spatial learning, memory and motor activity was estimated in Morris water maze task in adult rats. Three-month-old male Wistar rats received for 2 weeks MnCl{sub 2}·4H{sub 2}O at two doses the following: 0.2 mg/kg b.w. (Mn0.2) or 0.8 mg/kg b.w. (Mn0.8) per day. Control (Con) and manganese-exposed groups were observed for behavioral performance and learning in water maze. ANOVA for repeated measurements did not show any significant differences in acquisition in the water maze between the groups. However, the results of the probe trial on day 5, exhibited spatial memory deficits following manganese treatment. After completion of the behavioral experiment, the regional brain concentrations of neurotransmitters and their metabolites were determined via HPLC in selected brain regions, i.e. prefrontal cortex, hippocampus and striatum. ANOVA demonstrated significant differences in the content of monoamines and metabolites between the treatment groups compared to the controls. Negative correlations between platform crossings on the previous platform position in Southeast (SE) quadrant during the probe trial and neurotransmitter turnover suggest that impairment of spatial memory and cognitive performance after manganese (Mn) treatment is associated with modulation of the serotonergic, noradrenergic and dopaminergic neurotransmission in the brain. These findings show that intranasally applied Mn can impair spatial memory with significant changes in the tissue level and metabolism of monoamines in several brain regions. -- Highlights: ? Intranasal exposure to manganese in rats impairs spatial memory in the water maze. ? Regional changes in levels of neurotransmitters in the brain have been identified. ? Cognitive disorder correlates with modulation of 5-HT, NA and DA neurotransmission.

Blecharz-Klin, Kamilla; Piechal, Agnieszka; Joniec-Maciejak, Ilona; Pyrzanowska, Justyna; Widy-Tyszkiewicz, Ewa, E-mail: etyszkiewicz@wum.edu.pl

2012-11-15T23:59:59.000Z

373

RatBot: anti-enumeration peer-to-peer botnets  

SciTech Connect (OSTI)

Botnets have emerged as one of the most severe cyber threats in recent years. To obtain high resilience against a single point of failure, the new generation of botnets have adopted the peer-to-peer (P2P) structure. One critical question regarding these P2P botnets is: how big are they indeed? To address this question, researchers have proposed both actively crawling and passively monitoring methods to enumerate existing P2P botnets. In this work, we go further to explore the potential strategies that botnets may have to obfuscate their true sizes. Towards this end, this paper introduces RatBot, a P2P botnet that applies some statistical techniques to defeat existing P2P botnet enumeration methods. The key ideas of RatBot are two-fold: (1) there exist a fraction of bots that are indistinguishable from their fake identities, which are spoofing IP addresses they use to hide themselves; (2) we use a heavy-tailed distribution to generate the number of fake identities for each of these bots so that the sum of observed fake identities converges only slowly and thus has high variation. We use large-scale high-fidelity simulation to quantify the estimation errors under diverse settings, and the results show that a naive enumeration technique can overestimate the sizes of P2P botnets by one order of magnitude. We believe that our work reveals new challenges of accurately estimating the sizes of P2P botnets, and hope that it will raise the awareness of security practitioners with these challenges. We further suggest a few countermeasures that can potentially defeat RatBot's anti-enumeration scheme.

Yan, Guanhua [Los Alamos National Laboratory; Eidenbenz, Stephan [Los Alamos National Laboratory; Chen, Songqing [GEORGE MASON UNIV.

2010-01-01T23:59:59.000Z

374

The effects of a marginal intake of magnesium with soy protein concentrate on growth, gestation, and lactation in the rat  

E-Print Network [OSTI]

THE EFFECTS OF A MARGINAL INTAKE OF MAGNESIUM WITH SOY PROTEIN CONCENTRATE ON GROWTH, GESTATION, AND LACTATION IN THE RAT A Thesis by CYNTHIA ANNE MCLAUGHLIN Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE May 19B6 Major Subject: Nutrrtion THE EFFECTS OF A MARGINAL INTAKE OF MAGNESIUM WITH SOY PROTEIN CONCENTRATE ON GROWTH, GESTATION, AND LACTATION IN THE RAT A Thesis by CYNTHIA ANNE MCLAUGHLIN Approved...

McLaughlin, Cynthia Anne

2012-06-07T23:59:59.000Z

375

The effect of a prolonged magnesium restriction on the humoral immune response in maternal rats and their offspring  

E-Print Network [OSTI]

TIIE EFFECT 0F A PR0L0NGED MAGNESIUM RESTRI CTI0N ON THE HUMORAL IMMUNE RESPONSE IN HATERHAL RATS AHD THEIR OFFSPRING A Thesis by DIANE T. COHILL Submitted to the Graduate College of Texas ASM University in Partial fulfillment... of the requirements for the degree of MASTER OF SC IENCE May 1987 Major Subject: Nutrition THE EFFECT OF A PROLONGED MAGNESIUM RESTRICTION ON THE HUMORAL IMMUNE RESPONSE IN MATERNAL RATS AND THEIR OFFSPRING A Thesis by DIANE T. COHILL Approved as to sty le...

Cohill, Diane T

2012-06-07T23:59:59.000Z

376

Effects of dietary fat and fiber on the oxidative status of the small intestine and colon of rats  

E-Print Network [OSTI]

EFFECTS OF DIETARY FAT AND FIBER ON THE OXIDATIVE STATUS OF THE SMALL INTESTINE AND COLON OF RATS A Dissertation by LISA MERLE SANDERS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... and Fiber on the Oxidative Status of the Small Intestine and Colon of Rats. (May 2005) Lisa Merle Sanders, B.S., Texas A&M University Chair of Advisory Committee: Dr. Joanne R. Lupton Colon cancer is one of the most commonly diagnosed cancers...

Sanders, Lisa Merle

2006-08-16T23:59:59.000Z

377

The effects of chronic dietary cobalt exposure on behavior and metallothionein levels in the adult rat  

E-Print Network [OSTI]

are often inadequate. Yet, the neurochemical effects of heavy metal exposure do suggest some commonalities. For example, Pb (Shih and Hanin, 1978; Memo et al. , 1980; Silbergeld, 1982), Cd (Rastogi et al. , 1977), and Co (Shibuya et al. , 1978; Hasan... depletions of DA in the basal gang- lia, cerebellum, and brain stem, of' NE in the basal gang- lia, and of 5-HT in the cortex, basal ganglia, and brain stem (Hasan and Ali, 1980). Cobalt has also been shown to decrease GABA levels in rat brains (Shibuya...

Hare, Michael Francis

1983-01-01T23:59:59.000Z

378

A study of the nutritive value of sorghum grain with rats  

E-Print Network [OSTI]

. was conducted to study the digestibility aud nu" ritional uu lity ot serg!rum grain raith rats. Groups c f albiiio cats were fed 10 ~ arleties of so "gb?m grains arid 4 hybrids of. 4 of those varietses with varying sources and levels of amino acids.... . varieties and 4 !iybridc of 4 uf those soc- ghina grain vsr . i ties in this -useazcb i, 'ero fouiid to be i:one!ate~' ly deficie. . t in all ssential rumino acids emcept t. . ucine, bistidir. nd p!ienylalanliie. 1!ie. pro! "in content cf tbe 14 sorghuia...

Dohm, Carolee Kathryn

2012-06-07T23:59:59.000Z

379

Effect of dietary cysteine, methionine, and sterculic acid on fatty acid distribution in rat adipose tissue  

E-Print Network [OSTI]

. Statistical Anal sis The data were treated according to the analysis of variance for data with a single criterion of classifica- tion(24). Each of the ratios for the triglyceride frac- tion were analyzed as: Source oi Variation De rees of Freedom Total... ACIDS IN ADIPOSE TISSUE OF THE RAT B. Free Fatty Acid Fraction Group No. Sterculia f~oa ao 1 Methionine level in diet Cysteine level in diet 16/16:1 18/18:1 18/18:2 18:1/18:2 III IV VI VII VIII 0. 2 0. 2 0. 2 0. 2 low low high...

Brotze, Mary Frances

1968-01-01T23:59:59.000Z

380

Effect of exercise training and dietary fat on rat adipose tissue lipolysis and morphology  

E-Print Network [OSTI]

composition: control (corn oil), diets 1, 2, and 3 [test oil $1 (58. 58 18:2 and 0. 78 18:3 fatty acids), oil $2 (46. 4% 18:2 and 3. 68 18:3 fatty acids), and oil g 3 (55. 7% 18:2 and 18:3 fatty acids), respectively], and diet 4 which was fat...-free. The diets were initiated when the rats were 4 wk old. Body weight (p&0. 001), fat pad weight (p&0. 001), and adipocyte diameter (p&0. 05) were significantly less in the exercised group than in the sedentary group. Adipocyte number was not significantly...

Neale, Sonia Barstad

1989-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Intracranial electrode implantation produces regional neuroinflammation and memory deficits in rats  

SciTech Connect (OSTI)

Deep brain stimulation (DBS) is an established treatment for advanced Parkinson's disease (PD). The procedure entails intracranial implantation of an electrode in a specific brain structure followed by chronic stimulation. Although the beneficial effects of DBS on motor symptoms in PD are well known, it is often accompanied by cognitive impairments, the origin of which is not fully understood. To explore the possible contribution of the surgical procedure itself, we studied the effect of electrode implantation in the subthalamic nucleus (STN) on regional neuroinflammation and memory function in rats implanted bilaterally with stainless steel electrodes. Age-matched sham and intact rats were used as controls. Brains were removed 1 or 8 weeks post-implantation and processed for in vitro autoradiography with [(3)H]PK11195, an established marker of microglial activation. Memory function was assessed by the novel object recognition test (ORT) before surgery and 2 and 8 weeks after surgery. Electrode implantation produced region-dependent changes in ligand binding density in the implanted brains at 1 as well as 8 weeks post-implantation. Cortical regions showed more intense and widespread neuroinflammation than striatal or thalamic structures. Furthermore, implanted animals showed deficits in ORT performance 2 and 8 weeks post-implantation. Thus, electrode implantation resulted in a widespread and persistent neuroinflammation and sustained memory impairment. These results suggest that the insertion and continued presence of electrodes in the brain, even without stimulation, may lead to inflammation-mediated cognitive deficits in susceptible individuals, as observed in patients treated with DBS.

Kuttner-Hirshler, Y.; Biegon, A.; Kuttner-Hirshler, Y.; Polat, U.; Biegon, A.

2009-12-21T23:59:59.000Z

382

Title : Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats.  

E-Print Network [OSTI]

stroke in rats. Yannick Béjota,b,c,d , Anne Tessier a,b , Claire Cachia b , Maurice Giroudb,c,d , Claude in recovery after cerebral ischemia, little is known about cells involved in BDNF production after stroke stroke and that non neuronal-BDNF producing cells differ according to the delay after stroke induction

Paris-Sud XI, Université de

383

Vibrissa Movement Elicited by Rhythmic Electrical Microstimulation to Motor Cortex in the Aroused Rat Mimics Exploratory Whisking  

E-Print Network [OSTI]

Vibrissa Movement Elicited by Rhythmic Electrical Microstimulation to Motor Cortex in the Aroused elicited by rhythmic electrical microstimulation to motor cortex in the aroused rat mimics exploratory.2003. The rhythmic motor activity of the vibrissae that rodents use for the tactile local- ization of objects

Kleinfeld, David

384

The secretion of prolactin (PRL) from pituitary lactotrophs of the rat is predominantly under inhibitory control exerted by  

E-Print Network [OSTI]

The secretion of prolactin (PRL) from pituitary lactotrophs of the rat is predominantly under inhibitory control exerted by dopamine (DA) of hypothalamic origin (1). Other PRL-inhibit- ing substances from the Stojilkovic lab (3) and of this report. In addition to the PRL-inhibiting substances, a host

Bertram, Richard

385

Investigation of Transfer Function Analysis as a Means to Predict Strain on Rat Tibiae from Ankle Torque Waveforms  

E-Print Network [OSTI]

for many years in our lab and others, few researchers have been able to quantify the levels of strain on rat tibiae during EMS and far fewer have investigated the causal relationship between torque produced at the ankle and strain on the tibia. This thesis...

Bouse, Scott

2010-07-14T23:59:59.000Z

386

No age-related cell loss in three retinal nuclear layers of the Long-Evans rat  

E-Print Network [OSTI]

and photoreceptor cells which are distributed in the ganglion cell layer ~GCL!, inner nuclear layer ~INL! and outer. In this study, thus, we wanted to test whether there is an age-related cell loss in the GCL, INL and ONL to INL to GCL was preserved. Keywords: Cell number, Retina, Aging, Long-Evans rat, Stereological method

Zhou, Yi-Feng

387

Beacon Training in a Water Maze Can Facilitate and Compete With Subsequent Room Cue Learning in Rats  

E-Print Network [OSTI]

Beacon Training in a Water Maze Can Facilitate and Compete With Subsequent Room Cue Learning experiments in which rats completed a water-maze blocking procedure, experimental groups were trained to use location. A Room Test (landmarks and background cues only) showed that Stage 1 training with a fixed

Indiana University

388

Integrin Signaling at 2hr and 48hr Post-Eccentric Exercise in Heat Treated Rat Skeletal Muscle  

E-Print Network [OSTI]

and refolding proteins and by maintain actin structures of the cellular membrane. Methods: Heat shocked (HS+EE) and non-heat shocked (EE) male Wistar rats performed a two hour downhill treadmill exercise. The soleus (SOL), vastus lateralis white (VLW) and red...

Graham, Zachary Aaron

2010-07-28T23:59:59.000Z

389

Preweanling Rats Solve the Morris Water Task via Directional Navigation Katherine G. Akers, Felicha T. Candelaria, and Derek A. Hamilton  

E-Print Network [OSTI]

T. Candelaria, and Derek A. Hamilton University of New Mexico Adult rats show a preference (Akers & Hamilton, 2007; Brown & Whishaw, 2000; Carman & Mactutus, 2001; Kraemer & Randall, 1995; Rudy, 1949; Hamilton, Akers, Weisend, & Sutherland, 2007; Skinner et al., 2003)--that may appear behaviorally

Hamilton, Derek

390

Changes in histamine and white blood cells in the blood, spleen and thymus of magnesium-deficient rat  

E-Print Network [OSTI]

Changes in histamine and white blood cells in the blood, spleen and thymus of magnesium of rats were given either a control or a magnesium-deficient diet. The well-known allergy-like crisis, characterized by vasodilatation with redness of the ears and dermatosis, occurred spontaneously in the magnesium

Paris-Sud XI, Université de

391

Hormonal regulation of Sertoli cell function in the rat V. HANSSON, K. PURVIS E. M. RITZN F. S. FRENCH  

E-Print Network [OSTI]

, there have until recently been few attempts to localize the FSH-sensitive target cells. In 1965 MurphyHormonal regulation of Sertoli cell function in the rat V. HANSSON, K. PURVIS E. M. RITZÃ?N F. S of Reproductive Biology, University of North Carolina, Chapel Hill, U. S. A. Summary. The Sertoli cell is the main

Boyer, Edmond

392

EFFECTS OF ANESTHESIA ON NEURAL ACTIVITY IN THE PRIMARY VISUAL CORTEX OF THE RAT Benjamin L. White  

E-Print Network [OSTI]

OF ANESTHESIA ON NEURAL ACTIVITY IN THE PRIMARY VISUAL CORTEX OF THE RAT Benjamin L. White andJózsef Fiser. Recordings were made in six stimulus conditions under four levels of isoflurane anesthesia. Recordings from the same cells across conditions and levels of isoflurane are compared here. Anesthesia ranged from deep

Fiser, József

393

Influence of photoperiod on the time of parturition in the rat. III. Comparison of different daily light lengths with changes  

E-Print Network [OSTI]

Influence of photoperiod on the time of parturition in the rat. III. Comparison of different daily light lengths with changes in light timing or light pulse given during darkness. M. J. BOSC Agnès to the light regime applied throughout pregnancy (day 1 : beginning of pregnancy). The majority of deliveries

Paris-Sud XI, Université de

394

Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts  

SciTech Connect (OSTI)

The calcium-sensing receptor (CaR) is a G-protein coupled receptor that is activated by extracellular calcium (Ca2+o). Rat-1 fibroblasts have been shown to proliferate and increase ERK activity in response to elevation of [Ca2+]o, and these responses are dependent on functional CaR expression. In this report, we examined the role of cross-talk between the CaR and the epidermal growth factor receptor (EGFR) in mediating these responses in Rat-1 cells. This report shows that AG1478, a specific inhibitor of the EGFR kinase, significantly inhibits the increase in proliferation induced by elevated Ca2+o. Further, we show that AG1478 acts downstream or separately from G-protein subunit activation of phospholipase C. AG1478 significantly inhibits Ca2+o-stimulated ERK phosphorylation and in vitro kinase activity. A similar inhibition of ERK phosphorylation was observed in response to the inhibitor AG494. In addition, treatment with inhibitors of metalloproteases involved in shedding of membrane anchored EGF family ligands substantially inhibited the increase in ERK activation in response to elevated Ca2+o. This is consistent with the known expression of TGFa by Rat-1 cells. These results indicate that EGFR transactivation is an important component of the CaR mediated response to increased Ca2+o in Rat-1 fibroblasts, and most likely involves CaR-mediated induction of regulated proteolysis and ligand shedding.

Tomlins, Scott A.; Bollinger, Nikki; Creim, Jeffrey A.; Rodland, Karin D.

2005-08-15T23:59:59.000Z

395

Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4  

E-Print Network [OSTI]

; Carbon tetrachloride; Acute liver injury 1. Introduction Rat TM4SF4 (transmembrane 4 superfamily member 4). Abbreviations: TM4SF4, transmembrane 4 superfamily member 4; CCl4, carbon tetrachloride; ALT, alanine­13]. However, the in vivo function conferred by TM4SF4 is still largely unknown. Carbon tetrachloride (CCl4

Tian, Weidong

396

HumanWildlife Interactions 5(1):100105, Spring 2011 A rat-resistant artificial nest box for  

E-Print Network [OSTI]

Human­Wildlife Interactions 5(1):100­105, Spring 2011 A rat-resistant artificial nest box for cavity-nesting birds WILLIAM C. PITT, USDA/APHIS/Wildlife Services' National Wildlife Research Center elevation areas of the Alakai Plateau. Puaiohi nest primarily on steep streamside cliffs

397

The Effects of Nerve Growth Factor on Spatial Recent Memory in Aged Rats Persist after Discontinuation of Treatment  

E-Print Network [OSTI]

21205 Nerve growth factor (NGF) infusion significantly reduces spatial recent memory deficits in aged examined. Four- and 22-month-old rats were tested preoper- atively, infused intraventricularly with recombinant human NGF or vehicle, and tested both during the 4 week infusion period and during the 4 weeks

Frick, Karyn M.

398

An Age-Dependent Physiologically-Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat  

SciTech Connect (OSTI)

Juvenile rats are more susceptible than adults to the acute toxicity of organophosphorus insecticides like chlorpyrifos (CPF). Age- and dose-dependent differences in metabolism may be responsible. Of importance is CYP450 activation and detoxification of CPF to chlorpyrifos-oxon (CPF-oxon) and trichloropyridinol (TCP), as well as B-esterase (cholinesterase; ChE) and A-esterase (PON-1) detoxification of CPF-oxon to TCP. In the current study, a modified physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model incorporating age-dependent changes in CYP450, PON-1, and tissue ChE levels for rats was developed. In this model, age was used as a dependent function to estimate body weight which was then used to allometrically scale both metabolism and tissue ChE levels. Model simulations suggest that preweanling rats are particularly sensitive to CPF toxicity, with levels of CPF-oxon in blood and brain disproportionately increasing, relative to the response in adult rats. This age-dependent non-linear increase in CPF-oxon concentration may potentially result from the depletion of non-target B-esterases, and a lower PON-1 metabolic capacity in younger animals. These results indicate that the PBPK/PD model behaves consistently with the general understanding of CPF toxicity, pharmacokinetics and tissue ChE inhibition in neonatal and adult rats. Hence, this model represents an important starting point for developing a computational model to assess the neurotoxic potential of environmentally relevant organophosphate exposures in infants and children.

Timchalk, Chuck; Kousba, Ahmed A.; Poet, Torka S.

2007-08-01T23:59:59.000Z

399

The effect of copper deficiency on fetal growth and liver anti-oxidant capacity in the Cohen diabetic rat model  

SciTech Connect (OSTI)

High sucrose low copper diet induces fetal growth restriction in the three strains of the Cohen diabetic rats: an inbred copper deficient resistant (CDr), an inbred copper deficient sensitive (CDs that become diabetic on high sucrose low copper diet -HSD) and an outbred Wistar derived Sabra rats. Although those growth restricted fetuses also exhibit increased oxidative stress, antioxidants do not restore normal growth. In the present study, we evaluated the role of copper deficiency in the HSD induced fetal growth restriction by adding to the drinking water of the rats 1 ppm or 2 ppm of copper throughout their pregnancy. Fetal and placental growth in correlation with fetal liver copper content and anti-oxidant capacity was evaluated on day 21 of pregnancy. HSD compared to regular chow induced fetal growth restriction, which was most significant in the Cohen diabetic sensitive animals. The addition of 1 ppm and 2 ppm copper to the drinking water normalized fetal growth in a dose dependent manner and reduced the degree of hyperglycemia in the diabetes sensitive rats. The CDs fetuses responded to the HSD with lower catalase like activity, and less reduced superoxide dismutase levels compared to the Sabra strain, and had high malondialdehyde levels even when fed regular chow. Immunostaining was higher for nitrotyrosine among the CDr and higher for hypoxia factor 1 ? among the CDs. We conclude that in our model of dietary-induced fetal growth restriction, copper deficiency plays a major etiologic role in the decrease of fetal growth and anti-oxidant capacity. -- Highlights: ? High sucrose low copper diet restricted fetal growth in the Cohen diabetic rat model ? Maternal copper blood levels directly correlated with fetal liver copper content ? Copper supplementation decreased embryonic resorption in the inbred strains ? Copper supplementation reduced hyperglycemia in the sucrose sensitive inbred strain ? Copper supplementation alleviated growth restriction and oxidative stress of liver.

Ergaz, Zivanit, E-mail: zivanit@hadassah.org.il [Hebrew University Hadassah Medical School, Jerusalem (Israel)] [Hebrew University Hadassah Medical School, Jerusalem (Israel); Shoshani-Dror, Dana [Hebrew University Hadassah Medical School, Jerusalem (Israel)] [Hebrew University Hadassah Medical School, Jerusalem (Israel); Guillemin, Claire [Department of Pharmacology and Therapeutics, McGill University, Montreal (Canada)] [Department of Pharmacology and Therapeutics, McGill University, Montreal (Canada); Neeman-azulay, Meytal; Fudim, Liza [Hebrew University Hadassah Medical School, Jerusalem (Israel)] [Hebrew University Hadassah Medical School, Jerusalem (Israel); Weksler-Zangen, Sarah [Diabetes Research Unit, Hebrew University Hadassah Medical School and Hospital, Jerusalem (Israel)] [Diabetes Research Unit, Hebrew University Hadassah Medical School and Hospital, Jerusalem (Israel); Stodgell, Christopher J.; Miller, Richard K. [Department of Obstetrics and Gynecology, University of Rochester, Rochester, MN (United States)] [Department of Obstetrics and Gynecology, University of Rochester, Rochester, MN (United States); Ornoy, Asher [Hebrew University Hadassah Medical School, Jerusalem (Israel)] [Hebrew University Hadassah Medical School, Jerusalem (Israel)

2012-12-01T23:59:59.000Z

400

PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTION FOR A BINARY MIXTURE OF CHLORPYRIFOS AND DIAZINON IN THE RAT  

SciTech Connect (OSTI)

Chlorpyrifos (CPF) and diazinon (DZN) are two commonly used organophosphorus (OP) insecticides and potential exists for concurrent exposures. The primary neurotoxic effects from OP pesticide exposures result from the inhibition of acetylcholinesterase (AChE) by their oxon metabolites. The pharmacokinetic and pharmacodynamic impact of acute binary exposures to CPF and DZN in rats were evaluated in this study. Rats were orally administered CPF, DZN or a CPF/DZN mixture (0, 15, 30 or 60 mg/kg) and blood (plasma and RBC), and brain were collected at 0, 3, 6, 12 and 24 h post-dosing, urine was also collected at 24 h. Chlorpyrifos, DZN and their respective metabolites 3,5,6-trichloro-2-pyridinol (TCP) and 2-isopropyl-4-methyl-6-hydroxypyrimidine (IMHP) were quantified in blood and/or urine and cholinesterase (ChE) inhibition was measured in brain, RBCs and plasma. Co-exposure to CPF/DZN at 15/15 mg/kg, did not appreciably alter the pharmacokinetics of CPF, DZN or their metabolites in blood; whereas, a 60/60 mg/kg dose resulted in a transient increase in Cmax, AUC, and decreased clearance of both compounds, likely due to competition between CPF and DZN for CYP450 metabolism. At lower doses, most likely to be encountered in occupational or environmental exposures, the pharmacokinetics were linear. A dose-dependent inhibition of ChE was noted in tissues for both the single and co-exposures. The overall potency for ChE inhibition was greater for CPF than DZN and the binary mixture response appeared to be strongly influenced by CPF. A comparison of the ChE binary response at the low dose (15 mg/kg), where there were no apparent pharmacokinetic interactions, suggested that the overall ChE response was additive. These are the first reported experiments we are aware of that characterize both the pharmacokinetic and pharmacodynamic interactions between CPF and DZN in the rat, and will be used to further develop a binary physiologically based pharmacokinetic and pharmacodynamic model for mixtures.

Timchalk, Chuck; Poet, Torka S.; Hinman, Melissa N.; Busby, Andrea L.; Kousba, Ahmed A.

2005-05-15T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Luteinizing hormone signaling decreases cyclic GMP production in rat ovarian follicles by rapidly dephosphorylating the NPR2 guanylyl cyclase and by slowly decreasing its agonist CNP  

E-Print Network [OSTI]

Luteinizing hormone signaling decreases cyclic GMP production in rat ovarian follicles by rapidly),place on Millicell culture inserts No LH 20-30 min.LH Homogenize follicles,pellet crude membranes at 10,000 x g

Terasaki, Mark

402

Delay Discounting in Lewis and Fischer 344 Rats: Implications for the Use of an Adjusting-amount Procedure to Detect Between-strain Differences  

E-Print Network [OSTI]

Strain-related behavioral differences may facilitate investigation of the genetic and neurochemical determinants of delay discounting. Previous researchers report that Lewis rats make more impulsive choices than Fischer ...

Stein, Jeff S.

2010-07-21T23:59:59.000Z

403

Differential Effects of HIF-1 Inhibition by YC-1 on the Overall Outcome and Blood-Brain Barrier Damage in a Rat Model of Ischemic Stroke  

E-Print Network [OSTI]

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular adaptation to hypoxia and has been suggested as a potent therapeutic target in cerebral ischemia. Here we show in an ischemic stroke model of rats that ...

Yan, Jingqi; Zhou, Bo; Taheri, Saeid; Shi, Honglian

2011-11-16T23:59:59.000Z

404

Effect of inactivity and passive stretch on protein turnover in phasic and postural rat muscles  

SciTech Connect (OSTI)

Muscle atrophy in humans can occur during prolonged bed rest, plaster cast immobilization, and space flight. In the present study, the suspension model used by Musacchia et al. (1983) is employed to investigate changes in protein synthesis and degradation in fast-twitch phasic (extensor digitorum longus) and slow-twitch postural (soleus) muscles in the rat, following hypokinesia and hypodynamia. In addition, the use of passive stretch was examined as a means of preventing atrophy. The obtained results suggest that the mechanisms controlling the processes of protein synthesis and protein breakdown during muscle disuse atrophy may be independent of each other. It appears, however, that the muscle atrophy due to hypokinesia and hypodynamia can be temporarily prevented by passively stretching a muscle. 38 references.

Loughna, P.; Goldspink, G.; Goldspink, D.F.

1986-07-01T23:59:59.000Z

405

Different antagonist binding properties of rat pancreatic and cardiac muscarinic receptors  

SciTech Connect (OSTI)

The antagonist binding properties of rat pancreatic and cardiac muscarinic receptors were compared. In both tissues pirenzepine (PZ) had a low affinity for muscarinic receptors labelled by (/sup 3/H)N-methylscopolamine ((/sup 3/)NMS) (K/sub D/ values of 140 and 280nM, respectively, in pancreatic and cardiac homogenates). The binding properties of pancreatic and cardiac receptors were, however, markedly different. This was indicated by different affinities for dicyclomine, (11-(/(2-((diethylamino)-methyl)-1-piperidinyl/acetyl)-5, 11-dihydro-6H-pyrido(2,3-b)(1,4) benzodiazepin-6-on)(AFDX-116), 4-diphenylacetoxy-N-methyl-piperidine methobromide (4-DAMP) and hexahydrosiladifenidol (HHSiD). Pancreatic and cardiac muscarinic receptros also showed different (/sup 3/H)NMS association and dissociation rates. These results support the concept of M2 receptor subtypes have different binding kinetic properties. 20 references, 3 figures, 1 table.

Waelbroeck, M.; Camus, J.; Winand, J.; Christophe, J.

1987-11-09T23:59:59.000Z

406

Increased contraction frequency in rat uterine strips treated in vitro with o,p prime -DDT  

SciTech Connect (OSTI)

Elevated levels of DDT and other organochlorine pesticides have been associated with spontaneous abortion and preterm birth in several species, including humans. Despite the prevalence of organochlorine pesticides in the environment, a mechanistic basis for this association has not been explored. Furthermore, while DDT has been associated with inhibition of calcium ATPases, altered gap junctional communication and electrophysiological changes, all of which could affect the excitation-contraction process characteristic of smooth muscle, direct effects of DDT on uterine smooth muscle have not been reported. This study was initiated to assess the direct effects of o,p{prime}-DDT (an estrogenic isomer present in the technical grade preparation) on pregnant rat uterine tissue.

Juberg, D.R.; Loch-Caruso, R. (Univ. of Michigan, Ann Arbor (United States))

1991-05-01T23:59:59.000Z

407

Laser speckle-imaging of blood microcirculation in the brain cortex of laboratory rats in stress  

SciTech Connect (OSTI)

The results of experimental approbation of the method of laser full-field speckle-imaging for monitoring the changes in blood microcirculation state of the brain cortex of laboratory rats under the conditions of developing stroke and administration of vasodilating and vasoconstrictive agents are presented. The studies aimed at the choice of the optimal conditions of speckle-image formation and recording were performed and the software implementing an adaptive algorithm for processing the data of measurements was created. The transfer of laser radiation to the probed region of the biotissue was implemented by means of a silica-polymer optical fibre. The problems and prospects of speckle-imaging of cerebral microcirculation of blood in laboratory and clinical conditions are discussed.

Vilensky, M A; Semyachkina-Glushkovskaya, Oxana V; Timoshina, P A; Kuznetsova, Jana V; Semyachkin-Glushkovskii, I A; Agafonov, Dmitry N; Tuchin, Valerii V

2012-06-30T23:59:59.000Z

408

Dynamic Multiscale Boundary Conditions for 4D CT Images of Healthy and Emphysematous Rat  

SciTech Connect (OSTI)

Changes in the shape of the lung during breathing determine the movement of airways and alveoli, and thus impact airflow dynamics. Modeling airflow dynamics in health and disease is a key goal for predictive multiscale models of respiration. Past efforts to model changes in lung shape during breathing have measured shape at multiple breath-holds. However, breath-holds do not capture hysteretic differences between inspiration and expiration resulting from the additional energy required for inspiration. Alternatively, imaging dynamically – without breath-holds – allows measurement of hysteretic differences. In this study, we acquire multiple micro-CT images per breath (4DCT) in live rats, and from these images we develop, for the first time, dynamic volume maps. These maps show changes in local volume across the entire lung throughout the breathing cycle and accurately predict the global pressure-volume (PV) hysteresis.

Jacob, Rick E.; Carson, James P.; Thomas, Mathew; Einstein, Daniel R.

2013-06-14T23:59:59.000Z

409

Distribution of phospholipase C isozymes in various rat tissues and cultured cells  

SciTech Connect (OSTI)

Monoclonal antibodies prepared against PLC-I or PLC-II enzyme did not cross-react with the other. Using a pair of antibodies which recognizes 2 different antigenic sites on the same molecule, radioimmunoassays were developed for the quantitation of PLC-I and PLC-II in homogenates of various tissues and cultured cells, prepared by homogenization in a 2 M KCl buffer. The contents of PLC enzymes were measured in 19 rat tissues, in human platelets and in 17 cultured cells. Results indicate that the concentration of PLC-I and PLC-II is very high in brain, PLC-I is localized mainly in brain and partly in seminal vesicles, PLC-II is found in most tissues and cells. PLC-I is highly localized even in brain: 5 different neuroblastoma did not contain PLC-I while 2 glioma and 1 astrocytoma contained significant amounts.

Suh, P.G.; Ryu, S.H.; Choi, W.C.; Lee, K.Y.; Rhee, S.G.

1987-05-01T23:59:59.000Z

410

The effect of iron chloride and glutamate on glutamine synthetase activity in primary cultured rat cortical astrocytes: a model for epileptic induction  

E-Print Network [OSTI]

THE EFFECT OF IRON CHLORIDE AND GLUTAMATE ON GLUTAMINE SYNTHETASE ACTIVITY IN PRIMARY CULTURED RAT CORTICAL ASTROCYTES: A MODEL POR EPILEPTIC INDUCTION A Thesis by JULIE ANN ROBERTS Submitted to the Graduate College of Texas ARM University... in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1986 Major Subject: Veterinary Anatomy THE EFFECT OF IRON CHLORIDE AND GLUTAMATE ON GLUTAMINE SYNTHETASE ACTIVITY IN PRIMARY CULTURED RAT CORTICAL ASTROCYTES: A...

Roberts, Julie Ann

1986-01-01T23:59:59.000Z

411

Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: Possible involvement of angiotensin-converting enzyme-2  

SciTech Connect (OSTI)

Chronic cigarette smoking induces pulmonary arterial hypertension (PAH) by largely unknown mechanisms. Renin-angiotensin system (RAS) is known to function in the development of PAH. Losartan, a specific angiotensin II receptor antagonist, is a well-known antihypertensive drug with a potential role in regulating angiotensin-converting enzyme-2 (ACE2), a recently found regulator of RAS. To determine the effect of losartan on smoke-induced PAH and its possible mechanism, rats were daily exposed to cigarette smoke for 6 months in the absence and in the presence of losartan. Elevated right ventricular systolic pressure (RVSP), thickened wall of pulmonary arteries with apparent medial hypertrophy along with increased angiotensin II (Ang II) and decreased ACE2 levels were observed in smoke-exposed-only rats. Losartan administration ameliorated pulmonary vascular remodeling, inhibited the smoke-induced RVSP and Ang II elevation and partially reversed the ACE2 decrease in rat lungs. In cultured primary pulmonary artery smooth muscle cells (PASMCs) from 3- and 6-month smoke-exposed rats, ACE2 levels were significantly lower than in those from the control rats. Moreover, PASMCs from 6-month exposed rats proliferated more rapidly than those from 3-month exposed or control rats, and cells grew even more rapidly in the presence of DX600, an ACE2 inhibitor. Consistent with the in vivo study, in vitro losartan pretreatment also inhibited cigarette smoke extract (CSE)-induced cell proliferation and ACE2 reduction in rat PASMCs. The results suggest that losartan may be therapeutically useful in the chronic smoking-induced pulmonary vascular remodeling and PAH and ACE2 may be involved as part of its mechanism. Our study might provide insight into the development of new therapeutic interventions for PAH smokers.

Han Suxia; He Guangming; Wang Tao; Chen Lei; Ning Yunye; Luo Feng; An Jin; Yang Ting; Dong Jiajia; Liao Zenglin; Xu Dan [Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 (China); Wen Fuqiang, E-mail: wenfuqiang.scu@gmail.co [Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 (China)

2010-05-15T23:59:59.000Z

412

Stabilization of mitochondrial membrane potential prevents doxorubicin-induced cardiotoxicity in isolated rat heart  

SciTech Connect (OSTI)

The present study was undertaken to examine the effects of doxorubicin on left ventricular function and cellular energy state in intact isolated hearts, and, to test whether inhibition of mitochondrial membrane potential dissipation would prevent doxorubicin-induced mitochondrial and myocardial dysfunction. Myocardial contractile performance and mitochondrial respiration were evaluated by left ventricular tension and its first derivatives and cardiac fiber respirometry, respectively. NADH levels, mitochondrial membrane potential and glucose uptake were monitored non-invasively via epicardial imaging of the left ventricular wall of Langendorff-perfused rat hearts. Heart performance was reduced in a time-dependent manner in isolated rat hearts perfused with Krebs-Henseleit solution containing 1 muM doxorubicin. Compared with controls, doxorubicin induced acute myocardial dysfunction (dF/dt{sub max} of 105 +- 8 mN/s in control hearts vs. 49 +- 7 mN/s in doxorubicin-treated hearts; *p < 0.05). In cardiac fibers prepared from perfused hearts, doxorubicin induced depression of mitochondrial respiration (respiratory control ratio of 4.0 +- 0.2 in control hearts vs. 2.2 +- 0.2 in doxorubicin-treated hearts; *p < 0.05) and cytochrome c oxidase kinetic activity (24 +- 1 muM cytochrome c/min/mg in control hearts vs. 14 +- 3 muM cytochrome c/min/mg in doxorubicin-treated hearts; *p < 0.05). Acute cardiotoxicity induced by doxorubicin was accompanied by NADH redox state, mitochondrial membrane potential, and glucose uptake reduction. Inhibition of mitochondrial permeability transition pore opening by cyclosporine A largely prevented mitochondrial membrane potential dissipation, cardiac energy state and dysfunction. These results suggest that in intact hearts an impairment of mitochondrial metabolism is involved in the development of doxorubicin cardiotoxicity.

Montaigne, David; Marechal, Xavier [Department of Physiology (EA 2689), Faculty of Medicine, University Lille 2, IFR 114 (IMPRT), Lille (France); Baccouch, Riadh [Department of Pharmacy CHRU Lille (France); Modine, Thomas [Department of Cardiovascular Surgery, University Hospital, Lille (France); Preau, Sebastien [Department of Physiology (EA 2689), Faculty of Medicine, University Lille 2, IFR 114 (IMPRT), Lille (France); Zannis, Konstantinos [Department of Cardiovascular Surgery, University Hospital, Lille (France); Marchetti, Philippe [INSERM U 837 Faculty of Medicine, University Lille 2, Lille (France); Lancel, Steve [Department of Physiology (EA 2689), Faculty of Medicine, University Lille 2, IFR 114 (IMPRT), Lille (France); Neviere, Remi, E-mail: rneviere@univ-lille2.f [Department of Physiology (EA 2689), Faculty of Medicine, University Lille 2, IFR 114 (IMPRT), Lille (France)

2010-05-01T23:59:59.000Z

413

Evaluation of the pharmacokinetics and cardiotoxicity of doxorubicin in rat receiving nilotinib  

SciTech Connect (OSTI)

Doxorubicin (DOX) is a potent chemotherapy drug with a narrow therapeutic window. Nilotinib, a small-molecule Bcr-Abl tyrosine kinase inhibitor, was reported to reverse multidrug resistance (MDR) mediated by P-glycoprotein (P-gp) transmembrane transporters. The present study aimed to investigate nilotinib's affection on the steady-state pharmacokinetics, disposition and cardiotoxicity of DOX. A total of 24 male Sprague–Dawley rats were randomized into four groups (6 in each) and received the following regimens: saline, intravenous DOX (5 mg/kg) alone, and DOX co-administrated with either 20 or 40 mg/kg nilotinib. Blood was withdrawn at 12 time points till 72 h after DOX injection and the concentrations of DOX and its metabolite doxorubicinol (DOXol) in serum and cardiac tissue were assayed by LC–MS–MS method. To determine the cardiotoxicity, the following parameters were investigated: creatine kinase, lactate dehydrogenase, malondialdehyde, and superoxide dismutase. Histopathological examination of heart section was carried out to evaluate the extent of cardiotoxicity after treatments. The results showed that pretreatment of 40 mg/kg nilotinib increased the AUC{sub 0–t} and C{sub max} of DOX and DOXol. However, their accumulation in cardiac tissue was significantly decreased when compared with the group that received DOX alone. In addition, biochemical and histopathological results showed that 40 mg/kg nilotinib reduced the cardiotoxicity induced by DOX administration. In conclusion, co-administration of nilotinib increased serum exposure, but significantly decreased the accumulation of DOX in cardiac tissue. Consistent with in vitro profile, oral dose of 40 mg/kg nilotinib significantly decreased the cardiotoxicity of DOX in rat by enhancing P-gp activity in the heart.

Zhou, Zhi-yong [Department of Pharmacy, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, 200233 Shanghai (China); School of Pharmacy, Shanghai Jiao Tong University, 200240 Shanghai (China); Wan, Li-li; Yang, Quan-jun; Han, Yong-long; Li, Yan; Yu, Qi [Department of Pharmacy, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, 200233 Shanghai (China); Guo, Cheng, E-mail: guochengphd@yahoo.com.cn [Department of Pharmacy, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, 200233 Shanghai (China); School of Pharmacy, Shanghai Jiao Tong University, 200240 Shanghai (China); Li, Xiao, E-mail: lixiao3326@yahoo.com.cn [Department of Hematology, Affiliated Sixth people's Hospital, Shanghai Jiao Tong University, 200233 Shanghai (China)

2013-10-01T23:59:59.000Z

414

Age-dependent pharmacokinetic and pharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos  

SciTech Connect (OSTI)

Juvenile rats are more susceptible than adults to the acute toxicity of organophosphorus insecticides like chlorpyrifos (CPF). Age- and dose-dependent differences in metabolism may be responsible. Of importance is CYP450 activation and detoxification of CPF to CPF-oxon and 3,5,6-trichloro-2-pyridinol (TCP), as well as B-esterase (cholinesterase; ChE) and A-esterase (PON-1) detoxification of CPF-oxon to TCP. The pharmacokinetics of CPF, TCP, and the extent of blood (plasma/RBC), and brain ChE inhibition in rats were determined on postnatal days (PND) -5, -12, and -17 following oral gavage administration of 1 and 10 mg CPF/kg of body weight. For all neonatal ages the blood TCP exceeded the CPF concentration, and within each age group there was no evidence of non-linear kinetics over the dose range evaluated. Younger animals demonstrated a greater sensitivity to ChE inhibition as evident by the dose- and age-dependent inhibition of plasma, RBC, and brain ChE. Of particular importance was the observation that even in rats as young as PND-5, the CYP450 metabolic capacity was adequate to metabolize CPF to both TCP and CPF-oxon based on the detection of TCP in blood and extensive ChE inhibition (biomarker of CPF-oxon) at all ages. In addition, the increase in the blood TCP concentration ({approx}3-fold) in PND-17 rats relative to the response in the younger animals, and the higher blood concentrations of CPF in neonatal rats (1.7 to 7.5-fold) relative to adults was consistent with an increase in CYP450 metabolic capacity with age. This is the first reported study that evaluated both the pharmacokinetics of the parent pesticide, the major metabolite and the extent of ChE inhibition dynamics in the same animals as a function of neonatal age. The results suggest that in the neonatal rat, CPF was rapidly absorbed and metabolized, and the extent of metabolism was age-dependent.

Timchalk, Chuck; Poet, Torka S.; Kousba, Ahmed A.

2006-03-01T23:59:59.000Z

415

Timing and magnitude of Miocene eustasy derived from the mixed siliciclastic-carbonate stratigraphic record of the northeastern Australian margin  

E-Print Network [OSTI]

(deep-sea Miocene isotope events Mi1b, Mbi-3, Mi2, Mi2a, Mi3a, Mi3, Mi4, and Mi5, respectively), which

Leckie, Mark

416

Protective Effects of Repetitive Injections of Radiographic Contrast Media on the Subsequent Tolerance to Ischemia in the Isolated Rat Heart  

SciTech Connect (OSTI)

Purpose: Despite detailed knowledge of the effects of X-ray contrast media on cardiac function, no studies have examined the effect of contrast media injections on the subsequent tolerance to ischemia in the heart.Methods: Isolated perfused rat hearts were exposed to repetitive injections of iohexol, iodixanol, or ioxaglate before 30 min of global ischemia and 120 min of reperfusion. These groups were compared with control (no pretreatment) and ischemic preconditioning known to reduce infarct size. Physiologic variables and infarct size were measured. Results: Pretreatment with iodixanol reduced infarct size significantly compared with control and thus afforded protection against ischemia. Injections with iohexol and ioxaglate reduced infarct size, although not significantly, compared with control.Conclusion: Pretreatment of the isolated rat heart with commonly used contrast media enhances the cardiac tolerance to subsequent ischemia. The mechanism behind this protective effect could not be determined, but could involve stretching of the heart and/or generation of nitric oxide.

Falck, Geir; Bruvold, Morten [Department of Physiology and Biomedical Engineering, Norwegian University of Science and Technology, Medisinsk Teknisk Senter, N-7489 Trondheim (Norway); Schjott, Jan [Experimental Cardiology Unit, RELIS VEST, Haukeland Hospital, N-5021 Bergen (Norway); Jynge, Per [Department of Physiology and Biomedical Engineering, Norwegian University of Science and Technology, Medisinsk Teknisk Senter, N-7489 Trondheim (Norway)

2000-11-15T23:59:59.000Z

417

A Novel Method for the Evaluation of Mechanical Properties of Cancellous Bone in the Rat Distal Femur  

E-Print Network [OSTI]

Walton Lucas, B.S., Lipscomb University Co-Chairs of Advisory Committee: Dr. Harry Hogan Dr. Susan Bloomfield The mechanical properties of the cancellous bone in the laboratory rat animal model... the cortical shell for 50 slices in a region starting ~0.5 mm below the most proximal portion of the growth plate for each animal. Images were binarized (threshold of 100 on a 0-255 scale) and the following parameters were assessed for the three- dimensional...

Lucas, Matthew W.

2010-01-14T23:59:59.000Z

418

Atrazine-induced reproductive tract alterations after transplacental and/or lactational exposure in male Long-Evans rats  

SciTech Connect (OSTI)

Studies showed that early postnatal exposure to the herbicide atrazine (ATR) delayed preputial separation (PPS) and increased incidence of prostate inflammation in adult Wistar rats. A cross-fostering paradigm was used in this study to determine if gestational exposure to ATR would also result in altered puberty and reproductive tissue effects in the male rat. Timed-pregnant Long-Evans (LE) rats were dosed by gavage on gestational days (GD) 15-19 with 100 mg ATR/kg body weight (BW) or 1% methylcellulose (controls, C). On postnatal day (PND)1, half litters were cross-fostered, creating 4 treatment groups; C-C, ATR-C, C-ATR, and ATR-ATR (transplacental-milk as source, respectively). On PND4, male offspring in the ATR-ATR group weighed significantly less than the C-C males. ATR-ATR male pups had significantly delayed preputial separation (PPS). BWs at PPS for C-ATR and ATR-ATR males were reduced by 6% and 9%, respectively, from that of C-C. On PND120, lateral prostate weights of males in the ATR-ATR group were significantly increased over C-C. Histological examination of lateral and ventral prostates identified an increased distribution of inflammation in the lateral prostates of C-ATR males. By PND220, lateral prostate weights were significantly increased for ATR-C and ATR-ATR, but there were no significant changes in inflammation in either the lateral or ventral prostate. These results suggest that in LE rats, gestational ATR exposure delays PPS when male offspring suckle an ATR dam, but leads to increased lateral prostate weight via transplacental exposure alone. Inflammation present at PND120 does not increase in severity with time.

Rayner, Jennifer L. [Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States); Reproductive Toxicology Division, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 (United States); Enoch, Rolondo R. [Reproductive Toxicology Division, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 (United States); Wolf, Douglas C. [Environmental Carcinogenesis Division, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 (United States); Fenton, Suzanne E. [Reproductive Toxicology Division, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 (United States)]. E-mail: fenton.suzanne@epa.gov

2007-02-01T23:59:59.000Z

419

Metabolic Rate Constants for Hydroquinone in F344 Rat and Human Liver Isolated Hepatocytes: Application to a PBPK model.  

SciTech Connect (OSTI)

Hydroquinone (HQ) is an important industrial chemical that also occurs naturally in foods and in the leaves and bark of a number of plant species. Exposure of laboratory animals to HQ may result in a species-, sex-, and strain-specific nephrotoxicity. The sensitivity of male F344 vs. female F344 and Sprague-Dawley rats or B6C3F1 mice appears to be related to differences in the rates of formation and further metabolism of key nephrotoxic metabolites. Metabolic rate constants for the conversion of HQ through several metabolic steps to the mono-glutathione conjugate and subsequent detoxification via mercapturic acid were measured in suspension cultures of hepatocytes isolated from male F344 rats and humans. An in vitro mathematic kinetic model was used to analyze each metabolic step by simultaneously fitting the disappearance of each substrate and the appearance of subsequent metabolites. An iterative, nested approach was used whereby downstream metabolites were considered first and the model was constrained by the requirement that rate constants determined during analysis of individual metabolic steps must also satisfy the complete, integrated metabolism scheme, including competitive pathways. The results from this study indicated that the overall capacity for metabolism of HQ and its mono-glutathione conjugate is greater in hepatocytes from humans than those isolated from rats, suggesting a greater capacity for detoxification of the glutathione conjugates. Metabolic rate constants were applied to an existing physiologically based pharmacokinetic model and the model was used to predict total glutathione metabolites produced in the liver. The results showed that body burdens of these metabolites will be much higher in rats than humans.

Poet, Torka S.; Wu, Hong; English, J C.; Corley, Rick A.

2004-11-15T23:59:59.000Z

420

Biochemical and behavioral effects of phospholipase A/sub 2/ and morphine microinjections in the periaqueductal gray of the rat  

SciTech Connect (OSTI)

In order to characterize the in vivo action of phospholipase A/sub 2/ (PLA/sub 2/) on opiate receptors and opiate-induced behaviors, the effects of injections of PLA/sub 2/ into the periaqueductal gray region (PAG) of the rat were assessed on free fatty acid (FFA) release, opiate-binding levels, and morphine-induced behaviors. Rats received bilateral PAG injections of 2 ..mu..g of PLA/sub 2/ while anesthetized. One hour later, regions around the cannulae tracts in PLA/sub 2/-treated rats contained over 2.5 times more FFA than saline-injected controls, and /sup 3/H-dihydromorphine binding was reduced on average more than 70%. In another series of experiments, conscious rats were given 2 ..mu..g of PLA/sub 2/ prior to 10 ..mu..g of morphine through cannulae chronically implanted into the PAG. PLA/sub 2/ did not significantly attenuate morphine-induced analgesia as measured by the tail-flick test to radiant heat, but did prevent the explosive motor behavior observed following morphine injections alone. PLA/sub 2/ by itself did not induce analgesia, but did cause explosive motor behavior 2 hr after the injections. Neither lysophosphatidylcholine nor trypsin resulted in motor seizures following PAG injections. It was concluded that the behavioral effects of PLA/sub 2/ result from the unique properties of the enzyme, rather than generalized membrane damage, and that the opioid sites and mechanisms that mediate analgesia are different from those associated with explosive motor behavior. 36 references, 2 figures, 2 tables.

Reichman, M.; Abood, L.G.; Costanzo, M.

1985-02-11T23:59:59.000Z

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421

Dietary long-chain, but not medium-chain, triglycerides impair exercise performance and uncouple cardiac mitochondria in rats  

E-Print Network [OSTI]

RESEARCH Open Access Dietary long-chain, but not medium-chain, triglycerides impair exercise performance and uncouple cardiac mitochondria in rats Andrew J Murray*, Nicholas S Knight, Sarah E Little, Lowri E Cochlin, Mary Clements and Kieran Clarke... mitochondria were mea- sured using a Clark-type oxygen electrode (Strathkelvin Instruments Ltd, Glasgow, UK), as described previously [18]. The chambers were treated identically throughout the experiment, except that one contained 1 ?mol GDP added...

Murray, Andrew J; Knight, Nicholas S; Little, Sarah E; Cochlin, Lowri E; Clements, Mary; Clarke, Kieran

2011-08-01T23:59:59.000Z

422

Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts  

SciTech Connect (OSTI)

The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that is activated by extracellular calcium (Ca {sub o} {sup 2+}). Rat-1 fibroblasts have been shown to proliferate and increase ERK activity in response to elevation of [Ca{sup 2+}] {sub o}, and these responses are dependent on functional CaR expression. In this report, we examined the role of cross-talk between the CaR and the epidermal growth factor receptor (EGFR) in mediating these responses in Rat-1 cells. This report shows that AG1478, a specific inhibitor of the EGFR kinase, significantly inhibits the increase in proliferation induced by elevated Ca {sub o} {sup 2+}. Furthermore, we show that AG1478 acts downstream or separately from G protein subunit activation of phospholipase C. AG1478 significantly inhibits Ca {sub o} {sup 2+}-stimulated ERK phosphorylation and in vitro kinase activity. A similar inhibition of ERK phosphorylation was observed in response to the inhibitor AG494. In addition, treatment with inhibitors of metalloproteases involved in shedding of membrane anchored EGF family ligands substantially inhibited the increase in ERK activation in response to elevated Ca {sub o} {sup 2+}. This is consistent with the known expression of TGF{alpha} by Rat-1 cells. These results indicate that EGFR transactivation is an important component of the CaR-mediated response to increased Ca {sub o} {sup 2+} in Rat-1 fibroblasts and most likely involves CaR-mediated induction of regulated proteolysis and ligand shedding.

Tomlins, Scott A. [University of Michigan Medical School, Ann Arbor, MI 48109 (United States); Bolllinger, Nikki [Biological Sciences Division, Battelle for the US DOE, PO Box 999, 790 Sixth Street, Richland, WA 99352 (United States); Creim, Jeffrey [Biological Sciences Division, Battelle for the US DOE, PO Box 999, 790 Sixth Street, Richland, WA 99352 (United States); Rodland, Karin D. [Biological Sciences Division, Battelle for the US DOE, PO Box 999, 790 Sixth Street, Richland, WA 99352 (United States)]. E-mail: Karin.rodland@pnl.gov

2005-08-15T23:59:59.000Z

423

Enhanced neocortical neural sprouting, synaptogenesis, and behavioral recovery with D-amphetamine therapy after neocortical infarction in rats  

E-Print Network [OSTI]

Background and Purpose—D-Amphetamine administration increases behavioral recovery after various cortical lesions including cortical ablations, contusions, and focal ischemia in animals and after stroke in humans. The purpose of the present study was to test the enhanced behavioral recovery and increased expression of proteins involved in neurite growth and synaptogenesis in D-amphetamine–treated rats compared with vehicle-treated controls after a focal neocortical infarct. Methods—Unilateral neocortical ischemia was induced in male spontaneously hypertensive Wistar rats (n?8 per time point per group) by permanently occluding the distal middle cerebral artery and ipsilateral common carotid artery in 2 groups of rats: D-amphetamine treated (2 mg/kg IP injections) and vehicle treated (saline IP injections). To determine the spatial and temporal distribution of neurite growth and/or synaptogenesis, growth-associated protein (GAP-43), a protein expressed on axonal growth cones, and synaptophysin, a calcium-binding protein found on synaptic vesicles, were examined by immunohistochemical techniques, and both density and distribution of reaction product were measured. Since the resulting infarction included a portion of the forelimb neocortex, behavioral assessments of forelimb function using the foot-fault test of Hernandez and Schallert were performed on the same rats used for immunohistochemical studies during the period of drug action and 24 hours later. A Morris water maze and other indices of behavioral assays were also measured similarly. Recovery times were 3, 7, 14, 30, and 60 days postoperatively. Results—Both GAP-43 and synaptophysin proteins demonstrated statistically significant increases in density and

R. Paul Stroemer; Phd Thomas; A. Kent; Md Claire; E. Hulsebosch

1998-01-01T23:59:59.000Z

424

The effects of exogenously administered pineal gland extract and melatonin on some reproductive aspects in the albino rat  

E-Print Network [OSTI]

THE EFFECTS OF EXOGENOUSLY ADMINISTERED PINEAL GLAND EXTRACT AND MELATONIN ON SOME REPRODUCTIVE ASPECTS IN THE ALBINO RAT A Thesis by MILTON J. HERNANDEZ-PEREZ Submitted to the Graduate College of the Texas A&M University in partial... by MILTON J. HERNANDEZ-PEREZ Approved as to style and content by: (Chairman o'f Committee) (Head of Department) (Member) (Member) (Member) May 1967 ACKNOWLEDGEHENTS I sincerely thank Dr. George M. Krise, Dr. Sidney 0. Brown, and Dr. H. R. Crookshank...

Hernandez-Perez, Milton John

1967-01-01T23:59:59.000Z

425

Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: An FTIR microspectroscopic imaging study  

SciTech Connect (OSTI)

Amifostine is the only approved radioprotective agent by FDA for reducing the damaging effects of radiation on healthy tissues. In this study, the protective effect of amifostine against the damaging effects of ionizing radiation on the white matter (WM) and grey matter (GM) regions of the rat brain were investigated at molecular level. Sprague-Dawley rats, which were administered amifostine or not, were whole-body irradiated at a single dose of 800 cGy, decapitated after 24 h and the brain tissues of these rats were analyzed using Fourier transform infrared microspectroscopy (FTIRM). The results revealed that the total lipid content and CH{sub 2} groups of lipids decreased significantly and the carbonyl esters, olefinic=CH and CH{sub 3} groups of lipids increased significantly in the WM and GM after exposure to ionizing radiation, which could be interpreted as a result of lipid peroxidation. These changes were more prominent in the WM of the brain. The administration of amifostine before ionizing radiation inhibited the radiation-induced lipid peroxidation in the brain. In addition, this study indicated that FTIRM provides a novel approach for monitoring ionizing radiation induced-lipid peroxidation and obtaining different molecular ratio images can be used as biomarkers to detect lipid peroxidation in biological systems.

Cakmak G.; Miller L.; Zorlu, F.; Severcan, F.

2012-03-03T23:59:59.000Z

426

Chronic graft-versus-host disease in the rat radiation chimera. III. Immunology and immunopathology in rapidly induced models  

SciTech Connect (OSTI)

Although chronic graft-versus-host disease (GVHD) frequently develops in the long-term rat radiation chimera, we present three additional models in which a histologically similar disease is rapidly induced. These include adoptive transfer of spleen and bone marrow from rats with spontaneous chronic GVHD into lethally irradiated rats of the primary host strain; sublethal irradiation of stable chimeras followed by a booster transplant; and transfer of spleen cells of chimeras recovering from acute GVHD into second-party (primary recipient strain) or third-party hosts. Some immunopathologic and immune abnormalities associated with spontaneous chronic GVHD were not observed in one or more of the induced models. Thus, IgM deposition in the skin, antinuclear antibodies, and vasculitis appear to be paraphenomena. On the other hand, lymphoid hypocellularity of the thymic medulla, immaturity of splenic follicles, and nonspecific suppressor cells were consistently present in the long term chimeras, and in all models. These abnormalities therefore may be pathogenetically important, or closely related to the development of chronic GVHD.

Beschorner, W.E.; Tutschka, P.J.; Santos, G.W.

1983-03-01T23:59:59.000Z

427

Comparison of 60-Hz electric fields and incandescent light as aversive stimuli controlling the behavior of rats  

SciTech Connect (OSTI)

Rats were exposed to two procedures which enabled them to press a lever to turn off a 90 or 100 kV/m 60-Hz electric field or, later in the study, illumination from an incandescent lamp. Under one procedure, a response turned off the stimulus for a fixed duration, after which the stimulus was turned on again. A response during the off-period restarted the fixed duration. None of the rats turned the field off reliably. Next, under an alternative procedure, pressing one lever turned the field off; pressing the other lever turned it back on; responding under those conditions differed little from that seen at 0 kV/m. Under both procedures, when illumination from an incandescent lamp served as the stimulus, each rat did turn the stimulus off, and performances varied with stimulus intensity. The results show that a 100 kV/m 60-Hz electric field is not sufficient to function as an aversive stimulus under two procedures where illumination from a lamp does function as an aversive stimulus.

Stern, S.; Laties, V.G.

1989-01-01T23:59:59.000Z

428

Cysteamine, zinc, and thiols modify detectability of rat pituitary prolactin: a comparison with effects on bovine prolactin suggests differences in hormone storage  

SciTech Connect (OSTI)

Little is known about the structure of prolactin (PRL) within secretory granules. Evidence from our previous studies in bovine tissue preparations suggests that control of secretion may reside, in part, in the conversion of storage hormone to releasable PRL. The conversion can be monitored by measuring changes in immunodetectability since the oligomeric, storage form is poorly recognized by antisera raised against monomeric PRL. Since many investigators use rats to study the secretory process and changes in detectability of rat pituitary PRL occur during lactation (depletion-transformation), we undertook the present immunodetectability studies to gain insight into the storage structure of rat (r) PRL. Cysteamine and zinc inhibited tissue PRL immunoassayability in male rat pituitary homogenates and also in partially purified secretory granules as they had inhibited bovine (b) PRL; however, zinc inhibited the rodent hormone less potently than the bovine. In vitro incubation of rat tissue samples without additions resulted in increases in rPRL detectability of up to 84% after 180 minutes; such incubation of bovine samples had no significant effect. A striking additional difference between the species was that exposure to reduced glutathione (GSH), cysteine, homocysteine, mercaptoethanol, and dithiothreitol inhibited rPRL by up to 44%. This compared to thiol stimulation of bPRL by as much as 450%. The inhibitory GSH effect on rPRL was abolished when 0.5% sodium dodecyl sulfate (SDS) was included; in contrast, the stimulatory GSH effect on bPRL did not change with added SDS. SDS alone had no effect on rat homogenate PRL, and only increased rat granule rPRL by 23% compared to its ability to increase bPRL assayability by 44%.

Jacobs, L.S.; Lorenson, M.Y.

1986-03-01T23:59:59.000Z

429

Acute effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate, on cardiovascular parameters in anaesthetized, artificially ventilated rats  

SciTech Connect (OSTI)

The organophosphorus compound sarin irreversibly inhibits acetylcholinesterase. We examined the acute cardiovascular effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate (BIMP), in anaesthetized, artificially ventilated rats. Intravenous administration of BIMP (0.8 mg/kg; the LD50 value) induced a long-lasting increase in blood pressure and tended to increase heart rate. In rats pretreated with the non-selective muscarinic-receptor antagonist atropine, BIMP significantly increased both heart rate and blood pressure. In atropine-treated rats, hexamethonium (antagonist of ganglionic nicotinic receptors) greatly attenuated the BIMP-induced increase in blood pressure without changing the BIMP-induced increase in heart rate. In rats treated with atropine plus hexamethonium, intravenous phentolamine (non-selective ?-adrenergic receptor antagonist) plus propranolol (non-selective ?-adrenergic receptor antagonist) completely blocked the BIMP-induced increases in blood pressure and heart rate. In atropine-treated rats, the reversible acetylcholinesterase inhibitor neostigmine (1 mg/kg) induced a transient increase in blood pressure, but had no effect on heart rate. These results suggest that in anaesthetized rats, BIMP induces powerful stimulation of sympathetic as well as parasympathetic nerves and thereby modulates heart rate and blood pressure. They may also indicate that an action independent of acetylcholinesterase inhibition contributes to the acute cardiovascular responses induced by BIMP. - Highlights: • A sarin-like agent BIMP markedly increased blood pressure in anaesthetized rats. • Muscarinic receptor blockade enhanced the BIMP-induced increase in blood pressure. • Ganglionic nicotinic receptor blockade attenuated the BIMP-induced response. • Blockade of ?- as well as ?-receptors attenuated the BIMP-induced response.

Watanabe, Yoshimasa [Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya (Japan); Itoh, Takeo, E-mail: titoh@med.nagoya-cu.ac.jp [Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya (Japan); Shiraishi, Hiroaki [Department of Forensic Medicine, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima (Japan); Maeno, Yoshitaka [Department of Forensic Medical Science, Graduate School of Medical Sciences, Nagoya City University, Nagoya (Japan); Arima, Yosuke; Torikoshi, Aiko; Namera, Akira [Department of Forensic Medicine, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima (Japan); Makita, Ryosuke [Department of Nursing, Faculty of Health Sciences, Hiroshima Cosmopolitan University, Hiroshima (Japan); Yoshizumi, Masao [Department of Cardiovascular Physiology and Medicine, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima (Japan); Nagao, Masataka [Department of Forensic Medicine, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima (Japan)

2013-10-01T23:59:59.000Z

430

Activation of the canonical nuclear factor-?B pathway is involved in isoflurane-induced hippocampal interleukin-1? elevation and the resultant cognitive deficits in aged rats  

SciTech Connect (OSTI)

Highlights: •Isoflurane induces hippocampal IL-1? elevation and cognitive deficits in aged rats. •Isoflurane transiently activates the canonical NF-?B pathway in aged rat hippocampus. •NF-?B inhibitor mitigates isoflurane-induced IL-1? elevation and cognitive deficits. •We report a linkage between NF-?B signaling, IL-1? expression, and cognitive changes. -- Abstract: Although much recent evidence has demonstrated that neuroinflammation contributes to volatile anesthetic-induced cognitive deficits, there are few existing mechanistic explanations for this inflammatory process. This study was conducted to investigate the effects of the volatile anesthetic isoflurane on canonical nuclear factor (NF)-?B signaling, and to explore its association with hippocampal interleukin (IL)-1? levels and anesthetic-related cognitive changes in aged rats. After a 4-h exposure to 1.5% isoflurane in 20-month-old rats, increases in I?B kinase and I?B phosphorylation, as well as a reduction in the NF-?B inhibitory protein (I?B?), were observed in the hippocampi of isoflurane-exposed rats compared with control rats. These events were accompanied by an increase in NF-?B p65 nuclear translocation at 6 h after isoflurane exposure and hippocampal IL-1? elevation from 1 to 6 h after isoflurane exposure. Nevertheless, no significant neuroglia activation was observed. Pharmacological inhibition of NF-?B activation by pyrrolidine dithiocarbamate markedly suppressed the IL-1? increase and NF-?B signaling, and also mitigated the severity of cognitive deficits in the Morris water maze task. Overall, our results demonstrate that isoflurane-induced cognitive deficits may stem from upregulation of hippocampal IL-1?, partially via activation of the canonical NF-?B pathway, in aged rats.

Li, Zheng-Qian; Rong, Xiao-Ying; Liu, Ya-Jie; Ni, Cheng [Department of Anesthesiology, Peking University Third Hospital, Beijing 100191 (China)] [Department of Anesthesiology, Peking University Third Hospital, Beijing 100191 (China); Tian, Xiao-Sheng [Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Ministry of Education and Ministry of Public Health, Peking University Health Science Center, Beijing 100191 (China)] [Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Ministry of Education and Ministry of Public Health, Peking University Health Science Center, Beijing 100191 (China); Mo, Na [Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021 (China)] [Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021 (China); Chui, De-Hua, E-mail: dchui@bjmu.edu.cn [Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Ministry of Education and Ministry of Public Health, Peking University Health Science Center, Beijing 100191 (China)] [Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Ministry of Education and Ministry of Public Health, Peking University Health Science Center, Beijing 100191 (China); Guo, Xiang-Yang, E-mail: puthmzk@163.com [Department of Anesthesiology, Peking University Third Hospital, Beijing 100191 (China)] [Department of Anesthesiology, Peking University Third Hospital, Beijing 100191 (China)

2013-09-06T23:59:59.000Z

431

TCDD dysregulation of 13 AHR-target genes in rat liver  

SciTech Connect (OSTI)

Despite several decades of research, the complete mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other xenobiotic agonists of the aryl hydrocarbon receptor (AHR) cause toxicity remains unclear. While it has been shown that the AHR is required for all major manifestations of toxicity, the specific downstream changes involved in the development of toxic phenotypes remain unknown. Here we examine a panel of 13 genes that are AHR-regulated in many species and tissues. We profiled their hepatic mRNA abundances in two rat strains with very different sensitivities to TCDD: the TCDD-sensitive Long–Evans (Turku/AB; L–E) and the TCDD-resistant Han/Wistar (Kuopio; H/W). We evaluated doses ranging from 0 to 3000 ?g/kg at 19 h after TCDD exposure and time points ranging from 1.5 to 384 h after exposure to 100 ?g/kg TCDD. Twelve of 13 genes responded to TCDD in at least one strain, and seven of these showed statistically significant inter-strain differences in the time course analysis (Aldh3a1, Cyp1a2, Cyp1b1, Cyp2a1, Fmo1, Nfe2l2 and Nqo1). Cyp2s1 did not respond to TCDD in either rat strain. Five genes exhibited biphasic responses to TCDD insult (Ahrr, Aldh3a1, Cyp1b1, Nfe2l2 and Nqo1), suggesting a secondary event, such as association with additional transcriptional modulators. Of the 12 genes that responded to TCDD during the dose–response analysis, none had an ED{sub 50} equivalent to that of Cyp1a1, the most sensitive gene in this study, while nine genes responded to doses at least 10–100 fold higher, in at least one strain (Ahrr (L–E), Aldh3a1 (both), Cyp1a2 (both), Cyp1b1 (both), Cyp2a1 (L–E), Inmt (both), Nfe2l2 (L–E), Nqo1 (L–E) and Tiparp (both)). These data shed new light on the association of the AHR target genes with TCDD toxicity, and in particular the seven genes exhibiting strain-specific differences represent strong candidate mediators of Type-II toxicities. - Highlights: • NanoString measured hepatic mRNA molecules following TCDD treatment. • TCDD-sensitive Long–Evans and TCDD-resistant Han/Wistar rats were compared. • Time courses and dose responses were analyzed for AHR-core gene changes. • 7 genes displayed inter-strain mRNA differences at times after TCDD exposure. • 2 of the AHR-core genes had significant inter-strain differences in their TCDD ED{sub 50}.

Watson, John D., E-mail: john.watson@oicr.on.ca [Ontario Institute for Cancer Research, Department of Informatics and Bio-computing Program, Toronto (Canada); Prokopec, Stephenie D., E-mail: stephenie.prokopec@oicr.on.ca [Ontario Institute for Cancer Research, Department of Informatics and Bio-computing Program, Toronto (Canada); Smith, Ashley B., E-mail: ashleyblaines@gmail.com [Ontario Institute for Cancer Research, Department of Informatics and Bio-computing Program, Toronto (Canada); Okey, Allan B., E-mail: allan.okey@utoronto.ca [Department of Pharmacology and Toxicology, University of Toronto, Toronto (Canada); Pohjanvirta, Raimo, E-mail: raimo.pohjanvirta@helsinki.fi [Laboratory of Toxicology, National Institute for Health and Welfare, Kuopio (Finland); Department of Food Hygiene and Environmental Health, University of Helsinki, Helsinki (Finland); Boutros, Paul C., E-mail: paul.boutros@oicr.on.ca [Ontario Institute for Cancer Research, Department of Informatics and Bio-computing Program, Toronto (Canada); Department of Pharmacology and Toxicology, University of Toronto, Toronto (Canada); Department of Medical Biophysics, University of Toronto, Toronto (Canada)

2014-02-01T23:59:59.000Z

432

Effects of cysteamine on pituitary, MTTW15 tumor, and serum prolactin levels measured by rat lymphoma cell bioassay and radioimmunoassay  

SciTech Connect (OSTI)

Cysteamine (CSH), a sulfhydryl compound, reduces both serum and anterior pituitary (AP) PRL measured by RIA. We have used the Nb2 lymphoma cell bioassay (BIO) for PRL to evaluate possible CSH-related changes in PRL levels in sera and tissues of male and MtTW15 mammosomatotropic tumor-bearing female rats. Experimental animals received a single sc injection of CSH (300 mg/kg), and samples were collected 0.5-24 h later. Since CSH and serum from CSH rats were toxic in BIO, samples were dialyzed before assay. All samples were evaluated for PRL and GH by RIA as well. A significant decrease (P less than 0.05) in BIO serum PRL was evident in male rats 0.5 h after CSH; levels remained low for 24 h. Serum PRL by RIA was significantly depressed at 4 h but not at 0.5 h or 24 h. PRL in AP extracts was decreased (60-90%) at all times by BIO and RIA. Significant decreases of BIO- and RIA-detectable PRL were recorded in serum and tissues (AP and tumors) at 4 h in tumor rats. Sequentially bled (0.5-4 h) CSH-treated tumor-bearing rats showed 50% and 80% reductions in serum PRL at 1 and 4 h by both BIO and RIA. CSH had no effect on GH levels in sera and tissues of any animal studied at any time interval. Our results substantiate earlier reports on CSH-induced decreases in RIA-detectable PRL. They show that such changes cannot be attributed to assay effects alone, as significant decreases in circulating and stored PRL (both AP and tumor) were evident by BIO. Results with tissue extracts were the most dramatic. They suggest an action of CSH or a metabolic intermediate with stored PRL which reduces both extractable PRL and hormone release. Such an effect of CSH on PRL extraction has been suggested by others. Whatever the mechanism, it appears to be relatively specific, since GH cells were not affected.

Parsons, J.A.; Peterson, E.K.; Hartfel, M.A.

1984-05-01T23:59:59.000Z

433

Proximal renal tubular injury in rats sub-chronically exposed to low fluoride concentrations  

SciTech Connect (OSTI)

Fluoride is usually found in groundwater at a very wide range of concentration between 0.5 and 25 ppm. At present, few studies have assessed the renal effects of fluoride at environmentally relevant concentrations. Furthermore, most of these studies have used insensitive and nonspecific biomarkers of kidney injury. The aim of this study was to use early and sensitive biomarkers to evaluate kidney injury after fluoride exposure to environmentally relevant concentrations. Recently weaned male Wistar rats were exposed to low (15 ppm) and high (50 ppm) fluoride concentrations in drinking water for a period of 40 days. At the end of the exposure period, kidney injury biomarkers were measured in urine and renal mRNA expression levels were assessed by real time RT-PCR. Our results showed that the urinary kidney injury molecule (Kim-1), clusterin (Clu), osteopontin (OPN) and heat shock protein 72 excretion rate significantly increased in the group exposed to the high fluoride concentration. Accordingly, fluoride exposure increased renal Kim-1, Clu and OPN mRNA expression levels. Moreover, there was a significant dose-dependent increase in urinary ?-2-microglobulin and cystatin-C excretion rate. Additionally, a tendency towards a dose dependent increase of tubular damage in the histopathological light microscopy findings confirmed the preferential impact of fluoride on the tubular structure. All of these changes occurred at early stages in which, the renal function was not altered. In conclusion using early and sensitive biomarkers of kidney injury, we were able to found proximal tubular alterations in rats sub-chronically exposed to fluoride. - Highlights: • Exposure to low concentrations of fluoride induced proximal tubular injury • Increase in urinary Kim-1, Clu, OPN and Hsp72 in 50 ppm fluoride-exposed group • Increase in urinary B2M and CysC in 15 and 50 ppm fluoride-exposed groups • Fluoride exposure increased renal Kim, Clu and OPN mRNA expression levels. • Fluoride increased kidney injury biomarkers at stages where eGFR was unaltered.

Cárdenas-González, Mariana C.; Del Razo, Luz M. [Departmento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México, D. F., México (Mexico); Barrera-Chimal, Jonatan [Unidad de Fisiología Molecular, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D. F., México (Mexico); Jacobo-Estrada, Tania [Departmento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México, D. F., México (Mexico); López-Bayghen, Esther [Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México, D. F., México (Mexico); and others

2013-11-01T23:59:59.000Z

434

Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats  

SciTech Connect (OSTI)

Chlorpyrifos (CPF) is one of the most studied and widely used broad spectrum organophosphorus (OP) insecticides. The neurotoxicity of CPF results from inhibition of cholinesterase (ChE) by its metabolite, chlorpyrifos-oxon (CPF-oxon), which subsequently leads to cholinergic hyperstimulation. The routine consumption of alcoholic beverages and tobacco products will modify a number of metabolic and physiological processes which may impact the metabolism and pharmacokinetics of other xenobiotics including pesticides. The objective of this study was to evaluate the influence of repeated ethanol and nicotine co-exposure on in vivo CPF pharmacokinetics and pharmacodynamics. The major CPF metabolite, 3,5,6-trichloro-2-pyridinol (TCPy) in blood and urine along with changes in plasma and brain AChE activities were measured in male Sprague-Dawley (S-D) rats. Animals were repeatedly treated with either saline or ethanol (1 g/kg/day, po) and nicotine (1 mg/kg/day, sc) in addition to CPF (1 or 5 mg/kg/day, po) for 7 days. Rats were sacrificed at times from 1 to 24 hr post-last dosing of CPF. There were apparent differences in blood TCPy pharmacokinetics following ethanol and nicotine pretreatments in both CPF dose groups, which showed higher TCPy peak concentrations and increased blood TCPy AUC in ethanol and nicotine groups over CPF-only (~1.8- and 3.8-fold at 1 and 5 mg CPF doses, respectively). Brain acetylcholinesterase (AChE) activities from both ethanol and nicotine-treated groups showed substantially less inhibition following repeated 5 mg CPF/kg dosing compared to CPF-only controls (96 ± 13 and 66 ± 7% of naïve at 4 hr post-last CPF dosing, respectively). Inhibition of brain AChE activities was minimal in both 1 mg CPF/kg/day dosing groups, but a similar trend indicating less inhibition following ethanol/nicotine pretreatment was apparent. No differences were observed in plasma ChE activities due to the combined alcohol and nicotine treatments. In vitro, CPF metabolism was not affected by repeated treatments with ethanol or both ethanol and nicotine. When compared with a previous study of nicotine and CPF exposure, there were no apparent additional exacerbating effects due to ethanol co-exposure.

Lee, Soo Kwang; Poet, Torka S.; Smith, Jordan N.; Busby-Hjerpe, Andrea L.; Timchalk, Charles

2010-03-30T23:59:59.000Z

435

Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry  

SciTech Connect (OSTI)

Imaging mass spectrometry offers simultaneous detection of drugs, drug metabolites and endogenous substances in a single experiment. This is important when evaluating effects of a drug on a complex organ system such as the brain, where there is a need to understand how regional drug distribution impacts function. Nicotine is an addictive drug and its action in the brain is of high interest. Here we use nanospray desorption electrospray ionization, nano-DESI, imaging to discover the localization of nicotine in rat brain tissue after in vivo administration of nicotine. Nano-DESI is a new ambient technique that enables spatially-resolved analysis of tissue samples without special sample pretreatment. We demonstrate high sensitivity of nano-DESI imaging that enables detection of only 0.7 fmole nicotine per pixel in the complex brain matrix. Furthermore, by adding deuterated nicotine to the solvent, we examined how matrix effects, ion suppression, and normalization affect the observed nicotine distribution. Finally, we provide preliminary results suggesting that nicotine localizes to the hippocampal substructure called dentate gyrus.

Lanekoff, Ingela T.; Thomas, Mathew; Carson, James P.; Smith, Jordan N.; Timchalk, Charles; Laskin, Julia

2013-01-15T23:59:59.000Z

436

Deterioration in brain and heart functions following a single sub-lethal (0.8 LCt{sub 50}) inhalation exposure of rats to sarin vapor:  

SciTech Connect (OSTI)

The main injuries among victims of the terrorist act in the Tokyo subway resulted from sub-lethal inhalation and whole body exposure to sarin vapor. In order to study the long term effects of such exposure and to simulate these conditions, freely moving rats were exposed to sarin vapor (27.2 {+-} 1.7 {mu}g/l) for 10 min. About 50% of the rats showed no overt symptoms and the rest had mild to moderate clinical symptoms that subsided within 4 h following exposure. A reduction of weight was noted during the first 3 days with full recovery on the 4th day. Rat's heart was challenged with epinephrine 1 and 6 months post exposure. A significant reduction in the threshold for epinephrine-induced arrhythmia (EPIA) was noted in rats exposed to sarin. A time dependent increase in the kD and Bmax values of muscarinic auto receptors (M2) was recorded in the rat's cortex and striatum. No changes were recorded in the rats' brain trans locator protein (TSPO) levels, concomitant with no observed changes in the animals' performance in A Morris water maze test. A significant increase in open field activity was noted 6 months following exposure to sarin vapor as well as a significant decrease in prostaglandin E{sub 2} (PGE{sub 2}) production in the brain. It is speculated that down regulation of the M2 auto receptor function, caused hyper reactivity of the cholinergic system which leads to the changes described above. The continuous reduction in M2 auto-receptor system through an unknown mechanism may be the cause for long lasting decline in sarin-exposed casualties' health.

Allon, N., E-mail: nahuma@iibr.gov.il; Chapman, S.; Egoz, I.; Rabinovitz, I.; Kapon, J.; Weissman, B.A.; Yacov, G.; Bloch-Shilderman, E.; Grauer, E.

2011-05-15T23:59:59.000Z

437

Prevention and Treatment of Functional and Structural Radiation Injury in the Rat Heart by Pentoxifylline and Alpha-Tocopherol  

SciTech Connect (OSTI)

Purpose: Radiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of pentoxifylline (PTX) and {alpha}-tocopherol on cardiac injury in a rat model of RIHD. Methods and Materials: Male Sprague-Dawley rats received fractionated local heart irradiation with a daily dose of 9 Gy for 5 days and were observed for 6 months after irradiation. Rats were treated with a combination of PTX, 100 mg/kg/day, and {alpha}-tocopherol (20 IU/kg/day) and received these compounds either from 1 week before until 6 months after irradiation or starting 3 months after irradiation, a time point at which histopathologic changes become apparent in our model of RIHD. Results: Radiation-induced increases in left ventricular diastolic pressure (in mm Hg: 35 {+-} 6 after sham-irradiation, 82 {+-} 11 after irradiation) were significantly reduced by PTX and {alpha}-tocopherol (early treatment: 48 {+-} 7; late treatment: 53 {+-} 6). PTX and {alpha}-tocopherol significantly reduced deposition of collagen types I (radiation only: 3.5 {+-} 0.2 {mu}m{sup 2} per 100 {mu}m{sup 2}; early treatment: 2.7 {+-} 0.8; late treatment: 2.2 {+-} 0.2) and III (radiation only: 13.9 {+-} 0.8; early treatment: 11.0 {+-} 1.2; late treatment: 10.6 {+-} 0.8). On the other hand, radiation-induced alterations in heart/body weight ratios, myocardial degeneration, left ventricular mast cell densities, and most echocardiographic parameters were not significantly altered by PTX and {alpha}-tocopherol. Conclusions: Treatment with PTX and {alpha}-tocopherol may have beneficial effects on radiation-induced myocardial fibrosis and left ventricular function, both when started before irradiation and when started later during the process of RIHD.

Boerma, Marjan [Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR (United States)], E-mail: mboerma@uams.edu; Roberto, Kerrey A. [Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR (United States); Hauer-Jensen, Martin [Departments of Surgery and Pathology, University of Arkansas for Medical Sciences, and Surgical Service, Central Arkansas Veterans Healthcare System, Little Rock, AR (United States)

2008-09-01T23:59:59.000Z

438

Effect of in vivo heart irradiation on the development of antioxidant defenses and cardiac functions in the rat  

SciTech Connect (OSTI)

During radiotherapy of thoracic tumors, the heart is often included in the primary treatment volume, and chronic impairment of myocardial function occurs. The cellular biomolecules are altered directly by radiation or damaged indirectly by free radical production. The purpose of this investigation was to evaluate the biochemical and functional response of the rat heart to a single high dose of radiation. The effect of 20 Gy local X irradiation was determined in the heart of Wistar rats under general anesthesia. Mechanical performances were measured in vitro using an isolated perfused working heart model, and cardiac antioxidant defenses were also evaluated. Hearts were studied at 1 and 4 months after irradiation. This single dose of radiation induced a marked drop in the mechanical activity of the rat heart: aortic output was significantly reduced (18% less than control values) at 1 month postirradiation and remained depressed for the rest of the experimental period (21% less than control 4 months after treatment). This suggests the development of myocardial failure after irradiation. The decline of functional parameters was associated with changes in antioxidant defenses. The decrease in cardiac levels of vitamin E (-30%) was associated with an increase in the levels of Mn-SOD and glustathione peroxidase (+45.5% and +32%, respectively, at 4 months postirradiation). However, cardiac vitamin C and catalase levels remained constant. Since these antioxidant defenses were activated relatively long after irradiation, it is suggested that this was probable due to the production of free radical species associated with the development of inflammation. 49 refs., 8 figs., 1 tab.

Benderitter, M.; Assem, M.; Maupoil, V. [Facultes de Medecine et de Pharmacie, Dijon (France)] [and others

1995-10-01T23:59:59.000Z

439

Interactive toxicity of inorganic mercury and trichloroethylene in rat and human proximal tubules: Effects on apoptosis, necrosis, and glutathione status  

SciTech Connect (OSTI)

Simultaneous or prior exposure to one chemical may alter the concurrent or subsequent response to another chemical, often in unexpected ways. This is particularly true when the two chemicals share common mechanisms of action. The present study uses the paradigm of prior exposure to study the interactive toxicity between inorganic mercury (Hg{sup 2+}) and trichloroethylene (TRI) or its metabolite S-(1,2-dichlorovinyl)-L-cysteine (DCVC) in rat and human proximal tubule. Pretreatment of rats with a subtoxic dose of Hg{sup 2+} increased expression of glutathione S-transferase-{alpha}1 (GST{alpha}1) but decreased expression of GST{alpha}2, increased activities of several GSH-dependent enzymes, and increased GSH conjugation of TRI. Primary cultures of rat proximal tubular (rPT) cells exhibited both necrosis and apoptosis after incubation with Hg{sup 2+}. Pretreatment of human proximal tubular (hPT) cells with Hg{sup 2+} caused little or no changes in GST expression or activities of GSH-dependent enzymes, decreased apoptosis induced by TRI or DCVC, but increased necrosis induced by DCVC. In contrast, pretreatment of hPT cells with TRI or DCVC protected from Hg{sup 2+} by decreasing necrosis and increasing apoptosis. Thus, whereas pretreatment of hPT cells with Hg{sup 2+} exacerbated cellular injury due to TRI or DCVC by shifting the response from apoptosis to necrosis, pretreatment of hPT cells with either TRI or DCVC protected from Hg{sup 2+}-induced cytotoxicity by shifting the response from necrosis to apoptosis. These results demonstrate that by altering processes related to GSH status, susceptibilities of rPT and hPT cells to acute injury from Hg{sup 2+}, TRI, or DCVC are markedly altered by prior exposures.

Lash, Lawrence H. [Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201 (United States)]. E-mail: l.h.lash@wayne.edu; Putt, David A. [Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201 (United States); Hueni, Sarah E. [Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201 (United States); Payton, Scott G. [Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201 (United States); Zwickl, Joshua [Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201 (United States)

2007-06-15T23:59:59.000Z

440

Pulmonary endothelium response after brain and cutaneous exposure to ND-Yag and CO/sub 2/ laser in rats  

SciTech Connect (OSTI)

Angiotensin converting enzyme (ACE) and Plasminogen Activator (PLA), two enzymes regulating blood pressure and coagulation and secreted by lung endothelial cells are affected by indirect injuries (cutaneous burn, hemorrhagic shock and bleomycin administration). Reported here are the results of lung metabolic response to CO/sub 2/, and ND-Yag laser and heat application. Lung ACE, PLA and protein, and serum ACE and protein were measured. Through left parietal craniectomy two groups, each of 10 anesthetized male rats (200 g) were exposed one to ND-Yag and the other to CO/sub 2/ laser application (both set at 35 watts/1/10 second 1.5 mm spot), on the brain surface. A third group had only craniectomy and a fourth only anesthesia. Sacrifice was 24 hours later. No significant differences in serum and lung ACE, PLA and protein were observed in the last 2 groups of rats and in those ones treated with CO/sub 2/ laser. ND-Yag laser caused a significant increase (p < 0.05) of lung PLA. Similar groups of rats were exposed to cutaneous application of CO/sub 2/ laser, and to contact heat of 100/sup 0/C and 270/sup 0/C for 10'' (a total of 40 animals including controls). CO/sub 2/ laser caused a moderate increase (p < 0.05) of lung protein and ACE with no PLA changes. Cutaneous burn caused a marked decline (p < 0.01) of lung ACE and protein and an increase of lung PLA (p < 0.05). Both CO/sub 2/ laser and burn decreased serum ACE (p < 0.05). Brain exposure to ND-Yag caused marked metabolic changes in lung endothelium. Cutaneous application of CO/sub 2/ laser had a modest influence on the studied enzymes, while the effect of skin burn on lung endothelium was somewhat similar to that of ND-Yag laser.

Brizio-Molteni, L.; Quigley, M.; Cerullo, L.; Solliday, N.; Molteni, A.

1986-03-05T23:59:59.000Z

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441

The bulking effect of dietary fiber in the rat large intestine: an in vivo study of cellulose, guar, pectin, wheat bran and oat bran  

E-Print Network [OSTI]

THE BULKING EFFECT OF DIETARY FIBER IN THE RAT LARGE INTESTINE: AN IN VIVO STUDY OF CELLULOSE, GUAR, PECTIN, WHEAT BRAN AND OAT BRAN A Thesis by JEANNE MARIE GAZZANIGA Submitted to the Graduate College of Texas A&M University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1985 Major Subject: Nutrition THE BULKING EFFECT OF DIETARY FIBER IN THE RAT LARGE INTESTINE: AN IN VIVO STUDY OF CELLULOSE, GUAR, PECTIN, WHEAT BRAN AND OAT BRAN A Thesis...

Gazzaniga, Jeanne Marie

1985-01-01T23:59:59.000Z

442

Comparison of benzo(a)pyrene metabolism and mutation induction in CHO cells using rat liver homogenate (S9) or Syrian hamster embryonic cell-mediated activation systems  

SciTech Connect (OSTI)

Mutagenesis in CHO cells has been studied by the addition of an ezymatically active liver homogenate (S9) fraction. However, the metabolism of procarcinogens, such as benzo(a)pyrene (B(a)P), by rat liver homogenate differs from that in intact cellular activation systems. Consequently, B(a)P-induced mutation frequencies in mammalian cells may vary when different activation systems are used. This study attempts to compare B(a)P metabolism and conjugation in rat liver homogenate (S9 preparation) and in Syrian hamster embryonic (SHE) cells. Furthermore, a CHO mutation assay incorporating either of the activation systems is being used to measure the mutation induction frequency.

Chen, D.J.; Okinaka, R.T.; Strniste, G.F.

1981-01-01T23:59:59.000Z

443

Comparative study of genotoxicity and tissue distribution of nano and micron sized iron oxide in rats after acute oral treatment  

SciTech Connect (OSTI)

Though nanomaterials (NMs) are being utilized worldwide, increasing use of NMs have raised concerns over their safety to human health and environment. Iron oxide (Fe{sub 2}O{sub 3}) NMs have important applications. The aim of this study was to assess the genotoxicity of Fe{sub 2}O{sub 3}-30 nm and Fe{sub 2}O{sub 3}-bulk in female Wistar rats. Fe{sub 2}O{sub 3}-30 nm was characterized by using transmission electron microscopy, dynamic light scattering, laser Doppler velocimetry and surface area analysis. The rats were treated orally with the single doses of 500, 1000, 2000 mg/kg bw of Fe{sub 2}O{sub 3}-30 nm and Fe{sub 2}O{sub 3} –bulk. The genotoxicity was evaluated at 6, 24, 48 and 72 h by the comet assay in leucocytes, 48 and 72 h by micronucleus test (MNT) in peripheral blood cells, 18 and 24 h by chromosomal aberration (CA) assay and 24 and 48 h by MNT in bone marrow cells. The biodistribution of iron (Fe) was carried out at 6, 24, 48 and 72 h after treatment in liver, spleen, kidney, heart, brain, bone marrow, urine and feces by using atomic absorption spectrophotometry. The % tail DNA, frequencies of micronuclei and CAs were statistically insignificant (p > 0.05) at all doses. These results suggest that Fe{sub 2}O{sub 3}-30 nm and Fe{sub 2}O{sub 3}-bulk was not genotoxic at the doses tested. Bioavailability of Fe was size and dose dependent in all the tissues from the groups exposed to Fe{sub 2}O{sub 3}-30 nm. Fe{sub 2}O{sub 3} NMs were able to enter in the organs and the rats are biocompatible with much higher concentration of Fe. However, the accumulated Fe did not cause significant genotoxicity. This study provides additional knowledge about the toxicology of Fe{sub 2}O{sub 3} NMs. -- Highlights: ? Fe{sub 2}O{sub 3}-30 nm and Fe{sub 2}O{sub 3}-bulk were orally administered to rats with single doses. ? The nano and bulk Fe{sub 2}O{sub 3} showed insignificant results with MNT, comet and CA assays. ? The bulk was excreted via feces whereas the NMs were found both in urine and feces. ? The NMs mainly accumulated in the liver, spleen, kidney, heart and bone marrow. ? However the accumulated Fe did not cause significant genotoxicological effects.

Singh, Shailendra Pratap; Rahman, M.F.; Murty, U.S.N.; Mahboob, M.; Grover, Paramjit, E-mail: paramgrover@gmail.com

2013-01-01T23:59:59.000Z

444

Fermentation of pectin and cellulose to short chain fatty acids: a comparative study with humans, baboons, pigs, and rats  

E-Print Network [OSTI]

digestibility to the human results. SCFA were measured using gas chromatography. The pH was measured before and after the fermentations. The percent fiber remaining after fermentation was assayed colorimetrically. The greatest interspecies differences were...%I@ W, W, '. '" yW~, t . . . M~~~)~ '1 r FERMENTATION OF PECTIN AND CELLULOSE TO SHORT CHAIN FATTY ACIDS: A COMPARATIVE STUDY WITH HUMANS, BABOONS, PIGS, AND RATS A Thesis by LEONILDE NONITA VILLALBA IL W I Z IJ Z 4 Z 4 2 5 V Z I...

Villalba, Leonilde Nonita

1989-01-01T23:59:59.000Z

445

On-Off Intermittency in Time Series of Spontaneous Paroxysmal Activity in Rats with Genetic Absence Epilepsy  

E-Print Network [OSTI]

Dynamic behavior of complex neuronal ensembles is a topic comprising a streamline of current researches worldwide. In this article we study the behavior manifested by epileptic brain, in the case of spontaneous non-convulsive paroxysmal activity. For this purpose we analyzed archived long-term recording of paroxysmal activity in animals genetically susceptible to absence epilepsy, namely WAG/Rij rats. We first report that the brain activity alternated between normal states and epilepsy paroxysms is the on-off intermittency phenomenon which has been observed and studied earlier in the different nonlinear systems.

A. E. Hramov; A. A. Koronovskii; I. S. Midzyanovskaya; E. Sitnikova; C. M. van Rijn

2006-12-22T23:59:59.000Z

446

Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels in rat hippocampus: Influence on cholinergic toxicity  

SciTech Connect (OSTI)

Parathion (PS) and chlorpyrifos (CPF) are organophosphorus insecticides (OPs) that elicit acute toxicity by inhibiting acetylcholinesterase (AChE). Endocannabinoids (eCBs, N-arachidonoylethanolamine, AEA; 2-arachidonoylglycerol, 2AG) can modulate neurotransmission by inhibiting neurotransmitter release. We proposed that differential inhibition of eCB-degrading enzymes (fatty acid amide hydrolase, FAAH, and monoacylglycerol lipase, MAGL) by PS and CPF leads to differences in extracellular eCB levels and toxicity. Microdialysis cannulae were implanted into hippocampus of adult male rats followed by treatment with vehicle (peanut oil, 2 ml/kg, sc), PS (27 mg/kg) or CPF (280 mg/kg) 6–7 days later. Signs of toxicity, AChE, FAAH and MAGL inhibition, and extracellular levels of AEA and 2AG were measured 2 and 4 days later. Signs were noted in PS-treated rats but not in controls or CPF-treated rats. Cholinesterase inhibition was extensive in hippocampus with PS (89–90%) and CPF (78–83%) exposure. FAAH activity was also markedly reduced (88–91%) by both OPs at both time-points. MAGL was inhibited by both OPs but to a lesser degree (35–50%). Increases in extracellular AEA levels were noted after either PS (about 2-fold) or CPF (about 3-fold) while lesser treatment-related 2-AG changes were noted. The cannabinoid CB1 receptor antagonist/inverse agonist AM251 (3 mg/kg, ip) had no influence on functional signs after CPF but markedly decreased toxicity in PS-treated rats. The results suggest that extracellular eCBs levels can be markedly elevated by both PS and CPF. CB1-mediated signaling appears to play a role in the acute toxicity of PS but the role of eCBs in CPF toxicity remains unclear. - Highlights: • Chlorpyrifos and parathion both extensively inhibited hippocampal cholinesterase. • Functional signs were only noted with parathion. • Chlorpyrifos and parathion increased hippocampal extracellular anandamide levels. • 2-Arachidonoylglycerol levels were lesser affected. • The CB1 antagonist AM251 had no effect on chlorpyrifos but reduced parathion toxicity.

Liu, Jing [Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK (United States); Parsons, Loren [Committee on Neurobiology of Affective Disorders, The Scripps Research Institute, La Jolla, CA (United States); Pope, Carey, E-mail: carey.pope@okstate.edu [Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK (United States)

2013-11-01T23:59:59.000Z

447

The effect of temperature and oxygen level on the production of testosterone, androstenedione and progesterone by rat testis in vitro  

E-Print Network [OSTI]

THE EFFECT OF TEMPERATURE AND OXYGEN LEVEL ON THE PRODUCTION OF TESTOSTERONE, ANDROSTFNEDIONE AND PROGESTERONE BY RAT TESTIS IN VITRO A Thesis by PETER ANTHONY DUDLEY Submitted to the Graduate College of the Texas A%M University in partial... IN VITRO A Thesis by PETER ANTHONY DUDLEY Approved as to style and content by: (C irman of Committee) (Head of Department) &, 'Mcmbe r ) ' M c'm b e r ) AC KN OW LEDG MENTS The author i'eels extremely fortunate to have had as the chair- man...

Dudley, Peter Anthony

1969-01-01T23:59:59.000Z

448

The oncogenic action of ionizing radiation on rat skin. Final progress report, May 1, 1990--April 30, 1992  

SciTech Connect (OSTI)

The multistage theory of carcinogenesis specifies that cells progress to cancer through a series of discrete, irreversible genetic alterations, but data on radiation-induced cancer incidence in rat skin suggests that an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to an electron beam (LET=0.34 keV/{mu}), a neon ion beam (LET=45) or an argon ion beam (LET=125). The rats were observed for tumors at least 78 weeks with squamous and basal cell carcinomas observed. The total cancer yield was fitted by the quadratic equation, and the equation parameters were estimated by linear regression for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces stable, carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable linked event pathway at high LET; either pathway may advance the cell by 1 stage. The proliferative response of rat epidermis following exposure to ionizing radiation was quantified by injection of {sup 14}C-thymidine. The return of these cells to S-phase a second time was detected by a second label ({sup 3}H). When the labeled cells were in G1-phase, the dorsal skin was irradiated with X-rays. All labeling indices were determined. The {sup 14}C labeling index was constant and unaffected by the radiation. The proportion of all cells entering S-phase averaged 3.5% at 18 hr and increased after 44, 52 and 75 hr to average levels of 11.8%, 5. 3%, and 6.6% at 0, 10 and 25 Gy respectively. The proportion of S-phase cells labeled with {sup 14}C increased after 42 hr and remained relatively constant thereafter.

Burns, F.J.; Garte, S.J.

1992-12-31T23:59:59.000Z

449

Effects of naloxone and immobilization stress upon the pulsatile release of luteinizing hormone in the ovariectomized rat  

E-Print Network [OSTI]

hormone se- cretion has been described as having two modes of release; a basal or tonic mode found in both males and females and a preovulatory LH surge found in adult females at the time of ovulation (Kalra and Kalra, 1983; Reeves, 1980; McCann, 1977... believed to act through use of cANP (Ganong, 1981c). The effect of DA upon LHRH or LH release is the sub- ject of much study. Kalra and Kalra (1983) stated that only a minor role of DA upon LH release in the male rat exists and in the ovariectomized...

Crawford, Kimberly Ann

1984-01-01T23:59:59.000Z

450

Effect of dietary magnesium and calcium on blood lipids and minerals in tissues in rats fed a high fat diet  

E-Print Network [OSTI]

EFFECT OF DIETARY MAGNESIUM AND CALCIUM ON BLOOD LIPIDS AND MINERALS ZN TISSUES IN BATS FED A HIGH FAT DIET A Thesis by JEAN CONBOY-DONNS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE May 1991 Major Subject: Nutrition EFFECT OF DIETARY MAGNESIUM AND CALCIUM ON BLOOD LIPZDS AND MZNERALS ZN TISSUES IN RATS FED A BIGS FAT DIET A Thesis by JEAN CONBOY-DOWNS Approved as to style...

Conboy-Downs, Jean

2012-06-07T23:59:59.000Z

451

Calcium-sensing receptor activation contributed to apoptosis stimulates TRPC6 channel in rat neonatal ventricular myocytes  

SciTech Connect (OSTI)

Capacitative calcium entry (CCE) refers to the influx of calcium through plasma membrane channels activated on depletion of endoplasmic sarcoplasmic/reticulum (ER/SR) Ca{sup 2+} stores, which is performed mainly by the transient receptor potential (TRP) channels. TRP channels are expressed in cardiomyocytes. Calcium-sensing receptor (CaR) is also expressed in rat cardiac tissue and plays an important role in mediating cardiomyocyte apoptosis. However, there are no data regarding the link between CaR and TRP channels in rat heart. In this study, in rat neonatal myocytes, by Ca{sup 2+} imaging, we found that the depletion of ER/SR Ca{sup 2+} stores by thapsigargin (TG) elicited a transient rise in cytoplasmic Ca{sup 2+} ([Ca{sup 2+}]{sub i}), followed by sustained increase depending on extracellular Ca{sup 2+}. But, TRP channels inhibitor (SKF96365), not L-type channels or the Na{sup +}/Ca{sup 2+} exchanger inhibitors, inhibited [Ca{sup 2+}]{sub i} relatively high. Then, we found that the stimulation of CaR with its activator gadolinium chloride (GdCl{sub 3}) or by an increased extracellular Ca{sup 2+}([Ca{sup 2+}]{sub o}) increased the concentration of intracelluar Ca{sup 2+}, whereas, the sustained elevation of [Ca{sup 2+}]{sub i} was reduced in the presence of SKF96365. Similarly, the duration of [Ca{sup 2+}]{sub i} increase was also shortened in the absence of extracellular Ca{sup 2+}. Western blot analysis showed that GdCl{sub 3} increased the expression of TRPC6, which was reversed by SKF96365. Additionally, SKF96365 reduced cardiomyocyte apoptosis induced by GdCl{sub 3}. Our results suggested that CCE exhibited in rat neonatal myocytes and CaR activation induced Ca{sup 2+}-permeable cationic channels TRPCs to gate the CCE, for which TRPC6 was one of the most likely candidates. TRPC6 channel was functionally coupled with CaR to enhance the cardiomyocyte apoptosis.

Sun, Yi-hua [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Li, Yong-quan [Harbin Medical University, Harbin 150086 (China)] [Harbin Medical University, Harbin 150086 (China); Feng, Shan-li [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Li, Bao-xin; Pan, Zhen-wei [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China)] [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Xu, Chang-qing [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China)] [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Li, Ting-ting [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Yang, Bao-feng, E-mail: syh200415@yahoo.com.cn [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China)] [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China)

2010-04-16T23:59:59.000Z

452

Effects of phenylethanolamine N-methyltransferase inhibitors on uptake and release of norepinephrine and dopamine from rat brain  

SciTech Connect (OSTI)

Inhibitors of phenylethanolamine N-methyltransferase (PNMT) and amphetamine were evaluated for their effects on the uptake of (TH)-norepinephrine (TH-NE) and the release of endogenous NE and dopamine (DA) from chopped rat brain tissues. Unlike amphetamine, all of PNMT inhibitors tested produced only slight inhibition of (TH)-NE uptake into chopped cerebral cortex. 2,3-Dichloro-alpha-methylbenzylamine (DCMB) and 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF64139), but not 2-cyclooctyl-2-hydroxyethylamine (CONH) and 1-aminomethylcycloundecanol (CUNH) produced slight release of endogenous NE and DA from chopped hypothalami, but their effects were less pronounced than those produced by amphetamine.

Liang, N.Y.; Hower, J.A.; Borchardt, R.T.

1985-09-01T23:59:59.000Z

453

Effect of graded hypoxia on retention of technetium-99m-nitroheterocycle in perfused rat heart  

SciTech Connect (OSTI)

The purpose of this investigation was to determine the effects of graded hypoxia on the retention of a {sup 99m}Tc-labeled nitroimidazole. Rat hearts were perfused retrogradely with Krebs-Henseleit buffer at 37{degrees}C and paced at 5 Hz. After a 20-min stabilization period, coronary flow was maintained at 8 ml/min/g wet wt and the hearts were perfused with media equilibrated with gas mixtures containing 5% CO{sub 2} and various levels of O{sub 2}, from 544 to 29 Torr. Technetium-99m-O(PnAO-1-(2-nitroimidazole)), BMS-181321, was infused for 20 min into a side port of the aortic cannula. Perfusion continued for an additional 40 min to allow for compound clearance. Each decrease of perfusate PO{sub 2} brought about an increase in the retention of BMS-181321, resulting in a good correlation between its retention and perfusate PO{sub 2} (r=0.97). Myocardial oxygen consumption was independent of oxygen delivery when the perfusate oxygen pressure was greater than 350 Torr. Below this value, oxygen consumption declined markedly as influent PO{sub 2}. A good correlation was obtained between retention of the nitroheterocycle and the cytosolic lactate/pyruvate ratio (r=0.98). When glucose was omitted from the perfusate (PO{sub 2}=27 Torr), retention of the nitroheterocycle was increased by about 25% as compared to hearts perfused in the presence of this substrate. These results indicate that myocardial retention of BMS-181321 is coupled to the level of tissue oxygenation and that hypoxic retention may be affected by substrate input. 24 refs., 3 figs., 1 tab.

Rumsey, W.L.; Patel, B.; Linder, K.E. [Bristol-Myers Squibb Pharmaceutical Research Inst., Princeton, NJ (United States)

1995-04-01T23:59:59.000Z

454

The Impact of Heart Irradiation on Dose-Volume Effects in the Rat Lung  

SciTech Connect (OSTI)

Purpose: To test the hypothesis that heart irradiation increases the risk of a symptomatic radiation-induced loss of lung function (SRILF) and that this can be well-described as a modulation of the functional reserve of the lung. Methods and Materials: Rats were irradiated with 150-MeV protons. Dose-response curves were obtained for a significant increase in breathing frequency after irradiation of 100%, 75%, 50%, or 25% of the total lung volume, either including or excluding the heart from the irradiation field. A significant increase in the mean respiratory rate after 6-12 weeks compared with 0-4 weeks was defined as SRILF, based on biweekly measurements of the respiratory rate. The critical volume (CV) model was used to describe the risk of SRILF. Fits were done using a maximum likelihood method. Consistency between model and data was tested using a previously developed goodness-of-fit test. Results: The CV model could be fitted consistently to the data for lung irradiation only. However, this fitted model failed to predict the data that also included heart irradiation. Even refitting the model to all data resulted in a significant difference between model and data. These results imply that, although the CV model describes the risk of SRILF when the heart is spared, the model needs to be modified to account for the impact of dose to the heart on the risk of SRILF. Finally, a modified CV model is described that is consistent to all data. Conclusions: The detrimental effect of dose to the heart on the incidence of SRILF can be described by a dose dependent decrease in functional reserve of the lung.

Luijk, Peter van [Department of Radiation Oncology, University Medical Center, Groningen (Netherlands)], E-mail: p.van.luijk@rt.umcg.nl; Faber, Hette [Department of Radiation Oncology, University Medical Center, Groningen (Netherlands); Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Meertens, Harm [Department of Radiation Oncology, University Medical Center, Groningen (Netherlands); Schippers, Jacobus M. [Accelerator Department, Paul Scherrer Institut, Villigen, Switerland (Switzerland); Langendijk, Johannes A. [Department of Radiation Oncology, University Medical Center, Groningen (Netherlands); Brandenburg, Sytze [Kernfysisch Versneller Instituut, University of Groningen, Groningen (Netherlands); Kampinga, Harm H. [Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Coppes, Robert P. Ph.D. [Department of Radiation Oncology, University Medical Center, Groningen (Netherlands); Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)

2007-10-01T23:59:59.000Z

455

Maternal exposure to cadmium during gestation perturbs the vascular system of the adult rat offspring  

SciTech Connect (OSTI)

Several cardiovascular diseases (CVD) observed in adulthood have been associated with environmental influences during fetal growth. Here, we show that maternal exposure to cadmium, a ubiquitously distributed heavy metal and main component of cigarette smoke is able to induce cardiovascular morpho-functional changes in the offspring at adult age. Heart morphology and vascular reactivity were evaluated in the adult offspring of rats exposed to 30 ppm of cadmium during pregnancy. Echocardiographic examination shows altered heart morphology characterized by a concentric left ventricular hypertrophy. Also, we observed a reduced endothelium-dependent reactivity in isolated aortic rings of adult offspring, while endothelium-independent reactivity remained unaltered. These effects were associated with an increase of hem-oxygenase 1 (HO-1) expression in the aortas of adult offspring. The expression of HO-1 was higher in females than males, a finding likely related to the sex-dependent expression of the vascular cell adhesion molecule 1 (VCAM-1), which was lower in the adult female. All these long-term consequences were observed along with normal birth weights and absence of detectable levels of cadmium in fetal and adult tissues of the offspring. In placental tissues however, cadmium levels were detected and correlated with increased NF-{kappa}B expression - a transcription factor sensitive to inflammation and oxidative stress - suggesting a placentary mechanism that affect genes related to the development of the cardiovascular system. Our results provide, for the first time, direct experimental evidence supporting that exposure to cadmium during pregnancy reprograms cardiovascular development of the offspring which in turn may conduce to a long term increased risk of CVD.

Ronco, Ana Maria, E-mail: amronco@inta.cl [Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology (INTA), University of Chile, Casilla 138-11, Santiago (Chile); Montenegro, Marcela; Castillo, Paula; Urrutia, Manuel [Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology (INTA), University of Chile, Casilla 138-11, Santiago (Chile); Saez, Daniel [Faculty of Veterinary Medicine, University of Chile, Casilla 138-11, Santiago (Chile); Hirsch, Sandra [Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology (INTA), University of Chile, Casilla 138-11, Santiago (Chile); Zepeda, Ramiro [Faculty of Medicine, University of Chile, Casilla 138-11, Santiago (Chile); Llanos, Miguel N. [Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology (INTA), University of Chile, Casilla 138-11, Santiago (Chile)

2011-03-01T23:59:59.000Z

456

Uranyl nitrate-exposed rat alveolar macrophages cell death: Influence of superoxide anion and TNF ? mediators  

SciTech Connect (OSTI)

Uranium compounds are widely used in the nuclear fuel cycle, military and many other diverse industrial processes. Health risks associated with uranium exposure include nephrotoxicity, cancer, respiratory, and immune disorders. Macrophages present in body tissues are the main cell type involved in the internalization of uranium particles. To better understand the pathological effects associated with depleted uranium (DU) inhalation, we examined the metabolic activity, phagocytosis, genotoxicity and inflammation on DU-exposed rat alveolar macrophages (12.5–200 ?M). Stability and dissolution of DU could differ depending on the dissolvent and in turn alter its biological action. We dissolved DU in sodium bicarbonate (NaHCO{sub 3} 100 mM) and in what we consider a more physiological vehicle resembling human internal media: sodium chloride (NaCl 0.9%). We demonstrate that uranyl nitrate in NaCl solubilizes, enters the cell, and elicits its cytotoxic effect similarly to when it is diluted in NaHCO{sub 3}. We show that irrespective of the dissolvent employed, uranyl nitrate impairs cell metabolism, and at low doses induces both phagocytosis and generation of superoxide anion (O{sub 2}{sup ?}). At high doses it provokes the secretion of TNF? and through all the range of doses tested, apoptosis. We herein suggest that at DU low doses O{sub 2}{sup ?} may act as the principal mediator of DNA damage while at higher doses the signaling pathway mediated by O{sub 2}{sup ?} may be blocked, prevailing damage to DNA by the TNF? route. The study of macrophage functions after uranyl nitrate treatment could provide insights into the pathophysiology of uranium?related diseases. -- Highlights: ? Uranyl nitrate effect on cultured macrophages is linked to the doses and independent of its solubility. ? At low doses uranyl nitrate induces generation of superoxide anion. ? At high doses uranyl nitrate provokes secretion of TNF?. ? Uranyl nitrate induces apoptosis through all the range of doses tested.

Orona, N.S. [School of Science and Technology, National University of General Martín, Avda Gral Paz 5445 (1650) San Martín, Buenos Aires (Argentina)] [School of Science and Technology, National University of General Martín, Avda Gral Paz 5445 (1650) San Martín, Buenos Aires (Argentina); Tasat, D.R., E-mail: deborah.tasat@unsam.edu.ar [School of Science and Technology, National University of General Martín, Avda Gral Paz 5445 (1650) San Martín, Buenos Aires (Argentina); School of Dentistry, University of Buenos Aires, M. T. de Alvear 2142 (1122), Buenos Aires (Argentina)

2012-06-15T23:59:59.000Z

457

Anti-inflammatory and anti-oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats  

SciTech Connect (OSTI)

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) driven through altered immune responses with production of proinflammatory cytokines. Many therapies are used, but side effects and loss of response limit long-term effectiveness. New therapeutic strategies are thus needed for patients who don't respond to current treatments. Recently, there is suggested involvement of the proinflammatory hormone angiotensin II in inflammatory bowel disease. The aim of this study was to investigate the possible role of olmesartan medoxomil (OLM-M), an angiotensin II receptor blocker in ameliorating ulcerative colitis. Colitis was induced in male Wistar rats by administration of 5% dextran sodium sulphate (DSS) in drinking water for 5 days. OLM-M (1, 3 and 10 mg/kg) was administered orally during 21 days prior to the induction of colitis, and for 5 days after. Sulfasalazine (500 mg/kg) was used as reference drug. All animals were tested for changes in colon length, disease activity index (DAI) and microscopic damage. Colon tissue concentration/activity of tumor necrosis alpha (TNF-?), myeloperoxidase (MPO), prostaglandin E2 (PGE2), reduced glutathione (GSH) and malondialdehyde (MDA) were assessed. Results showed that the OLM-M dose-dependently ameliorated the colonic histopathological and biochemical injuries, an effect that is comparable or even better than that of the standard sulfasalazine. These results suggest that olmesartan medoxomil may be effective in the treatment of UC through its anti-inflammatory and antioxidant effects. - Highlights: • Olmesartan medoximil reduced dextran sodium sulphate- induced colitis. • Mechanism involved anti-inflammatory and antioxidant effects dose- dependently. • It suppressed malondialdehyde and restored reduced glutathione levels. • It reduced inflammatory markers levels and histological changes.

Nagib, Marwa M. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Misr International University, Cairo (Egypt); Tadros, Mariane G., E-mail: mirogeogo@yahoo.com [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt); ELSayed, Moushira I. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Misr International University, Cairo (Egypt); Khalifa, Amani E. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)

2013-08-15T23:59:59.000Z

458

Effect of In Vivo Nicotine Exposure on Chlorpyrifos Pharmacokinetics and Pharmacodynamics in Rats  

SciTech Connect (OSTI)

Routine use of tobacco products may modify physiological and metabolic functions, including drug metabolizing enzymes, which may impact the pharmacokinetics of environmental contaminants. Chlorpyrifos is an organophosphorus (OP) insecticide that is bioactivated to chlorpyrifos-oxon, and manifests its neurotoxicity by inhibiting acetylcholinesterase (AChE). The objective of this study was to evaluate the impact of repeated nicotine exposure on the pharmacokinetics of chlorpyrifos (CPF) and its major metabolite, 3,5,6-trichloro-2-pyridinol (TCPy) in blood and urine and also to determine the impact on cholinesterase (ChE) activity in plasma and brain. Animals were exposed to 7-daily doses of either 1 mg nicotine/kg or saline (sc), and to either a single oral dose of 35 mg CPF/kg or a repeated dose of 5 mg CPF/kg/day for 7 days. Groups of rats were then sacrificed at multiple time-points after receiving the last dose of CPF. Repeated nicotine and CPF exposures resulted in enhanced metabolism of CPF to TCPy, as evidenced by increases in the measured TCPy concentration and AUC in blood. However, there was no significant difference in the amount of TCPy (free or total) excreted in the urine. The extent of brain acetylcholinesterase (AChE) inhibition was reduced due to nicotine co-exposure consistent with an increase in CYP450-mediated dearylation (detoxification) versus desulfuration. It was of interest to note that the impact of nicotine co-exposure was experimentally observed only after repeated CPF doses. Physiologically based pharmacokinetic model simulations of CPF-oxon concentrations in blood and brain were predicted to be lower in nicotine treated groups, which were simulated by increasing the dearylation Vmax based upon previously conducted in vitro metabolism studies. These results were consistent with the experimental data. The current study demonstrated that repeated nicotine exposure could alter CPF metabolism in vivo, further modulating brain AChE inhibition.

Lee, Sookwang; Poet, Torka S.; Smith, Jordan N.; Busby-Hjerpe, Andrea L.; Timchalk, Charles

2010-03-30T23:59:59.000Z

459

/sup 51/Cr-EDTA: a marker of early intestinal rejection in the rat  

SciTech Connect (OSTI)

Intestinal permeability was studied after accessory intestinal transplantation in Lewis rats. Five groups were evaluated: Group 1--isografts (N = 6); Group 2--Lewis X Brown Norway F1 (LBN-F1) allografts (N = 6); Group 3--isografts treated with CsA 2 mg/kg/day X 10 days (N = 6); Group 4--LBN-F1 allografts treated with CsA 2 mg/kg/day X 10 days (N = 6); Group 5--LBN-F1 allografts treated with CsA 4 mg/kg/day X 28 days (N = 6). Chromium-labeled ethylenedimianetetraacetate (/sup 51/Cr-EDTA) was given through the proximal stoma of the graft. Renal clearance of /sup 51/Cr-EDTA and mucosal biopsies were followed post-transplant. The biopsies of the intestinal graft showed no rejection in Groups 1, 3, and 5; fulminant rejection in Group 2; and mild atypical rejection in Group 4. /sup 51/Cr-EDTA clearance was elevated in all groups during the first 7 days post-transplant. Thereafter, /sup 51/Cr-EDTA excretion fell to lower levels in the animals with histologically normal grafts (Groups 1, 3, and 5). /sup 51/Cr-EDTA excretion in Group 4 was increased with the first histological evidence of rejection on Day 14 and remained elevated until sacrifice (P less than 0.02 compared to Groups 3 and 5). A transient permeability defect occurs after intestinal grafting. Once the graft has recovered from this injury, /sup 51/Cr-EDTA is a sensitive marker for intestinal rejection.

Grant, D.; Lamont, D.; Zhong, R.; Garcia, B.; Wang, P.; Stiller, C.; Duff, J.

1989-05-01T23:59:59.000Z

460

Stimulation of dopamine synthesis and activation of tyrosine hydroxylase by phorbol diesters in rat striatum  

SciTech Connect (OSTI)

In rat striatal synaptosomes, 4..beta..-phorbol 12-myristate 13-acetate (PMA) and 4 ..beta..-phorbol 12,13-dibutyrate (PDBu), two activators of Ca/sup 2 +/-phospholipid-dependent protein kinase (protein kinase C) increased dopamine (DA) synthesis measured by following the release of /sup 14/CO/sub 2/ from L-(1-/sup 14/C) tyrosine. Maximal stimulation (21-28% increase of basal rate) was produced by 0.5 ..mu..M PMA and 1 ..mu..M PDBu. 4 ..beta..-Phorbol and 4 ..beta..-phorbol 13-acetate, which are not activators of protein kinase C, were ineffective at 1 ..mu..M. PMA did not change the release of /sup 14/CO/sub 2/ from L-(1-/sup 14/C)DOPA. Addition of 1 mM EGTA to a Ca/sup 2 +/-free incubation medium failed to affect PMA stimulation. KCl (60 mM) enhanced DA synthesis by 25%. Exposure of synaptosomes to either PMA or PDBu prior to KCl addition resulted in a more than additive increase (80-100%) of DA synthesis. A similar synergistic effect was observed when the phorbol diesters were combined with either veratridine or d-amphetamine but not with forskolin and dibutyryl cyclic AMP. Pretreatment of striatal synaptosomes with phorbol diesters produced an activation of tyrosine hydroxylase (TH) associated with a 60% increase of the Vmax and a decrease of the Km for the pterine cofactor 6-methyl-5,6,7,8-tetrahydropterin. These results indicate that protein kinase C participates in the regulation of striatal TH in situ and that its activation may act synergistically with DA releasing agents in stimulating DA synthesis. 37 references, 3 figures, 3 tables.

Onali, P.; Olianas, M.C.

1987-03-23T23:59:59.000Z

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
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461

Involvement of calcium-sensing receptor in ischemia/reperfusion-induced apoptosis in rat cardiomyocytes  

SciTech Connect (OSTI)

The calcium-sensing receptor (CaR) is a seven-transmembrane G-protein coupled receptor, which activates intracellular effectors, for example, it causes inositol phosphate (IP) accumulation to increase the release of intracellular calcium. Although intracellular calcium overload has been implicated in the cardiac ischemia/reperfusion (I/R)-induced apoptosis, the role of CaR in the induction of apoptosis has not been fully understood. This study tested the hypothesis that CaR is involved in I/R cardiomyocyte apoptosis by increasing [Ca{sup 2+}]{sub i}. The isolated rat hearts were subjected to 40-min ischemia followed by 2 h of reperfusion, meanwhile GdCl{sub 3} was added to reperfusion solution. The expression of CaR increased at the exposure to GdCl{sub 3} during I/R. By laser confocal microscopy, it was observed that the intracellular calcium was significantly increased and exhibited a collapsed {delta}{psi} {sub m}, as monitored by 5,5',6,6'-tetrachloro-1,1',3,3'- tetraethylbenzimidazolcarbocyanine iodide (JC-1) during reperfusion with GdCl{sub 3}. Furthermore, the number of apoptotic cells was significantly increased as shown by TUNEL assay. Typical apoptotic cells were observed with transmission electron microscopy in I/R with GdCl{sub 3} but not in the control group. The expression of cytosolic cytochrome c and activated caspase-9 and caspase-3 was significantly increased whereas the expression of mitochondrial cytochrome c significantly decreased in I/R with GdCl{sub 3} in comparison to the control. In conclusion, these results suggest that CaR is involved in the induction of cardiomyocyte apoptosis during ischemia/reperfusion through activation of cytochrome c-caspase-3 signaling pathway.

Zhang Weihua [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Fu Songbin [Department of Genetics, Harbin Medical University, Harbin 150086 (China); Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150086 (China); Lu Fanghao [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China)]. E-mail: lufanghao1973@yahoo.com.cn; Wu Bo [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Gong Dongmei [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Pan, Zhen-wei [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Lv Yanjie [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Zhao Yajun [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Li Quanfeng [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Wang Rui [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Department of Biology, Lakehead University, Thunder Bay, Ont., P7B5E1 (Canada); Yang Baofeng [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150086 (China); Xu Changqing [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China) and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150086 (China)]. E-mail: xucq@163.com

2006-09-08T23:59:59.000Z

462

Morphine-6-glucuronide: analgesic effects and receptor binding profile in rats  

SciTech Connect (OSTI)

The antinociceptive effects of morphine-6-glucuronide (M6G) were examined in two animal models of pain, the tail immersion test (reflex withdrawal to noxious heat) and the formalin test (behavioral response to minor tissue injury). In the tail immersion test, M6G produced and increase in withdrawal latency that rose rapidly between 0.01 and 0.025 ug ICV or 1 and 2 mg/kg SC. A further increase occurred at doses greater than 0.2 ug ICV or 4 mg/kg SC and was associated with marked catelepsy and cyanosis. Naloxone, 0.1 mg/kg SC, shifted the lower component of the dose-effect relation by a factor of 24. In the formalin test, 0.01 ug M6G ICV produced hyperalgesia, while between 0.05 and 0.2 ug ICV, antinociception increased rapidly without toxicity. The dose effect relations for hyperalgesia and antinociception were shifted to the right by factors of 20- and 3-fold, respectively. By comparison, ICV morphine was 60 (formalin test) to 145-200 (tail immersion test) times less potent than M6G. At sub-nanomolar concentrations, M6G enhanced the binding of (/sup 3/H)-etorphine, (/sup 3/H)-dihydromorphine and (/sup 3/H)-naloxone to rat brain membrane receptors by 20-40%. At higher concentrations, M6G displaced each ligand from binding sites, with K/sub i/ values of about 30 nM, as compared to morphine K/sub i/ values of about 3 nM.

Abbott, F.V.; Palmour, R.M.

1988-01-01T23:59:59.000Z

463

Neurogenic period of ascending tract neurons in the upper lumbar spinal cord of the rat  

SciTech Connect (OSTI)

Although the neurogenic period for neurons in the lumbar spinal cord has been clearly established (Days 12 through 16 of gestation), it is not known when the neurogenesis of ascending tract neurons is completed within this period. The purpose of the present study was to determine the duration of the neurogenic period for projection neurons of the ascending tracts. To label neurons undergoing mitosis during this period, tritiated thymidine was administered to fetal rats on Embryonic (E) Days E13 through E16 of gestation. Ascending tract neurons of the lumbar cord were later (Postnatal Days 40-50) labeled in each animal with a retrograde tracer, Fluoro-Gold, applied at the site of a hemisection at spinal cord segment C3. Ascending tract neurons which were undergoing mitosis in the upper lumbar cord were double labeled, i.e., labeled with both tritiated thymidine and Fluoro-Gold. On Day E13, 89-92% of the ascending tract neurons were double labeled; on Day E14, 35-37%; and on Day E15, 1-4%. Results showed, then, that some ascending tract neurons were double labeled through Day E15 and were, therefore, proliferating in the final one-third of the neurogenic period. Ascending tract neurons proliferating on Day E15 were confined to laminae III, IV, V, and X and the nucleus dorsalis. Long tract neurons in the superficial dorsal horn (laminae I and II), on the other hand, were found to have completed neurogenesis on Day E14 of gestation. Results of the present study show that spinal neurogenesis of ascending projection neurons continues throughout most of the neurogenic period and does not completely follow the well-established ventral to dorsal gradient.

Nandi, K.N.; Beal, J.A.; Knight, D.S. (Louisiana State Univ. Medical Center, Shreveport (USA))

1990-02-01T23:59:59.000Z

464

BMC Bioinformatics Prediction of novel miRNAs and associated  

E-Print Network [OSTI]

Sherrier3 , Andrew Farmer4 , Greg May4 , Blake C Meyers3 , Dong Xu1 and Gary Stacey*2 Addresses: 1 Digital@ncgr.org; Blake C Meyers - meyers@dbi.udel.edu; Dong Xu - xudong@missouri.edu; Gary Stacey* - staceyg

Green, Pamela

465

A mi-chemin entre analyse complexe et superanalyse  

E-Print Network [OSTI]

In the framework of superanalysis we get a functions theory close to complex analysis, under a suitable condition (A) on the real superalgebras in consideration (this condition is a generalization of the classical relation 1 + i^2 = 0 in C). Under the condition (A), we get an integral representation formula for the superdifferentiable functions.We give a result of Hartogs type of separated superdifferentiability, a continuation theorem of Hartogs-Bochner type and a Liouville theorem for the superdifferentiable functions.

Pierre Bonneau; Anne Cumenge

2012-01-04T23:59:59.000Z

466

Mi Ilard W. Hall, Director Volume 10, Number 3  

E-Print Network [OSTI]

questioned about what the Office of Water Research and Technology (OWRT) program has produced and what it has that produced the state's 1971 Water Planning Framework Study. It was also involved directly in the 1975 "Level of the Nebraska Water Resources Center, at legislative authorization hearings on water resources research

Nebraska-Lincoln, University of

467

Aquaculture University of MiAMi rosenstiel school  

E-Print Network [OSTI]

, non-governmental organization, and the general public's environmental and regulatory concerns in unprotected areas offshore. And, they are constantly monitoring environmental impacts and exploring ways is effective in preventing impact on the surrounding environ- ment. the future Remarkably, cobia growth rates

Miami, University of

468

EV Community Readiness projects: Clean Energy Coalition (MI...  

Broader source: Energy.gov (indexed) [DOE]

link the Michigan PEV Community Readiness Plan to relevant websites and other appropriate media outlets; incorporate the Plan into the PEV Taskforce website. Clean Cities Recovery...

469

Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet)  

U.S. Energy Information Administration (EIA) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2007 10,998 9,933 10,998 10,643 10,998through 1996)DecadeYear Jan670,174 674,124

470

Sault St. Marie, MI Natural Gas Exports to Canada  

Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelinesProved ReservesFeet) YearPriceThousandThousand CubicChileFeet)Thousand2,044 4,011

471

St. Clair, MI Natural Gas Exports to Canada  

Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelinesProved ReservesFeet)per Thousand Cubic Feet) Decade Year-0DecadeThousand3612,369

472

St. Clair, MI Natural Gas Imports by Pipeline from Canada  

Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelinesProved ReservesFeet)per Thousand Cubic Feet) Decade

473

Marysville, MI Natural Gas Imports by Pipeline from Canada  

Gasoline and Diesel Fuel Update (EIA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines About U.S.30Natural Gas Glossary529 6330 0 14343Decade81 170 115 89 1164,925 22,198

474

Marysville, MI Natural Gas Pipeline Imports From Canada (Dollars per  

Gasoline and Diesel Fuel Update (EIA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines About U.S.30Natural Gas Glossary529 6330 0 14343Decade81 170 115 89 1164,925Year Jan

475

Marysville, MI Natural Gas Pipeline Imports From Canada (Dollars per  

Gasoline and Diesel Fuel Update (EIA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines About U.S.30Natural Gas Glossary529 6330 0 14343Decade81 170 115 89 1164,925Year

476

Marysville, MI Natural Gas Pipeline Imports From Canada (Million Cubic  

Gasoline and Diesel Fuel Update (EIA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines About U.S.30Natural Gas Glossary529 6330 0 14343Decade81 170 115 89 1164,925YearFeet)

477

MINOS Experiment and NuMI Beam Home Page  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation InInformation InExplosion Monitoring:Home|

478

Detroit, MI Natural Gas Imports by Pipeline from Canada  

Gasoline and Diesel Fuel Update (EIA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines About U.S.30Natural Gas Glossary529 633 622 56623 4623 42YearDelawareDetails of

479

DOE - Office of Legacy Management -- Carboloy Co - MI 12  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou are here Home »Hill -Elmore - OHCalliteCarboloy Co

480

DOE - Office of Legacy Management -- Detrex Corp - MI 10  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou are here Home »HillNY 28

Note: This page contains sample records for the topic "democ rat mi" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

DOE - Office of Legacy Management -- Michigan Velsicol Chemical Corp - MI  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou are here HomeGunnison-EngineerSelling Corp03

482

DOE - Office of Legacy Management -- Oliver Corp - MI 11  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou are herePA 3003A01EngineeringOlinOliver

483

DOE - Office of Legacy Management -- Star Cutter Corp - MI 15  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou areDowntown Site - MO 02 FUSRAP

484

DOE - Office of Legacy Management -- University of Michigan - MI 08  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou areDowntown Site -Miami - FL 0-01 FUSRAP

485

DOE - Office of Legacy Management -- Westinghouse Naval Ordnance - MI 02  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou areDowntown Site -Miami -NewPlant - PANaval Ordnance

486

DOE - Office of Legacy Management -- Wolverine Tube Division - MI 05  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou areDowntown Site -Miami -NewPlant -Woburn

487

Marysville, MI Natural Gas Pipeline Imports From Canada (Million Cubic  

Gasoline and Diesel Fuel Update (EIA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines About U.S.30 2013 Macroeconomic team: Kay Smith, RussFoot)per ThousandFeet)

488

REC Silicon formerly ASiMI | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia:FAQ < RAPID Jump to: navigation, search RAPIDColoradosource History View New Pages Recent36Silicon formerly

489

Marysville, MI Natural Gas Pipeline Imports From Canada (Million Cubic  

U.S. Energy Information Administration (EIA) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2007 10,998 9,933 10,998 10,643 10,998 10,643NorwayBase480 530Decade Year-0 Year-1DecadeFeet) Year Jan

490

Toxicology Studies on Lewisite and Sulfur Mustard Agents: Subchronic Toxicity of Sulfur Mustard (HD) In Rats Final Report  

SciTech Connect (OSTI)

Occupational health standards have not been established for sulfur mustard [bis(2- chlorethyl)-sulfide], a strong alkylating agent with known mutagenic properties. Seventytwo Sprague-Dawley rats of each sex, 6-7 weeks old, were divided into six groups (12/group/ sex) and gavaged with either 0, 0.003 , 0.01 , 0.03 , 0.1 or 0.3 mg/kg of sulfur mustard in sesame oil 5 days/week for 13 weeks. No dose-related mortality was observed. A significant decrease (P ( 0.05) in body weight was observed in both sexes of rats only in the 0.3 mg/kg group. Hematological evaluations and clinical chemistry measurements found no consistent treatment-related effects at the doses studied. The only treatment-related lesion associated with gavage exposure upon histopathologic evaluation was epithelial hyperplasia of the forestomach of both sexes at 0.3 mg/kg and males at 0.1 mg/kg. The hyperplastic change was minimal and characterized by cellular disorganization of the basilar layer, an apparent increase in mitotic activity of the basilar epithelial cells, and thickening of the epithelial layer due to the apparent increase in cellularity. The estimated NOEL for HD in this 90-day study is 0.1 mg/kg/day when administered orally.

Sasser, L. B.; Miller, R. A.; Kalkwarf, D, R.; Buschbom, R. L.; Cushing, J. A.

1989-06-30T23:59:59.000Z

491

Neuropeptide Y-like immunoreactivity in rat cranial parasympathetic neurons: coexistence with vasoactive intestinal peptide and choline acetyltransferase  

SciTech Connect (OSTI)

Neuropeptide Y (NPY) is widely distributed in the sympathetic nervous system, where it is colocalized with norepinephrine. The authors report here that NPY-immunoreactive neurons are also abundant in three cranial parasympathetic ganglia, the otic, sphenopalatine, and ciliary, in the rat measured by radioimmunoassay. High-performance liquid chromatographic analysis of the immunoreactive material present in the otic ganglion indicates that this material is very similar to porcine NPY and indistinguishable from the NPY-like immunoreactivity present in rat sympathetic neurons. These findings raise the possibility that NPY acts as a neuromodulator in the parasympathetic as well as the sympathetic nervous system. In contrast to what had been observed for sympathetic neurons, NPY-immunoreactive neurons in cranial parasympathetic ganglia do not contain detectable catecholamines or tyrosine hydroxylase immunoreactivity, and many do contain immunoreactivity for vasoactive intestinal peptide and/or choline acetyltransferase. These findings suggest that there is no simple rule governing coexpression of NPY with norepinephrine, acetylcholine, or vasoactive intestinal peptide in autonomic neurons. Further, while functional studies have indicated that NPY exerts actions on the peripheral vasculature which are antagonistic to those of acetylcholine and vasoactive intestinal peptide, the present results raise the possibility that these three substances may have complementary effects on other target tissues.

Leblanc, G.C.; Trimmer, B.A.; Landis, S.C.

1987-05-01T23:59:59.000Z

492

Immunization with FSH? fusion protein antigen prevents bone loss in a rat ovariectomy-induced osteoporosis model  

SciTech Connect (OSTI)

Highlights: •A GST-FSH fusion protein was successfully expressed in E. coli. •Immunization with GST-FSH antigen can raise high-titer anti-FSH polyclonal sera. •Anti-FSH polyclonal sera can neutralize osteoclastogenic effect of FSH in vitro. •FSH immunization can prevent bone loss in a rat osteoporosis model. -- Abstract: Osteoporosis, a metabolic bone disease, threatens postmenopausal women globally. Hormone replacement therapy (HTR), especially estrogen replacement therapy (ERT), is used widely in the clinic because it has been generally accepted that postmenopausal osteoporosis is caused by estrogen deficiency. However, hypogonadal ? and ? estrogen receptor null mice were only mildly osteopenic, and mice with either receptor deleted had normal bone mass, indicating that estrogen may not be the only mediator that induces osteoporosis. Recently, follicle-stimulating hormone (FSH), the serum concentration of which increases from the very beginning of menopause, has been found to play a key role in postmenopausal osteoporosis by promoting osteoclastogenesis. In this article, we confirmed that exogenous FSH can enhance osteoclast differentiation in vitro and that this effect can be neutralized by either an anti-FSH monoclonal antibody or anti-FSH polyclonal sera raised by immunizing animals with a recombinant GST-FSH? fusion protein antigen. Moreover, immunizing ovariectomized rats with the GST-FSH? antigen does significantly prevent trabecular bone loss and thereby enhance the bone strength, indicating that a FSH-based vaccine may be a promising therapeutic strategy to slow down bone loss in postmenopausal women.

Geng, Wenxin; Yan, Xingrong; Du, Huicong; Cui, Jihong; Li, Liwen, E-mail: liven@nwu.edu.cn; Chen, Fulin, E-mail: chenfl@nwu.edu.cn

2013-05-03T23:59:59.000Z