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Sample records for bssd genomic science

  1. Biological Systems Science Division (BSSD) | U.S. DOE Office of Science

    Office of Science (SC) Website

    (SC) Biological Systems Science Division (BSSD) Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Genomic Science DOE Bioenergy Research Centers Bioimaging Technology DOE Joint Genome Institute Structural Biology Radiochemistry & Imaging Instrumentation Radiobiology: Low Dose Radiation Research DOE Human Subjects Protection Program Climate and Environmental Sciences Division (CESD) Research Abstracts Searchable Archive of BER

  2. Genomic Science | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Genomic Science Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Genomic Science DOE Bioenergy Research Centers Bioimaging Technology DOE Joint Genome Institute Structural Biology Radiochemistry & Imaging Instrumentation Radiobiology: Low Dose Radiation Research DOE Human Subjects Protection Program Climate and Environmental Sciences Division (CESD) Research Abstracts Searchable Archive of BER Highlights External link Facilities

  3. DOE Joint Genome Institute | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    DOE Joint Genome Institute Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Genomic Science DOE Bioenergy Research Centers Bioimaging Technology DOE Joint Genome Institute Structural Biology Radiochemistry & Imaging Instrumentation Radiobiology: Low Dose Radiation Research DOE Human Subjects Protection Program Climate and Environmental Sciences Division (CESD) Research Abstracts Searchable Archive of BER Highlights External link

  4. Structural Biology | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Structural Biology Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Genomic Science DOE Bioenergy Research Centers Bioimaging Technology DOE Joint Genome Institute Structural Biology Radiochemistry & Imaging Instrumentation Radiobiology: Low Dose Radiation Research DOE Human Subjects Protection Program Climate and Environmental Sciences Division (CESD) Research Abstracts Searchable Archive of BER Highlights External link

  5. Genome Science/Technologies

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genome Genome Science/Technologies Los Alamos using cutting-edge sequencing, finishing, and analysis, impact valuable genomic data. Srinivas Iyer Bioscience Group Leader Email Get Expertise David Bruce Bioscience Deputy Group Leader Email Momchilo Vuyisich Scientist Email Rebecca McDonald Bioscience Communications Email State-of-the art technology and extensive genomics expertise Protein research Read caption + Los Alamos National Laboratory graduate student, Patricia Langan, changes the

  6. Genome Science/Technologies

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    intra-genomic species heterogeneity and cell-to-cell interactions. He also loves volleyball, running, eating, sketching, shopping, and chillin' with a good movie. Cheryl...

  7. Terrestrial Ecosystem Science | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Terrestrial Ecosystem Science Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Climate and Environmental Sciences Division (CESD) ARM Climate Research Facility Atmospheric System Research (ASR) Program Data Management Earth System Modeling (ESM) Program William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) Integrated Assessment of Global Climate Change Regional & Global Climate Modeling (RGCM) Program Subsurface

  8. Climate and Environmental Sciences Division (CESD) | U.S. DOE Office of

    Office of Science (SC) Website

    Science (SC) Climate and Environmental Sciences Division (CESD) Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Climate and Environmental Sciences Division (CESD) ARM Climate Research Facility Atmospheric System Research (ASR) Program Data Management Earth System Modeling (ESM) Program William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) Integrated Assessment of Global Climate Change Regional & Global Climate

  9. Genome Science and Personalized Cancer Treatment

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-07

    August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks Ś particularly with regard to breast cancer.

  10. Genome Science and Personalized Cancer Treatment

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-04

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks Ś particularly with regard to breast cancer.

  11. Genome Science and Personalized Cancer Treatment

    ScienceCinema (OSTI)

    Gray, Joe

    2010-01-08

    August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  12. Research | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Research Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Climate and Environmental Sciences Division (CESD) Research Abstracts Searchable Archive of BER Highlights External link Facilities Science Highlights Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) Community Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown

  13. Atmospheric System Research (ASR) Program | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Atmospheric System Research (ASR) Program Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Climate and Environmental Sciences Division (CESD) ARM Climate Research Facility Atmospheric System Research (ASR) Program Data Management Earth System Modeling (ESM) Program William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) Integrated Assessment of Global Climate Change Regional & Global Climate Modeling (RGCM) Program

  14. Earth System Modeling (ESM) Program | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Earth System Modeling (ESM) Program Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Climate and Environmental Sciences Division (CESD) ARM Climate Research Facility Atmospheric System Research (ASR) Program Data Management Earth System Modeling (ESM) Program William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) Integrated Assessment of Global Climate Change Regional & Global Climate Modeling (RGCM) Program

  15. Integrated Assessment of Global Climate Change | U.S. DOE Office of Science

    Office of Science (SC) Website

    (SC) Integrated Assessment of Global Climate Change Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Climate and Environmental Sciences Division (CESD) ARM Climate Research Facility Atmospheric System Research (ASR) Program Data Management Earth System Modeling (ESM) Program William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) Integrated Assessment of Global Climate Change Regional & Global Climate Modeling

  16. Subsurface Biogeochemical Research | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Subsurface Biogeochemical Research Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Climate and Environmental Sciences Division (CESD) ARM Climate Research Facility Atmospheric System Research (ASR) Program Data Management Earth System Modeling (ESM) Program William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) Integrated Assessment of Global Climate Change Regional & Global Climate Modeling (RGCM) Program Subsurface

  17. Genome Science and Personalized Cancer Treatment (LBNL Summer Lecture Series)

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-04

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks Ś particularly with regard to breast cancer.

  18. Genome Science and Personalized Cancer Treatment (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Gray, Joe

    2011-04-28

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  19. DOE Science Showcase - Genomics | OSTI, US Dept of Energy, Office...

    Office of Scientific and Technical Information (OSTI)

    DOE Genomics Research Information on OSTI.gov In the OSTI Collections: Genomics, Dr. William Watson DOE and Human Genome Research, Mary Schorn Human Genome Research: DOE Origins, ...

  20. Incorporating Genomics and Bioinformatics across the Life Sciences Curriculum

    SciTech Connect (OSTI)

    Ditty, Jayna L.; Kvaal, Christopher A.; Goodner, Brad; Freyermuth, Sharyn K.; Bailey, Cheryl; Britton, Robert A.; Gordon, Stuart G.; Heinhorst, Sabine; Reed, Kelynne; Xu, Zhaohui; Sanders-Lorenz, Erin R.; Axen, Seth; Kim, Edwin; Johns, Mitrick; Scott, Kathleen; Kerfeld, Cheryl A.

    2011-08-01

    Undergraduate life sciences education needs an overhaul, as clearly described in the National Research Council of the National Academies publication BIO 2010: Transforming Undergraduate Education for Future Research Biologists. Among BIO 2010's top recommendations is the need to involve students in working with real data and tools that reflect the nature of life sciences research in the 21st century. Education research studies support the importance of utilizing primary literature, designing and implementing experiments, and analyzing results in the context of a bona fide scientific question in cultivating the analytical skills necessary to become a scientist. Incorporating these basic scientific methodologies in undergraduate education leads to increased undergraduate and post-graduate retention in the sciences. Toward this end, many undergraduate teaching organizations offer training and suggestions for faculty to update and improve their teaching approaches to help students learn as scientists, through design and discovery (e.g., Council of Undergraduate Research [www.cur.org] and Project Kaleidoscope [www.pkal.org]). With the advent of genome sequencing and bioinformatics, many scientists now formulate biological questions and interpret research results in the context of genomic information. Just as the use of bioinformatic tools and databases changed the way scientists investigate problems, it must change how scientists teach to create new opportunities for students to gain experiences reflecting the influence of genomics, proteomics, and bioinformatics on modern life sciences research. Educators have responded by incorporating bioinformatics into diverse life science curricula. While these published exercises in, and guidelines for, bioinformatics curricula are helpful and inspirational, faculty new to the area of bioinformatics inevitably need training in the theoretical underpinnings of the algorithms. Moreover, effectively integrating bioinformatics into courses or independent research projects requires infrastructure for organizing and assessing student work. Here, we present a new platform for faculty to keep current with the rapidly changing field of bioinformatics, the Integrated Microbial Genomes Annotation Collaboration Toolkit (IMG-ACT). It was developed by instructors from both research-intensive and predominately undergraduate institutions in collaboration with the Department of Energy-Joint Genome Institute (DOE-JGI) as a means to innovate and update undergraduate education and faculty development. The IMG-ACT program provides a cadre of tools, including access to a clearinghouse of genome sequences, bioinformatics databases, data storage, instructor course management, and student notebooks for organizing the results of their bioinformatic investigations. In the process, IMG-ACT makes it feasible to provide undergraduate research opportunities to a greater number and diversity of students, in contrast to the traditional mentor-to-student apprenticeship model for undergraduate research, which can be too expensive and time-consuming to provide for every undergraduate. The IMG-ACT serves as the hub for the network of faculty and students that use the system for microbial genome analysis. Open access of the IMG-ACT infrastructure to participating schools ensures that all types of higher education institutions can utilize it. With the infrastructure in place, faculty can focus their efforts on the pedagogy of bioinformatics, involvement of students in research, and use of this tool for their own research agenda. What the original faculty members of the IMG-ACT development team present here is an overview of how the IMG-ACT program has affected our development in terms of teaching and research with the hopes that it will inspire more faculty to get involved.

  1. *** CANCELED *** SCIENCE ON SATURDAY- "Finding a Needle in A (Genomic)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Haystack or How Can Computers Help Cure Cancer" | Princeton Plasma Physics Lab February 9, 2013, 9:30am Science On Saturday MBG Auditorium *** CANCELED *** SCIENCE ON SATURDAY- "Finding a Needle in A (Genomic) Haystack or How Can Computers Help Cure Cancer" Professor Olga G. Troyanskaya Lewis-Sigler Institute for Integrative Genomics & Department of Computer Science, Princeton University Science on Saturday is a series of lectures given by scientists, mathematicians, and

  2. Joint Genome Institute (JGI) | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Joint Genome Institute (JGI) Biological and Environmental Research (BER) BER Home About Research Facilities User Facilities Atmospheric Radiation Measurement Climate Research Facility (ARM) Environmental Molecular Sciences Laboratory (EMSL) Joint Genome Institute (JGI) Science Highlights Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) Community Resources Contact Information Biological and Environmental Research U.S. Department of Energy

  3. Fungal Genomics Program Grigoriev, Igor 59 BASIC BIOLOGICAL SCIENCES...

    Office of Scientific and Technical Information (OSTI)

    and the environment, and to promote functional studies on a system level. Combining new sequencing technologies and comparative genomics tools, JGI is now leading the world...

  4. Large-Scale Sequencing: The Future of Genomic Sciences Colloquium

    SciTech Connect (OSTI)

    Margaret Riley; Merry Buckley

    2009-01-01

    Genetic sequencing and the various molecular techniques it has enabled have revolutionized the field of microbiology. Examining and comparing the genetic sequences borne by microbes - including bacteria, archaea, viruses, and microbial eukaryotes - provides researchers insights into the processes microbes carry out, their pathogenic traits, and new ways to use microorganisms in medicine and manufacturing. Until recently, sequencing entire microbial genomes has been laborious and expensive, and the decision to sequence the genome of an organism was made on a case-by-case basis by individual researchers and funding agencies. Now, thanks to new technologies, the cost and effort of sequencing is within reach for even the smallest facilities, and the ability to sequence the genomes of a significant fraction of microbial life may be possible. The availability of numerous microbial genomes will enable unprecedented insights into microbial evolution, function, and physiology. However, the current ad hoc approach to gathering sequence data has resulted in an unbalanced and highly biased sampling of microbial diversity. A well-coordinated, large-scale effort to target the breadth and depth of microbial diversity would result in the greatest impact. The American Academy of Microbiology convened a colloquium to discuss the scientific benefits of engaging in a large-scale, taxonomically-based sequencing project. A group of individuals with expertise in microbiology, genomics, informatics, ecology, and evolution deliberated on the issues inherent in such an effort and generated a set of specific recommendations for how best to proceed. The vast majority of microbes are presently uncultured and, thus, pose significant challenges to such a taxonomically-based approach to sampling genome diversity. However, we have yet to even scratch the surface of the genomic diversity among cultured microbes. A coordinated sequencing effort of cultured organisms is an appropriate place to begin, since not only are their genomes available, but they are also accompanied by data on environment and physiology that can be used to understand the resulting data. As single cell isolation methods improve, there should be a shift toward incorporating uncultured organisms and communities into this effort. Efforts to sequence cultivated isolates should target characterized isolates from culture collections for which biochemical data are available, as well as other cultures of lasting value from personal collections. The genomes of type strains should be among the first targets for sequencing, but creative culture methods, novel cell isolation, and sorting methods would all be helpful in obtaining organisms we have not yet been able to cultivate for sequencing. The data that should be provided for strains targeted for sequencing will depend on the phylogenetic context of the organism and the amount of information available about its nearest relatives. Annotation is an important part of transforming genome sequences into useful resources, but it represents the most significant bottleneck to the field of comparative genomics right now and must be addressed. Furthermore, there is a need for more consistency in both annotation and achieving annotation data. As new annotation tools become available over time, re-annotation of genomes should be implemented, taking advantage of advancements in annotation techniques in order to capitalize on the genome sequences and increase both the societal and scientific benefit of genomics work. Given the proper resources, the knowledge and ability exist to be able to select model systems, some simple, some less so, and dissect them so that we may understand the processes and interactions at work in them. Colloquium participants suggest a five-pronged, coordinated initiative to exhaustively describe six different microbial ecosystems, designed to describe all the gene diversity, across genomes. In this effort, sequencing should be complemented by other experimental data, particularly transcriptomics and metabolomics data, all of which

  5. Los Alamos Science: The Human Genome Project. Number 20, 1992

    SciTech Connect (OSTI)

    Cooper, N G; Shea, N

    1992-01-01

    This article provides a broad overview of the Human Genome Project, with particular emphasis on work being done at Los Alamos. It tries to emphasize the scientific aspects of the project, compared to the more speculative information presented in the popular press. There is a brief introduction to modern genetics, including a review of classic work. There is a broad overview of the Genome Project, describing what the project is, what are some of its major five-year goals, what are major technological challenges ahead of the project, and what can the field of biology, as well as society expect to see as benefits from this project. Specific results on the efforts directed at mapping chromosomes 16 and 5 are discussed. A brief introduction to DNA libraries is presented, bearing in mind that Los Alamos has housed such libraries for many years prior to the Genome Project. Information on efforts to do applied computational work related to the project are discussed, as well as experimental efforts to do rapid DNA sequencing by means of single-molecule detection using applied spectroscopic methods. The article introduces the Los Alamos staff which are working on the Genome Project, and concludes with brief discussions on ethical, legal, and social implications of this work; a brief glimpse of genetics as it may be practiced in the next century; and a glossary of relevant terms.

  6. Los Alamos Science: The Human Genome Project. Number 20, 1992

    DOE R&D Accomplishments [OSTI]

    Cooper, N. G.; Shea, N. eds.

    1992-01-01

    This document provides a broad overview of the Human Genome Project, with particular emphasis on work being done at Los Alamos. It tries to emphasize the scientific aspects of the project, compared to the more speculative information presented in the popular press. There is a brief introduction to modern genetics, including a review of classic work. There is a broad overview of the Genome Project, describing what the project is, what are some of its major five-year goals, what are major technological challenges ahead of the project, and what can the field of biology, as well as society expect to see as benefits from this project. Specific results on the efforts directed at mapping chromosomes 16 and 5 are discussed. A brief introduction to DNA libraries is presented, bearing in mind that Los Alamos has housed such libraries for many years prior to the Genome Project. Information on efforts to do applied computational work related to the project are discussed, as well as experimental efforts to do rapid DNA sequencing by means of single-molecule detection using applied spectroscopic methods. The article introduces the Los Alamos staff which are working on the Genome Project, and concludes with brief discussions on ethical, legal, and social implications of this work; a brief glimpse of genetics as it may be practiced in the next century; and a glossary of relevant terms.

  7. Applications of Genome-based Science in Shaping Citrus Industries of the World (JGI Seventh Annual User Meeting, 2012: Genomics of Energy and Environment)

    SciTech Connect (OSTI)

    Gmitter Jr, Fred [University of Florida

    2012-03-21

    Fred Gmitter from the University of Florida on "Applications of Genome-based Science in Shaping the Future of the World's Citrus Industries" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, California.

  8. Applications of Genome-based Science in Shaping Citrus Industries of the World (JGI Seventh Annual User Meeting, 2012: Genomics of Energy and Environment)

    ScienceCinema (OSTI)

    Gmitter Jr, Fred [University of Florida

    2013-01-15

    Fred Gmitter from the University of Florida on "Applications of Genome-based Science in Shaping the Future of the World's Citrus Industries" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, California.

  9. Assembling Complex Plant Genomes | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Assembling Complex Plant Genomes Biological and Environmental Research (BER) BER Home About Research Facilities Science Highlights Searchable Archive of BER Highlights External link Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) Community Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3251 F: (301) 903-5051

  10. Genome Databases Get Faster, Bigger, Stronger | U.S. DOE Office of Science

    Office of Science (SC) Website

    (SC) Genome Databases Get Faster, Bigger, Stronger Biological and Environmental Research (BER) BER Home About Research Facilities Science Highlights Searchable Archive of BER Highlights External link Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) Community Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301)

  11. LLNL's Big Science Capabilities Help Spur Over $796 Billion in U.S. Economic Activity Sequencing the Human Genome

    SciTech Connect (OSTI)

    Stewart, Jeffrey S.

    2015-07-28

    LLNLĺs successful history of taking on big science projects spans beyond national security and has helped create billions of dollars per year in new economic activity. One example is LLNLĺs role in helping sequence the human genome. Over $796 billion in new economic activity in over half a dozen fields has been documented since LLNL successfully completed this Grand Challenge.

  12. Standards in Genomic Science: An Open-Access Journal of the Genomic Standards Consortium (GSC8 Meeting)

    ScienceCinema (OSTI)

    Garrity, George

    2011-06-03

    George Garrity of Michigan State University talks about the GSC's open-access journal SIGS at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 9, 2009.

  13. Genome To Life Report | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Genome To Life Report Biological and Environmental Research Advisory Committee (BERAC) BERAC Home Meetings Members Charges/Reports Current BERAC Charges Archive of BERAC Reports Charter .pdf file (135KB) BER Committees of Visitors Federal Advisory Committees BER Home Charges/Reports Genome To Life Report Print Text Size: A A A FeedbackShare Page DOE Genomes to Life Program Information External link BRINGING THE GENOME TO LIFE - Energy Related Biology in the New Genomic World - A New Research

  14. DOE Joint Genome Institute: A DOE Office of Science User Facility...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Institute About Us Phone Book Contact Us Search Our Science Our DOE Mission Areas DOE Bioenergy Research Centers Science Programs Science Highlights Scientists at JGI Our Projects...

  15. Genome

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Decoding dark matter in genes February 19, 2016 Decoding the Dark Matter of the Human Genome Both animal and human studies have shown that traits acquired by the parents, such as stress responses or the ability to store fat, can be passed on to their offspring. While DNA remains unaltered, what triggers these changes in phenotype is the activation or deactivation of genes--in other words, whether certain genes produce the proteins they code for...Possible future applications, for example,

  16. Genomic Advances to Improve Biomass for Biofuels (LBNL Science at the Theater)

    ScienceCinema (OSTI)

    Rokhsar, Daniel

    2011-04-28

    Lawrence Berkeley National Lab bioscientist Daniel Rokhsar discusses genomic advances to improve biomass for biofuels. He presented his talk Feb. 11, 2008 in Berkeley, California as part of Berkeley Lab's community lecture series. Rokhsar works with the U.S. Department of Energy's Joint Genome Institute and Berkeley Lab's Genomics Division.

  17. Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Office of Science Office of Science * * * Office of Science Office of * * * * * Office of Science Office of Science * * * Office of Science * * * * 287 115...

  18. Whitehead Policy Symposium. The Human Genome Project: Science, law, and social change in the 21st century

    SciTech Connect (OSTI)

    Nichols, E.K.

    2000-02-17

    Advances in the biomedical sciences, especially in human genomics, will dramatically influence law, medicine, public health, and many other sectors of our society in the decades ahead. The public already senses the revolutionary nature of genomic knowledge. In the US and Europe, we have seen widespread discussions about genetic discrimination in health insurance; privacy issues raised by the proliferation of DNA data banks; the challenge of interpreting new DNA diagnostic tests; changing definitions of what it means to be healthy; and the science and ethics of cloning animals and human beings. The primary goal of the Whitehead/ASLME Policy Symposium was to provide a bridge between the research community and professionals, who were just beginning to grasp the potential impact of new genetic technologies on their fields. The ''Human Genome Project: Science, Law, and Social Change in the 21st Century'' initially was designed as a forum for 300-500 physicians, lawyers, consumers, ethicists, and scientists to explore the impact of new genetic technologies and prepare for the challenges ahead.

  19. Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Stockpile Stewardship National Security National Competitiveness Fusion and Ignition Energy for the Future How to Make a Star Discovery Science Photon Science HAPLS

  20. Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and researchers at work. News Releases Science Briefs Photos Picture of the Week Social Media Videos Fact Sheets Publications PHOTOS BY TOPIC Careers Community Visitors...

  1. science

    National Nuclear Security Administration (NNSA)

    through the Predictive Capability Framework (PCF). The PCF is a long-term integrated roadmap to guide the science, technology and engineering activities and Directed Stockpile...

  2. Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    U.S. Department of energy atmospheric radiation measurement program ARM ARM The ... of Science created the Atmospheric Radiation Measurement (ARM) Program within the ...

  3. Genomics and Systems Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genomics and Systems Biology Genomics and Systems Biology Los Alamos scientists perform research in functional genomics and structural genomics, and applications for such work cover diverse fields such as energy, agriculture, and environmental cleanup. Contact Us Babetta Marrone Biofuels Program Manager Email Cheryl Kuske DOE BER Biological System Science Division Program Manager Email Kirsten McCabe Emerging Threats Program Manager Email Rebecca McDonald Bioscience Communications Email "We

  4. National Laboratory] Basic Biological Sciences(59) Biological...

    Office of Scientific and Technical Information (OSTI)

    Achievements of structural genomics Terwilliger, Thomas C. Los Alamos National Laboratory Basic Biological Sciences(59) Biological Science Biological Science Abstract Not...

  5. Rapid genome resequencing of an atoxigenic strain of Aspergillus

    Office of Scientific and Technical Information (OSTI)

    de Barcelona, Bellaterra, Catalonia (Spain) 59 BASIC BIOLOGICAL SCIENCES fungal genomics; gene regulatory networks fungal genomics; gene regulatory networks In...

  6. Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Wikipedia to forecast diseases November 13, 2014 Los Alamos research published in Public Library of Science LOS ALAMOS, N.M., Nov. 13, 2014-Scientists can now monitor and forecast diseases around the globe more effectively by analyzing views of Wikipedia articles, according to a team from Los Alamos National Laboratory. "A global disease-forecasting system will improve the way we respond to epidemics," scientist Sara Del Valle said. "In the same way we check the weather each

  7. Joint Genome Institute's Automation Approach and History

    SciTech Connect (OSTI)

    Roberts, Simon

    2006-07-05

    Department of Energy/Joint Genome Institute (DOE/JGI) collaborates with DOE national laboratories and community users, to advance genome science in support of the DOE missions of clean bio-energy, carbon cycling, and bioremediation.

  8. Science Highlights | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    BER User Facilities Environmental Molecular Sciences Laboratory (EMSL) Atmospheric Radiation Measurement Climate Research Facility (ARM) Joint Genome Institute (JGI) FES User ...

  9. Science Highlights | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    ... BER User Facilities Environmental Molecular Sciences Laboratory (EMSL) Atmospheric Radiation Measurement Climate Research Facility (ARM) Joint Genome Institute (JGI) FES User ...

  10. Genomic definition of species

    SciTech Connect (OSTI)

    Crkvenjakov, R.; Drmanac, R.

    1991-07-01

    The subject of this paper is the definition of species based on the assumption that genome is the fundamental level for the origin and maintenance of biological diversity. For this view to be logically consistent it is necessary to assume the existence and operation of the new law which we call genome law. For this reason the genome law is included in the explanation of species phenomenon presented here even if its precise formulation and elaboration are left for the future. The intellectual underpinnings of this definition can be traced to Goldschmidt. We wish to explore some philosophical aspects of the definition of species in terms of the genome. The point of proposing the definition on these grounds is that any real advance in evolutionary theory has to be correct in both its philosophy and its science.

  11. Biological Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Energy Science Engineering Science Environmental Science Fusion Science Math & Computer Science Nuclear Science Share Your Research NERSC Citations Home Science at...

  12. Genomic Aspects of Research Involving Polyploid Plants

    SciTech Connect (OSTI)

    Yang, Xiaohan [ORNL; Ye, Chuyu [ORNL; Tschaplinski, Timothy J [ORNL; Wullschleger, Stan D [ORNL; Tuskan, Gerald A [ORNL

    2011-01-01

    Almost all extant plant species have spontaneously doubled their genomes at least once in their evolutionary histories, resulting in polyploidy which provided a rich genomic resource for evolutionary processes. Moreover, superior polyploid clones have been created during the process of crop domestication. Polyploid plants generated by evolutionary processes and/or crop domestication have been the intentional or serendipitous focus of research dealing with the dynamics and consequences of genome evolution. One of the new trends in genomics research is to create synthetic polyploid plants which provide materials for studying the initial genomic changes/responses immediately after polyploid formation. Polyploid plants are also used in functional genomics research to study gene expression in a complex genomic background. In this review, we summarize the recent progress in genomics research involving ancient, young, and synthetic polyploid plants, with a focus on genome size evolution, genomics diversity, genomic rearrangement, genetic and epigenetic changes in duplicated genes, gene discovery, and comparative genomics. Implications on plant sciences including evolution, functional genomics, and plant breeding are presented. It is anticipated that polyploids will be a regular subject of genomics research in the foreseeable future as the rapid advances in DNA sequencing technology create unprecedented opportunities for discovering and monitoring genomic and transcriptomic changes in polyploid plants. The fast accumulation of knowledge on polyploid formation, maintenance, and divergence at whole-genome and subgenome levels will not only help plant biologists understand how plants have evolved and diversified, but also assist plant breeders in designing new strategies for crop improvement.

  13. Human Genome Program Image Gallery (from genomics.energy.gov)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    This collection contains approximately 240 images from the genome programs of DOE's Office of Science. The images are divided into galleries related to biofuels research, systems biology, and basic genomics. Each image has a title, a basic citation, and a credit or source. Most of the images are original graphics created by the Genome Management Information System (GMIS). GMIS images are recognizable by their credit line. Permission to use these graphics is not needed, but please credit the U.S. Department of Energy Genome Programs and provide the website http://genomics.energy.gov. Other images were provided by third parties and not created by the U.S. Department of Energy. Users must contact the person listed in the credit line before using those images. The high-resolution images can be downloaded.

  14. INTEGRATED GENOME-BASED STUDIES OF SHEWANELLA ECOPHYSIOLOGY TIEDJE...

    Office of Scientific and Technical Information (OSTI)

    BIOLOGICAL SCIENCES The aim of the work reported is to study Shewanella population genomics, and to understand the evolution, ecophysiology, and speciation of Shewanella. The...

  15. Rapid genome resequencing of an atoxigenic strain of Aspergillus...

    Office of Scientific and Technical Information (OSTI)

    United States Language: English Subject: 59 BASIC BIOLOGICAL SCIENCES fungal genomics; gene regulatory networks Word Cloud More Like This Free Publicly Accessible Full...

  16. Energy Department Awards $92 Million for Genomics Research |...

    Office of Science (SC) Website

    Energy Department Awards 92 Million for Genomics Research News News Home Featured ... Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW ...

  17. Genome Engineering

    SciTech Connect (OSTI)

    Voytas, Dan [University of Minnesota

    2014-03-20

    Dan Voytas, University of Minnesota, at the 9th Annual Genomics of Energy & Environment Meeting on March 20, 2014 in Walnut Creek, Calif

  18. Genome Analyses and Supplement Data from the International Populus Genome Consortium (IPGC)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    International Populus Genome Consortium (IPGC)

    The sequencing of the first tree genome, that of Populus, was a project initiated by the Office of Biological and Environmental Research in DOEÔÇÖs Office of Science. The International Populus Genome Consortium (IPGC) was formed to help develop and guide post-sequence activities. The IPGC website, hosted at the Oak Ridge National Laboratory, provides draft sequence data as it is made available from DOE Joint Genome Institute, genome analyses for Populus, lists of related publications and resources, and the science plan. The data are available at http://www.ornl.gov/sci/ipgc/ssr_resource.htm.

  19. Genome Analyses and Supplement Data from the International Populus Genome Consortium (IPGC)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    International Populus Genome Consortium (IPGC)

    The sequencing of the first tree genome, that of Populus, was a project initiated by the Office of Biological and Environmental Research in DOEĺs Office of Science. The International Populus Genome Consortium (IPGC) was formed to help develop and guide post-sequence activities. The IPGC website, hosted at the Oak Ridge National Laboratory, provides draft sequence data as it is made available from DOE Joint Genome Institute, genome analyses for Populus, lists of related publications and resources, and the science plan. The data are available at http://www.ornl.gov/sci/ipgc/ssr_resource.htm.

  20. Stories of Discovery & Innovation: From Human Genome to Materials "Genome"

    Office of Science (SC) Website

    | U.S. DOE Office of Science (SC) From Human Genome to Materials "Genome" Energy Frontier Research Centers (EFRCs) EFRCs Home Centers Research Science Highlights News & Events EFRC News EFRC Events DOE Announcements Publications History Contact BES Home 07.09.14 Stories of Discovery & Innovation: From Human Genome to Materials "Genome" Print Text Size: A A A Subscribe FeedbackShare Page Government initiative seeks to speed the pace of materials discovery and

  1. Applications of Nuclear Science | U.S. DOE Office of Science...

    Office of Science (SC) Website

    BER User Facilities Environmental Molecular Sciences Laboratory (EMSL) Atmospheric Radiation Measurement Climate Research Facility (ARM) Joint Genome Institute (JGI) FES User ...

  2. Life sciences and environmental sciences

    SciTech Connect (OSTI)

    Not Available

    1992-02-01

    The DOE laboratories play a unique role in bringing multidisciplinary talents -- in biology, physics, chemistry, computer sciences, and engineering -- to bear on major problems in the life and environmental sciences. Specifically, the laboratories utilize these talents to fulfill OHER's mission of exploring and mitigating the health and environmental effects of energy use, and of developing health and medical applications of nuclear energy-related phenomena. At Lawrence Berkeley Laboratory (LBL) support of this mission is evident across the spectrum of OHER-sponsored research, especially in the broad areas of genomics, structural biology, basic cell and molecular biology, carcinogenesis, energy and environment, applications to biotechnology, and molecular, nuclear and radiation medicine. These research areas are briefly described.

  3. Life sciences and environmental sciences

    SciTech Connect (OSTI)

    Not Available

    1992-02-01

    The DOE laboratories play a unique role in bringing multidisciplinary talents -- in biology, physics, chemistry, computer sciences, and engineering -- to bear on major problems in the life and environmental sciences. Specifically, the laboratories utilize these talents to fulfill OHER`s mission of exploring and mitigating the health and environmental effects of energy use, and of developing health and medical applications of nuclear energy-related phenomena. At Lawrence Berkeley Laboratory (LBL) support of this mission is evident across the spectrum of OHER-sponsored research, especially in the broad areas of genomics, structural biology, basic cell and molecular biology, carcinogenesis, energy and environment, applications to biotechnology, and molecular, nuclear and radiation medicine. These research areas are briefly described.

  4. Fueling the Future with Fungal Genomes

    SciTech Connect (OSTI)

    Grigoriev, Igor V.

    2014-10-27

    Genomes of fungi relevant to energy and environment are in focus of the JGI Fungal Genomic Program. One of its projects, the Genomics Encyclopedia of Fungi, targets fungi related to plant health (symbionts and pathogens) and biorefinery processes (cellulose degradation and sugar fermentation) by means of genome sequencing and analysis. New chapters of the Encyclopedia can be opened with user proposals to the JGI Community Science Program (CSP). Another JGI project, the 1000 fungal genomes, explores fungal diversity on genome level at scale and is open for users to nominate new species for sequencing. Over 400 fungal genomes have been sequenced by JGI to date and released through MycoCosm (www.jgi.doe.gov/fungi), a fungal web-portal, which integrates sequence and functional data with genome analysis tools for user community. Sequence analysis supported by functional genomics will lead to developing parts list for complex systems ranging from ecosystems of biofuel crops to biorefineries. Recent examples of such ÔÇśpartsÔÇÖ suggested by comparative genomics and functional analysis in these areas are presented here.

  5. January 23, 2016: Science on Saturday: Using Physics and Chemistry...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    23, 2016 - 09:30 January 23, 2016: Science on Saturday: Using Physics and Chemistry to Understand the Genome PPPL, MBG Auditorium Speaker: Professor Mary Jo Ondrechen Northeastern...

  6. 2012 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    BER User Facilities Environmental Molecular Sciences Laboratory (EMSL) Atmospheric Radiation Measurement Climate Research Facility (ARM) Joint Genome Institute (JGI) FES User ...

  7. 2011 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    BER User Facilities Environmental Molecular Sciences Laboratory (EMSL) Atmospheric Radiation Measurement Climate Research Facility (ARM) Joint Genome Institute (JGI) FES User ...

  8. 2014 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    BER User Facilities Environmental Molecular Sciences Laboratory (EMSL) Atmospheric Radiation Measurement Climate Research Facility (ARM) Joint Genome Institute (JGI) FES User ...

  9. 2016 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    BER User Facilities Environmental Molecular Sciences Laboratory (EMSL) Atmospheric Radiation Measurement Climate Research Facility (ARM) Joint Genome Institute (JGI) FES User ...

  10. 2015 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    BER User Facilities Environmental Molecular Sciences Laboratory (EMSL) Atmospheric Radiation Measurement Climate Research Facility (ARM) Joint Genome Institute (JGI) FES User ...

  11. 2013 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    BER User Facilities Environmental Molecular Sciences Laboratory (EMSL) Atmospheric Radiation Measurement Climate Research Facility (ARM) Joint Genome Institute (JGI) FES User ...

  12. Science and Science Fiction

    ScienceCinema (OSTI)

    Scherrer, Robert [Vanderbilt University, Nashville, Tennessee, United States

    2009-09-01

    I will explore the similarities and differences between the process of writing science fiction and the process of 'producing' science, specifically theoretical physics. What are the ground rules for introducing unproven new ideas in science fiction, and how do they differ from the corresponding rules in physics? How predictive is science fiction? (For that matter, how predictive is theoretical physics?) I will also contrast the way in which information is presented in science fiction, as opposed to its presentation in scientific papers, and I will examine the relative importance of ideas (as opposed to the importance of the way in which these ideas are presented). Finally, I will discuss whether a background as a research scientist provides any advantage in writing science fiction.

  13. Science Briefs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Briefs /newsroom/_assets/images/newsroom-icon.jpg Science Briefs Read in detail about specific Los Alamos science achievements, and the honors our scientists are accruing. Science Briefs - 2016┬╗ Science Briefs - 2015┬╗ Science Briefs - 2014┬╗ Science Briefs - 2013┬╗ Science Briefs - 2012┬╗ Science Briefs - 2011┬╗ Shown are time lapse images of supercritical CO2 displacing water in a fracture etched into a shale micromodel. The white, blue and gray colors represent supercritical CO2,

  14. Science Briefs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Briefs newsroomassetsimageslegacy-icon-short.jpg Science Briefs Read in detail about specific Los Alamos science achievements, and the honors our scientists are...

  15. Researchers Funded by the DOE "Genomes to Life" Program Achieve...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    in stitching together a genome of a phage, or a virus of bacteria. An article by Dr. ... the National Institutes of Health and the Department of Energy's Office of Science. ...

  16. MycoCosm, an Integrated Fungal Genomics Resource Shabalov, Igor...

    Office of Scientific and Technical Information (OSTI)

    Resource Shabalov, Igor; Grigoriev, Igor 59 BASIC BIOLOGICAL SCIENCES MycoCosm is a web-based interactive fungal genomics resource, which was first released in March 2010, in...

  17. Institute for Materials Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Materials Science Institute for Materials Science x

  18. *** CANCELLED *** Using Physics to Understand the Genome | Princeton Plasma

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Lab 4, 2015, 9:30am to 11:00am Science On Saturday MBG Auditorium *** CANCELLED *** Using Physics to Understand the Genome Professor Mary Jo Ondrechen, Department of Chemistry and Chemical Biology Northeastern University Abstract: PDF icon Ondrechen.pdf Sorry, Science On Saturday fans: lecture cancelled due to inclement weather. Contact Information Website: Science on Saturday Coordinator(s): Deedee Ortiz-Arias, Science Education Department Program Administraor dortiz@pppl.gov

  19. Building international genomics collaboration for global health security

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cui, Helen H.; Erkkila, Tracy; Chain, Patrick S. G.; Vuyisich, Momchilo

    2015-12-07

    Genome science and technologies are transforming life sciences globally in many ways and becoming a highly desirable area for international collaboration to strengthen global health. The Genome Science Program at the Los Alamos National Laboratory is leveraging a long history of expertise in genomics research to assist multiple partner nations in advancing their genomics and bioinformatics capabilities. The capability development objectives focus on providing a molecular genomics-based scientific approach for pathogen detection, characterization, and biosurveillance applications. The general approaches include introduction of basic principles in genomics technologies, training on laboratory methodologies and bioinformatic analysis of resulting data, procurement, and installationmore┬á┬╗ of next-generation sequencing instruments, establishing bioinformatics software capabilities, and exploring collaborative applications of the genomics capabilities in public health. Genome centers have been established with public health and research institutions in the Republic of Georgia, Kingdom of Jordan, Uganda, and Gabon; broader collaborations in genomics applications have also been developed with research institutions in many other countries.┬ź┬áless

  20. Science Events

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Science Events Learn about our science by coming to Frontiers in Science lectures, catch Cafe Scientific events in your community, or come to sicence events at the Bradbury...

  1. Materials Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Materials Science /science-innovation/_assets/images/icon-science.jpg Materials Science National security depends on science and technology. The United States relies on Los Alamos National Laboratory for the best of both. No place on Earth pursues a broader array of world-class scientific endeavors. Materials Physics and Applications┬╗ Materials Science and Technology┬╗ Institute for Materials Science┬╗ Materials Science Rob Dickerson uses a state-of-the-art transmission electron microscope at

  2. A GSC Global Genome Census (GSC8 Meeting)

    ScienceCinema (OSTI)

    Kyrpides, Nikos [DOE JGI

    2011-04-29

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Nikos Kyrpides of the DOE Joint Genome Institute discusses the notion of a global genome census at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 9, 2009.

  3. ARM - Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    govScience Science Research Themes Research Highlights Journal Articles Collaborations Atmospheric System Research (ASR) Earth System Modeling Regional & Global Climate Modeling Terrestrial Ecosystem Science Performance Metrics User Meetings Past ARM Science Team Meetings ASR Meetings Accomplishments Accomplishments in Atmospheric Science, 2008-2013 (PDF, 7.4MB) ARM Accomplishments from the Science Program and User Facility, 1989-2008 (PDF, 696KB) Science New C-band scanning ARM

  4. Genomic Sequence Comparisons, 1987-2003 Final Report

    SciTech Connect (OSTI)

    George M. Church

    2004-07-29

    This project was to develop new DNA sequencing and RNA and protein quantitation methods and related genome annotation tools. The project began in 1987 with the development of multiplex sequencing (published in Science in 1988), and one of the first automated sequencing methods. This lead to the first commercial genome sequence in 1994 and to the establishment of the main commercial participants (GTC then Agencourt) in the public DOE/NIH genome project. In collaboration with GTC we contributed to one of the first complete DOE genome sequences, in 1997, that of Methanobacterium thermoautotropicum, a species of great relevance to energy-rich gas production.

  5. Defining Genome Project Standards in a New Era of Sequencing (GSC8 Meeting)

    ScienceCinema (OSTI)

    Chain, Patrick [DOE JGI

    2011-04-28

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego.

  6. Detection Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chemistry for Measurement and Detection Science Chemistry for Measurement and Detection Science Project Description Chemistry used in measurement and detection science plays a crucial role in the Laboratory's Science of Signatures scientific thrust. Measurement and detection science areas that require chemistry include nuclear and radiological, materials, biological, energy, climate, and space. Los Alamos scientists integrate chemical-science capabilities to ensure that the Laboratory can

  7. Chemical Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chemical Science /science-innovation/_assets/images/icon-science.jpg Chemical Science National security depends on science and technology. The United States relies on Los Alamos National Laboratory for the best of both. No place on Earth pursues a broader array of world-class scientific endeavors. Actinide Chemistry┬╗ Modeling & Simulation┬╗ Synthetic and Mechanistic Chemistry┬╗ Chemistry for Measurement and Detection Science┬╗ Chemical Researcher Jeff Pietryga shows two vials of

  8. Science Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Highlights Science Highlights Print Science Highlights Featured scientific research based on publications resulting from work done at the ALS. Highlights are nominated by management and beamline scientists for their scientific significance. Current highlights (2004-present), highlight archives (1995-2004), and Summary Slides of ALS Science Highlights are also available. Science Briefs Short reports on recent research submitted by ALS beamline scientists and users. Science Caf├ęs Informal

  9. Nuclear Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nuclear Science Nuclear Science Experimental and theoretical nuclear research carried out at NERSC is driven by the quest for improving our understanding of the building blocks of...

  10. Accelerator Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator Science Accelerator Science ReframAccelerator.jpg Particle accelerators are among the largest, most complex, and most important scientific instruments in the world....

  11. Computer Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cite Seer Department of Energy provided open access science research citations in chemistry, physics, materials, engineering, and computer science IEEE Xplore Full text...

  12. Science Gateways

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    About Science Gateways A science gateway is a web-based interface to access HPC computers ... perform shared computations, and generally interact with NERSC resources over the web. ...

  13. Briefing: DOE and the Life and Medical Sciences

    Broader source: Energy.gov [DOE]

    Aristides Patrinos, Deputy Director for Research, NYU Center for Urban Science and Progress, discussed DOE and the Life and Medical Sciences in his presentation entitled, The Promise and Challenges of the Human Genome Program. Sharlene Weatherwax, Associate Director, Biological and Environmental Research, Office of Science, DOE, discussed DOE and the Life and Medical Sciences in her presentation entitled, The Department of Energy's Activities Supporting the Life and Medical Sciences.

  14. Is sustainability science really a science?

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Is sustainability science really a science? Is sustainability science really a science? The team's work shows that although sustainability science has been growing explosively ...

  15. The human genome project

    SciTech Connect (OSTI)

    Yager, T.D.; Zewert, T.E.; Hood, L.E. )

    1994-04-01

    The Human Genome Project (HGP) is a coordinated worldwide effort to precisely map the human genome and the genomes of selected model organisms. The first explicit proposal for this project dates from 1985 although its foundations (both conceptual and technological) can be traced back many years in genetics, molecular biology, and biotechnology. The HGP has matured rapidly and is producing results of great significance.

  16. Material Science and Nuclear Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Material Science and Nuclear Science Material Science and Nuclear Science National security depends on science and technology. The United States relies on Los Alamos National Laboratory for the best of both. No place on Earth pursues a broader array of world-class scientific endeavors. The Lab's four Science Pillars harness capabilities for solutions to threats- on national and global scales. Contact thumbnail of Business Development Business Development Richard P. Feynman Center for Innovation

  17. Statistical Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6 Statistical Sciences Applying statistical reasoning and rigor to multidisciplinary scientific investigations Contact Us Group Leader Joanne Wendelberger Email Deputy Group Leader James R. Gattiker Email Group Administrator LeeAnn Martinez (505) 667-3308 Email Statistical Sciences Statistical Sciences provides statistical reasoning and rigor to multidisciplinary scientific investigations and development, application, and communication of cutting-edge statistical sciences research. Statistical

  18. Explosives Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Explosives Science Explosives Science Current efforts in explosives science cover many areas critical to national security. One particular area is the need for countermeasures against explosive threats. v Comprehensive explosives process Los Alamos National Laboratory offers a comprehensive explosives process. This process leverages entire technical divisions dedicated to explosives science. Los Alamos scientists combine advanced expertise and capabilities with modern facilities. These assets

  19. Science Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Highlights Print Science Highlights Featured scientific research based on publications resulting from work done at the ALS. Highlights are nominated by management and beamline scientists for their scientific significance. Current highlights (2004-present), highlight archives (1995-2004), and Summary Slides of ALS Science Highlights are also available. Science Briefs Short reports on recent research submitted by ALS beamline scientists and users. Science Caf├ęs Informal lecture series

  20. Science Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Highlights Print Science Highlights Featured scientific research based on publications resulting from work done at the ALS. Highlights are nominated by management and beamline scientists for their scientific significance. Current highlights (2004-present), highlight archives (1995-2004), and Summary Slides of ALS Science Highlights are also available. Science Briefs Short reports on recent research submitted by ALS beamline scientists and users. Science Caf├ęs Informal lecture series

  1. Science Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Highlights Print Science Highlights Featured scientific research based on publications resulting from work done at the ALS. Highlights are nominated by management and beamline scientists for their scientific significance. Current highlights (2004-present), highlight archives (1995-2004), and Summary Slides of ALS Science Highlights are also available. Science Briefs Short reports on recent research submitted by ALS beamline scientists and users. Science Caf├ęs Informal lecture series

  2. Science Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Highlights Print Science Highlights Featured scientific research based on publications resulting from work done at the ALS. Highlights are nominated by management and beamline scientists for their scientific significance. Current highlights (2004-present), highlight archives (1995-2004), and Summary Slides of ALS Science Highlights are also available. Science Briefs Short reports on recent research submitted by ALS beamline scientists and users. Science Caf├ęs Informal lecture series

  3. Explore Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Explore Explore Science Create your own science adventure by exploring our varied exhibits, and learn what inspired our scientists, engineers and technicians to discover new things. August 18, 2014 boys conducting experiment [Science is] a great game. It is inspiring and refreshing. The playing field is the universe itself. -I.I. Rabi Science is thinking in an organized way about things. You don't need a license or permission to practice science. Scientists are interested in just about anything

  4. Genome sequence and annotation of Trichoderma parareesei, the ancestor of

    Office of Scientific and Technical Information (OSTI)

    the cellulase producer Trichoderma reesei (Journal Article) | DOE PAGES Genome sequence and annotation of Trichoderma parareesei, the ancestor of the cellulase producer Trichoderma reesei ┬ź Prev Next ┬╗ Title: Genome sequence and annotation of Trichoderma parareesei, the ancestor of the cellulase producer Trichoderma reesei ├Ś You are accessing a document from the Department of Energy's (DOE) Public Access Gateway for Energy & Science (PAGES). This site is a product of DOE's Office of

  5. INTEGRATED GENOME-BASED STUDIES OF SHEWANELLA ECOPHYSIOLOGY (Technical

    Office of Scientific and Technical Information (OSTI)

    Report) | SciTech Connect Technical Report: INTEGRATED GENOME-BASED STUDIES OF SHEWANELLA ECOPHYSIOLOGY Citation Details In-Document Search Title: INTEGRATED GENOME-BASED STUDIES OF SHEWANELLA ECOPHYSIOLOGY ├Ś You are accessing a document from the Department of Energy's (DOE) SciTech Connect. This site is a product of DOE's Office of Scientific and Technical Information (OSTI) and is provided as a public service. Visit OSTI to utilize additional information resources in energy science and

  6. Integrated Genome-Based Studies of Shewanella Ecophysiology (Technical

    Office of Scientific and Technical Information (OSTI)

    Report) | SciTech Connect Integrated Genome-Based Studies of Shewanella Ecophysiology Citation Details In-Document Search Title: Integrated Genome-Based Studies of Shewanella Ecophysiology ├Ś You are accessing a document from the Department of Energy's (DOE) SciTech Connect. This site is a product of DOE's Office of Scientific and Technical Information (OSTI) and is provided as a public service. Visit OSTI to utilize additional information resources in energy science and technology. A paper

  7. Genomics and Systems Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genomics and Systems Biology LANL leads the world in computational finishing of microbial genomes Read caption + In 2013, Los Alamos scientist Richard Sayre and his team genetically modified the organisms to harvest light more efficiently for maximum production. Overview of Research and Highlights Researchers at Los Alamos National Laboratory are using their renowned expertise in genomics, computation, and experimental biology as the foundation of a dynamic systems biology capability. Systems

  8. Insights from twenty years of bacterial genome sequencing

    SciTech Connect (OSTI)

    Land, Miriam L; Hauser, Loren John; Jun, Se Ran; Nookaew, Intawat; Leuze, Michael Rex; Ahn, Tae-Hyuk; Karpinets, Tatiana V; Lund, Ole; Kora, Guruprasad H; Wassenaar, Trudy; Poudel, Suresh; Ussery, David W

    2015-01-01

    Since the first two complete bacterial genome sequences were published in 1995, the science of bacteria has dramatically changed. Using third-generation DNA sequencing, it is possible to completely sequence a bacterial genome in a few hours and identify some types of methylation sites along the genome as well. Sequencing of bacterial genome sequences is now a standard procedure, and the information from tens of thousands of bacterial genomes has had a major impact on our views of the bacterial world. In this review, we explore a series of questions to highlight some insights that comparative genomics has produced. To date, there are genome sequences available from 50 different bacterial phyla and 11 different archaeal phyla. However, the distribution is quite skewed towards a few phyla that contain model organisms. But the breadth is continuing to improve, with projects dedicated to filling in less characterized taxonomic groups. The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system provides bacteria with immunity against viruses, which outnumber bacteria by tenfold. How fast can we go? Second-generation sequencing has produced a large number of draft genomes (close to 90 % of bacterial genomes in GenBank are currently not complete); third-generation sequencing can potentially produce a finished genome in a few hours, and at the same time provide methlylation sites along the entire chromosome. The diversity of bacterial communities is extensive as is evident from the genome sequences available from 50 different bacterial phyla and 11 different archaeal phyla. Genome sequencing can help in classifying an organism, and in the case where multiple genomes of the same species are available, it is possible to calculate the pan- and core genomes; comparison of more than 2000 Escherichia coli genomes finds an E. coli core genome of about 3100 gene families and a total of about 89,000 different gene families. Why do we care about bacterial genome sequencing? There are many practical applications, such as genome-scale metabolic modeling, biosurveillance, bioforensics, and infectious disease epidemiology. In the near future, high-throughput sequencing of patient metagenomic samples could revolutionize medicine in terms of speed and accuracy of finding pathogens and knowing how to treat them.

  9. NREL Support for a Functional Genomics Approach to Investigate Regulation of Phenolic Glycoside: Cooperative Research and Development Final Report, CRADA number CRD-07-00218

    SciTech Connect (OSTI)

    Davis, M.

    2010-07-01

    NREL and MTU collaborated on a proposal 'A Functional Genomics Approach to Investigate Regulation of Phenolic Glycoside Metabolism in Populus' funded by the National Science Foundation.

  10. Science Briefs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    feed-image Digg: ALSBerkeleyLab Facebook Page: 208064938929 Flickr: advancedlightsource Twitter: AdvLightSource YouTube: AdvancedLightSource Home Science Highlights Science Briefs Science Briefs ALS Science Briefs are short (200 words maximum) descriptions of recently published ALS-related work. These "brief" highlights also include one image, a caption (50 words), and the publication citation. All ALS users and beamline scientists are invited to fill out the short submission form here

  11. Science Facilities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Facilities /science-innovation/_assets/images/icon-science.jpg Science Facilities The focal point for basic and applied R&D programs with a primary focus on energy but also encompassing medical, biotechnology, high-energy physics, and advanced scientific computing programs. Center for Integrated Nanotechnologies┬╗ Dual Axis Radiographic Hydrodynamic Test Facility (DARHT)┬╗ Electron Microscopy Lab┬╗ Ion Beam Materials Lab┬╗ Isotope Production Facility┬╗ Los Alamos Neutron Science Center┬╗

  12. Science Programs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Programs /science-innovation/_assets/images/icon-science.jpg Science Programs The focal point for basic and applied R&D programs with a primary focus on energy but also encompassing medical, biotechnology, high-energy physics, and advanced scientific computing programs. Applied Energy Programs┬╗ Civilian Nuclear Programs┬╗ Laboratory Directed Research & Development┬╗ Office of Science┬╗

  13. Big Science

    ScienceCinema (OSTI)

    Dr. Thomas Zacharia

    2010-01-08

    Big science seeks big solutions for the most urgent problems of our times. Video courtesy Cray, Inc.

  14. Fungal Genomics Program

    SciTech Connect (OSTI)

    Grigoriev, Igor

    2012-03-12

    The JGI Fungal Genomics Program aims to scale up sequencing and analysis of fungal genomes to explore the diversity of fungi important for energy and the environment, and to promote functional studies on a system level. Combining new sequencing technologies and comparative genomics tools, JGI is now leading the world in fungal genome sequencing and analysis. Over 120 sequenced fungal genomes with analytical tools are available via MycoCosm (www.jgi.doe.gov/fungi), a web-portal for fungal biologists. Our model of interacting with user communities, unique among other sequencing centers, helps organize these communities, improves genome annotation and analysis work, and facilitates new larger-scale genomic projects. This resulted in 20 high-profile papers published in 2011 alone and contributing to the Genomics Encyclopedia of Fungi, which targets fungi related to plant health (symbionts, pathogens, and biocontrol agents) and biorefinery processes (cellulose degradation, sugar fermentation, industrial hosts). Our next grand challenges include larger scale exploration of fungal diversity (1000 fungal genomes), developing molecular tools for DOE-relevant model organisms, and analysis of complex systems and metagenomes.

  15. Genomics Division Home

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to the most primitive soil microbe represent a watershed opportunity for biology. The Genomics Division is taking advantage of this wealth of new information. While it is well...

  16. Human Genome: DOE Origins

    Office of Scientific and Technical Information (OSTI)

    of the Department of Energy; DOE Technical Report; 1988 Mapping and Sequencing the Human Genome; DOE Technical Report; 1988 Understanding our Genetic Inheritance: The U.S....

  17. Huazhong Science Technology University Yongtai Science Technology...

    Open Energy Info (EERE)

    Huazhong Science Technology University Yongtai Science Technology Co Ltd Jump to: navigation, search Name: Huazhong Science & Technology University Yongtai Science & Technology Co...

  18. Environmental Molecular Sciences Laboratory (EMSL) | U.S. DOE Office of

    Office of Science (SC) Website

    Science (SC) Environmental Molecular Sciences Laboratory (EMSL) Biological and Environmental Research (BER) BER Home About Research Facilities User Facilities Atmospheric Radiation Measurement Climate Research Facility (ARM) Environmental Molecular Sciences Laboratory (EMSL) Joint Genome Institute (JGI) Science Highlights Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) Community Resources Contact Information Biological and

  19. Funding Opportunities | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Opportunities Funding Opportunities Funding Opportunities Home Grants & Contracts Support Award Search / Public Abstracts Find Funding Early Career Research Program Statement on Digital Data Management Acknowledgements of Federal Support Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 JGI Illumina Genome Sequencers BNL Joint Genome Institute genome sequencers. (Lawrence Berkeley National Laboratory) Print Text

  20. Climate & Earth Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human-Induced Climate Change Reduces Chance of Flooding in Okavango Delta Energy Science Engineering Science Environmental Science Fusion Science Math & Computer Science Nuclear...

  1. Science DMZ for ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Science Engagement Move your data Programs & Workshops Science Requirements Reviews Case Studies OSCARS Case Studies Science DMZ Case Studies Science DMZ @ UF Science DMZ @ CU...

  2. The Future of Microbial Genomics

    SciTech Connect (OSTI)

    Kyrpides, Nikos [Genome Biology group at the DOE Joint Genome Institute

    2010-06-02

    Nikos Kyrpides, head of the Genome Biology group at the DOE Joint Genome Institute discusses current challenges in the field of microbial genomics on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  3. Science DMZ Case Studies

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science DMZ Case Studies Science DMZ @ UF Science DMZ @ CU Science DMZ @ Penn & VTTI Science DMZ @ NOAA Science DMZ @ NERSC Science DMZ @ ALS Multi-facility Workflow Case Study...

  4. SciTech Connect: genomics

    Office of Scientific and Technical Information (OSTI)

    genomics Find + Advanced Search Term Search Semantic Search Advanced Search All Fields: genomics Semantic Semantic Term Title: Full Text: Bibliographic Data: Creator Author:...

  5. USDA-DOE Make Available $4 Million for Biomass Genomics Research | U.S. DOE

    Office of Science (SC) Website

    Office of Science (SC) USDA-DOE Make Available $4 Million for Biomass Genomics Research News News Home Featured Articles Science Headlines 2015 2014 2013 2016 2012 2011 2010 2009 2008 2007 2006 2005 Science Highlights Presentations & Testimony News Archives Communications and Public Affairs Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 10.12.06 USDA-DOE Make Available $4 Million for Biomass Genomics

  6. Photon Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Photon Science Along with its primary missions-global security, energy security, basic science, and national competitiveness-the NIF & Photon Science Directorate also pursues research and development projects to innovate and develop cutting-edge technologies in support of those missions. This effort strategically invests in new technologies and development of large-scale photon systems for various federal agencies and industry sponsors. NIF&PS researchers are developing world-class

  7. Fermilab | Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    feature photo feature photo feature photo feature photo feature photo Science Navbar Toggle About Quick Info Science History Organization Photo and video gallery Diversity Education Safety Sustainability and environment Contact Newsroom Spotlight Press releases Fact sheets and brochures symmetry Interactions.org Photo and video archive Resources for ... Employees Researchers, Postdocs and Graduate Students Job Seekers Neighbors Industry K-12 Students, Teachers and Undergraduates Media Science

  8. Fire Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion ...

  9. Information Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Information Science and Technology (ASIS&T) American Society for Indexing (ASI) Digital Library Federation (DLF) National Archives and Records Administration (NARA) Special...

  10. SCIENCE Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Program early science program Early at the Argonne Leadership Computing Facility CONTACT Argonne Leadership Computing Facility | www.alcf.anl.gov | (877) 737-8615...

  11. Energy Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Materials Scientists are advancing the fundamental science of materials within the context of global energy-related challenges. They are developing experimental and theoretical...

  12. Eukaryotic Genomics Data from the DOE Joint Genome Institute (JGI)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    From the JGI webportal users can choose Eukaryotic genomes from a photo list, access the JGI FTP directories to download data files, use the Tree of Life navigation tool, or choose a genome and go directly to a website specific to that one genome. The individual sites include direct access to download sequence files, BLAST, search, view and navigate the genomic annotations.

  13. Human Genome Education Program

    SciTech Connect (OSTI)

    Richard Myers; Lane Conn

    2000-05-01

    The funds from the DOE Human Genome Program, for the project period 2/1/96 through 1/31/98, have provided major support for the curriculum development and field testing efforts for two high school level instructional units: Unit 1, ''Exploring Genetic Conditions: Genes, Culture and Choices''; and Unit 2, ''DNA Snapshots: Peaking at Your DNA''. In the original proposal, they requested DOE support for the partial salary and benefits of a Field Test Coordinator position to: (1) complete the field testing and revision of two high school curriculum units, and (2) initiate the education of teachers using these units. During the project period of this two-year DOE grant, a part-time Field-Test Coordinator was hired (Ms. Geraldine Horsma) and significant progress has been made in both of the original proposal objectives. Field testing for Unit 1 has occurred in over 12 schools (local and non-local sites with diverse student populations). Field testing for Unit 2 has occurred in over 15 schools (local and non-local sites) and will continue in 12-15 schools during the 96-97 school year. For both curricula, field-test sites and site teachers were selected for their interest in genetics education and in hands-on science education. Many of the site teachers had no previous experience with HGEP or the unit under development. Both of these first-year biology curriculum units, which contain genetics, biotechnology, societal, ethical and cultural issues related to HGP, are being implemented in many local and non-local schools (SF Bay Area, Southern California, Nebraska, Hawaii, and Texas) and in programs for teachers. These units will reach over 10,000 students in the SF Bay Area and continues to receive support from local corporate and private philanthropic organizations. Although HGEP unit development is nearing completion for both units, data is still being gathered and analyzed on unit effectiveness and student learning. The final field testing result from this analysis will contribute to the final revisions of each unit during the second-year of this grant.

  14. Human Genome Program

    SciTech Connect (OSTI)

    Not Available

    1993-01-01

    The DOE Human Genome program has grown tremendously, as shown by the marked increase in the number of genome-funded projects since the last workshop held in 1991. The abstracts in this book describe the genome research of DOE-funded grantees and contractors and invited guests, and all projects are represented at the workshop by posters. The 3-day meeting includes plenary sessions on ethical, legal, and social issues pertaining to the availability of genetic data; sequencing techniques, informatics support; and chromosome and cDNA mapping and sequencing.

  15. Genomic library construction

    DOE Patents [OSTI]

    Church, George M.; Zhang, Kun

    2011-07-26

    Compositions and methods for amplifying nucleic acid sequences from a single cell are provided. Compositions and methods for constructing a genomic library from a single cell are also provided.

  16. Integrative Genomics Building

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Integrative Genomics Building Community Berkeley Global Campus Environmental Documents Tours Community Programs Friends of Berkeley Lab Ôçĺ Navigate Section Community Berkeley Global Campus Environmental Documents Tours Community Programs Friends of Berkeley Lab Project Description The Integrative Genomics Building (IGB) is proposed to be an approximately 77,000 gsf, four-story research and office building constructed in the former Bevatron area - a fully developed site in the geographic

  17. **Science on Saturday EXTENDED** March 19 2016: Science on Saturday: Using

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics and Chemistry to Understand the Genome | Princeton Plasma Physics Lab Events Saturday, March 19, 2016 - 09:30 **Science on Saturday EXTENDED** March 19 2016: Science on Saturday: Using Physics and Chemistry to Understand the Genome Join us for our special extended week of our lecture series; Dr. Ondrechen will close out our 2016 SoS season! LIVE STREAMING LINK: https://mediacentral.princeton.edu/id/1_wdp1m3et Twwet us your questions @PPPLSciEd and/or #scionsat PPPL, MBG Auditorium

  18. DIVERSITY. EDUCATION. SCIENCE. The ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Sciences-Biology, Computer, Information Technology, Geology, Mathematics, Microbiology, and Physics. Social Sciences-Economics, Organizational Psychology, Political Science, ...

  19. NREL: Energy Sciences - Chemical and Materials Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in the U.S. Department of Energy (DOE) National Photovoltaic Program and DOE Basic Energy Sciences Program. Materials Science. The Materials Science Group's research...

  20. National Security Science Archive

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science NSS Archive National Security Science Latest Issue:July 2015 past issues All Issues submit National Security Science Archive National Security Science magazine...

  1. Science Magazine

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    & ANALYSIS www.sciencemag.org SCIENCE VOL 339 8 FEBRUARY 2013 635 Steven Chu, the fi rst Nobel-winning scien- tist to lead the sprawling U.S. Department of Energy (DOE), has rarely...

  2. Neal Lane: Confessions of a President's Science Advisor

    ScienceCinema (OSTI)

    Neal Lane

    2010-09-01

    Former science advisor to president Bill Clinton Neal Lane briefly reviews the history of the job of Science Advisor to the President and give some examples of issues he had to deal with when he was in that position, including climate change, stem cell research, the human genome, nanotechnology and research funding. He will also give his opinions about the present and future state of science in the U.S.

  3. Science Museum

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nanotechnology and algae biofuels exhibits open July 26 at the Bradbury Science Museum July 22, 2013 LOS ALAMOS, N.M., July 22, 2013-Los Alamos National Laboratory's Bradbury Science Museum is opening two new exhibits July 26 as part of the Laboratory's 70th Anniversary celebration. One is a nanotechnology exhibit featuring the Laboratory's Center for Integrated Nanotechnologies (CINT) and the other is an algae biofuel exhibit from the Laboratory and the New Mexico Consortium. An opening

  4. Isotope Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science and Production 35 years of experience in isotope production, processing, and applications. Llllll Committed to the safe and reliable production of radioisotopes, products, and services. Contact: Kevin John LANL Isotope Program Manager kjohn@lanl.gov 505-667-3602 Sponsored by the Department of Energy National Isotope Program http://www.nuclear.energy.gov/isotopes/nelsotopes2a.html Isotopes for Environmental Science Isotopes produced at Los Alamos National Laboratory are used as

  5. Energy Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Science Energy Science Print Our current fossil-fuel-based system is causing potentially catastrophic changes to our planet. The quest for renewable, nonpolluting sources of energy requires us to understand, predict, and ultimately control matter and energy at the electronic, atomic, and molecular levels. Light-source facilities-the synchrotrons of today and the next-generation light sources of tomorrow-are the scientific tools of choice for exploring the electronic and atomic structure

  6. Science Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Highlights Science Highlights Science highlights feature research conducted by staff and users at the ALS. If a Power Point summary slide or a PDF handout of the highlight is available, you will find it linked beneath the highlight listing and on the highlight's page. You may also print a version of a highlight by clicking the print icon associated with each highlight. Manganese Reduction-Oxidation Drives Plant Debris Decomposition Print Monday, 22 February 2016 00:00 ALS research has shown that

  7. Measurement Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    wins 2016 Joseph F. Keithley Award for Advances in Measurement Science October 15, 2015 Honors to Albert Migliori, developer of resonant ultrasound spectroscopy LOS ALAMOS, N.M., Oct. 15, 2015-Los Alamos National Laboratory physicist Albert Migliori, having led the development of a powerful tool for important measurements in condensed matter physics including superconductivity, is being given the Joseph F. Keithley Award For Advances in Measurement Science, the top instrumentation prize of the

  8. Nuclear Science

    Energy Savers [EERE]

    and Engineering Education Sourcebook 2013 American Nuclear Society US Department of Energy Nuclear Science & Engineering Education Sourcebook 2013 North American Edition American Nuclear Society Education, Training, and Workforce Division US Department of Energy Office of Nuclear Energy Editor and Founder John Gilligan Professor of Nuclear Engineering North Carolina State University Version 5.13 Welcome to the 2013 Edition of the Nuclear Science and Engineering Education (NS&EE)

  9. What Makes Science, Science? Research, Shared Effort ... & A...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Makes Science, Science? Research, Shared Effort ... & A New Office of Science Website What Makes Science, Science? Research, Shared Effort ... & A New Office of Science Website ...

  10. Berkeley Quantitative Genome Browser

    Energy Science and Technology Software Center (OSTI)

    2008-02-29

    The Berkeley Quantitative Genome Browser provides graphical browsing functionality for genomic data organized, at a minimum, by sequence and position. While supporting the annotation browsing features typical of many other genomic browsers, additional emphasis is placed on viewing and utilizing quantitative data. Data may be read from GFF, SGR, FASTA or any column delimited format. Once the data has been read into the browser's buffer, it may be searched. filtered or subjected to mathematical transformation.more┬á┬╗ The browser also supplies some graphical design manipulation functionality geared towards preparing figures for presentations or publication. A plug-in mechanism enables development outside the core functionality that adds more advanced or esoteric analysis capabilities. BBrowse's development and distribution is open-source and has been built to run on Linux, OSX and MS Windows operating systems.┬ź┬áless

  11. Microbial Genomics Data from the DOE Joint Genome Institute (JGI)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    As of March 2008, The Joint Genome Institute has released 296 Prokaryotic microbial sites, with 216 in finished status.

  12. Human Genome: DOE Origins

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DOE Origins Resources with Additional Information Charles DeLisi Charles DeLisi The genesis of the Department of Energy (DOE) human genome project took place when "Charles DeLisi ... conceived of a concerted effort to sequence the human genome under the aegis of the ... DOE. ... In 1985, DeLisi took the reins of DOE's Office of Health and Environmental Research [OHER], the program that supported most Biology in the Department. The origins of DOE's biology program traced to the Manhattan

  13. Science Museum

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Maintaining nuclear stability in times of transition focus of talk at Bradbury Science Museum January 9, 2014 First in series of evening lectures open to public LOS ALAMOS, N.M., Jan. 9, 2014-Los Alamos National Laboratory Senior Fellow Houston "Terry" Hawkins talks about the role that the nation's nuclear weapons stockpile plays in maintaining the nation's defense - and that of our allies - in a talk at 5:30 p.m., Jan. 15 at the Bradbury Science Museum. The talk is the first in a

  14. Science Museum

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Emerging threats to global security focus of March 12 talk at Bradbury Science Museum March 6, 2014 Terry Wallace to address Lab's role in helping the government meet national security challenges LOS ALAMOS, N.M., March 6, 2014-Terry Wallace, principal associate director for Global Security at Los Alamos National Laboratory, will talk about potential emerging threats in a lecture at 5:30 p.m., March 12 at the Bradbury Science Museum. The talk is the third in a series of evening lectures planned

  15. Origins of the Human Genome Project

    DOE R&D Accomplishments [OSTI]

    Cook-Deegan, Robert (Affiliation: Institute of Medicine, National Academy of Sciences)

    1993-07-01

    The human genome project was borne of technology, grew into a science bureaucracy in the United States and throughout the world, and is now being transformed into a hybrid academic and commercial enterprise. The next phase of the project promises to veer more sharply toward commercial application, harnessing both the technical prowess of molecular biology and the rapidly growing body of knowledge about DNA structure to the pursuit of practical benefits. Faith that the systematic analysis of DNA structure will prove to be a powerful research tool underlies the rationale behind the genome project. The notion that most genetic information is embedded in the sequence of CNA base pairs comprising chromosomes is a central tenet. A rough analogy is to liken an organism's genetic code to computer code. The coal of the genome project, in this parlance, is to identify and catalog 75,000 or more files (genes) in the software that directs construction of a self-modifying and self-replicating system -- a living organism.

  16. Information Science, Computing, Applied Math

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Capabilities Information Science, Computing, Applied Math science-innovationassetsimagesicon-science.jpg Information Science, Computing, Applied Math National security ...

  17. DOE Joint Genome Institute 2008 Progress Report

    SciTech Connect (OSTI)

    Gilbert, David

    2009-03-12

    While initially a virtual institute, the driving force behind the creation of the DOE Joint Genome Institute in Walnut Creek, California in the Fall of 1999 was the Department of Energy's commitment to sequencing the human genome. With the publication in 2004 of a trio of manuscripts describing the finished 'DOE Human Chromosomes', the Institute successfully completed its human genome mission. In the time between the creation of the Department of Energy Joint Genome Institute (DOE JGI) and completion of the Human Genome Project, sequencing and its role in biology spread to fields extending far beyond what could be imagined when the Human Genome Project first began. Accordingly, the targets of the DOE JGI's sequencing activities changed, moving from a single human genome to the genomes of large numbers of microbes, plants, and other organisms, and the community of users of DOE JGI data similarly expanded and diversified. Transitioning into operating as a user facility, the DOE JGI modeled itself after other DOE user facilities, such as synchrotron light sources and supercomputer facilities, empowering the science of large numbers of investigators working in areas of relevance to energy and the environment. The JGI's approach to being a user facility is based on the concept that by focusing state-of-the-art sequencing and analysis capabilities on the best peer-reviewed ideas drawn from a broad community of scientists, the DOE JGI will effectively encourage creative approaches to DOE mission areas and produce important science. This clearly has occurred, only partially reflected in the fact that the DOE JGI has played a major role in more than 45 papers published in just the past three years alone in Nature and Science. The involvement of a large and engaged community of users working on important problems has helped maximize the impact of JGI science. A seismic technological change is presently underway at the JGI. The Sanger capillary-based sequencing process that dominated how sequencing was done in the last decade is being replaced by a variety of new processes and sequencing instruments. The JGI, with an increasing number of next-generation sequencers, whose throughput is 100- to 1,000-fold greater than the Sanger capillary-based sequencers, is increasingly focused in new directions on projects of scale and complexity not previously attempted. These new directions for the JGI come, in part, from the 2008 National Research Council report on the goals of the National Plant Genome Initiative as well as the 2007 National Research Council report on the New Science of Metagenomics. Both reports outline a crucial need for systematic large-scale surveys of the plant and microbial components of the biosphere as well as an increasing need for large-scale analysis capabilities to meet the challenge of converting sequence data into knowledge. The JGI is extensively discussed in both reports as vital to progress in these fields of major national interest. JGI's future plan for plants and microbes includes a systematic approach for investigation of these organisms at a scale requiring the special capabilities of the JGI to generate, manage, and analyze the datasets. JGI will generate and provide not only community access to these plant and microbial datasets, but also the tools for analyzing them. These activities will produce essential knowledge that will be needed if we are to be able to respond to the world's energy and environmental challenges. As the JGI Plant and Microbial programs advance, the JGI as a user facility is also evolving. The Institute has been highly successful in bending its technical and analytical skills to help users solve large complex problems of major importance, and that effort will continue unabated. The JGI will increasingly move from a central focus on 'one-off' user projects coming from small user communities to much larger scale projects driven by systematic and problem-focused approaches to selection of sequencing targets. Entire communities of scientists working in a particular field, such as feedstock improvement or biomass degradation, will be users of this information. Despite this new emphasis, an investigator-initiated user program will remain. This program in the future will replace small projects that increasingly can be accomplished without the involvement of JGI, with imaginative large-scale 'Grand Challenge' projects of foundational relevance to energy and the environment that require a new scale of sequencing and analysis capabilities. Close interactions with the DOE Bioenergy Research Centers, and with other DOE institutions that may follow, will also play a major role in shaping aspects of how the JGI operates as a user facility. Based on increased availability of high-throughput sequencing, the JGI will increasingly provide to users, in addition to DNA sequencing, an array of both pre- and post-sequencing value-added capabilities to accelerate their science.

  18. Top Science of 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    RAPTOR telescope witnesses black hole birth science-innovationassetsimagesicon-science.jpg Top Science of 2013 Our strong interdisciplinary teaming and unique research...

  19. Top Science of 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Liquid-scanning technology boosts airport security science-innovationassetsimagesicon-science.jpg Top Science of 2013 Our strong interdisciplinary teaming and unique research...

  20. National Security Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science National Security Science Latest Issue:July 2015 past issues All Issues submit National Security Science Showcasing Los Alamos National Laboratory's work on nuclear...

  1. ARM - Key Science Questions

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    govScienceKey Science Questions Science Research Themes Research Highlights Journal Articles Collaborations Atmospheric System Research (ASR) Earth System Modeling Regional &...

  2. Top Science of 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roadrunner firsts pave way for greener, faster supercomputing science-innovationassetsimagesicon-science.jpg Top Science of 2013 Our strong interdisciplinary teaming and ...

  3. Nuclear Science & Technology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nuclear Science & Technology Nuclear Science & Technology1354608000000Nuclear Science & TechnologySome of these resources are LANL-only and will require Remote Access. No...

  4. Is sustainability science really a science?

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Is sustainability science really a science? Is sustainability science really a science? The team's work shows that although sustainability science has been growing explosively since the late 1980s, only in the last decade has the field matured into a cohesive area of science. November 22, 2011 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience,

  5. Energy Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Science Print Our current fossil-fuel-based system is causing potentially catastrophic changes to our planet. The quest for renewable, nonpolluting sources of energy requires us to understand, predict, and ultimately control matter and energy at the electronic, atomic, and molecular levels. Light-source facilities-the synchrotrons of today and the next-generation light sources of tomorrow-are the scientific tools of choice for exploring the electronic and atomic structure of matter. As

  6. Fire Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs Advanced Nuclear Energy

  7. Chemical Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chemical Sciences - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs Advanced

  8. Computational Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs Advanced Nuclear Energy

  9. Discovery Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Discovery Science Since the beginning of civilization, humans have marveled at the night sky and pondered the vast stretches of the universe. The invention of telescopes in the 17th century revealed the first details of the Moon and the planets in our solar system. Four hundred years later, space-based observatories such as NASA's Hubble and Kepler regularly capture amazing vistas of billions of galaxies millions of light years away. Despite these advances, astronomers have only been able to

  10. Information Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 Information Sciences Uncovering actionable knowledge and generating insight into exascale datasets from heterogeneous sources in real time Leadership Group Leader Patrick M. Kelly Email Deputy Group Leader Amy Larson Email Contact Us Administrator Yvonne McKelvey Email Conceptual illustration of futuristic data stream processing. Developing methods and tools for understanding complex interactions and extracting actionable information from massive data streams. Basic and applied research

  11. Science DMZ Implemented at NERSC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NERSC Science Engagement Move your data Programs & Workshops Science Requirements Reviews Case Studies OSCARS Case Studies Science DMZ Case Studies Science DMZ @ UF Science DMZ @...

  12. EXTENDED! Science on Saturday: Using Physics and Chemistry to Understand

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the Genome | Princeton Plasma Physics Lab 9, 2016, 9:30am Science On Saturday PPPL, MBG Auditorium EXTENDED! Science on Saturday: Using Physics and Chemistry to Understand the Genome Professor Mary Jo Ondrechen Northeastern University Abstract: PDF icon 03 Ondrechen-1.pdf ***ATTENTION*** Join us as Dr. Ondrechen gives her talk at our final lecture of the series on March 19, 2016- same time, same place! LIVE STREAMING LINK: https://mediacentral.princeton.edu/id/1_wdp1m3et Contact Information

  13. The Los Alamos Science Pillars The Science of Signatures

    SciTech Connect (OSTI)

    Smith, Joshua E.; Peterson, Eugene J.

    2012-09-13

    As a national security science laboratory, Los Alamos is often asked to detect and measure the characteristics of complex systems and to use the resulting information to quantify the system's behavior. The Science of Signatures (SoS) pillar is the broad suite of technical expertise and capability that we use to accomplish this task. With it, we discover new signatures, develop new methods for detecting or measuring signatures, and deploy new detection technologies. The breadth of work at Los Alamos National Laboratory (LANL) in SoS is impressive and spans from the initial understanding of nuclear weapon performance during the Manhattan Project, to unraveling the human genome, to deploying laser spectroscopy instrumentation on Mars. Clearly, SoS is a primary science area for the Laboratory and we foresee that as it matures, new regimes of signatures will be discovered and new ways of extracting information from existing data streams will be developed. These advances will in turn drive the development of sensing instrumentation and sensor deployment. The Science of Signatures is one of three science pillars championed by the Laboratory and vital to supporting our status as a leading national security science laboratory. As with the other two pillars, Materials for the Future and Information Science and Technology for Predictive Science (IS&T), SoS relies on the integration of technical disciplines and the multidisciplinary science and engineering that is our hallmark to tackle the most difficult national security challenges. Over nine months in 2011 and 2012, a team of science leaders from across the Laboratory has worked to develop a SoS strategy that positions us for the future. The crafting of this strategy has been championed by the Chemistry, Life, and Earth Sciences Directorate, but as you will see from this document, SoS is truly an Institution-wide effort and it has engagement from every organization at the Laboratory. This process tapped the insight and imagination of many LANL staff and managers and resulted in a strategy which focuses on our strengths while recognizing that the science of signatures is dynamic. This report highlights the interdependence between SoS, advances in materials science, and advances in information technology. The intent is that SoS shape and inform Los Alamos investments in nuclear forensics, nuclear diagnostics, climate, space, energy, and biosurveillence; the areas of leadership that you will read about in this strategy document. The Science of Signatures is still a relatively new strategic direction for the Laboratory. The primary purpose of this document is tell Laboratory staff how SoS is being managed and give them a chance to get involved. A second important purpose is to inform the Department of Energy and our customers of our capability growth in this important scientific area. Questions concerning the SoS strategy and input to it are welcomed and may be directed to any member of the SoS Leadership Council or to the Chemistry, Life, and Earth Science Directorate Office.

  14. The OME Framework for genome-scale systems biology

    SciTech Connect (OSTI)

    Palsson, Bernhard O.; Ebrahim, Ali; Federowicz, Steve

    2014-12-19

    The life sciences are undergoing continuous and accelerating integration with computational and engineering sciences. The biology that many in the field have been trained on may be hardly recognizable in ten to twenty years. One of the major drivers for this transformation is the blistering pace of advancements in DNA sequencing and synthesis. These advances have resulted in unprecedented amounts of new data, information, and knowledge. Many software tools have been developed to deal with aspects of this transformation and each is sorely needed [1-3]. However, few of these tools have been forced to deal with the full complexity of genome-scale models along with high throughput genome- scale data. This particular situation represents a unique challenge, as it is simultaneously necessary to deal with the vast breadth of genome-scale models and the dizzying depth of high-throughput datasets. It has been observed time and again that as the pace of data generation continues to accelerate, the pace of analysis significantly lags behind [4]. It is also evident that, given the plethora of databases and software efforts [5-12], it is still a significant challenge to work with genome-scale metabolic models, let alone next-generation whole cell models [13-15]. We work at the forefront of model creation and systems scale data generation [16-18]. The OME Framework was borne out of a practical need to enable genome-scale modeling and data analysis under a unified framework to drive the next generation of genome-scale biological models. Here we present the OME Framework. It exists as a set of Python classes. However, we want to emphasize the importance of the underlying design as an addition to the discussions on specifications of a digital cell. A great deal of work and valuable progress has been made by a number of communities [13, 19-24] towards interchange formats and implementations designed to achieve similar goals. While many software tools exist for handling genome-scale metabolic models or for genome-scale data analysis, no implementations exist that explicitly handle data and models concurrently. The OME Framework structures data in a connected loop with models and the components those models are composed of. This results in the first full, practical implementation of a framework that can enable genome-scale design-build-test. Over the coming years many more software packages will be developed and tools will necessarily change. However, we hope that the underlying designs shared here can help to inform the design of future software.

  15. Science Brief Submission Form

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Brief Submission Form Science Brief Submission Form Print Tuesday, 01 May 2007 00:00 Loading... < Prev

  16. Science and Innovation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Innovation /science-innovation/_assets/images/icon-science.jpg Science and Innovation Our strong interdisciplinary teaming and unique research facilities allow us to develop solutions to complex problems, and to support partners and collaborators, all with the goal of strengthening national security and making a safer world. Science & Engineering Capabilities┬╗ Science Programs┬╗ Science Facilities┬╗ Features┬╗ Capabilities Strategy: Science Pillars┬╗ Top Ten Innovations of 2013 Science and

  17. Science Cafe

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Caf├ęs Science Cafe April 27, 2015-Special ALS Colloquium Print Wednesday, 22 April 2015 13:19 Special Event on Monday, April 27 @ 12 noon, USB 15-253 X-Ray Microscopy: The First 120 Years Janos Kirz, ALS Abstract R├Ântgen's great discovery became an instant public sensation. Fascination with the "new kind of rays" that could reveal the structure of opaque objects swept the world in 1896. Fifty years later it was widely recognized that the short wavelength of the radiation should open

  18. Bradbury Science Museum - Science on Wheels

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bradbury Science Museum - Science on Wheels Our Mission: To stimulate interest in and enthusiasm for science, technology, engineering and mathematics and promote public understanding and appreciation of Los Alamos National Laboratory Our Vision: The public interested in and excited about science, technology, engineering and mathematics, and the work of Los Alamos National Laboratory Program Description During the school year, the Bradbury Science Museum Educators drive there van to schools

  19. GPFS for Life Sciences at NERSC-- GPFSug 2015.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NERSC & JGI collaborative effort! Jason Hick, Rei Lee, Ravi Cheema, and Kjiersten Fagnan! ! GPFS User Group meeting! GPFS for Life Sciences at NERSC --- 1 --- May 2 0, 2 015 Overview of Bioinformatics --- 2 --- A High-level Summary --- 3 --- Bioenergy Carbon C ycling Biogeochemistry Metagenomes Plants Fungi Microbes DNA S ynthesis Science DNA Sequencing Advanced Genomic Technologies ComputaFonal Analysis DNA S ynthesis Metagenome Analysis --- 4 --- Reads (short segments of DNA) generated by

  20. Office of Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Office of Science /science-innovation/_assets/images/icon-science.jpg Office of Science Enabling remarkable discoveries and tools that transform our understanding of energy and matter and advance national, economic, and energy security. Advanced Scientific Computing Research┬╗ Basic Energy Sciences┬╗ Biological and Environmental Research┬╗ Fusion Energy Sciences┬╗ High Energy Physics┬╗ Nuclear Physics┬╗ Fusion Energy Science Research LANL fusion materials researchers use Titan supercomputer to

  1. Capabilities: Science Pillars

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pillars /science-innovation/_assets/images/icon-science.jpg Capabilities: Science Pillars The Lab's four Science Pillars harness our scientific capabilities for national security solutions. What are the Los Alamos National Laboratory's Science Pillars? The Laboratory has established the Science Pillars under four main themes to bring together the Laboratory's diverse array of scientific capabilities and expertise: Information, Science, and Technology Pillar Materials for the Future Pillar

  2. Closing Keynote Presentation on the Genomics of Energy and the Environment (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    SciTech Connect (OSTI)

    Benner, Stephen [Foundation for Applied Molecular Evolution, Westheimer Institute of Science and Technology] [Foundation for Applied Molecular Evolution, Westheimer Institute of Science and Technology

    2012-03-22

    Steve Benner, a distinguished chemist at the Foundation for Applied Molecular Evolution, Westheimer Institute of Science and Technology, provides the closing keynote address for the JGI 7th Annual Users Meeting: Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, California.

  3. Closing Keynote Presentation on the Genomics of Energy and the Environment (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    ScienceCinema (OSTI)

    Benner, Stephen [Foundation for Applied Molecular Evolution, Westheimer Institute of Science and Technology

    2013-01-22

    Steve Benner, a distinguished chemist at the Foundation for Applied Molecular Evolution, Westheimer Institute of Science and Technology, provides the closing keynote address for the JGI 7th Annual Users Meeting: Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, California.

  4. Genome patent fight erupts

    SciTech Connect (OSTI)

    Roberts, L.

    1991-10-11

    At a Congressional briefing while describing a new project to sequence partially every gene active in the human brain, it was made known that the National Institutes of Health was planning to file patent applications on 1,000 of these sequences a month. The scheme has engendered a firestorm of criticism from genome scientists and project officials alike. The critics argue that these sequences probably can't be patented in the first place - and even if they can, they shouldn't be. The plan would undercut patent protection for those who labor long and hard at the real task of elucidating the function of the proteins encoded by the genes, thereby driving industry away from developing inventions based on that work.

  5. BioenergizeME Virtual Science Fair: Science & Technology Sustainable...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Science & Technology Sustainable Transportation Fuels BioenergizeME Virtual Science Fair: Science & Technology Sustainable Transportation Fuels BioenergizeME Virtual Science Fair: ...

  6. Whose genome is it, anyway?

    SciTech Connect (OSTI)

    Marshall, E.

    1996-09-27

    The genome program has issued guidelines to ensure that sequencing is done on DNA from diverse sources who have given informed consent and are anonymous. Most current sources don`t meet those criteria. It may be the first question every nonexpert asks on learning about the Human Genome Project: Whose genome are we studying, anyway? It sounds naive, says one government scientist-so naive, in fact, that {open_quotes}we chuckle as we explain that we aren`t sequencing anyone`s genome in particular; we`re sequencing a representative genome{close_quotes} made up of a mosaic of DNA from a variety of anonymous sources. And Bruce Birren, a clone-maker now at the Massachusetts Institute of Technology`s (MIT`s) Whitehead Center for Genome Research says: {open_quotes}We spent many years pooh-poohing the question{close_quotes} of whose genome would be stored in the database. But now that labs have begun working on large stretches of human DNA-aiming to identify all 3 billion base pairs in the genetic code-the question no longer seems to laughable. To the distress of program managers in Bethesda, Maryland, the initial sources of DNA are not as diverse or as anonymous as they had assumed.

  7. The genome of Eucalyptus grandis

    SciTech Connect (OSTI)

    Myburg, Alexander A; Grattapaglia, Dario; Tuskan, Gerald A; Yang, Xiaohan; Priya, Ranjan; Tschaplinski, Timothy J; Ye, Chuyu; Li, Ting

    2014-01-01

    Eucalypts are the world s most widely planted hardwood trees. Their broad adaptability, rich species diversity, fast growth and superior multipurpose wood, have made them a global renewable resource of fiber and energy that mitigates human pressures on natural forests. We sequenced and assembled >94% of the 640 Mbp genome of Eucalyptus grandis into its 11 chromosomes. A set of 36,376 protein coding genes were predicted revealing that 34% occur in tandem duplications, the largest proportion found thus far in any plant genome. Eucalypts also show the highest diversity of genes for plant specialized metabolism that act as chemical defence against biotic agents and provide unique pharmaceutical oils. Resequencing of a set of inbred tree genomes revealed regions of strongly conserved heterozygosity, likely hotspots of inbreeding depression. The resequenced genome of the sister species E. globulus underscored the high inter-specific genome colinearity despite substantial genome size variation in the genus. The genome of E. grandis is the first reference for the early diverging Rosid order Myrtales and is placed here basal to the Eurosids. This resource expands knowledge on the unique biology of large woody perennials and provides a powerful tool to accelerate comparative biology, breeding and biotechnology.

  8. Bradbury Science Museum

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Renewable energy is focus of New Science on Wheels programs offered by Bradbury Science Museum September 21, 2010 Los Alamos National Laboratory is taking science on the road to...

  9. BES Science Network Requirements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Network Requirements Report of the Basic Energy Sciences Network Requirements Workshop Conducted June 4-5, 2007 BES Science Network Requirements Workshop Basic Energy Sciences Program Office, DOE Office of Science Energy Sciences Network Washington, DC - June 4 and 5, 2007 ESnet is funded by the US Dept. of Energy, Office of Science, Advanced Scientific Computing Research (ASCR) program. Dan Hitchcock is the ESnet Program Manager. ESnet is operated by Lawrence Berkeley National Laboratory, which

  10. Basic Energy Sciences Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Basic Energy Sciences Reports Basic Energy Sciences Reports The list below of Basic Energy Sciences workshop reports addresses the status of some important research areas that can help identify research directions for a decades-to-century energy strategy. Basic Energy Sciences (BES) Workshop Reports The Energy Challenges Report: New Science for a Secure and Sustainable Energy Future This Basic Energy Sciences Advisory Committee (BESAC) report summarizes a 2008 study by the Subcommittee on Facing

  11. Materials Science and Technology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MST Materials Science and Technology Providing world-leading, innovative, and agile materials science and technology solutions for national security missions. MST is metallurgy. The Materials Science and Technology Division provides scientific and technical leadership in materials science and technology for Los Alamos National Laboratory. READ MORE MST is engineered materials. The Materials Science and Technology Division provides scientific and technical leadership in materials science and

  12. Earth, Space Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Earth, Space Sciences /science-innovation/_assets/images/icon-science.jpg Earth, Space Sciences National security depends on science and technology. The United States relies on Los Alamos National Laboratory for the best of both. No place on Earth pursues a broader array of world-class scientific endeavors. Climate, Ocean and Sea Ice Modeling (COSIM)┬╗ Earth and Environmental Sciences Division┬╗ Intelligence and Space Research┬╗ Earth Read caption + A team of scientists is working to understand

  13. Science & Engineering Capabilities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Capabilities /science-innovation/_assets/images/icon-science.jpg Science & Engineering Capabilities These capabilities are our science and engineering at work for the national security interest in areas from global climate to cyber security, from nonproliferation to new materials, from clean energy solutions to supercomputing. Accelerators, Electrodynamics┬╗ Energy┬╗ Materials Science┬╗ Bioscience: Bioenergy, Biosecurity, and Health┬╗ Engineering┬╗ National Security, Weapons Science┬╗

  14. Human genome. 1993 Program report

    SciTech Connect (OSTI)

    Not Available

    1994-03-01

    The purpose of this report is to update the Human Genome 1991-92 Program Report and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes.

  15. Challenges in Whole-Genome Annotation of Pyrosequenced Eukaryotic Genomes

    SciTech Connect (OSTI)

    Kuo, Alan; Grigoriev, Igor

    2009-04-17

    Pyrosequencing technologies such as 454/Roche and Solexa/Illumina vastly lower the cost of nucleotide sequencing compared to the traditional Sanger method, and thus promise to greatly expand the number of sequenced eukaryotic genomes. However, the new technologies also bring new challenges such as shorter reads and new kinds and higher rates of sequencing errors, which complicate genome assembly and gene prediction. At JGI we are deploying 454 technology for the sequencing and assembly of ever-larger eukaryotic genomes. Here we describe our first whole-genome annotation of a purely 454-sequenced fungal genome that is larger than a yeast (>30 Mbp). The pezizomycotine (filamentous ascomycote) Aspergillus carbonarius belongs to the Aspergillus section Nigri species complex, members of which are significant as platforms for bioenergy and bioindustrial technology, as members of soil microbial communities and players in the global carbon cycle, and as agricultural toxigens. Application of a modified version of the standard JGI Annotation Pipeline has so far predicted ~;;10k genes. ~;;12percent of these preliminary annotations suffer a potential frameshift error, which is somewhat higher than the ~;;9percent rate in the Sanger-sequenced and conventionally assembled and annotated genome of fellow Aspergillus section Nigri member A. niger. Also,>90percent of A. niger genes have potential homologs in the A. carbonarius preliminary annotation. Weconclude, and with further annotation and comparative analysis expect to confirm, that 454 sequencing strategies provide a promising substrate for annotation of modestly sized eukaryotic genomes. We will also present results of annotation of a number of other pyrosequenced fungal genomes of bioenergy interest.

  16. Science Serving Sustainability

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Goal 8: Science Serving Sustainability LANL takes opportunities to engage the ... ENVIRONMENTAL SUSTAINABILITY GOALS at LANL Community involvement: Andy Erickson and Duncan ...

  17. Semiconductor Science and Technology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    world ssls.sandia.gov Initiates decades-long investment into compound semiconductor science and technology, eventually establishing its Center for Compound Semiconductor Science...

  18. Science and Innovation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Faces of Science The people behind our science Radical Supercomputing Extreme speeds, big data, powerful simulations 70 Years of Innovation Addressing the nation's most complex...

  19. Fusion Energy Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fusion Energy Sciences Fusion Energy Sciences Expanding the fundamental understanding of matter at very high temperatures and densities and to build the scientific foundation ...

  20. Sandia Energy - Computational Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Computational Science Home Energy Research Advanced Scientific Computing Research (ASCR) Computational Science Computational Sciencecwdd2015-03-26T13:35:2...

  1. Nuclear Science Series: Radiochemistry

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Radiochemistry Nuclear Science Series: Radiochemistry These volumes are publicly ... working under the Committee on Nuclear Science within the National Academy of ...

  2. Stewardship Science Academic Alliances

    National Nuclear Security Administration (NNSA)

    0%2A en NNSA's holds Stewardship Science Academic Programs Annual Review Symposium http:nnsa.energy.govblognnsas-holds-stewardship-science-academic-programs-annual-review-symp...

  3. Science and Technology Day

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science and Technology Day Science and Technology Day February 24, 2015 Tuesday, Feb. 24 Berkeley Lab Building 50 Auditorium Attendance is open to anyone. Remote streaming is...

  4. Science Briefs - 2012

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    newsroomassetsimagesnewsroom-icon.jpg Science Briefs - 2012 Read in detail about specific Los Alamos science achievements, and the honors our scientists are accruing. Los...

  5. Science Briefs - 2014

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    newsroomassetsimagesnewsroom-icon.jpg Science Briefs - 2014 Read in detail about specific Los Alamos science achievements, and the honors our scientists are accruing....

  6. ARM - TWP Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science TWP Related Links Facilities and Instruments Manus Island Nauru Island Darwin, AUS ES&H Guidance Statement Operations Science Field Campaigns Year of Tropical...

  7. Mapping our genes: The genome projects: How big, how fast

    SciTech Connect (OSTI)

    none,

    1988-04-01

    For the past 2 years, scientific and technical journals in biology and medicine have extensively covered a debate about whether and how to determine the function and order of human genes on human chromosomes and when to determine the sequence of molecular building blocks that comprise DNA in those chromosomes. In 1987, these issues rose to become part of the public agenda. The debate involves science, technology, and politics. Congress is responsible for /open quotes/writing the rules/close quotes/ of what various federal agencies do and for funding their work. This report surveys the points made so far in the debate, focusing on those that most directly influence the policy options facing the US Congress. Congressional interest focused on how to assess the rationales for conducting human genome projects, how to fund human genome projects (at what level and through which mechanisms), how to coordinate the scientific and technical programs of the several federal agencies and private interests already supporting various genome projects, and how to strike a balance regarding the impact of genome projects on international scientific cooperation and international economic competition in biotechnology. OTA prepared this report with the assistance of several hundred experts throughout the world. 342 refs., 26 figs., 11 tabs.

  8. Mapping Our Genes: The Genome Projects: How Big, How Fast

    DOE R&D Accomplishments [OSTI]

    1988-04-01

    For the past 2 years, scientific and technical journals in biology and medicine have extensively covered a debate about whether and how to determine the function and order of human genes on human chromosomes and when to determine the sequence of molecular building blocks that comprise DNA in those chromosomes. In 1987, these issues rose to become part of the public agenda. The debate involves science, technology, and politics. Congress is responsible for ´┐Żwriting the rules´┐Ż of what various federal agencies do and for funding their work. This report surveys the points made so far in the debate, focusing on those that most directly influence the policy options facing the US Congress. Congressional interest focused on how to assess the rationales for conducting human genome projects, how to fund human genome projects (at what level and through which mechanisms), how to coordinate the scientific and technical programs of the several federal agencies and private interests already supporting various genome projects, and how to strike a balance regarding the impact of genome projects on international scientific cooperation and international economic competition in biotechnology. The Office of Technology Assessment (OTA) prepared this report with the assistance of several hundred experts throughout the world.

  9. Fundamental Science Applications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fundamental Science Applications Fundamental Science Applications Supporing research to understand, predict and ultimately control matter and energy at the electronic, atomic, and molecular levels. Contact thumbnail of Business Development Executive Don Hickmott Business Development Executive Richard P. Feynman Center for Innovation (505) 667-8753 Email Fundamental Science Applications The DOE Basic Energy Science (BES) program supports research to understand, predict and ultimately control

  10. Solar Energy Science Projects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Projects Curriculum: Solar Power -(thermodynamics, lightelectromagnetic, radiation, energy transformation, conductionconvection, seasons, trigonometry) Grade Level: ...

  11. Science and Suds

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science and Suds Science and Suds WHEN: Jul 18, 2015 12:00 PM - 4:00 PM WHERE: Los Alamos ScienceFest Beer Garden Ashley Pond, Downtown Los Alamos, NM CONTACT: Jessica Privette 505 667-0375 CATEGORY: Bradbury INTERNAL: Calendar Login Science and Suds - Social Event Event Description Conversations with real scientists at the Los Alamos ScienceFest Beer Garden SCIENCE & SUDS Stop by the museum's tent in the beer garden at Ashley Pond during Los Alamos ScienceFest to visit with a scientist

  12. Home | ScienceCinema

    Broader source: All U.S. Department of Energy (DOE) Office Webpages

    ScienceCinema Home About ScienceCinema FAQ Site Map Contact Us DOE Home ┬╗ ScienceCinema Navigation ScienceCinema Home About ScienceCinema FAQ Site Map Contact Us OSTI Home DOE Home ScienceCinema Database Searchable Videos Showcasing DOE Research Search DOE ScienceCinema for Multimedia Find + Fielded Search Audio Search ├Ś Fielded Search Title: Description/Abstract: Bibliographic Data: Author/Speaker: Name Name ORCID Media Type: All Audio Video Subject: Identifier Numbers: Media Source: All DOE

  13. The mouse genome informatics and the mouse genome database

    SciTech Connect (OSTI)

    Maltais, L.J.; Blackburn, R.E.; Bradt, D.W.

    1994-09-01

    The Mouse Genome Database (MGD) is a centralized, comprehensive database of the mouse genome that includes genetic mapping data, comparative mapping data, gene descriptions, mutant phenotype descriptions, strains and allelic polymorphism data, inbred strain characteristics, physical mapping data, and molecular probes and clones data. Data in MGD are obtained from the published literature and by electronic transfer from laboratories working on large backcross panels of mice. MGD provides tools that enable the user to search the database, retrieve data, generate reports, analyze data, annotate records, and build genetic maps. The Encyclopedia of the Mouse Genome provides a graphic user interface to mouse genome data. It consists of software tools including: LinkMap, a graphic display of genetic linkage maps with the ability to magnify regions of high locus density: CytoMap, a graphic display of cytogenetic maps showing banded chromosomes with cytogenetic locations of genes and chromosomal aberrations; CATS, a catalog searching tool for text retrieval of mouse locus descriptions. These software tools provide access to the following data sets: Chromosome Committee Reports, MIT Genome Center data, GBASE reports, Mouse Locus Catalog (MLC), and Mouse Cytogenetic Mapping Data. The MGD is available to the scientific community through the World Wide Web (WWW) and Gopher. In addition GBASE can be accessed via the Internet.

  14. Manhattan Project: Science

    Office of Scientific and Technical Information (OSTI)

    Science In the Laboratory Particle Accelerators and Other Technologies The Atom and Atomic Structure Nuclear Physics Bomb Design and Components Radioactivity Science and technology of the Manhattan Project Science PLEASE NOTE: The Science pages are not yet available. Links to the pages listed below and to the left will be activated as content is developed. Select topics relating to the science and technology of the Manhattan Project have been grouped into the categories listed to the left. A

  15. Committee on Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science SHERWOOD BOEHLERT, CHAIRMAN Ralph M. Hall, Texas, Ranking Democrat www.house.gov/science October 9, 2001 Press Contacts: Heidi Mohlman Tringe (Heidi.Tringe@mail.house.gov) Jeff Donald (Jeffrey.Donald@mail.house.gov) (202)225-4275 BOEHLERT, GRUCCI TO URGE SWIFT CONFIRMATION OF SCIENCE ADVISOR WASHINGTON, DC -- Today, House Science Committee Chairman Sherwood Boehlert (R-NY23) and Committee member Felix J. Grucci (R-NY1) will call for the swift confirmation of Presidential Science Advisor

  16. BER Science Network Requirements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    BER Science Network Requirements Report of the Biological and Environmental Research Network Requirements Workshop Conducted July 26 and 27, 2007 BER Science Network Requirements Workshop Biological and Environmental Research Program Office, DOE Office of Science Energy Sciences Network Bethesda, MD - July 26 and 27, 2007 ESnet is funded by the US Dept. of Energy, Office of Science, Advanced Scientific Computing Research (ASCR) program. Dan Hitchcock is the ESnet Program Manager. ESnet is

  17. National Security, Weapons Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    National Security, Weapons Science /science-innovation/_assets/images/icon-science.jpg National Security, Weapons Science National security depends on science and technology. The United States relies on Los Alamos National Laboratory for the best of both. No place on Earth pursues a broader array of world-class scientific endeavors. CoMuEx┬╗ Explosives Center┬╗ Dual-Axis Radiographic Hydrodynamic Test Facility (DARHT) The Dual-Axis Radiographic Hydrodynamic Test Facility at LANL is part of the

  18. Science Requirements Process

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Requirements Reviews Network Requirements Reviews Requirements Review Reports Case Studies News & Publications ESnet News Publications and Presentations Galleries ESnet Awards and Honors Blog ESnet Live Home ┬╗ Science Engagement ┬╗ Science Requirements Reviews Science Engagement Move your data Programs & Workshops Science Requirements Reviews Network Requirements Reviews Requirements Review Reports Case Studies Contact Us Technical Assistance: 1 800-33-ESnet (Inside US) 1

  19. GOLD: The Genomes Online Database

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kyrpides, Nikos; Liolios, Dinos; Chen, Amy; Tavernarakis, Nektarios; Hugenholtz, Philip; Markowitz, Victor; Bernal, Alex

    Since its inception in 1997, GOLD has continuously monitored genome sequencing projects worldwide and has provided the community with a unique centralized resource that integrates diverse information related to Archaea, Bacteria, Eukaryotic and more recently Metagenomic sequencing projects. As of September 2007, GOLD recorded 639 completed genome projects. These projects have their complete sequence deposited into the public archival sequence databases such as GenBank EMBL,and DDBJ. From the total of 639 complete and published genome projects as of 9/2007, 527 were bacterial, 47 were archaeal and 65 were eukaryotic. In addition to the complete projects, there were 2158 ongoing sequencing projects. 1328 of those were bacterial, 59 archaeal and 771 eukaryotic projects. Two types of metadata are provided by GOLD: (i) project metadata and (ii) organism/environment metadata. GOLD CARD pages for every project are available from the link of every GOLD_STAMP ID. The information in every one of these pages is organized into three tables: (a) Organism information, (b) Genome project information and (c) External links. [The Genomes On Line Database (GOLD) in 2007: Status of genomic and metagenomic projects and their associated metadata, Konstantinos Liolios, Konstantinos Mavromatis, Nektarios Tavernarakis and Nikos C. Kyrpides, Nucleic Acids Research Advance Access published online on November 2, 2007, Nucleic Acids Research, doi:10.1093/nar/gkm884]

    The basic tables in the GOLD database that can be browsed or searched include the following information:

    • Gold Stamp ID
    • Organism name
    • Domain
    • Links to information sources
    • Size and link to a map, when available
    • Chromosome number, Plas number, and GC content
    • A link for downloading the actual genome data
    • Institution that did the sequencing
    • Funding source
    • Database where information resides
    • Publication status and information

    (Specialized Interface)

  20. Bradbury Science Museum - Science on Wheels

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    To stimulate interest in and enthusiasm for science, technology, engineering and mathematics and promote public understanding and appreciation of Los Alamos National Laboratory...

  1. The Genomes and Metagenomes (GEM) Catalogue (first presentation) and The ISA-GCDML Workshop (second presentation) (GSC8 Meeting)

    ScienceCinema (OSTI)

    Field, Dawn [NERC Centre for Ecology and Hydrology]; Sansone, Susanna [EBI

    2011-04-29

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding ''Research Coordination Network'' from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Dawn Field of the NERC Centre for Ecology & Hydrology briefly introduces the GEM Catalogue, followed by Susanna Sansone of the European Bioinformatics Institute who talks about the ISA-GCDML workshop at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 9, 2009.

  2. Expanding genomics of mycorrhizal symbiosis

    SciTech Connect (OSTI)

    Kuo, Alan; Kohler, Annegret; Martin, Francis M.; Grigoriev, Igor V.

    2014-11-04

    The mycorrhizal symbiosis between soil fungi and plant roots is a ubiquitous mutualism that plays key roles in plant nutrition, soil health, and carbon cycling. The symbiosis evolved repeatedly and independently as multiple morphotypes [e.g., arbuscular mycorrhizae (AM), ectomycorrhizal (ECM)] in multiple fungal clades (e.g., phyla Glomeromycota, Ascomycota, Basidiomycota). The accessibility and cultivability of many mycorrhizal partners make them ideal models for symbiosis studies. Alongside molecular, physiological, and ecological investigations, sequencing led to the first three mycorrhizal fungal genomes, representing two morphotypes and three phyla. The genome of the ECM basidiomycete Laccaria bicolor showed that the mycorrhizal lifestyle can evolve through loss of plant cell wall-degrading enzymes (PCWDEs) and expansion of lineage-specific gene families such as short secreted protein (SSP) effectors. The genome of the ECM ascomycete Tuber melanosporum showed that the ECM type can evolve without expansion of families as in Laccaria, and thus a different set of symbiosis genes. The genome of the AM glomeromycete Rhizophagus irregularis showed that despite enormous phylogenetic distance and morphological difference from the other two fungi, symbiosis can involve similar solutions as symbiosis-induced SSPs and loss of PCWDEs. The three genomes provide a solid base for addressing fundamental questions about the nature and role of a vital mutualism.

  3. Expanding genomics of mycorrhizal symbiosis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kuo, Alan; Kohler, Annegret; Martin, Francis M.; Grigoriev, Igor V.

    2014-11-04

    The mycorrhizal symbiosis between soil fungi and plant roots is a ubiquitous mutualism that plays key roles in plant nutrition, soil health, and carbon cycling. The symbiosis evolved repeatedly and independently as multiple morphotypes [e.g., arbuscular mycorrhizae (AM), ectomycorrhizal (ECM)] in multiple fungal clades (e.g., phyla Glomeromycota, Ascomycota, Basidiomycota). The accessibility and cultivability of many mycorrhizal partners make them ideal models for symbiosis studies. Alongside molecular, physiological, and ecological investigations, sequencing led to the first three mycorrhizal fungal genomes, representing two morphotypes and three phyla. The genome of the ECM basidiomycete Laccaria bicolor showed that the mycorrhizal lifestyle can evolvemore┬á┬╗ through loss of plant cell wall-degrading enzymes (PCWDEs) and expansion of lineage-specific gene families such as short secreted protein (SSP) effectors. The genome of the ECM ascomycete Tuber melanosporum showed that the ECM type can evolve without expansion of families as in Laccaria, and thus a different set of symbiosis genes. The genome of the AM glomeromycete Rhizophagus irregularis showed that despite enormous phylogenetic distance and morphological difference from the other two fungi, symbiosis can involve similar solutions as symbiosis-induced SSPs and loss of PCWDEs. The three genomes provide a solid base for addressing fundamental questions about the nature and role of a vital mutualism.┬ź┬áless

  4. Enhancer Identification through Comparative Genomics

    SciTech Connect (OSTI)

    Visel, Axel; Bristow, James; Pennacchio, Len A.

    2006-10-01

    With the availability of genomic sequence from numerousvertebrates, a paradigm shift has occurred in the identification ofdistant-acting gene regulatory elements. In contrast to traditionalgene-centric studies in which investigators randomly scanned genomicfragments that flank genes of interest in functional assays, the modernapproach begins electronically with publicly available comparativesequence datasets that provide investigators with prioritized lists ofputative functional sequences based on their evolutionary conservation.However, although a large number of tools and resources are nowavailable, application of comparative genomic approaches remains far fromtrivial. In particular, it requires users to dynamically consider thespecies and methods for comparison depending on the specific biologicalquestion under investigation. While there is currently no single generalrule to this end, it is clear that when applied appropriately,comparative genomic approaches exponentially increase our power ingenerating biological hypotheses for subsequent experimentaltesting.

  5. Physical Sciences 2007 Science & Technology Highlights

    SciTech Connect (OSTI)

    Hazi, A U

    2008-04-07

    The Physical Sciences Directorate applies frontier physics and technology to grand challenges in national security. Our highly integrated and multidisciplinary research program involves collaborations throughout Lawrence Livermore National Laboratory, the National Nuclear Security Administration, the Department of Energy, and with academic and industrial partners. The Directorate has a budget of approximately $150 million, and a staff of approximately 350 employees. Our scientists provide expertise in condensed matter and high-pressure physics, plasma physics, high-energy-density science, fusion energy science and technology, nuclear and particle physics, accelerator physics, radiation detection, optical science, biotechnology, and astrophysics. This document highlights the outstanding research and development activities in the Physical Sciences Directorate that made news in 2007. It also summarizes the awards and recognition received by members of the Directorate in 2007.

  6. Strategies and tools for whole genome alignments

    SciTech Connect (OSTI)

    Couronne, Olivier; Poliakov, Alexander; Bray, Nicolas; Ishkhanov,Tigran; Ryaboy, Dmitriy; Rubin, Edward; Pachter, Lior; Dubchak, Inna

    2002-11-25

    The availability of the assembled mouse genome makespossible, for the first time, an alignment and comparison of two largevertebrate genomes. We have investigated different strategies ofalignment for the subsequent analysis of conservation of genomes that areeffective for different quality assemblies. These strategies were appliedto the comparison of the working draft of the human genome with the MouseGenome Sequencing Consortium assembly, as well as other intermediatemouse assemblies. Our methods are fast and the resulting alignmentsexhibit a high degree of sensitivity, covering more than 90 percent ofknown coding exons in the human genome. We have obtained such coveragewhile preserving specificity. With a view towards the end user, we havedeveloped a suite of tools and websites for automatically aligning, andsubsequently browsing and working with whole genome comparisons. Wedescribe the use of these tools to identify conserved non-coding regionsbetween the human and mouse genomes, some of which have not beenidentified by other methods.

  7. Science On Tap

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science On Tap Science On Tap WHEN: Mar 19, 2015 5:30 PM - 7:00 PM WHERE: UnQuarked Wine Room 145 Central Park Square, Los Alamos, NM 87544 CONTACT: Jessica Privette 505 667-0375...

  8. Science On Tap

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science On Tap Science On Tap WHEN: Nov 19, 2015 5:30 PM - 7:00 PM WHERE: UnQuarked Wine Room 145 Central Park Square, Los Alamos, NM 87544 USA SPEAKER: Ray Newell, Quantum...

  9. Science on Tap

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    January Science on Tap Science on Tap WHEN: Jan 15, 2015 5:30 PM - 7:00 PM WHERE: UnQuarked The Wine Room, 145 Central Park Square, Los Alamos CONTACT: Jessica Privette 505...

  10. National Science Bowl

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy (DOE) National Science Bowl is a nationwide academic competition that tests students' knowledge in all areas of science. High school and middle school students are...

  11. Science of Signatures - Past Programs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Institute Science of Signatures - Past Programs Science of Signatures Program Science of Signatures - Past Programs Contact Institute Director Charles Farrar (505) 665-0860...

  12. Science of Signatures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science of Signatures Science of Signatures (SoS) The Lab's four Science Pillars harness our scientific capabilities for national security solutions. Contacts Pillar Champion Nancy Sauer Email Pillar Contact Gene Peterson Email Science of Signatures (SoS) Overview In its broadest and simplest sense, a "signature" is any information that is unique, recognizable, and useful. A handwritten mark as a means of demonstrating authenticity is a familiar example, as is the pattern variation

  13. Weaving Community and Science

    Broader source: Energy.gov [DOE]

    Weaving Community and Science: Former Summer Intern Is Investigating Plant Uptake of Contaminants on Disposal Cell Covers

  14. ORISE: Science Education Events

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Education Events Science Education Events Recognizing that vast improvements in science, technology, engineering and math are key to innovation and economic growth, the Oak Ridge Institute for Science and Education (ORISE) manages high-profile local and national education and research initiatives. For example, scholarly competitions, summer education workshops and teacher professional development programs create excitement and inspire educators and students to pursue interests in

  15. Frontiers in Science Archive

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Frontiers in Science Lectures ┬╗ Frontiers in Science Archive Frontiers in Science Archive x LInda Anderman (505) 665-9196 Email The Frontiers in Science lecture series are a public service of the Los Alamos National Laboratory Fellows. Fellows are appointed by the Laboratory Director in recognition of sustained outstanding contributions and exceptional promise for continued professional achievement. All lectures are open to the public and free of charge. PAST LECTURES 2015 August Beyond Pluto:

  16. Fusion Energy Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fusion Energy Sciences Fusion Energy Sciences Expanding the fundamental understanding of matter at very high temperatures and densities and to build the scientific foundation needed to develop a fusion energy source. Get Expertise Don Rej (505) 665-1883 Email Building the scientific foundation needed to develop a fusion energy source The mission of the DOE Office of Science's Fusion Energy Sciences (FES) program is to expand the fundamental understanding of matter at very high temperatures and

  17. Basic Energy Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Basic Energy Sciences Basic Energy Sciences Supporing research to understand, predict and ultimately control matter and energy at the electronic, atomic, and molecular levels. Get Expertise Toni Taylor (505) 665-0030 Email Quanxi Jia (505) 667-2716 Email David Morris (505) 665-6487 Email Claudia Mora (505) 665-7832 Email Research fosters fundamental scientific discoveries to meet energy, environmental, and national security challenges The DOE Office of Science's Basic Energy Sciences program

  18. ARM - Science Questions

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Questions Related Links MC3E Home News News & Press MC3E Backgrounder (PDF, 1.61MB) SGP Images ARM flickr site Field Blog ARM Data Discovery Browse Data Deployment Operations Measurements Science Plan (PDF, 3.85 MB) Featured Data Plots SGP Data Plots (all) Experiment Planning Steering Committee Science Questions MC3E Proposal Abstract and Related Campaigns Meetings Cloud Life Cycle Working Group Contacts Michael Jensen, Lead Scientist Science Questions This experiment seeks to use a

  19. Judicial Science School

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Judicial Science School Judicial Science School The goal of Los Alamos Judicial Science School is to provide judges with knowledge and experience that will enhance their ability to evaluate whether scientific arguments meet the threshold requirements of admissibility. Contacts NSEC Director David L. Clark (505) 665-0983 Email Engineering Institute Director Charles Farrar (505) 665-0860 Email Executive Administrator Ellie Vigil (505) 667-2818 Email Judicial Science School Developed through close

  20. NERSC Science Engagements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NERSC Science Engagements NERSC Science Engagements At NERSC, science comes first. NERSC systems and services are designed to enable and support cutting-edge research within the U.S. Deparment of Energy's Office of Science. NERSC engages with the scientific community in many ways both formally and informally. Among the more formal mechanisms are the NERSC Requirements Reviews, which have now become the DOE Exascale Requirements Reviews jointly with the Argonne and Oak Ridge Leadership Computing

  1. Bradbury Science Museum

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bradbury Science Museum Bradbury Science Museum Providing a window into the history of LANL, its national security mission, and the broad range of exciting science and technology research programs undertaken to improve our nation's future. June 13, 2012 Young visitor shakes the hand of an Oppenheimer statue J. Robert Oppenheimer is a welcoming presence in the Bradbury Science Museum's History Gallery. Visitors go on to explore the Laboratory's beginnings during the Manhattan Project through

  2. ARM - AMF Science Questions

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AzoresAMF Science Questions Azores Deployment AMF Home Graciosa Island Home Data Plots and Baseline Instruments Satellite Retrievals Experiment Planning CAP-MBL Proposal Abstract and Related Campaigns Science Questions Science Plan (PDF, 4.4M) Rob Wood Website Outreach Backgrounders English Version (PDF, 363K) Portuguese Version (PDF, 327K) AMF Posters, 2009 English Version Portuguese Version Education Flyers English Version Portuguese Version News Campaign Images AMF Science Questions Which

  3. GDB - Human Genome Database final report

    SciTech Connect (OSTI)

    Talbot, C. Conover, Jr.

    2002-01-08

    This is the DOE final report for the GDB, Human Genome Database, project at the Johns Hopkins University.

  4. Genome informatics: Requirements and challenges

    SciTech Connect (OSTI)

    Robbins, R.J.

    1993-12-31

    Informatics of some kind will play a role in every aspect of the Human Genome Project (HGP); data acquisition, data analysis, data exchange, data publication, and data visualization. What are the real requirements and challenges? The primary requirement is clear thinking and the main challenge is design. If good design is lacking, the price will be failure of genome informatics and ultimately failure of the genome project itself. Scientists need good designs to deliver the tools necessary for acquiring and analyzing DNA sequences. As these tools become more efficient, they will need new tools for comparative genomic analyses. To make the tools work, the scientists will need to address and solve nomenclature issues that are essential, if also tedious. They must devise systems that will scale gracefully with the increasing flow of data. The scientists must be able to move data easily from one system to another, with no loss of content. As scientists, they will have failed in their responsibility to share results, should repeating experiments ever become preferable to searching the literature. Their databases must become a new kind of scientific literature and the scientists must develop ways to make electronic data publishing as routine as traditional journal publishing. Ultimately, they must build systems so advanced that they are virtually invisible. In summary, the HGP can be considered the most ambitious, most audacious information-management project ever undertaken. In the HGP, computers will not merely serve as tools for cataloging existing knowledge. Rather, they will serve as instruments, helping to create new knowledge by changing the way the scientists see the biological world. Computers will allow them to see genomes, just as radio telescopes let them see quasars and electron microscopes let them see viruses.

  5. Science DMZ Implemented at CU Boulder

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CU Science Engagement Move your data Programs & Workshops Science Requirements Reviews Case Studies OSCARS Case Studies Science DMZ Case Studies Science DMZ @ UF Science DMZ @ CU...

  6. Science DMZ National Oceanic and Atmospheric Administration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NOAA Science Engagement Move your data Programs & Workshops Science Requirements Reviews Case Studies OSCARS Case Studies Science DMZ Case Studies Science DMZ @ UF Science DMZ @ CU...

  7. BES Science Network Requirements

    SciTech Connect (OSTI)

    Biocca, Alan; Carlson, Rich; Chen, Jackie; Cotter, Steve; Tierney, Brian; Dattoria, Vince; Davenport, Jim; Gaenko, Alexander; Kent, Paul; Lamm, Monica; Miller, Stephen; Mundy, Chris; Ndousse, Thomas; Pederson, Mark; Perazzo, Amedeo; Popescu, Razvan; Rouson, Damian; Sekine, Yukiko; Sumpter, Bobby; Dart, Eli; Wang, Cai-Zhuang -Z; Whitelam, Steve; Zurawski, Jason

    2011-02-01

    The Energy Sciences Network (ESnet) is the primary provider of network connectivityfor the US Department of Energy Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. In support of the Office ofScience programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years.

  8. Middle School Science Bowl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2015 ┬╗ February ┬╗ Middle School Science Bowl Middle School Science Bowl WHEN: Feb 28, 2015 8:00 AM - 4:00 PM WHERE: Highland High School 4700 Coal Ave SE, Albuquerque, NM CATEGORY: Community INTERNAL: Calendar Login Event Description The Science Bowl is a Jeopardy-like event for high school and middle school students who have a strong interest in mathematics and science. The Science Bowl competition is in the form of a round robin in the morning and double elimination after lunch. Teams

  9. The ecoresponsive genome of Daphnia pulex

    SciTech Connect (OSTI)

    Colbourne, John K.; Pfrender, Michael E.; Gilbert, Donald; Thomas, W. Kelley; Tucker, Abraham; Oakley, Todd H.; Tokishita, Shinichi; Aerts, Andrea; Arnold, Georg J.; Basu, Malay Kumar; Bauer, Darren J.; Caceres, Carla E.; Carmel, Liran; Casola, Claudio; Choi, Jeong-Hyeon; Detter, John C.; Dong, Qunfeng; Dusheyko, Serge; Eads, Brian D.; Frohlich, Thomas; Geiler-Samerotte, Kerry A.; Gerlach, Daniel; Hatcher, Phil; Jogdeo, Sanjuro; Krijgsveld, Jeroen; Kriventseva, Evgenia V; KŘltz, Dietmar; Laforsch, Christian; Lindquist, Erika; Lopez, Jacqueline; Manak, Robert; Muller, Jean; Pangilinan, Jasmyn; Patwardhan, Rupali P.; Pitluck, Samuel; Pritham, Ellen J.; Rechtsteiner, Andreas; Rho, Mina; Rogozin, Igor B.; Sakarya, Onur; Salamov, Asaf; Schaack, Sarah; Shapiro, Harris; Shiga, Yasuhiro; Skalitzky, Courtney; Smith, Zachary; Souvorov, Alexander; Sung, Way; Tang, Zuojian; Tsuchiya, Dai; Tu, Hank; Vos, Harmjan; Wang, Mei; Wolf, Yuri I.; Yamagata, Hideo; Yamada, Takuji; Ye, Yuzhen; Shaw, Joseph R.; Andrews, Justen; Crease, Teresa J.; Tang, Haixu; Lucas, Susan M.; Robertson, Hugh M.; Bork, Peer; Koonin, Eugene V.; Zdobnov, Evgeny M.; Grigoriev, Igor V.; Lynch, Michael; Boore, Jeffrey L.

    2011-02-04

    This document provides supporting material related to the sequencing of the ecoresponsive genome of Daphnia pulex. This material includes information on materials and methods and supporting text, as well as supplemental figures, tables, and references. The coverage of materials and methods addresses genome sequence, assembly, and mapping to chromosomes, gene inventory, attributes of a compact genome, the origin and preservation of Daphnia pulex genes, implications of Daphnia's genome structure, evolutionary diversification of duplicated genes, functional significance of expanded gene families, and ecoresponsive genes. Supporting text covers chromosome studies, gene homology among Daphnia genomes, micro-RNA and transposable elements and the 46 Daphnia pulex opsins. 36 figures, 50 tables, 183 references.

  10. Interfacial and Surface Science | Materials Science | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Interfacial and Surface Science Image of irregular-outlined, light-colored shapes on a dark background. Represents a tapping-mode atomic force microscope image of gallium phosphide on silicon. NREL researchers have developed an integrated set of experimental capabilities to address a broad range of fundamental and applied issues in surface and interfacial science that are critical for advancing sustainable-energy technologies. Surface and interface phenomena often control the opto-electronic,

  11. Materials Science Research | Materials Science | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Research For photovoltaics and other energy applications, NREL's primary research in materials science includes the following core competencies. A photo of laser light rays going in various directions atop a corrugated metal substrate Materials Physics Through materials growth and characterization, we seek to understand and control fundamental electronic and optical processes in semiconductors. An image of multiple, interconnecting red and blue particles Electronic Structure Theory We

  12. Synchrotron Radiation in Polymer Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Synchrotron Radiation in Polymer Science Synchrotron Radiation in Polymer Science March 30-April 2, 2012; San Francisco

  13. Synchrotron Radiation in Polymer Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Synchrotron Radiation in Polymer Science Synchrotron Radiation in Polymer Science March 30-April 2, 2012; San Francisco...

  14. Genome Improvement at JGI-HAGSC

    SciTech Connect (OSTI)

    Grimwood, Jane; Schmutz, Jeremy J.; Myers, Richard M.

    2012-03-03

    Since the completion of the sequencing of the human genome, the Joint Genome Institute (JGI) has rapidly expanded its scientific goals in several DOE mission-relevant areas. At the JGI-HAGSC, we have kept pace with this rapid expansion of projects with our focus on assessing, assembling, improving and finishing eukaryotic whole genome shotgun (WGS) projects for which the shotgun sequence is generated at the Production Genomic Facility (JGI-PGF). We follow this by combining the draft WGS with genomic resources generated at JGI-HAGSC or in collaborator laboratories (including BAC end sequences, genetic maps and FLcDNA sequences) to produce an improved draft sequence. For eukaryotic genomes important to the DOE mission, we then add further information from directed experiments to produce reference genomic sequences that are publicly available for any scientific researcher. Also, we have continued our program for producing BAC-based finished sequence, both for adding information to JGI genome projects and for small BAC-based sequencing projects proposed through any of the JGI sequencing programs. We have now built our computational expertise in WGS assembly and analysis and have moved eukaryotic genome assembly from the JGI-PGF to JGI-HAGSC. We have concentrated our assembly development work on large plant genomes and complex fungal and algal genomes.

  15. Neutron and Nuclear Science News

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    News Recent news and events related to neutron and nuclear science at LANSCE. Neutron and Nuclear Science News Nuclear and Materials Science Research at LANSCE Nuclear science observations and opportunities at the Los Alamos Neutron Science Center Links Neutron and Nuclear Science News Media Links Profiles Events at LANSCE LAPIS (LANSCE Proposal Intake System

  16. Insights from Human/Mouse genome comparisons

    SciTech Connect (OSTI)

    Pennacchio, Len A.

    2003-03-30

    Large-scale public genomic sequencing efforts have provided a wealth of vertebrate sequence data poised to provide insights into mammalian biology. These include deep genomic sequence coverage of human, mouse, rat, zebrafish, and two pufferfish (Fugu rubripes and Tetraodon nigroviridis) (Aparicio et al. 2002; Lander et al. 2001; Venter et al. 2001; Waterston et al. 2002). In addition, a high-priority has been placed on determining the genomic sequence of chimpanzee, dog, cow, frog, and chicken (Boguski 2002). While only recently available, whole genome sequence data have provided the unique opportunity to globally compare complete genome contents. Furthermore, the shared evolutionary ancestry of vertebrate species has allowed the development of comparative genomic approaches to identify ancient conserved sequences with functionality. Accordingly, this review focuses on the initial comparison of available mammalian genomes and describes various insights derived from such analysis.

  17. Structural Genomics of Protein Phosphatases

    SciTech Connect (OSTI)

    Almo,S.; Bonanno, J.; Sauder, J.; Emtage, S.; Dilorenzo, T.; Malashkevich, V.; Wasserman, S.; Swaminathan, S.; Eswaramoorthy, S.; et al

    2007-01-01

    The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

  18. 11th Annual Energy Department Joint Genome Institute Genomics of Energy &

    Energy Savers [EERE]

    Environment Meeting | Department of Energy 11th Annual Energy Department Joint Genome Institute Genomics of Energy & Environment Meeting 11th Annual Energy Department Joint Genome Institute Genomics of Energy & Environment Meeting March 21, 2016 9:00AM PDT to March 25, 2016 4:00PM PDT Marriott Hotel 2355 North Main Street Walnut Creek, California 94596 The 11th Annual Energy Department (DOE) Joint Genome Institute Genomics of Energy & Environment Meeting will be held March 21-25,

  19. Top Science of 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Multipronged HIV vaccine shows promise in monkeys /science-innovation/_assets/images/icon-science.jpg Top Science of 2013 Our strong interdisciplinary teaming and unique research facilities allow us to develop solutions to complex problems, and to support partners and collaborators, all with the goal of strengthening national security and making a safer world. lab worker Multipronged HIV vaccine shows promise in monkeys lab worker HIV constantly mutates into many different strains that

  20. Top Science of 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Liquid-scanning technology boosts airport security /science-innovation/_assets/images/icon-science.jpg Top Science of 2013 Our strong interdisciplinary teaming and unique research facilities allow us to develop solutions to complex problems, and to support partners and collaborators, all with the goal of strengthening national security and making a safer world. Liquid-scanning technology boosts airport security placeholder Uniquely combining Magnetic Resonance Imaging (MRI) and X-ray technology,

  1. Top Science of 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    RAPTOR telescope witnesses black hole birth /science-innovation/_assets/images/icon-science.jpg Top Science of 2013 Our strong interdisciplinary teaming and unique research facilities allow us to develop solutions to complex problems, and to support partners and collaborators, all with the goal of strengthening national security and making a safer world. RAPTOR telescope witnesses black hole birth placeholder The first "thinking telescope" RAPTOR found the birth of big black holes,

  2. Top Science of 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Space probes predict hazards to protect spacecraft /science-innovation/_assets/images/icon-science.jpg Top Science of 2013 Our strong interdisciplinary teaming and unique research facilities allow us to develop solutions to complex problems, and to support partners and collaborators, all with the goal of strengthening national security and making a safer world. Space probes predict hazards to protect spacecraft placeholder Researchers think they've solved a 50-year-old space mystery about how

  3. Biomolecular Science (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2012-04-01

    A brief fact sheet about NREL Photobiology and Biomolecular Science. The research goal of NREL's Biomolecular Science is to enable cost-competitive advanced lignocellulosic biofuels production by understanding the science critical for overcoming biomass recalcitrance and developing new product and product intermediate pathways. NREL's Photobiology focuses on understanding the capture of solar energy in photosynthetic systems and its use in converting carbon dioxide and water directly into hydrogen and advanced biofuels.

  4. Science | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12 GeV Upgrade Science A Schematic of the 12 GeV Upgrade The 12 GeV Upgrade will greatly expand the research capabilities of Jefferson Lab, adding a fourth experimental hall, upgrading existing halls and doubling the power of the lab's accelerator. Read more User Information Science Accelerator Magnets Magnets ready for installation at Jefferson Lab as part of the 12 GeV Upgrade project. Read more Experiment Research Science Jefferson Lab's Accelerator Tunnel Jefferson Lab's accelerator is

  5. Nuclear Materials Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    16 Nuclear Materials Science Our multidisciplinary expertise comprises the core actinide materials science and metallurgical capability within the nuclear weapons production and surveillance communities. Contact Us Group Leader David Pugmire (acting) Email Group Office (505) 667-4665 The evaluations performed by our group are essential for the nuclear weapons program as well as nuclear materials storage, forensics, and actinide fundamental science. The evaluations performed by our group are

  6. Recent Science - JCAP

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Recent Science Who We Are JCAP Mission JCAP At A Glance Fact Sheets Organizational Chart Recent Science Technology Transfer Awards & Honors Senior Management Scientific Leadership Researchers Governance & Advisory Boards Operations & Administration Who we are Overview JCAP Mission JCAP At A Glance Fact Sheets Organizational Chart Our Achievements Recent Science Technology Transfer Awards & Honors Our People Senior Management Scientific Leadership Researchers Governance &

  7. Experimental Physical Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ADEPS Experimental Physical Sciences Developing and applying materials science and experimental physics capabilities to programs and problems of national importance. Advancing physics and materials science for problems of national importance Neutrons find "missing" magnetism of plutonium Neutrons find "missing" magnetism of plutonium READ MORE Los Alamos among new DOE projects Create new technology pathways for low-cost fusion energy development READ MORE Combined methods

  8. Fermilab | Science | Historic Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Navbar Toggle About Quick Info Science History Organization Photo and video gallery Diversity Education Safety Sustainability and environment Contact Newsroom Spotlight Press releases Fact sheets and brochures symmetry Interactions.org Photo and video archive Resources for ... Employees Researchers, Postdocs and Graduate Students Job Seekers Neighbors Industry K-12 Students, Teachers and Undergraduates Media Science Particle Physics Neutrinos Fermilab and the LHC Dark matter and dark

  9. ARM - SGP Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science SGP Related Links Virtual Tour Facilities and Instruments Central Facility Boundary Facility Extended Facility Intermediate Facility Radiometric Calibration Facility Geographic Information ES&H Guidance Statement Operations Science Field Campaigns Visiting the Site SGP Fact Sheet Images Information for Guest Scientists Contacts SGP Science Overall Objectives The primary goal of the Southern Great Plains (SGP) site is to produce data adequate to support significant research addressing

  10. ARM - Science Questions

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Questions Related Links CLASIC Home AAF Home ARM Data Discovery Browse Data Post-Campaign CLASIC/CHAPS Special Session at AGU Annual Meeting, December 15-19 CLASIC Workshop, March 26-27 Data Sets Deployment Resources Measurement Platforms PNNL WRF-CuP Forecast Cloud Physics Lidar MODIS Airborne Simulator Data Mesonet Monitoring ARM Data Plots Experiment Planning CLASIC Proposal Abstract Science Questions Science and Implementation Plan (pdf) Measurement Platforms (pdf) CLASIC-Land

  11. ARM - Science Questions

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Questions Related Links ISDAC Home AAF Home AVP Aircraft Instrumentation, October 14-16, 2008 ARM Data Discovery Browse Data Post-Campaign Data Sets Flight Summary Table (PDF, 440K) ISDAC Wiki Mission Summary Journal Deployment Resources NSA Site ARM Data Plots Quick Links Experiment Planning ISDAC Proposal Abstract Full Proposal (pdf, 1,735K) Science Questions Science Overview Document for ISDAC (pdf, 525K) ISDAC Flight Planning Document (PDF, 216K) Collaborations Logistics Measurements

  12. ARM - Science Questions

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Questions Related Links RACORO Home AAF Home ARM Data Discovery Browse Data Post-Campaign Data Sets Data Guide (PDF, 1.4MB) Campaign Journal Flight Details Images ARM flickr site Deployment Operations Measurements Science & Operations Plan (PDF, 640K) SGP Data Plots RACORO wiki Login Required Experiment Planning Steering Committee Science Questions RACORO Proposal Abstract Full Proposal (PDF, 886K) Collaborations Meetings CLOWD Working Group News Discovery Channel Earth Live Blog

  13. Information Sciences and Technology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Information Sciences and Technology Information Sciences and Technology National security depends on science and technology. The United States relies on Los Alamos National Laboratory for the best of both. No place on Earth pursues a broader array of world-class scientific endeavors. Contact thumbnail of Business Development Executive Steve Stringer Business Development Executive Richard P. Feynman Center for Innovation (505) 660-2177 Email Los Alamos leverages advances in theory, algorithms,

  14. Materials Science Applications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Materials Science Applications VASP VASP is a plane wave ab initio code for quantum mechanical molecular dynamics. It is highly scalable and shows very good parallel performance for a variety of chemical and materials science calculations. VASP is available to NERSC users who already have a VASP license. Read More ┬╗ Quantum ESPRESSO/PWscf Quantum Espresso is an integrated suite of computer codes for electronic structure calculations and materials modeling at the nanoscale. It builds on

  15. ARM - NSA Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AlaskaNSA Science NSA Related Links Virtual Tour Facilities and Instruments Barrow Atqasuk Oliktok Point (AMF3) ES&H Guidance Statement Operations Science Field Campaigns Visiting the Site NSA Fact Sheet Images Information for Guest Scientists Contacts NSA Science Scientific objectives for the NSA/AAO site are provided below: Provide the comprehensive data sets necessary to develop and test continually improved algorithms for GCMs to describe radiative transfer and cloud processes at high

  16. ORISE: Science Education Programs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Interested in conducting undergraduate research at Oak Ridge National Laboratory? DOE is currently seeking undergraduate students for paid internships at ORNL for the 2015 spring term of the Science Undergraduate Laboratory Internship Program. The program at ORNL is administered by ORAU, through a contract with DOE to manage ORISE. Oak Ridge Institute for Science Education Science Education Programs The U.S. Department of Energy (DOE) and more than a dozen other federal agencies rely on the Oak

  17. Frontiers in Science Lectures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Frontiers in Science Lectures Frontiers in Science Lectures x Linda Anderman (505) 665-9196 Email The Frontiers in Science lecture series are a public service of the Los Alamos National Laboratory Fellows. Fellows are appointed by the Laboratory Director in recognition of sustained outstanding contributions and exceptional promise for continued professional achievement. All lectures are open to the public and free of charge. LATEST LECTURE Hacking Photosynthesis: Growing Plants to Power Our

  18. Genome Improvement at JGI-HAGSC

    SciTech Connect (OSTI)

    Grimwood, Jane: Schmutz, Jeremy, J.: Myers, Richard, M.

    2012-03-03

    Since the completion of the sequencing of the human genome, the JGI has rapidly expanded its scientific goals in several DOE mission-relevant areas. At the JGI-HAGSC, we have kept pace with this rapid expansion of projects with our focus on assessing, assembling, improving and finishing eukaryotic whole genome shotgun (WGS) projects for which the shotgun sequence is generated at the Production Genomic Facility (JGI-PGF). We follow this by combining the draft WGS with genomic resources generated at JGI-HAGSC or in collaborator laboratories (including BAC end sequences, genetic maps and FLcDNA sequences) to produce an improved draft sequence. For eukaryotic genomes important to the DOE mission, we then add further information from directed experiments to produce reference genomic sequences that are publicly available for any scientific researcher. Also, we have continued our program for producing BAC-based finished sequence, both for adding information to JGI genome projects and for small BAC-based sequencing projects proposed through any of the JGI sequencing programs. We have now built our computational expertise in WGS assembly and analysis and have moved eukaryotic genome assembly from the JGI-PGF to JGI-HAGSC. We have concentrated our assembly development work on large plant genomes and complex fungal and algal genomes.

  19. Science and Suds

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activities and dynamic speakers to engage kids, families and individuals interested in life-long learning in science, technology, engineering, art and math. For the full...

  20. Sandia Science & Technology Park

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratories. More Info Liquid Common SS&TP welcomes Liquid Common Liquid Common is a digital marketing company now located in the Park. More Info Sandia Science & Technology...

  1. National Science Bowl Finals

    ScienceCinema (OSTI)

    None

    2010-09-01

    National Science Bowl finals and awards at the National Building Museum in Washington D.C. Monday 5/3/2010

  2. Science On Tap

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science On Tap Science On Tap WHEN: Apr 16, 2015 5:30 PM - 7:00 PM WHERE: UnQuarked Wine Room 145 Central Park Square, Los Alamos, New Mexico 87544, USA CONTACT: Jessica Privette 505 667-0375 CATEGORY: Bradbury INTERNAL: Calendar Login Science On Tap Presenters Aditya Mohite and Wanyi Nie Event Description Science On Tap happens every third Thursday of the month, featuring a new topic each week. It begins with an informal 15-minute talk and is followed by a lively group discussion. This

  3. Science On Tap

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science On Tap Science On Tap WHEN: Feb 19, 2015 5:30 PM - 7:00 PM WHERE: UnQuarked Wine Room, 145 Central Park Square, Los Alamos, NM 87544 CONTACT: Jessica Privette 505 667-0375 CATEGORY: Bradbury INTERNAL: Calendar Login Science on Tap February Event Description Science On Tap happens every third Thursday of the month. It begins with an informal 15-minute talk followed by a lively group discussion. This week, Harshini Mukundan of Physical Chemistry and Applied Spectroscopy at Los Alamos

  4. Science On Tap

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science On Tap Science On Tap WHEN: Nov 19, 2015 5:30 PM - 7:00 PM WHERE: UnQuarked Wine Room 145 Central Park Square, Los Alamos, NM 87544 USA SPEAKER: Ray Newell, Quantum Encryption CONTACT: Linda Anderman (505) 665-9196 CATEGORY: Bradbury INTERNAL: Calendar Login Science On Tap Event Description Science On Tap happens every third Thursday of the month, featuring a new topic each week. It begins with an informal 15-minute talk and is followed by a lively group discussion. Quantum Cryptography:

  5. Science on Tap

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    January ┬╗ Science on Tap Science on Tap WHEN: Jan 15, 2015 5:30 PM - 7:00 PM WHERE: UnQuarked The Wine Room, 145 Central Park Square, Los Alamos CONTACT: Jessica Privette 505 667-0375 CATEGORY: Bradbury INTERNAL: Calendar Login Science on Tap January Event Description Sara Del Valle of Energy and Infrastructure Analysis (DSA-4) talks about her and her team's research into using Wikipedia to monitor and forecast diseases around the globe. Science on Tap is a project of the Los Alamos Creative

  6. Information Sciences and Technology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    file systems Bioinformatics Infectious disease surveillance Climate change and energy security Smart grids Learn more about our Information Science and Technology capabilities

  7. Basic Energy Sciences Update

    Broader source: Energy.gov (indexed) [DOE]

    Operations Office of Science Vacant Patricia Dehmer (A) Nuclear Physics Tim Hallman Advanced Scientific Computing Research Steve Binkley Nuclear Energy Pete Lyons Fossil Energy...

  8. Science on Tap - Plasmas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science on Tap - Plasmas Science on Tap - Plasmas WHEN: Apr 21, 2016 5:30 PM - 7:00 PM WHERE: UnQuarked Wine Room 145 Central Park Square, Los Alamos, New Mexico 87544 USA CONTACT: Linda Anderman (505) 665-9196 CATEGORY: Bradbury INTERNAL: Calendar Login Science on tap Event Description Science On Tap happens every third Thursday of the month, featuring a new topic each week. It begins with an informal 15-minute talk and is followed by a lively group discussion. Observing the stuff of stars (and

  9. ORISE: Science Education Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ORISE reports track U.S. scientific workforce trends The Oak Ridge Institute for Science and Education (ORISE) has published several reports that analyze labor trends, assess ...

  10. Bradbury Science Museum

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    presentation in yearlong series at Bradbury Science Museum LOS ALAMOS, N.M., Nov. 7, 2013-John C. Hopkins, former associate director for Los Alamos National Laboratory's nuclear...

  11. High School Science Bowl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High School Science Bowl High School Science Bowl WHEN: Feb 07, 2015 8:00 AM - 4:00 PM WHERE: Highland High School 4700 Coal Ave SE, Albuquerque, USA CATEGORY: Community INTERNAL: Calendar Login Event Description The Science Bowl is a Jeopardy-like event for high school and middle school students who have a strong interest in mathematics and science. The competition is in the form of a round robin in the morning and double elimination after lunch. Teams consist of four students and one optional

  12. Science, Technology & Engineering

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    search, Alan Bishop has been selected to be the Laboratory's next Principal Associate Director for - 2 - Science, Technology, and Engineering (PADSTE). Bishop has been acting...

  13. Earth and Environmental Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EES Earth and Environmental Sciences (EES) Sustainable energy, climate impacts, nuclear threat detection, and environmental management are primary focus areas of earth and...

  14. Science Briefs - 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Career Options Maps Mission Science & Engineering Capabilities RELATED NEWS Impact of ... without killing the surrounding healthy tissue.December 20, 2015 Raising the bar on ...

  15. Earth and Environmental Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EES Division Earth and Environmental Sciences We provide solutions to complex problems in climate and environmental change, sustainable energy, and national security. Climate...

  16. Help | ScienceCinema

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FAQ FAQ What is Sciencecinema? ScienceCinema allows users to search for specific words and phrases spoken within video files. Users can then easily access the precise point in the video where the word was spoken. There are two search options within ScienceCinema, the default "Audio Search" and "Fielded Search." What is the content scope of ScienceCinema? Content in ScienceCinema varies topically; however, it is limited to material produced by the DOE National Laboratories,

  17. Science Highlights Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HPC Requirements for Science HPC Workshop Reports NERSC Staff Publications & Presentations Journal Cover Stories Galleries facebook icon Facebook google plus icon Google+ twitter...

  18. Regional Science Bowl 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Doing Business Expand Doing Business Skip navigation links Community & Education Science Bowl 2015 High School Team Photos 2015 Middle School Team Photos Scholarships...

  19. Science, Technology, and Engineering

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    PADSTE Science, Technology, and Engineering Delivering mission success and innovative solutions to national security problems through the agile, rapid application of our...

  20. Science & Technology - 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    technology Science & Technology - 2015 October HAPLS Completes Phase 1 Energy-Ramping Campaign Shaping NIF's Beams for Direct-Drive Experiments September A Pioneering Betatron...

  1. Geospatial Science Steering Committee

    Broader source: Energy.gov [DOE]

    The Geospatial Science Steering Committee (GSSC) functions in an advisory role to the DOE national laboratories, major facilities, and to headquarters and field office elements to actively promote...

  2. CASL - Science Council

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    but may assess due to the importance of multi-physics integration and structural mechanics Physics Integration (PHI) and Advanced Modeling Applications (AMA). The Science...

  3. Ryerson Building Science

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Ryerson Building Science -Zone Residence Project Summary - ZONE is a sustainable approach to infill housing in underutilized urban settings Constrained by buildings to the ...

  4. Science & Technology - 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FAQs Visit Us Science Stockpile Stewardship National Security National Competitiveness Fusion and Ignition Experiments Fast Ignition Energy for the Future How to Make a Star How...

  5. Top Science of 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Improved biofuel methods: greener, cheaper yet powerful science-innovationassets... Improved biofuel methods: may be greener, cheaper, powerful placeholder We've improved ...

  6. Science at NERSC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NERSC HPC Achievement Awards Share Your Research User Submitted Research Citations NERSC Citations Home ┬╗ Science at NERSC Science at NERSC NERSC's core mission is to accelerate the pace of scientific discovery. NERSC and its nearly 6,000 users are are extremely active contributors to all fields of energy-related science in which computation and data analysis play a central role. NERSC is citied in about 1,500 refereed scientific publications per year. A complete list of science articles is at

  7. ARM - Science Questions

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Gerald Mace, Lead Scientist Science Questions Scatter plot of ice crystal number concentration from two different probes used during TWP-ICE. The differences are significant...

  8. ARM Science Plan

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ER-ARM-0402 Atmospheric Radiation Measurement Program Science Plan Current Status and ... Executive Summary The Atmospheric Radiation Measurement (ARM) Program has matured ...

  9. Cassava Genomics: can genomic technology benefit smallholder farmers in Africa? (2014 DOE JGI Genomics of Energy & Environment Meeting)

    SciTech Connect (OSTI)

    Rounsley, Steve

    2014-03-20

    Steve Rounsley of the University of Arizona speaks at the 9th Annual Genomics of Energy & Environment Meeting on March 20, 2014 in Walnut Creek, Calif.

  10. Energy, information science, and systems science

    SciTech Connect (OSTI)

    Wallace, Terry C; Mercer - Smith, Janet A

    2011-02-01

    This presentation will discuss global trends in population, energy consumption, temperature changes, carbon dioxide emissions, and energy security programs at Los Alamos National Laboratory. LANL's capabilities support vital national security missions and plans for the future. LANL science supports the energy security focus areas of impacts of Energy Demand Growth, Sustainable Nuclear Energy, and Concepts and Materials for Clean Energy. The innovation pipeline at LANL spans discovery research through technology maturation and deployment. The Lab's climate science capabilities address major issues. Examples of modeling and simulation for the Coupled Ocean and Sea Ice Model (COSIM) and interactions of turbine wind blades and turbulence will be given.

  11. Genome Engineering with TAL Effector Nucleases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genome Engineering with TAL Effector Nucleases Genome Engineering with TAL Effector Nucleases Print Tuesday, 24 April 2012 09:48 Genome engineering (GE), an emerging discipline in which a DNA sequence is altered at a single position, has a wide variety of potential uses, such as the correction of gene sequences in patients suffering from genetic diseases, the modification or insertion of genes in plants, and the generation of unique cell lines for treatment of diseases such as cancer. GE

  12. Human-mouse comparative genomics: successes and failures to reveal functional regions of the human genome

    SciTech Connect (OSTI)

    Pennacchio, Len A.; Baroukh, Nadine; Rubin, Edward M.

    2003-05-15

    Deciphering the genetic code embedded within the human genome remains a significant challenge despite the human genome consortium's recent success at defining its linear sequence (Lander et al. 2001; Venter et al. 2001). While useful strategies exist to identify a large percentage of protein encoding regions, efforts to accurately define functional sequences in the remaining {approx}97 percent of the genome lag. Our primary interest has been to utilize the evolutionary relationship and the universal nature of genomic sequence information in vertebrates to reveal functional elements in the human genome. This has been achieved through the combined use of vertebrate comparative genomics to pinpoint highly conserved sequences as candidates for biological activity and transgenic mouse studies to address the functionality of defined human DNA fragments. Accordingly, we describe strategies and insights into functional sequences in the human genome through the use of comparative genomics coupled wit h functional studies in the mouse.

  13. Keynote Presentation: Genome Beat (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    ScienceCinema (OSTI)

    Zimmer, Carl [New York Times

    2013-01-22

    Carl Zimmer, a reporter for the New York Times, speaks on "The Genome Beat," the opening keynote presentation at the JGI User 7th Annual Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, Calif

  14. Keynote Presentation: Genome Beat (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    SciTech Connect (OSTI)

    Zimmer, Carl [New York Times] [New York Times

    2012-03-20

    Carl Zimmer, a reporter for the New York Times, speaks on "The Genome Beat," the opening keynote presentation at the JGI User 7th Annual Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, Calif

  15. Science DMZ Implemented at NERSC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NERSC Science Engagement Move your data Programs & Workshops Science Requirements Reviews Case Studies OSCARS Case Studies Science DMZ Case Studies Science DMZ @ UF Science DMZ @ CU Science DMZ @ Penn & VTTI Science DMZ @ NOAA Science DMZ @ NERSC Science DMZ @ ALS Multi-facility Workflow Case Study Contact Us Technical Assistance: 1 800-33-ESnet (Inside US) 1 800-333-7638 (Inside US) 1 510-486-7600 (Globally) 1 510-486-7607 (Globally) Report Network Problems: trouble@es.net Provide Web

  16. Sandia National Labs: Physical, Chemical and Nano Sciences Center...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences Semiconductor & Optical Sciences Energy Sciences Small Science Cluster Business Office News Partnering Research Departments Radiation, Nano Materials, & Interface Sciences...

  17. Diatom Genomics (2009 JGI User Meeting)

    ScienceCinema (OSTI)

    Ambrust, Ginger

    2011-04-25

    Ginger Armbrust from the University of Washington spoke about diatom genomics on March 26, 2009 at the DOE JGI User Meeting

  18. Metagenomics, metatranscriptomics and single cell genomics reveal...

    Office of Scientific and Technical Information (OSTI)

    and single cell genomics reveal functional response of active Oceanospirillales to Gulf oil spill Citation Details In-Document Search Title: Metagenomics, metatranscriptomics and...

  19. History of the DOE Human Genome Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the DOE Human Genome Program The following history is taken from the U.S. Department of Energy 1991-91 Human Genome Program Report (June 1992). This is an archived item. A brief history of the U.S. Department of Energy (DOE) Human Genome Program will be useful in a discussion of the objectives of the DOE program as well as those of the collaborative U.S. Human Genome Project. The Office of Health and Environmental Research (OHER) of DOE and its predecessor agencies--the Atomic Energy

  20. Synthetic Genomics Inc | Open Energy Information

    Open Energy Info (EERE)

    search Name: Synthetic Genomics Inc. Place: La Jolla, California Sector: Hydro, Hydrogen, Renewable Energy Product: California-based company planning to create new types of...

  1. Astronomy Particle Physics Light Sources Genomics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1 - 2 Astronomy Particle Physics Light Sources Genomics Climate * Big Data Software - Broad ecosystem of capabilities and technologies - Research and evaluate - Customize and...

  2. Today, DOE's Joint Genome Institute (a

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in forms of kidney disease, prostate and colorectal cancer, leukemia, hypertension, diabetes, and atherosclerosis. The JGI's DNA Production Genomics Facility is one of the most...

  3. 11th Annual DOE Joint Genome Institute Genomics of Energy & Environment Meeting

    Broader source: Energy.gov [DOE]

    The 11th Annual DOE Joint Genome Institute Genomics of Energy & Environment Meeting will be held March 21ÔÇô25, 2016 in Walnut Creek, California. The meeting will gather together experts and researchers working in energy and environmental genomics and synthetic biology, and it will have a special focus on the work done at the DOE Joint Genome Institute. Bioenergy Technologies Office Technology Manager Daniel Fishman will be in attendance.

  4. SCIENCE ON SATURDAY- "The Large Hadron Collider: big science...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    January 5, 2013, 9:30am Science On Saturday MBG Auditorium SCIENCE ON SATURDAY- "The Large Hadron Collider: big science for big questions" Professor James Olsen Department of ...

  5. Science Highlights | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Science Highlights Fusion Energy Sciences (FES) FES Home About Research Facilities Science Highlights Benefits of FES Funding Opportunities Fusion Energy Sciences Advisory Committee (FESAC) Community Resources Contact Information Fusion Energy Sciences U.S. Department of Energy SC-24/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-4941 F: (301) 903-8584 E: Email Us More Information ┬╗ Science Highlights Print Text Size: A A A Subscribe FeedbackShare Page Filter

  6. Expanding Science and Energy Literacy with America's Science and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Technology Centers | Department of Energy Science and Energy Literacy with America's Science and Technology Centers Expanding Science and Energy Literacy with America's Science and Technology Centers October 20, 2014 - 3:48pm Addthis This new partnership with the Association of Science and Technology Centers aims to increase energy literacy and promote STEM education. | Photo courtesy of the Department of Energy. This new partnership with the Association of Science and Technology Centers

  7. Stewardship Science Academic Programs Annual | National Nuclear...

    National Nuclear Security Administration (NNSA)

    Test, and Evaluation University Partnerships Academic Alliances Stewardship Science Academic Alliances Stewardship Science Academic Programs Annual Stewardship Science...

  8. ESnet's Science DMZ Breaks Down Barriers, Speeds up Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ESnet's Science DMZ Breaks Down Barriers, Speeds up Science News & Publications ESnet News Media & Press Publications and Presentations Galleries ESnet Awards and Honors Contact Us...

  9. Science Highlights | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Leadership Computing Facility (OLCF) Energy Sciences Network (ESnet) BES User ... yellow and red, while negative spins are green and black.) 12.14.15Science Highlight ...

  10. Warp Speed and Lightsabers: Energy Science Fiction vs Energy Science |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Warp Speed and Lightsabers: Energy Science Fiction vs Energy Science Warp Speed and Lightsabers: Energy Science Fiction vs Energy Science March 7, 2014 - 2:20pm Addthis Science fiction has envisioned many ways that mankind might be able to explore distant galaxies, like the spiral galaxy M106 pictured here, but what is science fiction and what could one day be science fact? | Photo Credit: NASA. Science fiction has envisioned many ways that mankind might be able to

  11. Functional Insights from Structural Genomics

    SciTech Connect (OSTI)

    Forouhar,F.; Kuzin, A.; Seetharaman, J.; Lee, I.; Zhou, W.; Abashidze, M.; Chen, Y.; Montelione, G.; Tong, L.; et al

    2007-01-01

    Structural genomics efforts have produced structural information, either directly or by modeling, for thousands of proteins over the past few years. While many of these proteins have known functions, a large percentage of them have not been characterized at the functional level. The structural information has provided valuable functional insights on some of these proteins, through careful structural analyses, serendipity, and structure-guided functional screening. Some of the success stories based on structures solved at the Northeast Structural Genomics Consortium (NESG) are reported here. These include a novel methyl salicylate esterase with important role in plant innate immunity, a novel RNA methyltransferase (H. influenzae yggJ (HI0303)), a novel spermidine/spermine N-acetyltransferase (B. subtilis PaiA), a novel methyltransferase or AdoMet binding protein (A. fulgidus AF{_}0241), an ATP:cob(I)alamin adenosyltransferase (B. subtilis YvqK), a novel carboxysome pore (E. coli EutN), a proline racemase homolog with a disrupted active site (B. melitensis BME11586), an FMN-dependent enzyme (S. pneumoniae SP{_}1951), and a 12-stranded {beta}-barrel with a novel fold (V. parahaemolyticus VPA1032).

  12. Brookhaven Women in Science Lecture

    ScienceCinema (OSTI)

    Johanna Levelt Sengers

    2010-09-01

    Sponsored by Brookhaven Women in Science (BWIS), Johanna Levelt Sengers, Scientist Emeritus at the National Institute of Standards & Technology (NIST), presents a talk titled "The World's Science Academies Address the Under-Representation of Women in Science and Technology."

  13. Open Science Grid at NERSC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Open Science Grid Open Science Grid at NERSC NERSC provides computing to Open Science Grid (OSG) users through a special allocation. OSG Users must submit an OSG new user request...

  14. Neutron and Nuclear Science News

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    News Recent news and events related to neutron and nuclear science at LANSCE. Neutron and Nuclear Science News Links Neutron and Nuclear Science News Media Links Profiles Events at...

  15. Computing and Computational Sciences Directorate - Divisions

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CCSD Divisions Computational Sciences and Engineering Computer Sciences and Mathematics Information Technolgoy Services Joint Institute for Computational Sciences National Center for Computational Sciences

  16. Information Science, Computing, Applied Math

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Capabilities ┬╗ Information Science, Computing, Applied Math /science-innovation/_assets/images/icon-science.jpg Information Science, Computing, Applied Math National security depends on science and technology. The United States relies on Los Alamos National Laboratory for the best of both. No place on Earth pursues a broader array of world-class scientific endeavors. Computer, Computational, and Statistical Sciences (CCS)┬╗ High Performance Computing (HPC)┬╗ Extreme Scale Computing, Co-design┬╗

  17. ARM - ARM Science Team Meetings

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    govScienceARM Science Team Meetings Science Team Meetings 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 ARM Science Team Meetings Poster sessions were key components of the ARM Science Team Meetings through the years. Former ARM Chief Scientist Tom Ackerman (center, dark pants) spent many hours participating in these sessions. Poster sessions were key components of the ARM Science Team Meetings through the years. Former ARM Chief Scientist Tom Ackerman

  18. Science on Tap - Earthquakes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science on Tap - Earthquakes Science on Tap - Earthquakes WHEN: Jan 21, 2016 5:30 PM - Feb 12, 2015 7:00 PM WHERE: UnQuarked Wine Room 145 Central Park Square, Los Alamos, New Mexico 87544 USA SPEAKER: Paul Johnson - Los Alamos National Laboratory CONTACT: Linda Anderman (505) 665-9196 CATEGORY: Bradbury INTERNAL: Calendar Login Event Description Science on Tap happens every third Thursday of the month, featuring a new topic each time. It begins with an informal 15 minute talk and is followed by

  19. Bradbury Science Museum celebrates

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    celebrates its 50th anniversary December 9, 2013 Public reception scheduled Dec. 11 LOS ALAMOS, N.M., Dec. 9, 2013-This year has been one of milestones for Los Alamos National Laboratory, including for its Bradbury Science Museum. To mark the museum's 50th anniversary, the museum will host a reception open to the public from 4 to 6 p.m. Wednesday, Dec. 11. "For 50 years, the Bradbury Science Museum's mission has been to foster enthusiasm and support for science and engineering, and a better

  20. Regional Science Bowl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    January ┬╗ Regional Science Bowl Regional Science Bowl WHEN: Jan 23, 2016 8:00 AM - 5:00 PM WHERE: Highland High School 4700 Coal SE, Albuquerque, NM CONTACT: Janelle Vigil-Maestas (505) 665-4329 CATEGORY: Community INTERNAL: Calendar Login Event Description Five teams from Northern New Mexico area schools are among 16 participating in the middle school Regional Science Bowl competition. Northern area teams participating are from Los Alamos, Espa├▒ola, Cuba and Santa Fe. The winning team at this

  1. COMPUTATIONAL SCIENCE CENTER

    SciTech Connect (OSTI)

    DAVENPORT, J.

    2005-11-01

    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include, for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security. To achieve our goals we have established a close alliance with applied mathematicians and computer scientists at Stony Brook and Columbia Universities.

  2. Genome Structure Gallery from the Mycobacterium Tuberculosis Structual Genomics Consortium

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The TB Structural Genomics Consortium works with the structures of proteins from M. tuberculosis, analyzing these structures in the context of functional information that currently exists and that the Consortium generates. The database of linked structural and functional information constructed from this project will form a lasting basis for understanding M. tuberculosis pathogenesis and for structure-based drug design. The Consortium's structural and functional information is publicly available. The Structures Gallery makes more than 650 total structures available by PDB identifier. Some of these are not consortium targets, but all are viewable in 3D color and can be manipulated in various ways by Jmol, an open-source Java viewer for chemical structures in 3D from http://www.jmol.org/

  3. Quality Scores for 32,000 Genomes

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Land, Miriam L; Hyatt, Philip Douglas; Jun, Se Ran; Kora, Guruprasad H; Hauser, Loren John; Ussery, David W

    2014-01-01

    More than 80% of the microbial genomes in GenBank are of draft quality (12,553 draft vs. 2,679 finished, as of October, 2013). We examined the microbial DNA sequences available for complete, draft, and Sequence Read Archive genomes in GenBank as well as three other major public databases and assigned quality scores for more than 30,000 prokaryotic genome sequences. Scores were assigned using four categories: the completeness of the assembly, the presence of full-length rRNA genes, tRNA composition and the presence of a set of 120 conserved genes in prokaryotes. Most (~87.6%) of the genomes had quality scores of 0.8 ormore┬á┬╗ better and can be safely used for standard comparative genomics analysis, although only 6.1% of the genomes had a perfect quality score. We find that about 2.9% of the genomes had a score below 0.6 and probably have too low a quality to yield reliable analysis. This score corresponds to more than 1000 contigs. Comparison of the codon usage across 15,000 quality genomes found that anti-codons beginning with an A (codons ending with a U ) are almost non-existent, with the exception of one arginine codon (CGU).┬ź┬áless

  4. Fungal biology: compiling genomes and exploiting them

    SciTech Connect (OSTI)

    Labbe, Jessy L; Uehling, Jessie K; Payen, Thibaut; Plett, Jonathan

    2014-01-01

    The last 10 years have seen the cost of sequencing complete genomes decrease at an incredible speed. This has led to an increase in the number of genomes sequenced in all the fungal tree of life as well as a wide variety of plant genomes. The increase in sequencing has permitted us to study the evolution of organisms on a genomic scale. A number of talks during the conference discussed the importance of transposable elements (TEs) that are present in almost all species of fungi. These TEs represent an especially large percentage of genomic space in fungi that interact with plants. Thierry Rouxel (INRA, Nancy, France) showed the link between speciation in the Leptosphaeria complex and the expansion of TE families. For example in the Leptosphaeria complex, one species associated with oilseed rape has experienced a recent and massive burst of movement by a few TE families. The alterations caused by these TEs took place in discrete regions of the genome leading to shuffling of the genomic landscape and the appearance of genes specific to the species, such as effectors useful for the interactions with a particular plant (Rouxel et al., 2011). Other presentations showed the importance of TEs in affecting genome organization. For example, in Amanita different species appear to have been invaded by different TE families (Veneault-Fourrey & Martin, 2011).

  5. Uses of antimicrobial genes from microbial genome

    DOE Patents [OSTI]

    Sorek, Rotem; Rubin, Edward M.

    2013-08-20

    We describe a method for mining microbial genomes to discover antimicrobial genes and proteins having broad spectrum of activity. Also described are antimicrobial genes and their expression products from various microbial genomes that were found using this method. The products of such genes can be used as antimicrobial agents or as tools for molecular biology.

  6. Science Undergraduate Laboratory Internships (SULI)

    Broader source: Energy.gov [DOE]

    The Science Undergraduate Laboratory Internship (SULI) program encourages undergraduate students to pursue science, technology, engineering, and mathematics (STEM) careers by providing research...

  7. ORISE Science Education Programs: Capabilities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Capabilities Science Education Programs Capabilities The Oak Ridge Institute for Science and Education (ORISE) connects the best and most diverse students and faculty members to...

  8. Science Highlights | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    News Press Releases Features Science Highlights In the News Photos Videos Science Highlights Topic - Any - General Argonne Information -Awards -Honors Energy -Energy efficiency...

  9. APS Science | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science APS Science features articles on Advanced Photon Source research and engineering highlights that are written for the interested public as well as the synchrotron x-ray,...

  10. Neutron and Nuclear Science Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publications Recent publications related to neutron and nuclear science at LANSCE. Neutron and Nuclear Science Publications Chi-Nu Publications DANCE Publications GEANIE...

  11. 2014 Science of Signatures Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Email 2014 Science of Signatures Program Agenda 2014 Projects and Teams 2014 Science of Signatures Speakers and Presentations LDRD Penta Chart Template ER Proposal Template...

  12. 2015 Science of Signatures Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science of Signatures Program Agenda (PDF) 2015 Projects and Teams 2015 Science of Signatures Speakers and Presentations LDRD Penta Chart Template (PDF) ER Proposal Template (PDF)...

  13. Microbial ecology and genomics: A crossroads of opportunity

    SciTech Connect (OSTI)

    Stahl, David A.; Tiedje, James M.

    2002-08-30

    Microbes have dominated life on Earth for most of its 4.5 billionyear history. They are the foundation of the biosphere, controlling the biogeochemical cycles and affecting geology, hydrology, and local and global climates. All life is completely dependent upon them. Humans cannot survive without the rich diversity of microbes, but most microbial species can survive without humans. Extraordinary advances in molecular technology have fostered an explosion of information in microbial biology. It is now known that microbial species in culture poorly represent their natural diversityÔÇöwhich dwarfs conventions established for the visible world. This was revealed over the last decade using newer molecular tools to explore environmental diversity and has sparked an explosive growth in microbial ecology and technologies that may profit from the bounty of natural biochemical diversity. Several colloquia and meetings have helped formulate policy recommendations to enable sustained research programs in these areas. One such colloquium organized by the American Academy of Microbiology (ÔÇťThe Microbial World: Foundation of the Biosphere,ÔÇŁ 1997) made two key recommendations: (1) develop a more complete inventory of living organisms and the interagency cooperation needed to accomplish this goal, and (2) develop strategies to harvest this remarkable biological diversity for the benefit of science, technology, and society. Complete genome sequence information was identified as an essential part of strategy development, and the recommendation was made to sequence the genome of at least one species of each of the major divisions of microbial life.

  14. Implications of structural genomics target selection strategies: Pfam5000,

    Office of Scientific and Technical Information (OSTI)

    whole genome, and random approaches (Journal Article) | SciTech Connect Implications of structural genomics target selection strategies: Pfam5000, whole genome, and random approaches Citation Details In-Document Search Title: Implications of structural genomics target selection strategies: Pfam5000, whole genome, and random approaches The structural genomics project is an international effort to determine the three-dimensional shapes of all important biological macromolecules, with a primary

  15. The Arabidopsis lyrata genome sequence and the basis of rapid genome size change

    SciTech Connect (OSTI)

    Hu, Tina T.; Pattyn, Pedro; Bakker, Erica G.; Cao, Jun; Cheng, Jan-Fang; Clark, Richard M.; Fahlgren, Noah; Fawcett, Jeffrey A.; Grimwood, Jane; Gundlach, Heidrun; Haberer, Georg; Hollister, Jesse D.; Ossowski, Stephan; Ottilar, Robert P.; Salamov, Asaf A.; Schneeberger, Korbinian; Spannagl, Manuel; Wang, Xi; Yang, Liang; Nasrallah, Mikhail E.; Bergelson, Joy; Carrington, James C.; Gaut, Brandon S.; Schmutz, Jeremy; Mayer, Klaus F. X.; Van de Peer, Yves; Grigoriev, Igor V.; Nordborg, Magnus; Weigel, Detlef; Guo, Ya-Long

    2011-04-29

    In our manuscript, we present a high-quality genome sequence of the Arabidopsis thaliana relative, Arabidopsis lyrata, produced by dideoxy sequencing. We have performed the usual types of genome analysis (gene annotation, dN/dS studies etc. etc.), but this is relegated to the Supporting Information. Instead, we focus on what was a major motivation for sequencing this genome, namely to understand how A. thaliana lost half its genome in a few million years and lived to tell the tale. The rather surprising conclusion is that there is not a single genomic feature that accounts for the reduced genome, but that every aspect centromeres, intergenic regions, transposable elements, gene family number is affected through hundreds of thousands of cuts. This strongly suggests that overall genome size in itself is what has been under selection, a suggestion that is strongly supported by our demonstration (using population genetics data from A. thaliana) that new deletions seem to be driven to fixation.

  16. Genomic definition of species. Revision 2

    SciTech Connect (OSTI)

    Crkvenjakov, R.; Drmanac, R.

    1993-03-01

    A genome is the sum total of the DNA sequences in the cells of an individual organism. The common usage that species possess genomes comes naturally to biochemists, who have shown that all protein and nucleic acid molecules are at the same time species- and individual-specific, with minor individual variations being superimposed on a consensus sequence that is constant for a species. By extension, this property is attributed to the common features of DNA in the chromosomes of members of a given species and is called species genome. Our proposal for the definition of a biological species is as follows: A species comprises a group of actual and potential biological organisms built according to a unique genome program that is recorded, and at least in part expressed, in the structures of their genomic nucleic acid molecule(s), having intragroup sequence differences which can be fully interconverted in the process of organismal reproduction.

  17. Help | ScienceCinema

    Office of Scientific and Technical Information (OSTI)

    video files. Users can then easily access the precise point in the video where the word was spoken. There are two search options within ScienceCinema, the default "Audio...

  18. Bradbury Science Museum

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    celebrates NanoDays 2013. NanoDays is a national campaign, engaging people of all ages in learning about the emerging field of nanoscale science and engineering. The Bradbury...

  19. Fermilab Science Education Office

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Off or Not Supported in Your Browser. You can still access all of the content on the Education Server about Science Education, but turn on JavaScript to enable all this site's...

  20. Bradbury Science Museum

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Astronomy days lectures begin July 8 at Bradbury Science Museum July 2, 2008 LOS ALAMOS, New Mexico, July 2, 2008-A series of six evening lectures that focus on astronomy and the...

  1. PHYSICAL SCIENCES, Physics Phase

    Office of Scientific and Technical Information (OSTI)

    SCIENCES, Physics Phase competition in trisected superconducting dome I. M. Vishik, 1, 2 M Hashimoto, 3 R.-H. He, 4 W. S. Lee, 1, 2 F. Schmitt, 1, 2 D. H. Lu, 3 R. G. Moore, 1...

  2. It Starts with Science...

    ScienceCinema (OSTI)

    Chu, Steven

    2013-05-29

    Secretary Chu sits down with a journalism student at Carnegie Mellon's Education City campus in Qatar to discuss the value of science in education and what attracted him to the study of Physics.

  3. NP Science Network Requirements

    SciTech Connect (OSTI)

    Dart, Eli; Rotman, Lauren; Tierney, Brian

    2011-08-26

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the U.S. Department of Energy (DOE) Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. To support SC programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In August 2011, ESnet and the Office of Nuclear Physics (NP), of the DOE SC, organized a workshop to characterize the networking requirements of the programs funded by NP. The requirements identified at the workshop are summarized in the Findings section, and are described in more detail in the body of the report.

  4. Science Briefs - 2011

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4% DOE Office of Science 3% Energy and other programs 11% Work for Others Demographics (LANS and students only) 34% of employees live in Los Alamos, the remainder commute...

  5. It Starts with Science...

    Broader source: Energy.gov [DOE]

    Secretary Chu sits down with a journalism student at Carnegie Mellon's Education City campus in Qatar to discuss the value of science in education and what attracted him to the study of Physics.

  6. ARM - AMF Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2009-2010 Shouxian, China, 2008 Black Forest, Germany, 2007 Niamey, Niger, 2006 Point Reyes, California, 2005 AMF Science Locale: Anywhere in the World The purpose of an ARM...

  7. About Science Bowl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Volunteers - Sign Up About Science Bowl Curriculum and Activities How to Build a Motor The Great Marble Drop How to Build a Turbine How to Build a Tower Classroom...

  8. ScienceFest

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Show your passion for innovation with a creative talk July 22, 2014 Presentations sought for TechRev Day at Los Alamos ScienceFest LOS ALAMOS, N.M., July 22, 2014-Organizers of Los...

  9. Science & Technology - 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    example is the use of betatron x-ray radiation for research in the growing field of high energy density (HED) science on extremely short time and length scales (energy density is...

  10. DOE JGI Whole Genome Shotgun Sequencing, part 2

    ScienceCinema (OSTI)

    Miranda Harmon-Smith

    2010-09-01

    A Howard Hughes Medical Institute (HHMI) video production describing the Whole Genome Shotgun Sequencing process at the US Department of Energy's Joint Genome Institute (JGI).

  11. DOE JGI Whole Genome Shotgun Sequencing, part 3

    ScienceCinema (OSTI)

    Miranda Harmon-Smith

    2010-09-01

    A Howard Hughes Medical Institute (HHMI) video production describing the Whole Genome Shotgun Sequencing process at the US Department of Energy's Joint Genome Institute (JGI).

  12. Electrolyte Genome Could Be Battery Game-Changer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Electrolyte Genome Could Be Battery Game-Changer Electrolyte Genome Could Be Battery Game-Changer The Materials Project screens molecules to accelerate electrolyte discovery April...

  13. 2013 Progress Report -- DOE Joint Genome Institute (Program Document...

    Office of Scientific and Technical Information (OSTI)

    Program Document: 2013 Progress Report -- DOE Joint Genome Institute Citation Details In-Document Search Title: 2013 Progress Report -- DOE Joint Genome Institute In October 2012, ...

  14. Using Genomics to Dissect Seed Development (JGI Seventh Annual...

    Office of Scientific and Technical Information (OSTI)

    Using Genomics to Dissect Seed Development (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment Meeting) Citation Details In-Document Search Title: Using...

  15. Next Generation Sequencing at the University of Chicago Genomics...

    Office of Scientific and Technical Information (OSTI)

    The University of Chicago Genomics Core provides University of Chicago investigators (and external clients) access to State-of-the-Art genomics capabilities: next generation ...

  16. DOE JGI Whole Genome Shotgun Sequencing, part 1

    ScienceCinema (OSTI)

    Miranda Harmon-Smith

    2010-09-01

    A Howard Hughes Medical Institute (HHMI) video production describing the Whole Genome Shotgun Sequencing process at the US Department of Energy's Joint Genome Institute (JGI).

  17. Achievements of structural genomics (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Conference: Achievements of structural genomics Citation Details In-Document Search Title: Achievements of structural genomics You are accessing a document from the Department...

  18. Achievements of structural genomics (Journal Article) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Journal Article: Achievements of structural genomics Citation Details In-Document Search Title: Achievements of structural genomics You are accessing a document from the...

  19. Structural Genomics of Minimal Organisms: Pipeline and Results...

    Office of Scientific and Technical Information (OSTI)

    Book: Structural Genomics of Minimal Organisms: Pipeline and Results Citation Details In-Document Search Title: Structural Genomics of Minimal Organisms: Pipeline and Results The ...

  20. Fueling Future with Algal Genomics (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    carbon cycle, and are prominent candidates for biofuel production. The US Department of Energy Joint Genome Institute (JGI) is leading the world in algal genome sequencing...

  1. Using Genomics to Dissect Seed Development (JGI Seventh Annual...

    Office of Scientific and Technical Information (OSTI)

    Seed Development (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment Meeting) Citation Details In-Document Search Title: Using Genomics to Dissect Seed...

  2. Science & Technology - 2014

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 Science & Technology - 2014 July International Team Conducts First Collisionless Shock Experiment on NIF The first NIF Discovery Science experiment designed to create and study fully formed collisionless shocks, such as those responsible for the properties of many astrophysical phenomena including supernova remnants, gamma-ray bursts, jets from active galactic nuclei, and cosmic ray acceleration, was performed on July 29. Tycho Supernova Chandra X-ray Observatory photo of the Tycho

  3. Alliance for Science

    Broader source: Energy.gov [DOE]

    EMÔÇÖs Jud Lilly explains the nuclear fuel cycle to a group of students participating in the recent Sixth Annual Science Alliance at the Portsmouth Gaseous Diffusion Plant site in southern Ohio. A record 1,255 high school juniors attended and participated in interactive demonstrations designed to match their interests with potential careers related to science, technology, engineering and math. Students also learned about post-secondary educational requirements for those careers and regional universities that offer the necessary curricula.

  4. Science Gateways : Demos

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Demos Science Gateways : Demos Most science gateway services require authentication to access compute and data resources. If you're not a NERSC user this will limit the scope of the examples below. If you are a NERSC user please login with your NERSC username and password to enable the examples below. demo set 1 Last edited: 2016-02-01 08:06:05

  5. Chemical Sciences Project Description

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Modeling & Simulation Data Analysis and Modeling & Simulation for the Chemical Sciences Project Description Almos every scientific activity at Los Alamos involves data analysis and modeling. From a chemical sciences point of view, such work transforms "raw" data into a form that provides useful information that is predictive, confirmatory, or exploratory. The key to understanding the world around us is the ability to put the chemical data we collect into a meaningful context

  6. Frontiers in Science Lectures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lectures focus on saving energy through superconductivity June 12, 2009 LOS ALAMOS, New Mexico, June 12, 2009-Los Alamos National Laboratory scientist Dean Peterson discusses the science of high-temperature superconductivity in a series of Frontiers in Science lectures starting June 16 at the Duane W. Smith Auditorium at Los Alamos High School. In the talk, titled "Lost In Transmission: Saving Energy With Superconductivity," Peterson, of the Laboratory's Superconductivity Technology

  7. ARM - Science Project Ideas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TeachersScience Project Ideas Outreach Home Room News Publications Traditional Knowledge Kiosks Barrow, Alaska Tropical Western Pacific Site Tours Contacts Students Study Hall About ARM Global Warming FAQ Just for Fun Meet our Friends Cool Sites Teachers Teachers' Toolbox Lesson Plans Science Project Ideas Do changes in air pressure affect the weather? What is the relationship between air pressure and temperature? Monitor the weather forecast data from the web to find the answer. How does the

  8. About | ScienceCinema

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    About About ScienceCinema ScienceCinema uses innovative, state-of-the-art audio indexing and speech recognition technology from Microsoft Research to allow users to quickly find video files produced by the DOE National Laboratories, other DOE research facilities, and the European Organization for Nuclear Research (CERN). Users can search for specific words and phrases, and precise snippets of the video where the search term was spoken will appear along with a timeline. Users can then select a

  9. Computational Earth Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6 Computational Earth Science We develop and apply a range of high-performance computational methods and software tools to Earth science projects in support of environmental health, cleaner energy, and national security. Contact Us Group Leader Carl Gable Deputy Group Leader Gilles Bussod Email Profile pages header Search our Profile pages Hari Viswanathan inspects a microfluidic cell used to study the extraction of hydrocarbon fuels from a complex fracture network. EES-16's Subsurface Flow

  10. Brookhaven Science Associates, LLC

    Office of Environmental Management (EM)

    23, 2015 Dr. Doon L. Gibbs Laboratory Director Brookhaven Science Associates, LLC Brookhaven National Laboratory 40 Brookhaven Avenue Upton, New York 11973-5000 WCO-2015-02 Dear Dr. Gibbs: The Office of Enterprise Assessments' Office of Enforcement completed its investigation into the facts and circumstances associated with the meteorological tower electrical shock event that occurred at the Brookhaven National Laboratory on November 12, 2014. Brookhaven Science Associates, LLC (BSA) documented

  11. ARM - Other Science Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SitesOther Science Resources Outreach Home Room News Publications Traditional Knowledge Kiosks Barrow, Alaska Tropical Western Pacific Site Tours Contacts Students Study Hall About ARM Global Warming FAQ Just for Fun Meet our Friends Cool Sites Teachers Teachers' Toolbox Lesson Plans Other Science Resources AIMS Education Foundation This website offers tools, activities, and information "designed by teachers for teachers." AIMS activities and curricula are extensively field tested and

  12. Home | ScienceCinema

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ScienceCinema Database Searchable Videos Showcasing DOE Research Search DOE ScienceCinema for Multimedia Find + Fielded Search Audio Search ├Ś Fielded Search Title: Description/Abstract: Bibliographic Data: Author/Speaker: Name Name ORCID Media Type: All Audio Video Subject: Identifier Numbers: Media Source: All DOE CERN Research Org.: Sponsoring Org.: Publication Date: Publication Date Until to System Entry Date: Publication Date Until to Sort: Relevance Publication Date (Newest to Oldest)

  13. LASSO* - Science Requirements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    LASSO* - Science Requirements *LES ARM Symbiotic Simulation and Observation (LASSO) workflow Andy Vogelmann 1 , William I Gustafson Jr 2 Zhijin Li 3,4 , Xiaoping Cheng 3 , Satoshi Endo 1 , Tami Toto 1 , and Heng Xiao 2 1 Brookhaven National Laboratory 2 Pacific Northwest National Laboratory 3 University of California Los Angeles 4 NASA Jet Propulsion Laboratory And TONS of people from the rest of ARM! LASSO Webpage: http://www.arm.gov/science/themes/lasso LASSO e-mail list sign up:

  14. Lab grants Decision Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    grants Decision Sciences Corporation exclusive commercial license for muon tomography October 7, 2008 LOS ALAMOS, New Mexico, October 7, 2008-Los Alamos National Laboratory has granted Decision Sciences Corporation (DSC) an exclusive worldwide license to commercialize muon tomography, a LANL-developed technology. Muon tomography uses naturally occurring cosmic-ray muons, a type of subatomic particle, to detect and identify concealed nuclear threat materials based on their atomic number and

  15. Science Highlights Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Highlights Presentations Science Highlights Presentations NERSC collects highlights of recent scientific work carried out by its users. If you are a user and have work that you would like us to highlight please send e-mail to consult@nersc.gov. In the list below, names of researchers who did the work appear in brackets. December 2015 Presentation [PDF] Creating Nanoscale Ferroelectricity from a Nonferroelectric Film [X. Wu, Temple University, Science, 349, 6254, 1314-1317, Sep. 2015] [BES]

  16. Science | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Argonne Research Library supports the scientific and technical research of the employees of Argonne National Laboratory. While the library is not open to the public, we do make our catalog available for searching. Women in Science and Technology (WIST) aims to promote the success of women in scientific and technical positions at Argonne. Science The best and brightest minds come to Argonne to make scientific discoveries and technological innovations that improve the quality of life

  17. MISSOURI UNIVERSITY OF SCIENCE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY (MS&T) RPSEA SUBCONTRACT# 11123-14 DR. BAOJUN BAI PRINCIPAL INVESTIGATOR STUDY AND PILOT TEST OF PREFORMED PARTICLE GEL CONFORMANCE CONTROL COMBINED WITH SURFACTANT TREATMENT Final Report Covering the period from November 2012 to August 2015 Prime Contractor's Technical Point of Contact: Baojun Bai Phone: 573-341-4016; Email: baib@mst.edu Missouri University of Science and Technology August 2015 Study and Pilot Test of Preformed Particle Gel

  18. Accelerator Science | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Thomas Jefferson Site Office Staff Cryomodules, sections of Jefferson Lab's accelerator, are designed, assembled, tested and maintained in the Test Lab building. A D D I T I O N A L L I N K S: SRF Institute CASA Operations Injector Group CEBAF About Accelerators top-right bottom-left-corner bottom-right-corner Accelerator Science Jefferson Lab is recognized as a world leader in accelerator science. This expertise comes from the planning, building, maintaining and operating of the

  19. The Crucibles Science Club Wins Colorado Science Bowl - News Releases |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NREL The Crucibles Science Club Wins Colorado Science Bowl Team Heads to Washington D.C. to Challenge Students from Across the USA for National Title January 31, 2009 Photo of the winning team at the Colorado Science Bowl. The Crucibles Science Club (team one) was the winner of this year's Colorado Science Bowl and heads to Washington D.C. in April to compete for the national title. Students from The Crucibles Science Club in Denver won the Colorado High School Science Bowl today. In the

  20. Catalysis Science | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Catalysis Science Chemical Sciences, Geosciences, & Biosciences (CSGB) Division CSGB Home About Research Areas Energy Frontier Research Centers (EFRCs) DOE Energy Innovation Hubs Reports and Activities Science Highlights Principal Investigators' Meetings BES Home Research Areas Catalysis Science Print Text Size: A A A FeedbackShare Page Notice: NOVEMBER 16, 2015 is the Catalysis Science target date for submission of proposals to be considered for funding within fiscal year 2016. Proposals

  1. Science Bowl | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Bowl Iowa Regional High School Science Bowl January 23, 2016 About Coach Information Volunteers Schedule 2016 Participating teams 2016 Results Iowa Regional Middle School Science Bowl Registration is Closed (event is full) February 20, 2016 About Coach Information Volunteers Schedule 2016 Participating Teams 2016 Results 2013 National Science Bowl video (YouTube) Contact Sponsors Image

  2. Genome Sequence of the Palaeopolyploid soybean

    SciTech Connect (OSTI)

    Schmutz, Jeremy; Cannon, Steven B.; Schlueter, Jessica; Ma, Jianxin; Mitros, Therese; Nelson, William; Hyten, David L.; Song, Qijian; Thelen, Jay J.; Cheng, Jianlin; Xu, Dong; Hellsten, Uffe; May, Gregory D.; Yu, Yeisoo; Sakura, Tetsuya; Umezawa, Taishi; Bhattacharyya, Madan K.; Sandhu, Devinder; Valliyodan, Babu; Lindquist, Erika; Peto, Myron; Grant, David; Shu, Shengqiang; Goodstein, David; Barry, Kerrie; Futrell-Griggs, Montona; Abernathy, Brian; Du, Jianchang; Tian, Zhixi; Zhu, Liucun; Gill, Navdeep; Joshi, Trupti; Libault, Marc; Sethuraman, Anand; Zhang, Xue-Cheng; Shinozaki, Kazuo; Nguyen, Henry T.; Wing, Rod A.; Cregan, Perry; Specht, James; Grimwood, Jane; Rokhsar, Dan; Stacey, Gary; Shoemaker, Randy C.; Jackson, Scott A.

    2009-08-03

    Soybean (Glycine max) is one of the most important crop plants for seed protein and oil content, and for its capacity to fix atmospheric nitrogen through symbioses with soil-borne microorganisms. We sequenced the 1.1-gigabase genome by a whole-genome shotgun approach and integrated it with physical and high-density genetic maps to create a chromosome-scale draft sequence assembly. We predict 46,430 protein-coding genes, 70percent more than Arabidopsis and similar to the poplar genome which, like soybean, is an ancient polyploid (palaeopolyploid). About 78percent of the predicted genes occur in chromosome ends, which comprise less than one-half of the genome but account for nearly all of the genetic recombination. Genome duplications occurred at approximately 59 and 13 million years ago, resulting in a highly duplicated genome with nearly 75percent of the genes present in multiple copies. The two duplication events were followed by gene diversification and loss, and numerous chromosome rearrangements. An accurate soybean genome sequence will facilitate the identification of the genetic basis of many soybean traits, and accelerate the creation of improved soybean varieties.

  3. Genome Sequence Databases (Overview): Sequencing and Assembly

    SciTech Connect (OSTI)

    Lapidus, Alla L.

    2009-01-01

    From the date its role in heredity was discovered, DNA has been generating interest among scientists from different fields of knowledge: physicists have studied the three dimensional structure of the DNA molecule, biologists tried to decode the secrets of life hidden within these long molecules, and technologists invent and improve methods of DNA analysis. The analysis of the nucleotide sequence of DNA occupies a special place among the methods developed. Thanks to the variety of sequencing technologies available, the process of decoding the sequence of genomic DNA (or whole genome sequencing) has become robust and inexpensive. Meanwhile the assembly of whole genome sequences remains a challenging task. In addition to the need to assemble millions of DNA fragments of different length (from 35 bp (Solexa) to 800 bp (Sanger)), great interest in analysis of microbial communities (metagenomes) of different complexities raises new problems and pushes some new requirements for sequence assembly tools to the forefront. The genome assembly process can be divided into two steps: draft assembly and assembly improvement (finishing). Despite the fact that automatically performed assembly (or draft assembly) is capable of covering up to 98% of the genome, in most cases, it still contains incorrectly assembled reads. The error rate of the consensus sequence produced at this stage is about 1/2000 bp. A finished genome represents the genome assembly of much higher accuracy (with no gaps or incorrectly assembled areas) and quality ({approx}1 error/10,000 bp), validated through a number of computer and laboratory experiments.

  4. Extreme Science (LBNL Science at the Theater)

    SciTech Connect (OSTI)

    Ajo-Franklin, Caroline; Klein, Spencer; Minor, Andrew; Torok, Tamas

    2012-02-27

    On Feb. 27, 2012 at the Berkeley Repertory Theatre, four Berkeley Lab scientists presented talks related to extreme science - and what it means to you. Topics include: Neutrino hunting in Antarctica. Learn why Spencer Klein goes to the ends of the Earth to search for these ghostly particles. From Chernobyl to Central Asia, Tamas Torok travels the globe to study microbial diversity in extreme environments. Andrew Minor uses the world's most advanced electron microscopes to explore materials at ultrahigh stresses and in harsh environments. And microbes that talk to computers? Caroline Ajo-Franklin is pioneering cellular-electrical connections that could help transform sunlight into fuel.

  5. Annotation of the Clostridium Acetobutylicum Genome

    SciTech Connect (OSTI)

    Daly, M. J.

    2004-06-09

    The genome sequence of the solvent producing bacterium Clostridium acetobutylicum ATCC824, has been determined by the shotgun approach. The genome consists of a 3.94 Mb chromosome and a 192 kb megaplasmid that contains the majority of genes responsible for solvent production. Comparison of C. acetobutylicum to Bacillus subtilis reveals significant local conservation of gene order, which has not been seen in comparisons of other genomes with similar, or, in some cases, closer, phylogenetic proximity. This conservation allows the prediction of many previously undetected operons in both bacteria.

  6. National Science Bowl 2013 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Science Bowl 2013 National Science Bowl 2013 Addthis National Science Bowl 2013 1 of 16 National Science Bowl 2013 The 2013 National Science Bowl started off at the 4H Center,...

  7. COMPUTATIONAL SCIENCE CENTER

    SciTech Connect (OSTI)

    DAVENPORT, J.

    2006-11-01

    Computational Science is an integral component of Brookhaven's multi science mission, and is a reflection of the increased role of computation across all of science. Brookhaven currently has major efforts in data storage and analysis for the Relativistic Heavy Ion Collider (RHIC) and the ATLAS detector at CERN, and in quantum chromodynamics. The Laboratory is host for the QCDOC machines (quantum chromodynamics on a chip), 10 teraflop/s computers which boast 12,288 processors each. There are two here, one for the Riken/BNL Research Center and the other supported by DOE for the US Lattice Gauge Community and other scientific users. A 100 teraflop/s supercomputer will be installed at Brookhaven in the coming year, managed jointly by Brookhaven and Stony Brook, and funded by a grant from New York State. This machine will be used for computational science across Brookhaven's entire research program, and also by researchers at Stony Brook and across New York State. With Stony Brook, Brookhaven has formed the New York Center for Computational Science (NYCCS) as a focal point for interdisciplinary computational science, which is closely linked to Brookhaven's Computational Science Center (CSC). The CSC has established a strong program in computational science, with an emphasis on nanoscale electronic structure and molecular dynamics, accelerator design, computational fluid dynamics, medical imaging, parallel computing and numerical algorithms. We have been an active participant in DOES SciDAC program (Scientific Discovery through Advanced Computing). We are also planning a major expansion in computational biology in keeping with Laboratory initiatives. Additional laboratory initiatives with a dependence on a high level of computation include the development of hydrodynamics models for the interpretation of RHIC data, computational models for the atmospheric transport of aerosols, and models for combustion and for energy utilization. The CSC was formed to bring together researchers in these areas and to provide a focal point for the development of computational expertise at the Laboratory. These efforts will connect to and support the Department of Energy's long range plans to provide Leadership class computing to researchers throughout the Nation. Recruitment for six new positions at Stony Brook to strengthen its computational science programs is underway. We expect some of these to be held jointly with BNL.

  8. Research Staff | Materials Science | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Staff Research staff members in NREL's Materials Science Center are aligned within four groups: Materials Physics, Analytical Microscopy and Imaging Science, Interfacial and Surface Science, and Thin-Film Materials Science and Processing. For lead researcher contacts, see our research areas. For our business contact, see Work with Us. Photo of Nancy Haegel Nancy Haegel Center Director, Materials Science Center Email | 303-384-6548 Materials Physics Photo of Angelo Mascarenhas Angelo

  9. The Methanosarcina barkeri genome: comparative analysis withMethanosarcina

    Office of Scientific and Technical Information (OSTI)

    acetivorans and Methanosarcina mazei reveals extensiverearrangement within methanosarcinal genomes (Journal Article) | SciTech Connect Journal Article: The Methanosarcina barkeri genome: comparative analysis withMethanosarcina acetivorans and Methanosarcina mazei reveals extensiverearrangement within methanosarcinal genomes Citation Details In-Document Search Title: The Methanosarcina barkeri genome: comparative analysis withMethanosarcina acetivorans and Methanosarcina mazei reveals

  10. What Makes Science, Science? Research, Shared Effort ... & A New Office of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Science Website | Department of Energy Makes Science, Science? Research, Shared Effort ... & A New Office of Science Website What Makes Science, Science? Research, Shared Effort ... & A New Office of Science Website March 28, 2011 - 12:10pm Addthis Charles Rousseaux Charles Rousseaux Senior Communications Specialist (detailee) What makes science, science? To find out, click into the new Office of Science (SC) website. You'll see what science is about on the new Office of Science

  11. Water, law, science

    SciTech Connect (OSTI)

    Narasimhan, T.N.

    2007-10-17

    In a world with water resources severely impacted bytechnology, science must actively contribute to water law. To this end,this paper is an earth scientist s attempt to comprehend essentialelements of water law, and to examine their connections to science.Science and law share a common logical framework of starting with apriori prescribed tenets, and drawing consistent inferences. In science,observationally established physical laws constitute the tenets, while inlaw, they stem from social values. The foundations of modern water law inEurope and the New World were formulated nearly two thousand years ago byRoman jurists who were inspired by Greek philosophy of reason.Recognizing that vital natural elements such as water, air, and the seawere governed by immutable natural laws, they reasoned that theseelements belonged to all humans, and therefore cannot be owned as privateproperty. Legally, such public property was to be governed by jusgentium, the law of all people or the law of all nations. In contrast,jus civile or civil law governed private property. Remarkably, jusgentium continues to be relevant in our contemporary society in whichscience plays a pivotal role in exploiting vital resources common to all.This paper examines the historical roots of modern water law, followstheir evolution through the centuries, and examines how the spirit ofscience inherent in jus gentium is profoundly influencing evolving waterand environmental laws in Europe, the United States and elsewhere. In atechnological world, scientific knowledge has to lie at the core of waterlaw. Yet, science cannot formulate law. It is hoped that a philosophicalunderstanding of the relationships between science and law willcontribute to their constructively coming together in the service ofsociety.

  12. Genomes to Life Project Quartely Report October 2004.

    SciTech Connect (OSTI)

    Heffelfinger, Grant S.; Martino, Anthony; Rintoul, Mark Daniel; Geist, Al; Gorin, Andrey; Xu, Ying; Palenik, Brian

    2005-02-01

    This SAND report provides the technical progress through October 2004 of the Sandia-led project, %22Carbon Sequestration in Synechococcus Sp.: From Molecular Machines to Hierarchical Modeling,%22 funded by the DOE Office of Science Genomes to Life Program. Understanding, predicting, and perhaps manipulating carbon fixation in the oceans has long been a major focus of biological oceanography and has more recently been of interest to a broader audience of scientists and policy makers. It is clear that the oceanic sinks and sources of CO2 are important terms in the global environmental response to anthropogenic atmospheric inputs of CO2 and that oceanic microorganisms play a key role in this response. However, the relationship between this global phenomenon and the biochemical mechanisms of carbon fixation in these microorganisms is poorly understood. In this project, we will investigate the carbon sequestration behavior of Synechococcus Sp., an abundant marine cyanobacteria known to be important to environmental responses to carbon dioxide levels, through experimental and computational methods. This project is a combined experimental and computational effort with emphasis on developing and applying new computational tools and methods. Our experimental effort will provide the biology and data to drive the computational efforts and include significant investment in developing new experimental methods for uncovering protein partners, characterizing protein complexes, identifying new binding domains. We will also develop and apply new data measurement and statistical methods for analyzing microarray experiments. Computational tools will be essential to our efforts to discover and characterize the function of the molecular machines of Synechococcus. To this end, molecular simulation methods will be coupled with knowledge discovery from diverse biological data sets for high-throughput discovery and characterization of protein-protein complexes. In addition, we will develop a set of novel capabilities for inference of regulatory pathways in microbial genomes across multiple sources of information through the integration of computational and experimental technologies. These capabilities will be applied to Synechococcus regulatory pathways to characterize their interaction map and identify component proteins in these - 4 - pathways. We will also investigate methods for combining experimental and computational results with visualization and natural language tools to accelerate discovery of regulatory pathways. The ultimate goal of this effort is develop and apply new experimental and computational methods needed to generate a new level of understanding of how the Synechococcus genome affects carbon fixation at the global scale. Anticipated experimental and computational methods will provide ever-increasing insight about the individual elements and steps in the carbon fixation process, however relating an organism's genome to its cellular response in the presence of varying environments will require systems biology approaches. Thus a primary goal for this effort is to integrate the genomic data generated from experiments and lower level simulations with data from the existing body of literature into a whole cell model. We plan to accomplish this by developing and applying a set of tools for capturing the carbon fixation behavior of complex of Synechococcus at different levels of resolution. Finally, the explosion of data being produced by high-throughput experiments requires data analysis and models which are more computationally complex, more heterogeneous, and require coupling to ever increasing amounts of experimentally obtained data in varying formats. These challenges are unprecedented in high performance scientific computing and necessitate the development of a companion computational infrastructure to support this effort. More information about this project, including a copy of the original proposal, can be found at www.genomes-to-life.org Acknowledgment We want to gratefully acknowledge the contributions of the GTL Project Te

  13. Prokaryotic Genomes from Microbes Online Database

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Alm, Eric J.; Huang, Katherine H.; Price, Morgan N.; Koche, Richard P.; Keller, Keith; Dubchak, Inna L.; Arkin, Adam P.

    To describe the potential functions of genes, MicrobesOnline includes protein family analyses (from InterPro and COG), metabolic maps (from KEGG), links to research papers (from UniProt and PubMed), and operon predictions for every genome. To examine each gene's evolutionary history, MicrobesOnline includes precomputed phylogenetic trees for all the gene families. It displays gene trees with genomic context or it compares the gene tree to the species tree. The tools provided with MicrobesOnline allow users to: compute customized motifs, sequence alignments, and phylogenetic trees change expression patterns in metabolic maps annotate genes in various ways The database contains more than 430 genomes. A browse tree tool and a genome browser are available, along with specialized search capabilities. (Specialized Interface)

  14. Genomic definition of species. Revision 1

    SciTech Connect (OSTI)

    Crkvenjakov, R.; Dramanac, R.

    1992-06-01

    A genome is the sum total of the DNA sequences in the cells of an individual organism. The common usage that species possess genomes comes naturally to biochemists, who have shown that all protein and nucleic acid molecules are at the same time species and individual-specific, with minor individual variations being superimposed on a consensus sequence that is constant for a species. By extension, this property is attributed to the common features of DNA in the chromosomes of members of a given species and is called (species) genome. The definition of species based on chromosomes, genes, or genome common to its member organisms has been implied or mentioned in passing numerous times. Some population biologists think that members of species have similar ``homeostatic genotypes,`` which are to a degree resistant to mutation or environmental change in the production of a basic phenotype.

  15. Phytozome System for Comparative Plant Genomics

    Energy Science and Technology Software Center (OSTI)

    2011-09-27

    Phytozome is a joint project of the Department of Energy's Joint Genome Institute and the UC Berkeley Center for Integrative Genomics to facilitate comparative genomic studies amongst green plants. Families of orthologous and paralogous genes that represent the modern descendents of ancestral gene sets are constructed at key phylogenetic nodes. These families allow easy access to clade specific orthology/paralogy relationships as well as clade specific genes and gene expansions. As of release 7.0, Phytozome providesmore┬á┬╗ access to twenty-five sequenced and annotated green plant genomes which have been clustered into gene families at eleven evolutionarily significant nodes., Where possible, each gene has been annotated with PFAM, KOG, KEGG, and PANTHER assignments, and publicly available annotations from RefSeq, UniProt, TAIR, JGI are lyper-linked and searchable.┬ź┬áless

  16. Webinar December 2: Materials Genome Initiative

    Broader source: Energy.gov [DOE]

    The Energy Department will present a live webinar entitled "Materials Genome Initiative" on Tuesday, December 2, from 12:00 to 1:00 p.m. Eastern Standard Time.

  17. Justice and the Human Genome Project

    SciTech Connect (OSTI)

    Murphy, T.F.; Lappe, M.

    1992-12-31

    Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

  18. Justice and the Human Genome Project

    SciTech Connect (OSTI)

    Murphy, T.F.; Lappe, M.

    1992-01-01

    Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

  19. Genome Engineering with TAL Effector Nucleases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TAL Effector Nucleases Print Genome engineering (GE), an emerging discipline in which a DNA sequence is altered at a single position, has a wide variety of potential uses, such as...

  20. Comparative Genomics Analysis and Phenotypic Characterization...

    Office of Scientific and Technical Information (OSTI)

    of electron acceptors for respiration is due to the large number of c-type cytochrome genes present in the genome of Shewanella strains. More recently the dissimilatory metal...

  1. Genome Engineering with TAL Effector Nucleases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TAL Effector Nucleases Print Genome engineering (GE), an emerging discipline in which a DNA sequence is altered at a single position, has a wide variety of potential uses, such...

  2. Thomas Jefferson High School for Science & Technology National Science

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Bowl® Champion | Department of Energy Thomas Jefferson High School for Science & Technology National Science Bowl® Champion Thomas Jefferson High School for Science & Technology National Science Bowl® Champion May 2, 2005 - 12:40pm Addthis WASHINGTON, DC -- "The Incompleteness Theorem" was the answer to a question on mathematics that today clinched the 2005 National Science Bowl® championship for the Thomas Jefferson High School for Science & Technology team from

  3. Science on Tap - Matter

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science on Tap - Matter Science on Tap - Matter WHEN: Feb 18, 2016 5:30 PM - 7:00 PM WHERE: UnQuarked Wine Room 145 Central Park Square, Los Alamos, New Mexico 87544 USA SPEAKER: Jack Shlachter CONTACT: Linda Anderman (505) 665-9196 CATEGORY: Bradbury INTERNAL: Calendar Login Event Description Mark your calendars for this event held every third Thursday from 5:30 to 7 p.m. A short presentation is followed by a lively discussion on a different subject each month. What's the Matter with Matter?

  4. Bradbury Science Museum

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Kennedy memorabilia unveiled at Bradbury Science Museum April 19, 2011 LOS ALAMOS, New Mexico, April 19, 2011-For almost a half-century, no one except a handful of Los Alamos National Laboratory employees even knew it existed- a collection of lovingly preserved artifacts from President John F. Kennedy's 1962 visit to Los Alamos.For the first time, LANL is making the collection available to the public, who can see it until this August at the Bradbury Science Museum."We're fortunate that the

  5. Science and Society Colloquium

    ScienceCinema (OSTI)

    None

    2011-04-25

    Mr. Randi will give an update of his lecture to the American Physical Society on the occasion of his award of the 1989 Forum Prize. The citation said: "for his unique defense of Science and the scientific method in many disciplines, including physics, against pseudoscience, frauds and charlatans. His use of scientific techniques has contributed to refuting suspicious and fraudulent claims of paranormal results. He has contributed significantly to public understanding of important issues where science and society interact". He is a professional magician and author of many books. He worked with John Maddox, the Editor of Nature to investigate the claims of "water with memory".

  6. GNU Science Library (GSL)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GNU Science Library (GSL) GNU Science Library (GSL) Description GSL, a numerical library for C and C++ programmers, is available on Hopper, Edison, and Carver, and PDSF. How to Access GSL You must use the module utility to access the library on all machines at NERSC. To load: module load gsl To see what environment variables are defined by the library: module show gsl Using GSL on Cori and Edison On Cori or Edison if you want to use the gcc compiler and GSL you must swap the modulefiles for the

  7. Science@WIPP

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    At the dawn of discovery ... Science@WIPP The deep geologic repository at WIPP is more than a place to dispose of transuranic (TRU) waste ┬ľ it┬ĺs also a science laboratory. Following the designation of the Department of Energy┬ĺs Carlsbad office as a field office in 2000, numerous universities and research institutions across the nation sought to take advantage of WIPP┬ĺs strong safety culture, open door policy, and extremely low levels of natural background radiation in the underground. It┬ĺs

  8. Applied Science/Techniques

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Applied Science/Techniques Applied Science/Techniques Print The ALS is an excellent incubator of new scientific techniques and instrumentation. Many of the technical advances that make the ALS a world-class soft x-ray facility are developed at the ALS itself. The optical components in use at the ALS-mirrors and lenses optimized for x-ray wavelengths-require incredibly high-precision surfaces and patterns (often formed through extreme ultraviolet lithography at the ALS) and must undergo rigorous

  9. Facilities and Equipment for Genomics/Comparative Functional Genomics at New York University

    SciTech Connect (OSTI)

    Lennie, Peter

    2006-06-29

    This award was for partial support for the renovation of space to house research laboratories and moveable scientific equipment for genomics/functional geonomics at New York University.

  10. Accelerating Biofuel Feedstock Crop Improvement with Miscanthus Genomics (2014 DOE JGI Genomics of Energy & Environment Meeting)

    SciTech Connect (OSTI)

    Swaminathan, Kankshita

    2014-03-20

    Kankshita Swaminathan of the Energy Biosciences Institute speaks at the 9th Annual Genomics of Energy & Environment Meeting on March 20, 2014 in Walnut Creek, Calif.

  11. The Human Genome Diversity Project

    SciTech Connect (OSTI)

    Cavalli-Sforza, L.

    1994-12-31

    The Human Genome Diversity Project (HGD Project) is an international anthropology project that seeks to study the genetic richness of the entire human species. This kind of genetic information can add a unique thread to the tapestry knowledge of humanity. Culture, environment, history, and other factors are often more important, but humanity`s genetic heritage, when analyzed with recent technology, brings another type of evidence for understanding species` past and present. The Project will deepen the understanding of this genetic richness and show both humanity`s diversity and its deep and underlying unity. The HGD Project is still largely in its planning stages, seeking the best ways to reach its goals. The continuing discussions of the Project, throughout the world, should improve the plans for the Project and their implementation. The Project is as global as humanity itself; its implementation will require the kinds of partnerships among different nations and cultures that make the involvement of UNESCO and other international organizations particularly appropriate. The author will briefly discuss the Project`s history, describe the Project, set out the core principles of the Project, and demonstrate how the Project will help combat the scourge of racism.

  12. Standards for a new genomic era

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Standards for new genomic era Standards for a new genomic era A team of geneticists has recently proposed a set of standards designed to elucidate the quality of publicly available genetic sequencing information. October 21, 2009 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los

  13. Genome Engineering with TAL Effector Nucleases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genome Engineering with TAL Effector Nucleases Print Genome engineering (GE), an emerging discipline in which a DNA sequence is altered at a single position, has a wide variety of potential uses, such as the correction of gene sequences in patients suffering from genetic diseases, the modification or insertion of genes in plants, and the generation of unique cell lines for treatment of diseases such as cancer. GE requires the development of molecular tools that can search out and bind to one

  14. Genome Engineering with TAL Effector Nucleases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genome Engineering with TAL Effector Nucleases Print Genome engineering (GE), an emerging discipline in which a DNA sequence is altered at a single position, has a wide variety of potential uses, such as the correction of gene sequences in patients suffering from genetic diseases, the modification or insertion of genes in plants, and the generation of unique cell lines for treatment of diseases such as cancer. GE requires the development of molecular tools that can search out and bind to one

  15. Genome Engineering with TAL Effector Nucleases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genome Engineering with TAL Effector Nucleases Print Genome engineering (GE), an emerging discipline in which a DNA sequence is altered at a single position, has a wide variety of potential uses, such as the correction of gene sequences in patients suffering from genetic diseases, the modification or insertion of genes in plants, and the generation of unique cell lines for treatment of diseases such as cancer. GE requires the development of molecular tools that can search out and bind to one

  16. Genome Engineering with TAL Effector Nucleases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genome Engineering with TAL Effector Nucleases Print Genome engineering (GE), an emerging discipline in which a DNA sequence is altered at a single position, has a wide variety of potential uses, such as the correction of gene sequences in patients suffering from genetic diseases, the modification or insertion of genes in plants, and the generation of unique cell lines for treatment of diseases such as cancer. GE requires the development of molecular tools that can search out and bind to one

  17. Materials Genome Initiative | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Emerging Technologies ┬╗ Materials Genome Initiative Materials Genome Initiative Credit: The White House Credit: The White House Lead Performers: -- National Renewable Energy Laboratory - Golden, CO -- Lawrence Berkeley National Laboratory - Berkeley, CA Project Term: October 2014 to July 2015 Project Background The development of new higher performing materials for buildings and building systems will be a key element of making the high-efficiency, high-performing buildings of the future. The

  18. ASCR Science Network Requirements

    SciTech Connect (OSTI)

    Dart, Eli; Tierney, Brian

    2009-08-24

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the US Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In April 2009 ESnet and the Office of Advanced Scientific Computing Research (ASCR), of the DOE Office of Science, organized a workshop to characterize the networking requirements of the programs funded by ASCR. The ASCR facilities anticipate significant increases in wide area bandwidth utilization, driven largely by the increased capabilities of computational resources and the wide scope of collaboration that is a hallmark of modern science. Many scientists move data sets between facilities for analysis, and in some cases (for example the Earth System Grid and the Open Science Grid), data distribution is an essential component of the use of ASCR facilities by scientists. Due to the projected growth in wide area data transfer needs, the ASCR supercomputer centers all expect to deploy and use 100 Gigabit per second networking technology for wide area connectivity as soon as that deployment is financially feasible. In addition to the network connectivity that ESnet provides, the ESnet Collaboration Services (ECS) are critical to several science communities. ESnet identity and trust services, such as the DOEGrids certificate authority, are widely used both by the supercomputer centers and by collaborations such as Open Science Grid (OSG) and the Earth System Grid (ESG). Ease of use is a key determinant of the scientific utility of network-based services. Therefore, a key enabling aspect for scientists beneficial use of high performance networks is a consistent, widely deployed, well-maintained toolset that is optimized for wide area, high-speed data transfer (e.g. GridFTP) that allows scientists to easily utilize the services and capabilities that the network provides. Network test and measurement is an important part of ensuring that these tools and network services are functioning correctly. One example of a tool in this area is the recently developed perfSONAR, which has already shown its usefulness in fault diagnosis during the recent deployment of high-performance data movers at NERSC and ORNL. On the other hand, it is clear that there is significant work to be done in the area of authentication and access control - there are currently compatibility problems and differing requirements between the authentication systems in use at different facilities, and the policies and mechanisms in use at different facilities are sometimes in conflict. Finally, long-term software maintenance was of concern for many attendees. Scientists rely heavily on a large deployed base of software that does not have secure programmatic funding. Software packages for which this is true include data transfer tools such as GridFTP as well as identity management and other software infrastructure that forms a critical part of the Open Science Grid and the Earth System Grid.

  19. Microbial Protein-Protein Interactions (MiPPI) Data from the Genomics: GTL Center for Molecular and Cellular Systems (CMCS)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The Genomic Science Center for Molecular and Cellular Systems (CMCS), established in 2002, seeks to identify and characterize the complete set of protein complexes within a cell to provide a mechanistic basis for the understanding of biochemical functions. The CMCS is anchored at ORNL and PNNL. CMCS initially focused on the identification and characterization of protein complexes in two microbial systems,Rhodopseudomonas palustris (R. palustris) and Shewanella oneidensis (S. oneidensis). These two organisms have also been the focus of major DOE Genomic Science/Microbial Cell Program (MCP) projects. To develop an approach for identifying the diverse types of complexes present in microbial organisms, CMCS incorporates a number of molecular biology, microbiology, analytical and computational tools in an integrated pipeline.

  20. Los Alamos ScienceFest

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Los Alamos ScienceFest Los Alamos ScienceFest WHEN: Jul 16, 2015 12:00 AM - Jul 18, 2015 6:00 PM WHERE: Los Alamos, New Mexico CONTACT: Jessica Privette 505 667-0375 CATEGORY: Bradbury INTERNAL: Calendar Login Los Alamos ScienceFest July 16-18, 2015 Event Description A 3-day science festival running July 16-18, 2015 Bradbury Events @ Los Alamos ScienceFest Join us during Los Alamos ScienceFest!-a 3-day festival of interactive demonstrations, hands-on activities and dynamic speakers meant to

  1. JLF Science Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Publications 2015 2014 2013 2012 2011 2010 2009 2008 2007 2003-06 Title Author Source Date Title Author Source Date Title Author Source Date Title Author Source Date Title Author Source Date Title Author Source Date Title Author Source Date Title Author Source Date Title Author Source Date Title Author Source Date

  2. Science on Saturday attracts science fans of all ages | Princeton...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science on Saturday attracts science fans of all ages By Jeanne Jackson DeVoe January 28, 2013 Tweet Widget Google Plus One Share on Facebook Joshua E. G. Peek, a Hubble Fellow at...

  3. Science Highlights | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Science Highlights Chemical Sciences, Geosciences, & Biosciences (CSGB) Division CSGB Home About Research Areas Reports and Activities Science Highlights Highlight Archives Principal Investigators' Meetings BES Home Science Highlights Print Text Size: A A A FeedbackShare Page Filter by Performer Or press Esc Key to close. close Select all that apply. University DOE Laboratory Industry SC User Facilities ASCR User Facilities [+] Options ┬ź ASCR User Facilities National Energy Research

  4. Science Highlights | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Science Highlights Materials Sciences and Engineering (MSE) Division MSE Home About Research Areas Reports and Activities Science Highlights Highlight Archives Principal Investigators' Meetings BES Home Science Highlights Print Text Size: A A A FeedbackShare Page Filter by Performer Or press Esc Key to close. close Select all that apply. University DOE Laboratory Industry SC User Facilities ASCR User Facilities [+] Options ┬ź ASCR User Facilities National Energy Research Scientific Computing

  5. Science Highlights | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Highlights User Facilities User Facilities Home User Facilities at a Glance User Resources User Statistics Policies and Processes Science Highlights Frequently Asked Questions User Facility News Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 Science Highlights Print Text Size: A A A Subscribe FeedbackShare Page Filter by Program Or press Esc Key to close. close Select all that apply. Advanced Scientific

  6. Science Highlights | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Sciences Laboratory (EMSL) Atmospheric Radiation Measurement Climate Research Facility ... Read More Data collected from the Atmospheric Radiation Measurement Climate Research ...

  7. Integrated Microbial Genomes (IMG) System from the DOE Joint Genome Institute (JGI)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The integrated microbial genomes (IMG) system is a data management, analysis and annotation platform for all publicly available genomes. IMG contains both draft and complete JGI microbial genomes integrated with all other publicly available genomes from all three domains of life, together with a large number of plasmids and viruses. IMG provides tools and viewers for analyzing and annotating genomes, genes and functions, individually or in a comparative context. Since its first release in 2005, IMG's data content and analytical capabilities have been constantly expanded through quarterly releases. IMG is provided by the DOE-Joint Genome Institute (JGI) and is available from http://img.jgi.doe.gov. [Abstract from The integrated microbial genomes (IMG) system in 2007: data content and analysis tool extensions; Victor M. Markowitz, Ernest Szeto, Krishna Palaniappan, Yuri Grechkin, Ken Chu, I-Min A. Chen, Inna Dubchak, Iain Anderson, Athanasios Lykidis, Konstantinos Mavromatis, Natalia N. Ivanova and Nikos C. Kyrpides; Nucleic Acids Research, 2008, Vol. 36. (Database Issue) See also the companion system, Integrated Microbial Genomes with Microbiome Samples.

  8. Science Olympiad | Photosynthetic Antenna Research Center

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Olympiad Science Olympiad PARC's outreach efforts helped fund students from KIPP Inspire Academy as they competed with other regional schools in the Science Olympiad 2013...

  9. Enforcement Letter, Brookhaven Science Associates - January 16...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Science Associates - January 16, 2002 Enforcement Letter, Brookhaven Science Associates - January 16, 2002 January 16, 2002 Issued to Brookhaven Science Associates related to...

  10. Division Director, Chemical Sciences, Geosciences and Biosciences

    Broader source: Energy.gov [DOE]

    The Department of Energy, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences and Biosciences Division is seeking a motivated and highly qualified individual to...

  11. Principal Associate Director - Science, Technology, and Engineering

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science, Technology, and Engineering As Principal Associate Director for Science, Technology, and Engineering, Alan Bishop leads programs to ensure a world-class science and...

  12. Integrating Information, Science, and Technology for Prediction

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Integrating Information, Science, and Technology for Prediction Integrating Information, Science, and Technology for Prediction (IS&T) The Lab's four Science Pillars harness...

  13. Science Frontiers Pacific Northwest National Laboratory (PNNL...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Frontiers Pacific Northwest National Laboratory (PNNL), a U.S. Department of Energy Office of Science Laboratory, is pushing the frontiers of science in areas that are...

  14. Genome sequence analysis of the model grass Brachypodium distachyon: insights into grass genome evolution

    SciTech Connect (OSTI)

    Schulman, Al

    2009-08-09

    Three subfamilies of grasses, the Erhardtoideae (rice), the Panicoideae (maize, sorghum, sugar cane and millet), and the Pooideae (wheat, barley and cool season forage grasses) provide the basis of human nutrition and are poised to become major sources of renewable energy. Here we describe the complete genome sequence of the wild grass Brachypodium distachyon (Brachypodium), the first member of the Pooideae subfamily to be completely sequenced. Comparison of the Brachypodium, rice and sorghum genomes reveals a precise sequence- based history of genome evolution across a broad diversity of the grass family and identifies nested insertions of whole chromosomes into centromeric regions as a predominant mechanism driving chromosome evolution in the grasses. The relatively compact genome of Brachypodium is maintained by a balance of retroelement replication and loss. The complete genome sequence of Brachypodium, coupled to its exceptional promise as a model system for grass research, will support the development of new energy and food crops

  15. GenomePeekÔÇöan online tool for prokaryotic genome and metagenome analysis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    McNair, Katelyn; Edwards, Robert A.

    2015-06-16

    As increases in prokaryotic sequencing take place, a method to quickly and accurately analyze this data is needed. Previous tools are mainly designed for metagenomic analysis and have limitations; such as long runtimes and significant false positive error rates. The online tool GenomePeek (edwards.sdsu.edu/GenomePeek) was developed to analyze both single genome and metagenome sequencing files, quickly and with low error rates. GenomePeek uses a sequence assembly approach where reads to a set of conserved genes are extracted, assembled and then aligned against the highly specific reference database. GenomePeek was found to be faster than traditional approaches while still keeping errormore┬á┬╗ rates low, as well as offering unique data visualization options.┬ź┬áless

  16. Genomic Sequence or Signature Tags (GSTs) from the Genome Group at Brookhaven National Laboratory (BNL)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Dunn, John J.; McCorkle, Sean R.; Praissman, Laura A.; Hind, Geoffrey; Van der Lelie, Daniel; Bahou, Wadie F.; Gnatenko, Dmitri V.; Krause, Maureen K.

    Genomic Signature Tags (GSTs) are the products of a method we have developed for identifying and quantitatively analyzing genomic DNAs. The DNA is initially fragmented with a type II restriction enzyme. An oligonucleotide adaptor containing a recognition site for MmeI, a type IIS restriction enzyme, is then used to release 21-bp tags from fixed positions in the DNA relative to the sites recognized by the fragmenting enzyme. These tags are PCR-amplified, purified, concatenated and then cloned and sequenced. The tag sequences and abundances are used to create a high resolution GST sequence profile of the genomic DNA. [Quoted from Genomic Signature Tags (GSTs): A System for Profiling Genomic DNA, Dunn, John J.; McCorkle, Sean R.; Praissman, Laura A.; Hind, Geoffrey; Van der Lelie, Daniel; Bahou, Wadie F.; Gnatenko, Dmitri V.; Krause, Maureen K., Revised 9/13/2002

  17. Frontiers in Science Lecture Series

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Video Resources ┬╗ Frontiers in Science Lecture Series Frontiers in Science Lecture Series The Laboratory Fellows are appointed by the Laboratory Director in recognition of sustained outstanding contributions and exceptional promise for continued professional achievement. The Frontiers in Science series shares the Laboratory's cutting-edge research with the surrounding community. Contact Communications Office (505)665-9196 or (505)667-7000 Frontiers in Science Lecture Series Presented by the Los

  18. ARM - RHUBC II Science Objectives

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Objectives Related Links RHUBC-II Home RHUBC Home ARM Field Campaigns Home ARM Data Discovery Browse Data Deployment Instruments Science Team RHUBC-II Wiki Site Tour News RHUBC-II Backgrounder (PDF, 300K) News & Press Images Experiment Planning RHUBC-II Proposal Abstract Science Plan (PDF, 267KB) Science Objectives Contacts Eli Mlawer, Principal Investigator Dave Turner, Principal Investigator RHUBC II Science Objectives To conduct clear-sky radiative closure studies in order to reduce the

  19. ARM - RHUBC II Science Team

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Team Related Links RHUBC-II Home RHUBC Home ARM Field Campaigns Home ARM Data Discovery Browse Data Deployment Instruments Science Team RHUBC-II Wiki Site Tour News RHUBC-II Backgrounder (PDF, 300K) News & Press Images Experiment Planning RHUBC-II Proposal Abstract Science Plan (PDF, 267KB) Science Objectives Contacts Eli Mlawer, Principal Investigator Dave Turner, Principal Investigator RHUBC II Science Team Principal Investigators Eli Mlawer, Atmospheric & Environmental Research, Inc.

  20. Inspiring Careers in Science Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Inspiring Careers in Science Research Inspiring Careers in Science Research January 21, 2012 Lowell-3_2.JPG David Turner shows Lowell High School students around NERSC's computer room. (Photo by Margie Wylie) In an effort to expose high school students to careers in research, the Lawrence Berkeley National Laboratory's (Berkeley Lab) Computing Sciences Diversity Outreach Program partnered with San Francisco's Lowell High School Science Research Program, an after school program that aims to give

  1. Science Highlights | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Highlights Topic - Any - General Argonne Information -Awards -Honors Energy -Energy efficiency --Vehicles ---Alternative fuels ---Automotive engineering ---Biofuels...

  2. NIF & Photon Science Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NIF & Photon Science Management The management team for the NIF & Photon Science Principal Directorate supports the directorate's key mission areas: Stockpile Stewardship, national security applications, NIF Discovery Science, laser-based directed energy and related laser and optical technologies, and advanced photon technologies. Directorate Programs Jeff Wisoff Principal Associate Director NIF & Photon Science Jeff Atherton Principal Deputy Principal Associate Director NIF &

  3. Lab supports multiethnic science careers

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    supports multiethnic science careers Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue:Mar. 2016 all issues All Issues ┬╗ submit Lab supports multi-ethnic science careers Pilot program prepares regional students for national conference November 1, 2013 Society for Advancement of Chicanos and Native Americans in Science Society for Advancement of Chicanos and Native Americans in Science Contact Community Programs Office Director Kurt

  4. Los Alamos Neutron Science Center

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    capacity and our availability for stockpile stewardship activities," said Kurt Schoenberg, deputy associate director for Experimental Physical Sciences. "The increased...

  5. Environmental Science | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Science & Innovation » Science & Technology » Environmental Science Environmental Science A revolutionary new turbine technology for hydropower plants is one step closer to its first commercial deployment. At peak performance, an Alden turbine should convert about 94 percent of the water’s energy into usable electricity, comparable or superior to the efficiency of traditional turbines; the overall wildlife survival rate should be over 98 percent, up from 80-85 percent for a

  6. Understanding our genetic inheritance: The US Human Genome Project, The first five years FY 1991--1995

    SciTech Connect (OSTI)

    1990-04-01

    The Human Genome Initiative is a worldwide research effort with the goal of analyzing the structure of human DNA and determining the location of the estimated 100,000 human genes. In parallel with this effort, the DNA of a set of model organisms will be studied to provide the comparative information necessary for understanding the functioning of the human genome. The information generated by the human genome project is expected to be the source book for biomedical science in the 21st century and will by of immense benefit to the field of medicine. It will help us to understand and eventually treat many of the more than 4000 genetic diseases that affect mankind, as well as the many multifactorial diseases in which genetic predisposition plays an important role. A centrally coordinated project focused on specific objectives is believed to be the most efficient and least expensive way of obtaining this information. The basic data produced will be collected in electronic databases that will make the information readily accessible on convenient form to all who need it. This report describes the plans for the U.S. human genome project and updates those originally prepared by the Office of Technology Assessment (OTA) and the National Research Council (NRC) in 1988. In the intervening two years, improvements in technology for almost every aspect of genomics research have taken place. As a result, more specific goals can now be set for the project.

  7. Understanding our Genetic Inheritance: The U.S. Human Genome Project, The First Five Years FY 1991--1995

    DOE R&D Accomplishments [OSTI]

    1990-04-01

    The Human Genome Initiative is a worldwide research effort with the goal of analyzing the structure of human DNA and determining the location of the estimated 100,000 human genes. In parallel with this effort, the DNA of a set of model organisms will be studied to provide the comparative information necessary for understanding the functioning of the human genome. The information generated by the human genome project is expected to be the source book for biomedical science in the 21st century and will by of immense benefit to the field of medicine. It will help us to understand and eventually treat many of the more than 4000 genetic diseases that affect mankind, as well as the many multifactorial diseases in which genetic predisposition plays an important role. A centrally coordinated project focused on specific objectives is believed to be the most efficient and least expensive way of obtaining this information. The basic data produced will be collected in electronic databases that will make the information readily accessible on convenient form to all who need it. This report describes the plans for the U.S. human genome project and updates those originally prepared by the Office of Technology Assessment (OTA) and the National Research Council (NRC) in 1988. In the intervening two years, improvements in technology for almost every aspect of genomics research have taken place. As a result, more specific goals can now be set for the project.

  8. To Know Ourselves: The U.S. Department of Energy and The Human Genome Project

    DOE R&D Accomplishments [OSTI]

    1996-07-01

    The Genome Project and its various aspects: why the DOE?; introducing the human genome; exploring the genomic landscape; beyond biology; and ethical, legal, and social implications.

  9. VISTA - computational tools for comparative genomics

    SciTech Connect (OSTI)

    Frazer, Kelly A.; Pachter, Lior; Poliakov, Alexander; Rubin,Edward M.; Dubchak, Inna

    2004-01-01

    Comparison of DNA sequences from different species is a fundamental method for identifying functional elements in genomes. Here we describe the VISTA family of tools created to assist biologists in carrying out this task. Our first VISTA server at http://www-gsd.lbl.gov/VISTA/ was launched in the summer of 2000 and was designed to align long genomic sequences and visualize these alignments with associated functional annotations. Currently the VISTA site includes multiple comparative genomics tools and provides users with rich capabilities to browse pre-computed whole-genome alignments of large vertebrate genomes and other groups of organisms with VISTA Browser, submit their own sequences of interest to several VISTA servers for various types of comparative analysis, and obtain detailed comparative analysis results for a set of cardiovascular genes. We illustrate capabilities of the VISTA site by the analysis of a 180 kilobase (kb) interval on human chromosome 5 that encodes for the kinesin family member3A (KIF3A) protein.

  10. Genomes to life project quarterly report June 2004.

    SciTech Connect (OSTI)

    Heffelfinger, Grant S.

    2005-01-01

    This SAND report provides the technical progress through June 2004 of the Sandia-led project, ''Carbon Sequestration in Synechococcus Sp.: From Molecular Machines to Hierarchical Modeling'', funded by the DOE Office of Science Genomes to Life Program. Understanding, predicting, and perhaps manipulating carbon fixation in the oceans has long been a major focus of biological oceanography and has more recently been of interest to a broader audience of scientists and policy makers. It is clear that the oceanic sinks and sources of CO{sub 2} are important terms in the global environmental response to anthropogenic atmospheric inputs of CO{sub 2} and that oceanic microorganisms play a key role in this response. However, the relationship between this global phenomenon and the biochemical mechanisms of carbon fixation in these microorganisms is poorly understood. In this project, we will investigate the carbon sequestration behavior of Synechococcus Sp., an abundant marine cyanobacteria known to be important to environmental responses to carbon dioxide levels, through experimental and computational methods. This project is a combined experimental and computational effort with emphasis on developing and applying new computational tools and methods. Our experimental effort will provide the biology and data to drive the computational efforts and include significant investment in developing new experimental methods for uncovering protein partners, characterizing protein complexes, identifying new binding domains. We will also develop and apply new data measurement and statistical methods for analyzing microarray experiments. Computational tools will be essential to our efforts to discover and characterize the function of the molecular machines of Synechococcus. To this end, molecular simulation methods will be coupled with knowledge discovery from diverse biological data sets for high-throughput discovery and characterization of protein-protein complexes. In addition, we will develop a set of novel capabilities for inference of regulatory pathways in microbial genomes across multiple sources of information through the integration of computational and experimental technologies. These capabilities will be applied to Synechococcus regulatory pathways to characterize their interaction map and identify component proteins in these pathways. We will also investigate methods for combining experimental and computational results with visualization and natural language tools to accelerate discovery of regulatory pathways. The ultimate goal of this effort is develop and apply new experimental and computational methods needed to generate a new level of understanding of how the Synechococcus genome affects carbon fixation at the global scale. Anticipated experimental and computational methods will provide ever-increasing insight about the individual elements and steps in the carbon fixation process, however relating an organism's genome to its cellular response in the presence of varying environments will require systems biology approaches. Thus a primary goal for this effort is to integrate the genomic data generated from experiments and lower level simulations with data from the existing body of literature into a whole cell model. We plan to accomplish this by developing and applying a set of tools for capturing the carbon fixation behavior of complex of Synechococcus at different levels of resolution. Finally, the explosion of data being produced by high-throughput experiments requires data analysis and models which are more computationally complex, more heterogeneous, and require coupling to ever increasing amounts of experimentally obtained data in varying formats. These challenges are unprecedented in high performance scientific computing and necessitate the development of a companion computational infrastructure to support this effort.

  11. Physical mapping of complex genomes

    DOE Patents [OSTI]

    Evans, G.A.

    1993-06-15

    A method for the simultaneous identification of overlapping cosmid clones among multiple cosmid clones and the use of the method for mapping complex genomes are provided. A library of cosmid clones that contains the DNA to be mapped is constructed and arranged in a manner such that individual clones can be identified and replicas of the arranged clones prepared. In preferred embodiments, the clones are arranged in a two dimensional matrix. In such embodiments, the cosmid clones in a row are pooled, mixed probes complementary to the ends of the DNA inserts in the pooled clones are synthesized, hybridized to a first replica of the library. Hybridizing clones, which include the pooled row, are identified. A second portion of clones is prepared by pooling cosmid clones that correspond to a column in the matrix. The second pool thereby includes one clone from the first portion pooled clones. This common clone is located on the replica at the intersection of the column and row. Mixed probes complementary to the ends of the DNA inserts in the second pooled portion of clones are prepared and hybridized to a second replica of the library. The hybridization pattern on the first and second replicas of the library are compared and cross-hybridizing clones, other than the clones in the pooled column and row, that hybridize to identical clones in the first and second replicas are identified. These clones necessarily include DNA inserts that overlap with the DNA insert in the common clone located at the intersection of the pooled row and pooled column. The DNA in the entire library may be mapped by pooling the clones in each of the rows and columns of the matrix, preparing mixed end-specific probes and hybridizing the probes from each row or column to a replica of the library. Since all clones in the library are located at the intersection of a column and a row, the overlapping clones for all clones in the library may be identified and a physical map constructed.

  12. Physical mapping of complex genomes

    DOE Patents [OSTI]

    Evans, Glen A. (Encinitas, CA)

    1993-01-01

    Method for simultaneous identification of overlapping cosmid clones among multiple cosmid clones and the use of the method for mapping complex genomes are provided. A library of cosmid clones that contains the DNA to be mapped is constructed and arranged in a manner such that individual clones can be identified and replicas of the arranged clones prepared. In preferred embodiments, the clones are arranged in a two dimensional matrix. In such embodiments, the cosmid clones in a row are pooled, mixed probes complementary to the ends of the DNA inserts int he pooled clones are synthesized, hybridized to a first replica of the library. Hybridizing clones, which include the pooled row, are identified. A second portion of clones is prepared by pooling cosmid clones that correspond to a column in the matrix. The second pool thereby includes one clone from the first portion pooled clones. This common clone is located on the replica at the intersection of the column and row. Mixed probes complementary to the ends of the DNA inserts in the second pooled portion of clones are prepared and hybridized to a second replica of the library. The hybridization pattern on the first and second replicas of the library are compared and cross-hybridizing clones, other than the clones in the pooled column and row, that hybridize to identical clones in the first and second replicas are identified. These clones necessarily include DNA inserts that overlap with the DNA insert int he common clone located at the intersection of the pooled row and pooled column. The DNA in the entire library may be mapped by pooling the clones in each of the rows and columns of the matrix, preparing mixed end-specific probes and hybridizing the probes from each row or column to a replica of the library. Since all clones in the library are located at the intersection of a column and a row, the overlapping clones for all clones in the library may be identified and a physical map constructed. In other preferred embodiments, the cosmid clones are arranged in a three dimensional matrix, pooled and compared in threes according to intersecting planes of the three dimensional matrix. Arrangements corresponding to geometries of higher dimensions may also be prepared and used to simultaneously identify overlapping clones in highly complex libraries with relatively few hybridization reactions.

  13. Science & Technology - 2014

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    technology Science & Technology - 2014 December Guiding Intense Laser Pulses Through Thin Air Measuring NIF's Enormous Shocks November Vital NIF Diagnostic Upgraded Adding Radiant Heating Capability to NASA's Heat-Shield Research October LLNL to Play Key Role in 10-Petawatt Laser Project LLNL's Phase-Shifting Diffraction Interferometer Has Many Uses September Demand Grows for NIF's Versatile X-ray Spectrometer August First Multi-bunch Operation from a Compact X-band Accelerator Tracking NIF

  14. Art and Science

    ScienceCinema (OSTI)

    Murray Gibson

    2010-01-08

    Argonne's Murray Gibson is a physicist whose life's work includes finding patterns among atoms. The love of distinguishing patterns also drives Gibson as a musician and Blues enthusiast.Both artists and scientists rely on the principles of mathematics and physics, whether consciously or intuitively, to achieve their goals.And, at the same time, both science and art rely on the creative questioner to ask, "Why do we do it this way?" and "Why not try something else and see what happens?"

  15. Applied Computer Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ADTSC ┬╗ CCS ┬╗ CCS-7 Applied Computer Science Innovative co-design of applications, algorithms, and architectures in order to enable scientific simulations at extreme scale Leadership Group Leader Linn Collins Email Deputy Group Leader (Acting) Bryan Lally Email Climate modeling visualization Results from a climate simulation computed using the Model for Prediction Across Scales (MPAS) code. This visualization shows the temperature of ocean currents using a green and blue color scale. These

  16. Environmental Science - Electro Lesson

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Liz Hudd Unit Title: Subject: Environmental Science Lesson Title: Electro Grade Level(s): 11/12 Lesson Length: Date(s): July 2014 * Learning Goal(s) [What should students know, understand, or be able to do as a result of this lab or activity.] Students will explore energy policy and decision making around balancing the various aspects of city development and energy consumption. * Energy Connection [How is this lesson connected to energy or renewable energy concepts.] Exploring the different

  17. Earth Sciences Research Center

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences Research Center - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs Advanced

  18. Materials Sciences and Engineering

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences and Engineering - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs Advanced

  19. New Science Developments | JCESR

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Science Developments Lawrence Berkeley National Laboratory's scientist Anna Javier prepares a sample for transmission electron microscopy imaging using a microtome in a battery lab at Berkeley Lab's Environmental Energy Technologies Division. Berkeley Lab is one of several major U.S. research institutions and industrial firms that form the Joint Center for Energy Storage Research, a public-private partnership that aims to overcome critical scientific and technical barriers and create new

  20. Fermilab | Science | Particle Accelerators

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Particle Accelerators PXIE As America's particle physics laboratory, Fermilab operates and builds powerful particle accelerators for investigating the smallest things human beings have ever observed. About 2,300 physicists from all over the world come to Fermilab to conduct experiments using particle accelerators. These machines not only drive discovery, they are themselves the subjects of research and innovation. Scientists and engineers at Fermilab actively advance accelerator science and

  1. Basic Energy Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs Advanced Nuclear Energy

  2. Health Detectives: Uncovering the Mysteries of Disease (LBNL Science at the Theater)

    ScienceCinema (OSTI)

    Bissell, Mina; Canaria, Christie; Celnicker, Susan; Karpen, Gary

    2014-05-06

    In this April 23, 2012 Science at the Theater event, Berkeley Lab scientists discuss how they uncover the mysteries of disease in unlikely places. Speakers and topics include: World-renowned cancer researcher Mina Bissell's pioneering research on the role of the cellular microenvironment in breast cancer has changed the conversation about the disease. How does DNA instability cause disease? To find out, Christie Canaria images neural networks to study disorders such as Huntington's disease. Fruit flies can tell us a lot about ourselves. Susan Celniker explores the fruit fly genome to learn how our genome works. DNA is not destiny. Gary Karpen explores how environmental factors shape genome function and disease through epigenetics.

  3. Science DMZ for Pennsylvania State University & Virginia Tech...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Penn & VTTI Science Engagement Move your data Programs & Workshops Science Requirements Reviews Case Studies OSCARS Case Studies Science DMZ Case Studies Science DMZ @ UF Science...

  4. Sequencing and comparing whole mitochondrial genomes ofanimals

    SciTech Connect (OSTI)

    Boore, Jeffrey L.; Macey, J. Robert; Medina, Monica

    2005-04-22

    Comparing complete animal mitochondrial genome sequences is becoming increasingly common for phylogenetic reconstruction and as a model for genome evolution. Not only are they much more informative than shorter sequences of individual genes for inferring evolutionary relatedness, but these data also provide sets of genome-level characters, such as the relative arrangements of genes, that can be especially powerful. We describe here the protocols commonly used for physically isolating mtDNA, for amplifying these by PCR or RCA, for cloning,sequencing, assembly, validation, and gene annotation, and for comparing both sequences and gene arrangements. On several topics, we offer general observations based on our experiences to date with determining and comparing complete mtDNA sequences.

  5. Genomic Evolution of the Ascomycete Yeasts

    SciTech Connect (OSTI)

    Riley, Robert; Haridas, Sajeet; Salamov, Asaf; Boundy-Mills, Kyria; Goker, Markus; Hittinger, Chris; Klenk, Hans-Peter; Lopes, Mariana; Meir-Kolthoff, Jan P.; Rokas, Antonis; Rosa, Carlos; Scheuner, Carmen; Soares, Marco; Stielow, Benjamin; Wisecaver, Jennifer H.; Wolfe, Ken; Blackwell, Meredith; Kurtzman, Cletus; Grigoriev, Igor; Jeffries, Thomas

    2015-03-16

    Yeasts are important for industrial and biotechnological processes and show remarkable metabolic and phylogenetic diversity despite morphological similarities. We have sequenced the genomes of 16 ascomycete yeasts of taxonomic and industrial importance including members of Saccharomycotina and Taphrinomycotina. Phylogenetic analysis of these and previously published yeast genomes helped resolve the placement of species including Saitoella complicata, Babjeviella inositovora, Hyphopichia burtonii, and Metschnikowia bicuspidata. Moreover, we find that alternative nuclear codon usage, where CUG encodes serine instead of leucine, are monophyletic within the Saccharomycotina. Most of the yeasts have compact genomes with a large fraction of single exon genes, and a tendency towards more introns in early-diverging species. Analysis of enzyme phylogeny gives insights into the evolution of metabolic capabilities such as methanol utilization and assimilation of alternative carbon sources.

  6. Justice and the human genome project

    SciTech Connect (OSTI)

    Murphy, T.F.; Lappe, M.A.

    1995-04-01

    This book is a collection of nine essays originally presented at a conference entitled {open_quotes}Justice and the Human Genome{close_quotes} held in Chicago in late 1991. The goal of the articles in this collection is to explore questions of justice raised by developments in genomic research and by applications of genetic knowledge and technology. The Human Genome Project (HGP) is used as a starting point for exploring these questions, but, as Marc Lappe recognizes, the database generated by HGP research will have implications far beyond the medical applications frequently used to justify this research effort. Thus, the book`s contributors consider questions of justice in relation to screening and testing for various predispositions, conditions, and diseases and gene therapy but also examine testing for other characteristics, forensic uses of genetic information, issues associated with DNA banks, and (hypothetical) genetic enhancement possibilities.

  7. Science on Saturday @ Lawrence Livermore Lab

    Broader source: Energy.gov [DOE]

    Science on Saturday. Science on Saturday (SOS) is a series of science lectures for middle and high school students. Each topic highlights cutting-edge science occurring at the Lawrence Livermore...

  8. Enabling Graph Appliance for Genome Assembly

    SciTech Connect (OSTI)

    Singh, Rina; Graves, Jeffrey A; Lee, Sangkeun; Sukumar, Sreenivas R; Shankar, Mallikarjun

    2015-01-01

    In recent years, there has been a huge growth in the amount of genomic data available as reads generated from various genome sequencers. The number of reads generated can be huge, ranging from hundreds to billions of nucleotide, each varying in size. Assembling such large amounts of data is one of the challenging computational problems for both biomedical and data scientists. Most of the genome assemblers developed have used de Bruijn graph techniques. A de Bruijn graph represents a collection of read sequences by billions of vertices and edges, which require large amounts of memory and computational power to store and process. This is the major drawback to de Bruijn graph assembly. Massively parallel, multi-threaded, shared memory systems can be leveraged to overcome some of these issues. The objective of our research is to investigate the feasibility and scalability issues of de Bruijn graph assembly on Cray s Urika-GD system; Urika-GD is a high performance graph appliance with a large shared memory and massively multithreaded custom processor designed for executing SPARQL queries over large-scale RDF data sets. However, to the best of our knowledge, there is no research on representing a de Bruijn graph as an RDF graph or finding Eulerian paths in RDF graphs using SPARQL for potential genome discovery. In this paper, we address the issues involved in representing a de Bruin graphs as RDF graphs and propose an iterative querying approach for finding Eulerian paths in large RDF graphs. We evaluate the performance of our implementation on real world ebola genome datasets and illustrate how genome assembly can be accomplished with Urika-GD using iterative SPARQL queries.

  9. Multiple Whole Genome Alignments Without a Reference Organism

    SciTech Connect (OSTI)

    Dubchak, Inna; Poliakov, Alexander; Kislyuk, Andrey; Brudno, Michael

    2009-01-16

    Multiple sequence alignments have become one of the most commonly used resources in genomics research. Most algorithms for multiple alignment of whole genomes rely either on a reference genome, against which all of the other sequences are laid out, or require a one-to-one mapping between the nucleotides of the genomes, preventing the alignment of recently duplicated regions. Both approaches have drawbacks for whole-genome comparisons. In this paper we present a novel symmetric alignment algorithm. The resulting alignments not only represent all of the genomes equally well, but also include all relevant duplications that occurred since the divergence from the last common ancestor. Our algorithm, implemented as a part of the VISTA Genome Pipeline (VGP), was used to align seven vertebrate and sixDrosophila genomes. The resulting whole-genome alignments demonstrate a higher sensitivity and specificity than the pairwise alignments previously available through the VGP and have higher exon alignment accuracy than comparable public whole-genome alignments. Of the multiple alignment methods tested, ours performed the best at aligning genes from multigene families?perhaps the most challenging test for whole-genome alignments. Our whole-genome multiple alignments are available through the VISTA Browser at http://genome.lbl.gov/vista/index.shtml.

  10. Genomic Data and Annotation from the SEED

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Fonstein, Michael; Kogan, Yakov; Osterman, Andrei; Overbeek, Ross; Vonstein, Veronika The Fellowship for Interpretation of Genomes (FIG)

    The SEED Project has been extended to support metagenomic samples and concomitant analytical tools. Moreover, the number of genomes being introduced into SEED is growing very rapidly. Building a framework to support this growth while providing highly accurate annotations is centrally important to SEED. The projectÔÇÖs subsystem-based annotation strategy has become the technological foundation for addressing these challenges.(copied from Appendix 7 of Systems Biology Knowledgebase for a New Era in Biology, A Genomics:GTL Report from the May 2008 Workshop, DOE/SC-0113, Grequrick, S; Fredrickson, J.K.; Stevens, R., Pub March 1, 2009.)

  11. Genomic Data and Annotation from the SEED

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Fonstein, Michael; Kogan, Yakov; Osterman, Andrei; Overbeek, Ross; Vonstein, Veronika The Fellowship for Interpretation of Genomes (FIG)

    The SEED Project has been extended to support metagenomic samples and concomitant analytical tools. Moreover, the number of genomes being introduced into SEED is growing very rapidly. Building a framework to support this growth while providing highly accurate annotations is centrally important to SEED. The projectĺs subsystem-based annotation strategy has become the technological foundation for addressing these challenges.(copied from Appendix 7 of Systems Biology Knowledgebase for a New Era in Biology, A Genomics:GTL Report from the May 2008 Workshop, DOE/SC-0113, Grequrick, S; Fredrickson, J.K.; Stevens, R., Pub March 1, 2009.)

  12. Genome-Facilitated Analyses of Geomicrobial Processes

    SciTech Connect (OSTI)

    Kenneth H. Nealson

    2012-05-02

    This project had the goal(s) of understanding the mechanism(s) of extracellular electron transport (EET) in the microbe Shewanella oneidensis MR-1, and a number of other strains and species in the genus Shewanella. The major accomplishments included sequencing, annotation, and analysis of more than 20 Shewanella genomes. The comparative genomics enabled the beginning of a systems biology approach to this genus. Another major contribution involved the study of gene regulation, primarily in the model organism, MR-1. As part of this work, we took advantage of special facilities at the DOE: e.g., the synchrotron radiation facility at ANL, where we successfully used this system for elemental characterization of single cells in different metabolic states (1). We began work with purified enzymes, and identification of partially purified enzymes, leading to initial characterization of several of the 42 c-type cytochromes from MR-1 (2). As the genome became annotated, we began experiments on transcriptome analysis under different conditions of growth, the first step towards systems biology (3,4). Conductive appendages of Shewanella, called bacterial nanowires were identified and characterized during this work (5, 11, 20,21). For the first time, it was possible to measure the electron transfer rate between single cells and a solid substrate (20), a rate that has been confirmed by several other laboratories. We also showed that MR-1 cells preferentially attach to cells at a given charge, and are not attracted, or even repelled by other charges. The interaction with the charged surfaces begins with a stimulation of motility (called electrokinesis), and eventually leads to attachment and growth. One of the things that genomics allows is the comparative analysis of the various Shewanella strains, which led to several important insights. First, while the genomes predicted that none of the strains looked like they should be able to degrade N-acetyl glucosamine (NAG), the monomer that makes up chitin, virtually all of the strains were in fact capable. This led to the discovery of a great many new genes involved with chitin and NAG metabolism (7). In a similar vein, a detailed study of the sugar utilization pathway revealed a major new insight into the regulation of sugar metabolism in this genus (19). Systems Biology and Comparative Genomics of the shewanellae: Several publications were put together describing the use of comparative genomics for analyses of the group Shewanella, and these were a logical culmination of our genomic-driven research (10,15,18). Eight graduate students received their Ph.D. degrees doing part of the work described here, and four postdoctoral fellows were supported. In addition, approximately 20 undergraduates took part in projects during the grant period.

  13. Welcome to The Office of Science

    ScienceCinema (OSTI)

    Brinkman, William

    2013-05-29

    The Director of the Department of Energy's Office of Science, Dr. William Brinkman, introduces the new Office of Science website.

  14. Sandia National Labs: PCNSC: Departments: Energy Sciences

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Semiconductor & Optical Sciences Energy Sciences > CINT User Program > CINT Science Small Science Cluster Business Office News Partnering Research Neal Shinn Neal D. Shinn Sr. Manager Lupita Serna Lupita Serna Admin. Asst. Resources P. J. Feibelman Departments Energy Sciences The Energy Sciences Department oversees the operations of the following departments providing oversight in the areas of: Basic Energy Sciences/Materials Science Center for Integrated Nanotechnology (CINT), a

  15. Science Education Programs | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Programs Science Education Student Programs Undergraduates Community College Internship (CCI) National Undergraduate Fellowship Program (NUF) Science Undergraduate Laboratory...

  16. DOE - NNSA/NFO -- Science Bowl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bowl NNSA/NFO Language Options U.S. DOE/NNSA - Nevada Field Office REGISTER NOW FOR THE 2016 NEVADA SCIENCE BOWL HIGH SCHOOL MIDDLE SCHOOL Click Here Click Here Nevada Science Bowl VIDEO: 2015 Nevada Science Bowl Finals The U.S. Department of Energy (DOE) Office of Science sponsors a range of science education initiatives through its Workforce Development for Teachers and Scientists program. Included within this program is the Science Bowl, a nationwide academic science competition. Science Bowl

  17. Sandia National Laboratories: Research: Materials Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Materials Science employees and computer research Sandia excels in innovative fundamental materials science research - developing and integrating the theoretical insights,...

  18. Computing and Computational Sciences Directorate - Contacts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Home ÔÇ║ About Us Contacts Jeff Nichols Associate Laboratory Director Computing and Computational Sciences Becky Verastegui Directorate Operations Manager Computing and Computational Sciences Directorate Michael Bartell Chief Information Officer Information Technologies Services Division Jim Hack Director, Climate Science Institute National Center for Computational Sciences Shaun Gleason Division Director Computational Sciences and Engineering Barney Maccabe Division Director Computer Science

  19. ARM - 1994 ARM Science Team Meeting

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 ARM Science Team Meeting 1994 Meeting 1994 Meeting Home Proceedings Sorted by Author Proceedings Sorted by Title Meeting Archives ARM Science Team Meeting Proceedings Past Science Team Meetings 1994 ARM Science Team Meeting February 28 - March 3 | Charleston, South Carolina The fourth ARM Science Team Meeting was held in Charleston, South Carolina. The Science

  20. Introduction to Using NERSC for the Joint Genome Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NERSC Introduction to Using NERSC for the Joint Genome Institute May 2, 2011 jgi logo sm NERSC Training Event 1:00-5:00 p.m. PDT May 2, 2011 Joint Genome Institute, 2800 Mitchell...