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Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
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1

Cellular and molecular immunotherapeutics derived from the bone marrow stroma  

E-Print Network (OSTI)

The bone marrow contains a multipotent stromal cell, commonly referred to as a mesenchymal stem cell (MSC). There has been recent interest in the clinical use of MSCs for cell-based therapy because: (1) bone marrow aspiration ...

Parekkadan, Biju

2008-01-01T23:59:59.000Z

2

Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation  

E-Print Network (OSTI)

Adipose tissue-derived stem cells (ASCs) are considered as an attractive stem cell source for tissue engineering and regenerative medicine. We compared human bone marrow-derived mesenchymal stem cells (hMSCs) and hASCs ...

Park, Sang-Hyug

3

Lead effects on development and function of bone marrow-derived dendritic cells promote Th2 immune responses  

SciTech Connect

Although lead (Pb) has significant effects on the development and function of macrophages, B cells, and T cells and has been suggested to promote allergic asthma in mice and humans, Pb modulation of bone marrow (BM)-derived dendritic cells (DCs) and the resultant DC effects on Th1 and Th2 development have not been examined. Accordingly, we cultured BM cells with murine granulocyte macrophage-colony stimulating factor (mGM-CSF) {+-} PbCl{sub 2}. At day 10, culture supernatant (SN) and non-adherent cells were harvested for analysis. Additionally, day 10 non-adherent BM-DCs were harvested and recultured with mGM-CSF + LPS {+-} Pb for 2 days. The day 10 Pb exposure significantly inhibited BM-DC generation, based on CD11c expression. Although fewer DCs were generated with Pb, the existing Pb-exposed DCs had significantly greater MHC-II expression than did the non-Pb-exposed DCs. However, these differences diminished upon LPS stimulation. After LPS stimulation, CD80, CD86, CD40, CD54, and MHC-II were all up-regulated on both Pb-DCs and DCs, but Pb-DCs expressed significantly less CD80 than did DCs. The CD86:CD80 ratio suggests a Pb-DC potential for Th2 cell development. After LPS stimulation, IL-6, IL-10, IL-12 (p70), and TNF-{alpha} levels significantly increased with both Pb-DCs and DCs, but Pb-DCs produced significantly less cytokines than did DCs, except for IL-10, which further supports Pb-DC preferential skewing toward type-2 immunity. In vitro studies confirm that Pb-DCs have the ability to polarize antigen-specific T cells to Th2 cells. Pb-DCs also enhanced allogeneic and autologous T cell proliferation in vitro, and in vivo studies suggested that Pb-DCs inhibited Th1 effects on humoral and cell-mediated immunity. The Pb effect was mainly on DCs, rather than on T cells, and Pb's modification of DC function appears to be the main cause of Pb's promotion of type-2-related immunity, which may relate to Pb's enhanced activation of the Erk/MAP kinase pathway.

Gao Donghong [Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509 (United States); Mondal, Tapan K. [Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509 (United States); Lawrence, David A. [Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509 (United States)]. E-mail: lawrencd@wadsworth.org

2007-07-01T23:59:59.000Z

4

Effects of 810-nm Laser on Murine Bone-Marrow-Derived Dendritic Cells  

E-Print Network (OSTI)

Objective: The purpose of this study was to Investigate the effect of 810-nm low level laser therapy (LLLT) on dendritic cells (DC) in vitro. Background data: LLLT can enhance wound healing and increase cell proliferation ...

Chen, Aaron Chih-Hao

5

No evidence for in vivo induction of genomic instability in bone marrow cells collected from mice exposed to low-dose 137Cs γ rays:  

NLE Websites -- All DOE Office Websites (Extended Search)

Rithidech et al, 2006 1 Rithidech et al, 2006 1 No evidence for in vivo induction of genomic instability in bone marrow cells collected from mice exposed to low-dose 137 Cs γ rays: Kanokporn Noy Rithidech 1 , Chatchanok Loetchutinat 1 , Louise Honikel 1 , and Elbert B. Whorton 2 1 Pathology Department, Stony Brook University, Stony Brook, NY 11794-8691 2 Molecular Epidemiology Research Program, University of Texas Medical Branch at Galveston, TX 77555-1153 Assessment of potential health risks associated with exposure to low-dose radiation (at doses below or equal to 0.1 Gy) is still a challenging public health issue. It is therefore important to improve our understanding of potential induction of genomic instability in vivo by this low-dose range because it has been widely suggested that elevation of genomic instability also elevates cancer

6

Proteomic Study of Oral Cancer Stem-Like Cells and Bone Marrow Cell Treatment for Sjgren's Syndrome  

E-Print Network (OSTI)

Carcinoma. Clinical Cancer Research, 2008. 14(13): p. 4085-Cell Lung Cancer. Cancer Research, 2008. 68(15): p. 6065-Inducible Factor-1?. Cancer Research, 2006. 66(7): p. 3688-

Misuno, Kaori

2013-01-01T23:59:59.000Z

7

Dynamic T{sub 2}-mapping during magnetic resonance guided high intensity focused ultrasound ablation of bone marrow  

Science Conference Proceedings (OSTI)

Focal bone tumor treatments include amputation, limb-sparing surgical excision with bone reconstruction, and high-dose external-beam radiation therapy. Magnetic resonance guided high intensity focused ultrasound (MR-HIFU) is an effective non-invasive thermotherapy for palliative management of bone metastases pain. MR thermometry (MRT) measures the proton resonance frequency shift (PRFS) of water molecules and produces accurate (<1 Degree-Sign C) and dynamic (<5s) thermal maps in soft tissues. PRFS-MRT is ineffective in fatty tissues such as yellow bone marrow and, since accurate temperature measurements are required in the bone to ensure adequate thermal dose, MR-HIFU is not indicated for primary bone tumor treatments. Magnetic relaxation times are sensitive to lipid temperature and we hypothesize that bone marrow temperature can be determined accurately by measuring changes in T{sub 2}, since T{sub 2} increases linearly in fat during heating. T{sub 2}-mapping using dual echo times during a dynamic turbo spin-echo pulse sequence enabled rapid measurement of T{sub 2}. Calibration of T{sub 2}-based thermal maps involved heating the marrow in a bovine femur and simultaneously measuring T{sub 2} and temperature with a thermocouple. A positive T{sub 2} temperature dependence in bone marrow of 20 ms/ Degree-Sign C was observed. Dynamic T{sub 2}-mapping should enable accurate temperature monitoring during MR-HIFU treatment of bone marrow and shows promise for improving the safety and reducing the invasiveness of pediatric bone tumor treatments.

Waspe, Adam C.; Looi, Thomas; Mougenot, Charles; Amaral, Joao; Temple, Michael; Sivaloganathan, Siv; Drake, James M. [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, ON, M5G 1X8 (Canada); Philips Healthcare Canada, Markham, ON, L6C 2S3 (Canada); Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, ON, M5G 1X8 (Canada); Department of Applied Mathematics, University of Waterloo, Waterloo, ON, N2L 3G1 (Canada); Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, ON, M5G 1X8 (Canada)

2012-11-28T23:59:59.000Z

8

PROLONGED STUDIES OF CHANGES OF THE COMPOSITION OF THE PERIPHERAL BLOOD AND BONE MARROW IN ANIMALS FOLLOWING WHOLE-BODY SINGLE X IRRADIATION  

SciTech Connect

The changes in the composition of the peripheral blood and the bone marrow in cats following a single whole-body dose of 300 r x radiation were studied over a period of 715 days. The data are tabulated. (J.S.R.)

Tkacheva, T.V.

1959-03-01T23:59:59.000Z

9

Dose Escalation of Total Marrow Irradiation With Concurrent Chemotherapy in Patients With Advanced Acute Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation  

SciTech Connect

Purpose: We have demonstrated that toxicities are acceptable with total marrow irradiation (TMI) at 16 Gy without chemotherapy or TMI at 12 Gy and the reduced intensity regimen of fludarabine/melphalan in patients undergoing hematopoietic cell transplantation (HCT). This article reports results of a study of TMI combined with higher intensity chemotherapy regimens in 2 phase I trials in patients with advanced acute myelogenous leukemia or acute lymphoblastic leukemia (AML/ALL) who would do poorly on standard intent-to-cure HCT regimens. Methods and Materials: Trial 1 consisted of TMI on Days -10 to -6, etoposide (VP16) on Day -5 (60 mg/kg), and cyclophosphamide (CY) on Day -3 (100 mg/kg). TMI dose was 12 (n=3 patients), 13.5 (n=3 patients), and 15 (n=6 patients) Gy at 1.5 Gy twice daily. Trial 2 consisted of busulfan (BU) on Days -12 to -8 (800 {mu}M min), TMI on Days -8 to -4, and VP16 on Day -3 (30 mg/kg). TMI dose was 12 (n=18) and 13.5 (n=2) Gy at 1.5 Gy twice daily. Results: Trial 1 had 12 patients with a median age of 33 years. Six patients had induction failures (IF), and 6 had first relapses (1RL), 9 with leukemia blast involvement of bone marrow ranging from 10%-98%, 5 with circulating blasts (24%-85%), and 2 with chloromas. No dose-limiting toxicities were observed. Eleven patients achieved complete remission at Day 30. With a median follow-up of 14.75 months, 5 patients remained in complete remission from 13.5-37.7 months. Trial 2 had 20 patients with a median age of 41 years. Thirteen patients had IF, and 5 had 1RL, 2 in second relapse, 19 with marrow blasts (3%-100%) and 13 with peripheral blasts (6%-63%). Grade 4 dose-limiting toxicities were seen at 13.5 Gy (stomatitis and hepatotoxicity). Stomatitis was the most frequent toxicity in both trials. Conclusions: TMI dose escalation to 15 Gy is possible when combined with CY/VP16 and is associated with acceptable toxicities and encouraging outcomes. TMI dose escalation is not possible with BU/VP16 due to dose-limiting toxicities. Future efforts will focus on whether further dose escalation with CY/VP16 is safe, with the goal of improving disease control in this high-risk population.

Wong, Jeffrey Y.C., E-mail: jwong@coh.org [Department of Radiation Oncology, City of Hope National Medical Center, Duarte, California (United States); Forman, Stephen; Somlo, George [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States)] [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States); Rosenthal, Joseph [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States) [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States); Department of Pediatrics, City of Hope National Medical Center, Duarte, California (United States); Liu An; Schultheiss, Timothy; Radany, Eric [Department of Radiation Oncology, City of Hope National Medical Center, Duarte, California (United States)] [Department of Radiation Oncology, City of Hope National Medical Center, Duarte, California (United States); Palmer, Joycelynne [Department of Biostatistics, City of Hope National Medical Center, Duarte, California (United States)] [Department of Biostatistics, City of Hope National Medical Center, Duarte, California (United States); Stein, Anthony [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States)] [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States)

2013-01-01T23:59:59.000Z

10

IN VITRO AND IN VIVO ASSESSMENT OF THE VIABILITY OF DOG MARROW AFTER STORAGE  

SciTech Connect

Assessment was made of the abitity of dog marrow cells to survive sterrge at 4 deg C and at --79 deg C. Survival has been assessed in vitro by measurements of rates of DNA synthesis and in vivo by ability to restore marrow functions in lethally irradiated recipients. Dog bone marrow cells synthesize DNA in vitro at values 30 to 80% of normal after storrge for 24 hours at 4 deg C. DNA synthesis is reduced to very low levels by storage for 96 hours at 4 deg C. Eight lethally irradiated bergle dogs (600 to 1500 r) survived acute irradiation effects and returned to normal health after receiving intravenous infusions of autologous bone marrow that had been stored at 4 deg C for 24 hours or less. One dog, similarly irradiatsd, failed to survive when given marrow stored for 96 hours at 4 deg C. A tenth dog did survive when given an exceptionally large quantity of marrow stored for 96 hours at 4 deg C. Dog marrow cells synthesize DNA in vitro at values 40 to 50% of normal in samples stored at --79 deg C in 15% glycerol for periods up to 17 days. Five lethally irradiatsd beagle dogs (1000 to 1500 r) survived acuts irradiation effects and returned to normal health after receiving intravenous infusions of autologous marrow that had been stored at --79 deg C in 15% glycerol. One other dog, similarly irradiated and treated, regained marrow function but died of hepatitis. Two other irradiated dogs similarly treated did not regain marrow function and died. These two had received exceptionally small infusions of marrow cells. The observations demonstrate that dog marrow can be preserved satisfactorily at 4 deg C for 24 hours and in glycerol at --79 deg C for longer periods. The capacity of the stored marrow to synthesize DNA in vitro has correlated well with its ability to induce recovery in lethally irradiated autologous recipients. DNA synthesis in vitro appears to be a useful index of the ability of marrow cells to proliferate in vivo. (auth)

Mannick, J.A.; Lochte, H.L. Jr.; Thomas, E.D.; Ferrebee, J.W.

1960-04-01T23:59:59.000Z

11

ZASC1 knockout mice exhibit an early bone marrow-specific defect in murine leukemia virus replication  

E-Print Network (OSTI)

2005, 12. Okimoto MA, Fan H: Identification of directly2):455463. 16. Belli B, Fan H: The leukemogenic potential19. Lander JK, Chesebro B, Fan H: Appearance of mink cell

2013-01-01T23:59:59.000Z

12

Quantitative correlations among human mesenchymal stem cell mechanical properties and biological function  

E-Print Network (OSTI)

Mesenchymal stem cells (MSCs) are derived from bone marrow, and are capable of proliferating and differentiating along multiple pathways such as osteoblasts, chondrocytes and adipocytes. MSCs offer the means for regenerative ...

Jolibois-Quinot, Remi

2013-01-01T23:59:59.000Z

13

Modified total body irradiation as a planned second high-dose therapy with stem cell infusion for patients with bone-based malignancies  

SciTech Connect

Purpose: To estimate the maximum tolerated dose of hyperfractionated total marrow irradiation (TMI) as a second consolidation after high-dose chemotherapy with autologous or syngeneic blood stem cell transfusion for patients with bone/bone marrow-based malignant disease. Patients and Methods: Fifty-seven patients aged 3-65 years (median, 45 years), including 21 with multiple myeloma, 24 with breast cancer, 10 with sarcoma, and 2 with lymphoma, were treated with 1.5 Gy administered twice daily to a total dose of 12 Gy (n = 27), 13.5 Gy (n = 12), and 15 Gy (n = 18). Median time between the 2 transplants was 105 days (range, 63-162 days). Results: All patients engrafted neutrophils (median, Day 11; range, Day 9-23) and became platelet independent (median, Day 9; range, Day 7-36). There were 5 cases of Grade 3-4 regimen-related pulmonary toxicity, 1 at 12 Gy, and 4 at 15 Gy. Complete responses, partial responses, and stabilizations were achieved in 33%, 26%, and 41% of patients, respectively. Kaplan-Meier estimates of 5-year progression-free survival and overall survival for 56 evaluable patients are 24% and 36%, respectively. Median time of follow-up among survivors was 96 months (range, 77-136 months). Conclusion: Total marrow irradiation as a second myeloablative therapy is feasible. The estimated maximum tolerated dose for TMI in a tandem transplant setting was 13.5 Gy. Because 20% of patients are surviving at 8 years free of disease, further studies of TMI are warranted.

Zaucha, Renata E. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Buckner, Dean C. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Barnett, Todd [The Swedish Hospital Medical Center, Cancer Institute, Seattle, WA (United States); Holmberg, Leona A. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Gooley, Ted [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Hooper, Heather A. P.A.-C. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Maloney, David G. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Appelbaum, Frederick [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Bensinger, William I. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States)]. E-mail: wbensing@fhcrc.org

2006-01-01T23:59:59.000Z

14

Sustained delivery of bioactive TGF-?1 from self-assembling peptide hydrogels induces chondrogenesis of encapsulated bone marrow stromal cells  

E-Print Network (OSTI)

Tissue engineering strategies for cartilage defect repair require technology for local targeted delivery of chondrogenic and anti-inflammatory factors. The objective of this study was to determine the release kinetics of ...

Kopesky, Paul Wayne

15

Organosilicate nanoparticles as gene delivery vehicles for bone cells  

E-Print Network (OSTI)

(cont.) proliferation. The metabolic response of these cells after particle ingestion was also characterized in order to ensure that the osteoblasts retained their phenotype. The expression of various proteins involved in ...

Moudgil, Suniti, 1976-

2004-01-01T23:59:59.000Z

16

2010 Maryland Stem Cell Research Symposium  

Science Conference Proceedings (OSTI)

... and Graft vs. Host Disease (GVHD) in Bone Marrow Transplant Patients. Randal Mills, OSIRIS: Mark Vesely, UMB: Intravenous ...

2010-12-08T23:59:59.000Z

17

Molecular substrate design for the selective adhesion, proliferation and differentiation of marrow connective tissue progenitors  

E-Print Network (OSTI)

A multi-faceted approach was applied to the molecular design of substrates for the selective adhesion, proliferation and differentiation of connective tissue progenitors (CTPs) from human bone marrow aspirates. The basic ...

Au, Ada

2005-01-01T23:59:59.000Z

18

Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells  

Science Conference Proceedings (OSTI)

Mesenchymal stem cells (MSC) from mouse bone marrow were shown to adopt a pancreatic endocrine phenotype in vitro and to reverse diabetes in an animal model. MSC from human bone marrow and adipose tissue represent very similar cell populations with comparable phenotypes. Adipose tissue is abundant and easily accessible and could thus also harbor cells with the potential to differentiate in insulin producing cells. We isolated human adipose tissue-derived MSC from four healthy donors. During the proliferation period, the cells expressed the stem cell markers nestin, ABCG2, SCF, Thy-1 as well as the pancreatic endocrine transcription factor Isl-1. The cells were induced to differentiate into a pancreatic endocrine phenotype by defined culture conditions within 3 days. Using quantitative PCR a down-regulation of ABCG2 and up-regulation of pancreatic developmental transcription factors Isl-1, Ipf-1, and Ngn3 were observed together with induction of the islet hormones insulin, glucagon, and somatostatin.

Timper, Katharina [Department of Research, University Hospital, Basel (Switzerland); Seboek, Dalma [Department of Research, University Hospital, Basel (Switzerland); Eberhardt, Michael [Department of Research, University Hospital, Basel (Switzerland); Linscheid, Philippe [Department of Research, University Hospital, Basel (Switzerland); Christ-Crain, Mirjam [Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Keller, Ulrich [Department of Research, University Hospital, Basel (Switzerland); Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Mueller, Beat [Department of Research, University Hospital, Basel (Switzerland); Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Zulewski, Henryk [Department of Research, University Hospital, Basel (Switzerland) and Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland)]. E-mail: henryk.zulewski@unibas.ch

2006-03-24T23:59:59.000Z

19

Prion Protein is Expressed on Long-term Repopulating Hematopoietic Stem Cells and is Necessary for their Self-renewal  

E-Print Network (OSTI)

We show that the prion protein (PrP) is expressed on the surface of bone marrow cell populations enriched in long-term repopulating hematopoietic stem cells. Affinity purification of the PrP-positive and PrP-negative ...

Lodish, Harvey F.

20

Premeiotic germ cell defect in seminiferous tubules of Atm-null testis  

SciTech Connect

Lifelong spermatogenesis is maintained by coordinated sequential processes including self-renewal of stem cells, proliferation of spermatogonial cells, meiotic division, and spermiogenesis. It has been shown that ataxia telangiectasia-mutated (ATM) is required for meiotic division of the seminiferous tubules. Here, we show that, in addition to its role in meiosis, ATM has a pivotal role in premeiotic germ cell maintenance. ATM is activated in premeiotic spermatogonial cells and the Atm-null testis shows progressive degeneration. In Atm-null testicular cells, differing from bone marrow cells of Atm-null mice, reactive oxygen species-mediated p16{sup Ink4a} activation does not occur in Atm-null premeiotic germ cells, which suggests the involvement of different signaling pathways from bone marrow defects. Although Atm-null bone marrow undergoes p16{sup Ink4a}-mediated cellular senescence program, Atm-null premeiotic germ cells exhibited cell cycle arrest and apoptotic elimination of premeiotic germ cells, which is different from p16{sup Ink4a}-mediated senescence.

Takubo, Keiyo [Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 (Japan)]. E-mail: keiyot@gmail.com; Hirao, Atsushi [Division of Molecular Genetics, Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-0934 (Japan); Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012 (Japan); Ohmura, Masako [Division of Molecular Genetics, Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-0934 (Japan); Azuma, Masaki [Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 (Japan); Department of Urology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Tokyo 113-8655 (Japan); Arai, Fumio [Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 (Japan); Nagamatsu, Go [Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 (Japan); Suda, Toshio [Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 (Japan)]. E-mail: sudato@sc.itc.keio.ac.jp

2006-12-29T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Benzo(a)pyrene and 7,12-dimethylbenz(a)anthrecene differentially affect bone marrow cells of the lymphoid and myeloid lineages  

E-Print Network (OSTI)

lineages. Nature 404, 193­197. Allan, L.L., Mann, K.K., Matulka, R.A., Ryu, H.Y., Schlezinger, J.J., Sherr

Jefcoate, Colin R.

22

In vitro and in vivo growth factor delivery to chondrocytes and bone-marrow-derived stromal cells in cartilage and in self-assembling peptide scaffolds  

E-Print Network (OSTI)

The inability of articular cartilage to repair itself after acute injury has been implicated in the development of osteoarthritis. The objective of this work was to develop methods for delivering growth factors to cartilage ...

Miller, Rachel E. (Rachel Elizabeth)

2010-01-01T23:59:59.000Z

23

The prognostic significance of tumor cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients  

E-Print Network (OSTI)

American Association of Cancer Research Annual Meeting 2008cancer patients. Breast Cancer Research 2011 13:R61. SubmitMolloy et al. Breast Cancer Research 2011, 13:R61 http://

2011-01-01T23:59:59.000Z

24

Effects of bone marrow cell transplant on thyroid function in an I131-induced low T4 and elevated TSH rat model  

E-Print Network (OSTI)

This is an Open Access article distributed under the terms of the Creative Commons Attribution License

Biomed Central; Gustavo E Guajardo-salinas; Juan A Carvajal; ngel A Gaytan-ramos; Luis Arroyo; Alberto G Lpez-reyes; Jos F Islas; Beiman G Cano; Netzahualcoytl Arroyo-currs; Alfredo Dvalos; Gloria Madrid; Jorge E Moreno-cuevas

2007-01-01T23:59:59.000Z

25

Inflammation and Proliferation Act Together to Mediate Intestinal Cell Fusion  

E-Print Network (OSTI)

Cell fusion between circulating bone marrow-derived cells (BMDCs) and non-hematopoietic cells is well documented in various tissues and has recently been suggested to occur in response to injury. Here we illustrate that inflammation within the intestine enhanced the level of BMDC fusion with intestinal progenitors. To identify important microenvironmental factors mediating intestinal epithelial cell fusion, we performed bone marrow transplantation into mouse models of inflammation and stimulated epithelial proliferation. Interestingly, in a non-injury model or in instances where inflammation was suppressed, an appreciable baseline level of fusion persisted. This suggests that additional mediators of cell fusion exist. A rigorous temporal analysis of early post-transplantation cellular dynamics revealed that GFP-expressing donor cells first trafficked to the intestine coincident with a striking increase in epithelial proliferation, advocating for a required fusogenic state of the host partner. Directly supporting this hypothesis, induction of augmented epithelial proliferation resulted in a significant increase in intestinal cell fusion. Here we report that intestinal inflammation and epithelial proliferation act together to promote cell fusion. While the physiologic impact of cell fusion is not yet known, the increased incidence in an inflammatory and proliferative microenvironment suggests a potential role for cell fusion in mediating the progression of

Paige S. Davies; Anne E. Powell; John R. Swain; Melissa H. Wong

2009-01-01T23:59:59.000Z

26

Revised estimates of electron absorbed fractions and radionuclide S-values in trabecular bone  

E-Print Network (OSTI)

The field of nuclear medicine has reached advanced stages in the use of radiopharmaceuticals for the treatment and diagnosis of innumerable maladies. However, along with the use of nuclear medicine come responsibilities inherently associated with the use of radioactive material. It is necessary to be able to calculate doses in the trabecular bone region accurately and consistently. The accurate assessment of patient dose will allow physicians to better predict the amounts of radioactivity needed for specific diagnostic and therapeutic applications. Additionally, improved calculational techniques for bone dosimetry will decrease the likelihood of overadministrations and will allow for reliable predictions of side-effects to patients. The dosimetry of this region is therefore a very important, and unfortunately complicated, area associated with the field of nuclear medicine. A new dosimetric trabecular bone model has been developed and incorporated into a Monte Carlo radiation transport code to determine electron absorbed fractions in red bone marrow and the endosteal tissue which is contained in trabecular bone. The model is based on measured omnidirectional chord length distributions through trabeculae and marrow cavities in nine skeletal locations. Absorbed fractions were calculated for the two target regions, and then estimated from these results for all other skeletal regions thought to contain red marrow. These absorbed fractions were then used to calculate S-values for a variety of beta-emitting radionuclides at each of 15 skeletal locations thought to contain red bone marrow. Absorbed fractions and S-values were calculated for sources in the marrow, on the bone surface, and in the bone volume. Comparisons were made between the new absorbed fractions and those published in ICRP Publication 30, as well as between the new S-values and those determined from the MIRDOSE2 software.

Parry, Robert Alan

1995-01-01T23:59:59.000Z

27

marrow undergoes structural and functional changes, which lead to decreased number of osteoblasts, increased number  

E-Print Network (OSTI)

predisposi- tions, molecular controls and a common cell progenitor. The peroxisome proliferator-activated acid metabolism is largely unknown. Marrow adipocyte differentiation is controlled by the same mecha and represent hallmarks of endocrine activity of extramedullar fat depots from which they are released

Toledo, University of

28

Effects of Electromagnetic Stimulation on Cell Density and Neural Markers in Murine Enteric Cell Cultures  

SciTech Connect

Availability of adult stem cells from several organs like bone marrow, umbilical cord blood or peripheral blood has become a powerful therapeutic tool for many chronic diseases. Potential of adult stem cells for regeneration extents to other tissues among them the nervous system. However two obstacles should be resolved before such cells could be currently applied in clinical practice: a) slow growth rate and b) ability to form enough dense colonies in order to populate a specific injury or cellular deficiency. Many approaches have been explored as genetic differentiation programs, growth factors, and supplemented culture media, among others. Electromagnetic field stimulation of differentiation, proliferation, migration, and particularly on neurogenesis is little known. Since the biological effects of ELF-EMF are well documented, we hypothesize ELF-EMF could affect growth and maturation of stem cells derived of enteric tissue.

Carreon-Rodriguez, A.; Belkind-Gerson, J. [Centro de Investigacion sobre Salud Poblacional, Instituto Nacional de Salud Publica (Mexico); Serrano-Luna, G. [Seccion de Bioelectronica, Departamento de Ingenieria Electrica, CINVESTAV-IPN (Mexico); Canedo-Dorantes, L. [Facultad de Medicina, Universidad Autonoma del Estado de Morelos (Mexico)

2008-08-11T23:59:59.000Z

29

FGF-23 in bone biology  

E-Print Network (OSTI)

6 REVIEW FGF-23 in bone biology Katherine Wesseling-Perryin impairments in bone biology. Although the defectiveof the protein on bone biology, a growing compendium of data

Wesseling-Perry, Katherine

2010-01-01T23:59:59.000Z

30

Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells  

SciTech Connect

Mesenchymal stem cells (MSC) transplantation has been proved to be promising strategy to treat the failing heart. The effect of MSC transplantation is thought to be mediated mainly in a paracrine manner. Recent reports have suggested that cardiac progenitor cells (CPC) reside in the heart. In this study, we investigated whether MSC had paracrine effects on CPC in vitro. CPC were isolated from the neonatal rat heart using an explant method. MSC were isolated from the adult rat bone marrow. MSC-derived conditioned medium promoted proliferation of CPC and inhibited apoptosis of CPC induced by hypoxia and serum starvation. Chemotaxis chamber assay demonstrated that MSC-derived conditioned medium enhanced migration of CPC. Furthermore, MSC-derived conditioned medium upregulated expression of cardiomyocyte-related genes in CPC such as {beta}-myosin heavy chain ({beta}-MHC) and atrial natriuretic peptide (ANP). In conclusion, MSC-derived conditioned medium had protective effects on CPC and enhanced their migration and differentiation.

Nakanishi, Chiaki [Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565 (Japan); Division of Cardiovascular Medicine, Kanazawa University, Graduate School of Medicine, Kanazawa (Japan); Yamagishi, Masakazu [Division of Cardiovascular Medicine, Kanazawa University, Graduate School of Medicine, Kanazawa (Japan); Yamahara, Kenichi [Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565 (Japan); Hagino, Ikuo [Department of Cardiovascular Surgery, National Cardiovascular Center, Osaka (Japan); Mori, Hidezo [Department of Cardiac Physiology, National Cardiovascular Center Research Institute, Osaka (Japan); Sawa, Yoshiki [Department of Surgery, Osaka University Graduate School of Medicine, Osaka (Japan); Yagihara, Toshikatsu; Kitamura, Soichiro [Department of Cardiovascular Surgery, National Cardiovascular Center, Osaka (Japan); Nagaya, Noritoshi [Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565 (Japan)], E-mail: myamagi@med.kanazawa-u.ac.jp

2008-09-12T23:59:59.000Z

31

Orthopaedic tissue engineering and bone regeneration  

Science Conference Proceedings (OSTI)

Orthopaedic tissue engineering combines the application of scaffold materials, cells and the release of growth factors. It has been described as the science of persuading the body to reconstitute or repair tissues that have failed to regenerate or heal ... Keywords: Bone, biodegradable polymers, biomaterials, cell therapy, fracture repair, orthopaedics, tissue engineering

Glenn Dickson; Fraser Buchanan; David Marsh; Eileen Harkin-Jones; Uel Little; Mervyn McCaigue

2007-01-01T23:59:59.000Z

32

Alkali-free bioactive glasses for bone tissue engineering: A preliminary investigation  

SciTech Connect

An alkali-free series of bioactive glasses has been designed and developed in the glass system CaO-MgO-SiO2-P2O5-CaF2 along diopside (CaMgSi2O6) fluorapatite [Ca5(PO4)3F] tricalcium phosphate (3CaOP2O5) join. The silicate network in all the investigated glasses is predominantly coordinated in Q2 (Si) units while phosphorus tends to remain in orthophosphate (Q0) environment. The in vitro bioactivity analysis of glasses has been made by immersion of glass powders in simulated body fluid (SBF) while chemical degradation has been studied in Tris-HCl in accordance with ISO-10993-14. Some of the investigated glasses exhibit hydroxyapatite (HA) formation on their surface with in 1-12 h of their immersion in SBF solution. The sintering and crystallization kinetics of glasses has been investigated by differential thermal analysis (DTA) and hot-stage microscopy (HSM), respectively while the crystalline phase evolution in resultant glass-ceramics (GCs) has been studied in the temperature range of 800-900 oC using powder X-ray diffraction (XRD) and scanning electron microscope (SEM). The cell growth and osteogenic differentiation for glasses has been studied in vitro on sintered glass powder compacts using rat bone marrow mesenchymal stem cells. The as designed glasses are ideal candidates for their potential applications in bone tissue engineering in the form of bioactive glasses as well as glass/GC scaffolds.

Goel, Ashutosh; Kapoor, Saurabh; Rajagopal, Raghu R.; Pascual, Maria J.; Kim, Hae-Won; Ferreira, Jose M.

2011-08-25T23:59:59.000Z

33

Comparison between Culture Conditions Improving Growth and ...  

Science Conference Proceedings (OSTI)

Keywords: Blood Cells, Bone Marrow Cells, Cell Proliferation, Cell Survival, Mesenchymal Stem .... Abano Terme, Italy), a non-woven hyaluronan-based scaffold.

34

Non-invasive shock wave stimulated periosteum for bone tissue engineering  

E-Print Network (OSTI)

The cambium cells of the periosteum, which are known osteoprogenitor cells, have limited suitability for clinical applications of bone tissue engineering due to their low cell number (2-5 cells thick). Extracorporeal shock ...

Kearney, Cathal (Cathal John)

2011-01-01T23:59:59.000Z

35

Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment  

Science Conference Proceedings (OSTI)

The aim of this study was to determine whether intravenously administered multipotent stromal cells from human bone marrow (hMSCs) can improve cardiac function after myocardial infarction (MI) without long-term engraftment and therefore whether transitory paracrine effects or secreted factors are responsible for the benefit conferred. hMSCs were injected systemically into immunodeficient mice with acute MI. Cardiac function and fibrosis after MI in the hMSC-treated group were significantly improved compared with controls. However, despite the cardiac improvement, there was no evident hMSC engraftment in the heart 3 weeks after MI. Microarray assays and ELISAs demonstrated that multiple protective factors were expressed and secreted from the hMSCs in culture. Factors secreted by hMSCs prevented cell death of cultured cardiomyocytes and endothelial cells under conditions that mimicked tissue ischemia. The favorable effects of hMSCs appear to reflect the impact of secreted factors rather than engraftment, differentiation, or cell fusion.

Iso, Yoshitaka [Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Cardiovascular Research Institute, Department of Medicine, University of Vermont, 208 South Park Drive, Colchester, VT 05446 (United States); Spees, Jeffrey L. [Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Cardiovascular Research Institute, Department of Medicine, University of Vermont, 208 South Park Drive, Colchester, VT 05446 (United States); E-mail: Jeffrey.Spees@uvm.edu; Serrano, Claudia [Section of Cardiology, Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Bakondi, Benjamin [Cardiovascular Research Institute, Department of Medicine, University of Vermont, 208 South Park Drive, Colchester, VT 05446 (United States); Pochampally, Radhika [Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Song, Yao-Hua [Section of Cardiology, Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Sobel, Burton E. [Cardiovascular Research Institute, Department of Medicine, University of Vermont, 208 South Park Drive, Colchester, VT 05446 (United States); Delafontaine, Patrick [Section of Cardiology, Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Prockop, Darwin J. [Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States)]. E-mail: dprocko@tulane.edu

2007-03-16T23:59:59.000Z

36

Biodegradable synthetic bone composites  

DOE Patents (OSTI)

The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

Liu, Gao; Zhao, Dacheng; Saiz, Eduardo; Tomsia, Antoni P.

2013-01-01T23:59:59.000Z

37

Digital electronic bone growth stimulator  

DOE Patents (OSTI)

A device is described for stimulating bone tissue by applying a low level alternating current signal directly to the patient`s skin. A crystal oscillator, a binary divider chain and digital logic gates are used to generate the desired waveforms that reproduce the natural electrical characteristics found in bone tissue needed for stimulating bone growth and treating osteoporosis. The device, powered by a battery, contains a switch allowing selection of the correct waveform for bone growth stimulation or osteoporosis treatment so that, when attached to the skin of the patient using standard skin contact electrodes, the correct signal is communicated to the underlying bone structures. 5 figs.

Kronberg, J.W.

1995-05-09T23:59:59.000Z

38

Digital electronic bone growth stimulator  

DOE Patents (OSTI)

A device for stimulating bone tissue by applying a low level alternating current signal directly to the patient's skin. A crystal oscillator, a binary divider chain and digital logic gates are used to generate the desired waveforms that reproduce the natural electrical characteristics found in bone tissue needed for stimulating bone growth and treating osteoporosis. The device, powered by a battery, contains a switch allowing selection of the correct waveform for bone growth stimulation or osteoporosis treatment so that, when attached to the skin of the patient using standard skin contact electrodes, the correct signal is communicated to the underlying bone structures.

Kronberg, James W. (Aiken, SC)

1995-01-01T23:59:59.000Z

39

131I-Anti-CD45 Antibody Plus Busulfan and Cyclophosphamide before Allogeneic Hematophoietic Cell Transplantation for Treatment of Acute Myeloid Leukemia in First Remission  

Science Conference Proceedings (OSTI)

In an attempt to improve outcomes for patients with acute myeloid leukemia (AML) after allogeneic hematopoietic cell transplantation (HCT), we conducted a Phase I/II study in which targeted irradiation delivered by 131I-anti-CD45 antibody was combined with targeted busulfan (BU; area-under-curve, 600-900 ng/ml) and cyclophosphamide (CY; 120 mg/kg). Fifty-two of 59 patients (88%) receiving a trace 131I-labeled dose of 0.5 mg/kg anti-CD45 murine antibody had higher estimated absorbed radiation in bone marrow and spleen than in any other organ. Forty-six patients were treated with 102-298 mCi 131I delivering an estimated 5.3-19 (mean 11.3) Gy to marrow, 17-72 (mean 29.7) Gy to spleen, and 3.5 Gy (n=4) to 5.25 Gy (n=42) to the liver. The estimated 3-year non-relapse mortality and disease-free survival (DFS) were 21% and 61%, respectively. These results were compared to those from 509 similar International Bone Marrow Transplant Registry patients transplanted using BU/CY alone. After adjusting for differences in age and cytogenetics-risk, the hazard of mortality among all antibody-treated patients was 0.65 times that of the Registry patients (95% CI 0.39-1.08; p=.09). The addition of targeted hematopoietic irradiation to conventional BU/CY is feasible and well tolerated, and Phase II results are sufficiently encouraging to warrant further study.

Pagel, John M.; Appelbaum, Frederick R.; Eary, Janet F.; Rajendran, Joseph G.; Fisher, Darrell R.; Gooley, Ted; Ruffner, Katherine; Nemecek, Eneida; Sickle, Eileen; Durack, Larry; Carreras, Jeanette; Horowitz, Mary; Press, Oliver W.; Gopal, Ajay K.; Martin, Paul J.; Bernstein, Irwin D.; Matthews, Dana C.

2006-03-01T23:59:59.000Z

40

Hypersensitivity of human and rodent Fanconi anemia (FA) cells to bystander  

NLE Websites -- All DOE Office Websites (Extended Search)

Paul Wilson Paul Wilson Lawrence Livermore National Laboratory Abstract Fanconi anemia (FA) is a chromosomal instability and cancer predisposition syndrome characterized by developmental defects, progressive bone marrow failure, and cellular hypersensitivity to agents that induce DNA interstrand crosslinks and oxidative stress [1]. The disease is transmitted either as an autosomal-recessive or X-linked trait, and mutations in 13 FA genes have been identified in FA patients (with more likely to be discovered). Previously, we reported on the hypersensitivity of the isogenic Fancg-deficient Chinese hamster ovary (CHO) mutant KO40 for sister chromatid exchange (SCE) induction following low dose 3.86-MeV plutonium-238 α-particle irradiation where <1% of cell nuclei are hit.

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

PROLONGED STORAGE OF MARROW AND ITS USE IN THE TREATMENT OF RADIATION INJURY  

SciTech Connect

Marrow was removed from the femurs. f dogs and frozen in 15% glycerol at 1 deg C per minute. Marrow from one dog was stored at -80 deg C and from the other at -180 deg C for a period of 14 months. Each dog was then given 1200 r of wholebody irradiation followed by infusion of his own thawed marrow. Recovery was rapid, and the dogs were living and well two months later. (auth)

Thomas, E.D.; Ferrebee, J.W.

1962-03-01T23:59:59.000Z

42

Verification of dose distribution for volumetric modulated arc therapy total marrow irradiation in a humanlike phantom  

SciTech Connect

Purpose: Volumetric modulated arc therapy (VMAT) treatment planning studies have been reported to provide good target coverage and organs at risk (OARs) sparing in total marrow irradiation (TMI). A comprehensive dosimetric study simulating the clinical situation as close as possible is a norm in radiotherapy before a technique can be used to treat a patient. Without such a study, it would be difficult to make a reliable and safe clinical transition especially with a technique as complicated as VMAT-TMI. To this end, the dosimetric feasibility of VMAT-TMI technique in terms of treatment planning, delivery efficiency, and the most importantly three dimensional dose distribution accuracy was investigated in this study. The VMAT-TMI dose distribution inside a humanlike Rando phantom was measured and compared to the dose calculated using RapidArc especially in the field junctions and the inhomogeneous tissues including the lungs, which is the dose-limiting organ in TMI. Methods: Three subplans with a total of nine arcs were used to treat the planning target volume (PTV), which was determined as all the bones plus the 3 mm margin. Thermoluminescent detectors (TLDs) were placed at 39 positions throughout the phantom. The measured TLD doses were compared to the calculated plan doses. Planar dose for each arc was verified using mapcheck. Results: TLD readings demonstrated accurate dose delivery, with a median dose difference of 0.5% (range: -4.3% and 6.6%) from the calculated dose in the junctions and in the inhomogeneous medium including the lungs. Conclusions: The results from this study suggest that RapidArc VMAT technique is dosimetrically accurate, safe, and efficient in delivering TMI within clinically acceptable time frame.

Surucu, Murat; Yeginer, Mete; Kavak, Gulbin O.; Fan, John; Radosevich, James A.; Aydogan, Bulent [Department of Radiation and Cellular Oncology University of Chicago, 5758 South Maryland Avenue, MC 9006, Chicago, Illinois 60637 (United States); Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, Chicago, Illinois 60612 (United States); Department of Radiation Oncology, Edwards Hospital, 801 South Washington Street, Naperville, Illinois 60540 (United States); Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, Chicago, Illinois 60612 (United States); Department of Radiation and Cellular Oncology University of Chicago, 5758 South Maryland Avenue, MC 9006, Chicago, Illinois 60637 (United States) and Department of Radiation Oncology, University of Illinois at Chicago Medical Center, 1801 West Taylor Street, C400, Chicago, Illinois 60612 (United States)

2012-01-15T23:59:59.000Z

43

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

mesenteric lymph nodes, degeneration of bone marrow cells, and retardation of thyroid gland development. Increased mortality was observed with newborn mice after treatment...

44

Bone Canonical WNT/B-Catenin Signaling in Models of Reduced Microgravity  

E-Print Network (OSTI)

Human exposure to reduced weightbearing results in bone loss. The rate of bone loss during microgravity exposure is similar to that of a post-menopausal women. In fact, the maintenance of bone mass is intimately dependent on exercise. Therefore, exercise associated mechanical loads to bone tissue are an important countermeasure to prevent disuse-induced bone loss. However, the types of exercise modalities required to prevent such bone loss are unclear. Moreover, how mechanical loading to bone translates into molecular osteogenic signals in bone cells is unknown. Radiation exposure is another potent inducer of bone loss, namely observed on Earth in the clinical setting following radiotherapy procedures. It is expected that long duration space missions outside the protection of Earths magnetosphere will result in significant galactic cosmic radiation exposure. However, the magnitude of bone loss resulting from this galactic cosmic radiation exposure is unclear. Moreover, it is unknown if radiation exposure will exacerbate disuse-induced bone loss. Therefore, a series of experiments were designed to determine: 1) Will simulated galactic cosmic radiation exacerbate reduced weightbearing-induced bone loss? 2) Will pharmacological activation of the putative mechanosensing Wnt pathway enhance exercise-induced bone mass gain? To address these questions the experimental study series employed two animal models of reduced weightbearing, hindlimb unloading and partial weightbearing. These model test-beds enabled the evaluation of two novel countermeasures (simulated resistance exercise and glycogen synthase kinase-3 (GSK-3) therapeutic) and simulated exposure to space radiation environments. To test the impact of simulated space radiation (28Si) one study of the series was conducted at Brookhaven National Laboratory. To quantify the impact of the abovementioned countermeasures and space radiation on bone, mechanical testing, peripheral quantitative computed tomography, micro-computed tomography, histomorphometry, and immunohistochemistry served as primary outcome measures. The primary findings are: 1) Low-dose high-LET radiation negativity impacts maintenance of bone mass by lowering bone formation and increasing bone resorption. This impaired bone formation response is in part due to sclerostin induced suppression of Wnt signaling. 2) Combining GSK-3 inhibition with high intensity exercise mitigates cancellous bone loss and restores cortical periosteal growth during disuse.

Macias, Brandon 1979-

2012-12-01T23:59:59.000Z

45

BoneMaster HA Coating An In Vivo Assessment  

Science Conference Proceedings (OSTI)

... group (668 N) demonstrated significantly higher pull out strength than control PPS group (348 N). After 32 weeks, the pull out strength for BoneMaster HA and PPS groups ... Facilitates Neural Stem Cell Adhesion, Proliferation and Differentiation ... Sol-Gel Synthesis of Bio-Active Nanoporous Sodium Zirconate Coated on...

46

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic...

47

Positive modulator of bone morphogenic protein-2  

DOE Patents (OSTI)

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

Zamora, Paul O. (Gaithersburg, MD); Pena, Louis A. (Poquott, NY); Lin, Xinhua (Plainview, NY); Takahashi, Kazuyuki (Germantown, MD)

2009-01-27T23:59:59.000Z

48

6Bone Backbone Routing Guidelines  

Science Conference Proceedings (OSTI)

The 6Bone is an Ipv6 testbed to assist in the evolution and deployment of IPv6. Because of this, it is important that the core backbone of the IPv6 network maintain stability, and that all operators have a common set of rules and guidelines by which ...

R. Rockell; R. Fink

2000-02-01T23:59:59.000Z

49

Digital electronic bone growth stimulator  

DOE Patents (OSTI)

The present invention relates to the electrical treatment of biological tissue. In particular, the present invention discloses a device that produces discrete electrical pulse trains for treating osteoporosis and accelerating bone growth. According to its major aspects and broadly stated, the present invention consists of an electrical circuit configuration capable of generating Bassett-type waveforms shown with alternative signals provide for the treatment of either fractured bones or osteoporosis. The signal generator comprises a quartz clock, an oscillator circuit, a binary divider chain, and a plurality of simple, digital logic gates. Signals are delivered efficiently, with little or no distortion, and uniformly distributed throughout the area of injury. Perferably, power is furnished by widely available and inexpensive radio batteries, needing replacement only once in several days. The present invention can be affixed to a medical cast without a great increase in either weight or bulk. Also, the disclosed stimulator can be used to treat osteoporosis or to strengthen a healing bone after the cast has been removed by attaching the device to the patient`s skin or clothing.

Kronberg, J.W.

1993-01-01T23:59:59.000Z

50

Near-infrared emitting quantum dots for cellular and vascular fluorescent labeling in in vivo multiplexed imaging studies  

E-Print Network (OSTI)

In vivo multimodal, multiplexed microscopy allows real-time observation of hematopoietic cells, their stem and progenitor cells and metastatic cancer cells in their native bone marrow (BM) environment. Multiplexing has ...

Wu, Juwell Wendy

2011-01-01T23:59:59.000Z

51

The Effects of Obesity on Murine Cortical Bone  

E-Print Network (OSTI)

34, 376 (2004). S. S. Ionova-Martin, et al. , Bone 46, 217 (Cortical Bone by Sophi Martin A dissertation submitted inMurine Cortical Bone by Sophi Martin ABSTRACT The Effects of

Martin, Sophi

2010-01-01T23:59:59.000Z

52

Bioactive Glass Scaffolds for Bone Regeneration  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

53

Bioactive Glass Scaffolds for Bone Regeneration  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

54

Bioactive Glass Scaffolds for Bone Regeneration  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioactive Glass Scaffolds for Bioactive Glass Scaffolds for Bone Regeneration Bioactive Glass Scaffolds for Bone Regeneration Print Wednesday, 28 September 2011 00:00 Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

55

Bioactive Glass Scaffolds for Bone Regeneration  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

56

Bioactive Glass Scaffolds for Bone Regeneration  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

57

Effects of glucocorticoid treatment on bone strength  

Science Conference Proceedings (OSTI)

gene results in the autosomal dominant high-bone-mass trait. Am. J Hum Genet 70:1119. 33. Dubrow SA, Hruby PM, Akhter MP (2007) Gender specific LRP5.

58

Microdamage accumulation in bovine trabecular bone  

E-Print Network (OSTI)

When bone is loaded beyond its failure point, it develops damage in the form of microcracks. Normally, microcracks are repaired by the remodeling process, limiting the number of in vivo microcracks. However, if the rate ...

Moore, Tara L. Arthur (Tara Lee Arthur), 1972-

2001-01-01T23:59:59.000Z

59

Fracture, aging and disease in bone  

E-Print Network (OSTI)

and R. O. Ritchie: Effect of aging on the toughness of humanof microstructure in the aging-related deterioration of thestudy of the effect of aging on human cortical bone J.

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

60

Effects of High Dietary Iron and Gamma Radiation on Oxidative Stress and Bone  

E-Print Network (OSTI)

Astronauts in space flight missions are exposed to increased iron (Fe) stores and galactic cosmic radiation, both of which independently induce oxidative stress. Oxidative stress can result in protein, lipid, and DNA oxidation. Recent evidence has linked oxidative stress to bone loss with aging and estrogen deficiency. Whether the increased iron stores and radiation that astronauts face are exacerbating their extreme bone loss while in space is unclear. We hypothesized that elevated iron levels (induced by feeding a high iron diet) and gamma radiation exposure would independently increase markers of oxidative stress and markers of oxidative damage and result in loss of bone mass, with the combined treatment having additive or synergistic effects. Male Sprague-Dawley rats (15-weeks old, n=32) were randomized to receive an adequate (45 mg Fe/kg diet) or high (650 mg Fe/kg diet) Fe diet for 4 weeks and either 3 Gy (8 fractions, 0.375 Gy each) of 137Cs radiation (?RAD) or sham exposure every other day over 16 days starting on day 14. Serum Fe and catalase and liver Fe and glutathione peroxidase (GPX) were assessed by standard techniques. Immunostaining for 8-hydroxy-2-deoxyguanosine (8-OHdG, marker of DNA adducts) quantified the number of cells with oxidative damage in cortical bone. Bone histomorphometry assessed bone cell activity and cancellous bone microarchitecture in the metaphyseal region. Ex vivo pQCT quantified volumetric bone mineral density (vBMD); bone mechanical strength was assessed by 3-pt bending at the midshaft tibia and compression of the femoral neck. High Fe diet increased liver Fe and decreased volume per total volume (BV/TV). ?RAD decreased osteoid surface per bone surface (OS/BS) and osteocyte density. The combined treatment increased serum catalase, liver GPX, and serum iron and decreased cancellous vBMD and trabecular number (Tb.N). High Fe diet and ?RAD independently increased number of osteocytes stained positive for 8-OHdG, with the combined treatment exhibiting twice as many osteocytes positively stained compared to the control. Higher serum Fe levels were associated with higher oxidative damage (r =0.38) and lower proximal tibial cancellous vBMD (r =0.38). Higher serum catalase levels were associated with higher oxidative damage (r =0.48), lower BV/TV (r =0.40) and lower cancellous vBMD (r =0.39). High dietary iron and fractionated 137Cs ?RAD leads to a moderate elevation in iron stores and results in oxidative damage in bone and are associated with decreased cancellous bone density. Moderate elevations in iron stores are not only found in astronauts, but also naturally occur in healthy human populations. This healthy population with elevated iron stores may also have increased levels of oxidative stress in the body. Elevated levels of oxidative stress not only increase ones risk for accelerated bone loss, but also the risk of developing other chronic diseases such as insulin resistance, hypertension, dyslipidemia, and metabolic syndrome.

Yuen, Evelyn P

2013-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

The roll of integrins in hematopoiesis  

E-Print Network (OSTI)

Hematopoietic stem cells (HSCs) hold great promise for the treatment of disease. The rare frequency at which HSCs occur in the bone marrow under homeostatic conditions is a limiting factor in both their study and clinical ...

Eshghi, Shawdee

2007-01-01T23:59:59.000Z

62

Celebrating Black History Month with DOE's Sheri Bone | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

with DOE's Sheri Bone with DOE's Sheri Bone Celebrating Black History Month with DOE's Sheri Bone February 9, 2011 - 2:04pm Addthis Sheri Bone. | File photo. Sheri Bone. | File photo. Ebony Meeks Former Assistant Press Secretary, Office of Public Affairs Throughout the month of February, we're introducing some remarkable African Americans who are working to advance the President's clean energy agenda and help the Department of Energy achieve its mission. This week we're profiling Sheri Bone who is Senior Project Director, Office of Nuclear Materials Integration, National Nuclear Security Administration. Sheri Bone Question: What is your key responsibility? SB: I'm responsible for developing the Department of Energy's strategic plan for nuclear materials. This means directing and leading a team of

63

Functional and phenotypic effects of AhR activation in inflammatory dendritic cells  

SciTech Connect

Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces immune suppression. Dendritic cells (DCs) are key antigen presenting cells governing T cell activation and differentiation. However, the consequences of AhR activation in DCs are not fully defined. We hypothesized that AhR activation alters DC differentiation and generates dysfunctional DCs. To test this hypothesis, inflammatory bone marrow-derived DCs (BMDCs) from C57Bl/6 mice were generated in the presence of vehicle or TCDD. TCDD decreased CD11c expression but increased MHC class II, CD86 and CD25 expression on the BMDCs. The effects of TCDD were strictly AhR-dependent but not exclusively DRE-mediated. Similar effects were observed with two natural AhR ligands, 6-formylindolo[3,2-b]carbazole (FICZ) and 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid (ITE). TCDD increased LPS- and CpG-induced IL-6 and TNF-{alpha} production by BMDCs but decreased their NO production. TCDD decreased CpG-induced IL-12p70 production by BMDCs but did not affect their secretion of IL-10. TCDD downregulated LPS- and CpG-induced NF-kB p65 levels and induced a trend towards upregulation of RelB levels in the BMDCs. AhR activation by TCDD modulated BMDC uptake of both soluble and particulate antigens. Induction of indoleamine-2,3-dioxygenase (IDO) and TGF-{beta}3 has been implicated in the generation of regulatory T cells following AhR activation. TCDD increased IDO1, IDO2 and TGF-{beta}3 mRNA levels in BMDCs as compared to vehicle. Despite the induction of regulatory mediators, TCDD-treated BMDCs failed to suppress antigen-specific T cell activation. Thus, AhR activation can directly alter the differentiation and innate functions of inflammatory DCs without affecting their ability to successfully interact with T cells.

Bankoti, Jaishree [Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT (United States); Center for Environmental Health Sciences, University of Montana, Missoula, MT (United States); Rase, Ben [Center for Environmental Health Sciences, University of Montana, Missoula, MT (United States); Simones, Tom [Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT (United States); Center for Environmental Health Sciences, University of Montana, Missoula, MT (United States); Shepherd, David M., E-mail: david.shepherd@umontana.ed [Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT (United States); Center for Environmental Health Sciences, University of Montana, Missoula, MT (United States)

2010-07-15T23:59:59.000Z

64

On nano size structures for enhanced bone formation.  

E-Print Network (OSTI)

??Purpose The general aim of the present thesis was to investigate early bone response to titanium implants modified with nano size structures. Therefore, 1. a (more)

Meirelles, Luiz

2007-01-01T23:59:59.000Z

65

Bone scanning in the detection of occult fractures  

SciTech Connect

The potential role of bone scanning in the early detection of occult fractures following acute trauma was investigated. Technetium 99m pyrophosphate bone scans were obtained in patients with major clinical findings and negative or equivocal roentgenograms following trauma. Bone scanning facilitated the prompt diagnosis of occult fractures in the hip, knee, wrist, ribs and costochondral junctions, sternum, vertebrae, sacrum, and coccyx. Several illustrative cases are presented. Roentgenographic confirmation occurred following a delay of days to weeks and, in some instances, the roentgenographic findings were subtle and could be easily overlooked. This study demonstrates bone scanning to be invaluable and definitive in the prompt detection of occult fractures.

Batillas, J.; Vasilas, A.; Pizzi, W.F.; Gokcebay, T.

1981-07-01T23:59:59.000Z

66

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

above a micron, toughening mechanisms can be markedly changed. Cortical bones' resistance to fracture in the transverse (breaking) orientation can be associated with...

67

Directed Bone Regeneration to Prevent Fatigue Failure of  

Science Conference Proceedings (OSTI)

... given for OC-Implants used as artifical bone grafts. Results include macro radiographs, CAT scans, and microscpic and SEM evaluation of recovered sections.

68

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

69

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

70

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

71

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Irradiation Effects on Human Cortical Bone Fracture Behavior Irradiation Effects on Human Cortical Bone Fracture Behavior Print Wednesday, 28 July 2010 00:00 Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

72

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

73

Hazards Associated with the Use of Bone Ash in Contact with Molten ...  

Science Conference Proceedings (OSTI)

Bone ash itself is non-toxic and environmentally benign. However recent evidence indicates that bone ash can be reduced upon contact with aluminum alloys to...

74

Genomic deletion of a long-range bone enhancer misregulatessclerostin in Van Buchem disease  

Science Conference Proceedings (OSTI)

Mutations in distant regulatory elements can negatively impact human development and health, yet due to the difficulty of detecting these critical sequences we predominantly focus on coding sequences for diagnostic purposes. We have undertaken a comparative sequence-based approach to characterize a large noncoding region deleted in patients affected by Van Buchem disease (VB), a severe sclerosing bone dysplasia. Using BAC recombination and transgenesis we characterized the expression of human sclerostin (sost) from normal (hSOSTwt) or Van Buchem(hSOSTvb D) alleles. Only the hSOSTwt allele faithfully expressed high levels of human sost in the adult bone and impacted bone metabolism, consistent with the model that the VB noncoding deletion removes a sost specific regulatory element. By exploiting cross-species sequence comparisons with in vitro and in vivo enhancer assays we were able to identify a candidate enhancer element that drives human sost expression in osteoblast-like cell lines in vitro and in the skeletal anlage of the E14.5 mouse embryo, and discovered a novel function for sclerostin during limb development. Our approach represents a framework for characterizing distant regulatory elements associated with abnormal human phenotypes.

Loots, Gabriela G.; Kneissel, Michaela; Keller, Hansjoerg; Baptist, Myma; Chang, Jessie; Collette, Nicole M.; Ovcharenko, Dmitriy; Plajzer-Frick, Ingrid; Rubin, Edward M.

2005-04-15T23:59:59.000Z

75

Differences in Bone Quality between High versus Low Turnover Renal Osteodystrophy  

SciTech Connect

Abnormal bone turnover is common in chronic kidney disease (CKD), but its effects on bone quality remain unclear. This study sought to quantify the relationship between abnormal bone turnover and bone quality. Iliac crest bone biopsies were obtained from CKD-5 patients on dialysis with low (n=18) or high (n=17) turnover, and from volunteers (n=12) with normal turnover and normal kidney function. Histomorphometric methods were used to quantify the microstructural parameters; Fourier transform infrared spectroscopy and nanoindentation were used to quantify the material and mechanical properties in bone. Reduced mineral-to-matrix ratio, mineral crystal size, stiffness and hardness were observed in bone with high turnover compared to bone with normal or low turnover. Decreased cancellous bone volume and trabecular thickness were seen in bone with low turnover compared to bone with normal or high turnover. Bone quality, as defined by its microstructural, material, and mechanical properties, is related to bone turnover. These data suggest that turnover related alterations in bone quality may contribute to the known diminished mechanical competence of bone in CKD patients, albeit from different mechanisms for bone with high (material abnormality) vs. low (microstructural alteration) turnover. The present findings suggest that improved treatments for renal osteodystrophy should seek to avoid low or high bone turnover and aim for turnover rates as close to normal as possible.

Porter, Daniel S. [University of Kentucky, Lexington; Pienkowski, David [University of Kentucky, Lexington; Faugere, Marie-Claude [Albert B. Chandler Medical Center; Malluche, Hartmut H. [Albert B. Chandler Medical Center

2012-01-01T23:59:59.000Z

76

Relation between hydrogen isotopic ratios of bone collagen and rain  

Science Conference Proceedings (OSTI)

The hydrogen isotopic value ([delta]D) of deer bone collagen is related to both [delta]D of rain during the growing season and growing season relative humidity (RH). With correction for the effects of RH, bone [delta]D is related to growing season rain [delta]D in a simple manner with a slope of 1.0. This indicates that, with RH correction, there are no additional sources of bias in the [delta]D of bone due to unaccounted for biologic or climatic effects. Due to a low sensitivity of bone [delta]D to RH effects, both yearly and growing season rain [delta]D can be estimated with considerable accuracy (R = 0.97 and R = 0.96) from bone collagen [delta]D and [delta][sup 15]N. Here, [delta][sup 15]N is used to correct bone [delta]D for the effects of RH. From these estimates of rain [delta]D, it may then be possible to evaluate temperature since the [delta]D of rain primarily reflects local temperature. Therefore, the measurement of bone collagen [delta]D has good potential for evaluating paleoclimates.

Cormie, A.B.; Schwarcz, H.P. (McMaster Univ., Hamilton, Ontario (Canada)); Gray, J. (Univ. of Alberta, Edmonton (Canada))

1994-01-01T23:59:59.000Z

77

Nanoscale Surface Topography to Guide Bone Growth  

Science Conference Proceedings (OSTI)

... As seen in the fluorescence microscopy images, cells align with the gradient at the high end of the taper (left), and orient randomly on the low end ...

2013-01-24T23:59:59.000Z

78

On the mechanistic origins of toughness in bone  

Science Conference Proceedings (OSTI)

One of the most intriguing protein materials found in Nature is bone, a material composed out of assemblies of tropocollagen molecules and tiny hydroxyapatite mineral crystals, forming an extremely tough, yet lightweight, adaptive and multi-functional material. Bone has evolved to provide structural support to organisms, and therefore, its mechanical properties are of great physiological relevance. In this article, we review the structure and properties of bone, focusing on mechanical deformation and fracture behavior from the perspective of the multi-dimensional hierarchical nature of its structure. In fact, bone derives its resistance to fracture with a multitude of deformation and toughening mechanisms at many of these size-scales, ranging from the nanoscale structure of its protein molecules to its macroscopic physiological scale.

Launey, Maximilien E.; Buehler, Markus J.; Ritchie, Robert O.

2009-10-07T23:59:59.000Z

79

Resection followed by vascularized bone autograft in patients with possible recurrence of malignant bone tumors after conservative treatment  

SciTech Connect

In conservative treatment of malignant bone tumors, assessment of the local condition is difficult. The radiological changes seen in the irradiated tumor and the frequent occurrence of pathological fractures at this site may give rise to the fear that the tumor has relapsed. Resection of the whole of the involved bone is the best way to assure adequate local control but the extent of the bone defect and the bad local conditions secondary to irradiation make reconstruction hazardous. In two patients (one with Ewing's sarcoma of the femur and one with osteogenic sarcoma of the humerus) the authors used a free, vascularized fibular graft for the reconstruction having obtained consolidation of the limb after resection of the irradiated tumor, with preservation of its function. The encouraging results obtained have suggested a conservative attitude as primary treatment of specific malignant bone tumors.

Metaizeau, J.P.; Olive, D.; Bey, P.; Bordigoni, P.; Plenat, F.; Prevot, J.

1984-04-01T23:59:59.000Z

80

Triple-phase bone image abnormalities in Lyme arthritis  

Science Conference Proceedings (OSTI)

Arthritis is a frequent manifestation of Lyme disease. Limited triple-phase Tc-99m MDP bone imaging of the wrists and hands with delayed whole-body images was performed in a patient with Lyme arthritis. This demonstrated abnormal joint uptake in the wrists and hands in all three phases, with increased activity seen in other affected joints on delayed whole-body images. These findings are nonspecific and have been previously described in a variety of rheumatologic conditions, but not in Lyme disease. Lyme disease should be considered in the differential diagnosis of articular and periarticular bone scan abnormalities.

Brown, S.J.; Dadparvar, S.; Slizofski, W.J.; Glab, L.B.; Burger, M. (Hahnemann Univ. Hospital, Philadelphia, PA (USA))

1989-10-01T23:59:59.000Z

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they are not comprehensive nor are they the most current set.
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81

Modelling and simulation of acrylic bone cement injection and curing within the framework of vertebroplasty  

E-Print Network (OSTI)

The minimal invasive procedure of vertebroplasty is a surgical technique to treat compression fractures of vertebral bodies. During the treatment liquid bone cement gets injected into the affected vertebral body and therein cures to a solid. In order to investigate the treatment and the impact of injected bone cement on the vertebra, an integrated modelling and simulation framework has been developed. The framework includes (i) the generation of computer models based on microCT images of human cancellous bone, (ii) CFD simulations of bone cement injection into the trabecular structure of a vertebral body as well as (iii) non-linear FEM simulations of the bone cement curing. Thereby, microstructural models of trabecular bone structures are employed. Furthermore, a detailed description of the material behaviour of acrylic bone cements is provided. More precisely, a non-linear fluid flow model is chosen for the representation of the bone cement behaviour during injection and a non-linear viscoelastic material mo...

Landgraf, Ralf; Kolmeder, Sebastian; Lion, Alexander; Lebsack, Helena; Kober, Cornelia

2013-01-01T23:59:59.000Z

82

Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins  

E-Print Network (OSTI)

Current treatment of bone defects due to trauma, cancer, or degenerative spine diseases involves the implantation of a bone graft. Autografts, which are harvested from the patient's own body, are associated with problems ...

Yong, Tseh-Hwan

2005-01-01T23:59:59.000Z

83

Intracellular calcium-expression-display (ICED) device operated by compressive stimulation of cells  

Science Conference Proceedings (OSTI)

The effects of steady compressive stimulation on intracellular calcium expression in MG-63 human osteoblast-like bone cells were examined using a fabricated micro cell chip with a microchannel array. A computer-controlled pneumatic system was used to ... Keywords: Cell chip, Compressive stress, Intracellular calcium-expression-display (ICED)

Tae Kyung Kim; Ok Chan Jeong

2012-10-01T23:59:59.000Z

84

Alpha-tricalcium phosphate-calcium sulfate hybrid bone cement ...  

Science Conference Proceedings (OSTI)

Presentation Title, Alpha-tricalcium phosphate-calcium sulfate hybrid bone ... electron scanning microscopy on the characterization of polymer coating ... Improving the Resistance to Contact and Flexural Damage of Ceramics Using Elastic Gradients ... using phosphoric acid activation by ultrasound and microwave radiation...

85

Porous coatings from wire mesh for bone implants  

DOE Patents (OSTI)

A method of coating areas of bone implant elements and the resulting implant having a porous coating are described. Preselected surface areas are covered by a preform made from continuous woven lengths of wire. The preform is compressed and heated to assure that diffusion bonding occurs between the wire surfaces and between the surface boundaries of the implant element and the wire surfaces in contact with it. Porosity is achieved by control of the resulting voids between the bonded wire portions.

Sump, Kenneth R. (Richland, WA)

1986-01-01T23:59:59.000Z

86

Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Synchrotron  

NLE Websites -- All DOE Office Websites (Extended Search)

Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Synchrotron Imaging Archaeopteryx specimens are important but extremely rare fossils. Due to their possession of both reptilian (jaws with teeth, long bony tail) and avian (feathered wings) characters, Archaeopteryx has been crucial in the development of Darwinian evolution. Despite their importance, no Archaeopteryx specimen has ever been chemically analyzed. This in large part may be explained by the analytical obstacles which preclude applying standard methods to such valuable specimens; destructive sampling is not an option and most non-destructive methods cannot handle large specimens. Furthermore, mapping using conventional methods is far too slow to enable chemical zonation to be reasonably determined. Mapping of trace element chemistry is of tremendous interest, however, because it opens a window into understanding several critical questions about Archaeopteryx in particular, and about fossil specimens in general. Preserved trace chemistry in bones and soft tissue may be remnants of the living organism, and therefore may give insight into life processes of extinct organisms. When mapping includes the embedding rock matrix, mass transfer between the fossil and the matrix can be constrained, hence giving information about mode of preservation. Chemical analysis can also resolve artefacts of the curation process. Finally, accurate chemical maps can also be useful for directing future work by highlighting regions that may be promising for other types of analysis including structural methods (CT, diffraction) or techniques that use other parts of the electromagnetic spectrum (infra-red).

87

Aging and Fracture of Human Cortical Bone and Tooth Dentin  

SciTech Connect

Mineralized tissues, such as bone and tooth dentin, serve as structural materials in the human body and, as such, have evolved to resist fracture. In assessing their quantitative fracture resistance or toughness, it is important to distinguish between intrinsic toughening mechanisms which function ahead of the crack tip, such as plasticity in metals, and extrinsic mechanisms which function primarily behind the tip, such as crack bridging in ceramics. Bone and dentin derive their resistance to fracture principally from extrinsic toughening mechanisms which have their origins in the hierarchical microstructure of these mineralized tissues. Experimentally, quantification of these toughening mechanisms requires a crack-growth resistance approach, which can be achieved by measuring the crack-driving force, e.g., the stress intensity, as a function of crack extension ("R-curve approach"). Here this methodology is used to study of the effect of aging on the fracture properties of human cortical bone and human dentin in order to discern the microstructural origins of toughness in these materials.

Ager, Joel; Koester, Kurt J.; Ager III, Joel W.; Ritchie, Robert O.

2008-05-07T23:59:59.000Z

88

Hypersensitivity of human and rodent Fanconi anemia (FA) cells to bystander  

NLE Websites -- All DOE Office Websites (Extended Search)

P.F. Wilson P.F. Wilson Brookhaven National Laboratory Abstract Fanconi anemia (FA) is a chromosomal instability and cancer predisposition syndrome characterized by developmental defects, progressive bone marrow failure, and cellular hypersensitivity to agents that induce DNA interstrand crosslinks and oxidative stress, including IR [1]. The disease is transmitted either as an autosomal-recessive or X-linked trait, and hypomorphic biallelic mutations in 15 FA and homologous recombinational repair (HRR) genes have been identified in FA patients (with more likely to be discovered). We have previously reported hypersensitivity of the isogenic fancg Chinese hamster ovary (CHO) mutant KO40 for sister chromatid exchange (SCE) induction following low-dose (<3 mGy) 3.86-MeV plutonium-238

89

3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone at the  

NLE Websites -- All DOE Office Websites (Extended Search)

3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone 3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone at the Nanoscale Scientists studying osteoporosis and other skeletal diseases are interested in the 3D structure of bone and its responses to conditions such as weightlessness, radiation (of particular interest to astronauts) and vitamin D deficiency. The current gold standard, micro-computed tomography (micro-CT), provides 3D images of trabeculae, the small interior struts of bone tissue, and electron microscopy can provide nanometer resolution of thin tissue slices. Hard X-ray transmission microscopy has provided the first 3D view of bone structure within individual trabeculae on the nanoscale. figure 1 Figure 1 Micro-CT (left) shows trabecular structure inside of bone. Transmission X-ray microscopy (TXM; center and right) can reveal localized details of osteocyte lacunae and their processes.

90

Butyl benzyl phthalate suppresses the ATP-induced cell proliferation in human osteosarcoma HOS cells  

Science Conference Proceedings (OSTI)

Butyl benzyl phthalate (BBP), an endocrine disruptor present in the environment, exerts its genomic effects via intracellular steroid receptors and elicits non-genomic effects by interfering with membrane ion-channel receptors. We previously found that BBP blocks the calcium signaling coupled with P2X receptors in PC12 cells (Liu and Chen, 2006). Osteoblast P2X receptors were recently reported to play a role in cell proliferation and bone remodeling. In this present study, the effects of BBP on ATP-induced responses were investigated in human osteosarcoma HOS cells. These receptors mRNA had been detected, named P2X4, P2X7, P2Y2, P2Y4, P2Y5, P2Y9, and P2Y11, in human osteosarcoma HOS cells by RT-PCR. The enhancement of cell proliferation and the decrease of cytoviability had both been shown to be coupled to stimulation via different concentrations of ATP. BBP suppressed the ATP-induced calcium influx (mainly coupled with P2X) and cell proliferation but not the ATP-induced intracellular calcium release (mainly coupled with P2Y) and cytotoxicity in human osteosarcoma HOS cells. Suramin, a common P2 receptor's antagonist, blocked the ATP-induced calcium signaling, cell proliferation, and cytotoxicity. We suggest that P2X is mainly responsible for cell proliferation, and P2Y might be partially responsible for the observed cytotoxicity. BBP suppressed the calcium signaling coupled with P2X, suppressing cell proliferation. Since the importance of P2X receptors during bone metastasis has recently become apparent, the possible toxic risk of environmental BBP during bone remodeling is a public problem of concern.

Liu, P.-S., E-mail: pslediting@mail.scu.edu.t [Department of Microbiology, Soochow University, Shihlin, Taipei, Taiwan (China); Chen, C.-Y. [Department of Microbiology, Soochow University, Shihlin, Taipei, Taiwan (China)

2010-05-01T23:59:59.000Z

91

Osteoporotic-like effects of cadmium on bone mineral density and content in aged ovariectomized beagles  

SciTech Connect

Our purpose was to evaluate the effects of ovariectomy in conjunction with cadmium (Cd) exposure on bone. Aged female beagles with {sup 45}Ca-labeled skeletons ovariectomized and exposed to Cd. Successive vertebral scans by dual photon absorptiometry monitored changes in bone mineral density (BMD) in each dog with time. Results showed that ovariectomy or Cd exposure alone caused significant decreases in BMD; ovariectomy with Cd exposure caused the greatest decrease. Ovariectomy alone did not decrease BMD in the distal end or mid-shaft of the tibia while BMD of the distal tibia decreased significantly due to Cd exposure alone. Combination treatment resulted in significant decreases in BMD of both tibial regions. At necropsy, tibiae, humeri, lumbar vertebrae and ribs were obtained for biochemical analysis. No group-to-group differences in bone weights (wet, dry, ash), in ash/dry ratios, or in long bone and vertebral Ca/dry or Ca/ash ratios were observed. Significantly higher total {sup 45}Ca content and {sup 45}Ca/dry and {sup 45}Ca/ash ratios were observed in long bones and vertebrae of OV- and OV+ groups. In contrast, intact ribs showed significantly decreased Ca/dry and Ca/ash ratios compared to the SO-group. Quartered ribs demonstrated regional responses to specific treatment; decreases in total Ca content were greatest in the mid-rib region ({minus}36 to {minus}46%). Results suggest that in the aged female beagle, bone mineral loss associated with estrogen depletion is not only related to bone type (trabecular versus cortical) but also to bone Ca pools. Our results also suggest that a regional heterogeneity of bone plays a role in responsiveness to ovariectomy and Cd exposure. These aspects suggest that Cd is an exogenous factor affecting bone mineral loss independently of estrogen depletion. However, estrogen depletion primes bone for responsiveness to Cd-induced bone mineral loss.

Sacco-Gibson, N.; Abrams, J.; Chaudhry, S.; Hurst, D.; Peterson, D.; Bhattacharyya, M.

1992-12-31T23:59:59.000Z

92

E13: An Experimentally-based Flow Stress Model for Cortical Bone  

Science Conference Proceedings (OSTI)

Developed here is a micro-scale-based flow stress model of cortical bone. In order to ... Catalysts by Using the Metal Ion-reducing Bacterium Shewanella Algae.

93

MICROSCOPIC METABOLISM OF CALCIUM IN BONE. III. MICRORADIOGRAPHIC MEASUREMENTS OF MINERAL DENSITY  

SciTech Connect

The range of microscopic calcium densities in man and in dog does not change wiih the age of the individual. The ranges, however. are not the same in the two species. New bone mineral in the dog is formed at higher density than similar mineral in man, and highly mineralized bone in the dog is more dense than the most dense bone in man. Thus species differcnces in calcium metabolism of bone do exist and should not be overlooked in the intercomparison of the uptake and retention of the alkaline earths in mammalian skeletons. (auth)

Rowland, R.E.; Jowsey, J.; Marshall, J.H.

1959-02-01T23:59:59.000Z

94

Proton Range Uncertainty Due to Bone Cement Injected Into the Vertebra in Radiation Therapy Planning  

Science Conference Proceedings (OSTI)

We wanted to evaluate the influence of bone cement on the proton range and to derive a conversion factor predicting the range shift by correcting distorted computed tomography (CT) data as a reference to determine whether the correction is needed. Two CT datasets were obtained with and without a bone cement disk placed in a water phantom. Treatment planning was performed on a set of uncorrected CT images with the bone cement disk, and the verification plan was applied to the same set of CT images with an effective CT number for the bone cement disk. The effective CT number was determined by measuring the actual proton range with the bone cement disk. The effects of CT number, thicknesses, and position of bone cement on the proton range were evaluated in the treatment planning system (TPS) to draw a conversion factor predicting the range shift by correcting the CT number of bone cement. The effective CT number of bone cement was 260 Hounsfield units (HU). The calculated proton range for native CT data was significantly shorter than the measured proton range. However, the calculated range for the corrected CT data with the effective CT number coincided exactly with the measured range. The conversion factor was 209.6 [HU . cm/mm] for bone cement and predicted the range shift by approximately correcting the CT number. We found that the heterogeneity of bone cement could cause incorrect proton ranges in treatment plans using CT images. With an effective CT number of bone cement derived from the proton range and relative stopping power, a more actual proton range could be calculated in the TPS. The conversion factor could predict the necessity for CT data correction with sufficient accuracy.

Lim, Young Kyung [Department of Radiation Oncology, Institute of Health Sciences, Gyeongsang National University, Jinju (Korea, Republic of); Hwang, Ui-Jung [Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Shin, Dongho, E-mail: dongho@ncc.re.kr [Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Kim, Dong Wook [Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Kwak, Jungwon [Department of Radiation Oncology, Asan Medical Center, Seoul (Korea, Republic of); Yoon, Myonggeun; Lee, Doo Hyun; Lee, Se Byeong; Lee, Sang-Yeob [Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Park, Sung Yong [Department of Radiation Oncology, Samsung Medical Center, Seoul (Korea, Republic of); Pyo, Hong Ryeol [Department of Radiation Oncology, Institute of Health Sciences, Gyeongsang National University, Jinju (Korea, Republic of); Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Department of Radiation Oncology, Asan Medical Center, Seoul (Korea, Republic of); Department of Radiation Oncology, Samsung Medical Center, Seoul (Korea, Republic of)

2011-10-01T23:59:59.000Z

95

Fracture, aging, and disease in bone J.W. Ager III  

E-Print Network (OSTI)

Fracture, aging, and disease in bone J.W. Ager III Materials Sciences Division, Lawrence Berkeley-known increase with age in fracture risk of human bone is essential. This also represents a challenge from accompanying the process of aging using appropriate multiscale experimental methods and relating them

Ritchie, Robert

96

Effect of aging on the toughness of human cortical bone: evaluation by R-curves  

E-Print Network (OSTI)

Effect of aging on the toughness of human cortical bone: evaluation by R-curves R.K. Nallaa,b , J online 27 October 2004 Abstract Age-related deterioration of the fracture properties of bone, coupled, and hence, an understanding of how its fracture properties degrade with age is essential. The present study

Ritchie, Robert

97

6BONE pTLA and pNLA Formats (pTLA)  

Science Conference Proceedings (OSTI)

This memo defines how the 6bone uses the 3FFE::/16 IPv6 address prefix, allocated in RFC 2471, "IPv6 Testing Address Allocation", [6BONE-TLA], to create pseudo Top-Level Aggregation Identifiers (pTLA's) and pseudo Next-Level Aggregation Identifiers ...

B. Fink

2000-09-01T23:59:59.000Z

98

Multiple verification in complex biological systems: the bone remodelling case study  

Science Conference Proceedings (OSTI)

We present a set of formal techniques and a methodology for a composite formal analysis at the tissue and organ level, focusing on the verification of quantitative properties in the process of bone remodelling. Starting from a differential equation model, ... Keywords: bone remodelling, formal analysis, model checking, piecewise multi-affine abstraction, sensitivity

Ezio Bartocci; Pietro Li; Emanuela Merelli; Nicola Paoletti

2012-01-01T23:59:59.000Z

99

Report from the Second Cytomegalovirus and Immunosenescence Workshop  

E-Print Network (OSTI)

, Thiel E, Volk HD, Scheibenbogen C: CMV-specific central memory T cells reside in bone marrow. Eur J Immunol 2007, 37:3063. 32. Libri V, Azevedo RI, Jackson SE, Di Mitri D, Lachmann R, Fuhrmann S, Vukmanovic-Stejic M, Yong K, Battistini L, Kern F, Soares...

Wills, Mark; Akbar, Arne; Beswick, Mark; Bosch, Jos A; Caruso, Calogero; Colonna-Romano, Giuseppina; Dutta, Ambarish; Franceschi, Claudio; Fulop, Tamas; Gkrania-Klotsas, Effrossyni; Goronzy, Joerg; Griffiths, Stephen J; Henson, Sian; Herndler-Brandstetter, Dietmar; Hill, Ann; Kern, Florian; Klenerman, Paul; Macallan, Derek; Macualay, Richard; Maier, Andrea B; Mason, Gavin; Melzer, David; Morgan, Matthew; Moss, Paul; Nikolich-Zugich, Janko; Pachnio, Annette; Riddell, Natalie; Roberts, Ryan; Sansoni, Paolo; Sauce, Delphine; Sinclair, John; Solana, Rafael; Strindhall, Jan; Trzonkowski, Piotr; van Lier, Rene; Vescovini, Rosanna; Wang, George; Westendorp, Rudi; Pawelec, Graham

2011-10-28T23:59:59.000Z

100

Permian Bone Spring formation: Sandstone play in the Delaware basin. Part I - slope  

SciTech Connect

New exploration in the Permian (Leonardian) Bone Spring formation has indicated regional potential in several sandstone sections across portions of the northern Delaware basin. Significant production has been established in the first, second, and third Bone Spring sandstones, as well as in a new reservoir interval, the Avalon sandstone, above the first Bone Spring sandstone. These sandstones were deposited as submarine-fan systems within the northern Delaware basin during periods of lowered sea level. The Bone Spring as a whole consists of alternating carbonate and siliciclastic intervals representing the downdip equivalents to thick Abo-Yeso/Wichita-Clear Fork carbonate buildups along the Leonardian shelf margin. Hydrocarbon exploration in the Bone Spring has traditionally focused on debris-flow carbonate deposits restricted to the paleoslope. Submarine-fan systems, in contrast, extend a considerable distance basinward of these deposits and have been recently proven productive as much as 40-48 km south of the carbonate trend.

Montgomery, S.L. [Petroleum Consultant, Seattle, WA (United States)

1997-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

The role of E2f4 in cell cycle exit and bone development  

E-Print Network (OSTI)

Members of the E2F family of transcription factors are critical downstream effectors of the pocket protein family and mediate the regulation of genes required for cellular proliferation. The repressive E2Fs act in association ...

Miller, Emily S. (Emily Sun Young)

2009-01-01T23:59:59.000Z

102

Mechanical Behavior of Biological Materials I: Bone and Teeth  

Science Conference Proceedings (OSTI)

Mar 4, 2013 ... These cells participate in the regenerative process through ... rise to overall loading-unloading hysteresis and cyclic dissipation of energy.

103

Cell separator and cell  

SciTech Connect

There is disclosed a novel cell separator made of a grafted membrane comprising a polyethylene film which is graft copolymerized with a monomer having an ion exchange group, characterized in that said membrane has an area which is not grafted at all or an area of low degree grafting. By making use of this membrane, a small size and thin cell having excellent performance as well as satisfactory mechanical strength can be produced at low cost with great advantages.

Ishigaki, I.; Machi, S.; Murata, K.; Okada, T.; Senoo, K.; Sugo, T.; Tanso, S.

1981-09-01T23:59:59.000Z

104

Bone dielectric property variation as a function of mineralization at microwave frequencies  

Science Conference Proceedings (OSTI)

A critical need exists for new imaging tools to more accurately characterize bone quality beyond the conventional modalities of dual energy X-ray absorptiometry (DXA), ultrasound speed of sound, and broadband attenuation measurements. In this paper we ...

Paul M. Meaney; Tian Zhou; Douglas Goodwin; Amir Golnabi; Elia A. Attardo; Keith D. Paulsen

2012-01-01T23:59:59.000Z

105

Geek-Up[6.10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

10.2011]: Thermoelectrics' Great Power, Key Ingredient in 10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's Nanostructure Geek-Up[6.10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's Nanostructure June 10, 2011 - 5:07pm Addthis Data image on lead telluride thermal conductivity | Photo Courtesy of Oak Ridge National Laboratory Data image on lead telluride thermal conductivity | Photo Courtesy of Oak Ridge National Laboratory Niketa Kumar Niketa Kumar Public Affairs Specialist, Office of Public Affairs What does this mean for me? Identifying a key ingredient in bone's nanostructure may help treat and prevent bone diseases such as osteoporosis and develop new light-weight, high-strength materials for innovative technologies. Advanced thermoelectric materials could be used to develop vehicle

106

Investigation of bone response to implant materials by electron microscopy and computer simulation  

E-Print Network (OSTI)

(cont.) implementation of this scintigraphic method for quantitative studies of osteoblast-mediated mineralization in vitro. A 2-D truss finite element model is used to study the remodeling of trabecular bone. Using strain ...

Wang, Hao, 1974-

2004-01-01T23:59:59.000Z

107

On the multiscale origins of fracture resistance in human bone and its biological degradation  

SciTech Connect

Akin to other mineralized tissues, human cortical bone can resist deformation and fracture due to the nature of its hierarchical structure, which spans the molecular to macroscopic length-scales. Deformation at the smallest scales, mainly through the composite action of the mineral and collagen, contributes to bone?s strength or intrinsic fracture resistance, while crack-tip shielding mechanisms active on the microstructural scale contribute to the extrinsic fracture resistance once cracking begins. The efficiency with which these structural features can resist fracture at both small and large length-scales becomes severely degraded with such factors as aging, irradiation and disease. Indeed aging and irradiation can cause changes to the cross-link profile at fibrillar length-scales as well as changes at the three orders of magnitude larger scale of the osteonal structures, both of which combine to inhibit the bone's overall resistance to the initiation and growth of cracks.

Zimmermann, Elizabeth A.; Barth, Holly D.; Ritchie, Robert O.

2012-03-09T23:59:59.000Z

108

Advances in Conjugated Linoleic Acid Research, Vol 2Chapter 13 CLA and Bone Modeling in Rats  

Science Conference Proceedings (OSTI)

Advances in Conjugated Linoleic Acid Research, Vol 2 Chapter 13 CLA and Bone Modeling in Rats Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry AOCS Press Downloadable pdf of Chapter 13 C

109

How Tough is Human Cortical Bone? In-Situ Measurements on Realistically Short Cracks  

SciTech Connect

Bone is more difficult to break than to split. Although this is well known, and many studies exist on the behavior of long cracks in bone, there is a need for data on the orientation-dependent crack-growth resistance behavior of human cortical bone which accurately assesses its toughness at appropriate size-scales. Here we use in-situ mechanical testing in the scanning electron microscope and x-ray computed tomography to examine how physiologically-pertinent short (<600 mu m) cracks propagate in both the transverse and longitudinal orientations in cortical bone, using both crack-deflection/twist mechanics and nonlinear-elastic fracture mechanics to determine crack-resistance curves. We find that after only 500 mu m of cracking, the driving force for crack propagation was more than five times higher in the transverse (breaking) direction than in the longitudinal (splitting) direction due to major crack deflections/twists principally at cement sheathes. Indeed, our results show that the true transverse toughness of cortical bone is far higher than previously reported. However, the toughness in the longitudinal orientation, where cracks tend to follow the cement lines, is quite low at these small crack sizes; it is only when cracks become several millimeters in length that bridging mechanisms can develop leading to the (larger-crack) toughnesses generally quoted for bone.

Ritchie, Robert O; Koester, K. J.; Ager III, J. W.; Ritchie, R.O.

2008-05-10T23:59:59.000Z

110

How Tough is Human Cortical Bone? In-Situ Measurements on Realistically Short Cracks  

Science Conference Proceedings (OSTI)

Bone is more difficult to break than to split. Although this is well known, and many studies exist on the behavior of long cracks in bone, there is a need for data on the orientation-dependent crack-growth resistance behavior of human cortical bone which accurately assesses its toughness at appropriate size-scales. Here we use in-situ mechanical testing in the scanning electron microscope and x-ray computed tomography to examine how physiologically-pertinent short (propagate in both the transverse and longitudinal orientations in cortical bone, using both crack-deflection/twist mechanics and nonlinear-elastic fracture mechanics to determine crack-resistance curves. We find that after only 500 mu m of cracking, the driving force for crack propagation was more than five times higher in the transverse (breaking) direction than in the longitudinal (splitting) direction due to major crack deflections/twists principally at cement sheathes. Indeed, our results show that the true transverse toughness of cortical bone is far higher than previously reported. However, the toughness in the longitudinal orientation, where cracks tend to follow the cement lines, is quite low at these small crack sizes; it is only when cracks become several millimeters in length that bridging mechanisms can develop leading to the (larger-crack) toughnesses generally quoted for bone.

Ritchie, Robert O; Koester, K. J.; Ager III, J. W.; Ritchie, R.O.

2008-05-10T23:59:59.000Z

111

Photovoltaic Cells  

Energy.gov (U.S. Department of Energy (DOE))

Photovoltaic (PV) cells, or solar cells, take advantage of the photoelectric effect to produce electricity. PV cells are the building blocks of all PV systems because they are the devices that...

112

Patterns of Practice in Palliative Radiotherapy for Painful Bone Metastases: A Survey in Japan  

Science Conference Proceedings (OSTI)

Purpose: To determine the current patterns of practice in Japan and to investigate factors that may make clinicians reluctant to use single-fraction radiotherapy (SF-RT). Methods and Materials: Members of the Japanese Radiation Oncology Study Group (JROSG) completed an Internet-based survey and described the radiotherapy dose fractionation they would recommend for four hypothetical cases describing patients with painful bone metastasis (BM). Case 1 described a patient with an uncomplicated painful BM in a non-weight-bearing site from non-small-cell lung cancer. Case 2 investigated whether management for a case of uncomplicated spinal BM would be different from that in Case 1. Case 3 was identical with Case 2 except for the presence of neuropathic pain. Case 4 investigated the prescription for an uncomplicated painful BM secondary to oligometastatic breast cancer. Radiation oncologists who recommended multifraction radiotherapy (MF-RT) for Case 2 were asked to explain why they considered MF-RT superior to SF-RT. Results: A total of 52 radiation oncologists from 50 institutions (36% of JROSG institutions) responded. In all four cases, the most commonly prescribed regimen was 30 Gy in 10 fractions. SF-RT was recommended by 13% of respondents for Case 1, 6% for Case 2, 0% for Case 3, and 2% for Case 4. For Case 4, 29% of respondents prescribed a high-dose MF-RT regimen (e.g., 50 Gy in 25 fractions). The following factors were most often cited as reasons for preferring MF-RT: 'time until first increase in pain' (85%), 'incidence of spinal cord compression' (50%), and 'incidence of pathologic fractures' (29%). Conclusions: Japanese radiation oncologists prefer a schedule of 30 Gy in 10 fractions and are less likely to recommend SF-RT. Most Japanese radiation oncologists regard MF-RT as superior to SF-RT, based primarily on the time until first increase in pain.

Nakamura, Naoki, E-mail: naokinak@luke.or.jp [Department of Radiation Oncology, St. Luke's International Hospital, Tokyo (Japan); Shikama, Naoto [Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka (Japan); Wada, Hitoshi [Department of Radiation Oncology, Miyagi Cancer Center, Natori (Japan); Harada, Hideyuki [Division of Radiation Oncology, Shizuoka Cancer Center, Mishima (Japan); Nozaki, Miwako [Department of Radiology, Dokkyo Medical University Koshigaya Hospital, Koshigaya (Japan); Nagakura, Hisayasu [Department of Radiology, KKR Sapporo Medical Center, Sapporo (Japan); Tago, Masao [Department of Radiology, Teikyo University Mizonokuchi Hospital, Kawasaki (Japan); Oguchi, Masahiko [Department of Radiation Oncology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo (Japan); Uchida, Nobue [Department of Radiation Oncology, Shimane University Hospital, Izumo (Japan)

2012-05-01T23:59:59.000Z

113

cell tree  

Science Conference Proceedings (OSTI)

NIST. cell tree. (data structure). ... Concave objects are decomposed into convex pieces. Each convex piece is indexed in every cell which it overlaps. ...

2013-05-08T23:59:59.000Z

114

The Deep-Sea Natural Products, Biogenic Polyphosphate (Bio-PolyP) and Biogenic Silica (Bio-Silica), as Biomimetic Scaffolds for Bone Tissue Engineering: Fabrication of a Morphogenetically-Active Polymer  

E-Print Network (OSTI)

Abstract: Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likewise challenging to develop bone substitution materials to heal bone defects. During the differentiation of osteoblasts from their mesenchymal progenitor/stem cells and of osteoclasts from their hemopoietic precursor cells, a lineage-specific release of growth factors and a trans-lineage homeostatic cross-talk via signaling molecules take place. Hence, the major hurdle is to fabricate a template that is functioning in a way mimicking the morphogenetic, inductive role(s) of the native extracellular matrix. In the last few years, two naturally occurring polymers that are produced by deep-sea sponges, the biogenic polyphosphate (bio-polyP) and biogenic silica (bio-silica) have also been identified as promoting morphogenetic on both osteoblasts andMar. Drugs 2013, 11 719

Xiaohong Wang; Heinz C. Schrder; Qingling Feng; Florian Draenert; Werner E. G. Mller

2013-01-01T23:59:59.000Z

115

Fuel Cell Technologies Office: Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Cells Search Search Help Fuel Cells EERE Fuel Cell Technologies Office Fuel Cells Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Fuel...

116

Cytogenetic effects of shale-derived oils and related by-products in mice  

DOE Green Energy (OSTI)

The cytogenetic effects of exposure to crude shale oil by either skin painting or intraperitoneal injectional and transplacental exposure of embryos to water derived from surface retort processing of shale oil were analyzed. Exposure to crude shale oils from two sources, Paraho and Occidental, by skin painting had essesntially no effect on the frequency of chromosomal aberrations in bone marrow cells. Intraperitoneal injection of the Paraho crude shale oil increased the frequency of chromosome damage in bone marrow cells at all three doses tested (0.5 ml, 1.0 ml, and 2.0 ml/kg). Metaphase analysis of cells from embryos at day 12 gestation from females that had been exposed to 1% Paraho retort water ad libitum from day 1 of gestation indicated that clastogenic compounds present in this water can cross the placenta and induce chromosomal damage in embryonic cells.

Meyne, J.; Deaven, L.L.

1980-07-01T23:59:59.000Z

117

Aortoesophageal Fistula and Aortic Pseudoaneurysm Induced by Swallowed Fish Bone: A Report of Two Cases  

Science Conference Proceedings (OSTI)

Esophageal perforation caused by accidental swallowing of fish bones can lead to rare complications, such as aortoesophageal fistula accompanied by aortic pseudoaneurysm, which can be fatal if not properly handled. We report two rare cases of aortoesophageal fistula and aortic pseudoaneurysm caused by esophagus perforation after accidental swallow of fish bone; the patients also had purulent mediastinitis and esophagitis. The treatment of aortic pseudoaneurysm was successful in both cases, with one patient undergoing surgical resection and aortic neoplasty and the other patient undergoing endovascular stent graft placement. Long-term antibiotic treatment was administered to both patients after surgery. There were no postsurgical complications, and the patients recovered without incident.

Chen Aiping, E-mail: chenaiping-123@163.com; Yu Hong, E-mail: yuhongphd@163.com [Second Military Medical University, Department of Radiology, Changzheng Hospital (China); Li Huimin [Shanghai Jiaotong University School of Medicine, Department of Radiology, Xinhua Hospital (China); Xiao Xiangsheng, E-mail: cjr.xxsh@vip163.com; Liu Shiyuan [Second Military Medical University, Department of Radiology, Changzheng Hospital (China)

2011-02-15T23:59:59.000Z

118

Calcium balance and bone density in immature horses fed a high protein diet  

E-Print Network (OSTI)

Studies in other species indicate high protein diets increase urinary calcium (Ca) excretion and may lead to negative calcium balance and reduced bone density. As overfeeding of protein is commonplace in the horse industry, this study was undertaken to determine the effects of excess dietary protein on growth, physiologic response, mineral balance, bone density, and bone geometry in immature horses. Sixteen 10-month-old American Quarter Horses were blocked by age and sex into two dietary treatments. The control diet was formulated to provide the NRC (1989) recommended concentration of crude protein, while the high protein diet provided 130% of NRC (1989) recommendations. All other nutrients were formulated at or slightly above NRC (1989) recommendations. Blood samples, feces, and urine were collected during the 116-day study to determine any diet effect on pH and mineral balance. Radiographs were made of the left third metacarpal (MCIII) to determine bone density via radiographic bone aluminum equivalence (RBAE), and bone geometry was determined metrically from the radiographs. Urine pH decreased over time (p < 0.001), but there were no diet effects on blood pH or urine pH. Conversely, when normalized to day 0 values, fecal pH was reduced by feeding the high protein treatment (p < 0.02). Density of dorsal and palmar cortices increased over time (p < 0.001), but no differences were observed between diets. But, normalized total medial-lateral (ML) width of the MCIII was higher in the control diet (p < 0.05). Fecal Ca loss was greater in horses fed the high protein diet (p < 0.005), while Ca absorption and retention were lower for horses on the high protein treatment (p < 0.02). Phosphorus (P) balance was not different between diets, although feeding the high protein diet resulted in higher P intake overall (p < 0.001). While excess dietary protein may decrease fecal pH, increase fecal Ca excretion, and decrease Ca absorption and retention, there was no consistent effect of the high protein diet on bone density over the course of this study. Further research is necessary to determine if feeding high-protein diets is detrimental to bone quality in the growing horse.

Spooner, Holly Sue

2005-08-01T23:59:59.000Z

119

Fuel Cell Technologies Office: Fuel Cells  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Efficiency and Renewable Energy EERE Home | Programs & Offices | Consumer Information Fuel Cells Search Search Help Fuel Cells EERE Fuel Cell Technologies Office Fuel Cells...

120

Diopside (CaO-MgO-2SiO2)-fluorapatite (9CaO-3P2O5-CaF2) glass-ceramics: Potential materials for bone tissue engineering  

SciTech Connect

Glass-ceramics in the diopside (CaMgSi2O6) - fluorapatite [Ca5(PO4)3F] system are potential candidates for restorative dental and bone implant materials. In the present study, a series of glasses along diopside - fluorapatite binary system have been prepared with varying diopside/fluorapatite ratios for their potential applications in bone tissue engineering. The glasses were obtained from compositions with fluorapatite contents varying between 0-40 wt.%. The sintering ability and crystallization kinetics of as obtained amorphous glasses have been studied through hot-stage microscopy (HSM) and differential thermal analysis (DTA), respectively while crystalline phase evolution in sintered GCs has been followed by X-ray diffraction (XRD) adjoined with Rietveld-R.I.R. technique and scanning electron microscopy (SEM). Further, biodegradation and apatite forming ability of glass-ceramics were investigated by immersion of glass-ceramic discs in simulated body fluid (SBF) solution while chemical degradation and weight loss of glass-ceramics were studied by immersion in Tris-HCl in accordance with standard ISO 10993-14. The addition of fluorapatite (10-25 wt.%) in diopside glass system significantly enhanced the sintering ability of glass-ceramics and improved their apatite forming ability along with their biodegradation behaviour. Moreover, the in vitro cellular responses to glass-ceramics showed good cell viability and significant stimulation of osteoblastic differentiation, suggesting the possible use of the glass-ceramics for bone regeneration.

Kansal, Ishu; Goel, Ashutosh; Tulyaganov, Dilshat U.; Pascual, Maria J.; Lee, Hye-Young; Kim, Hae-Won; Ferreira, Jose M.

2011-08-18T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Refinement of the $n-\\alpha$ and $p-\\alpha$ fish-bone potential  

E-Print Network (OSTI)

The fishbone potential of composite particles simulates the Pauli effect by nonlocal terms. We determine the $n-\\alpha$ and $p-\\alpha$ fish-bone potential by simultaneously fitting to the experimental phase shifts. We found that with a double Gaussian parametrization of the local potential can describe the $n-\\alpha$ and $p-\\alpha$ phase shifts for all partial waves.

Smith, E; Papp, Z

2012-01-01T23:59:59.000Z

122

Instrument for bone mineral measurement using a microprocessor as the control and arithmetic element  

SciTech Connect

A self-contained instrument for the determination of bone mineral content by photon absorptometry is described. A high-resolution detection system allows measurements to be made at up to 16 photon energies. Control and arithmetic functions are performed by a microprocessor. Analysis capability and limitations are discussed. (auth)

Alberi, J.L.; Hardy, W.H. II

1975-11-01T23:59:59.000Z

123

Effects of Vibrator Types and Their Placement on Bone?Conduction Threshold Measurements  

Science Conference Proceedings (OSTI)

Monaural bone?conduction threshold measurements in the quiet were obtained for 10 normally hearing young adults at both forehead and mastoid positions using two hearing?aid?type vibrators of different manufacture. Physical calibration data for the vibrators were obtained by other laboratories

Peter B. Weston; Roy W. Gengel; Ira J. Hirsh

1966-01-01T23:59:59.000Z

124

Effectiveness of Reirradiation for Painful Bone Metastases: A Systematic Review and Meta-Analysis  

Science Conference Proceedings (OSTI)

Purpose: Reirradiation of painful bone metastases in nonresponders or patients with recurrent pain after initial response is performed in up to 42% of patients initially treated with radiotherapy. Literature on the effect of reirradiation for pain control in those patients is scarce. In this systematic review and meta-analysis, we quantify the effectiveness of reirradiation for achieving pain control in patients with painful bone metastases. Methods and Materials: A free text search was performed to identify eligible studies using the MEDLINE, EMBASE, and the Cochrane Collaboration library electronic databases. After study selection and quality assessment, a pooled estimate was calculated for overall pain response for reirradiation of metastatic bone pain. Results: Our literature search identified 707 titles, of which 10 articles were selected for systematic review and seven entered the meta-analysis. Overall study quality was mediocre. Of the 2,694 patients initially treated for metastatic bone pain, 527 (20%) patients underwent reirradiation. Overall, a pain response after reirradiation was achieved in 58% of patients (pooled overall response rate 0.58, 95% confidence interval = 0.49-0.67). There was a substantial between-study heterogeneity (I{sup 2} = 63.3%, p = 0.01) because of clinical and methodological differences between studies. Conclusions: Reirradiation of painful bone metastases is effective in terms of pain relief for a small majority of patients; approximately 40% of patients do not benefit from reirradiation. Although the validity of results is limited, this meta-analysis provides a comprehensive overview and the most quantitative estimate of reirradiation effectiveness to date.

Huisman, Merel, E-mail: m.huisman-7@umcutrecht.nl [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands)] [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands); Bosch, Maurice A.A.J. van den; Wijlemans, Joost W. [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands)] [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands); Vulpen, Marco van [Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands)] [Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands); Linden, Yvette M. van der [Department of Clinical Oncology, Leiden University Medical Center, Leiden (Netherlands)] [Department of Clinical Oncology, Leiden University Medical Center, Leiden (Netherlands); Verkooijen, Helena M. [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands)] [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands)

2012-09-01T23:59:59.000Z

125

Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cells Fuel Cells Converting chemical energy of hydrogenated fuels into electricity Project Description Invented in 1839, fuels cells powered the Gemini and Apollo space missions, as well as the space shuttle. Although fuel cells have been successfully used in such applications, they have proven difficult to make more cost-effective and durable for commercial applications, particularly for the rigors of daily transportation. Since the 1970s, scientists at Los Alamos have managed to make various scientific breakthroughs that have contributed to the development of modern fuel cell systems. Specific efforts include the following: * Finding alternative and more cost-effective catalysts than platinum. * Enhancing the durability of fuel cells by developing advanced materials and

126

Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cells Fuel Cells The Solid State Energy Conversion Alliance (SECA) program is responsible for coordinating Federal efforts to facilitate development of a commercially relevant and robust solid oxide fuel cell (SOFC) system. Specific objectives include achieving an efficiency of greater than 60 percent, meeting a stack cost target of $175 per kW, and demonstrating lifetime performance degradation of less than 0.2 percent per

127

Fuel Cells  

Energy.gov (U.S. Department of Energy (DOE))

Fuel cells are an emerging technology that can provide heat and electricity for buildings and electrical power for vehicles and electronic devices.

128

Electrochemical cell  

Science Conference Proceedings (OSTI)

An electrochemical cell is disclosed that has a lithium anode, a thionyl chloride depolarizer and a sulphur dioxide passivation control agent which further includes having the pressure relieved to substantially reduce the internal pressure of the cell. The internal cell pressure is relieved by venting for sufficient time at an elevated temperature to reduce the internal cell pressure to less than five psi at room temperature, preferably by a plurality of venting cycles and a temperature ranging from room temperature to the elevated temperature. Normally, the elevated temperature ranges from at least 100/sup 0/ to greater than 150/sup 0/ F.

Chua, D.L.; Garoutte, K.F.; Levy, L.L.

1982-11-23T23:59:59.000Z

129

Fuel Cell Technologies Office: Fuel Cell Animation  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cell Animation to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Animation on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Animation on...

130

Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Materials Science » Materials Science » Fuel Cells Fuel Cells Research into alternative forms of energy, especially energy security, is one of the major national security imperatives of this century. Get Expertise Melissa Fox Applied Energy Email Catherine Padro Sensors & Electrochemical Devices Email Fernando Garzon Sensors & Electrochemical Devices Email Piotr Zelenay Sensors & Electrochemical Devices Email Rod Borup Sensors & Electrochemical Devices Email Karen E. Kippen Experimental Physical Sciences Email Like a battery, a fuel cell consists of two electrodes separated by an electrolyte-in polymer electrolyte fuel cells, the separator is made of a thin polymeric membrane. Unlike a battery, a fuel cell does not need recharging-it continues to produce electricity as long as fuel flows

131

Changes in hemopoiesis and survival of mice exposed to long-term radiation. [Gamma radiation  

SciTech Connect

A study was made of the change in colony-forming capacity and total number of bone marrow cells, amount of cellular elements in peripheral blood and survival of continuously irradiated mice (dose rates of 25, 50 and 80 R/day). At dose rates of 25 and 50 R/day, after an initial decline of CFU (colony-forming units), bone marrow cells, blood lymphocytes and thrombocytes, there was stabilization; there was no appreciable change in amount of erythrocytes and granulocytes. There was general disruption of hemopoiesis with a dose of 80 R/day. Mean survival time constituted 132.8 days at a dose rate of 50 R/day and 43.3 days at the rate of 80 R/day.

Kalina, I.; Praslicka, M.

1977-01-01T23:59:59.000Z

132

Aluminum silicate nanotube coating of siloxane-poly(lactic acid)-vaterite composite fibermats for bone regeneration  

Science Conference Proceedings (OSTI)

In our earlier work, a flexible fibermat consisting of a biodegradable composite with soluble silicate species, which has been reported to enhance bone formation, was prepared successfully using poly(L-lactic acid) and siloxane-containing calcium carbonate ...

Shuji Yamazaki, Hirotaka Maeda, Akiko Obata, Keiichi Inukai, Katsuya Kato, Toshihiro Kasuga

2012-01-01T23:59:59.000Z

133

Flaxseed in Human Nutrition, 2nd EditionChapter 17 Effect of Flaxseed on Bone Metabolism and Menopauseolism and Menopause  

Science Conference Proceedings (OSTI)

Flaxseed in Human Nutrition, 2nd Edition Chapter 17 Effect of Flaxseed on Bone Metabolism and Menopause olism and Menopause Food Science Health Nutrition Biochemistry eChapters Food Science & Technology Health - Nutrition - Biochemistry

134

Potential commercial application of a bi-layer bone-ligament regeneration scaffold to anterior cruciate ligament replacement  

E-Print Network (OSTI)

A business model was created in order to explore the commercial application of a bi-layer bone-ligament scaffold to the treatment of torn anterior cruciate ligaments (ACL) requiring replacement. The two main keys in producing ...

Li, Jessica C. (Jessica Ching-Yi)

2006-01-01T23:59:59.000Z

135

Three dimensional modeling and analysis of Haversian systems in compact bone tissue  

E-Print Network (OSTI)

This study provides a qualitative as well as quantitative characterization of the geometry and architecture of the Haversian systems at a microscopic level. A procedure was developed and employed to generate a three dimensional computer model from serial sections of equine bone. From the reconstruction, quantitative calculations were made. including porosity. surface areas. cross sectional areas, anci cross sectional shapes. Also the porosity due to Volkmann canals was estimated. Other more qualitative calculations included the nature of branching. termination. taper'n-and-general osteon movement. Any chance in the specimen size or shape during, the entire processing-was carefully documented and corrected for where possible. One of the goals of the research was to assess and evaluate the procedures developed and identify ways to further improve accuracy. With a computerized three dimensional imag-e of the bone microstructure. detailed calculations can be made and insig-ht cained more accurately than with two dimensional models or past three dimensional models.

Deisseroth, Kate

1995-01-01T23:59:59.000Z

136

Cell Image Visualization  

Science Conference Proceedings (OSTI)

... Biological cell image analysis projects include methods to measure cell segmentation accuracy and new segmentation methods to track live cells. ...

2011-06-17T23:59:59.000Z

137

Imaging the Material Properties of Bone Specimens Using Reflection-Based Infrared Microspectroscopy  

Science Conference Proceedings (OSTI)

Fourier transform infrared microspectroscopy (FTIRM) is a widely used method for mapping the material properties of bone and other mineralized tissues, including mineralization, crystallinity, carbonate substitution, and collagen cross-linking. This technique is traditionally performed in a transmission-based geometry, which requires the preparation of plastic-embedded thin sections, limiting its functionality. Here, we theoretically and empirically demonstrate the development of reflection-based FTIRM as an alternative to the widely adopted transmission-based FTIRM, which reduces specimen preparation time and broadens the range of specimens that can be imaged. In this study, mature mouse femurs were plastic-embedded and longitudinal sections were cut at a thickness of 4 {micro}m for transmission-based FTIRM measurements. The remaining bone blocks were polished for specular reflectance-based FTIRM measurements on regions immediately adjacent to the transmission sections. Kramers-Kronig analysis of the reflectance data yielded the dielectric response from which the absorption coefficients were directly determined. The reflectance-derived absorbance was validated empirically using the transmission spectra from the thin sections. The spectral assignments for mineralization, carbonate substitution, and collagen cross-linking were indistinguishable in transmission and reflection geometries, while the stoichiometric/nonstoichiometric apatite crystallinity parameter shifted from 1032/1021 cm{sup -1} in transmission-based to 1035/1025 cm{sup -1} in reflection-based data. This theoretical demonstration and empirical validation of reflection-based FTIRM eliminates the need for thin sections of bone and more readily facilitates direct correlations with other methods such as nanoindentation and quantitative backscatter electron imaging (qBSE) from the same specimen. It provides a unique framework for correlating bone's material and mechanical properties.

Acerbo A. S.; Carr, G.L.; Judex, S.; Miller, L.M.

2012-03-13T23:59:59.000Z

138

Adapting the polycarbonate dosimeter and electrochemical etching to the microdosimetry of /sup 239/Pu in bone  

SciTech Connect

The problem of setting the maximum permissible body burden, MPBB, for /sup 239/Pu is a complex one. Recent papers have been published which favor lowering the MPBB by varying factors depending on the assumptions used. /sup 239/Pu has been shown quite clearly, on detailed autoradiograph, to concentrate on the trabecular surfaces of the endosteal face of osseous tissue. This realization led the ICRP to propose the alteration of the MPBB for /sup 239/Pu in a manner based upon microdosimetry of /sup 239/Pu in bone, i.e., determine the dose out to 10..mu..m from the bone surfaces. Unfortunately, microdosimetry fulfilling this requirement has not been available. We are working toward this objective utilizing the Lexan polycarbonate detector and our optimized electrochemical etching procedure to amplify plutonium alpha tracks. As a prerequisite to this work, we are studying three problems inherently present in the Lexan detector. They involve achieving a very low background of tracks on the foils and a high degree of reproducibility between etching batches at this background level. Thirdly, we are determining the factor by which to multiply the number of induced tracks/cm/sup 2/ (..cap alpha.. and recoil) to obtain dose equivalent (rem). In this calibration we are using a standard /sup 239/Pu source and a surface barrier detection system. The plutonium bearing bones used in the microdosimetry phase of this research are rat, dog, and human.

Stillwagon, G.B.; Su, S.J.; Morgan, K.Z.

1977-01-01T23:59:59.000Z

139

Cell mitosis  

NLE Websites -- All DOE Office Websites (Extended Search)

of the nuclear membrane in each of the daughter cells would conclude the cycle. Chromatin needs to uncoil and key genes become active again via transcription of mRNA. Lou...

140

Electrochemical cell  

DOE Patents (OSTI)

An electrochemical cell is described having a bimodal positive electrode, a negative electrode of an alkali metal, and a compatible electrolyte including an alkali metal salt molten at the cell operating temperature. The positive electrode has an electrochemically active layer of at least one transition metal chloride at least partially present as a charging product, and additives of bromide and/or iodide and sulfur in the positive electrode or the electrolyte. Electrode volumetric capacity is in excess of 400 Ah/cm{sup 3}; the cell can be 90% recharged in three hours and can operate at temperatures below 160 C. There is also disclosed a method of reducing the operating temperature and improving the overall volumetric capacity of an electrochemical cell and for producing a positive electrode having a BET area greater than 6{times}10{sup 4}cm{sup 2}/g of Ni. 6 figs.

Redey, L.I.; Vissers, D.R.; Prakash, J.

1996-07-16T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Electrochemical cell  

DOE Patents (OSTI)

An electrochemical cell having a bimodal positive electrode, a negative electrode of an alkali metal, and a compatible electrolyte including an alkali metal salt molten at the cell operating temperature. The positive electrode has an electrochemically active layer of at least one transition metal chloride at least partially present as a charging product, and additives of bromide and/or iodide and sulfur in the positive electrode or the electrolyte. Electrode volumetric capacity is in excess of 400 Ah/cm.sup.3 ; the cell can be 90% recharged in three hours and can operate at temperatures below 160.degree. C. There is also disclosed a method of reducing the operating temperature and improving the overall volumetric capacity of an electrochemical cell and for producing a positive electrode having a BET area greater than 6.times.10.sup.4 cm.sup.2 /g of Ni.

Redey, Laszlo I. (Downers Grove, IL); Vissers, Donald R. (Naperville, IL); Prakash, Jai (Downers Grove, IL)

1994-01-01T23:59:59.000Z

142

Electrochemical cell  

DOE Patents (OSTI)

An electrochemical cell having a bimodal positive electrode, a negative electrode of an alkali metal, and a compatible electrolyte including an alkali metal salt molten at the cell operating temperature. The positive electrode has an electrochemically active layer of at least one transition metal chloride at least partially present as a charging product, and additives of bromide and/or iodide and sulfur in the positive electrode or the electrolyte. Electrode volumetric capacity is in excess of 400 Ah/cm.sup.3 ; the cell can be 90% recharged in three hours and can operate at temperatures below 160.degree. C. There is also disclosed a method of reducing the operating temperature and improving the overall volumetric capacity of an electrochemical cell and for producing a positive electrode having a BET area greater than 6.times.10.sup.4 cm.sup.2 /g of Ni.

Redey, Laszlo I. (6851 Carpenter St., Downers Grove, IL 60516); Vissers, Donald R. (611 Clover Ct., Naperville, IL 60540); Prakash, Jai (2205 Arbor Cir. 8, Downers Grove, IL 60515)

1996-01-01T23:59:59.000Z

143

Load cell  

DOE Patents (OSTI)

A load cell combines the outputs of a plurality of strain gauges to measure components of an applied load. Combination of strain gauge outputs allows measurement of any of six load components without requiring complex machining or mechanical linkages to isolate load components. An example six axis load cell produces six independent analog outputs, each directly proportional to one of the six general load components. 16 figs.

Spletzer, B.L.

1998-12-15T23:59:59.000Z

144

Load cell  

DOE Patents (OSTI)

A load cell combines the outputs of a plurality of strain gauges to measure components of an applied load. Combination of strain gauge outputs allows measurement of any of six load components without requiring complex machining or mechanical linkages to isolate load components. An example six axis load cell produces six independent analog outputs which can be combined to determine any one of the six general load components.

Spletzer, Barry L. (Albuquerque, NM)

2001-01-01T23:59:59.000Z

145

Load cell  

DOE Patents (OSTI)

A load cell combines the outputs of a plurality of strain gauges to measure components of an applied load. Combination of strain gauge outputs allows measurement of any of six load components without requiring complex machining or mechanical linkages to isolate load components. An example six axis load cell produces six independent analog outputs, each directly proportional to one of the six general load components.

Spletzer, Barry L. (Albuquerque, NM)

1998-01-01T23:59:59.000Z

146

Electrochemical cell  

DOE Patents (OSTI)

An electrochemical cell having an alkali metal negative electrode such as sodium and a positive electrode including Ni or transition metals, separated by a .beta." alumina electrolyte and NaAlCl.sub.4 or other compatible material. Various concentrations of a bromine, iodine and/or sulfur containing additive and pore formers are disclosed, which enhance cell capacity and power. The pore formers may be the ammonium salts of carbonic acid or a weak organic acid or oxamide or methylcellulose.

Redey, Laszlo I. (Downers Grove, IL); Vissers, Donald R. (Naperville, IL); Prakash, Jai (Downers Grove, IL)

1994-01-01T23:59:59.000Z

147

Radiobiological Basis for the Whole Body Radiation Syndrome  

SciTech Connect

Data are presented that show a marked species difference in the degree of damage and in the course of events seen in the bone marrow and peripheral blood after a given dose of radiation. The data taken together indicate strongly, but do not prove, that the picture seen results primarily from damage to the stem cell population. This damage to the stem cells is manifested later in the more mature differentiating cells of the marrow, and in the peripheral blood. The picture seen results both from death of stem cells, and also injury leading to reduced proliferative capacity, with later death of the injured stem cell and all of its progeny. Thus the picture seen is a result of both quantitative and qualitative changes resulting directly from the exposure of the stem cells, and species differences relative to sensitivity and time course of events appear to depend to a large degree on differential sensitivity of the bone marrow stem cell populations to death and injury. (auth)

Bond, V.P.; Fliedner, T.M.

1963-07-19T23:59:59.000Z

148

DOEIEV-0005/33 ANL-OHS/HP-82-104 FORMERLY UTILIZED MED/AEC SITES  

Office of Legacy Management (LM)

to the gonads, lung, and bone marrow, respectively. Contributions from the use of fossil fuels (natural gas and coal) and nuclear reactors; mining, milling, and tailings...

149

DOEIEV.0005/35 ANL-OHS/HP-83403 FORMERLY UTILIZED MEDIAEC SITES  

Office of Legacy Management (LM)

to the gonads, lung, and bone marrow, respectively. Contributions from the use of fossil fuels (natural gas and coal) and nuclear reactors; mining, milling, and tailings...

150

AN L=OHS/HP=84.108 FORMERLY UTILIZED MEDIAEC SITES REMEDIAL ACTION...  

Office of Legacy Management (LM)

to the gonads, lung, and bone marrow, respectively. Contributions from the use of fossil fuels (natural gas and coal) and nuclear reactors; mining, milling, and tailings...

151

Hematogical lesions as a function of dosage of long-term radiation  

Science Conference Proceedings (OSTI)

The quantitative patterns of damage to the blood system in the course of prolonged exposure to the ionizing radiation inherent in space were studied as well as the time characteristics of development of lesions in different blast elements. An effort was made to determine the minimal volume of hematological tests during long-term exposure to radiation to assess the general state of the blood system, on the basis of comparison of dynamics of changes in bone marrow and peripheral blood. Experiments were conducted on 285 mongrel rats weighing 180 to 200 g. The animals were exposed to radiation at dose rates of 300, 100, and 50 R/day. They were exposed continuously for 22-23/day. Analysis of the findings revealed that the dynamics of decline in total number of bone marrow cells during the phase of primary depletion is governed by an exponential law. There was distinct demonstration of the effects of cumulative dose and dose rate. A typical finding in all cell populations of bone marrow was an initial exponential decline in number of cells.

Gorlov, V.G.; Neyman, O.V.

1982-03-01T23:59:59.000Z

152

Clonal evolution following chemotherapy-induced stem cell depletion in cats heterozygous for glucose-6-phosphate dehydrogenase  

SciTech Connect

The number of hematopoietic stem cells necessary to support normal hematopoiesis is not known but may be small. If so, the depletion or damage of such cells could result in apparent clonal dominance. To test this hypothesis, dimethylbusulfan (2 to 4 mg/kg intravenously (IV) x 3) was given to cats heterozygous for the X-linked enzyme glucose-6-phosphate dehydrogenase (G-6-PD). These cats were the daughters of domestic X Geoffroy parents. After the initial drug-induced cytopenias (2 to 4 weeks), peripheral blood counts and the numbers of marrow progenitors detected in culture remained normal, although the percentages of erythroid burst-forming cells (BFU-E) and granulocyte/macrophage colony-forming cells (CFU-GM) in DNA synthesis increased, as determined by the tritiated thymidine suicide technique. In three of six cats treated, a dominance of Geoffroy-type G-6-PD emerged among the progenitor cells, granulocytes, and RBCs. These skewed ratios of domestic to Geoffroy-type G-6-PD have persisted greater than 3 years. No changes in cell cycle kinetics or G-6-PD phenotypes were noted in similar studies in six control cats. These data suggest that clonal evolution may reflect the depletion or damage of normal stem cells and not only the preferential growth and dominance of neoplastic cells.

Abkowitz, J.L.; Ott, R.M.; Holly, R.D.; Adamson, J.W.

1988-06-01T23:59:59.000Z

153

Electrochemical cell  

DOE Patents (OSTI)

This invention is comprised of an electrochemical cell has a layer-type or sandwich configuration with a Teflon center section that houses working, reference and counter electrodes and defines a relatively narrow electrolyte cavity. The center section is surrounded on both sides with thin Teflon membranes. The membranes are pressed in place by a pair of Teflon inner frames which are in turn supported by a pair of outer metal frames. The pair of inner and outer frames are provided with corresponding, appropriately shaped slits that are in plane generally transverse to the plane of the working electrode and permit X-ray beams to enter and exit the cell through the Teflon membranes that cover the slits so that the interface between the working electrode and the electrolyte within the cell may be analyzed by transmission geometry. In one embodiment, the center section consists of two parts, one on top of the other. Alternatively, the center section of the electrochemical cell may consist of two intersliding pieces or may be made of a single piece of Teflon sheet material. The electrolyte cavity is shaped so that the electrochemical cell can be rotated 900 in either direction while maintaining the working-and counter electrodes submerged in the electrolyte.

Nagy, Z.; Yonco, R.M.; You, Hoydoo; Melendres, C.A.

1991-04-23T23:59:59.000Z

154

Electrochemical cell  

DOE Patents (OSTI)

An electrochemical cell has a layer-type or sandwich configuration with a Teflon center section that houses working, reference and counter electrodes and defines a relatively narrow electrolyte cavity. The center section is surrounded on both sides with thin Teflon membranes. The membranes are pressed in place by a pair of Teflon inner frames which are in turn supported by a pair of outer metal frames. The pair of inner and outer frames are provided with corresponding, appropriately shaped slits that are in plane generally transverse to the plane of the working electrode and permit X-ray beams to enter and exit the cell through the Teflon membranes that cover the slits so that the interface between the working electrode and the electrolyte within the cell may be analyzed by transmission geometry. In one embodiment, the center section consists of two parts, one on top of the other. Alternatively, the center section of the electrochemical cell may consist of two intersliding pieces or may be made of a single piece of Teflon sheet material. The electrolyte cavity is shaped so that the electrochemical cell can be rotated 90[degree] in either direction while maintaining the working and counter electrodes submerged in the electrolyte. 5 figs.

Nagy, Z.; Yonco, R.M.; You, H.; Melendres, C.A.

1992-08-25T23:59:59.000Z

155

Age-related changes in the plasticity and toughness of human cortical bone at multiple length-scales  

SciTech Connect

The structure of human cortical bone evolves over multiple length-scales from its basic constituents of collagen and hydroxyapatite at the nanoscale to osteonal structures at nearmillimeter dimensions, which all provide the basis for its mechanical properties. To resist fracture, bones toughness is derived intrinsically through plasticity (e.g., fibrillar sliding) at structural-scales typically below a micron and extrinsically (i.e., during crack growth) through mechanisms (e.g., crack deflection/bridging) generated at larger structural-scales. Biological factors such as aging lead to a markedly increased fracture risk, which is often associated with an age-related loss in bone mass (bone quantity). However, we find that age-related structural changes can significantly degrade the fracture resistance (bone quality) over multiple lengthscales. Using in situ small-/wide-angle x-ray scattering/diffraction to characterize sub-micron structural changes and synchrotron x-ray computed tomography and in situ fracture-toughness measurements in the scanning electron microscope to characterize effects at micron-scales, we show how these age-related structural changes at differing size-scales degrade both the intrinsic and extrinsic toughness of bone. Specifically, we attribute the loss in toughness to increased non-enzymatic collagen cross-linking which suppresses plasticity at nanoscale dimensions and to an increased osteonal density which limits the potency of crack-bridging mechanisms at micron-scales. The link between these processes is that the increased stiffness of the cross-linked collagen requires energy to be absorbed by plastic deformation at higher structural levels, which occurs by the process of microcracking.

Zimmermann, Elizabeth A.; Schaible, Eric; Bale, Hrishikesh; Barth, Holly D.; Tang, Simon Y.; Reichert, Peter; Busse, Bjoern; Alliston, Tamara; Ager III, Joel W.; Ritchie, Robert O.

2011-08-10T23:59:59.000Z

156

Electrochemical cell  

DOE Patents (OSTI)

An electrochemical cell is described having an alkali metal negative electrode such as sodium and a positive electrode including Ni or transition metals, separated by a [beta] alumina electrolyte and NaAlCl[sub 4] or other compatible material. Various concentrations of a bromine, iodine and/or sulfur containing additive and pore formers are disclosed, which enhance cell capacity and power. The pore formers may be the ammonium salts of carbonic acid or a weak organic acid or oxamide or methylcellulose. 6 figs.

Redey, L.I.; Vissers, D.R.; Prakash, J.

1994-08-23T23:59:59.000Z

157

Photovoltaic cell  

DOE Patents (OSTI)

In a photovoltaic cell structure containing a visibly transparent, electrically conductive first layer of metal oxide, and a light-absorbing semiconductive photovoltaic second layer, the improvement comprising a thin layer of transition metal nitride, carbide or boride interposed between said first and second layers.

Gordon, Roy G. (Cambridge, MA); Kurtz, Sarah (Somerville, MA)

1984-11-27T23:59:59.000Z

158

Photoelectrodialytic cell  

DOE Patents (OSTI)

A multicompartment photoelectrodialytic demineralization cell is provided with a buffer compartment interposed between the product compartment and a compartment containing an electrolyte solution. Semipermeable membranes separate the buffer compartment from the product and electrolyte compartments. The buffer compartment is flushed to prevent leakage of the electrolyte compartment from entering the product compartment.

Murphy, George W. (2328 Ashwood, Norman, OK 73069)

1983-01-01T23:59:59.000Z

159

A method to detect transfected chloramphenicol acetyltransferase gene expression in intact animals  

SciTech Connect

A rapid procedure is described for assaying chloramphenicol acetyltransferase enzyme activity in intact animals following transfection of the RSV CAT plasmid into mouse bone marrow cells by electroporation. The reconstituted mice were injected with ({sup 14}C)chloramphenicol and ethyl acetate extracts of 24-h urine samples were analyzed by TLC autoradiography for the excretion of {sup 14}C-labeled metabolites. CAT expression in vivo can be detected by the presence of acetylated {sup 14}C-labeled metabolites in the urine within 1 week after bone marrow transplantation and, under the conditions described, these metabolites can be detected for at least 3 months. CAT expression in intact mice as monitored by the urine assay correlates with the CAT expression in the hematopoietic tissues assayed in vitro. This method offers a quick mode of screening for introduced CAT gene expression in vivo without sacrificing the mice.

Narayanan, R.; Jastreboff, M.M.; Chiu, Chang Fang; Ito, Etsuro; Bertino, J.R. (Memorial Sloan-Kettering Cancer Center, New York, NY (USA))

1988-01-01T23:59:59.000Z

160

X-band EPR imaging as a tool for gradient dose reconstruction in irradiated bones  

SciTech Connect

Purpose: Various tools are currently available for dose reconstruction in individuals after accidental exposure to ionizing radiation. Among the available biological analyses, Monte Carlo simulations, and biophysical methods, such as electron paramagnetic resonance (EPR), the latter has proved its usefulness for retrospective dosimetry. Although EPR spectroscopy is probably the most sensitive technique, it does not provide spatial dosimetric data. This information is, however, highly desirable when steep dose gradient irradiations are involved. The purpose of this work was to explore the possibilities of EPR imaging (EPRI) for spatial dose reconstruction in irradiated biological material. Methods: X-band EPRI was used to reconstruct ex vivo the relative dose distribution in human bone samples and hydroxyapatite phantoms after irradiation with brachytherapy seeds or x rays. Three situations were investigated: Homogeneous, stepwise gradient, and continuous gradient irradiation. Results: EPRI gave a faithful relative spin density distribution in bone samples and in hydroxyapatite phantoms. Measured dose ratios were in close agreement with the actual delivered dose ratios. EPRI was able to distinguish the dose gradients induced by two different sources ({sup 125}I and {sup 192}Ir). However, the measured spatial resolution of the system was 1.9 mm and this appeared to be a limiting factor. The method could be improved by using new signal postprocessing strategies. Conclusions: This study demonstrates that EPRI can be used to assess the regional relative dose distribution in irradiated bone samples. The method is currently applicable to ex vivo measurements of small size samples with low variation in tissue density but is likely to be adapted for in vivo application using L-band EPRI.

Leveque, Philippe; Godechal, Quentin; Bol, Anne; Trompier, Francois; Gallez, Bernard [Biomedical Magnetic Resonance Unit, Universite catholique de Louvain, B-1200 Brussels (Belgium); Molecular Imaging and Experimental Radiotherapy Unit, Universite catholique de Louvain, B-1200 Brussels (Belgium); Institut de Surete Nucleaire et de Radioprotection, F-92262 Fontenay-aux-Roses (France); Biomedical Magnetic Resonance Unit, Universite catholique de Louvain, B-1200 Brussels (Belgium)

2009-09-15T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Level of osteopenia and bone recovery in alcohol-fed adolescent rats  

E-Print Network (OSTI)

Adolescence is a period in human growth and development that is a time of rapid and drastic change. It is also known to be an age of widespread alcohol abuse. Studies addressing the reversibility of the deleterious effects of chronic alcohol consumption on young, actively growing adolescent bones have not been done. The objective of this study was to determine the level of bone recovery, if any, once an adolescent ceases alcohol consumption. Fifty, 4-week old, female, Sprague-Dawley rats were individually housed and maintained in an American Association for the Accreditation of Laboratory Animal Care-accredited facility at Texas A&M. The rats (n = 6 or 7 per group) were fed either alcohol (35% ethanol-derived calories), isocaloric liquid diet, or chow for 2 or 4 weeks, depending on the experimental group. The weekly blood alcohol concentrations averaged 309 [] 9 mg/dl. The rats were sacrificed 2 and 4 weeks after the experimental feeding began. The BioQuant Morphometric System was used to perform the histomorphometric analyses of the proximal tibia. Tibia bone volume per trabecular volume (BV/TV) in both age groups of alcohol and pair-fed animals was significantly less when compared to the chow 4 week animals. BV/TV was increased in the alcohol recovery group when compared to the alcohol 2 and 4 week groups, but the level of growth never reached the chow-fed 4 week group. Femur length, diameter and volume measurements increased in the alcohol recovery group when compared to both the alcohol 2 and 4 week groups. However, the length and volume parameters did not fully recover to equal those of the control chow 4 week animals, or even the some-age pair-fed animals. Femur diameter of the alcohol recovery animals was comparable to the alcohol 4 week animals, but less than the chow-fed. Alcohol also suppressed IGF-I levels. Full bone recovery did not occur within two weeks after removal of alcohol from the diet, suggesting the detrimental effects due to alcohol were not completely reversible during this time frame.

Spears, Heather Lynae

1999-01-01T23:59:59.000Z

162

Nanocrystal Solar Cells  

E-Print Network (OSTI)

research on organic photovoltaic cells since small molecule10 years prior (4). Photovoltaic cells with an active layerof the associated photovoltaic cells. 2.4 Charge transport

Gur, Ilan

2006-01-01T23:59:59.000Z

163

Regional geologic characterization of the Second Bone Spring Sandstone, Delaware basin, Lea and Eddy Counties, New Mexico  

E-Print Network (OSTI)

The Bone Spring Formation is a series of interbedded siliciclastics and carbonates that were deposited in the Delaware basin during the Leonardian (Early Permian). It consists of the First, Second and Third Carbonate and the First, Second and Third Sandstone, as well as the informally named Avalon Sandstone. The Second Bone Spring Sandstone, the focus of the study, can be subdivided into 4 distinct sand bodies separated by pelagic zones. These sands are designated the A-D Sands. The depositional patterns of the Bone Spring Formation are reflective of the underlying structure that resulted from compression during the Mississippian and Pennsylvanian. The Second Bone Spring Sandstone (specifically the C Sand) is essentially a dolomitic, coarse siltstone that is composed of facies reflective of deposition by turbidity currents in a slope fan environment. The midfan, levee/overbank and hemipelagic environments of deposition identified in the Second Bone Spring Sandstone are consistent with those of the typical slope fan of Walker (1978). The slope fans of the C Sand were confined by north-to-south trending reverse faults, which inhibited lateral migration of both the fans and the channels within them. The A-D Sands are correlatable throughout the study area but thicken in the underlying structural lows. These thicker sands are lobate in plan view and are located adjacent to, rather than directly on top of, underlying thick sands. This is likely a result of differential compaction of underlying sediment which served to further confine the fans. The sediment comprising the Second Bone Spring Sandstone was likely transported through basinward migration of sand dunes in an arid environment during relative sea level lowstands. Periodically, brief rises in sea level choked off sediment supply allowing hemipelagic material to be draped over underlying sands. With sea level fall, sands were again deposited in the tectonic sub-basins.

Downing, Amanda Beth

2001-01-01T23:59:59.000Z

164

Fuel Cell Technologies Office: Fuel Cell Animation  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

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165

Corrosion and Electrochemical Cells  

Science Conference Proceedings (OSTI)

Table 1   Cell conditions for commercial and industrial electrode processes...fuel cells Electrolytic e cell > e cell,rev I ? 0 (impressed current

166

Electrorefining cell evaluation  

SciTech Connect

Operational characteristics of the LANL electrorefining cell, a modified LANL electrorefining cell, and an advanced electrorefining cell (known as the CRAC cell) were determined. Average process yields achieved were: 75% for the LANL cell, 82% for the modified LANL cell, and 86% for the CRAC cell. All product metal from the LANL and modified LANL cells was within foundry specifications. Metal from one run in the CRAC cell exceeded foundry specifications for tantalum. The LANL and modified LANL cells were simple in design and operation, but product separation was more labor intensive than with the CRAC cell. The CRAC cell was more complicated in design but remained relatively simple in operation. A decision analysis concluded that the modified LANL cell was the preferred cell. It was recommended that the modified LANL cell be implemented by the Plutonium Recovery Project at Rocky Flats and that development of the CRAC cell continue. 8 refs., 22 figs., 12 tabs.

Bronson, M.C.; Thomas, R.L. (ed.)

1989-04-14T23:59:59.000Z

167

Bone lead content assessed by L-line x-ray fluorescence in lead-exposed and non-lead-exposed suburban populations in the United States  

SciTech Connect

Measurements of lead (Pb) in bone reflect cumulative Pb exposure, whereas blood Pb levels are indices of absorption during the previous 21-30 days. This study was undertaken to estimate bone Pb concentrations by L-line x-ray fluorescence (LXRF) in a United States suburban population which was exposed to unusually high levels of Pb in emissions from an adjacent factory during 1963-1981, compared with concentrations similarly estimated in a matched suburban community without unusual Pb exposure. The mean bone Pb value in 269 residents of the highly exposed suburb (15 ppm) was 3-fold greater than that of the reference suburb (5 ppm). LXRF estimates of bone Pb identified those individuals at risk for adverse effects of Pb, whereas blood Pb levels were uninformative. Average LXRF-estimated bone Pb concentrations in residents of the unusually exposed suburb approximated estimated values in workers at Pb-processing factories. 44 refs., 1 fig., 1 tab.

Rosen, J.F.; Balbi, K.; Balbi, J.; Bailey, C.; Clemente, I.; Redkey, N.; Grainger, S. (Albert Einstein College of Medicine, Bronx, NY (United States)); Crocetti, A.F. (New York Medical College, Valhalla (United States))

1993-04-01T23:59:59.000Z

168

Microfluidic Cell Culture  

Science Conference Proceedings (OSTI)

... microfluidic device with access to optical imaging, electrochemical interrogation, controlled lysis of desired cells, and collection of cell contents for ...

2012-10-01T23:59:59.000Z

169

Chloroquine Improves Survival and Hematopoietic Recovery After Lethal Low-Dose-Rate Radiation  

SciTech Connect

Purpose: We have previously shown that the antimalarial agent chloroquine can abrogate the lethal cellular effects of low-dose-rate (LDR) radiation in vitro, most likely by activating the ataxia-telangiectasia mutated (ATM) protein. Here, we demonstrate that chloroquine treatment also protects against lethal doses of LDR radiation in vivo. Methods and Materials: C57BL/6 mice were irradiated with a total of 12.8 Gy delivered at 9.4 cGy/hour. ATM null mice from the same background were used to determine the influence of ATM. Chloroquine was administered by two intraperitoneal injections of 59.4 {mu}g per 17 g of body weight, 24 hours and 4 hours before irradiation. Bone marrow cells isolated from tibia, fibula, and vertebral bones were transplanted into lethally irradiated CD45 congenic recipient mice by retroorbital injection. Chimerism was assessed by flow cytometry. In vitro methylcellulose colony-forming assay of whole bone marrow cells and fluorescence activated cell sorting analysis of lineage depleted cells were used to assess the effect of chloroquine on progenitor cells. Results: Mice pretreated with chloroquine before radiation exhibited a significantly higher survival rate than did mice treated with radiation alone (80% vs. 31%, p = 0.0026). Chloroquine administration before radiation did not affect the survival of ATM null mice (p = 0.86). Chloroquine also had a significant effect on the early engraftment of bone marrow cells from the irradiated donor mice 6 weeks after transplantation (4.2% vs. 0.4%, p = 0.015). Conclusion: Chloroquine administration before radiation had a significant effect on the survival of normal but not ATM null mice, strongly suggesting that the in vivo effect, like the in vitro effect, is also ATM dependent. Chloroquine improved the early engraftment of bone marrow cells from LDR-irradiated mice, presumably by protecting the progenitor cells from radiation injury. Chloroquine thus could serve as a very useful drug for protection against the harmful effects of LDR radiation.

Lim Yiting [Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)] [Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Hedayati, Mohammad; Merchant, Akil A.; Zhang Yonggang; Yu, Hsiang-Hsuan M. [Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)] [Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Kastan, Michael B. [Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee (United States) [Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee (United States); Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina (United States); Matsui, William, E-mail: matsuwi@jhmi.edu [Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)] [Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); DeWeese, Theodore L., E-mail: deweete@jhmi.edu [Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)

2012-11-01T23:59:59.000Z

170

Induction of Genomic Instability In Vivo by Low Doses of 137Cs gamma rays  

SciTech Connect

The overall goal of this project is to determine if low doses (below or equal to the level traditionally requiring human radiation protection, i.e. less than or equal to 10 cGy) of low LET radiation can induce genomic instability. The magnitude of genomic instability was measured as delayed chromosome instability in bone marrow cells of exposed mice with different levels of endogenous DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity, i.e. high (C57BL/6J mice), intermediate (BALB/cJ mice), and extremely low (Scid mice). In addition, at early time points (1 and 4 hrs) following irradiation, levels of activation of nuclear factor-kappa B (NF-{kappa}B), a transcription factor known to be involved in regulating the expression of genes responsible for cell protection following stimuli, were measured in these cells. Bone marrow cells were collected at different times following irradiation, i.e. 1 hr, 4 hrs, 1 month, and 6 months. A total of five mice per dose per strain were sacrificed at each time point for sample collection. As a result, a total of 80 mice from each strain were used. The frequency and the type of metaphase chromosome aberrations in bone marrow cells collected from exposed mice at different times following irradiation were used as markers for radiation-induced genomic instability. A three-color fluorescence in situ hybridization (FISH) protocol for mouse chromosomes 1, 2, and 3 was used for the analysis of delayed stable chromosomal aberrations in metaphase cells. All other visible chromatid-type aberrations and gross structural abnormalities involving non-painted chromosomes were also evaluated on the same metaphase cells used for scoring the stable chromosomal aberrations of painted chromosomes. Levels of nuclear factor-kappa B (NF-{kappa}B) activation were also determined in cells at 1 and 4 hrs following irradiation (indicative of early responses).

Rithidech, Kanokporn; Simon, Sanford, R.; Whorton, Elbert, B.

2006-01-06T23:59:59.000Z

171

Validation of mutual information-based registration of CT and bone SPECT images in dual-isotope studies  

Science Conference Proceedings (OSTI)

The registration of computed tomography (CT) and nuclear medicine (NM) images can substantially enhance patient diagnosis as it allows for the fusion of anatomical and functional information, as well as the attenuation correction of NM images. However, ... Keywords: Accuracy, Bone SPECT, Dual-isotope studies, Multi-modality registration, Multi-resolution, Mutual information, Precision, Qualitative evaluation, Quantitative validation, Reproducibility, Robustness, Sensitivity

Lisa Tang; Ghassan Hamarneh; Anna Celler

2008-11-01T23:59:59.000Z

172

Photoelectrochemical cell  

DOE Patents (OSTI)

A photoelectrochemical cell comprising a sealed container having a light-transmitting window for admitting light into the container across a light-admitting plane, an electrolyte in the container, a photoelectrode in the container having a light-absorbing surface arranged to receive light from the window and in contact with the electrolyte, the surface having a plurality of spaced portions oblique to the plane, each portion having dimensions at least an order of magnitude larger than the maximum wavelength of incident sunlight, the total surface area of the surface being larger than the area of the plane bounded by the container, and a counter electrode in the container in contact with the electrolyte.

Rauh, R. David (Newton, MA); Boudreau, Robert A. (Norton, MA)

1983-06-14T23:59:59.000Z

173

Dosimetric verification of the anisotropic analytical algorithm in lung equivalent heterogeneities with and without bone equivalent heterogeneities  

SciTech Connect

Purpose: In this study, the authors evaluated the accuracy of dose calculations performed by the convolution/superposition based anisotropic analytical algorithm (AAA) in lung equivalent heterogeneities with and without bone equivalent heterogeneities. Methods: Calculations of PDDs using the AAA and Monte Carlo simulations (MCNP4C) were compared to ionization chamber measurements with a heterogeneous phantom consisting of lung equivalent and bone equivalent materials. Both 6 and 10 MV photon beams of 4x4 and 10x10 cm{sup 2} field sizes were used for the simulations. Furthermore, changes of energy spectrum with depth for the heterogeneous phantom using MCNP were calculated. Results: The ionization chamber measurements and MCNP calculations in a lung equivalent phantom were in good agreement, having an average deviation of only 0.64{+-}0.45%. For both 6 and 10 MV beams, the average deviation was less than 2% for the 4x4 and 10x10 cm{sup 2} fields in the water-lung equivalent phantom and the 4x4 cm{sup 2} field in the water-lung-bone equivalent phantom. Maximum deviations for the 10x10 cm{sup 2} field in the lung equivalent phantom before and after the bone slab were 5.0% and 4.1%, respectively. The Monte Carlo simulation demonstrated an increase of the low-energy photon component in these regions, more for the 10x10 cm{sup 2} field compared to the 4x4 cm{sup 2} field. Conclusions: The low-energy photon by Monte Carlo simulation component increases sharply in larger fields when there is a significant presence of bone equivalent heterogeneities. This leads to great changes in the build-up and build-down at the interfaces of different density materials. The AAA calculation modeling of the effect is not deemed to be sufficiently accurate.

Ono, Kaoru; Endo, Satoru; Tanaka, Kenichi; Hoshi, Masaharu; Hirokawa, Yutaka [Department of Radiation Physics, Hiroshima Heiwa Clinic, 1-31 Kawaramachi, Naka-ku, Hiroshima 730-0856 (Japan); Quantum Energy Applications, Graduate School of Engineering, Hiroshima University, 4-1 Kagamiyama, Higashi-Hiroshima 730-8527 (Japan); Center of Medical Education, Sapporo Medical University, 17 Minami 1 Jo, Chuo-ku, Sapporo 060-8556 (Japan); Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553 (Japan); Department of Radiation Oncology, Hiroshima Heiwa Clinic, 1-31 Kawaramachi, Naka-ku, Hiroshima 730-0856 (Japan)

2010-08-15T23:59:59.000Z

174

Percutaneous Vertebroplasty and Bone Cement Leakage: Clinical Experience with a New High-Viscosity Bone Cement and Delivery System for Vertebral Augmentation in Benign and Malignant Compression Fractures  

Science Conference Proceedings (OSTI)

The aim of this study was to assess the feasibility of and venous leakage reduction in percutaneous vertebroplasty (PV) using a new high-viscosity bone cement (PMMA). PV has been used effectively for pain relief in osteoporotic and malignant vertebral fractures. Cement extrusion is a common problem and can lead to complications. Sixty patients (52 female; mean age, 72.2 {+-} 7.2) suffering from osteoporosis (46), malignancy (12), and angiomas (2), divided into two groups (A and B), underwent PV on 190 vertebrae (86 dorsal, 104 lumbar). In Group A, PV with high-viscosity PMMA (Confidence, Disc-O-Tech, Israel) was used. This PMMA was injected by a proprietary delivery system, a hydraulic saline-filled screw injector. In Group B, a standard low-viscosity PMMA was used. Postprocedural CT was carried out to detect PMMA leakages and complications. Fisher's exact test and Wilcoxon rank test were used to assess significant differences (p PV was feasible, achieving good clinical outcome (p < 0.0001) without major complications. In Group A, postprocedural CT showed an asymptomatic leak in the venous structures of 8 of 98 (8.2%) treated vertebrae; a discoidal leak occurred in 6 of 98 (6.1%). In Group B, a venous leak was seen in 38 of 92 (41.3%) and a discoidal leak in 12 of 92 (13.0%). Reduction of venous leak obtained by high-viscosity PMMA was highly significant (p < 0.0001), whereas this result was not significant (p = 0.14) related to the disc. The high-viscosity PMMA system is safe and effective for clinical use, allowing a significant reduction of extravasation rate and, thus, leakage-related complications.

Anselmetti, Giovanni Carlo, E-mail: giovanni.anselmetti@ircc.i [Institute for Cancer Research and Treatment (IRCC), Interventional Radiology Unit (Italy); Zoarski, Gregg [University of Maryland, Radiology and Radiological Science (United States); Manca, Antonio [Institute for Cancer Research and Treatment (IRCC), Radiology Unit (Italy); Masala, Salvatore [University 'Tor Vergata', Radiology Unit and Interventional Radiology Unit (Italy); Eminefendic, Haris; Russo, Filippo; Regge, Daniele [Institute for Cancer Research and Treatment (IRCC), Radiology Unit (Italy)

2008-09-15T23:59:59.000Z

175

The first cell sorter  

NLE Websites -- All DOE Office Websites (Extended Search)

The first cell sorter The first cell sorter 1663 Los Alamos science and technology magazine Latest Issue:November 2013 All Issues » submit The first cell sorter About fifty years ago, a Los Alamos scientist invented a method-still important in cellular biology labs today-to separate out particular types of cells. November 25, 2013 The first cell sorter Flow cytometry (cell measurement) uses cell sorting to divert cells of a chosen type out of a mixed stream of cells, like the blood cells shown here, for collection and study. Los Alamos invented, and has regularly improved upon, the technology to isolate different kinds of cells. In the early-mid 1960s, Los Alamos physicist Mack Fulwyler invented a device to isolate different types of cells. His invention, still a vital aspect of flow cytometry (cell measurement) in biological laboratories

176

Fuel cell arrangement  

DOE Patents (OSTI)

A fuel cell arrangement is provided wherein cylindrical cells of the solid oxide electrolyte type are arranged in planar arrays where the cells within a plane are parallel. Planes of cells are stacked with cells of adjacent planes perpendicular to one another. Air is provided to the interior of the cells through feed tubes which pass through a preheat chamber. Fuel is provided to the fuel cells through a channel in the center of the cell stack; the fuel then passes the exterior of the cells and combines with the oxygen-depleted air in the preheat chamber.

Isenberg, Arnold O. (Forest Hills Boro, PA)

1987-05-12T23:59:59.000Z

177

Fuel cell arrangement  

DOE Patents (OSTI)

A fuel cell arrangement is provided wherein cylindrical cells of the solid oxide electrolyte type are arranged in planar arrays where the cells within a plane are parallel. Planes of cells are stacked with cells of adjacent planes perpendicular to one another. Air is provided to the interior of the cells through feed tubes which pass through a preheat chamber. Fuel is provided to the fuel cells through a channel in the center of the cell stack; the fuel then passes the exterior of the cells and combines with the oxygen-depleted air in the preheat chamber. 3 figs.

Isenberg, A.O.

1987-05-12T23:59:59.000Z

178

Tiny Conspiracies: cell-to-cell communication in bacteria  

Science Conference Proceedings (OSTI)

Tiny Conspiracies: cell-to-cell communication in bacteria. Purpose: Bacteria, primitive single-celled organisms, communicate ...

2012-11-13T23:59:59.000Z

179

Fuel Cell Links  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cell Links Fuel Cell Links The links below are provided as additional resources for fuel-cell-related information. Most of the linked sites are not part of, nor affiliated with, fueleconomy.gov. We do not endorse or vouch for the accuracy of the information found on such sites. Fuel Cell Vehicles and Manufacturers Chevrolet General Motors press release about the Chevrolet Fuel Cell Equinox Ford Ford overview of their hydrogen fuel cell vehicles Honda FCX Clarity official site Hyundai Hyundai press release announcing the upcoming Tucson Fuel Cell Mercedes-Benz Ener-G-Force Fuel-cell-powered concept SUV Nissan Nissan TeRRA concept SUV Toyota Overview of Toyota fuel cell technology Hydrogen- and Fuel-Cell-Related Information and Tools Fuel Cell Vehicles Brief overview of fuel cell vehicles provided by DOE's Alternative Fuels Data Center (AFDC)

180

NETL: Fuel Cells - Contacts  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel CellsSolid State Energy Conversion Alliance (SECA) Contacts For information on the Fuel CellsSECA program, contact: Fuel Cells Technology Manager: Shailesh Vora 412-386-7515...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Energy Basics: Fuel Cells  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

EERE: Energy Basics Fuel Cells Photo of two hydrogen fuel cells. Fuel cells are an emerging technology that can provide heat and electricity for buildings and electrical power for...

182

Nanocrystal Solar Cells  

E-Print Network (OSTI)

Nov, 2005). Chapter 4 Hybrid solar cells with 3-dimensional5 All-inorganic nanocrystal solar cells 5.1 Introduction Inoperation of organic based solar cells and distinguish them

Gur, Ilan

2006-01-01T23:59:59.000Z

183

Hydrogen Fuel Cell Vehicles  

E-Print Network (OSTI)

Operation of a Solid Polymer Fuel Cell: A Parametric Model,"1991). G. Bronoel, "Hydrogen-Air Fuel Cells Without PreciousG. Abens, "Development of a Fuel Cell Power Source for Bus,"

Delucchi, Mark

1992-01-01T23:59:59.000Z

184

Energy Basics: Fuel Cells  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Energy Basics Renewable Energy Printable Version Share this resource Biomass Geothermal Hydrogen Hydrogen Fuel Fuel Cells Hydropower Ocean Solar Wind Fuel Cells Photo of...

185

Parabolic cell analyzer  

SciTech Connect

The disclosure is directed to a cell analysis apparatus incorporating a paraboloidal cavity for maximum utilization for improved cell characteristic monitoring.

Salzman, Gary C. (Los Alamos, NM); Skogen Hagenson, Mary J. (Los Alamos, NM)

1980-01-01T23:59:59.000Z

186

Photovoltaic Cell Materials  

Energy.gov (U.S. Department of Energy (DOE))

Although crystalline silicon cells are the most common type, photovoltaic (PV), or solar cells, can be made of many semiconductor materials. Each material has unique strengths and characteristics...

187

Nanomechanics and ultrastructural studies of cortical bone : fundamental insights regarding structure-function, mineral-organic force mechanics interactions, and heterogeneity  

E-Print Network (OSTI)

Although the mechanics of bone has been studied extensively at the micro- and macro-scale, the nano-scopic level is perhaps the most illuminating as this is the length scale at which the individual constituents interact. ...

Tai, Kuangshin

2007-01-01T23:59:59.000Z

188

Fuel Cell Technologies Office: Fuel Cell Technical Publications  

NLE Websites -- All DOE Office Websites (Extended Search)

Cell Technical Cell Technical Publications to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technical Publications on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technical Publications on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technical Publications on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technical Publications on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technical Publications on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technical Publications on AddThis.com... Publications Program Publications Technical Publications Hydrogen Fuel Cells Safety, Codes & Standards Market Analysis Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings

189

A Signal-Inducing Bone Cement for Magnetic Resonance Imaging-Guided Spinal Surgery Based on Hydroxyapatite and Polymethylmethacrylate  

Science Conference Proceedings (OSTI)

The aim of this study was to develop a signal-inducing bone cement for magnetic resonance imaging (MRI)-guided cementoplasty of the spine. This MRI cement would allow precise and controlled injection of cement into pathologic lesions of the bone. We mixed conventional polymethylmethacrylate bone cement (PMMA; 5 ml methylmethacrylate and 12 g polymethylmethacrylate) with hydroxyapatite (HA) bone substitute (2-4 ml) and a gadolinium-based contrast agent (CA; 0-60 {mu}l). The contrast-to-noise ratio (CNR) of different CA doses was measured in an open 1.0-Tesla scanner for fast T1W Turbo-Spin-Echo (TSE) and T1W TSE pulse sequences to determine the highest signal. We simulated MRI-guided cementoplasty in cadaveric spines. Compressive strength of the cements was tested. The highest CNR was (1) 87.3 (SD 2.9) in fast T1W TSE for cements with 4 {mu}l CA/ml HA (4 ml) and (2) 60.8 (SD 2.4) in T1W TSE for cements with 1 {mu}l CA/ml HA (4 ml). MRI-guided cementoplasty in cadaveric spine was feasible. Compressive strength decreased with increasing amounts of HA from 46.7 MPa (2 ml HA) to 28.0 MPa (4 ml HA). An MRI-compatible cement based on PMMA, HA, and CA is feasible and clearly visible on MRI images. MRI-guided spinal cementoplasty using this cement would permit direct visualization of the cement, the pathologic process, and the anatomical surroundings.

Wichlas, Florian, E-mail: florian.wichlas@charite.de; Seebauer, Christian J.; Schilling, Rene [University Charite, Center for Musculoskeletal Surgery (Germany); Rump, Jens [University Charite, Department of Radiology (Germany); Chopra, Sascha S. [University Charite, Center for Musculoskeletal Surgery (Germany); Walter, Thula; Teichgraeber, Ulf K. M. [University Charite, Department of Radiology (Germany); Bail, Hermann J. [University Charite, Center for Musculoskeletal Surgery (Germany)

2012-06-15T23:59:59.000Z

190

Innovative Composites Through Reinforcement Morphology Design - a Bone-Shaped-Short-Fiber Composite  

Science Conference Proceedings (OSTI)

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objective of this project is to improve the strength and toughness of conventional short-fiber composites by using innovative bone-shaped-short (BSS) fibers as reinforcement. We fabricated a model polyethylene BSS fiber-reinforced polyester-matrix composite to prove that fiber morphology, instead of interfacial strength, solves the problem. Experimental tensile and fracture toughness test results show that BSS fibers can bridge matrix cracks more effectively, and consume many times more energy when pulled out, than conventional-straight-short (CSS) fibers. This leads to both higher strength and fracture toughness for the BSS-fiber composites. A computational model was developed to simulate crack propagation in both BSS- and CSS-fiber composites, accounting for stress concentrations, interface debonding, and fiber pullout. Model predictions were validated by experimental results and will be useful in optimizing BSS-fiber morphology and other material system parameters.

Zhu, Y.T.; Valdez, J.A.; Beyerlain, I.J.; Stout, M.G.; Zhou, S.; Shi, N.; Lowe, T.C.

1999-06-29T23:59:59.000Z

191

A fuel cell overview  

SciTech Connect

This paper is an overview of the fuel cell as an efficient and environmentally benign energy conversion technology. The topics of the paper include their physical arrangement, types of fuel cells, status of commercial development, applications of the fuel cell power plants and comparison with existing alternatives, and good design practice for fuel cell safety.

Krumpelt, M. [Argonne National Lab., IL (United States); Reiser, C.

1994-10-01T23:59:59.000Z

192

Single Cell Mechanics BIOMATERIALS  

E-Print Network (OSTI)

Single Cell Mechanics BIOMATERIALS Our goal is to develop fundamental tools to measure the response of live cells to mechanical stimulation. The mechanisms by which cells convert mechanical forces evaluate the underlying mechanisms of cell mechanics. Objective Impact and Customers · Cancer, heart

193

Fuel Cell Technologies Office: Reversible Fuel Cells Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Reversible Fuel Cells Reversible Fuel Cells Workshop to someone by E-mail Share Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on Facebook Tweet about Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on Twitter Bookmark Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on Google Bookmark Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on Delicious Rank Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on Digg Find More places to share Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings Annual Merit Review Proceedings Workshop & Meeting Proceedings

194

FCT Fuel Cells: Fuel Cell R&D Activities  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cell R&D Activities to someone by E-mail Share FCT Fuel Cells: Fuel Cell R&D Activities on Facebook Tweet about FCT Fuel Cells: Fuel Cell R&D Activities on Twitter Bookmark...

195

Molten carbonate fuel cell  

DOE Patents (OSTI)

A molten electrolyte fuel cell with an array of stacked cells and cell enclosures isolating each cell except for access to gas manifolds for the supply of fuel or oxidant gas or the removal of waste gas, the cell enclosures collectively providing an enclosure for the array and effectively avoiding the problems of electrolyte migration and the previous need for compression of stack components, the fuel cell further including an inner housing about and in cooperation with the array enclosure to provide a manifold system with isolated chambers for the supply and removal of gases. An external insulated housing about the inner housing provides thermal isolation to the cell components.

Kaun, Thomas D. (New Lenox, IL); Smith, James L. (Lemont, IL)

1987-01-01T23:59:59.000Z

196

Molten carbonate fuel cell  

DOE Patents (OSTI)

A molten electrolyte fuel cell is disclosed with an array of stacked cells and cell enclosures isolating each cell except for access to gas manifolds for the supply of fuel or oxidant gas or the removal of waste gas. The cell enclosures collectively provide an enclosure for the array and effectively avoid the problems of electrolyte migration and the previous need for compression of stack components. The fuel cell further includes an inner housing about and in cooperation with the array enclosure to provide a manifold system with isolated chambers for the supply and removal of gases. An external insulated housing about the inner housing provides thermal isolation to the cell components.

Kaun, T.D.; Smith, J.L.

1986-07-08T23:59:59.000Z

197

Fuel cells seminar  

SciTech Connect

This year`s meeting highlights the fact that fuel cells for both stationary and transportation applications have reached the dawn of commercialization. Sales of stationary fuel cells have grown steadily over the past 2 years. Phosphoric acid fuel cell buses have been demonstrated in urban areas. Proton-exchange membrane fuel cells are on the verge of revolutionizing the transportation industry. These activities and many more are discussed during this seminar, which provides a forum for people from the international fuel cell community engaged in a wide spectrum of fuel cell activities. Discussions addressing R&D of fuel cell technologies, manufacturing and marketing of fuel cells, and experiences of fuel cell users took place through oral and poster presentations. For the first time, the seminar included commercial exhibits, further evidence that commercial fuel cell technology has arrived. A total of 205 papers is included in this volume.

1996-12-01T23:59:59.000Z

198

Characterization of the Bone Loss and Recovery Response at the Distal Femur Metaphysis of the Adult Male Hindlimb Unloaded Rat  

E-Print Network (OSTI)

Extended periods of mechanical unloading are known to be detrimental to bone health. Astronauts who spend months in microgravity aboard the International Space Station (ISS) are at particular risk. It is anticipated that NASA will not drastically increase the size of the astronaut corps, and this will mean increased likelihood of repeat missions for more astronauts. Thus, it is important to better understand the effects that prolonged, multiple bouts of unloading have on bone. This study utilized the hindlimb unloaded (HU) rat model to examine bone loss and recovery for single and double unloading bouts. Adult male Sprague-Dawley rats (6 months old) were randomized into the following groups: baseline (sacrificed at 6 months), 1HU7 (unloaded for 1 month, weight-bearing recovery for 3 months), 2HU10 (unloaded for 1 month, recovered for 2 months, unloaded for another month, and then recovered 2 months), 1HU10 (normal cage activity until 1 month HU ending at month 10, 2 month recovery followed), and aging controls (remained ambulatory throughout experiment). Every month (28 days), animals were terminated and the left femurs were excised, resulting in n=15 per group for each time point. Mineral and geometric properties were measured using peripheral quantitative computed tomography (pQCT) at the distal femur metaphysis, and quasi-static reduced platen compression (RPC) was used to estimate the mechanical properties of cancellous bone. Strength indices based on pQCT parameters were calculated as predictors of mechanical properties. Bone mass properties decreased due to HU and recovered within 2-3 months post-HU. A combination of increased periosteal apposition and endocortical resorption also occurred during HU. The initial HU bout suppressed normal age-related increases in mechanical properties and recovered within 1-2 months. Cancellous compressive strength index (CSI) most closely matched changes in mechanical properties. A second HU bout after two months recovery had a less detrimental effect on pQCT parameters but a greater negative impact on mechanical properties, when compared to pre-HU values. The opposite is true for mechanical properties if loss is characterized relative to aging controls. Recovery after the second HU period did not appear to be significantly affected by a previous bout of HU.

Davis, Joshua Morgan

2011-12-01T23:59:59.000Z

199

Structure of Trabecular Bone in DMP-1 Deficient Knock Out Mice ...  

Science Conference Proceedings (OSTI)

... Templates Facilitates Neural Stem Cell Adhesion, Proliferation and Differentiation ... Improving the Resistance of Ceramic Surfaces to Biofilm Formation ... Sol-Gel Synthesis of Bio-Active Nanoporous Sodium Zirconate Coated on 316L...

200

Fuel Cell Technologies Office: Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

offering cleaner, more-efficient alternatives to the combustion of gasoline and other fossil fuels. Fuel cells have the potential to replace the internal-combustion engine in...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Hydrogen & Fuel Cells - Fuel Cell - Solid Oxide  

NLE Websites -- All DOE Office Websites (Extended Search)

Electrolyzer Research and Development Solid Oxide Fuel Cells Solid oxide diagram In an SOFC, oxygen from air is reduced to ions at the cathode, which diffuse through the...

202

FCT Fuel Cells: Basics  

NLE Websites -- All DOE Office Websites (Extended Search)

Basics to someone by E-mail Basics to someone by E-mail Share FCT Fuel Cells: Basics on Facebook Tweet about FCT Fuel Cells: Basics on Twitter Bookmark FCT Fuel Cells: Basics on Google Bookmark FCT Fuel Cells: Basics on Delicious Rank FCT Fuel Cells: Basics on Digg Find More places to share FCT Fuel Cells: Basics on AddThis.com... Home Basics Current Technology DOE R&D Activities Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Technology Validation Manufacturing Codes & Standards Education Systems Analysis Contacts Basics Photo of a fuel cell stack A fuel cell uses the chemical energy of hydrogen to cleanly and efficiently produce electricity with water and heat as byproducts. (How much water?) Fuel cells are unique in terms of the variety of their potential applications; they can provide energy for systems as large as a utility

203

A tribological and biomimetic study of potential bone joint repair materials  

E-Print Network (OSTI)

This research investigates materials for bone-joint failure repair using tribological and biomimicking approaches. The materials investigated represent three different repairing strategies. Refractory metals with and without treatment are candidates for total joint replacements due to their mechanical strength, high corrosion resistance and biocompatibility. A composite of biodegradable polytrimethylene carbonate, hydroxyl apatite, and nanotubes was investigated for application as a tissue engineering scaffold. Non-biodegradable polymer polyimide combined with various concentrations of nanotubes was investigated as a cartilage replacement material. A series of experimental approaches were used in this research. These include analysis of material surfaces and debris using high-resolution techniques and tribological experiments, as well as evaluation of nanomechanical properties. Specifically, the surface structure and wear mechanisms were investigated using a scanning electron microscope and an atomic force microscope. Debris morphology and structure was investigated using a transmission electron microscope. The debris composition was analyzed using an X-ray diffractometer. Nanoindentation was incorporated to investigate the surface nanomechanical properties. Polytrimythelene carbonate combined with hydroxyapatite and nanotubes exhibited a friction coefficient lower than UHMWPE. The nanoindentation response mimicked cartilage more closely than UHMWPE. A composite formed with PI and nanotubes showed a varying friction coefficient and varying nanoindentation response with variation in nanotube concentration. Low friction coefficients corresponded with low modulus values. A theory was proposed to explain this behavior based on surface interactions between nanotubes and between nanotubes and PI. A model was developed to simulate the modulus as a function of nanotube concentration. The boronized refractory metals exhibited brittleness and cracking. Higher friction coefficients were associated with the formation of amorphous debris. The friction coefficient for boronized Cr (~0.06) under simulated body fluid conditions was in the range found in natural joints.

Ribeiro, Rahul

2006-12-01T23:59:59.000Z

204

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

November 2012 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: November 2012 on Facebook Tweet about Fuel Cell Technologies...

205

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

Newsletter Archives to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter Archives on Facebook Tweet about Fuel Cell Technologies...

206

Fuel Cell Technologies Office: Subscribe to the Fuel Cell Technologies...  

NLE Websites -- All DOE Office Websites (Extended Search)

Subscribe to the Fuel Cell Technologies Office Newsletter to someone by E-mail Share Fuel Cell Technologies Office: Subscribe to the Fuel Cell Technologies Office Newsletter on...

207

Fuel Cell Technologies Office: Fuel Cells for Portable Power...  

NLE Websites -- All DOE Office Websites (Extended Search)

for Portable Power Workshop to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cells for Portable Power Workshop on Facebook Tweet about Fuel Cell Technologies...

208

Fuel Cell Technologies Overview  

NLE Websites -- All DOE Office Websites (Extended Search)

4/3/2012 4/3/2012 eere.energy.gov Fuel Cell Technologies Overview Flow Cell Workshop Washington, DC Dr. Sunita Satyapal & Dr. Dimitrios Papageorgopoulos U.S. Department of Energy Fuel Cell Technologies Program 3/7/2011 Flow Cells for Energy Storage Workshop Purpose To understand the applied research and development needs and the grand challenges for the use of flow cells as energy-storage devices. Objectives 1. Understand the needs for applied research from stakeholders. 2. Gather input for future development of roadmaps and technical targets for flow cells for various applications. 3. Identify grand challenges and prioritize R&D needs. Flow cells combine the unique advantages of batteries and fuel cells and can offer benefits for multiple energy storage applications.

209

California Fuel Cell Partnership  

NLE Websites -- All DOE Office Websites (Extended Search)

Speaker(s): Bob Knight Date: October 19, 2000 - 12:00pm Location: Bldg. 90 The California Fuel Cell Partnership is a current collaboration among major automakers, fuel cell...

210

Photovoltaic Cell Structures  

Energy.gov (U.S. Department of Energy (DOE))

The actual structural design of a photovoltaic (PV), or solar cell, depends on the limitations of the material used in the PV cell. The four basic device designs are:

211

Crystalline Silicon Photovolatic Cells  

Energy.gov (U.S. Department of Energy (DOE))

Crystalline silicon cells are made of silicon atoms connected to one another to form a crystal lattice. This lattice comprises the solid material that forms the photovoltaic (PV) cell's...

212

Photovoltaic Cell Conversion Efficiency  

Energy.gov (U.S. Department of Energy (DOE))

The conversion efficiency of a photovoltaic (PV) cell, or solar cell, is the percentage of the solar energy shining on a PV device that is converted into electrical energy, or electricity....

213

Silicon solar cell assembly  

DOE Patents (OSTI)

A silicon solar cell assembly comprising a large, thin silicon solar cell bonded to a metal mount for use when there exists a mismatch in the thermal expansivities of the device and the mount.

Burgess, Edward L. (Albuquerque, NM); Nasby, Robert D. (Albuquerque, NM); Schueler, Donald G. (Albuquerque, NM)

1979-01-01T23:59:59.000Z

214

Photovoltaic Cell Quantum Efficiency  

Energy.gov (U.S. Department of Energy (DOE))

Quantum efficiency (QE) is the ratio of the number of charge carriers collected by a photovoltaic (PV) cell to the number of photonsor packets of lightof a given energy shining on the solar cell....

215

Energy Basics: Photovoltaic Cells  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Energy Basics Renewable Energy Printable Version Share this resource Biomass Geothermal Hydrogen Hydropower Ocean Solar Photovoltaics Cells Systems Concentrating Solar...

216

cell probe model  

Science Conference Proceedings (OSTI)

NIST. cell probe model. (definition). Definition: A model of computation where the cost of a computation is measured by the ...

2013-05-08T23:59:59.000Z

217

Electroluminescence in photovoltaic cell  

E-Print Network (OSTI)

Here we propose two methods to get electroluminescence images from photovoltaic cells in a school or home lab.

Petraglia, Antonio; 10.1088/0031-9120/46/5/F01

2011-01-01T23:59:59.000Z

218

Solar Cell Silicon  

Science Conference Proceedings (OSTI)

Jul 31, 2011 ... About this Symposium. Meeting, 2012 TMS Annual Meeting & Exhibition. Symposium, Solar Cell Silicon. Sponsorship, The Minerals, Metals...

219

Irreversible Cell Potential  

Science Conference Proceedings (OSTI)

Table 2   Cell conditions for commercial and industrial electrode processes...electrochemical machining,

220

Biomarkers of cell senescence  

DOE Patents (OSTI)

The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, .beta.-galactosidase activity is utilized as a means by which cell senescence may be assessed either in in vitro cell cultures or in vivo.

Dirmi, Goberdhan P. (Simli U.P., IN); Campisi, Judith (Berkeley, CA); Peacocke, Monica (Newton, MA)

1996-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
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221

Rapidly refuelable fuel cell  

DOE Patents (OSTI)

This invention is directed to a metal-air fuel cell where the consumable metal anode is movably positioned in the cell and an expandable enclosure, or bladder, is used to press the anode into contact with separating spacers between the cell electrodes. The bladder may be depressurized to allow replacement of the anode when consumed.

Joy, Richard W. (Santa Clara, CA)

1983-01-01T23:59:59.000Z

222

Biomarkers of cell senescence  

DOE Patents (OSTI)

The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, .beta.-galactosidase activity is utilized as a means by which cell senescence may be assessed either in vitro cell cultures or in vivo.

Dimri, Goberdhan P. (Simli U.P., IN); Campisi, Judith (Berkeley, CA); Peacocke, Monica (Newton, MA)

1998-01-01T23:59:59.000Z

223

Biomarkers of cell senescence  

DOE Patents (OSTI)

The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, {beta}-galactosidase activity is utilized as a means by which cell senescence may be assessed either in in vitro cell cultures or in vivo. 1 fig.

Dirmi, G.P.; Campisi, J.; Peacocke, M.

1996-02-13T23:59:59.000Z

224

Biomarkers of cell senescence  

DOE Patents (OSTI)

The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, {beta}-galactosidase activity is utilized as a means by which cell senescence may be assessed either in vitro cell cultures or in vivo. 1 fig.

Dimri, G.P.; Campisi, J.; Peacocke, M.

1998-08-18T23:59:59.000Z

225

NANOCOMPOSITE ENABLED SENSITIZED SOLAR CELL  

E-Print Network (OSTI)

by Dye-Sensitized Photovoltaic cells. Inorganic Chemistry,by Dye-Sensitized Photovoltaic Cells. Inorganic ChemistryThe characteristics of a photovoltaic cell. Generally,

Phuyal, Dibya

2012-01-01T23:59:59.000Z

226

Fuel Cell Technologies Office: News  

NLE Websites -- All DOE Office Websites (Extended Search)

Technologies Office: News on Twitter Bookmark Fuel Cell Technologies Office: News on Google Bookmark Fuel Cell Technologies Office: News on Delicious Rank Fuel Cell Technologies...

227

Fuel Cell Technologies Office: Webinars  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Webinars to someone by E-mail Share Fuel Cell Technologies Office: Webinars on Facebook Tweet about Fuel Cell Technologies Office: Webinars on Twitter Bookmark Fuel Cell...

228

Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies  

NLE Websites -- All DOE Office Websites (Extended Search)

Market Transformation Market Transformation Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies to someone by E-mail Share Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Facebook Tweet about Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Twitter Bookmark Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Google Bookmark Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Delicious Rank Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Digg Find More places to share Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on AddThis.com... Early Adoption of Fuel Cells Early Market Applications for Fuel Cells

229

Fuel Cell Technologies Office: DOE Fuel Cell Pre-Solicitation...  

NLE Websites -- All DOE Office Websites (Extended Search)

DOE Fuel Cell Pre-Solicitation Workshop to someone by E-mail Share Fuel Cell Technologies Office: DOE Fuel Cell Pre-Solicitation Workshop on Facebook Tweet about Fuel Cell...

230

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

2 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: January 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell...

231

Fuel Cell Technologies Office: 2010 New Fuel Cell Projects Meeting  

NLE Websites -- All DOE Office Websites (Extended Search)

2010 New Fuel Cell Projects Meeting to someone by E-mail Share Fuel Cell Technologies Office: 2010 New Fuel Cell Projects Meeting on Facebook Tweet about Fuel Cell Technologies...

232

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

3 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: January 2013 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell...

233

Fuel Cell Technologies Office: 2009 New Fuel Cell Projects Meeting  

NLE Websites -- All DOE Office Websites (Extended Search)

09 New Fuel Cell Projects Meeting to someone by E-mail Share Fuel Cell Technologies Office: 2009 New Fuel Cell Projects Meeting on Facebook Tweet about Fuel Cell Technologies...

234

Fuel Cell Technologies Office: Biogas and Fuel Cells Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Biogas and Fuel Cells Workshop to someone by E-mail Share Fuel Cell Technologies Office: Biogas and Fuel Cells Workshop on Facebook Tweet about Fuel Cell Technologies Office:...

235

Fuel Cell Technologies Office: Fuel Cells for Buildings Roadmap...  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cells for Buildings Roadmap Workshop to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cells for Buildings Roadmap Workshop on Facebook Tweet about Fuel Cell...

236

Limited Chemotherapy and Shrinking Field Radiotherapy for Osteolymphoma (Primary Bone Lymphoma): Results From the Trans-Tasman Radiation Oncology Group 99.04 and Australasian Leukaemia and Lymphoma Group LY02 Prospective Trial;Bone; Lymphoma; Radiotherapy; Chemotherapy; Clinical trial  

SciTech Connect

Purpose: To establish benchmark outcomes for combined modality treatment to be used in future prospective studies of osteolymphoma (primary bone lymphoma). Methods and Materials: In 1999, the Trans-Tasman Radiation Oncology Group (TROG) invited the Australasian Leukemia and Lymphoma Group (ALLG) to collaborate on a prospective study of limited chemotherapy and radiotherapy for osteolymphoma. The treatment was designed to maintain efficacy but limit the risk of subsequent pathological fractures. Patient assessment included both functional imaging and isotope bone scanning. Treatment included three cycles of CHOP chemotherapy and radiation to a dose of 45 Gy in 25 fractions using a shrinking field technique. Results: The trial closed because of slow accrual after 33 patients had been entered. Accrual was noted to slow down after Rituximab became readily available in Australia. After a median follow-up of 4.3 years, the five-year overall survival and local control rates are estimated at 90% and 72% respectively. Three patients had fractures at presentation that persisted after treatment, one with recurrent lymphoma. Conclusions: Relatively high rates of survival were achieved but the number of local failures suggests that the dose of radiotherapy should remain higher than it is for other types of lymphoma. Disability after treatment due to pathological fracture was not seen.

Christie, David, E-mail: david.christie@premion.com.au [Premion and Bond University, Gold Coast, Queensland (Australia); Dear, Keith [Department of Epidemiology and Population Studies, Australian National University, Canberra, New South Wales (Australia); Le, Thai [BHB, Premion, Brisbane, Queensland (Australia); Barton, Michael [Collaboration for Cancer Outcomes and Research (CCORE) and University of NSW, Sydney, New South Wales (Australia); Wirth, Andrew [Peter MacCallum Cancer Institute, Melbourne, Victoria (Australia); Porter, David [Auckland Hospital, Auckland (New Zealand); Roos, Daniel [Royal Adelaide Hospital, Adelaide, South Australia (Australia); Pratt, Gary [Royal Brisbane Hospital, Brisbane, Queensland (Australia)

2011-07-15T23:59:59.000Z

237

Fuel Cell Handbook update  

DOE Green Energy (OSTI)

The objective of this work was to update the 1988 version of DOE`s Fuel Cell Handbook. Significant developments in the various fuel cell technologies required revisions to reflect state-of-the-art configurations and performance. The theoretical presentation was refined in order to make the handbook more useful to both the casual reader and fuel cell or systems analyst. In order to further emphasize the practical application of fuel cell technologies, the system integration information was expanded. In addition, practical elements, such as suggestions and guidelines to approximate fuel cell performance, were provided.

Owens, W.R.; Hirschenhofer, J.H.; Engleman, R.R. Jr.; Stauffer, D.B.

1993-11-01T23:59:59.000Z

238

Fuel Cells Team  

NLE Websites -- All DOE Office Websites (Extended Search)

Judith Valerio at one of our 31 single-cell test stands Fuel Cell Team The FC team focus is R&D on polymer electrolyte membrane (PEM) fuel cells for commercial and military applications. Our program has had ongoing funding in the area of polymer electrolyte fuel cells since 1977 and has been responsible for enabling breakthroughs in the areas of thin film electrodes and air bleed for CO tolerance. For more information on the history of fuel cell research at Los Alamos, please click here. Fuel cells are an important enabling technology for the Hydrogen Economy and have the potential to revolutionize the way we power the nation and the world. The FC team is exploring the potential of fuel cells as energy-efficient, clean, and fuel-flexible alternatives that will

239

Graduate Program in Cancer Cell Biology CELL SHEDDING  

E-Print Network (OSTI)

Graduate Program in Cancer Cell Biology CELL SHEDDING ANOIKIS CELL SHEDDING METASTASIS NORMAL CELLS) To the Cancer Cell Biology Program: As a Graduate Student in the Cancer Cell Biology Program, I acknowledge account of my laboratory work, commit to ethics before science and devote my full and undivided time

Mohaghegh, Shahab

240

Power from the Fuel Cell  

E-Print Network (OSTI)

Power for Buildings Using Fuel-Cell Cars, Proceedings ofwell as to drive down fuel-cell system costs through productis most likely to be the fuel-cell vehicle. Fuel cells are

Lipman, Timothy E.

2000-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Fuel Cell Technologies Program Overview  

E-Print Network (OSTI)

Cell TypesFuel Cell Types Note: ITSOFC is intermediate temperature SOFC and TSOFC is tubular SOFC #12

242

Using Geodesics in Cell Cytometry  

Science Conference Proceedings (OSTI)

... Several steps are involved in going from cells to geodesics. The process starts with fluorescence microscope images of cell populations. ...

2010-09-15T23:59:59.000Z

243

Cell Dynamics and Process Control  

Science Conference Proceedings (OSTI)

ALUMINIUM REDUCTION TECHNOLOGY VII: Cell Dynamics And Process ... WITH RELEVANS TO POINT FEEDING ALUMINIUM CELL: Ove Kobbeltvedt,...

244

Fuel Cells Information at NIST  

Science Conference Proceedings (OSTI)

NIST Home > Fuel Cells Information at NIST. Fuel Cells Information at NIST. (the links below are a compilation of programs ...

2010-08-23T23:59:59.000Z

245

Comparison of the Distributions of Bromine, Lead and Zinc in Tooth and Bone from an Ancient Peruvian Burial site by X-ray Fluorescence  

SciTech Connect

Synchrotron micro X-ray fluorescence was used to study the distribution of selected trace elements (Zn, Pb, and Br) in tooth and bone samples obtained from an individual from a pre-Columbian archaeological site (Cabur) located on the north coast of Peru. The results show that Zn, Pb, and Br are present in both the teeth and bone samples and that the Zn and Pb seem to be confined to similar regions (cementum and periostium), while Br shows a novel distribution with enrichment close to the Haversian canals and (or) in regions that appear to be Ca deficient.

Martin,R.; Naftel, S.; Nelson, A.; Sapp, W.

2007-01-01T23:59:59.000Z

246

How Fuel Cells Work  

NLE Websites -- All DOE Office Websites (Extended Search)

How Fuel Cells Work How Fuel Cells Work Diagram: How a PEM fuel cell works. 1. Hydrogen fuel is channeled through field flow plates to the anode on one side of the fuel cell, while oxygen from the air is channeled to the cathode on the other side of the cell. 2. At the anode, a platinum catalyst causes the hydrogen to split into positive hydrogen ions (protons) and negatively charged electrons. 3. The Polymer Electrolyte Membrane (PEM) allows only the positively charged ions to pass through it to the cathode. The negatively charged electrons must travel along an external circuit to the cathode, creating an electrical current. 4. At the cathode, the electrons and positively charged hydrogen ions combine with oxygen to form water, which flows out of the cell.

247

Fuel Cells publications  

NLE Websites -- All DOE Office Websites (Extended Search)

Materials Science » Materials Science » Fuel Cells » Fuel Cells Publications Fuel Cells publications Research into alternative forms of energy, especially energy security, is one of the major national security imperatives of this century. Get Expertise Melissa Fox Applied Energy Email Catherine Padro Sensors & Electorchemical Devices Email Fernando Garzon Sensors & Electorchemical Devices Email Piotr Zelenay Sensors & Electorchemical Devices Email Rod Borup Sensors & Electorchemical Devices Email Karen E. Kippen Chemistry Communications Email Like a battery, a fuel cell consists of two electrodes separated by an electrolyte-in polymer electrolyte fuel cells, the separator is made of a thin polymeric membrane. Unlike a battery, a fuel cell does not need recharging-it continues to produce electricity as long as fuel flows

248

Fuel Cells Overview  

NLE Websites -- All DOE Office Websites (Extended Search)

Hydrogen Storage DELIVERY FUEL CELLS STORAGE PRODUCTION TECHNOLOGY VALIDATION CODES & STANDARDS SYSTEMS INTEGRATION / ANALYSES SAFETY EDUCATION RESEARCH & DEVELOPMENT Economy Pat Davis 2 Fuel Cells Technical Goals & Objectives Goal : Develop and demonstrate fuel cell power system technologies for transportation, stationary, and portable applications. 3 Fuel Cells Technical Goals & Objectives Objectives * Develop a 60% efficient, durable, direct hydrogen fuel cell power system for transportation at a cost of $45/kW (including hydrogen storage) by 2010. * Develop a 45% efficient reformer-based fuel cell power system for transportation operating on clean hydrocarbon or alcohol based fuel that meets emissions standards, a start-up time of 30 seconds, and a projected manufactured cost of $45/kW by

249

Distributed Energy Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Energy Fuel Cells Energy Fuel Cells DOE Hydrogen DOE Hydrogen and and Fuel Cells Fuel Cells Coordination Meeting Fuel Cell Coordination Meeting June 2-3, 2003 Electricity Users Kathi Epping Kathi Epping Objectives & Barriers Distributed Energy OBJECTIVES * Develop a distributed generation PEM fuel cell system operating on natural gas or propane that achieves 40% electrical efficiency and 40,000 hours durability at $400-750/kW by 2010. BARRIERS * Durability * Heat Utilization * Power Electronics * Start-Up Time Targets and Status Integrated Stationary PEMFC Power Systems Operating on Natural Gas or Propane Containing 6 ppm Sulfur 40,000 30,000 15,000 Hours Durability 750 1,250 2,500 $/kWe Cost 40 32 30 % Electrical Efficiency Large (50-250 kW) Systems 40,000 30,000 >6,000 Hours Durability 1,000 1,500 3,000

250

Concentrator silicon cell research  

Science Conference Proceedings (OSTI)

This project continued the developments of high-efficiency silicon concentrator solar cells with the goal of achieving a cell efficiency in the 26 to 27 percent range at a concentration level of 150 suns of greater. The target efficiency was achieved with the new PERL (passivated emitter, rear locally diffused) cell structure, but only at low concentration levels around 20 suns. The PERL structure combines oxide passivation of both top and rear surfaces of the cells with small area contact to heavily doped regions on the top and rear surfaces. Efficiency in the 22 to 23 percent range was also demonstrated for large-area concentrator cells fabricated with the buried contact solar cell processing sequence, either when combined with prismatic covers or with other innovative approaches to reduce top contact shadowing. 19 refs.

Green, M.A.; Wenham, S.R.; Zhang, F.; Zhao, J.; Wang, A. [New South Wales Univ., Kensington (Australia). Solar Photovoltaic Lab.

1992-04-01T23:59:59.000Z

251

Amorphous silicon solar cells  

SciTech Connect

The fabrication, performance, and applications of a-Si solar cells are discussed, summarizing the results of recent experimental investigations and trial installations. Topics examined include the fundamental principles and design strategies of solar power installations; the characteristics of monocrystalline-Si solar cells; techniques for reducing the cost of solar cells; independent, linked, and hybrid solar power systems; proposed satellite solar power systems; and the use of solar cells in consumer appliances. Consideration is given to the history of a-Si, a-Si fabrication techniques, quality criteria for a-Si films, solar cells based on a-Si, and techniques for increasing the efficiency and lowering the cost of a-Si solar cells. Graphs, diagrams, drawings, and black-and-white and color photographs are provided. 136 references.

Takahashi, K.; Konagai, M.

1986-01-01T23:59:59.000Z

252

Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Flow Cells for Energy Flow Cells for Energy Storage Workshop to someone by E-mail Share Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on Facebook Tweet about Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on Twitter Bookmark Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on Google Bookmark Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on Delicious Rank Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on Digg Find More places to share Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings Annual Merit Review Proceedings

253

Fuel Cell Technologies Office: Early Market Applications for Fuel Cell  

NLE Websites -- All DOE Office Websites (Extended Search)

Market Transformation Market Transformation Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies to someone by E-mail Share Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Facebook Tweet about Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Twitter Bookmark Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Google Bookmark Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Delicious Rank Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Digg Find More places to share Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on AddThis.com...

254

Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Joint Fuel Cell Bus Joint Fuel Cell Bus Workshop to someone by E-mail Share Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on Facebook Tweet about Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on Twitter Bookmark Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on Google Bookmark Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on Delicious Rank Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on Digg Find More places to share Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings Annual Merit Review Proceedings Workshop & Meeting Proceedings Webinars

255

Heterojunction solar cell  

DOE Patents (OSTI)

A high-efficiency single heterojunction solar cell is described wherein a thin emitter layer (preferably Ga[sub 0.52]In[sub 0.48]P) forms a heterojunction with a GaAs absorber layer. The conversion efficiency of the solar cell is at least 25.7%. The solar cell preferably includes a passivating layer between the substrate and the absorber layer. An anti-reflection coating is preferably disposed over the emitter layer. 1 fig.

Olson, J.M.

1994-08-30T23:59:59.000Z

256

Heterojunction solar cell  

DOE Patents (OSTI)

A high-efficiency single heterojunction solar cell wherein a thin emitter layer (preferably Ga.sub.0.52 In.sub.0.48 P) forms a heterojunction with a GaAs absorber layer. The conversion effiency of the solar cell is at least 25.7%. The solar cell preferably includes a passivating layer between the substrate and the absorber layer. An anti-reflection coating is preferably disposed over the emitter layer.

Olson, Jerry M. (Lakewood, CO)

1994-01-01T23:59:59.000Z

257

Heterojunction solar cells  

DOE Green Energy (OSTI)

A qualitative description of semiconductor/semiconductor heterojunction solar cells is given. The two groups of heterojunctions of greatest economic potential, very highly efficient cells for concentrator applications and moderately efficient thin film cells for flat plates, are described with examples. These examples illustrate the role of heterojunctions in surface passivation, monolithic multijunction devices, devices with semiconductors of only one conductivity type, and low-temperature fabrication techniques.

Wagner, S.

1978-01-01T23:59:59.000Z

258

Molten salt lithium cells  

DOE Patents (OSTI)

Lithium-based cells are promising for applications such as electric vehicles and load-leveling for power plants since lithium is very electropositive and light weight. One type of lithium-based cell utilizes a molten salt electrolyte and is operated in the temperature range of about 400 to 500/sup 0/C. Such high temperature operation accelerates corrosion problems and a substantial amount of energy is lost through heat transfer. The present invention provides an electrochemical cell which may be operated at temperatures between about 100 to 170/sup 0/C. The cell is comprised of an electrolyte, which preferably includes lithium nitrate, and a lithium or lithium alloy electrode.

Raistrick, I.D.; Poris, J.; Huggins, R.A.

1980-07-18T23:59:59.000Z

259

Cell Design and Performance  

Science Conference Proceedings (OSTI)

Mar 4, 2013 ... In Depth Analysis of Energy-Saving and Current Efficiency Improvement of Aluminum Reduction Cells: Jianfei Zhou1; Marc Dupuis2; Feiya...

260

Test Cell Location  

NLE Websites -- All DOE Office Websites (Extended Search)

2012 Fiat 500 Test Cell Location 2WD Vehicle Setup Information Downloadable Dynamometer Database (D 3 )- Test Summary Sheet Vehicle Architecture Conventional Vehicle Dynamometer...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Test Cell Location  

NLE Websites -- All DOE Office Websites (Extended Search)

2013 Nissan Altima Test Cell Location 2WD Vehicle Setup Information Downloadable Dynamometer Database (D 3 )- Test Summary Sheet Vehicle Architecture Conventional Vehicle...

262

Aluminum Smelter Cell Dynamics  

Science Conference Proceedings (OSTI)

He has become an acclaimed world leader in cell diagnostics and operations as well as being a regular contributor to TMS Light Metals. He teaches in the TMS...

263

Solar Cell Silicon  

Science Conference Proceedings (OSTI)

... continued and costs have been cut dramatically along the production value chain. The most important feedstock for crystalline solar cells is high purity silicon .

264

Modeling & Simulation - Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

GCTool Computer Model Helps Focus Fuel Cell Vehicle Research Somewhere near Detroit, an automotive engineer stares at the ceiling, wondering how to squeeze 1% more efficiency out...

265

Ceramic Fuel Cells (SOFC)  

NLE Websites -- All DOE Office Websites (Extended Search)

in hot box included Anode Electrolyte Key cost drivers identified for tubular designs * Cell * Current Collectors * Seals BOP in hot box: * Insulation (thermal) * Recuperator *...

266

Molten salt lithium cells  

DOE Patents (OSTI)

Lithium-based cells are promising for applications such as electric vehicles and load-leveling for power plants since lithium is very electropositive and light weight. One type of lithium-based cell utilizes a molten salt electrolyte and is operated in the temperature range of about 400.degree.-500.degree. C. Such high temperature operation accelerates corrosion problems and a substantial amount of energy is lost through heat transfer. The present invention provides an electrochemical cell (10) which may be operated at temperatures between about 100.degree.-170.degree. C. Cell (10) comprises an electrolyte (16), which preferably includes lithium nitrate, and a lithium or lithium alloy electrode (12).

Raistrick, Ian D. (Menlo Park, CA); Poris, Jaime (Portola Valley, CA); Huggins, Robert A. (Stanford, CA)

1983-01-01T23:59:59.000Z

267

Molten salt lithium cells  

DOE Patents (OSTI)

Lithium-based cells are promising for applications such as electric vehicles and load-leveling for power plants since lithium is very electropositive and light weight. One type of lithium-based cell utilizes a molten salt electrolyte and is operated in the temperature range of about 400.degree.-500.degree. C. Such high temperature operation accelerates corrosion problems and a substantial amount of energy is lost through heat transfer. The present invention provides an electrochemical cell (10) which may be operated at temperatures between about 100.degree.-170.degree. C. Cell (10) comprises an electrolyte (16), which preferably includes lithium nitrate, and a lithium or lithium alloy electrode (12).

Raistrick, Ian D. (Menlo Park, CA); Poris, Jaime (Portola Valley, CA); Huggins, Robert A. (Stanford, CA)

1982-02-09T23:59:59.000Z

268

Opportunities with Fuel Cells  

Reports and Publications (EIA)

The concept for fuel cells was discovered in the nineteenth century. Today, units incorporating this technology are becoming commercially available for cogeneration applications.

Information Center

1994-05-01T23:59:59.000Z

269

Hydrogen Fuel Cells  

Fuel Cell Technologies Publication and Product Library (EERE)

The fuel cell an energy conversion device that can efficiently capture and use the power of hydrogen is the key to making it happen.

270

Test Cell Location  

NLE Websites -- All DOE Office Websites (Extended Search)

Focus Test Cell Location 2WD Vehicle Setup Information Downloadable Dynamometer Database (D 3 )- Test Summary Sheet Vehicle Architecture Conventional Vehicle Dynamometer Input...

271

Test Cell Location  

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Chrysler 300 Test Cell Location 2WD Vehicle Setup Information Downloadable Dynamometer Database (D 3 )- Test Summary Sheet Vehicle Architecture Conventional Vehicle Dynamometer...

272

Test Cell Location  

NLE Websites -- All DOE Office Websites (Extended Search)

Mazda 3 i-Stop Test Cell Location APRF- 4WD Vehicle Setup Information Downloadable Dynamometer Database (D 3 )- Test Summary Sheet Vehicle Architecture Conventional- Start Stop...

273

Micro fuel cell  

SciTech Connect

An ambient temperature, liquid feed, direct methanol fuel cell device is under development. A metal barrier layer was used to block methanol crossover from the anode to the cathode side while still allowing for the transport of protons from the anode to the cathode. A direct methanol fuel cell (DMFC) is an electrochemical engine that converts chemical energy into clean electrical power by the direct oxidation of methanol at the fuel cell anode. This direct use of a liquid fuel eliminates the need for a reformer to convert the fuel to hydrogen before it is fed into the fuel cell.

Zook, L.A.; Vanderborgh, N.E. [Los Alamos National Lab., NM (United States); Hockaday, R. [Energy Related Devices Inc., Los Alamos, NM (United States)

1998-12-31T23:59:59.000Z

274

Fuel Cell Demonstration Program  

DOE Green Energy (OSTI)

In an effort to promote clean energy projects and aid in the commercialization of new fuel cell technologies the Long Island Power Authority (LIPA) initiated a Fuel Cell Demonstration Program in 1999 with six month deployments of Proton Exchange Membrane (PEM) non-commercial Beta model systems at partnering sites throughout Long Island. These projects facilitated significant developments in the technology, providing operating experience that allowed the manufacturer to produce fuel cells that were half the size of the Beta units and suitable for outdoor installations. In 2001, LIPA embarked on a large-scale effort to identify and develop measures that could improve the reliability and performance of future fuel cell technologies for electric utility applications and the concept to establish a fuel cell farm (Farm) of 75 units was developed. By the end of October of 2001, 75 Lorax 2.0 fuel cells had been installed at the West Babylon substation on Long Island, making it the first fuel cell demonstration of its kind and size anywhere in the world at the time. Designed to help LIPA study the feasibility of using fuel cells to operate in parallel with LIPA's electric grid system, the Farm operated 120 fuel cells over its lifetime of over 3 years including 3 generations of Plug Power fuel cells (Lorax 2.0, Lorax 3.0, Lorax 4.5). Of these 120 fuel cells, 20 Lorax 3.0 units operated under this Award from June 2002 to September 2004. In parallel with the operation of the Farm, LIPA recruited government and commercial/industrial customers to demonstrate fuel cells as on-site distributed generation. From December 2002 to February 2005, 17 fuel cells were tested and monitored at various customer sites throughout Long Island. The 37 fuel cells operated under this Award produced a total of 712,635 kWh. As fuel cell technology became more mature, performance improvements included a 1% increase in system efficiency. Including equipment, design, fuel, maintenance, installation, and decommissioning the total project budget was approximately $3.7 million.

Gerald Brun

2006-09-15T23:59:59.000Z

275

Cell Stem Cell, Volume 12 Supplemental Information  

E-Print Network (OSTI)

E. Jacobsen, Matteo Pellegrini and Amander T. Clark #12;Figure S1. DNA Methylation in PGCs and iPGCs somatic cells from e10.5 embryos (D) and iPGCs (E). The xaxis denotes individual CpG dinucleotides of differentiation, showing gating strategy for SSEA1+/cKitbright iPGCs (green). G: Metaplot of methylation

Jacobsen, Steve

276

Metal halogen electrochemical cell  

DOE Patents (OSTI)

It has now been discovered that reduction in the coulombic efficiency of metal halogen cells can be minimized if the microporous separator employed in such cells is selected from one which is preferably wet by the aqueous electrolyte and is not wet substantially by the cathodic halogen.

Bellows, Richard J. (Hampton, NJ); Kantner, Edward (E. Brunswick, NJ)

1988-08-23T23:59:59.000Z

277

Hydrogen Fuel Cell Engines  

E-Print Network (OSTI)

the batteries, and to power accessories like the air condi- tioner and heater. Hybrid electric cars can exceed#12;#12;Hydrogen Fuel Cell Engines MODULE 8: FUEL CELL HYBRID ELECTRIC VEHICLES CONTENTS 8.1 HYBRID ELECTRIC VEHICLES .................................................................................. 8-1 8

278

Hydrogen Fuel Cell Engines  

E-Print Network (OSTI)

#12;#12;Hydrogen Fuel Cell Engines MODULE 11:GLOSSARY AND CONVERSIONS CONTENTS 11.1 GLOSSARY Cell Engines MODULE 11:GLOSSARY AND CONVERSIONS OBJECTIVES This module is for reference only. Hydrogen MODULE 11: GLOSSARY AND CONVERSIONS PAGE 11-1 11.1 Glossary This glossary covers words, phrases

279

Molecular Cell Short Article  

E-Print Network (OSTI)

Molecular Cell Short Article Nucleosome Organization Affects the Sensitivity of Gene Expression to Promoter Mutations Gil Hornung,1 Moshe Oren,2 and Naama Barkai1,* 1Department of Molecular Genetics 2Department of Molecular Cell Biology Weizmann Institute of Science, Rehovot, Israel *Correspondence: naama

Barkai, Naama

280

Fuel cell market applications  

DOE Green Energy (OSTI)

This is a review of the US (and international) fuel cell development for the stationary power generation market. Besides DOE, GRI, and EPRI sponsorship, the US fuel cell program has over 40% cost-sharing from the private sector. Support is provided by user groups with over 75 utility and other end-user members. Objectives are to develop and demonstrate cost-effective fuel cell power generation which can initially be commercialized into various market applications using natural gas fuel by the year 2000. Types of fuel cells being developed include PAFC (phosphoric acid), MCFC (molten carbonate), and SOFC (solid oxide); status of each is reported. Potential international applications are reviewed also. Fuel cells are viewed as a force in dispersed power generation, distributed power, cogeneration, and deregulated industry. Specific fuel cell attributes are discussed: Fuel cells promise to be one of the most reliable power sources; they are now being used in critical uninterruptible power systems. They need hydrogen which can be generated internally from natural gas, coal gas, methanol landfill gas, or other fuels containing hydrocarbons. Finally, fuel cell development and market applications in Japan are reviewed briefly.

Williams, M.C.

1995-12-31T23:59:59.000Z

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281

Fuel cell generator  

DOE Patents (OSTI)

High temperature solid oxide electrolyte fuel cell generators which allow controlled leakage among plural chambers in a sealed housing. Depleted oxidant and fuel are directly reacted in one chamber to combust remaining fuel and preheat incoming reactants. The cells are preferably electrically arranged in a series-parallel configuration.

Isenberg, Arnold O. (Forest Hills, PA)

1983-01-01T23:59:59.000Z

282

NREL: Learning - Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cells Fuel Cells Fuel cells and their ability to cleanly produce electricity from hydrogen and oxygen are what make hydrogen attractive as a "fuel" for transportation use particularly, but also as a general energy carrier for homes and other uses, and for storing and transporting otherwise intermittent renewable energy. Fuel cells function somewhat like a battery-with external fuel being supplied rather than stored electricity-to generate power by chemical reaction rather than combustion. Hydrogen fuel cells, for instance, feed hydrogen gas into an electrode that contains a catalyst, such as platinum, which helps to break up the hydrogen molecules into positively charged hydrogen ions and negatively charged electrons. The electrons flow from the electrode to a terminal that

283

NETL: Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cells Fuel Cells Coal and Power Systems Fuel Cells SECA Logo Welcome to NETL's Fuel Cells Webpage. In partnership with private industry, educational institutions and national laboratories, we are leading the research, development, and demonstration of high efficiency, fuel flexible solid oxide fuel cells (SOFCs) and coal-based SOFC power generation systems for stationary market large central power plants under the Solid State Energy Conversion Alliance (SECA). The SECA cost reduction goal is to have SOFC systems capable of being manufactured at $400 per kilowatt by 2010. Concurrently, the scale-up, aggregation, and integration of the technology will progress in parallel leading to prototype validation of megawatt (MW)-class fuel flexible products by 2012 and 2015. The SECA coal-based systems goal is the development of large

284

Fuel Cell Development Status  

NLE Websites -- All DOE Office Websites (Extended Search)

Development Status Michael Short Systems Engineering Manager United Technologies Corporation Research Center Hamilton Sundstrand UTC Power UTC Fire & Security Fortune 50 corporation $52.9B in annual sales in 2009 ~60% of Sales are in building technologies Transportation Stationary Fuel Cells Space & Defense * Fuel cell technology leader since 1958 * ~ 550 employees * 768+ Active U.S. patents, more than 300 additional U.S. patents pending * Global leader in efficient, reliable, and sustainable fuel cell solutions UTC Power About Us PureCell ® Model 400 Solution Process Overview Power Conditioner Converts DC power to high-quality AC power 3 Fuel Cell Stack Generates DC power from hydrogen and air 2 Fuel Processor Converts natural gas fuel to hydrogen

285

Fuel Cell 101  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cell 101 Fuel Cell 101 Don Hoffman Don Hoffman Ship Systems & Engineering Research Division March 2011 Distribution Statement A: Approved for public release; distribution is unlimited. Fuel Cell Operation * A Fuel Cell is an electrochemical power source * It supplies electricity by combining hydrogen and oxygen electrochemically without combustion. * It is configured like a battery with anode and cathode. * Unlike a battery, it does not run down or require recharging and will produce electricity and will produce electricity, heat and water as long as fuel is supplied. 2H + + 2e - O 2 + 2H + + 2e - 2H 2 O H 2 Distribution Statement A: Approved for public release; distribution is unlimited. 2 FUEL FUEL CONTROLS Fuel Cell System HEAT & WATER CLEAN CLEAN EXHAUST EXHAUST

286

Physics of adherent cells  

E-Print Network (OSTI)

One of the most unique physical features of cell adhesion to external surfaces is the active generation of mechanical force at the cell-material interface. This includes pulling forces generated by contractile polymer bundles and networks, and pushing forces generated by the polymerization of polymer networks. These forces are transmitted to the substrate mainly by focal adhesions, which are large, yet highly dynamic adhesion clusters. Tissue cells use these forces to sense the physical properties of their environment and to communicate with each other. The effect of forces is intricately linked to the material properties of cells and their physical environment. Here a review is given of recent progress in our understanding of the role of forces in cell adhesion from the viewpoint of theoretical soft matter physics and in close relation to the relevant experiments.

Schwarz, Ulrich S

2013-01-01T23:59:59.000Z

287

Quality of Life After Palliative Radiation Therapy for Patients With Painful Bone Metastases: Results of an International Study Validating the EORTC QLQ-BM22  

SciTech Connect

Purpose: Radiation therapy (RT) is an effective method of palliating painful bone metastases and can improve function and reduce analgesic requirements. In advanced cancer patients, quality of life (QOL) is the primary outcome of interest over traditional endpoints such as survival. The purpose of our study was to compare bone metastasis-specific QOL scores among patients who responded differently to palliative RT. Methods and Materials: Patients receiving RT for bone metastases across 6 countries were prospectively enrolled from March 2010-January 2011 in a trial validating the QLQ-BM22 and completed the QLQ-BM22 and the core measure (QLQ-C30) at baseline and after 1 month. Pain scores and analgesic intake were recorded, and response to RT was determined according to the latest published guidelines. The Kruskal-Wallis nonparametric and Wilcoxon rank sum tests compared changes in QOL among response groups. A Bonferroni-adjusted P<.003 indicated statistical significance. Results: Of 79 patients who received palliative RT, 59 were assessable. Partial response, pain progression, and indeterminate response were observed in 22, 8, and 29 patients, respectively; there were no patients with a complete response. Patients across all groups had similar baseline QOL scores apart from physical functioning (patients who progressed had better initial functioning). One month after RT, patients who responded had significant improvements in 3 of 4 QLQ-BM22 domains (painful site, P<.0001; painful characteristic, P<.0001; and functional interference, P<.0001) and 3 QLQ-C30 domains (physical functioning, P=.0006; role functioning, P=.0026; and pain, P<.0001). Patients with progression in pain had significantly worse functional interference (P=.0007) and pain (P=.0019). Conclusions: Patients who report pain relief after palliative RT also have better QOL with respect to bone metastasis-specific issues. The QLQ-BM22 and QLQ-C30 are able to discriminate among patients with varying responses and are recommended for use in future bone metastasis clinical trials.

Zeng Liang [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada); Chow, Edward, E-mail: edward.chow@sunnybrook.ca [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada); Bedard, Gillian; Zhang, Liying [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada); Fairchild, Alysa [Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada)] [Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada); Vassiliou, Vassilios [Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia (Cyprus)] [Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia (Cyprus); Alm El-Din, Mohamed A. [Department of Clinical Oncology, Tanta University Hospital, Tanta Faculty of Medicine, Tanta (Egypt)] [Department of Clinical Oncology, Tanta University Hospital, Tanta Faculty of Medicine, Tanta (Egypt); Jesus-Garcia, Reynaldo [Department of Orthopedic Oncology, Federal University of Sao Paulo, Sao Paulo (Brazil)] [Department of Orthopedic Oncology, Federal University of Sao Paulo, Sao Paulo (Brazil); Kumar, Aswin [Division of Gynaecology and Genitourinary Oncology, Department of Radiation Oncology, Regional Cancer Center, Trivandrum (India)] [Division of Gynaecology and Genitourinary Oncology, Department of Radiation Oncology, Regional Cancer Center, Trivandrum (India); Forges, Fabien [Inserm CIE3, Saint Etienne University Hospital, Saint-Etienne (France) [Inserm CIE3, Saint Etienne University Hospital, Saint-Etienne (France); Unit of Clinical Research, Innovation, and Pharmacology, Saint Etienne University Hospital, Saint-Etienne (France); Tseng, Ling-Ming [Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan (China)] [Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan (China); Hou, Ming-Feng [Department of Gastroenterologic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan (China)] [Department of Gastroenterologic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan (China); Chie, Wei-Chu [Department of Public Health and Institute of Epidemiology and Preventative Medicine, National Taiwan University, Taipei, Taiwan (China)] [Department of Public Health and Institute of Epidemiology and Preventative Medicine, National Taiwan University, Taipei, Taiwan (China); Bottomley, Andrew [European Organisation for Research and Treatment of Cancer, EORTC Headquarters, Brussels (Belgium)] [European Organisation for Research and Treatment of Cancer, EORTC Headquarters, Brussels (Belgium)

2012-11-01T23:59:59.000Z

288

Solid oxide fuel cell generator  

DOE Patents (OSTI)

A solid oxide fuel cell generator has a plenum containing at least two rows of spaced apart, annular, axially elongated fuel cells. An electrical conductor extending between adjacent rows of fuel cells connects the fuel cells of one row in parallel with each other and in series with the fuel cells of the adjacent row. 5 figures.

Di Croce, A.M.; Draper, R.

1993-11-02T23:59:59.000Z

289

Solid oxide fuel cell generator  

DOE Patents (OSTI)

A solid oxide fuel cell generator has a plenum containing at least two rows of spaced apart, annular, axially elongated fuel cells. An electrical conductor extending between adjacent rows of fuel cells connects the fuel cells of one row in parallel with each other and in series with the fuel cells of the adjacent row.

Di Croce, A. Michael (Murrysville, PA); Draper, Robert (Churchill Boro, PA)

1993-11-02T23:59:59.000Z

290

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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2 to someone by E-mail 2 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Archives Subscribe

291

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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3 to someone by E-mail 3 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter

292

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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September 2012 to someone by E-mail September 2012 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications

293

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

fuel cell devices to charge electronics such as cell phones and audio players. EERE funding for hydrogen and fuel cells has led to more than 450 patents, 60 commercial...

294

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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2 to someone by E-mail 2 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Archives Subscribe Program Presentations

295

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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August 2013 to someone by E-mail August 2013 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter

296

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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October 2012 to someone by E-mail October 2012 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications

297

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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April 2012 to someone by E-mail April 2012 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Archives

298

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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3 to someone by E-mail 3 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Archives Subscribe Program Presentations

299

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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2 to someone by E-mail 2 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Archives Subscribe

300

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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September/October 2013 to someone by E-mail September/October 2013 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on AddThis.com... Publications

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
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301

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

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August 2012 to someone by E-mail August 2012 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter

302

Fuel Cell Technologies Office: Hydrogen and Fuel Cell Manufacturing...  

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Hydrogen and Fuel Cell Manufacturing R&D Workshop to someone by E-mail Share Fuel Cell Technologies Office: Hydrogen and Fuel Cell Manufacturing R&D Workshop on Facebook Tweet...

303

Cochlear hair cell regeneration from neonatal mouse supporting cells  

E-Print Network (OSTI)

Unlike lower vertebrates, capable of spontaneous hair cell regeneration, mammals experience permanent sensorineural hearing loss following hair cell damage. Although low levels of hair cell regeneration have been demonstrated ...

Bramhall, Naomi F

2012-01-01T23:59:59.000Z

304

Fuel Cell Technologies Office: DOE Hydrogen and Fuel Cells Coordinatio...  

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DOE Hydrogen and Fuel Cells Coordination Meeting to someone by E-mail Share Fuel Cell Technologies Office: DOE Hydrogen and Fuel Cells Coordination Meeting on Facebook Tweet about...

305

Fuel Cells Vehicle Systems Analysis (Fuel Cell Freeze Investigation)  

DOE Green Energy (OSTI)

Presentation on Fuel Cells Vehicle Systems Analysis (Fuel Cell Freeze Investigation) for the 2005 Hydrogen, Fuel Cells & Infrastructure Technologies Program Annual Review held in Arlington, Virginia on May 23-26, 2005.

Pesaran, A.; Kim, G.; Markel, T.; Wipke, K.

2005-05-01T23:59:59.000Z

306

Ellipsoidal cell flow system  

SciTech Connect

The disclosure relates to a system incorporating an ellipsoidal flow chamber having light reflective walls for low level light detection in practicing cellular analysis. The system increases signal-to-noise ratio by a factor of ten over prior art systems. In operation, laser light passes through the primary focus of the ellipsoid. A controlled flow of cells simultaneously passes through this focus so that the laser light impinges on the cells and is modulated by the cells. The reflective walls of the ellipsoid reflect the cell-modulated light to the secondary focus of the ellipsoid. A tapered light guide at the secondary focus picks up a substantial portion of modulated reflective light and directs it onto a light detector to produce a signal. The signal is processed to obtain the intensity distribution of the modulated light and hence sought after characteristics of the cells. In addition, cells may be dyed so as to fluoresce in response to the laser light and their fluorescence may be processed as cell-modulated light above described. A light discriminating filter would be used to distinguish reflected modulated laser light from reflected fluorescent light.

Salzman, Gary C. (Los Alamos, NM); Mullaney, Paul F. (Los Alamos, NM)

1976-01-01T23:59:59.000Z

307

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

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Technologies and Products Supported by the Fuel Cell Technologies Office, finds DOE funding has led to more than 360 hydrogen and fuel cell patents, 36 commercial...

308

NREL: Hydrogen and Fuel Cells Research - Fuel Cell System Contaminants...  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cell System Contaminants Material Screening Data NREL designed this interactive material selector tool to help fuel cell developers and material suppliers explore the results...

309

Fuel Cell Technologies Office: Reversible Fuel Cells Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

of Reversible Fuel Cell Systems at Proton Energy, Mr. Everett Anderson, PROTON ON SITE Regenerative Fuel Cells for Energy Storage, Mr. Corky Mittelsteadt, Giner Electrochemical...

310

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

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Information Resources Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter to someone by E-mail Share Fuel...

311

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

Research, Development and Demonstration Plan* to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Multi-Year Research, Development and...

312

Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologie...  

NLE Websites -- All DOE Office Websites (Extended Search)

Adoption of Fuel Cell Technologies Federal Facilities Guide Read Procuring Fuel Cells for Stationary Power: A Guide for Federal Facility Decision Makers for step-by-step guidance...

313

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

Energy Efficiency and Renewable Energy EERE Home | Programs & Offices | Consumer Information Fuel Cell Technologies Office Search Search Help Fuel Cell Technologies Office HOME...

314

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

offices, including Fuel Cell Technologies. Funding Opportunities SBIRSTTR Phase I Release 1 Technical Topics Announced for FY14-Hydrogen and Fuel Cell Topics Include...

315

Low proliferation and high apoptosis of osteoblastic cells on hydrophobic surface are associated with defective Ras signaling  

Science Conference Proceedings (OSTI)

The hydrophobic (HPB) nature of most polymeric biomaterials has been a major obstacle in using those materials in vivo due to low compatibility with cells. However, there is little knowledge of the molecular detail to explain how surface hydrophobicity affects cell responses. In this study, we compared the proliferation and apoptosis of human osteoblastic MG63 cells adhered to hydrophilic (HPL) and hydrophobic surfaces. On the hydrophobic surface, less formation of focal contacts and actin stress fibers, a delay in cell cycle progression, and an increase in apoptosis were observed. By using fibroblast growth factor 1 (FGF1) as a model growth factor, we also investigated intracellular signaling pathways on hydrophilic and hydrophobic surfaces. The activation of Ras, Akt, and ERK by FGF1 was impaired in MG63 cells on the hydrophobic surface. The overexpression of constitutively active form of Ras and Akt rescued those cells from apoptosis and recovered cell cycle progression. Furthermore, their overexpression also restored the actin cytoskeletal organization on the hydrophobic surface. Finally, the proliferative, antiapoptotic, and cytoskeletal effects of constitutively active Ras in MG63 cells on the hydrophobic surface were blocked by wortmannin and PD98059 that inhibit Akt and ERK activation, respectively. Therefore, our results suggest that the activation of Ras and its downstream molecules Akt and ERK to an appropriate level is one of crucial elements in the determination of osteoblast cell responses. The Ras pathway may represent a cell biological target that should be considered for successful surface modification of biomaterials to induce adequate cell responses in the bone tissue.

Chang, Eun-Ju [Laboratory for the Study of Molecular Biointerfaces, Department of CMF Cell and Developmental Biology, College of Dentistry and DRI, and Intellectual Biointerface Engineering Center, Seoul National University, Seoul 110-749 (Korea, Republic of); Kim, Hong-Hee [Laboratory for the Study of Molecular Biointerfaces, Department of CMF Cell and Developmental Biology, College of Dentistry and DRI, and Intellectual Biointerface Engineering Center, Seoul National University, Seoul 110-749 (Korea, Republic of); Huh, Jung-Eun [Laboratory for the Study of Molecular Biointerfaces, Department of CMF Cell and Developmental Biology, College of Dentistry and DRI, and Intellectual Biointerface Engineering Center, Seoul National University, Seoul 110-749 (Korea, Republic of); Kim, In-Ae [Laboratory for the Study of Molecular Biointerfaces, Department of CMF Cell and Developmental Biology, College of Dentistry and DRI, and Intellectual Biointerface Engineering Center, Seoul National University, Seoul 110-749 (Korea, Republic of); Seung Ko, Jea [Laboratory for the Study of Molecular Biointerfaces, Department of CMF Cell and Developmental Biology, College of Dentistry and DRI, and Intellectual Biointerface Engineering Center, Seoul National University, Seoul 110-749 (Korea, Republic of); Chung, Chong-Pyoung [Department of Periodontology, College of Dentistry and Intellectual Biointerface Engineering Center, Seoul National University, Seoul 110-749 (Korea, Republic of); Kim, Hyun-Man [Laboratory for the Study of Molecular Biointerfaces, Department of CMF Cell and Developmental Biology, College of Dentistry and DRI, and Intellectual Biointerface Engineering Center, Seoul National University, Seoul 110-749 (Korea, Republic of)]. E-mail: hyunmkim@plaza.snu.ac.kr

2005-02-01T23:59:59.000Z

316

Lateral superlattice solar cells  

DOE Green Energy (OSTI)

A novel structure which comprises of a lateral superlattice as the active layer of a solar cell is proposed. If the alternating regions A and B of a lateral superlattice ABABAB... are chosen to have a Type-II band offset, it is shown that the performance of the active absorbing region of the solar cell is optimized. In essence, the Type-II lateral superlattice region can satisfy the material requirements for an ideal solar cells active absorbing region, i.e. simultaneously having a very high transition probability for photogeneration and a very long minority carrier recombination lifetime.

Mascarenhas, A.; Zhang, Y. [National Renewable Energy Lab., Golden, CO (United States); Millunchick, J.M.; Twesten, R.D.; Jones, E.D. [Sandia National Labs., Albuquerque, NM (United States)

1997-10-01T23:59:59.000Z

317

Battery cell soldering apparatus  

SciTech Connect

A battery cell soldering apparatus for coupling a plurality of battery cells within a battery casing comprises a support platform and a battery casing holder. The support platform operatively supports a soldering block including a plurality of soldering elements coupled to an electrical source together with a cooling means and control panel to control selectively the heating and cooling of the soldering block when the battery cells within the battery casing are held inverted in operative engagement with the plurality of soldering elements by the battery casing holder.

Alvarez, O.E.

1979-09-25T23:59:59.000Z

318

PLUTONIUM ELECTROREFINING CELLS  

DOE Patents (OSTI)

Electrorefining cells for obtaining 99.98% plutonium are described. The cells consist of an impure liquid plutonium anode, a molten PuCl/sub 3/-- alkali or alkaline earth metal chloanode, a molten PuCl/sub 3/-alkali or alkaline earth metal chloride electrolyte, and a nonreactive cathode, all being contained in nonreactive ceramic containers which separate anode from cathode by a short distance and define a gap for the collection of the purified liquid plutonium deposited on the cathode. Important features of these cells are the addition of stirrer blades on the anode lead and a large cathode surface to insure a low current density. (AEC)

Mullins, L.J. Jr.; Leary, J.A.; Bjorklund, C.W.; Maraman, W.J.

1963-07-16T23:59:59.000Z

319

Fuel Cells & Renewable Portfolio Standards  

E-Print Network (OSTI)

.....................................................12 SOFC Battery Range Extender Auxiliary Power Unit (SOFC) as Military APU Replacements" (presentation, DOD-DOE Workshop on Fuel Cells in Aviation cell plasma lighting demonstration, a solid oxide fuel cell (SOFC) battery range extender APU

320

Energy Basics: Photovoltaic Cell Structures  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

the middle, is Eg2; and Cell 3, at the bottom, is Eg3. The top cell captures the high-energy photons and passes the rest of the photons on to be absorbed by lower-bandgap cells. A...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
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321

RECHARGEABLE MOLTEN-SALT CELLS  

E-Print Network (OSTI)

KC! /FeS 2 cell lithium-silicon magnesium oxide molten-saltmolten-salt cells Na/Na glass/Na:z.Sn-S cell Na/NazOxA!Symposium on Molten Salts, Physical Electrochemistry

Cairns, Elton J.

2013-01-01T23:59:59.000Z

322

Modeling Stem Cell Induction Processes  

E-Print Network (OSTI)

Technology for converting human cells to pluripotent stem cell using induction processes has the potential to revolutionize regenerative medicine. However, the production of these so called iPS cells is still quite inefficient ...

Grcio, Filipe

323

Eurographics Workshop on Visual Computing for Biomedicine (2008) C. P. Botha, G. Kindlmann, W. J. Niessen, and B. Preim (Editors)  

E-Print Network (OSTI)

segmentation of the vessel system or direct volume rendering. Categories and Subject Descriptors (according-cerebral tissue classes like fat, bone marrow and eyes due to the similar intensity distribution and connections

Lübeck, Universität zu

324

Corrosion Test Cell For Bipolar Plates  

NLE Websites -- All DOE Office Websites (Extended Search)

Corrosion Test Cell For Bipolar Plates Corrosion Test Cell For Bipolar Plates A corrosion test cell for evaluating corrosion resistance in fuel cell bipolar plates is described....

325

Solar Cells Hellas SA | Open Energy Information  

Open Energy Info (EERE)

Cells Hellas SA Jump to: navigation, search Name Solar Cells Hellas SA Place Athens, Greece Product Greek manufacturer of PV wafers, cells and modules. References Solar Cells...

326

DOE Fuel Cell Technologies Office  

NLE Websites -- All DOE Office Websites (Extended Search)

500 2007 2013 Cumulative Number of Patents Fuel Cells ProductionDelivery Storage * DOE funding has led to 40 commercial hydrogen and fuel cell technologies and 65 emerging...

327

Fuel Cell Technologies Office: Multimedia  

NLE Websites -- All DOE Office Websites (Extended Search)

Energy Efficiency and Renewable Energy EERE Home | Programs & Offices | Consumer Information Fuel Cell Technologies Office Search Search Help Fuel Cell Technologies Office HOME...

328

Fuel Cell Technologies Office: Budget  

NLE Websites -- All DOE Office Websites (Extended Search)

Energy Efficiency and Renewable Energy EERE Home | Programs & Offices | Consumer Information Fuel Cell Technologies Office Search Search Help Fuel Cell Technologies Office HOME...

329

NIST: NIF - PEM Fuel Cells  

Science Conference Proceedings (OSTI)

... Fuel cells are operationally equivalent to a battery. The reactants or fuel in a fuel cell can be replaced unlike a standard disposable or rechargeable ...

330

Fuel Cells | Open Energy Information  

Open Energy Info (EERE)

Datasets Community Login | Sign Up Search Page Edit History Facebook icon Twitter icon Fuel Cells Jump to: navigation, search TODO: Add description List of Fuel Cells Incentives...

331

Fuel Cell Technologies Office: Education  

NLE Websites -- All DOE Office Websites (Extended Search)

& Local Governments For Early Adopters For Students & Educators Careers in Hydrogen & Fuel Cells Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells...

332

Fuel Cell Technologies Overview  

NLE Websites -- All DOE Office Websites (Extended Search)

States Energy Advisory Board (STEAB) States Energy Advisory Board (STEAB) Washington, DC Dr. Sunita Satyapal U.S. Department of Energy Fuel Cell Technologies Program Program Manager 3/14/2012 2 | Fuel Cell Technologies Program Source: US DOE 3/19/2013 eere.energy.gov * Introduction - Technology and Market Overview * DOE Program Overview - Mission & Structure - R&D Progress - Demonstration & Deployments * State Activities - Examples of potential opportunities Outline 3 | Fuel Cell Technologies Program Source: US DOE 3/19/2013 eere.energy.gov Fuel cells - convert chemical energy directly into electrical energy, bypassing inefficiencies associated with thermal energy conversion. Available energy is equal to the Gibbs free energy. Combustion Engines - convert chemical energy into thermal energy and

333

Batteries and Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Collage of electric cars, plug, battery research lab Collage of electric cars, plug, battery research lab Batteries and Fuel Cells EETD researchers study the basic science and development of advanced batteries and fuel cells for transportation, electric grid storage, and other stationary applications. This research is aimed at developing more environmentally friendly technologies for generating and storing energy, including better batteries and fuel cells. Li-Ion and Other Advanced Battery Technologies Research conducted here on battery technology is aimed at developing low-cost rechargeable advanced electrochemical batteries for both automotive and stationary applications. The goal of fuel cell research is to provide the technologies for the successful commercialization of polymer-electrolyte and solid oxide fuel

334

Solar cell array interconnects  

DOE Patents (OSTI)

Electrical interconnects are disclosed for solar cells or other electronic components using a silver-silicone paste or a lead-tin (Pb-Sn) no-clean fluxless solder cream, whereby the high breakage of thin (<6 mil thick) solar cells using conventional solder interconnect is eliminated. The interconnects of this invention employs copper strips which are secured to the solar cells by a silver-silicone conductive paste which can be used at room temperature, or by a Pb-Sn solder cream which eliminates undesired residue on the active surfaces of the solar cells. Electrical testing using the interconnects of this invention has shown that no degradation of the interconnects developed under high current testing, while providing a very low contact resistance value. 4 figs.

Carey, P.G.; Thompson, J.B.; Colella, N.J.; Williams, K.A.

1995-11-14T23:59:59.000Z

335

T Plant Cell Investigation  

Science Conference Proceedings (OSTI)

The Waste Management Project within Fluor Hanford performed an initial investigation of the current and historical contents of 221-T (T Plant Canyon) process cells. This Phase I report is intended to be followed by a final, more detailed, Phase II report. This information has been gathered in order to help reduce uncertainties and future surprises regarding cell contents during future work in and around T Plant process cells. The information was obtained from available documentation and was compiled into a database that is included in the report. Resolution of any apparently conflicting information was not a part of the Phase I effort. No information has been found to date that would indicate there could be a significant unexpected hazard in any of the process cells.

HLADEK, K.L.

2001-09-20T23:59:59.000Z

336

Microbubble cell actuator  

E-Print Network (OSTI)

The field of microsystems technology is rapidly growing, and expanding its horizons to applications in bioengineering. Currently, there are no cell analysis systems that facilitate the collection of dynamic responses for ...

Braff, Rebecca A. (Rebecca Alice)

1999-01-01T23:59:59.000Z

337

Microbial Capacitive Desalination Cell  

A research team led by Dr. Jason Ren of the University of Colorado has developed novel microbial capacitive desalination cell (MCDC) technology for sustainable desalination, renewable energy production, and wastewater treatment solution.

338

HIV entering the cell  

NLE Websites -- All DOE Office Websites (Extended Search)

NA Question: How does the HIV virus enter the cell, is it through active transport or passive? Could it be endocytosis? Replies: None of these, usually. Many viruses, T4 for...

339

Photovoltaic Cell Performance  

Energy.gov (U.S. Department of Energy (DOE))

Photovoltaic (PV), or solar cells use the energy in sunlight to produce electricity. However, the amount of electricity produced depends on the quality of the light available and the performance of...

340

Photovoltaic solar cell  

DOE Patents (OSTI)

A photovoltaic solar cell for generating electricity from sunlight is disclosed. The photovoltaic solar cell comprises a plurality of spaced-apart point contact junctions formed in a semiconductor body to receive the sunlight and generate the electicity therefrom, the plurality of spaced-apart point contact junctions having a first plurality of regions having a first doping type and a second plurality of regions having a second doping type. In addition, the photovoltaic solar cell comprises a first electrical contact electrically connected to each of the first plurality of regions and a second electrical contact electrically connected to each of the second plurality of regions, as well as a passivation layer covering major surfaces and sidewalls of the photovoltaic solar cell.

Nielson, Gregory N; Okandan, Murat; Cruz-Campa, Jose Luis; Resnick, Paul J

2013-11-26T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
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341

Energy Basics: Photovoltaic Cells  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

mounting hardware, power-conditioning equipment, and batteries that store solar energy for use when the sun is not shining. When light shines on a PV cell, it may be...

342

Solar cell array interconnects  

DOE Patents (OSTI)

Electrical interconnects for solar cells or other electronic components using a silver-silicone paste or a lead-tin (Pb-Sn) no-clean fluxless solder cream, whereby the high breakage of thin (<6 mil thick) solar cells using conventional solder interconnect is eliminated. The interconnects of this invention employs copper strips which are secured to the solar cells by a silver-silicone conductive paste which can be used at room temperature, or by a Pb-Sn solder cream which eliminates undesired residue on the active surfaces of the solar cells. Electrical testing using the interconnects of this invention has shown that no degradation of the interconnects developed under high current testing, while providing a very low contact resistance value.

Carey, Paul G. (Mountain View, CA); Thompson, Jesse B. (Brentwood, CA); Colella, Nicolas J. (Livermore, CA); Williams, Kenneth A. (Livermore, CA)

1995-01-01T23:59:59.000Z

343

Hydrogen & Fuel Cells  

Energy.gov (U.S. Department of Energy (DOE))

The U.S. Department of Energy (DOE) is the lead federal agency for applied research and development (R&D) of cutting edge hydrogen and fuel cell technologies. DOE supports R&D that makes it...

344

Thin film photovoltaic cells  

DOE Patents (OSTI)

A solar cell has as its transparent electrical contact a grid made from a non-noble metal by providing a layer of copper oxide between the transparent electrical contact and the absorber-generator.

Rothwarf, Allen (Philadelphia, PA)

1981-01-01T23:59:59.000Z

345

Teaching cell respiration  

NLE Websites -- All DOE Office Websites (Extended Search)

I am tearing my hair out trying to teach the subject of Cell Respiration and photosynthesis to students that are in some cases on a basic skills level of understanding. How...

346

Hydrogen and Fuel Cells  

Energy.gov (U.S. Department of Energy (DOE))

The U.S. Department of Energy (DOE) is the lead federal agency for applied research and development (R&D) of cutting edge hydrogen and fuel cell technologies. DOE supports R&D that makes it...

347

Composite fuel cell membranes  

DOE Patents (OSTI)

A bilayer or trilayer composite ion exchange membrane is described suitable for use in a fuel cell. The composite membrane has a high equivalent weight thick layer in order to provide sufficient strength and low equivalent weight surface layers for improved electrical performance in a fuel cell. In use, the composite membrane is provided with electrode surface layers. The composite membrane can be composed of a sulfonic fluoropolymer in both core and surface layers.

Plowman, K.R.; Rehg, T.J.; Davis, L.W.; Carl, W.P.; Cisar, A.J.; Eastland, C.S.

1997-08-05T23:59:59.000Z

348

Ice electrode electrolytic cell  

DOE Patents (OSTI)

This invention relates to a method and apparatus for removing heavy metals from waste water, soils, or process streams by electrolytic cell means. The method includes cooling a cell cathode to form an ice layer over the cathode and then applying an electric current to deposit a layer of the heavy metal over the ice. The metal is then easily removed after melting the ice. In a second embodiment, the same ice-covered electrode can be employed to form powdered metals.

Glenn, David F. (Idaho Falls, ID); Suciu, Dan F. (Idaho Falls, ID); Harris, Taryl L. (Idaho Falls, ID); Ingram, Jani C. (Idaho Falls, ID)

1993-01-01T23:59:59.000Z

349

Ice electrode electrolytic cell  

DOE Patents (OSTI)

This invention relates to a method and apparatus for removing heavy metals from waste water, soils, or process streams by electrolytic cell means. The method includes cooling a cell cathode to form an ice layer over the cathode and then applying an electric current to deposit a layer of the heavy metal over the ice. The metal is then easily removed after melting the ice. In a second embodiment, the same ice-covered electrode can be employed to form powdered metals.

Glenn, D.F.; Suciu, D.F.; Harris, T.L.; Ingram, J.C.

1993-04-06T23:59:59.000Z

350

Aluminum reduction cell electrode  

DOE Patents (OSTI)

The invention is directed to cathode modules comprised of refractory hard metal materials, such as TiB[sub 2], for an electrolytic cell for the reduction of alumina wherein the modules may be installed and replaced during operation of the cell and wherein the structure of the cathode modules is such that the refractory hard metal materials are not subjected to externally applied forces or rigid constraints. 9 figs.

Goodnow, W.H.; Payne, J.R.

1982-09-14T23:59:59.000Z

351

Ice electrode electrolytic cell  

DOE Patents (OSTI)

This invention relates to a method and apparatus for removing heavy metals from waste water, soils, or process streams by electrolytic cell means. The method includes cooling a cell cathode to form an ice layer over the cathode and then applying an electric current to deposit a layer of the heavy metal over the ice. The metal is then easily removed after melting the ice. In a second embodiment, the same ice-covered electrode can be employed to form powdered metals.

Glenn, D.F.; Suciu, D.F.; Harris, T.L.; Ingram, J.C.

1992-12-31T23:59:59.000Z

352

Monolithic tandem solar cell  

DOE Patents (OSTI)

It is an object of the invention to provide a monolithic tandem photovoltaic solar cell which is highly radiation resistant and efficient; in which the energy bandgap of the lower subcell can be tailored for specific applications; solar cell comprising layers of InP and GaInAsP (or GaInAs), where said photovoltaic cell is useful, for example, in space power applications; having an improved power-to-mass ratio; in which subcells are lattice-matches; and are both two terminal and three terminal monolithic tandem photovoltaic solar cells. To achieve the foregoing and other objects and in accordance with the purpose of the present invention, as embodied and broadly described herein, the monolithic tandem photovoltaic solar cell may comprise; (a) an InP substrate having an upper surface; (b) a first photoactive subcell on the upper surface of the InP substrate; wherein the first subcell comprises GaInAs (which could include GaInAsP) and includes a homojunction; and (c) a second photoactive subcell on the first subcell; wherein the second subcell comprises InP and includes a homojunction. The cell is described in detail. 5 figs., 2 tabs.

Wanlass, M.W.

1989-11-03T23:59:59.000Z

353

Fuel cell system  

DOE Patents (OSTI)

A fuel cell system is comprised of a fuel cell module including sub-stacks of series-connected fuel cells, the sub-stacks being held together in a stacked arrangement with cold plates of a cooling means located between the sub-stacks to function as electrical terminals. The anode and cathode terminals of the sub-stacks are connected in parallel by means of the coolant manifolds which electrically connect selected cold plates. The system may comprise a plurality of the fuel cell modules connected in series. The sub-stacks are designed to provide a voltage output equivalent to the desired voltage demand of a low voltage, high current DC load such as an electrolytic cell to be driven by the fuel cell system. This arrangement in conjunction with switching means can be used to drive a DC electrical load with a total voltage output selected to match that of the load being driven. This arrangement eliminates the need for expensive voltage regulation equipment.

Early, Jack (Perth Amboy, NJ); Kaufman, Arthur (West Orange, NJ); Stawsky, Alfred (Teaneck, NJ)

1982-01-01T23:59:59.000Z

354

FUEL CELL TECHNOLOGIES PROGRAM Hydrogen and fuel cells offer great  

E-Print Network (OSTI)

and electricity for fuel cell and plug-in hybrid electric vehicles while using proven stationary fuel cell technol vehicles with its own fuel cell technology. Currently, advanced vehicle technologies are being evalu- ated in addition to hydrogen fuel for local demonstration fuel cell vehicles. As advanced vehicles begin to enter

355

The relationship between the bone mineral density and urinary cadmium concentration of residents in an industrial complex  

SciTech Connect

Background: An association between cadmium exposure and bone mineral density (BMD) has been demonstrated in elderly women, but has not been well studied in youths and men. Some studies report either no or a weak association between cadmium exposure and bone damage. Objectives: This study was designed to investigate the relationship between the urinary cadmium (U-Cd) levels and BMD of females and males of all ages. Methods: A total of 804 residents near an industrial complex were surveyed in 2007. U-Cd and BMD on the heel (non-dominant calcaneus) were analyzed with AAS-GTA and Dual-Energy X-ray absorptiometry, respectively. Demographic characteristics were collected by structured questionnaires. Osteoporosis and osteopenia were defined by BMD cut-off values and T-scores set by the WHO; T score>-1, normal; -2.5=}1.0 {mu}g/g creatinine) in females (OR=2.92; 95% CI, 1.51-5.64) and in males (OR=3.37; 95% CI, 1.09-10.38). With the multiple linear regression model, the BMD of the adult group was negatively associated with U-Cd (<0.05), gender (female, p<0.001) and age (p<0.001). The BMD of participants who were {<=}19 years of age was negatively associated with gender (female, p<0.01), whereas it was positively associated with age and BMI (p<0.001). BMD was not associated with exercise, smoking habits, alcohol consumption, job or parental education. Conclusion: Results suggested that U-Cd might be associated with osteopenia as well as osteoporosis in both male and female adults. Age and female gender were negatively associated with BMD in the adult group, whereas age was positively associated with BMD in the youth group. Cadmium exposure may be a potential risk factor for lower-BMD and osteopenia symptoms as well as for osteoporosis symptoms. - Research Highlights: {yields} The relationship between the urinary cadmium levels and BMD was investigated. {yields} U-Cd was associated with osteopenia and osteoporosis in adults. {yields} Cadmium exposure may be a potential risk factor for lower-BMD and osteopenia.

Shin, Minah; Paek, Domyung [Institute of Health and Environment, Department of Environmental Health, School of Public Health, Seoul National University, Gwanak-599, Gwanak-gu, Seoul 151-742 (Korea, Republic of)] [Institute of Health and Environment, Department of Environmental Health, School of Public Health, Seoul National University, Gwanak-599, Gwanak-gu, Seoul 151-742 (Korea, Republic of); Yoon, Chungsik, E-mail: csyoon@snu.ac.kr [Institute of Health and Environment, Department of Environmental Health, School of Public Health, Seoul National University, Gwanak-599, Gwanak-gu, Seoul 151-742 (Korea, Republic of)] [Institute of Health and Environment, Department of Environmental Health, School of Public Health, Seoul National University, Gwanak-599, Gwanak-gu, Seoul 151-742 (Korea, Republic of)

2011-01-15T23:59:59.000Z

356

Seventh Edition Fuel Cell Handbook  

DOE Green Energy (OSTI)

Provides an overview of fuel cell technology and research projects. Discusses the basic workings of fuel cells and their system components, main fuel cell types, their characteristics, and their development status, as well as a discussion of potential fuel cell applications.

NETL

2004-11-01T23:59:59.000Z

357

Breakthrough Vehicle Development - Fuel Cells  

Fuel Cell Technologies Publication and Product Library (EERE)

Document describing research and development program for fuel cell power systems for transportation applications.

358

FUEL CELL TECHNOLOGIES PROGRAM Technologies  

E-Print Network (OSTI)

.eere.energy.gov/informationcenter hydrogen and electricity for fuel cell and plug-in hybrid electric vehicles while using proven stationary vehicles with its own fuel cell technology. Currently, advanced vehicle technologies are being evalu- ated and fuel cells offer great promise for our energy future. Fuel cell vehicles are not yet commercially

359

Argonne TDC: Fuel Cell Technologies  

Emergency Response. Engineering. Environmental Research. Fuel Cells. Imaging Technology. Material Science. Nanotechnology. Physical Sciences. Sensor ...

360

Fuel Cell Technologies Office: Presentations  

NLE Websites -- All DOE Office Websites (Extended Search)

Presentations to Presentations to someone by E-mail Share Fuel Cell Technologies Office: Presentations on Facebook Tweet about Fuel Cell Technologies Office: Presentations on Twitter Bookmark Fuel Cell Technologies Office: Presentations on Google Bookmark Fuel Cell Technologies Office: Presentations on Delicious Rank Fuel Cell Technologies Office: Presentations on Digg Find More places to share Fuel Cell Technologies Office: Presentations on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings Annual Merit Review Proceedings Workshop & Meeting Proceedings Webinars Data Records Databases Glossary Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
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We encourage you to perform a real-time search of NLEBeta
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361

Fuel Cell Technologies Office: Glossary  

NLE Websites -- All DOE Office Websites (Extended Search)

Glossary to someone by Glossary to someone by E-mail Share Fuel Cell Technologies Office: Glossary on Facebook Tweet about Fuel Cell Technologies Office: Glossary on Twitter Bookmark Fuel Cell Technologies Office: Glossary on Google Bookmark Fuel Cell Technologies Office: Glossary on Delicious Rank Fuel Cell Technologies Office: Glossary on Digg Find More places to share Fuel Cell Technologies Office: Glossary on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings Webinars Data Records Databases Glossary Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells Technology Validation Manufacturing Codes & Standards Education Systems Analysis Contacts Glossary

362

Electrochemical cell operation and system  

DOE Patents (OSTI)

Thermal control in fuel cell operation is affected through sensible heat of process gas by providing common input manifolding of the cell gas flow passage in communication with the cell electrolyte and an additional gas flow passage which is isolated from the cell electrolyte and in thermal communication with a heat-generating surface of the cell. Flow level in the cell gas flow passage is selected based on desired output electrical energy and flow level in the additional gas flow passage is selected in accordance with desired cell operating temperature.

Maru, Hansraj C. (Brookfield Center, CT)

1980-03-11T23:59:59.000Z

363

Device for monitoring cell voltage  

SciTech Connect

A device for monitoring a rechargeable battery having a number of electrically connected cells includes at least one current interruption switch for interrupting current flowing through at least one associated cell and a plurality of monitoring units for detecting cell voltage. Each monitoring unit is associated with a single cell and includes a reference voltage unit for producing a defined reference threshold voltage and a voltage comparison unit for comparing the reference threshold voltage with a partial cell voltage of the associated cell. The reference voltage unit is electrically supplied from the cell voltage of the associated cell. The voltage comparison unit is coupled to the at least one current interruption switch for interrupting the current of at least the current flowing through the associated cell, with a defined minimum difference between the reference threshold voltage and the partial cell voltage.

Doepke, Matthias (Garbsen, DE); Eisermann, Henning (Edermissen, DE)

2012-08-21T23:59:59.000Z

364

Effects of Radiation on Adaptive Immunity: Contact Hypersensitivity Model  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation on Adaptive Immunity: Contact Hypersensitivity Model Radiation on Adaptive Immunity: Contact Hypersensitivity Model Gregory Nelson Loma Linda University Abstract It has long been appreciated that cells of the immune system are radiosensitive and use apoptosis as the primary mechanism of cell death following injury. The hypervariability of the immunoglobulin superfamily of genes expressed in lymphoid cells also led to the appreciation of the nonhomologous end joining mechanism of DNA repair. Clinically, whole body irradiation is used in treatment of some lymphomas and as an immunosuppressive agent for bone marrow transplants. Inflammation at sites of radiotherapy is a common side effect. Many studies with radiation have addressed the changes in cell populations following radiation exposure and have shown a reproducible pattern of relative sensitivities amongst

365

Cell Phone Detection Techniques  

Science Conference Proceedings (OSTI)

A team composed of Rick Pratt, Dave Puczyki, Kyle Bunch, Ryan Slaugh, Morris Good, and Doug McMakin teamed together to attempt to exploit cellular telephone features and detect if a person was carrying a cellular telephone into a Limited Area. The cell phones electromagnetic properties were measured, analyzed, and tested in over 10 different ways to determine if an exploitable signature exists. The method that appears to have the most potential for success without adding an external tag is to measure the RF spectrum, not in the cell phone band, but between 240 and 400MHz. Figures 1- 7 show the detected signal levels from cell phones from three different manufacturers.

Pratt, Richard M.; Bunch, Kyle J.; Puzycki, David J.; Slaugh, Ryan W.; Good, Morris S.; McMakin, Douglas L.

2007-10-01T23:59:59.000Z

366

PEM FUEL CELL TURBOCOMPRESSOR  

DOE Green Energy (OSTI)

The objective is to assist the Department of Energy in the development of a low cost, reliable and high performance air compressor/expander. Technical Objective 1: Perform a turbocompressor systems PEM fuel cell trade study to determine the enhanced turbocompressor approach. Technical Objective 2: Using the results from technical objective 1, an enhanced turbocompressor will be fabricated. The design may be modified to match the flow requirements of a selected fuel cell system developer. Technical Objective 3: Design a cost and performance enhanced compact motor and motor controller. Technical Objective 4: Turbocompressor/motor controller development.

Mark K. Gee

2004-04-01T23:59:59.000Z

367

Monolithic tandem solar cell  

DOE Patents (OSTI)

A single-crystal, monolithic, tandem, photovoltaic solar cell is described which includes (a) an InP substrate having upper and lower surfaces, (b) a first photoactive subcell on the upper surface of the InP substrate, and (c) a second photoactive subcell on the first subcell. The first photoactive subcell is GaInAsP of defined composition. The second subcell is InP. The two subcells are lattice matched. The solar cell can be provided as a two-terminal device or a three-terminal device.

Wanlass, Mark W. (Golden, CO)

1991-01-01T23:59:59.000Z

368

Fuel cell stack arrangements  

DOE Patents (OSTI)

Arrangements of stacks of fuel cells and ducts, for fuel cells operating with separate fuel, oxidant and coolant streams. An even number of stacks are arranged generally end-to-end in a loop. Ducts located at the juncture of consecutive stacks of the loop feed oxidant or fuel to or from the two consecutive stacks, each individual duct communicating with two stacks. A coolant fluid flows from outside the loop, into and through cooling channels of the stack, and is discharged into an enclosure duct formed within the loop by the stacks and seals at the junctures at the stacks.

Kothmann, Richard E. (Churchill Boro, PA); Somers, Edward V. (Murrysville, PA)

1982-01-01T23:59:59.000Z

369

Amorphous semiconductor solar cell  

SciTech Connect

A solar cell comprising a back electrical contact, amorphous silicon semiconductor base and junction layers and a top electrical contact includes in its manufacture the step of heat treating the physical junction between the base layer and junction layer to diffuse the dopant species at the physical junction into the base layer.

Dalal, Vikram L. (Newark, DE)

1981-01-01T23:59:59.000Z

370

Integrated photovoltaic electrolytic cell  

SciTech Connect

A photovoltaic-electrolytic unit is provided to produce an electric current from solar energy and utilize the current to produce hydrogen by the electrolysis of water. The unit floats in an aqueous medium so that photoelectric cells are exposed to solar radiation, and electrodes submerged in the medium produce oxygen which is vented and hydrogen which is collected in the unit.

Ohkawa, T.

1982-10-05T23:59:59.000Z

371

Improved photoelectrodialytic cell  

DOE Patents (OSTI)

A multicompartment photoelectrodialytic demineralization cell is provided with a buffer compartment interposed between the product compartment and a compartment containing an electrolyte solution. Semipermeable membranes separate the buffer compartment from the product and electrolyte compartments. The buffer compartment is flushed to prevent leakage of the electrolyte compartment from entering the product compartment.

Murphy, G.W.

1981-08-14T23:59:59.000Z

372

Thin film photovoltaic cell  

DOE Patents (OSTI)

A thin film photovoltaic cell having a transparent electrical contact and an opaque electrical contact with a pair of semiconductors therebetween includes utilizing one of the electrical contacts as a substrate and wherein the inner surface thereof is modified by microroughening while being macro-planar.

Meakin, John D. (Newark, DE); Bragagnolo, Julio (Newark, DE)

1982-01-01T23:59:59.000Z

373

The roles of Rb, p107, and E2f4 in bone formation and embryonic development  

E-Print Network (OSTI)

The pocket proteins, through their interaction with the E2F transcription factors, ensure the proper regulation of cell proliferation. By doing so, these protein complexes affect other fundamental processes such as ...

Berman, Seth D

2007-01-01T23:59:59.000Z

374

Fuel Cell Handbook, Fourth Edition  

DOE Green Energy (OSTI)

sections have been updated from the previous edition. New information indicates that manufacturers have stayed with proven cell designs, focusing instead on advancing the system surrounding the fuel cell to lower life cycle costs. Section 7, Fuel Cell Systems, has been significantly revised to characterize near-term and next-generation fuel cell power plant systems at a conceptual level of detail. Section 8 provides examples of practical fuel cell system calculations. A list of fuel cell URLs is included in the Appendix. A new index assists the reader in locating specific information quickly.

Stauffer, D.B; Hirschenhofer, J.H.; Klett, M.G.; Engleman, R.R.

1998-11-01T23:59:59.000Z

375

Solar Cells: Spin-Cast Bulk Heterojunction Solar Cells: A Dynamical...  

NLE Websites -- All DOE Office Websites (Extended Search)

Solar Cells: Spin-Cast Bulk Heterojunction Solar Cells: A Dynamical Investigation Solar Cells: Spin-Cast Bulk Heterojunction Solar Cells: A Dynamical Investigation Print Wednesday,...

376

Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cell Bus Workshop Fuel Cell Bus Workshop The U.S. Department of Energy (DOE) and the U.S. Department of Transportation (DOT) held a Fuel Cell Bus Workshop on June 7, 2010 in Washington, D.C. in conjunction with the DOE Hydrogen and Fuel Cell Program Annual Merit Review. The workshop plenary and breakout session brought together technical experts from industry, end users, academia, DOE national laboratories, and other government agencies to address the status and technology needs of fuel cell powered buses. Meeting Summary Joint Fuel Cell Bus Workshop Summary Report Presentations Fuel Cell Bus Workshop Overview & Purpose, Dimitrios Papageorgopoulos, DOE Users Perspective on Advanced Fuel Cell Bus Technology, Nico Bouwkamp, CaFCP and Leslie Eudy, NREL Progress and Challenges for PEM Transit Fleet Applications, Tom Madden, UTC Power, LLC

377

Stationary Fuel Cells: Overview of Hydrogen and Fuel Cell Activities  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

& & Renewable Energy Stationary Fuel Cells: Overview of Hydrogen and Fuel Cell Activities Pete Devlin Fuel Cell Technologies Program United States Department of Energy Federal Utility Partnership Working Group April 14 th , 2010 2 * DOE Fuel Cell Market Transformation Overview * Overview of CHP Concept * Stationary Fuel Cells for CHP Applications * Partnering and Financing (Sam Logan) * Example Project Outline 3 Fuel Cells: Addressing Energy Challenges Energy Efficiency and Resource Diversity  Fuel cells offer a highly efficient way to use diverse fuels and energy sources. Greenhouse Gas Emissions and Air Pollution:  Fuel cells can be powered by emissions-free fuels that are produced from clean, domestic resources. Stationary Power (including CHP & backup power)

378

DOE Hydrogen and Fuel Cells Program: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cell Technologies Office FY2014 Budget Request Briefing on April 12 Apr 9, 2013 The Fuel Cell Technologies Office will hold a budget briefing for stakeholders on Friday, April...

379

Fuel Cell Technologies Office: Hydrogen and Fuel Cell Manufacturing...  

NLE Websites -- All DOE Office Websites (Extended Search)

and Fuel Cell Manufacturing R&D Workshop The National Renewable Energy Laboratory (NREL) hosted a Hydrogen and Fuel Cell Manufacturing R&D Workshop August 11-12, 2011, in...

380

Fuel Cell Technologies Office: Biogas and Fuel Cells Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Biogas and Fuel Cells Workshop The U.S. Department of Energy's (DOE's) National Renewable Energy Laboratory (NREL) held a Biogas and Fuel Cells Workshop June 11-13, 2012, in...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
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We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Fuel Cell Technologies Office: Flow Cells for Energy Storage...  

NLE Websites -- All DOE Office Websites (Extended Search)

Flow Cells for Energy Storage Workshop The U.S. Department of Energy's (DOE) Lawrence Berkeley National Laboratory (LBNL) held a Flow Cells for Energy Storage Workshop on March...

382

Fuel Cell Technologies Office: New Fuel Cell Projects Meeting  

NLE Websites -- All DOE Office Websites (Extended Search)

Agenda (PDF 83 KB) New Fuel Cell Projects Overview (PDF 1.2 MB), P. Davis, DOE New Fuel Cell Projects Overview (PDF 609 KB), N. Garland, DOE Membranes Membranes and MEAs for Dry,...

383

NREL: Hydrogen and Fuel Cells Research - Fuel Cell Electric Vehicle...  

NLE Websites -- All DOE Office Websites (Extended Search)

the cost and increasing the performance of fuel cell propulsion systems, and most major vehicle manufacturers are geared to launch fuel cell electric vehicles in the U.S. market...

384

DOE Hydrogen and Fuel Cells Program: Hydrogen and Fuel Cells...  

NLE Websites -- All DOE Office Websites (Extended Search)

Hydrogen and Fuel Cells Program Presents Annual Merit Review Awards May 21, 2013 The U.S. Department of Energy's (DOE's) Hydrogen and Fuel Cells Program presented its annual awards...

385

Fuel Cell Handbook, Fourth Edition  

SciTech Connect

Robust progress has been made in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in January 1994. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultra high efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 6 describe the four major fuel cell types and their performance based on cell operating conditions. The section on polymer electrolyte membrane fuel cells has been added to reflect their emergence as a significant fuel cell technology. Phosphoric acid, molten carbonate, and solid oxide fuel cell technology description sections have been updated from the previous edition. New information indicates that manufacturers have stayed with proven cell designs, focusing instead on advancing the system surrounding the fuel cell to lower life cycle costs. Section 7, Fuel Cell Systems, has been significantly revised to characterize near-term and next-generation fuel cell power plant systems at a conceptual level of detail. Section 8 provides examples of practical fuel cell system calculations. A list of fuel cell URLs is included in the Appendix. A new index assists the reader in locating specific information quickly.

Stauffer, D.B; Hirschenhofer, J.H.; Klett, M.G.; Engleman, R.R.

1998-11-01T23:59:59.000Z

386

Inhibition of cell-cell binding by lipid assemblies  

DOE Patents (OSTI)

This invention relates generally to the field of therapeutic compounds designed to interfere between the binding of ligands and their receptors on cell surface. More specifically, it provides products and methods for inhibiting cell migration and activation using lipid assemblies with surface recognition elements that are specific for the receptors involved in cell migration and activation.

Nagy, Jon O. (Rodeo, CA); Bargatze, Robert F. (Bozeman, MT)

2001-05-22T23:59:59.000Z

387

EE580 Solar Cells Todd J. Kaiser  

E-Print Network (OSTI)

7/21/2010 1 EE580 ­ Solar Cells Todd J. Kaiser · Lecture 06 · Solar Cell Materials & Structures 1Montana State University: Solar Cells Lecture 6: Solar Cells Solar Cell Technologies · A) Crystalline Silicon · B) Thin Film · C) Group III-IV Cells 2Montana State University: Solar Cells Lecture 6: Solar

Kaiser, Todd J.

388

Actin remodeling in motile cells  

E-Print Network (OSTI)

Non-muscle cell shape change and motility depend primarily on the dynamics and distributions of cytoplasmic actin. In cells, actin cycles between monomeric and polymeric phases tightly regulated by actin binding proteins ...

Osborn, Eric A. (Eric Alan), 1975-

2004-01-01T23:59:59.000Z

389

Fuel Cell Technologies Office: Multimedia  

NLE Websites -- All DOE Office Websites (Extended Search)

uses of fuel cell technologies. MotorWeek H2 on the Horizon Video Learn how car makers, energy suppliers, and the government are bringing fuel cell electric vehicles and hydrogen...

390

Fuel Cell Technologies Office: Databases  

NLE Websites -- All DOE Office Websites (Extended Search)

Efficiency and Renewable Energy Fuel Cell Technologies Office Databases The Fuel Cell Technologies Office is developing databases to make it easier for users to find up-to-date...

391

Energy Basics: Fuel Cell Vehicles  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

EERE: Energy Basics Fuel Cell Vehicles Photo of a blue car with 'The Road to Hydrogen' written on it, filling up at a hydrogen fueling station. Fuel cell vehicles, powered by...

392

Fuel Cell Projects Kickoff Meeting  

NLE Websites -- All DOE Office Websites (Extended Search)

of Cost-Competitive Fuel Cell Stacks James Cross, Nuvera 4:30 Fuel Cell Fundamentals at Low and Subzero Temperatures Adam Weber, LBNL 4:50 Development and Validation of...

393

Fuel Cell Technologies Office: Events  

NLE Websites -- All DOE Office Websites (Extended Search)

Events Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Events to someone by E-mail Share Fuel Cell Technologies Office: Events on Facebook Tweet...

394

DOE Fuel Cell Subprogram (Presentation)  

NLE Websites -- All DOE Office Websites (Extended Search)

* By 2010, develop a fuel cell system for consumer electronics (<50 W) with an energy density of 1,000 WhL. * By 2010, develop a fuel cell system for auxiliary power units (3-30...

395

2009 Fuel Cell Market Report  

Fuel Cell Technologies Publication and Product Library (EERE)

Fuel cells are electrochemical devices that combine hydrogen and oxygen to produce electricity, water, and heat. Unlike batteries, fuel cells continuously generate electricity, as long as a source of

396

Thermal Management of Solar Cells  

E-Print Network (OSTI)

Nanostructured Silicon- Based Solar Cells, 2013. X. C. Tong,compact heat exchangers, and solar cells," Sci-Tech News,2011. C. J. Chen, Physics of Solar Energy: Wiley, 2011. M.

Saadah, Mohammed Ahmed

2013-01-01T23:59:59.000Z

397

Broad spectrum solar cell  

DOE Patents (OSTI)

An alloy having a large band gap range is used in a multijunction solar cell to enhance utilization of the solar energy spectrum. In one embodiment, the alloy is In.sub.1-xGa.sub.xN having an energy bandgap range of approximately 0.7 eV to 3.4 eV, providing a good match to the solar energy spectrum. Multiple junctions having different bandgaps are stacked to form a solar cell. Each junction may have different bandgaps (realized by varying the alloy composition), and therefore be responsive to different parts of the spectrum. The junctions are stacked in such a manner that some bands of light pass through upper junctions to lower junctions that are responsive to such bands.

Walukiewicz, Wladyslaw (Kensington, CA); Yu, Kin Man (Lafayette, CA); Wu, Junqiao (Richmond, CA); Schaff, William J. (Ithaca, NY)

2007-05-15T23:59:59.000Z

398

Aluminum reduction cell electrode  

DOE Patents (OSTI)

The invention is directed to an anode-cathode structure for an electrolytic cell for the reduction of alumina wherein the structure is comprised of a carbon anode assembly which straddles a wedge-shaped refractory hard metal cathode assembly having steeply sloped cathodic surfaces, each cathodic surface being paired in essentially parallel planar relationship with an anode surface. The anode-cathode structure not only takes into account the structural weakness of refractory hard metal materials but also permits the changing of the RHM assembly during operation of the cell. Further, the anode-cathode structure enhances the removal of anode gas from the interpolar gap between the anode and cathode surfaces. 10 figs.

Payne, J.R.

1983-09-20T23:59:59.000Z

399

Compact fuel cell  

DOE Patents (OSTI)

A novel electrochemical cell which may be a solid oxide fuel cell (SOFC) is disclosed where the cathodes (144, 140) may be exposed to the air and open to the ambient atmosphere without further housing. Current collector (145) extends through a first cathode on one side of a unit and over the unit through the cathode on the other side of the unit and is in electrical contact via lead (146) with housing unit (122 and 124). Electrical insulator (170) prevents electrical contact between two units. Fuel inlet manifold (134) allows fuel to communicate with internal space (138) between the anodes (154 and 156). Electrically insulating members (164 and 166) prevent the current collector from being in electrical contact with the anode.

Jacobson, Craig (Moraga, CA); DeJonghe, Lutgard C. (Lafayette, CA); Lu, Chun (Richland, WA)

2010-10-19T23:59:59.000Z

400

Cell Systems Science Group Staff  

Science Conference Proceedings (OSTI)

*. Bookmark and Share. Members of the Cell Systems Science Group. Dr. John T. Elliott (Group Leader). Dr. Donald H. Atha ...

2013-03-12T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
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to obtain the most current and comprehensive results.


401

Energy Basics: Photovoltaic Cell Structures  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Energy Basics Renewable Energy Printable Version Share this resource Biomass Geothermal Hydrogen Hydropower Ocean Solar Photovoltaics Cells Systems Concentrating Solar...

402

Energy Basics: Photovoltaic Cell Performance  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Energy Basics Renewable Energy Printable Version Share this resource Biomass Geothermal Hydrogen Hydropower Ocean Solar Photovoltaics Cells Systems Concentrating Solar...

403

Energy Basics: Photovoltaic Cell Materials  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Energy Basics Renewable Energy Printable Version Share this resource Biomass Geothermal Hydrogen Hydropower Ocean Solar Photovoltaics Cells Systems Concentrating Solar...

404

Cell Operations and Process Control  

Science Conference Proceedings (OSTI)

Mar 5, 2013 ... Aluminum Reduction Technology: Cell Operations and Process Control Sponsored by: TMS Light Metals Division, TMS: Aluminum Committee

405

Energy Conversion/Fuel Cells  

Science Conference Proceedings (OSTI)

About this Symposium. Meeting, Materials Science & Technology 2011. Symposium, Energy Conversion/Fuel Cells. Sponsorship, MS&T Organization.

406

Fuel Cell Technologies Office: Webinars  

NLE Websites -- All DOE Office Websites (Extended Search)

Databases Glossary Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells Technology Validation Manufacturing Codes & Standards Education Systems...

407

Available Technologies: Electrochemical Environmental Cell ...  

Electrochemical Environmental Cell with Vertical, Aligned Electrodes for TEM IB-3330. ... Energy storage device / battery research and development;

408

Basal cell carcinoma does metastasize  

E-Print Network (OSTI)

Basal cell carcinoma does metastasize Doruk Ozgediz MD 1 ,illustrates that, in fact, BCC does metastasize and if left

Ozgediz, Doruk; Smith, EB; Zheng, Jie; Otero, Jose; Tabatabai, Z Laura; Corvera, Carlos U

2008-01-01T23:59:59.000Z

409

Miniature ceramic fuel cell  

DOE Patents (OSTI)

A miniature power source assembly capable of providing portable electricity is provided. A preferred embodiment of the power source assembly employing a fuel tank, fuel pump and control, air pump, heat management system, power chamber, power conditioning and power storage. The power chamber utilizes a ceramic fuel cell to produce the electricity. Incoming hydro carbon fuel is automatically reformed within the power chamber. Electrochemical combustion of hydrogen then produces electricity.

Lessing, Paul A. (Idaho Falls, ID); Zuppero, Anthony C. (Idaho Falls, ID)

1997-06-24T23:59:59.000Z

410

Fuel cell system combustor  

DOE Patents (OSTI)

A fuel cell system including a fuel reformer heated by a catalytic combustor fired by anode and cathode effluents. The combustor includes a turbulator section at its input end for intimately mixing the anode and cathode effluents before they contact the combustors primary catalyst bed. The turbulator comprises at least one porous bed of mixing media that provides a tortuous path therethrough for creating turbulent flow and intimate mixing of the anode and cathode effluents therein.

Pettit, William Henry (Rochester, NY)

2001-01-01T23:59:59.000Z

411

Carbonate fuel cell matrix  

DOE Patents (OSTI)

A carbonate fuel cell matrix is described comprising support particles and crack attenuator particles which are made platelet in shape to increase the resistance of the matrix to through cracking. Also disclosed is a matrix having porous crack attenuator particles and a matrix whose crack attenuator particles have a thermal coefficient of expansion which is significantly different from that of the support particles, and a method of making platelet-shaped crack attenuator particles. 8 figs.

Farooque, M.; Yuh, C.Y.

1996-12-03T23:59:59.000Z

412

Carbonate fuel cell matrix  

DOE Patents (OSTI)

A carbonate fuel cell matrix comprising support particles and crack attenuator particles which are made platelet in shape to increase the resistance of the matrix to through cracking. Also disclosed is a matrix having porous crack attenuator particles and a matrix whose crack attenuator particles have a thermal coefficient of expansion which is significantly different from that of the support particles, and a method of making platelet-shaped crack attenuator particles.

Farooque, Mohammad (Huntington, CT); Yuh, Chao-Yi (New Milford, CT)

1996-01-01T23:59:59.000Z

413

Securing Cell Relay Networks  

Science Conference Proceedings (OSTI)

A cellular relay or cell relay (CR) is a device used to relay information from one point in a network to another through a wireless medium using spectrum from the cellular band. One common use of CRs in the United States is to provide wireless devices with access to higher bandwidth or broadband access points. Examples include advanced metering infrastructure (AMI) mesh networks that use meter-based transmitters and receivers to provide communications between meters and from ...

2013-12-20T23:59:59.000Z

414

Fuel cell oxygen electrode  

DOE Patents (OSTI)

An oxygen electrode for a fuel cell utilizing an acid electrolyte has a substrate of an alkali metal tungsten bronze of the formula: A.sub.x WO.sub.3 where A is an alkali metal and x is at least 0.2, which is covered with a thin layer of platinum tungsten bronze of the formula: Pt.sub.y WO.sub.3 where y is at least 0.8.

Shanks, Howard R. (Ames, IA); Bevolo, Albert J. (Ames, IA); Danielson, Gordon C. (Ames, IA); Weber, Michael F. (Wichita, KS)

1980-11-04T23:59:59.000Z

415

Fuel cell generator energy dissipator  

DOE Patents (OSTI)

An apparatus and method are disclosed for eliminating the chemical energy of fuel remaining in a fuel cell generator when the electrical power output of the fuel cell generator is terminated. During a generator shut down condition, electrically resistive elements are automatically connected across the fuel cell generator terminals in order to draw current, thereby depleting the fuel

Veyo, Stephen Emery (Murrysville, PA); Dederer, Jeffrey Todd (Valencia, PA); Gordon, John Thomas (Ambridge, PA); Shockling, Larry Anthony (Pittsburgh, PA)

2000-01-01T23:59:59.000Z

416

Fuel cell sub-assembly  

DOE Patents (OSTI)

A fuel cell sub-assembly comprising a plurality of fuel cells, a first section of a cooling means disposed at an end of the assembly and means for connecting the fuel cells and first section together to form a unitary structure.

Chi, Chang V. (Brookfield, CT)

1983-01-01T23:59:59.000Z

417

Nanostructured plasmonics silicon solar cells  

Science Conference Proceedings (OSTI)

We report a plasmonics silicon solar cell design, with the possibility of lower cost and higher efficiency. The proposed solar cell consists of a radial p-n junction silicon nanopillar arrays in combination with metallic nanoparticles resolved at the ... Keywords: Antireflection coating, Optical absorption, Power conversion efficiency, Solar cells

Pushpa Raj Pudasaini, Arturo A. Ayon

2013-10-01T23:59:59.000Z

418

Method for fabricating silicon cells  

DOE Patents (OSTI)

A process is described for making high-efficiency solar cells. This is accomplished by forming a diffusion junction and a passivating oxide layer in a single high-temperature process step. The invention includes the class of solar cells made using this process, including high-efficiency solar cells made using Czochralski-grown silicon. 9 figs.

Ruby, D.S.; Basore, P.A.; Schubert, W.K.

1998-08-11T23:59:59.000Z

419

Method for fabricating silicon cells  

DOE Patents (OSTI)

A process for making high-efficiency solar cells. This is accomplished by forming a diffusion junction and a passivating oxide layer in a single high-temperature process step. The invention includes the class of solar cells made using this process, including high-efficiency solar cells made using Czochralski-grown silicon.

Ruby, Douglas S. (Albuquerque, NM); Basore, Paul A. (Albuquerque, NM); Schubert, W. Kent (Albuquerque, NM)

1998-08-11T23:59:59.000Z

420

Commercialization of fuel-cells  

DOE Green Energy (OSTI)

This report is an abbreviated version of the ''Report of the DOE Advanced Fuel Cell Commercialization Working Group (AFC2WG),'' released January 1995. We describe fuel-cell commercialization for stationary power applications of phosphoric acid, molten carbonate, solid oxide, and polymer electrolyte membrane fuel cells.

Penner, S.S.; Appleby, A.J.; Baker, B.S.; Bates, J.L.; Buss, L.B.; Dollard, W.J.; Farris, P.J.; Gillis, E.A.; Gunsher, J.A.; Khandkar, A.; Krumpelt, M.; O'Sullivan, J.B.; Runte, G.; Savinell, R.F.; Selman, J.R.; Shores, D.A.; Tarman, P.

1995-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Enabling Thin Silicon Solar Cell Technology  

NLE Websites -- All DOE Office Websites (Extended Search)

Enabling Thin Silicon Solar Cell Technology Enabling Thin Silicon Solar Cell Technology Print Friday, 21 June 2013 10:49 Generic silicon solar cells showing +45, -45, and...

422

Engineering secondary cell wall deposition in plants  

loop, biofuels, cell wall, lignin, sacchari?cation, synthetic biology. Summary ... target speci?c cell types such as ?bre and pith cells. It is well

423

Fuel Cell Technologies Office: Technology Validation  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cell Technologies Office: Technology Validation to someone by E-mail Share Fuel Cell Technologies Office: Technology Validation on Facebook Tweet about Fuel Cell Technologies...

424

Hydrogen, Fuel Cells, & Infrastructure - Program Areas - Energy...  

NLE Websites -- All DOE Office Websites (Extended Search)

fuel cell Welcome> Program Areas> Program Areas Hydrogen, Fuel Cells & Infrastructure Production & Delivery | Storage | Fuel Cell R&D | Systems Integration & Analysis | Safety...

425

Photovoltaic Electrical Contacts and Cell Coatings  

Energy.gov (U.S. Department of Energy (DOE))

The outermost layers of photovoltaic (PV) cell, or solar cell, are the electrical contacts and anti-reflective coating. These layers provide essential functions to the cell's operation.

426

Fabrication and Characterization of Organic Solar Cells  

E-Print Network (OSTI)

processablepolymerphotovoltaiccellsbyself?organizationPhotodiodes, and Photovoltaic Cells. AppliedPhysicsF, Heeger AJ. Polymer Photovoltaic Cells ? Enhanced

Yengel, Emre

2010-01-01T23:59:59.000Z

427

Study: Cells Selectively Absorb Short Nanotubes  

Science Conference Proceedings (OSTI)

... cells, while shorter lengths are able to penetrate the cell interior (dark ... Eyed for uses ranging from electronic displays to fuel cells to water filtration ...

2012-10-02T23:59:59.000Z

428

Microfluidic Microbial Fuel Cells for Microstructure Interrogations  

E-Print Network (OSTI)

Sediment microbial fuel cells demonstrating marine (left)Model of hydrogen fuel cell kinetic losses including5 FutureWork 5.1 Microfluidic Microbial Fuel Cell Continued

Parra, Erika Andrea

2010-01-01T23:59:59.000Z

429

Canadian Fuel Cell Commercialization Roadmap Update: Progress...  

Open Energy Info (EERE)

Fuel Cell Commercialization Roadmap Update: Progress of Canada's Hydrogen and Fuel Cell Industry Jump to: navigation, search Name Canadian Fuel Cell Commercialization Roadmap...

430

Fuel Cell Handbook, Fifth Edition  

DOE Green Energy (OSTI)

Progress continues in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in November 1998. Uppermost, polymer electrolyte fuel cells, molten carbonate fuel cells, and solid oxide fuel cells have been demonstrated at commercial size in power plants. The previously demonstrated phosphoric acid fuel cells have entered the marketplace with more than 220 power plants delivered. Highlighting this commercial entry, the phosphoric acid power plant fleet has demonstrated 95+% availability and several units have passed 40,000 hours of operation. One unit has operated over 49,000 hours. Early expectations of very low emissions and relatively high efficiencies have been met in power plants with each type of fuel cell. Fuel flexibility has been demonstrated using natural gas, propane, landfill gas, anaerobic digester gas, military logistic fuels, and coal gas, greatly expanding market opportunities. Transportation markets worldwide have shown remarkable interest in fuel cells; nearly every major vehicle manufacturer in the U.S., Europe, and the Far East is supporting development. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultrahigh efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 8 describe the six major fuel cell types and their performance based on cell operating conditions. Alkaline and intermediate solid state fuel cells were added to this edition of the Handbook. New information indicates that manufacturers have stayed with proven cell designs, focusing instead on advancing the system surrounding the fuel cell to lower life cycle costs. Section 9, Fuel Cell Systems, has been significantly revised to characterize near-term and next-generation fuel cell power plant systems at a conceptual level of detail. Section 10 provides examples of practical fuel cell system calculations. A list of fuel cell URLs is included in the Appendix. A new index assists the reader in locating specific information quickly.

Energy and Environmental Solutions

2000-10-31T23:59:59.000Z

431

Cell Component Accelerated Stress Test Protocols for PEM Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

USCAR FUEL CELL TECH TEAM USCAR FUEL CELL TECH TEAM CELL COMPONENT ACCELERATED STRESS TEST PROTOCOLS FOR PEM FUEL CELLS (Electrocatalysts, Supports, Membranes, and Membrane Electrode Assemblies) Revised May 26, 2010 Fuel cells, especially for automotive propulsion, must operate over a wide range of operating and cyclic conditions. The desired operating range encompasses temperatures from below the freezing point to well above the boiling point of water, humidity from ambient to saturated, and half-cell potentials from 0 to >1.5 volts. Furthermore, the anode side of the cell may be exposed to hydrogen and air during different parts of the driving and startup/shutdown cycles. The severity in operating conditions is greatly exacerbated by the transient and cyclic nature of

432

Handbook of fuel cell performance  

DOE Green Energy (OSTI)

The intent of this document is to provide a description of fuel cells, their performances and operating conditions, and the relationship between fuel processors and fuel cells. This information will enable fuel cell engineers to know which fuel processing schemes are most compatible with which fuel cells and to predict the performance of a fuel cell integrated with any fuel processor. The data and estimates presented are for the phosphoric acid and molten carbonate fuel cells because they are closer to commercialization than other types of fuel cells. Performance of the cells is shown as a function of operating temperature, pressure, fuel conversion (utilization), and oxidant utilization. The effect of oxidant composition (for example, air versus O/sub 2/) as well as fuel composition is examined because fuels provided by some of the more advanced fuel processing schemes such as coal conversion will contain varying amounts of H/sub 2/, CO, CO/sub 2/, CH/sub 4/, H/sub 2/O, and sulfur and nitrogen compounds. A brief description of fuel cells and their application to industrial, commercial, and residential power generation is given. The electrochemical aspects of fuel cells are reviewed. The phosphoric acid fuel cell is discussed, including how it is affected by operating conditions; and the molten carbonate fuel cell is discussed. The equations developed will help systems engineers to evaluate the application of the phosphoric acid and molten carbonate fuel cells to commercial, utility, and industrial power generation and waste heat utilization. A detailed discussion of fuel cell efficiency, and examples of fuel cell systems are given.

Benjamin, T.G.; Camara, E.H.; Marianowski, L.G.

1980-05-01T23:59:59.000Z

433

Double interconnection fuel cell array  

DOE Patents (OSTI)

A fuel cell array (10) is made, containing number of tubular, elongated fuel cells (12) which are placed next to each other in rows (A, B, C, D), where each cell contains inner electrodes (14) and outer electrodes (18 and 18'), with solid electrolyte (16 and 16') between the electrodes, where the electrolyte and outer electrode are discontinuous, having two portions, and providing at least two opposed discontinuities which contain at least two oppositely opposed interconnections (20 and 20') contacting the inner electrode (14), each cell (12) having only three metallic felt electrical connectors (22) which contact surrounding cells, where each row is electrically connected to the other.

Draper, Robert (Churchill Boro, PA); Zymboly, Gregory E. (Murrysville, PA)

1993-01-01T23:59:59.000Z

434

IAP Antagonists Promote Cell Death  

NLE Websites -- All DOE Office Websites (Extended Search)

IAP Antagonists Promote Cell Death IAP Antagonists Promote Cell Death IAP Antagonists Promote Cell Death Print Thursday, 02 August 2012 11:19 Apoptosis, or programmed cell death, is a normal process for most cells in multicellular organisms. Inhibitor of apoptosis (IAP) proteins suppress apoptosis and are over-expressed in human cancer cells, causing resistance to cytotoxic therapies. An IAP antagonist can mitigate the anti-apoptotic functions of IAPs, spurring trials on IAP-targeting therapeutics that mimic endogenous IAP antagonists. To understand the mechanisms at work here, Genentech researchers investigated the structure of cellular IAP1 (cIAP1) BIR3-RING (B3R). When IAP antagonists bind to the BIR3 domain of cIAP1, a RING-based dimer forms, stimulating the addition of ubiquitin to the target protein substrate, thus marking it for degradation by the cell's proteasome.

435

Silicon Cells | Open Energy Information  

Open Energy Info (EERE)

Cells Cells Jump to: navigation, search Name Silicon Cells Place United Kingdom Product Technology developer based upon a low cost method of processing silicon to produce a new generation of high energy density batteries. References Silicon Cells[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Silicon Cells is a company located in United Kingdom . References ↑ "Silicon Cells" Retrieved from "http://en.openei.org/w/index.php?title=Silicon_Cells&oldid=351081" Categories: Clean Energy Organizations Companies Organizations Stubs What links here Related changes Special pages Printable version Permanent link Browse properties About us Disclaimers Energy blogs

436

Fuel Cell Technologies Office: About  

NLE Websites -- All DOE Office Websites (Extended Search)

About the Fuel Cell Technologies Office About the Fuel Cell Technologies Office The Fuel Cell Technologies Office conducts comprehensive efforts to overcome the technological, economic, and institutional barriers to the widespread commercialization of hydrogen and fuel cells. The office is aligned with the strategic vision and goals of the U.S. Department of Energy (DOE). The office's efforts will help secure U.S. leadership in clean energy technologies and advance U.S. economic competitiveness and scientific innovation. What We Do DOE is the lead federal agency for directing and integrating activities in hydrogen and fuel cell R&D as authorized in the Energy Policy Act of 2005. The Fuel Cell Technologies Office is responsible for coordinating the R&D activities for DOE's Hydrogen and Fuel Cells Program, which includes activities within four DOE offices (Office of Energy Efficiency and Renewable Energy [EERE], Office of Fossil Energy, Office of Nuclear Energy, and Office of Science).

437

Hydrogen and Fuel Cell Activities  

NLE Websites -- All DOE Office Websites (Extended Search)

8/5/2011 eere.energy.gov 8/5/2011 eere.energy.gov 5 th International Conference on Polymer Batteries & Fuel Cells Argonne, Illinois Hydrogen and Fuel Cell Activities Dr. Sunita Satyapal U.S. Department of Energy Fuel Cell Technologies Program Program Manager August 4, 2011 2 | Fuel Cell Technologies Program Source: US DOE 8/5/2011 eere.energy.gov Fuel Cells: Benefits & Market Potential The Role of Fuel Cells Key Benefits Very High Efficiency Reduced CO 2 Emissions * 35-50%+ reductions for CHP systems (>80% with biogas) * 55-90% reductions for light- duty vehicles * up to 60% (electrical) * up to 70% (electrical, hybrid fuel cell / turbine) * up to 85% (with CHP) Reduced Oil Use * >95% reduction for FCEVs (vs. today's gasoline ICEVs)

438

Fuel Cell Technologies Program Overview  

NLE Websites -- All DOE Office Websites (Extended Search)

IEA HIA Hydrogen Safety Stakeholder IEA HIA Hydrogen Safety Stakeholder Workshop Bethesda, Maryland Fuel Cell Technologies Program Overview Dr. Sunita Satyapal U.S. Department of Energy Fuel Cell Technologies Program Program Manager 10/2/2012 2 | Fuel Cell Technologies Program eere.energy.gov Overview Fuel Cells - An Emerging Global Industry Clean Energy Patent Growth Index [1] shows that fuel cell patents lead in the clean energy field with over 950 fuel cell patents issued in 2011. * Nearly double the second place holder, solar, which has ~540 patents. [1] http://cepgi.typepad.com/files/cepgi-4th-quarter-2011-1.pdf United States 46% Germany 7% Korea 7% Canada 3% Taiwan 1% Great Britain 1% France 1% Other 3% Japan 31% Fuel Cell Patents Geographic Distribution 2002-2011 Top 10 companies: GM, Honda, Samsung,

439

Iron Absorption  

NLE Websites -- All DOE Office Websites (Extended Search)

Iron Absorption Iron Absorption Name: Mary Location: N/A Country: N/A Date: N/A Question: I wrote before to Steve and got a answer back. I would like more information. The cirmcustances were that I first had anaemia and then I went for a gastroscopy. The results of which were I had insufficient acid been produced in the stomach. I was told that acid was nessary for the absorbion of iron and it was because of this that I became anaemic. I was told to eat plently of red meat not too many vegetables. Is there any other information you can give me? Replies: It is very difficult to say for sure without seeing you chart and I am not your doctor. But it sounds to me like you are deficient in the vitamin B12. In your stomach you have 3 basic types of cells. One is called chief cells which secrete the precursor of the enzyme pepsin which begins the breakdown of protein. Another is called the parietal cells which secrete your stomach acid and a substance called intrinsic factor. Now-switch to your bone marrow which is where your red blood cells are made. In order for your red blood cells to mature in the bone marrow, vitamin B12 is necessary. B12 can only be obtained from animal food sources such as meat, milk and eggs. Unfortunately, B12 cannot be absorbed in the stomach without intrinsic factor. If there is sufficient B12 present in the diet, it can be stored in the liver. If you aren't eating enough animal sources your B12 will be taken from your liver until you run out. You could also be deficient in intrinsic factor. So while the outcome is anemia (not enough red blood cells) the problem could be from a few different things. Follow your doctor's recommendations and eat more sources of B12

440

Quantifying Cell-to-Cell Variations in Lithium Ion Batteries  

DOE Green Energy (OSTI)

Lithium ion batteries have conventionally been manufactured in small capacities but large volumes for consumer electronics applications. More recently, the industry has seen a surge in the individual cell capacities, as well as the number of cells used to build modules and packs. Reducing cell-to-cell and lot-to-lot variations has been identified as one of the major means to reduce the rejection rate when building the packs as well as to improve pack durability. The tight quality control measures have been passed on from the pack manufactures to the companies building the individual cells and in turn to the components. This paper identifies a quantitative procedure utilizing impedance spectroscopy, a commonly used tool, to determine the effects of material variability on the cell performance, to compare the relative importance of uncertainties in the component properties, and to suggest a rational procedure to set quality control specifications for the various components of a cell, that will reduce cell-to-cell variability, while preventing undue requirements on uniformity that often result in excessive cost of manufacturing but have a limited impact on the cells performance.

Santhanagopalan, S.; White, R. E.

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Photovoltaic Cell Basics | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

Cell Basics Photovoltaic Cell Basics August 16, 2013 - 4:53pm Addthis Photovoltaic (PV) cells, or solar cells, take advantage of the photoelectric effect to produce electricity. PV...

442

Point-Contact Silicon Solar Cells  

Science Conference Proceedings (OSTI)

A new type of silicon photovoltaic cell called the point-contact cell is under development. This report describes the cell and an analytic model developed for use in design optimization. Necessary future cell development work is discussed.

1983-05-01T23:59:59.000Z

443

Monolithic tandem solar cell  

DOE Patents (OSTI)

A single-crystal, monolithic, tandem, photovoltaic solar cell is described which includes (a) an InP substrate having upper and lower surfaces, (b) a first photoactive subcell on the upper surface of the InP substrate, (c) a second photoactive subcell on the first subcell; and (d) an optically transparent prismatic cover layer over the second subcell. The first photoactive subcell is GaInAsP of defined composition. The second subcell is InP. The two subcells are lattice matched. 9 figs.

Wanlass, M.W.

1994-06-21T23:59:59.000Z

444

Monolithic tandem solar cell  

DOE Patents (OSTI)

A single-crystal, monolithic, tandem, photovoltaic solar cell is described which includes (a) an InP substrate having upper and lower surfaces, (b) a first photoactive subcell on the upper surface of the InP substrate, (c) a second photoactive subcell on the first subcell; and (d) an optically transparent prismatic cover layer over the second subcell. The first photoactive subcell is GaInAsP of defined composition. The second subcell is InP. The two subcells are lattice matched.

Wanlass, Mark W. (Golden, CO)

1994-01-01T23:59:59.000Z

445

Some Statistical Techniques for Comparing Cell Colonies ...  

Science Conference Proceedings (OSTI)

... Using fluorescence microscopy, cell shapes can be imaged. A population of identical cells exhibits a distribution of shape responses. ...

2010-09-08T23:59:59.000Z

446

Computational Biology: Comparison of Cell Image ...  

Science Conference Proceedings (OSTI)

... The cells were image by fluorescent microscopy. ... The image data was processed to differentiate between the 2 cell lines. ...

2012-07-10T23:59:59.000Z

447

Laboratory Equipment - Milipore Stirred Ultrafiltration Cell  

Science Conference Proceedings (OSTI)

Milipore Stirred Ultrafiltration Cell. Description: Location: E136. Specifications / Capabilities: Stirred Cell, Model 8003, Model 8010, Model 8050. ...

2012-10-31T23:59:59.000Z

448

Molecular Cell, Volume 50 Supplemental Information  

E-Print Network (OSTI)

by growing the cells for five days in the presence of 10 ug/ml of Doxycycline. For immunoprecipitation, cells

Ares Jr., Manny

449

NREL: Hydrogen and Fuel Cells Research - National Fuel Cell Technology  

NLE Websites -- All DOE Office Websites (Extended Search)

National Fuel Cell Technology Evaluation Center National Fuel Cell Technology Evaluation Center The National Fuel Cell Technology Evaluation Center (NFCTEC) at NREL's Energy Systems Integration Facility (ESIF) plays a crucial role in NREL's independent, third-party analysis of hydrogen fuel cell technologies in real-world operation. The NFCTEC is designed for secure management, storage, and processing of proprietary data from industry. Access to the off-network NFCTEC is limited to NREL's Technology Validation Team, which analyzes detailed data and reports on fuel cell technology status, progress, and technical challenges. Graphic representing NREL's Hydrogen Secure Data Center and the variety of applications from which it gathers data, including fuel cell (FC) stacks, FC backup power, FC forklifts, FC cars, FC buses, and FC prime power, and hydrogen infrastructure.

450

Transitioning from Fuel Cells to Redox Flow Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Transitioning From Fuel Cells to Redox Transitioning From Fuel Cells to Redox Flow Cells T. Zawodzinski and Matt Mench University of Tennessee and ORNL Managed by UT-Battelle for the Department of Energy 2 Acknowledgments $$ DOE-OE EPRI GCEP NSF EPSCOR (TN SCORE) UTK Governor's Chair Fund Partner in Crime Matt Mench Managed by UT-Battelle for the Department of Energy 'Peeling the Onion' Personalized History of PEM Fuel Cells We May Recapitulate This for RFBs Catalysis Test System * Small Single Cell * Large Single Cell * Stack * System Layers of the Onion Hot Topic du Jour * Water Management, Membranes * Late '80's, early '90's * Reformate Tolerance, DMFC's * Mid '90's * High Temp Membranes * Late '90's * Durability * Early '00's Modeling * Membrane/ Water * Cathode * Impedance

451

Inappropriate Use of Cell Phones  

E-Print Network (OSTI)

School counselors face the ongoing complexity of trying to inform students and educators about the appropriate use of cell phones at school. With almost 75 percent of all school age students having cell phones, the use of them in and outside of school is increasing. Situations regarding the misuse of cell phones continue to appear in the news, as part of school sexting scandals, and also harassment to the point of suicides by students are examples of how students have misused cell phones and the internet to intimidate and bully to the point of death. This literature review examined the different ways in which students use cell phones and ultimately the implications this use has for students. Cell phone history and their technological state of affairs, as well as moral, ethical and legal complications of the inappropriate use of cell phones, students misuse of cell phones, students misuse of the internet on phones regarding3 School related tasks, and the implications that inappropriate use of cell phones has on students are included. The review concludes with suggestions and recommendations for practitioners in the field of school counseling to help inform, intervene, and prevent the inappropriate use of cell phones by students. 4

Jami Mcauley; Jami L

2011-01-01T23:59:59.000Z

452

EE580 Solar Cells Todd J. Kaiser  

E-Print Network (OSTI)

7/21/2010 1 EE580 ­ Solar Cells Todd J. Kaiser · Lecture 08 · Solar Cell Characterization 1Montana State University: Solar Cells Lecture 8: Characterization Solar Cell Operation n Emitter p Base Rear completing the circuit 2Montana State University: Solar Cells Lecture 8: Characterization Solar Cell

Kaiser, Todd J.

453

Ion cyclotron resonance cell  

DOE Patents (OSTI)

An ion cyclotron resonance cell is disclosed having two adjacent sections separated by a center trapping plate. The first section is defined by the center trapping plate, a first end trapping plate, and excitation and detector electrodes. The second section includes a second end trapping plate spaced apart from the center plate, a mirror, and an analyzer. The analyzer includes a wavelength-selective light detector, such as a detector incorporating an acousto-optical device (AOD) and a photodetector. One or more ion guides, grounded plates with holes for the ion beam, are positioned within the vacuum chamber of the mass spectrometer between the ion source and the cell. After ions are trapped and analyzed by ion cyclotron resonance techniques in the first section, the ions of interest are selected according to their mass and passed into the second section for optical spectroscopic studies. The trapped ions are excited by light from a laser and caused thereby to fluoresce. The fluorescent light emitted by the excited ions is reflected by the mirror and directed onto the detector. The AOD is scanned, and the photodetector output is recorded and analyzed. The ions remain in the second section for an extended period, enabling multiple studies to be carried out on the same ensemble of ions. 5 figs.

Weller, R.R.

1995-02-14T23:59:59.000Z

454

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

Multi-Year Research, Development and Demonstration Plan* The Fuel Cell Technologies Office Multi-Year Research, Development, and Demonstration (MYRD&D) Plan* describes the goals,...

455

NREL: Hydrogen and Fuel Cells Research - Fuel Cell Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

with a focus on improving the performance and durability and reducing the cost of fuel cell components and systems. Research efforts involve: Developing advanced catalysts,...

456

Biomass Fuel Cell Systems - DOE Hydrogen and Fuel Cells Program...  

NLE Websites -- All DOE Office Websites (Extended Search)

Utilize ceramic microchannel reactor technology for * reforming of natural gas and biogas fuels for subsequent electrochemical oxidation within a solid-oxide fuel cell (SOFC)....

457

DOE Hydrogen and Fuel Cells Program: Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

portable power and auxiliary power applications in a limited fashion where earlier market entry would assist in the development of a fuel cell manufacturing base. This DOE...

458

Fuel Cell Technologies Office: Alkaline Membrane Fuel Cell Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Renewable Energy Laboratory Anion Exchange Membranes for Fuel Cells, Prof. Andrew Herring, Colorado School of Mines Electrocatalysis in Alkaline Electrolytes, Prof. Sanjeev...

459

NREL: Hydrogen and Fuel Cells Research - Fuel Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

high conductivity) for this application include tin oxide, indium tin oxide, and zinc oxide. Contact: Bryan Pivovar 303-275-3809 Printable Version Hydrogen & Fuel Cells Research...

460

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

Newsletter: August 2013 The August 2013 issue of the Fuel Cell Technologies Office newsletter includes stories in these categories: In the News Funding Opportunities Webinars and...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Fuel Cell Technologies Office: Fuel Cell Technologies Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

hydrogen and fuel cells. This information is provided in documents such as technical and project reports, conference proceedings and journal articles, technical presentations, and...

462

Fuel Cell Technologies Office: Fuel Cells for Portable Power...  

NLE Websites -- All DOE Office Websites (Extended Search)

Session - Fuel Cell Portable Power Perspectives End User Perspective - Industry Consumer Electronics Power (PDF 1.51 MB) Jerry Hallmark, Motorola Portable Power Sources (above...

463

Flexible method for monitoring fuel cell voltage  

DOE Patents (OSTI)

A method for equalizing the measured voltage of each cluster in a fuel cell stack wherein at least one of the clusters has a different number of cells than the identical number of cells in the remaining clusters by creating a pseudo voltage for the different cell numbered cluster. The average cell voltage of the all of the cells in the fuel cell stack is calculated and multiplied by a constant equal to the difference in the number of cells in the identical cell clusters and the number of cells in the different numbered cell cluster. The resultant product is added to the actual voltage measured across the different numbered cell cluster to create a pseudo voltage which is equivalent in cell number to the number of cells in the other identical numbered cell clusters.

Mowery, Kenneth D. (Noblesville, IN); Ripley, Eugene V. (Russiaville, IN)

2002-01-01T23:59:59.000Z

464

fuel cells | OpenEI  

Open Energy Info (EERE)

cells cells Dataset Summary Description Developed for the U.S. Department of Energy's Office of Fuel Cell Technologies by Argonne National Laboratory and RCF Economic and Financial Consulting, Inc., JOBS and economic impacts of Fuel Cells (JOBS FC) is a spreadsheet model that estimates economic impacts from the manufacture and use of select types of fuel cells. Source Argonne Date Released Unknown Date Updated Unknown Keywords fuel cells Job Creation Data application/vnd.openxmlformats-officedocument.spreadsheetml.sheet icon File without Macros. Full version at official link. (xlsx, 2.8 MiB) Quality Metrics Level of Review Some Review Comment Temporal and Spatial Coverage Frequency Time Period License License Open Data Commons Attribution License Comment From Argonne National Lab

465

Silicon concentrator solar cell research  

DOE Green Energy (OSTI)

This report describes work conducted between December 1990 and May 1992 continuing research on silicon concentrator solar cells. The objectives of the work were to improve the performance of high-efficiency cells upon p-type substrates, to investigate the ultraviolet stability of such cells, to develop concentrator cells based on n-type substrates, and to transfer technology to appropriate commercial environments. Key results include the identification of contact resistance between boron-defused areas and rear aluminum as the source of anomalously large series resistance in both p- and n-type cells. A major achievement of the present project was the successful transfer of cell technology to both Applied Solar Energy Corporation and Solarex Corporation.

Green, M.A.; Zhao, J.; Wang, A.; Dai, X.; Milne, A.; Cai, S.; Aberle, A.; Wenham, S.R. [Univ. of New South Wales, Kensington, NSW (AU). Centre for Photovoltaic Devices and Systems

1993-06-01T23:59:59.000Z

466

Corrugated Membrane Fuel Cell Structures  

DOE Green Energy (OSTI)

By corrugating the fuel cell membrane electrode structure, Ion Power?s goal is to realize both the Pt utilization targets as well as the power density targets of the DOE. This will be achieved by demonstrating a fuel cell single cell (50 cm2) with a twofold increase in the membrane active area over the geometric area of the cell by corrugating the MEA structure. The corrugating structure must be able to demonstrate the target properties of < 10 mOhm-cm2 electrical resistance at > 20 psi compressive strength over the active area, in combination with offering at least 80% of power density that can be achieved by using the same MEA in a flat plate structure. Corrugated membrane fuel cell structures also have the potential to meet DOE power density targets by essentially packaging more membrane area into the same fuel cell volume as compared to conventional stack constructions.

Grot, Stephen [President, Ion Power Inc.

2013-09-30T23:59:59.000Z

467

Hybrid Fuel Cell Technology Overview  

SciTech Connect

For the purpose of this STI product and unless otherwise stated, hybrid fuel cell systems are power generation systems in which a high temperature fuel cell is combined with another power generating technology. The resulting system exhibits a synergism in which the combination performs with an efficiency far greater than can be provided by either system alone. Hybrid fuel cell designs under development include fuel cell with gas turbine, fuel cell with reciprocating (piston) engine, and designs that combine different fuel cell technologies. Hybrid systems have been extensively analyzed and studied over the past five years by the Department of Energy (DOE), industry, and others. These efforts have revealed that this combination is capable of providing remarkably high efficiencies. This attribute, combined with an inherent low level of pollutant emission, suggests that hybrid systems are likely to serve as the next generation of advanced power generation systems.

None available

2001-05-31T23:59:59.000Z

468

Solar cell module lamination process  

DOE Patents (OSTI)

A solar cell module lamination process using fluoropolymers to provide protection from adverse environmental conditions and thus enable more extended use of solar cells, particularly in space applications. A laminate of fluoropolymer material provides a hermetically sealed solar cell module structure that is flexible and very durable. The laminate is virtually chemically inert, highly transmissive in the visible spectrum, dimensionally stable at temperatures up to about 200.degree. C. highly abrasion resistant, and exhibits very little ultra-violet degradation.

Carey, Paul G. (Mountain View, CA); Thompson, Jesse B. (Brentwood, CA); Aceves, Randy C. (Tracy, CA)

2002-01-01T23:59:59.000Z

469

Fuel cell gas management system  

SciTech Connect

A fuel cell gas management system including a cathode humidification system for transferring latent and sensible heat from an exhaust stream to the cathode inlet stream of the fuel cell; an anode humidity retention system for maintaining the total enthalpy of the anode stream exiting the fuel cell equal to the total enthalpy of the anode inlet stream; and a cooling water management system having segregated deionized water and cooling water loops interconnected by means of a brazed plate heat exchanger.

DuBose, Ronald Arthur (Marietta, GA)

2000-01-11T23:59:59.000Z

470

Improved electrolytes for fuel cells  

DOE Green Energy (OSTI)

Present day fuel cells based upon hydrogen and oxygen have limited performance due to the use of phosphoric acid as an electrolyte. Improved performance is desirable in electrolyte conductivity, electrolyte management, oxygen solubility, and the kinetics of the reduction of oxygen. Attention has turned to fluorosulfonic acids as additives or substitute electrolytes to improve fuel cell performance. The purpose of this project is to synthesize and electrochemically evaluate new fluorosulfonic acids as superior alternatives to phosphoric acid in fuel cells. (VC)

Gard, G.L.; Roe, D.K.

1991-06-01T23:59:59.000Z

471

Molten carbonate fuel cell separator  

DOE Patents (OSTI)

In a stacked array of molten carbonate fuel cells, a fuel cell separator is positioned between adjacent fuel cells to provide isolation as well as a conductive path therebetween. The center portion of the fuel cell separator includes a generally rectangular, flat, electrical conductor. Around the periphery of the flat portion of the separator are positioned a plurality of elongated resilient flanges which form a gas-tight seal around the edges of the fuel cell. With one elongated flange resiliently engaging a respective edge of the center portion of the separator, the sealing flanges, which are preferably comprised of a noncorrosive material such as an alloy of yttrium, iron, aluminum or chromium, form a tight-fitting wet seal for confining the corrosive elements of the fuel cell therein. This arrangement permits a good conductive material which may be highly subject to corrosion and dissolution to be used in combination with a corrosion-resistant material in the fuel cell separator of a molten carbonate fuel cell for improved fuel cell conductivity and a gas-tight wet seal.

Nickols, Richard C. (East Hartford, CT)

1986-09-02T23:59:59.000Z

472

Molten carbonate fuel cell separator  

DOE Patents (OSTI)

In a stacked array of molten carbonate fuel cells, a fuel cell separator is positioned between adjacent fuel cells to provide isolation as well as a conductive path therebetween. The center portion of the fuel cell separator includes a generally rectangular, flat, electrical conductor. Around the periphery of the flat portion of the separator are positioned a plurality of elongated resilient flanges which form a gas-tight seal around the edges of the fuel cell. With one elongated flange resiliently engaging a respective edge of the center portion of the separator, the sealing flanges, which are preferably comprised of a noncorrosive material such as an alloy of yttrium, iron, aluminum or chromium, form a tight-fitting wet seal for confining the corrosive elements of the fuel cell therein. This arrangement permits a good conductive material which may be highly subject to corrosion and dissolution to be used in combination with a corrosion-resistant material in the fuel cell separator of a molten carbonate fuel cell for improved fuel cell conductivity and a gas-tight wet seal.

Nickols, R.C.

1984-10-17T23:59:59.000Z

473

Thermal Management of Solar Cells.  

E-Print Network (OSTI)

??The focus on solar cells as a source of photovoltaic energy is rapidly increasing nowadays. The amount of sun's energy entering earth surface in one (more)

Saadah, Mohammed Ahmed

2013-01-01T23:59:59.000Z

474

LADWP FUEL CELL DEMONSTRATION PROJECT  

SciTech Connect

Los Angeles Department of Water and Power (LADWP) is currently one of the most active power utility companies in researching fuel cell technology. Fuel cells offer many benefits and are now used as an alternative to traditional internal combustion engines in power generation. In continuing it's role as the leader in fuel cell research, LADWP has installed a pre-commercial molten carbonate fuel cell on August 2001 at its headquarter, the John Ferraro Building (JFB). The goal of this project is to learn more about the actual behavior of the fuel cell running under real world conditions. The fuel cell ran smoothly through the first year of operation with very high efficiency, but with some minor setbacks. The JFB fuel cell project is funded by the City of Los Angeles Department of Water and Power with partial grant funding from the Department of Defense's Climate Change Fuel Cell Buydown Program. The technical evaluation and the benefit-cost evaluation of the JFB fuel cell are both examined in this report.

Thai Ta

2003-09-12T23:59:59.000Z

475

Fuel Cells | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

as high as 90% is achievable. This high efficiency operation saves money, saves energy, and reduces greenhouse gas emissions. Regenerative or Reversible Fuel Cells This...

476

Fuel Cell Technologies Office: About  

NLE Websites -- All DOE Office Websites (Extended Search)

variety of other fuels, including natural gas and renewable fuels such as methanol or biogas. Hydrogen and fuel cells can provide these benefits and address critical challenges in...

477

Multi-cell storage battery  

DOE Patents (OSTI)

A multi-cell storage battery, in particular to a lithium storage battery, which contains a temperature control device and in which groups of one or more individual cells arranged alongside one another are separated from one another by a thermally insulating solid layer whose coefficient of thermal conductivity lies between 0.01 and 0.2 W/(m*K), the thermal resistance of the solid layer being greater by at least a factor .lambda. than the thermal resistance of the individual cell. The individual cell is connected, at least in a region free of insulating material, to a heat exchanger, the thermal resistance of the heat exchanger in the direction toward the neighboring cell being selected to be greater by at least a factor .lambda. than the thermal resistance of the individual cell and, in addition, the thermal resistance of the heat exchanger toward the temperature control medium being selected to be smaller by at least a factor of about 10 than the thermal resistance of the individual cell, and .lambda. being the ratio of the energy content of the individual cell to the amount of energy that is needed to trigger a thermally induced cell failure at a defined upper operating temperature limit.

Brohm, Thomas (Hattersheim, DE); Bottcher, Friedhelm (Kelkheim, DE)

2000-01-01T23:59:59.000Z

478

CLIMATE CHANGE FUEL CELL PROGRAM  

DOE Green Energy (OSTI)

This report discusses the first year of operation of a fuel cell power plant located at the Sheraton Edison Hotel, Edison, New Jersey. PPL EnergyPlus, LLC installed the plant under a contract with the Starwood Hotels & Resorts Worldwide, Inc. A DFC{reg_sign}300 fuel cell, manufactured by FuelCell Energy, Inc. of Danbury, CT was selected for the project. The fuel cell successfully operated from June 2003 to May 2004. This report discusses the performance of the plant during this period.

Steven A. Gabrielle

2004-12-03T23:59:59.000Z

479

Quantitative Imaging in Cell Biology  

E-Print Network (OSTI)

Quantitative! imaging! in! biology! is! concerned! with!Quantitative! imaging! in! biology! is! concerned! with!advances! in! cell! biology! by! enabling! the! tracking!

Yassif, Jaime

2012-01-01T23:59:59.000Z

480

Cytometric Therapies for Cell Delivery  

Stem cell therapies are a viable treatment options for some human diseases. Efficacy of such therapies can be maximized by addressing critical issues ...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Energy Basics: Fuel Cell Vehicles  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

& Fuels Printable Version Share this resource Fuels Vehicles Electric Vehicles Flexible Fuel Vehicles Fuel Cell Vehicles Hybrid Electric Vehicles Natural Gas Vehicles Propane...

482

Fuel Cell Technologies Office: Education  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

& Offices | Consumer Information Education Search Search Help Education EERE Fuel Cell Technologies Office Education Printable Version Share this resource Send a link...

483

Quantum Dot Solar Cells: Preprint  

DOE Green Energy (OSTI)

Presented at the 2001 NCPV Program Review Meeting: Potential of quantum dot solar cells to increase the maximum attainable thermodynamic conversion efficiency of solar photoconversion to about 66%.

Nozik, A. J.

2001-10-01T23:59:59.000Z

484

EERE Fuel Cell Technologies Program  

NLE Websites -- All DOE Office Websites (Extended Search)

Results will be documented in a report by Pacific Northwest National Lab: "Pathways to Commercial Success: Technologies and Products Supported by the Hydrogen, Fuel Cells and...

485

Energy Basics: Photovoltaic Cell Performance  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Performance Photovoltaic (PV), or solar cells use the energy in sunlight to produce electricity. However, the amount of electricity produced depends on the quality of the light...

486

TUTORIALS: Solar Cell Operation - TMS  

Science Conference Proceedings (OSTI)

Jan 21, 2008 ... This animated tutorial describes the basics of solar cell operation. It defines the photovoltaic effect, discusses electron and current flow within a...

487

Bulb mounting of solar cell  

SciTech Connect

An energy converting assembly is provided for parasiting of light from a fluorescent light bulb utilizing a solar cell. The solar cell is mounted on a base member elongated in the dimension of elongation of the fluorescent bulb, and electrical interconnections to the cell are provided. A flexible sheet of opaque material having a flat white interior reflective surface surrounds the fluorescent bulb and reflects light emitted from the bulb back toward the bulb and the solar cell. The reflective sheet is tightly held in contact with the bottom of the bulb by adhesive, a tie strap, an external clip, or the like.

Thompson, M.E.

1983-04-05T23:59:59.000Z

488

ELECTRON-VOLTAIC CELL STUDY  

SciTech Connect

The properties of Si, GaAs, Ge, and possible beta sources were considered, together with radiation damage to the three materials. Additionally, the characteristics of p-n junction cells under beta activity were derived, and the characteristics of GaAs and Si cells were obtained experimentally. The results indicate that a nuclear battery using GaAs or n-p Si cells with Pm/sup 147/ as the source would operate for 5 to 10 yr with very little radiation damage. Cell characteristics for a given source activity were calculated. 66 references. (D.C.W.)

Robison, W.C.; Nelson, M.D.

1963-01-01T23:59:59.000Z

489

Hawaii Fuel Cell Test Facility  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cell Test Facility presented to DOE Hydrogen Codes and Standards Coordinating Committee Fuel Purity Specifications Workshop Renaissance Hollywood Hotel by Rick Rocheleau...

490

An advanced fuel cell simulator  

E-Print Network (OSTI)

Fuel cell power generation systems provide a clean alternative to the conventional fossil fuel based systems. Fuel cell systems have a high e?ciency and use easily available hydrocarbons like methane. Moreover, since the by-product is water, they have a very low environmental impact. The fuel cell system consists of several subsystems requiring a lot of e?ort from engineers in diverse areas. Fuel cell simulators can provide a convenient and economic alternative for testing the electrical subsystems such as converters and inverters. This thesis proposes a low-cost and an easy-to-use fuel cell simulator using a programmable DC supply along with a control module written in LabVIEW. This simulator reproduces the electrical characteristics of a 5kW solid oxide fuel cell (SOFC) stack under various operating conditions. The experimental results indicate that the proposed simulator closely matches the voltage-current characteristic of the SOFC system under varying load conditions. E?ects of non-electrical parameters like hydrogen ?ow rate are also modeled and these parameters are taken as dynamic inputs from the user. The simulator is customizable through a graphical user interface and allows the user to model other types of fuel cells with the respective voltage-current data. The simulator provides an inexpensive and accurate representation of a solid oxide fuel cell under steady state and transient conditions and can replace an actual fuel cell during testing of power conditioning equipment.

Acharya, Prabha Ramchandra

2004-08-01T23:59:59.000Z

491

LADWP FUEL CELL DEMONSTRATION PROJECT  

DOE Green Energy (OSTI)

Los Angeles Department of Water and Power (LADWP) is currently one of the most active power utility companies in researching fuel cell technology. Fuel cells offer many benefits and are now used as an alternative to traditional internal combustion engines in power generation. In continuing it's role as the leader in fuel cell research, LADWP has installed a pre-commercial molten carbonate fuel cell on August 2001 at its headquarter, the John Ferraro Building (JFB). The goal of this project is to learn more about the actual behavior of the fuel cell running under real world conditions. The fuel cell ran smoothly through the first year of operation with very high efficiency, but with some minor setbacks. The JFB fuel cell project is funded by the City of Los Angeles Department of Water and Power with partial grant funding from the Department of Defense's Climate Change Fuel Cell Buydown Program. The technical evaluation and the benefit-cost evaluation of the JFB fuel cell are both examined in this report.

Thai Ta

2003-09-12T23:59:59.000Z

492

Mitochondrial Distribution in Mammalian Cells.  

E-Print Network (OSTI)

??The mitochondrion is an important and essential cell organelle which provides about 90% energy for the organism and plays a number of important roles in (more)

Jiang, Lei

2009-01-01T23:59:59.000Z

493

Fuel Cell Technologies Office: Education  

NLE Websites -- All DOE Office Websites (Extended Search)

Fuel Cell Technologies Office - Education Students learn about solar energy. DOE supports demonstrations and commercialization by providing technically accurate and objective...

494

Test Cell Location  

NLE Websites -- All DOE Office Websites (Extended Search)

Mazda 3 i-Stop Mazda 3 i-Stop Test Cell Location APRF- 4WD Vehicle Setup Information Downloadable Dynamometer Database (D 3 )- Test Summary Sheet Vehicle Architecture Conventional- Start Stop Vehicle Dynamometer Input Document Date 11/20/2012 Advanced Powertrain Research Facility Test weight [lb] 3250 Vehicle Dynamometer Input Document Date 11/20/2012 Revision Number 1 Advanced Powertrain Research Facility Test weight [lb] Target A [lb] 3250 31.2 Target B [lb/mph] Target C [lb/mph^2] 0.462 0.014 Test Fuel Information - Vehicle equipped with with i-Stop package - Manual Transmission - All tests completed in ECO mode - EPA shift schedule modified based on vehicle shift light activity Revision Number 1 Notes: Fuel type EPA Tier II EEE Gasoline Test Fuel Information - Vehicle equipped with with i-Stop package

495

Photovoltaic cell assembly  

DOE Patents (OSTI)

A photovoltaic assembly for converting high intensity solar radiation into lectrical energy in which a solar cell is separated from a heat sink by a thin layer of a composite material which has excellent dielectric properties and good thermal conductivity. This composite material is a thin film of porous Al.sub.2 O.sub.3 in which the pores have been substantially filled with an electrophoretically-deposited layer of a styrene-acrylate resin. This composite provides electrical breakdown strengths greater than that of a layer consisting essentially of Al.sub.2 O.sub.3 and has a higher thermal conductivity than a layer of styrene-acrylate alone.

Beavis, Leonard C. (Albuquerque, NM); Panitz, Janda K. G. (Edgewood, NM); Sharp, Donald J. (Albuquerque, NM)

1990-01-01T23:59:59.000Z

496

Photovoltaic cell assembly  

DOE Patents (OSTI)

A photovoltaic assembly for converting high intensity solar radiation into electrical energy in which a solar cell is separated from a heat sink by a thin layer of a composite material which has excellent dielectric properties