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1

Bone marrow stromal cells increase oligodendrogenesis after stroke  

E-Print Network [OSTI]

Bone marrow stromal cells increase oligodendrogenesis after stroke Jing Zhang1 , Yi Li1 , Zheng cell (BMSC) treatment of stroke in rats. Rats were subjected to the middle cerebral artery occlusion (MCAo). BMSCs have been shown to promote functional recovery post stroke. A therapeutic dose of BMSC (3

Cai, Long

2

Transatlantic Bone Marrow Transplantation  

Science Journals Connector (OSTI)

The Ontario Cancer Institute/ Princess Margaret Hospital, Bone Marrow Transplant and Leukemia Service, Toronto, Canada, Dr. J. H. Lipton, asked our new HLA-DNA typing laboratory at University Hospital in Olomo...

M. Bencová; J. Benca

1997-01-01T23:59:59.000Z

3

Phenotypic Characteristics of Cell Lines Derived from Disseminated Cancer Cells in Bone Marrow of Patients with Solid Epithelial Tumors: Establishment of Working Models for Human Micrometastases  

Science Journals Connector (OSTI)

...serum deprivation. Exp. Cell Res., 224: 208-213, 1996. 59 Van der Velde-Zimmermann D., Verdaasdonk M. A., Rademakers L. H., De Weger R. A., Van den Tweel J. G., Jogling P. Fibronectin distribution in human bone marrow stroma: matrix...

Elmar Putz; Klaus Witter; Sonja Offner; Peter Stosiek; Alfred Zippelius; Judith Johnson; Robert Zahn; Gert Riethmüller; Klaus Pantel

1999-01-01T23:59:59.000Z

4

Studies of allogeneic bone marrow and spleen cell transplantation in a murine model using ultraviolet-B light  

SciTech Connect (OSTI)

Ultraviolet irradiation inhibits alloreactive and mitogen-induced responses and might reduce both graft-versus-host and host-versus-graft reactions after bone marrow transplantation (BMT). We have studied proliferative responses to mitogens and reactivity in mixed lymphocyte culture after irradiation with ultraviolet (UV)-B light using splenocytes from Balb/c (H-2d) and CBA (H-2k) mice. Response to mitogens and in MLC was strongly inhibited by 20 J/m{sup 2} and abolished at 50 J/m{sup 2}. Clonogenic cell recovery (CFU-GM; CFU-S) after UV-B irradiation was also reduced. When bone marrow and spleen cells were transplanted from parent (Balb/c) animals into F1 hybrid (Balb/c X CBA) recipients, all animals died with features indicative of graft-versus-host disease (GVHD) in 34 days. If the grafts were first irradiated with 100 J/m{sup 2} of UV-B at a mean wavelength of 310 nm, then 76% survived to day 80 when they were killed and shown to have normal marrow cellularity. The remainder died in marrow aplasia or of GVHD. H-2 typing in a group of surviving recipients showed either donor hematopoiesis only (8 of 15), mixed allogeneic chimerism (5 of 15), or recipient type hematopoiesis (2 of 15). Higher doses (200 to 300 J/m{sup 2}) were detrimental to survival with 88% of recipients dying in marrow aplasia. Syngeneic BMT in Balb/c mice showed slower hematopoietic reconstitution when the grafts were first irradiated with 100 J/m{sup 2}. After BMT from Balb/c to CBA mice all recipients of unirradiated grafts died within 54 days. By contrast, after graft irradiation with 100 J/m{sup 2} survival of recipient animals to day 80 was 59%. If these grafts were treated with 50 J/m{sup 2} survival was only 26% with an increase in deaths due to GVHD. Hematopoiesis at day 80 in a group of survivors studied by Ig heavy chain allotyping indicated donor type hematopoiesis in 6 of 10 (50 J/m{sup 2}) and 2 of 9 (100 J/m{sup 2}).

Pamphilon, D.H.; Alnaqdy, A.A.; Godwin, V.; Preece, A.W.; Wallington, T.B. (South Western Regional Transfusion Centre, Bristol (United Kingdom))

1991-05-01T23:59:59.000Z

5

Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite-bioactive ceramics  

Science Journals Connector (OSTI)

In the present study, the effects of a calcium magnesium silicate bioactive ceramic (akermanite) on proliferation and osteoblastic differentiation of human bone marrow stromal cells (hBMSC) have been investigated and compared with the classical ceramic (?-tricalcium phosphate, ?-TCP). Akermanite and ?-TCP disks were seeded with hBMSC and kept in growth medium or osteogenic medium for 10 days. Proliferation and osteoblastic differentiation were evaluated on day 1, 4, 7 and 10. The data from the Alamar Blue assay and lactic acid production assay showed that hBMSC proliferated more significantly on akermanite than on ?-TCP. The analysis of osteoblast-related genes, including alkaline phosphatase (ALP), osteopontin (OPN), bone sialoprotein (BSP) and osteocalcin (OC), indicated that akermanite ceramics enhanced the expression of osteoblast-related genes, but type I collagen (COL I) showed no noticeable difference among akermanite and ?-TCP ceramics. Furthermore, this stimulatory effect was observed not only in osteogenic medium, but also in normal growth medium without osteogenic reagents such as l-ascorbic acid, glycerophosphate and dexamethasone. This result suggests that akermanite can promote osteoblastic differentiation of hBMSC in vitro even without osteogenic reagents, and may be used as a bioactive material for bone regeneration and tissue engineering applications.

Hongli Sun; Chengtie Wu; Kerong Dai; Jiang Chang; Tingting Tang

2006-01-01T23:59:59.000Z

6

Molecular signature and in vivo behavior of bone marrow endosteal and subendosteal stromal cell populations and their relevance to hematopoiesis  

SciTech Connect (OSTI)

In the bone marrow cavity, hematopoietic stem cells (HSC) have been shown to reside in the endosteal and subendosteal perivascular niches, which play specific roles on HSC maintenance. Although cells with long-term ability to reconstitute full hematopoietic system can be isolated from both niches, several data support a heterogenous distribution regarding the cycling behavior of HSC. Whether this distinct behavior depends upon the role played by the stromal populations which distinctly create these two niches is a question that remains open. In the present report, we used our previously described in vivo assay to demonstrate that endosteal and subendosteal stromal populations are very distinct regarding skeletal lineage differentiation potential. This was further supported by a microarray-based analysis, which also demonstrated that these two stromal populations play distinct, albeit complementary, roles in HSC niche. Both stromal populations were preferentially isolated from the trabecular region and behave distinctly in vitro, as previously reported. Even though these two niches are organized in a very close range, in vivo assays and molecular analyses allowed us to identify endosteal stroma (F-OST) cells as fully committed osteoblasts and subendosteal stroma (F-RET) cells as uncommitted mesenchymal cells mainly represented by perivascular reticular cells expressing high levels of chemokine ligand, CXCL12. Interestingly, a number of cytokines and growth factors including interleukin-6 (IL-6), IL-7, IL-15, Hepatocyte growth factor (HGF) and stem cell factor (SCF) matrix metalloproteases (MMPs) were also found to be differentially expressed by F-OST and F-RET cells. Further microarray analyses indicated important mechanisms used by the two stromal compartments in order to create and coordinate the 'quiescent' and 'proliferative' niches in which hematopoietic stem cells and progenitors reside.

Balduino, Alex, E-mail: balduino@uva.edu.br [School of Dentistry, Veiga de Almeida University, Rio de Janeiro, RJ (Brazil)] [School of Dentistry, Veiga de Almeida University, Rio de Janeiro, RJ (Brazil); Mello-Coelho, Valeria [Biomedical Science Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ (Brazil) [Biomedical Science Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ (Brazil); National Institute on Aging, National Institute of Health, Baltimore, MD (United States); Wang, Zhou; Taichman, Russell S.; Krebsbach, Paul H. [Department of Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI (United States)] [Department of Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI (United States); Weeraratna, Ashani T.; Becker, Kevin G. [National Institute on Aging, National Institute of Health, Baltimore, MD (United States)] [National Institute on Aging, National Institute of Health, Baltimore, MD (United States); Mello, Wallace de [Instituto Oswaldo Cruz, Rio de Janeiro, RJ (Brazil)] [Instituto Oswaldo Cruz, Rio de Janeiro, RJ (Brazil); Taub, Dennis D. [National Institute on Aging, National Institute of Health, Baltimore, MD (United States)] [National Institute on Aging, National Institute of Health, Baltimore, MD (United States); Borojevic, Radovan [Biomedical Science Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ (Brazil)] [Biomedical Science Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ (Brazil)

2012-11-15T23:59:59.000Z

7

Bone marrow endothelium-targeted therapeutics for metastatic breast cancer  

Science Journals Connector (OSTI)

Abstract Effective treatment of cancer metastasis to the bone relies on bone marrow drug accumulation. The surface proteins in the bone marrow vascular endothelium provide docking sites for targeted drug delivery. We have developed a thioaptamer that specifically binds to E-selectin that is overexpressed in the vasculature of tumor and inflammatory tissues. In this study, we tested targeted delivery of therapeutic siRNA loaded in the E-selectin thioaptamer-conjugated multistage vector (ESTA-MSV) drug carrier to bone marrow for the treatment of breast cancer bone metastasis. We evaluated tumor type- and tumor growth stage-dependent targeting in mice bearing metastatic breast cancer in the bone, and carried out studies to identify factors that determine targeting efficiency. In a subsequent study, we delivered siRNA to knock down expression of the human STAT3 gene in murine xenograft models of human MDA-MB-231 breast tumor, and assessed therapeutic efficacy. Our studies revealed that the CD31+E-selectin+ population accounted for 20.8%, 26.4% and 29.9% of total endothelial cells respectively inside the femur of mice bearing early, middle and late stage metastatic MDA-MB-231 tumors. In comparison, the double positive cells remained at a basal level in mice with early stage MCF-7 tumors, and jumped to 23.9% and 28.2% when tumor growth progressed to middle and late stages. Accumulation of ESTA-MSV inside the bone marrow correlated with the E-selectin expression pattern. There was up to 5-fold enrichment of the targeted MSV in the bone marrow of mice bearing early or late stage MDA-MB-231 tumors and of mice with late stage, but not early stage, MCF-7 tumors. Targeted delivery of STAT3 siRNA in ESTA-MSV resulted in knockdown of STAT3 expression in 48.7% of cancer cells inside the bone marrow. Weekly systemic administration of ESTA-MSV/STAT3 siRNA significantly extended survival of mice with MDA-MB-231 bone metastasis. In conclusion, targeting the overexpressed E-selectin provides an effective approach for tissue-specific drug delivery to the bone marrow. Tumor growth in the bone can be effectively inhibited by blockage of the STAT3 signaling.

Junhua Mai; Yi Huang; Chaofeng Mu; Guodong Zhang; Rong Xu; Xiaojing Guo; Xiaojun Xia; David E. Volk; Ganesh L. Lokesh; Varatharasa Thiviyanathan; David G. Gorenstein; Xuewu Liu; Mauro Ferrari; Haifa Shen

2014-01-01T23:59:59.000Z

8

Effects of matrix metalloproteinase-1 on the myogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer MMP-1 is a member of the zinc-dependent endopeptidase family. Black-Right-Pointing-Pointer MMP-1 has no cytotoxic effects on BMSCs. Black-Right-Pointing-Pointer MMP-1 can promote the myogenic differentiation of BMSCs. Black-Right-Pointing-Pointer MyoD and desmin were chosen as myogenic markers in this study. -- Abstract: Matrix metalloproteinase-1 (MMP-1) is a member of the family of zinc-dependent endopeptidases that are capable of degrading extracellular matrix (ECM) and certain non-matrix proteins. It has been shown that MMP-1 can enhance muscle regeneration by improving the differentiation and migration of myoblasts. However, it is still not known whether MMP-1 can promote the myogenesis of bone marrow-derived mesenchymal stem cells (BMSCs). To address this question, we isolated BMSCs from C57BL/6J mice and investigated the effects of MMP-1 on their proliferation and myogenic differentiation. Our results showed that MMP-1 treatment, which had no cytotoxic effects on BMSCs, increased the mRNA and protein levels of MyoD and desmin in a dose-dependent manner, indicating that MMP-1 promoted myogenic differentiation of BMSCs in vitro. These results suggest that BMSCs may have a therapeutic potential for treating muscular disorders.

Zheng, Zhenyang [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China)] [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China); Leng, Yan [Department of Rehabilitation, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China)] [Department of Rehabilitation, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China); Zhou, Chen; Ma, Zhenyu; Zhong, Zhigang [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China)] [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China); Shi, Xing-Ming [Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, GA 30912 (United States)] [Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, GA 30912 (United States); Zhang, Weixi, E-mail: weixizhang@qq.com [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China)] [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China)

2012-11-16T23:59:59.000Z

9

Rescue from apoptosis in early (CD34-selected) versus late (non-CD34-selected) human hematopoietic cells by very late antigen 4- and vascular cell adhesion molecule (VCAM) 1-dependent adhesion to bone marrow stromal cells  

Science Journals Connector (OSTI)

...transplanted hematopoietic cells by bone marrow. Proc. NatI. Aced. Sci. USA, 85: 3180-3183, 1988. 18. Joling, P., Rademakers, L H. P. M., Verdaasdonk, M. A. M., Zimmermann, D., Spienngs, D. C. J., Werner, N., Werner, R. A...

MW Wang; U Consoli; CM Lane; A Durett; MJ Lauppe; R Champlin; M Andreeff; AB Deisseroth

1998-02-01T23:59:59.000Z

10

The effects of physiological age on bone marrow-derived mesenchymal stem cells  

E-Print Network [OSTI]

Jaenisch. Treatment of sickle cell anemia mouse model withcan be used to treat sickle cell anemia in a mouse model 5 ,

Buckspan, Caitlin

2010-01-01T23:59:59.000Z

11

Mutations in Bone Marrow-Derived Stromal Stem Cells Unmask Latent Malignancy  

E-Print Network [OSTI]

Neoplastic epithelia may remain dormant and clinically unapparent in human patients for decades. Multiple risk factors including mutations in tumor cells or the stromal cells may affect the switch from dormancy to malignancy. ...

Houghton, JeanMarie

12

Long-lived Inflammatory Signaling in Irradiated Bone Marrow Is Genome Dependent  

Science Journals Connector (OSTI)

...reduction in colony-forming efficiency (CFE)]. In addition, the bone marrow of irradiated...humidified atmosphere of 5% CO2 in air (17). CFE was determined by the number of colonies...irradiated producer bone marrow cells and the CFE of CFU-A determined. The protocol is...

Sally A. Lorimore; Debayan Mukherjee; Joanne I. Robinson; Jennifer A. Chrystal; Eric G. Wright

2011-10-15T23:59:59.000Z

13

Development of Ewing's Sarcoma from Primary Bone Marrow–Derived Mesenchymal Progenitor Cells  

Science Journals Connector (OSTI)

...corresponding web site. 9 9 http://intranet.isrec.ch/microarrays/nccr...Experimental Cancer Research. 10 10 http://intranet.isrec.ch/microarrays/arrays...cells with dense homogeneous nuclei, characteristic of EFT, occasionally organized into...

Nicolò Riggi; Luisa Cironi; Paolo Provero; Mario-Luca Suvà; Konstantinos Kaloulis; Carlos Garcia-Echeverria; Francesco Hoffmann; Andreas Trumpp; and Ivan Stamenkovic

2005-12-15T23:59:59.000Z

14

E-Print Network 3.0 - antibody-facilitated bone marrow Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of off... marrow, manifested as artifactual broadening of bone micro-structures in the image. The resulting images... (B0) at bone and bone marrow ... Source: Southern...

15

E-Print Network 3.0 - adult bone marrow-derived Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

32:69-77. 5. Garman R, Gaudette G, Donahue L, et al. 2007. Low... from bone marrow of young adult rats. Cell Tissue ... Source: You, Lidan - Department of Mechanical and...

16

Morphological, molecular and functional differences of adult bone marrow- and adipose-derived stem cells isolated from rats of different ages  

Science Journals Connector (OSTI)

Adult mesenchymal stem cells have self-renewal and multiple differentiation potentials, and play important roles in regenerative medicine. However, their use may be limited by senescence or age of the donor, leading to changes in stem cell functionality. We investigated morphological, molecular and functional differences between bone marrow-derived (MSC) and adipose-derived (ASC) stem cells isolated from neonatal, young and old rats compared to Schwann cells from the same animals. Immunocytochemistry, RT-PCR, proliferation assays, western blotting and transmission electron microscopy were used to investigate expression of senescence markers. Undifferentiated and differentiated ASC and MSC from animals of different ages expressed Notch-2 at similar levels; protein-38 and protein-53 were present in all groups of cells with a trend towards increased levels in cells from older animals compared to those from neonatal and young rats. Following co-culture with adult neuronal cells, dMSC and dASC from animals of all ages elicited robust neurite outgrowth. Mitotracker® staining was consistent with ultrastructural changes seen in the mitochondria of cells from old rats, indicative of senescence. In conclusion, this study showed that although the cells from aged animals expressed markers of senescence, aged MSC and ASC differentiated into SC-like cells still retain potential to support axon regeneration.

Cristina Mantovani; Stefania Raimondo; Maryam S. Haneef; Stefano Geuna; Giorgio Terenghi; Susan G. Shawcross; Mikael Wiberg

2012-01-01T23:59:59.000Z

17

No evidence for in vivo induction of genomic instability in bone marrow cells collected from mice exposed to low-dose 137Cs γ rays:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Rithidech et al, 2006 1 Rithidech et al, 2006 1 No evidence for in vivo induction of genomic instability in bone marrow cells collected from mice exposed to low-dose 137 Cs γ rays: Kanokporn Noy Rithidech 1 , Chatchanok Loetchutinat 1 , Louise Honikel 1 , and Elbert B. Whorton 2 1 Pathology Department, Stony Brook University, Stony Brook, NY 11794-8691 2 Molecular Epidemiology Research Program, University of Texas Medical Branch at Galveston, TX 77555-1153 Assessment of potential health risks associated with exposure to low-dose radiation (at doses below or equal to 0.1 Gy) is still a challenging public health issue. It is therefore important to improve our understanding of potential induction of genomic instability in vivo by this low-dose range because it has been widely suggested that elevation of genomic instability also elevates cancer

18

Analysis of Cell Cycle in Mouse Bone Marrow Cells Following Acute in vivo Exposure to 56Fe Ions  

Science Journals Connector (OSTI)

......Stony Brook University Stony Brook, NY 11794-8691 2 Molecular Epidemiology Program University of Texas Medical Branch at Galveston Galveston, TX 77555-1153 A pilot study was conducted to examine the magnitude of cell-cycle delay and apoptosis......

Kanokporn Noy Rithidech; Marc Golightly; Elbert Whorton

2008-07-01T23:59:59.000Z

19

Combined effects of mechanical strain and hydroxyapatite/collagen composite on osteogenic differentiation of rat bone marrow derived mesenchymal stem cells  

Science Journals Connector (OSTI)

Mesenchymal stem cells (MSCs) represent a promising source for bone repair and regeneration. Recent lines of evidence have shown that appropriate strain could regulate the osteogenic differentiation of MSCs. Our previous study demonstrated that hydroxyapatite/collagen ...

Yan Huang; Xufeng Niu; Wei Song; Changdong Guan; Qingling Feng; Yubo Fan

2013-01-01T23:59:59.000Z

20

E-Print Network 3.0 - adult bone-marrow-derived mesenchymal Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Washington at Seattle Collection: Biology and Medicine 34 Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Circulating Rat Platelets in Lethally X-radiated Mice Given Rat Bone Marrow  

Science Journals Connector (OSTI)

...MAKINODAN,ANDC. C. CONGDON (Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennestee) By the use of immunohematological...given injections of rat bone marrow. These same workers also identified a distinctive chromo some in dividing...

L. H. Smith; T. Makinodan; and C. C. Congdon

1957-06-01T23:59:59.000Z

22

Identification of Luminal Breast Cancers That Establish a Tumor-Supportive Macroenvironment Defined by Proangiogenic Platelets and Bone Marrow–Derived Cells  

Science Journals Connector (OSTI)

...green) and p-selectin (red; D). Cell nuclei stained with...harvested from indicated mice. Gate represents CD24+ populations...F and G, VEGFR2+ cells (red; F) and p-STAT3 (red) and...4906-13. 33. Abel EJ , Wood CG.Cytoreductive nephrectomy...

Hanna S. Kuznetsov; Timothy Marsh; Beth A. Markens; Zafira Castaño; April Greene-Colozzi; Samantha A. Hay; Victoria E. Brown; Andrea L. Richardson; Sabina Signoretti; Elisabeth M. Battinelli; and Sandra S. McAllister

2012-12-01T23:59:59.000Z

23

Cellular response of the primate (M. mulatta) spleen to bone marrow transplantation in gamma irradiated recipients  

E-Print Network [OSTI]

. They further stated that this disease was due to the combined effects of late radiation damage, immunologic reaction of the graft against the host and impaired immunologic defense against micro- organisms. Foreign bone marrow treatment was effective only... physicists who had been experimenting with a source that emitted neutron and gamma rays. Five of these physicists were exposed to lethal doses of ioniz- ing radiation. Hemograms taken on October 30, 1958, showed total aplasia. Supportive therapy had...

Fraunfelter, Frank Clare

1966-01-01T23:59:59.000Z

24

E-Print Network 3.0 - autologous marrow aspirate Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and to examine its effect Correspondence: Dr J Vredenburgh, Duke University... infusion was per- of tumor cells in bone marrow ... Source: Rabinowitz, Joshua D. -...

25

Quantifying murine bone marrow and blood radiation dose response following 18F-FDG PET with DNA damage biomarkers  

Science Journals Connector (OSTI)

Abstract The purpose of this study was to quantify the poorly understood radiation doses to murine bone marrow and blood from whole-body fluorine 18 (18F)-fluorodeoxyglucose (FDG) positron emission tomography (PET), by using specific biomarkers and comparing with whole body external low dose exposures. Groups of 3–5 mice were randomly assigned to 10 groups, each receiving either a different activity of 18F-FDG: 0–37 MBq or whole body irradiated with corresponding doses of 0–300 mGy X-rays. Blood samples were collected at 24 h and at 43 h for reticulocyte micronucleus assays and QPCR analysis of gene expression in peripheral blood leukocytes. Blood and bone marrow dose estimates were calculated from injected activities of 18F-FDG and were based on a recommended ICRP model. Doses to the bone marrow corresponding to 33.43 mGy and above for internal 18F-FDG exposure and to 25 mGy and above for external X-ray exposure, showed significant increases in radiation-induced MN-RET formation relative to controls (P dose–responses at 24 h for Bbc3 and Cdkn1 were similar for 18F-FDG and X-ray exposures, with significant modifications occurring for doses over 300 mGy for Bbc3 and at the lower dose of 150 mGy for Cdkn1a. Both leucocyte gene expression and quantification of MN-RET are highly sensitive biomarkers for reliable estimation of the low doses delivered in vivo to, respectively, blood and bone marrow, following 18F-FDG PET.

Grainne Manning; Kristina Taylor; Paul Finnon; Jennifer A. Lemon; Douglas R. Boreham; Christophe Badie

2014-01-01T23:59:59.000Z

26

Engineering tubular bone using mesenchymal stem cell sheets and coral particles  

SciTech Connect (OSTI)

Highlights: • We developed a novel engineering strategy to solve the limitations of bone grafts. • We fabricated tubular constructs using cell sheets and coral particles. • The composite constructs showed high radiological density and compressive strength. • These characteristics were similar to those of native bone. -- Abstract: The development of bone tissue engineering has provided new solutions for bone defects. However, the cell-scaffold-based approaches currently in use have several limitations, including low cell seeding rates and poor bone formation capacity. In the present study, we developed a novel strategy to engineer bone grafts using mesenchymal stem cell sheets and coral particles. Rabbit bone marrow mesenchymal stem cells were continuously cultured to form a cell sheet with osteogenic potential and coral particles were integrated into the sheet. The composite sheet was then wrapped around a cylindrical mandrel to fabricate a tubular construct. The resultant tubular construct was cultured in a spinner-flask bioreactor and subsequently implanted into a subcutaneous pocket in a nude mouse for assessment of its histological characteristics, radiological density and mechanical property. A similar construct assembled from a cell sheet alone acted as a control. In vitro observations demonstrated that the composite construct maintained its tubular shape, and exhibited higher radiological density, compressive strength and greater extracellular matrix deposition than did the control construct. In vivo experiments further revealed that new bone formed ectopically on the composite constructs, so that the 8-week explants of the composite sheets displayed radiological density similar to that of native bone. These results indicate that the strategy of using a combination of a cell sheet and coral particles has great potential for bone tissue engineering and repairing bone defects.

Geng, Wenxin [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)] [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China); Ma, Dongyang [Department of Oral and Maxillofacial Surgery, Lanzhou General Hospital, Lanzhou Command of PLA, BinHe 333 South Road, Lanzhou 730052 (China)] [Department of Oral and Maxillofacial Surgery, Lanzhou General Hospital, Lanzhou Command of PLA, BinHe 333 South Road, Lanzhou 730052 (China); Yan, Xingrong; Liu, Liangqi; Cui, Jihong; Xie, Xin; Li, Hongmin [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)] [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China); Chen, Fulin, E-mail: chenfl@nwu.edu.cn [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)] [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)

2013-04-19T23:59:59.000Z

27

Effect of Insulators on the Expression of betaAS3 in Lentiviral Gene Therapy for Sickle Cell Disease  

E-Print Network [OSTI]

al. (2001). Correction of sickle cell disease in transgenicto human bone marrow for sickle cell disease. Journal ofal. (2011). Correction of sickle cell disease in adult mice

Wherley, Jennifer Patricia

2013-01-01T23:59:59.000Z

28

Evaluation of morphological/immunohistochemical versus nuclear medicine imaging modalities in detecting metastatic bone and/or marrow deposits in neuroblastoma patients  

Science Journals Connector (OSTI)

Background & Purpose In planning diagnostic or follow-up investigational strategies, neuroblastoma (NB) metastatic deposits in bone and/or bone marrow (BM) should be detected as early as possible. Therefore, all investigational detection tools should be conducted simultaneously for precise staging. However, because of the financial conditions in our developing countries and in view of the cost/benefit relationship, the question is, can one detection tool only become satisfactory and replacing others? The purpose of our study is to compare simultaneous results of bone and metaiodobenzylguanidine (MIBG) scans versus BM biopsies with immunohistochemical (IHC) staining; in detecting bone and/or BM metastatic deposits in NB patients. Material and methods This study included 138 NB patients; 46 were de novo and 92 were under follow-up. They were subjected to bilateral BM biopsies, IHC staining (using NSE McAb) and Tc-99m methylene diphosphonate (Tc-99m MDP) bone scan (BS). Only 57/138 patients were, in addition, subjected to I-131 MIBG scan. Results Matched results between IHC-stained BM sections and bone scans (BSs) 107/138 (77.5%) were higher than the un-matched ones 31/138 (22.5%). There was a moderate agreement between the two methods in all studied cases (Kappa = 0.538) and it was higher among de novo (Kappa = 0.603) than follow-up group (Kappa = 0.511). Among the 31 un-matched results, the most frequent (17/31) were due to the presence of minute amount of infiltrating NB cells that could be detected by IHC-stained BM sections and not by BSs. The less frequent (12/31) were due to the presence of metastatic deposits outside pelvic bones that could be detected by \\{BSs\\} and not by IHC-stained BM sections mainly in the follow-up cases (11/12) rather than de novo cases (1/12). The matched results between IHC-stained BM sections and MIBG scans 54/57 (94.7%) were higher than the un-matched ones 3/57 (5.3%). The agreement between the two methods was higher among de novo (Kappa = 1.000) than follow-up group (Kappa = 0.847). The agreement between IHC-stained BM sections and MIBG scans was substantial (Kappa = 0.890) while that between IHC-stained BM sections and \\{BSs\\} was moderate (Kappa = 0.538). Conclusions We suggest a step-wise strategy to be applied, at least in developing countries, in approaching de novo and follow-up NB cases for detecting bone and/or BM metastatic deposits. This strategy might be beneficial if it is considered during application of NB guide-lines for diagnosis and follow-up.

Amr El-Sayed Zaher; Ahmed M. Zaher; Manar M. Moneer; Basma M. El Gamal

2011-01-01T23:59:59.000Z

29

Evaluation of dual energy quantitative CT for determining the spatial distributions of red marrow and bone for dosimetry in internal emitter radiation therapy  

SciTech Connect (OSTI)

Purpose: To evaluate a three-equation three-unknown dual-energy quantitative CT (DEQCT) technique for determining region specific variations in bone spongiosa composition for improved red marrow dose estimation in radionuclide therapy. Methods: The DEQCT method was applied to 80/140 kVp images of patient-simulating lumbar sectional body phantoms of three sizes (small, medium, and large). External calibration rods of bone, red marrow, and fat-simulating materials were placed beneath the body phantoms. Similar internal calibration inserts were placed at vertebral locations within the body phantoms. Six test inserts of known volume fractions of bone, fat, and red marrow were also scanned. External-to-internal calibration correction factors were derived. The effects of body phantom size, radiation dose, spongiosa region segmentation granularity [single (?17 × 17 mm) region of interest (ROI), 2 × 2, and 3 × 3 segmentation of that single ROI], and calibration method on the accuracy of the calculated volume fractions of red marrow (cellularity) and trabecular bone were evaluated. Results: For standard low dose DEQCT x-ray technique factors and the internal calibration method, the RMS errors of the estimated volume fractions of red marrow of the test inserts were 1.2–1.3 times greater in the medium body than in the small body phantom and 1.3–1.5 times greater in the large body than in the small body phantom. RMS errors of the calculated volume fractions of red marrow within 2 × 2 segmented subregions of the ROIs were 1.6–1.9 times greater than for no segmentation, and RMS errors for 3 × 3 segmented subregions were 2.3–2.7 times greater than those for no segmentation. Increasing the dose by a factor of 2 reduced the RMS errors of all constituent volume fractions by an average factor of 1.40 ± 0.29 for all segmentation schemes and body phantom sizes; increasing the dose by a factor of 4 reduced those RMS errors by an average factor of 1.71 ± 0.25. Results for external calibrations exhibited much larger RMS errors than size matched internal calibration. Use of an average body size external-to-internal calibration correction factor reduced the errors to closer to those for internal calibration. RMS errors of less than 30% or about 0.01 for the bone and 0.1 for the red marrow volume fractions would likely be satisfactory for human studies. Such accuracies were achieved for 3 × 3 segmentation of 5 mm slice images for: (a) internal calibration with 4 times dose for all size body phantoms, (b) internal calibration with 2 times dose for the small and medium size body phantoms, and (c) corrected external calibration with 4 times dose and all size body phantoms. Conclusions: Phantom studies are promising and demonstrate the potential to use dual energy quantitative CT to estimate the spatial distributions of red marrow and bone within the vertebral spongiosa.

Goodsitt, Mitchell M., E-mail: goodsitt@umich.edu; Shenoy, Apeksha; Howard, David; Christodoulou, Emmanuel; Dewaraja, Yuni K. [Department of Radiology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States)] [Department of Radiology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States); Shen, Jincheng [Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109 (United States)] [Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109 (United States); Schipper, Matthew J. [Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States)] [Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States); Wilderman, Scott [Department of Nuclear Engineering, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States)] [Department of Nuclear Engineering, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States); Chun, Se Young [Ulsan National Institute of Science and Technology (UNIST), School of Electrical and Computer Engineering, Ulsan 689-798 (Korea, Republic of)] [Ulsan National Institute of Science and Technology (UNIST), School of Electrical and Computer Engineering, Ulsan 689-798 (Korea, Republic of)

2014-05-15T23:59:59.000Z

30

Cell Fusion and Tissue Regeneration  

Science Journals Connector (OSTI)

Cell fusion is a natural process implicated in normal ... bone marrow stem cells fuse with several cell types, under normal condition or after an injury ... in regenerative medicine and genetic repair. Cell fusion

Manuel Álvarez-Dolado; Magdalena Martínez-Losa

2011-01-01T23:59:59.000Z

31

T cells stimulate catabolic gene expression by the stromal cells from giant cell tumor of bone  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Two T cell lines stimulate PTHrP, RANKL, MMP13 gene expression in GCT cell cultures. Black-Right-Pointing-Pointer CD40 expressed by stromal cells; CD40L detected in whole tumor but not cultures. Black-Right-Pointing-Pointer Effect of CD40L treatment on GCT cells increased PTHrP and MMP13 gene expression. Black-Right-Pointing-Pointer PTHrP treatment increased MMP13 expression, while inhibition decreased expression. Black-Right-Pointing-Pointer T cells may stimulate GCT stromal cells and promote the osteolysis of the tumor. -- Abstract: The factors that promote the localized bone resorption by giant cell tumor of bone (GCT) are not fully understood. We investigated whether T cells could contribute to bone resorption by stimulating expression of genes for parathyroid hormone-related protein (PTHrP), matrix metalloproteinase (MMP)-13, and the receptor activator of nuclear-factor {kappa}B ligand (RANKL). Two cell lines, Jurkat clone E6-1 and D1.1, were co-cultured with isolated GCT stromal cells. Real-time PCR analyses demonstrated a significant increase of all three genes following 48 h incubation, and PTHrP and MMP-13 gene expression was also increased at 24 h. Further, we examined the expression of CD40 ligand (CD40L), a protein expressed by activated T cells, and its receptor, CD40, in GCT. Immunohistochemistry results revealed expression of the CD40 receptor in both the stromal cells and giant cells of the tumor. RNA collected from whole GCT tissues showed expression of CD40LG, which was absent in cultured stromal cells, and suggests that CD40L is expressed within GCT. Stimulation of GCT stromal cells with CD40L significantly increased expression of the PTHrP and MMP-13 genes. Moreover, we show that inhibition of PTHrP with neutralizing antibodies significantly decreased MMP13 expression by the stromal cells compared to IgG-matched controls, whereas stimulation with PTHrP (1-34) increased MMP-13 gene expression. These results suggest that T cells may potentiate the catabolic effect of GCT.

Cowan, Robert W. [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada) [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada); Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada); Ghert, Michelle [Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada) [Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada); Department of Surgery, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada); Singh, Gurmit, E-mail: gurmit.singh@jcc.hhsc.ca [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada) [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada); Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada)

2012-03-23T23:59:59.000Z

32

Secreted Factors from Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury  

E-Print Network [OSTI]

Acute kidney injury is a devastating syndrome that afflicts over 2,000,000 people in the US per year, with an associated mortality of greater than 70% in severe cases. Unfortunately, standard-of-care treatments are not ...

Milwid, John Miles

2012-01-01T23:59:59.000Z

33

Transcriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor Cells  

E-Print Network [OSTI]

Hematopoietic stem cells (HSCs) maintain blood homeostasis and are the functional units of bone marrow transplantation. To improve the molecular understanding of HSCs and their proximal progenitors, we performed transcriptome ...

Gazit, Roi

34

Personalized estimation of dose to red bone marrow and the associated leukaemia risk attributable to pelvic kilo-voltage cone beam computed tomography scans in image-guided radiotherapy  

Science Journals Connector (OSTI)

The aim of this study is to investigate the imaging dose to red bone marrow (RBM) and the associated leukaemia risks attributable to pelvic kilo-voltage cone beam computed tomography (kVCBCT) scans in image-guided radiation therapy (IGRT). The RBM doses of 42 patients (age 2.7–86.4 years) were calculated using Monte Carlo simulations. The trabecular spongiosa was segmented to substitute RBM rather than the whole bone. Quantitative correlations between anthropometric variables such as age, physical bone density (PBD) and RBM dose were established. Personalized leukaemia risk was evaluated using an improved Boice model which included the age-associated RBM involvement. An incremental leukaemia risk of 29%–82% (mean = 45%) was found to be associated with 40 pelvic kVCBCT scans in the subject group used in a typical external beam radiation therapy course. Higher risks were observed in children. Due to the enhanced photoelectric effect in high atomic number materials, PBD was observed to strongly affect the RBM dose. Considerable overestimations (9%–42%, mean = 28%) were observed if the whole bone doses were used as surrogates of RBM doses. The personalized estimation of RBM dose and associated leukaemia risk caused by pelvic kVCBCT scans is clinically feasible with the proposed empirical models. Higher radiogenic cancer risks are associated with repeated kVCBCT scans in IGRT of cancer patients, especially children.

Yibao Zhang; Yulong Yan; Ravinder Nath; Shanglian Bao; Jun Deng

2012-01-01T23:59:59.000Z

35

Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment  

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...Engineering, Princeton University, , Princeton, NJ 08544, USA 3 Department of Physics, Princeton University, , Princeton, NJ 08544, USA 4 Department of...multiple myeloma (MM), a cancer of plasma cells in the bone marrow, becomes...

2014-01-01T23:59:59.000Z

36

Image-Guided Total-Marrow Irradiation Using Helical Tomotherapy in Patients With Multiple Myeloma and Acute Leukemia Undergoing Hematopoietic Cell Transplantation  

SciTech Connect (OSTI)

Purpose: Total-body irradiation (TBI) has an important role in patients undergoing hematopoietic cell transplantation (HCT), but is associated with significant toxicities. Targeted TBI using helical tomotherapy results in reduced doses to normal organs, which predicts for reduced toxicities compared with standard TBI. Methods and Materials: Thirteen patients with multiple myeloma were treated in an autologous tandem transplantation Phase I trial with high-dose melphalan, followed 6 weeks later by total-marrow irradiation (TMI) to skeletal bone. Dose levels were 10, 12, 14, and 16 Gy at 2 Gy daily/twice daily. In a separate allogeneic HCT trial, 8 patients (5 with acute myelogenous leukemia, 1 with acute lymphoblastic leukemia, 1 with non-Hodgkin's lymphoma, and 1 with multiple myeloma) were treated with TMI plus total lymphoid irradiation plus splenic radiotherapy to 12 Gy (1.5 Gy twice daily) combined with fludarabine/melphalan. Results: For the 13 patients in the tandem autologous HCT trial, median age was 54 years (range, 42-66 years). Median organ doses were 15-65% that of the gross target volume dose. Primarily Grades 1-2 acute toxicities were observed. Six patients reported no vomiting; 9 patients, no mucositis; 6 patients, no fatigue; and 8 patients, no diarrhea. For the 8 patients in the allogeneic HCT trial, median age was 52 years (range, 24-61 years). Grades 2-3 nausea, vomiting, mucositis, and diarrhea were observed. In both trials, no Grade 4 nonhematologic toxicity was observed, and all patients underwent successful engraftment. Conclusions: This study shows that TMI using helical tomotherapy is clinically feasible. The reduced acute toxicities observed compare favorably with those seen with standard TBI. Initial results are encouraging and warrant further evaluation as a method to dose escalate with acceptable toxicity or to offer TBI-containing regimens to patients unable to tolerate standard approaches.

Wong, Jeffrey Y.C. [Division of Radiation Oncology and Radiation Research, City of Hope Cancer Center, Duarte, CA (United States)], E-mail: jwong@coh.org; Rosenthal, Joseph [Division of Hematology and Hematopoietic Cell Transplantation, City of Hope Cancer Center, Duarte, CA (United States); Liu An; Schultheiss, Timothy [Division of Radiation Oncology and Radiation Research, City of Hope Cancer Center, Duarte, CA (United States); Forman, Stephen; Somlo, George [Division of Hematology and Hematopoietic Cell Transplantation, City of Hope Cancer Center, Duarte, CA (United States)

2009-01-01T23:59:59.000Z

37

CCR5 Receptor Antagonists Block Metastasis to Bone of v-Src Oncogene–Transformed Metastatic Prostate Cancer Cell Lines  

Science Journals Connector (OSTI)

...capability of prostate cancer cells to bone and brain, with immediate clinical implications...cell lines metastasized in FVB mice to brain and bone. Gene expression profiling of...cultures. The whole body, bone, and brain metastatic prostate cancer burden was reduced...

Daniela Sicoli; Xuanmao Jiao; Xiaoming Ju; Marco Velasco-Velazquez; Adam Ertel; Sankar Addya; Zhiping Li; Sebastiano Andò; Alessandro Fatatis; Bishnuhari Paudyal; Massimo Cristofanilli; Mathew L. Thakur; Michael P. Lisanti; Richard G. Pestell

2014-12-01T23:59:59.000Z

38

From a Dry Bone to a Genetic Portrait: A Case Study of Sickle Cell Anemia  

E-Print Network [OSTI]

From a Dry Bone to a Genetic Portrait: A Case Study of Sickle Cell Anemia MARINA FAERMAN,1* ALMUT identification; Y chromosome polymorphic markers; sickle cell anemia ABSTRACT The potential and reliability sample, which represented a documented case of sickle cell anemia. -globin gene sequences obtained from

39

Case 33-2014 — A 60-Year-Old Man with Bone Pain  

Science Journals Connector (OSTI)

...-microglobulin, results of liver-function tests and serum protein electrophoresis, and the 24-hour urinary histamine level. Testing for antibodies to human immunodeficiency virus types 1 and 2 was reportedly negative, as was FISH analysis for the BCR-ABL rearrangement and testing of peripheral-blood leukocytes... A 60-year-old man was seen in the outpatient cancer center because of bone pain that had lasted for 2 months and the presence of lytic bone lesions on imaging studies. Biopsy specimens of bone marrow and bone lesions showed increased mast cells. A diagnostic procedure was performed.

Choy E.Attar E.C.Oh K.S.Huang A.J.Kerr D.A.

2014-10-23T23:59:59.000Z

40

Mechanical interaction between cells and fluid for bone tissue engineering scaffold: Modulation of the interfacial shear stress  

E-Print Network [OSTI]

Mechanical interaction between cells and fluid for bone tissue engineering scaffold: Modulation Analytical solution Bone tissue engineering a b s t r a c t An analytical model of the fluid/cell mechanical n f o Article history: Accepted 1 November 2009 Keywords: Cell fluid interaction Shear stress

Guerraoui, Rachid

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41

E-Print Network 3.0 - anorganic bone clinical Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

predictor of bone mass... formation from bone marrow progenitors. Journal of ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

42

The Application of Flow Cytometry to Examine Damage Clearance in Stem Cells From Whole-Body Irradiated Mice  

SciTech Connect (OSTI)

The bone marrow contains many types of cells. Approximately 1-2% of these cells are critical for life, these are the so-called ‘bone marrow stem cells’ which divide indefinitely to produce platelets, red blood cells and white blood cells. Death of the bone marrow stem cells results in a diminished ability of the organism to make new blood cell components and can be fatal without medical intervention, such as a bone marrow transplant. Bone marrow stem cells are considered to be particularly sensitive to radiation injury. Therefore, it is important to understand how these cells response to total body radiation exposure and how these cells can be protected from radiation damage. The aim of this project was to determine if these critical cells in the bone marrow are susceptible to short-term and long-term injury after a whole-body exposure to a sub-lethal low dose of ionizing radiation. The overall aims were to determine if the extent of injury produced by the sub-lethal radiation exposure would be cleared from the stem cells and therefore present no long- term genetic risk to the organism, or if the radiation injury persisted and had an adverse long-term consequences for the cell genome. This research question is of interest in order to define the risks to exposed persons after occupational, accidental or terrorism-related sub-lethal low-dose radiation exposures. The novel aspect of this project was the methodology used to obtain the bone marrow stem cell-like cells and examining the outcomes of sub-lethal low-dose radiation in a mammalian animal model. Four radiation treatments were used: single treatments of 0.01Gy, 0.1 Gy, 1 Gy and ten treatments of 0.1 Gy given over 10 days. Bone marrow stem cell-like cells were then harvested 6 hours, 24 hours and 24 days later. The levels of radiation-induced cell death, damage to DNA and permanent changes to cellular DNA were measured in the isolated stem cell-like cells after each radiation treatment and time point and then the results were compared. As expected, the largest radiation dose produced the greatest level of damage but a linear relationship did not exist between cellular effects and radiation dose. The low dose exposures appeared to be more efficient at producing damage than the highest dose when normalized for the initial extent of damage. Additionally, immune stimulation given prior to radiation exposure appeared to protect the critical bone marrow stem cell population from radiation injury. The data suggest that the response of bone marrow stem-cell like cells to radiation injury is dependent on the extent of the initial levels of damage and the effects of total-body low-dose exposures can not be predicted by extrapolating from high dose exposures. This research has provided new information about the radiation sensitivity of bone marrow stem cell-like cells following total-body exposures, and suggests that these critical cells might be more sensitive to radiation than more mature cells in the bone marrow. Further work is need with intermediate radiation doses to confirm this conclusion.

Marples, Brian; Kovalchuk, Olga; McGonagle, Michele; Martinez, Alvaro; Wilson, George, D.

2010-02-26T23:59:59.000Z

43

Fisetin antagonizes cell fusion, cytoskeletal organization and bone resorption in RANKL-differentiated murine macrophages  

Science Journals Connector (OSTI)

Abstract Osteoclastogenesis is comprised of several stage s including progenitor survival, differentiation to mononuclear preosteoclasts, cell fusion to multinuclear mature osteoclasts, and activation to osteoclasts with bone resorbing activity. Botanical antioxidants are now being increasingly investigated for their health-promoting effects on bone. This study investigated that fisetin, a flavonol found naturally in many fruits and vegetables, suppressed osteoclastogenesis by disturbing receptor activator of nuclear factor (NF)-?B ligand (RANKL)-mediated signaling pathway and demoting osteoclastogenic protein induction. Nontoxic fisetin at ?10?M inhibited the induction of RANK, tumor necrosis factor receptor associated factor 6 (TRAF6) and the activation of NF-?B in RANKL-stimulated RAW 264.7 macrophages. In RANKL-differentiated osteoclasts cell fusion protein of E-cadherin was induced, which was dampened by fisetin. The formation of tartrate-resistance acid phosphatase-positive multinucleated osteoclasts was suppressed by adding fisetin to RANKL-exposed macrophages. It was also found that fisetin reduced actin ring formation and gelsolin induction of osteclasts enhanced by RANKL through disturbing c-Src-proline-rich tyrosine kinase 2 signaling. Fisetin deterred preosteoclasts from the cell-cell fusion and the organization of the cytoskeleton to seal the resorbing area and to secret protons for bone resorption. Consistently, the 5 day-treatment of fisetin diminished RANKL-induced cellular expression of carbonic anhydrase II and integrin ?3 concurrently with a reduction of osteoclast bone-resorbing activity. Therefore, fisetin was a natural therapeutic agent retarding osteoclast fusion and cytoskeletal organization such as actin rings and ruffled boarder, which is a property of mature osteoclasts and is required for osteoclasts to resorb bone.

Yun-Ho Kim; Jung-Lye Kim; Eun-Jung Lee; Sin-Hye Park; Seon-Young Han; Soon Ah Kang; Young-Hee Kang

2014-01-01T23:59:59.000Z

44

Organosilicate nanoparticles as gene delivery vehicles for bone cells  

E-Print Network [OSTI]

(cont.) proliferation. The metabolic response of these cells after particle ingestion was also characterized in order to ensure that the osteoblasts retained their phenotype. The expression of various proteins involved in ...

Moudgil, Suniti, 1976-

2004-01-01T23:59:59.000Z

45

Lung Metastasis Fails in MMTV-PyMT Oncomice Lacking S100A4 Due to a T-Cell Deficiency in Primary Tumors  

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...behavior and promoting tumor invasion and metastasis. Contra wise, they can show pronounced antitumorigenic activity (2, 3...that promote metastasis. Cancer Cell 2008;13:23-35. 45 Alison MR , Lim S Houghton JM. Bone marrow-derived cells and epithelial...

Birgitte Grum-Schwensen; Jörg Klingelhöfer; Mariam Grigorian; Kasper Almholt; Boye Schnack Nielsen; Eugene Lukanidin; and Noona Ambartsumian

2010-02-01T23:59:59.000Z

46

Effects of cyclic stretch on proliferation of mesenchymal stem cells and their differentiation to smooth muscle cells  

SciTech Connect (OSTI)

Bone marrow mesenchymal stem cells (MSCs) are capable of differentiating into a variety of cell types such as vascular smooth muscle cells (SMCs). In this study, we investigated influence of cyclic stretch on proliferation of hMSCs for different loading conditions, alignment of actin filaments, and consequent differentiation to SMCs. Isolated cells from bone marrow were exposed to cyclic stretch utilizing a customized device. Cell proliferation was examined by MTT assay, alignment of actin fibers by a designed image processing code, and cell differentiation by fluorescence staining. Results indicated promoted proliferation of hMSCs by cyclic strain, enhanced by elevated strain amplitude and number of cycles. Such loading regulated smooth muscle {alpha}-actin, and reoriented actin fibers. Cyclic stretch led to differentiation of hMSCs to SMCs without addition of growth factor. It was concluded that applying appropriate loading treatment on hMSCs could enhance proliferation capability, and produce functional SMCs for engineered tissues.

Ghazanfari, Samane [Cardiovascular Engineering Lab., Faculty of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran (Iran, Islamic Republic of) [Cardiovascular Engineering Lab., Faculty of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran (Iran, Islamic Republic of); National Cell Bank of Iran, Pasteur Institute of Iran, Tehran (Iran, Islamic Republic of); Tafazzoli-Shadpour, Mohammad, E-mail: tafazoli@aut.ac.ir [Cardiovascular Engineering Lab., Faculty of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran (Iran, Islamic Republic of)] [Cardiovascular Engineering Lab., Faculty of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran (Iran, Islamic Republic of); Shokrgozar, Mohammad Ali [National Cell Bank of Iran, Pasteur Institute of Iran, Tehran (Iran, Islamic Republic of)] [National Cell Bank of Iran, Pasteur Institute of Iran, Tehran (Iran, Islamic Republic of)

2009-10-23T23:59:59.000Z

47

Acceleration of bone development and regeneration through the Wnt/?-catenin signaling pathway in mice heterozygously deficient for GSK-3?  

SciTech Connect (OSTI)

Highlights: •The Wnt/?-catenin signaling pathway was activated in GSK-3?{sup +/?} mice. •The cortical and trabecular bone volumes were increased in GSK-3?{sup +/?} mice. •Regeneration of a partial bone defect was accelerated in GSK-3?{sup +/?} mice. -- Abstract: Glycogen synthase kinase (GSK)-3? plays an important role in osteoblastogenesis by regulating the Wnt/?-catenin signaling pathway. Therefore, we investigated whether GSK-3? deficiency affects bone development and regeneration using mice heterozygously deficient for GSK-3? (GSK-3?{sup +/?}). The amounts of ?-catenin, c-Myc, cyclin D1, and runt-related transcription factor-2 (Runx2) in the bone marrow cells of GSK-3?{sup +/?} mice were significantly increased compared with those of wild-type mice, indicating that Wnt/?-catenin signals were enhanced in GSK-3?{sup +/?} mice. Microcomputed tomography of the distal femoral metaphyses demonstrated that the volumes of both the cortical and trabecular bones were increased in GSK-3?{sup +/?} mice compared with those in wild-type mice. Subsequently, to investigate the effect of GSK-3? deficiency on bone regeneration, we established a partial bone defect in the femur and observed new bone at 14 days after surgery. The volume and mineral density of the new bone were significantly higher in GSK-3?{sup +/?} mice than those in wild-type mice. These results suggest that bone formation and regeneration in vivo are accelerated by inhibition of GSK-3?, probably through activation of the Wnt/?-catenin signaling pathway.

Arioka, Masaki [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan) [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan); Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka (Japan); Takahashi-Yanaga, Fumi, E-mail: yanaga@clipharm.med.kyushu-u.ac.jp [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan) [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan); Global Medical Science Education Unit, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan); Sasaki, Masanori [Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka (Japan)] [Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka (Japan); Yoshihara, Tatsuya; Morimoto, Sachio [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan); Takashima, Akihiko [Department of Aging Neurobiology, National Center for Geriatrics and Gerontology, Oobu (Japan)] [Department of Aging Neurobiology, National Center for Geriatrics and Gerontology, Oobu (Japan); Mori, Yoshihide [Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka (Japan)] [Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka (Japan); Sasaguri, Toshiyuki [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan)

2013-11-01T23:59:59.000Z

48

DU145 human prostate cancer cells express functional Receptor Activator of NF-B: New insights in the prostate cancer bone metastasis process.  

E-Print Network [OSTI]

1 DU145 human prostate cancer cells express functional Receptor Activator of NF-B: New insights in the prostate cancer bone metastasis process. Mori K.1, 2, * , Le Goff B. 1, 2 , Charrier C. 1, 2 , Battaglia S;40(4):981-90" DOI : 10.1016/j.bone.2006.11.006 #12;2 Abstract Prostate cancer metastases to bone are observed

Boyer, Edmond

49

E-Print Network 3.0 - alveolar bone cells Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

; Biology and Medicine 4 The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial Summary: tooth sockets by preventing...

50

The effects of vibration loading on adipose stem cell number, viability and differentiation towards bone-forming cells  

Science Journals Connector (OSTI)

...used in clinical bone tissue engineering [33,34]. Vibration stimuli...of ASC-based bone tissue engineering constructs. As recent findings...and built at the Biomedical Engineering Department, Tampere University...amplified by a T.AMP E800 audio amplifier (Musikhaus Thomann...

2011-01-01T23:59:59.000Z

51

Differential Effect of Hyperthermia on Murine Bone Marrow Normal Colony-forming Units and AKR and L1210 Leukemia Stem Cells  

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...M., and Chaplain, R. Selektionssteigerung der Strahlenther apeutischen Wirkung durch Manipulierte Tumor oebers uerungund Wurme. Naturwissenschaften, 55: 448,1968. 34. Waters, R. L., and Roti Roti, J. L. The effect of hyperthermia on replicating...

M. Flentje; D. Flentje; S. A. Sapareto

1984-05-01T23:59:59.000Z

52

Health Care Utilization by Adult Long-term Survivors of Hematopoietic Cell Transplant: Report from the Bone Marrow Transplant Survivor Study  

Science Journals Connector (OSTI)

...Cancer Research Article Research Articles Health Care Utilization by Adult Long-term...risk of long-term complications and health care needs among survivors. The aim of...was to evaluate the current status of health care utilization by long-term HCT survivors...

Sadhna M. Shankar; Andrea Carter; Can-Lan Sun; Liton Francisco; K. Scott Baker; James G. Gurney; Daniel G. Weisdorf; Stephen J. Forman; Leslie L. Robison; Marcia Grant; Smita Bhatia

2007-04-01T23:59:59.000Z

53

Elimination of B-Lymphoma Cells from Human Bone Marrow: Model Experiments Using Monodisperse Magnetic Particles Coated with Primary Monoclonal Antibodies  

Science Journals Connector (OSTI)

...particles have a diameter of 4.5 ion and a surface area of 3 to 5 m2 per g, and they contain 20% iron in the form of 7-Fe2O3. The preparation contains 1.4 x 10' particles per g. The surface of the particle is partly hydrophobic, allowing antibodies...

Gunnar Kvalheim; Øystein Fodstad; Alexander Pihl; Kjell Nustad; Anne Pharo; John Ugelstad; Steinar Funderud

1987-02-01T23:59:59.000Z

54

In vitro and in vivo growth factor delivery to chondrocytes and bone-marrow-derived stromal cells in cartilage and in self-assembling peptide scaffolds  

E-Print Network [OSTI]

The inability of articular cartilage to repair itself after acute injury has been implicated in the development of osteoarthritis. The objective of this work was to develop methods for delivering growth factors to cartilage ...

Miller, Rachel E. (Rachel Elizabeth)

2010-01-01T23:59:59.000Z

55

Radiobiological modelling with MarCell software  

SciTech Connect (OSTI)

Jones introduced a bone marrow radiation cell kinetics model with great potential for application in the fields of health physics, radiation research, and medicine. However, until recently, only the model developers have been able to apply it because of the complex array of biological and physical assignments needed for evaluation of a particular radiation exposure protocol. The purpose of this article is to illustrate the use of MarCell (MARrow CELL Kinetics) software for MS-DOS, a user-friendly computer implementation of that mathematical model that allows almost anyone with an elementary knowledge of radiation physics and/or medical procedures to apply the model. A hands-on demonstration of the software will be given by guiding the user through evaluation of a medical total body irradiation protocol and a nuclear fallout scenario. A brief overview of the software is given in the Appendix.

Hasan, J.S.; Jones, T.D.

1996-10-01T23:59:59.000Z

56

E-Print Network 3.0 - alveolar bone-derived cells Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Respiratory Physiology 2 Pulmonary Mechanics Summary: , 3rd Ed. Fig. 10.2 12;Surfactant Secretion by Type II Alveolar Epithelial Cells from multilamellar... basal laminabasement...

57

Clone Wars — The Emergence of Neoplastic Blood-Cell Clones with Aging  

Science Journals Connector (OSTI)

...all-cause mortality, coronary heart disease, and ischemic stroke (hazard ratios, 1.4 to 2.6), suggesting that it might be a surrogate for failing health with aging as well as a specific risk factor for hematologic cancers. There are several reasons why normal aging might confer a predisposition to clonal... Blood cells originate from hematopoietic stem cells (HSCs). HSCs are infrequent (<2 per 108 bone marrow cells, or about 11,000 to 22,000 per person) and rarely divide.1,2 Because mutations occur with DNA replication during cell division, HSC quiescence ...

2014-11-26T23:59:59.000Z

58

Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering  

Science Journals Connector (OSTI)

Low oxygen pressure (hypoxia) plays an important role in stimulating angiogenesis; there are, however, few studies to prepare hypoxia-mimicking tissue engineering scaffolds. Mesoporous bioactive glass (MBG) has been developed as scaffolds with excellent osteogenic properties for bone regeneration. Ionic cobalt (Co) is established as a chemical inducer of hypoxia-inducible factor (HIF)-1?, which induces hypoxia-like response. The aim of this study was to develop hypoxia-mimicking MBG scaffolds by incorporating ionic Co2+ into MBG scaffolds and investigate if the addition of Co2+ ions would induce a cellular hypoxic response in such a tissue engineering scaffold system. The composition, microstructure and mesopore properties (specific surface area, nano-pore volume and nano-pore distribution) of Co-containing MBG (Co-MBG) scaffolds were characterized and the cellular effects of Co on the proliferation, differentiation, vascular endothelial growth factor (VEGF) secretion, HIF-1? expression and bone-related gene expression of human bone marrow stromal cells (BMSCs) in MBG scaffolds were systematically investigated. The results showed that low amounts of Co (ions into MBG scaffolds is a viable option for preparing hypoxia-mimicking tissue engineering scaffolds and significantly enhanced hypoxia function. The hypoxia-mimicking MBG scaffolds have great potential for bone tissue engineering applications by combining enhanced angiogenesis with already existing osteogenic properties.

Chengtie Wu; Yinghong Zhou; Wei Fan; Pingping Han; Jiang Chang; Jones Yuen; Meili Zhang; Yin Xiao

2012-01-01T23:59:59.000Z

59

In vitro and in vivo evaluation of akermanite bioceramics for bone regeneration  

Science Journals Connector (OSTI)

This study investigated the effects of a calcium magnesium silicate bioceramic (akermanite) for bone regeneration in vitro and in vivo, with ?-tricalcium phosphate (?-TCP) as a control. In vitro, the human bone marrow-derived mesenchymal stromal cells (hBMSCs) were cultured in an osteogenic medium supplemented with a certain concentration of two bioceramics' extracts for 20 days. An MTT assay showed that akermanite extract promoted proliferation of hBMSC significantly more than did ?-TCP extract. The results of alkaline phosphatase (ALP) activity test and the expression of osteogenic marker genes such as ALP, osteopontin (OPN), osteocalcin (OCN) and bone sialoprotein (BSP) demonstrated that the osteogenic differentiation of hBMSC was enhanced more by akermanite extract than by ?-TCP extract. In vivo, a histomorphology analysis and histomorphometry of the two porous bioceramics implants in rabbit femur defect models indicated that both in early- and late-stage implantations, akermanite promoted more osteogenesis and biodegradation than did ?-TCP; and in late-stage implantations, the rate of new bone formation was faster in akermanite than in ?-TCP. These results suggest that akermanite might be a potential and attractive bioceramic for tissue engineering.

Yan Huang; Xiaogang Jin; Xiaoling Zhang; Hongli Sun; Jinwen Tu; Tingting Tang; Jiang Chang; Kerong Dai

2009-01-01T23:59:59.000Z

60

The X-ray attenuation characteristics and density of human calcaneal marrow do not change significantly during adulthood  

E-Print Network [OSTI]

The X-ray attenuation characteristics and density of human calcaneal marrow do not change be a significant source of error in measurements of bone density when using X-ray and ultrasound imaging modalities calcanei (28 males, 6 females, ages 17­65 years). The density and energy-dependent linear X-ray attenuation

Stanford University

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61

Identification of Ror? targets in cultured osteoblasts and in human bone  

SciTech Connect (OSTI)

Highlights: •We examine the gene expression patterns controlled by Ror? in osteoblasts. •Genes involved in extracellular matrix regulation and proliferation are affected. •Ror? mRNA levels increase in aged, human bone biopsies. •Ror? may affect osteoblast activity by modulation of these pathways. -- Abstract: Control of osteoblastic bone formation involves the cumulative action of numerous transcription factors, including both activating and repressive functions that are important during specific stages of differentiation. The nuclear receptor retinoic acid receptor-related orphan receptor ? (Ror?) has been recently shown to suppress the osteogenic phenotype in cultured osteoblasts, and is highly upregulated in bone marrow-derived osteogenic precursors isolated from aged osteoporotic mice, suggesting Ror? is an important regulator of osteoblast function. However the specific gene expression patterns elicited by Ror? are unknown. Using microarray analysis, we identified 281 genes regulated by Ror? in an MC3T3-E1 mouse osteoblast cell model (MC3T3-Ror?-GFP). Pathway analysis revealed alterations in genes involved in MAPK signaling, genes involved in extracellular matrix (ECM) regulation, and cytokine-receptor interactions. Whereas the identified Ror?-regulated ECM genes normally decline during osteoblastic differentiation, they were highly upregulated in this non-mineralizing MC3T3-Ror?-GFP model system, suggesting that Ror? may exert its anti-osteogenic effects through ECM disruption. Consistent with these in vitro findings, the expression of both ROR? and a subset of ROR?-regulated genes were increased in bone biopsies from postmenopausal women (73 ± 7 years old) compared to premenopausal women (30 ± 5 years old), suggesting a role for ROR? in human age-related bone loss. Collectively, these data demonstrate that Ror? regulates known osteogenic pathways, and may represent a novel therapeutic target for age-associated bone loss.

Roforth, Matthew M., E-mail: roforth.matthew@mayo.edu; Khosla, Sundeep, E-mail: khosla.sundeep@mayo.edu; Monroe, David G., E-mail: monroe.david@mayo.edu

2013-11-01T23:59:59.000Z

62

Reactivity of Anti-CD15 Monoclonal Antibody PM-81 with Breast Cancer and Elimination of Breast Cancer Cells from Human Bone Marrow by PM-81 and Immunomagnetic Beads  

Science Journals Connector (OSTI)

...immunomagnetic beads, Dynabeads R (Dynal, Oslo, Norway), are 4.5-mm polystyrene beads with 20% iron in the form 7-Fe2O3 and have a magnetic susceptibility of approximately 10~2cgs units (19). Dynabeads covalently coated with sheep-anti-mouse...

James J. Vredenburgh; Wendy Simpson; Vincent A. Memoli; Edward D. Ball

1991-05-01T23:59:59.000Z

63

Transgenic expression of BRCA1 disturbs hematopoietic stem and progenitor cells quiescence and function  

SciTech Connect (OSTI)

The balance between quiescence and proliferation of HSCs is an important regulator of hematopoiesis. Loss of quiescence frequently results in HSCs exhaustion, which underscores the importance of tight regulation of proliferation in these cells. Studies have indicated that cyclin-dependent kinases are involved in the regulation of quiescence in HSCs. BRCA1 plays an important role in the repair of DNA double-stranded breaks, cell cycle, apoptosis and transcription. BRCA1 is expressed in the bone marrow. However, the function of BRCA1 in HSCs is unknown. In our study, we generated BRCA1 transgenic mice to investigate the effects of BRCA1 on the mechanisms of quiescence and differentiation in HSCs. The results demonstrate that over-expression of BRCA1 in the bone marrow impairs the development of B lymphocytes. Furthermore, BRCA1 induced an increase in the number of LSKs, LT-HSCs, ST-HSCs and MPPs. A competitive transplantation assay found that BRCA1 transgenic mice failed to reconstitute hematopoiesis. Moreover, BRCA1 regulates the expression of p21{sup waf1}/cip1 and p57{sup kip2}, which results in a loss of quiescence in LSKs. Together, over-expression of BRCA1 in bone marrow disrupted the quiescent of LSKs, induced excessive accumulation of LSKs, and disrupted differentiation of the HSCs, which acts through the down-regulated of p21{sup waf1}/cip1 and p57{sup kip2}. - Highlights: • Over-expression of BRCA1 results in impaired B lymphocyte development. • BRCA1 transgenic mice disrupted the quiescent of LSKs, induced excessive accumulation of LSKs. • BRCA1 impairs the function of HSCs through the down-regulated of p21{sup waf1/cip1} and p57{sup kip2}.

Bai, Lin; Shi, Guiying; Zhang, Xu; Dong, Wei; Zhang, Lianfeng, E-mail: zhanglf@cnilas.org

2013-10-15T23:59:59.000Z

64

Effects of Monoclonal Antibody and Complement Treatment of Human Marrow on Hematopoiesis in Continuous Bone Marrow Culture  

Science Journals Connector (OSTI)

...conjugate of three monoclonalantibodies. Science(Wash. DC),222: 512-515, 1983. 51. Vand de Wijngaert, F. P., and Rademakers, L. H. P. M., Schuurman, H-J., deWeger, R. A., and Kater, L. Identification and in situ localization of the...

Joel S. Greenberger; Lisa Rothstein; Paolo DeFabritiis; Marco Bregni; Robert Bast, Jr.; Jerome Ritz; Lee M. Nadler; Jeffrey M. Lipton; Mary Ann Sakakeeny

1985-02-01T23:59:59.000Z

65

Protocadherin-7 induces bone metastasis of breast cancer  

SciTech Connect (OSTI)

Highlights: •PCDH7 is overexpression in high bone metastatic MDA-MB-231 cells. •PCDH7 is up-regulation in bone metastatic breast cancer tissues. •Suppression of PCDH7 inhibits cell proliferation, migration, and invasion in vitro. •PCDH7 induces breast cancer bone metastasis in vivo. -- Abstract: Breast cancer had a propensity to metastasize to bone, resulting in serious skeletal complications associated with poor outcome. Previous study showed that Protocadherin-7 (PCDH7) play an important role in brain metastatic breast cancer, however, the role of PCDH7 in bone metastatic breast cancer has never been explored. In the present study, we found that PCDH7 expression was up-regulation in bone metastatic breast cancer tissues by real-time PCR and immunohistochemistry assays. Furthermore, suppression of PCDH7 inhibits breast cancer cell proliferation, migration, and invasion in vitro by MTT, scratch, and transwell assays. Most importantly, overexpression of PCDH7 promotes breast cancer cell proliferation and invasion in vitro, and formation of bone metastasis in vivo. These data provide an important insight into the role of PCDH7 in bone metastasis of breast cancer.

Li, Ai-Min [Department of Orthopedics, The 5th Central Hospital of Tianjin, Tianjin (China)] [Department of Orthopedics, The 5th Central Hospital of Tianjin, Tianjin (China); Tian, Ai-Xian [Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)] [Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Zhang, Rui-Xue [Department of Clinical Laboratory Diagnosis, Tianjin Medical University, Tianjin (China)] [Department of Clinical Laboratory Diagnosis, Tianjin Medical University, Tianjin (China); Ge, Jie [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Sun, Xuan [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)] [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Cao, Xu-Chen, E-mail: caoxuch@126.com [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)

2013-07-05T23:59:59.000Z

66

Biodegradable synthetic bone composites  

DOE Patents [OSTI]

The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

Liu, Gao; Zhao, Dacheng; Saiz, Eduardo; Tomsia, Antoni P.

2013-01-01T23:59:59.000Z

67

Repair of DNA Alkylation Induced in L1210 Leukemia and Murine Bone Marrow by Three Chloroethylnitrosoureas  

Science Journals Connector (OSTI)

...cross-links proceeds much more slowly than does repair of monoadducts; we observed that...cross-links. Further, removal of label does not ensure that the full process of excision...Sartorelli and D. G. Johns (eds.). Handbook of Experimental Pharma cology, Vol. 38...

James D. Ahlgren; Dianna C. Green; Kenneth D. Tew; and Philip S. Schein

1982-07-01T23:59:59.000Z

68

Accounting for beta-particle energy loss to cortical bone via paired-image radiation transport (PIRT)  

SciTech Connect (OSTI)

Current methods of skeletal dose assessment in both medical physics (radionuclide therapy) and health physics (dose reconstruction and risk assessment) rely heavily on a single set of bone and marrow cavity chord-length distributions in which particle energy deposition is tracked within an infinite extent of trabecular spongiosa, with no allowance for particle escape to cortical bone. In the present study, we introduce a paired-image radiation transport (PIRT) model which provides a more realistic three-dimensional (3D) geometry for particle transport in the skeletal site at both microscopic and macroscopic levels of its histology. Ex vivo CT scans were acquired of the pelvis, cranial cap, and individual ribs excised from a 66-year male cadaver (BMI of 22.7 kg m{sup -2}). For the three skeletal sites, regions of trabecular spongiosa and cortical bone were identified and segmented. Physical sections of interior spongiosa were taken and subjected to microCT imaging. Voxels within the resulting microCT images were then segmented and labeled as regions of bone trabeculae, endosteum, active marrow, and inactive marrow through application of image processing algorithms. The PIRT methodology was then implemented within the EGSNRC radiation transport code whereby electrons of various initial energies are simultaneously tracked within both the ex vivo CT macroimage and the CT microimage of the skeletal site. At initial electron energies greater than 50-200 keV, a divergence in absorbed fractions to active marrow are noted between PIRT model simulations and those estimated under existing techniques of infinite spongiosa transport. Calculations of radionuclide S values under both methodologies imply that current chord-based models may overestimate the absorbed dose to active bone marrow in these skeletal sites by 0% to 27% for low-energy beta emitters ({sup 33}P, {sup 169}Er, and {sup 177}Lu), by {approx}4% to 49% for intermediate-energy beta emitters ({sup 153}Sm, {sup 186}Re, and {sup 89}Sr), and by {approx}14% to 76% for high-energy beta emitters ({sup 32}P, {sup 188}Re, and {sup 90}Y). The PIRT methodology allows for detailed modeling of the 3D macrostructure of individual marrow-containing bones within the skeleton thus permitting improved estimates of absorbed fractions and radionuclide S values for intermediate-to-high energy beta emitters.

Shah, Amish P.; Rajon, Didier A.; Patton, Phillip W.; Jokisch, Derek W.; Bolch, Wesley E. [Department of Biomedical Engineering and Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida 32611 (United States); Deparment of Neurosurgery, University of Florida, Gainesville, Florida 32611 (United States); Department of Health Physics, University of Nevada-Las Vegas, Las Vegas, Nevada (United States); Department of Physics and Astronomy, Francis Marion University, Florence, South Carolina 29501-0547 (United States); Department of Biomedical Engineering and Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida 32611 (United States)

2005-05-01T23:59:59.000Z

69

Differentiation of mesenchymal stem cells to support peripheral nerve regeneration in a rat model  

Science Journals Connector (OSTI)

Mesenchymal stem cells (MSCs) support axon regeneration across artificial nerve bridges but their differentiative capacity and ability to promote nerve regeneration remains unclear. In this study, \\{MSCs\\} isolated from bone marrow of Sprague–Dawley rats were characterized by plastic adherence and pluripotency towards mesodermal lineages. Isolated undifferentiated \\{MSCs\\} (uMSCs) were stimulated towards a Schwann cell (SC) phenotype using specific growth factors, and cell marker analysis was performed to verify SC phenotype in vitro. Differentiation resulted in temporally dependent positive immunocytochemical staining for the SC markers, glial fibrillary acidic protein (GFAP), S100, and nerve growth factor receptor (NGFR), with maximal marker expression achieved after 6 days of treatment with differentiation media. Quantitative analysis demonstrated that ~ 50% of differentiated \\{MSCs\\} (dMSCs) have a SC phenotype. Using an indirect co-culture system, we compared the ability of dorsal root ganglion (DRG) cells to extend neurites in indirect contact with uMSCs and dMSCs as compared to SCs. The mean values of the longest length of the DRG neurites were the same for the dMSCs and \\{SCs\\} and significantly higher than the uMSC and DRG mono-culture systems (p dMSC seeded collagen nerve conduits resulted in a greater number of sciatic motoneurons regenerating axons through the conduit into the distal nerve stump. We conclude that bone marrow-derived \\{MSCs\\} differentiate into a SC-phenotype that expresses SC markers transiently and sufficiently to support limited neurite outgrowth in vitro and axonal regeneration equivalent to that of \\{SCs\\} in vitro and in vivo. The nerve autograft remains the most effective conduit for supporting regeneration across nerve gaps.

A. Ladak; J. Olson; E.E. Tredget; T. Gordon

2011-01-01T23:59:59.000Z

70

Polymeric nanoparticle-mediated silencing of CD44 receptor in CD34+ acute myeloid leukemia cells  

Science Journals Connector (OSTI)

Abstract The adhesion receptor CD44 plays an important role in the survival and retention of leukemic stem/progenitor cells (LSPC) within the bone marrow (BM) niche, as well as in the high relapse rates of acute myeloid leukemia (AML). Down-regulating CD44 could be clinically relevant not only for suppression of the deregulated function of LSPC but also in LSPC response to chemotherapeutic agents. Small interfering RNA (siRNA) delivery is a promising approach for AML treatment, and we recently reported effective siRNA delivery into difficult-to-transfect AML cell lines using lipid-substituted polyethylenimine/siRNA complexes (polymeric nanoparticles). In this study, we investigated polymeric nanoparticle-mediated silencing of CD44 in CD34+ LSPC cell models (leukemic KG-1 and KG-1a cell lines) as well as primary AML cells. Polymeric nanoparticle-mediated silencing decreased surface CD44 levels in KG-1, KG-1a and primary AML cells by up to 27%, 30% and 20% at day 3, respectively. Moreover, CD44 silencing resulted in induction of apoptosis in KG-1 cells, reduced adhesion of KG-1 and KG-1a cells to hyaluronic acid-coated cell culture plates and BM-MSC, and decreased adhesion of primary AML cells to BM-MSC. Our results suggest that polymeric nanoparticle-mediated silencing of CD44 might be a useful technique for inhibiting LSPC interactions with their microenvironment, thereby prohibiting leukemia progression or sensitizing LSPC to chemotherapy.

Hilal Gul-Uluda?; Juliana Valencia-Serna; Cezary Kucharski; Leah A. Marquez-Curtis; Xiaoyan Jiang; Loree Larratt; Anna Janowska-Wieczorek; Hasan Uluda?

2014-01-01T23:59:59.000Z

71

The ?-Receptor for Platelet-Derived Growth Factor Confers Bone-Metastatic Potential to Prostate Cancer Cells by Ligand- and Dimerization-Independent Mechanisms  

Science Journals Connector (OSTI)

...Source) used to obtain stably fluorescent cells as previously described...metastases Bright-field and fluorescent images of skeletal metastases...lens of vertebrates' ocular bulb (31). In these cells, growth...intracellular ROS. This event led to the direct activation of...

Mike R. Russell; Qingxin Liu; Hetian Lei; Andrius Kazlauskas; and Alessandro Fatatis

2010-05-15T23:59:59.000Z

72

Hypersensitivity of human and rodent Fanconi anemia (FA) cells to bystander  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Paul Wilson Paul Wilson Lawrence Livermore National Laboratory Abstract Fanconi anemia (FA) is a chromosomal instability and cancer predisposition syndrome characterized by developmental defects, progressive bone marrow failure, and cellular hypersensitivity to agents that induce DNA interstrand crosslinks and oxidative stress [1]. The disease is transmitted either as an autosomal-recessive or X-linked trait, and mutations in 13 FA genes have been identified in FA patients (with more likely to be discovered). Previously, we reported on the hypersensitivity of the isogenic Fancg-deficient Chinese hamster ovary (CHO) mutant KO40 for sister chromatid exchange (SCE) induction following low dose 3.86-MeV plutonium-238 α-particle irradiation where <1% of cell nuclei are hit.

73

Genetic Modification of Stem Cells for Improved Therapy of the Infarcted Myocardium  

Science Journals Connector (OSTI)

Janssens, S.; Dubois, C.; Bogaert, J.; Theunissen, K.; Deroose, C.; Desmet, W.; Kalantzi, M.; Herbots, L.; Sinnaeve, P.; Dens, J.; Maertens, J.; Rademakers, F.; Dymarkowski, S.; Gheysens, O.; Van Cleemput, J.; Bormans, G.; Nuyts, J.; Belmans, A.; Mortelmans, L.; Boogaerts, M.; Van de Werf, F.Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial Lancet 2006, 367, 113– 121 ... Janssens Stefan; Dubois Christophe; Bogaert Jan; Theunissen Koen; Deroose Christophe; Desmet Walter; Kalantzi Maria; Herbots Lieven; Sinnaeve Peter; Dens Joseph; Maertens Johan; Rademakers Frank; Dymarkowski Steven; Gheysens Olivier; Van Cleemput Johan; Bormans Guy; Nuyts Johan; Belmans Ann; Mortelmans Luc; Boogaerts Marc; Van de Werf Frans ...

Husnain Kh. Haider; Anique Mustafa; Yuliang Feng; Muhammad Ashraf

2011-05-18T23:59:59.000Z

74

E-Print Network 3.0 - acute lung infection Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

productive infection has been clearly demonstrated in lung 19 and in the aor- tic... be detected in the bone marrow 17, and the presence of latently infected cells...

75

E-Print Network 3.0 - angiogenic factors released Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Southern Illinois University Edwardsville Collection: Mathematics 44 Effect of chitosan particles and dexamethasone on human bone marrow stromal cell osteogenesis and...

76

Targeted Gene Deletion Demonstrates that Cell Adhesion MoleculeICAM-4 is Critical for Erythroblastic Island Formation  

SciTech Connect (OSTI)

Erythroid progenitors differentiate in erythroblastic islands, bone marrow niches composed of erythroblasts surrounding a central macrophage. Evidence suggests that within islands adhesive interactions regulate erythropoiesis and apoptosis. We are exploring whether erythroid intercellular adhesion molecule-4 (ICAM-4), animmunoglobulin superfamily member, participates in island formation. Earlier, we identified alpha V integrins as ICAM-4 counter receptors. Since macrophages express alpha V, ICAM-4 potentially mediates island attachments. To test this, we generated ICAM-4 knockout mice and developed quantitative, live cell techniques for harvesting intact islands and for reforming islands in vitro. We observed a 47 percent decrease in islands reconstituted from ICAM-4 null marrow compared to wild type. We also found a striking decrease in islands formed in vivo in knockout mice. Further, peptides that block ICAM-4 alpha V adhesion produced a 53-57 percent decrease in reconstituted islands, strongly suggesting that ICAM-4 binding to macrophage alpha V functions in island integrity. Importantly, we documented that alpha V integrin is expressed in macrophages isolated from erythro blastic islands. Collectively, these data provide convincing evidence that ICAM-4 is critical in erythroblastic island formation via ICAM-4/alpha V adhesion and also demonstrate that the novel experimental strategies we developed will be valuable in exploring molecular mechanisms of erythroblastic island formation and their functional role in regulating erythropoiesis.

Lee, Gloria; Lo, Annie; Short, Sarah A.; Mankelow, Tosti J.; Spring, Frances; Parsons, Stephen F.; Mohandas, Narla; Anstee, David J.; Chasis, Joel Anne

2006-02-15T23:59:59.000Z

77

Fracture, aging and disease in bone  

E-Print Network [OSTI]

separate during bone fracture. Nature Materials 4, 612 (on nonagenarians with hip fractures? Injury 30, 169 (1999).bone mass as predictors of fracture in a prospective study.

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

78

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Bioactive Glass Scaffolds for Bone Regeneration Print Wednesday, 28 September 2011 00:00 Natural materials are renowned for their...

79

Bone Surface and Whole Bone as Biomarkers for Acute Fluoride Exposure  

Science Journals Connector (OSTI)

......whole bone Fas a function oftime after the F doseswere tested for statistically significant differences by the Kruskal-Wallis test and Dunn's multiple comparison test. The correlation between bone surface and whole bone F concentrations......

Marília Afonso Rabelo Buzalaf; Elide Escolástico Caroselli; Juliane Guimarães de Carvalho; Rodrigo Cardoso de Oliveira; Vanessa Eid da Silva Cardoso; Gary Milton Whitford

2005-01-01T23:59:59.000Z

80

Collagen (NeuraGen®) nerve conduits and stem cells for peripheral nerve gap repair  

Science Journals Connector (OSTI)

Abstract Collagen nerve guides are used clinically for peripheral nerve defects, but their use is generally limited to lesions up to 3 cm. In this study we combined collagen conduits with cells as an alternative strategy to support nerve regeneration over longer gaps. In vitro cell adherence to collagen conduits (NeuraGen® nerve guides) was assessed by scanning electron microscopy. For in vivo experiments, conduits were seeded with either Schwann cells (SC), SC-like differentiated bone marrow-derived mesenchymal stem cells (dMSC), SC-like differentiated adipose-derived stem cells (dASC) or left empty (control group), conduits were used to bridge a 1 cm gap in the rat sciatic nerve and after 2-weeks immunohistochemical analysis was performed to assess axonal regeneration and SC infiltration. The regenerative cells showed good adherence to the collagen walls. Primary SC showed significant improvement in distal stump sprouting. No significant differences in proximal regeneration distances were noticed among experimental groups. dMSC and dASC-loaded conduits showed a diffuse sprouting pattern, while SC-loaded showed an enhanced cone pattern and a typical sprouting along the conduits walls, suggesting an increased affinity for the collagen type I fibrillar structure. NeuraGen® guides showed high affinity of regenerative cells and could be used as efficient vehicle for cell delivery. However, surface modifications (e.g. with extracellular matrix molecule peptides) of NeuraGen® guides could be used in future tissue-engineering applications to better exploit the cell potential.

Pietro G. di Summa; Paul J. Kingham; Corrado C. Campisi; Wassim Raffoul; Daniel F. Kalbermatten

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Constitutive and Induced Expression of Growth Factors in Normal and Chronic Phase Chronic Myelogenous Leukemia Ph1 Bone Marrow Stroma  

Science Journals Connector (OSTI)

...EMBO J., 5: 2529-2537. 1986. 27. Content. J., De Wit. L., Poupart, P.. Opdenakker. G.. Van Damme. J...Mosley. B., Larsen. A.. Cerretti. D. P.. Braedt. G.. Price. V.. 55. Gillis. S.. Henney. C. S.. Kronheim. S...

Meir Wetzler; Razelle Kurzrock; Kerry Taylor; Gary Spitzer; Hagop Kantarjian; Gabriella Baiocchi; Stella Ku; Jordan U. Gutterman; and Moshe Talpaz

1990-09-15T23:59:59.000Z

82

Abstract 3532: Antitumor activity of SR16388 on multiple myeloma targets factors needed for adaptation to bone marrow microenvironment  

Science Journals Connector (OSTI)

...Lidia Sambucetti 1 1Stanford Research Institute International, Menlo Park, CA. Multiple myeloma (MM) is the...angiogenesis and support their growth and survival. At SRI International, we have developed a steroidal anti-angiogenic...

Wan-Ru Chao; Dominic H. Dinh; Yihui Shi; Carol Hou; Barbara Sato; Carsten Alt; Nathan Collins; and Lidia Sambucetti

2011-04-15T23:59:59.000Z

83

Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells  

SciTech Connect (OSTI)

Highlights: •ESCRT-0 protein regulates the development of peripheral B-cells. •BCR expression on cell surface should be controlled by the endosomal-sorting system. •Hrs plays important roles in responsiveness to Ag stimulation in B lymphocytes. -- Abstract: Hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) is a vesicular sorting protein that functions as one of the endosomal-sorting proteins required for transport (ESCRT). Hrs, which binds to ubiquitinated proteins through its ubiquitin-interacting motif (UIM), contributes to the lysosomal transport and degradation of ubiquitinated membrane proteins. However, little is known about the relationship between B-cell functions and ESCRT proteins in vivo. Here we examined the immunological roles of Hrs in B-cell development and functions using B-cell-specific Hrs-deficient (Hrs{sup flox/flox};mb1{sup cre/+}:Hrs-cKO) mice, which were generated using a cre-LoxP recombination system. Hrs deficiency in B-cells significantly reduced T-cell-dependent antibody production in vivo and impaired the proliferation of B-cells treated in vitro with an anti-IgM monoclonal antibody but not with LPS. Although early development of B-cells in the bone marrow was normal in Hrs-cKO mice, there was a significant decrease in the number of the peripheral transitional B-cells and marginal zone B-cells in the spleen of Hrs-cKO mice. These results indicate that Hrs plays important roles during peripheral development and physiological functions of B lymphocytes.

Nagata, Takayuki [Department of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima 970-8551 (Japan) [Department of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima 970-8551 (Japan); Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575 (Japan); Murata, Kazuko, E-mail: murata-k@iwakimu.ac.jp [Department of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima 970-8551 (Japan)] [Department of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima 970-8551 (Japan); Murata, Ryo [Department of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima 970-8551 (Japan)] [Department of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima 970-8551 (Japan); Sun, Shu-lan [Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575 (Japan)] [Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575 (Japan); Saito, Yutaro; Yamaga, Shuhei [Department of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima 970-8551 (Japan)] [Department of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima 970-8551 (Japan); Tanaka, Nobuyuki; Tamai, Keiichi [Division of Immunology, Miyagi Cancer Research Institute, 47-1 Nodayama, Medeshima-Shiode, Natori 981-1293 (Japan)] [Division of Immunology, Miyagi Cancer Research Institute, 47-1 Nodayama, Medeshima-Shiode, Natori 981-1293 (Japan); Moriya, Kunihiko [Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8575 (Japan)] [Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8575 (Japan); Kasai, Noriyuki [Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575 (Japan)] [Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575 (Japan); Sugamura, Kazuo [Division of Immunology, Miyagi Cancer Research Institute, 47-1 Nodayama, Medeshima-Shiode, Natori 981-1293 (Japan)] [Division of Immunology, Miyagi Cancer Research Institute, 47-1 Nodayama, Medeshima-Shiode, Natori 981-1293 (Japan); Ishii, Naoto [Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575 (Japan)] [Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575 (Japan)

2014-01-10T23:59:59.000Z

84

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic...

85

Positive modulator of bone morphogenic protein-2  

DOE Patents [OSTI]

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

Zamora, Paul O. (Gaithersburg, MD); Pena, Louis A. (Poquott, NY); Lin, Xinhua (Plainview, NY); Takahashi, Kazuyuki (Germantown, MD)

2009-01-27T23:59:59.000Z

86

Treatment for Myeloma Bone Disease  

Science Journals Connector (OSTI)

...in the use of bone-seeking radiopharmaceuticals make these attractive therapeutic...26 Abildgaard N, Bentzen SM, Nielsen JL, Heickendorff...patients, correlation with TC-99M-sestaMIBI scintigraphy...Palermo S. Samarium-153 Sm-EDTMP and zoledronic acid...

Howard S. Yeh and James R. Berenson

2006-10-15T23:59:59.000Z

87

Mechanical regulation of signaling pathways in bone, William R. Thompson a,  

E-Print Network [OSTI]

Review Mechanical regulation of signaling pathways in bone, William R. Thompson a, , Clinton T A wide range of cell types depend on mechanically induced signals to enable appropriate physiological re- sponses. The skeleton is particularly dependent on mechanical information to guide the resident cell

88

Near-infrared emitting quantum dots for cellular and vascular fluorescent labeling in in vivo multiplexed imaging studies  

E-Print Network [OSTI]

In vivo multimodal, multiplexed microscopy allows real-time observation of hematopoietic cells, their stem and progenitor cells and metastatic cancer cells in their native bone marrow (BM) environment. Multiplexing has ...

Wu, Juwell Wendy

2011-01-01T23:59:59.000Z

89

Interplay effects between dose distribution quality and positioning accuracy in total marrow irradiation with volumetric modulated arc therapy  

SciTech Connect (OSTI)

Purpose: To evaluate the dosimetric consequences of inaccurate isocenter positioning during treatment of total marrow (lymph-node) irradiation (TMI-TMLI) using volumetric modulated arc therapy (VMAT).Methods: Four patients treated with TMI and TMLI were randomly selected from the internal database. Plans were optimized with VMAT technique. Planning target volume (PTV) included all the body bones; for TMLI, lymph nodes and spleen were considered into the target, too. Dose prescription to PTV was 12 Gy in six fractions, two times per day for TMI, and 2 Gy in single fraction for TMLI. Ten arcs on five isocenters (two arcs for isocenter) were used to cover the upper part of PTV (i.e., from cranium to middle femurs). For each plan, three series of random shifts with values between ?3 and +3 mm and three between ?5 and +5 mm were applied to the five isocenters simulating involuntary patient motion during treatment. The shifts were applied separately in the three directions: left–right (L-R), anterior–posterior (A-P), and cranial–caudal (C-C). The worst case scenario with simultaneous random shifts in all directions simultaneously was considered too. Doses were recalculated for the 96 shifted plans (24 for each patient).Results: For all shifts, differences <0.5% were found for mean doses to PTV, body, and organs at risk with volumes >100 cm{sup 3}. Maximum doses increased up to 15% for C-C shifted plans. PTV covered by the 95% isodose decreased of 2%–8% revealing target underdosage with the highest values in C-C direction.Conclusions: The correct isocenter repositioning of TMI-TMLI patients is fundamental, in particular in C-C direction, in order to avoid over- and underdosages especially in the overlap regions. For this reason, a dedicated immobilization system was developed in the authors' center to best immobilize the patient.

Mancosu, Pietro; Navarria, Piera; Reggiori, Giacomo; Tomatis, Stefano; Alongi, Filippo; Scorsetti, Marta [Department of Radiation Oncology, Humanitas Clinical and Research Center, Rozzano, Milan 20089 (Italy)] [Department of Radiation Oncology, Humanitas Clinical and Research Center, Rozzano, Milan 20089 (Italy); Castagna, Luca; Sarina, Barbara [Bone Marrow Transplantation Unit, Humanitas Clinical and Research Center, Rozzano, Milan 20089 (Italy)] [Bone Marrow Transplantation Unit, Humanitas Clinical and Research Center, Rozzano, Milan 20089 (Italy); Nicolini, Giorgia; Fogliata, Antonella; Cozzi, Luca [Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona 6500 (Switzerland)] [Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona 6500 (Switzerland)

2013-11-15T23:59:59.000Z

90

Digital electronic bone growth stimulator  

DOE Patents [OSTI]

The present invention relates to the electrical treatment of biological tissue. In particular, the present invention discloses a device that produces discrete electrical pulse trains for treating osteoporosis and accelerating bone growth. According to its major aspects and broadly stated, the present invention consists of an electrical circuit configuration capable of generating Bassett-type waveforms shown with alternative signals provide for the treatment of either fractured bones or osteoporosis. The signal generator comprises a quartz clock, an oscillator circuit, a binary divider chain, and a plurality of simple, digital logic gates. Signals are delivered efficiently, with little or no distortion, and uniformly distributed throughout the area of injury. Perferably, power is furnished by widely available and inexpensive radio batteries, needing replacement only once in several days. The present invention can be affixed to a medical cast without a great increase in either weight or bulk. Also, the disclosed stimulator can be used to treat osteoporosis or to strengthen a healing bone after the cast has been removed by attaching the device to the patient`s skin or clothing.

Kronberg, J.W.

1993-01-01T23:59:59.000Z

91

Evaluation of bone response to synthetic bone grafting material treated with argon-based atmospheric pressure plasma  

Science Journals Connector (OSTI)

Abstract Bone graft materials are utilized to stimulate healing of bone defects or enhance osseointegration of implants. In order to augment these capabilities, various surface modification techniques, including atmospheric pressure plasma (APP) surface treatment, have been developed. This in vivo study sought to assess the effect of APP surface treatment on degradation and osseointegration of Synthograft™, a beta-tricalcium phosphate (?-TCP) synthetic bone graft. The experimental (APP-treated) grafts were subjected to APP treatment with argon for a period of 60 s. Physicochemical characterization was performed by environmental scanning electron microscopy, surface energy (SE), and x-ray photoelectron spectroscopy analyses both before and after APP treatment. Two APP-treated and two untreated grafts were surgically implanted into four critical-size calvarial defects in each of ten New Zealand white rabbits. The defect samples were explanted after four weeks, underwent histological analysis, and the percentages of bone, soft tissue, and remaining graft material were quantified by image thresholding. Material characterization showed no differences in particle surface morphology and that the APP-treated group presented significantly higher SE along with higher amounts of the base material chemical elements on it surface. Review of defect composition showed that APP treatment did not increase bone formation or reduce the amount of soft tissue filling the defect when compared to untreated material. Histologic cross-sections demonstrated osteoblastic cell lines, osteoid deposition, and neovascularization in both groups. Ultimately, argon-based APP treatment did not enhance the osseointegration or degradation of the ?-TCP graft. Future investigations should evaluate the utility of gases other than argon to enhance osseointegration through APP treatment.

Bryan G. Beutel; Natalie R. Danna; Riddhi Gangolli; Rodrigo Granato; Lakshmiprada Manne; Nick Tovar; Paulo G. Coelho

2014-01-01T23:59:59.000Z

92

Bone Mineral Density in Women with Depression  

Science Journals Connector (OSTI)

...illness and the normal women were individually matched for age, body-mass index, and menstrual status; women with many of the risk factors associated with decreased bone mineral density were excluded; dual-energy x-ray absorptiometry was used to measure bone density at the spine, hip, and radius; and bone... Major depression is a complex disorder reflecting genetic, developmental, and environmental factors. Although its pathophysiology is not clearly understood, depression is associated with hypothalamic dysfunction — specifically, hypercortisolism, the ...

Michelson D.; Stratakis C.; Hill L.

1996-10-17T23:59:59.000Z

93

WRITTEN IN BONE: Bone Biographer's Casebook Douglas Owsley and Karin Bruwelheide  

E-Print Network [OSTI]

afflictions that would have made daily life miserable. In addition to dental disease and gout, his bones were

Mathis, Wayne N.

94

Composite bone substitutes prepared by two methods  

E-Print Network [OSTI]

Hydroxyapatite-polyethylene composites: effect of graftingof braded carbon/PEEK composite compression bone plates,”Koch, “Hydroxyapatite/SiO2 Composites via Freeze Casting for

Lee, Hoe Yun; Lee, Hoe Yun

2012-01-01T23:59:59.000Z

95

Ultrasound-Confirmed Frontal Bone Fracture  

E-Print Network [OSTI]

table--frontal sinus fractures. Facial Plast Surg Clin NorthConfirmed Frontal Bone Fracture Jeremy N. Johnson, DO Danielan isolated comminuted fracture of the left frontal sinus

Johnson, Jeremy N; Crandall, Stephen; Kang, Christopher S

2009-01-01T23:59:59.000Z

96

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure....

97

Effects of hydrolysis on dodecyl alcohol-modified bioactive glasses and PDLLA/modified bioactive glass composite films  

Science Journals Connector (OSTI)

In this cell culture experiment, the fifth passage of bone marrow mesenchymal stem cells from dogs (dMSC) was employed. dMSCs were isolated and...28]. Circular-shaped specimens with the diameter of 1 cm were cut ...

YanLing Zhou; Yuan Gao; Jiang Chang

2010-12-01T23:59:59.000Z

98

Introduction to Hematopoietic Growth Factors  

Science Journals Connector (OSTI)

A complex, inter-related, and multistep process called hematopoiesis controls the production and development of specific bone marrow cells...11...blood cells are produced in an adult human each day. The prolifera...

George Morstyn MBBS; PhD; FRACP…

2004-01-01T23:59:59.000Z

99

Exposure to supernatants of macrophages that phagocytized dead mesenchymal stem cells improves hypoxic cardiomyocytes survival  

Science Journals Connector (OSTI)

Objective To observe the impact of supernatants from macrophages that phagocytized dead \\{MSCs\\} (pM?) on the survival of hypoxic cardiomyocytes. Methods \\{MSCs\\} were isolated from bone marrow of mice and dead \\{MSCs\\} were harvested after 6 h hypoxia. Macrophages were obtained from thioglycolate-elicited peritoneal cavity. Macrophages and dead \\{MSCs\\} were co-cultured for 2 days in the presence or absence of LPS (1 ?g/ml). Cardiomyocytes obtained from neonatal mice were exposed to various medium including supernatants from pM?. MTT cell proliferation assay and mitochondria membrane potential were used to evaluate the viability of cardiomyocytes. Cytokines and chemokines (TNF-?, IFN-?, IL-6, IL-12, PGE2, VEGF-?, Ang-1, KGF, IGF-1, PDGF-BB, and EPO) in culture medium of macrophages, \\{MSCs\\} and pM? were detected by ELISA and Real-Time-PCR. Results: phagocytic activity of macrophages to dMSC was significantly enhanced by LPS. PGE2, VEGF-?, Ang-1, KGF, IGF-1, PDGF-BB, and EPO levels were significantly increased in supernatants of pM?. Exposure to supernatants of pM? significantly improved viability and survival time of hypoxic cardiomyocytes. Conclusion Exposure to supernatants of pM? significantly improved viability and survival time of hypoxic cardiomyocytes, which might be linked to increased cytokines and chemokines secretion by pM?.

Wenbin Lu; Cong Fu; Li Song; Yuyu Yao; XiaoLi Zhang; Zhong Chen; Yongjun Li; Genshan Ma; Chengxing Shen

2013-01-01T23:59:59.000Z

100

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bioactive Glass Scaffolds for Bone Regeneration Bioactive Glass Scaffolds for Bone Regeneration Print Wednesday, 28 September 2011 00:00 Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

102

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

103

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

104

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

105

Structural Analysis of Human and Bovine Bone for Development of Synthetic Materials  

E-Print Network [OSTI]

bones, as well as mimicking nature by developing a synthetic material to repair bones. Experimentally, bovine bone, tumor-free human bone, and cancerous human bone were studied via the small scale mechanical loading test. Failure analysis was conducted...

Jang, Eunhwa

2012-10-19T23:59:59.000Z

106

Effect of Synthetic Marrow on Synthetic Open-Cell Foam Vertebrae  

E-Print Network [OSTI]

Figure 12: Material “B” average modulus (star indicates significance in p-value of t-test). ... 30 Figure 13: Material "B" average ultimate stress. .................................................................................... 31 Figure 14...: Material “B” average ultimate strain (stars indicate significant p-values from t- test). .................................................................................................................................................. 33 Figure 15...

Good, Brian Victor

2011-12-31T23:59:59.000Z

107

Application of synchrotron radiation computed microtomography for quantification of bone microstructure in human and rat bones  

SciTech Connect (OSTI)

This work aims to evaluate histomorphometric quantification by synchrotron radiation computed microto-mography in bones of human and rat specimens. Bones specimens are classified as normal and pathological (for human samples) and irradiated and non-irradiated samples (for rat ones). Human bones are specimens which were affected by some injury, or not. Rat bones are specimens which were irradiated, simulating radiotherapy procedures, or not. Images were obtained on SYRMEP beamline at the Elettra Synchrotron Laboratory in Trieste, Italy. The system generated 14 {mu}m tomographic images. The quantification of bone structures were performed directly by the 3D rendered images using a home-made software. Resolution yielded was excellent what facilitate quantification of bone microstructures.

Parreiras Nogueira, Liebert; Barroso, Regina Cely; Pereira de Almeida, Andre; Braz, Delson; Almeida, Carlos Eduardo de; Borba de Andrade, Cherley; Tromba, Giuliana [Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro (Brazil); Physics Institute / State University of Rio de Janeiro, 20550-900, Rio de Janeiro (Brazil); Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro (Brazil); Laboratory of Radiological Sciences / State University of Rio de Janeiro, Rio de Janeiro (Brazil); Sincrotrone Trieste SCpA, Strada Statale S.S. 14 km 163.5, 34012 Basovizza, Trieste (Italy)

2012-05-17T23:59:59.000Z

108

E-Print Network 3.0 - autologous cell therapy Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2009 447 The new england Summary: of nonmyeloablative chemo- therapy followed by an infusion of autologous hematopoietic stem cells that had been trans... autologous CD34+ bone...

109

Steel Factorand c-kit Regulate Cell-Matrix Adhesion By Tatsuo Kinashi and Timothy A. Springer  

E-Print Network [OSTI]

Steel Factorand c-kit Regulate Cell-Matrix Adhesion By Tatsuo Kinashi and Timothy A. Springer Steel (SI) and white spotting (W) loci encode steel factor (c-kitligand) andthe c-kit tyrosine kinase adhesionusingbone marrow-derived mast cells as a model system.Steel factor stimulatesmast cells to bind

Springer, Timothy A.

110

Fracture, aging and disease in bone  

E-Print Network [OSTI]

by enhancing the materials resistance to microstructuralgrowth resistance of microcracking brittle materials. J. Am.resistance to fracture of the Page 4 Fracture, Aging and Disease in Bone underlying material.

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

111

E-Print Network 3.0 - adaptive bone remodelling Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

various sites and involves resorption by osteoclast, followed... mineral density and bone micro- architecture. Our paper focuses on bone microstructure and remodeling... in bone...

112

E-Print Network 3.0 - areal bone mineral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(DXA)-derived areal bone mineral density (BMD) and reductions in vertebral fracture incidence... than the bone volume fraction (mineralized bone volumebulk volume).12...

113

E-Print Network 3.0 - assessing bone mass Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

on assessment of bone mass... the amount of bone mass and predict the risk for fracture. However, the cur- rently available techniques... - tive assessment of bone ......

114

Abstract 4328: Marrow stromal cells promote mitochondrial energy metabolism in primary CLL cells without impacting cellular proliferation  

Science Journals Connector (OSTI)

...meeting-abstract Prevention Research Poster Presentations...Late-Breaking Abstracts Late-Breaking...Dietary energy balance modulation...Dietary energy balance modulation...factor-1. [abstract]. In: Proceedings...for Cancer Research; 2013 Apr...

Hima Venkata Vangapandu; Kumudha Balakrishnan; William G. Wierda; Michael J. Keating; Christine M. Stellrecht; and Varsha Gandhi

2014-10-01T23:59:59.000Z

115

CARBONATE STABLE ISOTOPES | Terrestrial Teeth and Bones  

Science Journals Connector (OSTI)

Teeth and bones of fossil vertebrates can preserve a record of Quaternary terrestrial environments in the form of isotopic compositions of carbon (13C/12C), nitrogen (15N/14N), and oxygen (18O/16O). These isotopic signatures in teeth and bones have yielded valuable information on the extent of savanna environments under tropical climates, on the ancient levels of aridity, on the spread of dense forests at the beginning of the Holocene, and on the paleodiet of hominids and their associated fauna.

H. Bocherens; D.G. Drucker

2007-01-01T23:59:59.000Z

116

CARBONATE STABLE ISOTOPES | Terrestrial Teeth and Bones  

Science Journals Connector (OSTI)

Abstract Teeth and bones of fossil vertebrates can preserve a record of Quaternary terrestrial environments in the form of the isotopic compositions of carbon (13C/12C), nitrogen (15N/14N), and oxygen (18O/16O). These isotopic signatures in teeth and bones have yielded valuable information on the extent of savanna environments under tropical climates, on the ancient levels of aridity, on the spread of dense forests at the beginning of the Holocene, and on the paleodiet of Hominids and their associated fauna.

H. Bocherens; D.G. Drucker

2013-01-01T23:59:59.000Z

117

Mechanical bone strength in the proximal tibia  

E-Print Network [OSTI]

. Hvid I, Jansen J: Mechanical strength of the tibial resection surface in total knee replacement. Eng Med 12:173-176, 1983 9. Hvid I, Jansen J: Cancellous bone strength at the proximal human tibia. Eng Med 13:21-25, 1984 28 10. Hvid I, Jansen J.... Hvid I, Jansen J: Mechanical strength of the tibial resection surface in total knee replacement. Eng Med 12:173-176, 1983 9. Hvid I, Jansen J: Cancellous bone strength at the proximal human tibia. Eng Med 13:21-25, 1984 28 10. Hvid I, Jansen J...

Prommin, Danu

2012-06-07T23:59:59.000Z

118

Research Finds Vitamin D Deficiency Affects Bone Quality  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of vitamin D, the "sunshine vitamin," have been previously linked to the health and fracture risk of human bone on the basis of low calcium intake and reduced bone density. The...

119

Vascular Homeostasis Regulators, Edn1 and Agpt2, are Upregulated as a Protective Effect of Heat-treated Zinc Yeast in Irradiated Murine Bone Marrow  

Science Journals Connector (OSTI)

......damage postirradiation in humans following a nuclear plant-related accident or in the event of nuclear terrorism. ACKNOWLEDGEMENTS We thank Dr. Makoto...Grant from Special Accounts for Electric Power Development Acceleration Measures. REFERENCES......

Megumi Ueno; Kaori Imadome; Mayumi Iwakawa; Kazunori Anzai; Nobuo Ikota; Takashi Imai

2010-09-01T23:59:59.000Z

120

Building Strong Bones: Calcium Information for Health Care Providers  

E-Print Network [OSTI]

intake of calcium.2 You can help children achieve lifelong bone health by talking to parents and young of calcium necessary for optimal bone development. Research suggests many parents don't know that children to three decades of life ·The rate at which bone is lost in the later years Although the consequences

Rau, Don C.

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Bones as biofuel: a review of whale bone composition with implications for deep-sea biology and palaeoanthropology  

Science Journals Connector (OSTI)

...Review articles 1001 60 144 69 Bones as biofuel: a review of whale bone composition with...first attempts to quantify the enormous biofuel reserves of these giant creatures. The...smaller fatty acids. 3. Whale bones as biofuel These data have been unnoticed for half...

2011-01-01T23:59:59.000Z

122

Celebrating Black History Month with DOE's Sheri Bone | Department of  

Broader source: Energy.gov (indexed) [DOE]

with DOE's Sheri Bone with DOE's Sheri Bone Celebrating Black History Month with DOE's Sheri Bone February 9, 2011 - 2:04pm Addthis Sheri Bone. | File photo. Sheri Bone. | File photo. Ebony Meeks Former Assistant Press Secretary, Office of Public Affairs Throughout the month of February, we're introducing some remarkable African Americans who are working to advance the President's clean energy agenda and help the Department of Energy achieve its mission. This week we're profiling Sheri Bone who is Senior Project Director, Office of Nuclear Materials Integration, National Nuclear Security Administration. Sheri Bone Question: What is your key responsibility? SB: I'm responsible for developing the Department of Energy's strategic plan for nuclear materials. This means directing and leading a team of

123

Adaptive scapula bone remodeling computational simulation: Relevance to regenerative medicine  

SciTech Connect (OSTI)

Shoulder arthroplasty success has been attributed to many factors including, bone quality, soft tissue balancing, surgeon experience, and implant design. Improved long-term success is primarily limited by glenoid implant loosening. Prosthesis design examines materials and shape and determines whether the design should withstand a lifetime of use. Finite element (FE) analyses have been extensively used to study stresses and strains produced in implants and bone. However, these static analyses only measure a moment in time and not the adaptive response to the altered environment produced by the therapeutic intervention. Computational analyses that integrate remodeling rules predict how bone will respond over time. Recent work has shown that subject-specific two- and three dimensional adaptive bone remodeling models are feasible and valid. Feasibility and validation were achieved computationally, simulating bone remodeling using an intact human scapula, initially resetting the scapular bone material properties to be uniform, numerically simulating sequential loading, and comparing the bone remodeling simulation results to the actual scapula’s material properties. Three-dimensional scapula FE bone model was created using volumetric computed tomography images. Muscle and joint load and boundary conditions were applied based on values reported in the literature. Internal bone remodeling was based on element strain-energy density. Initially, all bone elements were assigned a homogeneous density. All loads were applied for 10 iterations. After every iteration, each bone element’s remodeling stimulus was compared to its corresponding reference stimulus and its material properties modified. The simulation achieved convergence. At the end of the simulation the predicted and actual specimen bone apparent density were plotted and compared. Location of high and low predicted bone density was comparable to the actual specimen. High predicted bone density was greater than actual specimen. Low predicted bone density was lower than actual specimen. Differences were probably due to applied muscle and joint reaction loads, boundary conditions, and values of constants used. Work is underway to study this. Nonetheless, the results demonstrate three dimensional bone remodeling simulation validity and potential. Such adaptive predictions take physiological bone remodeling simulations one step closer to reality. Computational analyses are needed that integrate biological remodeling rules and predict how bone will respond over time. We expect the combination of computational static stress analyses together with adaptive bone remodeling simulations to become effective tools for regenerative medicine research.

Sharma, Gulshan B., E-mail: gbsharma@ucalgary.ca [Emory University, Department of Radiology and Imaging Sciences, Spine and Orthopaedic Center, Atlanta, Georgia 30329 (United States); University of Pittsburgh, Swanson School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213 (United States); University of Calgary, Schulich School of Engineering, Department of Mechanical and Manufacturing Engineering, Calgary, Alberta T2N 1N4 (Canada); Robertson, Douglas D., E-mail: douglas.d.robertson@emory.edu [Emory University, Department of Radiology and Imaging Sciences, Spine and Orthopaedic Center, Atlanta, Georgia 30329 (United States); University of Pittsburgh, Swanson School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213 (United States)

2013-07-01T23:59:59.000Z

124

Local drug delivery for enhancing fracture healing in osteoporotic bone  

Science Journals Connector (OSTI)

Abstract Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an osteoporotic fracture is challenging due to the decreased strength of the surrounding bone and suboptimal healing capacity, predisposing both to fixation failure and non-union. Whereas a systemic osteoporosis treatment acts slowly, local release of osteogenic agents in osteoporotic fracture would act rapidly to increase bone strength and quality, as well as to reduce the bone healing period and prevent development of a problematic non-union. The identification of agents with potential to stimulate bone formation and improve implant fixation strength in osteoporotic bone has raised hope for the fast augmentation of osteoporotic fractures. Stimulation of bone formation by local delivery of growth factors is an approach already in clinical use for the treatment of non-unions, and could be utilized for osteoporotic fractures as well. Small molecules have also gained ground as stable and inexpensive compounds to enhance bone formation and tackle osteoporosis. The aim of this paper is to present the state of the art on local drug delivery in osteoporotic fractures. Advantages, disadvantages and underlying molecular mechanisms of different active species for local bone healing in osteoporotic bone are discussed. This review also identifies promising new candidate molecules and innovative approaches for the local drug delivery in osteoporotic bone.

Laura Kyllönen; Matteo D’Este; Mauro Alini; David Eglin

2014-01-01T23:59:59.000Z

125

Is pelvic bone mineral content assessed through dual energy X-ray absorptionmetry an appropriate anatomical area for bone mass estimation in women?  

Science Journals Connector (OSTI)

Bibliographic references seem very controversill regarding the most appropriate anatomical area for bone mass estimation. Since some overlapping in the different bone mass measurements among normal and osteopo...

Prof. Dr. H. Rico; M. Revilla; E. R. Hernández; L. F. Villa…

1992-12-01T23:59:59.000Z

126

Intravital Microscopy Reveals Novel Antivascular and Antitumor Effects of Endostatin Delivered Locally by Alginate-encapsulated Cells  

Science Journals Connector (OSTI)

...San Diego, CA 1167 Cell adhesion, proteolytic degradation of extracellular matrix and cell migration are interrelated processes responsible for the invasion and metastasis of cancer. In prostate cancer, androgen-independence and bone...

Tracy-Ann Read; Mohammed Farhadi; Rolf Bjerkvig; Bjørn Reino Olsen; Anne Mari Rokstad; Peter C. Huszthy; and Peter Vajkoczy

2001-09-15T23:59:59.000Z

127

Bone Cancer Rates in Dinosaurs Compared with Modern Vertebrates  

E-Print Network [OSTI]

Data on the prevalence of bone cancer in dinosaurs is available from past radiological examination of preserved bones. We statistically test this data for consistency with rates extrapolated from information on bone cancer in modern vertebrates, and find that there is no evidence of a different rate. Thus, this test provides no support for a possible role of ionizing radiation in the K-T extinction event.

L. C. Natarajan; A. L. Melott; B. M. Rothschild; L. D. Martin

2007-10-16T23:59:59.000Z

128

Blood Circulatory System The circulatory system consists of  

E-Print Network [OSTI]

resulting from too few RBC's or hemoglobin that causes a run-down feeling Sickle-Cell Disease Sickle-cell sickle-shaped red blood cells that tend to rupture as they pass through the narrow capillaries. Disorders elements: produced in red bone marrow Red blood cells/erythrocytes (RBC) White blood cells

Cochran-Stafira, D. Liane

129

On nano size structures for enhanced bone formation.  

E-Print Network [OSTI]

??Purpose The general aim of the present thesis was to investigate early bone response to titanium implants modified with nano size structures. Therefore, 1. a… (more)

Meirelles, Luiz

2007-01-01T23:59:59.000Z

130

Aging and Fracture of Human Cortical Bone and Tooth Dentin  

E-Print Network [OSTI]

Mechanistic aspects of fracture and R-curve behavior inof failure of solid biomaterials and bone: `fracture' and `pre- fracture' toughness. Materials Science and Engineering:

Ager III, Joel W.

2008-01-01T23:59:59.000Z

131

E-Print Network 3.0 - acute bone crises Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mography. Bone... Subchondral Bone Analyses by Micro-Computed Tomography Catherine Marchand, Ph.D.,1 Hongmei Chen, Ph.D.,1... to analyze subchondral bone features below treated...

132

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

133

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

134

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Irradiation Effects on Human Cortical Bone Fracture Behavior Irradiation Effects on Human Cortical Bone Fracture Behavior Print Wednesday, 28 July 2010 00:00 Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

135

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

136

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

137

E-Print Network 3.0 - adam12-s stimulates bone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and computer... design (dimensions, profile shape and material properties) on the load sharing with adjacent bone... and consequent bone resorption was tested, using a set of...

138

Supercritical carbon dioxide-processed resorbable polymer nanocomposites for bone graft substitute applications.  

E-Print Network [OSTI]

?? Numerous clinical situations necessitate the use of bone graft materials to enhance bone formation. While autologous and allogenic materials are considered the gold standards… (more)

Baker, Kevin

2011-01-01T23:59:59.000Z

139

E-Print Network 3.0 - alveolar bone defects Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

de mathmatiques Collection: Mathematics 30 Evaluation of trabecular bone patterns on dental radiographic images: influence of cortical bone. Summary: , G.J., "An investigation...

140

E-Print Network 3.0 - aspirate bone graft Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

-based implants for bone reconstruction and repair. We have developed HA-coated carbon-fiber polymer composites... that match bone's elastic modulus and show advantageous in...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

E-Print Network 3.0 - artificial bone substitute Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales Summary: to its biomedical significance, bone has been used...

142

E-Print Network 3.0 - affecting bone mineral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of remodeling on the mineralization of bone... of therapies that reduce the risk of fracture, increase bone mineral density or change the biochemical markers... mass and...

143

E-Print Network 3.0 - activity bone mineral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of remodeling on the mineralization of bone... of therapies that reduce the risk of fracture, increase bone mineral density or change the biochemical markers... mass and...

144

E-Print Network 3.0 - adsorbed bone sialoprotein Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mass Philipp J. Thurner a... 2010 Edited by: D. Burr Keywords: Osteopontin Rodent Fracture toughness Bone matrix properties... Mineralization The ability of bone to resist...

145

E-Print Network 3.0 - adverse events bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by Explorit Topic List Advanced Search Sample search results for: adverse events bone Page: << < 1 2 3 4 5 > >> 1 Mechanoregulated bone adaptation in osteoarthritis This...

146

Computational modelling of T-cell formation kinetics: output regulated by initial proliferation-linked deferral of developmental competence  

Science Journals Connector (OSTI)

...marrow-derived progenitors enter the thymus of an adult...our models validate the search for its molecular basis...At time zero, n cells enter the DN1pre compartment...11) best models in terms of G, the number of generations...11) best models in terms of G, the number of generations...

2013-01-01T23:59:59.000Z

147

Comparison of physical, chemical and cellular responses to nano- and micro-sized calcium silicate/poly(?-caprolactone) bioactive composites  

Science Journals Connector (OSTI)

...bone marrow-derived stromal cells on akermanite-bioactive ceramics. Biomaterials...Chang, W Zhai, S Ni, and J WangPorous akermanite scaffolds for bone tissue engineering...and J WangIn vitro bioactivity of akermanite ceramics. J. Biomed. Mater. Res...

2008-01-01T23:59:59.000Z

148

Patients with Patellofemoral Pain Exhibit Elevated Bone Metabolic Activity at the Patellofemoral Joint  

E-Print Network [OSTI]

for bone mineral,10 are injected intravenously. The 18 F fluoride ions exchange with hydroxl ions in bone and pain. Technetium-99m hydroxymethylene diphosphonate (Tc-99m MDP) bone scintigraphy previ- ously bone metabolic activity. In this imaging technique, 18 F fluoride ions, which have a high affinity

Delp, Scott

149

Patients with Patellofemoral Pain Exhibit Elevated Bone Metabolic Activity at the Patellofemoral Joint  

E-Print Network [OSTI]

for bone mineral,10 are injected intravenously. The 18 F fluoride ions exchange with hydroxl ions in bone stress and pain. Technetium-99m hydroxymethylene diphosphonate (Tc-99m MDP) bone scintigraphy previ bone metabolic activity. In this imaging technique, 18 F fluoride ions, which have a high affinity

Delp, Scott

150

How Tough is Human Cortical Bone? In-Situ Measurements on Realistically Short Cracks  

E-Print Network [OSTI]

growth resistance of microcrakcing brittle materials. J. Am.materials (including bone), invariably results in resistance-

Koester, K. J.

2008-01-01T23:59:59.000Z

151

Osseous penetration rate into implants pretreated with bone cement  

Science Journals Connector (OSTI)

The titanium bone growth chamber consists of two titanium disks held together by two screws. At the level of the intersection between the disks, a 1 mm wide canal penetrates the implant. After implantation, in e....

T. Albrektsson

1984-01-01T23:59:59.000Z

152

Compact biomedical pulsed signal generator for bone tissue stimulation  

DOE Patents [OSTI]

An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

Kronberg, J.W.

1993-06-08T23:59:59.000Z

153

Compact biomedical pulsed signal generator for bone tissue stimulation  

DOE Patents [OSTI]

An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

Kronberg, James W. (108 Independent Blvd., Aiken, SC 29801)

1993-01-01T23:59:59.000Z

154

Evaluation of radionuclide bone-imaging for the early detection of sepsis in a model of equine neonatal osteomyelitis  

E-Print Network [OSTI]

method of detecting bone abnormalities. The two main factors determining the degree of radiopharmaceutical uptake in bones, and thereby assessing the functional integrity of bone, have been identified as bone blood flow and bone turnover rates.... The resultant infection and induced metabolic changes should produce a positive Technetium-99m MDP ( Tc-MDP) 99m bone scan, a positive scan using Indium-111-oxine labeled leukocytes and radiographic changes characterized by decreased bone density . Seven...

Taylor, James Rutledge

1986-01-01T23:59:59.000Z

155

Trabecular bone dosimetry using a Monte Carlo code  

E-Print Network [OSTI]

The nuclear medicine community needs radiation ~ dose estimates to patients who are administered radiopharmaceuticals for therapy or diagnosis. These estimates should be as accurate as possible for any organ, and especially for the bone since the bone... of Nuclear Medicine formed a committee to fulfill the needs of the nuclear medicine community to determine the radiation absorbed dose to patients who are athninistered radiopharmaceuticals. The objectives of the Medical Internal Radiation Dose Committee...

Zuzarte de Mendonca, Anne

1993-01-01T23:59:59.000Z

156

Ibuprofen Administered Pre- or Post- Simulated Resistance Exercise Training Does Not Diminsh Gains in Bone Formation or Bone Mass  

E-Print Network [OSTI]

Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to suppress bone formation when administered before, but not if administered after, an acute bout of mechanical load in rats. The NSAID ibuprofen inhibits cyclooxygenase-2 enzyme...

Cunningham, David

2012-02-14T23:59:59.000Z

157

Histologic Comparison of Regenerate Bone Produced from Dentate Versus Edentulous Transport Discs in Bone Transport Distraction Osteogenesis  

E-Print Network [OSTI]

i HISTOLOGIC COMPARISON OF REGENERATE BONE PRODUCED FROM DENTATE VERSUS EDENTULOUS TRANSPORT DISCS IN BONE TRANSPORT DISTRACTION OSTEOGENESIS A Thesis by CARLOS SEVILLA GAITÁN Submitted to The Office of Graduate and Professional Studies... Paul Dechow Head of Department, William W. Nagy December 2013 Major Subject: Oral Biology Copyright 2013 Carlos Sevilla Gaitan ii ABSTRACT Purpose: The purpose of this research was to quantify the number of blood vessels...

Sevilla Gaitan, Carlos

2013-12-10T23:59:59.000Z

158

Mineralized and osteoid tissue from dental pulp stem cells on micro-arc oxidation titanium in vitro  

Science Journals Connector (OSTI)

The presence of insufficient bone volume affects the implant healing and success. The aim of this study was to evaluate osteogenic capacity of dental pulp stem cells (DPSCs) on micro-arc oxidation (MAO) titanium ...

Yi Huang ? ?; Ting Chang ? ?; Cheng Yang ? ?…

2012-08-01T23:59:59.000Z

159

Modeling marrow damage from response data: Morphallaxis from radiation biology to benzene toxicity  

SciTech Connect (OSTI)

Consensus principles from radiation biology were used to describe a generic set of nonlinear, first-order differential equations for modeling of toxicity-induced compensatory cell kinetics in terms of sublethal injury, repair, direct killing, killing of cells with unrepaired sublethal injury, and repopulation. This cellular model was linked to a probit model of hematopoietic mortality that describes death from infection and/or hemorrhage between {approximately} 5 and 30 days. Mortality data from 27 experiments with 851 doseresponse groups, in which doses were protracted by rate and/or fractionation, were used to simultaneously estimate all rate constants by maximum-likelihood methods. Data used represented 18,940 test animals distributed according to: (mice, 12,827); (rats, 2,925); (sheep, 1,676); (swine, 829); (dogs, 479); and (burros, 204). Although a long-term, repopulating hematopoietic stem cell is ancestral to all lineages needed to restore normal homeostasis, the dose-response data from the protracted irradiations indicate clearly that the particular lineage that is ``critical`` to hematopoietic recovery does not resemble stem-like cells with regard to radiosensitivity and repopulation rates. Instead, the weakest link in the chain of hematopoiesis was found to have an intrinsic radioresistance equal to or greater than stromal cells and to repopulate at the same rates. Model validation has been achieved by predicting the LD{sub 50} and/or fractional group mortality in 38 protracted-dose experiments (rats and mice) that were not used in the fitting of model coefficients.

Jones, T.D.; Morris, M.D.; Hasan, J.S.

1995-12-01T23:59:59.000Z

160

Common variants in the region around Osterix are associated with bone mineral density and growth in childhood  

E-Print Network [OSTI]

Peak bone mass achieved in adolescence is a determinant of bone mass in later life. In order to identify genetic variants affecting bone mineral density (BMD), we performed a genome-wide association study of BMD and related ...

Peltonen, Leena

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Bone breakage in laying hens as affected by dietary supplements  

E-Print Network [OSTI]

BONE BREAKAGE IN LAYING HENS AS AFFECTED BY DIETARY SUPPLEMENTS A Thesis by DAVID JOE MOORE Submitted to the Graduate College of Texas Al!M University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE August 1975... Major Subject: Poultry Science (Physiology) BONE BREAKAGE IN LAYING HENS AS AFFECTED BY DIETARY SUPPLEMENTS A Thesis by DAVID JOE MOORE Approved as to style and content by: Chairman of Comm' ee ad o Department) Member Member '7 I ls&wr g ~, /0...

Moore, David Joe

1975-01-01T23:59:59.000Z

162

E-Print Network 3.0 - attenuates bone cancer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: attenuates bone cancer Page: << < 1 2 3 4 5 > >> 1 Questions and Answers About Bone Cancer...

163

Processing of bone samples for the determination of ultra low-levels of uranium and plutonium  

Science Journals Connector (OSTI)

We have developed cleanroom compatible techniques for processing bone samples for ... dried and ashed in quartz crucibles placed inside cleanroom compatible thermal ashing furnaces. The bone ash...238U and 8 femt...

D. W. Efurd; R. E. Steiner; S. P. LaMont…

2006-09-01T23:59:59.000Z

164

Quantitative assessment of bone mineral content in dental radiography —Methodology and clinical usefulness  

Science Journals Connector (OSTI)

Various techniques have been developed for measuring bone mineral content in medical examination and treatment these days1–6). In the dento-maxilo-facial region, mandibular bone mineral content has been investiga...

Takenori Noikura

1996-12-01T23:59:59.000Z

165

E-Print Network 3.0 - air bone particles Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 3 4 5 > >> 1 Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone Summary: of trabecular bone Georg E. Fantnera,*, Henrik...

166

Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery  

Science Journals Connector (OSTI)

...promote the bone regeneration process. mesoporous bioceramics...accelerating the healing process. Thus, the design, development and commercialization of bioactive and biodegradable...elements play key roles in the processes that promote bone formation...

2012-01-01T23:59:59.000Z

167

Triple-Energy X-Ray Absorptiometry for Determination of the Bone Mineral Content in Vivo  

Science Journals Connector (OSTI)

Dual-energy X-ray absorptiometry (DXA) is a ... method for the determination of the bone mineral content in vivo. It has a high precision ... bone. The present work describes a triple-energy X-ray absorptiometry ...

Janos Szücs; Ragnar Jonson; Tommy Hansson

1993-01-01T23:59:59.000Z

168

Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins  

E-Print Network [OSTI]

Current treatment of bone defects due to trauma, cancer, or degenerative spine diseases involves the implantation of a bone graft. Autografts, which are harvested from the patient's own body, are associated with problems ...

Yong, Tseh-Hwan

2005-01-01T23:59:59.000Z

169

Visualizing biointerfaces in three dimensions: electron tomography of the bone–hydroxyapatite interface  

Science Journals Connector (OSTI)

...to three-dimensional analysis is becoming standard practice...routine three-dimensional analysis...biomaterial-bone interfaces by other...bone-scaffold interface and using...a three-dimensional reconstruction...tilt series measuring 320 260 70...

2010-01-01T23:59:59.000Z

170

E-Print Network 3.0 - acid reduces bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

properties in dog rib. J Bone... the Quality of Bone Tissue Stefan Judex, PhD*, Steve Boyd, PhD, Yi-Xian Qin, PhD, Lisa Miller, PhD, Ralph... is to withstand the loads and...

171

Bone Canonical WNT/B-Catenin Signaling in Models of Reduced Microgravity  

E-Print Network [OSTI]

BONE CANONICAL WNT/?-CATENIN SIGNALING IN MODELS OF REDUCED MICROGRAVITY A Dissertation by BRANDON RICHARD MACIAS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... Copyright 2012 Brandon Richard Macias ii ABSTRACT Human exposure to reduced weightbearing results in bone loss. The rate of bone loss during microgravity exposure is similar to that of a post-menopausal women. In fact, the maintenance of bone mass...

Macias, Brandon 1979-

2012-10-25T23:59:59.000Z

172

The consequence of late-onset alcohol abuse in aged bone: a histomorhometric analysis  

E-Print Network [OSTI]

of decreased intake and absorption, bone quality is negatively affected because of the decrease in nutrients that determine bone health (calcium, phosphorus, magnesium and vitamin D). Certain age-related physiological changes also promote osteoporosis... of ethanol treatment. Upon analysis of the bone content, they found that alcohol did not have an afFect on the bone mineral content such as calcium, magnesium, and phosphorus. Peng et. al. suggested that alcohol may induce an alteration...

Barker, Lisa Setchfield

2012-06-07T23:59:59.000Z

173

Fracture, aging, and disease in bone J.W. Ager III  

E-Print Network [OSTI]

Fracture, aging, and disease in bone J.W. Ager III Materials Sciences Division, Lawrence Berkeley-known increase with age in fracture risk of human bone is essential. This also represents a challenge from materials science and fracture mechanics viewpoints. Bone has a complex, hierarchical structure

Ritchie, Robert

174

Fracture resistance of human cortical bone across multiple length-scales at physiological strain rates  

E-Print Network [OSTI]

Fracture resistance of human cortical bone across multiple length-scales at physiological strain Accepted 22 March 2014 Available online 13 April 2014 Keywords: Bone Strain rate Fracture toughness Plasticity X-ray diffraction a b s t r a c t While most fracture-mechanics investigations on bone have been

Ritchie, Robert

175

Trabecular bone scales allometrically in mammals and birds  

Science Journals Connector (OSTI)

...1086/284325 ) 24 Silva, M. 1995 CRC Handbook of mammalian body masses. Boca Raton...Press. 25 Dunning, J. B. 2008 CRC handbook of avian body masses. 2nd edn. Boca...kg. We found that bone volume fraction does not scale substantially with animal size...

2011-01-01T23:59:59.000Z

176

Energy-dispersive X-ray microanalysis of the bone mineral content in human trabecular bone: A comparison with ICPES and neutron activation analysis  

Science Journals Connector (OSTI)

To evaluate the accuracy of bone mineral composition determination by electron microprobe analysis (EDX) the measurements have been compared to instrumental neutron activation analysis (INAA) and chemical anal...

K. Åkesson; M. D. Grynpas; R. G. V. Hancock; R. Odselius…

1994-09-01T23:59:59.000Z

177

Nukbone® promotes proliferation and osteoblastic differentiation of mesenchymal stem cells from human amniotic membrane  

SciTech Connect (OSTI)

Highlights: •Nukbone showed to be a good scaffold for adhesion, proliferation and differentiation of stem cells. •Nukbone induced osteoblastic differentiation of human mesenchymal stem cells. •Results showed that Nukbone offer an excellent option for bone tissue regeneration due to properties. -- Abstract: Bovine bone matrix Nukbone® (NKB) is an osseous tissue-engineering biomaterial that retains its mineral and organic phases and its natural bone topography and has been used as a xenoimplant for bone regeneration in clinics. There are not studies regarding its influence of the NKB in the behavior of cells during the repairing processes. The aim of this research is to demonstrate that NKB has an osteoinductive effect in human mesenchymal stem cells from amniotic membrane (AM-hMSCs). Results indicated that NKB favors the AM-hMSCs adhesion and proliferation up to 7 days in culture as shown by the scanning electron microscopy and proliferation measures using an alamarBlue assay. Furthermore, as demonstrated by reverse transcriptase polymerase chain reaction, it was detected that two gene expression markers of osteoblastic differentiation: the core binding factor and osteocalcin were higher for AM-hMSCs co-cultured with NKB in comparison with cultivated cells in absence of the biomaterial. As the results indicate, NKB possess the capability for inducing successfully the osteoblastic differentiation of AM-hMSC, so that, NKB is an excellent xenoimplant option for repairing bone tissue defects.

Rodríguez-Fuentes, Nayeli; Rodríguez-Hernández, Ana G. [Depto. Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510 (Mexico)] [Depto. Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510 (Mexico); Enríquez-Jiménez, Juana [Depto. Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), México City 14000 (Mexico)] [Depto. Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), México City 14000 (Mexico); Alcántara-Quintana, Luz E. [Subd. de Investigación, Centro Nacional de la Transfusión Sanguínea, Secretaria de Salud, Mexico City 07370 (Mexico)] [Subd. de Investigación, Centro Nacional de la Transfusión Sanguínea, Secretaria de Salud, Mexico City 07370 (Mexico); Fuentes-Mera, Lizeth [Depto. Biología Molecular e Histocompatibilidad, Hospital General “Dr. Manuel Gea González”, México City 4800 (Mexico)] [Depto. Biología Molecular e Histocompatibilidad, Hospital General “Dr. Manuel Gea González”, México City 4800 (Mexico); Piña-Barba, María C. [Depto. Materiales Metálicos y Cerámicos, Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico)] [Depto. Materiales Metálicos y Cerámicos, Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico); Zepeda-Rodríguez, Armando [Depto. Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico)] [Depto. Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico); and others

2013-05-10T23:59:59.000Z

178

Hypersensitivity of human and rodent Fanconi anemia (FA) cells to bystander  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

P.F. Wilson P.F. Wilson Brookhaven National Laboratory Abstract Fanconi anemia (FA) is a chromosomal instability and cancer predisposition syndrome characterized by developmental defects, progressive bone marrow failure, and cellular hypersensitivity to agents that induce DNA interstrand crosslinks and oxidative stress, including IR [1]. The disease is transmitted either as an autosomal-recessive or X-linked trait, and hypomorphic biallelic mutations in 15 FA and homologous recombinational repair (HRR) genes have been identified in FA patients (with more likely to be discovered). We have previously reported hypersensitivity of the isogenic fancg Chinese hamster ovary (CHO) mutant KO40 for sister chromatid exchange (SCE) induction following low-dose (<3 mGy) 3.86-MeV plutonium-238

179

Detection of bone disease in dogs by radioisotope scanning  

E-Print Network [OSTI]

, delayed union, and nonunion), osteomyelitis, degenerative arthritis, surgical osteotomy, i'ibrous dysplasia, osteochondromatosie, and growing epiphyses. Radioisotopic scanning has been reported 12 for studying the metabolism of Fluorine-18 in dogs 9..., ( 1962): 95-104. 2. Bauer, G. C. H. , and Smith, E. M. r Sr 85 Sointimetry in Osteoarthritis of the Knee. J . Nucl. Med. , 10, (Mar. , 1969): 109-116. Blau, M. , Nagler, W. , and Bender, M. A. : Fluorine ? 18. A New Isotope for Bone Scanning. J. Nucl...

Morris, Earl Louis

2012-06-07T23:59:59.000Z

180

Correction for Higgs et al., Bones as biofuel: a review of whale bone composition with implications for deep-sea biology and palaeoanthropology  

Science Journals Connector (OSTI)

...Journal is 2010 The Royal Society 22 March 2011 correction Corrections 1001 144 60 69 Correction for Higgs et al., Bones as biofuel: a review of whale bone composition with implications for deep-sea biology and palaeoanthropology Nicholas D. Higgs Crispin...

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Synchrotron  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Synchrotron Imaging Archaeopteryx specimens are important but extremely rare fossils. Due to their possession of both reptilian (jaws with teeth, long bony tail) and avian (feathered wings) characters, Archaeopteryx has been crucial in the development of Darwinian evolution. Despite their importance, no Archaeopteryx specimen has ever been chemically analyzed. This in large part may be explained by the analytical obstacles which preclude applying standard methods to such valuable specimens; destructive sampling is not an option and most non-destructive methods cannot handle large specimens. Furthermore, mapping using conventional methods is far too slow to enable chemical zonation to be reasonably determined. Mapping of trace element chemistry is of tremendous interest, however, because it opens a window into understanding several critical questions about Archaeopteryx in particular, and about fossil specimens in general. Preserved trace chemistry in bones and soft tissue may be remnants of the living organism, and therefore may give insight into life processes of extinct organisms. When mapping includes the embedding rock matrix, mass transfer between the fossil and the matrix can be constrained, hence giving information about mode of preservation. Chemical analysis can also resolve artefacts of the curation process. Finally, accurate chemical maps can also be useful for directing future work by highlighting regions that may be promising for other types of analysis including structural methods (CT, diffraction) or techniques that use other parts of the electromagnetic spectrum (infra-red).

182

3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone at the  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone 3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone at the Nanoscale Scientists studying osteoporosis and other skeletal diseases are interested in the 3D structure of bone and its responses to conditions such as weightlessness, radiation (of particular interest to astronauts) and vitamin D deficiency. The current gold standard, micro-computed tomography (micro-CT), provides 3D images of trabeculae, the small interior struts of bone tissue, and electron microscopy can provide nanometer resolution of thin tissue slices. Hard X-ray transmission microscopy has provided the first 3D view of bone structure within individual trabeculae on the nanoscale. figure 1 Figure 1 Micro-CT (left) shows trabecular structure inside of bone. Transmission X-ray microscopy (TXM; center and right) can reveal localized details of osteocyte lacunae and their processes.

183

Enhancement of Growth Performance and Bone Mineralization in Market Broilers through Dietary Enzymes  

E-Print Network [OSTI]

. In Experiment 1, a 35-day grow out trial was conducted to investigate the effect of three commercially available phytase enzymes on growth performance and bone mineralization in phosphorus deficient corn/soy based diets. Increasing the level of available... phosphorus (aP) in the control diets resulted in improved bird performance and bone ash data. The presence of dietary phytase in phosphorus deficient diets resulted in improvements in growth parameters and bone mineralization. Regression analysis...

Coppedge, Jacob Ryan

2012-02-14T23:59:59.000Z

184

E-Print Network 3.0 - autoimmune diabetic nod Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and signaling in bone marrow-derived macrophages at Summary: , University of Jordan, Amman, Jordan Keywords: autoimmunity, cytokines, diabetes complications,...

185

E-Print Network 3.0 - acute liquefaction necrosis Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to Different Bone Structure and Necrosis during Bone-Marrow Stimulation for Cartilage Repair Summary: apparent thermal necrosis. The conse- quences of these acute differences...

186

E-Print Network 3.0 - asymptomatic local bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Engineering ; Biology and Medicine 42 Science Highlight June 2010 Figure 1: Micro-CT (left) shows trabecular structure inside of bone. Transmission X-ray Summary: ....

187

E-Print Network 3.0 - apparent trabecular bone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

trabecular bone density in human... Trabecular ... Source: Gefen, Amit - Department of Biomedical Engineering, Tel Aviv University Collection: Engineering ; Biology and Medicine...

188

E-Print Network 3.0 - acetabular bone defect Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Journal of Arthroplasty Vol. 14 No. 7 1999 Case Report Summary: modular head and polyethylene liner. Bone defects were filled with morcellized allograft. Three months......

189

E-Print Network 3.0 - ancient human bones Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

, 2971-2977 first published online 3 June 20092762009Proc. R. Soc. B Summary: Shapiro, Reimer C. Dobberstein, ancient DNA in bone? Is amino acid racemization a useful...

190

E-Print Network 3.0 - alveolar bone loss Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

extended period of ossification. Most dermal bones begin ossification before ... Source: Smith, Kathleen K. - Department of Biology, Duke University Collection: Environmental...

191

E-Print Network 3.0 - anabolic bone hormone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in the Absence of Weight Bearing Can Enhance Trabecular Summary: two orders of magnitude smaller than those previously sug- gested, can be anabolic to bone when... ....

192

E-Print Network 3.0 - age-related bone loss Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 2 Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone Summary: . Modeling the mechanical behavior of vertebral...

193

E-Print Network 3.0 - animal bone collagen Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales Summary: of these cracks. 2005 Elsevier Ltd. All rights...

194

E-Print Network 3.0 - abnormally high bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by small intestine & promotes bone deposition... and Their Repairs stress fracture - break caused by abnormal ... Source: Morrell, Thomas E. - Department of Biology,...

195

E-Print Network 3.0 - affects bone parameters Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of bone quality will ultimately affect physical and morpho- logic parameters... fracture rates are most closely associated with ... Source: Rubin, Clinton T.- Department of...

196

E-Print Network 3.0 - absolutely normal bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

females (N 49). The data set consisted of bone biopsies from normal and vertebral fracture subjects... microradiographic studies of normal and oste- oporotic ... Source: Ecole...

197

E-Print Network 3.0 - anorganic bovine bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales Summary: , Hobbs LW, Spector M. The ultrastructure of...

198

E-Print Network 3.0 - abdomen bone growth Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

factor I and bone... . Genetic strategies for elucidat- ing insulin-like ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

199

E-Print Network 3.0 - attenuates bone cancer-induced Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

is incorrectly classified as bone when forming the linear attenuation coefficient image. We then investigate two... of attenuation coefficients of water (represent- ing...

200

E-Print Network 3.0 - agonist attenuates bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

unbalanced bone turnover that has been associated with a decreased number of ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

E-Print Network 3.0 - abnormal bone growth Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

@DIIT.UNICT.IT 1. INTRODUCTION Bone age assessment is a procedure frequently performed in pediatric radiology... . Based on a radiological examination of skeletal development of...

202

A study to optimize the macroscopic structure of bone pylons used in direct skeletal attachment systems  

E-Print Network [OSTI]

studies, the direct chemical bonding of a material to bone has also received attention. Hench, et. al. (1971), introduced a bone-bonding calcia-phosphosilicate glass ceramic and included a theoretical model, based on in-viva studies in rat femurs... bone tissue. In this study, ceramics composed of CaO and A1203 were implanted in young adult rhesus monkeys with favorable results. Greenlee, et. al. (1972), and Greenlee and Beckham (1972) studied bone ingrowth into glass ceramics and reported good...

Trono, Ruben

1975-01-01T23:59:59.000Z

203

E-Print Network 3.0 - animal bone biomechanics Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: animal bone biomechanics Page: << < 1 2 3 4 5 > >> 1 MECHANICAL AND AEROSPACE ENGINEERING COLLOQUIUM SERIES Summary: fluorescent markers of...

204

E-Print Network 3.0 - altered bone material Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

FRAMEWORKS FOR ENGINEERS Session 20.1 m: Musculoskeletal System -Bones Summary: architecture, and equally definite secondary alterations in their external confirmation" VI....

205

E-Print Network 3.0 - allowing normal bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Simulation Environment for Craniofacial Surgical Procedures Dan Morris1 Summary: the completion of the first loop. An additional bone modification tool allows the introduction...

206

E-Print Network 3.0 - affects trabecular bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

at different structural... bone, are ... Source: Gefen, Amit - Department of Biomedical Engineering, Tel Aviv University Collection: Engineering ; Biology and Medicine 2...

207

E-Print Network 3.0 - assess 3d bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Technologies and Information Sciences 2 Combining High-resolution Micro computed Tomography with Material Summary: : Quantification of connectivity in cancellous bone, with...

208

Long-Term Treatment with Eldecalcitol (1?, 25-Dihydroxy-2?- (3-hydroxypropyloxy) Vitamin D3) Suppresses Bone Turnover and Leads to Prevention of Bone Loss and Bone Fragility in Ovariectomized Rats  

Science Journals Connector (OSTI)

The purpose of this study is to estimate the efficacy of eldecalcitol (1?, 25-Dihydroxy-2?- (3-hydroxypropyloxy) vitamin D3; ELD) on bone metabolism after long-term administration. Six-month-old Wistar–Imamichi r...

Satoshi Takeda; Susan Y. Smith; Tatsuya Tamura…

2014-12-01T23:59:59.000Z

209

The Development of a Porcine Model to Evaluate Wound Healing and Infection of Transcutaneous Osseointegrated Weight-Bearing Prostheses  

E-Print Network [OSTI]

focused on the circulation of bone marrow using a channeled titanium implant within the ear chamber of a rabbit [16]. After some time, Branemark was unable to remove the titanium screws from the bone because the interface had become completely fused... porous percutaneous post. Over time, the implant extrudes as the post fills with cell debris. Avulsion refers to a tearing away of the implant from the soft tissue due to externally applied mechanical forces. Infection is the most concerning mode...

Colbert, Kevin

2013-05-31T23:59:59.000Z

210

Identification of potential biophysical and molecular signalling mechanisms underlying hyaluronic acid enhancement of cartilage formation  

Science Journals Connector (OSTI)

...TGF-beta pathway targets activin 6.82 up inhibitor of DNA binding 1 8.57 down inhibitor of DNA binding 2 4.67 up c-Myc transcription...murine bone marrow mesenchymal stem cells in chitosan sponges. Am. J. Vet. Res. 72, 42-50...

2012-01-01T23:59:59.000Z

211

Inhibition of Adhesion, Invasion, and Metastasis by Antibodies Targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen)  

Science Journals Connector (OSTI)

...CEA stimulated Kupffer cells. Clin Exp Metastasis 1998;16:703-12. 51 Van der Velde-Zimmermann D, Verdaasdonk MA, Rademakers LH, De Weger RA, Van den Tweel JG, Joling P. Fibronectin distribution in human bone marrow stroma: matrix assembly and...

Rosalyn D. Blumenthal; Hans J. Hansen; David M. Goldenberg

2005-10-01T23:59:59.000Z

212

Effect of Direct Cell-to-Cell Interaction between the KM-102 Clonal Human Marrow Stromal Cell Line and the HL-60 Myeloid Leukemic Cell Line on the Differentiation and Proliferation of the HL-60 Line  

Science Journals Connector (OSTI)

...1:8 every 5 days using trypsin EDTA dispersant, replaced with fresh medium every 3...activity, 78.0 Ci/mM; New England Nuclear. Boston. MA) in 2-ml aliquots was...and cover slips were dipped in MNR 40 nuclear track emulsion (Konisiroku Photo Ind...

Hiroyuki Ohkawa and Kenichi Harigaya

1987-06-01T23:59:59.000Z

213

Effects of dietary silicon on bone characteristics of poultry  

E-Print Network [OSTI]

of the metal which they contain. Evidence indicates that silicon in the form of sodium meta-silicate (Na Si0 . 9H20) may be tied in with early bone calcification of weanling rats (Carlisle, 1970). The present study was designed to determine if additional..., demonstrated that many of the early workers on the distribution of silicon in the animal body reported values much too high. The amount of silicon reported in biological materials varies greatly; rats have approximately two percent silica in whole blood...

Plyler, James Edward

2012-06-07T23:59:59.000Z

214

Hydroxyapatite-binding peptides for bone growth and inhibition  

DOE Patents [OSTI]

Hydroxyapatite (HA)-binding peptides are selected using combinatorial phage library display. Pseudo-repetitive consensus amino acid sequences possessing periodic hydroxyl side chains in every two or three amino acid sequences are obtained. These sequences resemble the (Gly-Pro-Hyp).sub.x repeat of human type I collagen, a major component of extracellular matrices of natural bone. A consistent presence of basic amino acid residues is also observed. The peptides are synthesized by the solid-phase synthetic method and then used for template-driven HA-mineralization. Microscopy reveal that the peptides template the growth of polycrystalline HA crystals .about.40 nm in size.

Bertozzi, Carolyn R. (Berkeley, CA); Song, Jie (Shrewsbury, MA); Lee, Seung-Wuk (Walnut Creek, CA)

2011-09-20T23:59:59.000Z

215

AUTOMATION IN THE MEAT INDUSTRY | Cutting and Boning  

Science Journals Connector (OSTI)

Abstract The strongest incentives for the industry to adopt automation technology for cutting and boning relate to the drive for improved productivity through reduced labor. Also work environment, increased yield and adaptability to a wide range of customer specifications are important drivers. Automation in the pig meat industry has mainly been adopted in regions with high labor costs such as Northern Europe. In New Zealand the ovine meat industry has been progressive in developing and using automation technology. Automation in the beef industry is limited because of the complexity associated with handling of the size and biological variation of the material.

R. Clarke; J.U. Nielsen; N.T. Madsen

2014-01-01T23:59:59.000Z

216

Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen  

E-Print Network [OSTI]

Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation Adipogenesis Obesity Osteoblastogenesis b-catenin a b s t r a c t Mechanical signals of both low and high mesenchymal stem cell pools from which fat and bone precursors emerge. To identify an idealized mechanical

217

Improved rat genome gene prediction by integration of ESTs with RNA-Seq information  

Science Journals Connector (OSTI)

......from three rat tissues-bone marrow, brain and kidney-with EST data to improve the...data from three rat tissues (kidney, brain and bone marrow) into a gene prediction...experiments Tissues from bone marrow, brain and kidney were harvested from BN or Sprague......

Liping Li; Enguo Chen; Chun Yang; Jun Zhu; Pushkala Jayaraman; Jeffrey De Pons; Catherine C. Kaczorowski; Howard J. Jacob; Andrew S. Greene; Matthew R. Hodges; Allen W. Cowley; Jr; Mingyu Liang; Haiming Xu; Pengyuan Liu; Yan Lu

2015-01-01T23:59:59.000Z

218

Improved rat genome gene prediction by integration of ESTs with RNA-Seq information  

Science Journals Connector (OSTI)

......from three rat tissues-bone marrow, brain and kidney-with EST data to improve the...data from three rat tissues (kidney, brain and bone marrow) into a gene prediction...experiments Tissues from bone marrow, brain and kidney were harvested from BN or Sprague......

Liping Li; Enguo Chen; Chun Yang; Jun Zhu; Pushkala Jayaraman; Jeffrey De Pons; Catherine C. Kaczorowski; Howard J. Jacob; Andrew S. Greene; Matthew R. Hodges; Allen W. Cowley; Jr; Mingyu Liang; Haiming Xu; Pengyuan Liu; Yan Lu

2014-10-01T23:59:59.000Z

219

Impact of Omega-3 Polyunsaturated Fatty Acids on Bone Adaptations to Simulated Resistance Training  

E-Print Network [OSTI]

with arachidonic acid, an n-6 PUFA, for the cyclooxygenase enzyme, modulating prostaglandin E2, a mediator of bone mechanotransduction. Whether this diet affects bone gains during exercise is not well defined. We hypothesized rats consuming a high n-3 PUFA diet...

Camp, Kaleigh Ann

2013-04-30T23:59:59.000Z

220

Bone Surface Reconstruction From CT/MR Images Using Fast Marching and Level Set Methods1)  

E-Print Network [OSTI]

Bone Surface Reconstruction From CT/MR Images Using Fast Marching and Level Set Methods1) Istv surfaces reconstructed from MR volumes are shown. 1 Outline of the project One of our current projects steps of bone surface reconstruction from CT/MR slice images. 2 Main steps of reconstruction 2.1

Chetverikov, Dmitry

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Dermal bone in early tetrapods: a palaeophysiological hypothesis of adaptation for terrestrial acidosis  

Science Journals Connector (OSTI)

...deposits in their endolymphatic lime sacs [39,40], and they...exchange of ions between the bone mineral matrix and the extracellular...no detectable effects on bone mineral content [46]. Thus, it remains...J. Irwin, and D. M. Green 2005 Thermal physiology and...

2012-01-01T23:59:59.000Z

222

Mixed-mode fracture of human cortical bone Elizabeth A. Zimmermann a,b  

E-Print Network [OSTI]

Mixed-mode fracture of human cortical bone Elizabeth A. Zimmermann a,b , Maximilien E. Launey Available online 1 July 2009 Keywords: Human cortical bone Mixed-mode fracture Fracture toughness Fracture mechanisms a b s t r a c t Although the mode I (tensile opening) fracture toughness has been the focus

Ritchie, Robert

223

Journal of Biomechanics 38 (2005) 15171525 Fracture in human cortical bone: local fracture criteria and  

E-Print Network [OSTI]

Journal of Biomechanics 38 (2005) 1517­1525 Fracture in human cortical bone: local fracture, Livermore, CA 94550 Accepted 19 July 2004 Abstract Micromechanical models for fracture initiation such micromechanical models have been developed for the fracture of bone. In fact, although the fracture event

Ritchie, Robert O.

224

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing rats  

E-Print Network [OSTI]

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing-Chomponelle, Theix, 63110 Beaumont, France. Summary. (1) Magnesium deficiency was induced in Sprague-Dawley male rats of deprivation. (3) The leg bones were fragmented as shown in figure 1. Their magnesium content had decreased

Paris-Sud XI, Université de

225

Biomimetic hydroxyapatite-containing composite nanofibrous substrates for bone tissue engineering  

Science Journals Connector (OSTI)

...concentration of calcium ions required to stimulate...osteoblasts for bone tissue engineering (figure-1 b). These...which favoured Ca2+ ion chelation. The alternative...concentrations of Ca and P ions up to a ratio of 1...proliferation for bone tissue engineering. 5. Conclusions This...

2010-01-01T23:59:59.000Z

226

Level of osteopenia and bone recovery in alcohol-fed adolescent rats  

E-Print Network [OSTI]

consumption on young, actively growing adolescent bones have not been done. The objective of this study was to determine the level of bone recovery, if any, once an adolescent ceases alcohol consumption. Fifty, 4-week old, female, Sprague-Dawley rats were...

Spears, Heather Lynae

2012-06-07T23:59:59.000Z

227

The bending and dynamic mechanical properties of cortical bone: the effects of sodium fluoride and the relationship to physical properties  

E-Print Network [OSTI]

Bone is a complex organic composite material. The graphics. interface between the mineral and organic phases of bone is significant both to medicine and to the biokinetics, a field which seeks to create advanced synthetic materials by copying...

McCurdy-Rahn, Megan Calista

1998-01-01T23:59:59.000Z

228

Quantitative analysis of radiological changes in alveolar bone around connected osseo-integrated dental implants and natural abutment teeth  

Science Journals Connector (OSTI)

To evaluate quantitatively the long-term changes in alveolar bone around toothimplant connections using a digital subtraction technique.

Akihiro Takashima DDS; Dr. Kazunori Yoshiura DDS; PhD; Kenji Tokumori…

2003-06-01T23:59:59.000Z

229

Single x-ray transmission system for bone mineral density determination  

SciTech Connect (OSTI)

Bones are the support of the body. They are composed of many inorganic compounds and other organic materials that all together can be used to determine the mineral density of the bones. The bone mineral density is a measure index that is widely used as an indicator of the health of the bone. A typical manner to evaluate the quality of the bone is a densitometry study; a dual x-ray absorptiometry system based study that has been widely used to assess the mineral density of some animals' bones. However, despite the success stories of utilizing these systems in many different applications, it is a very expensive method that requires frequent calibration processes to work properly. Moreover, its usage in small species applications (e.g., rodents) has not been quite demonstrated yet. Following this argument, it is suggested that there is a need for an instrument that would perform such a task in a more reliable and economical manner. Therefore, in this paper we explore the possibility to develop a new, affordable, and reliable single x-ray absorptiometry system. The method consists of utilizing a single x-ray source, an x-ray image sensor, and a computer platform that all together, as a whole, will allow us to calculate the mineral density of the bone. Utilizing an x-ray transmission theory modified through a version of the Lambert-Beer law equation, a law that expresses the relationship among the energy absorbed, the thickness, and the absorption coefficient of the sample at the x-rays wavelength to calculate the mineral density of the bone can be advantageous. Having determined the parameter equation that defines the ratio of the pixels in radiographies and the bone mineral density [measured in mass per unit of area (g/cm{sup 2})], we demonstrated the utility of our novel methodology by calculating the mineral density of Wistar rats' femur bones.

Jimenez-Mendoza, Daniel; Vargas-Vazquez, Damian [Division de Investigacion y Posgrado, Facultad de Ingenieria, Universidad Autonoma de Queretaro, Cerro de las Campanas s/n., C.P. 76010, Queretaro, Qro. (Mexico); Espinosa-Arbelaez, Diego G. [Posgrado en Ciencia e Ingenieria en Materiales, Instituto de Investigaciones en Materiales, Universidad Nacional Autonoma de Mexico, Av. Universidad 3000, C.P. 04510, Coyoacan, Mexico D.F. (Mexico); Departamento de Nanotecnologia, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico); Giraldo-Betancur, Astrid L. [Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Libramiento Norponiente 2000, C.P. 76230, Fracc. Real de Juriquilla, Qro. (Mexico); Hernandez-Urbiola, Margarita I. [Posgrado en Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico); Departamento de Nanotecnologia, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico); Rodriguez-Garcia, Mario E. [Departamento de Nanotecnologia, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico)

2011-12-15T23:59:59.000Z

230

Hierarchical interconnections in the nano-composite material Bone: Fibrillar Cross-Links resist fracture on several length scales  

E-Print Network [OSTI]

Hierarchical interconnections in the nano-composite material Bone: Fibrillar Cross-Links resist bone samples, possibly resisting the propagation of these cracks. Bone is one of the most important collagen and hydroxyapatite. Such materials are based on the crystal-polymer interactions on the molecular

Fygenson, Deborah Kuchnir

231

Mesenchymal Stem Cell Transplantation to Promote Bone Healing Chan Gao,1,2  

E-Print Network [OSTI]

in humans. The objective of the current study was to deter- mine if transplantation of mesenchymal stromal performed on reasonably young, active recipients in the past two decades have used implants with porous individuals as a result of treatment for cancer or graft versus host disease.5 The majority of joint

Buschmann, Michael

232

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: Potential model for thymic education  

SciTech Connect (OSTI)

Characteristic lesions in mice hemi- or homozygous for the X-linked mutation scurfy (sf) include lymphohistiocytic proliferation in the skin and lymphoid organs, Coombs' test-positive anemia, hypergammaglobulinemia, and death by 24 days of age. The role of the thymus in the development of fatal lymphoreticular disease in the scurfy mouse was investigated. Neonatal thymectomy doubles the life span of scurfy mice, moderates the histologic lesions, and prevents anemia, despite the continued presence of high levels of serum IgG. Animals bred to be nude and scurfy (nu/nu;sf/Y) are viable, fertile, and free of scurfy lesions. Bone marrow from scurfy mice can reconstitute lethally irradiated, H-2-compatible animals but does not transmit scurfy disease. The authors conclude, from these data, that scurfy lesions are mediated by T lymphocytes that mature in an abnormal (sf) thymic environment.

Godfrey, V.L.; Rinchik, E.M.; Russell, L.B. (Oak Ridge National Lab., Oak Ridge, TN (United States)); Wilkinson, J.E. (Univ. of Tennessee, Knoxville (United States))

1991-07-01T23:59:59.000Z

233

Geek-Up[6.10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's  

Broader source: Energy.gov (indexed) [DOE]

10.2011]: Thermoelectrics' Great Power, Key Ingredient in 10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's Nanostructure Geek-Up[6.10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's Nanostructure June 10, 2011 - 5:07pm Addthis Data image on lead telluride thermal conductivity | Photo Courtesy of Oak Ridge National Laboratory Data image on lead telluride thermal conductivity | Photo Courtesy of Oak Ridge National Laboratory Niketa Kumar Niketa Kumar Public Affairs Specialist, Office of Public Affairs What does this mean for me? Identifying a key ingredient in bone's nanostructure may help treat and prevent bone diseases such as osteoporosis and develop new light-weight, high-strength materials for innovative technologies. Advanced thermoelectric materials could be used to develop vehicle

234

Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions  

DOE Patents [OSTI]

The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients.

Srivastava, Suresh C. (Setauket, NY); Meinken, George E. (Middle Island, NY); Mausner, Leonard F. (Stony Brook, NY); Atkins, Harold L. (Setauket, NY)

1998-12-29T23:59:59.000Z

235

Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions  

DOE Patents [OSTI]

The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients. 5 figs.

Srivastava, S.C.; Meinken, G.E.; Mausner, L.F.; Atkins, H.L.

1998-12-29T23:59:59.000Z

236

Bone Penetration of Amoxicillin and Clavulanic Acid Evaluated by Population Pharmacokinetics and Monte Carlo Simulation  

Science Journals Connector (OSTI)

...infusion. Simulations with our...equilibration by modeling and to derive...Monte Carlo simulations. Drusano...bone was rapid for both...using a fully automated extraction...pharmacokinetic modeling and Monte Carlo simulation. Antimicrob...

Cornelia B. Landersdorfer; Martina Kinzig; Jürgen B. Bulitta; Friedrich F. Hennig; Ulrike Holzgrabe; Fritz Sörgel; Johannes Gusinde

2009-03-23T23:59:59.000Z

237

E-Print Network 3.0 - arthritic bone loss Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Knee Arthroplasty in a Series of 48 Patients Summary: with the loss of thickness of polyethylene tibial bearings after knee arthroplasty. J Bone Joint Surg Am. 2007... -4 Optimal...

238

E-Print Network 3.0 - alveolar bone formation Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sutures to Deciduous Dentition in Nonhuman Primates K... .D., E.R. Dumont, Ph.D., T.D. Smith, Ph.D. Objective: The relationship of the human premaxillary bone Source: Dumont,...

239

Clinical diagnostic indicators of renal and bone damage in rats intramuscularly injected with depleted uranium  

Science Journals Connector (OSTI)

......intramuscularly injected with depleted uranium S. Fukuda 1 M. Ikeda 1 M...related to kidney and bone in depleted uranium (DU)-injected rats were...injected is low. INTRODUCTION Depleted uranium (DU) accumulates like natural......

S. Fukuda; M. Ikeda; M. Chiba; K. Kaneko

2006-06-01T23:59:59.000Z

240

8 - Bioactive glass and glass–ceramic foam scaffolds for bone tissue restoration  

Science Journals Connector (OSTI)

Abstract: One of the major goals of bone tissue engineering is the development of appropriate porous biomaterials (scaffolds) that can stimulate the body’s own regenerative mechanism, to induce tissue healing and self-repair. Bioactive glasses are excellent candidates for producing 3-D scaffolds, as their properties can be finely tailored depending on the glass composition, and they can bond to bone, inducing osteogenesis at the defect site. This chapter is focused on glass/glass–ceramic scaffolds characterized by foam-like architecture closely mimicking that of natural cancellous bone. After giving an overview of the features and limitations of the biomedical glass foams investigated in the literature, future directions of research will be described, emphasizing the challenge to develop multifunctional foams able to combine bone regeneration with special therapeutic functionalities.

F. Baino; C. Vitale-Brovarone

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

The petrous portion of the human temporal bone: potential for forensic individuation  

E-Print Network [OSTI]

are threefold: (1) To investigate variability in the shape of the petrous portion of the human temporal bone using two-dimensional morphometric analysis; (2) to evaluate the reliability of the resultant method in forensic identification; and (3) to consider...

Wiersema, Jason Matthew

2009-06-02T23:59:59.000Z

242

Microstructured Hydrogen Fuel Cells  

Science Journals Connector (OSTI)

Micro fuel cells ; Polymer electrolyte membrane fuel cells ; Proton exchange membrane fuel cells ...

Luc G. Frechette

2014-05-01T23:59:59.000Z

243

The Effects of Multiple Unloading Exposures on Bone Properties in the Femur of Adult Male Rats  

E-Print Network [OSTI]

to the National Osteoporosis Foundation, approximately 10 million people have the condition, with another 34 million currently at risk. It is estimated that half of all women over 50 and a quarter of all men will break a bone due to osteoporosis (10). Fractures....? During long term missions, such as to Mars, the astronauts may encounter situations where they could experience high impact forces relative to those experienced in transit. This, coupled with a potential reduction in bone strength due to microgravity...

Morgan, Derrick Scott

2012-07-16T23:59:59.000Z

244

Patterns of Practice in Palliative Radiotherapy for Painful Bone Metastases: A Survey in Japan  

SciTech Connect (OSTI)

Purpose: To determine the current patterns of practice in Japan and to investigate factors that may make clinicians reluctant to use single-fraction radiotherapy (SF-RT). Methods and Materials: Members of the Japanese Radiation Oncology Study Group (JROSG) completed an Internet-based survey and described the radiotherapy dose fractionation they would recommend for four hypothetical cases describing patients with painful bone metastasis (BM). Case 1 described a patient with an uncomplicated painful BM in a non-weight-bearing site from non-small-cell lung cancer. Case 2 investigated whether management for a case of uncomplicated spinal BM would be different from that in Case 1. Case 3 was identical with Case 2 except for the presence of neuropathic pain. Case 4 investigated the prescription for an uncomplicated painful BM secondary to oligometastatic breast cancer. Radiation oncologists who recommended multifraction radiotherapy (MF-RT) for Case 2 were asked to explain why they considered MF-RT superior to SF-RT. Results: A total of 52 radiation oncologists from 50 institutions (36% of JROSG institutions) responded. In all four cases, the most commonly prescribed regimen was 30 Gy in 10 fractions. SF-RT was recommended by 13% of respondents for Case 1, 6% for Case 2, 0% for Case 3, and 2% for Case 4. For Case 4, 29% of respondents prescribed a high-dose MF-RT regimen (e.g., 50 Gy in 25 fractions). The following factors were most often cited as reasons for preferring MF-RT: 'time until first increase in pain' (85%), 'incidence of spinal cord compression' (50%), and 'incidence of pathologic fractures' (29%). Conclusions: Japanese radiation oncologists prefer a schedule of 30 Gy in 10 fractions and are less likely to recommend SF-RT. Most Japanese radiation oncologists regard MF-RT as superior to SF-RT, based primarily on the time until first increase in pain.

Nakamura, Naoki, E-mail: naokinak@luke.or.jp [Department of Radiation Oncology, St. Luke's International Hospital, Tokyo (Japan); Shikama, Naoto [Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka (Japan); Wada, Hitoshi [Department of Radiation Oncology, Miyagi Cancer Center, Natori (Japan); Harada, Hideyuki [Division of Radiation Oncology, Shizuoka Cancer Center, Mishima (Japan); Nozaki, Miwako [Department of Radiology, Dokkyo Medical University Koshigaya Hospital, Koshigaya (Japan); Nagakura, Hisayasu [Department of Radiology, KKR Sapporo Medical Center, Sapporo (Japan); Tago, Masao [Department of Radiology, Teikyo University Mizonokuchi Hospital, Kawasaki (Japan); Oguchi, Masahiko [Department of Radiation Oncology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo (Japan); Uchida, Nobue [Department of Radiation Oncology, Shimane University Hospital, Izumo (Japan)

2012-05-01T23:59:59.000Z

245

Dickkopf-1 in Craniofacial Bone and Tooth Development  

E-Print Network [OSTI]

result in osteopenia. Targeted expression of Dkk1 in dental epithelial cells leads to the formation of dysfunctional enamel knots and subsequent tooth defects during embryonic development. However, the direct role of Dkk1 in post-natal dentinogenesis...

Rodgers, Anika Sarah

2014-08-20T23:59:59.000Z

246

Effect of dietary calcium and phosphorus levels on performance and bone development of large-framed developing boars  

E-Print Network [OSTI]

quantitative carcass measurement among boars fed the six treatment diets. Bone breaking load (BKL) of the femurs increased quadratically (P&. 01) as mineral levels increased with a predicted maximum response at 1. 21X calcium and 1. 01X phosphorus. Breaking..., feed intake and feed efficiency for developing boars. However, higher dietary phosphorus levels were needed for maximum bone develop- ment. Maximum response was obtained from the following phosphorus levels: bone breaking load ranged from 1. 01X...

Robinson, Robert Glen

1975-01-01T23:59:59.000Z

247

Biochemical Markers of Bone Turnover in Percutaneous Vertebroplasty for Osteoporotic Compression Fracture  

SciTech Connect (OSTI)

Purpose. To evaluate relationships between biochemical markers of bone turnover, bone mineral density, and new compression fractures following vertebroplasty. Methods. Initially, we enrolled 30 consecutive patients with vertebral compression fractures caused by osteoporosis. Twenty-three of the 30 patients visited our hospital for follow-up examinations for more than 4 weeks after vertebroplasty. The patients were divided into two groups: patients with new fractures (group F) and patients with no new fractures (group N). We analyzed differences in the following parameters between these two groups: serum bone alkaline phosphatase, urinary crosslinked N-telopeptide of type I collagen, urinary deoxypyridinoline, and bone mineral density. Next, the patients were divided into another two groups: patients with higher risk (group H: urinary crosslinked N-telopeptide of type I collagen >54.3 nmol BCE/mmol Cr or urinary deoxypyridinoline >7.6 nmol/mmol Cr, and serum bone alkaline phosphatase <29.0 U/l) and patients with lower risk (group L). We analyzed the difference in the rate of new fractures between these two groups. Results. We identified 9 new fractures in 7 patients. There were no significant differences between groups F and N. We identified 5 new fractures in 3 of the 4 patients in group H, and 4 new fractures in 4 of the 19 patients in group L. There was a significant difference in the rate of new fractures between groups H and L. Conclusions. A combination of high levels of bone resorption markers and normal levels of bone formation markers may be associated with increased risk of new recurrent fractures after percutaneous vertebroplasty.

Komemushi, Atsushi, E-mail: kome64@yo.rim.or.jp; Tanigawa, Noboru; Kariya, Shuji; Kojima, Hiroyuki; Shomura, Yuzo; Tokuda, Takanori; Nomura, Motoo; Terada, Jiro; Kamata, Minoru; Sawada, Satoshi [Kansai Medical University, Department of Radiology (Japan)

2008-03-15T23:59:59.000Z

248

Electron Microscopy and Analytical X-ray Characterization of Compositional and Nanoscale Structural Changes in Fossil Bone  

E-Print Network [OSTI]

on the identification of surviving collagen in bulk bonebulk regions of bone. This fact might prove exceptionally true if the identification

Boatman, Elizabeth

2012-01-01T23:59:59.000Z

249

Automated 3D trabecular bone structure analysis of the proximal femur—prediction of biomechanical strength by CT and DXA  

E-Print Network [OSTI]

z ORIGINAL ARTICLE Automated 3D trabecular bone structureIntroduction An automated 3D segmentation algorithm wasstudy was to use an automated 3D segmentation algorithm to

2010-01-01T23:59:59.000Z

250

Fuel Cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuel Cells Fuel Cells Converting chemical energy of hydrogenated fuels into electricity Project Description Invented in 1839, fuels cells powered the Gemini and Apollo space missions, as well as the space shuttle. Although fuel cells have been successfully used in such applications, they have proven difficult to make more cost-effective and durable for commercial applications, particularly for the rigors of daily transportation. Since the 1970s, scientists at Los Alamos have managed to make various scientific breakthroughs that have contributed to the development of modern fuel cell systems. Specific efforts include the following: * Finding alternative and more cost-effective catalysts than platinum. * Enhancing the durability of fuel cells by developing advanced materials and

251

Fuel Cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuel Cells Fuel Cells The Solid State Energy Conversion Alliance (SECA) program is responsible for coordinating Federal efforts to facilitate development of a commercially relevant and robust solid oxide fuel cell (SOFC) system. Specific objectives include achieving an efficiency of greater than 60 percent, meeting a stack cost target of $175 per kW, and demonstrating lifetime performance degradation of less than 0.2 percent per

252

Fuel Cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuel Cells The Solid State Energy Conversion Alliance (SECA) program is responsible for coordinating Federal efforts to facilitate development of a commercially relevant and robust...

253

Fuel Cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Materials Science » Materials Science » Fuel Cells Fuel Cells Research into alternative forms of energy, especially energy security, is one of the major national security imperatives of this century. Get Expertise Melissa Fox Applied Energy Email Catherine Padro Sensors & Electrochemical Devices Email Fernando Garzon Sensors & Electrochemical Devices Email Piotr Zelenay Sensors & Electrochemical Devices Email Rod Borup Sensors & Electrochemical Devices Email Karen E. Kippen Experimental Physical Sciences Email Like a battery, a fuel cell consists of two electrodes separated by an electrolyte-in polymer electrolyte fuel cells, the separator is made of a thin polymeric membrane. Unlike a battery, a fuel cell does not need recharging-it continues to produce electricity as long as fuel flows

254

Transient temperature rise due to ultrasound absorption at a bone/soft-tissue interface  

Science Journals Connector (OSTI)

Thermal effects due to high ultrasound absorption in bone pose an ongoing safety issue. Of considerable concern is the heating of the soft tissue adjacent to the bone surface. Mathematical models can be useful in predicting the transient temperature near the interface during insonation. This paper develops a model that provides the temperature field in terms of simple expressions that convey the functional dependence of the material properties and are easily incorporated into standards and ultrasound machine software yet are able to incorporate the material properties of both bone and soft tissue. The model contains an asymptotic theory based upon a “high-attenuation” assumption: the distance diffused by heat over the time of interest is large compared to the ultrasound attenuation length. Model predictions of temperature rise and location of maximum temperature were in close agreement with finite-element calculations using parameters appropriate for radiation-force imaging and focused-ultrasound surgery.

Matthew R. Myers

2004-01-01T23:59:59.000Z

255

Abstract 2154: Bone metastasis targeting: a novel approach to reach bone using zoledronate anchored nanoparticles loaded with docetaxel.  

Science Journals Connector (OSTI)

...periment on contact transmission were presented earlier...relative to contact transmission will be included here...passage, successful transmission was obtained with cell-free...the intraperitoneal route at 1 "8 days of age...came from an inbred line of S.C. White Leghorns...

Vinoth Kumar Megraj Khandelwal; Kiran R. Chaudhari; Abhinesh Kumar; Anil K. Mishra; Jukka Monkkonen; and Rayasa S. Ramachandra Murthy

2013-04-15T23:59:59.000Z

256

Additively manufactured 3D porous Ti-6Al-4V constructs mimic trabecular bone structure and regulate osteoblast proliferation, differentiation and local factor production in a porosity and surface roughness dependent manner  

Science Journals Connector (OSTI)

Additive manufacturing by laser sintering is able to produce high resolution metal constructs for orthopedic and dental implants. In this study, we used a human trabecular bone template to design and manufacture Ti-6Al-4V constructs with varying porosity via laser sintering. Characterization of constructs revealed interconnected porosities ranging from 15–70% with compressive moduli of 2579–3693 MPa. These constructs with macro porosity were further surface-treated to create a desirable multi-scale micro-/nano-roughness, which has been shown to enhance the osseointegration process. Osteoblasts (MG63 cells) exhibited high viability when grown on the constructs. Proliferation (DNA) and alkaline phosphatase specific activity, an early differentiation marker, decreased as porosity increased, while osteocalcin, a late differentiation marker, as well as osteoprotegerin, vascular endothelial growth factor and bone morphogenetic proteins 2 and 4 increased with increasing porosity. Three-dimensional (3D) constructs with the highest porosity and surface modification supported the greatest osteoblast differentiation and local factor production. These results indicate that additively manufactured 3D porous constructs mimicking human trabecular bone and produced with additional surface treatment can be customized for increased osteoblast response. Increased factors for osteoblast maturation and differentiation on high porosity constructs suggest the enhanced performance of these surfaces for increasing osseointegration in vivo.

Alice Cheng; Aiza Humayun; David J Cohen; Barbara D Boyan; Zvi Schwartz

2014-01-01T23:59:59.000Z

257

A parametric analysis of bone fixation plates on fractured equine third metacarpal  

E-Print Network [OSTI]

A P~TRIC ANALYSIS OI' BONE FIXATION PLATES ON FRACTURED EQUINE THIRD lKTACARPAL A Thesis by Donald Reagan Ray Submitted to tnk Graduate College of Texas A&N University in partial fulfillment of the requirement for the degree of MASTER... OF SCIENCE Hay 1970 Major Subject: Civil Engineering A PARAMETRIC ANALYSIS OF BONE FIXATION PLATES ON FRACTURED EQUINE THIRD METACARPAL A Thesis Donald Reagan Ray Approved as to style and content by: (Cha of Committee) / I (Head of D artment...

Ray, Donald Reagan

2012-06-07T23:59:59.000Z

258

Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats  

E-Print Network [OSTI]

but not the tissue material properties in aged rats Mohammad Shahnazari a , Wei Yao a , WeiWei Dai a , Bob Wang in aged osteopenic rats to explain how bone material and bone mass may be affected by the dose of bisphosphonates (BP) and contribute to their anti- fracture efficacy. Eighteen-month old female rats underwent

Ritchie, Robert

259

On Smoothing Surfaces in Voxel Based Finite Element Analysis of Trabecular Bone  

E-Print Network [OSTI]

-)finite element analysis based on three-dimen- sional computed tomography (CT) data of human bone takes place finite element (FE) analysis. The approach based on the FE analysis leads to linear systems of equations analysis the computational domain is composed of a multitude of tiny cubes, so-called voxels

Frey, Pascal

260

School of Architecture, Design and the Built Environment Project Title: Artificial bone for prosthetic hip joints  

E-Print Network [OSTI]

formation by the Additive Manufacturing (AM) direct printing process. The artificial bone must and the development of new additive manufacturing techniques for medical devices. The group has active links and structural gradients into the prosthesis. It is envisioned this could involve the use of additively

Evans, Paul

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Methods for identifying cancellous bone specimen location and size for the Reduced Platen Compression Test  

E-Print Network [OSTI]

method for defining the specimen thickness is to average the largest and smallest overall bone lengths in the test group and use a reference thickness of 2 millimeters as a percentage of this average length. This percentage of the overall average length...

Cowen, Kyle Ray

2013-02-22T23:59:59.000Z

262

USE OF CdTe DETECTORS IN BONE MINERAL MEASUREMENTS J. VOGEL, J. ULLMAN  

E-Print Network [OSTI]

375 USE OF CdTe DETECTORS IN BONE MINERAL MEASUREMENTS J. VOGEL, J. ULLMAN Nuclear Medicine. Cet ensemble emploie des détecteurs CdTe mesurant la transmission d'un faisceau collimaté de rayons X periods of prolonged bedrest or weightlessness. The unit employs CdTe detectors to mea- sure

Paris-Sud XI, Université de

263

Characterization of Bone Metastases from Rapid Autopsies of Prostate Cancer Patients  

Science Journals Connector (OSTI)

...as tumor tissues are lodged in the calcified, dense bone infrastructure. Investigation of metastatic prostate cancer at the phenotypic...FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.Blood 1998;92:3025-34. 19. Pampalakis...

Rohit Mehra; Chandan Kumar-Sinha; Sunita Shankar; Robert J. Lonigro; Xiaojun Jing; Neena E. Philips; Javed Siddiqui; Bo Han; Xuhong Cao; David C. Smith; Rajal B. Shah; Arul M. Chinnaiyan; and Kenneth J. Pienta

2011-06-15T23:59:59.000Z

264

Radiocarbon Dating of Petroleum-Impregnated Bone from Tar Pits at Rancho La Brea, California  

Science Journals Connector (OSTI)

...Angeles County Museum for Natural History. These bones are...deviation (9). Analysis by gas chromatography of hexane...miles (48 km) south of Corpus Christi, Texas. The core from...yields a sample suitable for gas-chro-matographic analysis...

T. Y. Ho; Leslie F. Marcus; Rainer Berger

1969-05-30T23:59:59.000Z

265

Nano-mechanical properties of individual mineralized collagen fibrils from bone tissue  

Science Journals Connector (OSTI)

...research-article Research articles 1004 25 27 131 Nano-mechanical properties of individual mineralized...phenomenological model is used to describe the fibril nano-mechanical behaviour. biomechanics...materials. Bone is structurally a composite as nano-fibres of CFs act as a template for the...

2011-01-01T23:59:59.000Z

266

Stability and Three-Dimensional Analysis of Bone Formation in Longitudinally Fluted Miniscrew Implants  

E-Print Network [OSTI]

The purpose of the present study is to evaluate the effects of longitudinal flutes on mini-screw implant (MSI) bone healing and stability. Using 11 skeletally mature New Zealand White rabbits, 33 longitudinally fluted and 33 non-fluted MSIs were...

Truong, An Van

2014-04-22T23:59:59.000Z

267

Hear-Through and Mic-Through Augmented Reality: Using Bone Conduction to Display Spatialized Audio  

E-Print Network [OSTI]

Hear-Through and Mic-Through Augmented Reality: Using Bone Conduction to Display Spatialized Audio-generated audio for augmented reality (AR) applications. Analogous to optical-see-through and video-see-through techniques in the visual domain, we present Hear-Through and Mic-Through audio AR. Hear-Through AR uses

Lindeman, Robert W.

268

Electrochemical cell  

DOE Patents [OSTI]

An improved secondary electrochemical cell is disclosed having a negative electrode of lithium aluminum, a positive electrode of iron sulfide, a molten electrolyte of lithium chloride and potassium chloride, and the combination that the fully charged theoretical capacity of the negative electrode is in the range of 0.5-1.0 that of the positive electrode. The cell thus is negative electrode limiting during discharge cycling. Preferably, the negative electrode contains therein, in the approximate range of 1-10 volume % of the electrode, an additive from the materials of graphitized carbon, aluminum-iron alloy, and/or magnesium oxide.

Kaun, Thomas D. (New Lenox, IL)

1984-01-01T23:59:59.000Z

269

A Novel Method for the Evaluation of Mechanical Properties of Cancellous Bone in the Rat Distal Femur  

E-Print Network [OSTI]

of the bone remaining intact; these studies will be reviewed in the following sections. 2.3.1 Femoral Neck Testing One testing method that interrogates a region of bone containing both cortical and cancellous bone is the femoral neck test. This method... limitation of this method is that while it is closer to simulating uni-axial compression than the indentation method, there remains tri-axial stress caused by the intact cortical shell. Figure 6: RPC Specimen Selection and Testing Method(14) 10...

Lucas, Matthew W.

2010-01-14T23:59:59.000Z

270

Photovoltaic cell  

DOE Patents [OSTI]

In a photovoltaic cell structure containing a visibly transparent, electrically conductive first layer of metal oxide, and a light-absorbing semiconductive photovoltaic second layer, the improvement comprising a thin layer of transition metal nitride, carbide or boride interposed between said first and second layers.

Gordon, Roy G. (Cambridge, MA); Kurtz, Sarah (Somerville, MA)

1984-11-27T23:59:59.000Z

271

Potential commercial application of a bi-layer bone-ligament regeneration scaffold to anterior cruciate ligament replacement  

E-Print Network [OSTI]

A business model was created in order to explore the commercial application of a bi-layer bone-ligament scaffold to the treatment of torn anterior cruciate ligaments (ACL) requiring replacement. The two main keys in producing ...

Li, Jessica C. (Jessica Ching-Yi)

2006-01-01T23:59:59.000Z

272

Evaluation of the Effects of Green Tea Extracts on Bone Homeostasis in the Ts65Dn Down Syndrome Mouse Model  

E-Print Network [OSTI]

Evaluation of the Effects of Green Tea Extracts on Bone Homeostasis in the Ts65Dn Down Syndrome- gallate (EGCG), an aromatic polyphenol found in high concentrations in green tea, is a known inhibitor

Zhou, Yaoqi

273

Regional geologic characterization of the Second Bone Spring Sandstone, Delaware basin, Lea and Eddy Counties, New Mexico  

E-Print Network [OSTI]

The Bone Spring Formation is a series of interbedded siliciclastics and carbonates that were deposited in the Delaware basin during the Leonardian (Early Permian). It consists of the First, Second and Third Carbonate and the First, Second and Third...

Downing, Amanda Beth

2012-06-07T23:59:59.000Z

274

Accuracy and precision of lumbar bone mineral content by dual-energy X-ray absorptiometry in live female monkeys  

Science Journals Connector (OSTI)

Dual-energy X-ray absorptiometry (DXA) was used...in vivo bone mineral content (BMC) of lumbar vertebrae in 20...Macaca fascicularis). The ash weight of the third lumbar vertebra (L3) was compared to the measured...

M. J. Jayo; S. E. Rankin; D. S. Weaver; C. S. Carlson…

1991-01-01T23:59:59.000Z

275

3D printing as an efficient way for comparative study of biomimetic structures — trabecular bone and honeycomb  

Science Journals Connector (OSTI)

The mechanical properties of engineered trabecular bone and honeycomb structures are investigated by the combined use of the 3D printing technology and the compression test. The engineered ... those by the previo...

Yong-Jin Yoon; Seung Ki Moon; Jihong Hwang

2014-11-01T23:59:59.000Z

276

Nanocrystal Solar Cells  

E-Print Network [OSTI]

research on organic photovoltaic cells since small molecule10 years prior (4). Photovoltaic cells with an active layerof the associated photovoltaic cells. 2.4 Charge transport

Gur, Ilan

2006-01-01T23:59:59.000Z

277

E-Print Network 3.0 - alveolar macrophages isolated Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Jessica Guzmn-Morales a,b , Marianne B... January 2011 Available online xxxx Keywords: Chitosan Bone marrow-derived macrophages ... Source: Buschmann, Michael - Biomaterials and...

278

E-Print Network 3.0 - avb3-integrin inside-out signaling Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Southwestern Medical Center at Dallas Collection: Biology and Medicine 42 Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived...

279

Final Report for completed IPP Project:"Development of Plasma Ablation for Soft Tissue and Bone Surgery"  

SciTech Connect (OSTI)

ArthroCare is a medical device company that develops, manufactures, and markets an advanced surgical tool, a plasma electro-surgical system for cutting and removing tissue. The hand-held electrical discharge device produces plasma in a biocompatible conductive fluid and tissue to which it is applied during surgery. Its products allow surgeons to operate with increased precision and accuracy, limiting damage to surrounding tissue thereby reducing pain and speeding recovery for the patient. In the past, the design of ArthfoCare's plasma wands has been an empirical undertaking. One goal of this R&D program was to put the phenomena involved on a sound scientific footing, allowing optimization of existing plasma based electro-surgery system technology, and the design and manufacture of new and improved kinds of scalpels, in particular for the surgical cutting of bone. Another important related goal of the program was to develop, through an experimental approach, new plasma wand approaches to the cutting ('shaving') of hard bone tissue. The goals of the CRADA were accomplished - computer models were used to predict important parameters of the plasma discharge and the bone environment, and several different approaches to bone-shaving were developed and demonstrated. The primary goal of the project was to develop and demonstrate an atmospheric-pressure plasma tool that is suitable for surgical use for shaving bone in humans. This goal was accomplished, in fact with several different alternative plasma approaches. High bone ablation speeds were measured. The use of probes ('plasma wand' - the surgical tool) with moving active electrodes was also explored, and there are advantages to this method. Another important feature is that the newly-exposed bone surface have only a very thin necrosis layer; this feature was demonstrated. This CRADA has greatly advanced our understanding of bone removal by atmospheric pressure plasmas in liquid, and puts ArthroCare in a good position to develop the techniques for commercial (surgical) application.

Brown, Ian

2009-09-01T23:59:59.000Z

280

Stationary Fuel Cells: Overview of Hydrogen and Fuel Cell Activities...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Stationary Fuel Cells: Overview of Hydrogen and Fuel Cell Activities Stationary Fuel Cells: Overview of Hydrogen and Fuel Cell Activities Presentation covers stationary fuel cells...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Fuel Cell Technologies Overview: 2011 Fuel Cell Seminar | Department...  

Broader source: Energy.gov (indexed) [DOE]

Fuel Cell Technologies Overview: 2011 Fuel Cell Seminar Fuel Cell Technologies Overview: 2011 Fuel Cell Seminar Presentation by Sunita Satyapal at the Fuel Cell Seminar on November...

282

Fuel Cell Technologies Overview: 2011 Fuel Cell Seminar | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Overview: 2011 Fuel Cell Seminar Fuel Cell Technologies Overview: 2011 Fuel Cell Seminar Presentation by Sunita Satyapal at the Fuel Cell Seminar on November 1, 2011. Fuel Cell...

283

Automatic detection of bone fragments in poultry using multi-energy x-rays  

DOE Patents [OSTI]

At least two linear arrays of x-ray detectors are placed below a conveyor belt in a poultry processing plant. Multiple-energy x-ray sources illuminate the poultry and are detected by the detectors. Laser profilometry is used to measure the poultry thickness as the x-ray data is acquired. The detector readout is processed in real time to detect the presence of small highly attenuating fragments in the poultry, i.e., bone, metal, and cartilage.

Gleason, Shaun S. (Knoxville, TN); Paulus, Michael J. (Knoxville, TN); Mullens, James A. (Knoxville, TN)

2002-04-09T23:59:59.000Z

284

Proposed BackBone API Preliminary Draft v1.0  

E-Print Network [OSTI]

Smart Trek Proposed BackBone API Preliminary Draft v1.0 Table of Contents 1.0) API diagram / Introduction 2.0) Requirements 3.0) Class skeletons 4.0) Isp Examples 4.1) Domain Inbound API example 4.2) SDD Inbound API example 4.3) SDD Outbound API example 4.4) ItsFrame Inbound API example 4.5) ItsFrame Outbound

285

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2  

Science Journals Connector (OSTI)

... a miR-34a precursor (pre-miR-34a) but enhanced by an antisense miR-34a inhibitor (anti-miR-34a), indicating that miR-34a regulation of bone resorption in mice ... -34a mimic can attenuate postmenopausal osteoporosis using an ovariectomy (OVX) mouse model and a chitosan (CH) nanoparticle vehicle. Reduction of uterine weight in all ovariectomized mice indicated effective ...

Jing Y. Krzeszinski; Wei Wei; HoangDinh Huynh; Zixue Jin; Xunde Wang; Tsung-Cheng Chang; Xian-Jin Xie; Lin He; Lingegowda S. Mangala; Gabriel Lopez-Berestein; Anil K. Sood; Joshua T. Mendell; Yihong Wan

2014-06-25T23:59:59.000Z

286

Growth and bone development in weanling quarter horses fed diets supplemented with sodium zeolite-A  

E-Print Network [OSTI]

GROWTH AND BONE DEVELOPMENT IN WEANLING QUARTER HORSES FED DIETS SUPPLEMENTED WITH SODIUM ZEOLITE-A A Thesis by KIMBERLY SUZANNE FREY Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... in Weanling Quarter Horses Fed Diets Supplemented with Sodium Zeolite-A. (December 1991) Kimberly Suzanne Frey, B. S. , Texas A&M University Chair of Advisory Committee: Dr. Gary D. Potter Sixty Quarter Horse weanlings were used in a study to determine...

Frey, Kimberly Suzanne

2012-06-07T23:59:59.000Z

287

Electrorefining cell evaluation  

SciTech Connect (OSTI)

Operational characteristics of the LANL electrorefining cell, a modified LANL electrorefining cell, and an advanced electrorefining cell (known as the CRAC cell) were determined. Average process yields achieved were: 75% for the LANL cell, 82% for the modified LANL cell, and 86% for the CRAC cell. All product metal from the LANL and modified LANL cells was within foundry specifications. Metal from one run in the CRAC cell exceeded foundry specifications for tantalum. The LANL and modified LANL cells were simple in design and operation, but product separation was more labor intensive than with the CRAC cell. The CRAC cell was more complicated in design but remained relatively simple in operation. A decision analysis concluded that the modified LANL cell was the preferred cell. It was recommended that the modified LANL cell be implemented by the Plutonium Recovery Project at Rocky Flats and that development of the CRAC cell continue. 8 refs., 22 figs., 12 tabs.

Bronson, M.C.; Thomas, R.L. (ed.)

1989-04-14T23:59:59.000Z

288

Electrochemistry Cell Model  

Broader source: Energy.gov (indexed) [DOE]

or exceeds all performance goals - Interpreting complex cell electrochemical phenomena - Identification of cell degradation mechanisms Partners (Collaborators) Daniel Abraham,...

289

Excitonic Solar Cells  

Science Journals Connector (OSTI)

Excitonic Solar Cells ... Existing types of solar cells may be divided into two distinct classes:? conventional solar cells, such as silicon p?n junctions, and excitonic solar cells, XSCs. ... Most organic-based solar cells, including dye-sensitized solar cells, DSSCs, fall into the category of XSCs. ...

Brian A. Gregg

2003-05-01T23:59:59.000Z

290

Telecommunications International Cell Phone  

E-Print Network [OSTI]

Telecommunications International Cell Phone 1. Fax completed form to 979.847.1111. 2. If you do will be charged. Date Cell Phone Needed Cell Phone Pick-Up Date Cell Phone User Travel Destination(s) United States Number Destination Country Number Cell Phone Type Digital Satellite Cell Phone Return Date Notes

291

Tocopherol Succinate: Modulation of Antioxidant Enzymes and Oncogene Expression, and Hematopoietic Recovery  

SciTech Connect (OSTI)

Purpose: A class of naturally occurring isoforms of tocopherol (tocols) was shown to have varying degrees of protection when administered before radiation exposure. We recently demonstrated that {alpha}-tocopherol succinate (TS) is a potential radiation prophylactic agent. Our objective in this study was to further investigate the mechanism of action of TS in mice exposed to {sup 60}Co {gamma}-radiation. Methods and Materials: We evaluated the effects of TS on expression of antioxidant enzymes and oncogenes by quantitative RT-PCR in bone marrow cells of {sup 60}Co {gamma}-irradiated mice. Further, we tested the ability of TS to rescue and repopulate hematopoietic stem cells by analyzing bone marrow cellularity and spleen colony forming unit in spleen of TS-injected and irradiated mice. Results: Our results demonstrate that TS modulated the expression of antioxidant enzymes and inhibited expression of oncogenes in irradiated mice at different time points. TS also increased colony forming unit-spleen numbers and bone marrow cellularity in irradiated mice. Conclusions: Results provide additional support for the observed radioprotective efficacy of TS and insight into mechanisms.

Singh, Vijay K., E-mail: singh@afrri.usuhs.mi [Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD (United States); Parekh, Vaishali I.; Brown, Darren S.; Kao, Tzu-Cheg [Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD (United States); Mog, Steven R. [Veterinary Sciences Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD (United States)

2011-02-01T23:59:59.000Z

292

On the bone response to oxidized titanium implants. The role of microporous structure and chemical composition of the surface oxide in enhanced osseointegration.  

E-Print Network [OSTI]

??Background: Titanium implants have been widely used clinically for various types of bone-anchored reconstructions. A thin native oxide film, naturally formed on titanium implants contacts… (more)

Sul, Young-Taeg 1960-

2002-01-01T23:59:59.000Z

293

Stimulation of osteogenic and angiogenic ability of cells on polymers by pulsed laser deposition of uniform akermanite-glass nanolayer  

Science Journals Connector (OSTI)

Abstract Polymer biomaterials have been widely used for bone replacement/regeneration because of their unique mechanical properties and workability. Their inherent low bioactivity makes them lack osseointegration with host bone tissue. For this reason, bioactive inorganic particles have been always incorporated into the matrix of polymers to improve their bioactivity. However, mixing inorganic particles with polymers always results in inhomogeneity of particle distribution in polymer matrix with limited bioactivity. This study sets out to apply the pulsed laser deposition (PLD) technique to prepare uniform akermanite (Ca2MgSi2O7, AKT) glass nanocoatings on the surface of two polymers (non-degradable polysulfone (PSU) and degradable polylactic acid (PDLLA)) in order to improve their surface osteogenic and angiogenic activity. The results show that a uniform nanolayer composed of amorphous AKT particles (?30 nm) of thickness 130 nm forms on the surface of both PSU and PDLLA films with the PLD technique. The prepared AKT-PSU and AKT-PDLLA films significantly improved the surface roughness, hydrophilicity, hardness and apatite mineralization, compared with pure PSU and PDLLA, respectively. The prepared AKT nanocoatings distinctively enhance the alkaline phosphate (ALP) activity and bone-related gene expression (ALP, OCN, OPN and Col I) of bone-forming cells on both PSU and PDLLA films. Furthermore, AKT nanocoatings on two polymers improve the attachment, proliferation, VEGF secretion and expression of proangiogenic factors and their receptors of human umbilical vein endothelial cells (HUVEC). The results suggest that PLD-prepared bioceramic nanocoatings are very useful for enhancing the physicochemical, osteogenic and angiogenic properties of both degradable and non-degradable polymers for application in bone replacement/regeneration.

Chengtie Wu; Dong Zhai; Hongshi Ma; Xiaomin Li; Yali Zhang; Yinghong Zhou; Yongxiang Luo; Yueyue Wang; Yin Xiao; Jiang Chang

2014-01-01T23:59:59.000Z

294

Photoelectrochemical cell  

DOE Patents [OSTI]

A photoelectrochemical cell comprising a sealed container having a light-transmitting window for admitting light into the container across a light-admitting plane, an electrolyte in the container, a photoelectrode in the container having a light-absorbing surface arranged to receive light from the window and in contact with the electrolyte, the surface having a plurality of spaced portions oblique to the plane, each portion having dimensions at least an order of magnitude larger than the maximum wavelength of incident sunlight, the total surface area of the surface being larger than the area of the plane bounded by the container, and a counter electrode in the container in contact with the electrolyte.

Rauh, R. David (Newton, MA); Boudreau, Robert A. (Norton, MA)

1983-06-14T23:59:59.000Z

295

The Influence of Body Position and Microclimate on Ketamine and Metabolite Distribution in Decomposed Skeletal Remains  

Science Journals Connector (OSTI)

......4 Guillot E. , de Mazancourt P., Durigon M., Alvarez J.C. Morphine and 6-acetylmorphine concentrations in blood, brain, spinal cord, bone marrow and bone after lethal acute or chronic diacetylmorphine administration to mice. Forensic Science......

H. M. Cornthwaite; J. H. Watterson

2014-10-01T23:59:59.000Z

296

Mechanisms of impaired osteoblast function during disuse  

E-Print Network [OSTI]

cancellous bone is rapidly formed throughout the marrow of a long bone while hindlimb unloading is the most common method used to produce skeletal unloading. The specific hypotheses of this study were aimed at determining if changes in osteoblast...

Allen, Matthew Robert

2004-11-15T23:59:59.000Z

297

Modified fish-bone model: A simplified MDOF model for simulation of seismic responses of moment resisting frames  

Science Journals Connector (OSTI)

Abstract This paper presents a simplified Multi-Degree-Of-Freedom (MDOF) model through modification of fish-bone model (or generic frame). Modified Fish-Bone (MFB) model is developed through three enhancements: (i) the moment of inertia for half-beams is reduced slightly to modify the assumption of equal rotation at each story joints, (ii) a number of truss elements are inserted to the fish-bone model to simulate flexural deformation of moment frames due to axial elongation and contraction of columns, and (iii) moment–rotation relationship of representative rotational springs is supposed to be bilinear instead of trilinear in order to consider simultaneous yielding at both ends of the beam in moment frames. The proposed model is evaluated with respect to nonlinear dynamic analysis results of three classic moment resisting frames subjected to 94 records of FEMA-440 ground motion data set. Moreover, the adequacy of this model is compared with the fish-bone model and two predictors of nonlinear seismic demand. The statistical study of predicted interstory drift demonstrates the superiority of the proposed model over the fish-bone model and both seismic demand predictors.

A.R. Khaloo; H. Khosravi

2013-01-01T23:59:59.000Z

298

The reproducibility of [sup 109]Cd-based X-ray fluorescence measurements of bone lead  

SciTech Connect (OSTI)

We assessed the reproducibility of X-ray fluorescence-based lead measurements from multiple measurements made on a low-concentration plaster of paris phantom and in five subjects measured five times on two occasions. Over a 6-month period, 220 measurements of the same phantom were obtained and showed a standard deviation of 1.29 [mu]g Pb (g plaster of paris)[sup [minus]1]. The two sets of in vivo measurements were made 10 months apart and revealed a mean standard deviation of 3.4 [mu]Pb (g bone mineral)[sup [minus]1] and 5.1 [mu]g Pb (g bone mineral)[sup [minus]1] for males and females, respectively. Our measured standard deviation exceeded by 20-30% the calculated standard deviation associated with a single measurement both in the phantom and in subjects. This indicates that some variance is introduced during the measurement process. Operator learning and consistency significantly minimized this increased variability. Measured lead concentrations of the left and right tibia in 14 subjects showed no significant differences between legs. As a result, either tibia can be sampled and compared over time. The levels of reproducibility we report here mean that X-ray fluorescence-based determinations of bone lead concentrations are reliable both over the short and long term. Thus, reasonably sized confidence intervals can be placed on detected changes in concentration and should permit acquisition of longitudinal data within a reasonable length of time. 19 refs., 1 fig., 6 tabs.

Gordon, C.L. (Chedoke-McMaster Hospitals, Hamilton, Ontario (Canada)); Webber, C.E.; Chettle, D.R. (McMaster Univ., Hamilton, Ontario (Canada))

1994-08-01T23:59:59.000Z

299

The first cell sorter  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

The first cell sorter The first cell sorter 1663 Los Alamos science and technology magazine Latest Issue:November 2013 All Issues » submit The first cell sorter About fifty years ago, a Los Alamos scientist invented a method-still important in cellular biology labs today-to separate out particular types of cells. November 25, 2013 The first cell sorter Flow cytometry (cell measurement) uses cell sorting to divert cells of a chosen type out of a mixed stream of cells, like the blood cells shown here, for collection and study. Los Alamos invented, and has regularly improved upon, the technology to isolate different kinds of cells. In the early-mid 1960s, Los Alamos physicist Mack Fulwyler invented a device to isolate different types of cells. His invention, still a vital aspect of flow cytometry (cell measurement) in biological laboratories

300

Fuel cell arrangement  

DOE Patents [OSTI]

A fuel cell arrangement is provided wherein cylindrical cells of the solid oxide electrolyte type are arranged in planar arrays where the cells within a plane are parallel. Planes of cells are stacked with cells of adjacent planes perpendicular to one another. Air is provided to the interior of the cells through feed tubes which pass through a preheat chamber. Fuel is provided to the fuel cells through a channel in the center of the cell stack; the fuel then passes the exterior of the cells and combines with the oxygen-depleted air in the preheat chamber.

Isenberg, Arnold O. (Forest Hills Boro, PA)

1987-05-12T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Long bone growth of Mimbres subadults from the NAN Ranch (LA15049), New Mexico  

E-Print Network [OSTI]

of 559 skeletons from three time periods (Late Woodland, Mississippian Acculturated Late Woodland, and Table 2. 2. Indian Knoll maximum long bone length (cm) without epiphysis*. 10 13 14 15 16 17 18 2. 5 ? 3. 5 yr. 3. 5 ? 4. 5 yr. 4. 5 ? 5. 5... yr. 5. 5 ? 6. 5 yr. 6. 5 ? 8 yr. 8 ? 10. 5 yr. 10. 5 ? 11 yr. 11 ? 12 yr. 12 yl ~ 15 yr. + 6 mo. 15 yr. 16 yz' ~ 16. 5 ? 17 yr. 21 yr ~ Age Group Age 1 Birth ? 6 mo. 6 ? 15 mo. 15 ? 24 mo. 4 2 ? 2. 5 yr. Humerus N Mean SD Range 5...

Marek, Marianne

2012-06-07T23:59:59.000Z

302

Hydrogen and Fuel Cell Technologies Update: 2010 Fuel Cell Seminar...  

Broader source: Energy.gov (indexed) [DOE]

Hydrogen and Fuel Cell Technologies Update: 2010 Fuel Cell Seminar and Exposition Hydrogen and Fuel Cell Technologies Update: 2010 Fuel Cell Seminar and Exposition Presentation by...

303

DOE Fuel Cell Technologies Office: 2013 Fuel Cell Seminar and...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

DOE Fuel Cell Technologies Office: 2013 Fuel Cell Seminar and Energy Exposition DOE Fuel Cell Technologies Office: 2013 Fuel Cell Seminar and Energy Exposition Overview of DOE's...

304

DOE Fuel Cell Technologies Office Record 13012: Fuel Cell System...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Fuel Cell Technologies Office Record 13012: Fuel Cell System Cost - 2013 DOE Fuel Cell Technologies Office Record 13012: Fuel Cell System Cost - 2013 This program record from the...

305

Fuel Cell Links  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuel Cell Links Fuel Cell Links The links below are provided as additional resources for fuel-cell-related information. Most of the linked sites are not part of, nor affiliated with, fueleconomy.gov. We do not endorse or vouch for the accuracy of the information found on such sites. Fuel Cell Vehicles and Manufacturers Chevrolet General Motors press release about the Chevrolet Fuel Cell Equinox Ford Ford overview of their hydrogen fuel cell vehicles Honda FCX Clarity official site Hyundai Hyundai press release announcing the upcoming Tucson Fuel Cell Mercedes-Benz Ener-G-Force Fuel-cell-powered concept SUV Nissan Nissan TeRRA concept SUV Toyota Overview of Toyota fuel cell technology Hydrogen- and Fuel-Cell-Related Information and Tools Fuel Cell Vehicles Brief overview of fuel cell vehicles provided by DOE's Alternative Fuels Data Center (AFDC)

306

Photoelectrochemical solar cells  

Science Journals Connector (OSTI)

Photoelectrochemical solar cells ... Plastic Solar Cells: A Multidisciplinary Field To Construct Chemical Concepts from Current Research ... Plastic Solar Cells: A Multidisciplinary Field To Construct Chemical Concepts from Current Research ...

John T. McDevitt

1984-01-01T23:59:59.000Z

307

Hydrogen Fuel Cell Vehicles  

E-Print Network [OSTI]

the membrane for a PEM fuel cell would cost $5/ft (1990$) inmass-produced PEM fuel cell could cost $10/kW or less. Totalparameter for PEM fuel cells: thinner membranes cost less

Delucchi, Mark

1992-01-01T23:59:59.000Z

308

Nanocrystal Solar Cells  

E-Print Network [OSTI]

Nov, 2005). Chapter 4 Hybrid solar cells with 3-dimensional5 All-inorganic nanocrystal solar cells 5.1 Introduction Inoperation of organic based solar cells and distinguish them

Gur, Ilan

2006-01-01T23:59:59.000Z

309

Nanocrystal Solar Cells  

E-Print Network [OSTI]

inorganic nanocrystal solar cells 5.1 Introduction In recentoperation of organic based solar cells and distinguish themThe organic donor-acceptor solar cell relies on a type II

Gur, Ilan

2006-01-01T23:59:59.000Z

310

Hydrogen Fuel Cell Vehicles  

E-Print Network [OSTI]

$ b materials cost, % a Fuel cell stack cost only. Includesof the cost of fuel-cell stacks, 1990$° Cost item GE Swan cAnnual maintenance cost of fuel cell stack and auxiliaries (

Delucchi, Mark

1992-01-01T23:59:59.000Z

311

Hydrogen Fuel Cell Vehicles  

E-Print Network [OSTI]

Hydrogen Fuel Cell Vehicles UCD-ITS-RR-92-14 September byet al. , 1988,1989 HYDROGEN FUEL-CELL VEHICLES: TECHNICALIn the FCEV, the hydrogen fuel cell could supply the "net"

Delucchi, Mark

1992-01-01T23:59:59.000Z

312

Thermal Management of Solar Cells  

E-Print Network [OSTI]

D. Mills, "Cooling of photovoltaic cells under concentratedelectric performance of a photovoltaic cells by cooling andSolar Cell A photovoltaic cell is a semiconductor that

Saadah, Mohammed Ahmed

2013-01-01T23:59:59.000Z

313

Novel application of stem cell-derived factors for periodontal regeneration  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Mesenchymal stem cells (MSCs) secrete a variety of cytokines. Black-Right-Pointing-Pointer Cytokines were detected in conditioned medium from cultured MSCs (MSC-CM). Black-Right-Pointing-Pointer MSC-CM enhanced activation of dog MSCs and periodontal ligament cells. Black-Right-Pointing-Pointer MSC-CM significantly promoted alveolar bone and cementum regeneration. Black-Right-Pointing-Pointer Multiple cytokines contained in MSC-CM promote periodontal regeneration. -- Abstract: The effect of conditioned medium from cultured mesenchymal stem cells (MSC-CM) on periodontal regeneration was evaluated. In vitro, MSC-CM stimulated migration and proliferation of dog MSCs (dMSCs) and dog periodontal ligament cells (dPDLCs). Cytokines such as insulin-like growth factor, vascular endothelial growth factor, transforming growth factor-{beta}1, and hepatocyte growth factor were detected in MSC-CM. In vivo, one-wall critical-size, intrabony periodontal defects were surgically created in the mandible of dogs. Dogs with these defects were divided into three groups that received MSC-CM, PBS, or no implants. Absorbable atelo-collagen sponges (TERUPLUG Registered-Sign ) were used as a scaffold material. Based on radiographic and histological observation 4 weeks after transplantation, the defect sites in the MSC-CM group displayed significantly greater alveolar bone and cementum regeneration than the other groups. These findings suggest that MSC-CM enhanced periodontal regeneration due to multiple cytokines contained in MSC-CM.

Inukai, Takeharu, E-mail: t-inukai@med.nagoya-u.ac.jp [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan)] [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan); Katagiri, Wataru, E-mail: w-kat@med.nagoya-u.ac.jp [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan)] [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan); Yoshimi, Ryoko, E-mail: lianzi@med.nagoya-u.ac.jp [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan)] [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan); Osugi, Masashi, E-mail: masashi@med.nagoya-u.ac.jp [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan)] [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan); Kawai, Takamasa, E-mail: takamasa@med.nagoya-u.ac.jp [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan)] [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan); Hibi, Hideharu, E-mail: hibihi@med.nagoya-u.ac.jp [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan)] [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan); Ueda, Minoru, E-mail: mueda@med.nagoya-u.ac.jp [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan)] [Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine (Japan)

2013-01-11T23:59:59.000Z

314

Origin of the pattern of trabecular bone: An experiment and a model  

Science Journals Connector (OSTI)

As a result of an experiment in which the development of a mineral phase in the rabbit embryo was observed, a model is proposed to explain the mechanism that controls the place of precipitation of crystals in mineralizing tissue. The reaction-diffusion equations for the specified compounds are formulated and solved. Among a variety of compounds the concentrations of carbon dioxide, oxygen, HCO3- ions, H+ ions, calcium, and inorganic phosphorus are evaluated.? CO2, HCO3- ions, and H+ ions, are distinguished due to their key role in the maintenance of the pH value. The local concentration of oxygen is the pivot factor that controls the metabolic rate, i.e., production of CO2. Next the supersaturation was estimated on the basis of the calculated values of pH and the concentrations of calcium and inorganic phosphorus. It is assumed that the synthesis of the organic matrix breaks the metastable equilibrium with respect to spontaneous precipitation and leads to the deposition of minerals. It was found that the geometry of the vasculature determines the shape of primitive trabecular bone (woven bone) while the value of the diffusion coefficient may be the key factor indicating the possibility of mineralization under the control of a living organism.

Zbis?aw Tabor; Eugeniusz Rokita; Tadeusz Cichocki

2002-11-13T23:59:59.000Z

315

Overexpression of DMP1 accelerates mineralization and alters cortical bone biomechanical properties in vivo  

SciTech Connect (OSTI)

Dentin matrix protein-1 (DMP1) is a key regulator of biomineralization. Here, we examine changes in structural, geometric, and material properties of cortical bone in a transgenic mouse model overexpressing DMP1. Micro-computed tomography and three-point bending were performed on 90 femora of wild type and transgenic mice at 1, 2, 4, and 6 months. Fourier transform infrared imaging was performed at 2 months. We found that the transgenic femurs were longer (p < 0.01), more robust in cross-section (p < 0.05), stronger (p < 0.05), but had less post-yield strain and displacement (p < 0.01), and higher tissue mineral density (p < 0.01) than the wild type femurs at 1 and 2 months. At 2 months, the transgenic femurs also had a higher mineral-to-matrix ratio (p < 0.05) and lower carbonate substitution (p < 0.05) compared to wild type femurs. These findings indicate that increased mineralization caused by overexpressing DMP1 led to increased structural cortical bone properties associated with decreased ductility during the early post-natal period.

Bhatia A.; Miller L.; Albazza, M.; Espinoza Orias, A.A.; Inoue, N.; Acerbo, A.; George, A.; Sumner, D.R.

2011-09-29T23:59:59.000Z

316

Snail modulates cell metabolism in MDCK cells  

SciTech Connect (OSTI)

Highlights: ? MDCK/snail cells were more sensitive to glucose deprivation than MDCK/neo cells. ? MDCK/snail cells had decreased oxidative phosphorylation, O{sub 2} consumption and ATP content. ? TCA cycle enzyme activity, but not expression, was lower in MDCK/snail cells. ? MDCK/snail cells showed reduced PDH activity and increased PDK1 expression. ? MDCK/snail cells showed reduced expression of GLS2 and ACLY. -- Abstract: Snail, a repressor of E-cadherin gene transcription, induces epithelial-to-mesenchymal transition and is involved in tumor progression. Snail also mediates resistance to cell death induced by serum depletion. By contrast, we observed that snail-expressing MDCK (MDCK/snail) cells undergo cell death at a higher rate than control (MDCK/neo) cells in low-glucose medium. Therefore, we investigated whether snail expression influences cell metabolism in MDCK cells. Although gylcolysis was not affected in MDCK/snail cells, they did exhibit reduced pyruvate dehydrogenase (PDH) activity, which controls pyruvate entry into the tricarboxylic acid (TCA) cycle. Indeed, the activity of multiple enzymes involved in the TCA cycle was decreased in MDCK/snail cells, including that of mitochondrial NADP{sup +}-dependent isocitrate dehydrogenase (IDH2), succinate dehydrogenase (SDH), and electron transport Complex II and Complex IV. Consequently, lower ATP content, lower oxygen consumption and increased survival under hypoxic conditions was also observed in MDCK/snail cells compared to MDCK/neo cells. In addition, the expression and promoter activity of pyruvate dehydrogenase kinase 1 (PDK1), which phosphorylates and inhibits the activity of PDH, was increased in MDCK/snail cells, while expression levels of glutaminase 2 (GLS2) and ATP-citrate lyase (ACLY), which are involved in glutaminolysis and fatty acid synthesis, were decreased in MDCK/snail cells. These results suggest that snail modulates cell metabolism by altering the expression and activity of key enzymes. This results in enhanced glucose dependency and leads to cell death under low-glucose conditions. On the other hand, the reduced requirements for oxygen and nutrients from the surrounding environment, might confer the resistance to cell death induced by hypoxia and malnutrition.

Haraguchi, Misako, E-mail: haraguci@m3.kufm.kagoshima-u.ac.jp [Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan)] [Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan); Indo, Hiroko P. [Department of Maxillofacial Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan)] [Department of Maxillofacial Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan); Iwasaki, Yasumasa [Health Care Center, Kochi University, Kochi 780-8520 (Japan)] [Health Care Center, Kochi University, Kochi 780-8520 (Japan); Iwashita, Yoichiro [Department of Maxillofacial Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan)] [Department of Maxillofacial Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan); Fukushige, Tomoko [Department of Dermatology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan)] [Department of Dermatology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan); Majima, Hideyuki J. [Department of Maxillofacial Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan)] [Department of Maxillofacial Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan); Izumo, Kimiko; Horiuchi, Masahisa [Department of Environmental Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan)] [Department of Environmental Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan); Kanekura, Takuro [Department of Dermatology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan)] [Department of Dermatology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan); Furukawa, Tatsuhiko [Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan)] [Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan); Ozawa, Masayuki [Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan)] [Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544 (Japan)

2013-03-22T23:59:59.000Z

317

Fuel Cells at NASCAR  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Fuel Cells at NASCAR Ned Stetson U.S. Department of Energy Fuel Cell Technologies Office Catherine Kummer - NASCAR Green Norm Bessette - Acumentrics Question and Answer * Please...

318

Automotive Fuel Cell Corporation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

with AFCC, a private joint venture company in Canada, formed by combining the automotive fuel cell business of Ballard Power Systems with the fuel cell stack development...

319

SFTEL: Flow Cell | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Flow Cell EMSL's Subsurface Flow and Transport Experimental Laboratory offers several meter-scale flow cells and columns for research in saturated and unsaturated porous media....

320

Microfluidic fuel cells.  

E-Print Network [OSTI]

??Microfluidic fuel cell architectures are presented in this thesis. This work represents the mechanical and microfluidic portion of a microfluidic biofuel cell project. While the… (more)

Kjeang, Erik

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Fuel Cell Technologies Office: Fuel Cell Technical Publications  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cell Technical Cell Technical Publications to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technical Publications on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technical Publications on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technical Publications on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technical Publications on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technical Publications on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technical Publications on AddThis.com... Publications Program Publications Technical Publications Hydrogen Fuel Cells Safety, Codes & Standards Market Analysis Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings

322

Mechanosensitivity of human osteosarcoma cells and phospholipase C {beta}2 expression  

SciTech Connect (OSTI)

Bone adapts to mechanical load by osteosynthesis, suggesting that osteoblasts might respond to mechanical stimuli. We therefore investigated cell proliferation and phospholipase C (PLC) expression in osteoblasts. One Hertz uniaxial stretching at 4000 {mu}strains significantly increased the proliferation rates of human osteoblast-like osteosarcoma cell line MG-63 and primary human osteoblasts. However, U-2/OS, SaOS-2, OST, and MNNG/HOS cells showed no significant changes in proliferation rate. We investigated the expression pattern of different isoforms of PLC in these cell lines. We were able to detect PLC {beta}1, {beta}3, {gamma}1, {gamma}2, and {delta}1 in all cells, but PLC {beta}2 was only detectable in the mechanosensitive cells. We therefore investigated the possible role of PLC {beta}2 in mechanotransduction. Inducible antisense expression for 24 h inhibited the translation of PLC {beta}1 in U-2/OS cells by 35% and PLC {beta}2 in MG-63 by 29%. Fluid shear flow experiments with MG-63 lacking PLC {beta}2 revealed a significantly higher level of cells losing attachment to coverslips and a significantly lower number of cells increasing intracellular free calcium.

Hoberg, M. [Department of Orthopaedics, University of Tuebingen (Germany)]. E-mail: Maik.Hoberg@med.uni-tuebingen.de; Gratz, H.-H. [Experimental Orthopaedics and Biomechanics, Phillips-University of Marburg (Germany); Noll, M. [Experimental Orthopaedics and Biomechanics, Phillips-University of Marburg (Germany); Jones, D.B. [Experimental Orthopaedics and Biomechanics, Phillips-University of Marburg (Germany)

2005-07-22T23:59:59.000Z

323

Chemopreventive activity of compounds extracted from Casearia sylvestris (Salicaceae) Sw against DNA damage induced by particulate matter emitted by sugarcane burning near Araraquara, Brazil  

SciTech Connect (OSTI)

Ethanolic extract of Casearia sylvestris is thought to be antimutagenic. In this study, we attempted to determine whether this extract and casearin X (a clerodane diterpene from C. sylvestris) are protective against the harmful effects of airborne pollutants from sugarcane burning. To that end, we used the Tradescantia micronucleus test in meiotic pollen cells of Tradescantia pallida, the micronucleus test in mouse bone marrow cells, and the comet assay in mouse blood cells. The mutagenic compound was total suspended particulate (TSP) from air. For the Tradescantia micronucleus test, T. pallida cuttings were treated with the extract at 0.13, 0.25, or 0.50 mg/ml. Subsequently, TSP was added at 0.3 mg/ml, and tetrads from the inflorescences were examined for micronuclei. For the micronucleus test in mouse bone marrow cells and the comet assay in mouse blood cells, Balb/c mice were treated for 15 days with the extract—3.9, 7.5, or 15.0 mg/kg body weight (BW)—or with casearin X—0.3, 0.25, or 1.2 mg/kg BW—after which they received TSP (3.75 mg/kg BW). In T. pallida and mouse bone marrow cells, the extract was antimutagenic at all concentrations tested. In mouse blood cells, the extract was antigenotoxic at all concentrations, whereas casearin X was not antimutagenic but was antigenotoxic at all concentrations. We conclude that C. sylvestris ethanolic extract and casearin X protect DNA from damage induced by airborne pollutants from sugarcane burning. -- Highlights: ? We assessed DNA protection of C. sylvestris ethanolic extract. ? We assessed DNA protection of casearin X. ? We used Tradescantia pallida micronucleus test as screening. ? We used comet assay and micronucleus test in mice. ? The compounds protected DNA against sugar cane burning pollutants.

Prieto, A.M. [UNESP — Univ. Estadual Paulista, College of Pharmaceutical Sciences, Department of Clinical Analysis, Rua Expedicionários do Brasil, 1621, Araraquara (Brazil)] [UNESP — Univ. Estadual Paulista, College of Pharmaceutical Sciences, Department of Clinical Analysis, Rua Expedicionários do Brasil, 1621, Araraquara (Brazil); Santos, A.G. [UNESP — Univ. Estadual Paulista, College of Pharmaceutical Sciences, Department of Natural Principles and Toxicology, Rodovia Araraquara-Jau, km 01, Araraquara (Brazil)] [UNESP — Univ. Estadual Paulista, College of Pharmaceutical Sciences, Department of Natural Principles and Toxicology, Rodovia Araraquara-Jau, km 01, Araraquara (Brazil); Csipak, A.R.; Caliri, C.M.; Silva, I.C. [UNESP — Univ. Estadual Paulista, College of Pharmaceutical Sciences, Department of Clinical Analysis, Rua Expedicionários do Brasil, 1621, Araraquara (Brazil)] [UNESP — Univ. Estadual Paulista, College of Pharmaceutical Sciences, Department of Clinical Analysis, Rua Expedicionários do Brasil, 1621, Araraquara (Brazil); Arbex, M.A. [UNIFESP — Federal University of São Paulo, Paulista College of Medicine, Department of Internal Medicine, Rua Pedro de Toledo, 720, São Paulo (Brazil)] [UNIFESP — Federal University of São Paulo, Paulista College of Medicine, Department of Internal Medicine, Rua Pedro de Toledo, 720, São Paulo (Brazil); Silva, F.S.; Marchi, M.R.R. [UNESP — Univ. Estadual Paulista, Chemistry Institute, Department of Analytical Chemistry, Rua Francisco Degni, S/N, Araraquara (Brazil)] [UNESP — Univ. Estadual Paulista, Chemistry Institute, Department of Analytical Chemistry, Rua Francisco Degni, S/N, Araraquara (Brazil); Cavalheiro, A.J.; Silva, D.H.S.; Bolzani, V.S. [UNESP — Univ. Estadual Paulista, Chemistry Institute, Department of Organic Chemistry, Rua Francisco Degni, S/N, Araraquara (Brazil)] [UNESP — Univ. Estadual Paulista, Chemistry Institute, Department of Organic Chemistry, Rua Francisco Degni, S/N, Araraquara (Brazil); Soares, C.P., E-mail: soarescp@hotmail.com [UNESP — Univ. Estadual Paulista, College of Pharmaceutical Sciences, Department of Clinical Analysis, Rua Expedicionários do Brasil, 1621, Araraquara (Brazil)

2012-12-15T23:59:59.000Z

324

Fuel Cell Technologies Office: Reversible Fuel Cells Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Reversible Fuel Cells Reversible Fuel Cells Workshop to someone by E-mail Share Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on Facebook Tweet about Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on Twitter Bookmark Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on Google Bookmark Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on Delicious Rank Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on Digg Find More places to share Fuel Cell Technologies Office: Reversible Fuel Cells Workshop on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings Annual Merit Review Proceedings Workshop & Meeting Proceedings

325

Electrocatalysts for Fuel Cells  

Science Journals Connector (OSTI)

...research-article Electrocatalysts for Fuel Cells G. J. K. Acres G. A. Hards The...physical composition of the catalysts used in fuel cells are determined by the type of cell...operating conditions. The six types of fuel cell presently in use or under development...

1996-01-01T23:59:59.000Z

326

Interspecic scaling of the hindlimb skeleton in lizards, crocodilians, felids and canids: does limb bone shape correlate  

E-Print Network [OSTI]

limb bone shape correlate with limb posture? Richard W. Blob* Committee on Evolutionary Biology-phylogenetic statistical methods and phylogenetically independent contrasts. Comparisons with theoretical models indicate to such an extent that for the femur and tibia safety factors in shear are approximately half as great as safety

Blob, Richard W.

327

Numerical investigation into blood clotting at the bone-dental implant interface in the presence of an electrical stimulus  

Science Journals Connector (OSTI)

The insertion of a dental implant activates a sequence of wound healing events ending with bone formation and implant osseointegration. This sequence starts with the blood coagulation process and the formation of a fibrin network that detains spilt blood. ... Keywords: Blood clotting, Dental implant, Electrical stimulation, Mathematical model

J. C. Vanegas-Acosta; D. A. Garzón-Alvarado; V. Lancellotti

2013-12-01T23:59:59.000Z

328

DESIGN OF FOAM COVERING FOR ROBOTIC ARMS TO ENSURE HUMAN SAFETY Lingqi Zeng and Gary M. Bone  

E-Print Network [OSTI]

DESIGN OF FOAM COVERING FOR ROBOTIC ARMS TO ENSURE HUMAN SAFETY Lingqi Zeng and Gary M. Bone neglected coupling of the human head to the torso and the coupling of the robot arm to its base. The impact and maintain, which limits their applicability. Using foam to cover the robot arm surface is a simple

Bone, Gary

329

Physico-chemical characterization and in vitro biological evaluation of pure SiHA for bone tissue engineering application  

E-Print Network [OSTI]

Supérieure des Mines de Saint-Etienne, CIS-EMSE, CNRS: FRE3312, F-42023 158 Cours Fauriel, SaintHA surface. Introduction Large bone defects resulting from trauma, cancer or malformations remain significant the real effects of Si substitution on the biological activity of HA in biological environment [6-8]. hal

Paris-Sud XI, Université de

330

Fracture Mechanisms of Bone: A Comparative Study between Antler and Bovine Femur , F.A. Sheppard2  

E-Print Network [OSTI]

Fracture Mechanisms of Bone: A Comparative Study between Antler and Bovine Femur P.Y. Chen1 , F, University of California, San Diego, La Jolla, CA 92093-0411, U.S.A. ABSTRACT In this study, fracture conditions to study the effects of fiber orientation and hydration. Fracture toughness results

McKittrick, Joanna

331

Bone Acquisition in Healthy Children and Adolescents: Comparisons of Dual-Energy X-Ray Absorptiometry and  

E-Print Network [OSTI]

and Radiology and Division of Endocrinology and Metabolism, Childrens Hospital Los Angeles, Los Angeles pediatric bone measurements using DXA. Height, weight, body mass index, skeletal age, and Tanner stageBMD in healthy children (2­13). Although DXA studies in pediatrics have provided much information re- garding

Valero-Cuevas, Francisco

332

The degree of bone mineralization is maintained with single intravenous bisphosphonates in aged estrogen-deficient rats and  

E-Print Network [OSTI]

estrogen-deficient rats and is a strong predictor of bone strength Wei Yao a , Zhiqiang Cheng a , Kurt J rats were ovariectomized and treated with a single dose of risedronate (intravenous, iv, 500 g was not changed with OVX or with anti-resorptive treatments. In conclusion, in the aged estrogen-deficient rat

Ritchie, Robert

333

Evaluation of ultrasound transmission velocity and 3-dimensional radiology in different bone types for dental implantology: a comparative ex vivo study  

Science Journals Connector (OSTI)

Objective To evaluate ultrasound transmission velocity (UTV) for assessment of mechanical bone quality, an ex vivo comparison of different bone types measured with UTV, 2-dimensional (2D) histomorphometry and with 3-dimensional (3D) radiology (cone-beam computerized tomography [CBCT], computerized microtomography [?CT]) was conducted. Study Design Clinical cortical, cancellous, and mixed bone (each n = 6) was measured via UTV (m/s), CBCT (white pixel/black pixel ratio [WP/BP]), ?CT (bone volume/total volume [?BV/TV]), and histomorphometry (bone volume/total volume [hBV/TV]). UTV values were correlated with 2D-histomorphometry and 3D-radiologic results. Results For the cortical, cancellous, and mixed bone samples, respectively, UTV values were 1,945.17, 1,266.9,and 1472.2 m/s, WP/BP quotients were 0.96, 0.15, and 0.33, ?BV/TV quotients were 0.94, 0.2, and 0.47, and hBV/TV quotients were 0.96, 0.24 and 0.39. Significant correlations between UTV and the other methods were seen (P < .0001). Conclusions Similar to the other methods, UTV is able to discriminate between different bone types ex vivo.

Peer W. Kämmerer; Vinay V. Kumar; Dan Brüllmann; Hermann Götz; Peter H. Kann; Bilal Al-Nawas; Marcus O. Klein

2013-01-01T23:59:59.000Z

334

FCT Fuel Cells: Basics  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Basics to someone by E-mail Basics to someone by E-mail Share FCT Fuel Cells: Basics on Facebook Tweet about FCT Fuel Cells: Basics on Twitter Bookmark FCT Fuel Cells: Basics on Google Bookmark FCT Fuel Cells: Basics on Delicious Rank FCT Fuel Cells: Basics on Digg Find More places to share FCT Fuel Cells: Basics on AddThis.com... Home Basics Current Technology DOE R&D Activities Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Technology Validation Manufacturing Codes & Standards Education Systems Analysis Contacts Basics Photo of a fuel cell stack A fuel cell uses the chemical energy of hydrogen to cleanly and efficiently produce electricity with water and heat as byproducts. (How much water?) Fuel cells are unique in terms of the variety of their potential applications; they can provide energy for systems as large as a utility

335

Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer  

Science Journals Connector (OSTI)

...Assessments. Patients underwent baseline tumor imaging, with computed tomography or magnetic resonance imaging of the chest, abdomen, and pelvis. Brain and bone scans were obtained at baseline if disease at these sites was suspected. Tumor assessments were performed by the investigators every 8 weeks... About 1% of non–small-cell lung cancers have ROS1 rearrangements. This oncogene is inhibited by crizotinib. In a cohort of 50 patients with ROS1-rearranged lung cancer, crizotinib induced responses in 72%; the median duration of response was nearly a year and a half.

Shaw A.T.; Ou S.-H.I.; Bang Y.-J.

2014-11-20T23:59:59.000Z

336

The effect of excitation and preparation pulses on nonslice selective 2D UTE bicomponent analysis of bound and free water in cortical bone at 3T  

SciTech Connect (OSTI)

Purpose: The purpose of this study was to investigate the effect of excitation, fat saturation, long T2 saturation, and adiabatic inversion pulses on ultrashort echo time (UTE) imaging with bicomponent analysis of bound and free water in cortical bone for potential applications in osteoporosis. Methods: Six bovine cortical bones and six human tibial midshaft samples were harvested for this study. Each bone sample was imaged with eight sequences using 2D UTE imaging at 3T with half and hard excitation pulses, without and with fat saturation, long T2 saturation, and adiabatic inversion recovery (IR) preparation pulses. Single- and bicomponent signal models were utilized to calculate the T2{sup *}s and/or relative fractions of short and long T2{sup *}s. Results: For all bone samples UTE T2{sup *} signal decay showed bicomponent behavior. A higher short T2{sup *} fraction was observed on UTE images with hard pulse excitation compared with half pulse excitation (75.6% vs 68.8% in bovine bone, 79.9% vs 73.2% in human bone). Fat saturation pulses slightly reduced the short T2{sup *} fraction relative to regular UTE sequences (5.0% and 2.0% reduction, respectively, with half and hard excitation pulses for bovine bone, 6.3% and 8.2% reduction, respectively, with half and hard excitation pulses for human bone). Long T2 saturation pulses significantly reduced the long T2{sup *} fraction relative to regular UTE sequence (18.9% and 17.2% reduction, respectively, with half and hard excitation pulses for bovine bone, 26.4% and 27.7% reduction, respectively, with half and hard excitation pulses for human bone). With IR-UTE preparation the long T2{sup *} components were significantly reduced relative to regular UTE sequence (75.3% and 66.4% reduction, respectively, with half and hard excitation pulses for bovine bone, 87.7% and 90.3% reduction, respectively, with half and hard excitation pulses for human bone). Conclusions: Bound and free water T2{sup *}s and relative fractions can be assessed using UTE bicomponent analysis. Long T2{sup *} components are affected more by long T2 saturation and IR pulses, and short T2{sup *} components are affected more by fat saturation pulses.

Li, Shihong [Department of Radiology, University of California, San Diego, California 92103-8226 (United States) [Department of Radiology, University of California, San Diego, California 92103-8226 (United States); Department of Radiology, Hua Dong Hospital, Fudan University, Shanghai 200040 (China); Yancheng Medical College, Jiangsu (China); The First People's Hospital of Yancheng City, Jiangsu 224005 (China); Chang, Eric Y.; Chung, Christine B. [VA San Diego Healthcare System, San Diego, California 92161 and Department of Radiology, University of California, San Diego, California 92103-8226 (United States)] [VA San Diego Healthcare System, San Diego, California 92161 and Department of Radiology, University of California, San Diego, California 92103-8226 (United States); Bae, Won C.; Du, Jiang, E-mail: jiangdu@ucsd.edu [Department of Radiology, University of California, San Diego, California 92103-8226 (United States)] [Department of Radiology, University of California, San Diego, California 92103-8226 (United States); Hua, Yanqing [Department of Radiology, Hua Dong Hospital, Fudan University, Shanghai 200040 (China)] [Department of Radiology, Hua Dong Hospital, Fudan University, Shanghai 200040 (China); Zhou, Yi [The First People's Hospital of Yancheng City, Jiangsu 224005 (China)] [The First People's Hospital of Yancheng City, Jiangsu 224005 (China)

2014-02-15T23:59:59.000Z

337

Abstract P1-13-08: A Cross-Sectional Study Evaluating Bone Quantity and Quality in Women with Bone Metastases from Breast Cancer  

Science Journals Connector (OSTI)

...investigate low linear energy transfer (LET) radiation-induced...target size and radiation quality and are likely to have...involved high linear energy transfer (LET) alpha-particles...target size and radiation quality and are likely to have...Humans Hybrid Cells Linear Energy Transfer Magnetics Mutagenesis...

OC Freedman; E Amir; AM Cheung; H Hu; E Lee; G Dranitsaris; and MJ. Clemons

2010-12-15T23:59:59.000Z

338

HISTORY | Fuel Cells  

Science Journals Connector (OSTI)

Together with the electric motor, dynamo, gas turbine, internal combustion engine, and the fused salt electrolysis of aluminum, the industrial revolution of the nineteenth century brought about the fuel cell – the silent or cold combustion of fossil fuels by the electrochemical oxidation with atmospheric oxygen to water and carbon dioxide. Wilhelm Ostwald, in 1894, emphasized the high efficiency and the nonpolluting properties of the direct conversion of chemical energy into electricity – in contrast to the then combination of steam engine and dynamo, which reached only about 10% efficiency. Direct coal fuel cells designed for the propulsion of ships, however, have not become a reality so far. Instead of fuel cells and batteries, internal combustion engines determined the nineteenth- and twentieth- century technological landscape. Against the background of the oil crisis and the long-term scarcity of natural gas, crude oil, and coal, new hopes have focused on fuel cell technology, which saw first early splendid applications during the space programs of the 1960s, in submarines since the 1980s, and in experimental zero-emission vehicles (ZEVs) since the 1990s. This article outlines (1) early insights about energy conversion: Grove's cell, direct conversion of coal and indirect fuel cells; (2) historical roots of alkaline fuel cells: the discovery of gas diffusion electrodes; low-pressure alkaline fuel cell conquer spacecrafts and submarines; (3) polymer electrolyte fuel cells: solid polymer technology, electric vehicles, direct methanol fuel-cell, stationary power systems and portable polymer electrolyte membrane fuel cell systems; (4) phosphoric acid fuel cell (PAFC): acid fuel cells, PAFC plants in Japan, gasoline fuel cells; and (5) high-temperature fuel cells: molten carbonate fuel cell and solid oxide fuel cell.

P. Kurzweil

2009-01-01T23:59:59.000Z

339

Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 is Expressed inOsteoblasts and Regulated by PTH  

SciTech Connect (OSTI)

Highlights: •CARP-1 is identified for the first time in bone cells. •PTH downregulates CARP-1 expression in differentiated osteoblasts. •PTH displaces CARP-1 from nucleus to the cytoplasm in differentiated osteoblasts. •Downregulation of CARP-1 by PTH involves PKA, PKC and P-p38 MAPK pathways. -- Abstract: Bone mass is dependent on osteoblast proliferation, differentiation and life-span of osteoblasts. Parathyroid hormone (PTH) controls osteoblast cell cycle regulatory proteins and suppresses mature osteoblasts apoptosis. Intermittent administration of PTH increases bone mass but the mechanism of action are complex and incompletely understood. Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 (aka CCAR1) is a novel transducer of signaling by diverse agents including cell growth and differentiation factors. To gain further insight into the molecular mechanism, we investigated involvement of CARP-1 in PTH signaling in osteoblasts. Immunostaining studies revealed presence of CARP-1 in osteoblasts and osteocytes, while a minimal to absent levels were noted in the chondrocytes of femora from 10 to 12-week old mice. Treatment of 7-day differentiated MC3T3-E1 clone-4 (MC-4) mouse osteoblastic cells and primary calvarial osteoblasts with PTH for 30 min to 5 h followed by Western blot analysis showed 2- to 3-fold down-regulation of CARP-1 protein expression in a dose- and time-dependent manner compared to the respective vehicle treated control cells. H-89, a Protein Kinase A (PKA) inhibitor, suppressed PTH action on CARP-1 protein expression indicating PKA-dependent mechanism. PMA, a Protein Kinase C (PKC) agonist, mimicked PTH action, and the PKC inhibitor, GF109203X, partially blocked PTH-dependent downregulation of CARP-1, implying involvement of PKC. U0126, a Mitogen-Activated Protein Kinase (MAPK) Kinase (MEK) inhibitor, failed to interfere with CARP-1 suppression by PTH. In contrast, SB203580, p38 inhibitor, attenuated PTH down-regulation of CARP-1 suggesting that PTH utilized an Extracellular Signal Regulated Kinase (ERK)-independent but p38 dependent pathway to regulate CARP-1 protein expression in osteoblasts. Immunofluorescence staining of differentiated osteoblasts further revealed nuclear to cytoplasmic translocation of CARP-1 protein following PTH treatment. Collectively, our studies identified CARP-1 for the first time in osteoblasts and suggest its potential role in PTH signaling and bone anabolic action.

Sharma, Sonali; Mahalingam, Chandrika D.; Das, Varsha [Department of Internal Medicine/Endocrinology, Wayne State University School of Medicine, Detroit, MI 48201 (United States)] [Department of Internal Medicine/Endocrinology, Wayne State University School of Medicine, Detroit, MI 48201 (United States); Jamal, Shazia [Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201 (United States)] [Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201 (United States); Levi, Edi [Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201 (United States) [Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201 (United States); Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201 (United States); Rishi, Arun K. [Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201 (United States) [Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201 (United States); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201 (United States); VA Medical Center, Wayne State University School of Medicine, Detroit, MI 48201 (United States); Datta, Nabanita S., E-mail: ndatta@med.wayne.edu [Department of Internal Medicine/Endocrinology, Wayne State University School of Medicine, Detroit, MI 48201 (United States); Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201 (United States); Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI 48201 (United States)

2013-07-12T23:59:59.000Z

340

Fuel Cell Technologies Overview  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

4/3/2012 4/3/2012 eere.energy.gov Fuel Cell Technologies Overview Flow Cell Workshop Washington, DC Dr. Sunita Satyapal & Dr. Dimitrios Papageorgopoulos U.S. Department of Energy Fuel Cell Technologies Program 3/7/2011 Flow Cells for Energy Storage Workshop Purpose To understand the applied research and development needs and the grand challenges for the use of flow cells as energy-storage devices. Objectives 1. Understand the needs for applied research from stakeholders. 2. Gather input for future development of roadmaps and technical targets for flow cells for various applications. 3. Identify grand challenges and prioritize R&D needs. Flow cells combine the unique advantages of batteries and fuel cells and can offer benefits for multiple energy storage applications.

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

FUEL CELLS RALLY  

Science Journals Connector (OSTI)

FUEL CELLS RALLY ... No, this car has composite tanks capable of storing 8 kg of hydrogen. ... It's General Motors' Sequel, a fuel-cell concept car unveiled earlier this month at the North American International Auto Show in Detroit. ...

ALEXANDER H. TULLO

2005-01-31T23:59:59.000Z

342

Semitransparent organic solar cells  

Science Journals Connector (OSTI)

The organic solar cell technology has attracted great interests due to ... low cost solution process capability. Bulk heterojunction organic solar cells offer a potentially much cheaper alternative way to harness...

Furong Zhu

2014-03-01T23:59:59.000Z

343

What determines cell size?  

E-Print Network [OSTI]

as: Marshall WF, et al. : What determines cell size? BMC7007/10/101 FORUM Open Access What determines cell size?biologists have been wondering what determines the size of

2012-01-01T23:59:59.000Z

344

fuel cells | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

fuel cells fuel cells Leads No leads are available at this time. The Molecular Bond: October 2014 The Molecular Bond newsletter banner October 2014 FROM THE DIRECTOR Read more...

345

NANOCOMPOSITE ENABLED SENSITIZED SOLAR CELL  

E-Print Network [OSTI]

in all thin-film solar cell technologies is that absorbancecells. These emerging solar cell technologies have undergonethe various solar cell technologies and their progress as

Phuyal, Dibya

2012-01-01T23:59:59.000Z

346

NANOCOMPOSITE ENABLED SENSITIZED SOLAR CELL  

E-Print Network [OSTI]

by Dye-Sensitized Photovoltaic cells. Inorganic Chemistry,by Dye-Sensitized Photovoltaic Cells. Inorganic ChemistryThe characteristics of a photovoltaic cell. Generally,

Phuyal, Dibya

2012-01-01T23:59:59.000Z

347

DOE Fuel Cell Technologies Office  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

DOE Fuel Cell Technologies Office Fuel Cell Seminar & Energy Exposition Columbus, Ohio Dr. Sunita Satyapal Director Fuel Cell Technologies Office Energy Efficiency and Renewable...

348

Fuel Cells | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Fuel Cells Fuel Cells Fuel cells are an important enabling technology for the nation's energy portfolio and have the potential to revolutionize the way we power our nation,...

349

Webinar: Fuel Cell Buses  

Broader source: Energy.gov [DOE]

Video recording and text version of the webinar titled, Fuel Cell Buses, originally presented on September 12, 2013.

350

Electrochemistry Cell Model  

Broader source: Energy.gov [DOE]

2012 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

351

Photo-Electric Cells  

Science Journals Connector (OSTI)

... be measured, and its variation studied with variation of the incident light. Again, the photo-electric current may be amplified by valve circuits used outside the cell, or may ... to the infra-red, in which the active substance is oxidised thallium sulphide), barium photo-electric cells, sodium, and selenium cells.

ALLAN FERGUSON

1930-06-21T23:59:59.000Z

352

Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Market Transformation Market Transformation Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies to someone by E-mail Share Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Facebook Tweet about Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Twitter Bookmark Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Google Bookmark Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Delicious Rank Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Digg Find More places to share Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on AddThis.com... Early Adoption of Fuel Cells Early Market Applications for Fuel Cells

353

California: TetraCell Silicon Solar Cell Improves Efficiency...  

Energy Savers [EERE]

California: TetraCell Silicon Solar Cell Improves Efficiency, Wins R&D 100 Award California: TetraCell Silicon Solar Cell Improves Efficiency, Wins R&D 100 Award August 16, 2013 -...

354

DOE Fuel Cell Technologies Office Record 14012: Fuel Cell System...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

2: Fuel Cell System Cost - 2013 DOE Fuel Cell Technologies Office Record 14012: Fuel Cell System Cost - 2013 This program record from the U.S. Department of Energy's Fuel Cell...

355

Please send suggestions for improvement to John Webster, webster@engr.wisc.edu, 608-263-1574 9.12 BONES AND JOINTS  

E-Print Network [OSTI]

, like a chunk of rubber, and can even be bent into a loop. When collagen is removed from the bone by calcium varies rapidly with energy in this range of energies; the relatively large beam contains much

Lakes, Roderic

356

FUEL CELLS – MOLTEN CARBONATE FUEL CELLS | Overview  

Science Journals Connector (OSTI)

The molten carbonate fuel cell (MCFC) emerged during the twentieth century as one of the key fuel cell types. It uses an electrolyte of alkali metal carbonates, operates typically at 650 °C, and is best suited to hydrocarbon fuels such as natural gas, coal gas, or biogas. The high operating temperature enables such fuels to be fed directly to the MCFC stacks, leading to conversion efficiencies greater than 50%. Molten carbonate fuel cell systems are ideally suited to applications that need continuous base load power. The first commercial systems, at the 300 kW scale, are therefore being used in applications such as hospitals and hotels.

A.L. Dicks

2009-01-01T23:59:59.000Z

357

Fuel Cell Buses | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Fuel Cell Buses Fuel Cell Buses Download presentation slides from the DOE Fuel Cell Technologies Office webinar "Fuel Cell Buses" held on September 12, 2013. Fuel Cell Buses...

358

Fuel Cells Fact Sheet | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Cells Fact Sheet Fuel Cells Fact Sheet Fact sheet produced by the Fuel Cell Technologies Office describing hydrogen fuel cell technology. Fuel Cells More Documents & Publications...

359

Fuel Cells Team  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Judith Valerio at one of our 31 single-cell test stands Fuel Cell Team The FC team focus is R&D on polymer electrolyte membrane (PEM) fuel cells for commercial and military applications. Our program has had ongoing funding in the area of polymer electrolyte fuel cells since 1977 and has been responsible for enabling breakthroughs in the areas of thin film electrodes and air bleed for CO tolerance. For more information on the history of fuel cell research at Los Alamos, please click here. Fuel cells are an important enabling technology for the Hydrogen Economy and have the potential to revolutionize the way we power the nation and the world. The FC team is exploring the potential of fuel cells as energy-efficient, clean, and fuel-flexible alternatives that will

360

Webinar: Fuel Cell Mobile Lighting  

Broader source: Energy.gov [DOE]

Video recording of the Fuel Cell Technologies Office webinar, Fuel Cell Mobile Lighting, originally presented on November 13, 2012.

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Joint Fuel Cell Bus Joint Fuel Cell Bus Workshop to someone by E-mail Share Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on Facebook Tweet about Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on Twitter Bookmark Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on Google Bookmark Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on Delicious Rank Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on Digg Find More places to share Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings Annual Merit Review Proceedings Workshop & Meeting Proceedings Webinars

362

Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Flow Cells for Energy Flow Cells for Energy Storage Workshop to someone by E-mail Share Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on Facebook Tweet about Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on Twitter Bookmark Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on Google Bookmark Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on Delicious Rank Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on Digg Find More places to share Fuel Cell Technologies Office: Flow Cells for Energy Storage Workshop on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings Annual Merit Review Proceedings

363

Fuel Cell Technologies Office: Early Market Applications for Fuel Cell  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Market Transformation Market Transformation Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies to someone by E-mail Share Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Facebook Tweet about Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Twitter Bookmark Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Google Bookmark Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Delicious Rank Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Digg Find More places to share Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on AddThis.com...

364

Fuel Cells publications  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Materials Science » Materials Science » Fuel Cells » Fuel Cells Publications Fuel Cells publications Research into alternative forms of energy, especially energy security, is one of the major national security imperatives of this century. Get Expertise Melissa Fox Applied Energy Email Catherine Padro Sensors & Electorchemical Devices Email Fernando Garzon Sensors & Electorchemical Devices Email Piotr Zelenay Sensors & Electorchemical Devices Email Rod Borup Sensors & Electorchemical Devices Email Karen E. Kippen Chemistry Communications Email Like a battery, a fuel cell consists of two electrodes separated by an electrolyte-in polymer electrolyte fuel cells, the separator is made of a thin polymeric membrane. Unlike a battery, a fuel cell does not need recharging-it continues to produce electricity as long as fuel flows

365

Fuel Cells Overview  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hydrogen Storage DELIVERY FUEL CELLS STORAGE PRODUCTION TECHNOLOGY VALIDATION CODES & STANDARDS SYSTEMS INTEGRATION / ANALYSES SAFETY EDUCATION RESEARCH & DEVELOPMENT Economy Pat Davis 2 Fuel Cells Technical Goals & Objectives Goal : Develop and demonstrate fuel cell power system technologies for transportation, stationary, and portable applications. 3 Fuel Cells Technical Goals & Objectives Objectives * Develop a 60% efficient, durable, direct hydrogen fuel cell power system for transportation at a cost of $45/kW (including hydrogen storage) by 2010. * Develop a 45% efficient reformer-based fuel cell power system for transportation operating on clean hydrocarbon or alcohol based fuel that meets emissions standards, a start-up time of 30 seconds, and a projected manufactured cost of $45/kW by

366

Distributed Energy Fuel Cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Energy Fuel Cells Energy Fuel Cells DOE Hydrogen DOE Hydrogen and and Fuel Cells Fuel Cells Coordination Meeting Fuel Cell Coordination Meeting June 2-3, 2003 Electricity Users Kathi Epping Kathi Epping Objectives & Barriers Distributed Energy OBJECTIVES * Develop a distributed generation PEM fuel cell system operating on natural gas or propane that achieves 40% electrical efficiency and 40,000 hours durability at $400-750/kW by 2010. BARRIERS * Durability * Heat Utilization * Power Electronics * Start-Up Time Targets and Status Integrated Stationary PEMFC Power Systems Operating on Natural Gas or Propane Containing 6 ppm Sulfur 40,000 30,000 15,000 Hours Durability 750 1,250 2,500 $/kWe Cost 40 32 30 % Electrical Efficiency Large (50-250 kW) Systems 40,000 30,000 >6,000 Hours Durability 1,000 1,500 3,000

367

How Fuel Cells Work  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

How Fuel Cells Work How Fuel Cells Work Diagram: How a PEM fuel cell works. 1. Hydrogen fuel is channeled through field flow plates to the anode on one side of the fuel cell, while oxygen from the air is channeled to the cathode on the other side of the cell. 2. At the anode, a platinum catalyst causes the hydrogen to split into positive hydrogen ions (protons) and negatively charged electrons. 3. The Polymer Electrolyte Membrane (PEM) allows only the positively charged ions to pass through it to the cathode. The negatively charged electrons must travel along an external circuit to the cathode, creating an electrical current. 4. At the cathode, the electrons and positively charged hydrogen ions combine with oxygen to form water, which flows out of the cell.

368

Fuel cell generating plant  

SciTech Connect (OSTI)

This paper discusses a fuel cell generating plant. It comprises a compressed fuel supply; a fuel cell system including fuel conditioning apparatus and fuel cells; a main fuel conduit for conveying fuel from the fuel supply to the fuel cell system; a turbo compressor having a turbine receiving exhaust products from the fuel cell system and a compressor for compressing air; a main air conduit for conveying air from the compressor to the fuel cell system; an auxiliary burner having a primary burner and a pilot; an auxiliary air conduit for conveying air from the compressed fuel supply to the auxiliary burner; an auxiliary exhaust conduit for conveying exhaust products from the auxiliary burner to the turbine; a check valve located between the fuel supply and the pilot; and a gas accumulator in the auxiliary fuel conduit located between the check valve and the pilot.

Sanderson, R.A.

1990-11-27T23:59:59.000Z

369

Concentrator silicon cell research  

SciTech Connect (OSTI)

This project continued the developments of high-efficiency silicon concentrator solar cells with the goal of achieving a cell efficiency in the 26 to 27 percent range at a concentration level of 150 suns of greater. The target efficiency was achieved with the new PERL (passivated emitter, rear locally diffused) cell structure, but only at low concentration levels around 20 suns. The PERL structure combines oxide passivation of both top and rear surfaces of the cells with small area contact to heavily doped regions on the top and rear surfaces. Efficiency in the 22 to 23 percent range was also demonstrated for large-area concentrator cells fabricated with the buried contact solar cell processing sequence, either when combined with prismatic covers or with other innovative approaches to reduce top contact shadowing. 19 refs.

Green, M.A.; Wenham, S.R.; Zhang, F.; Zhao, J.; Wang, A. [New South Wales Univ., Kensington (Australia). Solar Photovoltaic Lab.

1992-04-01T23:59:59.000Z

370

FUEL CELLS – SOLID OXIDE FUEL CELLS | Systems  

Science Journals Connector (OSTI)

In this article, some basic arrangements of solid oxide fuel cell (SOFC) systems are described, starting with atmospheric systems using a catalytic burner or a thermal burner and anode gas recycling. For illustrating the potential electrical efficiency of SOFC systems, their combination with a gas turbine and also with a steam turbine (ST) are described. To be able to evaluate the potential of the different systems, first the essential efficiencies relevant to fuel cell systems are defined and then the basics of calculating energy balance are illustrated. Equations are given to describe, for example, the effect of fuel recycling on system fuel utilization and of internal reforming on the necessary air flow for cooling the stack. It is obvious that electrical efficiency depends strongly on cell voltage and fuel utilization. In the case of cells that operate with a high fuel utilization at cell voltages of 800 mV, a net electrical efficiency above 55% can be achieved. The combination in a pressurized system with a gas turbine enables efficiencies of up to 70% and combining this system with an additional ST allows efficiencies of up to 75%. However, an investigation into the size of these \\{STs\\} shows that such combined systems make sense only above a gas input of 10 MW.

L. Blum; E. Riensche

2009-01-01T23:59:59.000Z

371

Cascade Organic Solar Cells  

Science Journals Connector (OSTI)

Cascade Organic Solar Cells ... Multiple factors control the efficiency of organic solar cells, making it difficult to use single donor or acceptor materials to balance the, often opposing, material properties required to optimize device performance. ... We demonstrate planar organic solar cells consisting of a series of complementary donor materials with cascading exciton energies, incorporated in the following structure: glass/indium-tin-oxide/donor cascade/C60/bathocuproine/Al. ...

Cody W. Schlenker; Vincent S. Barlier; Stephanie W. Chin; Matthew T. Whited; R. Eric McAnally; Stephen R. Forrest; Mark E. Thompson

2011-09-02T23:59:59.000Z

372

Heterojunction solar cell  

DOE Patents [OSTI]

A high-efficiency single heterojunction solar cell is described wherein a thin emitter layer (preferably Ga[sub 0.52]In[sub 0.48]P) forms a heterojunction with a GaAs absorber layer. The conversion efficiency of the solar cell is at least 25.7%. The solar cell preferably includes a passivating layer between the substrate and the absorber layer. An anti-reflection coating is preferably disposed over the emitter layer. 1 fig.

Olson, J.M.

1994-08-30T23:59:59.000Z

373

Molten salt lithium cells  

DOE Patents [OSTI]

Lithium-based cells are promising for applications such as electric vehicles and load-leveling for power plants since lithium is very electropositive and light weight. One type of lithium-based cell utilizes a molten salt electrolyte and is operated in the temperature range of about 400 to 500/sup 0/C. Such high temperature operation accelerates corrosion problems and a substantial amount of energy is lost through heat transfer. The present invention provides an electrochemical cell which may be operated at temperatures between about 100 to 170/sup 0/C. The cell is comprised of an electrolyte, which preferably includes lithium nitrate, and a lithium or lithium alloy electrode.

Raistrick, I.D.; Poris, J.; Huggins, R.A.

1980-07-18T23:59:59.000Z

374

Molten salt lithium cells  

DOE Patents [OSTI]

Lithium-based cells are promising for applications such as electric vehicles and load-leveling for power plants since lithium is very electropositive and light weight. One type of lithium-based cell utilizes a molten salt electrolyte and is operated in the temperature range of about 400.degree.-500.degree. C. Such high temperature operation accelerates corrosion problems and a substantial amount of energy is lost through heat transfer. The present invention provides an electrochemical cell (10) which may be operated at temperatures between about 100.degree.-170.degree. C. Cell (10) comprises an electrolyte (16), which preferably includes lithium nitrate, and a lithium or lithium alloy electrode (12).

Raistrick, Ian D. (Menlo Park, CA); Poris, Jaime (Portola Valley, CA); Huggins, Robert A. (Stanford, CA)

1982-02-09T23:59:59.000Z

375

Microcomposite Fuel Cell Membranes  

Broader source: Energy.gov [DOE]

Summary of microcomposite fuel cell membrane work presented to the High Temperature Membrane Working Group Meeting, Orlando FL, October 17, 2003

376

Fuel Cell Financing Options  

Broader source: Energy.gov [DOE]

Presented at the Clean Energy States Alliance and U.S. Department of Energy Webinar: Financing Fuel Cell Installations, August 30, 2011.

377

A chlorophyll solar cell  

Science Journals Connector (OSTI)

A simple chlorophyll solar cell has been designed built and tested. A voltage output versus time curve has also been obtained. (AIP)

J. Christopher Ludlow

1982-01-01T23:59:59.000Z

378

Fuel Cell Case Study  

Broader source: Energy.gov [DOE]

Presented at the Clean Energy States Alliance and U.S. Department of Energy Webinar: Fuel Cells for Supermarkets, April 4, 2011.

379

Modelling microscale fuel cells.  

E-Print Network [OSTI]

??The focus of this work is to investigate transport phenomena in recently developed microscale fuel cell designs using computational fluid dynamics (CFD). Two microscale fuel… (more)

Bazylak, Aimy Ming Jii

2009-01-01T23:59:59.000Z

380

Mammalian Cell Culture | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mammalian Cell Culture At EMSL, researchers use the single-molecule fluorescencepatch clamp microscope to combine high-sensitivity fluorescence imaging simultaneously with...

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Fuel Cell Technologies Overview  

Broader source: Energy.gov (indexed) [DOE]

Cells Key Benefits Very High Efficiency Reduced CO 2 Emissions Reduced Oil Use Reduced Air Pollution Fuel Flexibility * 40 - 60% (electrical) * > 70% (electrical, hybrid fuel...

382

Hydrogen Fuel Cells  

Fuel Cell Technologies Publication and Product Library (EERE)

The fuel cell — an energy conversion device that can efficiently capture and use the power of hydrogen — is the key to making it happen.

383

Quantum Junction Solar Cells  

Science Journals Connector (OSTI)

Quantum Junction Solar Cells ... § Department of Electrical and Computer Engineering, University of Toronto, 10 King’s College Road, Toronto, Ontario, M5S 3G4, Canada ...

Jiang Tang; Huan Liu; David Zhitomirsky; Sjoerd Hoogland; Xihua Wang; Melissa Furukawa; Larissa Levina; Edward H. Sargent

2012-08-10T23:59:59.000Z

384

Associations between ambient air pollution and bone turnover markers in 10-year old children: Results from the \\{GINIplus\\} and \\{LISAplus\\} studies  

Science Journals Connector (OSTI)

Abstract Negative associations between bone turnover markers and bone mineral density have been reported. In order to study the association between ambient air pollution and bone turnover markers, as indicators of bone loss, we investigated associations between land-use regression modeled air pollution (NO2, PM2.5 mass, PM2.5 – 10 [coarse particles], PM10 mass and PM2.5 absorbance) and bone turnover markers in 2264 children aged 10 years. Serum osteocalcin and C-terminal telopeptide of type I collagen (CTx), measured by Modular-System (Roche), were the two bone turnover markers considered in this analysis. In total population, NO2, PM2.5 – 10 and PM10 mass exposure were positively and significantly associated with both osteocalcin and CTx. A 2.5 (95% CI: 0.6, 4.4) ng/ml increase in osteocalcin and a 24.0 (95% CI: 6.7, 41.3) ng/L increase in \\{CTx\\} were observed per IQR (6.7 ?g/m3) increase in NO2, independent of socioeconomic status, sex, age, pubertal status, fasting status and total physical activity. The estimated coefficients were 3.0 (95% CI: 0.1, 5.8) for osteocalcin and 32.3 (95% CI: 6.1, 58.5) for \\{CTx\\} with PM2.5 – 10; 3.2 (95% CI: 0.0, 6.4) for osteocalcin and 30.7 (95% CI: 1.7, 59.7) for \\{CTx\\} with PM10. Children living close to a major road (? 350 m) had higher levels of both osteocalcin (1.4 [?1.2, 4.0] ng/ml) and \\{CTx\\} (16.2 [?7.4, 39.8] ng/L). The adverse impact of ambient air pollution on bone turnover rates observed in one of the study areas showed stimulation of more such studies.

Chuang Liu; Elaine Fuertes; Claudia Flexeder; Lorenz C. Hofbauer; Dietrich Berdel; Barbara Hoffmann; Jürgen Kratzsch; Andrea von Berg; Joachim Heinrich

2015-01-01T23:59:59.000Z

385

Fuel Cell Demonstration Program  

SciTech Connect (OSTI)

In an effort to promote clean energy projects and aid in the commercialization of new fuel cell technologies the Long Island Power Authority (LIPA) initiated a Fuel Cell Demonstration Program in 1999 with six month deployments of Proton Exchange Membrane (PEM) non-commercial Beta model systems at partnering sites throughout Long Island. These projects facilitated significant developments in the technology, providing operating experience that allowed the manufacturer to produce fuel cells that were half the size of the Beta units and suitable for outdoor installations. In 2001, LIPA embarked on a large-scale effort to identify and develop measures that could improve the reliability and performance of future fuel cell technologies for electric utility applications and the concept to establish a fuel cell farm (Farm) of 75 units was developed. By the end of October of 2001, 75 Lorax 2.0 fuel cells had been installed at the West Babylon substation on Long Island, making it the first fuel cell demonstration of its kind and size anywhere in the world at the time. Designed to help LIPA study the feasibility of using fuel cells to operate in parallel with LIPA's electric grid system, the Farm operated 120 fuel cells over its lifetime of over 3 years including 3 generations of Plug Power fuel cells (Lorax 2.0, Lorax 3.0, Lorax 4.5). Of these 120 fuel cells, 20 Lorax 3.0 units operated under this Award from June 2002 to September 2004. In parallel with the operation of the Farm, LIPA recruited government and commercial/industrial customers to demonstrate fuel cells as on-site distributed generation. From December 2002 to February 2005, 17 fuel cells were tested and monitored at various customer sites throughout Long Island. The 37 fuel cells operated under this Award produced a total of 712,635 kWh. As fuel cell technology became more mature, performance improvements included a 1% increase in system efficiency. Including equipment, design, fuel, maintenance, installation, and decommissioning the total project budget was approximately $3.7 million.

Gerald Brun

2006-09-15T23:59:59.000Z

386

REVIEW Open Access Cell therapy using tolerogenic dendritic cells in  

E-Print Network [OSTI]

with cell therapy using regulatory cells. In our laboratory, as part of a European project, we plan to testREVIEW Open Access Cell therapy using tolerogenic dendritic cells in transplantation Aurélie Moreau the safety of tolerogenic dendritic cell (TolDC) therapy in kidney transplant patients. In this mini-review

Paris-Sud XI, Université de

387

cell trait? Know your sickle cell trait status.  

E-Print Network [OSTI]

What is sickle cell trait? Know your sickle cell trait status. Engage in a slow and gradual experiencing unusual physical distress. People at high risk for having sickle cell trait are those whose countries. sickle cell trait is not a disease. Sickle cell trait is the inheritance of one gene for sickle

Devoto, Stephen H.

388

E-Print Network 3.0 - autologous blood collection Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

stem Summary: after co-infusion of autologous blood stem cells and cul- ture-expanded marrow mesenchy- mal stem cells... hematopoietic stem cells from solid organs has...

389

Fuel cell generator  

DOE Patents [OSTI]

High temperature solid oxide electrolyte fuel cell generators which allow controlled leakage among plural chambers in a sealed housing. Depleted oxidant and fuel are directly reacted in one chamber to combust remaining fuel and preheat incoming reactants. The cells are preferably electrically arranged in a series-parallel configuration.

Isenberg, Arnold O. (Forest Hills, PA)

1983-01-01T23:59:59.000Z

390

NETL: Fuel Cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuel Cells Fuel Cells Coal and Power Systems Fuel Cells SECA Logo Welcome to NETL's Fuel Cells Webpage. In partnership with private industry, educational institutions and national laboratories, we are leading the research, development, and demonstration of high efficiency, fuel flexible solid oxide fuel cells (SOFCs) and coal-based SOFC power generation systems for stationary market large central power plants under the Solid State Energy Conversion Alliance (SECA). The SECA cost reduction goal is to have SOFC systems capable of being manufactured at $400 per kilowatt by 2010. Concurrently, the scale-up, aggregation, and integration of the technology will progress in parallel leading to prototype validation of megawatt (MW)-class fuel flexible products by 2012 and 2015. The SECA coal-based systems goal is the development of large

391

Fuel Cell Development Status  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Development Status Michael Short Systems Engineering Manager United Technologies Corporation Research Center Hamilton Sundstrand UTC Power UTC Fire & Security Fortune 50 corporation $52.9B in annual sales in 2009 ~60% of Sales are in building technologies Transportation Stationary Fuel Cells Space & Defense * Fuel cell technology leader since 1958 * ~ 550 employees * 768+ Active U.S. patents, more than 300 additional U.S. patents pending * Global leader in efficient, reliable, and sustainable fuel cell solutions UTC Power About Us PureCell ® Model 400 Solution Process Overview Power Conditioner Converts DC power to high-quality AC power 3 Fuel Cell Stack Generates DC power from hydrogen and air 2 Fuel Processor Converts natural gas fuel to hydrogen

392

Fuel Cell 101  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuel Cell 101 Fuel Cell 101 Don Hoffman Don Hoffman Ship Systems & Engineering Research Division March 2011 Distribution Statement A: Approved for public release; distribution is unlimited. Fuel Cell Operation * A Fuel Cell is an electrochemical power source * It supplies electricity by combining hydrogen and oxygen electrochemically without combustion. * It is configured like a battery with anode and cathode. * Unlike a battery, it does not run down or require recharging and will produce electricity and will produce electricity, heat and water as long as fuel is supplied. 2H + + 2e - O 2 + 2H + + 2e - 2H 2 O H 2 Distribution Statement A: Approved for public release; distribution is unlimited. 2 FUEL FUEL CONTROLS Fuel Cell System HEAT & WATER CLEAN CLEAN EXHAUST EXHAUST

393

NREL: Learning - Fuel Cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuel Cells Fuel Cells Fuel cells and their ability to cleanly produce electricity from hydrogen and oxygen are what make hydrogen attractive as a "fuel" for transportation use particularly, but also as a general energy carrier for homes and other uses, and for storing and transporting otherwise intermittent renewable energy. Fuel cells function somewhat like a battery-with external fuel being supplied rather than stored electricity-to generate power by chemical reaction rather than combustion. Hydrogen fuel cells, for instance, feed hydrogen gas into an electrode that contains a catalyst, such as platinum, which helps to break up the hydrogen molecules into positively charged hydrogen ions and negatively charged electrons. The electrons flow from the electrode to a terminal that

394

Cell manipulation in microfluidics  

Science Journals Connector (OSTI)

Recent advances in the lab-on-a-chip field in association with nano/microfluidics have been made for new applications and functionalities to the fields of molecular biology, genetic analysis and proteomics, enabling the expansion of the cell biology field. Specifically, microfluidics has provided promising tools for enhancing cell biological research, since it has the ability to precisely control the cellular environment, to easily mimic heterogeneous cellular environment by multiplexing, and to analyze sub-cellular information by high-contents screening assays at the single-cell level. Various cell manipulation techniques in microfluidics have been developed in accordance with specific objectives and applications. In this review, we examine the latest achievements of cell manipulation techniques in microfluidics by categorizing externally applied forces for manipulation: (i) optical, (ii) magnetic, (iii) electrical, (iv) mechanical and (v) other manipulations. We furthermore focus on history where the manipulation techniques originate and also discuss future perspectives with key examples where available.

Hoyoung Yun; Kisoo Kim; Won Gu Lee

2013-01-01T23:59:59.000Z

395

FORENSIC TECHNIQUES FOR CELL PHONES  

E-Print Network [OSTI]

June 2007 FORENSIC TECHNIQUES FOR CELL PHONES FORENSIC TECHNIQUES FOR CELL PHONES Shirley Radack cell phones are widely used for both personal and professional applications, the technology of cell forensics usually do not cover cell phones, especially those with advanced capabilities. The digital

396

Solid oxide fuel cell generator  

DOE Patents [OSTI]

A solid oxide fuel cell generator has a plenum containing at least two rows of spaced apart, annular, axially elongated fuel cells. An electrical conductor extending between adjacent rows of fuel cells connects the fuel cells of one row in parallel with each other and in series with the fuel cells of the adjacent row. 5 figures.

Di Croce, A.M.; Draper, R.

1993-11-02T23:59:59.000Z

397

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 to someone by E-mail 2 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Archives Subscribe Program Presentations

398

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

August 2013 to someone by E-mail August 2013 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2013 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter

399

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

October 2012 to someone by E-mail October 2012 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: October 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications

400

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

April 2012 to someone by E-mail April 2012 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: April 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Archives

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3 to someone by E-mail 3 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: May 2013 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Archives Subscribe Program Presentations

402

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 to someone by E-mail 2 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: June 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Archives Subscribe

403

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

September/October 2013 to someone by E-mail September/October 2013 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September/October 2013 on AddThis.com... Publications

404

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

August 2012 to someone by E-mail August 2012 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: August 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter

405

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 to someone by E-mail 2 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: March 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Archives Subscribe

406

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3 to someone by E-mail 3 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: February 2013 on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter

407

Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

September 2012 to someone by E-mail September 2012 to someone by E-mail Share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on Facebook Tweet about Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on Twitter Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on Google Bookmark Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on Delicious Rank Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on Digg Find More places to share Fuel Cell Technologies Office: Fuel Cell Technologies Office Newsletter: September 2012 on AddThis.com... Publications Program Publications Technical Publications Educational Publications

408

Advances in the surface modification techniques of bone-related implants for last 10 years  

Science Journals Connector (OSTI)

......calcium phosphate coating, bioceramic coating composed of akermanite (Ca2MgSi2O7) was successfully created on both non-biodegradable...of cells on polymers by pulsed laser deposition of uniform akermanite-glass nanolayer. Acta Biomater 2014;10:3295-306......

Zhi-Ye Qiu; Cen Chen; Xiu-Mei Wang; In-Seop Lee

2014-11-01T23:59:59.000Z

409

Fuel Cell Animation- Fuel Cell Stack (Text Version)  

Broader source: Energy.gov [DOE]

This text version of the fuel cell animation demonstrates how a fuel cell uses hydrogen to produce electricity, with only water and heat as byproducts.

410

NREL: Hydrogen and Fuel Cells Research - Fuel Cell Electric Vehicle...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuel Cell Electric Vehicle Evaluations NREL's technology validation team analyzes hydrogen fuel cell electric vehicles (FCEVs) operating in a real-world setting to identify the...

411

Fuel Cell Animation- Fuel Cell Components (Text Version)  

Broader source: Energy.gov [DOE]

This text version of the fuel cell animation demonstrates how a fuel cell uses hydrogen to produce electricity, with only water and heat as byproducts.

412

DOE Fuel Cell Technologies Office Record 14012: Fuel Cell System...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Fuel Cell Technologies Office Record Record : 14012 Date: June 12, 2014 Title: Fuel Cell System Cost - 2013 Update to: Record 12020 Originator: Jacob Spendelow and Jason...

413

Red blood cell malformations Cell shapes Modeling and simulation of red blood cell light scattering  

E-Print Network [OSTI]

that have a "sickle" appearance (see figure to left). This malformed geometry prevents cells from traveling Red blood cell malformations Cell shapes Modeling and simulation of red blood cell light to various diseases and acute conditions, the shape and composition of erythrocytes (red blood cells

California at Berkeley, University of

414

Corrosion Test Cell For Bipolar Plates  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Corrosion Test Cell For Bipolar Plates Corrosion Test Cell For Bipolar Plates A corrosion test cell for evaluating corrosion resistance in fuel cell bipolar plates is described....

415

Energy 101: Fuel Cells | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Fuel Cells Energy 101: Fuel Cells Addthis Description Learn everything you need to know about fuel cells. Topic Hydrogen & Fuel Cells...

416

Types of Fuel Cells | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Fuel Cells Current Technology Types of Fuel Cells Types of Fuel Cells Fuel cells are classified primarily by the kind of electrolyte they employ. This classification...

417

Fuel Cell Animation | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Fuel Cell Animation Fuel Cell Animation This fuel cell animation demonstrates how a fuel cell uses hydrogen to produce electricity, with only water and heat as byproducts. Hydrogen...

418

Fuel Cell Technologies Office: Publications  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuel Cell Technologies Office HOME ABOUT PROGRAM AREAS INFORMATION RESOURCES FINANCIAL OPPORTUNITIES TECHNOLOGIES MARKET TRANSFORMATION NEWS EVENTS EERE Fuel Cell Technologies...

419

Module 5: Fuel Cell Systems  

Broader source: Energy.gov [DOE]

This course covers the systems required to operate a fuel cell engine, the components and functionality of each fuel cell system

420

Radiative cooling of solar cells  

Science Journals Connector (OSTI)

Standard solar cells heat up under sunlight. The resulting increased temperature of the solar cell has adverse consequences on both its efficiency and its reliability. We introduce a...

Zhu, Linxiao; Raman, Aaswath; Wang, Ken Xingze; Anoma, Marc Abou; Fan, Shanhui

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Batteries and Fuel Cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collage of electric cars, plug, battery research lab Collage of electric cars, plug, battery research lab Batteries and Fuel Cells EETD researchers study the basic science and development of advanced batteries and fuel cells for transportation, electric grid storage, and other stationary applications. This research is aimed at developing more environmentally friendly technologies for generating and storing energy, including better batteries and fuel cells. Li-Ion and Other Advanced Battery Technologies Research conducted here on battery technology is aimed at developing low-cost rechargeable advanced electrochemical batteries for both automotive and stationary applications. The goal of fuel cell research is to provide the technologies for the successful commercialization of polymer-electrolyte and solid oxide fuel

422

Fuel Cell Technologies Overview  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

States Energy Advisory Board (STEAB) States Energy Advisory Board (STEAB) Washington, DC Dr. Sunita Satyapal U.S. Department of Energy Fuel Cell Technologies Program Program Manager 3/14/2012 2 | Fuel Cell Technologies Program Source: US DOE 3/19/2013 eere.energy.gov * Introduction - Technology and Market Overview * DOE Program Overview - Mission & Structure - R&D Progress - Demonstration & Deployments * State Activities - Examples of potential opportunities Outline 3 | Fuel Cell Technologies Program Source: US DOE 3/19/2013 eere.energy.gov Fuel cells - convert chemical energy directly into electrical energy, bypassing inefficiencies associated with thermal energy conversion. Available energy is equal to the Gibbs free energy. Combustion Engines - convert chemical energy into thermal energy and

423

Solar cell array interconnects  

DOE Patents [OSTI]

Electrical interconnects are disclosed for solar cells or other electronic components using a silver-silicone paste or a lead-tin (Pb-Sn) no-clean fluxless solder cream, whereby the high breakage of thin (<6 mil thick) solar cells using conventional solder interconnect is eliminated. The interconnects of this invention employs copper strips which are secured to the solar cells by a silver-silicone conductive paste which can be used at room temperature, or by a Pb-Sn solder cream which eliminates undesired residue on the active surfaces of the solar cells. Electrical testing using the interconnects of this invention has shown that no degradation of the interconnects developed under high current testing, while providing a very low contact resistance value. 4 figs.

Carey, P.G.; Thompson, J.B.; Colella, N.J.; Williams, K.A.

1995-11-14T23:59:59.000Z

424

Microbubble cell actuator  

E-Print Network [OSTI]

The field of microsystems technology is rapidly growing, and expanding its horizons to applications in bioengineering. Currently, there are no cell analysis systems that facilitate the collection of dynamic responses for ...

Braff, Rebecca A. (Rebecca Alice)

1999-01-01T23:59:59.000Z

425

Organic solar cell optimizations  

Science Journals Connector (OSTI)

This paper presents recent experimental and theoretical approaches for optimizing organic solar cell efficiencies in both space and energy/time...D/A...) blend film, a corresponding –DBAB- block copolymer film ex...

S. Sun; Z. Fan; Y. Wang; J. Haliburton

2005-03-01T23:59:59.000Z

426

Thin film photovoltaic cells  

DOE Patents [OSTI]

A solar cell has as its transparent electrical contact a grid made from a non-noble metal by providing a layer of copper oxide between the transparent electrical contact and the absorber-generator.

Rothwarf, Allen (Philadelphia, PA)

1981-01-01T23:59:59.000Z

427

Solid Oxide Fuel Cells  

Science Journals Connector (OSTI)

A Solid Oxide Fuel Cell (SOFC) is typically composed of two porous electrodes, interposed between an electrolyte made of a particular solid oxide ceramic material. The system originates from the work of Nernst...

Nigel M. Sammes; Roberto Bove; Jakub Pusz

2006-01-01T23:59:59.000Z

428

Photovoltaic solar cell  

DOE Patents [OSTI]

A photovoltaic solar cell for generating electricity from sunlight is disclosed. The photovoltaic solar cell comprises a plurality of spaced-apart point contact junctions formed in a semiconductor body to receive the sunlight and generate the electicity therefrom, the plurality of spaced-apart point contact junctions having a first plurality of regions having a first doping type and a second plurality of regions having a second doping type. In addition, the photovoltaic solar cell comprises a first electrical contact electrically connected to each of the first plurality of regions and a second electrical contact electrically connected to each of the second plurality of regions, as well as a passivation layer covering major surfaces and sidewalls of the photovoltaic solar cell.

Nielson, Gregory N; Okandan, Murat; Cruz-Campa, Jose Luis; Resnick, Paul J

2013-11-26T23:59:59.000Z

429

Photovoltaic solar cell  

DOE Patents [OSTI]

A photovoltaic solar cell for generating electricity from sunlight is disclosed. The photovoltaic solar cell comprises a plurality of spaced-apart point contact junctions formed in a semiconductor body to receive the sunlight and generate the electricity therefrom, the plurality of spaced-apart point contact junctions having a first plurality of regions having a first doping type and a second plurality of regions having a second doping type. In addition, the photovoltaic solar cell comprises a first electrical contact electrically connected to each of the first plurality of regions and a second electrical contact electrically connected to each of the second plurality of regions, as well as a passivation layer covering major surfaces and sidewalls of the photovoltaic solar cell.

Nielson, Gregory N; Cruz-Campa, Jose Luis; Okandan, Murat; Resnick, Paul J

2014-05-20T23:59:59.000Z

430

ToF-SIMS evaluation of calcium-containing silica/?-PGA hybrid systems for bone regeneration  

Science Journals Connector (OSTI)

Abstract Inorganic/organic hybrids have great potential for the production of bioactive scaffolds which have tailored mechanical properties and degradation rates suitable for tissue engineering. For bone regeneration, calcium incorporation into hybrids at low temperatures is important due to its ability to stimulate new bone formation. As a consequence, understanding the homogeneity of the critical inorganic and organic components will be the key to the development of such hybrids. The aim of this interdisciplinary study was to use time-of-flight secondary ion mass spectrometry (ToF-SIMS) to determine the homogeneity of these critical components. We evaluated various sol–gel silica/?-polyglutamic acid (?-PGA) hybrid systems produced using different routes to introduce the calcium, thereby tailoring and optimizing hybrid syntheses and processing routes. Dimethyl carbonate (DMC) was used to improve the inorganic/organic coupling and its influence on the homogeneity of the hybrid structures was also examined. The results revealed that the calcium salt form of ?-PGA was promising for calcium incorporation since homogeneous products could be obtained. The ToF-SIMS data also indicated that the reaction time of hybrid synthesis and the timing of the addition of DMC can affect the homogeneity of hybrids.

Daming Wang; Jin Nakamura; Gowsihan Poologasundarampillai; Toshihiro Kasuga; Julian R. Jones; David S. McPhail

2014-01-01T23:59:59.000Z

431

Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium  

E-Print Network [OSTI]

†, [8,9] Carrie Nielson, [10] Priya Srikanth, [10] Sylvie Giroux, [11] Scott G Wilson, [2,12,13] Hou-Feng Zheng, [14] Albert V Smith, [15,16] Stephen R Pye, [17] Paul J Leo, [18] Alexander Teumer, [19] Joo-Yeon Hwang, [20] Claes Ohlsson, [21] Fiona Mc... Email: stephen@srl.cam.ac.uk Tel : +44 1223 748668 Fax: +44 1223 748658 5   ABSTRACT Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by x...

Moayyeri, Alireza; Hsu, Yi-Hsiang; Karasik, David; Estrada, Karol; Xiao, Su-Mei; Nielson, Carrie; Srikanth, Priya; Giroux, Sylvie; Wilson, Scott G.; Zheng, Hou-Feng; Smith, Albert V.; Pye, Stephen R.; Leo, Paul J.; Teumer, Alexander; Hwang, Joo-Yeon; Ohlsson, Claes; McGuigan, Fiona; Minster, Ryan L.; Hayward, Caroline; Olmos, José M.; Lyytikäinen, Leo-Pekka; Lewis, Joshua R.; Swart, Karin M. A.; Masi, Laura; Oldmeadow, Chris; Holliday, Elizabeth G.; Cheng, Sulin; van Schoor, Natasja M.; Harvey, Nicholas C.; Kruk, Marcin; Del Greco M, Fabiola; Igl, Wilmar; Trummer, Olivia; Grigoriou, Efi; Luben, Robert; Liu, Ching-Ti; Zhou, Yanhua; Oei, Ling; Medina-Gomez, Carolina; Zmuda, Joseph; Tranah, Greg; Brown, Suzanne J.; Williams, Frances M.; Soranzo, Nicole; Jakobsdottir, Johanna; Siggeirsdottir, Kristin; Holliday, Kate L.; Hannemann, Anke; Go, Min Jin; Garcia, Melissa; Polasek, Ozren; Laaksonen, Marika; Zhu, Kun; Enneman, Anke W.; McEvoy, Mark; Peel, Roseanne; Sham, Pak Chung; Jaworski, Maciej; Johansson, Åsa; Hicks, Andrew A.; Pludowski, Pawel; Scott, Rodney; Dhonukshe-Rutten, Rosalie A. M.; van der Velde, Nathalie; Kähönen, Mika; Viikari, Jorma S.; Sievänen, Harri; Raitakari, Olli T.; González-Macías, Jesús; Hernández, Jose L.; Mellström, Dan; Ljunggren, Östen; Cho, Yoon Shin; Völker, Uwe; Nauck, Matthias; Homuth, Georg; Völzke, Henry; Haring, Robin; Brown, Matthew A.; McCloskey, Eugene; Nicholson, Geoffrey C.; Eastell, Richard; Eisman, John A.; Jones, Graeme; Reid, Ian R.; Dennison, Elaine M.; Wark, John; Boonen, Steven; Vanderschueren, Dirk; Wu, Frederick C. W.; Aspelund, Thor; Richards, J. Brent; Bauer, Doug; Hofman, Albert; Khaw, Kay-Tee; Dedoussis, George; Obermayer-Pietsch, Barbara; Gyllensten, Ulf; Pramstaller, Peter P.; Lorenc, Roman S.; Cooper, Cyrus; Kung, Annie Wai Chee; Lips, Paul; Alen, Markku; Attia, John; Brandi, Maria Luisa; de Groot, Lisette C. P. G. M.; Lehtimäki, Terho; Riancho, José A.; Campbell, Harry; Liu, Yongmei; Harris, Tamara B.; Akesson, Kristina; Karlsson, Magnus; Lee, Jong-Young; Wallaschofski, Henri; Duncan, Emma L.; O'Neill, Terence W.; Gudnason, Vilmundur; Spector, Timothy D.; Rousseau, François; Orwoll, Eric; Cummings, Steve; Wareham, Nick J.; Rivadeneira, Fernando; Uitterlinden, Andre G.; Prince, Richard L.; Kiel, Douglas P.; Reeve, Jonathan; Kaptoge, Stephen K.

2014-01-14T23:59:59.000Z

432

Thin silicon solar cells  

SciTech Connect (OSTI)

The silicon-film design achieves high performance by using a dun silicon layer and incorporating light trapping. Optimally designed thin crystalline solar cells (<50 microns thick) have performance advantages over conventional thick devices. The high-performance silicon-film design employs a metallurgical barrier between the low-cost substrate and the thin silicon layer. Light trapping properties of silicon-film on ceramic solar cells are presented and analyzed. Recent advances in process development are described here.

Hall, R.B.; Bacon, C.; DiReda, V.; Ford, D.H.; Ingram, A.E.; Cotter, J.; Hughes-Lampros, T.; Rand, J.A.; Ruffins, T.R.; Barnett, A.M. [Astro Power Inc., Solar Park, Newark, DE (United States)

1992-12-01T23:59:59.000Z

433

Compliant fuel cell system  

DOE Patents [OSTI]

A fuel cell assembly comprising at least one metallic component, at least one ceramic component and a structure disposed between the metallic component and the ceramic component. The structure is configured to have a lower stiffness compared to at least one of the metallic component and the ceramic component, to accommodate a difference in strain between the metallic component and the ceramic component of the fuel cell assembly.

Bourgeois, Richard Scott (Albany, NY); Gudlavalleti, Sauri (Albany, NY)

2009-12-15T23:59:59.000Z

434

Monolithic tandem solar cell  

SciTech Connect (OSTI)

It is an object of the invention to provide a monolithic tandem photovoltaic solar cell which is highly radiation resistant and efficient; in which the energy bandgap of the lower subcell can be tailored for specific applications; solar cell comprising layers of InP and GaInAsP (or GaInAs), where said photovoltaic cell is useful, for example, in space power applications; having an improved power-to-mass ratio; in which subcells are lattice-matches; and are both two terminal and three terminal monolithic tandem photovoltaic solar cells. To achieve the foregoing and other objects and in accordance with the purpose of the present invention, as embodied and broadly described herein, the monolithic tandem photovoltaic solar cell may comprise; (a) an InP substrate having an upper surface; (b) a first photoactive subcell on the upper surface of the InP substrate; wherein the first subcell comprises GaInAs (which could include GaInAsP) and includes a homojunction; and (c) a second photoactive subcell on the first subcell; wherein the second subcell comprises InP and includes a homojunction. The cell is described in detail. 5 figs., 2 tabs.

Wanlass, M.W.

1989-11-03T23:59:59.000Z

435

E-CELL: software environment for whole-cell simulation  

Science Journals Connector (OSTI)

......protein synthesis. The cell would become unable...due to spontaneous degradation. Figure 5 is a trace...ATP in the starving cell. Glucose in the...shortage of glucose to fuel glycolysis arrests...mRNA, in which the cell was starved at 1000...transcription and degradation. When the cell runs......

M Tomita; K Hashimoto; K Takahashi; TS Shimizu; Y Matsuzaki; F Miyoshi; K Saito; S Tanida; K Yugi; JC Venter; CA Hutchison; 3rd

1999-01-01T23:59:59.000Z

436

Cell Component Accelerated Stress Test Protocols for PEM Fuel Cells  

Broader source: Energy.gov [DOE]

Accelerated Stress Test Protocols for PEM Fuel Cells, Electrocatalysts, Supports, Membranes, and Membrane Electrode Assemblies

437

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration  

Science Journals Connector (OSTI)

...vascularization and cell penetration. The scaffolds...and degradation rates. However, a full...100mum to allow cell penetration and blood vessels...resorbs at the same rate as that at which...vascularization and cell penetration. The scaffolds...and degradation rates. However, a full...

2012-01-01T23:59:59.000Z

438

``In-bone'' Utricle CulturesVA Simplified, Atraumatic Technique for In Situ Cultures of the Adult Mouse  

E-Print Network [OSTI]

effectively in stud- ies of hair cell regeneration and hair cell death, as well as various agents that protect and protection. Background: The current in vitro technique for studying hair cells of the mature mouse utricle to the protective drug tacrine resulted in sig- nificant protection against neomycin (p G 0.05, 3-way analysis

Rubel, Edwin

439

Single Cell Motion in Aggregates of Embryonic Cells  

Science Journals Connector (OSTI)

We investigate the motion of individual pigmented retinal cells in aggregates of neural retinal cells obtained from chicken embryos. Individual cells in aggregates move randomly in the absence of chemical or adhesion gradients: the power spectrum of position and velocity versus time correspond to Brownian motion and the velocities are uncorrelated in time. Thus a quasithermal model of cell migration like the extended Potts model is appropriate. We also measure cell diffusivity and the cell velocity distribution. The results support the idea that collections of embryonic cells behave as liquids with membrane fluctuations playing the role of temperature.

José C. M. Mombach and James A. Glazier

1996-04-15T23:59:59.000Z

440

NANOCOMPOSITE ENABLED SENSITIZED SOLAR CELL  

E-Print Network [OSTI]

solar cell The history of dye sensitization dates back to the photosensitization phenomenon by organic

Phuyal, Dibya

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

An advanced fuel cell simulator  

E-Print Network [OSTI]

of Fuel Cells ...................... 4 D. Fuel Cell Power Plant ..................... 4 E. Challenges in Fuel Cell Development ............ 5 F. Previous Work ......................... 6 G. Solar Array Simulators .................... 8 H. Battery... ............................. 54 28 Under-voltage Fault ........................... 55 1 CHAPTER I INTRODUCTION The depleting fossil fuel resources and increasing pollution are leading to the research and development of alternate energy generation techniques like fuel cells...

Acharya, Prabha Ramchandra

2005-11-01T23:59:59.000Z

442

Hydrogen & Fuel Cells Program Overview  

E-Print Network [OSTI]

Hydrogen & Fuel Cells Program Overview Dr. Sunita Satyapal Program Manager Hydrogen and Fuel Cells Program U.S. Department of Energy Hydrogen + Fuel Cells 2011 International Conference and Exhibition Vancouver, Canada May 17, 2011 #12;Enable widespread commercialization of hydrogen and fuel cell

443

Breakthrough Vehicle Development - Fuel Cells  

Fuel Cell Technologies Publication and Product Library (EERE)

Document describing research and development program for fuel cell power systems for transportation applications.

444

Fuel Cell Technologies Office: Glossary  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Glossary to someone by Glossary to someone by E-mail Share Fuel Cell Technologies Office: Glossary on Facebook Tweet about Fuel Cell Technologies Office: Glossary on Twitter Bookmark Fuel Cell Technologies Office: Glossary on Google Bookmark Fuel Cell Technologies Office: Glossary on Delicious Rank Fuel Cell Technologies Office: Glossary on Digg Find More places to share Fuel Cell Technologies Office: Glossary on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings Webinars Data Records Databases Glossary Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells Technology Validation Manufacturing Codes & Standards Education Systems Analysis Contacts Glossary

445

Fuel Cell Technologies Office: Presentations  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Presentations to Presentations to someone by E-mail Share Fuel Cell Technologies Office: Presentations on Facebook Tweet about Fuel Cell Technologies Office: Presentations on Twitter Bookmark Fuel Cell Technologies Office: Presentations on Google Bookmark Fuel Cell Technologies Office: Presentations on Delicious Rank Fuel Cell Technologies Office: Presentations on Digg Find More places to share Fuel Cell Technologies Office: Presentations on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings Annual Merit Review Proceedings Workshop & Meeting Proceedings Webinars Data Records Databases Glossary Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells

446

The Activation of MEK/ERK Signaling Pathway by Bone Morphogenetic Protein 4 to Increase Hepatocellular Carcinoma Cell Proliferation and Migration  

Science Journals Connector (OSTI)

...Research, Kaohsiung Medical University Hospital...housed under controlled lighting (14 hours of light...pathologists at Kaohsiung Medical University Hospital...University-Kaohsiung Medical University Joint Research Center. The costs of publication of this...

Chiang-Yen Chiu; Kung-Kai Kuo; Tzu-Lei Kuo; King-The Lee; and Kuang-Hung Cheng

2012-03-01T23:59:59.000Z

447

Fuel Cells at NASCAR | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Cells at NASCAR Fuel Cells at NASCAR Download presentation slides from the DOE Fuel Cell Technologies Office webinar "Fuel Cells at NASCAR" held on April 17, 2014. Fuel Cells at...

448

Theoretical study of the competition between cell-cell and cell-matrix adhesions  

Science Journals Connector (OSTI)

Adhesions between neighboring cells or between cells and their surrounding tissue/matrix play a crucial role in a wide range of biological processes. In order to investigate the competitive mechanisms between cell-cell and cell-matrix adhesions, we here develop a theoretical framework for multiple interacting cells lying on a planar matrix coated with distributed ligands. This model allows us to study, from the viewpoints of energy and statistics, the effects of such physical mechanisms as binding energy of bonds, nonspecific interactions, elastic deformation of cell membranes, and mixing entropy. Our calculations show that cell-matrix adhesion cannot occur when the ligand density on the matrix is lower than a threshold value, and cell-cell adhesion does not happen for a high ligand density. Glycocalyx repulsion plays a more important role in cell-matrix adhesion than in cell-cell adhesion. In addition, it is found that the cell-cell adhesion density decreases as the number of cells increases.

Guang-Kui Xu; Xi-Qiao Feng; Hong-Ping Zhao; Bo Li

2009-07-27T23:59:59.000Z

449

Reservoir Character of the Avalon Shale (Bone Spring Formation) of the Delaware Basin, West Texas and Southeast New Mexico: Effect of Carbonate-rich Sediment Gravity Flows  

E-Print Network [OSTI]

play is not considered to extend to the top of the first Bone Spring carbonate because hydraulic fracturing in the upper parts may penetrate overlying water-bearing units within the Delaware Mountains Group. The Avalon has been reported to range from...

Stolz, Dustin

2014-05-31T23:59:59.000Z

450

Changes in Bone Mineral, Lean Body Mass and Fat Content as Measured by Dual Energy X-ray Absorptiometry: A Longitudinal Study  

Science Journals Connector (OSTI)

Bone mineral density (BMD) and soft tissue composition were measured by dual energy X-ray absorptiometry (DXA) 3–4 years apart in 273 men and women aged 23–90. We found different rates of BMD loss in differen...

M. K. Karlsson; K. J. Obrant; B. E. Nilsson; O. Johnell

2000-02-01T23:59:59.000Z

451

Efficacy of rhBMP-2 loaded PCL/PLGA/?-TCP guided bone regeneration membrane fabricated by 3D printing technology for reconstruction of calvaria defects in rabbit  

Science Journals Connector (OSTI)

We successfully fabricated a three-dimensional (3D) printing-based PCL/PLGA/?-TCP guided bone regeneration (GBR) membrane that slowly released rhBMP-2. To impregnate the GBR membrane with intact rhBMP-2, collagen solution encapsulating rhBMP-2 (5?µg?ml?1) was infused into pores of a PCL/PLGA/?-TCP membrane constructed using a 3D printing system with four dispensing heads. In a release profile test, sustained release of rhBMP-2 was observed for up to 28?d. To investigate the efficacy of the GBR membrane on bone regeneration, PCL/PLGA/?-TCP membranes with or without rhBMP-2 were implanted in an 8?mm calvaria defect of rabbits. Bone formation was evaluated at weeks 4 and 8 histologically and histomorphometrically. A space making ability of the GBR membrane was successfully maintained in both groups, and significantly more new bone was formed at post-implantation weeks 4 and 8 by rhBMP-2 loaded GBR membranes. Interestingly, implantation with rhBMP-2 loaded GBR membranes led to almost entire healing of calvaria defects within 8?weeks.

Jin-Hyung Shim; Min-Chul Yoon; Chang-Mo Jeong; Jinah Jang; Sung-In Jeong; Dong-Woo Cho; Jung-Bo Huh

2014-01-01T23:59:59.000Z

452

Cell Phone Detection Techniques  

SciTech Connect (OSTI)

A team composed of Rick Pratt, Dave Puczyki, Kyle Bunch, Ryan Slaugh, Morris Good, and Doug McMakin teamed together to attempt to exploit cellular telephone features and detect if a person was carrying a cellular telephone into a Limited Area. The cell phone’s electromagnetic properties were measured, analyzed, and tested in over 10 different ways to determine if an exploitable signature exists. The method that appears to have the most potential for success without adding an external tag is to measure the RF spectrum, not in the cell phone band, but between 240 and 400MHz. Figures 1- 7 show the detected signal levels from cell phones from three different manufacturers.

Pratt, Richard M.; Bunch, Kyle J.; Puzycki, David J.; Slaugh, Ryan W.; Good, Morris S.; McMakin, Douglas L.

2007-10-01T23:59:59.000Z

453

Separators for electrochemical cells  

DOE Patents [OSTI]

Provided are separators for use in an electrochemical cell comprising (a) an inorganic oxide and (b) an organic polymer, wherein the inorganic oxide comprises organic substituents. Preferably, the inorganic oxide comprises an hydrated aluminum oxide of the formula Al.sub.2O.sub.3.xH.sub.2O, wherein x is less than 1.0, and wherein the hydrated aluminum oxide comprises organic substituents, preferably comprising a reaction product of a multifunctional monomer and/or organic carbonate with an aluminum oxide, such as pseudo-boehmite and an aluminum oxide. Also provided are electrochemical cells comprising such separators.

Carlson, Steven Allen; Anakor, Ifenna Kingsley

2014-11-11T23:59:59.000Z

454

Superlattice cascade solar cell  

SciTech Connect (OSTI)

This paper reports progress toward realization of a new cascade solar cell structure whose chief advantages over other present concepts are: use of silicon for the substrate and low bandgap cell; avoidance of the necessity of lattice matching; and incorporation of a GaAs/GaP superlattice to enhance efficiency and provide a low-resistance connecting junction. Details of the design and operation of an OMCVD system for growing this structure are presented. Results of experiments to optimize layer thickness, compositional uniformity, and surface morphology are described.

Wanlass, M.W.; Blakeslee, A.E.

1982-09-01T23:59:59.000Z

455

Monolithic tandem solar cell  

SciTech Connect (OSTI)

This patent describes a single-crystal, monolithic, tandem, photovoltaic solar cell which includes an InP substrate having an upper and lower surfaces, a first photoactive subcell on the upper surface of the InP substrate, and a second photoactive subcell on the first subcell. The first photovoltaic subcell is GaInAsP of defined composition. The second subcell is InP. The two subcells are lattice matched. The solar cell can be provided as a two- terminal device or a three-terminal device.

Wanlass, M.W.

1991-05-28T23:59:59.000Z

456

Cylindrical electric cell  

SciTech Connect (OSTI)

The invention relates to a cylindrical electric cell in which the negative electrode (8) is a sheet of lithium wound round a current collector (1) which is elastically deformable and is in the form of a cylinder whose directrix is a substantially circular curve with two distinct ends. In accordance with the invention, the two portions of cylinder close to said ends are cut into matching shapes so that they fit into each other, the protruding parts (2) of one portion being accomodated in the recessed parts (3) of the other portion. Application to electric cells whose positive active material is liquid.

Gelin, G.

1980-12-02T23:59:59.000Z

457

Solar Cells: Spin-Cast Bulk Heterojunction Solar Cells: A Dynamical...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Solar Cells: Spin-Cast Bulk Heterojunction Solar Cells: A Dynamical Investigation Solar Cells: Spin-Cast Bulk Heterojunction Solar Cells: A Dynamical Investigation Print Wednesday,...

458

Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice  

Science Journals Connector (OSTI)

......Radiation Risk Reduction...units and nuclear power plants. Uncontrolled...potential terrorism incidents...microscopic assessment of bone marrow...genotoxic assessment. Residual...persons at risk would be...radiobiology of nuclear terrorism. Molecular......

Bing Wang; Kaoru Tanaka; Akinori Morita; Yasuharu Ninomiya; Kouichi Maruyama; Kazuko Fujita; Yoshio Hosoi; Mitsuru Nenoi

2013-07-01T23:59:59.000Z

459

Lysolecithin and Cell Fusion  

Science Journals Connector (OSTI)

... INTEREST in the fusion of biological membranes has recently been stimulated by investigations on the biochemistry of secretion1, ... of membranes in the lysosomal vacuolar system2 and, in particular, by work on the fusion of cells that is induced by viruses3'4. For C3ll ...

A. R. POOLE; J. I. HOWELL; J. A. LUCY

1970-08-22T23:59:59.000Z

460

Photo-Electric Cells  

Science Journals Connector (OSTI)

... T.” for the grounds of his “most serious” criticism of our volume on “Photo-electric Cells” reviewed in NATURE of July 19, p. 90. He says that ... reviewed in NATURE of July 19, p. 90. He says that the theory that photo-electrons are the free electrons of the metal is “not one which is generally ...

NORMAN R. CAMPBELL; DOROTHY RITCHIE

1930-08-30T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Thin film photovoltaic cell  

DOE Patents [OSTI]

A thin film photovoltaic cell having a transparent electrical contact and an opaque electrical contact with a pair of semiconductors therebetween includes utilizing one of the electrical contacts as a substrate and wherein the inner surface thereof is modified by microroughening while being macro-planar.

Meakin, John D. (Newark, DE); Bragagnolo, Julio (Newark, DE)

1982-01-01T23:59:59.000Z

462

Solar Cell Simulation  

K-12 Energy Lesson Plans and Activities Web site (EERE)

Students model the flow of energy from the sun as it enters a photovoltaic cell, moves along a wire and powers a load. The game-like atmosphere involves the younger students and helps them understand the continuous nature of the flow of energy. For a related lesson, please see the activity “Solar Powered System” (PDF 430 KB).

463

Introgression & mapping Fiber cell  

E-Print Network [OSTI]

Germplasm Introgression Genomics & mapping Fiber cell initiation Radiation hybrid (RH) mapping and breeding. Research activities commonly include plant breeding, genetics, genomics, cytogenetics, molecular methods. (C, S) · Contribute uniquely to genomics and its relevance to genetic improvement (C,S) · Harness

464

Fuel Cell Technologies Office: Joint Fuel Cell Bus Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuel Cell Bus Workshop Fuel Cell Bus Workshop The U.S. Department of Energy (DOE) and the U.S. Department of Transportation (DOT) held a Fuel Cell Bus Workshop on June 7, 2010 in Washington, D.C. in conjunction with the DOE Hydrogen and Fuel Cell Program Annual Merit Review. The workshop plenary and breakout session brought together technical experts from industry, end users, academia, DOE national laboratories, and other government agencies to address the status and technology needs of fuel cell powered buses. Meeting Summary Joint Fuel Cell Bus Workshop Summary Report Presentations Fuel Cell Bus Workshop Overview & Purpose, Dimitrios Papageorgopoulos, DOE Users Perspective on Advanced Fuel Cell Bus Technology, Nico Bouwkamp, CaFCP and Leslie Eudy, NREL Progress and Challenges for PEM Transit Fleet Applications, Tom Madden, UTC Power, LLC

465

Stationary Fuel Cells: Overview of Hydrogen and Fuel Cell Activities  

Broader source: Energy.gov (indexed) [DOE]

& & Renewable Energy Stationary Fuel Cells: Overview of Hydrogen and Fuel Cell Activities Pete Devlin Fuel Cell Technologies Program United States Department of Energy Federal Utility Partnership Working Group April 14 th , 2010 2 * DOE Fuel Cell Market Transformation Overview * Overview of CHP Concept * Stationary Fuel Cells for CHP Applications * Partnering and Financing (Sam Logan) * Example Project Outline 3 Fuel Cells: Addressing Energy Challenges Energy Efficiency and Resource Diversity  Fuel cells offer a highly efficient way to use diverse fuels and energy sources. Greenhouse Gas Emissions and Air Pollution:  Fuel cells can be powered by emissions-free fuels that are produced from clean, domestic resources. Stationary Power (including CHP & backup power)

466

Diagnostic Studies on Li-Battery Cells and Cell Components  

Broader source: Energy.gov [DOE]

2011 DOE Hydrogen and Fuel Cells Program, and Vehicle Technologies Program Annual Merit Review and Peer Evaluation

467

Diagnostic Studies on Lithium Battery Cells and Cell Components  

Broader source: Energy.gov [DOE]

2012 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

468

Fuel Cell Handbook, Fourth Edition  

SciTech Connect (OSTI)

Robust progress has been made in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in January 1994. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultra high efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 6 describe the four major fuel cell types and their performance based on cell operating conditions. The section on polymer electrolyte membrane fuel cells has been added to reflect their emergence as a significant fuel cell technology. Phosphoric acid, molten carbonate, and solid oxide fuel cell technology description sections have been updated from the previous edition. New information indicates that manufacturers have stayed with proven cell designs, focusing instead on advancing the system surrounding the fuel cell to lower life cycle costs. Section 7, Fuel Cell Systems, has been significantly revised to characterize near-term and next-generation fuel cell power plant systems at a conceptual level of detail. Section 8 provides examples of practical fuel cell system calculations. A list of fuel cell URLs is included in the Appendix. A new index assists the reader in locating specific information quickly.

Stauffer, D.B; Hirschenhofer, J.H.; Klett, M.G.; Engleman, R.R.

1998-11-01T23:59:59.000Z

469

EE580 Solar Cells Todd J. Kaiser  

E-Print Network [OSTI]

7/21/2010 1 EE580 ­ Solar Cells Todd J. Kaiser · Lecture 06 · Solar Cell Materials & Structures 1Montana State University: Solar Cells Lecture 6: Solar Cells Solar Cell Technologies · A) Crystalline Silicon · B) Thin Film · C) Group III-IV Cells 2Montana State University: Solar Cells Lecture 6: Solar

Kaiser, Todd J.

470

Effects of Radiation on Adaptive Immunity: Contact Hypersensitivity Model  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiation on Adaptive Immunity: Contact Hypersensitivity Model Radiation on Adaptive Immunity: Contact Hypersensitivity Model Gregory Nelson Loma Linda University Abstract It has long been appreciated that cells of the immune system are radiosensitive and use apoptosis as the primary mechanism of cell death following injury. The hypervariability of the immunoglobulin superfamily of genes expressed in lymphoid cells also led to the appreciation of the nonhomologous end joining mechanism of DNA repair. Clinically, whole body irradiation is used in treatment of some lymphomas and as an immunosuppressive agent for bone marrow transplants. Inflammation at sites of radiotherapy is a common side effect. Many studies with radiation have addressed the changes in cell populations following radiation exposure and have shown a reproducible pattern of relative sensitivities amongst

471

Hormonally Regulated Programmed Cell Death in Barley Aleurone Cells  

Science Journals Connector (OSTI)

...than for GA-treated cells, and rarely does a single large vacuole fill the cell ( 6 ). Degradation of nuclear DNA is delayed...10 ), and the rate of cell death is considerably...result in an inability to fuel the plasma membrane proton...

Paul C. Bethke; Jennifer E. Lonsdale; Angelika Fath; Russell L. Jones

472

Meteorological Effects on Solar Cells  

Science Journals Connector (OSTI)

30 June 1977 research-article Meteorological Effects on Solar Cells J. R. Mallinson P. T. Landsberg The effect of different meteorological conditions on solar cell outputs has been investigated...

1977-01-01T23:59:59.000Z

473

Acetate metabolism in cancer cells  

E-Print Network [OSTI]

Macromolecule biosynthesis is required to duplicate cell components and support proliferation. Studies examining the nutrients used by cancer cells have focused on the contribution of glucose and glutamine carbon for ...

Hosios, Aaron M

2014-01-01T23:59:59.000Z

474

Fuel Cell Kickoff Meeting Agenda  

Broader source: Energy.gov (indexed) [DOE]

3:40 Aligned Carbon Nanotube-Based MEA and PEMFC D-J Liu, ANL 4:00 Light Weight Low Cost PEM Fuel Cell Stacks J. Wainright, CWRU 4:20 Adaptive Stack with Subdivided Cells for...

475

Air Liquide- Biogas & Fuel Cells  

Broader source: Energy.gov [DOE]

Presentation about Air Liquide's biogas technologies and integration with fuel cells. Presented by Charlie Anderson, Air Liquide, at the NREL/DOE Biogas and Fuel Cells Workshop held June 11-13, 2012, in Golden, Colorado.

476

DOE Hydrogen & Fuel Cell Overview  

Broader source: Energy.gov (indexed) [DOE]

Natural Gas Power Heat + Cooling Electricity Cooling Natural Gas Natural Gas or Biogas Fuel Cell H Excess power generated by the fuel cell is fed to the grid National...

477

Alkaline Membrane Fuel Cell Workshop  

Broader source: Energy.gov [DOE]

A workshop on alkaline membrane fuel cells (AMFC) was held May 8-9, 2011, before the 2011 Hydrogen and Fuel Cells Annual Merit Review, at Crystal Gateway Marriott in Arlington, Virginia.

478

Organic Solar Cells — A Survey  

Science Journals Connector (OSTI)

The objective of this study was to examine in some detail the question of efficient organic solar cells. The scientific-technical situation concerning organic solar cells is highly confusing and unsatisfactory. I...

Dieter Bonnet; Jürgen Volkheimer

1991-01-01T23:59:59.000Z

479

2009 Fuel Cell Market Report  

Fuel Cell Technologies Publication and Product Library (EERE)

Fuel cells are electrochemical devices that combine hydrogen and oxygen to produce electricity, water, and heat. Unlike batteries, fuel cells continuously generate electricity, as long as a source of

480

Fabrication and Characterization of Organic Solar Cells  

E-Print Network [OSTI]

processable polymer photovoltaic cells by self?organization Photodiodes,  and  Photovoltaic  Cells.   Applied Physics F,  Heeger  AJ.   Polymer  Photovoltaic  Cells  ?  Enhanced 

Yengel, Emre

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "bone marrow cells" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Microfluidic Microbial Fuel Cells for Microstructure Interrogations  

E-Print Network [OSTI]

treatment, sedi- ment or marine fuel cells for fieldmicrobial fuel cells demonstrating marine (left) and soil (1]. Sediment and Marine Microbial fuel cells can also

Parra, Erika Andrea

2010-01-01T23:59:59.000Z

482

Fuel Cells News | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Fuel Cells News Fuel Cells News October 16, 2014 Webinar October 21: Opportunities for Wide Bandgap Semiconductor Power Electronics for Hydrogen and Fuel Cell Applications The...

483

Microfluidic Microbial Fuel Cells for Microstructure Interrogations  

E-Print Network [OSTI]

Model of hydrogen fuel cell kinetic losses includingschematic of typical hydrogen fuel cell performancephase factors on hydrogen fuel cell theoretical efficiency,

Parra, Erika Andrea

2010-01-01T23:59:59.000Z

484

Fuel Cell Technologies Office Newsletter Archives | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Information Resources Newsletter Fuel Cell Technologies Office Newsletter Archives Fuel Cell Technologies Office Newsletter Archives View previous issues of the Fuel Cell...

485

Hydrogen & Fuel Cells Program Overview  

Broader source: Energy.gov [DOE]

2011 DOE Hydrogen and Fuel Cells Program, and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Joint Plenary

486

Hydrogen and Fuel Cell Activities  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

electrolysis, using renewable electricity * Conventional fuels - including natural gas, propane, diesel 3 | Fuel Cell Technologies Program Source: US DOE 852011...

487

MORE POLYSILICON FOR SOLAR CELLS  

Science Journals Connector (OSTI)

MORE POLYSILICON FOR SOLAR CELLS ... MANUFACTURING: OCI and Wacker expand raw material capacity in South Korea and U.S. ...

MELODY VOITH

2010-12-20T23:59:59.000Z

488

Fuel Cell Technologies Office: Publications  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Databases Glossary Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells Technology Validation Manufacturing Codes & Standards Education Systems Analysis...

489

Force-Extension Relationship of Cell-Cell Contacts  

Science Journals Connector (OSTI)

Adherens junctions (AJ) are adhesive motifs joining neighboring cells. The physical contacts are fingerlike structures which grow perpendicular to the cell-cell interface. While their length may vary with the applied force, their density is independent of length. Here we measure AJ contact lengths while varying the mean contractile force of the cell using nocodazole. Using this assay and a simple mechanical model, we measure an effective spring constant of about 30??pN/?m per finger. This measurement may enable the estimation of cell monolayer force distributions from a simple AJ image.

Julien Brevier; Marcel Vallade; Daniel Riveline

2007-06-28T23:59:59.000Z

490

Method for fabricating silicon cells  

DOE Patents [OSTI]

A process is described for making high-efficiency solar cells. This is accomplished by forming a diffusion junction and a passivating oxide layer in a single high-temperature process step. The invention includes the class of solar cells made using this process, including high-efficiency solar cells made using Czochralski-grown silicon. 9 figs.

Ruby, D.S.; Basore, P.A.; Schubert, W.K.

1998-08-11T23:59:59.000Z

491

Meteorological Effects on Solar Cells  

Science Journals Connector (OSTI)

...research-article Meteorological Effects on Solar Cells J. R. Mallinson P. T. Landsberg...different meteorological conditions on solar cell outputs has been investigated, using a model for a solar cell (p-on-n or n-on-p) which...

1977-01-01T23:59:59.000Z

492

Fuel cell generator energy dissipator  

DOE Patents [OSTI]

An apparatus and method are disclosed for eliminating the chemical energy of fuel remaining in a fuel cell generator when the electrical power output of the fuel cell generator is terminated. During a generator shut down condition, electrically resistive elements are automatically connected across the fuel cell generator terminals in order to draw current, thereby depleting the fuel

Veyo, Stephen Emery (Murrysville, PA); Dederer, Jeffrey Todd (Valencia, PA); Gordon, John Thomas (Ambridge, PA); Shockling, Larry Anthony (Pittsburgh, PA)

2000-01-01T23:59:59.000Z

493

Microfluidic Fuel Cells Erik Kjeang  

E-Print Network [OSTI]

Microfluidic Fuel Cells by Erik Kjeang M.Sc., Umeå University, 2004 A Dissertation Submitted Supervisory Committee Microfluidic Fuel Cells by Erik Kjeang M.Sc., Umeå University, 2004 Supervisory University External Examiner Microfluidic fuel cell architectures are presented in this thesis. This work

Victoria, University of

494

Hydrogen & Fuel Cells Program Overview  

E-Print Network [OSTI]

Hydrogen & Fuel Cells Program Overview Dr. Sunita Satyapal Program Manager 2011 Annual Merit Review and Peer Evaluation Meeting May 9, 2011 #12;Enable widespread commercialization of hydrogen and fuel cell transportation applications/light duty vehicles Updated Program Plan May 2011 Hydrogen and Fuel Cells Key Goals 2

495

Bilevel contact solar cells  

SciTech Connect (OSTI)

This patent describes a solar cell. It comprises a body of semiconductor material having at least one P/N junction therein, the body including a front face having no electrodes thereon, and a bilevel elevation back face having at least one P-doped region at a first level interdigitated with at least one N-doped region at a second level, wherein the at least one P-doped region and the at least one N-doped region partially overlap to form at least one compensated region; and a positive electrode contacting the at lease one P-doped region and a negative electrode contacting the at least one N-doped region, both electrodes contacting the solar cell on the back face.

Sinton, R.A.

1991-10-01T23:59:59.000Z

496

Electrocapturing flow cell  

DOE Patents [OSTI]

A flow cell for electrophoretically-assisted capturing analytes from a flow. The flow cell includes a specimen chamber, a first membrane, a second membrane, a first electrode chamber, and a second electrode chamber. The specimen chamber may have a sample inlet and a sample outlet. A first portion of the first membrane may be coupled to a first portion of the specimen chamber. A first portion of the second membrane may be coupled to a second portion of the specimen chamber. The first electrode chamber may be configured to accept a charge. A portion of the first electrode chamber may be coupled to a second portion of the first membrane. A second electrode chamber may be configured to accept an opposite charge. A portion of the second electrode chamber may be coupled to a second portion of the second membrane.

Morozov, Victor (Manassas, VA)

2011-04-05T23:59:59.000Z

497

Broad spectrum solar cell  

DOE Patents [OSTI]

An alloy having a large band gap range is used in a multijunction solar cell to enhance utilization of the solar energy spectrum. In one embodiment, the alloy is In.sub.1-xGa.sub.xN having an energy bandgap range of approximately 0.7 eV to 3.4 eV, providing a good match to the solar energy spectrum. Multiple junctions having different bandgaps are stacked to form a solar cell. Each junction may have different bandgaps (realized by varying the alloy composition), and therefore be responsive to different parts of the spectrum. The junctions are stacked in such a manner that some bands of light pass through upper junctions to lower junctions that are responsive to such bands.

Walukiewicz, Wladyslaw (Kensington, CA); Yu, Kin Man (Lafayette, CA); Wu, Junqiao (Richmond, CA); Schaff, William J. (Ithaca, NY)

2007-05-15T23:59:59.000Z

498

Compact fuel cell  

DOE Patents [OSTI]

A novel electrochemical cell which may be a solid oxide fuel cell (SOFC) is disclosed where the cathodes (144, 140) may be exposed to the air and open to the ambient atmosphere without further housing. Current collector (145) extends through a first cathode on one side of a unit and over the unit through the cathode on the other side of the unit and is in electrical contact via lead (146) with housing unit (122 and 124). Electrical insulator (170) prevents electrical contact between two units. Fuel inlet manifold (134) allows fuel to communicate with internal space (138) between the anodes (154 and 156). Electrically insulating members (164 and 166) prevent the current collector from being in electrical contact with the anode.

Jacobson, Craig (Moraga, CA); DeJonghe, Lutgard C. (Lafayette, CA); Lu, Chun (Richland, WA)

2010-10-19T23:59:59.000Z

499

Shielded cells transfer automation  

SciTech Connect (OSTI)

Nuclear waste from shielded cells is removed, packaged, and transferred manually in many nuclear facilities. Radiation exposure is absorbed by operators during these operations and limited only through procedural controls. Technological advances in automation using robotics have allowed a production waste removal operation to be automated to reduce radiation exposure. The robotic system bags waste containers out of glove box and transfers them to a shielded container. Operators control the system outside the system work area via television cameras. 9 figures.

Fisher, J J

1984-01-01T23:59:59.000Z

500

Cell culture compositions  

DOE Patents [OSTI]

The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6 (SEQ ID NO:1 encodes the full length endoglucanase; SEQ ID NO:4 encodes the mature form), and the corresponding endoglucanase VI amino acid sequence ("EGVI"; SEQ ID NO:3 is the signal sequence; SEQ ID NO:2 is the mature sequence). The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVI, recombinant EGVI proteins and methods for producing the same.

Dunn-Coleman, Nigel; Goedegebuur, Frits; Ward, Michael; Yiao, Jian

2014-03-18T23:59:59.000Z