National Library of Energy BETA

Sample records for beta court reporting

  1. Atkinson-Baker Court Reporters

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    depo.com Atkinson-Baker Court Reporters 1 1 U.S. DEPARTMENT OF ENERGY 2 PUBLIC SCOPING MEETING 3 4 ENVIRONMENTAL ASSESSMENT FOR THE ACCEPTANCE AND 5 DISPOSITION OF USED NUCLEAR FUEL CONTAINING 6 U.S.-ORIGIN HIGHLY ENRICHED URANIUM 7 FROM THE FEDERAL REPUBLIC OF GERMANY 8 9 DATE: February 4, 2016 10 7:04 p.m. 11 North Augusta Community Center 12 495 Brookside Avenue 13 North Augusta, SC 29841 14 15 16 Holmes Brown, Facilitator 17 Maxcine Maxted, Department of Energy, EA Document Manager 18

  2. Project Reports for Lac Courte Oreilles Band of Lake Superior Chippewa Indians- 2007 Project

    Broader source: Energy.gov [DOE]

    The Lac Courte Oreilles Band of Lake Superior Chippewa will gather and compile information on the tribe's energy use, conduct energy audits of reservation facilities, identify where conservation efforts would be worthwhile, and evaluate policy changes needed to implement conservation measures.

  3. Genetics in the courts

    SciTech Connect (OSTI)

    Coyle, Heather; Drell, Dan

    2000-12-01

    Various: (1)TriState 2000 Genetics in the Courts (2) Growing impact of the new genetics on the courts (3)Human testing (4) Legal analysis - in re G.C. (5) Legal analysis - GM ''peanots'', and (6) Legal analysis for State vs Miller

  4. Structure, Stoichiometry and Stability in Magnetoplumbite and {beta}-Alumina Structured Type Ceramics. Final Report

    SciTech Connect (OSTI)

    Cormack, A. N.

    2004-03-01

    Work has been completed on the atomistic simulation of hexa-aluminate ceramics with the magnetoplumbite and beta-alumina type structures. In this report, three aspects of the work are highlighted. One is the simulation of surface structures. The second concerns details of the interstitially mechanisms observed in molecular dynamics simulations. The novel result here is the observation that the lattice ion always leaves its Beevers-Ross site before the aBR interstitial begins to move towards the lattice site. It is also found that, as expected, the interstitial mechanism is the most common mechanism in the heavily disordered nonstoichiometric structure, as well as in the stoichiometric material. Finally, the disposition of trivalent europium in the phosphor material BAM has been elucidated.

  5. Comparison of COMETHE-IIIJ and FCODE-BETA fission gas-release predictions with measurements. Final report. [PWR; BWR

    SciTech Connect (OSTI)

    Lee, S.; Rayes, L.; Rumble, E.; Wheeler, D.; Woods, A.

    1983-03-01

    This report describes a comparison of the Fission Product Gas Release (FGR) predictability of two LWR fuel rod modeling codes: COMETHE-IIIJ and FCODE-BETA. The comparison is made using 124 well characterized fuel rods with FGR measurements in the EPRI Fuel Performance Data Base.

  6. Experimental studies of the early effects of inhaled beta-emitting radionuclides for nuclear accident risk assessment: Phase 2 report

    SciTech Connect (OSTI)

    Scott, B.R.; Hahn, F.F.; Newton, G.J.; Snipes, M.B.; Damon, E.G.; Mauderly, J.L.; Boecker, B.B.; Gray, D.H.

    1987-11-01

    This report summarizes a series of experiments concerning the effect of linear energy transfer and temporal radiation dose pattern to the lung from inhaled beta-emitting radionuclides. The results were used to test the validity of a hazard-function mathematical model for predicting death from radiation pneumonitis. Both morbidity and mortality within 18 months after exposure were examined in rats exposed to beta-emitting radionuclides, giving brief or protracted irradiation of the lung or having weak or strong beta emissions. Protraction of the radiation dose to the lung from a half-time in the lung of less than three days to a half-time with a long-term component of about 150 days has a sparing effect. The median lethal dose for the protracted irradiation is about 1.7 times the median lethal dose for the brief irradiation. Low energy beta emissions from /sup 147/Pm have a similar effectiveness in producing lethal injury as high energy beta emissions from /sup 90/Sr. Changes in three parameters of morbidity were measured: body weight, hematology and pulmonary function; only changes in pulmonary function correlated well with pulmonary radiation injury. The doses of radiation required to produce impaired function, however, were not significantly different from those that produced death. The hazard-function model for predicting death from radiation pneumonitis, which was developed from previously obtained data for inhalation exposures of dogs to beta-emitting radionuclides, adequately predicted the median lethal doses for rats receiving one of several different beta dose rate patterns to the lung, thus strengthening the validity of the mathematical model. 23 refs., 41 figs., 12 tabs.

  7. Assessment of SPEAR-FCODE-BETA for fuel licensing. Final report. [PWR; BWR

    SciTech Connect (OSTI)

    Bradley, E.R.; Lanning, D.D.; Fiero, I.B.; Freeburn, H.R.; Garde, A.M.; Krammen, M.A.; Rotondo, P.L.

    1983-03-01

    The EPRI FCODE-BETA fuel performance code is the mechanistic model portion for the SPEAR-BETA fuel reliability code, which was developed for EPRI by Entropy Limited. FCODE-BETA was assessed by Battelle, Pacific Northwest Laboratories, and Combustion Engineering, Inc., for adequacy in simulating fuel performance in fuel licensing proceedings. The assessment included a detailed review of those thermal and mechanical performance models of greatest importance to fuel licensing, including fission gas release, fuel temperatures, and cladding uniform strain. It was concluded that the code is inadequate for licensing calculations in its present form. Recommendations for modeling and usability improvements are made.

  8. Colorado Water Courts | Open Energy Information

    Open Energy Info (EERE)

    Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Colorado Water Courts Abstract This is the website for Colorado Water Courts. Author Colorado...

  9. SPEAR-BETA fuel performance code system. Volume 1. General description. Final report. [BWR; PWR

    SciTech Connect (OSTI)

    Christensen, R.

    1982-04-01

    This document provides a general description of the SPEAR-BETA fuel reliability code system. Included is a discussion of the methodology employed and the structure of the code system, as well as discussion of the major components: the data preparation routines, the mechanistic fuel performance model, the mechanistic cladding failure model, and the statistical failure model.

  10. Beta Radiation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Beta Radiation 1. Beta radiation may travel meters in air and is moderately penetrating. 2. Beta radiation can penetrate human skin to the "germinal layer," where new skin cells ...

  11. Lac Courte Oreilles Band - Energy Analysis

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Location of Lac Courte Oreilles * The Lac Courte Oreilles (LCO) Reservation is in Northern Wisconsin, 90 miles from Duluth, Minnesota and 11 miles from Hayward. About Lac Courte Oreilles * The reservation is presently 76,465 acres and is 15 miles wide. * We have a seven member Tribal Governing Board with four year terms. * LCO's membership is about 6,700 with nearly half of its members residing on or near the reservation * There are 25 distinctly different communities within the reservation for

  12. SPEAR-BETA fuel-performance code system: fission-gas-release module. Final report. [PWR; BWR

    SciTech Connect (OSTI)

    Christensen, R.

    1983-03-01

    The original SPEAR-BETA general description manual covers both mechanistic and statistical models for fuel reliability, but only mechanistic modeling of fission gas release. This addendum covers the SPEAR-BETA statistical model for fission gas release.

  13. Sustaining the natural and economical resources of the Lac Courte Oreilles, Leslie Isham; Jason Weaver

    SciTech Connect (OSTI)

    Isham, Leslie; Weaver, Jason

    2013-09-30

    The Lac Courte Oreilles Band of Lake Superior Chippewa Indians, located in northwest Wisconsin has developed a project, entitled Sustaining the Natural and Economic Resources of the LCO Ojibwe. This technical report is a summary of the project.

  14. Final Report for DUSEL R&D: BetaCage: A Screener of Ultra-Low-Level Radioactive Surface Contamination

    SciTech Connect (OSTI)

    Golwala, Sunil R.

    2013-12-20

    The eventual full-size, radiopure BetaCage will be a low-background, atmospheric-pressure neon drift chamber with unprecedented sensitivity to emitters of low-energy electrons and alpha particles. We expect that the prototype BetaCage already developed will be an excellent screener of alpha particles. Both the prototype and final BetaCage will provide new infrastructure for rare-event science.

  15. DOE Tour of Zero Floorplans: Chamberlain Court #75 by High Performance...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Chamberlain Court 75 by High Performance Homes DOE Tour of Zero Floorplans: Chamberlain Court 75 by High Performance Homes DOE Tour of Zero Floorplans: Chamberlain Court 75 by...

  16. Superfund awakes in state supreme courts

    SciTech Connect (OSTI)

    Sutherland, D.

    1998-01-01

    Superfund, often referred to as a sleeping giant, is waking up in state courts with rulings the insurance industry is on the hook for a large share of the nation`s environmental cleanup. While Congress has been quagmired in legislative reauthorization attempts, 40% of the state supreme courts (20 states) have passed laws favoring policyholders of comprehensive general liability insurance (CGL) to be compensated for their cleanup and litigation costs. These rulings vary in terms from state to state, but their collective action is giving the insurance industry grave concerns because of the increase in settlements with CGL policyholders.

  17. ARS 12 - Courts and Civil Proceedings | Open Energy Information

    Open Energy Info (EERE)

    ARS 12 - Courts and Civil Proceedings Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: ARS 12 - Courts and Civil ProceedingsLegal...

  18. Court decision dropping toxic substance rules stands

    SciTech Connect (OSTI)

    Bryant, C.R.

    1993-06-01

    In a somewhat surprising move, the U.S. Department of Labor has decided not to appeal a court decision essentially dropping regulations established by the Occupational Safety and Health Administration (OSHA) for about 400 hazardous substances. The decision leaves unregulated or subject to reduced standards substances that range from carbon monoxide to perchloroethylene. The Labor Department had until March 22, 1993, to appeal the court decision. On July 8, 1992, the U.S. Court of Appeals for the 11th Circuit overturned OSHA's final Air Contaminants Standard, which was promulgated in 1989. The standard established permissible exposure limits (PELs) for 428 toxic substances. In AFL-CIO vs. OSHA, the Court ruled that OSHA failed to make a separate scientific case for evaluating health risks of each chemical. Because of the decision not to appeal, PELs for more than half of the substances regulated by OSHA now are removed from the books or revert to the voluntary industry standards adopted by OSHA in 1970 and in force prior to the 1989 final rule.

  19. Lac Courte Oreilles Band of Lake Superior Ojibwe

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Oreilles Band of Lake Superior Ojibwe Leslie Isham, Director/Assistant Director Lac Courte Oreilles Energy Project Lac Courte Oreilles Public works Department First Steps towards Tribal Weatherization Assessing the Feasibility of the Hydro Dam About Lac Courte Oreilles (LCO) * Located in Upper Northwest Wisconsin * 76,000 acres and 15 miles wide * 90 miles from Duluth 100 miles from Eau Claire 10 miles from Hayward * Close to 6,000 members, 50% live on or near the reservation * 68% unemployment

  20. Lac Courte Oreilles Lake Superior Band of Ojibwe Energy Projects

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    OdaawaaZaga'iganing or Lac Courte Oreilles Lake Superior Band Of Ojibwe LCO Energy Department Staff: Director: Leslie Isham Coordinator: Denise Johnson Energy Projects: Assessing Hydro Dam First Steps Toward Tribal Weatherization Lac Courte Oreilles's Mission We, the Anishinaabeg, the people of OdaawaaZaaga'iganing, the Lac Courte Oreilles Tribe, will sustain our heritage by preserving our past, strengthening our present and embracing our future. We will defend our inherent sovereign rights and

  1. Cape May Court House, New Jersey: Energy Resources | Open Energy...

    Open Energy Info (EERE)

    County, New Jersey.1 Registered Energy Companies in Cape May Court House, New Jersey Cap May County Municipal Utilities Authority References US Census Bureau 2005 Place to...

  2. Winter Hydroelectric Dam Feasibility Assessment: The Lac Courte...

    Broader source: Energy.gov (indexed) [DOE]

    WINTER HYDROELECTRIC DAM FEASIBILITY ASSESSMENT THE LAC COURTE OREILLES BAND OF LAKE ... IN 1920 AND COMPLETED BY 1923 THE HYDROELECTRIC FACILITY WAS BUILT IN 1988. ISSUES ...

  3. In addition, the court properly has jurisdiction over a counterclaim...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    specific questions. In response to the Court's remand order, Bonneville commenced this administrative process. On May 6, 2015, Bonneville issued a notice requesting public...

  4. Assessing the Hydro Dam at Lac Courte Oreilles

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    "Assessing the Hydro Dam at Lac Courte Oreilles" Lac Courte Oreilles Band of Lake Superior Ojibwe Leslie Isham, Director, LCO Energy Project Assistant Director, LCO Public Works 9796N Cty. Hwy K Hayward, WI 54843 About Lac Courte Oreilles (LCO) * Located in upper Northwest Wisconsin * Land base is about 76,000 acres * 7,275 members * Adopted Kyoto Protocol in 2005 * Land Use Comprehensive Plan adopted in 2006 * 2008 DOE First Steps Grant Awarded LCO Tribal Mission We, the Anishinaabeg,

  5. Double Beta Decay Experiments

    SciTech Connect (OSTI)

    Nanal, Vandana [Dept. of Nuclear and Atomic Physics, Tata Institute of Fundamental Research, Mumbai 400 005 (India)

    2011-11-23

    At present, neutrinoless double beta decay is perhaps the only experiment that can tell us whether the neutrino is a Dirac or a Majorana particle. Given the significance of the 0{nu}{beta}{beta}, there is a widespread interest for these rare event studies employing a variety of novel techniques. This paper describes the current status of DBD experiments. The Indian effort for an underground NDBD experiment at the upcoming INO laboratory is also presented.

  6. Rapid synthesis of beta zeolites

    DOE Patents [OSTI]

    Fan, Wei; Chang, Chun -Chih; Dornath, Paul; Wang, Zhuopeng

    2015-08-18

    The invention provides methods for rapidly synthesizing heteroatom containing zeolites including Sn-Beta, Si-Beta, Ti-Beta, Zr-Beta and Fe-Beta. The methods for synthesizing heteroatom zeolites include using well-crystalline zeolite crystals as seeds and using a fluoride-free, caustic medium in a seeded dry-gel conversion method. The Beta zeolite catalysts made by the methods of the invention catalyze both isomerization and dehydration reactions.

  7. Leading the Charge: Doug MacCourt Advises Tribes on Energy Policy |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Doug MacCourt Advises Tribes on Energy Policy Leading the Charge: Doug MacCourt Advises Tribes on Energy Policy October 22, 2015 - 12:16pm Addthis MacCourt_Doug.jpg Leading the Charge is a regular feature spotlighting the movers and shakers in energy development on tribal lands. This issue we had the opportunity to speak with long-time Indian energy champion Doug MacCourt, who joined the DOE Office of Indian Energy as Senior Policy Advisor in July 2015. MacCourt has more

  8. Lac Courte Oreilles Hydro Dam Assessment

    SciTech Connect (OSTI)

    Weaver, Jason; Meyers, Amy

    2014-12-31

    The main objective of this project was to investigate upgrading the existing hydro power generating system at the Winter Dam. The tribe would like to produce more energy and receive a fair market power purchase agreement so the dam is no longer a drain on our budget but a contributor to our economy. We contracted Kiser Hydro, LLC Engineering for this project and received an engineering report that includes options for producing more energy with cost effective upgrades to the existing turbines. Included in this project was a negotiation of energy price sales negotiations.

  9. DOE PAGES Beta

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    portal to journal articles and accepted manuscripts resulting from DOE-funded research DOE PAGES Beta is the DOE response to the February 2013 White House Office of Science and...

  10. Download GETEM, August 2012 Beta | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Download GETEM, August 2012 Beta Download GETEM, August 2012 Beta

  11. U.S. District Court Upholds DOE's Action Against LG to Enforce ENERGY STAR

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Requirements | Department of Energy District Court Upholds DOE's Action Against LG to Enforce ENERGY STAR Requirements U.S. District Court Upholds DOE's Action Against LG to Enforce ENERGY STAR Requirements January 19, 2010 - 12:00am Addthis Washington, D.C. - On Monday, the United States District Court for the District of Columbia upheld the Department of Energy's decision to remove the ENERGY STAR® label from certain inefficient LG refrigerator-freezer models. As part of its expanded

  12. IO SUBSYSTEM 1 BETA

    Energy Science and Technology Software Center (OSTI)

    2002-08-21

    "IO Subsystem Ver. 1.0 Beta" uses standard object-oriented principles to minimize dependencies between the underlying input or output database format and the client code (i.e., Sierra) using the io subsystem. The interface and priciples are simolar to the Facade pattern described in the "Design Patterns" book by Gamma, et.al. The software uses data authentication algorithms to ensure data input/output is consistent with model being defined. "IO Subsystem Ver. 1.0 Beta" is a database independent input/outputmore » library for finite element analysis, preprocessing, post processing, and translation programs.« less

  13. U.S. District Court Upholds DOE's Action Against LG to Enforce...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The Court's Memorandum Opinion denied LG's motion for a preliminary injunction that would ... products under an exception to the energy use-test procedures used by other manufacturers. ...

  14. Trichoderma .beta.-glucosidase

    DOE Patents [OSTI]

    Dunn-Coleman, Nigel; Goedegebuur, Frits; Ward, Michael; Yao, Jian

    2006-01-03

    The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL3, recombinant BGL3 proteins and methods for producing the same.

  15. Supreme court agrees: FERC must regulate wholesale markets

    SciTech Connect (OSTI)

    Wolak, Frank A.

    2008-08-15

    The author believes that wholesale markets in the United States would have a greater likelihood of ultimately benefiting consumers if the Federal Energy Regulatory Commission did not have the mandate under the Federal Power Act (FPA) to ensure that wholesale prices are ''just and reasonable.'' However, he continues to believe that the FERC cannot avoid having an ex post criteria for asssessing whether market prices are just and reasonable. Moreover, changes in the design and regulatory oversight of U.S. wholesale electricity markets in recent years, including the recent Supreme Court decision, have caused him to believe even more strongly in the guardrails-for-market-outcomes approach. Finally, several questions are addressed which relate to the pricing of fixed-price, long-term contracts and the impact of these obligations on the behavior of suppliers in short-term wholesale markets that are directly relevant to answering the two major questions that the Supreme Court remanded to FERC in its recent decision.

  16. Level-2 Milestone 4468: Lorenz Simulation Interface Beta Release...

    Office of Scientific and Technical Information (OSTI)

    Title: Level-2 Milestone 4468: Lorenz Simulation Interface Beta Release Authors: Long, J W ; Martinez, J J Publication Date: 2012-01-23 OSTI Identifier: 1093932 Report Number(s): ...

  17. Beta* and beta-waist measurement and control at RHIC

    SciTech Connect (OSTI)

    Ptitsyn,V.; Della Penna, A.; Litvinenko, V.N.; Malitsky, N.; Satogata, T.

    2009-05-04

    During the course of last RHIC runs the beta-functions at the collision points ({beta}*) have been reduced gradually to 0.7m. In order to maximize the collision luminosity and ensure the agreement of the actual machine optics with the design one, more precise measurements and control of {beta}* value and {beta}-waist location became necessary. The paper presents the results of the implementation of the technique applied in last two RHIC runs. The technique is based on well-known relation between the tune shift and the beta function and involves precise betatron tune measurements using BBQ system as well as specially developed knobs for {beta}-waist location control.

  18. Solergy (Beta Version 1)

    Energy Science and Technology Software Center (OSTI)

    2009-03-30

    SOLERGY simulates the operation and power output of a user-defined solar central receiver power plant for a time period of up to one year. SOLERGY utilizes recorded or simulated weather data and plant component performance models to calculate the power flowing through each part of the solar plant. A plant control subroutine monitors these powers and determines when to operate the various plant subsystems. The original version of the code was released in May 1987,more » within SAND86-8060 and was widely distributed. The Beta Version 1 to be released in 2009, includes some relatively small modifications to the original code.« less

  19. Simultaneous beta and gamma spectroscopy

    DOE Patents [OSTI]

    Farsoni, Abdollah T.; Hamby, David M.

    2010-03-23

    A phoswich radiation detector for simultaneous spectroscopy of beta rays and gamma rays includes three scintillators with different decay time characteristics. Two of the three scintillators are used for beta detection and the third scintillator is used for gamma detection. A pulse induced by an interaction of radiation with the detector is digitally analyzed to classify the type of event as beta, gamma, or unknown. A pulse is classified as a beta event if the pulse originated from just the first scintillator alone or from just the first and the second scintillator. A pulse from just the third scintillator is recorded as gamma event. Other pulses are rejected as unknown events.

  20. BECCAV1.0 BETA

    Energy Science and Technology Software Center (OSTI)

    002318WKSTN00 Brain-Emulating Cognition and Control Architecture (BECCA) V1.0 beta http://sourceforge.net/projects/becca

  1. Court denies review of contractor/utility feud: contractors fear denial sets precedent

    SciTech Connect (OSTI)

    Poplett, J.

    1986-02-03

    On Jan. 27, the US Supreme Court refused to review a recent federal circuit court decision allowing a California public utility to enter into energy-related contractor activities; this may set a precedent for future related cases, according to an attorney for the contractor plaintiffs. The Supreme Court's refusal lets stand the 9th Federal Circuit Court of Appeals decision on Grason Electric Co. et al. vs. the Sacramento Municipal Utility District (SMUD). That decision allows SMUD - a public utility - to engage in energy-related businesses such as the installation of energy management systems and lighting retrofits, according to the attorney. The plaintiffs in the case, 13 electrical contractors in the Sacramento area, originally brought the case against SMUD on antitrust grounds because, they alleged, the utility was encroaching upon their businesses.

  2. Colorado - C.R.S. 40-6-115, Review by District Court | Open Energy...

    Open Energy Info (EERE)

    Colorado - C.R.S. 40-6-115, Review by District Court Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: Colorado - C.R.S. 40-6-115,...

  3. I.C. 62-6 - Procedure Before Commission and in Courts | Open...

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: I.C. 62-6 - Procedure Before Commission and in CourtsLegal Abstract This statute governs...

  4. MAJORANA Neutrinoless Double-Beta Decay DUSEL R&D

    SciTech Connect (OSTI)

    Wilkerson, John F.

    2009-09-04

    The Majorana research and development is addressing key issues and risks related to the collaboration's goal of undertaking a search for neutrinoless double-beta decay (0{nu}{beta}{beta}) in {sup 76}Ge using an array of hyper-pure Ge-diodes (HPGe). The observation of this decay would provide critical insight into our understanding of neutrinos, yielding definitive evidence that neutrinos are Majorana particles and providing information on the absolute mass of neutrinos. Achieving sensitivities to 0{nu}{beta}{beta} decay half-lives on the order of 10{sup 26} years requires ultra-low backgrounds in the 2039 keV region where a 0{nu}{beta}{beta} decay peak would be observed. The goal of our R&D program has been to demonstrate the feasibility of all components of Majorana and to provide an integrated evaluation framework, allowing for optimization of these components in terms of background, background suppression, and signal detection efficiency and acceptance. This report covers work carried out by Majorana collaboration members at the University of Washington as part of the overall Majorana collaboration activities. Specifically the Majorana group at the University of Washington was involved in moving forward on demonstrating technology for clean large-scale cryostats and mounting the HPGe crystals in low-mass holders. The UW activities included assistance in the procurement and assembly of an electroforming system for large size cryostats, and design and fabrication of prototype crystal mounting hardware.

  5. 0{nu}{beta}{beta}: The experimental challenge

    SciTech Connect (OSTI)

    Ferroni, Fernando [Sapienza Universita' and INFN Sezione di Roma, Roma I-00185 (Italy)

    2010-11-24

    This paper describes the main experimental issues related to neutrinoless double beta decay searches. It discusses, although briefly, the past, present and future of this exciting, fundamental but extremely complex field of research.

  6. Variants of beta-glucosidase

    DOE Patents [OSTI]

    Fidantsef, Ana; Lamsa, Michael; Gorre-Clancy, Brian

    2015-07-14

    The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

  7. Variants of beta-glucosidases

    DOE Patents [OSTI]

    Fidantsef, Ana; Lamsa, Michael; Gorre-Clancy, Brian

    2014-10-07

    The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

  8. Variants of beta-glucosidase

    DOE Patents [OSTI]

    Fidantsef, Ana; Lamsa, Michael; Gorre-Clancy, Brian

    2009-12-29

    The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

  9. Variants of beta-glucosidases

    DOE Patents [OSTI]

    Fidantsef, Ana; Lamsa, Michael; Clancy, Brian Gorre

    2008-08-19

    The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

  10. Beta particle monitor for surfaces

    DOE Patents [OSTI]

    MacArthur, D.W.

    1997-10-21

    A beta radiation detector which is capable of reliably detecting beta radiation emitted from a surface. An electrically conductive signal collector is adjustably mounted inside an electrically conductive enclosure which may define a single large opening for placing against a surface. The adjustable mounting of the electrically conductive signal collector can be based on the distance from the surface or on the expected beta energy range. A voltage source is connected to the signal collector through an electrometer or other display means for creating an electric field between the signal collector and the enclosure. Air ions created by the beta radiation are collected and the current produced is indicated on the electrometer or other display means. 2 figs.

  11. Beta-gamma discriminator circuit

    SciTech Connect (OSTI)

    Erkkila, B.H.; Wolf, M.A.; Eisen, Y.; Unruh, W.P.; Brake, R.J.

    1984-01-01

    The major difficulty encountered in the determination of beta-ray dose in field conditions is generally the presence of a relatively high gamma-ray component. Conventional dosimetry instruments use a shield on the detector to estimate the gamma-ray component in comparison with the beta-ray component. More accurate dosimetry information can be obtained from the measured beta spectrum itself. At Los Alamos, a detector and discriminator circuit suitable for use in a portable spectrometer have been developed. This instrument will discriminate between gammas and betas in a mixed field. The portable package includes a 256-channel MCA which can be programmed to give a variety of outputs, including a spectral display, and may be programmed to read dose directly.

  12. EIA - Eia.gov BETA

    Gasoline and Diesel Fuel Update (EIA)

    EIA is currently analyzing the feedback and will be making changes to this web product as ... testing of EIA experimental web products: User feedback of beta products is moderated. ...

  13. Neutrinoless double beta decay and neutrino masses

    SciTech Connect (OSTI)

    Duerr, Michael [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany)

    2012-07-27

    Neutrinoless double beta decay (0{nu}{beta}{beta}) is a promising test for lepton number violating physics beyond the standard model (SM) of particle physics. There is a deep connection between this decay and the phenomenon of neutrino masses. In particular, we will discuss the relation between 0{nu}{beta}{beta} and Majorana neutrino masses provided by the so-called Schechter-Valle theorem in a quantitative way. Furthermore, we will present an experimental cross check to discriminate 0{nu}{beta}{beta} from unknown nuclear background using only one isotope, i.e., within one experiment.

  14. Fundamental processes in the interacting boson model: 0{nu}{beta}{beta} decay

    SciTech Connect (OSTI)

    Iachello, F. [Center for Theoretical Physics, Sloane Physics Laboratory, Yale University, New Haven, CT 06520-8120 (United States); Barea, J. [Departamento de Fisica, Universidad de Concepcion, Casilla 160-C, Concepcion (Chile)

    2011-05-06

    A program to calculate nuclear matrix elements for fundamental processes in the interacting boson model has been initiated. Results for the nuclear matrix elements in neutrinoless double beta decay 0{nu}{beta}{beta} are presented.

  15. DOE Tour of Zero: Chamberlain Court #75 by High Performance Homes |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Chamberlain Court #75 by High Performance Homes DOE Tour of Zero: Chamberlain Court #75 by High Performance Homes 1 of 26 High Performance Homes built this 6,869-square-foot home in Gettysburg, Pennsylvania, to the performance criteria of the U.S. Department of Energy Zero Energy Ready Home (ZERH) program. 2 of 26 The 6.25-kW solar electric system uses roof-integrated photovoltaic shingles for a low profile and contributes to reducing utility bills by nearly $4,000

  16. Lac Courte Oreilles Band of Lake Superior Chippewa Indians - Energy Analysis

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Oreilles Band of Lake Superior Ojibwe Location of Lac Courte Oreilles About Lac Courte Oreilles (LCO) * The reservation is presently 76,465 acres and is 15 miles wide. * We have a seven member Tribal Governing Board with four year terms. * LCO's membership is about 7,000 with nearly half of its members residing on or near the reservation * There are 25 distinctly different communities within the reservation for a total of 1,019 households (2000 Census). * LCO operates two casinos; recently

  17. BETA-GAMMA PERSONNEL DOSIMETER

    DOE Patents [OSTI]

    Davis, D.M.; Gupton, E.D.; Hart, J.C.; Hull, A.P.

    1961-01-17

    A personnel dosimeter is offered which is sensitive to both gamma and soft beta radiations from all directions within a hemisphere. The device is in the shape of a small pill box which is worn on a worker-s wrist. The top and sides of the device are provided with 50 per cent void areas to give 50 per cent response to the beta rays and complete response to the gamma rays. The device is so constructed as to have a response which will approximate the dose received by the basal layer of the human epidermis.

  18. Beta ray flux measuring device

    DOE Patents [OSTI]

    Impink, Jr., Albert J.; Goldstein, Norman P.

    1990-01-01

    A beta ray flux measuring device in an activated member in-core instrumentation system for pressurized water reactors. The device includes collector rings positioned about an axis in the reactor's pressure boundary. Activated members such as hydroballs are positioned within respective ones of the collector rings. A response characteristic such as the current from or charge on a collector ring indicates the beta ray flux from the corresponding hydroball and is therefore a measure of the relative nuclear power level in the region of the reactor core corresponding to the specific exposed hydroball within the collector ring.

  19. New Limit on Time-Reversal Violation in Beta Decay

    SciTech Connect (OSTI)

    Mumm, H. P.; Chupp, T. E.; Cooper, R. L.; Coulter, K. P.; Freedman, S. J.; Fujikawa, B. K.; Garcia, A.; Jones, G. L.; Nico, J. S.; Thompson, A. K.; Trull, C. A.; Wietfeldt, F. E.; Wilkerson, J. F.

    2011-09-02

    We report the results of an improved determination of the triple correlation DP{center_dot}(p{sub e}xp{sub v}) that can be used to limit possible time-reversal invariance in the beta decay of polarized neutrons and constrain extensions to the standard model. Our result is D=[-0.96{+-}1.89(stat){+-}1.01(sys)]x10{sup -4}. The corresponding phase between g{sub A} and g{sub V} is {phi}{sub AV}=180.013 deg. {+-}0.028 deg. (68% confidence level). This result represents the most sensitive measurement of D in nuclear {beta} decay.

  20. Lac Courte Oreilles Band of Lake Superior Chippewa Indians- 2007 Project

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Lac Courte Oreilles Band of Lake Superior Chippewa will gather and compile information on the tribe's energy use, conduct energy audits of reservation facilities, identify where conservation efforts would be worthwhile, and evaluate policy changes needed to implement conservation measures.

  1. Searches for massive neutrinos in nuclear beta decay

    SciTech Connect (OSTI)

    Jaros, J.A.

    1992-10-01

    The status of searches for massive neutrinos in nuclear beta decay is reviewed. The claim by an ITEP group that the electron antineutrino mass > 17eV has been disputed by all the subsequent experiments. Current measurements of the tritium beta spectrum limit m{sub {bar {nu}}e} < 10 eV. The status of the 17 keV neutrino is reviewed. The strong null results from INS Tokyo and Argonne, and deficiencies in the experiments which reported positive effects, make it unreasonable to ascribe the spectral distortions seen by Simpson, Hime, and others to a 17keV neutrino. Several new ideas on how to search for massive neutrinos in nuclear beta decay are discussed.

  2. Neutron Beta Decay Studies with Nab

    SciTech Connect (OSTI)

    Baessler, S.; Alarcon, R.; Alonzi, L. P.; Balascuta, S.; Barron-Palos, L.; Bowman, James David; Bychkov, M. A.; Byrne, J.; Calarco, J; Chupp, T.; Cianciolo, T. V.; Crawford, C.; Frlez, E.; Gericke, M. T.; Glück, F.; Greene, G. L.; Grzywacz, R. K.; Gudkov, V.; Harrison, D.; Hersman, F. W.; Ito, T.; Makela, M.; Martin, J.; McGaughey, P. L.; McGovern, S.; Page, S.; Penttila, Seppo I; Pocanic, Dinko; Salas-Bacci, A.; Tompkins, Z.; Wagner, D.; Wilburn, W. S.; Young, A. R.

    2013-01-01

    Precision measurements in neutron beta decay serve to determine the coupling constants of beta decay and allow for several stringent tests of the standard model. This paper discusses the design and the expected performance of the Nab spectrometer.

  3. SUTTIP V.0.1 BETA

    Energy Science and Technology Software Center (OSTI)

    002915WKSTN00 Sandia Unstructured Triangle Tabular Interpolation Package v 0.1 beta ihttps://software.sandia.gov/

  4. Polypeptides having beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same

    SciTech Connect (OSTI)

    Morant, Marc Dominique

    2014-05-06

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  5. Polypeptides having beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same

    DOE Patents [OSTI]

    Morant, Marc Dominique

    2014-04-29

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  6. Polypeptides having beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same

    DOE Patents [OSTI]

    Morant, Marc Dominique

    2014-05-06

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  7. Characteristics of beta detection and dose measurement at Department of Energy facilities

    SciTech Connect (OSTI)

    Mulvehill, J.M.; Brackenbush, L.W.

    1987-02-01

    This report considers the current state of the art of beta dosimetry practices and beta detection methods used by health physicists at US Department of Energy facilities. This information is based on a survey of DOE facilities. Beta measurements are technically difficult and innovative efforts must be expended to improve their accuracy. Perhaps the most pronounced problem is that beta dosimetry and instrumentation in use are highly energy and angular dependent. Many believe that beta exposures are adequately controlled because beta to photon ratios are assumed to be low. This assumption is not always valid as demonstrated by the accident at Three Mile Island (TMI). Significant beta doses exist where personnel are exposed to mixed fission products; for example, chemical reprocessing plants, reactor accidents, or where uranium metals are processed. This report is part of an effort to increase the DOE response to this technically difficult area of health protection. Problem areas are addressed and methods recommended to improve beta dosimetry through a cooperative effort among the various DOE contractors. 34 refs., 2 figs., 16 tabs.

  8. Development of Cryogenic Bolometer for 0{nu}{beta}{beta} in {sup 124}Sn

    SciTech Connect (OSTI)

    Singh, Vivek; Mathimalar, S.; Dokania, Neha [INO, Tata Institute of Fundamental Research, Mumbai 400 005 (India); Yashwant, G.; Nanal, V.; Pillay, R. G. [Dept. of Nuclear and Atomic Physics, Tata Institute of Fundamental Research, Mumbai 400 005 (India); Datar, V. M. [Nuclear Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India)

    2011-11-23

    Cryogenic bolometer detectors, with their high resolution spectroscopy capability, are ideal for neutrino mass experiments as well as for search of rare processes like neutrinoless double beta decay (0{nu}{beta}{beta}) and dark matter. A feasibility study for investigation of 0{nu}{beta}{beta} in {sup 124}Sn at the upcoming underground facility of India based Neutrino Observatory (INO) has been initiated. This paper describes endeavors towards cryogenic tin bolometer development.

  9. 0v{beta}{beta} decay: theoretical nuclear matrix elements and their covariances

    SciTech Connect (OSTI)

    Lisi, Eligio [Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Via Orabona 4, 70126 Bari (Italy)

    2009-11-09

    Within the quasiparticle random phase approximation (QRPA), the covariances associated to the nuclear matrix elements (NME) of neutrinoless double beta decay (0v{beta}{beta}) are estimated. It is shown that correlated NME uncertainties play an important role in the comparison of 0v{beta}{beta} decay rates for different nuclei, both in the standard case of light Majorana neutrino exchange, and in nonstandard physics cases.

  10. EIA - Eia.gov BETA

    U.S. Energy Information Administration (EIA) Indexed Site

    Eia.gov BETA - U.S. Energy Information Administration (EIA) - U.S. Energy Information Administration (EIA) U.S. Energy Information Administration - EIA - Independent Statistics and Analysis Sources & Uses Petroleum & Other Liquids Crude oil, gasoline, heating oil, diesel, propane, and other liquids including biofuels and natural gas liquids. Natural Gas Exploration and reserves, storage, imports and exports, production, prices, sales. Electricity Sales, revenue and prices, power plants,

  11. IRS (Internal Revenue Service) claim against oil firms heads for a court showdown

    SciTech Connect (OSTI)

    Not Available

    1990-09-24

    During the gasoline crisis of the late Seventies, Saudi Arabia pumped oil to four U.S. oil companies at a price mutually agreed on. But the Internal Revenue Service says the companies sold the oil at a higher rate, raking in profits that they must pay taxes on. Exxon and Texaco dispute the ruling, while the other companies are being audited. The Tax Court is scheduled to try the case April of 1991.

  12. Environmental Impact Assessment Law in China's courts: A study of 107 judicial decisions

    SciTech Connect (OSTI)

    Zining, Jin

    2015-11-15

    The article explores the practices of Environmental Impact Assessment (EIA) Law in China's courts by examining 107 judicial decisions. Each of the 107 judicial decisions has been analyzed to determine the time/location of the decision, what type of EIA document was referred to, what specific claim was made by the plaintiffs, and what the court's ruling was on the case. The results indicate that: unlike in Germany or Japan, all kinds of EIA decisions made by environment protect bureaus (EPBs) in China were widely taken as justiciable, and China's courts generally allowed local residents to have standing and thus challenge the EPBs' decisions made during the EIA process. On the other hand, the research also shows the EPBs overwhelmingly prevailed in those EIA lawsuits. It is also found that China's reviewing judges were highly self-restrained, giving obvious deference to the technocrat with the substantial contents of EIA documents. Also, the concept of “flaw” was created when it came to procedural issues. These two factors, among others, were both helping the EPBs' prevailing successes. - Highlights: • 107 judicial decisions referring to China's EIA law are examined. • The justiciability of EPB's EIA decisions were taken for granted. • The defenders overwhelmingly prevailed in those EIA lawsuits. • The reviewing judges were highly self-restrained, defering to the technocrat with the EIA documents. • A functional concept, “flaw”, was created by reviewing judges when it came to procedural issues.

  13. Project Reports for Lac Courte Oreilles Band of Lake Superior Chippewa Indians- 2010 Project

    Broader source: Energy.gov [DOE]

    This weatherization training will result in a reduction of the use and cost of energy by increasing the number of homes that are weatherized.

  14. Project Reports for Lac Courte Oreilles Band of Lake Superior Chippewa Indians- 2010 Project

    Office of Energy Efficiency and Renewable Energy (EERE)

    The feasibility study of hydropower will answer three questions: 1) How can hydropower be developed to create a sustainable economic stream that contributes to the financial viability of the tribe? 2) How can this venture meet the energy needs of the community? 3) How can hydropower be developed without jeopardizing Mother Earth or the cultural beliefs of the tribe?

  15. Relationship of the percentage depletion allowance and the dividends received deduction: a disagreement with the tax court

    SciTech Connect (OSTI)

    Orbach, K.N.

    1983-09-01

    Arguments against the Tax Court's holding in Lastarmo, Inc. v. Commissioner review the equations for solving the percentage depletion deduction (PD) and dividends received deduction (DRD) interrelationship to determine whether a corporate taxpayer has had a net operating loss (NOL). The Tax Court sought to fill a perceived gap in Internal Revenue Service statutory framework which the author considers invalid because of the calculations used to prove NOL. His calculations show that none existed. 48 references. (DCK)

  16. Beta

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and developer tool on the Energy.gov Open Energy Data site and a training resource on the DOE Virtual University, the Department's online workforce development and training center. ...

  17. Method for preparing Pb-. beta. ''-alumina ceramic

    DOE Patents [OSTI]

    Hellstrom, E.E.

    1984-08-30

    A process is disclosed for preparing impermeable, polycrystalline samples of Pb-..beta..''-alumina ceramic from Na-..beta..''-alumina ceramic by ion exchange. The process comprises two steps. The first step is a high-temperature vapor phase exchange of Na by K, followed by substitution of Pb for K by immersing the sample in a molten Pb salt bath. The result is a polycrystalline Pb-..beta..''-alumina ceramic that is substantially crack-free.

  18. Beta cell device using icosahedral boride compounds

    DOE Patents [OSTI]

    Aselage, Terrence L.; Emin, David

    2002-01-01

    A beta cell for converting beta-particle energies into electrical energy having a semiconductor junction that incorporates an icosahedral boride compound selected from B.sub.12 As.sub.2, B.sub.12 P.sub.2, elemental boron having an .alpha.-rhombohedral structure, elemental boron having a .beta.-rhombohedral structure, and boron carbides of the chemical formula B.sub.12-x C.sub.3-x, where 0.15beta radiation source, and means for transmitting electrical energy to an outside load. The icosahedral boride compound self-heals, resisting degradation from radiation damage.

  19. BECCA V0.1 BETA

    Energy Science and Technology Software Center (OSTI)

    002399MLTPL00 Brain-Emulating Cognition and Control Architecture (BECCA) v. 0.2 beta http://becca.sourceforge.net

  20. The nuclear matrix elements for neutrinoless double beta decay

    SciTech Connect (OSTI)

    Simkovic, Fedor [Department of Nuclear Physics and Biophysics, Comenius University, Mlynska dolina, SK-84248 Bratislava (Slovakia)

    2007-10-12

    The status of calculation of the neutrinoless double beta decay (0{nu}{beta}{beta}-decay) nuclear matrix elements (NME's) is reviewed. The spread of published values of NME's is discussed. The main attention is paid to the recent progress achieved in the evaluation of the 0{nu}{beta}{beta}-decay NME's in the framework of the quasiparticle random phase approximation (QRPA). The obtained results are compared with those of the nuclear shell model. The problem of reliable determination of the 0{nu}{beta}{beta}-decay NME's is addressed. The uncertainty in NME's are analyzed and further progress in calculation of the 0{nu}{beta}{beta}-decay NME's is outlined.

  1. Neutrinoless double beta decay and nuclear matrix elements

    SciTech Connect (OSTI)

    Simkovic, Fedor [BLTP, JINR Dubna, 141980 Dubna, Moscow region (Russian Federation); Comenius University, Mlynska dolina, Bratislava (Slovakia)

    2011-11-23

    The fundamental importance of searching for neutrinoless double-beta decay (0{nu}{beta}{beta}-decay) is widely recognized. Observation of the decay would tell us that the total lepton number is not conserved and that, consequently, neutrinos are massive Majorana fermions. The 0{nu}{beta}{beta}-decay is discussed in context of neutrino oscillation data. The perspectives of the experimental 0{nu}{beta}{beta}-decay searches are analyzed. The importance of reliable determination of the 0{nu}{beta}{beta}-decay nuclear matrix elements is pointed out.

  2. Imperfect World of beta beta-decay Nuclear Data Sets

    SciTech Connect (OSTI)

    Pritychenko, B.

    2015-01-03

    The precision of double-beta ββ-decay experimental half lives and their uncertainties is reanalyzed. The method of Benford's distributions has been applied to nuclear reaction, structure and decay data sets. First-digit distribution trend for ββ-decay T2v1/2 is consistent with large nuclear reaction and structure data sets and provides validation of experimental half-lives. A complementary analysis of the decay uncertainties indicates deficiencies due to small size of statistical samples, and incomplete collection of experimental information. Further experimental and theoretical efforts would lead toward more precise values of-decay half-lives and nuclear matrix elements.

  3. Results from the Cuoricino (Zero-Neutrino Double Beta) Decay Experiment

    SciTech Connect (OSTI)

    Arnaboldi, C; Artusa, D R; Avignone, F T; Balata, M; Bandac, I; Barucci, M; Beeman, J W; Bellini, F; Brofferio, C; Bucci, C; Capelli, S; Carbone, L; Cebrian, S; Clemenza, M; Cremonesi, O; Creswick, R J; de Ward, A; Didomizio, S D; Dolinski, M J; Farach, H A; Fiorini, E; Frossati, G; Giachero, A; Giuliani, A; Gorla, P; Guardincerri, E; Gutierrez, T D; Haller, E E; Maruyama, R H; McDonald, R J; Nisi, S; Nones, C; Norman, E B; Nucciotti, A; Olivieri, E; Pallavicini, M; Palmieri, E; Pasca, E; Pavan, M; Pedretti, M; Pessina, G; Pirro, S; Previtali, E; Risegari, L; Rosenfeld, C; Sangiorgio, S; Sisti, M; Smith, A R; Torres, L; Ventura, G; Vignati, M

    2007-12-20

    Recent results from the CUORICINO {sup 130}Te zero-neutrino double-beta (0v{beta}{beta}) decay experiment are reported. CUORICINO is an array of 62 tellurium oxide (TeO{sub 2}) bolometers with an active mass of 40.7 kg. It is cooled to {approx}8 mK by a dilution refrigerator shielded from environmental radioactivity and energetic neutrons. It is running in the Laboratori Nazionali del Gran Sasso (LNGS) in Assergi, Italy. These data represent 11.83 kg y or 90.77 mole-years of {sup 130}Te. No evidence for 0v{beta}{beta}-decay was observed and a limit of T{sub 1/2}{sup 0v} ({sup 130}Te) {ge} 3.0 x 10{sup 24} y (90% C.L.) is set. This corresponds to upper limits on the effective mass, , between 0.19 and 0.68eV when analyzed with the many published nuclear structure calculations. In the context of these nuclear models, the values fall within the range corresponding to the claim of evidence of 0v{beta}{beta}-decay by H.V. Klapdor-Kleingrothaus and his co-workers. The experiment continues to acquire data.

  4. Gamma-ray blind beta particle probe

    DOE Patents [OSTI]

    Weisenberger, Andrew G.

    2001-01-01

    An intra-operative beta particle probe is provided by placing a suitable photomultiplier tube (PMT), micro channel plate (MCP) or other electron multiplier device within a vacuum housing equipped with: 1) an appropriate beta particle permeable window; and 2) electron detection circuitry. Beta particles emitted in the immediate vicinity of the probe window will be received by the electron multiplier device and amplified to produce a detectable signal. Such a device is useful as a gamma insensitive, intra-operative, beta particle probe in surgeries where the patient has been injected with a beta emitting radiopharmaceutical. The method of use of such a device is also described, as is a position sensitive such device.

  5. Process for reducing beta activity in uranium

    DOE Patents [OSTI]

    Briggs, Gifford G.; Kato, Takeo R.; Schonegg, Edward

    1986-10-07

    This invention is a method for lowering the beta radiation hazards associated with the casting of uranium. The method reduces the beta radiation emitted from the as-cast surfaces of uranium ingots. The method also reduces the amount of beta radiation emitters retained on the interiors of the crucibles that have been used to melt the uranium charges and which have undergone cleaning in a remote handling facility. The lowering of the radioactivity is done by scavenging the beta emitters from the molten uranium with a molten mixture containing the fluorides of magnesium and calcium. The method provides a means of collection and disposal of the beta emitters in a manner that reduces radiation exposure to operating personnel in the work area where the ingots are cast and processed.

  6. Process for reducing beta activity in uranium

    DOE Patents [OSTI]

    Briggs, G.G.; Kato, T.R.; Schonegg, E.

    1985-04-11

    This invention is a method for lowering the beta radiation hazards associated with the casting of uranium. The method reduces the beta radiation emitted from the as-cast surfaces of uranium ingots. The method also reduces the amount of beta radiation emitters retained on the interiors of the crucibles that have been used to melt the uranium charges and which undergone cleaning in a remote handling facility. The lowering of the radioactivity is done by scavenging the beta emitters from the molten uranium with a molten mixture containing the fluorides of magnesium and calcium. The method provides a means of collection and disposal of the beta emitters in a manner that reduces radiation exposure to operating personnel in the work area where the ingots are cast and processed. 5 tabs.

  7. Process for reducing beta activity in uranium

    DOE Patents [OSTI]

    Briggs, Gifford G.; Kato, Takeo R.; Schonegg, Edward

    1986-01-01

    This invention is a method for lowering the beta radiation hazards associated with the casting of uranium. The method reduces the beta radiation emitted from the as-cast surfaces of uranium ingots. The method also reduces the amount of beta radiation emitters retained on the interiors of the crucibles that have been used to melt the uranium charges and which have undergone cleaning in a remote handling facility. The lowering of the radioactivity is done by scavenging the beta emitters from the molten uranium with a molten mixture containing the fluorides of magnesium and calcium. The method provides a means of collection and disposal of the beta emitters in a manner that reduces radiation exposure to operating personnel in the work area where the ingots are cast and processed.

  8. Fact Sheet: Sodium-Beta Batteries (October 2012)

    Broader source: Energy.gov (indexed) [DOE]

    Sodium-beta batteries (Na-beta batteries or NBBs) use a solid beta-alumina (-Al 2 O 3 ) electrolyte membrane that selectively allows sodium ion transport between a positive ...

  9. Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Submittal Letter (pdf) Appendix A (xls) AnchoChaquehui Watershed PCB Report Polychlorinated Biphenyls in Precipitation and Stormwater within the Upper Rio Grande Watershed (pdf) ...

  10. Majorana DUSEL R&D Final Report

    SciTech Connect (OSTI)

    Fast, James E.; Hoppe, Eric W.; Mintzer, Esther E.; Aalseth, Craig E.; Day, Anthony R.; Gerlach, David C.; Farmer, Orville T.; Liezers, Martin; Lepel, Elwood A.; Miley, Harry S.; Edwards, Danny J.

    2010-09-21

    This report summarizes the work performed at PNNL under the project Majorana Neutrinoless Double Beta Decay DUSEL R&D over the period of FY07-FY09.

  11. SciTech Connect: "neutrinoless double beta decay"

    Office of Scientific and Technical Information (OSTI)

    neutrinoless double beta decay" Find + Advanced Search Term Search Semantic Search Advanced Search All Fields: "neutrinoless double beta decay" Semantic Semantic Term Title:...

  12. tan{beta}-enhanced supersymmetric corrections to the anomalous magnetic moment of the muon

    SciTech Connect (OSTI)

    Marchetti, Schedar; Mertens, Susanne; Nierste, Ulrich; Stoeckinger, Dominik

    2009-01-01

    We report on a two-loop supersymmetric contribution to the magnetic moment (g-2){sub {mu}} of the muon which is enhanced by two powers of tan{beta}. This contribution arises from a shift in the relation between the muon mass and Yukawa coupling and can increase the supersymmetric contribution to (g-2){sub {mu}} sizably. As a result, if the currently observed 3{sigma} deviation between the experimental and SM theory value of (g-2){sub {mu}} is analyzed within the minimal supersymmetric standard model (MSSM), the derived constraints on the parameter space are modified significantly: If (g-2){sub {mu}} is used to determine tan{beta} as a function of the other MSSM parameters, our corrections decrease tan{beta} by roughly 10% for tan{beta}=50.

  13. Solid-state NMR analysis of the {beta}-strand orientation of the protofibrils of amyloid {beta}-protein

    SciTech Connect (OSTI)

    Doi, Takashi; Masuda, Yuichi; Irie, Kazuhiro; Akagi, Ken-ichi; Monobe, Youko; Imazawa, Takayoshi; Takegoshi, K.

    2012-11-30

    Highlights: Black-Right-Pointing-Pointer The supramolecular structure of A{beta}42 protofibrils was analyzed by solid-state NMR. Black-Right-Pointing-Pointer The Ala-21 residue in the A{beta}42 protofibrils is included in a slightly disordered {beta}-strand. Black-Right-Pointing-Pointer The A{beta}42 protofibrils do not form intermolecular in-register parallel {beta}-sheets. -- Abstract: Alzheimer's disease (AD) is caused by abnormal deposition (fibrillation) of a 42-residue amyloid {beta}-protein (A{beta}42) in the brain. During the process of fibrillation, the A{beta}42 takes the form of protofibrils with strong neurotoxicity, and is thus believed to play a crucial role in the pathogenesis of AD. To elucidate the supramolecular structure of the A{beta}42 protofibrils, the intermolecular proximity of the Ala-21 residues in the A{beta}42 protofibrils was analyzed by {sup 13}C-{sup 13}C rotational resonance experiments in the solid state. Unlike the A{beta}42 fibrils, an intermolecular {sup 13}C-{sup 13}C correlation was not found in the A{beta}42 protofibrils. This result suggests that the {beta}-strands of the A{beta}42 protofibrils are not in an in-register parallel orientation. A{beta}42 monomers would assemble to form protofibrils with the {beta}-strand conformation, then transform into fibrils by forming intermolecular parallel {beta}-sheets.

  14. Method for treating beta-spodumene ceramics

    DOE Patents [OSTI]

    Day, J. Paul; Hickman, David L.

    1994-09-27

    A vapor-phase method for treating a beta-spodumene ceramic article to achieve a substitution of exchangeable hydrogen ions for the lithium present in the beta-spodumene crystals, wherein a barrier between the ceramic article and the source of exchangeable hydrogen ions is maintained in order to prevent lithium contamination of the hydrogen ion source and to generate highly recoverable lithium salts, is provided.

  15. Beta/alpha continuous air monitor

    DOE Patents [OSTI]

    Becker, Gregory K.; Martz, Dowell E.

    1989-01-01

    A single deep layer silicon detector in combination with a microcomputer, recording both alpha and beta activity and the energy of each pulse, distinguishing energy peaks using a novel curve fitting technique to reduce the natural alpha counts in the energy region where plutonium and other transuranic alpha emitters are present, and using a novel algorithm to strip out radon daughter contribution to actual beta counts.

  16. Beta/alpha continuous air monitor

    DOE Patents [OSTI]

    Becker, G.K.; Martz, D.E.

    1988-06-27

    A single deep layer silicon detector in combination with a microcomputer, recording both alpha and beta activity and the energy of each pulse, distinquishing energy peaks using a novel curve fitting technique to reduce the natural alpha counts in the energy region where plutonium and other transuranic alpha emitters are present, and using a novel algorithm to strip out radon daughter contribution to actual beta counts. 7 figs.

  17. Polypeptides having beta-glucosidase activity and polynucleotides encoding same

    SciTech Connect (OSTI)

    Morant, Marc Dominique

    2014-10-14

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  18. Quarterly Progress Report

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    737.000 1366 Project Silicon: Reclaiming US Silicon PV Leadership 1366 Technologies, Inc. Page 1 of 26 Final Report for DOE/EERE Project Title: 1366 Project Silicon: Reclaiming US Silicon PV Leadership Reporting Period: Apr 1, 2015 - Jun. 30, 2015 Approved Project Period: Sept. 1, 2012 to Sept 30, 2015 Submission Date: Jan 22, 2016 Recipient: 1366 Technologies 6 Preston Court Bedford, MA 01730 Website (if available) www.1366tech.com Award Number: DE-EE0005737.000 Working Partners: none

  19. REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DOE/NV/11718-387 ECOLOGICAL MONITORING AND COMPLIANCE PROGRAM FISCAL YEAR 1999 REPORT December 1999 Prepared by Ecological Services P.O. Box 98521 Las Vegas, NV 89193-8521 DISCLAIMER STATEMENT Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the U.S. Government or any agency thereof or its contractors or subcontractors.

  20. Reports

    Office of Legacy Management (LM)

    Reports . . . . , Book -1. Service Open File Information for Project Rulison, Production Testing Phase, . , August 28,1970 : . "; DISCLAIMER Portions of this document may be illegible in electronic image products. Images are produced from the best available original document. DESCRIPTION O F PU1:T41C I-l!lkI,T;-1 SE1:VICh: 0P:SN F I L E INPOPt4ATION i[ ' 7 S&u-~%uestcrn E a d i o l o g i c a l H e a l t h 1,aboratol-p r? U. S. Depaieraent o f I l e a l t h ,. E d u c a t i o n aud

  1. A ton-scale bolometric detector for the search for neutrinoless double beta decay

    SciTech Connect (OSTI)

    Pedretti, M. [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550 (United States)

    2009-12-16

    After an introduction on neutrinoless double beta decay physics, a description of CUORE and CUORICINO experiments, detectors and results are reported. The actual efforts and next steps of the CUORE Project, required to probe the inverted hierarchy region of the neutrino effective Majorana mass, are also described.

  2. Insider Alert 1.0 Beta Version

    Energy Science and Technology Software Center (OSTI)

    2004-02-01

    Insider Alert 1.0 Beta Version supports interactive selection and graphical display of data generated by the Sandia Cognitive Framework, which simulates the examination of security data by experts of various specialties. Insider Alert also encompasses the configuration and data files input to the Cognitive Framework for this application. Insider Alert 1.0 Beta Version is a computer program for analyzing data indicative of possible espionage or improper handling of data by employees at Sandia National Laboratoriesmore » (or other facilities with comparable policies and procedures for managing sensitive information) It prioritizes and displays information for review by security analysts.« less

  3. Method of producing .beta.-spodumene bodies

    DOE Patents [OSTI]

    Chyung, Kenneth; Day, J. Paul; Holleran, Louis M.; Olszewski, Anthony R.

    1999-01-01

    Beta-spodumene bodies and method of preparing the bodies that involves providing a uniform plastic batch of inorganic raw materials, organic binder, and vehicle, wherein the inorganic raw materials are composed of, in percent by weight, about 75% to 95% minerals, and about 5% to 25% glass. The batch is formed into a green body that is fired to produce a body composed substantially of beta-spodumene, and having a thermal expansion coefficient of <10.times.10.sup.-7 /.degree.C.(0-800.degree. C.), and a strength of .gtoreq.4 Ksi.

  4. The double-beta decay: Theoretical challenges

    SciTech Connect (OSTI)

    Horoi, Mihai

    2012-11-20

    Neutrinoless double beta decay is a unique process that could reveal physics beyond the Standard Model of particle physics namely, if observed, it would prove that neutrinos are Majorana particles. In addition, it could provide information regarding the neutrino masses and their hierarchy, provided that reliable nuclear matrix elements can be obtained. The two neutrino double beta decay is an associate process that is allowed by the Standard Model, and it was observed for about ten nuclei. The present contribution gives a brief review of the theoretical challenges associated with these two process, emphasizing the reliable calculation of the associated nuclear matrix elements.

  5. Ultrafast Dynamic Response of Single Crystal PETN and Beta-HMX (Conference)

    Office of Scientific and Technical Information (OSTI)

    | SciTech Connect Dynamic Response of Single Crystal PETN and Beta-HMX Citation Details In-Document Search Title: Ultrafast Dynamic Response of Single Crystal PETN and Beta-HMX Authors: Zaug, J M ; Armstrong, M R ; Crowhurst, J C ; Feranti, L ; Swan, R ; Gross, R ; Teshlich, N E ; Wall, M ; Austin, R A ; Fried, L E Publication Date: 2014-06-30 OSTI Identifier: 1149550 Report Number(s): LLNL-CONF-656341 DOE Contract Number: DE-AC52-07NA27344 Resource Type: Conference Resource Relation:

  6. {beta} decay spectroscopy of {sup 192}Pt and the nature of 0{sup +} excitations.

    SciTech Connect (OSTI)

    McCutchan, E. A.; Casten, R. F.; Werner, V.; Winkler, R.; Cakirli, R. B.; Gurdal, G.; Liang, X.; Williams, E.; Physics; Yale Univ.; Istanbul Univ.; Clark Univ.; Univ.of Paisley

    2008-07-01

    Excited states in {sup 192}Pt were populated in {beta}{sup +}/{epsilon} decay and studied through off-beam {gamma}-ray spectroscopy. New coincidence data give no support for several reported low-energy, low-spin states proposed in {beta} decay and lead to a substantially revised level scheme. The structure of {sup 192}Pt is discussed in terms of both single-space IBA-1 calculations and two-space IBA calculations with configuration mixing. Both models together suggest that it is the perhaps the 04{sup +} state that corresponds to an intruder excitation, resulting from the excitation of a pair of protons across the Z=82 closed shell.

  7. Effects of plasma {beta} on the plasmoid instability

    SciTech Connect (OSTI)

    Ni Lei; Ziegler, Udo; Huang Yimin; Lin Jun; Mei Zhixing

    2012-07-15

    The effects of the initial upstream plasma {beta} on the plasmoid instability are studied via two-dimensional resistive magnetohydrodynamic simulations. For cases with nonuniform {beta} dependent initial plasma mass density and uniform temperature, our numerical results indicate that the critical Lundquist number for onset of the plasmoid instability depends on the initial plasma {beta}. The critical Lundquist number is approximately 2000-3000 for {beta}=50 and is 8000-10 000 for {beta}=0.2. The higher the {beta}, the smaller the critical Lundquist number is. Similar to previous studies of high-{beta} systems, the average reconnection rate in low {beta} systems is found to become weakly dependent on the Lundquist number in the plasmoid-unstable regime. However, the average reconnection rate, normalized to the asymptotic value of upstream BV{sub A}, is lower in a low {beta} system than that in a high {beta} system. The magnetic energy spectral index, which characterizes fragmentation of the reconnection layer, is approximately two and is insensitive to {beta} in the high-Lunquist number regime. It is also found that the magnetic reconnection rate becomes similar for different {beta} cases, if the initial force-balance is provided by temperature gradient instead of density gradient. Therefore, it is concluded that the {beta}-dependence mentioned above may be largely attributed to the density variation.

  8. Tevatron low-beta quadrupole triplet interconnects

    SciTech Connect (OSTI)

    Oleck, A.R.; Carson, J.A.; Koepke, K.; Sorenson, D.

    1992-04-01

    Installation of cold iron quadrupole magnets in the Low Beta (Superconducting High-Luminosity) upgrade at Fermilab required a newly designed magnet interconnect. The interconnect design and construction experience is presented. Considered are the connections carrying cryogenic fluids, beam vacuum, insulating vacuum, superconducting bus leads, their insulation and mechanical support. Details of the assembly and assembly experience are presented. 2 refs.

  9. .beta.-glucosidase 5 (BGL5) compositions

    DOE Patents [OSTI]

    Dunn-Coleman, Nigel; Goedegebuur, Frits; Ward, Michael; Yao, Jian

    2010-06-01

    The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl5, and the corresponding BGL5 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL5, recombinant BGL5 proteins and methods for producing the same.

  10. Report of the Committee on antitrust

    SciTech Connect (OSTI)

    Not Available

    1994-01-01

    This report of the Committee on Antitrust summarizes certain energy industry cases brought under the federal antitrust laws (i.e., Sherman Act, Clayton Act, Robinson-Patman Act) for the prior three years. This report also summarizes several significant Supreme Court decisions concerning the antitrust laws during this period. These cases did not involve energy matters, but they may have a significant bearing on antitrust situations involving energy companies.

  11. Sensitivity of CUORE to Neutrinoless Double-Beta Decay (Journal...

    Office of Scientific and Technical Information (OSTI)

    Sensitivity of CUORE to Neutrinoless Double-Beta Decay Citation Details In-Document Search Title: Sensitivity of CUORE to Neutrinoless Double-Beta Decay In this paper, we study the...

  12. Sensitivity of CUORE to Neutrinoless Double-Beta Decay (Journal...

    Office of Scientific and Technical Information (OSTI)

    Sensitivity of CUORE to Neutrinoless Double-Beta Decay Citation Details In-Document Search Title: Sensitivity of CUORE to Neutrinoless Double-Beta Decay You are accessing a...

  13. Fact Sheet: Sodium-Beta Batteries (October 2012)

    Broader source: Energy.gov [DOE]

    DOE's Energy Storage Program is funding research to further develop a novel planar design for sodium-beta batteries (Na-beta batteries or NBBs) that will improve energy and power densities and...

  14. Nonaqueous actinide hydride dissolution and production of actinide $beta$- diketonates

    DOE Patents [OSTI]

    Crisler, L.R.

    1975-11-11

    Actinide beta-diketonate complex molecular compounds are produced by reacting a beta-diketone compound with a hydride of the actinide material in a mixture of carbon tetrachloride and methanol. (auth)

  15. He II Ly{beta} GUNN-PETERSON ABSORPTION: NEW HST OBSERVATIONS AND THEORETICAL EXPECTATIONS

    SciTech Connect (OSTI)

    Syphers, David; Pieri, Matthew; Shull, J. Michael; Anderson, Scott F.; Zheng, Wei; Kriss, Gerard A.; Smith, Britton; Meiksin, Avery; Schneider, Donald P.; York, Donald G.

    2011-12-01

    Observations of He II Ly{alpha} Gunn-Peterson troughs have proved to be a valuable probe of the epoch of helium reionization at z {approx} 3. Since this optical depth can become unmeasurably large even for modest He II fractions, various alternate techniques have been proposed to push to higher redshift, and among the more promising is looking at higher-order Lyman-series troughs. We here report four new observations of the He II Ly{beta} trough, including new data on the only sightline with a prior Ly{beta} observation. However, the effective optical depth ratio {tau}{sub eff,{beta}}/{tau}{sub eff,{alpha}} is not simply predicted by f{sub {beta}}{lambda}{sub {beta}}/f{sub {alpha}}{lambda}{sub {alpha}} = 0.16, and we analyze cosmological simulations to find that the correct ratio for helium at z {approx} 3 is {approx_equal}0.35. In one case we infer {tau}{sub eff,{alpha}} > 8.8, strong evidence that helium was not fully reionized at z = 3.2-3.5, in agreement with previous measurements suggesting a later completion of reionization.

  16. HIA 2015 DOE Zero Energy Ready Home Case Study: High Performance Homes, Chamberlain Court #75, Gettysburg, PA

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Performance Homes Chamberlain Court #75 Gettysburg, PA DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are

  17. Peroxisome proliferator-activated receptor {gamma} is expressed in hippocampal neurons and its activation prevents {beta}-amyloid neurodegeneration: role of Wnt signaling

    SciTech Connect (OSTI)

    Inestrosa, Nibaldo C. . E-mail: ninestr@genes.bio.puc.cl; Godoy, Juan A.; Quintanilla, Rodrigo A.; Koenig, Cecilia S.; Bronfman, Miguel

    2005-03-10

    The molecular pathogenesis of Alzheimer's disease (AD) involves the participation of the amyloid-{beta}-peptide (A{beta}), which plays a critical role in the neurodegeneration that triggers the disease. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, which are members of the nuclear receptor family. We report here that (1) PPAR{gamma} is present in rat hippocampal neurons in culture. (2) Activation of PPAR{gamma} by troglitazone and rosiglitazone protects rat hippocampal neurons against A{beta}-induced neurodegeneration, as shown by the 3-[4,5 -2yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay, immunofluorescence using an anti-heavy neurofilament antibody, and quantitative electron microscopy. (3) Hippocampal neurons treated with several PPAR{gamma} agonists, including troglitazone, rosiglitazone, and ciglitazone, prevent the excitotoxic A{beta}-induced rise in bulk-free Ca{sup 2+}. (4) PPAR{gamma} activation results in the modulation of Wnt signaling components, including the inhibition of glycogen synthase kinase-3{beta} (GSK-3{beta}) and an increase of the cytoplasmic and nuclear {beta}-catenin levels. We conclude that the activation of PPAR{gamma} prevents A{beta}-induced neurodegeneration by a mechanism that may involve a cross talk between neuronal PPAR{gamma} and the Wnt signaling pathway. More important, the fact that the activation of PPAR{gamma} attenuated A{beta}-dependent neurodegeneration opens the possibility to fight AD from a new therapeutic perspective.

  18. Y-12 Beta-3 Racetracks | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Y-12 Beta-3 Racetracks Y-12 Beta-3 Racetracks Y-12 Beta-3 Racetracks Built near the northeastern end of the Oak Ridge reservation, the Y-12 facility used the electromagnetic method to separate uranium-235 from the uranium-238 in natural uranium. During the Manhattan Project, Y-12 housed nine Alpha and eight Beta racetracks, which were arrangements of huge electromagnets containing a number of calutrons in the magnets' gaps. The calutrons sent a stream of charged particles through the magnetic

  19. Method for conversion of .beta.-hydroxy carbonyl compounds

    DOE Patents [OSTI]

    Lilga, Michael A. (Richland, WA); White, James F. (Richland, WA); Holladay, Johnathan E. (Kennewick, WA); Zacher, Alan H. (Kennewick, WA); Muzatko, Danielle S. (Kennewick, WA); Orth, Rick J. (Kennewick, WA)

    2010-03-30

    A process is disclosed for conversion of salts of .beta.-hydroxy carbonyl compounds forming useful conversion products including, e.g., .alpha.,.beta.-unsaturated carbonyl compounds and/or salts of .alpha.,.beta.-unsaturated carbonyl compounds. Conversion products find use, e.g., as feedstock and/or end-use chemicals.

  20. Neutrinoless double-{beta} decay: Status and future

    SciTech Connect (OSTI)

    Bilenky, S. M. [Joint Institute for Nuclear Research (Russian Federation)], E-mail: bilenky@he.sissa.it

    2006-12-15

    A brief summary of the status of neutrino masses, mixing, and oscillations is presented. Neutrinoless double {beta} decay is considered. Predictions for the effective Majorana mass are reviewed. A possible test of the calculations of nuclear matrix elements of the 0{nu}{beta}{beta} decay is proposed.

  1. Polypeptides having beta-glucosidase activity and polynucleotides encoding same

    SciTech Connect (OSTI)

    Morant, Marc

    2014-01-14

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase, or beta-glucosidase activity and isolated polynucleotides encoding polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  2. Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine [beta]-synthase

    SciTech Connect (OSTI)

    Koutmos, Markos; Kabil, Omer; Smith, Janet L.; Banerjee, Ruma

    2011-08-17

    The catalytic potential for H{sub 2}S biogenesis and homocysteine clearance converge at the active site of cystathionine {beta}-synthase (CBS), a pyridoxal phosphate-dependent enzyme. CBS catalyzes {beta}-replacement reactions of either serine or cysteine by homocysteine to give cystathionine and water or H{sub 2}S, respectively. In this study, high-resolution structures of the full-length enzyme from Drosophila in which a carbanion (1.70 {angstrom}) and an aminoacrylate intermediate (1.55 {angstrom}) have been captured are reported. Electrostatic stabilization of the zwitterionic carbanion intermediate is afforded by the close positioning of an active site lysine residue that is initially used for Schiff base formation in the internal aldimine and later as a general base. Additional stabilizing interactions between active site residues and the catalytic intermediates are observed. Furthermore, the structure of the regulatory 'energy-sensing' CBS domains, named after this protein, suggests a mechanism for allosteric activation by S-adenosylmethionine.

  3. The GERDA Neutrinoless Double Beta-Decay Experiment

    SciTech Connect (OSTI)

    Majorovits, Bela A. [Max Planck Institut fuer Physik, Foehringer Ring 6, 80805 Munich (Germany)

    2007-10-12

    Neutrinoless double beta (0{nu}{beta}{beta})-decay is the key process to gain understanding of the nature of neutrinos. The GErmanium Detector Array (GERDA) is designed to search for 0{nu}{beta}{beta}-decay of the isotope {sup 76}Ge. Germanium crystals enriched in {sup 76}Ge, acting as source and detector simultaneously, will be submerged directly into an ultra pure cooling medium that also serves as a radiation shield. This concept will allow for a reduction of the background by up to two orders of magnitudes with respect to earlier experiments.

  4. {beta} decay of {sup 26}Ne

    SciTech Connect (OSTI)

    Weissman, L.; Lisetskiy, A.F.; Arndt, O.; Dillmann, I.; Hallmann, O.; Kratz, K.L.; Pfeiffer, B.; Bergmann, U.; Cederkall, J.; Fraile, L.; Koester, U.; Franchoo, S.; Gaudefroy, L.; Sorlin, O.; Tabor, S.

    2004-11-01

    A pure neutron-rich {sup 26}Ne beam was obtained at the ISOLDE facility using isobaric selectivity. This was achieved by a combination of a plasma ion source with a cooled transfer line and subsequent mass separation. The high quality of the beam and good statistics allowed us to obtain new experimental information on the {sup 26}Ne {beta}-decay properties and resolve a contradiction between earlier experimental data and prediction of shell-model calculations.

  5. Crystal Structure of the alpha6beta6 Holoenzyme of propionyl-coenzyme A Carboxylase

    SciTech Connect (OSTI)

    Huang, C.; Sadre-Bazzaz, K; Shen, Y; Deng, B; Zhou, Z; Tong, L

    2010-01-01

    Propionyl-coenzyme A carboxylase (PCC), a mitochondrial biotin-dependent enzyme, is essential for the catabolism of the amino acids Thr, Val, Ile and Met, cholesterol and fatty acids with an odd number of carbon atoms. Deficiencies in PCC activity in humans are linked to the disease propionic acidaemia, an autosomal recessive disorder that can be fatal in infants. The holoenzyme of PCC is an {alpha}{sub 6}{beta}{sub 6} dodecamer, with a molecular mass of 750 kDa. The {alpha}-subunit contains the biotin carboxylase (BC) and biotin carboxyl carrier protein (BCCP) domains, whereas the {beta}-subunit supplies the carboxyltransferase (CT) activity. Here we report the crystal structure at 3.2-{angstrom} resolution of a bacterial PCC {alpha}{sub 6}{beta}{sub 6} holoenzyme as well as cryo-electron microscopy (cryo-EM) reconstruction at 15-{angstrom} resolution demonstrating a similar structure for human PCC. The structure defines the overall architecture of PCC and reveals unexpectedly that the {alpha}-subunits are arranged as monomers in the holoenzyme, decorating a central {beta}{sub 6} hexamer. A hitherto unrecognized domain in the {alpha}-subunit, formed by residues between the BC and BCCP domains, is crucial for interactions with the {beta}-subunit. We have named it the BT domain. The structure reveals for the first time the relative positions of the BC and CT active sites in the holoenzyme. They are separated by approximately 55 {angstrom}, indicating that the entire BCCP domain must translocate during catalysis. The BCCP domain is located in the active site of the {beta}-subunit in the current structure, providing insight for its involvement in the CT reaction. The structural information establishes a molecular basis for understanding the large collection of disease-causing mutations in PCC and is relevant for the holoenzymes of other biotin-dependent carboxylases, including 3-methylcrotonyl-CoA carboxylase (MCC) and eukaryotic acetyl-CoA carboxylase (ACC).

  6. Report of the Committee on Antitrust

    SciTech Connect (OSTI)

    Not Available

    1987-01-01

    The report covers antitrust cases involving fourteen natural gas and four oil companies and two electric utilities. There is a brief summary describing each suit and the court decision if one has been reached. Among the issues were whether a gas company can wholly own a pipeline subsidiary, pipeline power to refuse transport, mergers and acquisitions by stockholders, termination of service, oil futures, alleged price-fixing, and wholesale electric contracts.

  7. High-beta experiments with neutral-beam injection on PDX

    SciTech Connect (OSTI)

    Johnson, D.; Bell, M.; Bitter, M.

    1983-01-01

    We report experimental investigations of high-beta plasmas produced in PDX with near perpendicular neutral-beam injection. Systematic power scans have been performed over a wide range of toroidal fields (0.7T < B/sub T/ < 2.2T) and plasma currents (200 kA < I/sub p/ < 500 kA). At high toroidal fields, the change in total stored energy due to beam injection increases linearly with input power and also increases with plasma current. At lower toroidal fields and low injection-power levels, the stored energy also increases with power and plasma current. However, at high power and low toroidal fields, a saturation in heating is observed. This result suggests the onset of a ..beta../sub T/ limit for circular cross-sectional tokamaks with near-perpendicular injection. Scaling experiments indicate that this ..beta../sub T/ limit increases with rising (1/q). Values of ..beta../sub T/ approx. = 3% at q/sub Psi/ = 1.8 have been achieved.

  8. Human interleukin 2 receptor. beta. -chain gene: Chromosomal localization and identification of 5 prime regulatory sequences

    SciTech Connect (OSTI)

    Gnarra, J.R.; Otani, Hiroki; Wang, M.G.; McBride, O.W.; Sharon, M.; Leonard, W.J. )

    1990-05-01

    Interleukin 2 (IL-2) binds to and stimulates activated T cells through high-affinity IL-2 receptors (IL-2Rs). Such receptors represent a complex consisting of at least two proteins, the 55-kDa IL-2R{alpha} chain and the 70-kDa IL-2R{beta} chain. The low-affinity, IL-2R{alpha} chain cannot by itself transduce a mitogenic signal, whereas IL-2 stimulates resting lymphocytes through the intermediate-affinity, IL-2R{beta} receptor. The authors report here identification of the genomic locus for IL-2R{beta}. The exons are contained on four EcoRI fragments of 1.1, 9.2, 7.2, and 13.7 kilobases. The 1.1-kilobase EcoRI fragment lies at the 5{prime}-most end of the genomic locus and contains promoter sequences. The promoter contains no TATA box-like elements but does contain the d(GT){sub n} class of middle repetitive elements, which may play an interesting regulatory role. The IL-2R{beta} gene is localized to chromosome 22q11.2-q12, a region that is the locus for several lymphoid neoplasias.

  9. The BetaCage, an ultra-sensitive screener for surface contamination

    SciTech Connect (OSTI)

    Bunker, R.; Bowles, M. A.; Schnee, R. W.; Wang, B. [Department of Physics, Syracuse University, Syracuse, NY 13244 (United States)] [Department of Physics, Syracuse University, Syracuse, NY 13244 (United States); Ahmed, Z.; Golwala, S. R.; Nelson, R. H.; Rider, A.; Zahn, A. [California Institute of Technology, Pasadena, CA 91125 (United States)] [California Institute of Technology, Pasadena, CA 91125 (United States); Grant, D. R. [University of Alberta, Edmonton, AB, T6G 2R3 (Canada)] [University of Alberta, Edmonton, AB, T6G 2R3 (Canada); Kos, M. [Department of Physics, Syracuse University, Syracuse, NY 13244, USA and Pacific Northwest National Laboratory, Richland, WA 99352 (United States)] [Department of Physics, Syracuse University, Syracuse, NY 13244, USA and Pacific Northwest National Laboratory, Richland, WA 99352 (United States)

    2013-08-08

    Material screening for identifying low-energy electron emitters and alpha-decaying isotopes is now a prerequisite for rare-event searches (e.g., dark-matter direct detection and neutrinoless double-beta decay) for which surface radiocon-tamination has become an increasingly important background. The BetaCage, a gaseous neon time-projection chamber, is a proposed ultra-sensitive (and nondestructive) screener for alpha-and beta-emitting surface contaminants to which existing screening facilities are insufficiently sensitive. Sensitivity goals are 0.1 betas keV{sup ?1} m{sup ?2} day{sup ?1} and 0.1 alphas m{sup ?2} day{sup ?1}, with the former limited by Compton scattering of photons in the screening samples and (thanks to tracking) the latter expected to be signal-limited; radioassays and simulations indicate backgrounds from detector materials and radon daughters should be subdominant. We report on details of the background simulations and detector design that provide the discrimination, shielding, and radiopurity necessary to reach our sensitivity goals for a chamber with a 95 95 cm{sup 2} sample area positioned below a 40 cm drift region and monitored by crisscrossed anode and cathode planes consisting of 151 wires each.

  10. Chiral Two-body Currents and Neutrinoless Double Beta Decay

    SciTech Connect (OSTI)

    Menendez, Javier [Institut fuer Kernphysik, Technische Universitaet Darmstadt, 64289 Darmstadt (Germany); ExtreMe Matter Institute EMMI, GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, 64291 Darmstadt (Germany)

    2011-12-16

    The nuclear matrix elements (NMEs) of neutrinoless double-beta (0{nu}{beta}{beta}) decay are studied using weak currents derived in the framework of chiral effective field theory. Apart from the standard one-body (1b) currents, it is shown that two-body (2b) currents contribute to weak processes. The normal-ordered 1b part of 2b currents modifies the Gamow-Teller (GT){sigma}{tau}{sup -} part of the 1b current, contributing to the well-known quenching of GT single-{beta} decays. The momentum-transfer dependence of the quenching due to 2b currents is also predicted. Therefore, including 2b currents allows to address, microscopically, the problem of the axial weak coupling (g{sub A}) value, which is the biggest uncertainty in the 0{nu}{beta}{beta} decay NME calculations for all available methods.

  11. Preparation of reactive beta-dicalcium silicate

    DOE Patents [OSTI]

    Shen, M.S.; Chen, J.M.; Yang, R.T.

    1980-02-28

    This invention relates to the preparation of fine particles of reactive beta-dicalcium silicate by means of a solid state process which comprises firing a mixture of calcium sulfate, silica, and a reducing additive selected from the group consisting of calcium sulfide, carbon, carbon monoxide, methane, and hydrogen, at a temperature of about 850 to 1000/sup 0/C. A carrier gas such as nitrogen or carbon dioxide may also be added, if desired. A high concentration of sulfur dioxide is a by-product of this process.

  12. Preparation of reactive beta-dicalcium silicate

    DOE Patents [OSTI]

    Shen, Ming-Shing (Laramie, WY, NJ); Chen, James M. (Rahway, NJ); Yang, Ralph T. (Amherst, NY)

    1982-01-01

    This invention relates to the preparation of fine particles of reactive beta-dicalcium silicate by means of a solid state process which comprises firing a mixture of calcium sulfate, silica and a reducing additive selected from the group consisting of calcium sulfide, carbon, carbon monoxide, methane and hydrogen, at a temperature of about 850.degree.-1000.degree. C. A carrier gas such as nitrogen or carbon dioxide may also be added, if desired. A high concentration of sulfur dioxide is a by-product of this process.

  13. Method for preparing Pb-.beta."-alumina ceramic

    DOE Patents [OSTI]

    Hellstrom, Eric E.

    1986-01-01

    A process is disclosed for preparing impermeable, polycrystalline samples of Pb-.beta."-alumina ceramic from Na-.beta."-alumina ceramic by ion exchange. The process comprises two steps. The first step is a high-temperature vapor phase exchange of Na by K, followed by substitution of Pb for K by immersing the sample in a molten Pb salt bath. The result is a polycrystalline Pb-.beta."-alumina ceramic that is substantially crack-free.

  14. Proceedings of the Department of Energy workshop on beta measurements

    SciTech Connect (OSTI)

    Swinth, K.L.; Vallario, E.J.

    1987-09-01

    Participants discussed current practices, efforts to upgrade the quality of beta measurements, and initiatives necessary to improve the measurement and control of beta doses. This proceedings includes papers presented at the workshop, transcripts of panel and open discussions, and documentation of question and answer sessions. The information exchange resulting from this meeting is expected to provide a clearer focus on the problems of beta measurements.

  15. Labeled ALPHA4BETA2 ligands and methods therefor

    DOE Patents [OSTI]

    Mukherjee, Jogeshwar; Pichika, Ramaiah; Potkin, Steven; Leslie, Frances; Chattopadhyay, Sankha

    2013-02-19

    Contemplated compositions and methods are employed to bind in vitro and in vivo to an .alpha.4.beta.2 nicotinic acetylcholine receptor in a highly selective manner. Where such compounds are labeled, compositions and methods employing such compounds can be used for PET and SPECT analysis. Alternatively, and/or additionally contemplated compounds can be used as antagonists, partial agonists or agonists in the treatment of diseases or conditions associated with .alpha.4.beta..beta.2 dysfunction.

  16. National Library of Energy (BETA): the Department of Energy's National

    Office of Scientific and Technical Information (OSTI)

    Resource for Energy Literacy, Innovation and Security - Communications Communications NLEBeta Announcement NLEBeta Articles & Blogs OSTI.gov Newsletter July/August 2014: National Library of EnergyBeta: Cool Search Tool for Summer Search Tip: National Library of EnergyBeta New Search OSTIblog, May 29, 2014: Refreshed National Library of EnergyBeta Takes on Expanded Role in Disseminating Department of Energy Scientific and Technical Information OSTIblog, September 26, 2013: The National

  17. Neutrinoless double beta decay search with the NEMO 3 experiment

    SciTech Connect (OSTI)

    Nasteva, Irina [Particle Physics Group, School of Physics and Astronomy, University of Manchester, Manchester, M13 9PL (United Kingdom)

    2008-11-23

    The NEMO 3 experiment searches for neutrinoless double beta decay and makes precision measurements of two-neutrino double beta decay in seven isotopes. The latest two-neutrino half-life results are presented, together with the limits on neutrinoless half-lives and the corresponding effective Majorana neutrino masses. Also given are the limits obtained on neutrinoless double beta decay mediated by R{sub p}-violating SUSY, right-hand currents and different Majoron emission modes.

  18. In the OSTI Collections: Neutrinoless Double Beta Decay-Are Neutrinos and

    Office of Scientific and Technical Information (OSTI)

    Antineutrinos the Same? | OSTI, US Dept of Energy Office of Scientific and Technical Information Neutrinoless Double Beta Decay-Are Neutrinos and Antineutrinos the Same? Dr. Watson computer sleuthing scientist. Article Acknowledgement: Dr. William N. Watson, Physicist DOE Office of Scientific and Technical Information Observational Obstacles Experiments References Reports available from SciTech Connect and E-print Network Organizations and Laboratories Additional Reference Figure 1. The

  19. SNL-EFDC V0.0 BETA

    Energy Science and Technology Software Center (OSTI)

    002401WKSTN00 SNL-EFDC (Environmental Fluid Dynamics Code) v. 0.0 beta http://sourceforge.net/projects/snl-efdc/

  20. Neutron Beta Decay as a Probe of Weak Interactions (Conference...

    Office of Scientific and Technical Information (OSTI)

    Citation Details In-Document Search Title: Neutron Beta Decay as a Probe of Weak Interactions Authors: Saunders, Alexander 1 + Show Author Affiliations Los Alamos National ...

  1. Estrogen induced {beta}-1,4-galactosyltransferase 1 expression...

    Office of Scientific and Technical Information (OSTI)

    cancer MCF-7 cells Citation Details In-Document Search Title: Estrogen induced beta-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer ...

  2. Differential Impact of [beta] and [gamma] Residue Preorganization...

    Office of Scientific and Technical Information (OSTI)

    Differential Impact of beta and gamma Residue Preorganization on alphabetagamma-Peptide Helix Stability in Water Citation Details In-Document Search Title: Differential ...

  3. Low molecular weight thermostable .beta.-D-glucosidase from acidotherm...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Visual Patent Search Success Stories News Events Find More Like This Return to Search Low molecular weight thermostable .beta.-D-glucosidase from acidothermus cellulolyticus...

  4. Detection of alpha radiation in a beta radiation field

    DOE Patents [OSTI]

    Mohagheghi, Amir H.; Reese, Robert P.

    2001-01-01

    An apparatus and method for detecting alpha particles in the presence of high activities of beta particles utilizing an alpha spectrometer. The apparatus of the present invention utilizes a magnetic field applied around the sample in an alpha spectrometer to deflect the beta particles from the sample prior to reaching the detector, thus permitting detection of low concentrations of alpha particles. In the method of the invention, the strength of magnetic field required to adequately deflect the beta particles and permit alpha particle detection is given by an algorithm that controls the field strength as a function of sample beta energy and the distance of the sample to the detector.

  5. National Library of Energy (BETA): the Department of Energy's...

    Office of Scientific and Technical Information (OSTI)

    Communications NLEBeta Announcement NLEBeta Articles & Blogs OSTI.gov Newsletter JulyAugust 2014: National Library of EnergyBeta: Cool Search Tool for Summer Search Tip: National ...

  6. Exploring the Neutrinoless Double Beta Decay in the Inverted...

    Office of Scientific and Technical Information (OSTI)

    Neutrinoless double beta decay (0) is one of the most sensitive probes for physics beyond the Standard Model, providing unique information on the nature of neutrinos. In this ...

  7. Introducing The National Library of Energy (Beta), New Search...

    Office of Scientific and Technical Information (OSTI)

    The Department of Energy (DOE) Office of Scientific and Technical Information (OSTI) has launched the National Library of EnergyBeta (NLEBeta), a virtual library and open ...

  8. Neutron Interactions in the CUORE Neutrinoless Double Beta Decay...

    Office of Scientific and Technical Information (OSTI)

    Interactions in the CUORE Neutrinoless Double Beta Decay Experiment Dolinski, M J 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS; 73 NUCLEAR PHYSICS AND RADIATION PHYSICS;...

  9. What can we learn from neutrinoless double beta decay experiments...

    Office of Scientific and Technical Information (OSTI)

    What can we learn from neutrinoless double beta decay experiments? Citation Details ... Country of Publication: United States Language: English Subject: 72 nucleus, semileptonic ...

  10. Equilibrium pressure measurements in the beta region of palladium protide and palladium deuteride

    SciTech Connect (OSTI)

    Carstens, D.H.W.; David, W.R.

    1989-03-01

    We have measured the pressure-composition isotherms of the palladium-deuterium and palladium-protium systems in the beta region of both and the plateau region of the protide. For these two systems, data were measured at pressures up to about 3.5 MPa (500 psi) and at temperatures from 173 to 473 K. This study extends to a greater pressure and temperature regime the work on palladium hydrides reported previously by other authors. We also report results of an empirical analytical fit to the data for these two isotope systems. For completeness, we have applied our analysis to previously reported data for the tritide. The data were fit to an equation of the form P = exp/A + 2ln(R/(1 - R))-(B - CR)/T/ + exp(D + E/T), where R is the hydrogen-to-metal atomic ratio, P is the pressure, and T is the temperature. A, B, C, D, and E are empirically determined parameters and differ for absorbing and desorbing systems of each isotope. This equation gives a good fit to the data in the beta region of the absorption curves but a poorer fit in the alpha plus beta (plateau) region. 15 refs., 6 figs.

  11. The Promiscuity of [beta]-Strand Pairing Allows for Rational Design of [beta]-Sheet Face Inversion

    SciTech Connect (OSTI)

    Makabe, Koki; Koide, Shohei

    2009-06-17

    Recent studies suggest the dominant role of main-chain H-bond formation in specifying {beta}-sheet topology. Its essentially sequence-independent nature implies a large degree of freedom in designing {beta}-sheet-based nanomaterials. Here we show rational design of {beta}-sheet face inversions by incremental deletions of {beta}-strands from the single-layer {beta}-sheet of Borrelia outer surface protein A. We show that a {beta}-sheet structure can be maintained when a large number of native contacts are removed and that one can design large-scale conformational transitions of a {beta}-sheet such as face inversion by exploiting the promiscuity of strand-strand interactions. High-resolution X-ray crystal structures confirmed the success of the design and supported the importance of main-chain H-bonds in determining {beta}-sheet topology. This work suggests a simple but effective strategy for designing and controlling nanomaterials based on {beta}-rich peptide self-assemblies.

  12. Searches for massive neutrinos in nuclear beta decay

    SciTech Connect (OSTI)

    Jaros, J.A.

    1992-10-01

    The status of searches for massive neutrinos in nuclear beta decay is reviewed. The claim by an ITEP group that the electron antineutrino mass > 17eV has been disputed by all the subsequent experiments. Current measurements of the tritium beta spectrum limit m[sub [bar [nu

  13. Correlations and the neutrinoless double beta decay

    SciTech Connect (OSTI)

    Menendez, J.; Poves, A. [Departamento de Fisica Teorica, and IFT, UAM-CSIC, Universidad Autonoma de Madrid, 28049-Madrid (Spain); Caurier, E.; Nowacki, F. [IPHC, IN2P3-CNRS/Universite Louis Pasteur, 67037-Strasbourg (France)

    2009-11-09

    We explore the influence of the deformation on the nuclear matrix elements of the neutrinoless double beta decay (NME), concluding that the difference in deformation -or more generally on the amount of quadrupole correlations- between parent and grand daughter nuclei quenchs strongly the decay. We discuss how varies the nuclear matrix element of {sup 76}Ge decay when the wave functions of the two nuclei involved in the transition are constrained to reproduce the experimental occupancies. In the Interacting Shell Model description the value of the NME is enhanced about 15% compared to previous calculations, whereas in the QRPA the NME's are reduced by 20%-30%, thus, the discrepancies between both approaches diminish.

  14. Beta-endorphin and alpha-n-acetyl beta-endorphin; synthesis, conformation and binding parameter

    SciTech Connect (OSTI)

    Lovegren, E.S.

    1986-01-01

    Beta-endorphin (EP) is a 31-residue opioid peptide found in many tissues, including the pituitary, brain and reproductive tract. Alpha-amino-acetyl beta-endorphin (AcEP) was characterized spectroscopically by proton nuclear magnetic resonance (NMR) and circular dichroism in deuterated water and trifluoroethanol (TFE). Both EP and AcEP bind to neuroblastoma N2a cells. This binding was not mediated through opiate receptors, and both peptides seemed to bind at common sites. Ovarian immunoreactive-EP levels were determined for immature and mature rates. These levels were found to be responsive to exogenous gonadotropin treatment in immature animals. A large percentage of the immunoreactive-EP is present in follicular fluid, and most of the endorphin-like peptides were acetylated, as measured by radioimmunoassay. Chromatogaphic analysis suggested at least three EP-like species: EP, a carboxy-terminally cleaved and an amino-terminally acetylated EP.

  15. Constraining mass spectra with sterile neutrinos from neutrinoless double beta decay, tritium beta decay, and cosmology

    SciTech Connect (OSTI)

    Goswami, Srubabati [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211 019 (India); Physik-Department, Technische Universitaet Muenchen, James-Franck-Strasse, D-85748 Garching (Germany); Rodejohann, Werner [Physik-Department, Technische Universitaet Muenchen, James-Franck-Strasse, D-85748 Garching (Germany)

    2006-06-01

    We analyze the constraints on neutrino mass spectra with extra sterile neutrinos as implied by the LSND experiment. The various mass related observables in neutrinoless double beta decay, tritium beta decay and cosmology are discussed. Both neutrino oscillation results as well as recent cosmological neutrino mass bounds are taken into account. We find that some of the allowed mass patterns are severely restricted by the current constraints, in particular, by the cosmological constraints on the total sum of neutrino masses and by the nonmaximality of the solar neutrino mixing angle. Furthermore, we estimate the form of the four neutrino mass matrices and also comment on the situation in scenarios with two additional sterile neutrinos.

  16. Mutant HNF-1{alpha} and mutant HNF-1{beta} identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells

    SciTech Connect (OSTI)

    Gu Ning [Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto (Japan); Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto (Japan); Adachi, Tetsuya [Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto (Japan); Matsunaga, Tetsuro [Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto (Japan); Takeda, Jun [Department of Endocrinology Diabetes and Rheumatology, Graduate School of Medicine, Gifu University School of Medicine, Gifu (Japan); Tsujimoto, Gozoh [Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto (Japan); Ishihara, Akihiko [Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto (Japan); Yasuda, Koichiro [Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto (Japan); Diabetic Center, Tsunashimakai-Kosei Hospital, Himeji (Japan); Tsuda, Kinsuke [Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto (Japan)]. E-mail: jinkan@tom.life.h.kyoto-u.ac.jp

    2006-08-04

    Dipeptidylpeptidase IV (DPP-IV) is a well-documented drug target for the treatment of type 2 diabetes. Hepatocyte nuclear factors (HNF)-1{alpha} and HNF-1{beta}, known as the causal genes of MODY3 and MODY5, respectively, have been reported to be involved in regulation of DPP-IV gene expression. But, it is not completely clear (i) that they play roles in regulation of DPP-IV gene expression, and (ii) whether DPP-IV gene activity is changed by mutant HNF-1{alpha} and mutant HNF-1{beta} in MODY3 and MODY5. To explore these questions, we investigated transactivation effects of wild HNF-1{alpha} and 13 mutant HNF-1{alpha}, as well as wild HNF-1{beta} and 2 mutant HNF-1{beta}, on DPP-IV promoter luciferase gene in Caco-2 cells by means of a transient experiment. Both wild HNF-1{alpha} and wild HNF-1{beta} significantly transactivated DPP-IV promoter, but mutant HNF-1{alpha} and mutant HNF-1{beta} exhibited low transactivation activity. Moreover, to study whether mutant HNF-1{alpha} and mutant HNF-1{beta} change endogenous DPP-IV enzyme activity, we produced four stable cell lines from Caco-2 cells, in which wild HNF-1{alpha} or wild HNF-1{beta}, or else respective dominant-negative mutant HNF-1{alpha}T539fsdelC or dominant-negative mutant HNF-1{beta}R177X, was stably expressed. We found that DPP-IV gene expression and enzyme activity were significantly increased in wild HNF-1{alpha} cells and wild HNF-1{beta} cells, whereas they decreased in HNF-1{alpha}T539fsdelC cells and HNF-1{beta}R177X cells, compared with DPP-IV gene expression and enzyme activity in Caco-2 cells. These results suggest that both wild HNF-1{alpha} and wild HNF-1{beta} have a stimulatory effect on DPP-IV gene expression, but that mutant HNF-1{alpha} and mutant HNF-1{beta} attenuate the stimulatory effect.

  17. ON THE MISALIGNMENT OF THE DIRECTLY IMAGED PLANET {beta} PICTORIS b WITH THE SYSTEM'S WARPED INNER DISK

    SciTech Connect (OSTI)

    Dawson, Rebekah I.; Murray-Clay, Ruth A.; Fabrycky, Daniel C.

    2011-12-10

    The vertical warp in the debris disk {beta} Pictoris-an inclined inner disk extending into a flat outer disk-has long been interpreted as the signpost of a planet on an inclined orbit. Direct images spanning 2004-2010 have revealed {beta} Pictoris b, a planet with a mass and orbital distance consistent with this picture. However, it was recently reported that the orbit of planet b is aligned with the flat outer disk, not the inclined inner disk, and thus lacks the inclination to warp the disk. We explore three scenarios for reconciling the apparent misalignment of the directly imaged planet {beta} Pictoris b with the warped inner disk of {beta} Pictoris: observational uncertainty, an additional planet, and damping of planet b's inclination. We find that, at the extremes of the uncertainties, the orbit of {beta} Pictoris b has the inclination necessary to produce the observed warp. We also find that if planet b were aligned with the flat outer disk, it would prevent another planet from creating a warp with the observed properties; therefore planet b itself must be responsible for the warp. Finally, planet b's inclination could have been damped by dynamical friction and still produce the observed disk morphology, but the feasibility of damping depends on disk properties and the presence of other planets. More precise observations of the orbit of planet b and the position angle of the outer disk will allow us to distinguish between the first and third scenarios.

  18. {beta} decay spectroscopy of {sup 192}Pt and the nature of 0{sup +} excitations

    SciTech Connect (OSTI)

    McCutchan, E. A.; Casten, R. F.; Werner, V.; Winkler, R.; Williams, E.; Cakirli, R. B.; Guerdal, G.; Liang, X.

    2008-07-15

    Excited states in {sup 192}Pt were populated in {beta}{sup +}/{epsilon} decay and studied through off-beam {gamma}-ray spectroscopy. New coincidence data give no support for several reported low-energy, low-spin states proposed in {beta} decay and lead to a substantially revised level scheme. The structure of {sup 192}Pt is discussed in terms of both single-space IBA-1 calculations and two-space IBA calculations with configuration mixing. Both models together suggest that it is the perhaps the 0{sub 4}{sup +} state that corresponds to an intruder excitation, resulting from the excitation of a pair of protons across the Z=82 closed shell.

  19. A Beta-Particle Hodoscope Constructed Using Scintillating Optical Fibers and Position Sensitive Photomultiplier Tubes

    SciTech Connect (OSTI)

    Orrell, John L.; Aalseth, Craig E.; Day, Anthony R.; Fast, Jim; Hossbach, Todd W.; Lidey, Lance S.; Ripplinger, Mike D.; Schrom, Brian T.

    2006-09-19

    A hodoscopic detector was constructed using a position-sensitive plastic scintillator active area to determine the location of beta-active micron-sized particulates on air filters. The ability to locate beta active particulates on airsample filters is a tool for environmental monitoring of anthropogenic production of radioactive material. A robust, field-deployable instrument can provide localization of radioactive particulate with position resolution of a few millimeters. The detector employs a novel configuration of scintillating plastic elements usually employed at much higher charged particle energies. A filter is placed on this element for assay. The detector is intended to be sensitive to activity greater than 1 Bq. The physical design, position reconstruction method, and expected detector sensitivity are reported.

  20. Poster - DOE PAGES Beta | OSTI, US Dept of Energy, Office of...

    Office of Scientific and Technical Information (OSTI)

    PAGES Beta Document Files and References Available Downloads for this Document: applicationpdf icon Poster DOE PAGES Beta Last updated on Thursday 04 June

  1. Affinity and selectivity of beta-adrenoceptor antagonists in vitro

    SciTech Connect (OSTI)

    Wellstein, A.; Palm, D.; Belz, G.G.

    1986-01-01

    The potency order of the catecholamines (-)-isoprenaline (Iso), (-)-noradrenaline (NA), and (-)-adrenaline (Adr) in competition for radiolabelled sites is used for their pharmacological classification. It is shown that the radioligand /sup 3/H-CGP 12177 exclusively labels beta 1-adrenoceptors in rat salivary gland membranes (Iso greater than NA greater than Adr), and beta 2-adrenoceptors in rat reticulocytes (Iso greater than Adr greater than or equal to NA). These models are then used to derive the subtype-selectivity of the classical beta-adrenoceptor antagonists (+/-)-propranolol (prop; twofold beta 2-selective) and (+/-)-atenolol (aten; 35-fold beta 1-selective), as well as of the newer antagonists (+/-)-betaxolol and (+/-)-bisoprolol (betax and biso; 35-fold and 75-fold beta 1-selective, respectively). The ligand with the highest selectivity is ICI 118,551 (ICI), with a 300-fold beta 2-subtype selectivity. For comparison with antagonistic effects in humans at given plasma concentrations, the equilibrium dissociation constants of the ligands are measured in the presence of native human plasma and yield values for the relative selectively labelled subtype in the mean (Ki-values in nmol/l): prop: 20, aten: 250, biso: 24, betax: 23, and ICI: 2.5.

  2. Preliminary Test Results from 650 MHz Single Cell Medium Beta...

    Office of Scientific and Technical Information (OSTI)

    Preliminary Test Results from 650 MHz Single Cell Medium Beta Cavities for Project X Citation Details In-Document Search Title: Preliminary Test Results from 650 MHz Single Cell ...

  3. OSTIblog Articles in the neutrinos Neutrinoless Double Beta Decay...

    Office of Scientific and Technical Information (OSTI)

    Neutrinoless Double Beta Decay Topic Mining for Gold, Neutrinos and the Neutrinoless ... The site of the former Homestake Mine was once one of the largest and deepest gold mines ...

  4. Introducing The National Library of Energy (Beta), New Search...

    Office of Scientific and Technical Information (OSTI)

    Introducing The National Library of EnergyBeta, New Search Engine Facilitating Access to ... and developer tool" on the recently published new DOE resource hub for open energy data. ...

  5. Complementarity of Neutrinoless Double Beta Decay and Cosmology

    SciTech Connect (OSTI)

    Dodelson, Scott; Lykken, Joseph

    2014-03-20

    Neutrinoless double beta decay experiments constrain one combination of neutrino parameters, while cosmic surveys constrain another. This complementarity opens up an exciting range of possibilities. If neutrinos are Majorana particles, and the neutrino masses follow an inverted hierarchy, then the upcoming sets of both experiments will detect signals. The combined constraints will pin down not only the neutrino masses but also constrain one of the Majorana phases. If the hierarchy is normal, then a beta decay detection with the upcoming generation of experiments is unlikely, but cosmic surveys could constrain the sum of the masses to be relatively heavy, thereby producing a lower bound for the neutrinoless double beta decay rate, and therefore an argument for a next generation beta decay experiment. In this case as well, a combination of the phases will be constrained.

  6. Topics: Determining the Beta Limit - MST - UW Plasma Physics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Determining the Beta Limit UW Madison Madison Symmetric Torus Topics: Determining the Beta Limit MST HomeGraduate Student InformationLinksTourControl and Auxiliary SystemsPhysics TopicsDeviceResearch MissionMST People mst logo CPLA Home Directory Publications Links Internal University of Wisconsin Physics Department Research funding includes support from: Department of Energy National Science Foundation One of the reasons improved confinement in MST can be described as "tokamak-like"

  7. Introducing The National Library of Energy (Beta), New Search Engine

    Office of Scientific and Technical Information (OSTI)

    Facilitating Access to Department of Energy Information | OSTI, US Dept of Energy Office of Scientific and Technical Information February 15, 2013 Introducing The National Library of EnergyBeta, New Search Engine Facilitating Access to Department of Energy Information The Department of Energy (DOE) Office of Scientific and Technical Information (OSTI) has launched the National Library of EnergyBeta (NLEBeta), a virtual library and open government resource to advance energy literacy,

  8. No-neutrino double beta decay: more than one neutrino

    SciTech Connect (OSTI)

    Rosen, S.P.

    1983-01-01

    Interference effects between light and heavy Majorana neutrinos in the amplitude for no-neutrino double beta decay are discussed. The effects include an upper bound on the heavy neutrino mass, and an A dependence for the effective mass extracted from double beta decay. Thus the search for the no-neutrino decay mode should be pursued in several nuclei, and particularly in Ca/sup 48/, where the effective mass may be quite large.

  9. Effect of nuclear deformation on double beta decay

    SciTech Connect (OSTI)

    Rodin, Vadim [Institute fuer Theoretische Physik der Universitaet Tuebingen, D-72076 Tuebingen (Germany)

    2009-11-09

    The existing ways of accounting for deformation in recent calculations of neutrinoless double beta decay matrix elements are discussed. From an analysis of relevant experimental data it is argued that only {sup 150}Nd reveals convincing evidences of strong static deformation, which should eventually be taken into account in QRPA calculations. A proposal which allows in principle to measure the neutrino less double beta decay Fermi matrix element is briefly described.

  10. RELAP-7 Beta Release: Summary of Capabilities

    SciTech Connect (OSTI)

    Martineau, Richard C.; Zhang, Hongbin; Zhao, Haihua

    2014-12-01

    RELAP-7 is a nuclear systems safety analysis code being developed at the Idaho National Laboratory (INL). Building upon the decades of software development at the INL, we began the development of RELAP-7 in 2011 to support the Risk Informed Safety Margins Characterization (RISMC) Pathway. As part of this development, the first lines of RELAP-7 code were committed to the software revision control repository on November 7th, 2011. The overall design goal of RELAP-7 is to take advantage of the previous thirty years of advancements in computer architecture, software design, numerical methods, and physical models in order to provide capabilities needed for the RISMC methodology and to support nuclear power safety analysis. RELAP-7 is built using the INL’s modern scientific software development framework, MOOSE (Multi-physics Object Oriented Simulation Environment). MOOSE provides improved numerical calculations (including higher-order integration in both space and time, yielding converged second-order accuracy). The RELAP-7 code structure is based on multiple physical component models such as pipes, junctions, pumps, etc. Each component can have options for different fluid models such as single- and two-phase flow. This component-based and physics-based software architecture allows RELAP-7 to adopt different physical models for different applications. A relatively new two-phase hydrodynamic model, termed the ''7-Equation model'' for two phasic pressures, velocities, energies, and volumetric fraction, is incorporated into RELAP-7 for liquid-gas (water-steam) flows. This new model allows second-order integration because it is well-posed, which will reduce the numerical error associated with traditional systems analysis codes. In this paper, we provide a RELAP-7 capability list describing analysis features, range of applicability, and reactor components that will be available for the December 15th, 2014 beta release of the software.

  11. What can we learn from neutrinoless double beta decay experiments? (Journal

    Office of Scientific and Technical Information (OSTI)

    Article) | SciTech Connect What can we learn from neutrinoless double beta decay experiments? Citation Details In-Document Search Title: What can we learn from neutrinoless double beta decay experiments? We assess how well next generation neutrinoless double beta decay and normal neutrino beta decay experiments can answer four fundamental questions. 1) If neutrinoless double beta decay searches do not detect a signal, and if the spectrum is known to be inverted hierarchy, can we conclude

  12. Short-baseline electron neutrino disappearance, tritium beta decay, and neutrinoless double-beta decay

    SciTech Connect (OSTI)

    Giunti, Carlo; Laveder, Marco [INFN, Sezione di Torino, Via P. Giuria 1, I-10125 Torino (Italy); Dipartimento di Fisica G. Galilei, Universita di Padova, and INFN, Sezione di Padova, Via F. Marzolo 8, I-35131 Padova (Italy)

    2010-09-01

    We consider the interpretation of the MiniBooNE low-energy anomaly and the gallium radioactive source experiments anomaly in terms of short-baseline electron neutrino disappearance in the framework of 3+1 four-neutrino mixing schemes. The separate fits of MiniBooNE and gallium data are highly compatible, with close best-fit values of the effective oscillation parameters {Delta}m{sup 2} and sin{sup 2}2{theta}. The combined fit gives {Delta}m{sup 2}(greater-or-similar sign)0.1 eV{sup 2} and 0.11(less-or-similar sign)sin{sup 2}2{theta}(less-or-similar sign)0.48 at 2{sigma}. We consider also the data of the Bugey and Chooz reactor antineutrino oscillation experiments and the limits on the effective electron antineutrino mass in {beta} decay obtained in the Mainz and Troitsk tritium experiments. The fit of the data of these experiments limits the value of sin{sup 2}2{theta} below 0.10 at 2{sigma}. Considering the tension between the neutrino MiniBooNE and gallium data and the antineutrino reactor and tritium data as a statistical fluctuation, we perform a combined fit which gives {Delta}m{sup 2}{approx_equal}2 eV and 0.01(less-or-similar sign)sin{sup 2}2{theta}(less-or-similar sign)0.13 at 2{sigma}. Assuming a hierarchy of masses m{sub 1}, m{sub 2}, m{sub 3}<beta} decay and neutrinoless double-{beta} decay are, respectively, between about 0.06 and 0.49 and between about 0.003 and 0.07 eV at 2{sigma}. We also consider the possibility of reconciling the tension between the neutrino MiniBooNE and gallium data and the antineutrino reactor and tritium data with different mixings in the neutrino and antineutrino sectors. We find a 2.6{sigma} indication of a mixing angle asymmetry.

  13. Energy Density Functional Study of Nuclear Matrix Elements for Neutrinoless {beta}{beta} Decay

    SciTech Connect (OSTI)

    Rodriguez, Tomas R. [GSI Helmholtzzentrum fuer Schwerionenforschung, D-64259 Darmstadt (Germany); Departamento de Fisica Teorica, Universidad Autonoma de Madrid, E-28049 Madrid (Spain); CEA, Irfu, SPhN, Centre de Saclay, F-911191 Gif-sur-Yvette (France); Martinez-Pinedo, Gabriel [GSI Helmholtzzentrum fuer Schwerionenforschung, D-64259 Darmstadt (Germany)

    2010-12-17

    We present an extensive study of nuclear matrix elements (NME) for the neutrinoless double-beta decay of the nuclei {sup 48}Ca, {sup 76}Ge, {sup 82}Se, {sup 96}Zr, {sup 100}Mo, {sup 116}Cd, {sup 124}Sn, {sup 128}Te, {sup 130}Te, {sup 136}Xe, and {sup 150}Nd based on state-of-the-art energy density functional methods using the Gogny D1S functional. Beyond-mean-field effects are included within the generating coordinate method with particle number and angular momentum projection for both initial and final ground states. We obtain a rather constant value for the NMEs around 4.7 with the exception of {sup 48}Ca and {sup 150}Nd, where smaller values are found. We analyze the role of deformation and pairing in the evaluation of the NME and present detailed results for the decay of {sup 150}Nd.

  14. Shell model analysis of the neutrinoless double-{beta} decay of {sup 48}Ca

    SciTech Connect (OSTI)

    Horoi, Mihai [Department of Physics, Central Michigan University, Mount Pleasant, Michigan 48859 (United States); Stoica, Sabin [Horia Hulubei National Institute for Physics and Nuclear Engineering (IFIN-HH), 407 Atomistilor, Magurele-Bucharest, R-077125 (Romania)

    2010-02-15

    The neutrinoless double-{beta} (0{nu}{beta}{beta}) decay process could provide crucial information to determine the absolute scale of neutrino masses, and it is the only one that can establish whether a neutrino is a Dirac or a Majorana particle. A key ingredient for extracting the absolute neutrino masses from 0{nu}{beta}{beta} decay experiments is a precise knowledge of the nuclear matrix elements (NMEs) describing the half-life of this process. We developed a shell model approach for computing the 0{nu}{beta}{beta} decay NME, and we used it to analyze the 0{nu}{beta}{beta} mode of {sup 48}Ca. The dependence of the NME on the short-range correlation parameters, on the average energy of the intermediate states, on the finite-size cutoff parameters, and on the effective interaction used for many-body calculations is discussed.

  15. Resizing the conformal window: A {beta}-function ansatz

    SciTech Connect (OSTI)

    Antipin, O.; Tuominen, K.

    2010-04-01

    We propose an ansatz for the nonperturbative beta-function of a generic nonsupersymmetric Yang-Mills theory with or without fermions in an arbitrary representation of the gauge group. While our construction is similar to the recently proposed Ryttov-Sannino all-order beta-function, the essential difference is that it allows for the existence of an unstable ultraviolet fixed point in addition to the predicted Banks-Zaks-like infrared stable fixed point. Our beta-function preserves all of the tested features with respect to the nonsupersymmetric Yang-Mills theories. We predict the conformal window identifying the lower end of it as a merger of the infrared and ultraviolet fixed points.

  16. Reduction of beta* and increase of luminosity at RHIC

    SciTech Connect (OSTI)

    Pilat,F.; Bai, M.; Bruno, D.; Cameron, P.; Della Penna, A.; Drees, A.; Litvinenko, V.; Luo, Y.; Malitsky, N.; Marr, G.; Ptitsyn, V.; Satogata, T.; Tepikian, S.; Trbojevic, D.

    2009-05-04

    The reduction of {beta}* beyond the 1m design value at RHIC has been consistently achieved over the last 6 years of RHIC operations, resulting in an increase of luminosity for different running modes and species. During the recent 2007-08 deuteron-gold run the reduction to 0.70 from the design 1m achieved a 30% increase in delivered luminosity. The key ingredients allowing the reduction have been the capability of efficiently developing ramps with tune and coupling feedback, orbit corrections on the ramp, and collimation, to minimize beam losses in the final focus triplets, the main aperture limitations for the collision optics. We will describe the operational strategy used to reduce the {beta}*, at first squeezing the beam at store, to test feasibility, followed by the operationally preferred option of squeezing the beam during acceleration, and the resulting luminosity increase. We will conclude with future plans for the beta squeeze.

  17. Extra dimensions and neutrinoless double beta decay experiments

    SciTech Connect (OSTI)

    Gozdz, Marek; Kaminski, Wieslaw A.; Faessler, Amand [Theoretical Physics Department, Maria Curie-Sklodowska University, Lublin (Poland); Institute fuer Theoretische Physik, Universitaet Tuebingen, Auf der Morgenstelle 14, D-72076 Tuebingen (Germany)

    2005-05-01

    The neutrinoless double beta decay is one of the few phenomena, belonging to the nonstandard physics, which is extensively being sought for in experiments. In the present paper the link between the half-life of the neutrinoless double beta decay and theories with large extra dimensions is explored. The use of the sensitivities of currently planned 0{nu}2{beta} experiments: DAMA, CANDLES, COBRA, DCBA, CAMEO, GENIUS, GEM, MAJORANA, MOON, CUORE, EXO, and XMASS, gives the possibility for a nondirect 'experimental' verification of various extra dimensional scenarios. We discuss also the results of the Heidelberg-Moscow Collaboration. The calculations are based on the Majorana neutrino mass generation mechanism in the Arkani-Hamed-Dimopoulos-Dvali model.

  18. IL1{beta}-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells

    SciTech Connect (OSTI)

    Zhu, Yingting; Tissue Tech Inc, Miami, FL 33173 ; Zhu, Min; Lance, Peter

    2012-11-15

    COX-2 is a major inflammatory mediator implicated in colorectal inflammation and cancer. However, the exact origin and role of COX-2 on colorectal inflammation and carcinogenesis are still not well defined. Recently, we reported that COX-2 and iNOS signalings interact in colonic CCD18Co fibroblasts. In this article, we investigated whether activation of COX-2 signaling by IL1{beta} in primary colonic fibroblasts obtained from normal and cancer patients play a critical role in regulation of proliferation and invasiveness of human colonic epithelial cancer cells. Our results demonstrated that COX-2 level was significantly higher in cancer associated fibroblasts than that in normal fibroblasts with or without stimulation of IL-1{beta}, a powerful stimulator of COX-2. Using in vitro assays for estimating proliferative and invasive potential, we discovered that the proliferation and invasiveness of the epithelial cancer cells were much greater when the cells were co-cultured with cancer associated fibroblasts than with normal fibroblasts, with or without stimulation of IL1{beta}. Further analysis indicated that the major COX-2 product, prostaglandin E{sub 2}, directly enhanced proliferation and invasiveness of the epithelial cancer cells in the absence of fibroblasts. Moreover, a selective COX-2 inhibitor, NS-398, blocked the proliferative and invasive effect of both normal and cancer associate fibroblasts on the epithelial cancer cells, with or without stimulation of IL-1{beta}. Those results indicate that activation of COX-2 signaling in the fibroblasts plays a major role in promoting proliferation and invasiveness of the epithelial cancer cells. In this process, PKC is involved in the activation of COX-2 signaling induced by IL-1{beta} in the fibroblasts.

  19. Cold fusion: externally induced beta decay of the deuteron?

    SciTech Connect (OSTI)

    Driscoll, R.B.

    1995-04-01

    Plasma frequencies {nu}{sub e} of interstitial electrons in palladium crystals charged with deuterium by electrolysis can reach resonance with the beats of de Broglie group frequencies of deuterons. This frequency can occur during acoustic compressions of lattices due to (1) bubble formation at the Pd cathode, (2) particles from cosmic ray showers, and (3) beta decays of deuterons. Resonance perturbs the orbits of deuterons nucleon constituents with a finite probability of causing dissociation and beta decay -- that is the basic conjecture. The exponential tendency resulting from cause (3) of lattice compression is limited by melting of the lattice, whose integrity is essential for {nu}{sub e}, which drives the decays.

  20. A New Cavity Design For Medium Beta Acceleration

    SciTech Connect (OSTI)

    He, Feisi; Wang, Haipeng; Rimmer, Robert A.

    2014-02-01

    Heavy duty or cw, superconducting proton and heavy ion accelerators are being proposed and constructed worldwide. The total length of the machine is one of the main drivers in terms of cost. Thus hwr and spoke cavities at medium beta are usually optimized to achieve low surface field and high gradient. A novel accelerating structure at beta=0.5 evolved from spoke cavity is proposed, with lower surface fields but slightly higher heat load. It would be an interesting option for pulsed and cw accelerators with beam energy of more than 200mev/u.

  1. Selective oxidative synthesis of meso-beta fused porphyrin dimers

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Selective oxidative synthesis of meso-beta fused porphyrin dimers Authors: Brennan, B.J., Arero, J., Liddell, P.A., Moore, T.A., Moore, A.L., and Gust, D. Title: Selective oxidative synthesis of meso-beta fused porphyrin dimers Source: Journal of Porphyrins and Phthalocyanines Year: 2013 Volume: 17 Pages: 247-251 ABSTRACT: An efficient route to meso-β doubly connected fused porphyrin dimers was developed. Synthesis of the dimers incorporated two successive C-C bond-forming steps selectively

  2. Double-{beta} decay Q value of {sup 150}Nd

    SciTech Connect (OSTI)

    Kolhinen, V. S.; Eronen, T.; Gorelov, D.; Hakala, J.; Jokinen, A.; Kankainen, A.; Moore, I. D.; Rissanen, J.; Saastamoinen, A.; Suhonen, J.; Aeystoe, J. [Department of Physics, P. O. Box 35 (YFL), FI-40014 University of Jyvaeskylae (Finland)

    2010-08-15

    The double-{beta} decay Q value of {sup 150}Nd was determined by using the JYFLTRAP Penning trap mass spectrometer. The measured mass difference between {sup 150}Nd and {sup 150}Sm is 3371.38(20) keV. This new value deviates by 3.7 keV from the previously adopted value of 3367.7(22) keV and is a factor of 10 more precise. Accurate knowledge of this Q value is important because {sup 150}Nd is a primary candidate to be used in the search for neutrinoless double-{beta} decay modes in several experiments.

  3. Consistency test of neutrinoless double beta decay with one isotope

    SciTech Connect (OSTI)

    Duerr, Michael; Lindner, Manfred [Max-Planck-Institut fuer Kernphysik, Postfach 10 39 80, 69029 Heidelberg (Germany); Zuber, Kai [Technical University Dresden, Institut fuer Kern- und Teilchenphysik, 01069 Dresden (Germany)

    2011-11-01

    We discuss a consistency test which makes it possible to discriminate unknown nuclear background lines from neutrinoless double beta decay with only one isotope. By considering both the transition to the ground state and to the first excited 0{sup +} state, a sufficiently large detector can reveal if neutrinoless double beta decay or some other nuclear physics process is at work. Such a detector could therefore simultaneously provide a consistency test for a certain range of Majorana masses and be sensitive to lower values of the effective Majorana mass .

  4. Measurement of the p to s Wave Branching Ratio of {sup 187}Re {beta} Decay from Beta Environmental Fine Structure

    SciTech Connect (OSTI)

    Arnaboldi, C.; Brofferio, C.; Capelli, S.; Capozzi, F.; Cremonesi, O.; Fiorini, E.; Nucciotti, A.; Pavan, M.; Pessina, G.; Pirro, S.; Previtali, E.; Sisti, M.; Benedek, G.; Filipponi, A.; Giuliani, A.; Pedretti, M.; Monfardini, A.

    2006-02-03

    The mixed occurrence of s-wave and p-wave contributions in a first forbidden unique Gamow-Teller {beta} decay has been investigated for the first time by measuring the beta environmental fine structure (BEFS) in a {sup 187}Re crystalline compound. The experiment has been carried out with an array of eight AgReO{sub 4} thermal detectors operating at a temperature of {approx}100 mK. A fit of the observed BEFS spectrum indicates the p-wave electron emission as the dominant channel. The complete understanding of the BEFS distortion of the {sup 187}Re {beta} decay spectrum is crucial for future experiments aiming at the precise calorimetric measurement of the antineutrino mass.

  5. GERDA, a GERmanium Detector Array for the search for neutrinoless {beta}{beta} decay in 76Ge

    SciTech Connect (OSTI)

    Pandola, L.; Tomei, C. [INFN, Laboratori Nazionali del Gran Sasso, S.S. 17 bis km 18.910, 67010 Assergi (AQ) (Italy)

    2006-07-11

    The GERDA project, searching for neutrinoless double beta-decay of 76Ge with enriched germanium detectors submerged in a cryogenic bath, has been approved for installation at the Gran Sasso National Laboratory (LNGS), Italy. The GERDA technique is aiming at a dramatic reduction of the background due to radioactive contaminations of the materials surrounding the detectors. This will lead to a sensitivity of about 1026 years on the half-life of neutrinoless double beta decay. Already in the first phase of the experiment, GERDA will be able to investigate with high statistical significance the claimed evidence for neutrinoless double beta decay of 76Ge based on the data of the Heidelberg-Moscow experiment.

  6. The Majorana Double Beta Decay Experiment: Present Status

    SciTech Connect (OSTI)

    Aguayo, Estanislao; Avignone, Frank T.; Back, Henning O.; Barabash, Alexander S.; Beene, Jim; Bergevin, M.; Bertrand, F.; Boswell, M.; Brudanin, V.; Busch, Matthew; Chan, Yuen-Dat; Christofferson, C. D.; Collar, J. I.; Combs, Dustin C.; Cooper, R. J.; Detwiler, Jason A.; Doe, Peter J.; Efremenko, Yuri; Egorov, Viatcheslav; Ejiri, H.; Elliott, S. R.; Esterline, James H.; Fast, James E.; Fields, N.; Finnerty, P.; Fraenkle, Florian; Gehman, Victor M.; Giovanetti, G. K.; Green, M. P.; Guiseppe, V. E.; Gusey, K.; Hallin, A. L.; Hazama, R.; Henning, Reyco; Hime, Andrew; Hoppe, Eric W.; Horton, Mark; Howard, Stanley; Howe, M. A.; Johnson, R. A.; Keeter, K.; Keller, C.; Kidd, M. F.; Knecht, A.; Kochetov, Oleg; Konovalov, S.; Kouzes, Richard T.; Laferriere, Brian D.; LaRoque, B. H.; Leon, Jonathan D.; Leviner, L.; Loach, J. C.; MacMullin, S.; Marino, Michael G.; Martin, R. D.; Mei, Dong-Ming; Merriman, Jason H.; Miller, M. L.; Mizouni, Leila; Nomachi, Masaharu; Orrell, John L.; Overman, Nicole R.; Phillips II, D. G.; Poon, Alan; Perumpilly, Gopakumar; Prior, Gersende; Radford, D. C.; Rielage, Keith; Robertson, R. G. H.; Ronquest, M. C.; Schubert, Alexis G.; Shima, T.; Shirchenko, M.; Snavely, Kyle J.; Steele, David; Strain, J.; Thomas, K.; Timkin, V.; Tornow, W.; Vanyushin, I.; Varner, R. L.; Vetter, Kai; Vorren, Kris R.; Wilkerson, J. F.; Yakushev, E.; Young, A.; Yu, Chang-Hong; Yumatov, Vladimir; Zhang, C.

    2013-06-01

    The Majorana collaboration is actively pursuing research and development aimed at a tonne-scale 76Ge neutrinoless double-beta decay experiment, an R&D effort that will field approximately 40 kg of germanium detectors with mixed enrichment levels. This article provides a status update on the construction of the Demonstrator

  7. Polynucleotides encoding polypeptides having beta-glucosidase activity

    DOE Patents [OSTI]

    Harris, Paul; Golightly, Elizabeth

    2010-03-02

    The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

  8. Polypeptides having beta-glucosidase activity and polynucleotides encoding same

    DOE Patents [OSTI]

    Harris, Paul; Golightly, Elizabeth

    2011-06-14

    The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

  9. Polypeptides having beta-glucosidase activity and polynucleotides encoding same

    DOE Patents [OSTI]

    Harris, Paul; Golightly, Elizabeth

    2012-11-27

    The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

  10. Preparation of {alpha},{beta}-unsaturated carboxylic acids and esters

    DOE Patents [OSTI]

    Gogate, M.R.; Spivey, J.J.; Zoeller, J.R.

    1998-09-15

    Disclosed is a process for the preparation of {alpha},{beta}-unsaturated carboxylic acids and esters thereof which comprises contacting formaldehyde or a source of formaldehyde with a carboxylic acid, ester or anhydride in the presence of a catalyst comprising an oxide of niobium.

  11. Alpha-beta coordination method for collective search

    DOE Patents [OSTI]

    Goldsmith, Steven Y.

    2002-01-01

    The present invention comprises a decentralized coordination strategy called alpha-beta coordination. The alpha-beta coordination strategy is a family of collective search methods that allow teams of communicating agents to implicitly coordinate their search activities through a division of labor based on self-selected roles and self-determined status. An agent can play one of two complementary roles. An agent in the alpha role is motivated to improve its status by exploring new regions of the search space. An agent in the beta role is also motivated to improve its status, but is conservative and tends to remain aggregated with other agents until alpha agents have clearly identified and communicated better regions of the search space. An agent can select its role dynamically based on its current status value relative to the status values of neighboring team members. Status can be determined by a function of the agent's sensor readings, and can generally be a measurement of source intensity at the agent's current location. An agent's decision cycle can comprise three sequential decision rules: (1) selection of a current role based on the evaluation of the current status data, (2) selection of a specific subset of the current data, and (3) determination of the next heading using the selected data. Variations of the decision rules produce different versions of alpha and beta behaviors that lead to different collective behavior properties.

  12. Beam position monitor sensitivity for low-[beta] beams

    SciTech Connect (OSTI)

    Shafer, R.E. )

    1994-10-10

    Design of a beam position monitor (BPM) which is sensitive to low velo charged particle beams is considered. Quantitative estimates are made for the corrections to the conventional approximations to solutions of the Laplace Equation in two-dimensions when a BPM is used to measure to position of low velocity (low-[beta]) beams. (AIP)

  13. Preparation of {alpha}, {beta}-unsaturated carboxylic acids and anhydrides

    DOE Patents [OSTI]

    Spivey, J.J.; Gogate, M.R.; Zoeller, J.R.; Tustin, G.C.

    1998-01-20

    Disclosed is a process for the preparation of {alpha},{beta}-unsaturated carboxylic acids and anhydrides thereof which comprises contacting formaldehyde or a source of formaldehyde with a carboxylic anhydride in the presence of a catalyst comprising mixed oxides of vanadium, phosphorus and, optionally, a third component selected from titanium, aluminum or, preferably silicon.

  14. Preparation of .alpha.,.beta.-unsaturated carboxylic acids and esters

    DOE Patents [OSTI]

    Gogate, Makarand Ratnakar; Spivey, James Jerry; Zoeller, Joseph Robert

    1998-01-01

    Disclosed is a process for the preparation of .alpha.,.beta.-unsaturated carboxylic acids and esters thereof which comprises contacting formaldehyde or a source of formaldehyde with a carboxylic acid, ester or anhydride in the presence of a catalyst comprising an oxide of niobium.

  15. Preparation of .alpha., .beta.-unsaturated carboxylic acids and anhydrides

    DOE Patents [OSTI]

    Spivey, James Jerry; Gogate, Makarand Ratnakav; Zoeller, Joseph Robert; Tustin, Gerald Charles

    1998-01-01

    Disclosed is a process for the preparation of .alpha.,.beta.-unsaturated carboxylic acids and anhydrides thereof which comprises contacting formaldehyde or a source of formaldehyde with a carboxylic anhydride in the presence of a catalyst comprising mixed oxides of vanadium, phosphorus and, optionally, a third component selected from titanium, aluminum or, preferably silicon.

  16. Method for preparing 6-.beta.-halopenicillanic acids

    DOE Patents [OSTI]

    Hansen, Erik I.; Kran-Nielsen, Mogens P.; Von Daehne, Welf

    1989-01-01

    The present invention relates to a new and improved method for the preparation of a compound of the formula I ##STR1## in which R stands for halogen, giving rise to high yields of substantially pure 6.beta.-halopenicillanic acids, obtained in one step.

  17. Scaling factor inconsistencies in neutrinoless double beta decay

    SciTech Connect (OSTI)

    Cowell, S. [Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

    2006-02-15

    The modern theory of neutrinoless double beta decay includes a scaling factor that has often been treated inconsistently in the literature. The nuclear contribution to the decay half-life can be suppressed by 15%-20% when scaling factors are mismatched. Correspondingly, is overestimated.

  18. Majorana neutrino masses and the neutrinoless double-beta decay

    SciTech Connect (OSTI)

    Faessler, A. [University of Tuebingen, Institute of Theoretical Physics (Germany)], E-mail: amand.faessler@uni-tuebingen.de

    2006-12-15

    Neutrinoless double-beta decay is forbidden in the Standard Model of electroweak and strong interaction but allowed in most Grand Unified Theories (GUTs). Only if the neutrino is a Majorana particle (identical with its antiparticle) and if it has a mass is neutrinoless double-beta decay allowed. Apart from one claim that the neutrinoless double-beta decay in {sup 76}Ge is measured, one has only upper limits for this transition probability. But even the upper limits allow one to give upper limits for the electron Majorana neutrino mass and upper limits for parameters of GUTs and the minimal R-parity-violating supersymmetric model. One further can give lower limits for the vector boson mediating mainly the right-handed weak interaction and the heavy mainly right-handed Majorana neutrino in left-right symmetric GUTs. For that, one has to assume that the specific mechanism is the leading one for neutrinoless double-beta decay and one has to be able to calculate reliably the corresponding nuclear matrix elements. In the present work, one discusses the accuracy of the present status of calculating of the nuclear matrix elements and the corresponding limits of GUTs and supersymmetric parameters.

  19. Neutrinoless Double Beta Decay and {nu}-Mass Determination

    SciTech Connect (OSTI)

    Pedretti, M. [Universita dell Insubria, Via Vallegio 11, 22100 Como (Italy)

    2005-10-12

    The search for Neutrinoless Double Beta Decay could improve our knowledge on neutrino properties. After a brief discussion on the implications of the observation of this rare process, I will introduce the experimental approaches and review the prospects of the search for this nuclear transition.

  20. New Advances in Neutrinoless Double Beta Decay Matrix Elements

    SciTech Connect (OSTI)

    Munoz, Jose Barea [Instituto de Estructura de la Materia, C.S.I.C. Unidad Asociada al Departamento de Fisica Atomica, Molecular y Nuclear, Facultad de Fisica, Universidad de Sevilla, Apartado 1065, 41080 Sevilla (Spain)

    2010-08-04

    We present the matrix elements necessary to evaluate the half-life of some neutrinoless double beta decay candidates in the framework of the microscopic interacting boson model (IBM). We compare our results with those from other models and extract some simple features of the calculations.

  1. Neutrinoless double beta decay in the microscopic interacting boson model

    SciTech Connect (OSTI)

    Iachello, F. [Center for Theoretical Physics, Sloane Physics Laboratory Yale University New Haven, CT 06520-8120 (United States)

    2009-11-09

    The results of a calculation of the nuclear matrix elements for neutrinoless double beta decay in the closure approximation in several nuclei within the framework of the microscopic interacting boson model (IBM-2) are presented and compared with those calculated in the shell model (SM) and quasiparticle random phase approximation (QRPA)

  2. Conditions for detecting CP violation via neutrinoless double beta decay

    SciTech Connect (OSTI)

    Joniec, A.; Zralek, M. [Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice (Poland)

    2006-02-01

    Neutrinoless double beta decay data, together with information on the absolute neutrino masses obtained from the future KATRIN experiment and/or astrophysical measurements, provide a chance to find CP violation in the lepton sector with Majorana neutrinos. We derive and discuss necessary conditions which make discovery of such CP violation possible for the future neutrino oscillation and mass measurements data.

  3. Polypeptides having beta-glucosidase activity and polynucleotides encoding same

    SciTech Connect (OSTI)

    Harris, Paul; Golightly, Elizabeth

    2007-07-17

    The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

  4. Polypeptides having beta-glucosidase activity and polynucleotides encoding same

    DOE Patents [OSTI]

    Morant, Marc D; Patkar, Shamkant; Ding, Hanshu

    2013-11-12

    The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  5. Computer code for double beta decay QRPA based calculations

    SciTech Connect (OSTI)

    Barbero, C. A.; Mariano, A.; Krmpoti?, F.; Samana, A. R.; Ferreira, V. dos Santos; Bertulani, C. A.

    2014-11-11

    The computer code developed by our group some years ago for the evaluation of nuclear matrix elements, within the QRPA and PQRPA nuclear structure models, involved in neutrino-nucleus reactions, muon capture and ?{sup } processes, is extended to include also the nuclear double beta decay.

  6. BGL7 beta-glucosidase and nucleic acids encoding the same

    DOE Patents [OSTI]

    Dunn-Coleman, Nigel; Ward, Michael

    2012-03-13

    The present invention provides BGL7 polypeptides with the biological activity of a .beta.-glucosidase and a method of producing a recombinant enzyme having .beta.-glucosidase activity.

  7. Beta.-glucosidase coding sequences and protein from orpinomyces PC-2

    DOE Patents [OSTI]

    Li, Xin-Liang; Ljungdahl, Lars G.; Chen, Huizhong; Ximenes, Eduardo A.

    2001-02-06

    Provided is a novel .beta.-glucosidase from Orpinomyces sp. PC2, nucleotide sequences encoding the mature protein and the precursor protein, and methods for recombinant production of this .beta.-glucosidase.

  8. Double Beta Decay in Xenon-136: Measuring the Neutrino-Emitting...

    Office of Scientific and Technical Information (OSTI)

    Double Beta Decay in Xenon-136: Measuring the Neutrino-Emitting Mode and Searching for Majoron-Emitting Modes Citation Details In-Document Search Title: Double Beta Decay in...

  9. Ultrafast Dynamic Response of Single Crystal PETN and Beta-HMX...

    Office of Scientific and Technical Information (OSTI)

    Conference: Ultrafast Dynamic Response of Single Crystal PETN and Beta-HMX Citation Details In-Document Search Title: Ultrafast Dynamic Response of Single Crystal PETN and Beta-HMX...

  10. xLPR v2.0 beta 1 version status. (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    beta 1 version status. Citation Details In-Document Search Title: xLPR v2.0 beta 1 version status. Abstract not provided. Authors: Sallaberry, Cedric M. ; Dingreville, Remi ...

  11. Search for Neutrinoless Double-Beta Decay in 136Xe with EXO-200...

    Office of Scientific and Technical Information (OSTI)

    Neutrinoless Double-Beta Decay in 136Xe with EXO-200 Citation Details In-Document Search Title: Search for Neutrinoless Double-Beta Decay in 136Xe with EXO-200 Authors: Auger, M. ;...

  12. Cooperative Assembly of TGF-Beta Superfamily Signaling Complexes Is Mediated By Two Disparate Mechanisms And Distinct Modes of Receptor Binding

    SciTech Connect (OSTI)

    Groppe, J.; Hinck, C.S.; Samavarchi-Tehrani, P.; Zubieta, C.; Schuermann, J.P.; Taylor, A.B.; Schwarz, P.M.; Wrana, J.L.; Hinck, A.P.; /Texas U. /Mount Sinai Hospital, Toronto /SLAC, SSRL /Texas A-M

    2009-04-30

    Dimeric ligands of the transforming growth factor-beta (TGF-beta) superfamily signal across cell membranes in a distinctive manner by assembling heterotetrameric complexes of structurally related serine/threonine-kinase receptor pairs. Unlike complexes of the bone morphogenetic protein (BMP) branch that apparently form due to avidity from membrane localization, TGF-beta complexes assemble cooperatively through recruitment of the low-affinity (type I) receptor by the ligand-bound high-affinity (type II) pair. Here we report the crystal structure of TGF-beta3 in complex with the extracellular domains of both pairs of receptors, revealing that the type I docks and becomes tethered via unique extensions at a composite ligand-type II interface. Disrupting the receptor-receptor interactions conferred by these extensions abolishes assembly of the signaling complex and signal transduction (Smad activation). Although structurally similar, BMP and TGF-beta receptors bind in dramatically different modes, mediating graded and switch-like assembly mechanisms that may have coevolved with branch-specific groups of cytoplasmic effectors.

  13. Critical view to ''IGEX {sup 76}Ge neutrinoless double-beta decay experiment: Prospects for next generation experiments''

    SciTech Connect (OSTI)

    Klapdor-Kleingrothaus, H.V.; Dietz, A. [Max-Planck-Institut fuer Kernphysik, Postfach 10 39 80, D-69029 Heidelberg (Germany); Krivosheina, I. V. [Max-Planck-Institut fuer Kernphysik, Postfach 10 39 80, D-69029 Heidelberg (Germany); Radiophysical-Research Institute, Nishnii-Novgorod (Russian Federation)

    2004-10-01

    Recently, a paper entitled 'The IGEX {sup 76}Ge neutrinoless double-beta decay experiment: Prospects for next generation experiments' has been published [Phys. Rev. D 65, 092007 (2002)]. In view of the recently reported evidence for neutrinoless double-beta decay [Mod. Phys. Lett. A 16, 2409 (2001).; Found. Phys. 31, 1181 (2002); Phys. Lett. B 586, 198 (2004).], it is particularly unfortunate that the IGEX paper is rather incomplete in its presentation. We would like to point out in this Comment that and why it would be highly desirable to make more details about the experimental conditions and the analysis of IGEX available. We list some of the main points, which require further explanation. We also point to an arithmetic mistake in the analysis of the IGEX data, the consequence of which are too high half-life limits given in that paper.

  14. New precision measurements of free neutron beta decay with cold neutrons

    SciTech Connect (OSTI)

    Baeßler, Stefan; Bowman, James David; Penttilä, Seppo I.; Počanić, Dinko

    2014-10-14

    Precision measurements in free neutron beta decay serve to determine the coupling constants of beta decay, and offer several stringent tests of the standard model. This study describes the free neutron beta decay program planned for the Fundamental Physics Beamline at the Spallation Neutron Source at Oak Ridge National Laboratory, and finally puts it into the context of other recent and planned measurements of neutron beta decay observables.

  15. The Search for Neutrinoless Double Beta Decay with 130Te with CUORE-0

    SciTech Connect (OSTI)

    Jonathan Loren Ouellet

    2015-06-02

    This thesis describes the design, operation and results of an experimental search for neutrinoless double beta decay (0$\

  16. TGF-.beta. antagonists as mitigators of radiation-induced tissue damage

    DOE Patents [OSTI]

    Barcellos-Hoff, Mary H.

    1997-01-01

    A method for treating tissue damage caused by radiation is described by use of a TGF-.beta. antagonist, such as an anti-TGF-.beta. antibody or a TGF-.beta. latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.

  17. TGF-{beta} antagonists as mitigators of radiation-induced tissue damage

    DOE Patents [OSTI]

    Barcellos-Hoff, M.H.

    1997-04-01

    A method for treating tissue damage caused by radiation is described by use of a TGF-{beta} antagonist, such as an anti-TGF-{beta} antibody or a TGF-{beta} latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.

  18. Search for Neutrinoless Double-Beta Decay of Te130 with CUORE-0

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Alfonso, K.; Artusa, D. R.; Avignone, F. T.; Azzolini, O.; Balata, M.; Banks, T. I.; Bari, G.; Beeman, J. W.; Bellini, F.; Bersani, A.; et al

    2015-09-03

    We report the results of a search for neutrinoless double-beta decay in a 9.8 kg yr exposure of 130Te using a bolometric detector array, CUORE-0. The characteristic detector energy resolution and background level in the region of interest are 5:1± 0:3 keV FWHM and 0:058 ± 0:004 (stat) ± 0:002 (syst) counts / (keV kg yr), respectively. The median 90% C.L. lower-limit half-life sensitivity of the experiment is 2:9x1024 yr and surpasses the sensitivity of previous searches. We find no evidence for neutrinoless double-beta decay of 130Te and place a Bayesian lower bound on the decay half-life, T0ν1/2 > 2.7more » x 1024 yr at 90% C.L. Combining CUORE-0 data with the 19.75 kg yr exposure of 130Te from the Cuoricino experiment we obtain T0ν1/2 > 4.0 x 1024 yr at 90% C.L. (Bayesian), the most stringent limit to date on this half-life. Lastly, using a range of nuclear matrix element estimates we interpret this as a limit on the e ective Majorana neutrino mass, mββ < 270 -760 meV.« less

  19. Search for Neutrinoless Double-Beta Decay of with CUORE-0

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Alfonso, K.; Artusa, D.  R.; F. T. Avignone; Azzolini, O.; Balata, M.; Banks, T.  I.; Bari, G.; Beeman, J.  W.; Bellini, F.; Bersani, A.; et al

    2015-09-03

    We report the results of a search for neutrinoless double-beta decay in a 9.8 kg yr exposure of 130Te using a bolometric detector array, CUORE-0. The characteristic detector energy resolution and background level in the region of interest are 5.1 ± 0.3 keV FWHM and 0.058 ± 0.004 (stat.) ± 0:002 (syst.) counts/(keV kg yr), respectively. The median 90% C.L. lower-limit sensitivity of the experiment is 2.9 x 1024 yr and surpasses the sensitivity of previous searches. We find no evidence for neutrinoless double-beta decay of 130Te and place a Bayesian lower bound on the decay half-life, T0$_1$1/2 > 2.7more » x 1024 yr at 90% C.L. Combining CUORE-0 data with the 19.75 kg yr exposure of 130Te from the Cuoricino experiment we obtain T0$_1$1/2 > 4.0 x 1024 yr at 90% C.L. (Bayesian), the most stringent limit to date on this half-life. Using a range of nuclear matrix element estimates we interpret this as a limit on the effective Majorana neutrino mass, mββ < 270 - 760 meV.« less

  20. Measurement of the CP-Violating Phase beta_s in B0s -> J/Psi Phi Decays with the CDF II Detector

    SciTech Connect (OSTI)

    Aaltonen, T.; et al.

    2012-04-01

    We present a measurement of the \\CP-violating parameter \\betas using approximately 6500 $\\BsJpsiPhi$ decays reconstructed with the CDF\\,II detector in a sample of $p\\bar p$ collisions at $\\sqrt{s}=1.96$ TeV corresponding to 5.2 fb$^{-1}$ integrated luminosity produced by the Tevatron Collider at Fermilab. We find the \\CP-violating phase to be within the range $\\betas \\in [0.02, 0.52] \\cup [1.08, 1.55]$ at 68% confidence level where the coverage property of the quoted interval is guaranteed using a frequentist statistical analysis. This result is in agreement with the standard model expectation at the level of about one Gaussian standard deviation. We consider the inclusion of a potential $S$-wave contribution to the $\\Bs\\to J/\\psi K^+K^-$ final state which is found to be negligible over the mass interval $1.009 < m(K^+K^-)<1.028 \\gevcc$. Assuming the standard model prediction for the \\CP-violating phase \\betas, we find the \\Bs decay width difference to be $\\deltaG = 0.075 \\pm 0.035\\,\\textrm{(stat)} \\pm 0.006\\,\\textrm{(syst)} \\ps$. We also present the most precise measurements of the \\Bs mean lifetime $\\tau(\\Bs) = 1.529 \\pm 0.025\\,\\textrm{(stat)} \\pm 0.012\\,\\textrm{(syst)}$ ps, the polarization fractions $|A_0(0)|^2 = 0.524 \\pm 0.013\\,\\textrm{(stat)} \\pm 0.015\\,\\textrm{(syst)}$ and $|A_{\\parallel}(0)|^2 = 0.231 \\pm 0.014\\,\\textrm{(stat)} \\pm 0.015\\,\\textrm{(syst)}$, as well as the strong phase $\\delta_{\\perp}= 2.95 \\pm 0.64\\,\\textrm{(stat)} \\pm 0.07\\,\\textrm{(syst)} \\textrm{rad}$. In addition, we report an alternative Bayesian analysis that gives results consistent with the frequentist approach.

  1. Protonation of acyllithium reagents by acetonitrile: Synthesis of {beta}-hydroxy nitriles

    SciTech Connect (OSTI)

    Li, Nan-Sheng; Yu, Su; Kabalka, G.W. [Univ. of Tennessee, Knoxville, TN (United States)

    1995-09-08

    In recent years, the reaction of electrophiles with acyllithium (RCOLi) reagents has been extensively studied and has proven to be a convenient route to acylated products. For example, Seyferth reported that acyllithium reagents, generated in situ from an alkyllithium and carbon monoxide at -110 {degrees}C to -135 {degrees}C, would react with aldehydes, ketones, esters, lactones, isocyanates, isothiocyanates, carbodiimides, carbon disulfide, carbonyl sulfide, organic disulfides, iron pentacarbonyl, and trimethylchlorosilane to give acylated products. Nudelman found that the acyllithium generated from phenyllithium in the presence of alkyl bromides gave diphenylalkylcarbinols. The authors recently reported that trialkylboranes reacted with acyllithium reagents to afford ketones in modest yields. Although Seyferth predicted that acyl anion reagents might react with nitriles to afford addition products such as {alpha}-diketones, no report of a reaction of acyl anion reagents with nitriles has appeared in literature. Recently, the authors reported the first example of the protonation of acyllithium reagents by dichloromethane and dichloroarylmethane. The reaction affords the corresponding {alpha}, {alpha}-dichloro alcohols in excellent yields. The authors wish to report a new synthesis of {beta}-hydroxy nitriles which is based on the reaction of acyllithium with acetonitrile, Scheme 1. 1 tab.

  2. High beta plasma operation in a toroidal plasma producing device

    DOE Patents [OSTI]

    Clarke, John F.

    1978-01-01

    A high beta plasma is produced in a plasma producing device of toroidal configuration by ohmic heating and auxiliary heating. The plasma pressure is continuously monitored and used in a control system to program the current in the poloidal field windings. Throughout the heating process, magnetic flux is conserved inside the plasma and the distortion of the flux surfaces drives a current in the plasma. As a consequence, the total current increases and the poloidal field windings are driven with an equal and opposing increasing current. The spatial distribution of the current in the poloidal field windings is determined by the plasma pressure. Plasma equilibrium is maintained thereby, and high temperature, high beta operation results.

  3. Modular low aspect ratio-high beta torsatron

    DOE Patents [OSTI]

    Sheffield, George V.; Furth, Harold P.

    1984-02-07

    A fusion reactor device in which the toroidal magnetic field and at least a portion of the poloidal magnetic field are provided by a single set of modular coils. The coils are arranged on the surface of a low aspect ratio toroid in planes having the cylindrical coordinate relationship .phi.=.phi..sub.i +kz where k is a constant equal to each coil's pitch and .phi..sub.i is the toroidal angle at which the i'th coil intersects the z=o plane. The device may be described as a modular, high beta torsation whose screw symmetry is pointed along the systems major (z) axis. The toroid defined by the modular coils preferably has a racetrack minor cross section. When vertical field coils and preferably a toroidal plasma current are provided for magnetic field surface closure within the toroid, a vacuum magnetic field of racetrack shaped minor cross section with improved stability and beta valves is obtained.

  4. The Beta Environmental Fine Structure (BEFS): The XAFS Nuclear Analogue

    SciTech Connect (OSTI)

    Monfardini, A.; Benedek, G.; Cremonesi, O.; Nucciotti, A.; Sisti, M.; Filipponi, A.

    2007-02-02

    The Beta Environmental Fine Structure (BEFS) effect is an oscillatory modulation on the otherwise smooth spectrum of electrons emitted by beta-decaying nuclei. The existence of this effect was theoretically proposed in 1991, for condensed emitters, in analogy with XAFS. In BEFS the electron, playing the role of the XAFS photoelectron, originates directly from the nucleus and an anti-neutrino is emitted at the same time. We present evidence for BEFS oscillations observed in Silver Perrhenate (AgReO4) low-temperature (0.1K) microbolometers, together with a XAFS-like analysis that allowed for the first time a direct measurement of the anti-neutrino angular momentum. We discuss the physical analogies and differences between BEFS and XAFS and the implications for the next generation experiments aimed at measuring the neutrino mass on purely kinematic grounds. Moreover, we briefly discuss the potential and the limits of BEFS-based techniques with respect to the classical XAFS.

  5. Double beta decay, Majorana neutrinos, and neutrino mass

    SciTech Connect (OSTI)

    Avignone, Frank T. III; Elliott, Steven R.; Engel, Jonathan [Department of Physics and Astronomy, University of South Carolina, Columbia, South Carolina 29208 (United States); Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599-3255 (United States)

    2008-04-15

    The theoretical and experimental issues relevant to neutrinoless double beta decay are reviewed. The impact that a direct observation of this exotic process would have on elementary particle physics, nuclear physics, astrophysics, and cosmology is profound. Now that neutrinos are known to have mass and experiments are becoming more sensitive, even the nonobservation of neutrinoless double beta decay will be useful. If the process is actually observed, we will immediately learn much about the neutrino. The status and discovery potential of proposed experiments are reviewed in this context, with significant emphasis on proposals favored by recent panel reviews. The importance of and challenges in the calculation of nuclear matrix elements that govern the decay are considered in detail. The increasing sensitivity of experiments and improvements in nuclear theory make the future exciting for this field at the interface of nuclear and particle physics.

  6. Neutrinoless double {beta}-decay and neutrino mass hierarchies

    SciTech Connect (OSTI)

    Bilenky, S. M. [Scuola Internazionale Superiore di Studi Avanzati, I-34014 Trieste (Italy); Faessler, Amand; Gutsche, Thomas; Simkovic, Fedor [Institute fuer Theoretische Physik der Universitaet Tuebingen, D-72076 Tuebingen (Germany)

    2005-09-01

    In the framework of the seesaw mechanism the normal hierarchy is favorable for the neutrino mass spectrum. For this spectrum we present a detailed calculation of the half-lives of neutrinoless double {beta}-decay for several nuclei of experimental interest. The half-lives are evaluated by considering the most comprehensive nuclear matrix elements, which were obtained within the renormalized quasiparticle random phase approximation by the Bratislava-Caltech-Tuebingen group. The dependence of the half-lives on sin{sup 2}{theta}{sub 13} and the lightest neutrino mass is studied. We present also the results of the calculations of the half-lives of neutrinoless double {beta}-decay in the case of the inverted hierarchy of neutrino masses.

  7. Results of the double beta decay experiment NEMO-3

    SciTech Connect (OSTI)

    Tretyak, V. I. [Joint Institute for Nuclear Research, 6 Joliot Curie, Dubna (Russian Federation); Collaboration: NEMO-3 Collaboration

    2013-12-30

    The double beta decay experiment NEMO-3 has taken data from February 2003 to January 2011. The two-neutrino decay half lives were measured for seven different isotopes ({sup 100}Mo, {sup 82}Se, {sup 116}Cd, {sup 150}Nd, {sup 96}Zr, {sup 48}Ca and {sup 130}Te). No evidence for neutrinoless double beta decay is observed. The 0??? half-life limits are found to be T{sub 1/2}{sup 0?}({sup 100}Mo)>1.010{sup 24}yr(90%C.L.) and T{sub 1/2}{sup 0?}({sup 82}Se)>3.210{sup 23}yr(90%C.L.)

  8. First Results of the Search for Neutrinoless Double-Beta Decay with the NEMO 3 Detector

    SciTech Connect (OSTI)

    Arnold, R.; Caurier, E.; Guyonnet, J.L.; Jollet, C.; Nowacki, F. [IReS, IN2P3-CNRS and ULP, 67037 Strasbourg (France); Augier, C.; Errahmane, K.; Etienvre, A.I.; Jullian, S.; Lalanne, D.; Sarazin, X.; Simard, L.; Szklarz, G. [LAL, IN2P3-CNRS and UPS, 91405 Orsay (France); Baker, J.; Caffrey, A.J. [INL, Idaho Falls, Idaho 83415 (United States); Barabash, A.; Konovalov, S.; Umatov, V.; Vanushin, I.; Vasilyev, V. [ITEP, 117259 Moscow (Russian Federation)] [and others

    2005-10-28

    The NEMO 3 detector, which has been operating in the Frejus underground laboratory since February 2003, is devoted to the search for neutrinoless double-beta decay ({beta}{beta}0{nu}). The half-lives of the two neutrino double-beta decay ({beta}{beta}2{nu}) have been measured for {sup 100}Mo and {sup 82}Se. After 389 effective days of data collection from February 2003 until September 2004 (phase I), no evidence for neutrinoless double-beta decay was found from {approx}7 kg of {sup 100}Mo and {approx}1 kg of {sup 82}Se. The corresponding limits are T{sub 1/2}({beta}{beta}0{nu})>4.6x10{sup 23} yr for {sup 100}Mo and T{sub 1/2}({beta}{beta}0{nu})>1.0x10{sup 23} yr for {sup 82}Se (90% C.L.). Depending on the nuclear matrix element calculation, the limits for the effective Majorana neutrino mass are <0.7-2.8 eV for {sup 100}Mo and <1.7-4.9 eV for {sup 82}Se.

  9. Diversity of [beta]-globin mutations in Israeli ethnic groups reflects recent historic events

    SciTech Connect (OSTI)

    Filon, D.; Oron, V.; Krichevski, S.; Shaag, A.; Goldfarb, A.; Aker, M.; Rachmilewitz, E.A.; Rund, D.; Oppenheim, A. )

    1994-05-01

    The authors characterized nearly 500 [beta]-thalassemia genes from the Israeli population representing a variety of ethnic subgroups. They found 28 different mutations in the [beta]-globin gene, including three mutations ([beta][sup S], [beta][sup C], and [beta][sup O-Arab]) causing hemoglobinopathies. Marked genetic heterogeneity was observed in both the Arab (20 mutations) and Jewish (17 mutations) populations. On the other hand, two ethnic isolates - Druze and Samaritans - had a single mutation each. Fifteen of the [beta]-thalassemia alleles are Mediterranean in type, 5 originated in Kurdistan, 2 are of Indian origin, and 2 sporadic alleles came from Europe. Only one mutant allele-nonsense codon 37-appears to be indigenous to Israel. While human habitation in Israel dates back to early prehistory, the present-day spectrum of [beta]-globin mutations can be largely explained by migration events that occurred in the past millennium. 26 refs., 2 figs., 3 tabs.

  10. Challenges for a reliable shell model description of the neutrinoless double beta decay matrix elements

    SciTech Connect (OSTI)

    Horoi, Mihai [Department of Physics, Central Michigan University, Mount Pleasant, Michigan, 48859 (United States)

    2011-12-16

    Assuming that the neutrinos are Majorana particles and the neutrinoless double beta (0{nu}{beta}{beta}) decay is observed, a reliable 0{nu}{beta}{beta} matrix element is necessary to decide the neutrino mass hierarchy and the minimum neutrino mass. Many nuclear structure techniques, including the shell model, are presently used to calculate these matrix elements. In the last few years one could see a slow convergence of these results, but not yet at a level of 20 several shell model effective interactions and varying other parameters, finding results in a range that spans about 20In this contribution we describe challenges for obtaining reliable shell model 0{nu}{beta}{beta} matrix elements, with emphasis to {sup 76}Ge and {sup 82}Se decays.

  11. Weakly Turbulent Magnetohydrodynamic Waves in Compressible Low-{beta} Plasmas

    SciTech Connect (OSTI)

    Chandran, Benjamin D. G.

    2008-12-05

    In this Letter, weak-turbulence theory is used to investigate interactions among Alfven waves and fast and slow magnetosonic waves in collisionless low-{beta} plasmas. The wave kinetic equations are derived from the equations of magnetohydrodynamics, and extra terms are then added to model collisionless damping. These equations are used to provide a quantitative description of a variety of nonlinear processes, including parallel and perpendicular energy cascade, energy transfer between wave types, 'phase mixing', and the generation of backscattered Alfven waves.

  12. National Library of Energy (Beta): the Department of Energy's National

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Resource for Energy Literacy, Innovation and Security - FAQ Frequently Asked Questions What is the National Library of EnergyBeta (NLEBeta)? Why was the NLEBeta created? What does the NLEBeta search? What DOE program offices and national laboratories are included in the NLEBeta? Does the NLEBeta include any classified information? Does the NLEBeta host, edit, or revise any of the content on the NLEBeta? How is the NLEBeta search related to the DOE Energy.gov search? How often will the

  13. Low-temperature Sodium-Beta Battery - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Storage Energy Storage Find More Like This Return to Search Low-temperature Sodium-Beta Battery Lawrence Livermore National Laboratory Contact LLNL About This Technology Technology Marketing Summary Rechargeable metallic sodium batteries have application in large-scale energy storage applications such as electric power generation and distribution, in motive applications such as electric vehicles, hybrids, and plug-in hybrids, and for aerospace applications such as powering satellites. So

  14. Office of Scientific and Technical Information DOE PAGES (Beta) Portal

    Office of Scientific and Technical Information (OSTI)

    Offers Public Access to Scholarly Scientific Publications Resulting from DOE Research Funding | OSTI, US Dept of Energy Office of Scientific and Technical Information Office of Scientific and Technical Information DOE PAGES (Beta) Portal Offers Public Access to Scholarly Scientific Publications Resulting from DOE Research Funding Get a printer-friendly version Recent Presentations Office of Scientific and Technical Information DOE PAGESBeta Portal Offers Public Access to Scholarly Scientific

  15. National Library of Energy (BETA): the Department of Energy's National

    Office of Scientific and Technical Information (OSTI)

    Resource for Energy Literacy, Innovation and Security - About NLE About The Department of Energy (DOE) National Library of EnergyBeta (NLEBeta) is a national resource to advance energy literacy, innovation and security. The NLEBeta is a new search tool designed to make it easier for American citizens to find and access information from across the DOE complex nationwide, without knowing DOE's organizational structure. Such information is offered by DOE to advance its four broad mission areas:

  16. National Library of Energy (Beta): the Department of Energy's National

    Office of Scientific and Technical Information (OSTI)

    Resource for Energy Literacy, Innovation and Security - FAQ Frequently Asked Questions What is the National Library of EnergyBeta (NLEBeta)? Why was the NLEBeta created? What does the NLEBeta search? What DOE program offices and national laboratories are included in the NLEBeta? Does the NLEBeta include any classified information? Does the NLEBeta host, edit, or revise any of the content on the NLEBeta? How is the NLEBeta search related to the DOE Energy.gov search? How often will the

  17. Wnt/{beta}-catenin signaling changes C2C12 myoblast proliferation and differentiation by inducing Id3 expression

    SciTech Connect (OSTI)

    Zhang, Long; Shi, Songting; Zhang, Juan; Zhou, Fangfang; Dijke, Peter ten

    2012-03-02

    Highlights: Black-Right-Pointing-Pointer Expression of Id3 but not Id1 is induced by Wnt3a stimulation in C2C12 cells. Black-Right-Pointing-Pointer Wnt3a induces Id3 expression via canonical Wnt/{beta}-catenin pathway. Black-Right-Pointing-Pointer Wnt3a-induced Id3 expression does not depend on BMP signaling activation. Black-Right-Pointing-Pointer Induction of Id3 expression is critical determinant in Wnt3a-induced cell proliferation and differentiation. -- Abstract: Canonical Wnt signaling plays important roles in regulating cell proliferation and differentiation. In this study, we report that inhibitor of differentiation (Id)3 is a Wnt-inducible gene in mouse C2C12 myoblasts. Wnt3a induced Id3 expression in a {beta}-catenin-dependent manner. Bone morphogenetic protein (BMP) also potently induced Id3 expression. However, Wnt-induced Id3 expression occurred independent of the BMP/Smad pathway. Functional studies showed that Id3 depletion in C2C12 cells impaired Wnt3a-induced cell proliferation and alkaline phosphatase activity, an early marker of osteoblast cells. Id3 depletion elevated myogenin induction during myogenic differentiation and partially impaired Wnt3a suppressed myogenin expression in C2C12 cells. These results suggest that Id3 is an important Wnt/{beta}-catenin induced gene in myoblast cell fate determination.

  18. Charge states of Ca atoms in {beta}-dicalcium silicate

    SciTech Connect (OSTI)

    Mori, Kazuhiro . E-mail: kmori@rri.kyoto-u.ac.jp; Kiyanagi, Ryoji; Yonemura, Masao; Iwase, Kenji; Sato, Takashi; Itoh, Keiji; Sugiyama, Masaaki; Kamiyama, Takashi; Fukunaga, Toshiharu

    2006-11-15

    In order to study the crystal structure of {beta}-bar Ca{sub 2}SiO{sub 4}, time-of-flight neutron powder diffraction experiments were carried out at temperatures between room temperature (RT) and 600 deg. C. Rietveld refinement at RT has shown that {beta}-bar Ca{sub 2}SiO{sub 4} is monoclinic based on P2{sub 1}/n symmetry and two different types of Ca sites, Ca(1) and Ca(2). All interatomic distances within 3A were calculated, with the valences of Ca(1) with seven Ca-O bonds and Ca(2) with eight were estimated to be 1.87+ and 2+ by the Zachariasen-Brown-Altermatt formula (bond valence sum). Applying charge neutrality the two charge states of Ca in {beta}-bar Ca{sub 2}SiO{sub 4} are [Ca(1)SiO{sub 4}]{sup 2-} and Ca(2){sup 2+}, respectively. Furthermore, the [Ca(1)SiO{sub 4}]{sup 2-} unit has the shortest Ca-O distance, and its length kept constant at 2.23A at all temperatures. In the short-range structure analysis at RT, the shortest Ca-O bond was also observed in a radial distribution function. These results imply that the [Ca(1)SiO{sub 4}]{sup 2-} unit has covalency on the shortest Ca-O in addition to Si-O.

  19. Tribimaximal neutrino mixing and neutrinoless double beta decay

    SciTech Connect (OSTI)

    Hirsch, M.; Morisi, S.; Valle, J. W. F. [AHEP Group, Institut de Fisica Corpuscular-- C.S.I.C./Universitat de Valencia, Edificio Institutos de Paterna, Apt 22085, E-46071 Valencia (Spain)

    2008-11-01

    We present a tribimaximal lepton mixing scheme where the neutrinoless double beta decay rate has a lower bound which correlates with the ratio {alpha}{identical_to}{delta}m{sub sol}{sup 2}/{delta}m{sub atm}{sup 2} well determined by current data, as well as with the unknown Majorana CP phase {phi}{sub 12} characterizing the solar neutrino subsystem. For the special value {phi}{sub 12}=({pi}/2) (opposite CP-sign neutrinos) the {beta}{beta}{sub 0{nu}} rate vanishes at tree level when {delta}m{sub sol}{sup 2}/{delta}m{sub atm}{sup 2}=3/80, only allowed at 3{sigma}. For all other cases the rate is nonzero, and lies within current and projected experimental sensitivities close to {phi}{sub 12}=0. We suggest two model realizations of this scheme in terms of A{sub 4}xZ{sub 2} and A{sub 4}xZ{sub 4} flavor symmetries.

  20. Report of the Review of the Hanford Solid Waste Environmental Impact

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Statement regarding Data Quality Control and Management Issues | Department of Energy of the Review of the Hanford Solid Waste Environmental Impact Statement regarding Data Quality Control and Management Issues Report of the Review of the Hanford Solid Waste Environmental Impact Statement regarding Data Quality Control and Management Issues As part of the litigation involving receipt of offsite waste and the HSW EIS, the Court allowed the State of Washington a limited amount of discovery

  1. Decision document for the sanitary sewer system interim response action at Rocky Mountain Arsenal. Final report

    SciTech Connect (OSTI)

    Not Available

    1989-03-01

    The Interim Response Action (IRA) for the Sanitary Sewer System at the Rocky Mountain Arsenal (RMA) is being conducted as part of the IRA process for RMA in accordance with the June 5, 1987 report to the court in United States v. Shell Oil Co. and the proposed modified Consent Decree. This IRA project will consist of 'remediation of certain priority portions of the sanitary sewer to minimize the potential pathway of contaminant flow' (para 9.1(j), Consent Decree, 1988).

  2. Physics Division activities report, 1986--1987

    SciTech Connect (OSTI)

    Not Available

    1987-01-01

    This report summarizes the research activities of the Physics Division for the years 1986 and 1987. Areas of research discussed in this paper are: research on e/sup +/e/sup /minus// interactions; research on p/bar p/ interactions; experiment at TRIUMF; double beta decay; high energy astrophysics; interdisciplinary research; and advanced technology development and the SSC.

  3. Structural basis for specificity of TGF[beta] family receptor small molecule inhibitors

    SciTech Connect (OSTI)

    Ogunjimi, Abiodun A.; Zeqiraj, Elton; Ceccarelli, Derek F.; Sicheri, Frank; Wrana, Jeffrey L.; David, Laurent

    2012-07-24

    Transforming growth factor-{beta} (TGF{beta}) receptor kinase inhibitors have a great therapeutic potential. SB431542 is one of the mainly used kinase inhibitors of the TGF{beta}/Activin pathway receptors, but needs improvement of its EC{sub 50} (EC{sub 50} = 1 {mu}M) to be translated to clinical use. A key feature of SB431542 is that it specifically targets receptors from the TGF{beta}/Activin pathway but not the closely related receptors from the bone morphogenic proteins (BMP) pathway. To understand the mechanisms of this selectivity, we solved the crystal structure of the TGF{beta} type I receptor (T{beta}RI) kinase domain in complex with SB431542. We mutated T{beta}RI residues coordinating SB431542 to their counterparts in activin-receptor like kinase 2 (ALK2), a BMP receptor kinase, and tested the kinase activity of mutated T{beta}RI. We discovered that a Ser280Thr mutation yielded a T{beta}RI variant that was resistant to SB431542 inhibition. Furthermore, the corresponding Thr283Ser mutation in ALK2 yielded a BMP receptor sensitive to SB431542. This demonstrated that Ser280 is the key determinant of selectivity for SB431542. This work provides a framework for optimising the SB431542 scaffold to more potent and selective inhibitors of the TGF{beta}/Activin pathway.

  4. Neutrinoless double {beta}-decay nuclear matrix elements within the SRQRPA with self-consistent short range correlations

    SciTech Connect (OSTI)

    Benes, Petr [IEAP, Czech Technical University (Czech Republic); Simkovic, Fedor [Department of Nuclear Physics and Biophysics, Comenius University, Mlynska dolina, SK-84248 Bratislava (Slovakia); Bogolyubov Laboratory of Theoretical Physics, JINR, Dubna (Russian Federation)

    2009-11-09

    The nuclear matrix elements M{sup 0v} of the neutrinoless double beta decay (0v{beta}{beta}-decay) are systematically evaluated using the self-consistent renormalized quasiparticle random phase approximation (SRQRPA). The residual interaction and the two-nucleon short-range correlations are derived from the charge-dependent Bonn (CD-Bonn) potential. The importance of further progress in the calculation of the 0v{beta}{beta}-decay nuclear matrix elements is stressed.

  5. Key residues for the oligomerization of A{beta}42 protein in Alzheimer's disease

    SciTech Connect (OSTI)

    Ngo, Sam; Guo, Zhefeng

    2011-10-28

    Highlights: Black-Right-Pointing-Pointer A{beta} oligomers are neurotoxins and likely the causing agents for Alzheimer's disease. Black-Right-Pointing-Pointer A{beta}42 fusion protein form globular oligomers. Black-Right-Pointing-Pointer A{beta}42 fusion protein oligomers contain SDS-resistant tetramers and hexamers. Black-Right-Pointing-Pointer Cysteine substitutions at residues 31, 32, 34, 39-41 disrupt A{beta}42 oligomerization. -- Abstract: Deposition of amyloid fibrils consisting of amyloid {beta} (A{beta}) protein as senile plaques in the brain is a pathological hallmark of Alzheimer's disease. However, a growing body of evidence shows that soluble A{beta} oligomers correlate better with dementia than fibrils, suggesting that A{beta} oligomers may be the primary toxic species. The structure and oligomerization mechanism of these A{beta} oligomers are crucial for developing effective therapeutics. Here we investigated the oligomerization of A{beta}42 in the context of a fusion protein containing GroES and ubiquitin fused to the N-terminus of A{beta} sequence. The presence of fusion protein partners, in combination with a denaturing buffer containing 8 M urea at pH 10, is unfavorable for A{beta}42 aggregation, thus allowing only the most stable structures to be observed. Transmission electron microscopy showed that A{beta}42 fusion protein formed globular oligomers, which bound weakly to thioflavin T and Congo red. SDS-PAGE shows that A{beta}42 fusion protein formed SDS-resistant hexamers and tetramers. In contrast, A{beta}40 fusion protein remained as monomers on SDS gel, suggesting that the oligomerization of A{beta}42 fusion protein is not due to the fusion protein partners. Cysteine scanning mutagenesis at 22 residue positions further revealed that single cysteine substitutions of the C-terminal hydrophobic residues (I31, I32, L34, V39, V40, and I41) led to disruption of hexamer and tetramer formation, suggesting that hydrophobic interactions between these

  6. Beta-decay measurements of neutron-deficient cesium isotopes

    SciTech Connect (OSTI)

    Parry, R.F.

    1983-03-01

    Beta decay endpoint energy measurements of the neutron deficient cesium isotopes were done using an energy spectrum shape fitting technique. This was a departure from the typical method of endpoint energy analysis, the Fermi-Kurie plot. A discussion of the shape fitting procedure and its improved features are discussed. These beta endpoint measurements have led to total decay energies (Q/sub EC/) of the neutron deficient /sup 119/ /sup 123/Cs isotopes. The total decay energies of /sup 122m/Cs (Q/sub EC/ = 6.95 +- 0.25 MeV) and /sup 119/Cs (Q/sub EC/ = 6.26 +- 0.29 MeV) were new measurements. The total decay energies of /sup 123/Cs (Q/sub EC/ = 4.05 +- 0.18 MeV), /sup 122g/Cs (Q/sub EC/ = 7.05 +- 0.18 MeV), /sup 121/Cs (Q/sub EC/ = 5.21 +- 0.22 MeV), and /sup 120/Cs (Q/sub EC/ = 7.38 +- 0.23 MeV) were measurements with significantly improved uncertainties as compared to the literature. Further, a combination of the energy levels derived from previous literature gamma-gamma coincident measurements and the experimental beta-coincident gamma decay energies has supported an improved level scheme for /sup 121/Xe and the proposal of three new energy levels in /sup 119/Xe. Comparison of the experimental cesium mass excesses (determined with our Q/sub EC/ values and known xenon mass excesses) with both the literature and theoretical predicted values showed general agreement except for /sup 120/Cs. Possible explanations for this deviation are discussed.

  7. Beam position monitor sensitivity for low-{beta} beams

    SciTech Connect (OSTI)

    Shafer, R.E.

    1993-11-01

    At low velocities, the EM field of a particle in a conducting beam tube is no longer a TEM wave, but has a finite longitudinal extent. The net effect of this is to reduce the coupling of the high-frequency Fourier components of the beam current to BPM (beam position monitor) electrodes, which modifies the BPM sensitivity to beam displacement. This effect is especially pronounced for high-frequency, large-aperture pickups used for low-{beta} beams. Non-interceptive beam position monitors used in conjunction with high frequency RFQ (radio-frequency-quadrupole) and DTL (drift-tube-linac) accelerators fall into this category. When testing a BPM with a thin wire excited with either pulses or high-frequency sinusoidal currents, the EM wave represents the principal (TEM) mode in a coaxial transmission line, which is equivalent to a highly relativistic ({beta} = 1) beam. Thus wire measurements are not suitable for simulating slow particle beams in high bandwidth diagnostic devices that couple to the image currents in the beam tube wall. Attempts to load the tin wire either capacitively or inductively to slow the EM wave down have met with limited success. In general, the equations used to represent the 2-D response of cylindrical-geometry BPMs to charged-particle beams make several assumptions: (1) the BPM electrodes are flush with and grounded to the surface of the conducting beam tube; (2) the beam is a line source (pencil beam); (3) the longitudinal extent of the EM field of a beam particle at the beam tube wall is zero, corresponding to a highly relativistic beam. The purpose of this paper is to make some quantitative estimates of the corrections to the conventional approximations when a BPM is used to measure the position of low velocity (low-{beta}) beams.

  8. Data Testing for ENDF/B-VII.1beta2

    SciTech Connect (OSTI)

    MacFarlane, Robert

    2011-01-01

    Calculations have been performed for 390 critical assemblies from the International Handbook of Evaluated Criticality Safety Benchmark Experiments using the beta2 release of ENDF/B-VII.1. The results are compared to previous results for ENDF/B-VII. Cases that changed between the two versions are highlighted, and the results are discussed. The Cross Section Evaluation Working Group (CSEWG) is working on a new release of the ENDF/B-VII library of evaluated nuclear data, and the 'beta2' set of files was recently made available by the National Nuclear Data Center (NNDC). A set of about 850 input files for the MCNP Monte Carlo code to run critical assemblies from the International Handbook of Evaluated Criticality Safety Benchmark Experiments was available from our previous data testing work for ENDF/B-VII.0. We have now run 390 of those cases using data based on the beta2 files, and those results will be presented below. The ENDF files were downloaded from the NNDC to a Mac workstation. They were then processed using NJOY10 into ACE format files for use in the MCNP Monte Carlo code. The processing was limited to materials needed for the data testing work at this point. The existing MCNP input decks were used. No checking was done to see if any of the benchmarks had been updated since the ENDF/B-VII testing was finished. Most runs used 50 million histories in order to get Monte Carlo statistical uncertainties down the 0.01% range.

  9. Trash, ash and the phoenix : a fifth anniversary review of the Supreme Court's City of Chicago waste-to-energy combustion ash decision.

    SciTech Connect (OSTI)

    Puder, M. G.; Environmental Assessment

    1999-01-01

    In 1994, the U.S. Supreme Court held that ash generated by waste-to-energy (WTE) facilities was not exempt from Subtitle C hazardous waste management regulations under the Resource Conservation and Recovery Act (RCRA). As a result of City of Chicago v. Environmental Defense Fund, Inc., WTE installations are required to test their combustion ash and determine whether it is hazardous. The WTE industry and the municipalities utilizing WTE technologies initially feared that if significant amounts of their ash tested hazardous, the costs and liabilities associated with RCRA Subtitle C hazardous waste management requirements would pose a serious threat to the continued viability of the WTE concept. In this article, the author presents a review of the WTE industry in the five years following the decision, and finds that the specter of the decline of WTE has not materialized.

  10. Unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not promote human monocyte differentiation toward alternative macrophages

    SciTech Connect (OSTI)

    Bouhlel, Mohamed Amine; Inserm U545, F-59000 Lille; UDSL, F-59000 Lille; Institut Pasteur de Lille, F-59019 Lille ; Brozek, John; Derudas, Bruno; Inserm U545, F-59000 Lille; UDSL, F-59000 Lille; Institut Pasteur de Lille, F-59019 Lille ; Zawadzki, Christophe; Jude, Brigitte; Staels, Bart; Inserm U545, F-59000 Lille; UDSL, F-59000 Lille; Institut Pasteur de Lille, F-59019 Lille ; Chinetti-Gbaguidi, Giulia; Inserm U545, F-59000 Lille; UDSL, F-59000 Lille; Institut Pasteur de Lille, F-59019 Lille

    2009-08-28

    Macrophages adapt their response to micro-environmental signals. While Th1 cytokines promote pro-inflammatory M1 macrophages, Th2 cytokines promote an 'alternative' anti-inflammatory M2 macrophage phenotype. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors expressed in macrophages where they control the inflammatory response. It has been shown that PPAR{gamma} promotes the differentiation of monocytes into anti-inflammatory M2 macrophages in humans and mice, while a role for PPAR{beta}/{delta} in this process has been reported only in mice and no data are available for PPAR{alpha}. Here, we show that in contrast to PPAR{gamma}, expression of PPAR{alpha} and PPAR{beta}/{delta} overall does not correlate with the expression of M2 markers in human atherosclerotic lesions, whereas a positive correlation with genes of lipid metabolism exists. Moreover, unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not influence human monocyte differentiation into M2 macrophages in vitro. Thus, PPAR{alpha} and PPAR{beta}/{delta} do not appear to modulate the alternative differentiation of human macrophages.