National Library of Energy BETA

Sample records for bone ash bone

  1. Osteocytes and Bone Diseases 

    E-Print Network [OSTI]

    Ren, Yinshi

    2015-05-06

    For many centuries, the osteoblast is considered to be responsible for bone formation. It is also believed that an imbalance of osteoblasts (weak) and osteoclasts (strong) is the main cause for bone diseases such as ...

  2. Biodegradable synthetic bone composites

    DOE Patents [OSTI]

    Liu, Gao; Zhao, Dacheng; Saiz, Eduardo; Tomsia, Antoni P.

    2013-01-01

    The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

  3. Invest in Your Bones Bone Mineral Calcium and Vitamin D

    E-Print Network [OSTI]

    Invest in Your Bones Bone Mineral Calcium and Vitamin D Leaflet 4 One common misconception is that calcium is only needed for growing children. In reality, both calcium and vitamin D are needed to maintain of calcium from your bones. Vitamin D promotes the absorption of calcium in the gut, which is necessary

  4. Enhancement of Growth Performance and Bone Mineralization in Market Broilers through Dietary Enzymes 

    E-Print Network [OSTI]

    Coppedge, Jacob Ryan

    2012-02-14

    phosphorus (aP) in the control diets resulted in improved bird performance and bone ash data. The presence of dietary phytase in phosphorus deficient diets resulted in improvements in growth parameters and bone mineralization. Regression analysis... and processing parameters. In Experiments 3 and 4, a battery trial and a floor trial were conducted to determine the effects of phytase and NSPase enzyme co-administration on growth and bone ash in low phosphorus diets. Increasing the level of available...

  5. Evidence for a Serum Factor That Initiates the Re-calcification of Demineralized Bone*S

    E-Print Network [OSTI]

    Price, Paul A.

    Evidence for a Serum Factor That Initiates the Re-calcification of Demineralized Bone*S Received to demineralization, and the re-calcified bone is palpably hard. Re-calcified bone mineral is com- parable- induced re-calcification of demineralized bone suggest that the serum calcification factor identified

  6. Bone Mineral Density, Bone Turnover, and Systemic Inflammation in Non-cirrhotics with Chronic Hepatitis C

    E-Print Network [OSTI]

    Lai, JC; Shoback, DM; Zipperstein, J; Lizaola, B; Tseng, S; Terrault, NA

    2015-01-01

    Mun˜oz-Torres M, et al. Bone mineral density, serum insulin-et al. Osteoporosis and bone mineral metabolism disorders in1069-9. 11. George J. Bone mineral density and disorders of

  7. Biomimetic hydroxyapatite as a new consolidating agent for archaeological bone

    E-Print Network [OSTI]

    North, Alexis

    2014-01-01

    R.E.M.  2002.  “Bone  Diagenesis:  An  Overview  of  2000.  “Patterns  of  Diagenesis  in  Bone  I:  The  element  Studies  of  Diagenesis  in  Prehistoric  Bone. ”  

  8. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic...

  9. Relations between the ultrasonic elastic moduli of compact bone and tissue microstructure 

    E-Print Network [OSTI]

    Ahern, John Charles

    1994-01-01

    for Haversian compact bone as homogeneous solid. This study observed that mild changes in the microstructure can predict variations in the mechanical properties. All the tested material properties exhibit gradual increases for small positive changes in ash...

  10. Positive modulator of bone morphogenic protein-2

    DOE Patents [OSTI]

    Zamora, Paul O. (Gaithersburg, MD); Pena, Louis A. (Poquott, NY); Lin, Xinhua (Plainview, NY); Takahashi, Kazuyuki (Germantown, MD)

    2009-01-27

    Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

  11. Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma

    E-Print Network [OSTI]

    Dam, T.-T.; Harrison, S.; Fink, H. A.; Ramsdell, J.; Barrett-Connor, E.

    2010-01-01

    x ORIGINAL ARTICLE Bone mineral density and fractures inwas associated with lower bone mineral density (BMD) at theKeywords Bone loss . Bone mineral density . Elderly .

  12. Digital electronic bone growth stimulator

    DOE Patents [OSTI]

    Kronberg, J.W.

    1993-01-01

    The present invention relates to the electrical treatment of biological tissue. In particular, the present invention discloses a device that produces discrete electrical pulse trains for treating osteoporosis and accelerating bone growth. According to its major aspects and broadly stated, the present invention consists of an electrical circuit configuration capable of generating Bassett-type waveforms shown with alternative signals provide for the treatment of either fractured bones or osteoporosis. The signal generator comprises a quartz clock, an oscillator circuit, a binary divider chain, and a plurality of simple, digital logic gates. Signals are delivered efficiently, with little or no distortion, and uniformly distributed throughout the area of injury. Perferably, power is furnished by widely available and inexpensive radio batteries, needing replacement only once in several days. The present invention can be affixed to a medical cast without a great increase in either weight or bulk. Also, the disclosed stimulator can be used to treat osteoporosis or to strengthen a healing bone after the cast has been removed by attaching the device to the patient`s skin or clothing.

  13. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure....

  14. Composite bone substitutes prepared by two methods

    E-Print Network [OSTI]

    Lee, Hoe Yun; Lee, Hoe Yun

    2012-01-01

    Composites via Freeze Casting for Bone Tissue Engineering,”A.P. Tomsia, “Freeze casting of hydroxyapatite scaffolds forcamphene- based freeze casting,” Materials Letters 61(11-

  15. PPARs in Bone: The Role in Bone Cell Differentiation and Regulation of Energy Metabolism

    E-Print Network [OSTI]

    Toledo, University of

    PPARs in Bone: The Role in Bone Cell Differentiation and Regulation of Energy Metabolism Beata of bone homeostasis and energy metabolism. Peroxisome proliferator-activated receptors (PPARs) represent a family of proteins that control energy turnover in adipose, liver, and muscle tissue. These proteins also

  16. Histologic Comparison of Regenerate Bone Produced from Dentate Versus Edentulous Transport Discs in Bone Transport Distraction Osteogenesis 

    E-Print Network [OSTI]

    Sevilla Gaitan, Carlos

    2013-12-10

    Purpose: The purpose of this research was to quantify the number of blood vessels and nerves and mineral apposition rate (MAR) in native bone and compare it to the regenerate bone produced by bone transport distraction osteogenesis (BTDO...

  17. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking...

  18. Investigation into mechanical properties of bone and its main constituents

    E-Print Network [OSTI]

    Evdokimenko, Ekaterina

    2012-01-01

    Kinetic studies of bone demineralization at different HClKinetic studies of the demineralization and deproteinationJ. McKittrick, “Bone demineralization and deproteination

  19. Elastic anisotropy of bone Biomechanics, BME 315

    E-Print Network [OSTI]

    Lakes, Roderic

    17 22 Glong 3.6 5.3 0.58 0.30 Etransv 11.5 15 Gtr 3.3 6.3 0.31 0.11 Etransv 11.5 12 Gtr 3.3 7.0 0 moduli of bone, in Mechanical Properties of Bone, Joint ASME-ASCE Applied Mechanics, Fluids Engineering

  20. Investigation into mechanical properties of bone and its main constituents

    E-Print Network [OSTI]

    Evdokimenko, Ekaterina

    2012-01-01

    treatment of intrabony periodontal defects: 6 year resultsbones, to repair periodontal defects, bone removal from

  1. Elastic moduli of untreated, demineralized and deproteinized cortical bone: Validation of a theoretical model of bone as an interpenetrating composite material

    E-Print Network [OSTI]

    McKittrick, Joanna

    Elastic moduli of untreated, demineralized and deproteinized cortical bone: Validation online 15 November 2011 Keywords: Cortical bone Elastic moduli Multi-scale modeling Demineralization include completely demineralized and deproteinized bones as well as untreated bone samples. Porosity

  2. Mandible versus Long Bone Marrow Cells

    E-Print Network [OSTI]

    Chaichanasakul, Thawinee

    2012-01-01

    3-3 microCT analysis of gelatin sponge seeded with long boneFigure 3-4 H&E staining of gelatin sponge seeded with longprocess (Djagny et al. 2001). Gelatin- based sponge prepared

  3. Composite gelatin delivery system for bone regeneration

    E-Print Network [OSTI]

    Hager, Elizabeth A. (Elizabeth Ann)

    2005-01-01

    In this thesis, the chemical/mechanical properties and biocompatibility of gelatin were investigated to produce a gelatin scaffold for the release of bone morphogenetic proteins (BMPs) from composite particles. This delivery ...

  4. Nanoscale Surface Topography to Guide Bone Growth

    E-Print Network [OSTI]

    Nanoscale Surface Topography to Guide Bone Growth P R O J E C T L E A D E R : Jirun Sun (American T S Designed and fabricated devices with nanoscale surface topography. Controlled cell alignment by varying

  5. Microdamage accumulation in bovine trabecular bone

    E-Print Network [OSTI]

    Moore, Tara L. Arthur (Tara Lee Arthur), 1972-

    2001-01-01

    When bone is loaded beyond its failure point, it develops damage in the form of microcracks. Normally, microcracks are repaired by the remodeling process, limiting the number of in vivo microcracks. However, if the rate ...

  6. Fracture, aging and disease in bone

    E-Print Network [OSTI]

    Ager, J.W.; Balooch, G.; Ritchie, R.O.

    2006-01-01

    and R. O. Ritchie: Effect of aging on the toughness of humanof microstructure in the aging-related deterioration of thestudy of the effect of aging on human cortical bone J.

  7. Mechanical bone strength in the proximal tibia 

    E-Print Network [OSTI]

    Prommin, Danu

    2000-01-01

    Six bone slices from one canine tibia were tested by compressive load to determine the ultimate strength as a function of distance from the knee. Both the ultimate compressive strength and overall modulus of elasticity of ...

  8. The effect of three hemostatic agents on early bone healing in an animal model

    E-Print Network [OSTI]

    2010-01-01

    B, Sjogren S: Effects of bone wax on rabbit cranial boneRR: The effect of bone wax on the healing of experimentaland healing using bone wax and a soluble polymer material.

  9. Cellular and molecular immunotherapeutics derived from the bone marrow stroma

    E-Print Network [OSTI]

    Parekkadan, Biju

    2008-01-01

    The bone marrow contains a multipotent stromal cell, commonly referred to as a mesenchymal stem cell (MSC). There has been recent interest in the clinical use of MSCs for cell-based therapy because: (1) bone marrow aspiration ...

  10. BONE LOSS IN RELATION TO HYPOTHALAMIC ATROPHY IN ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Loskutova, Natalia Y.

    2011-05-12

    . The body of presented work extends the literature on a relationship between bone loss and AD. Overall, the presented work provides initial evidence that accelerated bone loss observed in individuals in the early stages of AD may be partially due...

  11. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    28 July 2010 00:00 Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking...

  12. Bone fragments a body can make

    SciTech Connect (OSTI)

    Stout, S.D.; Ross, L.M. Jr. )

    1991-05-01

    Data obtained from various analytical techniques applied to a number of small bone fragments recovered from a crime scene were used to provide evidence for the occurrence of a fatality. Microscopic and histomorphometric analyses confirmed that the fragments were from a human skull. X-ray microanalysis of darkened areas on the bone fragments revealed a chemical signature that matched the chemical signature of a shotgun pellet recovered at the scene of the crime. The above findings supported the deoxyribonucleic acid (DNA) fingerprint evidence which, along with other evidence, was used to convict a man for the murder of his wife, even though her body was never recovered.

  13. Composites structures for bone tissue reconstruction

    SciTech Connect (OSTI)

    Neto, W.; Santos, João; Avérous, L.; Schlatter, G.; Bretas, Rosario

    2015-05-22

    The search for new biomaterials in the bone reconstitution field is growing continuously as humane life expectation and bone fractures increase. For this purpose, composite materials with biodegradable polymers and hydroxyapatite (HA) have been used. A composite material formed by a film, nanofibers and HA has been made. Both, the films and the non-woven mats of nanofibers were formed by nanocomposites made of butylene adipate-co-terephthalate (PBAT) and HA. The techniques used to produce the films and nanofibers were spin coating and electrospinning, respectively. The composite production and morphology were evaluated. The composite showed an adequate morphology and fibers size to be used as scaffold for cell growth.

  14. Three-dimensional terahertz computed tomography of human bones

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    spectroscopy cannot rival with dual energy x-ray absorptiometry (DEXA) to identify the bone mineral density

  15. Mechanical loading attenuates loss of bone mass and bone strength induced by immobilization and calcium-deficiency 

    E-Print Network [OSTI]

    Inman, Cynthia Lynn

    1996-01-01

    Immobilization and calcium-deficiency have been documented to cause a decrease in strength and bone mineral loss, and exercise is known to strengthen bone. The purpose of this study was to determine the effects of mechanical ...

  16. Preparation of Bone Sam-ples for DNA Extraction: A

    E-Print Network [OSTI]

    , such as hammering frozen bone sealed in plastic freezer bags, have proven unreliable; shards of bone tend to pierce abrasive agent was included with the bone sample (in our case, sterilized glass fragments) to en- sure even-and-bolt as- sembly for reuse with other samples. However, considering the low cost of the nuts and bolts

  17. Bone scintigraphy in evaluating the viability of composite bone grafts revascularized by microvascular anastomoses, conventional autogenous bone grafts, and free non-revascularized periosteal grafts

    SciTech Connect (OSTI)

    Berggren, A.; Weiland, A.J.; Ostrup, L.T.

    1982-07-01

    Researchers studied the value of bone scintigraphy in the assessment of anastomotic patency and bone-cell viability in free bone grafts revascularized by microvascular anastomoses in twenty-seven dogs. The dogs were divided into three different groups, and scintigraphy was carried out using technetium-labeled methylene diphosphonate in composite bone grafts revascularized by microvascular anastomoses, conventional autogenous bone grafts, and periosteal grafts placed in different recipient beds. The viability of the grafts were evaluated by histological examination and fluorescence microscopy after triple labeling with oxytetracycline on the first postoperative day, alizarin complexone on the fourth postoperative day, and DCAF on the eleventh postoperative day. A positive scintiscan within the first week following surgery indicated patent microvascular anastomoses, and histological study and fluorescence microscopy confirmed that bone throughout the graft was viable. A positive scintiscan one week after surgery or later does not necessarily indicate microvascular patency or bone-cell survival, because new bone formed by creeping substitution on the surface of a dead bone graft can result in this finding.

  18. Bone Cancer Rates in Dinosaurs Compared with Modern Vertebrates

    E-Print Network [OSTI]

    L. C. Natarajan; A. L. Melott; B. M. Rothschild; L. D. Martin

    2007-10-16

    Data on the prevalence of bone cancer in dinosaurs is available from past radiological examination of preserved bones. We statistically test this data for consistency with rates extrapolated from information on bone cancer in modern vertebrates, and find that there is no evidence of a different rate. Thus, this test provides no support for a possible role of ionizing radiation in the K-T extinction event.

  19. Physiological Stress, Bone Growth and Development in Imperial Rome

    E-Print Network [OSTI]

    Beauchesne, Patrick Denis

    2012-01-01

    present and that diagenesis (chemical exchange between therisk assessment. Diagenesis, or the chemical exchangeto assess the level of diagenesis in a bone without chemical

  20. Investigation into mechanical properties of bone and its main constituents

    E-Print Network [OSTI]

    Evdokimenko, Ekaterina

    2012-01-01

    mineral to the elastic-plastic properties of bone. J Bonec properties, hardness, viscosity and plastic deformation ofin the plastic region is a function of collagen properties

  1. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and...

  2. Trabecular bone dosimetry using a Monte Carlo code 

    E-Print Network [OSTI]

    Zuzarte de Mendonca, Anne

    1993-01-01

    thickness 24 7. Example of the path of a volume-seeker in trabecular bone using EGS4. S is the source point 28 8. Absorbed &actions in the bone marmw in case of a uniform deposition in trabecular bone. CS in mm and f are indicated in parenthesis for each... percent per mass) 29 4. Electron absorbed fractions and COV (%) for monoenergetic electron sources uniformly distributed within the trabecular bone of the middle spine (CS&. 99 mm and f=1. 012) 31 5. Electmn absorbed fractions and COV...

  3. Ash, calcium, phosphorus and magnesium content of the metacarpus of hereford cows under different nutritional and physiological conditions 

    E-Print Network [OSTI]

    Haque, Mozammel

    1967-01-01

    ASH, CALCIUM, PHOSPHORUS AND MAGNESIUM CONTENT OF THE METACARPUS OF HEREFORD COWS UNDER DIFFERENT NUTRITIONAL AND PHYSIOLOGICAL CONDITIONS A Thesis By MOZAMMEL HAQUE Submitted to the Graduate College of the Texas A&M University in partial... centages of Calcium, Phosphorus snd Magnesium in Bone Ash for Cows Gi;en Different Treatments During Pre- And Post-Partum Periods 22 10 Analysis of Variance oi Calcium in Bone Ash Dun an's )tultiple tvange Test 1'or Calcium in Bone Ash. Analy...

  4. Structural Analysis of Human and Bovine Bone for Development of Synthetic Materials 

    E-Print Network [OSTI]

    Jang, Eunhwa

    2012-10-19

    With increasing demands in bone repair and replacement, this research investigates the microstructure, properties and performance of bovine bone, human bone, and synthetic materials. Doing so, experimental approaches were used to exam and compare...

  5. High-speed photography of compressed human trabecular bone correlates whitening to microscopic damage

    E-Print Network [OSTI]

    Hansma, Paul

    ]. Trabecular bone is situated at the end of the long bones and in the spinal column, where it fills all of the inner vertebral space. In the long bones it transfers loads from joint surfaces onto the midshaft

  6. Author's personal copy Initial anisotropy in demineralized bovine cortical bone in compressive

    E-Print Network [OSTI]

    McKittrick, Joanna

    Author's personal copy Initial anisotropy in demineralized bovine cortical bone in compressive Cortical bone Cyclic compression Demineralization The mechanical properties of demineralized bovine and transverse directions. The bone was demineralized by 10% ethylenediaminetetraacetic acid (EDTA) (100% protein

  7. Microcapsule-Induced Toughening of Bone Cement Gina M. Miller

    E-Print Network [OSTI]

    Sottos, Nancy R.

    27 Microcapsule-Induced Toughening of Bone Cement Gina M. Miller Senior in Aerospace Engineering R. White, and TAM Prof. Nancy R. Sottos Acrylic bone cement is the primary material used cement, it may be possible to extend the lifetime of the implant, thus reducing the occurrence

  8. Bone loss during energy restriction: mechanistic role of leptin 

    E-Print Network [OSTI]

    Baek, Kyunghwa

    2009-05-15

    Mechanical unloading and food restriction (FR) are leading causes of bone loss, which increase the risk of fracture later in life. Leptin, a 16kDa cytokine like hormone principally produced by white adipocytes, may be involved in bone metabolism...

  9. p-FEMs in biomechanics: Bones and Arteries Zohar Yosibash

    E-Print Network [OSTI]

    Yosibash, Zohar

    p-FEMs in biomechanics: Bones and Arteries Zohar Yosibash Department of Mechanical Engineering, Ben-FEM) is extended to problems in the field of biomechanics: the mechanical response of bones and arteries-FEMs are extremely important for analysts that aim at validating mathe- matical models of biomechanical structures

  10. Protocadherin-7 induces bone metastasis of breast cancer

    SciTech Connect (OSTI)

    Li, Ai-Min; Tian, Ai-Xian; Zhang, Rui-Xue; Ge, Jie; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Sun, Xuan; Cao, Xu-Chen; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin

    2013-07-05

    Highlights: •PCDH7 is overexpression in high bone metastatic MDA-MB-231 cells. •PCDH7 is up-regulation in bone metastatic breast cancer tissues. •Suppression of PCDH7 inhibits cell proliferation, migration, and invasion in vitro. •PCDH7 induces breast cancer bone metastasis in vivo. -- Abstract: Breast cancer had a propensity to metastasize to bone, resulting in serious skeletal complications associated with poor outcome. Previous study showed that Protocadherin-7 (PCDH7) play an important role in brain metastatic breast cancer, however, the role of PCDH7 in bone metastatic breast cancer has never been explored. In the present study, we found that PCDH7 expression was up-regulation in bone metastatic breast cancer tissues by real-time PCR and immunohistochemistry assays. Furthermore, suppression of PCDH7 inhibits breast cancer cell proliferation, migration, and invasion in vitro by MTT, scratch, and transwell assays. Most importantly, overexpression of PCDH7 promotes breast cancer cell proliferation and invasion in vitro, and formation of bone metastasis in vivo. These data provide an important insight into the role of PCDH7 in bone metastasis of breast cancer.

  11. Drilling and Microfracture Lead to Different Bone Structure and Necrosis during Bone-Marrow Stimulation for Cartilage Repair

    E-Print Network [OSTI]

    Buschmann, Michael

    Drilling and Microfracture Lead to Different Bone Structure and Necrosis during Bone following microfracture and comparing to drilling in a mature rabbit model of cartilage repair. Microfracture holes were made to a depth of 2 mm and drill holes to either 2 mm or 6 mm under cooled irrigation

  12. A Novel Inverse Finite Element Analysis to Assess Bone Fracture Healing in Mice Receiving Bone Marrow Mesenchymal Stem Cell Transplantation

    E-Print Network [OSTI]

    Miga, Michael I.

    A Novel Inverse Finite Element Analysis to Assess Bone Fracture Healing in Mice Receiving Bone generation, and an iterative optimization (using finite element analysis) of the fracture callus material approach includes acquisition of microCT image volumes, biomechanical testing, finite element mesh

  13. DISCOVERY AND RESEARCH ON JIAHU BONE FLUTES IN WUYANG, CHINA.

    SciTech Connect (OSTI)

    JUZHONG, Z.; HARBOTTLE, G.; XINGHUA, X.; CHANGSUI, W.

    2000-11-01

    The site of Jiahu is located in Jiahu village, Wuyang County, Henan province, on the Western edge of the broad plain of Huanhuaihai. On its north the site borders the Sha River, in the upper reaches of the Huai River; its latitude is 33{degree} 36 minutes North, longitude 113{degree} 40 minutes East, and it is 67.5 meters above sea level. Between 1983 and 1987, the Henan Cultural Relics and Archaeology Institute carried out six campaigns of excavation here, revealing an area of 2400 square meters. Except for the trial excavation in the spring of 1983, Zhang Juzhong has been in charge of all the excavations. In early May 1986, while excavating tomb 78, Zhang Juzhong and Yang Zhenwei first discovered two funerary bone flutes. They soon found other, similar bone flutes in tombs 73, 94 and 121 respectively. Mr. Zhang's attention was instantly focused on these remarkable finds. In the campaign of autumn 1986, one or two more bone flutes were discovered in each of tombs 233,273, 263 and 270. Finally, in the spring of 1987, again one or two bone flutes were found in each of the tombs 282, 363,341,411,344 and 387. Up to the end of excavation in June 1987, altogether 25 bone flutes had been found, of which 17 were complete or almost complete, 6 broken or fragmentary and 2 were half-finished examples. Among the 17 complete bone flutes, there were 14 having seven holes, one five-hole, one six-hole and one eight-hole bone flute. In particular, the bone flute M282:20 was exquisitely made, and complete. Zhang Juzhong, the discoverer of the bone flutes, researcher Pei Mingxiang, the. ex-director of the division, who came to the digging site to see the progress of the work, and their coworkers were all understandably very excited.

  14. Processing of hydroxylapatite coatings on titanium alloy bone prostheses

    DOE Patents [OSTI]

    Nastasi, Michael A. (Espanola, NM); Levine, Timothy E. (Santa Clara, CA); Mayer, James W. (Phoenix, AZ); Pizziconi, Vincent B. (Phoenix, AZ)

    1998-01-01

    Processing of hydroxylapatite sol-gel films on titanium alloy bone prostheses. A method utilizing non-line-of-sight ion beam implantation and/or rapid thermal processing to provide improved bonding of layers of hydroxylapatite to titanium alloy substrates while encouraging bone ingrowth into the hydroxylapatite layers located away from the substrate, is described for the fabrication of prostheses. The first layer of hydroxylapatite is mixed into the substrate by the ions or rapidly thermally annealed, while subsequent layers are heat treated or densified using ion implantation to form layers of decreasing density and larger crystallization, with the outermost layers being suitable for bone ingrowth.

  15. Computer modeling approach for microsphere-packed bone scaffold Pallavi Lal, Wei Sun*

    E-Print Network [OSTI]

    Sun, Wei

    bone graft [5,6], for structural and human cellular assessment of scaffolds for bone repair [7 modeling approach for constructing a three-dimensional microsphere-packed bone graft structure is presented packing model to determine the number of microspheres packed in a synthesized bone graft. The pore size

  16. JOURNAL OF BONE AND MINERAL RESEARCH Volume 24, Number 11, 2009

    E-Print Network [OSTI]

    Burgoyne, Chris

    JOURNAL OF BONE AND MINERAL RESEARCH Volume 24, Number 11, 2009 Published online on May 4, 2009; doi: 10.1359/JBMR.090504 Ó 2009 American Society for Bone and Mineral Research Femoral Neck Trabecular fracture cases have sufficient trabecular bone for anabolic therapies to build on. J Bone Miner Res 2009;24:1808

  17. ORIGINAL RESEARCH Minerals Form a Continuum Phase in Mature Cancellous Bone

    E-Print Network [OSTI]

    Price, Paul A.

    of fully deprotei- nized and demineralized bovine femur cancellous bone samples show that fine trabecular

  18. Effects of microstructure and water on the electrical potentials in bone induced by ultrasound irradiation

    SciTech Connect (OSTI)

    Tsuneda, H.; Matsukawa, S.; Takayanagi, S.; Matsukawa, M.; Mizuno, K.; Yanagitani, T.

    2015-02-16

    The healing mechanism of bone fractures by low intensity pulse ultrasound is yet to be fully understood. There have been many discussions regarding how the high frequency dynamic stress can stimulate numerous cell types through various pathways. As one possible initial process of this mechanism, we focus on the piezoelectricity of bone and demonstrate that bone can generate electrical potentials by ultrasound irradiation in the MHz range. We have fabricated ultrasonic bone transducers using bovine cortical bone as the piezoelectric device. The ultrasonically induced electrical potentials in the transducers change as a function of time during immersed ultrasonic pulse measurements and become stable when the bone is fully wet. In addition, the magnitude of the induced electrical potentials changes owing to the microstructure in the cortical bone. The potentials of transducers with haversian structure bone are higher than those of plexiform structure bone, which informs about the effects of bone microstructure on the piezoelectricity.

  19. An experimental study of diffusional properties of small ions and nonelectrolytes in compact bone 

    E-Print Network [OSTI]

    Bilge, Huseyin Fertac

    1978-01-01

    structure have been reviewed by Richeile and Onkelinx [43] who discuss the composition, structure and the dynamics of bone mineral. Bauer, et al. [2] have presented the homeostatic function of bone in relation to bone metabolism. They have shown... functions, it has been recog- nized for many years that bone tissue has important physiological func- tions relating to whole body metabolism and that its microscopic struc- ture is equally well adapted to these functions. It is well known that bone...

  20. Compact biomedical pulsed signal generator for bone tissue stimulation

    DOE Patents [OSTI]

    Kronberg, J.W.

    1993-06-08

    An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

  1. Compact biomedical pulsed signal generator for bone tissue stimulation

    DOE Patents [OSTI]

    Kronberg, James W. (108 Independent Blvd., Aiken, SC 29801)

    1993-01-01

    An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

  2. Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels

    E-Print Network [OSTI]

    Heller, Daniel A.

    A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free ...

  3. On the mechanistic origins of toughness in bone

    SciTech Connect (OSTI)

    Launey, Maximilien E.; Buehler, Markus J.; Ritchie, Robert O.

    2009-10-07

    One of the most intriguing protein materials found in Nature is bone, a material composed out of assemblies of tropocollagen molecules and tiny hydroxyapatite mineral crystals, forming an extremely tough, yet lightweight, adaptive and multi-functional material. Bone has evolved to provide structural support to organisms, and therefore, its mechanical properties are of great physiological relevance. In this article, we review the structure and properties of bone, focusing on mechanical deformation and fracture behavior from the perspective of the multi-dimensional hierarchical nature of its structure. In fact, bone derives its resistance to fracture with a multitude of deformation and toughening mechanisms at many of these size-scales, ranging from the nanoscale structure of its protein molecules to its macroscopic physiological scale.

  4. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high...

  5. Research Finds Vitamin D Deficiency Affects Bone Quality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the ALS has also found that vitamin D deficiency plays a significant role in the bone-aging process. Low levels of vitamin D, the "sunshine vitamin," have been previously linked...

  6. The bones of the Milky Way

    SciTech Connect (OSTI)

    Goodman, Alyssa A.; Beaumont, Christopher N. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Alves, João [University of Vienna, 1180 Vienna (Austria); Benjamin, Robert A. [University of Wisconsin-Whitewater, Whitewater, WI 53190 (United States); Borkin, Michelle A. [Harvard University, Cambridge, MA 02138 (United States); Burkert, Andreas [University of Munich, Munich (Germany); Dame, Thomas M. [Smithsonian Astrophysical Observatory, Cambridge, MA 02138 (United States); Jackson, James [Boston University, Boston, MA 02215 (United States); Kauffmann, Jens [California Institute of Technology, Pasadena, CA 91125 (United States); Robitaille, Thomas [Max Planck Institute for Astronomy, Heidelberg (Germany); Smith, Rowan J. [Institut für Theoretische Astrophysik, Zentrum für Astronomie der Universiät Heidelberg, Heidelberg (Germany)

    2014-12-10

    The very long and thin infrared dark cloud 'Nessie' is even longer than had been previously claimed, and an analysis of its Galactic location suggests that it lies directly in the Milky Way's mid-plane, tracing out a highly elongated bone-like feature within the prominent Scutum-Centaurus spiral arm. Re-analysis of mid-infrared imagery from the Spitzer Space Telescope shows that this infrared dark cloud (IRDC) is at least two and possibly as many as five times longer than had originally been claimed by Nessie's discoverers; its aspect ratio is therefore at least 300:1 and possibly as large as 800:1. A careful accounting for both the Sun's offset from the Galactic plane (?25 pc) and the Galactic center's offset from the (l{sup II} , b{sup II} ) = (0, 0) position shows that the latitude of the true Galactic mid-plane at the 3.1 kpc distance to the Scutum-Centaurus Arm is not b = 0, but instead closer to b = –0.4, which is the latitude of Nessie to within a few parsecs. An analysis of the radial velocities of low-density (CO) and high-density (NH{sub 3}) gas associated with the Nessie dust feature suggests that Nessie runs along the Scutum-Centaurus Arm in position-position-velocity space, which means it likely forms a dense 'spine' of the arm in real space as well. The Scutum-Centaurus Arm is the closest major spiral arm to the Sun toward the inner Galaxy, and, at the longitude of Nessie, it is almost perpendicular to our line of sight, making Nessie the easiest feature to see as a shadow elongated along the Galactic plane from our location. Future high-resolution dust mapping and molecular line observations of the harder-to-find Galactic 'bones' should allow us to exploit the Sun's position above the plane to gain a (very foreshortened) view 'from above' the Milky Way's structure.

  7. Ibuprofen Administered Pre- or Post- Simulated Resistance Exercise Training Does Not Diminsh Gains in Bone Formation or Bone Mass 

    E-Print Network [OSTI]

    Cunningham, David

    2012-02-14

    Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to suppress bone formation when administered before, but not if administered after, an acute bout of mechanical load in rats. The NSAID ibuprofen inhibits ...

  8. Noninvasive and quantitative evaluation of bone marrow infiltration and bone marrow microcirculation in patients with monoclonal plasma cell disease by means of diffusion

    E-Print Network [OSTI]

    Gertz, Michael

    .0001) and D (p study clearly shows that bone marrow infiltrationRajiv Shah Dr. med. Noninvasive and quantitative evaluation of bone marrow infiltration and bone diseases. The response to treatment is evaluated mostly on the basis of hematologic parameters. This study

  9. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 679 (2015) | doi:10.1038/bonekey.2015.46

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number `Defining the Bone Metastasis Niche'. CABS ORAL COMMUNICATIONS The 4th Joint Meeting of ECTS and IBMS

  10. Common variants in the region around Osterix are associated with bone mineral density and growth in childhood

    E-Print Network [OSTI]

    Peltonen, Leena

    Peak bone mass achieved in adolescence is a determinant of bone mass in later life. In order to identify genetic variants affecting bone mineral density (BMD), we performed a genome-wide association study of BMD and related ...

  11. Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography

    E-Print Network [OSTI]

    Burghardt, A. J.; Kazakia, G. J.; Link, T. M.; Majumdar, S.

    2009-01-01

    of osteoporotic fractures. J Bone Miner Res 16:1108–1119 3.of Osteoporotic Fractures. J Bone Miner Res 18:1947–1954 4.and calcaneus. J Bone Miner Res 14:1167–1174 7. Muller R,

  12. Engineered [beta]TCP-binding HER-family protein fusions and their use for improving osteoprogenitor- mediated bone regeneration

    E-Print Network [OSTI]

    Rivera Abreu, Jaime J. (Jaime Jose)

    2015-01-01

    Autologous bone marrow grafting has been shown to aid in the healing of bone defects since the 1950s. Transplantation of freshly-aspirated autologous bone marrow, together with a scaffold, is a promising clinical alternative ...

  13. PDGFBB promotes PDGFR{alpha}-positive cell migration into artificial bone in vivo

    SciTech Connect (OSTI)

    Yoshida, Shigeyuki; Center for Human Metabolomic Systems Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 ; Iwasaki, Ryotaro; Kawana, Hiromasa; Miyauchi, Yoshiteru; Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582; Department of Integrated Bone Metabolism and Immunology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 ; Hoshi, Hiroko; Miyamoto, Hiroya; Mori, Tomoaki; Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 ; Kanagawa, Hiroya; Katsuyama, Eri; Fujie, Atsuhiro; Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 ; Hao, Wu; and others

    2012-05-18

    Highlights: Black-Right-Pointing-Pointer We examined effects of PDGFBB in PDGFR{alpha} positive cell migration in artificial bones. Black-Right-Pointing-Pointer PDGFBB was not expressed in osteoblastic cells but was expressed in peripheral blood cells. Black-Right-Pointing-Pointer PDGFBB promoted PDGFR{alpha} positive cell migration into artificial bones but not osteoblast proliferation. Black-Right-Pointing-Pointer PDGFBB did not inhibit osteoblastogenesis. -- Abstract: Bone defects caused by traumatic bone loss or tumor dissection are now treated with auto- or allo-bone graft, and also occasionally by artificial bone transplantation, particularly in the case of large bone defects. However, artificial bones often exhibit poor affinity to host bones followed by bony union failure. Thus therapies combining artificial bones with growth factors have been sought. Here we report that platelet derived growth factor bb (PDGFBB) promotes a significant increase in migration of PDGF receptor {alpha} (PDGFR{alpha})-positive mesenchymal stem cells/pre-osteoblastic cells into artificial bone in vivo. Growth factors such as transforming growth factor beta (TGF{beta}) and hepatocyte growth factor (HGF) reportedly inhibit osteoblast differentiation; however, PDGFBB did not exhibit such inhibitory effects and in fact stimulated osteoblast differentiation in vitro, suggesting that combining artificial bones with PDGFBB treatment could promote host cell migration into artificial bones without inhibiting osteoblastogenesis.

  14. On the effect of x-ray irradiation on the deformation and fracture behavior of human cortical bone

    E-Print Network [OSTI]

    Barth, Holly D.

    2010-01-01

    effects  of  gamma  irradiation  on  allograft  biology S.   Effects  of  gamma? irradiation  on  the  human bone  after  gamma  irradiation.   J.   Bone  Joint  Surg. ?

  15. Modelling and simulation of acrylic bone cement injection and curing within the framework of vertebroplasty

    E-Print Network [OSTI]

    Landgraf, Ralf; Kolmeder, Sebastian; Lion, Alexander; Lebsack, Helena; Kober, Cornelia

    2013-01-01

    The minimal invasive procedure of vertebroplasty is a surgical technique to treat compression fractures of vertebral bodies. During the treatment liquid bone cement gets injected into the affected vertebral body and therein cures to a solid. In order to investigate the treatment and the impact of injected bone cement on the vertebra, an integrated modelling and simulation framework has been developed. The framework includes (i) the generation of computer models based on microCT images of human cancellous bone, (ii) CFD simulations of bone cement injection into the trabecular structure of a vertebral body as well as (iii) non-linear FEM simulations of the bone cement curing. Thereby, microstructural models of trabecular bone structures are employed. Furthermore, a detailed description of the material behaviour of acrylic bone cements is provided. More precisely, a non-linear fluid flow model is chosen for the representation of the bone cement behaviour during injection and a non-linear viscoelastic material mo...

  16. Compressive behavior of trabecular bone in the proximal tibia using a cellular solid model 

    E-Print Network [OSTI]

    Prommin, Danu

    2005-11-01

    In this study, trabecular architecture is considered as a cellular solid structure, including both intact and damaged bone models. ??Intact?? bone models were constructed based on ideal versions of 25, 60 and 80-year-old ...

  17. Bone Tissue Engineering Using Colloidal Gels and Native Extracellular Matrix Biomaterials

    E-Print Network [OSTI]

    Dennis, Stephen Connor

    2015-05-31

    scaffolding technology for the regeneration of bone tissue in non-load bearing critical-sized defects. This represents the first attempt to form colloids exclusively from biomaterials found in the microenvironment of healing bone fractures including hyaluronic...

  18. Bone Canonical WNT/B-Catenin Signaling in Models of Reduced Microgravity 

    E-Print Network [OSTI]

    Macias, Brandon 1979-

    2012-10-25

    translates into molecular osteogenic signals in bone cells is unknown. Radiation exposure is another potent inducer of bone loss, namely observed on Earth in the clinical setting following radiotherapy procedures. It is expected that long duration space...

  19. Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins

    E-Print Network [OSTI]

    Yong, Tseh-Hwan

    2005-01-01

    Current treatment of bone defects due to trauma, cancer, or degenerative spine diseases involves the implantation of a bone graft. Autografts, which are harvested from the patient's own body, are associated with problems ...

  20. Analysis and design of an adjustable bone plate for mandibular fracture fixation

    E-Print Network [OSTI]

    Cervantes, Thomas Michael

    2011-01-01

    This thesis presents the design, analysis and testing of a bone plate for mandibular fracture fixation. Conventional bone plates are commonly used to set fractures of the mandible in a surgical setting. If proper alignment ...

  1. Impact of Omega-3 Polyunsaturated Fatty Acids on Bone Adaptations to Simulated Resistance Training 

    E-Print Network [OSTI]

    Camp, Kaleigh Ann

    2013-04-30

    Young and ovariectomized animals eating diets rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs) exhibit enhanced bone formation and decrease bone loss, respectively. Eicosapentaenoic acid, an n-3 PUFA found in fish ...

  2. Correlation of mechanical viscoelastic properties to microstructure of equine cortical bone tissue 

    E-Print Network [OSTI]

    Ayers, Andrew Kerr

    1995-01-01

    were taken from equine third metacarpal bones and machined into rectangular slabs approximately 46 mm long, 10 mm wide, and 2 mm thick. After initial testing to determine the linear viscoelastic region of equine compact bone, the specimens were tested...

  3. High-speed photography of the development of microdamage in trabecular bone during compression

    E-Print Network [OSTI]

    Hansma, Paul

    is situated at the end of the long bones and in the spinal column, where it fills all of the inner vertebral, osteoarthritic, and osteoporotic human vertebral trabecular bone compressed at high strain rates. Apparent

  4. High-Speed Photography of Human Trabecular Bone during Compression Philipp J. Thurner1

    E-Print Network [OSTI]

    Hansma, Paul

    column, where it fills all of the inner vertebral space. In the long bones it transfers loads from joint study, we investigated healthy, osteoarthritic, and osteoporotic human vertebral trabecular bone

  5. Detection of bone disease in dogs by radioisotope scanning 

    E-Print Network [OSTI]

    Morris, Earl Louis

    1971-01-01

    in dogs for the diagnosis and progression of bone disease was studied. Twc isotopes of strontium, Sr and 85 87m Sr, were studied. The Sr was purchased 85 commercially and the Sr was produced at the 87m Texas A8cM University Nuclear Science Center... by the irradiation oi' Sr(N05)2. Criteria for bone scanning in dogs using Sr 85 and Sr were determined. Pour normal young dogs 87m were injected with Sr and four with Sr. Doses 85 87m of 100 p&i of Sr and 1 mCi of Sr were found . to 85 87m produoe satisfactory...

  6. Measurement of bone mineral content in caged and active cats 

    E-Print Network [OSTI]

    Tveter, Diane Ellen

    1988-01-01

    errors but these can be reduced by using two different x-ray energies. Dual energy CT operates on a basis similar to dual photon absorptiometry (explained below). The difference in attenuation between tissue and bone is greater for a lower energy... to act as a soft tissue equivalent (35). Effects of fat and soft tissue are decreased when dual energy CT is used (33). Data from each of the two different photon energies are combined and result in images of soft tissue and bone mineral regions. Beam...

  7. Is decreased bone mineral density associated with development of scoliosis? A bipedal osteopenic rat model

    E-Print Network [OSTI]

    Dede, Ozgur; Akel, Ibrahim; Demirkiran, Gokhan; Yalcin, Nadir; Marcucio, Ralph; Acaroglu, Emre

    2011-01-01

    more time standing erect. Dual energy X-ray absorbtiometry (acid; DEXA: Dual energy X-ray absorptiometry; BMD: Bone

  8. Murine retroviral bone marrow transplantation models for the study of human myeloproliferative disorders.

    E-Print Network [OSTI]

    Gavrilescu, L Cristina; Van Etten, Richard A

    2008-01-01

    forceps Bone rongeurs Styrofoam dissecting board 21-Gthe animal’s feet to a Styrofoam dissecting board with 21-G

  9. Antler Stiffness in Moose (Alces alces): Correlated Evolution of Bone Function and Material Properties?

    E-Print Network [OSTI]

    Blob, Richard W.

    , Clemson, South Carolina 29634 ABSTRACT The material properties of bone can vary considerably among in bone material properties might be correlated with differing functional demands at any of these scales- tudes like the Yukon has the potential to compromise bone material properties. However, moose have

  10. Flexible Statistical Models for Growth Fragments: a Study of Bone Mineral Acquisition

    E-Print Network [OSTI]

    Hastie, Trevor

    Flexible Statistical Models for Growth Fragments: a Study of Bone Mineral Acquisition Trevor J describe some statistical modeling of longitudinal data from a pediatric study of bone mineral acquisition- surements of bone mineral density are available for each subject, taken roughly one year apart, and between

  11. JOURNAL OF BONE AND MINERAL RESEARCH Volume 24, Number 2, 2009

    E-Print Network [OSTI]

    Ritchie, Robert

    JOURNAL OF BONE AND MINERAL RESEARCH Volume 24, Number 2, 2009 Published online on October 13, 2008; doi: 10.1359/JBMR.81005 Ó 2009 American Society for Bone and Mineral Research Prolonged Treatments With Antiresorptive Agents and PTH Have Different Effects on Bone Strength and the Degree of Mineralization in Old

  12. Fracture resistance of human cortical bone across multiple length-scales at physiological strain rates

    E-Print Network [OSTI]

    Ritchie, Robert

    Fracture resistance of human cortical bone across multiple length-scales at physiological strain Accepted 22 March 2014 Available online 13 April 2014 Keywords: Bone Strain rate Fracture toughness Plasticity X-ray diffraction a b s t r a c t While most fracture-mechanics investigations on bone have been

  13. Anisotropy in the compressive mechanical properties of bovine cortical bone and the mineral and protein constituents

    E-Print Network [OSTI]

    McKittrick, Joanna

    Cortical bone Compression Demineralization Deproteinization a b s t r a c t The mechanical properties of fully demineralized, fully deproteinized and untreated cortical bovine femur bone were investigated. Demineralization and deproteinization of the bone demonstrated that contiguous, stand-alone structures result

  14. Donor-Derived, Liver-Specific Protein Expression after Bone Marrow Transplantation

    E-Print Network [OSTI]

    Kay, Mark A.

    Donor-Derived, Liver-Specific Protein Expression after Bone Marrow Transplantation D. Denison mechanism to deliver a functional gene to a deficient liver. Bone marrow-derived hepatocytes are rare to treat liver disease is unclear. We sought to quantify bone marrow-derived hepatocyte protein expression

  15. Spectral Analysis and Connectivity of Porous Microstructures in Bone

    E-Print Network [OSTI]

    Golden, Kenneth M.

    that quantifies brine connectivity and its thermal evolution can also help assess the impact of osteoporosis on trabecular structure. Central to our approach is the spectral measure of a composite material, which contains, in dense cortical bone the pores can be sparse and disconnected, yet exhibit increasing volume fraction

  16. Refinement of the $n-?$ and $p-?$ fish-bone potential

    E-Print Network [OSTI]

    E. Smith; R. Woodhouse; Z. Papp

    2012-09-04

    The fishbone potential of composite particles simulates the Pauli effect by nonlocal terms. We determine the $n-\\alpha$ and $p-\\alpha$ fish-bone potential by simultaneously fitting to the experimental phase shifts. We found that with a double Gaussian parametrization of the local potential can describe the $n-\\alpha$ and $p-\\alpha$ phase shifts for all partial waves.

  17. GEORGIA TECHEMORYPKU SEED GRANT PROGRAM Nanostructure at Bone

    E-Print Network [OSTI]

    Das, Suman

    nanofibers to mimic the collagen fiber structure of bone matrix. #12;· Electrospinning is a simple and natural polymers. Electrospinning #12;PMMA PEO #12;Alginate fiber SEM image of the alginate in THF/DMF solvent Fabricate the fibrous scaffolds by electrospinning Calcine the samples to remove

  18. Scaffolds for bone repair using computer aided design and manufacture 

    E-Print Network [OSTI]

    Vadillo, Philippe Tadeusz

    2009-01-01

    of the extruder, the diameter of the pores can be precisely controlled to an accuracy of 10?m, in the manufactured scaffolds the pore size ranges from 100 to 300?m as that is what is found in trabecular bone. Natural and synthetic polymers were plotted which...

  19. Prediction and Informative Risk Factor Selection of Bone Diseases

    E-Print Network [OSTI]

    Buffalo, State University of New York

    --Electronic health records (EHRs); risk factor analysis; integrated feature extraction; risk factor selection1 Prediction and Informative Risk Factor Selection of Bone Diseases Hui Li, Xiaoyi Li, Murali and the overwhelming amount of electronic health records (EHRs) shared by healthcare institutions and practitioners, we

  20. Methods for testing the strength of cancellous bone and tested method effects on cortical bone in the ovariectomized rat 

    E-Print Network [OSTI]

    Ruhmann, Sean Phillip

    1998-01-01

    In this study, two mechanical testing procedures were developed to test the strength of cancellous bone from the proximal tibia of the rat, the "punch method" and the "whole slice method". These were used to quantify the effect of ovariectomy on rat...

  1. Bone quality measurements Osteoporos Int. 2011 Aug;22(8):2225-40. New laboratory tools in the assessment

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    and affect ~30 % of women after the menopause and ~10 % of men. Dual Energy bone densitometry (DXA) has and computer techniques are now available. Table 1: main abbreviations used in the present review DXA Dual Energy bone densitometry BMD bone mineral density BSU bone structure unit microCT microcomputed

  2. Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone

    E-Print Network [OSTI]

    Barth, Holly

    2012-01-01

    severe  loss  in  the  plastic  properties  of  bone  with  the  plastic,  rather  than  elastic,  properties  of  

  3. The degree of bone mineralization is maintained with single intravenous bisphosphonates in aged estrogen-deficient rats and

    E-Print Network [OSTI]

    Ritchie, Robert

    The degree of bone mineralization is maintained with single intravenous bisphosphonates in aged greater than can be explained by an increase in bone mineral density. In this study, 18-month Fischer 344 to measure lumbar vertebral bone microarchitecture, the degree of bone mineralization (DBM

  4. BONE CHARACTERIZATION ASME_Fatemi_chap13.indd 251 3/18/2008 5:01:36 AM

    E-Print Network [OSTI]

    quality. Assessment of mechanical properties of human bone in vivo by mechanical vibration analysis for the in vivo determination of bone mechanical characteristics. The potential of vibration analysis applied), to infer progressive me- chanical damage in human bone, in vitro. Standard measures of bone mechanical

  5. Long-term effects of lead poisoning on bone mineralization in vultures exposed to ammunition sources

    E-Print Network [OSTI]

    Donázar, José A.

    ´n en Recursos Cinege´ticos, IREC (CSIC, UCLM, JCCM), Ronda de Toledo s/n, 13071 Ciudad Real, Spain Bone

  6. Volumetric femoral BMD, bone geometry, and serum sclerostin levels differ between type 2 diabetic postmenopausal women with and without fragility fractures

    E-Print Network [OSTI]

    2015-01-01

    in women and men. J Bone Miner Res 26:373–379 46. Durosierwith diabetes. J Bone Miner Res 27:301–308 8. Patsch JM,fragility fractures. J Bone Miner Res 28: 9. Patsch JM, Li

  7. Dickkopf-1 in Craniofacial Bone and Tooth Development 

    E-Print Network [OSTI]

    Rodgers, Anika Sarah

    2014-08-20

    stream_source_info RODGERS-DISSERTATION-2014.pdf.txt stream_content_type text/plain stream_size 175992 Content-Encoding UTF-8 stream_name RODGERS-DISSERTATION-2014.pdf.txt Content-Type text/plain; charset=UTF-8... DICKKOPF-1 IN CRANIOFACIAL BONE AND TOOTH DEVELOPMENT A Dissertation by ANIKA SARAH RODGERS Submitted to the Office of Graduate and Professional Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR...

  8. Hydroxyapatite-binding peptides for bone growth and inhibition

    DOE Patents [OSTI]

    Bertozzi, Carolyn R. (Berkeley, CA); Song, Jie (Shrewsbury, MA); Lee, Seung-Wuk (Walnut Creek, CA)

    2011-09-20

    Hydroxyapatite (HA)-binding peptides are selected using combinatorial phage library display. Pseudo-repetitive consensus amino acid sequences possessing periodic hydroxyl side chains in every two or three amino acid sequences are obtained. These sequences resemble the (Gly-Pro-Hyp).sub.x repeat of human type I collagen, a major component of extracellular matrices of natural bone. A consistent presence of basic amino acid residues is also observed. The peptides are synthesized by the solid-phase synthetic method and then used for template-driven HA-mineralization. Microscopy reveal that the peptides template the growth of polycrystalline HA crystals .about.40 nm in size.

  9. Effects of dietary silicon on bone characteristics of poultry 

    E-Print Network [OSTI]

    Plyler, James Edward

    1977-01-01

    with day-old cockerels, eight-week-old turkey poults, and spent hens, to determine the effects of feeding dietary silicon in the form of sodium meta-silicate on bone character- istics. Growth effects were also determined for the cockerels and poults.... In experiments one and, rt:wo, 832 day-old Single Comb White Leghorn cockerel were fed corn-soy chick starter diets at two calcium levels, 0. 42% and 1. 00%. 'Each level was supplemented with 0, 25, 50, 100, or 200 p. p. m. silicon, in the form of sodium meta...

  10. Zhejiang Bone New Material Technology Co Ltd | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop IncIowa (UtilityMichigan) JumpZhuyuan ElectricTumuxiHydropower DevelopmentBone New

  11. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 675 (2015) | doi:10.1038/bonekey.2015.42

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number declared no competing interests. ORAL POSTERS ­ PRE-CLINICAL The 4th Joint Meeting of ECTS and IBMS

  12. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 685 (2015) | doi:10.1038/bonekey.2015.53

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number of ECTS and IBMS Rotterdam, The Netherlands 25­28 April 2015 POSTMENOPAUSAL OSTEOPOROSIS, DIAGNOSTIC TOOLS

  13. Microfluidic device for bone cell mechanobiology study The use of microfluidics provides many advantages for in vitro biological experiments over typical macro-

    E-Print Network [OSTI]

    Milgram, Paul

    Microfluidic device for bone cell mechanobiology study The use of microfluidics provides many microfluidics to investigate real-time interactions of different bone cells while undergoing physiologically

  14. A Novel Method for the Evaluation of Mechanical Properties of Cancellous Bone in the Rat Distal Femur 

    E-Print Network [OSTI]

    Lucas, Matthew W.

    2010-01-14

    The mechanical properties of the cancellous bone in the laboratory rat animal model are of great interest to the research community for the evaluation of treatments for osteoporosis. Cancellous bone responds rapidly and ...

  15. Development/Plasticity/Repair The Bone Morphogenetic Protein Roof Plate Chemorepellent

    E-Print Network [OSTI]

    Butler, Samantha

    Development/Plasticity/Repair The Bone Morphogenetic Protein Roof Plate Chemorepellent Regulates, Toronto, Ontario, Canada M5G 1X8 Commissural spinal axons extend away from the roof plate (RP) in response to the dorsal midline and are generated by the bone morphogenetic proteins (BMPs) in the roof plate (RP) (Liem

  16. Vitamin K2 Regulation of Bone Homeostasis Is Mediated by the Steroid and Xenobiotic Receptor SXR*

    E-Print Network [OSTI]

    Blumberg, Bruce

    Vitamin K2 Regulation of Bone Homeostasis Is Mediated by the Steroid and Xenobiotic Receptor SXR Institute, The City of Hope National Medical Center, Duarte, California 91010-3000 Vitamin K2 is a critical nutrient required for blood clotting that also plays an important role in bone forma- tion. Vitamin K2

  17. Collaborative Research Opportunities with Henry Ford Health System: Bones, Brains, Blood Pressure, and Beyond

    E-Print Network [OSTI]

    Finley Jr., Russell L.

    , and Beyond Professional and Academic Development (PAD) Seminar Series Tuesday, January 10, 2012 ­ 9:00 to 10Collaborative Research Opportunities with Henry Ford Health System: Bones, Brains, Blood Pressure Research at HFHS HFHS Department of Orthopaedic Surgery's Bone and Joint Center HFHS Department of Internal

  18. A comparative study of young and mature bovine cortical bone q Zherrina Manilay a

    E-Print Network [OSTI]

    McKittrick, Joanna

    .% proteins (mostly collagen-I, with a small amount of non-collageneous proteins) and 10 wt.% water [1 is present in the areas that need to absorb energy (skull, ribs, vertebra). Cortical bone further consists growing animals and is an indicator of non-human bone [4]. Katz and Yoon [5] showed that plexiform areas

  19. Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors. 

    E-Print Network [OSTI]

    Logan, John Gordon

    2012-11-30

    Bone metastases are a frequent clinical complication associated with cancer. The aim of this PhD thesis was to set up a model system for the study of tumour cell – bone cell interactions in vitro, ex vivo and in vivo and ...

  20. Mechanistic aspects of the fracture toughness of elk antler bone M.E. Launey a

    E-Print Network [OSTI]

    Ritchie, Robert

    hydroxyapatite nanoparticles that form a tough, light- weight, adaptive and multi-functional material. Bone-curves a b s t r a c t Bone is an adaptive material that is designed for different functional requirements these functions, it is a dynamic organ that is constantly remodeling and changing shape to adapt to the forces

  1. A Novel 3D Segmentation of Vertebral Bones from Volumetric CT Images Using Graph Cuts

    E-Print Network [OSTI]

    Farag, Aly A.

    of the vertebral bones of spine column with a particular focus on the lumbar spine. The primary goalA Novel 3D Segmentation of Vertebral Bones from Volumetric CT Images Using Graph Cuts Melih S to the Vertebral bodies (VBs). In this paper, we present a novel and fast 3D segmentation framework of VBs

  2. 1174 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 53, NO. 6, JUNE 2006 Microwave Drilling of Bones

    E-Print Network [OSTI]

    Gefen, Amit

    employs lasers for bone drilling [3], however, this method may be too costly for large-scale use1174 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 53, NO. 6, JUNE 2006 Microwave Drilling*, Member, IEEE Abstract--This paper presents a feasibility study of drilling in fresh wet bone tissue

  3. Fracture, aging, and disease in bone J.W. Ager III

    E-Print Network [OSTI]

    Ritchie, Robert

    Fracture, aging, and disease in bone J.W. Ager III Materials Sciences Division, Lawrence Berkeley-known increase with age in fracture risk of human bone is essential. This also represents a challenge from accompanying the process of aging using appropriate multiscale experimental methods and relating them

  4. Effect of aging on the toughness of human cortical bone: evaluation by R-curves

    E-Print Network [OSTI]

    Ritchie, Robert

    Effect of aging on the toughness of human cortical bone: evaluation by R-curves R.K. Nallaa,b , J online 27 October 2004 Abstract Age-related deterioration of the fracture properties of bone, coupled, and hence, an understanding of how its fracture properties degrade with age is essential. The present study

  5. Mixed-mode fracture of human cortical bone Elizabeth A. Zimmermann a,b

    E-Print Network [OSTI]

    Ritchie, Robert

    Mixed-mode fracture of human cortical bone Elizabeth A. Zimmermann a,b , Maximilien E. Launey Available online 1 July 2009 Keywords: Human cortical bone Mixed-mode fracture Fracture toughness Fracture mechanisms a b s t r a c t Although the mode I (tensile opening) fracture toughness has been the focus

  6. 3D Bone Microarchitecture Modeling and Fracture Risk Department of Computer

    E-Print Network [OSTI]

    Buffalo, State University of New York

    3D Bone Microarchitecture Modeling and Fracture Risk Prediction Hui Li Department of Computer will also rise. It calls for innovative research on understanding of osteoporo- sis and fracture mechanisms-of-the-art probabilistic approach to analyze bone fracture risk factors including demographic attributes and life styles

  7. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 676 (2015) | doi:10.1038/bonekey.2015.43

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number and IBMS Rotterdam, The Netherlands 25­28 April 2015 OP1 (P16) HR-pQCT and DXA Changes in Bone Density

  8. Bone-cement interface micromechanical model under cyclic loading J.A. Sanz-Herrera1, a

    E-Print Network [OSTI]

    Ariza Moreno, Pilar

    Bone-cement interface micromechanical model under cyclic loading J.A. Sanz-Herrera1, a , H descubrimientos s/n 41092 Seville (Spain) a jsanz@us.es, b helgaem@gmail.com, c mpariza@us.es Keywords: Bone-cement of the last XX century. Normally, implant is fixed to bone by means of a polymer material known as bone cement

  9. Estimation of the 3D self-similarity parameter of trabecular bone from its 2D projection

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    of osteoporosis is mainly based on dual energy X-ray absorptiometry which amounts to measuring bone mass

  10. Lectin-mediated effects on bone resorption in vitro: a morphological and functional study

    SciTech Connect (OSTI)

    Popoff, S.N.

    1986-01-01

    Lectins have been used to study the structure and function of a variety of cells and tissues. The authors used 4 different lectins, concanavalin A (con A), wheat germ agglutinin (WGA), soybean agglutinin (SBA) and peanut agglutinin (PNA) as in vitro biological probes to study the osteoclast, a multinucleated bone cell that is widely accepted as the primary effector cell responsible for normal bone resorption. They evaluated the effects of each of these lectins on osteoclastic bone resorbing activity and then examined mechanisms that may be responsible for the activation and/or inhibition of osteoclastic activity. Using con A and hemocyanin, a marker molecule used to visualize cell-bound con A via scanning electron microscopy, they demonstrated that osteoclasts have specific con A binding sites on their cell surface. They conducted a series of /sup 45/Ca bone release assays demonstrating that con A has a dose-dependent biphasic effect on bone resorption; stimulation at low concentrations and inhibition at higher concentrations. The findings suggest that the specificity of lectin binding to cell surface receptors may play an important role in the induction of altered cell function. Recently, cells of the mononuclear phagocyte system have been proposed as surrogates of less readily available osteoclasts. They used a macrophage-devitalized bone culture system to evaluate the effects of con A and SBA on the attachment of macrophages to bone and their subsequent functional activity. The results showed that con A, but not SBA, alters the morphology and function of macrophages on a devitalized bone surface. The results support the hypothesis that certain, specific saccharides regulate the interaction between macrophages and bone.

  11. Relationship between alveolar bone measured by /sup 125/I absorptiometry with analysis of standardized radiographs: 2. Bjorn technique

    SciTech Connect (OSTI)

    Ortman, L.F.; McHenry, K.; Hausmann, E.

    1982-05-01

    The Bjorn technique is widely used in periodontal studies as a standardized measure of alveolar bone. Recent studies have demonstrated the feasibility of using /sup 125/I absorptiometry to measure bone mass. The purpose of this study was to compare /sup 125/I absorptiometry with the Bjorn technique in detecting small sequential losses of alveolary bone. Four periodontal-like defects of incrementally increasing size were produced in alveolar bone in the posterior segment of the maxilla of a human skull. An attempt was made to sequentially reduce the amount of bone in 10% increments until no bone remained, a through and through defect. The bone remaining at each step was measured using /sup 125/I absorptiometry. At each site the /sup 125/I absorptiometry measurements were made at the same location by fixing the photon source to a prefabricated precision-made occlusal splint. This site was just beneath the crest and midway between the borders of two adjacent teeth. Bone loss was also determined by the Bjorn technique. Standardized intraoral films were taken using a custom-fitted acrylic clutch, and bone measurements were made from the root apex to coronal height of the lamina dura. A comparison of the data indicates that: (1) in early bone loss, less than 30%, the Bjorn technique underestimates the amount of loss, and (2) in advanced bone loss, more than 60% the Bjorn technique overestimates it.

  12. Imaging regenerating bone tissue based on neural networks applied to micro-diffraction measurements

    SciTech Connect (OSTI)

    Campi, G.; Pezzotti, G. [Institute of Crystallography, CNR, via Salaria Km 29.300, I-00015, Monterotondo Roma (Italy)] [Institute of Crystallography, CNR, via Salaria Km 29.300, I-00015, Monterotondo Roma (Italy); Fratini, M. [Centro Fermi -Museo Storico della Fisica e Centro Studi e Ricerche 'Enrico Fermi', Roma (Italy)] [Centro Fermi -Museo Storico della Fisica e Centro Studi e Ricerche 'Enrico Fermi', Roma (Italy); Ricci, A. [Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, D-22607 Hamburg (Germany)] [Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, D-22607 Hamburg (Germany); Burghammer, M. [European Synchrotron Radiation Facility, B. P. 220, F-38043 Grenoble Cedex (France)] [European Synchrotron Radiation Facility, B. P. 220, F-38043 Grenoble Cedex (France); Cancedda, R.; Mastrogiacomo, M. [Istituto Nazionale per la Ricerca sul Cancro, and Dipartimento di Medicina Sperimentale dell'Università di Genova and AUO San Martino Istituto Nazionale per la Ricerca sul Cancro, Largo R. Benzi 10, 16132, Genova (Italy)] [Istituto Nazionale per la Ricerca sul Cancro, and Dipartimento di Medicina Sperimentale dell'Università di Genova and AUO San Martino Istituto Nazionale per la Ricerca sul Cancro, Largo R. Benzi 10, 16132, Genova (Italy); Bukreeva, I.; Cedola, A. [Institute for Chemical and Physical Process, CNR, c/o Physics Dep. at Sapienza University, P-le A. Moro 5, 00185, Roma (Italy)] [Institute for Chemical and Physical Process, CNR, c/o Physics Dep. at Sapienza University, P-le A. Moro 5, 00185, Roma (Italy)

    2013-12-16

    We monitored bone regeneration in a tissue engineering approach. To visualize and understand the structural evolution, the samples have been measured by X-ray micro-diffraction. We find that bone tissue regeneration proceeds through a multi-step mechanism, each step providing a specific diffraction signal. The large amount of data have been classified according to their structure and associated to the process they came from combining Neural Networks algorithms with least square pattern analysis. In this way, we obtain spatial maps of the different components of the tissues visualizing the complex kinetic at the base of the bone regeneration.

  13. IBMS BoneKEy. 2009 April;6(4):132-149 http://www.bonekey-ibms.org/cgi/content/full/ibmske;6/4/132

    E-Print Network [OSTI]

    IBMS BoneKEy. 2009 April;6(4):132-149 http://www.bonekey-ibms.org/cgi/content/full/ibmske;6 and osteoporosis, yet uniquely ­ without targeting the resident fat or bone cell. IBMS BoneKEy. 2009 April;6 with diabetes are afflicted with type 2 disease (5-7). Visceral adiposity and #12;IBMS BoneKEy. 2009 April;6

  14. IBMS BoneKEy. 2010 May;7(5):171-181 http://www.bonekey-ibms.org/cgi/content/full/ibmske;7/5/171

    E-Print Network [OSTI]

    Toledo, University of

    IBMS BoneKEy. 2010 May;7(5):171-181 http://www.bonekey-ibms.org/cgi/content/full/ibmske;7/5/171 doi regulation of energy metabolism. IBMS BoneKEy. 2010 May;7(5):171-181. 2010 International Bone & Mineral energy storage and insulin signaling. The dietary abundance of fatty acids increases the #12;IBMS Bone

  15. Mineral status, bone characterisitics, carcass characteristics, and performance of feedlot lambs implanted with zeranol 

    E-Print Network [OSTI]

    Niemann, Dawn Renee

    1998-01-01

    Fifty-four Rambouillet (avg wt, 34.6 kg) wether lambs were used to determine the effects of zeranol of p and N excretion, animal performance, carcass characteristics, and bone characteristics. Lambs were blocked by sire, ...

  16. Finite-Element Analysis of Biting Behavior and Bone Stress in the

    E-Print Network [OSTI]

    Dumont, Elizabeth R.

    about the biomechanical behavior of bones and muscles under controlled experimental condi- tions possess several types of complex teeth that occupy different functional regions of the mouth. In keeping

  17. The effect of moderate alcohol intake on bone mineral density of ovariectomized rats 

    E-Print Network [OSTI]

    Shipley, Debra Lynn

    1997-01-01

    groups had access to rat chow and distilled water ad libitim. Ovariectomized animals had increased weight and decreased femur density and bone volume per total volume. They also had decreased total trubecular area, trabecular area and number as well...

  18. Non-invasive shock wave stimulated periosteum for bone tissue engineering

    E-Print Network [OSTI]

    Kearney, Cathal (Cathal John)

    2011-01-01

    The cambium cells of the periosteum, which are known osteoprogenitor cells, have limited suitability for clinical applications of bone tissue engineering due to their low cell number (2-5 cells thick). Extracorporeal shock ...

  19. Longitudinal ultrasound measurement of the equine third metacarpal bone as a predictor of mechanical testing properties 

    E-Print Network [OSTI]

    Dyer, Stephanie Ann

    1999-01-01

    diagnostic technique to identify the onset of bucked shins. The purpose of this study was to determine if the longitudinal speed of sound as measured by Soundscan 2000[] was an appropriate predictor of bone strength characterized by mechanical testing...

  20. Methods and modeling for the reduced platen compression of cancellous bone in the rodent proximal tibia 

    E-Print Network [OSTI]

    Rogers, William Elliott

    2002-01-01

    This study focused on the reduced platen compression (RPC) test of cancellous bone in the rodent proximal tibia. The objective was to improve methods for this mechanical test, specifically in the areas of specimen location, specimen preparation...

  1. Biochemical markers of bone modeling and remodeling in juvenile racehorses at varying mineral intakes 

    E-Print Network [OSTI]

    Eller, Elena Maria

    2007-09-17

    greater than current NRC recommendations provided a protective effect on the developing skeleton of the young racehorse. Additionally, the biochemical markers used in this study were sensitive enough to track daily changes in bone activity resulting from...

  2. Investigation of bone response to implant materials by electron microscopy and computer simulation

    E-Print Network [OSTI]

    Wang, Hao, 1974-

    2004-01-01

    (cont.) implementation of this scintigraphic method for quantitative studies of osteoblast-mediated mineralization in vitro. A 2-D truss finite element model is used to study the remodeling of trabecular bone. Using strain ...

  3. On the multiscale origins of fracture resistance in human bone and its biological degradation

    SciTech Connect (OSTI)

    Zimmermann, Elizabeth A.; Barth, Holly D.; Ritchie, Robert O.

    2012-03-09

    Akin to other mineralized tissues, human cortical bone can resist deformation and fracture due to the nature of its hierarchical structure, which spans the molecular to macroscopic length-scales. Deformation at the smallest scales, mainly through the composite action of the mineral and collagen, contributes to bone?s strength or intrinsic fracture resistance, while crack-tip shielding mechanisms active on the microstructural scale contribute to the extrinsic fracture resistance once cracking begins. The efficiency with which these structural features can resist fracture at both small and large length-scales becomes severely degraded with such factors as aging, irradiation and disease. Indeed aging and irradiation can cause changes to the cross-link profile at fibrillar length-scales as well as changes at the three orders of magnitude larger scale of the osteonal structures, both of which combine to inhibit the bone's overall resistance to the initiation and growth of cracks.

  4. Analysis of Bone Augmentation With Corticotomy-Facilitated Dental Expansion: A Histologic & Micro-CT Study 

    E-Print Network [OSTI]

    Bare, Britney

    2015-05-08

    The purpose of this study was to evaluate the effect of bone grafting when performed in association with corticotomies. A randomized split-mouth design was utilized in seven adult male beagle dogs. Corticotomies were performed with a piezosurgery...

  5. Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells

    E-Print Network [OSTI]

    Kopesky, Paul Wayne

    Our objective was to test the hypothesis that self-assembling peptide hydrogel scaffolds provide cues that enhance the chondrogenic differentiation of bone marrow stromal cells (BMSCs). BMSCs were encapsulated within two ...

  6. Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions

    DOE Patents [OSTI]

    Srivastava, Suresh C. (Setauket, NY); Meinken, George E. (Middle Island, NY); Mausner, Leonard F. (Stony Brook, NY); Atkins, Harold L. (Setauket, NY)

    1998-12-29

    The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients.

  7. Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions

    DOE Patents [OSTI]

    Srivastava, S.C.; Meinken, G.E.; Mausner, L.F.; Atkins, H.L.

    1998-12-29

    The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients. 5 figs.

  8. Metabolic modeling for the deposition of transuranic nuclides on bone surfaces 

    E-Print Network [OSTI]

    Halter, Donald Anthony

    1997-01-01

    of plutonium throughout the body has still not been developed. It was determined that the majority of these nuclides are deposited on bone surfaces and are removed with a specific biological half-life, [ ],. ICRP Publication 2 addressed the dosimetry...

  9. Inorganic-Organic Shape Memory Polymers and Foams for Bone Defect Repairs 

    E-Print Network [OSTI]

    Zhang, Dawei

    2013-04-16

    The ultimate goal of this research was to develop a “self-fitting” shape memory polymer (SMP) scaffold for the repair of craniomaxillofacial (CMF) bone defects. CMF defects may be caused by trauma, tumor removal or congenital abnormalities...

  10. Development of Osteoinductive, High Porosity PolyHIPEs as Injectable Bone Grafts 

    E-Print Network [OSTI]

    Robinson, Jennifer Lindsey

    2014-08-25

    . Methods to modulate polyHIPE pore architecture, compressive properties, and degradation rates were established. Injectable polyHIPEs with pore sizes ranging from 1- 200 ?m, compressive properties comparable to human cancellous bone, and degradation...

  11. The petrous portion of the human temporal bone: potential for forensic individuation 

    E-Print Network [OSTI]

    Wiersema, Jason Matthew

    2009-06-02

    are threefold: (1) To investigate variability in the shape of the petrous portion of the human temporal bone using two-dimensional morphometric analysis; (2) to evaluate the reliability of the resultant method in forensic identification; and (3) to consider...

  12. Discovery of novel anti-inflammatory proteins inspired by bone marrow mesenchymal stem cell secretions

    E-Print Network [OSTI]

    Milwid, Jack Miles

    2011-01-01

    Bone marrow mesenchymal stem cells (MSCs) may soon become the first FDA-approved stem cell therapy for autoimmune and inflammatory disease. Our lab originally hypothesized that much of the therapeutic activity of MSCs may ...

  13. Mineralization of Decalcified Bone Occurs Under Cell Culture Conditions and Requires Bovine Serum But Not Cells

    E-Print Network [OSTI]

    Price, Paul A.

    on the remineralization of demineralized bone in cell culture medium containing fetal bovine serum. Demineralized newborn to demineralization. Materials and Methods Materials Forty-day-old male rats (Sprague­Dawley-derived) were pur- chased

  14. Classification and volumetric analysis of temporal bone pneumatization using cone beam computed tomography

    E-Print Network [OSTI]

    Terasaki, Mark

    Classification and volumetric analysis of temporal bone pneumatization using cone beam computed Objective. This study performed volumetric analysis and classified different repeated patterns of temporal. Volumetric analysis of the pneumatization was performed using a window thresholding procedure on multiplanar

  15. Factors Affecting the Mechanical Behavior of Bone Subrata Saha, Ph.D.

    E-Print Network [OSTI]

    Gilbert, Robert P.

    Factors Affecting the Mechanical Behavior of Bone by Subrata Saha, Ph.D. Research Professor-mail: subrata.saha@downstate.edu ABSTRACT The load carrying capacity of our skeletal system depends

  16. Calcium balance and bone density in immature horses fed a high protein diet 

    E-Print Network [OSTI]

    Spooner, Holly Sue

    2006-10-30

    Studies in other species indicate high protein diets increase urinary calcium (Ca) excretion and may lead to negative calcium balance and reduced bone density. As overfeeding of protein is commonplace in the horse ...

  17. Bone Marrow Stem Cell Derived Paracrine Factors for Regenerative Medicine: Current Perspectives and Therapeutic Potential

    E-Print Network [OSTI]

    Burdon, Tom J.; Paul, Arghya; Noiseux, Nicolas; Prakash, Satya; Shum-Tim, Dominique

    2011-01-01

    During the past several years, there has been intense research in the field of bone marrow-derived stem cell (BMSC) therapy to facilitate its translation into clinical setting. Although a lot has been accomplished, plenty of challenges lie ahead...

  18. Individual-specific multi-scale finite element simulation of cortical bone of human proximal femur

    SciTech Connect (OSTI)

    Ascenzi, Maria-Grazia, E-mail: mgascenzi@mednet.ucla.edu [UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, Rehabilitation Bldg, Room 22-69, 1000 Veteran Avenue, University of California, Los Angeles, CA 90095 (United States)] [UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, Rehabilitation Bldg, Room 22-69, 1000 Veteran Avenue, University of California, Los Angeles, CA 90095 (United States); Kawas, Neal P., E-mail: nealkawas@ucla.edu [UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, Rehabilitation Bldg, Room 22-69, 1000 Veteran Avenue, University of California, Los Angeles, CA 90095 (United States); Lutz, Andre, E-mail: andre.lutz@hotmail.de [Institute of Biomechanics and Numerical Mechanics, Leibniz University Hannover, 30167 Hannover (Germany)] [Institute of Biomechanics and Numerical Mechanics, Leibniz University Hannover, 30167 Hannover (Germany); Kardas, Dieter, E-mail: kardas@ibnm.uni-hannover.de [ContiTech Vibration Control, Jaedekamp 30 None, 30419 Hannover (Germany)] [ContiTech Vibration Control, Jaedekamp 30 None, 30419 Hannover (Germany); Nackenhorst, Udo, E-mail: nackenhorst@ibnm.uni-hannover.de [Institute of Biomechanics and Numerical Mechanics, Leibniz University Hannover, 30167 Hannover (Germany)] [Institute of Biomechanics and Numerical Mechanics, Leibniz University Hannover, 30167 Hannover (Germany); Keyak, Joyce H., E-mail: jhkeyak@uci.edu [Department of Radiological Sciences, Medical Sciences I, Bldg 811, Room B140, University of California, Irvine, CA 92697-5000 (United States)

    2013-07-01

    We present an innovative method to perform multi-scale finite element analyses of the cortical component of the femur using the individual’s (1) computed tomography scan; and (2) a bone specimen obtained in conjunction with orthopedic surgery. The method enables study of micro-structural characteristics regulating strains and stresses under physiological loading conditions. The analysis of the micro-structural scenarios that cause variation of strain and stress is the first step in understanding the elevated strains and stresses in bone tissue, which are indicative of higher likelihood of micro-crack formation in bone, implicated in consequent remodeling or macroscopic bone fracture. Evidence that micro-structure varies with clinical history and contributes in significant, but poorly understood, ways to bone function, motivates the method’s development, as does need for software tools to investigate relationships between macroscopic loading and micro-structure. Three applications – varying region of interest, bone mineral density, and orientation of collagen type I, illustrate the method. We show, in comparison between physiological loading and simple compression of a patient’s femur, that strains computed at the multi-scale model’s micro-level: (i) differ; and (ii) depend on local collagen-apatite orientation and degree of calcification. Our findings confirm the strain concentration role of osteocyte lacunae, important for mechano-transduction. We hypothesize occurrence of micro-crack formation, leading either to remodeling or macroscopic fracture, when the computed strains exceed the elastic range observed in micro-structural testing.

  19. Strain-guided mineralization in the bone–PDL–cementum complex of a rat periodontium

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Grandfield, Kathryn; Herber, Ralf -Peter; Chen, Ling; Djomehri, Sabra; Tam, Caleb; Lee, Ji -Hyun; Brown, Evan; Woolwine III, Wood R.; Curtis, Don; Ryder, Mark; et al

    2015-04-18

    Objective: The objective of this study was to investigate the effect of mechanical strain by mapping physicochemical properties at periodontal ligament (PDL)–bone and PDL–cementum attachment sites and within the tissues per se. Design: Accentuated mechanical strain was induced by applying a unidirectional force of 0.06 N for 14 days on molars in a rat model. The associated changes in functional space between the tooth and bone, mineral forming and resorbing events at the PDL–bone and PDL–cementum attachment sites were identified by using micro-X-ray computed tomography (micro-XCT), atomic force microscopy (AFM), dynamic histomorphometry, Raman microspectroscopy, and AFM-based nanoindentation technique. Results frommore »these analytical techniques were correlated with histochemical strains specific to low and high molecular weight GAGs, including biglycan, and osteoclast distribution through tartrate resistant acid phosphatase (TRAP) staining. Results: Unique chemical and mechanical qualities including heterogeneous bony fingers with hygroscopic Sharpey's fibers contributing to a higher organic (amide III — 1240 cm?¹) to inorganic (phosphate — 960 cm?¹) ratio, with lower average elastic modulus of 8 GPa versus 12 GPa in unadapted regions were identified. Furthermore, an increased presence of elemental Zn in cement lines and mineralizing fronts of PDL–bone was observed. Adapted regions containing bony fingers exhibited woven bone-like architecture and these regions rich in biglycan (BGN) and bone sialoprotein (BSP) also contained high-molecular weight polysaccharides predominantly at the site of polarized bone growth. Conclusions: From a fundamental science perspective the shift in local properties due to strain amplification at the soft–hard tissue attachment sites is governed by semiautonomous cellular events at the PDL–bone and PDL–cementum sites. Over time, these strain-mediated events can alter the physicochemical properties of tissues per se, and consequently the overall biomechanics of the bone–PDL–tooth complex. From a clinical perspective, the shifts in magnitude and duration of forces on the periodontal ligament can prompt a shift in physiologic mineral apposition in cementum and alveolar bone albeit of an adapted quality owing to the rapid mechanical translation of the tooth.« less

  20. Auger electron spectroscopy for the determination of sex and age related Ca/P ratio at different bone sites

    SciTech Connect (OSTI)

    Balatsoukas, Ioannis; Kourkoumelis, Nikolaos; Tzaphlidou, Margaret [Department of Medical Physics, Medical School, University of Ioannina, Ioannina 45110 (Greece)

    2010-10-15

    The Ca/P ratio of normal cortical and trabecular rat bone was measured by Auger electron spectroscopy (AES). Semiquantitative analysis was carried out using ratio techniques to draw conclusions on how age, sex and bone site affect the relative composition of calcium and phosphorus. Results show that Ca/P ratio is not sex dependent; quite the opposite, bone sites exhibit variations in elemental stoichiometry where femoral sections demonstrate higher Ca/P ratio than rear and front tibias. Age-related changes are more distinct for cortical bone in comparison with the trabecular bone. The latter's Ca/P ratio remains unaffected from all the parameters under study. This study confirms that AES is able to successfully quantify bone mineral main elements when certain critical points, related to the experimental conditions, are addressed effectively.

  1. Salient features in locomotor evolutionary adaptations of proboscideans revealed via the differential scaling of limb long bones

    E-Print Network [OSTI]

    Kokshenev, Valery B

    2009-01-01

    The standard differential scaling of proportions in limb long bones (length against circumference) is applied to a phylogenetically wide sample of the Proboscidea, Elephantidae and the Asian (Elephas maximus) and African elephant (Loxodonta africana). In order to investigate allometric patterns in proboscideans and terrestrial mammals with parasagittal limb kinematics, the computed slopes (slenderness exponents) are compared with published values for mammals and studied within a framework of theoretical models of long bone scaling under gravity and muscle forces. Limb bone allometry in E. maximus and the Elephantidae are congruent with adaptation to bending and/or torsion induced by muscular forces during fast locomotion, as in other mammals, whereas limb bones in L. africana appear adapted for coping with the compressive forces of gravity. Consequently, hindlimb bones are expected to be more compliant than forelimb bones in accordance with in vivo studies on elephant locomotory kinetics and kinematics, and t...

  2. Electron Microscopy and Analytical X-ray Characterization of Compositional and Nanoscale Structural Changes in Fossil Bone

    E-Print Network [OSTI]

    Boatman, Elizabeth

    2012-01-01

    of questions surrounding the diagenesis and fossilization ofthe consequences of diagenesis for that particular feature (on the concept of bone diagenesis and how it relates to

  3. A Bone Density Based Finite Element Study of the Efficacy of Maxillary Protraction Protocols With and Without Mini-Implants

    E-Print Network [OSTI]

    Chu, Howard

    2015-01-01

    accurate location and material properties of the bone andthe dissimilar material properties and capturing the localfinite elements. The material properties of the craniofacial

  4. Synchrotron imaging reveals bone healing and remodelling strategies in extinct and extant vertebrates

    SciTech Connect (OSTI)

    Anne, Jennifer [Univ. of Manchester (United Kingdom); Edwards, Nicholas P. [Univ. of Manchester (United Kingdom); Wogelius, Roy A. [Univ. of Manchester (United Kingdom); Tumarkin-Deratzian, Allison R. [Temple Univ., Philadelphia, PA (United States); Sellers, William I. [Univ. of Manchester (United Kingdom); van Veelen, Arjen [Univ. of Manchester (United Kingdom); Bergmann, Uwe [SLAC National Accelerator Laboratory, Menlo Park, CA (United States); Sokaras, Dimosthenis [SLAC National Accelerator Laboratory, Menlo Park, CA (United States); Alonso-Mori, Roberto [SLAC National Accelerator Laboratory, Menlo Park, CA (United States); Ignatyev, Konstantin [Diamond Light Source (United Kingdom); Egerton, Victoria M. [Univ. of Manchester (United Kingdom); Manning, Phillip L. [Univ. of Manchester (United Kingdom)

    2014-04-23

    Current understanding of bone healing and remodelling strategies in vertebrates has traditionally relied on morphological observations through the histological analysis of thin sections. However, chemical analysis may also be used in such interpretations, as different elements are known to be absorbed and used by bone for different physiological purposes such as growth and healing. These chemical signatures are beyond the detection limit of most laboratory-based analytical techniques (e.g. scanning electron microscopy). However, synchrotron rapid scanning–X-ray fluorescence (SRS–XRF) is an elemental mapping technique that uniquely combines high sensitivity (ppm), excellent sample resolution (20–100 ?m) and the ability to scan large specimens (decimetre scale) approximately 3000 times faster than other mapping techniques. Here, we use SRS–XRF combined with microfocus elemental mapping (2–20 ?m) to determine the distribution and concentration of trace elements within pathological and normal bone of both extant and extinct archosaurs (Cathartes aura and Allosaurus fragilis). Results reveal discrete chemical inventories within different bone tissue types and preservation modes. Chemical inventories also revealed detail of histological features not observable in thin section, including fine structures within the interface between pathological and normal bone as well as woven texture within pathological tissue.

  5. Enrichment for CFU-C from murine and human bone marrow using soybean agglutinin

    SciTech Connect (OSTI)

    Reisner, Y.; Kapoor, N.; Hodes, M.Z.; O'Reilly, R.J.; Good, R.A.

    1982-02-01

    Mouse bone marrow and spleen cells agglutinated by soybean agglutinin (SBA) or peanut agglutinin (PNA) were previously shown to be enriched for spleen colony-forming cells (CFU-S) and sufficiently depleted of graft-versus-host reaction producing cells to allow hematologic reconstitution of lethally irradiated allogeneic recipient mice. A similar enrichment for cells capable of forming colonies in soft agar culture (CFU-C) has now been found in the SBA-agglutinated fraction of mouse bone marrow cells, in contrast to the finding that in human bone marrow the majority of the CFU-C are in the fraction not agglutinated by SBA. Cytofluorometric studies with fluorescein-labeled SBA (FITC-SBA) revealed that the majority of both mouse and human bone marrow cells bind the lectin. Experiments mixing the human marrow fractions separated by SBA reveal that true enrichment for CFU-C is achieved in the unagglutinated fraction, as opposed to a possible depletion of a suppressor cell population. Granulocytic, monocytic, and mixed cell colonies were all enriched in the SBA-unagglutinated cell fraction from human bone marrow.

  6. Synchrotron imaging reveals bone healing and remodelling strategies in extinct and extant vertebrates

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Anne, Jennifer; Edwards, Nicholas P.; Wogelius, Roy A.; Tumarkin-Deratzian, Allison R.; Sellers, William I.; van Veelen, Arjen; Bergmann, Uwe; Sokaras, Dimosthenis; Alonso-Mori, Roberto; Ignatyev, Konstantin; et al

    2014-04-23

    Current understanding of bone healing and remodelling strategies in vertebrates has traditionally relied on morphological observations through the histological analysis of thin sections. However, chemical analysis may also be used in such interpretations, as different elements are known to be absorbed and used by bone for different physiological purposes such as growth and healing. These chemical signatures are beyond the detection limit of most laboratory-based analytical techniques (e.g. scanning electron microscopy). However, synchrotron rapid scanning–X-ray fluorescence (SRS–XRF) is an elemental mapping technique that uniquely combines high sensitivity (ppm), excellent sample resolution (20–100 ?m) and the ability to scan large specimensmore »(decimetre scale) approximately 3000 times faster than other mapping techniques. Here, we use SRS–XRF combined with microfocus elemental mapping (2–20 ?m) to determine the distribution and concentration of trace elements within pathological and normal bone of both extant and extinct archosaurs (Cathartes aura and Allosaurus fragilis). Results reveal discrete chemical inventories within different bone tissue types and preservation modes. Chemical inventories also revealed detail of histological features not observable in thin section, including fine structures within the interface between pathological and normal bone as well as woven texture within pathological tissue.« less

  7. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 680 (2015) | doi:10.1038/bonekey.2015.47

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number PARALLEL PROGRAMME The 4th Joint Meeting of ECTS and IBMS Rotterdam, The Netherlands 25­28 April 2015 CABS

  8. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 677 (2015) | doi:10.1038/bonekey.2015.44

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number Joint Meeting of ECTS and IBMS Rotterdam, The Netherlands 25­28 April 2015 OC1.1 Wnt16 Promotes

  9. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 684 (2015) | doi:10.1038/bonekey.2015.52

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number Meeting of ECTS and IBMS Rotterdam, The Netherlands 25­28 April 2015 CECR 1 Which Came First: Parathyroid

  10. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 674 (2015) | doi:10.1038/bonekey.2015.41

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number POSTERS - CABS The 4th Joint Meeting of ECTS and IBMS Rotterdam, The Netherlands 25­28 April 2015 CABS OP1

  11. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS Citation: IBMS BoneKEy 3, Article number: 673 (2015) | doi:10.1038/bonekey.2015.40

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS Citation: IBMS BoneKEy 3, Article number.86 [95% CI=0.78-0.94]) and THR POSTER PRESENTATIONS The 4th Joint Meeting of ECTS and IBMS Rotterdam

  12. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 682 (2015) | doi:10.1038/bonekey.2015.50

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number of ECTS and IBMS Rotterdam, The Netherlands 25­28 April 2015 D1.1 Abstract not available D1.2 This House

  13. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 681 (2015) | doi:10.1038/bonekey.2015.49

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number reserved 1940-8692/15 www.nature.com/bonekey WORKSHOP ABSTRACTS The 4th Joint Meeting of ECTS and IBMS

  14. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 683 (2015) | doi:10.1038/bonekey.2015.51

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number ABSTRACTS The 4th Joint Meeting of ECTS and IBMS Rotterdam, The Netherlands 25­28 April 2015 S1.1 Abstract

  15. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 678 (2015) | doi:10.1038/bonekey.2015.45

    E-Print Network [OSTI]

    Cai, Long

    2015-01-01

    IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article numberth Joint Meeting of ECTS and IBMS Rotterdam, The Netherlands 25­28 April 2015 HT1 High Serum Levels

  16. Phenotypic characterization of early events of thymus repopulation in radiation bone marrow chimeras

    SciTech Connect (OSTI)

    Sharrow, S.O.; Singer, A.; Hammerling, U.; Mathieson, B.J.

    1983-04-01

    The phenotype of murine thymocytes repopulating the thymus of radiation bone marrow chimeras shortly after irradiation and bone marrow reconstitution was analyzed by immunofluorescence and flow microfluorometry. Thymuses in these chimeras, while essentially devoid of lymphoid cells at day 7, were repopulated by days 10 to 12 after irradiation. It was found that this initial repopulation arose from a radioresistant intrathymic precursor that expanded to an almost complete complement of host-type thymocytes. However, these host-derived thymocytes were unusual in that they were relatively deficient in Lyt 1+2- and peanut agglutinin ''dull'' cells as compared with normal thymocytes. Donor bone-marrow-derived cells first appeared in the irradiated chimeric thymuses between days 12 and 15 after irradiation and bone marrow transfer. By day 19, chimeric thymuses contained more than 98% donor cells. This course was identical for three chimeric combinations, each made across different genetic barriers. In contrast to the cells that populate the fetal thymus during normal ontogeny, the first donor bone-marrow-derived cells that can be detected within the irradiated chimeric thymuses already expressed phenotypically normal adult T cell subpopulations in that they contained significant numbers both of Lyt 1+2- and of Lyt 1+2+ thymocytes. Thus, the Lyt phenotype of donor cells that initially repopulate an adult thymus after irradiation is markedly different from the Lyt phenotype of cells that initially populate the fetal thymus. The differences between adult and fetal thymic development that are observed in radiation bone marrow chimeras may be important in our understanding of T cell differentiation in these animals.

  17. A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions.

    E-Print Network [OSTI]

    2011-01-01

    cancer [4,17-19]. Direct injection of prostate can- cer4,20,21]. However, direct injection models into the bone-24]. Page 2 of 13 Direct bone-injection murine xenograft

  18. Development of a three-dimensional in vitro model to study the effect of vitamin D on bone metastatic breast cancer

    E-Print Network [OSTI]

    Li, Danda

    2011-08-31

    Breast cancer has a high prevalence among women and most patients suffer from metastasis to bone. The mechanisms involved in breast cancer bone metastasis are poorly understood. Three-dimensional (3D) tissue culture systems are becoming a focus...

  19. Hierarchical interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales

    E-Print Network [OSTI]

    Lipman, Everett A.

    to its biomedical significance, bone has been used as a model for many artificial bio-ceramic composites [10,11]. In many of these artificial composites, a combina- tion of a soft polymer matrix reinforcedHierarchical interconnections in the nano-composite material bone: Fibrillar cross-links resist

  20. SYMPOSIUM: SEX DIFFERENCES IN MUSCULOSKELETAL DISEASE AND SCIENCE b-Ecdysone Augments Peak Bone Mass in Mice of Both Sexes

    E-Print Network [OSTI]

    Ritchie, Robert

    SYMPOSIUM: SEX DIFFERENCES IN MUSCULOSKELETAL DISEASE AND SCIENCE b-Ecdysone Augments Peak Bone Mass in Mice of Both Sexes Weiwei Dai PhD, HongLiang Zhang MD, PhD, Zhendong A. Zhong PhD, Li Jiang MD to investigate sex differences in terms of bone development and structure after bEcd administration. Methods Two

  1. Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone

    E-Print Network [OSTI]

    Ritchie, Robert

    each hier- archical structural level contributes to its strength, ductility and toughness-ray exposures up to 630 kGy. Macroscopically, bone strength, ductility and fracture resistance are seen August 2011 Keywords: Human cortical bone Deformation Toughness X-ray diffraction Tomography Collagen a b

  2. Prevention of Postmenopausal Bone Loss by a Low-Magnitude, High-Frequency Mechanical Stimuli: A Clinical Trial Assessing Compliance,

    E-Print Network [OSTI]

    words: osteoporosis, anabolic, mechanical loading, vibration, low-level, frequency, osteogenic, musclePrevention of Postmenopausal Bone Loss by a Low-Magnitude, High- Frequency Mechanical Stimuli) of a low-level (0.2g, 30 Hz) vibration applied during quiet standing can effectively inhibit bone loss

  3. A Serum Factor that Recalcifies Demineralized Bone Is Conserved in Bony Fish and Sharks but Is Not Found in Invertebrates

    E-Print Network [OSTI]

    Price, Paul A.

    A Serum Factor that Recalcifies Demineralized Bone Is Conserved in Bony Fish and Sharks fish -- Cartilagi- nous fish We recently showed that the type I collagen matrix of demineralized bone and phosphate into demineralized rat tibias ceases after several weeks of incubation in suc- cessive volumes

  4. The significance of crack-resistance curves to the mixed-mode fracture toughness of human cortical bone

    E-Print Network [OSTI]

    Ritchie, Robert

    The significance of crack-resistance curves to the mixed-mode fracture toughness of human cortical cortical bone Mixed-mode fracture Fracture toughness Crack-growth resistance curve a b s t r a c t The majority of fracture mechanics studies on the toughness of bone have been performed under tensile loading

  5. COMBINING CLASSIFIERS FOR BONE FRACTURE DETECTION IN X-RAY IMAGES Vineta Lai Fun Lum, Wee Kheng Leow, Ying Chen,

    E-Print Network [OSTI]

    Leow, Wee Kheng

    COMBINING CLASSIFIERS FOR BONE FRACTURE DETECTION IN X-RAY IMAGES Vineta Lai Fun Lum, Wee Kheng combination methods ap- plied to the detection of bone fractures in x-ray images. Test results show, only about 12% of them contained fractured femurs. For radius images, about 30% of 145 consecu- tive

  6. Methods for identifying cancellous bone specimen location and size for the Reduced Platen Compression Test 

    E-Print Network [OSTI]

    Cowen, Kyle Ray

    2013-02-22

    the locatron of the RPt: 'lest specimen within the femur. In previous tests, SigmaScan/Image was used to measure thc distance from the distal end of the femur to the drstal extent of the epiphyseal growth plate. The distance was averaged for the entire tesi... Measurement of Bone: A Tutorial. Bone. 14, 595-608, VITA Ky!e Ray Cowen was born tn Amarillo, Texas on February 17, 197'7 to Alvin and Carol Cowen. Kyle is the youngest of two children, the oldest bc!ng his sister Kans who was burr. c:! Decemder?, 1973...

  7. Feeding Bone Meal to Range Cattle on the Coastal Plains of Texas : Preliminary Report. 

    E-Print Network [OSTI]

    Schmidt, H.

    1926-01-01

    .. Chref I FAR L. B. G. v. * *T. **J. M AND RANCH ECONOMICS: P GABBARD b1 S Chief YOUNGBLOO~, M.'s., Ph. D., Farm d . Ranch Economrst. , L. CRAWFORD, M.-S., Research Mark& Specralrst L. CORY, M. S.. Grazing Research Botanil L. GASTON, JR., B...~on with U. S. Department.of Agriculture ***In cooperation with the School of Agriculture. SYNOPSIS X is Bulletin reports results obtained by feeding bone meal and salt mixtures and finely ground rock phosphate mixed with bone meal and salt to cattle...

  8. APPLICATIONS OF ALGEBRAIC MULTIGRID TO LARGE-SCALE FINITE ELEMENT ANALYSIS OF WHOLE BONE MICRO-MECHANICS ON THE IBM SP

    E-Print Network [OSTI]

    California at Berkeley, University of

    APPLICATIONS OF ALGEBRAIC MULTIGRID TO LARGE-SCALE FINITE ELEMENT ANALYSIS OF WHOLE BONE MICRO,5 Abstract. Accurate micro-finite element analyses of whole bones require the solution of large sets architectures. Key words. multigrid, trabecular bone, human vertebral body, finite element method, massively

  9. Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis

    E-Print Network [OSTI]

    Toledo, University of

    used TZDs (pioglitazone and rosiglita- zone) by using combinational therapy with approved antiosteoporotic drugs, or by using lower doses of TZDs in combination with other antidiabetic therapy. We also healing in T2DM patients on TZD therapy. Keywords Diabetes . Thiazolidinediones . Bone . Osteoporosis

  10. Effect of cryo-induced microcracks on microindentation of hydrated cortical bone tissue

    E-Print Network [OSTI]

    Qin, Qinghua

    tissue was plastic deformation, not brittle fracture. © 2009 Elsevier Inc. All rights reserved. Keywords 1. Introduction Bone contains approximately 60% ceramic nanoparticles of inorganic carbonated hydroxyapatite, 10% water and about 30% polymer matrix of organic and mineralized collagen fibers by weight [1

  11. Kidney, liver and bone cadmium content in the western sandpiper in relation to migration

    E-Print Network [OSTI]

    Kidney, liver and bone cadmium content in the western sandpiper in relation to migration C. N. Mc the Pacific Coast, at stopover sites as the birds migrate north to Alaska and south to Panama. This study ingestion of metal bearing sediments.1 These sediment-dwelling organisms in turn are primary food sources

  12. Stability and Three-Dimensional Analysis of Bone Formation in Longitudinally Fluted Miniscrew Implants 

    E-Print Network [OSTI]

    Truong, An Van

    2014-04-22

    The purpose of the present study is to evaluate the effects of longitudinal flutes on mini-screw implant (MSI) bone healing and stability. Using 11 skeletally mature New Zealand White rabbits, 33 longitudinally fluted and 33 non-fluted MSIs were...

  13. Patient-Specific FE Analyses of Metatarsal Bones with1 Inhomogeneous Isotropic Material Properties2

    E-Print Network [OSTI]

    Yosibash, Zohar

    research and clinical practice, especially when associated with the9 correction of Hallux Valgus. Verified to Hallux14 Valgus correction are then drilled in the bones, which are then reloaded until15 fracture on the mechanical response so to optimize the outcome of the Hallux Valgus27 correction.28 This study further

  14. Microfluidic purification and analysis of hematopoietic stem cells from bone Romana Schirhagl,a

    E-Print Network [OSTI]

    Zare, Richard N.

    Microfluidic purification and analysis of hematopoietic stem cells from bone marrow Romana to separate them from a whole-marrow sample. A microfluidic device was fabricated using an integrated membrane are restricted by the limited availability of stem cell sources.2,3 We believe that microfluidics can be used

  15. JOURNAL OF BONE AND MINERAL RESEARCH Volume 7, Number 12, 1992

    E-Print Network [OSTI]

    Chuong, Cheng-Ming

    JOURNAL OF BONE AND MINERAL RESEARCH Volume 7, Number 12, 1992 Mary Ann Liebert, Inc., Publishers behavior and molecular ex- pression before it finally becomes a mineralizing osteocyte. The progression, extracellular maturation, and mineralization -are identified. (3.4) Many molecules functioning as growth fac

  16. Elemental concentrations in bones from an ancient Egyptian mummy and from a recent man

    SciTech Connect (OSTI)

    Cholewa, M.; Kwiatek, W.M.; Jones, K.W.; Schidlovsky, G.; Paschoa, A.S.; Miller, S.C.; Pecotte, J.

    1986-06-01

    Differences in elemental concentrations in bones taken from an ancient Egyptian mummy and a contemporary man were investigated by using proton induced x-ray emission (PIXE) in combination with Rutherford backscattering (RBS). Remarkable differences were noticed in the Fe/Ca and Pb/Ca relative concentrations, which were consistently higher in the contemporary man. 5 refs., 2 figs., 2 tabs.

  17. School of Architecture, Design and the Built Environment Project Title: Artificial bone for prosthetic hip joints

    E-Print Network [OSTI]

    Evans, Paul

    formation by the Additive Manufacturing (AM) direct printing process. The artificial bone must and the development of new additive manufacturing techniques for medical devices. The group has active links and structural gradients into the prosthesis. It is envisioned this could involve the use of additively

  18. The basic tenet of skeletochronology is that bone growth is cyclic and has an

    E-Print Network [OSTI]

    United States. and amphibians include double (Chin- samy et al., 1995; El Mouden et al., 1997; Guarino et's ridley sea turtles from a comparison of death date and amount of bone growth following the comple- tion-at-age and growth rates can be estimated from dimen- sions of early growth marks. These results validate

  19. Corrigendum Mechanics of limb bone loading during terrestrial locomotion in river cooter turtles

    E-Print Network [OSTI]

    Blob, Richard W.

    bending and shear stress and of safety factors in bending were unaffected by this error, but the mean and conclusions of the original paper remain unchanged. REFERENCES Biewener, A. A. and Dial, K. P. (1995). In vivo. concinna Bending Torsion Bone N Yield stress (MPa) Safety factor mean N Yield stress (MPa) Safety factor

  20. Mitigating Disuse Bone Loss: Role of Resistance Exercise and Beta-Adrenergic Signaling 

    E-Print Network [OSTI]

    Swift, Joshua Michael

    2011-08-08

    . Recent data gathered from crew members on the International Space Station (ISS) illustrates the significant losses of bone mineral density (BMD) and geometry of the femoral neck (15). Dual-energy x-ray absorptiometry (DXA) and QCT scans were taken...

  1. A 3D Statistical Shape Model Of The Pelvic Bone For Segmentation

    E-Print Network [OSTI]

    Andrzejak, Artur

    patient models from 3D image data. Within the setting of a hybrid system (applicator plus MR tomograph. Left: hybrid system (MRT plus applicator), Right: MRT slice image from the abdomen with pelvic bone. 1 on heating up affected tissue compartments to temperatures above 42 degree Celsius without damaging

  2. Trabecular Bone Structure and Cellular Morphology in the Primate Craniofacial Skeleton 

    E-Print Network [OSTI]

    Pryor, Leslie Claire

    2015-08-14

    BONE STRUCTURE AND CELLULAR MORPHOLOGY IN THE PRIMATE CRANIOFACIAL SKELETON A Dissertation by LESLIE CLAIRE PRYOR Submitted to the Office of Graduate and Professional Studies of Texas A&M University in partial fulfillment... Emet Schneiderman David Strait Head of Department, Paul C. Dechow August 2015 Major Subject: Biomedical Sciences Copyright 2015 Leslie Claire Pryor ii ABSTRACT The primate craniofacial skeleton is complex...

  3. On Smoothing Surfaces in Voxel Based Finite Element Analysis of Trabecular Bone

    E-Print Network [OSTI]

    Frey, Pascal

    On Smoothing Surfaces in Voxel Based Finite Element Analysis of Trabecular Bone Peter Arbenz on complicated domains composed of often hundreds of millions of voxel elements. The finite element analysis finite element (FE) analysis. The approach based on the FE analysis leads to linear systems of equations

  4. Mechanical regulation of signaling pathways in bone, William R. Thompson a,

    E-Print Network [OSTI]

    , cyclooxygenase 2; LMMS, low magnitude mechanical stimulation; LIV, low intensity vibration; CT, micro compReview Mechanical regulation of signaling pathways in bone, William R. Thompson a, , Clinton T A wide range of cell types depend on mechanically induced signals to enable appropriate physiological re

  5. Sex Differences in Long Bone Fatigue Using a Rat Model Luisa D. Moreno,1

    E-Print Network [OSTI]

    Waldman, Stephen D.

    response to fatigue, we also determined the creep that occurred during the fatigue test. From the creep progress (Fig. 1). Caler and Carter32 studied cortical bone creep behavior during fatigue testing. When adaptation. From these results, we hypothesized that creep was the underlying mechanism that accounted

  6. The consequence of late-onset alcohol abuse in aged bone: a histomorhometric analysis 

    E-Print Network [OSTI]

    Barker, Lisa Setchfield

    2000-01-01

    The objective of this experiment was to examine the effect of late-onset alcohol abuse on aged bone using the rat model. Thirty female Fischer 344 rats were separated by weights into one of four groups: baseline, alcohol-fed, pair-fed, and pellet...

  7. Biomaterials 27 (2006) 20952113 Fracture length scales in human cortical bone

    E-Print Network [OSTI]

    Ritchie, Robert

    2006-01-01

    Biomaterials 27 (2006) 2095­2113 Fracture length scales in human cortical bone: The necessity of nonlinear fracture models Q.D. Yanga,Ã, Brian N. Coxa , Ravi K. Nallab , R.O. Ritchieb a Rockwell Scientific; accepted 26 September 2005 Available online 4 November 2005 Abstract Recently published data for fracture

  8. HEMATOPOIESIS Soluble factor cross-talk between human bone marrow-derived hematopoietic and

    E-Print Network [OSTI]

    Zandstra, Peter W.

    HEMATOPOIESIS Soluble factor cross-talk between human bone marrow-derived hematopoietic BM-derived progenitors and the balance between these compartments. Factorial experiments demonstrated45 ) and nonhematopoietic (CD45 ) cells, as well as their derivatives. Kinetic tracking of IL-3

  9. SU-E-J-212: Identifying Bones From MRI: A Dictionary Learnign and Sparse Regression Approach

    SciTech Connect (OSTI)

    Ruan, D; Yang, Y; Cao, M; Hu, P; Low, D [UCLA, Los Angeles, CA (United States)

    2014-06-01

    Purpose: To develop an efficient and robust scheme to identify bony anatomy based on MRI-only simulation images. Methods: MRI offers important soft tissue contrast and functional information, yet its lack of correlation to electron-density has placed it as an auxiliary modality to CT in radiotherapy simulation and adaptation. An effective scheme to identify bony anatomy is an important first step towards MR-only simulation/treatment paradigm and would satisfy most practical purposes. We utilize a UTE acquisition sequence to achieve visibility of the bone. By contrast to manual + bulk or registration-to identify bones, we propose a novel learning-based approach for improved robustness to MR artefacts and environmental changes. Specifically, local information is encoded with MR image patch, and the corresponding label is extracted (during training) from simulation CT aligned to the UTE. Within each class (bone vs. nonbone), an overcomplete dictionary is learned so that typical patches within the proper class can be represented as a sparse combination of the dictionary entries. For testing, an acquired UTE-MRI is divided to patches using a sliding scheme, where each patch is sparsely regressed against both bone and nonbone dictionaries, and subsequently claimed to be associated with the class with the smaller residual. Results: The proposed method has been applied to the pilot site of brain imaging and it has showed general good performance, with dice similarity coefficient of greater than 0.9 in a crossvalidation study using 4 datasets. Importantly, it is robust towards consistent foreign objects (e.g., headset) and the artefacts relates to Gibbs and field heterogeneity. Conclusion: A learning perspective has been developed for inferring bone structures based on UTE MRI. The imaging setting is subject to minimal motion effects and the post-processing is efficient. The improved efficiency and robustness enables a first translation to MR-only routine. The scheme generalizes to multiple tissue classes.

  10. Lung cancer-derived Dickkopf1 is associated with bone metastasis and the mechanism involves the inhibition of osteoblast differentiation

    SciTech Connect (OSTI)

    Chu, Tianqing; Teng, Jiajun; Jiang, Liyan; Zhong, Hua; Han, Baohui

    2014-01-17

    Highlights: •DKK1 level was associated with NSCLC bone metastases. •Lung tumor cells derived DKK1 inhibited osteoblast differentiation. •Lung tumor cells derived DKK1 modulates ?-catenin and RUNX2. -- Abstract: Wnt/?-catenin signaling and Dickkopf1 (DKK1) play important roles in the progression of lung cancer, which preferably metastasizes to skeleton. But the role of them in bone dissemination is poorly understood. This study aims to define the role of DKK1 in lung cancer bone metastases and investigate the underlying mechanism. Our results demonstrated that DKK1 over-expression was a frequent event in non-small-cell lung cancer (NSCLC) blood samples, and serous DKK1 level was much higher in bone metastatic NSCLC compared to non-bone metastatic NSCLC. We also found that conditioned medium from DKK1 over-expressing lung cancer cells inhibited the differentiation of osteoblast, determined by alkaline phosphatase activity and osteocalcin secretion, whereas the conditioned medium from DKK1 silencing lung cancer cells exhibited the opposite effects. Mechanistically, DKK1 reduced the level of ?-catenin and RUNX2, as well as inhibiting the nuclear translocation of ?-catenin. Taken together, these results suggested that lung cancer-produced DKK1 may be an important mechanistic link between NSCLC and bone metastases, and targeting DKK1 may be an effective method to treat bone metastase of NSCLC.

  11. Photoacoustic and ultrasonic probing of bone density in ex-vivo animal tissues The purpose of the proposed research is to develop fundamental physical, instrumental and biological aspects of two novel

    E-Print Network [OSTI]

    Sun, Yu

    (photoacoustic probe) of bones through skin layers under various degrees of demineralization and porosity (void

  12. Potential commercial application of a bi-layer bone-ligament regeneration scaffold to anterior cruciate ligament replacement

    E-Print Network [OSTI]

    Li, Jessica C. (Jessica Ching-Yi)

    2006-01-01

    A business model was created in order to explore the commercial application of a bi-layer bone-ligament scaffold to the treatment of torn anterior cruciate ligaments (ACL) requiring replacement. The two main keys in producing ...

  13. Regional geologic characterization of the Second Bone Spring Sandstone, Delaware basin, Lea and Eddy Counties, New Mexico 

    E-Print Network [OSTI]

    Downing, Amanda Beth

    2001-01-01

    The Bone Spring Formation is a series of interbedded siliciclastics and carbonates that were deposited in the Delaware basin during the Leonardian (Early Permian). It consists of the First, Second and Third Carbonate and the First, Second and Third...

  14. Effect of dietary calcium and phosphorus levels on performance and bone development of large-framed developing boars 

    E-Print Network [OSTI]

    Robinson, Robert Glen

    1975-01-01

    EFFECT OF DIETARY CALCIUM AND PHOSPHORUS LEVELS ON PERFORMANCE AND BONE DEVELOPMENT OF LARGE-FRAMED DEVELOPING BOARS A Thesis by ROBERT GLEN ROBINSON Submitted to the Graduate College of Texas AQ4 University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1975 Major Subject. : Animal Science EFFECT OF DIETARY CALCIUM AND PHOSPHORUS LEVELS ON PERFORMANCE AND BONE DEVELOPMENT OF LARGE-~ DEVELOPING BOARS A Thesis by ROBERT GLEN ROBINSON Approved...

  15. The relationship of the long bones of the thoracic and pelvic limbs as indicators of muscling in the beef carcass 

    E-Print Network [OSTI]

    Orts, Frank A

    1959-01-01

    and content hys hsirman of Ccmmitt Head of Department, August, 1959 Ths author is grateful for the interest and help of the staff ueabers of the Departasnts of tuinal Husbandry and Genetics, Sinoere gratitude is expressed to Dr. G. T. King, Assistant... Measurements . ~ 35 19, Group 5I Gross Simple Coefficients of Correlation Between Trimmed Bone Lengths and Carouse Measurements ~ . 36 20. Group 6I Gross Simple Coefficients of Correlation Between Trimmed Bone Lengths and Carcass Measurements . . 36 21...

  16. Intra-arterial Autologous Bone Marrow Cell Transplantation in a Patient with Upper-extremity Critical Limb Ischemia

    SciTech Connect (OSTI)

    Madaric, Juraj; Klepanec, Andrej; Mistrik, Martin; Altaner, Cestmir; Vulev, Ivan

    2013-04-15

    Induction of therapeutic angiogenesis by autologous bone marrow mononuclear cell transplantation has been identified as a potential new option in patients with advanced lower-limb ischemia. There is little evidence of the benefit of intra-arterial cell application in upper-limb critical ischemia. We describe a patient with upper-extremity critical limb ischemia with digital gangrene resulting from hypothenar hammer syndrome successfully treated by intra-arterial autologous bone marrow mononuclear cell transplantation.

  17. Effect of irradiation on bone remodelling and the structural integrity of the vertebral column. Doctoral thesis

    SciTech Connect (OSTI)

    Swenson, K.N.

    1990-01-01

    The effects of therapeutic levels of radiation on the axial properties of the primate vertebral column were studied. Seven male rhesus monkeys (Macaca mulatta) were irradiated with a single does of 1300 cGy to the specific lumbar vertebrae of L2, L3, and L4. Three additional animals served as controls. Radiographs were taken before the radiation treatment and just prior to sacrifice to determine density changes in the bone. The animal subjects were sacrificed 105 days following the radiation exposure. Biomechanical testing was completed on lumbar levels 2 and 3 to identify changes in strength characteristics following radiation treatment. Histomorphometric analysis of lumbar vertebrae level 4 was completed to identify volume and surface density changes as well as cellular changes. Tetracycline, dicarbomethylaminomethyl fluorescein (DCAF), and xylenol orange were used as bone labeling agents to aid in the histomorphometry and to obtain dynamic parameter changes.

  18. SU-E-J-250: A Methodology for Active Bone Marrow Protection for Cervical Cancer Intensity-Modulated Radiotherapy Using 18F-FLT PET/CT Image

    SciTech Connect (OSTI)

    Ma, C; Yin, Y

    2014-06-01

    Purpose: The purpose of this study was to compare a radiation therapy treatment planning that would spare active bone marrow and whole pelvic bone marrow using 18F FLT PET/CT image. Methods: We have developed an IMRT planning methodology to incorporate functional PET imaging using 18F FLT/CT scans. Plans were generated for two cervical cancer patients, where pelvicactive bone marrow region was incorporated as avoidance regions based on the range: SUV>2., another region was whole pelvic bone marrow. Dose objectives were set to reduce the volume of active bone marrow and whole bone marraw. The volumes of received 10 (V10) and 20 (V20) Gy for active bone marrow were evaluated. Results: Active bone marrow regions identified by 18F FLT with an SUV>2 represented an average of 48.0% of the total osseous pelvis for the two cases studied. Improved dose volume histograms for identified bone marrow SUV volumes and decreases in V10(average 18%), and V20(average 14%) were achieved without clinically significant changes to PTV or OAR doses. Conclusion: Incorporation of 18F FLT/CT PET in IMRT planning provides a methodology to reduce radiation dose to active bone marrow without compromising PTV or OAR dose objectives in cervical cancer.

  19. Acculturation in the Upper Middle Missouri Valley as Reflected in Modified Bone Assemblages

    E-Print Network [OSTI]

    Weston, Timothy

    1986-05-01

    Gliders 207 Piercing Tools (Awls ) • 20 Tubes/Beads 208 Expedient Tools 211 Other Tool Categories 214 Horn Core/Frontal Tools. 21 Fleshing Tools 21 Cancellous Tools 7 Fish Hooks 8 Polished Fragments • • 221 Ochre-Stained Bone 22 Ornaments . • 22... Components 251 Big Hidatsa Original Components 4 Condensed Components 25 Lower Hidatsa 257 Sakakawea 260 Big Hidatsa 3 Other Measures of Change •. •. 266 Metal/Stone Modification 26 Predominant Method of Manufacture.... .. 271 Combined Site Assemblages...

  20. Automatic detection of bone fragments in poultry using multi-energy x-rays

    DOE Patents [OSTI]

    Gleason, Shaun S. (Knoxville, TN); Paulus, Michael J. (Knoxville, TN); Mullens, James A. (Knoxville, TN)

    2002-04-09

    At least two linear arrays of x-ray detectors are placed below a conveyor belt in a poultry processing plant. Multiple-energy x-ray sources illuminate the poultry and are detected by the detectors. Laser profilometry is used to measure the poultry thickness as the x-ray data is acquired. The detector readout is processed in real time to detect the presence of small highly attenuating fragments in the poultry, i.e., bone, metal, and cartilage.

  1. cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction

    SciTech Connect (OSTI)

    Son, Jieun; Lee, Jong-Ho; Kim, Ha-Neui; Ha, Hyunil Lee, Zang Hee

    2010-07-23

    Research highlights: {yields} CREB is highly expressed in advanced breast cancer cells. {yields} Tumor-related factors such as TGF-{beta} further elevate CREB expression. {yields} CREB upregulation stimulates metastatic potential of breast cancer cells. {yields} CREB signaling is required for breast cancer-induced bone destruction. -- Abstract: cAMP-response-element-binding protein (CREB) signaling has been reported to be associated with cancer development and poor clinical outcome in various types of cancer. However, it remains to be elucidated whether CREB is involved in breast cancer development and osteotropism. Here, we found that metastatic MDA-MB-231 breast cancer cells exhibited higher CREB expression than did non-metastatic MCF-7 cells and that CREB expression was further increased by several soluble factors linked to cancer progression, such as IL-1, IGF-1, and TGF-{beta}. Using wild-type CREB and a dominant-negative form (K-CREB), we found that CREB signaling positively regulated the proliferation, migration, and invasion of MDA-MB-231 cells. In addition, K-CREB prevented MDA-MB-231 cell-induced osteolytic lesions in a mouse model of cancer metastasis. Furthermore, CREB signaling in cancer cells regulated the gene expression of PTHrP, MMPs, and OPG, which are closely involved in cancer metastasis and bone destruction. These results indicate that breast cancer cells acquire CREB overexpression during their development and that this CREB upregulation plays an important role in multiple steps of breast cancer bone metastasis.

  2. Age-related changes in the plasticity and toughness of human cortical bone at multiple length-scales

    SciTech Connect (OSTI)

    Zimmermann, Elizabeth A.; Schaible, Eric; Bale, Hrishikesh; Barth, Holly D.; Tang, Simon Y.; Reichert, Peter; Busse, Bjoern; Alliston, Tamara; Ager III, Joel W.; Ritchie, Robert O.

    2011-08-10

    The structure of human cortical bone evolves over multiple length-scales from its basic constituents of collagen and hydroxyapatite at the nanoscale to osteonal structures at nearmillimeter dimensions, which all provide the basis for its mechanical properties. To resist fracture, bone’s toughness is derived intrinsically through plasticity (e.g., fibrillar sliding) at structural-scales typically below a micron and extrinsically (i.e., during crack growth) through mechanisms (e.g., crack deflection/bridging) generated at larger structural-scales. Biological factors such as aging lead to a markedly increased fracture risk, which is often associated with an age-related loss in bone mass (bone quantity). However, we find that age-related structural changes can significantly degrade the fracture resistance (bone quality) over multiple lengthscales. Using in situ small-/wide-angle x-ray scattering/diffraction to characterize sub-micron structural changes and synchrotron x-ray computed tomography and in situ fracture-toughness measurements in the scanning electron microscope to characterize effects at micron-scales, we show how these age-related structural changes at differing size-scales degrade both the intrinsic and extrinsic toughness of bone. Specifically, we attribute the loss in toughness to increased non-enzymatic collagen cross-linking which suppresses plasticity at nanoscale dimensions and to an increased osteonal density which limits the potency of crack-bridging mechanisms at micron-scales. The link between these processes is that the increased stiffness of the cross-linked collagen requires energy to be absorbed by “plastic” deformation at higher structural levels, which occurs by the process of microcracking.

  3. Enhancement of bone marrow allografts from nude mice into mismatched recipients by T cells void of graft-versus-host activity

    SciTech Connect (OSTI)

    Lapidot, T.; Lubin, I.; Terenzi, A.; Faktorowich, Y.; Erlich, P.; Reisner, Y. (Weizmann Institute of Science, Rehovot (Israel))

    1990-06-01

    Transplantation of 8 x 10(6) C57BL/6-Nu+/Nu+ (nude) bone marrow cells into C3H/HeJ recipients after conditioning with 8 Gy of total body irradiation has resulted in a markedly higher rate of graft rejection or graft failure compared to that found in recipients of normal C57BL/6 or C57BL/6-Bg+/Bg+ (beige) T-cell-depleted bone marrow. Mixing experiments using different numbers of nude bone marrow cells with or without mature thymocytes (unagglutinated by peanut agglutinin) revealed that engraftment of allogeneic T-cell-depleted bone marrow is T-cell dependent. To ensure engraftment, a large inoculum of nude bone marrow must be supplemented with a trace number of donor T cells, whereas a small bone marrow dose from nude donors requires a much larger number of T cells for engraftment. Marked enhancement of donor type chimerism was also found when F1 thymocytes were added to nude bone marrow cells, indicating that the enhancement of bone marrow engraftment by T cells is not only mediated by alloreactivity against residual host cells but may rather be generated by growth factors, the release of which may require specific interactions between T cells and stem cells or between T cells and bone marrow stroma cells.

  4. Influence of zinc on growth and bone maturation in children with end stage renal disease (ESRD)

    SciTech Connect (OSTI)

    Hagan, D.; Fleischmann, L.; Schemmel, R.A.

    1986-03-05

    Children with ESRD, age 5-19 years, were supplemented with zinc acetate (2 mg/kg BW, maximum 40 mg/da/child) to determine if zinc supplements (ZS) would improve growth and bone maturation. Twelve children completed the study. Three of the 12 did not receive ZS. Seven of the 9 ZS children were followed for 1 year pre- and 1 yr during-ZS. Two subjects were followed for shorter periods of time. Heights, weights, and hand wrist radiographs were taken at the beginning of the study, just pre-ZS, and at the end of the study. Blood was analyzed for serum alkaline phosphatase and albumin monthly. Alkaline phosphatase was elevated in 7 of 12 subjects pre-ZS and in 5 of 9 subjects post-ZS. Albumin levels were below normal in 7 subjects pre-ZS and 4 subjects post-ZS. Mean plasma Zn and Cu levels, 97+/-17 and 164+/-42 mcg/dl, pre-ZS, and 102+/-30 and 173+/-46 mcg/dl post-ZS, respectively, were similar. Growth velocity in males (4.1+/-2.2 cm/yr, 3.0+/-2.3 cm/yr) and females (3.9+/-0.7, 3.3+/-2.1 cm/yr) pre- and post-ZS, respectively, were similar. Bone maturation per chronological age improved after ZS in 4 of 6 subjects, 1 matured at the same rate, and one at a slower rate. It appears that ZS of children with ESRD increased the rate of bone maturation but not linear growth.

  5. Long bone growth of Mimbres subadults from the NAN Ranch (LA15049), New Mexico 

    E-Print Network [OSTI]

    Marek, Marianne

    1990-01-01

    of 559 skeletons from three time periods (Late Woodland, Mississippian Acculturated Late Woodland, and Table 2. 2. Indian Knoll maximum long bone length (cm) without epiphysis*. 10 13 14 15 16 17 18 2. 5 ? 3. 5 yr. 3. 5 ? 4. 5 yr. 4. 5 ? 5. 5... yr. 5. 5 ? 6. 5 yr. 6. 5 ? 8 yr. 8 ? 10. 5 yr. 10. 5 ? 11 yr. 11 ? 12 yr. 12 yl ~ 15 yr. + 6 mo. 15 yr. 16 yz' ~ 16. 5 ? 17 yr. 21 yr ~ Age Group Age 1 Birth ? 6 mo. 6 ? 15 mo. 15 ? 24 mo. 4 2 ? 2. 5 yr. Humerus N Mean SD Range 5...

  6. Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone

    SciTech Connect (OSTI)

    Barth, Holly; Zimmermann, Elizabeth; Schaible, Eric; Tang, Simon; Alliston, Tamara; Ritchie, Robert

    2011-08-19

    Bone comprises a complex structure of primarily collagen, hydroxyapatite and water, where each hierarchical structural level contributes to its strength, ductility and toughness. These properties, however, are degraded by irradiation, arising from medical therapy or bone-allograft sterilization. We provide here a mechanistic framework for how irradiation affects the nature and properties of human cortical bone over a range of characteristic (nano to macro) length-scales, following x-­ray exposures up to 630 kGy. Macroscopically, bone strength, ductility and fracture resistance are seen to be progressively degraded with increasing irradiation levels. At the micron-­scale, fracture properties, evaluated using in-situ scanning electron microscopy and synchrotron x-ray computed micro-tomography, provide mechanistic information on how cracks interact with the bone-matrix structure. At sub-micron scales, strength properties are evaluated with in-situ tensile tests in the synchrotron using small-/wide-angle x-ray scattering/diffraction, where strains are simultaneously measured in the macroscopic tissue, collagen fibrils and mineral. Compared to healthy bone, results show that the fibrillar strain is decreased by ~40% following 70 kGy exposures, consistent with significant stiffening and degradation of the collagen. We attribute the irradiation-­induced deterioration in mechanical properties to mechanisms at multiple length-scales, including changes in crack paths at micron-­scales, loss of plasticity from suppressed fibrillar sliding at sub-­micron scales, and the loss and damage of collagen at the nano-­scales, the latter being assessed using Raman and Fourier-Transform-Infrared spectroscopy and a fluorometric assay.

  7. Property CV3 16:06 02/06/2006 1 Variability of the mechanical properties of bone, and its evolutionary

    E-Print Network [OSTI]

    Baxter, Paul D.

    properties; evolutionary optima 1. INTRODUCTION The objects of the work described in this paper mechanical properties of bone: Young's modulus, strain at failure, impact energy absorption and so on cannot insights may often be gained by doing so. For instance, except for very highly mineralised bone, bending

  8. Reactive oxygen species on bone mineral density and mechanics in Cu,Zn superoxide dismutase (Sod1) knockout mice

    SciTech Connect (OSTI)

    Smietana, Michael J. [Biomedical Engineering, University of Michigan, 2025 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 (United States)] [Biomedical Engineering, University of Michigan, 2025 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 (United States); Arruda, Ellen M. [Biomedical Engineering, University of Michigan, 2025 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 (United States) [Biomedical Engineering, University of Michigan, 2025 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 (United States); Mechanical Engineering, University of Michigan, 2250 GG Brown, 2350 Hayward, Ann Arbor, MI 48109 (United States); Program in Macromolecular Science and Engineering, University of Michigan, 2250 GG Brown, 2350 Hayward, Ann Arbor, MI 48109 (United States); Faulkner, John A.; Brooks, Susan V. [Biomedical Engineering, University of Michigan, 2025 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 (United States) [Biomedical Engineering, University of Michigan, 2025 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 (United States); Molecular and Integrative Physiology, University of Michigan, 2025 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 (United States); Larkin, Lisa M., E-mail: llarkin@umich.edu [Biomedical Engineering, University of Michigan, 2025 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 (United States); Molecular and Integrative Physiology, University of Michigan, 2025 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 (United States)

    2010-12-03

    Research highlights: {yields} Reactive oxygen species (ROS) are considered to be a factor in the onset of a number of age-associated conditions, including loss of BMD. {yields} Cu,Zn-superoxide dismutase (Sod1) deficient mice have increased ROS, reduced bone mineral density, decreased bending stiffness, and decreased strength compared to WT controls. {yields} Increased ROS caused by the deficiency of Sod1, may be responsible for the changes in BMD and bone mechanics and therefore represent an appropriate model for studying mechanisms of age-associated bone loss. -- Abstract: Reactive oxygen species (ROS) play a role in a number of degenerative conditions including osteoporosis. Mice deficient in Cu,Zn-superoxide dismutase (Sod1) (Sod1{sup -/-} mice) have elevated oxidative stress and decreased muscle mass and strength compared to wild-type mice (WT) and appear to have an accelerated muscular aging phenotype. Thus, Sod1{sup -/-} mice may be a good model for evaluating the effects of free radical generation on diseases associated with aging. In this experiment, we tested the hypothesis that the structural integrity of bone as measured by bending stiffness (EI; N/mm{sup 2}) and strength (MPa) is diminished in Sod1{sup -/-} compared to WT mice. Femurs were obtained from male and female WT and Sod1{sup -/-} mice at 8 months of age and three-point bending tests were used to determine bending stiffness and strength. Bones were also analyzed for bone mineral density (BMD; mg/cc) using micro-computed tomography. Femurs were approximately equal in length across all groups, and there were no significant differences in BMD or EI with respect to gender in either genotype. Although male and female mice demonstrated similar properties within each genotype, Sod1{sup -/-} mice exhibited lower BMD and EI of femurs from both males and females compared with gender matched WT mice. Strength of femurs was also lower in Sod1{sup -/-} mice compared to WT as well as between genders. These data indicate that increased oxidative stress, due to the deficiency of Sod1 is associated with decreased bone stiffness and strength and Sod1{sup -/-} mice may represent an appropriate model for studying disease processes in aging bone.

  9. Spectral analysis and connectivity of porous microstructures in bone Kenneth M. Golden , N. Benjamin Murphy, Elena Cherkaev

    E-Print Network [OSTI]

    Cherkaev, Elena

    also help assess the impact of osteoporosis on trabecular structure. Central to our approach- structures, ranging from a solid network of connected trabeculae containing numerous connected pores, in dense cortical bone the pores can be sparse and disconnected, yet exhibit increasing volume fraction

  10. DESIGN OF FOAM COVERING FOR ROBOTIC ARMS TO ENSURE HUMAN SAFETY Lingqi Zeng and Gary M. Bone

    E-Print Network [OSTI]

    Bone, Gary

    , and robot and human velocities. The impact experiments are performed with an apparatus simulating the humanDESIGN OF FOAM COVERING FOR ROBOTIC ARMS TO ENSURE HUMAN SAFETY Lingqi Zeng and Gary M. Bone@mcmaster.ca ABSTRACT Unintentional physical human-robot contact is becoming more common as robots operate in closer

  11. Poly(e-caprolactone) Composites Containing Gentamicin-Loaded b-Tricalcium Phosphate/Gelatin Microspheres as Bone Tissue Supports

    E-Print Network [OSTI]

    Hasýrcý, Vasýf

    Poly(e-caprolactone) Composites Containing Gentamicin-Loaded b-Tricalcium Phosphate/Gelatin-tricalcium phosphate (b-TCP) and gelatin. The purpose is to use this biode- gradable material as a support for bone. The effects of the ratio of the b-TCP/gelatin microspheres on the morphological, mechanical, and degradation

  12. Further evaluation of the efficacy of contamination removal from bone Jodi Lynn Barta a,b,c

    E-Print Network [OSTI]

    Kemp, Brian M.

    Further evaluation of the efficacy of contamination removal from bone surfaces Jodi Lynn Barta a, it simultaneously represents a system that is hypersen- sitive to amplifying contaminant DNA [7­9]. Tempering) and degraded DNA are prone to contamination from exogenous DNA sources that in some cases can out

  13. The effect of alcohol on the bone growth spurt of rats at a time equivalent to adolescent females 

    E-Print Network [OSTI]

    Chaffin, Catherine Lee

    1997-01-01

    2, 4, 6 and 8 weeks after the feeding began. I-Estomorphometric analyses were performed using a BioQuant Morphometric system on 5um undecalcified longitudinal sections of the proximal tibia. A decrease in the amount of trabecular bone was found...

  14. Genetic Inactivation of ERK1 and ERK2 in Chondrocytes Promotes Bone Growth and Enlarges the Spinal Canal

    E-Print Network [OSTI]

    Genetic Inactivation of ERK1 and ERK2 in Chondrocytes Promotes Bone Growth and Enlarges the Spinal dysplasia. In mouse models of achondroplasia, recent studies have implicated the ERK MAPK pathway, a pathway and ERK MAPK signaling in chondrocytes also causes premature synchondrosis closure in the cranial base

  15. A new technique for imaging Mineralized Fibrils on Bovine Trabecular Bone Fracture Surfaces by Atomic Force Microscopy

    E-Print Network [OSTI]

    Hansma, Paul

    A new technique for imaging Mineralized Fibrils on Bovine Trabecular Bone Fracture Surfaces coated with extrafibrillar mineral particles. The mineral particles are distinctly different in different collagen fibrils. If the observed particles can be verified to be native extrafibrillar mineral, this could

  16. The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial

    E-Print Network [OSTI]

    Boyer, Edmond

    in a water-soluble cellulose polymer carrier phase. It was used for filling bone defects after tooth extractions in eleven patients. The first objective of the study was to investigate the safety of the filler of the implanted areas were harvested and analyzed by using micro-computed tomography, non-decalcified histology

  17. Fracture Mechanisms of Bone: A Comparative Study between Antler and Bovine Femur , F.A. Sheppard2

    E-Print Network [OSTI]

    McKittrick, Joanna

    Fracture Mechanisms of Bone: A Comparative Study between Antler and Bovine Femur P.Y. Chen1 , F, University of California, San Diego, La Jolla, CA 92093-0411, U.S.A. ABSTRACT In this study, fracture conditions to study the effects of fiber orientation and hydration. Fracture toughness results

  18. Predicting hip fracture type with cortical bone mapping (CBM) in the Osteoporotic Fractures in Men (MrOS) study

    E-Print Network [OSTI]

    Drummond, Tom

    Predicting hip fracture type with cortical bone mapping (CBM) in the Osteoporotic Fractures in Men, for the Osteoporotic Fractures in Men (MrOS) study CUED/F-INFENG/TR 695 January 2015 Cambridge University Engineering;1 Abstract Hip fracture risk is known to be related to material properties of the proximal femur, but prospec

  19. Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model

    SciTech Connect (OSTI)

    Orozco, Johnnie J.; Back, Tom; Kenoyer, Aimee L.; Balkin, Ethan R.; Hamlin, Donald K.; Wilbur, D. Scott; Fisher, Darrell R.; Frayo, Shani; Hylarides, Mark; Green, Damian J.; Gopal, Ajay K.; Press, Oliver W.; Pagel, John M.

    2013-05-15

    Anti-CD45 Radioimmunotherapy using an Alpha-Emitting Radionuclide 211At Combined with Bone Marrow Transplantation Prolongs Survival in a Disseminated Murine Leukemia Model ABSTRACT Despite aggressive chemotherapy combined with hematopoietic cell transplant (HCT), many patients with acute myeloid leukemia (AML) relapse. Radioimmunotherapy (RIT) using antibodies (Ab) labeled primarily with beta-emitting radionuclides has been explored to reduce relapse.

  20. Purification of Matrix Gla Protein From a Marine Teleost Fish, Argyrosomus regius: Calcified Cartilage and Not Bone

    E-Print Network [OSTI]

    Price, Paul A.

    Purification of Matrix Gla Protein From a Marine Teleost Fish, Argyrosomus regius: Calcified Cartilage and Not Bone as the Primary Site of MGP Accumulation in Fish DC SIMES,1 MK WILLIAMSON,2 JB ORTIZ to accumulate in vertebra of shark, a cartilaginous fish. However, to date, no information is available on sites

  1. Liquid-Solid Phase Transition Alloy as Reversible and Rapid Molding Bone Cement

    E-Print Network [OSTI]

    Yi, Liting; Liu, Jing

    2013-01-01

    Bone cement has been demonstrated as an essential restorative material in the orthopedic surgery. However current materials often imply unavoidable drawbacks, such as tissue-cement reaction induced thermal injuries and troublesome revision procedure. Here we proposed an injectable alloy cement to address such problems through its liquid-solid phase transition mechanism. The cement is made of a unique alloy BiInSnZn with a specifically designed low melting point 57.5{\\deg}C. This property enables its rapid molding into various shapes with high plasticity. Some fundamental characteristics including mechanical strength behaviors and phase transition-induced thermal features have been measured to demonstrate the competence of alloy as unconventional cement with favorable merits. Further biocompatible tests showed that this material could be safely employed in vivo. In addition, experiments also found the alloy cement capability as an excellent contrast agent for radiation imaging. Particularly, the proposed alloy...

  2. Abrogation of hybrid resistance to bone marrow engraftment by graft versus host induced immune deficiency

    SciTech Connect (OSTI)

    Hakim, F.T.; Shearer, G.M.

    1986-03-01

    Lethally irradiated F/sub 1/ mice, heterozygous at the hematopoietic histocompatibility (Hh) locus at H-2D/sup b/, reject bone marrow grafts from homozygous H-2/sup b/ parents. This hybrid resistance (HR) is reduced by prior injection of H-2/sup b/ parental spleen cells. Since injection of parental spleen cells produces a profound suppression of F/sub 1/ immune functions, the authors investigated whether parental-induced abrogation of HR was due to graft-vs-host induced immune deficiency (GVHID). HR was assessed by quantifying engraftment in irradiated mice using /sup 125/I-IUdR spleen uptake; GVHID by measuring generation of cytotoxic T lymphocytes (CTL) from unirradiated mice. They observed correlation in time course, spleen dose dependence and T cell dependence between GVHID and loss of HR. The injection of B10 recombinant congenic spleens into (B10 x B10.A) F/sub 1/ mice, prior to grafting with B10 marrow, demonstrated that only those disparities in major histocompatibility antigens which generated GVHID would result in loss of HR. Spleens from (B10 x B10.A(2R))F/sub 1/ mice (Class I disparity only) did not induce GVHID or affect HR, while (B10 x B10.A(5R)F/sub 1/ spleens (Class I and II disparity) abrogated CTL generation and HR completely. GVHID produced by a Class II only disparity, as in (B10 x B10.A(5R))F/sub 1/ spleens injected into (B6/sup bm12 x B10.A(5R))F/sub 1/ mice, was also sufficient to markedly reduce HR to B10 bone marrow. Modulation of hematopoietic graft rejection by GVHID may affect marrow engraftment in man.

  3. Nanomechanics and ultrastructural studies of cortical bone : fundamental insights regarding structure-function, mineral-organic force mechanics interactions, and heterogeneity

    E-Print Network [OSTI]

    Tai, Kuangshin

    2007-01-01

    Although the mechanics of bone has been studied extensively at the micro- and macro-scale, the nano-scopic level is perhaps the most illuminating as this is the length scale at which the individual constituents interact. ...

  4. Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation

    E-Print Network [OSTI]

    Park, Sang-Hyug

    Adipose tissue-derived stem cells (ASCs) are considered as an attractive stem cell source for tissue engineering and regenerative medicine. We compared human bone marrow-derived mesenchymal stem cells (hMSCs) and hASCs ...

  5. A Signal-Inducing Bone Cement for Magnetic Resonance Imaging-Guided Spinal Surgery Based on Hydroxyapatite and Polymethylmethacrylate

    SciTech Connect (OSTI)

    Wichlas, Florian, E-mail: florian.wichlas@charite.de; Seebauer, Christian J.; Schilling, Rene [University Charite, Center for Musculoskeletal Surgery (Germany); Rump, Jens [University Charite, Department of Radiology (Germany); Chopra, Sascha S. [University Charite, Center for Musculoskeletal Surgery (Germany); Walter, Thula; Teichgraeber, Ulf K. M. [University Charite, Department of Radiology (Germany); Bail, Hermann J. [University Charite, Center for Musculoskeletal Surgery (Germany)

    2012-06-15

    The aim of this study was to develop a signal-inducing bone cement for magnetic resonance imaging (MRI)-guided cementoplasty of the spine. This MRI cement would allow precise and controlled injection of cement into pathologic lesions of the bone. We mixed conventional polymethylmethacrylate bone cement (PMMA; 5 ml methylmethacrylate and 12 g polymethylmethacrylate) with hydroxyapatite (HA) bone substitute (2-4 ml) and a gadolinium-based contrast agent (CA; 0-60 {mu}l). The contrast-to-noise ratio (CNR) of different CA doses was measured in an open 1.0-Tesla scanner for fast T1W Turbo-Spin-Echo (TSE) and T1W TSE pulse sequences to determine the highest signal. We simulated MRI-guided cementoplasty in cadaveric spines. Compressive strength of the cements was tested. The highest CNR was (1) 87.3 (SD 2.9) in fast T1W TSE for cements with 4 {mu}l CA/ml HA (4 ml) and (2) 60.8 (SD 2.4) in T1W TSE for cements with 1 {mu}l CA/ml HA (4 ml). MRI-guided cementoplasty in cadaveric spine was feasible. Compressive strength decreased with increasing amounts of HA from 46.7 MPa (2 ml HA) to 28.0 MPa (4 ml HA). An MRI-compatible cement based on PMMA, HA, and CA is feasible and clearly visible on MRI images. MRI-guided spinal cementoplasty using this cement would permit direct visualization of the cement, the pathologic process, and the anatomical surroundings.

  6. Percentage depth dose distributions in inhomogeneous phantoms with lung and bone equivalent media for small fields of CyberKnife

    E-Print Network [OSTI]

    Lee, Chung Il; Yoon, Sei-Chul; Suh, Tae Suk; Hong, Seung-Woo; Min, Kyung Joo; Lee, Sang Deok; Chung, Su Mi; Jung, Jae-Yong

    2014-01-01

    The percentage depth dose distributions in inhomogeneous phantoms with lung and bone equivalent media are studied. For lung equivalent media a Balsa wood is used, and for a soft bone equivalent media a compound material with epoxy resin, hardener and calcium carbonate is used. Polystyrene slabs put together with these materials are used as an inhomogeneous phantom. Dose measurements are performed with Gafchromic EBT film by using photon beams from 6MV CyberKnife at the Seoul Uridul Hospital. The cone sizes of the photon beams are varied from 5, 10 to 30 mm. As a simulation tool GEANT4 Monte Carlo code v9.4.p02 is used. When the Balsa wood is inserted in the phantom, the dose measured with EBT film is found to be significantly different from the dose without the EBT film in and beyond the Balsa wood region, particularly for small field sizes. On the other hand, when the soft bone equivalent material is inserted in the phantom, discrepancy between the dose measured with EBT film and the dose without EBT film ca...

  7. FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Benz, Matthias R.; Czernin, Johannes; Tap, William D.; Eckardt, Jeffrey J.; Seeger, Leanne L.; Allen-Auerbach, Martin S.; Dry, Sarah M.; Phelps, Michael E.; Weber, Wolfgang A.; Eilber, Fritz C.

    2010-01-01

    Purpose. The aim of this study was to prospectively evaluate whether FDG-PET allows an accurate assessment of histopathologic response to neoadjuvant treatment in adult patients with primary bone sarcomas.Methods. Twelve consecutive patients with resectable, primary high grade bone sarcomas were enrolled prospectively. FDG-PET/CT imaging was performed prior to the initiation and after completion of neoadjuvant treatment. Imaging findings were correlated with histopathologic response.Results. Histopathologic responders showed significantly more pronounced decreases in tumor FDG-SUVmax from baseline to late follow up than non-responders (64±19% versus29±30%, resp.;P=.03). Using a 60% decrease in tumor FDG-uptake as a threshold for metabolic response correctly classified 3more »of 4 histopathologic responders and 7 of 8 histopathologic non-responders as metabolic responders and non-responders, respectively (sensitivity, 75%; specificity, 88%).Conclusion. These results suggest that changes in FDG-SUVmax at the end of neoadjuvant treatment can identify histopathologic responders and non-responders in adult primary bone sarcoma patients.« less

  8. Patterns of Practice of Palliative Radiotherapy in Africa, Part 1: Bone and Brain Metastases

    SciTech Connect (OSTI)

    Sharma, Vinay Gaye, Papa Macoumba M.Med.; Wahab, Sherif Abdel; Ndlovu, Ntokozo; Ngoma, Twalib; Vanderpuye, Verna; Sowunmi, Anthonia; Kigula-Mugambe, Joseph; Jeremic, Branislav

    2008-03-15

    Purpose: To provide data on the pattern of practice of palliative radiotherapy (RT) on the African continent. Methods and Materials: A questionnaire was distributed to participants in a regional training course of the International Atomic Energy Agency in palliative cancer care and sent by e-mail to other institutions in Africa. Requested information included both infrastructure and human resources available and the pattern of RT practice for metastatic and locally advanced cancers. Results: Of 35 centers contacted, 24 (68%) completed the questionnaire. Although RT is used by most centers for most metastatic cancers, liver and lung metastases are treated with chemotherapy. Of 23 centers, 14 (61%) had a single RT regimen as an institutional policy for treating painful bone metastases, but only 5 centers (23%) of 23 used 8 Gy in 1 fraction. Brain metastases were being treated by RT to the whole brain to 30 Gy in 10 fractions, either exclusively (n = 13, 56%) or in addition to the use of 20 Gy in 5 fractions (n = 3, 14%). Conclusion: Radiotherapy is a major component of treatment of cancer patients in African countries. There is consensus among few centers for treatment schedules for almost all sites regarding time and dose-fractionation characteristics of RT regimens used and/or indications for the use of RT in this setting.

  9. Patterns of Practice in Palliative Radiotherapy for Painful Bone Metastases: A Survey in Japan

    SciTech Connect (OSTI)

    Nakamura, Naoki; Shikama, Naoto; Wada, Hitoshi; Harada, Hideyuki; Nozaki, Miwako; Nagakura, Hisayasu; Tago, Masao; Oguchi, Masahiko; Uchida, Nobue

    2012-05-01

    Purpose: To determine the current patterns of practice in Japan and to investigate factors that may make clinicians reluctant to use single-fraction radiotherapy (SF-RT). Methods and Materials: Members of the Japanese Radiation Oncology Study Group (JROSG) completed an Internet-based survey and described the radiotherapy dose fractionation they would recommend for four hypothetical cases describing patients with painful bone metastasis (BM). Case 1 described a patient with an uncomplicated painful BM in a non-weight-bearing site from non-small-cell lung cancer. Case 2 investigated whether management for a case of uncomplicated spinal BM would be different from that in Case 1. Case 3 was identical with Case 2 except for the presence of neuropathic pain. Case 4 investigated the prescription for an uncomplicated painful BM secondary to oligometastatic breast cancer. Radiation oncologists who recommended multifraction radiotherapy (MF-RT) for Case 2 were asked to explain why they considered MF-RT superior to SF-RT. Results: A total of 52 radiation oncologists from 50 institutions (36% of JROSG institutions) responded. In all four cases, the most commonly prescribed regimen was 30 Gy in 10 fractions. SF-RT was recommended by 13% of respondents for Case 1, 6% for Case 2, 0% for Case 3, and 2% for Case 4. For Case 4, 29% of respondents prescribed a high-dose MF-RT regimen (e.g., 50 Gy in 25 fractions). The following factors were most often cited as reasons for preferring MF-RT: 'time until first increase in pain' (85%), 'incidence of spinal cord compression' (50%), and 'incidence of pathologic fractures' (29%). Conclusions: Japanese radiation oncologists prefer a schedule of 30 Gy in 10 fractions and are less likely to recommend SF-RT. Most Japanese radiation oncologists regard MF-RT as superior to SF-RT, based primarily on the time until first increase in pain.

  10. Cyclophilin A (CypA) is associated with the inflammatory infiltration and alveolar bone destruction in an experimental periodontitis

    SciTech Connect (OSTI)

    Liu, Lihua; Li, Chengzhang; Department of Periodontology, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 ; Cai, Cia; Xiang, Junbo; Cao, Zhengguo; Department of Periodontology, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079

    2010-01-01

    Background and objective: CypA is able to regulate inflammatory responses and MMPs production via interaction with its cell surface receptor, EMMPRIN. This study aimed to address the possible association of CypA with pathological inflammation and destruction of periodontal tissues, and whether CypA-EMMPRIN interaction exists in periodontitis. Materials and methods: Experimental periodontitis was induced by ligation according to our previous method. Histological and radiographic examinations were performed. Western blot was used to detect CypA and EMMPRIN expressions in gingival tissues. Immunohistochemistry was applied for CypA, EMMPRIN, MMP-1, MMP-2, MMP-9, as well as cell markers of macrophage, lymphocyte and neutrophil. CypA expression, alveolar bone loss, and inflammatory infiltrations were quantified followed by correlation analyses. Results: Western blot revealed that CypA and EMMRPIN expressions were dramatically elevated in inflamed gingival tissues (ligature group) as compared to healthy gingival tissues (control group). The enhanced CypA and EMMPRIN expressions were highly consistent in cell localization on seriate sections. They were permanently co-localized in infiltrating macrophages and lymphocytes, as well as osteoclasts and osteoblasts in interradicular bone, but rarely expressed by infiltrating neutrophils. MMP-1, MMP-2, and MMP-9 expressions were also sharply increased in inflamed gingiva. MMP-2 and MMP-9 were mainly over-expressed by macrophages, while MMP-1 was over-produced by fibroblasts and infiltrating cells. The number of CypA-positive cells was strongly correlated with the ACJ-AC distance (r = 0.839, p = 0.000), the number of macrophages (r = 0.972, p = 0.000), and the number of lymphocytes (r = 0.951, p = 0.000). Conclusion: CypA is associated with the inflammatory infiltration and alveolar bone destruction of periodontitis. CypA-EMMPRIN interaction may exist in these pathological processes.

  11. Predicting hip fracture type with cortical bone mapping (CBM) in the Osteoporotic Fractures in Men (MrOS) study

    E-Print Network [OSTI]

    Treece, Graham M.; Gee, Andrew H.; Tonkin, Carol; Ewing, Susan K.; Cawthon, Peggy M.; Black, Dennis M.; Poole, Kenneth E. S.; Osteoporotic Fractures in Men Study

    2015-03-18

    for hazard ratios were conducted in SAS version 9.1 (SAS Institute, Cary, NC, USA). In addition, we examined the ability of models involving different groups of variables to predict ten-year fracture incidence, by performing either binomial (any fracture... CD, Delmas P, et al. Predictive value of BMD for hip and other fractures. J Bone Miner Res. 2005;20(7):1185–1194. 3. Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster JY, Borgstrom F, et al. European guidance for the diagnosis and management...

  12. The Role of Leptin and Other Hormones Related to Bone Metabolism and Appetite Regulation as Determinants of Gain in Body Fat and Fat-Free Mass in 8 –11-Year-Old Children

    E-Print Network [OSTI]

    Dalskov, Stine-Mathilde; Ritz, Christian; Larnkjær, Anni; Damsgaard, Camilla T.; Petersen, Rikke A.; Sørensen, Louise B.; Ong, Ken K.; Astrup, Arne; Mølgaard, Christian; Michaelsen, Kim F.

    2014-12-22

    to the mineralization or demineralization of bones, like the bone 53 formation marker osteocalcin, and the calcium-mobilizing parathyroid hormone (PTH), have been 54 linked with energy metabolism and body fat deposition (23-26), but more knowledge is needed for 55...

  13. Changes in bone morphology and composition following long-term alcohol consumption 

    E-Print Network [OSTI]

    Hebert, Valerie Anne

    1998-01-01

    sacrificed 3, 6, 9, 12, and 18 months after feeding was initiated. Using right femurs and left tibias, morphological data, wet-weight, percent water, and volume were determined. Throughout a drying and ashing period, dry weight, fat-free weight, percent fat...

  14. The Influence of Running on Patellar Water Content and Bone Marrow Edema in Females with and without Patellofemoral , H. H. Hu2

    E-Print Network [OSTI]

    Southern California, University of

    The Influence of Running on Patellar Water Content and Bone Marrow Edema in Females marrow water content changes in individuals with and without PFP. To accomplish this goal, we used the water content of the images measured. Equation 2 was used to estimate the water volume of local BME. Eq

  15. Probing dietary change of the Kwaday Dan Ts'i`nchi individual, an ancient glacier body from British Columbia: II. Deconvoluting whole skin and bone

    E-Print Network [OSTI]

    Kohler, Tim A.

    British Columbia: II. Deconvoluting whole skin and bone collagen d13 C values via carbon isotope analysis Beattie e , Richard P. Evershed a,* a Organic Geochemistry Unit, Bristol Biogeochemistry Research Centre Department of Anthropology, Washington State University, Pullman, WA 99164-4910, USA d British Columbia

  16. CX3CR1 Is Expressed by Prostate Epithelial Cells and Androgens Regulate the Levels of CX3CL1/Fractalkine in the Bone Marrow

    E-Print Network [OSTI]

    Fatatis, Alessandro

    CX3CR1 Is Expressed by Prostate Epithelial Cells and Androgens Regulate the Levels of CX3CL1 human osteoblasts in vitro. Thus, the interaction of fractalkine with its receptor CX3CR1 could play a crucial role in vivo by directing circulating prostate cancer cells to the bone. We found that although CX

  17. UNCW BASIC e~PRINT GUIDE This is the "bare bones" guide to viewing your Banner reports on the web. Please refer to the

    E-Print Network [OSTI]

    Olszewski Jr., Edward A.

    UNCW BASIC e~PRINT GUIDE This is the "bare bones" guide to viewing your Banner reports on the web will display. This page lists the different reports you have access to view. The "Latest Date" indicates the last time the report was run. #12;4. Left Click on the PDF icon to view the latest version

  18. Na, K, Ca, Mg, and U-series in fossil bone and the proposal of a radial diffusioneadsorption model of uranium uptake

    E-Print Network [OSTI]

    Nacional de San Luis, Universidad

    of uranium uptake A.S. Cid a , R.M. Anjos a, * , C.B. Zamboni b , R. Cardoso a , M. Muniz a , A. Corona c , D-series dating Neutron activation analysis Uranium uptake Radial diffusioneadsorption model a b s t r a c- logical sites. However, since bone is an open system for uranium, it cannot be dated directly

  19. Sacrificial bonds and hidden length in biomaterials -- a kinetic, constitutive description of strength and toughness in bone

    E-Print Network [OSTI]

    Lieou, Charles K C; Carlson, Jean M

    2013-01-01

    Sacrificial bonds and hidden length in structural molecules account for the greatly increased fracture toughness of biological materials compared to synthetic materials without such structural features, by providing a molecular-scale mechanism for energy dissipation. One example is in the polymeric glue connection between collagen fibrils in animal bone. In this paper, we propose a simple kinetic model that describes the breakage of sacrificial bonds and the release of hidden length, based on Bell's theory. We postulate a master equation governing the rates of bond breakage and formation. This enables us to predict the mechanical behavior of a quasi-one-dimensional ensemble of polymers at different stretching rates. We find that both the rupture peak heights and maximum stretching distance increase with the stretching rate. In addition, our theory naturally permits the possibility of self-healing in such biological structures.

  20. Sacrificial bonds and hidden length in biomaterials -- a kinetic, constitutive description of strength and toughness in bone

    E-Print Network [OSTI]

    Charles K. C. Lieou; Ahmed E. Elbanna; Jean M. Carlson

    2013-01-25

    Sacrificial bonds and hidden length in structural molecules account for the greatly increased fracture toughness of biological materials compared to synthetic materials without such structural features, by providing a molecular-scale mechanism for energy dissipation. One example is in the polymeric glue connection between collagen fibrils in animal bone. In this paper, we propose a simple kinetic model that describes the breakage of sacrificial bonds and the release of hidden length, based on Bell's theory. We postulate a master equation governing the rates of bond breakage and formation. This enables us to predict the mechanical behavior of a quasi-one-dimensional ensemble of polymers at different stretching rates. We find that both the rupture peak heights and maximum stretching distance increase with the stretching rate. In addition, our theory naturally permits the possibility of self-healing in such biological structures.

  1. Compositional and in Vitro Evaluation of Nonwoven Type I Collagen/Poly-dl-lactic Acid Scaffolds for Bone Regeneration

    E-Print Network [OSTI]

    Qiao, Xiangchen; Yang, Xuebin; Tronci, Giuseppe; Wood, David J

    2015-01-01

    Poly-dl-lactic acid (PDLLA) was blended with type I collagen to attempt to overcome the instantaneous gelation of electrospun collagen scaffolds in biological environments. Scaffolds based on blends of type I collagen and PDLLA were investigated for material stability in cell culture conditions (37 {\\deg}C; 5% CO2) in which post-electrospinning glutaraldehyde crosslinking was also applied. The resulting wet-stable webs were cultured with bone marrow stromal cells (HBMSC) for five weeks. Scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), Fourier transform infra-red spectroscopy (FTIR) and biochemical assays were used to characterise the scaffolds and the consequent cell-scaffold constructs. To investigate any electrospinning-induced denaturation of collagen, identical PDLLA/collagen and PDLLA/gelatine blends were electrospun and their potential to promote osteogenic differentiation investigated. PDLLA/collagen blends with w/w ratios of 40/60, 60/40 and 80/20 resulted in satisfactory...

  2. Bone regenerative potential of mesenchymal stem cells on a micro-structured titanium processed by wire-type electric discharge machining

    E-Print Network [OSTI]

    Tamaki, Yukimichi; Miyazaki, Takashi

    2010-01-01

    A new strategy with bone tissue engineering by mesenchymal stem cell transplantation on titanium implant has been dawn attention. The surface scaffold properties of titanium surface play an important role in bone regenerative potential of cells. The surface topography and chemistry are postulated to be two major factors increasing the scaffold properties of titanium implants. This study aimed to evaluate the osteogenic gene expression of mesenchymal stem cells on titanium processed by wire-type electric discharge machining. Some amount of roughness and distinctive irregular features were observed on titanium processed by wire-type electric discharge machining. The thickness of suboxide layer was concomitantly grown during the processing. Since the thickness of oxide film and micro-topography allowed an improvement of mRNA expression of cells, titanium processed by wire-type electric discharge machining is a promising candidate for mesenchymal stem cell based functional restoration of implants.

  3. Comparative study of the chondrogenic potential of human bone marrow stromal cells, neonatal chondrocytes and adult chondrocytes

    SciTech Connect (OSTI)

    Saha, Sushmita; Kirkham, Jennifer; NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Chapel Allerton Hospital, Leeds LS74SA ; Wood, David; Curran, Stephen; Yang, Xuebin; NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Chapel Allerton Hospital, Leeds LS74SA

    2010-10-22

    Research highlights: {yields} This study has characterised three different cell types under conditions similar to those used for autologous chondrocyte implantation (ACI) for applications in cartilage repair/regeneration. {yields} Compared for the first time the chondrogenic potential of neonatal chondrocytes with human bone marrow stromal cells (HBMSCs) and adult chondrocytes. {yields} Demonstrated that adult chondrocytes hold greatest potential for use in ACI based on their higher proliferation rates, lower alkaline phosphatise activity and enhanced expression of chondrogenic genes. {yields} Demonstrated the need for chondroinduction as a necessary pre-requisite to efficient chondrogenesis in vitro and, by extrapolation, for cell based therapy (e.g. ACI or cartilage tissue engineering). -- Abstract: Cartilage tissue engineering is still a major clinical challenge with optimisation of a suitable source of cells for cartilage repair/regeneration not yet fully addressed. The aims of this study were to compare and contrast the differences in chondrogenic behaviour between human bone marrow stromal cells (HBMSCs), human neonatal and adult chondrocytes to further our understanding of chondroinduction relative to cell maturity and to identify factors that promote chondrogenesis and maintain functional homoeostasis. Cells were cultured in monolayer in either chondrogenic or basal medium, recapitulating procedures used in existing clinical procedures for cell-based therapies. Cell doubling time, morphology and alkaline phosphatase specific activity (ALPSA) were determined at different time points. Expression of chondrogenic markers (SOX9, ACAN and COL2A1) was compared via real time polymerase chain reaction. Amongst the three cell types studied, HBMSCs had the highest ALPSA in basal culture and lowest ALPSA in chondrogenic media. Neonatal chondrocytes were the most proliferative and adult chondrocytes had the lowest ALPSA in basal media. Gene expression analysis revealed a difference in the temporal expression of chondrogenic markers which were up regulated in chondrogenic medium compared to levels in basal medium. Of the three cell types studied, adult chondrocytes offer a more promising cell source for cartilage tissue engineering. This comparative study revealed differences between the microenvironment of all three cell types and provides useful information to inform cell-based therapies for cartilage regeneration.

  4. Effects of matrix metalloproteinase-1 on the myogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro

    SciTech Connect (OSTI)

    Zheng, Zhenyang [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China)] [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China); Leng, Yan [Department of Rehabilitation, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China)] [Department of Rehabilitation, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China); Zhou, Chen; Ma, Zhenyu; Zhong, Zhigang [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China)] [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China); Shi, Xing-Ming [Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, GA 30912 (United States)] [Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, GA 30912 (United States); Zhang, Weixi, E-mail: weixizhang@qq.com [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China)] [Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province (China)

    2012-11-16

    Highlights: Black-Right-Pointing-Pointer MMP-1 is a member of the zinc-dependent endopeptidase family. Black-Right-Pointing-Pointer MMP-1 has no cytotoxic effects on BMSCs. Black-Right-Pointing-Pointer MMP-1 can promote the myogenic differentiation of BMSCs. Black-Right-Pointing-Pointer MyoD and desmin were chosen as myogenic markers in this study. -- Abstract: Matrix metalloproteinase-1 (MMP-1) is a member of the family of zinc-dependent endopeptidases that are capable of degrading extracellular matrix (ECM) and certain non-matrix proteins. It has been shown that MMP-1 can enhance muscle regeneration by improving the differentiation and migration of myoblasts. However, it is still not known whether MMP-1 can promote the myogenesis of bone marrow-derived mesenchymal stem cells (BMSCs). To address this question, we isolated BMSCs from C57BL/6J mice and investigated the effects of MMP-1 on their proliferation and myogenic differentiation. Our results showed that MMP-1 treatment, which had no cytotoxic effects on BMSCs, increased the mRNA and protein levels of MyoD and desmin in a dose-dependent manner, indicating that MMP-1 promoted myogenic differentiation of BMSCs in vitro. These results suggest that BMSCs may have a therapeutic potential for treating muscular disorders.

  5. Ash Determinations 

    E-Print Network [OSTI]

    Unknown

    2011-08-17

    Germination of Ashe juniper seed were compared in a controlled environment at different levels of fruit maturation, lengths of storage, and seed stratification to determine potential germination. Annual mean germination varied by an order...

  6. Fibroblast growth factor 2 inhibits up-regulation of bone morphogenic proteins and their receptors during osteoblastic differentiation of human mesenchymal stem cells

    SciTech Connect (OSTI)

    Biver, Emmanuel, E-mail: ebiver@yahoo.fr [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France) [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France); Department of Rheumatology, Lille University Hospital, Roger Salengro Hospital, 59037 Lille cedex (France); Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, CH-1211 Geneva 14 (Switzerland); Soubrier, Anne-Sophie [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France) [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France); Department of Rheumatology, Lille University Hospital, Roger Salengro Hospital, 59037 Lille cedex (France); Thouverey, Cyril [Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, CH-1211 Geneva 14 (Switzerland)] [Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, CH-1211 Geneva 14 (Switzerland); Cortet, Bernard [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France) [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France); Department of Rheumatology, Lille University Hospital, Roger Salengro Hospital, 59037 Lille cedex (France); Broux, Odile [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France)] [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France); Caverzasio, Joseph [Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, CH-1211 Geneva 14 (Switzerland)] [Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, CH-1211 Geneva 14 (Switzerland); Hardouin, Pierre [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France)] [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France)

    2012-11-02

    Highlights: Black-Right-Pointing-Pointer FGF modulates BMPs pathway in HMSCs by down-regulating BMP/BMPR expression. Black-Right-Pointing-Pointer This effect is mediated by ERK and JNK MAPKs pathways. Black-Right-Pointing-Pointer Crosstalk between FGF and BMPs must be taken into account in skeletal bioengineering. Black-Right-Pointing-Pointer It must also be considered in the use of recombinant BMPs in orthopedic and spine surgeries. -- Abstract: Understanding the interactions between growth factors and bone morphogenic proteins (BMPs) signaling remains a crucial issue to optimize the use of human mesenchymal stem cells (HMSCs) and BMPs in therapeutic perspectives and bone tissue engineering. BMPs are potent inducers of osteoblastic differentiation. They exert their actions via BMP receptors (BMPR), including BMPR1A, BMPR1B and BMPR2. Fibroblast growth factor 2 (FGF2) is expressed by cells of the osteoblastic lineage, increases their proliferation and is secreted during the healing process of fractures or in surgery bone sites. We hypothesized that FGF2 might influence HMSC osteoblastic differentiation by modulating expressions of BMPs and their receptors. BMP2, BMP4, BMPR1A and mainly BMPR1B expressions were up-regulated during this differentiation. FGF2 inhibited HMSCs osteoblastic differentiation and the up-regulation of BMPs and BMPR. This effect was prevented by inhibiting the ERK or JNK mitogen-activated protein kinases which are known to be activated by FGF2. These data provide a mechanism explaining the inhibitory effect of FGF2 on osteoblastic differentiation of HMSCs. These crosstalks between growth and osteogenic factors should be considered in the use of recombinant BMPs in therapeutic purpose of fracture repair or skeletal bioengineering.

  7. Mapping bone changes at the proximal femoral cortex of postmenopausal women in response to alendronate and teriparatide alone, combined or sequentially

    E-Print Network [OSTI]

    Whitmarsh, Tristan; Treece, Graham M.; Gee, Andrew H.; Poole, Kenneth E. S.

    2015-06-15

    , it is important to bear in mind that TPTD has not been shown to prevent hip fracture in adequately powered clinical trials. Based on cost and clinical effectiveness, the National Institute for Health and Care Excellence (NICE) in the UK recommends ALN as a... depicts this at a simulated histological resolution (top panel, where new bone formed by teriparatide is shown in green). The lower two panels indicate what this process looks like to our cortical parameter measurements, with the first row of images...

  8. Ash Buddhas

    E-Print Network [OSTI]

    Hacker, Randi; Willis, Sheree; Tsutsui, William

    2006-11-08

    is the home of okotsubutsu, that is, statues of Buddha that are made entirely out of the ashes of the dearly departed. You heard that right. Since 1887, the cremated remains of many an ancestor have been formed into larger-than-life sized statues of Buddha...

  9. Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance

    SciTech Connect (OSTI)

    Mickisch, G.H.; Merlino, G.T.; Galski, H.; Gottesman, M.M.; Pastan, I. )

    1991-01-15

    The development of preclinical models for the rapid testing of agents that circumvent multidrug resistance in cancer is a high priority of research on drug resistance. A common form of multidrug resistance in human cancer results from expression of the MDR1 gene, which encodes a M{sub r} 170,000 glycoprotein that functions as a plasma membrane energy-dependent multidrug efflux pump. The authors have engineered transgenic mice that express this multidrug transporter in their bone marrow and demonstrated that these animals are resistant to leukopenia by a panel of anticancer drugs including anthracyclines, vinca alkaloids, etoposide, taxol, and actinomycin D. Differential leukocyte counts indicate that both neutrophils and lympohcytes are pretected. Drugs such as cisplatin, methotrexate, and 5-fluorouracil, which are not handled by the multidrug transporter, produce bone marrow suppression in both normal and transgenic mice. The resistance conferred by the MDR1 gene can be circumvented in a dose-dependent manner by simultaneous administration of agents previously shown to be inhibitors of the multidrug transporter in vitro, including verapamil isomers, quinidine, and quinine. They conclude that MDR1-transgenic mice provide a rapid and reliable system to determine the bioactivity of agents that reverse multidrug resistance in animals.

  10. Ashes of Home

    E-Print Network [OSTI]

    Ganaden, Evangeline Estolas

    2011-01-01

    sifting through belongings, ashes. 4. f/5.6 for the sun (wood carrying remnants of ash spilling prayers. Shoes left.OF CALIFORNIA RIVERSIDE Ashes of Home A Thesis submitted in

  11. A BALANCED DIPLOMACY TOURNAMENT ANDREW ASH, J. MARSHALL ASH

    E-Print Network [OSTI]

    Ash, J. Marshall

    A BALANCED DIPLOMACY TOURNAMENT ANDREW ASH, J. MARSHALL ASH , TIMOTHY L. MCMURRY, AND BRIDGETPaul University Faculty Summer Research Grants. 1 #12;2 A. ASH, J. M. ASH, T. L. MCMURRY, AND B. E. TENNER

  12. Randomized, Double-Blinded, Placebo-Controlled, Trial of Risedronate for the Prevention of Bone Mineral Density Loss in Nonmetastatic Prostate Cancer Patients Receiving Radiation Therapy Plus Androgen Deprivation Therapy

    SciTech Connect (OSTI)

    Choo, Richard [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States)] [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Lukka, Himu [Department of Radiation Oncology, Juravinski Cancer Center, McMaster University, Hamilton (Canada)] [Department of Radiation Oncology, Juravinski Cancer Center, McMaster University, Hamilton (Canada); Cheung, Patrick [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto (Canada); Corbett, Tom [Department of Radiation Oncology, Juravinski Cancer Center, McMaster University, Hamilton (Canada)] [Department of Radiation Oncology, Juravinski Cancer Center, McMaster University, Hamilton (Canada); Briones-Urbina, Rosario [Department of Medicine, Women's College Hospital, University of Toronto, Toronto (Canada)] [Department of Medicine, Women's College Hospital, University of Toronto, Toronto (Canada); Vieth, Reinhold [Departments of Nutritional Sciences and Laboratory Medicine and Pathology, Mount Sinai Hospital, University of Toronto, Toronto (Canada)] [Departments of Nutritional Sciences and Laboratory Medicine and Pathology, Mount Sinai Hospital, University of Toronto, Toronto (Canada); Ehrlich, Lisa [Department of Radiology, Sunnybrook Health Sciences Center, University of Toronto (Canada)] [Department of Radiology, Sunnybrook Health Sciences Center, University of Toronto (Canada); Kiss, Alex [Department of Health Policy, Management, and Evaluation, Sunnybrook Health Sciences Center, University of Toronto, Toronto (Canada)] [Department of Health Policy, Management, and Evaluation, Sunnybrook Health Sciences Center, University of Toronto, Toronto (Canada); Danjoux, Cyril, E-mail: Cyril.danjoux@sunnybrook.ca [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto (Canada)

    2013-04-01

    Purpose: Androgen deprivation therapy (ADT) has been used as an adjuvant treatment to radiation therapy (RT) for the management of locally advanced prostate carcinoma. Long-term ADT decreases bone mineral density (BMD) and increases the risk of osteoporosis. The objective of this clinical trial was to evaluate the efficacy of risedronate for the prevention of BMD loss in nonmetastatic prostate cancer patients undergoing RT plus 2 to 3 years of ADT. Methods and Materials: A double-blinded, placebo-controlled, randomized trial was conducted for nonmetastatic prostate cancer patients receiving RT plus 2 to 3 years of ADT. All had T scores > ?2.5 on dual energy x-ray absorptiometry at baseline. Patients were randomized 1:1 between risedronate and placebo for 2 years. The primary endpoints were the percent changes in the BMD of the lumbar spine at 1 and 2 years from baseline, measured by dual energy x-ray absorptiometry. Analyses of the changes in BMD and bone turnover biomarkers were carried out by comparing mean values of the intrapatient changes between the 2 arms, using standard t tests. Results: One hundred four patients were accrued between 2004 and 2007, with 52 in each arm. Mean age was 66.8 and 67.5 years for the placebo and risedronate, respectively. At 1 and 2 years, mean (±SE) BMD of the lumbar spine decreased by 5.77% ± 4.66% and 13.55% ± 6.33%, respectively, in the placebo, compared with 0.12% ± 1.29% at 1 year (P=.2485) and 0.85% ± 1.56% (P=.0583) at 2 years in the risedronate. The placebo had a significant increase in serum bone turnover biomarkers compared with the risedronate. Conclusions: Weekly oral risedronate prevented BMD loss at 2 years and resulted in significant suppression of bone turnover biomarkers for 24 months for patients receiving RT plus 2 to 3 years of ADT.

  13. Activation of fly ash

    DOE Patents [OSTI]

    Corbin, David R. (New Castle, DE); Velenyi, Louis J. (Lyndhurst, OH); Pepera, Marc A. (Northfield, OH); Dolhyj, Serge R. (Parma, OH)

    1986-01-01

    Fly ash is activated by heating a screened magnetic fraction of the ash in a steam atmosphere and then reducing, oxidizing and again reducing the hydrothermally treated fraction. The activated fly ash can be used as a carbon monoxide disproportionating catalyst useful in the production of hydrogen and methane.

  14. Activation of fly ash

    DOE Patents [OSTI]

    Corbin, D.R.; Velenyi, L.J.; Pepera, M.A.; Dolhyj, S.R.

    1986-08-19

    Fly ash is activated by heating a screened magnetic fraction of the ash in a steam atmosphere and then reducing, oxidizing and again reducing the hydrothermally treated fraction. The activated fly ash can be used as a carbon monoxide disproportionating catalyst useful in the production of hydrogen and methane.

  15. Ash utilisation This lecture

    E-Print Network [OSTI]

    Zevenhoven, Ron

    - and bottom ash Bottom ash ­ pH 10-11 ­ Poor lime effectiveness ­ Higher content Si and Al (sand) Fly ash ­ pH 12-13 ­ Good lime effectiveness ­ Higher content K and S (volatile) ­ Higher content heavy metals

  16. Fly ash carbon passivation

    DOE Patents [OSTI]

    La Count, Robert B; Baltrus, John P; Kern, Douglas G

    2013-05-14

    A thermal method to passivate the carbon and/or other components in fly ash significantly decreases adsorption. The passivated carbon remains in the fly ash. Heating the fly ash to about 500 and 800 degrees C. under inert gas conditions sharply decreases the amount of surfactant adsorbed by the fly ash recovered after thermal treatment despite the fact that the carbon content remains in the fly ash. Using oxygen and inert gas mixtures, the present invention shows that a thermal treatment to about 500 degrees C. also sharply decreases the surfactant adsorption of the recovered fly ash even though most of the carbon remains intact. Also, thermal treatment to about 800 degrees C. under these same oxidative conditions shows a sharp decrease in surfactant adsorption of the recovered fly ash due to the fact that the carbon has been removed. This experiment simulates the various "carbon burnout" methods and is not a claim in this method. The present invention provides a thermal method of deactivating high carbon fly ash toward adsorption of AEAs while retaining the fly ash carbon. The fly ash can be used, for example, as a partial Portland cement replacement in air-entrained concrete, in conductive and other concretes, and for other applications.

  17. Potential role of 20S proteasome in maintaining stem cell integrity of human bone marrow stromal cells in prolonged culture expansion

    SciTech Connect (OSTI)

    Lu, Li; Song, Hui-Fang; Zhang, Wei-Guo; Liu, Xue-Qin; Zhu, Qian; Cheng, Xiao-Long; Yang, Gui-Jiao; Li, Ang; Xiao, Zhi-Cheng; Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Melbourne 3800

    2012-05-25

    Highlights: Black-Right-Pointing-Pointer Prolonged culture expansion retards proliferation and induces senescence of hBMSCs. Black-Right-Pointing-Pointer Reduced 20S proteasomal activity and expression potentially contribute to cell aging. Black-Right-Pointing-Pointer MG132-mediated 20S proteasomal inhibition induces senescence-like phenotype. Black-Right-Pointing-Pointer 18{alpha}-GA stimulates proteasomal activity and restores replicative senescence. Black-Right-Pointing-Pointer 18{alpha}-GA retains differentiation without affecting stem cell characterizations. -- Abstract: Human bone marrow stromal cells (hBMSCs) could be used in clinics as precursors of multiple cell lineages following proper induction. Such application is impeded by their characteristically short lifespan, together with the increasing loss of proliferation capability and progressive reduction of differentiation potential after the prolonged culture expansion. In the current study, we addressed the possible role of 20S proteasomes in this process. Consistent with prior reports, long-term in vitro expansion of hBMSCs decreased cell proliferation and increased replicative senescence, accompanied by reduced activity and expression of the catalytic subunits PSMB5 and PSMB1, and the 20S proteasome overall. Application of the proteasome inhibitor MG132 produced a senescence-like phenotype in early passages, whereas treating late-passage cells with 18{alpha}-glycyrrhetinic acid (18{alpha}-GA), an agonist of 20S proteasomes, delayed the senescence progress, enhancing the proliferation and recovering the capability of differentiation. The data demonstrate that activation of 20S proteasomes assists in counteracting replicative senescence of hBMSCs expanded in vitro.

  18. L-type calcium channels play a crucial role in the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells

    SciTech Connect (OSTI)

    Wen, Li [Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an 710032 (China)] [Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an 710032 (China); Wang, Yu [Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032 (China)] [Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032 (China); Wang, Huan [Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an 710032 (China)] [Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an 710032 (China); Kong, Lingmin [Department of Fundamental Medicine, Cell Engineering Research Centre, Fourth Military Medical University, Xi'an 710032 (China)] [Department of Fundamental Medicine, Cell Engineering Research Centre, Fourth Military Medical University, Xi'an 710032 (China); Zhang, Liang [Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an 710032 (China)] [Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an 710032 (China); Chen, Xin [Department of General Dentistry, The 174th Hospital of Chinese PLA, Xiamen 361003 (China)] [Department of General Dentistry, The 174th Hospital of Chinese PLA, Xiamen 361003 (China); Ding, Yin, E-mail: dingyin@fmmu.edu.cn [Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an 710032 (China)] [Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an 710032 (China)

    2012-08-03

    Highlights: Black-Right-Pointing-Pointer We detect the functional Ca{sup 2+} currents and mRNA expression of VDCC{sub L} in rMSCs. Black-Right-Pointing-Pointer Blockage of VDCC{sub L} exert antiproliferative and apoptosis-inducing effects on rMSCs. Black-Right-Pointing-Pointer Inhibiting VDCC{sub L} can suppress the ability of rMSCs to differentiate into osteoblasts. Black-Right-Pointing-Pointer {alpha}1C of VDCC{sub L} may be a primary functional subunit in VDCC{sub L}-regulating rMSCs. -- Abstract: L-type voltage-dependent Ca{sup 2+} channels (VDCC{sub L}) play an important role in the maintenance of intracellular calcium homeostasis, and influence multiple cellular processes. They have been confirmed to contribute to the functional activities of osteoblasts. Recently, VDCC{sub L} expression was reported in mesenchymal stem cells (MSCs), but the role of VDCC{sub L} in MSCs is still undetermined. The aim of this study was to determine whether VDCC{sub L} may be regarded as a new regulator in the proliferation and osteogenic differentiation of rat MSC (rMSCs). In this study, we examined functional Ca{sup 2+} currents (I{sub Ca}) and mRNA expression of VDCC{sub L} in rMSCs, and then suppressed VDCC{sub L} using nifedipine (Nif), a VDCC{sub L} blocker, to investigate its role in rMSCs. The proliferation and osteogenic differentiation of MSCs were analyzed by MTT, flow cytometry, alkaline phosphatase (ALP), Alizarin Red S staining, RT-PCR, and real-time PCR assays. We found that Nif exerts antiproliferative and apoptosis-inducing effects on rMSCs. ALP activity and mineralized nodules were significantly decreased after Nif treatment. Moreover, the mRNA levels of the osteogenic markers, osteocalcin (OCN), bone sialoprotein (BSP), and runt-related transcription factor 2 (Runx2), were also down-regulated. In addition, we transfected {alpha}1C-siRNA into the cells to further confirm the role of VDCC{sub L} in rMSCs, and a similar effect on osteogenesis was found. These results suggest that VDCC{sub L} plays a crucial role in the proliferation and osteogenic differentiation of rMSCs.

  19. Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells

    SciTech Connect (OSTI)

    Tada, Hiroyuki [Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575 (Japan)] [Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575 (Japan); Nemoto, Eiji, E-mail: e-nemoto@umin.ac.jp [Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575 (Japan)] [Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575 (Japan); Kanaya, Sousuke; Hamaji, Nozomu; Sato, Hisae; Shimauchi, Hidetoshi [Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575 (Japan)] [Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575 (Japan)

    2010-04-16

    Dental pulp cells, which have been shown to share phenotypical features with osteoblasts, are capable of differentiating into odontoblast-like cells and generating a dentin-like mineral structure. Elevated extracellular Ca{sup 2+}Ca{sub o}{sup 2+} has been implicated in osteogenesis by stimulating the proliferation and differentiation of osteoblasts; however, the role of Ca{sub o}{sup 2+} signaling in odontogenesis remains unclear. We found that elevated Ca{sub o}{sup 2+} increases bone morphogenetic protein (BMP)-2 gene expression in human dental pulp cells. The increase was modulated not only at a transcriptional level but also at a post-transcriptional level, because treatment with Ca{sup 2+} increased the stability of BMP-2 mRNA in the presence of actinomycin D, an inhibitor of transcription. A similar increase in BMP-2 mRNA level was observed in other human mesenchymal cells from oral tissue; periodontal ligament cells and gingival fibroblasts. However, the latter cells exhibited considerably lower expression of BMP-2 mRNA compared with dental pulp cells and periodontal ligament cells. The BMP-2 increase was markedly inhibited by pretreatment with an extracellular signal-regulated kinase (ERK) inhibitor, PD98059, and partially inhibited by the L-type Ca{sup 2+} channels inhibitor, nifedipine. However, pretreatment with nifedipine had no effect on ERK1/2 phosphorylation triggered by Ca{sup 2+}, suggesting that the Ca{sup 2+} influx from Ca{sup 2+} channels may operate independently of ERK signaling. Dental pulp cells do not express the transcript of Ca{sup 2+}-sensing receptors (CaSR) and only respond slightly to other cations such as Sr{sup 2+} and spermine, suggesting that dental pulp cells respond to Ca{sub o}{sup 2+} to increase BMP-2 mRNA expression in a manner different from CaSR and rather specific for Ca{sub o}{sup 2+} among cations.

  20. Study on proliferative responses to host Ia antigens in allogeneic bone marrow chimera in mice: sequential analysis of the reactivity and characterization of the cells involved in the responses

    SciTech Connect (OSTI)

    Iwabuchi, K.; Ogasawara, K.; Ogasawara, M.; Yasumizu, R.; Noguchi, M.; Geng, L.; Fujita, M.; Good, R.A.; Onoe, K.

    1987-01-01

    Irradiation bone marrow chimeras were established by reconstitution of lethally irradiated AKR mice with C57BL/10 marrow cells to permit serial analysis of the developing reactivities of lymphocytes from such chimeras, (B10----AKR), against donor, host, or third party antigens. We found that substantial proliferative responses to Ia antigens of the recipient strain and also to third party antigens were generated by the thymocytes obtained from the irradiation chimeras at an early stage after bone marrow reconstitution. The majority of the responding thymocytes had surfaces lacking demonstrable peanut agglutinin receptors and were donor type Thy-1+, Ly-2-, and L3T4+ in both anti-recipient and anti-third party MLR. In anti-host responses, however, Ly-2+ thymocytes seemed to be at least partially involved. This capacity of thymus cells to mount a response to antigens of the recipient strain declined shortly thereafter, whereas the capacity to mount MLR against third party antigens persisted. The spleen cells of (B10----AKR) chimeras at the same time developed a more durable capability to exhibit anti-host reactivities and a permanent capability of reacting to third party allo-antigens. The stimulator antigens were Ia molecules on the stimulator cells in both anti-recipient and anti-third party MLR. The responding splenocytes were of donor origin and most of them had Thy-1+, Ly-1+2-, and L3T4+ phenotype.

  1. How tall is the White Ash tree? White Ash tree

    E-Print Network [OSTI]

    Ashline, George

    How tall is the White Ash tree? White Ash tree Sapling Activity Tree location Try this: · Measure the length of the White Ash's shadow on a nice sunny day. Place the end of your measuring tape at the base of the shadow. Record the length on your paper. · Next measure your shadow. Stand next to the White Ash and have

  2. Systemic atherosclerosis and bone density

    E-Print Network [OSTI]

    Hyder, Joseph Anthony

    2006-01-01

    K. Liu, J. C. Nelson, D. O'Leary, M. F. Saad, S. Shea, M.K. Liu, J. C. Nelson, D. O'Leary, M. F. Saad, S. Shea, M.J. W. MacCluer, D. H. O'Leary and B. D. Mitchell (2004). "

  3. Evaluation of Bone Fixation Implants 

    E-Print Network [OSTI]

    Perkins, Luke 1990-

    2012-12-10

    ......................................... 49 4.5.1.1. Anodic Polarization Scan ................................................... 50 4.5.1.2. Cathodic Polarization Scan ................................................. 51 4.5.2. Gamry Reference 600 Potentiostat Machine and Equipment . 51... movable image. .......................................................................................... 48 Figure 21. Theoretical anodic polarization scan of stainless steel [52]. ......................... 50 Figure 22. Theoretical cathodic...

  4. ASH SERVICE AWARD Summer 2015 Application

    E-Print Network [OSTI]

    Arnold, Jonathan

    ASH SERVICE AWARD Summer 2015 Application Katherine and Darren Ash established the Ash Service organization in Georgia, supporting programming that improves local communities. The two recipients of the Ash

  5. Modeling volcanic ash dispersal

    ScienceCinema (OSTI)

    None

    2011-10-06

    Explosive volcanic eruptions inject into the atmosphere large amounts of volcanic material (ash, blocks and lapilli). Blocks and larger lapilli follow ballistic and non-ballistic trajectories and fall rapidly close to the volcano. In contrast, very fine ashes can remain entrapped in the atmosphere for months to years, and may affect the global climate in the case of large eruptions. Particles having sizes between these two end-members remain airborne from hours to days and can cover wide areas downwind. Such volcanic fallout entails a serious threat to aircraft safety and can create many undesirable effects to the communities located around the volcano. The assessment of volcanic fallout hazard is an important scientific, economic, and political issue, especially in densely populated areas. From a scientific point of view, considerable progress has been made during the last two decades through the use of increasingly powerful computational models and capabilities. Nowadays, models are used to quantify hazard scenarios and/or to give short-term forecasts during emergency situations. This talk will be focused on the main aspects related to modeling volcanic ash dispersal and fallout with application to the well known problem created by the Eyjafjöll volcano in Iceland. Moreover, a short description of the main volcanic monitoring techniques is presented.

  6. Linearizing Mile Run Times Garrett I. Ash, J. Marshall Ash, and Stefan Catoiu

    E-Print Network [OSTI]

    Ash, J. Marshall

    Linearizing Mile Run Times Garrett I. Ash, J. Marshall Ash, and Stefan Catoiu Garrett Ash (gash1. He ran his most recent 1500-meter race in 247.5 seconds. J. Marshall Ash (mash

  7. Ash Recycling: Just a Dream ? Heiner Zwahr

    E-Print Network [OSTI]

    Columbia University

    Ash Recycling: Just a Dream ? Heiner Zwahr MVR Müllverwertung Rugenberger Damm GmbH & Co. KG, which started operation in 1896, it was stated that "the fly ash" collected in the ash chambers was used methods for analysing the ingredients of fly ash have been improved, we no longer use fly ash from waste

  8. Incineration and incinerator ash processing

    SciTech Connect (OSTI)

    Blum, T.W.

    1991-01-01

    Parallel small-scale studies on the dissolution and anion exchange recovery of plutonium from Rocky Flats Plant incinerator ash were conducted at the Los Alamos National Laboratory and at the Rocky Flats Plant. Results from these two studies are discussed in context with incinerator design considerations that might help to mitigate ash processing related problems. 11 refs., 1 fig., 1 tab.

  9. ON A CONJECTURE OF ASH ADRIAN BARBU

    E-Print Network [OSTI]

    Barbu, Adrian

    ON A CONJECTURE OF ASH ADRIAN BARBU THE OHIO STATE UNIVERSITY 2015 NEIL AVE., COLUMBUS, OH 43210, USA Abstract. In this paper we prove a particular case of a Conjecture of Ash that states.edu 1. Introduction In 1992, Professor Avner Ash made the following conjecture (see [Ash], p 242

  10. Emerald Ash Borer TEXAS TRAPPING PROJECT

    E-Print Network [OSTI]

    Emerald Ash Borer TEXAS TRAPPING PROJECT East Texas 2012 H. A. (Joe) Pase III Texas Forest Service Forest Health #12;#12;How To Identify Ash Trees Consider these quick points when identifying ash trees the EAB survey, ash trees do not need to be identified to species) Texas is home to at least six (6

  11. ITER helium ash accumulation

    SciTech Connect (OSTI)

    Hogan, J.T.; Hillis, D.L.; Galambos, J.; Uckan, N.A. ); Dippel, K.H.; Finken, K.H. . Inst. fuer Plasmaphysik); Hulse, R.A.; Budny, R.V. . Plasma Physics Lab.)

    1990-01-01

    Many studies have shown the importance of the ratio {upsilon}{sub He}/{upsilon}{sub E} in determining the level of He ash accumulation in future reactor systems. Results of the first tokamak He removal experiments have been analysed, and a first estimate of the ratio {upsilon}{sub He}/{upsilon}{sub E} to be expected for future reactor systems has been made. The experiments were carried out for neutral beam heated plasmas in the TEXTOR tokamak, at KFA/Julich. Helium was injected both as a short puff and continuously, and subsequently extracted with the Advanced Limiter Test-II pump limiter. The rate at which the He density decays has been determined with absolutely calibrated charge exchange spectroscopy, and compared with theoretical models, using the Multiple Impurity Species Transport (MIST) code. An analysis of energy confinement has been made with PPPL TRANSP code, to distinguish beam from thermal confinement, especially for low density cases. The ALT-II pump limiter system is found to exhaust the He with maximum exhaust efficiency (8 pumps) of {approximately}8%. We find 1<{upsilon}{sub He}/{upsilon}{sub E}<3.3 for the database of cases analysed to date. Analysis with the ITER TETRA systems code shows that these values would be adequate to achieve the required He concentration with the present ITER divertor He extraction system.

  12. Long duration ash probe

    DOE Patents [OSTI]

    Hurley, John P. (Grand Forks, ND); McCollor, Don P. (Grand Forks, ND); Selle, Stanley J. (Grand Forks, MN)

    1994-01-01

    A long duration ash probe includes a pressure shell connected to a port in a combustor with a sample coupon mounted on a retractable carriage so as to retract the sample coupon within the pressure shell during sootblowing operation of the combustor. A valve mounted at the forward end of the pressure shell is selectively closeable to seal the sample coupon within the shell, and a heating element in the shell is operable to maintain the desired temperature of the sample coupon while retracted within the shell. The carriage is operably mounted on a pair of rails within the shell for longitudinal movement within the shell. A hollow carrier tube connects the hollow cylindrical sample coupon to the carriage, and extends through the carriage and out the rearward end thereof. Air lines are connected to the rearward end of the carrier tube and are operable to permit coolant to pass through the air lines and thence through the carrier tube to the sample coupon so as to cool the sample coupon.

  13. Long duration ash probe

    DOE Patents [OSTI]

    Hurley, J.P.; McCollor, D.P.; Selle, S.J.

    1994-07-26

    A long duration ash probe includes a pressure shell connected to a port in a combustor with a sample coupon mounted on a retractable carriage so as to retract the sample coupon within the pressure shell during soot blowing operation of the combustor. A valve mounted at the forward end of the pressure shell is selectively closeable to seal the sample coupon within the shell, and a heating element in the shell is operable to maintain the desired temperature of the sample coupon while retracted within the shell. The carriage is operably mounted on a pair of rails within the shell for longitudinal movement within the shell. A hollow carrier tube connects the hollow cylindrical sample coupon to the carriage, and extends through the carriage and out the rearward end thereof. Air lines are connected to the rearward end of the carrier tube and are operable to permit coolant to pass through the air lines and thence through the carrier tube to the sample coupon so as to cool the sample coupon. 8 figs.

  14. Fly ash chemical classification based on lime

    SciTech Connect (OSTI)

    Fox, J.

    2007-07-01

    Typically, total lime content (CaO) of fly ash is shown in fly ash reports, but its significance is not addressed in US specifications. For certain applications a low lime ash is preferred. When a class C fly ash must be cementitious, lime content above 20% is required. A ternary S-A-C phase diagram pilot is given showing the location of fly ash compositions by coal rank and source in North America. Fly ashes from subbituminous coal from the Powder River Basin usually contain sufficient lime to be cementitious but blending with other coals may result in calcium being present in phases other than tricalcium aluminate. 9 refs., 1 fig.

  15. Rising from the ashes: Coal ash in recycling and construction

    SciTech Connect (OSTI)

    Naquin, D.

    1998-02-01

    Beneficial Ash Management (BAM, Clearfield, Pa.) has won an environmental award for its use of ash and other waste to fight acid mine drainage. The company`s workers take various waste materials, mainly fly ash from coal-burning plants, to make a cement-like material or grouting, says Ernest Roselli, BAM president. The grouting covers the soil, which helps prevent water from contacting materials. This, in turn, helps control chemical reactions, reducing or eliminating formation of acid mine drainage. The company is restoring the 1,400-acre Bark Camp coal mine site near Penfield in Clearfield County, Pa. Under a no-cost contract with the state of Pennsylvania, BAM is using boiler slag, causticizing byproducts (lime) and nonreclaimable clarifier sludge from International Paper Co. (Erie, Pa.). The mine reclamation techniques developed and monitored at the site include using man-made wetlands to treat acid mine drainage and testing anhydrous ammonia as a similar treatment agent. BAM researches and tests fly ash mixed with lime-based activators as fill material for land reclamation, and develops and uses artificial soil material from paper mill and tannery biosolids.

  16. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of glass scaffolds, including polymer foam replication, sol-gel, and freeze-casting; however, the low compressive strength of these scaffolds (0.2-28 MPa for porosity of...

  17. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have...

  18. Composite bone substitutes prepared by two methods

    E-Print Network [OSTI]

    Lee, Hoe Yun; Lee, Hoe Yun

    2012-01-01

    P. Zeng, “Effects of gelatin addition on the microstructureP. Zeng, “Effects of gelatin addition on the microstructureconcentrations of gelatin. (a) 0 wt. %, (b) 2 wt. %, and (c)

  19. Composite bone substitutes prepared by two methods

    E-Print Network [OSTI]

    Lee, Hoe Yun; Lee, Hoe Yun

    2012-01-01

    of copper cold finger, PTFE mold, and copper lid. .. 41A dimensioned drawing of the PTFE mold, copper lid, and coldpolytetrafluoroethylene (PTFE) mold which was then set atop

  20. Effects of osteoporosis therapies on bone biomechanics

    E-Print Network [OSTI]

    Easley, Sarah Kathleen

    2010-01-01

    Keaveny TM. Orthopaedic biomechanics: Mechanics and designCR, Sances A. Functional biomechanics of the thoracolumbarstiffness. Journal of Biomechanics 1998;31: 1009-15. [96

  1. Mandible versus Long Bone Marrow Cells

    E-Print Network [OSTI]

    Chaichanasakul, Thawinee

    2012-01-01

    et al. 1989; Lerner 2006; Mavropoulos et al. 2007). However,the proximal tibia (Mavropoulos et al. 2007). In addition,during mastication (Mavropoulos et al. 2004). In fact,

  2. ACR Appropriateness Criteria® on Metastatic Bone Disease

    E-Print Network [OSTI]

    2010-01-01

    when 89 Sr treat- ment is being considered. Vertebral ColumnThe vertebral column deserves special consideration. It is

  3. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O OLaura|Bilayer Graphene Gets aVehicles andIndustrialBioactive

  4. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O OLaura|Bilayer Graphene Gets aVehicles

  5. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O OLaura|Bilayer Graphene Gets aVehiclesBioactive Glass

  6. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O OLaura|Bilayer Graphene Gets aVehiclesBioactive

  7. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O OLaura|Bilayer Graphene Gets aVehiclesBioactiveBioactive

  8. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAudits & InspectionsBeryllium andSampler As An Alternative Monitoring

  9. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAudits & InspectionsBeryllium andSampler As An Alternative

  10. Bioactive Glass Scaffolds for Bone Regeneration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAudits & InspectionsBeryllium andSampler As An AlternativeBioactive Glass

  11. The volcanic ash problem Bernd Zimanowski a;

    E-Print Network [OSTI]

    The volcanic ash problem Bernd Zimanowski a;Ã , Kenneth Wohletz b , Pierfrancesco Dellino c , Ralf are the result of intensive magma and rock fragmentation, and they produce volcanic ash, which consists of fragments 6 2 mm in average diameter. The problem with volcanic ash is that its formation is poorly

  12. Let's makeleaf people! White Ash tree

    E-Print Network [OSTI]

    Ashline, George

    Let's makeleaf people! White Ash tree Seedling Activity Tree location Let's start by exploring the leaf of the White Ash tree! Can you describe the leaf? Does it have smooth-edges or rough-edges? What of anything? Try this... Let's create leaf people from the shape of the White Ash leaves. The shape

  13. A comparison between sludge ash and fly ash on the improvement in soft soil

    SciTech Connect (OSTI)

    Deng-Fong Lin; Kae-Long Lin; Huan-Lin Luo

    2007-01-15

    In this study, the strength of soft cohesive subgrade soil was improved by applying sewage sludge ash as a soil stabilizer. Test results obtained were compared with earlier tests conducted on soil samples treated with fly ash. Five different proportions of sludge ash and fly ash were mixed with soft cohesive soil, and tests such as pH value, compaction, California bearing ratio, unconfined compressive strength (UCS), and triaxial compression were performed to understand soil strength improvement because of the addition of both ashes. Results indicate that pH values increase with extending curing age for soil with sludge ash added. The UCS of sludge ash/soil were 1.4 2 times better than untreated soil. However, compressive strength of sludge ash/soil was 20 30 kPa less than fly ash/soil. The bearing capacities for both fly ash/soil and sludge ash/soil were five to six times and four times, respectively, higher than the original capacity. Moreover, the cohesive parameter of shear strength rose with increased amounts of either ash added. Friction angle, however, decreased with increased amounts of either ash. Consequently, results show that sewage sludge ash can potentially replace fly ash in the improvement of the soft cohesive soil. 9 refs., 5 figs., 2 tabs.

  14. Petrographic characterization of economizer fly ash

    SciTech Connect (OSTI)

    Valentim, B.; Hower, J.C.; Soares, S.; Guedes, A.; Garcia, C.; Flores, D.; Oliveira, A.

    2009-11-15

    Policies for reducing NOx emissions have led power plants to restrict O{sub 2}, resulting in high-carbon fly ash production. Therefore, some potentially useful fly ash, such as the economizer fly ash, is discarded without a thorough knowledge of its composition. In order to characterize this type of fly ash, samples were collected from the economizer Portuguese power plant burning two low-sulfur bituminous coals. Characterization was also performed on economizer fly ash subsamples after wet sieving, density and magnetic separation. Analysis included atomic absorption spectroscopy, loss-on-ignition, scanning electron microscopy/energy-dispersive X-ray spectroscopy, optical microscopy, and micro-Raman spectroscopy.

  15. ACAA fly ash basics: quick reference card

    SciTech Connect (OSTI)

    2006-07-01

    Fly ash is a fine powdery material created when coal is burned to generate electricity. Before escaping into the environment via the utility stacks, the ash is collected and may be stored for beneficial uses or disposed of, if necessary. The use of fly ash provides environmental benefits, such as the conservation of natural resources, the reduction of greenhouse gas emissions and eliminating the needed for ash disposal in landfills. It is also a valuable mineral resource that is used in construction and manufacturing. Fly ash is used in the production of Portland cement, concrete, mortars and stuccos, manufactured aggregates along with various agricultural applications. As mineral filler, fly ash can be used for paints, shingles, carpet backing, plastics, metal castings and other purposes. This quick reference card is intended to provide the reader basic source, identification and composition, information specifically related to fly ash.

  16. Evaluation of vitrifying municipal incinerator ash

    SciTech Connect (OSTI)

    Chapman, C.C.

    1991-04-01

    The management of municipal solid waste (MSW) is becoming a national problem. Landfills are being closed and new landfills are not projected to meet future needs. Incineration provides significant volume reduction of MSW, but the resulting ash can concentrate undesirable organics and heavy metals. Vitrification of ash is a very attractive means for treating this ash stream. It provides further volume reduction, destroys any organic residues, and immobilizes heavy metals. In addition, the vitrified ash can become a useful construction material. Thus, vitrification can transform a waste material into a useful product and without requiring and landfill capacity. The feasibility of vitrifying MSW incinerator ash produced by an existing incineration facility in Whatcom County, Washington, was evaluated technically and economically. Vitrification of the incinerator ash provides an 80 volume percent reduction, forms a homogeneous glass, and is estimated to be economically favored over transportation and disposal of ash for the Whatcom County site by over $25 dollars per ton of ash. The vitrification cost per ton of ash is about $53. When assigned to the original ton of MSW, the vitrification cost is about $20 dollars per ton of MSW. Thus, vitrification of MSW incinerator ash provides an economic treatment method while providing an environmentally sound solution to another potentially troublesome waste stream. 4 refs., 4 figs., 5 tabs.

  17. Combustion with reduced carbon in the ash

    DOE Patents [OSTI]

    Kobayashi, Hisashi; Bool, III, Lawrence E.

    2005-12-27

    Combustion of coal in which oxygen is injected into the coal as it emerges from burner produces ash having reduced amounts of carbon.

  18. Untreated ash trees after EAB peak, Belvedere Dr., Toledo, OH, June 2009. Coalition for Urban Ash Tree Conservation

    E-Print Network [OSTI]

    Aukema, Brian

    Untreated ash trees after EAB peak, Belvedere Dr., Toledo, OH, June 2009. Coalition for Urban Ash Tree Conservation - Emerald Ash Borer Management Statement - www.emeraldashborer.info/files/conserve_ash.pdf signed 06 Jan 2011 We the undersigned strongly endorse ash tree conservation as a fundamental component

  19. Characterization of ash cenospheres in fly ash from Australian power stations

    SciTech Connect (OSTI)

    Ling-ngee Ngu; Hongwei Wu; Dong-ke Zhang

    2007-12-15

    Ash cenospheres in fly ashes from five Australian power stations have been characterized. The experimental data show that ash cenosphere yield varies across the power stations. Ash partitioning occurred in the process of ash cenosphere formation during combustion. Contradictory to conclusions from the literature, iron does not seem to be essential to ash cenosphere formation in the cases examined in the present work. Further investigation was also undertaken on a series of size-fractioned ash cenosphere samples from Tarong power station. It is found that about 70 wt% of ash cenospheres in the bulk sample have sizes between 45 and 150 {mu}m. There are two different ash cenosphere structures, that is, single-ring structure and network structure. The percentage of ash cenospheres of a network structure increases with increasing ash cenosphere size. Small ash cenospheres (in the size fractions {lt}150 {mu}m) have a high SiO{sub 2}/Al{sub 2}O{sub 3} ratio, and the majority of the ash cenospheres are spherical and of a single-ring structure. Large ash cenosphere particles (in the size fractions of 150-250 {mu}m and {gt}250 {mu}m) have a low SiO{sub 2}/Al{sub 2}O{sub 3} ratio, and a high proportion of the ash cenospheres are nonspherical and of a network structure. A novel quantitative technique has been developed to measure the diameter and wall thickness of ash cenospheres on a particle-to-particle basis. A monolayer of size-fractioned ash cenospheres was dispersed on a pellet, which was then polished carefully before being examined using a scanning electron microscope and image analysis. The ash cenosphere wall thickness broadly increases with increasing ash cenosphere size. The ratios between wall thickness and diameter of ash cenospheres are limited between an upper bound of about 10.5% and a lower bound of about 2.5%, irrespective of the ash cenosphere size. 52 refs., 9 figs., 4 tabs.

  20. Treatment of fly ash for use in concrete

    DOE Patents [OSTI]

    Boxley, Chett (Park City, UT)

    2012-05-15

    A process for treating fly ash to render it highly usable as a concrete additive. A quantity of fly ash is obtained that contains carbon and which is considered unusable fly ash for concrete based upon foam index testing. The fly ash is mixed with a quantity of spray dryer ash (SDA) and water to initiate a geopolymerization reaction and form a geopolymerized fly ash. The geopolymerized fly ash is granulated. The geopolymerized fly ash is considered usable fly ash for concrete according to foam index testing. The geopolymerized fly ash may have a foam index less than 40%, and in some cases less than 20%, of the foam index of the untreated fly ash. An optional alkaline activator may be mixed with the fly ash and SDA to facilitate the geopolymerization reaction. The alkaline activator may contain an alkali metal hydroxide, carbonate, silicate, aluminate, or mixtures thereof.

  1. Bone Mineral Density, Bone Turnover, and Systemic Inflammation in Non-cirrhotics with Chronic Hepatitis C

    E-Print Network [OSTI]

    Lai, JC; Shoback, DM; Zipperstein, J; Lizaola, B; Tseng, S; Terrault, NA

    2015-01-01

    KP, Ludwig J. Chronic hepatitis. An update on terminologyet al. The prevalence of hepatitis C virus infection in thetransplantation for viral hepatitis in the United States.

  2. Bone Mineral Density, Bone Turnover, and Systemic Inflammation in Non-cirrhotics with Chronic Hepatitis C

    E-Print Network [OSTI]

    Lai, JC; Shoback, DM; Zipperstein, J; Lizaola, B; Tseng, S; Terrault, NA

    2015-01-01

    non- cirrhotic chronic hepatitis B or C infection. World Jtransplantation for viral hepatitis in the United States.liver disease caused by hepatitis C and alcoholic liver

  3. Reducing Lubricant Ash Impact on Exhaust Aftertreatment with...

    Energy Savers [EERE]

    Reducing Lubricant Ash Impact on Exhaust Aftertreatment with a Oil Conditioning Filter Reducing Lubricant Ash Impact on Exhaust Aftertreatment with a Oil Conditioning Filter Under...

  4. Impact of Biodiesel on Ash Emissions and Lubricant Properties...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Biodiesel on Ash Emissions and Lubricant Properties Affecting Fuel Economy and Engine Wear Impact of Biodiesel on Ash Emissions and Lubricant Properties Affecting Fuel Economy and...

  5. Minimizing Lubricant-Ash Requirement and Impact on Emission Aftertreat...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Minimizing Lubricant-Ash Requirement and Impact on Emission Aftertreatment Systems via an Oil Conditioning Filter Minimizing Lubricant-Ash Requirement and Impact on Emission...

  6. Uncovering Fundamental Ash-Formation Mechanisms and Potential...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Uncovering Fundamental Ash-Formation Mechanisms and Potential Means to Control the Impact on DPF Performance and Engine Efficiency Uncovering Fundamental Ash-Formation Mechanisms...

  7. The Development of a Small Engine Based Accelerated Ash Loading...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Accelerated Ash Loading Protocol The Development of a Small Engine Based Accelerated Ash Loading Protocol Presentation given at DEER 2006, August 20-24, 2006, Detroit, Michigan....

  8. Detailed Characterization of Lubricant-Derived Ash-Related Species...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Characterization of Lubricant-Derived Ash-Related Species in Diesel Exhaust and Aftertreatment Systems Detailed Characterization of Lubricant-Derived Ash-Related Species in Diesel...

  9. Development of an Accelerated Ash-Loading Protocol for Diesel...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    an Accelerated Ash-Loading Protocol for Diesel Particulate Filters Development of an Accelerated Ash-Loading Protocol for Diesel Particulate Filters Poster presentation at the 2007...

  10. Treatment of fly ash for use in concrete

    DOE Patents [OSTI]

    Boxley, Chett (Park City, UT); Akash, Akash (Salt lake City, UT); Zhao, Qiang (Natick, MA)

    2012-05-08

    A process for treating fly ash to render it highly usable as a concrete additive. A quantity of fly ash is obtained that contains carbon and which is considered unusable fly ash for concrete based upon foam index testing. The fly ash is mixed with an activator solution sufficient to initiate a geopolymerization reaction and for a geopolymerized fly ash. The geopolymerized fly ash is granulated. The geopolymerized fly ash is considered usable fly ash for concrete according to foam index testing. The geopolymerized fly ash may have a foam index less than 35% of the foam index of the untreated fly ash, and in some cases less than 10% of the foam index of the untreated fly ash. The activator solution may contain an alkali metal hydroxide, carbonate, silicate, aluminate, or mixtures thereof.

  11. Treatment of fly ash for use in concrete

    DOE Patents [OSTI]

    Boxley, Chett; Akash, Akash; Zhao, Qiang

    2013-01-08

    A process for treating fly ash to render it highly usable as a concrete additive. A quantity of fly ash is obtained that contains carbon and which is considered unusable fly ash for concrete based upon foam index testing. The fly ash is mixed with an activator solution sufficient to initiate a geopolymerization reaction and for a geopolymerized fly ash. The geopolymerized fly ash is granulated. The geopolymerized fly ash is considered usable fly ash for concrete according to foam index testing. The geopolymerized fly ash may have a foam index less than 35% of the foam index of the untreated fly ash, and in some cases less than 10% of the foam index of the untreated fly ash. The activator solution may contain an alkali metal hydroxide, carbonate, silicate, aluminate, or mixtures thereof.

  12. Rocky Flats ash test procedure (sludge stabilization)

    SciTech Connect (OSTI)

    Winstead, M.L.

    1995-09-14

    Rocky Flats Ash items have been identified as the next set of materials to be stabilized. This test is being run to determine charge sizes and soak times to completely stabilize the Rocky Flats Ash items. The information gathered will be used to generate the heating rampup cycle for stabilization. This test will also gain information on the effects of the glovebox atmosphere (moisture) on the stabilized material. This document provides instructions for testing Rocky Flats Ash in the HC-21C muffle furnace process.

  13. Measurement of the Optical Proper-ties of Volcanic Ash

    E-Print Network [OSTI]

    Oxford, University of

    Measurement of the Optical Proper- ties of Volcanic Ash Daniel M. Peters and R. G. Grainger of Volcanic Ash". This project will measure vol- canic ash aerosol extinction spectra and the aerosol particle is required in the analysis of IR satellite observations of ash clouds. Dry, water ice and sulphuric acid

  14. Optical properties of volcanic ash Dan M. Peters1

    E-Print Network [OSTI]

    Oxford, University of

    Optical properties of volcanic ash Dan M. Peters1 , Roy G. Grainger1 , Robert McPheat2 , Ben Reed1 volcanic ash clouds remotely. Current meth- ods of detection use wavelengths from the UV to infra-red both of the ash. As ash composition varies from eruption to eruption the refractive index also differs; our aim

  15. Honorary Doctor of Science Sir Eric Albert ASH

    E-Print Network [OSTI]

    Po, Lai-Man

    Honorary Doctor of Science Sir Eric Albert ASH Chancellor: Sir Eric Albert Ash attended is meeting Clare, his wife, who was a graduate student at Stanford at that time. We are honoured that Mrs Ash of the University Council, I request you to confer on Sir Eric Albert Ash the Honorary Degree of Doctor of Science

  16. Mass loading estimates of the Eyjafjll ash plume using principle

    E-Print Network [OSTI]

    Graaf, Martin de

    Mass loading estimates of the Eyjafjöll ash plume using principle component analysis applied;Tropospheric aerosol kernels #12;Volcanic ash refractive index El Chicón ash: 1.53 (PaNerson et Eyjafjöll volcanic ash mass concentrations were low over NL PCA and multi-wavelength data may help to find

  17. Fly ash system technology improves opacity

    SciTech Connect (OSTI)

    2007-06-15

    Unit 3 of the Dave Johnston Power Plant east of Glenrock, WY, USA had problems staying at or below the opacity limits set by the state. The unit makes use of a Lodge Cottrell precipitator. When the plant changed to burning Power River Basin coal, ash buildup became a significant issue as the fly ash control system was unable to properly evacuate hoppers on the unit. To overcome the problem, the PLC on the unit was replaced with a software optimization package called SmartAsh for the precipitator fly ash control system, at a cost of $500,000. After the upgrade, there have been no plugged hoppers and the opacity has been reduced from around 20% to 3-5%. 2 figs.

  18. Rocky Flats Ash test procedure (sludge stabilization)

    SciTech Connect (OSTI)

    Funston, G.A.

    1995-06-14

    Rocky Flats Ash items have been identified as the next set of materials to be stabilized. This test is being run to determine charge sizes and soak times to completely stabilize the Rocky Flats Ash items. The information gathered will be used to generate the heating rampup cycle for stabilization. The test will provide information to determine charge sizes, soak times and mesh screen sizes (if available at time of test) for stabilization of Rocky Flats Ash items to be processed in the HC-21C Muffle Furnace Process. Once the charge size and soak times have been established, a program for the temperature controller of the HC-21C Muffle Furnace process will be generated for processing Rocky Flats Ash.

  19. Fluidized bed gasification ash reduction and removal system

    DOE Patents [OSTI]

    Schenone, Carl E. (Madison, PA); Rosinski, Joseph (Vanderbilt, PA)

    1984-02-28

    In a fluidized bed gasification system an ash removal system to reduce the particulate ash to a maximum size or smaller, allow the ash to cool to a temperature lower than the gasifier and remove the ash from the gasifier system. The system consists of a crusher, a container containing level probes and a means for controlling the rotational speed of the crusher based on the level of ash within the container.

  20. Fluidized bed gasification ash reduction and removal process

    DOE Patents [OSTI]

    Schenone, Carl E. (Madison, PA); Rosinski, Joseph (Vanderbilt, PA)

    1984-12-04

    In a fluidized bed gasification system an ash removal system to reduce the particulate ash to a maximum size or smaller, allow the ash to cool to a temperature lower than the gasifier and remove the ash from the gasifier system. The system consists of a crusher, a container containing level probes and a means for controlling the rotational speed of the crusher based on the level of ash within the container.

  1. Flue gas desulfurization gypsum and fly ash

    SciTech Connect (OSTI)

    Not Available

    1992-05-01

    The Cumberland Fossil Plant (CUF) is located in Stewart County, Tennessee, and began commercial operation in 1972. This is the Tennessee Valley Authority`s newest fossil (coal-burning) steam electric generating plant. Under current operating conditions, the plant burns approximately seven million tons of coal annually. By-products from the combustion of coal are fly ash, approximately 428,000 tons annually, and bottom ash, approximately 115,000 tons annually. Based on historical load and projected ash production rates, a study was initially undertaken to identify feasible alternatives for marketing, utilization and disposal of ash by-products. The preferred alternative to ensure that facilities are planned for all by-products which will potentially be generated at CUF is to plan facilities to handle wet FGD gypsum and dry fly ash. A number of different sites were evaluated for their suitability for development as FGD gypsum and ash storage facilities. LAW Engineering was contracted to conduct onsite explorations of sites to develop information on the general mature of subsurface soil, rock and groundwater conditions in the site areas. Surveys were also conducted on each site to assess the presence of endangered and threatened species, wetlands and floodplains, archaeological and cultural resources, prime farmland and other site characteristics which must be considered from an environmental perspective.

  2. Comparative study on the characteristics of fly ash and bottom ash geopolymers

    SciTech Connect (OSTI)

    Chindaprasirt, Prinya; Jaturapitakkul, Chai; Chalee, Wichian; Rattanasak, Ubolluk

    2009-02-15

    This research was conducted to compare geopolymers made from fly ash and ground bottom ash. Sodium hydroxide (NaOH) and sodium silicate (Na{sub 2}SiO{sub 3}) solutions were used as activators. A mass ratio of 1.5 Na{sub 2}SiO{sub 3}/NaOH and three concentrations of NaOH (5, 10, and 15 M) were used; the geopolymers were cured at 65 deg. C for 48 h. A Fourier transform infrared spectrometer (FT-IR), differential scanning calorimeter (DSC), and scanning electron microscope (SEM) were used on the geopolymer pastes. Geopolymer mortars were also prepared in order to investigate compressive strength. The results show that both fly ash and bottom ash can be utilized as source materials for the production of geopolymers. The properties of the geopolymers are dependent on source materials and the NaOH concentration. Fly ash is more reactive and produces a higher degree of geopolymerization in comparison with bottom ash. The moderate NaOH concentration of 10 M is found to be suitable and gives fly ash and bottom ash geopolymer mortars with compressive strengths of 35 and 18 MPa.

  3. Scale-Up and Demonstration of Fly Ash Ozonation Technology

    SciTech Connect (OSTI)

    Rui Afonso; R. Hurt; I. Kulaots

    2006-03-01

    The disposal of fly ash from the combustion of coal has become increasingly important. When the fly ash does not meet the required specification for the product or market intended, it is necessary to beneficiate it to achieve the desired quality. This project, conducted at PPL's Montour SES, is the first near full-scale ({approx}10 ton/day), demonstration of ash ozonation technology. Bituminous and sub bituminous ashes, including two ash samples that contained activated carbon, were treated during the project. Results from the tests were very promising. The ashes were successfully treated with ozone, yielding concrete-suitable ash quality. Preliminary process cost estimates indicate that capital and operating costs to treat unburned carbon are competitive with other commercial ash beneficiation technologies at a fraction of the cost of lost sales and/or ash disposal costs. This is the final technical report under DOE Cooperative Agreement No.: DE-FC26-03NT41730.

  4. Hydrothermal reaction of fly ash. Final report

    SciTech Connect (OSTI)

    Brown, P.W.

    1994-12-31

    The reactions which occur when fly ash is treated under hydrothermal conditions were investigated. This was done for the following primary reasons. The first of these is to determine the nature of the phases that form to assess the stabilities of these phases in the ambient environment and, finally, to assess whether these phases are capable of sequestering hazardous species. The second reason for undertaking this study was whether, depending on the composition of the ash and the presence of selected additives, it would be possible under hydrothermal conditions to form compounds which have cementitious properties. Formation of four classes of compounds, which bracket likely fly ash compositional ranges, were selected for study. The classes are calcium silicate hydrates, calcium selenates, and calcium aluminosulfates, and silicate-based glasses. Specific compounds synthesized were determined and their stability regions assessed. As part of stability assessment, the extent to which selected hazardous species are sequestered was determined. Finally, the cementing properties of these compounds were established. The results obtained in this program have demonstrated that mild hydrothermal conditions can be employed to improve the reactivity of fly ash. Such improvements in reactivity can result in the formation of monolithic forms which may exhibit suitable mechanical properties for selected applications as building materials. If the ashes involved are considered hazardous, the mechanical properties exhibited indicated the forms could be handled in a manner which facilitates their disposal.

  5. Extraction of trace metals from fly ash

    DOE Patents [OSTI]

    Blander, Milton (Palos Park, IL); Wai, Chien M. (Moscow, ID); Nagy, Zoltan (Woodridge, IL)

    1984-01-01

    A process for recovering silver, gallium and/or other trace metals from a fine grained industrial fly ash associated with a process for producing phosphorous, the fly ash having a silicate base and containing surface deposits of the trace metals as oxides, chlorides or the like, with the process being carried out by contacting the fly ash with AlCl.sub.3 in an alkali halide melt to react the trace metals with the AlCl.sub.3 to form compositions soluble in the melt and a residue containing the silicate and aluminum oxide or other aluminum precipitate, and separating the desired trace metal or metals from the melt by electrolysis or other separation techniques.

  6. Extraction of trace metals from fly ash

    DOE Patents [OSTI]

    Blander, M.; Wai, C.M.; Nagy, Z.

    1983-08-15

    A process is described for recovering silver, gallium and/or other trace metals from a fine grained industrial fly ash associated with a process for producing phosphorous. The fly ash has a silicate base and contains surface deposits of the trace metals as oxides, chlorides or the like. The process is carried out by contacting the fly ash with AlCl/sub 3/ in an alkali halide melt to react the trace metals with the AlCl/sub 3/ to form compositions soluble in the melt and a residue containing the silicate and aluminum oxide or other aluminum precipitate, and separating the desired trace metal or metals from the melt by electrolysis or other separation techniques.

  7. Arsenic remediation of drinking water using iron-oxide coated coal bottom ash

    E-Print Network [OSTI]

    MATHIEU, JOHANNA L.

    2010-01-01

    from aqueous solutions by fly ash. Water Res. 1993, 27(12),of Cations in Class F Fly Ash. Environ. Sci. Technol. 2003,ash particles become fly ash. A maximum ARUBA diameter size

  8. Using fly ash to mitigate explosions

    SciTech Connect (OSTI)

    Taulbee, D.

    2008-07-01

    In 2005 the University of Kentucky's Center for Applied Energy Research was given funding to evaluate the use of coal combustion by-products (CCBs) to reduce the explosive potential of ammonium nitrate (AN) fertilizers. Fly ash C (FAC), fly ash F (FAF) and flue gas desulfurization by-product (FGD) were evaluated. It was found that applying a CCB coating to the AN particles at concentrations of 5 wt% or greater prevented the AN explosion from propagating. The article reports on results so far and outlines further work to be done. 6 figs.

  9. Fly Ash Characteristics and Carbon Sequestration Potential

    SciTech Connect (OSTI)

    Palumbo, Anthony V.; Amonette, James E.; Tarver, Jana R.; Fagan, Lisa A.; McNeilly, Meghan S.; Daniels, William L.

    2007-07-20

    Concerns for the effects of global warming have lead to an interest in the potential for inexpensive methods to sequester carbon dioxide (CO2). One of the proposed methods is the sequestration of carbon in soil though the growth of crops or forests.4,6 If there is an economic value placed on sequestration of carbon dioxide in soil there may be an an opportunity and funding to utilize fly ash in the reclamation of mine soils and other degraded lands. However, concerns associated with the use of fly ash must be addressed before this practice can be widely adopted. There is a vast extent of degraded lands across the world that has some degree of potential for use in carbon sequestration. Degraded lands comprise nearly 2 X 109 ha of land throughout the world.7 Although the potential is obviously smaller in the United States, there are still approximately 4 X 106 ha of degraded lands that previously resulted from mining operations14 and an additional 1.4 X 108 ha of poorly managed lands. Thus, according to Lal and others the potential is to sequester approximately 11 Pg of carbon over the next 50 years.1,10 The realization of this potential will likely be dependent on economic incentives and the use of soil amendments such as fly ash. There are many potential benefits documented for the use of fly ash as a soil amendment. For example, fly ash has been shown to increase porosity, water-holding capacity, pH, conductivity, and dissolved SO42-, CO32-, HCO3-, Cl- and basic cations, although some effects are notably decreased in high-clay soils.8,13,9 The potential is that these effects will promote increased growth of plants (either trees or grasses) and result in greater carbon accumulation in the soil than in untreated degraded soils. This paper addresses the potential for carbon sequestration in soils amended with fly ash and examines some of the issues that should be considered in planning this option. We describe retrospective studies of soil carbon accumulation on reclaimed mine lands, leaching studies of fly ash and carbon sorption studies of fly ash.

  10. High Carbon Fly Ash Treatment | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High Carbon Fly Ash Treatment NETL Collaborators Invent Method for Treating High Carbon Fly Ash The U.S. Patent and Trademark Office has assigned Patent No. 8,440,015 to...

  11. High carbon fly ash finds uses in highway construction

    SciTech Connect (OSTI)

    Wen, H.; Patton, R.

    2008-07-01

    The beneficial use of high carbon fly ash in a highway construction project is discussed. The fly ash also had a relatively high content of mercury and some other heavy metals. 1 fig., 4 photos.

  12. Eco-friendly fly ash utilization: potential for land application

    SciTech Connect (OSTI)

    Malik, A.; Thapliyal, A.

    2009-07-01

    The increase in demand for power in domestic, agricultural, and industrial sectors has increased the pressure on coal combustion and aggravated the problem of fly ash generation/disposal. Consequently the research targeting effective utilization of fly ash has also gained momentum. Fly ash has proved to be an economical substitute for expensive adsorbents as well as a suitable raw material for brick manufacturing, zeolite synthesis, etc. Fly ash is a reservoir of essential minerals but is deficient in nitrogen and phosphorus. By amending fly ash with soil and/or various organic materials (sewage sludge, bioprocess materials) as well as microbial inoculants like mycorrhizae, enhanced plant growth can be realized. Based on the sound results of large scale studies, fly ash utilization has grown into prominent discipline supported by various internationally renowned organizations. This paper reviews attempts directed toward various utilization of fly ash, with an emphasis on land application of organic/microbial inoculants amended fly ash.

  13. Utilization of blended fluidized bed combustion (FBC) ash and pulverized coal combustion (PCC) fly ash in geopolymer

    SciTech Connect (OSTI)

    Chindaprasirt, Prinya; Rattanasak, Ubolluk

    2010-04-15

    In this paper, synthesis of geopolymer from fluidized bed combustion (FBC) ash and pulverized coal combustion (PCC) fly ash was studied in order to effectively utilize both ashes. FBC-fly ash and bottom ash were inter-ground to three different finenesses. The ashes were mixed with as-received PCC-fly ash in various proportions and used as source material for synthesis of geopolymer. Sodium silicate (Na{sub 2}SiO{sub 3}) and 10 M sodium hydroxide (NaOH) solutions at mass ratio of Na{sub 2}SiO{sub 3}/NaOH of 1.5 and curing temperature of 65 deg. C for 48 h were used for making geopolymer. X-ray diffraction (XRD), scanning electron microscopy (SEM), degree of reaction, and thermal gravimetric analysis (TGA) were performed on the geopolymer pastes. Compressive strength was also tested on geopolymer mortars. The results show that high strength geopolymer mortars of 35.0-44.0 MPa can be produced using mixture of ground FBC ash and as-received PCC-fly ash. Fine FBC ash is more reactive and results in higher degree of reaction and higher strength geopolymer as compared to the use of coarser FBC ash. Grinding increases reactivity of ash by means of increasing surface area and the amount of reactive phase of the ash. In addition, the packing effect due to fine particles also contributed to increase in strength of geopolymers.

  14. Utilization of CFB fly ash for construction applications

    SciTech Connect (OSTI)

    Conn, R.E.; Sellakumar, K.; Bland, A.E.

    1999-07-01

    Disposal in landfills has been the most common means of handling ash in circulating fluidized bed (CFB) boiler power plants. Recently, larger CFB boilers with generating capacities up to 300 MWe are currently being planned, resulting in increased volumes and disposal cost of ash by-product. Studies have shown that CFB ashes do not pose environmental concerns that should significantly limit their potential utilization. Many uses of CFB ash are being investigated by Foster Wheeler, which can provide more cost-effective ash management. Construction applications have been identified as one of the major uses for CFB ashes. Typically, CFB ash cannot be used as a cement replacement in concrete due to its unacceptably high sulfur content. However, CFB ashes can be used for other construction applications that require less stringent specifications including soil stabilization, road base, structural fill, and synthetic aggregate. In this study, potential construction applications were identified for fly ashes from several CFB boilers firing diverse fuels such as petroleum coke, refuse derived fuel (RDF) and coal. The compressive strength of hydrated fly ashes was measured in order to screen their potential for use in various construction applications. Based on the results of this work, the effects of both ash chemistry and carbon content on utilization potential were ascertained. Actual beneficial uses of ashes evaluated in this study are also discussed.

  15. Penrose Life: ash and oscillators Margaret Hill1

    E-Print Network [OSTI]

    Stepney, Susan

    Penrose Life: ash and oscillators Margaret Hill1 , Susan Stepney1 , and Francis Wan2 1 Department tiling grid. We in- vestigate the lifetime to stability, the final `ash' density, and the number quantitative behaviour, with shorter lifetimes, lower ash densities, and higher ocurrence of long

  16. A dying ash tree falls across your path.

    E-Print Network [OSTI]

    Pittendrigh, Barry

    Start here. 1 23 4 9 10 A dying ash tree falls and steals food and water from species that have always lived there. The Emerald Ash Borer (EAB) is a shiny on a bright copper . Emerald Ash Borers feed only on trees. You can find these trees in several settings

  17. IN HARM'S WAY: Lack Of Federal Coal Ash

    E-Print Network [OSTI]

    Short, Daniel

    IN HARM'S WAY: Lack Of Federal Coal Ash Regulations Endangers Americans And Their Environment 2010, Editor and Contributing Author #12;IN HARM'S WAY: Lack of Federal Coal Ash Regulations Endangers of Federal Coal Ash Regulations Endangers Americans and Their Environment Page iii Donna Lisenby and Eric

  18. Guide to Using Wood Ash as an Agricultural Soil Amendment

    E-Print Network [OSTI]

    New Hampshire, University of

    Guide to Using Wood Ash as an Agricultural Soil Amendment OLIVIA SAUNDERS, Extension Field Specialist "Wood ash contains significant amounts of potassium and calcium, while providing smaller amounts.unh.edu Spring 2014 UNH EXTENSION AGRICULTURE FACT SHEET Food & Agriculture Introduction Wood ash has a long

  19. Ash dieback disease www.forestry.gov.uk/planthealth

    E-Print Network [OSTI]

    Ash dieback disease www.forestry.gov.uk/planthealth Pest Alert Distribution In Britain, most of the outbreaks of ash dieback disease in the natural environment are confined to East Anglia and Kent, although a small number of outlying cases have been confirmed in northeast England and Scotland. Common ash

  20. Maintaining and Improving Marketability of Coal Fly Ash

    E-Print Network [OSTI]

    1 Maintaining and Improving Marketability of Coal Fly Ash John N. Ward Ben Franklin Headwaters;2 A Headline You May Have Seen What is the future of coal fly ash utilization in a mercury controls world? What other business and regulatory trends may affect ash utilization? Plants' Cleanup May Create Side

  1. WILDLIFE RESPONSE TO STAND STRUCTURE OF GREEN ASH WOODLANDS

    E-Print Network [OSTI]

    WILDLIFE RESPONSE TO STAND STRUCTURE OF GREEN ASH WOODLANDS by Robert A. Hodorff A thesis submitted Sciences, South Dakota State University. 1985 #12;WILDLIFE RESPONSE TO STAND STRUCTURE OF GREEN ASH, Department of Wildlife and Fisheries Sciences Date #12;WILDLIFE RESPONSE TO STAND STRUCTURE OF GREEN ASH

  2. Emerald Ash BY: DAVE CLOSE, ERIC WISEMAN AND SARAH GUGERCIN

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    Emerald Ash Borer BY: DAVE CLOSE, ERIC WISEMAN AND SARAH GUGERCIN VIRGINIA TECH PUBLICATION HORT-69NP #12;Emerald Ash Borer by Eric Wiseman, Sarah Gugercin, and Dave Close © 2013 Virginia Tech the Emerald Ash Borer Online Training Modules (2010), by Eric Wiseman, Sarah Gugercin, and Dave Close

  3. Detection and Classification of Ash Dieback on Large-Scale

    E-Print Network [OSTI]

    Detection and Classification of Ash Dieback on Large-Scale Color Aerial Photographs Ralph J of Agriculture 1966 #12;Croxton, Ralph J. 1966. Detection and classification of ash dieback on large- scale. Forest Serv. Res. Paper PSW-35) Aerial color photographs were taken at two scales over ash stands in New

  4. Screening technology reduces ash in spiral circuits

    SciTech Connect (OSTI)

    Brodzik, P. [Derrick Corp., Buffalo, NY (United States)

    2007-05-15

    In 2006, the James River Coal Co. selected the Stack Sizer to remove the minus 100 mesh high ash clay fraction from the clean coal spiral product circuits at the McCoy-Elkhorn Bevins Branch prep plant and at the Blue Diamond Leatherwood prep plant in Kentucky. The Stack Sizer is a multi-deck, high-frequency vibrating screen capable of separations as fine as 75 microns when fitted with Derrick Corp.'s patented high open area urethane screen panels. Full-scale lab tests and more than 10 months of continuous production have confirmed that the Stack Sizer fitted with Derrick 100 micron urethane screen panels consistently produces a clean coal fraction that ranges from 8 to 10% ash. Currently, each five-deck Stack Sizer operating at the Bevins Branch and Leatherwood prep plants is producing approximately 33 tons per hour of clean coal containing about 9% ash. This represents a clean coal yield of about 75% and an ash reduction of about 11% from the feed slurry. 3 figs. 2 tabs.

  5. Stabilizing soft fine-grained soils with fly ash

    SciTech Connect (OSTI)

    Edil, T.B.; Acosta, H.A.; Benson, C.H.

    2006-03-15

    The objective of this study was to evaluate the effectiveness of self-cementing fly ashes derived from combustion of subbituminous coal at electric power plants for stabilization of soft fine-grained soils. California bearing ratio (CBR) and resilient modulus (M{sub r}) tests were conducted on mixtures prepared with seven soft fine-grained soils (six inorganic soils and one organic soil) and four fly ashes. The soils were selected to represent a relatively broad range of plasticity, with plasticity indices ranging between 15 and 38. Two of the fly ashes are high quality Class C ashes (per ASTM C 618) that are normally used in Portland cement concrete. The other ashes are off-specification ashes, meaning they do not meet the Class C or Class F criteria in ASTM C 618. Tests were conducted on soils and soil-fly ash mixtures prepared at optimum water content (a standardized condition), 7% wet of optimum water content (representative of the typical in situ condition in Wisconsin), and 9-18% wet of optimum water content (representative of a very wet in situ condition). Addition of fly ash resulted in appreciable increases in the CBR and M{sub r} of the inorganic soils. For water contents 7% wet of optimum, CBRs of the soils alone ranged between 1 and 5. Addition of 10% fly ash resulted in CBRs ranging between 8 and 17, and 18% fly ash resulted in CBRs between 15 and 31. Similarly, M{sub r} of the soil alone ranged between 3 and 15 MPa at 7% wet of optimum, whereas addition of 10% fly ash resulted in M{sub r} between 12 and 60 MPa and 18% fly ash resulted in M{sub r} between 51 and 106 MPa. In contrast, except for one fly ash, addition of fly ash generally had little effect on CBR or M{sub r} of the organic soil.

  6. Fly ash and concrete: a study determines whether biomass, or coal co-firing fly ash, can be used in concrete

    SciTech Connect (OSTI)

    Wang, Shuangzhen; Baxter, Larry

    2006-08-01

    Current US national standards for using fly ash in concrete (ASTM C618) state that fly ash must come from coal combustion, thus precluding biomass-coal co-firing fly ash. The co-fired ash comes from a large and increasing fraction of US power plants due to rapid increases in co-firing opportunity fuels with coal. The fly ashes include coal fly ash, wood fly ash from pure wood combustion, biomass and coal co-fired fly ash SW1 and SW2. Also wood fly ash is blended with Class C or Class F to produce Wood C and Wood E. Concrete samples were prepared with fly ash replacing cement by 25%. All fly ash mixes except wood have a lower water demand than the pure cement mix. Fly ashes, either from coal or non coal combustion, increase the required air entraining agent (AEA) to meet the design specification of the mixes. If AEA is added arbitrarily without considering the amount or existence of fly ash results could lead to air content in concrete that is either too low or too high. Biomass fly ash does not impact concrete setting behaviour disproportionately. Switch grass-coal co-fired fly ash and blended wood fly ash generally lie within the range of pure coal fly ash strength. The 56 day flexure strength of all the fly ash mixes is comparable to that of the pure cement mix. The flexure strength from the coal-biomass co-fired fly ash does not differ much from pure coal fly ash. All fly ash concrete mixes exhibit lower chloride permeability than the pure cement mixes. In conclusion biomass coal co-fired fly ash perform similarly to coal fly ash in fresh and hardened concrete. As a result, there is no reason to exclude biomass-coal co-fired fly ash in concrete.

  7. Manufacture of ceramic tiles from fly ash

    DOE Patents [OSTI]

    Hnat, J.G.; Mathur, A.; Simpson, J.C.

    1999-08-10

    The present invention relates to a process for forming glass-ceramic tiles. Fly ash containing organic material, metal contaminants, and glass forming materials is oxidized under conditions effective to combust the organic material and partially oxidize the metallic contaminants and the glass forming materials. The oxidized glass forming materials are vitrified to form a glass melt. This glass melt is then formed into tiles containing metallic contaminants. 6 figs.

  8. Manufacture of ceramic tiles from fly ash

    DOE Patents [OSTI]

    Hnat, James G. (Collegeville, PA); Mathur, Akshay (Tampa, FL); Simpson, James C. (Perkiomenville, PA)

    1999-01-01

    The present invention relates to a process for forming glass-ceramic tiles. Fly ash containing organic material, metal contaminants, and glass forming materials is oxidized under conditions effective to combust the organic material and partially oxidize the metallic contaminants and the glass forming materials. The oxidized glass forming materials are vitrified to form a glass melt. This glass melt is then formed into tiles containing metallic contaminants.

  9. Application of solid ash based catalysts in heterogeneous catalysis

    SciTech Connect (OSTI)

    Shaobin Wang

    2008-10-01

    Solid wastes, fly ash, and bottom ash are generated from coal and biomass combustion. Fly ash is mainly composed of various metal oxides and possesses higher thermal stability. Utilization of fly ash for other industrial applications provides a cost-effective and environmentally friendly way of recycling this solid waste, significantly reducing its environmental effects. On the one hand, due to the higher stability of its major component, aluminosilicates, fly ash could be employed as catalyst support by impregnation of other active components for various reactions. On the other hand, other chemical compounds in fly ash such as Fe{sub 2}O{sub 3} could also provide an active component making fly ash a catalyst for some reactions. In this paper, physicochemical properties of fly ash and its applications for heterogeneous catalysis as a catalyst support or catalyst in a variety of catalytic reactions were reviewed. Fly-ash-supported catalysts have shown good catalytic activities for H{sub 2} production, deSOx, deNOx, hydrocarbon oxidation, and hydrocracking, which are comparable to commercially used catalysts. As a catalyst itself, fly ash can also be effective for gas-phase oxidation of volatile organic compounds, aqueous-phase oxidation of organics, solid plastic pyrolysis, and solvent-free organic synthesis. 107 refs., 4 figs., 2 tabs.

  10. The leaching characteristics of selenium from coal fly ashes

    SciTech Connect (OSTI)

    Wang, T.; Wang, J.; Burken, J.G.; Ban, H.; Ladwig, K.

    2007-11-15

    The leaching characteristics of selenium from several bituminous and subbituminous coal fly ashes under different pH conditions were investigated using batch methods. Results indicated that pH had a significant effect on selenium leaching from bituminous coal ash. The minimum selenium leaching occurred in the pH range between 3 and 4, while the maximum selenium leaching occurred at pH 12. The release of selenium from subbituminous coal ashes was very low for the entire experimental pH range, possibly due to the high content of calcium which can form hydration or precipitation products as a sink for selenium. The adsorption results for different selenium species indicated that Se(VI) was hardly adsorbable on either bituminous coal ashes or subbitumminous coal ashes at any pH. However, Se(I) was highly adsorbed by bituminous coal ashes under acidic pH conditions and was mostly removed by subbitumminous coal ashes across the entire pH range. This result suggests that the majority of selenium released from the tested fly ashes was Se(IV). A speciation-based model was developed to simulate the adsorption of Se(IV) on bituminous coal fly ash, and the pH-independent adsorption constants of HSeO{sup 3-} and SeO{sub 3}{sup 2-} were determined. The modeling approach is useful for understanding and predicting the release process of selenium from fly ash.

  11. Utilization of ash from municipal solid waste combustion

    SciTech Connect (OSTI)

    Jones, C.; Hahn, J.; Magee, B.; Yuen, N.; Sandefur, K.; Tom, J.; Yap, C.

    1999-09-01

    This ash study investigated the beneficial use of municipal waste combustion combined ash from the H-POWER facility in Oahu. These uses were grouped into intermediate cover for final closure of the Waipahu landfill, daily cover at the Waimanalo Gulch Landfill, and partial replacement for aggregate in asphalt for road paving. All proposed uses examine combined fly and bottom ash from a modern waste-to-energy facility that meets requirements of the Clean Air Act Amendments for Maximum Achievable Control Technology.

  12. Recovery of aluminum and other metal values from fly ash

    DOE Patents [OSTI]

    McDowell, William J. (Oak Ridge, TN); Seeley, Forest G. (Oak Ridge, TN)

    1981-01-01

    The invention described herein relates to a method for improving the acid leachability of aluminum and other metal values found in fly ash which comprises sintering the fly ash, prior to acid leaching, with a calcium sulfate-containing composition at a temperature at which the calcium sulfate is retained in said composition during sintering and for a time sufficient to quantitatively convert the aluminum in said fly ash into an acid-leachable form.

  13. Coal Ash Behavior in Reducing Environments (CABRE) III Year 6...

    Office of Scientific and Technical Information (OSTI)

    (CABRE) III Year 6 - Activity 1.10 - Development of a National Center for Hydrogen Citation Details In-Document Search Title: Coal Ash Behavior in Reducing Environments...

  14. Data Summary Report for Hanford Site Coal Ash Characterization

    SciTech Connect (OSTI)

    Sulloway, H. M.

    2012-03-06

    The purpose of this report is to present data and findings from sampling and analysis of five distinct areas of coal ash within the Hanford Site River Corridor

  15. Retention of elemental mercury in fly ashes in different atmospheres

    SciTech Connect (OSTI)

    M.A. Lopez-Anton; M. Diaz-Somoano; M.R. Martinez-Tarazona

    2007-01-15

    Mercury is an extremely volatile element, which is emitted from coal combustion to the environment mostly in the vapor phase. To avoid the environmental problems that the toxic species of this element may cause, control technologies for the removal of mercury are necessary. Recent research has shown that certain fly ash materials have an affinity for mercury. Moreover, it has been observed that fly ashes may catalyze the oxidation of elemental mercury and facilitate its capture. However, the exact nature of Hg-fly ash interactions is still unknown, and mercury oxidation through fly ash needs to be investigated more thoroughly. In this work, the influence of a gas atmosphere on the retention of elemental mercury on fly ashes of different characteristics was evaluated. The retention capacity was estimated comparatively in inert and two gas atmospheres containing species present in coal gasification and coal combustion. Fly ashes produced in two pulverized coal combustion (PCC) plants, produced from coals of different rank (CTA and CTSR), and a fly ash (CTP) produced in a fluidized bed combustion (FBC) plant were used as raw materials. The mercury retention capacity of these fly ashes was compared to the retention obtained in different activated carbons. Although the capture of mercury is very similar in the gasification atmosphere and N{sub 2}, it is much more efficient in a coal combustion retention, being greater in fly ashes from PCC than those from FBC plants. 22 refs., 6 figs., 3 tabs.

  16. Using fly ash and natural pozzolans in long life structures

    SciTech Connect (OSTI)

    Ramme, B.; Jacobsmeyer, J.

    2008-07-01

    The use of fly ash and natural pozzolans in various structures (roads, temples, bridges, buildings etc.) in the USA and Canada is discussed. 22 refs., 4 photos.

  17. The effects of eccentric training on muscle-bone function 

    E-Print Network [OSTI]

    Hubal, Monica Jeanne

    1999-01-01

    implantation, while a sham ovariectomy group (SHAM) served as an estrogen-intact control. One-half of the ovariectomized mice (OVX) underwent training via 30 eccentric contractions of the anterior coral muscles at 150% of peak isometric torque (OVX+TRAIN) every...

  18. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    dose. The graphs show that there is a severe and progressive degradation in mechanical properties, specifically in the bending stressstrain properties, with increase in x-ray...

  19. Vitamin D and Systemic Lupus Erythematosus: Bones, Muscles, and Joints

    E-Print Network [OSTI]

    Lane, Nancy E.

    2010-01-01

    Cole DE, Gladman DD, et al. : Vitamin D insuffi- ciency in aJG, Kasamatsu T, et al. : Vitamin D deficiency in patientsBrown AJ: Mechanism of vitamin D action and its regulation.

  20. Colloquium: Failure of molecules, bones, and the Earth itself

    E-Print Network [OSTI]

    Buehler, Markus J.

    Materials fail by recurring rupture and shearing of interatomic bonds at microscopic, molecular scales, leading to disintegration of matter at macroscale and a loss of function. In this Colloquium, the state-of-the-art of ...

  1. Bone Is a Target for the Antidiabetic Compound Rosiglitazone

    E-Print Network [OSTI]

    Abraham, Nader G.

    and the inhibition of hepatic gluconeogenesis (3). In patients with type 2 diabetes, rosiglitazone reduces levels

  2. Consolidant particle transport in limestone, concrete and bone 

    E-Print Network [OSTI]

    Campbell, Alanna Stacey

    2013-11-28

    The use of chemically compatible nano and fine particle colloidal consolidants is a new development within the field of cultural heritage conservation and applied most widely so far to the historic built environment. The ...

  3. Studies of Bone Metabolism with the Aid of Radioactive Strontium

    E-Print Network [OSTI]

    Jones, D.C.

    2010-01-01

    National Laboratory Atomic Energy Commission, Washingtoneng-48A-l, with the Atomic Energy Commission in cO.IDlection

  4. Characterization of mineralized collagenglycosaminoglycan scaffolds for bone regeneration

    E-Print Network [OSTI]

    Van Vliet, Krystyn J.

    properties for the scaffolds; the discrepancy arises from defects such as disconnected pore walls within scaffolds can be made by negative mold infiltration, ceramic scaffolds can be made by a casting

  5. Hip Bone is Connected to..... Leo P. Kadanoff

    E-Print Network [OSTI]

    Kadanoff, Leo P.

    and thus given us a partial topology of some of the most important biological networks. Further in Drosophila at the termination of the developmental stage under study. The investigators studied some 200

  6. Bones, Skin and Spirit of a City [Portfolio

    E-Print Network [OSTI]

    Milford, Kate

    2004-01-01

    Kate Milford When the Brooklyn Bridge was ?nished in 1883Manhattan Bridge and Brooklyn Bridges spill their constant

  7. The effects of adult-onset alcoholism on cortical bone 

    E-Print Network [OSTI]

    Moe, Atha Louise

    2001-01-01

    -fed liquid control diet or rat pellet chow for either 8 or 14 weeks. An additional group of animals (alcohol cessation and pair-fed cessation) was fed the alcohol diet for 8 weeks with pair-fed partners receiving the liquid control diet. These animals were...

  8. Structural and biological studies of bone morphogenetic protein-15

    E-Print Network [OSTI]

    McMahon, Heather Eileen

    2007-01-01

    treatment options for infertile couples, but continued research into the underlying causes of infertility

  9. Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Synchrotron

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News Publications TraditionalWithAntiferromagnetic Spins DoApplyArchaeological

  10. Research Finds Vitamin D Deficiency Affects Bone Quality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMassR&D100 WinnersAffiliates Research Affiliates Yan Mei Wang Yan Mei and

  11. Research Finds Vitamin D Deficiency Affects Bone Quality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMassR&D100 WinnersAffiliates Research Affiliates Yan Mei Wang Yan Mei andResearch Finds

  12. Research Finds Vitamin D Deficiency Affects Bone Quality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMassR&D100 WinnersAffiliates Research Affiliates Yan Mei Wang Yan Mei andResearch

  13. Research Finds Vitamin D Deficiency Affects Bone Quality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMassR&D100 WinnersAffiliates Research Affiliates Yan Mei Wang Yan Mei

  14. Research Finds Vitamin D Deficiency Affects Bone Quality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMassR&D100 WinnersAffiliates Research Affiliates Yan Mei Wang Yan MeiResearch Finds

  15. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATIONIntroducing theActivation by Cytochrome P450 |

  16. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATIONIntroducing theActivation by Cytochrome P450 |Irradiation

  17. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATIONIntroducing theActivation by Cytochrome P450

  18. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATIONIntroducing theActivation by Cytochrome P450Irradiation

  19. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATIONIntroducing theActivation by Cytochrome

  20. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenryInhibitingInteractivePGAS andUniversity IonIron is the Key

  1. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenryInhibitingInteractivePGAS andUniversity IonIron is the

  2. Research Finds Vitamin D Deficiency Affects Bone Quality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) by Carbon-RichProtonAboutNuclearPrincipalResearch

  3. Research Finds Vitamin D Deficiency Affects Bone Quality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) by Carbon-RichProtonAboutNuclearPrincipalResearchResearch Finds Vitamin D

  4. Prehistoric Animal Bones Found at Pantex | National Nuclear Security

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesseworkSURVEYI/OPerformancePi Day PiSafetyContactAboutRobots and

  5. Celebrating Black History Month with DOE's Sheri Bone | Department of

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirley Ann JacksonDepartment|Marketing, LLCEfficiencyCOP 21: The06(201)Energy TravisEnergy

  6. Arsenic remediation of drinking water using iron-oxide coated coal bottom ash

    E-Print Network [OSTI]

    MATHIEU, JOHANNA L.

    2010-01-01

    using Iron-oxide Coated Coal Ash. In Arsenic Contaminationwater using  iron?oxide coated coal bottom ash  Johanna L.  using iron-oxide coated coal bottom ash JOHANNA L. MATHIEU

  7. Utilization of Ash Fractions from Alternative Biofuels used in Power Plants

    E-Print Network [OSTI]

    Utilization of Ash Fractions from Alternative Biofuels used in Power Plants PSO Project No. 6356 July 2008 Renewable Energy and Transport #12;2 Utilization of Ash Fractions from Alternative Biofuels)...............................................................................7 2. Production of Ash Products from Mixed Biofuels

  8. Dechlorination ability of municipal waste incineration fly ash for polychlorinated phenols

    E-Print Network [OSTI]

    Cirkva, Vladimir

    Dechlorination ability of municipal waste incineration fly ash for polychlorinated phenols Leona incineration fly ash at 200 °C under nitrogen atmosphere. Thermodynamic calculations have been carried out synthesis; Fly ash; Dechlorination; PCDD; Thermodynamics 1. Introduction Previous works of other authors

  9. Arsenic remediation of drinking water using iron-oxide coated coal bottom ash

    E-Print Network [OSTI]

    MATHIEU, JOHANNA L.

    2010-01-01

    using Iron-oxide Coated Coal Ash. In Arsenic Contaminationfrom aqueous solutions by fly ash. Water Res. 1993, 27(12),of Cations in Class F Fly Ash. Environ. Sci. Technol. 2003,

  10. ON FOUR-DIMENSIONAL MOD 2 GALOIS REPRESENTATIONS AND A CONJECTURE OF ASH

    E-Print Network [OSTI]

    Moon, Hyunsuk

    ON FOUR-DIMENSIONAL MOD 2 GALOIS REPRESENTATIONS AND A CONJECTURE OF ASH ET AL. HYUNSUK MOON of is totally real. The Theorem settles a special case of a conjecture of Ash-Sinnott ([2]) and of Ash

  11. Seasonal effects of volatile oils in ashe and redberry juniper on preference and digestibility by goats 

    E-Print Network [OSTI]

    Riddle, Richard R.

    1994-01-01

    (qnodon dactylon (L.) Pers.), ashe juniper (Juniperus ashei Buchholz) and live Oak [Quercus virginiana (Small) Sarg. var. fusiformis] during the spring and fall. Angora and Spanish goats were exposed to ashe female, ashe male, redberry female and redberry...

  12. THE ROLE OF FLY ASH IN CATALYTIC OXIDATION OF S(IV) SLURRIES

    E-Print Network [OSTI]

    Cohen, Sidney

    2014-01-01

    and Technology THE ROLE OF FLY ASH IN CATALYTIC OXIDATION OFof California. THE ROLE OF FLY ASH IN CATALYTIC OXIDATION OFg los~ S(IV) in aqueous fly ash slurries :n;- and 0 , and SO

  13. Process for the recovery of alumina from fly ash

    DOE Patents [OSTI]

    Murtha, M.J.

    1983-08-09

    An improvement in the lime-sinter process for recovering alumina from pulverized coal fly ash is disclosed. The addition of from 2 to 10 weight percent carbon and sulfur to the fly ash-calcium carbonate mixture increase alumina recovery at lower sintering temperatures.

  14. The recycling of the coal fly ash in glass production

    SciTech Connect (OSTI)

    Erol, M.M.; Kucukbayrak, S.; Ersoy-Mericboyu, A.

    2006-09-15

    The recycling of fly ash obtained from the combustion of coal in thermal power plant has been studied. Coal fly ash was vitrified by melting at 1773 K for 5 hours without any additives. The properties of glasses produced from coal fly ash were investigated by means of Differential Thermal Analysis (DTA), X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) techniques. DTA study indicated that there was only one endothermic peak at 1003 K corresponding to the glass transition temperature. XRD analysis showed the amorphous state of the glass sample produced from coal fly ash. SEM investigations revealed that the coal fly ash based glass sample had smooth surface. The mechanical, physical and chemical properties of the glass sample were also determined. Recycling of coal fly ash by using vitrification technique resulted to a glass material that had good mechanical, physical and chemical properties. Toxicity characteristic leaching procedure (TCLP) results showed that the heavy metals of Pb, Cr, Zn and Mn were successfully immobilized into the glass. It can be said that glass sample obtained by the recycling of coal fly ash can be taken as a non-hazardous material. Overall, results indicated that the vitrification technique is an effective way for the stabilization and recycling of coal fly ash.

  15. Optimizing the use of fly ash in concrete

    SciTech Connect (OSTI)

    Thomas, M.

    2007-07-01

    The optimum amount of fly ash varies not only with the application, but also with composition and proportions of all the materials in the concrete mixture (especially the fly ash), the conditions during placing (especially temperature), construction practices (for example, finishing and curing) and the exposure conditions. This document discusses issues related to using low to very high levels of fly ash in concrete and provides guidance for the use of fly ash without compromising the construction process or the quality of the finished product. The nature of fly ashes including their physical, mineralogical and chemical properties is covered in detail, as well as fly ash variability due to coal composition and plant operating conditions. A discussion on the effects of fly ash characteristics on fresh and hardened concrete properties includes; workability, bleeding, air entrainment, setting time, heat of hydration, compressive strength development, creep, drying shrinkage, abrasion resistance, permeability, resistance to chlorides, alkali-silica reaction (ASR), sulfate resistance, carbonation, and resistance to freezing and thawing and deicer salt scaling. Case studies were selected as examples of some of the more demanding applications of fly ash concrete for ASR mitigation, chloride resistance, and green building.

  16. Uncovering Fundamental Ash-Formation Mechanisms and Potential Means to Control the Impact on DPF Performance and Engine Efficiency

    Broader source: Energy.gov [DOE]

    Results illustrate ash particle growth and formation pathways, and influence of lubricant chemistry and exhaust conditions on fundamental ash properties

  17. Optical properties of fly ash. Volume 1, Final report

    SciTech Connect (OSTI)

    Self, S.A.

    1994-12-01

    Research performed under this contract was divided into four tasks under the following headings: Task 1, Characterization of fly ash; Task 2, Measurements of the optical constants of slags; Task 3, Calculations of the radiant properties of fly ash dispersions; and Task 4, Measurements of the radiant properties of fly ash dispersions. Tasks 1 and 4 constituted the Ph.D. research topic of Sarbajit Ghosal, while Tasks 2 and 3 constituted the Ph.D. research topic of Jon Ebert. Together their doctoral dissertations give a complete account of the work performed. This final report, issued in two volumes consists of an executive summary of the whole program followed by the dissertation of Ghosal. Volume 1 contains the dissertation of Ghosal which covers the characterization of fly ash and the measurements of the radiant properties of fly ash dispersions. A list of publications and conference presentations resulting from the work is also included.

  18. Toxicity mitigation and solidification of municipal solid waste incinerator fly ash using alkaline activated coal ash

    SciTech Connect (OSTI)

    Ivan Diaz-Loya, E.; Allouche, Erez N.; Eklund, Sven; Joshi, Anupam R.; Kupwade-Patil, Kunal

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer Incinerator fly ash (IFA) is added to an alkali activated coal fly ash (CFA) matrix. Black-Right-Pointing-Pointer Means of stabilizing the incinerator ash for use in construction applications. Black-Right-Pointing-Pointer Concrete made from IFA, CFA and IFA-CFA mixes was chemically characterized. Black-Right-Pointing-Pointer Environmentally friendly solution to IFA disposal by reducing its toxicity levels. - Abstract: Municipal solid waste (MSW) incineration is a common and effective practice to reduce the volume of solid waste in urban areas. However, the byproduct of this process is a fly ash (IFA), which contains large quantities of toxic contaminants. The purpose of this research study was to analyze the chemical, physical and mechanical behaviors resulting from the gradual introduction of IFA to an alkaline activated coal fly ash (CFA) matrix, as a mean of stabilizing the incinerator ash for use in industrial construction applications, where human exposure potential is limited. IFA and CFA were analyzed via X-ray fluorescence (XRF), X-ray diffraction (XRD) and Inductive coupled plasma (ICP) to obtain a full chemical analysis of the samples, its crystallographic characteristics and a detailed count of the eight heavy metals contemplated in US Title 40 of the Code of Federal Regulations (40 CFR). The particle size distribution of IFA and CFA was also recorded. EPA's Toxicity Characteristic Leaching Procedure (TCLP) was followed to monitor the leachability of the contaminants before and after the activation. Also images obtained via Scanning Electron Microscopy (SEM), before and after the activation, are presented. Concrete made from IFA, CFA and IFA-CFA mixes was subjected to a full mechanical characterization; tests include compressive strength, flexural strength, elastic modulus, Poisson's ratio and setting time. The leachable heavy metal contents (except for Se) were below the maximum allowable limits and in many cases even below the reporting limit. The leachable Chromium was reduced from 0.153 down to 0.0045 mg/L, Arsenic from 0.256 down to 0.132 mg/L, Selenium from 1.05 down to 0.29 mg/L, Silver from 0.011 down to .001 mg/L, Barium from 2.06 down to 0.314 mg/L and Mercury from 0.007 down to 0.001 mg/L. Although the leachable Cd exhibited an increase from 0.49 up to 0.805 mg/L and Pd from 0.002 up to 0.029 mg/L, these were well below the maximum limits of 1.00 and 5.00 mg/L, respectively.

  19. COAL-FIRED UTILITY BOILERS: SOLVING ASH DEPOSITION PROBLEMS

    SciTech Connect (OSTI)

    Christopher J. Zygarlicke; Donald P. McCollor; Steven A. Benson; Jay R. Gunderson

    2001-04-01

    The accumulation of slagging and fouling ash deposits in utility boilers has been a source of aggravation for coal-fired boiler operators for over a century. Many new developments in analytical, modeling, and combustion testing methods in the past 20 years have made it possible to identify root causes of ash deposition. A concise and comprehensive guidelines document has been assembled for solving ash deposition as related to coal-fired utility boilers. While this report accurately captures the current state of knowledge in ash deposition, note that substantial research and development is under way to more completely understand and mitigate slagging and fouling. Thus, while comprehensive, this document carries the title ''interim,'' with the idea that future work will provide additional insight. Primary target audiences include utility operators and engineers who face plant inefficiencies and significant operational and maintenance costs that are associated with ash deposition problems. Pulverized and cyclone-fired coal boilers are addressed specifically, although many of the diagnostics and solutions apply to other boiler types. Logic diagrams, ash deposit types, and boiler symptoms of ash deposition are used to aid the user in identifying an ash deposition problem, diagnosing and verifying root causes, determining remedial measures to alleviate or eliminate the problem, and then monitoring the situation to verify that the problem has been solved. In addition to a step-by-step method for identifying and remediating ash deposition problems, this guideline document (Appendix A) provides descriptions of analytical techniques for diagnostic testing and gives extensive fundamental and practical literature references and addresses of organizations that can provide help in alleviating ash deposition problems.

  20. Effect of fuel properties on the bottom ash generation rate by a laboratory fluidized bed combustor

    SciTech Connect (OSTI)

    Rozelle, P.L.; Pisupati, S.V.; Scaroni, A.W.

    2007-06-15

    The range of fuels that can be accommodated by an FBC boiler system is affected by the ability of the fuel, sorbent, and ash-handling equipment to move the required solids through the boiler. Of specific interest is the bottom ash handling equipment, which must have sufficient capacity to remove ash from the system in order to maintain a constant bed inventory level, and must have sufficient capability to cool the ash well below the bed temperature. Quantification of a fuel's bottom ash removal requirements can be useful for plant design. The effect of fuel properties on the rate of bottom ash production in a laboratory FBC test system was examined. The work used coal products ranging in ash content from 20 to 40+ wt. %. The system's classification of solids by particle size into flyash and bottom ash was characterized using a partition curve. Fuel fractions in the size range characteristic of bottom ash were further analyzed for distributions of ash content with respect to specific gravity, using float sink tests. The fuel fractions were then ashed in a fixed bed. In each case, the highest ash content fraction produced ash with the coarsest size consist (characteristic of bottom ash). The lower ash content fractions were found to produce ash in the size range characteristic of flyash, suggesting that the high ash content fractions were largely responsible for the production of bottom ash. The contributions of the specific gravity fractions to the composite ash in the fuels were quantified. The fuels were fired in the laboratory test system. Fuels with higher amounts of high specific gravity particles, in the size ranges characteristic of bottom ash, were found to produce more bottom ash, indicating the potential utility of float sink methods in the prediction of bottom ash removal requirements.

  1. Mutagenicity and genotoxicity of coal fly ash water leachate

    SciTech Connect (OSTI)

    Chakraborty, R.; Mukherjee, A.

    2009-03-15

    Fly ash is a by-product of coal-fired electricity generation plants. The prevalent practice of disposal is as slurry of ash and water to storage or ash ponds located near power stations. This has lain to waste thousands of hectares of land all over the world. Since leaching is often the cause of off-site contamination and pathway of introduction into the human environment, a study on the genotoxic effects of fly ash leachate is essential. Leachate prepared from the fly ash sample was analyzed for metal content, and tested for mutagenicity and genotoxicity. Analyses of metals show predominance of the metals - sodium, silicon, potassium, calcium, magnesium, iron, manganese, zinc, and sulphate. The Ames Salmonella mutagenicity assay, a short-term bacterial reverse mutation assay, was conducted on two-tester strains of Salmonella typhimurium strains TA97a and TA102. For genotoxicity, the alkaline version of comet assay on fly ash leachate was carried in vitro on human blood cells and in vivo on Nicotiana plants. The leachate was directly mutagenic and induced significantconcentration-dependent increases in DNA damage in whole blood cells, lymphocytes, and in Nicotiana plants. The comet parameters show increases in tail DNA percentage (%), tail length (mu m), and olive tail moment (arbitrary units). Our results indicate that leachate from fly ash dumpsites has the genotoxic potential and may lead to adverse effects on vegetation and on the health of exposed human populations.

  2. Water holding capacities of fly ashes: Effect of size fractionation

    SciTech Connect (OSTI)

    Sarkar, A.; Rano, R.

    2007-07-01

    Water holding capacities of fly ashes from different thermal power plants in Eastern India have been compared. Moreover, the effect of size fractionation (sieving) on the water holding capacities has also been determined. The desorption rate of water held by the fly ash fractions at ambient temperature (25-30{sup o}C) has been investigated. The effect of mixing various size fractions of fly ash in increasing the water holding capacities of fly ash has been studied. It is observed that the fly ash obtained from a thermal power plant working on stoker-fired combustor has the highest water holding capacity, followed by the one that works on pulverized fuel combustor. Fly ash collected from super thermal power plant has the least water holding capacity (40.7%). The coarser size fractions of fly ashes in general have higher water holding capacities than the finer ones. An attempt has been made to correlate the results obtained, with the potential use in agriculture.

  3. Distribution of arsenic and mercury in lime spray dryer ash

    SciTech Connect (OSTI)

    Panuwat Taerakul; Ping Sun; Danold W. Golightly; Harold W. Walker; Linda K. Weavers

    2006-08-15

    The partitioning of As and Hg in various components of lime spray dryer (LSD) ash samples from a coal-fired boiler was characterized to better understand the form and fate of these elements in flue gas desulfurization byproducts. LSD ash samples, collected from the McCracken Power Plant on the Ohio State University campus, were separated by a 140-mesh (106 {mu}m) sieve into two fractions: a fly-ash-/unburned-carbon-enriched fraction (> 106 {mu}m) and a calcium-enriched fraction (< 106 {mu}m). Unburned carbon and fly ash in the material > 106 {mu}m were subsequently separated by density using a lithium heteropolytungstate solution. The concentrations of As and Hg were significant in all fractions. The level of As was consistently greater in the calcium-enriched fraction, while Hg was evenly distributed in all components of LSD ash. Specific surface area was an important factor controlling the distribution of Hg in the different components of LSD ash, but not for As. Comparing the LSD ash data to samples collected from the economizer suggests that As was effectively captured by fly ash at 600{sup o}C, while Hg was not. Leaching tests demonstrated that As and Hg were more stable in the calcium-enriched fraction than in the fly-ash- or carbon-enriched fractions, potentially because of the greater pH of the leachate and subsequently greater stability of small amounts of calcium solids containing trace elements in these fractions. 37 refs., 8 figs., 2 tabs.

  4. Recovery of iron oxide from coal fly ash

    DOE Patents [OSTI]

    Dobbins, Michael S. (Ames, IA); Murtha, Marlyn J. (Ames, IA)

    1983-05-31

    A high quality iron oxide concentrate, suitable as a feed for blast and electric reduction furnaces is recovered from pulverized coal fly ash. The magnetic portion of the fly ash is separated and treated with a hot strong alkali solution which dissolves most of the silica and alumina in the fly ash, leaving a solid residue and forming a precipitate which is an acid soluble salt of aluminosilicate hydrate. The residue and precipitate are then treated with a strong mineral acid to dissolve the precipitate leaving a solid residue containing at least 90 weight percent iron oxide.

  5. Increasing Class C fly ash reduces alkali silica reactivity

    SciTech Connect (OSTI)

    Hicks, J.K.

    2007-07-01

    Contrary to earlier studies, it has been found that incremental additions of Class C fly ash do reduce alkali silica reactivity (ASR), in highly reactive, high alkali concrete mixes. AST can be further reduced by substituting 5% metakaolin or silica fume for the aggregate in concrete mixes with high (more than 30%) Class C fly ash substitution. The paper reports results of studies using Class C fly ash from the Labadie Station plant in Missouri which typically has between 1.3 and 1.45% available alkalis by ASTM C311. 7 figs.

  6. Helium Ash Simulation Studies with Divertor Helium Pumping in JET Internal Transport Barrier Discharges

    E-Print Network [OSTI]

    Helium Ash Simulation Studies with Divertor Helium Pumping in JET Internal Transport Barrier Discharges

  7. Respiratory and Reproductive Characteristics of Eastern Mosquitofish (Gambusia holbrooki) Inhabiting a Coal Ash Settling Basin

    E-Print Network [OSTI]

    Hopkins, William A.

    ) Inhabiting a Coal Ash Settling Basin B. P. Staub, W. A. Hopkins, J. Novak, J. D. Congdon Savannah River 2002/Accepted: 29 March 2002 Abstract. Coal fly ash and effluent from coal ash settling basins viable populations in areas contaminated by coal ash. While eastern mosquitofish are present

  8. Color Removal from Pulp Mill Effluent Using Coal Ash Produced from Georgia Coal Combustion Power Plants

    E-Print Network [OSTI]

    Hutcheon, James M.

    Color Removal from Pulp Mill Effluent Using Coal Ash Produced from Georgia Coal Combustion Power color from pulp mill effluent using coal ash. Prevent coal ash adsorbent from leaching arsenic, chromium, lead, and zinc. Define a treatment procedure using coal ash that will result in the maximum

  9. Book Review C. J. Ash and J. Knight. Computable Structures and the

    E-Print Network [OSTI]

    Harizanov, Valentina S.

    Book Review C. J. Ash and J. Knight. Computable Structures and the Hyperarithmetical Hierarchy E-mail: harizanv@gwu.edu Chris Ash started Computable Structures and the Hyperarithmetical Hi-95. Tragically, Chris Ash's life came to a sudden end in 1995. Julia Knight, working from Ash's outline

  10. In situ production of ash in pyroclastic flows J. Dufek1,2

    E-Print Network [OSTI]

    Manga, Michael

    In situ production of ash in pyroclastic flows J. Dufek1,2 and M. Manga1 Received 17 December 2007 for the enhanced production of volcanic ash, however, their relative importance has eluded quantification. The amount of ash produced in situ can potentially affect runout distance, deposit sorting, the volume of ash

  11. AO17: Ash detection and characterisation in IASI data Candidate number: 441639

    E-Print Network [OSTI]

    Oxford, University of

    AO17: Ash detection and characterisation in IASI data Candidate number: 441639 Supervisors: Dr E. Carboni and Dr R. G. Grainger Word count: 4275 Abstract Methods for the fast detection of volcanic ash aircraft of the presence of volcanic ash. Previous methods for detecting ash can gener- ate many false

  12. Eos, Vol. 79, No. 42, October 20, 1998 Volcanic Ash Can Pose

    E-Print Network [OSTI]

    Becker, Thorsten W.

    Eos, Vol. 79, No. 42, October 20, 1998 Volcanic Ash Can Pose Hazards to Air Traffic PAGES 505 and potentially deadly problems that can arise from volcanic ash clouds. The clouds can rise into the cruise the ash. The ash can ruin planes, and cause loss of thrust and even flameouts. It also can slicken runways

  13. A trial site planted with ash saplings. During the past year, Forest Research has continued to

    E-Print Network [OSTI]

    A trial site planted with ash saplings. Our Research During the past year, Forest Research has the range of our current research. Ash dieback: finding resistant trees Ash dieback (Chalara fraxinea) is affecting ash trees in Britain, especially East Anglia and Kent. This is a very serious disease of one

  14. Sound-induced ash illusion as an optimal percept Ladan Shamsa,b

    E-Print Network [OSTI]

    Shams, Ladan B.

    Sound-induced £ash illusion as an optimal percept Ladan Shamsa,b , Wei Ji Mab and Ulrik Beierholmc. For example, when a single £ash is accompanied by multiple auditory beeps, it is often per- ceived as multiple £ashes. This e¡ect is known as the sound- induced £ash illusion. In order to investigate the principles

  15. Sound-induced illusory ash perception: role of gamma band responses

    E-Print Network [OSTI]

    Shams, Ladan B.

    Sound-induced illusory £ash perception: role of gamma band responses Joydeep Bhattacharya,1,2,CA; accepted 9 July 2002 In the recently discovered sound-induced illusory £ash phenomen- on, a single £ash substrates distinguishing illusion and no-illusion (i.e. perception of single £ash) percepts are under

  16. Emerald Ash Borer Trapping Procedures 2013 Texas A&M Forest Service

    E-Print Network [OSTI]

    1 Emerald Ash Borer Trapping Procedures 2013 Texas A&M Forest Service Goal: To survey ash habitats in selected counties in Texas to detect the presence of the emerald ash borer, EAB (Agrilus of a circular 250-acre (1/2 square mile) sampling area. The trap is to be hung from the lower branch of an ash

  17. The Development of a Small Engine Based Ash Loading Protocol

    Broader source: Energy.gov [DOE]

    When 5% lubrication oil is added to diesel fuel in a small engine test, ash increases linearly and at the back of a filter, the amount depending on the differences in substrate and wash-coat type.

  18. Compressive strength of concrete and mortar containing fly ash

    DOE Patents [OSTI]

    Liskowitz, J.W.; Wecharatana, M.; Jaturapitakkul, C.; Cerkanowicz, A.E.

    1998-12-29

    The present invention relates to concrete, mortar and other hardenable mixtures comprising cement and fly ash for use in construction. The invention includes a method for predicting the compressive strength of such a hardenable mixture, which is very important for planning a project. The invention also relates to hardenable mixtures comprising cement and fly ash which can achieve greater compressive strength than hardenable mixtures containing only concrete over the time period relevant for construction. In a specific embodiment, a formula is provided that accurately predicts compressive strength of concrete containing fly ash out to 180 days. In other specific examples, concrete and mortar containing about 15% to 25% fly ash as a replacement for cement, which are capable of meeting design specification required for building and highway construction, are provided. Such materials can thus significantly reduce construction costs. 33 figs.

  19. Compressive strength of concrete and mortar containing fly ash

    DOE Patents [OSTI]

    Liskowitz, John W. (Belle Mead, NJ); Wecharatana, Methi (Parsippany, NJ); Jaturapitakkul, Chai (Bangkok, TH); Cerkanowicz, deceased, Anthony E. (late of Livingston, NJ)

    1997-01-01

    The present invention relates to concrete, mortar and other hardenable mixtures comprising cement and fly ash for use in construction. The invention includes a method for predicting the compressive strength of such a hardenable mixture, which is very important for planning a project. The invention also relates to hardenable mixtures comprising cement and fly ash which can achieve greater compressive strength than hardenable mixtures containing only concrete over the time period relevant for construction. In a specific embodiment, a formula is provided that accurately predicts compressive strength of concrete containing fly ash out to 180 days. In other specific examples, concrete and mortar containing about 15% to 25% fly ash as a replacement for cement, which are capable of meeting design specifications required for building and highway construction, are provided. Such materials can thus significantly reduce construction costs.

  20. Compressive strength of concrete and mortar containing fly ash

    DOE Patents [OSTI]

    Liskowitz, John W. (Belle Mead, NJ); Wecharatana, Methi (Parsippany, NJ); Jaturapitakkul, Chai (Bangkok, TH); Cerkanowicz, deceased, Anthony E. (late of Livingston, NJ)

    1998-01-01

    The present invention relates to concrete, mortar and other hardenable mixtures comprising cement and fly ash for use in construction. The invention includes a method for predicting the compressive strength of such a hardenable mixture, which is very important for planning a project. The invention also relates to hardenable mixtures comprising cement and fly ash which can achieve greater compressive strength than hardenable mixtures containing only concrete over the time period relevant for construction. In a specific embodiment, a formula is provided that accurately predicts compressive strength of concrete containing fly ash out to 180 days. In other specific examples, concrete and mortar containing about 15% to 25% fly ash as a replacement for cement, which are capable of meeting design specification required for building and highway construction, are provided. Such materials can thus significantly reduce construction costs.

  1. Compressive strength of concrete and mortar containing fly ash

    DOE Patents [OSTI]

    Liskowitz, J.W.; Wecharatana, M.; Jaturapitakkul, C.; Cerkanowicz, A.E.

    1997-04-29

    The present invention relates to concrete, mortar and other hardenable mixtures comprising cement and fly ash for use in construction. The invention includes a method for predicting the compressive strength of such a hardenable mixture, which is very important for planning a project. The invention also relates to hardenable mixtures comprising cement and fly ash which can achieve greater compressive strength than hardenable mixtures containing only concrete over the time period relevant for construction. In a specific embodiment, a formula is provided that accurately predicts compressive strength of concrete containing fly ash out to 180 days. In other specific examples, concrete and mortar containing about 15% to 25% fly ash as a replacement for cement, which are capable of meeting design specifications required for building and highway construction, are provided. Such materials can thus significantly reduce construction costs. 33 figs.

  2. Recoverable immobilization of transuranic elements in sulfate ash

    DOE Patents [OSTI]

    Greenhalgh, Wilbur O. (Richland, WA)

    1985-01-01

    Disclosed is a method of reversibly immobilizing sulfate ash at least about 20% of which is sulfates of transuranic elements. The ash is mixed with a metal which can be aluminum, cerium, samarium, europium, or a mixture thereof, in amounts sufficient to form an alloy with the transuranic elements, plus an additional amount to reduce the transuranic element sulfates to elemental form. Also added to the ash is a fluxing agent in an amount sufficient to lower the percentage of the transuranic element sulfates to about 1% to about 10%. The mixture of the ash, metal, and fluxing agent is heated to a temperature sufficient to melt the fluxing agent and the metal. The mixture is then cooled and the alloy is separated from the remainder of the mixture.

  3. Transcending Portland Cement with 100 percent fly ash concrete

    SciTech Connect (OSTI)

    Cross, D.; Akin, M.; Stephens, J.; Cuelh, E.

    2009-07-01

    The use of concrete, made with 100% fly ash and no Portland cement, in buildings at the Transportation Institute in Bozeman, MT, USA, is described. 3 refs., 7 figs.

  4. Enhancement of phosphogypsum with high lime fly ash 

    E-Print Network [OSTI]

    Gregory, Chuck Alan

    1983-01-01

    ENHANCEMENT OF PHOSPHOGYPSUM WITH HIGH LIME FLY ASH A Thesis by CHUCK ALAN GREGORY Submitted to the Graduate College of Texas ASM University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE May 1983 Major... Subject: Civil Engineering ENHANCEMENT OF PHOSPHOGYPSUM WITH HIGH'LIME FLY ASH A Thesis by CHUCK ALAN GREGORY Approved as to style and content by: Dr. ona d Saylak (Chairman f Committee) Dr. W. edbetter ( ember) (Member) r. Lloyd Deuel, 3...

  5. Ash Reduction of Corn Stover by Mild Hydrothermal Preprocessing

    SciTech Connect (OSTI)

    M. Toufiq Reza; Rachel Emerson; M. Helal Uddin; Garold Gresham; Charles J. Coronella

    2014-04-22

    Lignocellulosic biomass such as corn stover can contain high ash content, which may act as an inhibitor in downstream conversion processes. Most of the structural ash in biomass is located in the cross-linked structure of lignin, which is mildly reactive in basic solutions. Four organic acids (formic, oxalic, tartaric, and citric) were evaluated for effectiveness in ash reduction, with limited success. Because of sodium citrate’s chelating and basic characteristics, it is effective in ash removal. More than 75 % of structural and 85 % of whole ash was removed from the biomass by treatment with 0.1 g of sodium citrate per gram of biomass at 130 °C and 2.7 bar. FTIR, fiber analysis, and chemical analyses show that cellulose and hemicellulose were unaffected by the treatment. ICP–AES showed that all inorganics measured were reduced within the biomass feedstock, except sodium due to the addition of Na through the treatment. Sodium citrate addition to the preconversion process of corn stover is an effective way to reduced physiological ash content of the feedstock without negatively impacting carbohydrate and lignin content.

  6. Ash level meter for a fixed-bed coal gasifier

    DOE Patents [OSTI]

    Fasching, George E. (Morgantown, WV)

    1984-01-01

    An ash level meter for a fixed-bed coal gasifier is provided which utilizes the known ash level temperature profile to monitor the ash bed level. A bed stirrer which travels up and down through the extent of the bed ash level is modified by installing thermocouples to measure the bed temperature as the stirrer travels through the stirring cycle. The temperature measurement signals are transmitted to an electronic signal process system by an FM/FM telemetry system. The processing system uses the temperature signals together with an analog stirrer position signal, taken from a position transducer disposed to measure the stirrer position to compute the vertical location of the ash zone upper boundary. The circuit determines the fraction of each total stirrer cycle time the stirrer-derived bed temperature is below a selected set point, multiplies this fraction by the average stirrer signal level, multiplies this result by an appropriate constant and adds another constant such that a 1 to 5 volt signal from the processor corresponds to a 0 to 30 inch span of the ash upper boundary level. Three individual counters in the processor store clock counts that are representative of: (1) the time the stirrer temperature is below the set point (500.degree. F.), (2) the time duration of the corresponding stirrer travel cycle, and (3) the corresponding average stirrer vertical position. The inputs to all three counters are disconnected during any period that the stirrer is stopped, eliminating corruption of the measurement by stirrer stoppage.

  7. Cost of potential emerald ash borer damage in U.S. communities, 20092019 Kent F. Kovacs a,

    E-Print Network [OSTI]

    Liebhold, Andrew

    Analysis Cost of potential emerald ash borer damage in U.S. communities, 2009­2019 Kent F. Kovacs a Emerald ash borer Cost of ash treatment, removal, and replacement Emerald ash borer (Agrilus planipennis, Ontario in 2002. As of March 2009, isolated populations of emerald ash borer (EAB) have been detected

  8. Leaching of Mixtures of Biochar and Fly Ash

    SciTech Connect (OSTI)

    Palumbo, Anthony Vito; Porat, Iris; Phillips, Jana Randolph; Amonette, J. E.; Drake, Meghan M; Brown, Steven D; Schadt, Christopher Warren

    2009-01-01

    Increasing atmospheric levels of greenhouse gases, especially CO2, and their effects on global temperature have led to interest in the possibility of carbon storage in terrestrial environments.2, 5, 6 Both the residual char from biomass pyrolysis7-9, 12 (biochar) and fly ash from coal combustion1, 13, 14 have the potential to significantly expand terrestrial sequestration options. Both biochar and fly ash also have potentially beneficial effects on soil properties. Fly ash has been shown to increase porosity, water-holding capacity, pH, conductivity, and dissolved SO42-, CO32-, Cl- and basic cations.10, 11, 16 Adding biochar to soil generally raises pH, increases total nitrogen and total phosphorous, encourages greater root development, improves cation exchange capacity and reduces available aluminum.3, 17 Combinations of these benefits likely lead to the observed increased yields for crops including corn and sugarcane.17 with biochar addition to soil. In addition, it has been found that soils with added biochar emit lower amounts of other greenhouse gases (methane and nitrous oxide) 8, 17 than do unammended soils. Biochar and fly ash amendments may be useful in promoting terrestrial carbon sequestration on currently underutilized and degraded lands. For example, about 1% of the US surface lands consist of previously mined lands or highway rights-of-way.18 Poorly managed lands could count for another 15% of US area. Biochar and fly ash amendments could increase productivity of these lands and increase carbon storage in the soil Previous results showed minimal leaching of organic carbon and metals from a variety of fly ashes.15 Here, we are examining the properties of mixtures of biochar, fly ash, and soil and evaluating leaching of organic carbon and metals from the mixtures.

  9. Chloride chemical form in various types of fly ash

    SciTech Connect (OSTI)

    Fenfen Zhu; Masaki Takaoka; Kenji Shiota; Kazuyuki Oshita; Yoshinori Kitajima

    2008-06-01

    Chloride content is a critical problem for the reuse of fly ash as a raw material in cement, and the method used by recyclers to reduce the fly ash chloride content depends on the chemical form of the chlorides. However, limited information is available on the quantitative distribution of chlorides and the identity of some chlorides such as Friedel's salt. We examined chloride forms and percentages using X-ray absorption near edge structure and X-ray diffraction analyses, as well as corresponding washing experiments. Approximately 15% of the chlorine in raw fly ash was estimated to be in the form of NaCl, 10% in KCl, 50% in CaCl{sub 2}, and the remainder in the form of Friedel's salt. Fly ash collected in a bag filter with the injection of calcium hydroxide for acid gas removal (CaFA) contained 35% chlorine as NaCl, 11% as KCl, 37% as CaCl{sub 2}, 13% as Friedel's salt, and the remaining 4% as CaClOH. In fly ash collected in a bag filter with the injection of sodium bicarbonate for acid gas removal (NaFA), approximately 79% of chlorine was in NaCl, 12% was in KCl, and 9% was in Friedel's salt. 25 refs., 4 figs., 4 tabs.

  10. Release of Ammonium and Mercury from NOx Controlled Fly Ash

    SciTech Connect (OSTI)

    Schroeder, K.T.; Cardone, C.R.; Kim, A.G

    2007-07-01

    One of the goals of the Department of Energy is to increase the reuse of coal utilization byproducts (CUB) to 50% by 2010. This will require both developing new markets and maintaining traditional ones such as the use of fly ash in concrete. However, the addition of pollution control devices can introduce side-effects that affect the marketability of the CUB. Such can be the case when NOx control is achieved using selective catalytic or non-catalytic reduction (SCR or SNCR). Depending on site-specific details, the ammonia slip can cause elevated levels of NH3 in the fly ash. Disposal of ammoniated fly ash can present environmental concerns related to the amount of ammonia that might be released, the amount of water that might become contaminated, and the extent to which metals might be mobilized by the presence of the ammonia. Ammonia retained in fly ash appears to be present as either an ammonium salt or as a chemisorbed species. Mercury in the leachates correlated to neither the amount of leachable ammonium nor to the total amount of Hg in the ash. The strongest correlation was between the decreases in the amount of Hg leached with increased LOI.

  11. Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste

    E-Print Network [OSTI]

    Mailhes, Corinne

    Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from ash resulting from municipal solid waste incineration (MSWIBA percolate), using amphibian larvae waste incineration bottom ash; Percolate 1. Introduction Environmental management of municipal solid

  12. The Development and Use of the Berkeley Fluorescence Spectrometer to Characterize Microbial Content and Detect Volcanic Ash in Glacial Ice

    E-Print Network [OSTI]

    Rohde, Robert Andrew

    2010-01-01

    optical log of dust, ash, and stratigraphy in South PoleContent and Detect Volcanic Ash in Glacial Ice by RobertContent and Detect Volcanic Ash in Glacial Ice by Robert

  13. Ash bed level control system for a fixed-bed coal gasifier

    DOE Patents [OSTI]

    Fasching, George E. (Morgantown, WV); Rotunda, John R. (Fairmont, WV)

    1984-01-01

    An ash level control system is provided which incorporates an ash level meter to automatically control the ash bed level of a coal gasifier at a selected level. The ash level signal from the ash level meter is updated during each cycle that a bed stirrer travels up and down through the extent of the ash bed level. The ash level signal is derived from temperature measurements made by thermocouples carried by the stirrer as it passes through the ash bed and into the fire zone immediately above the ash bed. The level signal is compared with selected threshold level signal to determine if the ash level is above or below the selected level once each stirrer cycle. A first counter is either incremented or decremented accordingly. The registered count of the first counter is preset in a down counter once each cycle and the preset count is counted down at a selected clock rate. A grate drive is activated to rotate a grate assembly supporting the ash bed for a period equal to the count down period to maintain the selected ash bed level. In order to avoid grate binding, the controller provides a short base operating duration time each stirrer cycle. If the ash bed level drops below a selected low level or exceeds a selected high level, means are provided to notify the operator.

  14. Cementation and solidification of Rocky Flats Plant incinerator ash

    SciTech Connect (OSTI)

    Phillips, J.A.; Semones, G.B.

    1994-04-01

    Cementation studies on various aqueous waste streams at Rocky Flats have shown this technology to be effective for immobilizing the RCRA constituents in the waste. Cementation is also being evaluated for encapsulation of incinerator ash. Experiments will initially evaluate a surrogate ash waste using a Taguchi experimental design to optimize the cement formulation and waste loading levels for this application. Variables of waste loading, fly ash additions, water/cement ratio, and cement type will be tested at three levels each during the course of this work. Tests will finally be conducted on actual waste using the optimized cement formulation developed from this testing. This progression of tests will evaluate the effectiveness of cement encapsulation for this waste stream without generating any additional wastes.

  15. Ash reduction system using electrically heated particulate matter filter

    SciTech Connect (OSTI)

    Gonze, Eugene V; Paratore, Jr., Michael J; He, Yongsheng

    2011-08-16

    A control system for reducing ash comprises a temperature estimator module that estimates a temperature of an electrically heated particulate matter (PM) filter. A temperature and position estimator module estimates a position and temperature of an oxidation wave within the electrically heated PM filter. An ash reduction control module adjusts at least one of exhaust flow, fuel and oxygen levels in the electrically heated PM filter to adjust a position of the oxidation wave within the electrically heated PM filter based on the oxidation wave temperature and position.

  16. Continuous air agglomeration method for high carbon fly ash beneficiation

    DOE Patents [OSTI]

    Gray, McMahon L. (Pittsburgh, PA); Champagne, Kenneth J. (Monongahela, PA); Finseth, Dennis H. (Pittsburgh, PA)

    2000-01-01

    The carbon and mineral components of fly ash are effectively separated by a continuous air agglomeration method, resulting in a substantially carboree mineral stream and a highly concentrated carbon product. The method involves mixing the fly ash comprised of carbon and inorganic mineral matter with a liquid hydrocarbon to form a slurry, contacting the slurry with an aqueous solution, dispersing the hydrocarbon slurry into small droplets within the aqueous solution by mechanical mixing and/or aeration, concentrating the inorganic mineral matter in the aqueous solution, agglomerating the carbon and hydrocarbon in the form of droplets, collecting the droplets, separating the hydrocarbon from the concentrated carbon product, and recycling the hydrocarbon.

  17. High-performance, high-volume fly ash concrete

    SciTech Connect (OSTI)

    2008-01-15

    This booklet offers the construction professional an in-depth description of the use of high-volume fly ash in concrete. Emphasis is placed on the need for increased utilization of coal-fired power plant byproducts in lieu of Portland cement materials to eliminate increased CO{sub 2} emissions during the production of cement. Also addressed is the dramatic increase in concrete performance with the use of 50+ percent fly ash volume. The booklet contains numerous color and black and white photos, charts of test results, mixtures and comparisons, and several HVFA case studies.

  18. In memoriam, James Stephen “Steve” Ashe (1947–2005)

    E-Print Network [OSTI]

    Lingafelter, Steve; Anderson, Robert P.; Timm, Robert M.; Falin, Zack; Jameson, Mary Liz; Newton, Al; Ball, George; Ahn, Kee-Jeong; Leschen, Rich

    2006-02-01

    , ethical, and compassionate nature. He was the primary advisor of 11 students who received Ph.D. degrees (K.-J. Ahn, S. Chatzimanolis, J. Danoff-Burg, Z. Falin, R. Hanley, M. Jameson, C. Labandeira, R. Leschen, S. Lingafelter, G. Makranczy, and A. Slater...., and J. S. Ashe. 1991. The oxypodine genus Haploglossa Kraatz in North America (Coleoptera: Staphylinidae: Aleocharinae). Giornale Italiano di Entomologia 5:409–416. Ahn, K.-J., and J. S. Ashe. 1992. Revision of the intertidal aleocharine genus...

  19. THE ROLE OF FLY ASH IN CATALYTIC OXIDATION OF S(IV) SLURRIES

    E-Print Network [OSTI]

    Cohen, Sidney

    2014-01-01

    THE ROLE OF FLY ASH IN CATALYTIC OXIDATION OF S(IV) SLURRIESTHE ROLE OF FLY ASH IN CATALYTIC OXIDATION OF S(IV) SLURRIESreactive species in catalytic oxidation of S(IV). so 3 2- as

  20. Leaching and standing water characteristics of bottom ash and composted manure blends 

    E-Print Network [OSTI]

    Mathis, James Gregory

    2001-01-01

    Coal burning electrical generating facilities produce roughly 91 million metric tons of ash byproducts annually. Typically, this ash is retained at the power plant sites, adding to the cost of managing wastes at the plants. Another waste material...

  1. A Foreword for: Fearless Symmetry: Exposing the Hidden Patterns of Numbers by Avner Ash & Robert Gross

    E-Print Network [OSTI]

    Mazur, Barry

    A Foreword for: Fearless Symmetry: Exposing the Hidden Patterns of Numbers by Avner Ash & Robert that is being explained. Avner Ash and Robert Gross do a wonderful job at this balancing act in Fearless

  2. Non-Destructive X-ray Measurement of Soot, Ash, Washcoat and...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    X-ray Measurement of Soot, Ash, Washcoat and Regeneration Damage for DPFs Non-Destructive X-ray Measurement of Soot, Ash, Washcoat and Regeneration Damage for DPFs New commercially...

  3. Investigations of Game of Life cellular automata rules on Penrose Tilings: lifetime and ash

    E-Print Network [OSTI]

    Stepney, Susan

    Investigations of Game of Life cellular automata rules on Penrose Tilings: lifetime and ash; section 6 reports the statistics of lifetimes, ash densities, and growth of the region of activity. 2

  4. ForPeerReview Effect of Chemical Modification of Oil Fly Ash and

    E-Print Network [OSTI]

    Hussein, Ibnelwaleed A.

    ForPeerReview Effect of Chemical Modification of Oil Fly Ash and compatibilization Polymer Science #12;For Peer Review Figure 1: Fly ash grains at magnified view Page 1 of 47 John Wiley

  5. Geotechnical properties of fly and bottom ash mixtures for use in highway embankments

    SciTech Connect (OSTI)

    Kim, B.; Prezzi, M.; Salgado, R.

    2005-07-01

    Class F fly ash and bottom ash are the solid residue byproducts produced by coal-burning electric utilities. They are usually disposed of together as a waste in utility disposal sites with a typical disposal rate of 80% fly ash and 20% bottom ash. Direct use of these materials in construction projects consuming large volumes of materials, such as highway embankment construction, not only provides a promising solution to the disposal problem, but also an economic alternative to the use of traditional materials. Representative samples of class F fly and bottom ash were collected from two utility power plants in Indiana and tested for their mechanical properties (compaction, permeability, strength, stiffness, and compressibility). Three mixtures of fly and bottom ash with different mixture ratios (i.e., 50, 75, and 100% fly ash content by weight) were prepared for testing. Test results indicated that ash mixtures compare favorably with conventional granular materials.

  6. The Sensitivity of DPF Performance to the Spatial Distribution of Ash Generated from Six Lubricant Formulations

    Broader source: Energy.gov [DOE]

    Discusses potential of DPF pressure drop reduction by optimizing the spatial distribution of ash inside DPF inlet channel

  7. The variability of fly ash and its effects on selected properties of fresh Portland cement/fly ash mortars 

    E-Print Network [OSTI]

    McKerall, William Carlton

    1980-01-01

    for air content testing for 15 cubic feet of mortar per cubic yard of concrete 44 13 Summary of samples failing to meet ASTM C-618 uniformity specifications for specific gravity and fineness Average and relative rankings of flow, set, and air... of Energy (2). C Faber and Styron (9). Figure 2. Photomicrograph of' f'l y ash from sub-bituminous coal exposed to moisture ior seven days. 14 ~Sit'i ti ASTM recommends speci f1cat1ons for both class F and class C fly ashes (8). Tables 3 and 4 list...

  8. Conversion of oil shale ash into zeolite for cadmium and lead removal from wastewater

    E-Print Network [OSTI]

    Shawabkeh, Reyad A.

    Conversion of oil shale ash into zeolite for cadmium and lead removal from wastewater Reyad; available online 29 October 2003 Abstract A by-product fly ash from oil shale processing was converted shale; Ash; Zeolite; Cadmium and lead removal 1. Introduction Oil shale exists in Jordan with large

  9. Hydration and strength development of binder based on high-calcium oil shale fly ash

    SciTech Connect (OSTI)

    Freidin, C. [Ben-Gurion Univ. of the Negev, Sede-Boqer (Israel)] [Ben-Gurion Univ. of the Negev, Sede-Boqer (Israel)

    1998-06-01

    The properties of high-calcium oil shale fly ash and low-calcium coal fly ash, which are produced in Israeli power stations, were investigated. High-calcium oil shale fly ash was found to contain a great amount of CaO{sub free} and SO{sub 3} in the form of lime and anhydrite. Mixtures of high-calcium oil shale fly ash and low-calcium coal fly ash, termed fly ash binder, were shown to cure and have improved strength. The influence of the composition and curing conditions on the compressive strength of fly ash binders was examined. The microstructure and the composition of fly ash binder after curing and long-term exposure in moist air, water and open air conditions were studied. It was determined that ettringite is the main variable in the strength and durability of cured systems. The positive effect of calcium silicate hydrates, CSH, which are formed by interaction of high-calcium oil shale fly ash and low-calcium coal fly ash components, on the carbonation and dehydration resistance of fly ash binder in open air is pronounced. It was concluded that high-calcium oil shale fly ash with high CaO{sub free} and SO{sub 3} content can be used as a binder for building products.

  10. ORIGINAL PAPER Wood ash effects on nutrient dynamics and soil properties

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ORIGINAL PAPER Wood ash effects on nutrient dynamics and soil properties under Mediterranean aims to evaluate the effects of wood ash application on nutrient dynamics and soil properties of an acidic forest soil (Arenosol). & Methods Treatments were loose and pelleted ash application (11 Mg ha-1

  11. Airborne Volcanic Ash--A Global Threat to Aviation U.S. Department of the Interior

    E-Print Network [OSTI]

    Airborne Volcanic Ash--A Global Threat to Aviation U.S. Department of the Interior U.S. Geological on the aviation industry. Airborne volcanic ash can be a serious hazard to aviation even hundreds of miles from an eruption. Encounters with high-concentration ash clouds can diminish visibility, damage flight control

  12. Mt. Etna tropospheric ash retrieval and sensitivity analysis using Moderate Resolution Imaging

    E-Print Network [OSTI]

    Oxford, University of

    Mt. Etna tropospheric ash retrieval and sensitivity analysis using Moderate Resolution Imaging.pugnaghi@unimore.it, gabriele.gangale@unimore.it Abstract. A retrieval of tropospheric volcanic ash from Mt Etna has been. In order to derive the ash plume optical thickness, the particle effective radius and the total mass

  13. ASH: Tackling Node Mobility in Large-Scale Andrei Pruteanu, Stefan Dulman, Koen Langendoen

    E-Print Network [OSTI]

    Langendoen, Koen

    ASH: Tackling Node Mobility in Large-Scale Networks Andrei Pruteanu, Stefan Dulman, Koen Langendoen of a novel mechanism (called ASH) for the creation of a quasi-static overlay on top of a mobile topology. A preliminary evaluation by means of simulation shows that ASH succeeds in tackling node mobility, while

  14. A ash-drag effect in random motion reveals involvement of preattentive motion processing

    E-Print Network [OSTI]

    Whitney, David

    A ash-drag effect in random motion reveals involvement of preattentive motion processing Department-ku, Tokyo, JapanIkuya Murakami The ash-drag (FDE) effect refers to the phenomenon in which the position of a stationary ashed object in one location appears shifted in the direction of nearby motion. Over the past

  15. GEOPHYSICAL RESEARCH LETTERS, VOL. ???, XXXX, DOI:10.1029/, Hygroscopic Properties of Volcanic Ash

    E-Print Network [OSTI]

    Nenes, Athanasios

    GEOPHYSICAL RESEARCH LETTERS, VOL. ???, XXXX, DOI:10.1029/, Hygroscopic Properties of Volcanic Ash observational data exists on the physical interac- tions between volcanic ash particles and water vapor; yet it is thought that these interactions can strongly impact the microphysical evolution of ash, with implications

  16. 2015 Virginia Polytechnic Institute and State University ENTO-133NP Banded Ash Borer

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    2015 Virginia Polytechnic Institute and State University ENTO-133NP Banded Ash Borer Coleoptera Description Adult banded ash borers have somewhat cylindrical, elongated bodies ranging from 8­18 mm (0 unless infested wood is being split. Banded ash borer belongs to the cerambycid family of beetles. Adult

  17. ARTICLE IN PRESS Oxalate, calcium and ash intake and excretion balances in fat sand rats

    E-Print Network [OSTI]

    Vatnick, Itzick

    ARTICLE IN PRESS Oxalate, calcium and ash intake and excretion balances in fat sand rats (Psammomys and other inorganic matter (ash) intake and excretion in fat sand rats feeding on two different diets/3 of the ash content. In animals feeding on both diets, 65­80% of the oxalate ingested did not appear in urine

  18. SINGLE ELEMENT TEST PREDICTIONS FOR STRESS-STRAIN BEHAVIOR OF PANKI FLY-ASH

    E-Print Network [OSTI]

    Prashant, Amit

    1 SINGLE ELEMENT TEST PREDICTIONS FOR STRESS-STRAIN BEHAVIOR OF PANKI FLY-ASH M. Waseem1 , A: Fly-ash is a waste product produced by burning of coal at thermal power plants. It is often used as geo material for filling the low lying areas. Present study is conducted on F-class fly-ash from Panki

  19. Nitration of Benzo[a]pyrene Adsorbed on Coal Fly Ash Particles

    E-Print Network [OSTI]

    Dutta, Prabir K.

    Nitration of Benzo[a]pyrene Adsorbed on Coal Fly Ash Particles by Nitrogen Dioxide: Role of ThermalP) by nitrogen dioxide (NO2) adsorbed on the surface of thermally activated coal fly ash and model hydrocarbons on coal fly ash by reaction with nitrogen oxides can occur in the smokestack, but with the aging

  20. Influence of Loss-on-Ignition Temperature and Heating Time on Ash Content

    E-Print Network [OSTI]

    Selinger, Brent

    Influence of Loss-on-Ignition Temperature and Heating Time on Ash Content of Compost and Manure-on-ignition (LOI) is a simple method for determining ash content, and by reciprocation, organic matter content, 16, 20, and 24-h) on the ash content of a finished compost and a fresh manure. The experiment

  1. Experimental investigation of rates and mechanisms of isotope exchange (O, H) between volcanic ash and

    E-Print Network [OSTI]

    Bindeman, Ilya N.

    Experimental investigation of rates and mechanisms of isotope exchange (O, H) between volcanic ash-term exposure experi- ments of distal 7700 BP Mt. Mazama ash (À149& d2 H, +7& d18 O, 3.8 wt.% H2O and d2 H in native and reacted ash that can be used in defining the protocols for natural sample

  2. SO2 as a proxy for volcanic ash in aviation hazard avoidance

    E-Print Network [OSTI]

    Oxford, University of

    SO2 as a proxy for volcanic ash in aviation hazard avoidance Infrared Atmospheric Sounding Interferometer - IASI ABSTRACT: Airborne volcanic ash poses a significant danger to aircraft but is difficult accurately. This paper looks at the reliability of using SO2 as a proxy for the location of volcanic ash

  3. Measurement of the Optical Proper-ties of Volcanic Ash: Current status.

    E-Print Network [OSTI]

    Oxford, University of

    Measurement of the Optical Proper- ties of Volcanic Ash: Current status. Daniel M. Peters and R. G project "Opti- cal Properties of Volcanic ash". This project sets out to measure the extinction spectra and size distribution of volcanic ash aerosol. The measurements will allow the calculation of aerosol cross

  4. ASH: Application-aware SWANS with Highway Khaled Ibrahim and Michele C. Weigle

    E-Print Network [OSTI]

    Weigle, Michele

    ASH: Application-aware SWANS with Highway mobility Khaled Ibrahim and Michele C. Weigle Department simulator. Our SWANS modules, which we collectively call ASH (Application-aware SWANS with Highway mobility), make several contributions. ASH allows for the needed two-way communication between the mobility model

  5. In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents

    E-Print Network [OSTI]

    Schafer, William R.

    In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents di Genetica e Biofisica--ABT, Napoli, Italy ASH sensory neurons are required in Caenorhabditis and nose touch. The ASH neurons are therefore hypothesized to be polymodal nociceptive neurons

  6. Sentinel: Intelligent Information Sharing for Controlling the Emerald Ash Borer Threat

    E-Print Network [OSTI]

    Medjahed, Brahim

    Sentinel: Intelligent Information Sharing for Controlling the Emerald Ash Borer Threat Brahim - Dearborn 4901 Evergreen Road, Dearborn, MI 48120, USA {brahim,wgrosky}@umich.edu Abstract. The Emerald Ash Borer (EAB) has killed or infested millions of ash trees in Michigan and is fast spreading

  7. Surprising spread of volcanic ash key to solving Earth's mysteries: U of A grad

    E-Print Network [OSTI]

    Wang, Hao "Howard"

    Surprising spread of volcanic ash key to solving Earth's mysteries: U of A grad EDMONTON Volcanic ash, which can provide valuable snapshots of Earth's history, appears to drift much farther than of science that uses layers of "tephra," or ash, to link and date events in Earth's history. When a volcano

  8. Rheology and setting of high volume fly ash mixtures Dale P. Bentz *, Chiara F. Ferraris

    E-Print Network [OSTI]

    Bentz, Dale P.

    Rheology and setting of high volume fly ash mixtures Dale P. Bentz *, Chiara F. Ferraris Building technology High volume fly ash Hydration Rheology Set time Sustainability a b s t r a c t While high volume fly ash (HVFA) concretes can be designed and produced to meet 28-d strength requirements and often

  9. Advantageous GOES IR results for ash mapping at high latitudes: Cleveland eruptions 2001

    E-Print Network [OSTI]

    Bluth, Gregg

    Advantageous GOES IR results for ash mapping at high latitudes: Cleveland eruptions 2001 Yingxin Gu] The February 2001 eruption of Cleveland Volcano, Alaska allowed for comparisons of volcanic ash detection using angle also influences the results. The MODIS and AVHRR data give consistent retrievals of the ash cloud

  10. Role of Fungi in Postfire Stabilization of Chaparral Ash Beds1

    E-Print Network [OSTI]

    Role of Fungi in Postfire Stabilization of Chaparral Ash Beds1 Paul H. Dunn, Wade G. Wells II characteristic of thermo- philes. The heat-shock fungi in ash beds are adapted to the high ammonium and pH conditions of the ash and are capable of very rapid growth rates. They are, however, unable to compete

  11. Validation of IDM/MOBIL in ASH using Treiber's MicroApplet

    E-Print Network [OSTI]

    Weigle, Michele

    Validation of IDM/MOBIL in ASH using Treiber's MicroApplet Master's Project Final Report Author to acknowledge the work done by Khaled Ibrahim in creating the vehicular simulator ASH and helping me understand topologies and maps) and network models (concerns with the communication patterns between the vehicles). ASH

  12. Effect of particle size and volume fraction on tensile properties of fly ash/polyurea composites

    E-Print Network [OSTI]

    Nemat-Nasser, Sia

    Effect of particle size and volume fraction on tensile properties of fly ash/polyurea composites, 9500 Gilman Drive, La Jolla, CA 92093-0416, USA ABSTRACT Fly ash, which consists of hollow particles of the composites. The tensile properties of the pure polyurea and fly ash/polyurea (FA/PU) composites were tested

  13. GPS and Volcanic Ash Plumes: The eruptions of Okmok 2008 and Redoubt 2009, Alaska

    E-Print Network [OSTI]

    Grapenthin, Ronni

    GPS and Volcanic Ash Plumes: The eruptions of Okmok 2008 and Redoubt 2009, Alaska Ronni Grapenthin Volcano in 2008 and Mt. Redoubt in 2009 produced significant ash plumes reaching over 15 km of altitude. It is known that the injection of volcanic ash in the at- mosphere induces phase delays not modeled by GPS

  14. RAPID COMMUNICATION / COMMUNICATION RAPIDE Changes in ash tree demography associated with

    E-Print Network [OSTI]

    Liebhold, Andrew

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    E-Print Network [OSTI]

    Oxford, University of

    AO05: Ash detection and characterisation in IASI data Candidate number: 249038 Supervisors: Dr. E to distinguish volcanic ash from other airborne substances such as water clouds and desert dust. The method and by calculating their ratios and applying some conditions the ash affected pixels are found. A set

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    E-Print Network [OSTI]

    Thomas, David D.

    Potential impacts of emerald ash borer invasion on biogeochemical and water cycling in residential could threaten those services, with unknown environmental consequences. The outbreak of emerald ash borer is an imminent threat to the ash population in North America. In the Minneapolis­Saint Paul

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    E-Print Network [OSTI]

    Soskov, Ivan N.

    ASH'S THEOREM FOR ABSTRACT STRUCTURES I. N. SOSKOV AND V. BALEVA Abstract. We introduce and study In this paper we are going to prove an analog of Ash's Theorem 1] for abstract structures. We shall consider of generalization which is in the spirit of the Ash's Theorem 1]. Consider a set B Na. Suppose that you want to add

  18. 2015 Virginia Polytechnic Institute and State University ENTO-142NP Redheaded Ash Borer

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    2015 Virginia Polytechnic Institute and State University ENTO-142NP Redheaded Ash Borer Coleoptera Tech Description Adult redheaded ash borers have somewhat cylindrical, elongated bodies ranging from 4 are noticeably longer than the first pair. Overall, the shape, size, and coloration of the adult redheaded ash

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    Some Effects of Mt. St. Helens Volcanic Ash on Juvenile Salmon Smolts TIMOTHY W. NEWCOMB and THOMAS. Helens, which was completely decimated with vol- canic ash and mud slides. Heavy sediment loads smolts were exposed to various concentrations ofairborne volcanic ash from the 18 May 1980 eruption

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    E-Print Network [OSTI]

    Columbia University

    1 Review of WTE ash utilization processes under development in northwest Europe Athanasios. The main subject of his thesis is the transformation of waste-to-energy (WTE) bottom ash to higher value to advance beneficial uses of WTE ash. As part of this second part of his research, the author participated