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1

City of Gridley, California (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

Gridley, California (Utility Company) Gridley, California (Utility Company) Jump to: navigation, search Name City of Gridley Place California Utility Id 7677 Utility Location Yes Ownership M NERC Location WECC NERC WECC Yes Activity Distribution Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Demand Commercial Commercial General Commercial Commercial Industrial Industrial Outdoor Lighting- 150W Lighting Outdoor Lighting- 200W Lighting Outdoor Lighting- 400W Lighting Residential Residential Residential- Life Support Program Residential Average Rates Residential: $0.1690/kWh Commercial: $0.1680/kWh

2

City of Gridley Utilities - PV Buy Down Program | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Gridley Utilities - PV Buy Down Program Gridley Utilities - PV Buy Down Program City of Gridley Utilities - PV Buy Down Program < Back Eligibility Commercial Residential Savings Category Solar Buying & Making Electricity Maximum Rebate Program is currently on hold Program Info State California Program Type Utility Rebate Program Rebate Amount Program is currently on hold Provider City of Gridley Utilities '''''Funding for this program is currently exhausted. The summary below describes incentives as they were in 2010 and 2011. Incentive levels for the next funding round are still unknown.''''' City of Gridley is providing rebates of $2.80/W for their customers installing PV systems. Individual rebates are limited to $5,600 per system, and the utility will award a total of $41,700 in rebates per year. Systems

3

Gridley Ethanol Demonstration Project Utilizing Biomass Gasification Technology: Pilot Plant Gasifier and Syngas Conversion Testing; August 2002 -- June 2004  

DOE Green Energy (OSTI)

This report is part of an overall evaluation of using a modified Pearson Pilot Plant for processing rice straw into syngas and ethanol and the application of the Pearson technology for building a Demonstration Plant at Gridley. This report also includes information on the feedstock preparation, feedstock handling, feedstock performance, catalyst performance, ethanol yields and potential problems identified from the pilot scale experiments.

Not Available

2005-02-01T23:59:59.000Z

4

Fish Bulletin 140. The Marine Environment offshore From Point Loma, San Diego County  

E-Print Network (OSTI)

and Animals Observed offshore from Point Loma February andand Animals Observed offshore from Point Loma February andand Animals Observed offshore from Point Loma February and

Turner, Charles H; Ebert, Earl E; Given, Robert R

1967-01-01T23:59:59.000Z

5

PROTRACTED LOW DOSE PHOTON AND SIMULATED SOLAR FLARE  

NLE Websites -- All DOE Office Websites (Extended Search)

PROTRACTED LOW DOSE PHOTON AND SIMULATED SOLAR FLARE PROTRACTED LOW DOSE PHOTON AND SIMULATED SOLAR FLARE PROTON EFFECTS ON CYTOKINE/CHEMOKINE EXPRESSION AFTER WHOLE-BODY IRRADIATION Asma Rizvi 2 , George Coutrakon 1 , James M. Slater 1 , Michael J. Pecaut 1,2 and Daila S. Gridley 1,2 Departments. of 1 Radiation Medicine and 2 Biochemistry & Microbiology Loma Linda University & Medical Center, Loma Linda, CA 92354 Astronauts are exposed to low dose/low dose rate radiation (LDR) and may also be acutely irradiated during a solar particle event (SPE). The biological effects of LDR alone and when combined with a solar particle event, are not yet clearly understood. Previous studies have shown that irradiation can have adverse effects on T cells. The reactive oxygen species (ROS) that are produced as a result of radiation can alter or damage the

6

LOW DOSE PHOTON RADIATION-INDUCED CHANGES IN T HELPER LYMPHOCYTES  

NLE Websites -- All DOE Office Websites (Extended Search)

LOW DOSE PHOTON RADIATION-INDUCED CHANGES IN T HELPER LYMPHOCYTES LOW DOSE PHOTON RADIATION-INDUCED CHANGES IN T HELPER LYMPHOCYTES Daila S. Gridley 1,2 , Asma Rizvi 2 , Xian Luo 1 , Adeola Y. Makinde 2 , Steve Rightnar 1 , Jian Tian 1 , Melba L. Andres 1 , James M. Slater 1 , and Michael J. Pecaut 1,2 Departments of 1 Radiation Medicine and 2 Biochemistry & Microbiology Loma Linda University and Medical Center, Loma Linda, CA 92354 USA Health risks due to protracted low dose irradiation remain unclear. This project investigates T helper (Th) lymphocyte function and the cellular milieu in which they reside under conditions of low dose, low- linear energy transfer (LET) radiation exposure. The Th cells are important because they secrete cytokines essential for generating optimal immune defenses against tumor, virus-infected, and other

7

Loma, Montana: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

Loma, Montana: Energy Resources Loma, Montana: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 47.9369164°, -110.5035455° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":47.9369164,"lon":-110.5035455,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

8

Low-dose Photons Modify CD4+ T Cell Signaling Response to Simulated Solar  

NLE Websites -- All DOE Office Websites (Extended Search)

Photons Modify CD4+ T Cell Signaling Response to Simulated Solar Photons Modify CD4+ T Cell Signaling Response to Simulated Solar Particle Event Protons Daila Gridley Loma Linda University and Medical Center Abstract Purpose: Astronauts on missions are exposed to low-dose/low-dose (LDR) radiation and could receive high doses during solar particle events (SPE). This study investigated T cell function in response to LDR radiation and simulated SPE (sSPE) protons, alone and in combination. Materials and methods: C57BL/6 mice received LDR γ-radiation (57Co) to a total dose of 0.01 Gray (Gy) at 0.0179 cGy/h, either with or without subsequent exposure to 1.7 Gy simulated SPE (sSPE) protons delivered over 36 h. On days 4 and 21 post-exposure, three functional pathways were studied using negatively isolated/anti-CD3 activated splenic CD4+ T cells:

9

Gene Expression Analysis of Apoptosis and Oxidative Stress in Mouse Brain  

NLE Websites -- All DOE Office Websites (Extended Search)

Analysis of Apoptosis and Oxidative Stress in Mouse Brain Analysis of Apoptosis and Oxidative Stress in Mouse Brain After Low-dose and Acute Radiation Exposure Daila Gridley Loma Linda University & Medical Center Abstract Purpose: 1) To examine the induction of oxidative stress and apoptosis-associated gene expression profiles in brain after whole-body irradiation with low-dose/low-dose-rate (LDR) photons and acute exposure to photons 2) to compare these radiation-induced effects with those produced by LDR and acute exposure to protons. Material and Methods: C57BL/6 mice were exposed to 2 Gy of photons or protons at 0.8 Gy/min and 0.9 Gy/min, respectively, both with and without pre-exposure to 0.01 Gy LDR γ-rays (57Co) at 0.03 cGy/h. Brain tissues were harvested and quick-frozen for analyses by quantitative RTPCR at 56

10

Low-dose Photon and Simulated Solar Particle Event Proton Effects on Foxp3+  

NLE Websites -- All DOE Office Websites (Extended Search)

Photon and Simulated Solar Particle Event Proton Effects on Foxp3+ Photon and Simulated Solar Particle Event Proton Effects on Foxp3+ Treg Cells and Other Leukocytes Daila Gridley Loma Linda University and Medical Center Abstract Purpose: Radiation is a major factor in the spaceflight environment that can compromise immune defense mechanisms. Astronauts on missions are continuously exposed to lowdose/ low-dose-rate (LDR) radiation and may receive relatively high doses during a solar particle event (SPE) that consists primarily of protons. However, there are very few reports in which LDR photons were combined with protons. The goal of this study was to determine whether exposure to LDR γ-rays would modulate the effect of proton radiation mimicking an SPE. Materials and Methods: C57BL/6 mice were exposed to 1.7 Gy simulated SPE

11

2010 DOE National Science Bowl Photos - Mira Loma High School...  

Office of Science (SC) Website

FeedbackShare Page The Mira Loma High School team, from Sacramento, CA, works on the oil spill challenge at the National Science Bowl in Washington, DC. Left to right: Andrew...

12

DOE - Office of Legacy Management -- Loma Mill - CO 03  

Office of Legacy Management (LM)

Loma Mill - CO 03 Loma Mill - CO 03 FUSRAP Considered Sites Site: Loma Mill (CO.03 ) Designated Name: Alternate Name: Location: Evaluation Year: Site Operations: Site Disposition: Radioactive Materials Handled: Primary Radioactive Materials Handled: Radiological Survey(s): Site Status: This site is one of a group of 77 FUSRAP considered sites for which few, if any records are available in their respective site files to provide an historical account of past operations and their relationship, if any, with MED/AEC operations. Reviews of contact lists, accountable station lists, health and safety records and other documentation of the period do not provide sufficient information to warrant further search of historical records for information on these sites. These site files remain "open" to

13

Aquifer test at Comore Loma No. 4, Idaho Falls, Idaho  

DOE Green Energy (OSTI)

An aquifer test was conducted at Comore Loma Well {number_sign}4 to determine the aquifer hydraulic characteristics at this location on July 11 and 12, 1991. Water was withdrawn from Comore Loma Well {number_sign}4 at approximately 850 gallons per minute for 8 hours while monitoring the water level in the plumping well and an observation well 930 ft away. The pumped well showed over 12 ft of drawdown with no discernable drawdown in the observation well. The drawdown in the pumped well was nearly instantaneous, showing little additional drawdown after 1 minute. The transmissivity was calculated to be approximately 140,000 ft{sup 2}/day using the Jacob solution. This gives a hydraulic conductivity of 1300 ft/day for the 110 ft interval tested. The high transmissivity and geologic setting suggest the aquifer may in part produce water from the Snake River Plain aquifer. However, the warm water temperature (71{degrees}F) indicates the presence of a geothermal source typical of the foothills aquifer. The storage coefficient could not be calculated since no water level decline was detected in the observation well.

Hubbell, J.M.

1991-12-01T23:59:59.000Z

14

Mira Loma High School and Hopkins Junior High School from California Win  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Mira Loma High School and Hopkins Junior High School from Mira Loma High School and Hopkins Junior High School from California Win U.S. Department of Energy National Science Bowl Mira Loma High School and Hopkins Junior High School from California Win U.S. Department of Energy National Science Bowl May 4, 2009 - 12:00am Addthis WASHINGTON, DC - High school and middle school teams from California won the 2009 U.S. Department of Energy (DOE) National Science Bowl® today at the National Building Museum in Washington. Mira Loma High School from Sacramento beat Lexington High School from Lexington, Massachusetts in the high school national championship match. Hopkins Junior High School from Fremont, California beat Jonas Clarke Middle School from Lexington, Massachusetts in the middle school national championship match.

15

The October 17, 1989, Loma Prieta Earthquake: Effects on Selected Power and Industrial Facilities  

Science Conference Proceedings (OSTI)

The magnitude 7.1 Loma Prieta earthquake created moderate to strong ground shaking over an area of more than 5000 km(2), including the southern portion of the San Francisco Bay cities and centers of population and industry surrounding Monterey Bay. This report summarizes the effects of the earthquake on a large inventory of structures and equipment installations relevant to the electric power industry, including thermal-electric power plants, substations, nonpower utility operations, and industrial sites.

1991-09-27T23:59:59.000Z

16

Gridley, California: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

3637773°, -121.6935833° 3637773°, -121.6935833° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":39.3637773,"lon":-121.6935833,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

17

Sustainable disaster recovery of historic buildings, the case of San Francisco after Loma Prieta earthquake  

E-Print Network (OSTI)

Recovery from disaster is a challenging period for any community. Long-term recovery is important, especially in relation to the built heritage, but it is among the least explored phases of disaster. Identifying past problems is needed to reduce future recovery complications. This study investigates the long-term recovery of public and Non-Government Organizations (NGO) owned historic buildings after an earthquake in the light of chosen sustainability variables. It examines San Francisco after the 1989 Loma Prieta earthquake as a case study and analyzes time needs, community participation, and maintenance of historic character, to identify whether historic buildings faced special issues and the variables involved. The study uses different methods. It statistically compares data for a sample of public and NGO owned buildings in San Francisco and then analyzes the dynamics of recovery for three buildings that faced delays. The study has found that historic buildings faced delays in recovery but such delays were sometimes the results of major rehabilitation projects, thus having long-term benefits. There are many variables in the recovery process that delay historic buildings and can be addressed to reduce future delays, which are mostly results of the context, process, and players. Time needs for the recovery of buildings are affected by their function, damage level, and status. Also, the sustainability of the process needs to be addressed, mainly in terms of the way historic buildings are valued, and the degree to which such valuation allows them to be part of the heritage of the community at large.

Al-Nammari, Fatima M.

2003-05-01T23:59:59.000Z

18

Tax Credits, Rebates & Savings | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Gridley Utilities - PV Buy Down Program California Commercial Residential Solar Buying & Making Electricity City of Gridley Utilities City of Gridley Utilities - PV Buy Down...

19

2010 DOE National Science Bowl Photos - Mira Loma High School...  

Office of Science (SC) Website

team from Sacramento, CA works on the oil spill challenge at the National Science Bowl in Washington, DC. Left to right: Edward Lee, Andrew Chen, Anish Khare, Russ Islam Photograph...

20

2010 DOE National Science Bowl Photos - Mira Loma High School...  

Office of Science (SC) Website

Facebook Facebook External link Share with Twitter Twitter External link Share with Google Bookkmarks Google Bookmarks External link Email a Friend Email link to: send 2010 DOE...

Note: This page contains sample records for the topic "daila gridley loma" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

STATEMENT OF CONSIDERATIONS REQUEST BY STONE & WEBSTER FOR AN...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

is to prepare a feasibility study for economical conversion of rice straw to ethanol near Gridley, California. The ultimate goal of this project is to develop a...

22

Mira Loma High School and Hopkins Junior High School from California...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Lexington High School from Lexington, Massachusetts. Team members include: Jaeyoon Lee, Noah Arbesfeld, Joshua Leung, Christopher Teng, and Kyumin Lee and coaches Nicholas Gould...

23

The Loma Prieta Earthquake of October 17, 1989, A UCSC Student Oral History Documentary Projec  

E-Print Network (OSTI)

lot of expertise in disaster response. But they dont have aa reevaluation of their disaster responses. FEMA has to do aofficial emergency response to natural disasters. In reading

Reti, Irene; Regional History Project, UCSC Library

2006-01-01T23:59:59.000Z

24

The Loma Prieta Earthquake of October 17, 1989, A UCSC Student Oral History Documentary Projec  

E-Print Network (OSTI)

indifference. I remember just taking stock of the situationindifference. I remember just taking stock of the situation

Reti, Irene; Regional History Project, UCSC Library

2006-01-01T23:59:59.000Z

25

Th Cell Gene Expression and Function in Response to Low Dose and Acute Radiation  

SciTech Connect

FINAL TECHNICAL REPORT Supported by the Low Dose Radiation Research Program, Office of Science U.S. Department of Energy Grant No. DE-FG02-07ER64345 Project ID: 0012965 Award Register#: ER64345 Project Manager: Noelle F. Metting, Sc.D. Phone: 301-903-8309 Division SC-23.2 noelle.metting@science.doe.gov Submitted March 2012 To: https://www.osti.gov/elink/241.3.jsp Title: Th Cell Gene Expression and Function in Response to Low Dose and Acute Radiation PI: Daila S. Gridley, Ph.D. Human low dose radiation data have been derived primarily from studies of space and airline flight personnel, nuclear plant workers and others exposed occupationally, as well as victims in the vicinity of atomic bomb explosions. The findings remain inconclusive due to population inconsistencies and complex interactions among total dose, dose rate, radiation quality and age at exposure. Thus, safe limits for low dose occupational irradiation are currently based on data obtained with doses far exceeding the levels expected for the general population and health risks have been largely extrapolated using the linear-nonthreshold dose-response model. The overall working hypothesis of the present study is that priming with low dose, low-linear energy transfer (LET) radiation can ameliorate the response to acute high-dose radiation exposure. We also propose that the efficacy of low-dose induced protection will be dependent upon the form and regimen of the high-dose exposure: photons versus protons versus simulated solar particle event protons (sSPE). The emphasis has been on gene expression and function of CD4+ T helper (Th) lymphocytes harvested from spleens of whole-body irradiated C57BL/6 mice, a strain that provides the genetic background for many genetically engineered strains. Evaluations of the responses of other selected cells, tissues such as skin, and organs such as lung, liver and brain were also initiated (partially funded by other sources). The long-term goal is to provide information that will be useful in estimating human health risks due to radiation that may occur during exposures in the work environment, nuclear/radiological catastrophes, as well as radiotherapy. Several papers have been published, accepted for publication or are in preparation. A number of poster and oral presentations have been made at scientific conferences and workshops. Archived tissues of various types will continue to be evaluated via funding from other sources (the DoE Low Dose Radiation Research Program, Office of Science and this specific grant will be appropriately included in the Acknowledgements of all subsequent publications/presentations). A post-doc and several students have participated in this study. More detailed description of the accomplishments is described in attached file.

Daila S. Gridley, PhD

2012-03-30T23:59:59.000Z

26

In vitro Study of the Microsporidian Parasite Loma morhua, Using Cod-derived Cells and Novel Culture Techniques.  

E-Print Network (OSTI)

??The cod populations of the Canadian Atlantic were once highly productive, generating enormous annual harvests and attracting fishing fleets from many nations. However, through the (more)

MacLeod, Michael J

2012-01-01T23:59:59.000Z

27

Naval Nuclear Propulsion Program Directorate, Washington ...  

Science Conference Proceedings (OSTI)

Naval Nuclear Propulsion Program Directorate, Washington, DC. NVLAP Lab Code: 100565-2. Address and Contact Information: Point Loma, Bldg. ...

2013-08-23T23:59:59.000Z

28

USER SATISFACTION WITH INNOVATIVE COOLING RETROFITS IN SACRAMENTO PUBLIC HOUSING  

E-Print Network (OSTI)

Director - 2 - #12;Disclaimer This report was prepared as a result of work by the staff of the California Gridley Manteca Pittsburg Citrus Heights Half Moon Bay Marina Pleasant Hill Claremont Hanford Martinez of Public Works, Engineer and/or Maintenance Department. Surveys were sent and returned via electronic mail

Diamond, Richard

29

Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study  

E-Print Network (OSTI)

Ji BT, Chow WH, Dai Q, McLaughlin JK, Benichou J, Hatch MC6(12):10811086 Zheng W, McLaughlin JK, Gridley G, Bjelke E,Ekbom A, Josefsson S, McLaughlin JK, Fraumeni JF Jr, Nyren

Gupta, Samir; Wang, Furong; Holly, Elizabeth A.; Bracci, Paige M.

2010-01-01T23:59:59.000Z

30

Contribution of Tissue Level Organization to Genomic Stability...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Tissue Level Organization to Genomic Stability Following Low Dose Gamma Irradiation Cheryl Burrell Loma Linda University Abstract Our study proposes that the level of...

31

Other Participants 2004 | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

, Evans , GA Lamp High School , Montgomery , AL Liberty Christian Academy , Jerome , ID Lincoln High School , Portland , OR Milby High School , Houston , TX Mira Loma High School...

32

Louis F. Fackler: Founding Campus Engineer, UC Sant Cruz  

E-Print Network (OSTI)

were thinking in terms of water conservation. Fackler: Yeah.Other Campus Buildings Water Conservation The Loma Prietaspearheaded energy and water conservation programs at UCSC

Fackler, Louis F.; Reti, Irene; UCSC Library, Regional History Project, UC Santa Cruz

2013-01-01T23:59:59.000Z

33

www.eia.gov  

U.S. Energy Information Administration (EIA)

J.K. Smith C Spurlock Stuart / Zimmer Lemoyne Troy Energy CTs North Medina ... Bates South McAllen Loma Alta Ranch N Edinburg Pawnee Coleto Creek Rio Hondo Ckt 74 Tomball

34

NETL F 451.1-1/1 Categorical Exclusion (CX) Designation Form  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Lomas, Webb County, Tx Colonias for Microgrids (TX) OE 14.09 Purpose of this project is to fully develop prototype renewable based micro-grid power systems for communities...

35

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

31 - 3040 of 28,905 results. Article Congratulations, 2013 National Science Bowl Winners The team from Sacramento's Mira Loma High School won the 2013 National Science Bowl in...

36

Janet and Grant Brians: Brians Ranch  

E-Print Network (OSTI)

organization, like Dale Coke. 3 I remember going and helpingmarket and deliver to Dale Coke over in San Juan [Bautista].See the oral history with Dale Coke in this series. The Loma

Farmer, Ellen

2010-01-01T23:59:59.000Z

37

STATEMENT OF CONSIDERATIONS REQUEST BY STONE & WEBSTER FOR AN ADVANCE WAIVER OF  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

STONE & WEBSTER FOR AN ADVANCE WAIVER OF STONE & WEBSTER FOR AN ADVANCE WAIVER OF DOMESTIC AND FOREIGN RIGHTS UNDER AN NREL SUBCONTRACT NO. ZCG-6-15143-01, W(A)-96-006, CH-0898 AND FOR LARGE BUSINESS LOWER-TIER SUBCONTRACTS THEREUNDER Stone & Webster Corporation has petitioned for an Advance Waiver of Patent Rights under the above-identified National Renewable Energy Laboratory (NREL) subcontract and under lower tier subcontracts entered into thereunder with parties who do not qualify for treatment under Public Law 96-517, as amended, or National Laboratories. NREL is operated by Midwest Research Institute (MRI) under the prime contract number DE-AC02- 83CH10093. The scope of the subcontract is to prepare a feasibility study for economical conversion of rice straw to ethanol near Gridley,

38

Final Base Resource Contracts - 12/29/2000  

NLE Websites -- All DOE Office Websites (Extended Search)

Contracts Contracts Last Updated 12/29/2000 No. Entity/Name Executed 1 City of Biggs 07/11/2000 1 San Juan Water District 07/11/2000 1 City of Gridley 07/14/2000 1 City of Roseville 07/26/2000 1 City of Lompoc 07/27/2000 1 Lassen Municipal Utility District 07/27/2000 1 State of California - Department of Parks/Recreation 07/28/2000 1 CSUS - Aquatic and Boat Safety Center 07/28/2000 1 Healdsburg 08/04/2000 1 City of Lodi 08/15/2000 1 California State Prison, Sacramento 08/15/2000 1 The West Side Irrigation District 08/30/2000 1 Plumas Sierra Rural Electric Cooperative 08/30/2000 1 Sacramento Municipal Utility District 09/08/2000 1 City of Redding 09/13/2000 1 Deuel Vocational Institute 09/13/2000 1 Vacaville Medical Facility, State Dept of Corrections

39

Developing Web sites for Web based expert systems: A Web engineering approach  

E-Print Network (OSTI)

Abstract: This paper presents a developing process for Web based expert systems and specifically focuses on the developing process of their corresponding Web sites. As a case study, the architecture of a Web site/application, which includes the Landfill Operation Management Advisor (LOMA) expert system, will be presented. The Web site/application is available at

Ioannis M. Dokas

2005-01-01T23:59:59.000Z

40

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Error message Error message The page you requested does not exist. For your convenience, a search was performed using the query Flash2009 19. You are here Home » Page not found Page not found Oops! The page you are looking for doesn't seem to be available. Did you find a broken link? Tell us and we'll fix it. Or maybe you meant to go somewhere else? Use the search box or links below to help guide you. Enter terms Flash2009 19 Search Showing 1971 - 1980 of 9,640 results. Article Mira Loma High School and Hopkins Junior High School from California Win U.S. Department of Energy National Science Bowl http://energy.gov/articles/mira-loma-high-school-and-hopkins-junior-high-school-california-win-us-department-energy Download Document http://energy.gov/management/downloads/document

Note: This page contains sample records for the topic "daila gridley loma" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

FermiNews - January 19, 2001  

NLE Websites -- All DOE Office Websites (Extended Search)

January 19, 2001 | Number 1 January 19, 2001 | Number 1 In This Issue | FermiNews Main Page Protons Against Cancer by Kurt Riesselmann The Loma Linda Accelerator In contrast to biology and medicine, physics is not usually considered one of the life sciences. Yet basic research in physics makes critical, though often unsung, contributions to saving lives. Fermilab's role in cancer treatment is a case in point. Last month the Loma Linda Proton Treatment Center celebrated 10 years of treating cancer patients using particle beams from a compact proton accelerator completely designed and built at Fermilab. In the decade of the Center's operation, accelerator technology from Fermilab has provided cancer therapy at Loma Linda for more than 6000 patients from around the world. Cancer is the second leading cause of death in the United States, exceeded only by heart disease. Nearly five million lives have been lost to cancer since 1990, and physicians have diagnosed almost three times as many people with cancer during the same period of time. With people living longer than ever before, their chance of developing cancer is at an all-time high.

42

Data, Feedback, & Awareness Lead to Big Energy Savings  

NLE Websites -- All DOE Office Websites (Extended Search)

energy feedback and energy feedback and "staff monitors" to reinforce commu- nication and activity led to improved routine practices and significant energy savings. Members of the Navy Region Southwest Metro San Diego regional energy management team with an example poster from their energy awareness program. (Photo courtesy FEMP/NRSMSD.) Data, Feedback, & Awareness Lead to Big Energy Savings The Navy Region Southwest Metro San Diego Area (NRSMSD) regional energy management team achieved significant energy savings at the three major complexes: Naval Base Coronado, Naval Base San Diego, and Naval Base Point Loma, result- ing largely from a well organized energy awareness program centered on energy data

43

Data, Feedback, & Awareness Lead to Big Energy Savings  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

monthly energy feedback and monthly energy feedback and "staff monitors" to reinforce commu- nication and activity led to improved routine practices and significant energy savings. Members of the Navy Region Southwest Metro San Diego regional energy management team with an example poster from their energy awareness program. (Photo courtesy FEMP/NRSMSD.) Data, Feedback, & Awareness Lead to Big Energy Savings The Navy Region Southwest Metro San Diego Area (NRSMSD) regional energy management team achieved significant energy savings at the three major complexes: Naval Base Coronado, Naval Base San Diego, and Naval Base Point Loma, result- ing largely from a well organized energy awareness program centered on energy data

44

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

31 - 3040 of 28,905 results. 31 - 3040 of 28,905 results. Article Congratulations, 2013 National Science Bowl Winners The team from Sacramento's Mira Loma High School won the 2013 National Science Bowl in dramatic fashion -- pulling ahead as the clock expired in the final round. http://energy.gov/articles/congratulations-2013-national-science-bowl-winners Download EIS-0397: Final Environmental Impact Statement Lyle Falls Fish Passage Project http://energy.gov/nepa/downloads/eis-0397-final-environmental-impact-statement Page PART 708-- DOE CONTRACTOR EMPLOYEE PROTECTION PROGRAM Criteria and Procedures for DOE Contractor Employee Protection Program http://energy.gov/oha/part-708-doe-contractor-employee-protection-program Download EIS-0218: Revised Record of Decision Proposed Nuclear Weapons Nonproliferation Policy Concerning Foreign

45

National Science Bowl Update: Teams from North Carolina and California to  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Teams from North Carolina and Teams from North Carolina and California to Compete for High School Championship National Science Bowl Update: Teams from North Carolina and California to Compete for High School Championship April 28, 2013 - 10:41pm Addthis NEWS MEDIA CONTACT 858-859-1672 Editor's Note: HD-quality b-roll from the competition is being posted online at https://vimeo.com/doescience/videos. WASHINGTON - The field of high school finalists in the Department of Energy (DOE) National Science Bowl has narrowed once more, and now only two high school teams remain in the competition. The teams remaining are: California Mira Loma High School, Sacramento North Carolina North Carolina School of Science and Mathematics (HS), Durham The first-place high school team in the academic competition will win a

46

California | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

4, 2011 4, 2011 CX-005938: Categorical Exclusion Determination Roseville Elverta (RSC-ELV) Optical Ground Wire Replacement Project CX(s) Applied: B4.6, B4.7 Date: 05/04/2011 Location(s): Sacramento, California Office(s): Western Area Power Administration-Sierra Nevada Region May 2, 2011 The Gale Ranch Middle School of San Ramon, CA, received first place at the 2011 National Science Bowl. | Energy Department Image | Photo by Dennis Brack, Contractor California Schools Sweep the 2011 National Science Bowl The Mira Loma High School of Sacramento, California, and the Gale Ranch Middle School of San Ramon, California, beat out 1,800 sciences teams from across the country to become the 2011 National Science Bowl champions today. May 2, 2011 CX-005745: Categorical Exclusion Determination

47

California Schools Sweep the 2011 National Science Bowl | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

California Schools Sweep the 2011 National Science Bowl California Schools Sweep the 2011 National Science Bowl California Schools Sweep the 2011 National Science Bowl May 2, 2011 - 6:23pm Addthis The Gale Ranch Middle School of San Ramon, CA, received first place at the 2011 National Science Bowl. | Energy Department Image | Photo by Dennis Brack, Contractor The Gale Ranch Middle School of San Ramon, CA, received first place at the 2011 National Science Bowl. | Energy Department Image | Photo by Dennis Brack, Contractor Ginny Simmons Ginny Simmons Former Managing Editor for Energy.gov, Office of Public Affairs The winners are in. The Mira Loma High School of Sacramento, California, and the Gale Ranch Middle School of San Ramon, California, beat out 1,800 sciences teams from across the country to become the 2011 National Science Bowl champions

48

Notices EIS No. 20070360, ERP No. F-BLM- J03020-00, Overland Pass Natural Gas  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

81 Federal Register 81 Federal Register / Vol. 72, No. 197 / Friday, October 12, 2007 / Notices EIS No. 20070360, ERP No. F-BLM- J03020-00, Overland Pass Natural Gas Liquids Pipeline Project (OPP), Construction and Operation of 760 mile Natural Gas Liquids Pipeline, Right-of-Way Grant, KS, WY, and CO Summary While most of EPA's previous issues have been resolved, EPA continues to have environmental concerns about the water quality monitoring program. EIS No. 20070378, ERP No. F-VAD- K11116-CA, Fort Rosecrans National Cemetery Annex, Construction and Operation, Located at Marine Corps Air Station (MCAS) Miramar, Point Loma, San Diego County, CA. Summary EPA continues to have environmental concerns about impacts to biological resources and continues to recommend additional compensation for these

49

Santa Monica High School From Santa Monica, Calif. Wins U.S. Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Santa Monica High School From Santa Monica, Calif. Wins U.S. Santa Monica High School From Santa Monica, Calif. Wins U.S. Department of Energy National Science Bowl® Santa Monica High School From Santa Monica, Calif. Wins U.S. Department of Energy National Science Bowl® May 5, 2008 - 11:30am Addthis WASHINGTON, DC - The U.S. Department of Energy (DOE) today announced that Santa Monica High School from Santa Monica, Calif. is the winner of the 2008 DOE National Science Bowl®. Santa Monica High School beat Mira Loma High School from Sacramento, Calif. in the championship match today at the National Building Museum in Washington, DC. Teams representing 67 high schools from across the United States competed in the National Finals. "I congratulate all of the students who competed in this year's U.S. Department of Energy National Science Bowl," U.S. Secretary of Energy

50

Recent News from the National Labs | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

30, 2013 30, 2013 Acting Energy Secretary Poneman (far left) stand with a team of young entrepreneurs from Brigham Young University -- the regional winners of the National Clean Energy Business Plan Competition. | Photo by Ilya Pupko, ILAsoft.net. Celebrating The Next Generation of Energy Entrepreneurs Recognizing innovative, bold-thinking student entrepreneurs who are working to advance clean energy technologies. April 29, 2013 National Science Bowl 2013 Congratulations, 2013 National Science Bowl Winners The team from Sacramento's Mira Loma High School won the 2013 National Science Bowl in dramatic fashion -- pulling ahead as the clock expired in the final round. April 26, 2013 Right now, teams of middle and high school students from across the country are prepping for a weekend of academic competition like no other - the National Science Bowl. Run by the Energy Department since 1991, the National Science Bowl features the winners of regional competitions from across the country.

51

Students from California and Indiana win DOE's 23rd National Science Bowl  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Students from California and Indiana win DOE's 23rd National Students from California and Indiana win DOE's 23rd National Science Bowl Students from California and Indiana win DOE's 23rd National Science Bowl April 29, 2013 - 12:44pm Addthis NEWS MEDIA CONTACT (202) 586-4940 WASHINGTON - Students from Mira Loma High School from Sacramento, Calif. won the 2013 U.S. Department of Energy (DOE) National Science Bowl today in Washington D.C. This year's championship team in the middle school competition is Creekside Middle School from Carmel, Ind. "Congratulations to our new National Science Bowl Champions, as well as to all of the finalists," said Acting Secretary of Energy Secretary Daniel B. Poneman. "They represent America's future in science, technology and engineering. As leaders of the next generation of our

52

Two California Schools Win the 21st U.S. Department of Energy National  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Two California Schools Win the 21st U.S. Department of Energy Two California Schools Win the 21st U.S. Department of Energy National Science Bowl Two California Schools Win the 21st U.S. Department of Energy National Science Bowl May 2, 2011 - 12:00am Addthis WASHINGTON, D.C. - A high school team from Sacramento and a middle school team from San Ramon won the 2011 U.S. Department of Energy (DOE) National Science Bowl today at the National Building Museum in Washington D.C. Mira Loma High School defeated Montgomery Blair High School from Maryland in the high school national championship match by correctly answering a chemistry question. Gale Ranch Middle School defeated Shahala Middle School from Vancouver, Washington in the middle school national championship match. The high school national champion will receive an all-expense-paid trip in

53

North Carolina School of Science and Mathematics from Durham, NC and  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

North Carolina School of Science and Mathematics from Durham, NC North Carolina School of Science and Mathematics from Durham, NC and Albuquerque Academy from Albuquerque, NM Win the U.S. Department of Energy National Science Bowl North Carolina School of Science and Mathematics from Durham, NC and Albuquerque Academy from Albuquerque, NM Win the U.S. Department of Energy National Science Bowl May 3, 2010 - 12:00am Addthis WASHINGTON, D.C. - A high school team from Durham and a middle school team from Albuquerque won the 2010 U.S. Department of Energy (DOE) National Science Bowl today at the National Building Museum in Washington. North Carolina School of Science and Mathematics beat Mira Loma High School from Sacramento CA in the high school national championship match by correctly answering a chemistry question. Albuquerque Academy beat Gale

54

Effects of Radiation on Adaptive Immunity: Contact Hypersensitivity Model  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation on Adaptive Immunity: Contact Hypersensitivity Model Radiation on Adaptive Immunity: Contact Hypersensitivity Model Gregory Nelson Loma Linda University Abstract It has long been appreciated that cells of the immune system are radiosensitive and use apoptosis as the primary mechanism of cell death following injury. The hypervariability of the immunoglobulin superfamily of genes expressed in lymphoid cells also led to the appreciation of the nonhomologous end joining mechanism of DNA repair. Clinically, whole body irradiation is used in treatment of some lymphomas and as an immunosuppressive agent for bone marrow transplants. Inflammation at sites of radiotherapy is a common side effect. Many studies with radiation have addressed the changes in cell populations following radiation exposure and have shown a reproducible pattern of relative sensitivities amongst

55

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

61 - 29870 of 31,917 results. 61 - 29870 of 31,917 results. Article Two California Schools Win the 21st U.S. Department of Energy National Science Bowl Mira Loma High School and Gale Ranch Middle School Take Top Honors Out of 14,000 Students http://energy.gov/articles/two-california-schools-win-21st-us-department-energy-national-science-bowl Article Obama Administration Awards More than $96 Million for State Energy Programs in Ohio, Oregon, Virginia and West Virginia Funding Will Speed Adoption of Efficiency and Renewable Energy Technologies http://energy.gov/articles/obama-administration-awards-more-96-million-state-energy-programs-ohio-oregon-virginia-and Article U.S. Scientific Team Draws on New Data, Multiple Scientific Methodologies to Reach Updated Estimate of Oil Flows from BP's Well

56

Low Dose Ionizing Radiation Modulates Immune Function New Project Overview  

NLE Websites -- All DOE Office Websites (Extended Search)

Modulates Immune Function New Project Overview Modulates Immune Function New Project Overview Gregory Nelson Loma Linda University Abstract The immune system provides the first line of defense for exposures to environmental hazards. Protective immunity mechanisms using innate or adaptive responses are employed to mitigate acute challenges or amplify the readiness of the system to respond to future challenges. Some stimuli lead to amplified inflammatory reactions such as delayed hypersensitivity which is required for immunity to parasites and can also lead to adverse consequences such as contact dermatitis. Radiation exposure has the potential to aggravate hypersensitivity reactions as well as to suppress protective immunity. Ionizing radiation at high doses has long been recognized as highly effective in destroying cells of the immune system,

57

About | U.S. DOE Office of Science (SC)  

NLE Websites -- All DOE Office Websites (Extended Search)

About About National Science Bowl® (NSB) NSB Home About National Science Bowl Contacts Regional Science Bowl Coordinators National Science Bowl FAQ's Alumni Past National Science Bowl Winners Past National Science Bowl Photos National Science Bowl Logos High School Middle School Attending National Event Volunteers 2013 Competition Results News Media WDTS Home Contact Information National Science Bowl® U.S. Department of Energy SC-27/ Forrestal Building 1000 Independence Ave., SW Washington, DC 20585 P: 202-586-6702 E: National.Science.Bowl@science.doe.gov About Print Text Size: A A A RSS Feeds FeedbackShare Page Mira Loma High School, Sacramento, CA Creekside Middle School from Carmel, IN 1st Place Winners in the 2013 National Science Bowl® Launched in 1991, the National Science Bowl (NSB) is a highly competitive

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Low Dose Radiation Research Program: Universities  

NLE Websites -- All DOE Office Websites (Extended Search)

Universities Universities | Duke University | Loma Linda University | Northwestern University | University of Chicago | University of California Davis | Northwestern University University of Chicago University of California Davis Effects of Low Dose Irradiation on NF-κB Signaling Networks and Mitochondria Principal Investigator: Dr. Gayle Woloschak DOE Low Dose Research Program Projects Low dose-low dose rate irradiation leads to long term changes in numbers of mitochondria and mitochondrial genomes - Principal Investigator: Gayle Woloschak, Professor, Department of Radiation Oncology, Northwestern University, Chicago, IL, USA NF-κB-mediated pro-survival network in low dose radiation-induced adaptive protection - Principal Investigator: Jian Jian Li, Professor, Department of Radiation Oncology, University of California Davis, Davis,

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Electric Power Annual 2011  

Gasoline and Diesel Fuel Update (EIA)

Capacity Capacity Conductor Characteristics Data Year Country NERC Region NERC Sub- region Type Operating (kV) Design (kV) Rating (MVa) Month Year From Terminal To Terminal Length (Miles) Type Pole Type Pole Material Size (MCM) Material Bundling Arrange- ment Present Ultimate Company Code Company Name Organizational Type Ownership (Percent) Project Name Level of Certainty Primary Driver 1 Primary Driver 2 2011 US TRE ERCOT AC 300-399 5 2018 DeCordova Benbrook 27 OH 44372 Delivery 100 00TPIT0004 Conceptual Reliability 2011 US TRE ERCOT AC 300-399 5 2018 Loma Alta Substation Rio Hondo Substation 35 OH 2409 BPUB 100 00TPITno07 Conceptual Reliability 2011 US TRE ERCOT AC 121-150 6 2014 Highway 32 Wimberley 4 OH 14626 PEC 100 05TPIT0065 Planned Reliability 2011 US TRE ERCOT AC 121-150 5 2018 Ennis Switch Ennis 6.32 OH 44372 Oncor Electric Delivery 100

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Energy News | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

May 7, 2009 May 7, 2009 Secretary Chu: President's Energy Budget Creates Jobs, Restores America's Scientific Leadership and Puts Nation on the Path to Energy Independence Washington D.C. --- U.S. May 6, 2009 DOE Selects 53 New Projects Focused on Wind Energy for up to $8.5 Million May 6, 2009 Secretaries Chu and Donovan Sign Agreement to Help Working Families Weatherize Their Homes Unprecedented interagency collaboration will help save energy cost, lower carbon footprint May 6, 2009 Secretary Chu Announces Funding for 71 University-Led Nuclear Research and Development Projects WASHINGTON, DC - U.S. May 4, 2009 Mira Loma High School and Hopkins Junior High School from California Win U.S. Department of Energy National Science Bowl WASHINGTON, DC - High school and middle school teams from California won

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61

Nanodosimetry: Principle and Current Status  

Science Conference Proceedings (OSTI)

Due to the success of theoretical track structure Monte Carlo simulations, showing that features of ionization patterns on the nanometer level are important for the biological effectiveness of ionizing radiation, several new methods for experimental track structure investigations have been developed in recent years. These methods all use the principle of density scaling in low-pressure gas to probe track structure in macroscopic dimensions, ideally with single-ionization resolution. The new field of experimental track structure investigation, which has been called nanodosimetry, can be approached in two ways: (1) the number of ionizations in a defined, ideally wall-less, sensitive volume is registered per single primary particle and cluster size distributions are obtained, or (2) the full track structure of an ion track segment is 'imaged'. Existing nanodosimetric methods are based on the first approach, but a track structure imaging detector is currently under development at Loma Linda University. This contribution will review the principle and existing technical approaches to nanodosimetry and will give an outlook on future developments and applications.

Schulte, Reinhard W. [Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354 (United States)

2011-05-05T23:59:59.000Z

62

Independent seismic evaluation of the 24-580-980 south connector ramps response to the south connector ramps to a magnitude 7.25 Hayward Fault earthquake. Volume 3  

SciTech Connect

The 24/580/980 interchange is located near Oakland California on the Eastern perimeter of the San Francisco Bay (Fig. 1 and Fig. 2). This interchange is a major artery in the Eastern San Francisco Bay area and provides a critical link between major bay area highways. The main Concord line of the Bay Area Rapid Transit System (BART), with ridership of approximately 270,000 per day, runs underneath the interchange. The interchange site is approximately 4 Km from the Hayward fault and 16 Km from the San Andreas fault. The reinforced concrete interchange was designed and constructed in the mid 1960`s and thus the asphalt structure has many of the vulnerabilities associated with typical pre-1970`s concrete structures (Roberts [1], Zefinski [2], Chai et. al. [3], Priestly and Seible [4]). In 1980 some of the seismic vulnerabilities were addressed as the interchange was retrofit with deck hinge restrainers as part of the California Department of Transportation (Caltrans) state-wide seismic retrofit of bridge expansion joints. The interchange was subjected to earthquake motion during the 1989 Loma Prieta earthquake and sustained minor damage in some of the concrete diaphragms which support the hinge restrainer forces [5]. Caltrans engineers, working together with their external consultants Imbsen and Associates, have recently completed a seismic retrofit design for portions of the interchange. The retrofit is primarily intended to fix inadequacies in many of the 1960`s vintage reinforced concrete elements which constitute the bridge superstructure and foundations.

McCallen, D.B., Gerhard, M.A., Trummer, D.J., Murray, R.C.

1996-11-01T23:59:59.000Z

63

LBNL Campus Map Final  

NLE Websites -- All DOE Office Websites (Extended Search)

C C A L IF O R N IA G O L D E N B E A R S ⌬⌲⌭ ⌺〈⌭ ⌺⌵ ⌮⌿ Sherman Davis A r d e n Faculty Glade P P H H H H H H P P H S P L L L L O O O O O O O O O O O O O S O S O O L L L L L Mather Redwood Grove Californian North American Meso- American Garden of Old Roses Mediterranean/ European Miocene Sequoia Forest Western Herbs Chinese Herbs Australian Asian New World Desert South American African Palms & Cycads LeRoy Ave La Loma Ave Highland Pl Bancroft Way G a y le y R d S t a d i u m R i m W a y C a n y o n R d M o s s w o o d R d C e n te nn ia l D r C e n t e n n ia l D r C y c l o t r o n R d Un ive rs ity S o u th D r Piedm on t Av e C a l v in R d G la s e r R d M c M il la n R d C h a m b e r l a i n R d A l v a r e z R d 88 65 50A 50 50B 70A 70 54 6 7 17 27 53 52 16 14 4 5 25 45 48 37 80 10 2 29 58 47 51 64 63 60 81 82 55 56 90 71 46 26 76 78 75 75A 75B 69 77 79 77A 31 72 Strawberry Entrance Grizzly Peak Entrance National Center for Electron Microscopy 66 62 73 83 85B 84 Human Genome Laboratory 85 74 Lawrence Berkeley

64

Mechanisms of Low Dose Radiation-induced T helper Cell Function  

SciTech Connect

Exposure to radiation above levels normally encountered on Earth can occur during wartime, accidents such as those at Three Mile Island and Chernobyl, and detonation of dirty bombs by terrorists. Relatively high levels of radiation exposure can also occur in certain occupations (low-level waste sites, nuclear power plants, nuclear medicine facilities, airline industry, and space agencies). Depression or dysfunction of the highly radiosensitive cells of the immune system can lead to serious consequences, including increased risk for infections, cancer, hypersensitivity reactions, poor wound healing, and other pathologies. The focus of this research was on the T helper (Th) subset of lymphocytes that secrete cytokines (proteins), and thus control many actions and interactions of other cell types that make up what is collectively known as the immune system. The Department of Energy (DOE) Low Dose Radiation Program is concerned with mechanisms altered by exposure to high energy photons (x- and gamma-rays), protons and electrons. This study compared, for the first time, the low-dose effects of two of these radiation forms, photons and protons, on the response of Th cells, as well as other cell types with which they communicate. The research provided insights regarding gene expression patterns and capacity to secrete potent immunostimulatory and immunosuppressive cytokines, some of which are implicated in pathophysiological processes. Furthermore, the photon versus proton comparison was important not only to healthy individuals who may be exposed, but also to patients undergoing radiotherapy, since many medical centers in the United States, as well as worldwide, are now building proton accelerators. The overall hypothesis of this study was that whole-body exposure to low-dose photons (gamma-rays) will alter CD4+ Th cell function. We further proposed that exposure to low-dose proton radiation will induce a different pattern of gene and functional changes compared to photons. Over the course of this research, tissues other than spleens were archived and with funding obtained from other sources, including the Department of Radiation Medicine at the Loma Linda University Medical Center, some additional assays were performed. Furthermore, groups of additional mice were included that were pre-exposed to low-dose photons before irradiating with acute photons, protons, and simulated solar particle event (SPE) protons. Hence, the original support together with the additional funding for our research led to generation of much valuable information that was originally not anticipated. Some of the data has already resulted in published articles, manuscripts in review, and a number of presentations at scientific conferences and workshops. Difficulties in reliable and reproducible quantification of secreted cytokines using multi-plex technology delayed completion of this study for a period of time. However, final analyses of the remaining data are currently being performed and should result in additional publications and presentations in the near future. Some of the most notable conclusions, thus far, are briefly summarized below: - Distribution of leukocytes were dependent upon cell type, radiation quality, body compartment analyzed, and time after exposure. Low-dose protons tended to have less effect on numbers of major leukocyte populations and T cell subsets compared to low-dose photons. - The patterns of gene and cytokine expression in CD4+ T cells after protracted low-dose irradiation were significantly modified and highly dependent upon the total dose and time after exposure. - Patterns of gene and cytokine expression differed substantially among groups exposed to low-dose photons versus low-dose protons; differences were also noted among groups exposed to much higher doses of photons, protons, and simulated SPE protons. - Some measurements indicated that exposure to low-dose photon radiation, especially 0.01 Gy, significantly normalized at least some adverse effects of simulated SPE protons, thereby suggesting that this l

Gridley, Daila S.

2008-10-31T23:59:59.000Z

65

Biological & Environmental Research Abstracts Database  

Office of Scientific and Technical Information (OSTI)

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